Inventory of File sref.t03z.pgrb132.spread_3hrly.grib2

Science.gov Websites

ground UGRD analysis U-Component of Wind [m/s] std dev 002 10 m above ground VGRD analysis V-Component of Wind [m/s] std dev 003 1000 mb UGRD analysis U-Component of Wind [m/s] std dev 004 850 mb UGRD analysis U-Component of Wind [m/s] std dev 005 700 mb UGRD analysis U-Component of Wind [m/s] std dev 006 600

The Army Communications Objectives Measurement System (ACOMS): Codebook for the Message Content Analysis Data File

DTIC Science & Technology

1988-07-01

0.1 400 SELF-DEVELOPMENT 176 4.8 420 DEV SELF-CONFID 15 0.4 430 DEV MATURE PERSN a 0.2 440 DEV POTENTIAL 367 10.0 450 ADVTG OVER COLLG 23 0.6 471 DEV...OVER COLLG 22 0.6 471 DEV DISCIPLINE it 0.3 481 DEVELOP PRIDE 7 0.2 500 MONEY/BENEFITS 116 3.2 600 EDUC/BENEFITS 279 7.6 700 TRAVEL 43 1.2 821 ADVENTURE...OVER COLLG 9 0.2 460 WRK HITRAIN PEOP 1 0.0 471 DEV DISCIPLINE 7 0.2 491 DEVELOP PRIDE 4 0.1 500 MONEY/BENEFITS 40 1.1 600 EDUC/BENEFITS 90 2.5 700

78 FR 28600 - National Institute of General Medical Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-15

.... Trempe, Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute of General..., 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Lee Warren Slice, Ph.D., Scientific Review..., Cell Biology and Biophysics Research; 93.859, Pharmacology, Physiology, and Biological Chemistry...

78 FR 35942 - National Institute of General Medical Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

...). Contact Person: Nina Sidorova, Ph.D., Scientific Review Officer, Office of Scientific Review, National.... Johnson, Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute of General..., Physiology, and Biological Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88...

78 FR 13689 - National Institute of General Medical Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... Person: Brian R. Pike, Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute... R. Pike, Ph.D., Scientific Review Officer, National Institute of General Medical Sciences, National..., Cell Biology and Biophysics Research; 93.859, Pharmacology, Physiology, and Biological Chemistry...

78 FR 37557 - National Institute of General Medical Sciences; Notice of Closed Meetings

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...: Margaret J. Weidman, Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute of..., Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute of General Medical..., and Biological Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88...

78 FR 63231 - National Institute of General Medical Sciences; Notice of Closed Meetings

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2013-10-23

... Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Nina Sidorova, Ph.D., Scientific Review Officer..., Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute of General Medical... Biological Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to...

77 FR 62245 - National Institute of General Medical Sciences Notice of Closed Meetings

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... Slice, Ph.D., Scientific Review Officer, David Geffen School of Medicine, University of California, Los... North, 6130 Executive Boulevard, Room H, Rockville, MD 20892. Contact Person: Arthur L. Zachary, Ph.D..., Cell Biology and Biophysics Research; 93.859, Pharmacology, Physiology, and Biological Chemistry...

Whole genome sequencing of the Braconid parasitoid wasp Fopius arisanus, an important biocontrol agent of pest Tepritid fruit flies

USDA-ARS?s Scientific Manuscript database

The braconid wasp Fopius arisanus (Sonan) is an important biological control agent of tropical and subtropical pest fruit flies including two important global pests, the Mediterranean fruit fly (Ceratitis capitata), and the oriental fruit fly (Bactrocera dorsalis}). The goal of this study was to dev...

Driver's Enhanced Vision System (DEVS)

DOT National Transportation Integrated Search

1996-12-23

This advisory circular (AC) contains performance standards, specifications, and : recommendations for Drivers Enhanced Vision sSystem (DEVS). The FAA recommends : the use of the guidance in this publication for the design and installation of : DEVS e...

Hala Azzam, PhD, MPH | Division of Cancer Prevention

Cancer.gov

Dr. Hala Azzam is a Cancer Epidemiologist in the Cancer Prevention Fellowship Program (CPFP) in the Division of Cancer Prevention within the National Cancer Institute. She received her Bachelor's degree in molecular biology from Kings College London University, her PhD in anatomy and cell biology from Georgetown University Lombardi Cancer Center, and her MPH in epidemiology

Software Sustainment -- Now and Future

DTIC Science & Technology

2014-01-01

today the commercial environment is using something referred to as DevOps . What is DevOps ? What it is. A way of working that encourages the Develop...section. However, there are some major differences. DevOps seems to be the Agile community’s term for doing sustainment and opera- tions in parallel...methods in sustainment within the federal government. This research is how I came upon the term DevOps . In addition, Gene Kim provided a keynote

The NeuroDevNet Autism Spectrum Disorders Demonstration Project.

PubMed

Zwaigenbaum, Lonnie; Scherer, Stephen; Szatmari, Peter; Fombonne, Eric; Bryson, Susan E; Hyde, Krista; Anagnostou, Evdokia; Anognostou, Evdokia; Brian, Jessica; Evans, Alan; Hall, Geoff; Nicholas, David; Roberts, Wendy; Smith, Isabel; Vaillancourt, Tracy; Volden, Joanne

2011-03-01

The NeuroDevNet Autism Spectrum Disorder Demonstration Project interfaces at many levels with the network's research themes and priorities. Our interdisciplinary team aims to improve understanding of genetic factors underlying vulnerability to autism spectrum disorders (ASDs) to develop better diagnostic strategies and, ultimately, to pinpoint molecular pathways relevant to developing biologically based treatments. Linking our existing longitudinal ASD cohorts with both genetics and neuroimaging studies will provide, for the first time, integrated data on how the genetic variation influences brain and behavioral development in ASD. Importantly, as our science progresses and we translate this information to the health care system, we will also educate policy makers, media, and business, so an informed society is prepared to capitalize on new genomic advances and effectively integrate these into health services for the broader community. We believe that this research has the potential to transform assessment and care for individuals with ASD. Copyright © 2011 Elsevier Inc. All rights reserved.

Regulation of ATM-Dependent DNA Damage Responses in Breast Cancer by the RhoGEF Net1

DTIC Science & Technology

2014-04-01

1998) Science 279: 509-514. 12. Harper JW, et al., (2007) The DNA Damage Response: Ten years after. Mol. Cell 28; 739-745. 13. Hill R, et al., (2010...RhoGTPases: Biochemistry and Biology. Annu. Rev. Cell Dev. Biol. 21:247-269. 17. Khanna KK, et al., (2001) ATM, a central controller of cellular

From Domain Specific Languages to DEVS Components: Application to Cognitive M&S

DTIC Science & Technology

2011-04-01

AND SUBTITLE From Domain Specific Languages to DEVS Components: Application to Cognitive M&S 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ...that is devoid of any DEVS and programming language constructs (Figure 4). The key idea being domain specialists need not delve in the DEVS world to...DSL. DSLs can be created using many available tools and technologies such as: Generic Modeling Environment (GME) [23], Xtext, Ruby, Scala and many

Inventory of File sref.t03z.pgrb197.spread_ds_3hrly.grib2

Science.gov Websites

3 hour fcst U-Component of Wind [m/s] std dev 002 10 m above ground VGRD 3 hour fcst V-Component of Wind [m/s] std dev 003 2 m above ground TMP 3 hour fcst Temperature [K] std dev 004 2 m above ground SPFH 3 hour fcst Specific Humidity [kg/kg] std dev 005 10 m above ground WIND 3 hour fcst Wind Speed [m

In Memoriam: Amar J.S. Klar, Ph.D. | Center for Cancer Research

Cancer.gov

In Memoriam: Amar J.S. Klar, Ph.D. The Center for Cancer Research mourns the recent death of colleague and friend Amar J.S. Klar, Ph.D.  Dr. Klar was a much-liked and respected member of the NCI community as part of the Gene Regulation and Chromosome Biology Laboratory since 1988.

Characterization and genome sequence of Dev2, a new T7-like bacteriophage infecting Cronobacter turicensis.

PubMed

Kajsík, Michal; Oslanecová, Lucia; Szemes, Tomáš; Hýblová, Michalea; Bilková, Andrea; Drahovská, Hana; Turňa, Ján

2014-11-01

Cronobacter spp. are opportunistic pathogenic bacteria that are responsible for severe infections in neonates. Powdered infant formula was confirmed to be the source in some cases. Bacteriophages offer a safe means for eliminating this pathogen. In the present study, we investigated the growth parameters and genome organization of a new bacteriophage, Dev2, isolated from sewage. The Dev2 phage contains DNA with a length of 39 kb and belongs to the T7 branch of the subfamily Autographivirinae, with the highest degree of identity to the phage K1F. The host specificity of Dev2 is limited to C. turicensis strains of the CT O:1 serotype. With a lower efficiency, this phage also infects some Salmonella and E. coli strains. The Dev2 phage can inactivate sensitive Cronobacter strains in reconstituted milk formula. The results obtained in this study are an important prerequisite for application of Dev2 in food control.

Meet EPA Scientist Tim Shafer, Ph.D.

EPA Pesticide Factsheets

Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

Inventory of File sref.t03z.pgrb212.spread_1hrly.grib2

Science.gov Websites

UGRD 1 hour fcst U-Component of Wind [m/s] std dev 002 10 m above ground VGRD 1 hour fcst V-Component of Wind [m/s] std dev 003 1000 mb UGRD 1 hour fcst U-Component of Wind [m/s] std dev 004 850 mb UGRD 1 hour fcst U-Component of Wind [m/s] std dev 005 700 mb UGRD 1 hour fcst U-Component of Wind [m/s

Expression and distribution of the duck enteritis virus UL51 protein in experimentally infected ducks.

PubMed

Shen, Chanjuan; Cheng, Anchun; Wang, Mingshu; Xu, Chao; Jia, Renyong; Chen, Xiaoyue; Zhu, Dekang; Luo, Qihui; Cui, Hengmin; Zhou, Yi; Wang, Yin; Xu, Zhiwen; Chen, Zhengli; Wang, Xiaoyu

2010-06-01

To determine the expression and distribution of tegument proteins encoded by duck enteritis virus (DEV) UL51 gene in tissues of experimentally infected ducks, for the first time, an immunoperoxidase staining method to detect UL51 protein (UL51p) in paraffin-embedded tissues is reported. A rabbit anti-UL51 polyclonal serum, raised against a recombinant 6-His-UL51 fusion protein expressed in Escherichia coli, was prepared, purified, and used as primary antibodies. Fifty-eight 30-day-old DEV-free ducks were intramuscularly inoculated with the pathogenic DEV CHv strain as infection group, and two ducks were selected as preinfection group. The tissues were collected at sequential time points between 2 and 480 hr postinoculation (PI) and prepared for immunoperoxidase staining. DEV UL51p was first found in the spleen and liver at 8 hr PI; in the bursa of Fabricius and thymus at 12 hr PI; in the Harders glands, esophagus, small intestine (including the duodenum, jejunum, and ileum), and large intestine (including the caecum and rectum) at 24 hr PI; in the glandularis ventriculus at 48 hr PI; and in the pancreas, cerebrum, kidney, lung, and myocardium at 72 hr PI. Throughout the infection process, the UL51p was not seen in the muscle. Furthermore, the intensity of positive staining of DEV UL51p antigen in various tissues increased sharply from 8 to 96 hr PI, peaked during 120-144 hr PI, and then decreased steadily from 216 to 480 hr PI, suggesting that the expressional levels of DEV UL51p in systemic organs have a close correlation with the progression of duck virus enteritis (DVE) disease. A number of DEV UL51p was distributed in the bursa of Fabricius, thymus, spleen, liver, esophagus, small intestine, and large intestine of DEV-infected ducks, whereas less DEV UL51p was distributed in the Harders glands, glandularis ventriculus, cerebrum, kidney, lung, pancreas, and myocardium of DEV-infected ducks. Moreover, DEV UL51p can be expressed in the cytoplasm of various types of cells, especially most abundantly in the cytoplasm of lymphocytes, reticulum cells, macrophages, epithelial cells, and hepatocytes. The present study may be useful not only for describing the characteristics of UL51p expression and distribution in vivo but also for a greater understanding of the pathogenesis of this DVE.

Association between Antioxidant Enzyme Activities and Enterovirus-Infected Type 1 Diabetic Children.

PubMed

Abdel-Moneim, Adel; El-Senousy, Waled M; Abdel-Latif, Mahmoud; Khalil, Rehab G

2018-01-01

To examine the effect of infection with Enterovirus (EV) in children with type 1 diabetes (T1D) on the activities of serum antioxidant enzymes in diabetic and nondiabetic controls. Three hundred and eighty-two diabetic and 100 nondiabetic children were tested for EV RNA using reverse transcriptase (RT)-PCR. The activities of serum superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were also estimated in diabetic patients infected with EV (T1D-EV+), those not infected with EV (T1D-EV-), and in nondiabetic controls. The frequency of EV was higher in diabetic children (100/382; 26.2%) than in healthy controls (0/100). Levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP) were significantly higher but C-peptide was significantly lower in diabetic children than in controls. CRP levels were higher in the T1D-EV+ group than in the T1D-EV- group, and higher in all diabetic children than in nondiabetic controls. The activities of the antioxidant enzymes GPx, SOD, and CAT decreased significantly in diabetic children compared to in controls. Moreover, the activities of the enzymes tested were significantly reduced in the T1D-EV+ group compared to in the T1D-EV- group. Our data indicate that EV infection correlated with a decrease in the activity of antioxidant enzymes in the T1D-EV+ group compared to in the T1D-EV- group; this may contribute to β cell damage and increased inflammation. © 2018 The Author(s) Published by S. Karger AG, Basel.

Implementation of an Education-Focused PhD Program in Anatomy and Cell Biology at Indiana University: Lessons Learned and Future Challenges

ERIC Educational Resources Information Center

Brokaw, James J.; O'Loughlin, Valerie D.

2015-01-01

In 2008, the Indiana University School of Medicine, in collaboration with the School of Education, admitted its first student to a newly approved PhD program in Anatomy and Cell Biology focusing on educational research rather than biomedical research. The goal of the program is twofold: (1) to provide students with extensive training in all of the…

PDB-Dev: a Prototype System for Depositing Integrative/Hybrid Structural Models.

PubMed

Burley, Stephen K; Kurisu, Genji; Markley, John L; Nakamura, Haruki; Velankar, Sameer; Berman, Helen M; Sali, Andrej; Schwede, Torsten; Trewhella, Jill

2017-09-05

Burley et al. (leadership of the Worldwide PDB [wwPDB] Partnership [wwpdb.org] and the wwPDB Integrative/Hybrid Methods Task Force) announce public release of a prototype system for depositing integrative/hybrid structural models, PDB-Development (PDB-Dev; https://pdb-dev.wwpdb.org). Copyright © 2017. Published by Elsevier Ltd.

IT Software Development and IT Operations Strategic Alignment: An Agile DevOps Model

ERIC Educational Resources Information Center

Hart, Michael

2017-01-01

Information Technology (IT) departments that include development and operations are essential to develop software that meet customer needs. DevOps is a term originally constructed from software development and IT operations. DevOps includes the collaboration of all stakeholders such as software engineers and systems administrators involved in the…

Oral biology in middle age: a history of the University at Buffalo Oral Biology PhD Program.

PubMed

Scannapieco, F A

2014-05-01

In 1960, the first Department of Oral Biology in the United States dedicated to the conduct of research, graduate biomedical research education, and the provision of basic oral science education for the DDS curriculum was established at the University at Buffalo. In 1963, the Department organized the first PhD Program in Oral Biology in the United States. This PhD program has produced a large cadre of oral health researchers, many of whom have gone on to make major contributions to dental research and education. This article provides a brief history of the program, the context within which the program was organized and developed, and a description of some of the many faculty, students, and fellows associated with the program. Additionally, to celebrate the 50th anniversary of this program, a symposium, entitled "The Oral Microbiome, Immunity and Chronic Disease", was held on June 12-14, 2013, in Buffalo, New York. The proceedings are published online in Advances in Dental Research (2014, Vol. 26).

High Surplus Energy Status Blocks Protective Breast Cancer Gene | Center for Cancer Research

Cancer.gov

High caloric intake, weight gain, and obesity are associated with increased risk of postmenopausal breast cancer, but little is known about the molecular processes through which these metabolic factors contribute to cancer. Li-Jun Di, Ph.D., and Alfonso Fernandez, Ph.D., postdoctoral fellows working with Kevin Gardner, M.D., Ph.D., in CCR's Laboratory of Receptor Biology and

DEVS representation of dynamical systems - Event-based intelligent control. [Discrete Event System Specification

NASA Technical Reports Server (NTRS)

Zeigler, Bernard P.

1989-01-01

It is shown how systems can be advantageously represented as discrete-event models by using DEVS (discrete-event system specification), a set-theoretic formalism. Such DEVS models provide a basis for the design of event-based logic control. In this control paradigm, the controller expects to receive confirming sensor responses to its control commands within definite time windows determined by its DEVS model of the system under control. The event-based contral paradigm is applied in advanced robotic and intelligent automation, showing how classical process control can be readily interfaced with rule-based symbolic reasoning systems.

High Surplus Energy Status Blocks Protective Breast Cancer Gene | Center for Cancer Research

Cancer.gov

High caloric intake, weight gain, and obesity are associated with increased risk of postmenopausal breast cancer, but little is known about the molecular processes through which these metabolic factors contribute to cancer. Li-Jun Di, Ph.D., and Alfonso Fernandez, Ph.D., postdoctoral fellows working with Kevin Gardner, M.D., Ph.D., in CCR's Laboratory of Receptor Biology and Gene Expression, were part of a research team that recently discovered a link between cellular metabolism and BRCA1, a protein involved in DNA repair as well as the regulation of cell cycle and the expression of many genes. Their findings were published in a recent issue of Nature Structural and Molecular Biology.

An interdepartmental Ph.D. program in computational biology and bioinformatics: the Yale perspective.

PubMed

Gerstein, Mark; Greenbaum, Dov; Cheung, Kei; Miller, Perry L

2007-02-01

Computational biology and bioinformatics (CBB), the terms often used interchangeably, represent a rapidly evolving biological discipline. With the clear potential for discovery and innovation, and the need to deal with the deluge of biological data, many academic institutions are committing significant resources to develop CBB research and training programs. Yale formally established an interdepartmental Ph.D. program in CBB in May 2003. This paper describes Yale's program, discussing the scope of the field, the program's goals and curriculum, as well as a number of issues that arose in implementing the program. (Further updated information is available from the program's website, www.cbb.yale.edu.)

A "Research" into International Student-Related Research: (Re)visualising Our Stand?

ERIC Educational Resources Information Center

Abdullah, Doria; Abd Aziz, Mohd Ismail; Mohd Ibrahim, Abdul Latiff

2014-01-01

This paper uses Tight ("High Educ Res Dev" 23(4):395-411, 2004; "High Educ Res Dev" 31(5):723-740, 2012; "High Educ Res Dev" 32(1):136-151, 2013)'s journal analysis and review framework to review a sample of 497 journal articles on researches concerning international students over the past 30 years. It was found…

Dynamic Self-Organization and Early Lexical Development in Children

ERIC Educational Resources Information Center

Li, Ping; Zhao, Xiaowei; Whinney, Brian Mac

2007-01-01

In this study we present a self-organizing connectionist model of early lexical development. We call this model DevLex-II, based on the earlier DevLex model. DevLex-II can simulate a variety of empirical patterns in children's acquisition of words. These include a clear vocabulary spurt, effects of word frequency and length on age of acquisition,…

Bioinformatics analysis and characteristics of VP23 encoded by the newly identified UL18 gene of duck enteritis virus

NASA Astrophysics Data System (ADS)

Chen, Xiwen; Cheng, Anchun; Wang, Mingshu; Xiang, Jun

2011-10-01

In this study, the predicted information about structures and functions of VP23 encoded by the newly identified DEV UL18 gene through bioinformatics softwares and tools. The DEV UL18 was predicted to encode a polypeptide with 322 amino acids, termed VP23, with a putative molecular mass of 35.250 kDa and a predicted isoelectric point (PI) of 8.37, no signal peptide and transmembrane domain in the polypeptide. The prediction of subcellular localization showed that the DEV-VP23 located at endoplasmic reticulum with 33.3%, mitochondrial with 22.2%, extracellular, including cell wall with 11.1%, vesicles of secretory system with 11.1%, Golgi with 11.1%, and plasma membrane with 11.1%. The acid sequence of analysis showed that the potential antigenic epitopes are situated in 45-47, 53-60, 102-105, 173-180, 185-189, 260-265, 267-271, and 292-299 amino acids. All the consequences inevitably provide some insights for further research about the DEV-VP23 and also provide a fundament for further study on the the new type clinical diagnosis of DEV and can be used for the development of new DEV vaccine.

Construction of a recombinant duck enteritis virus vaccine expressing hemagglutinin of H9N2 avian influenza virus and evaluation of its efficacy in ducks.

PubMed

Sun, Ying; Yang, Chenghuai; Li, Junping; Li, Ling; Cao, Minghui; Li, Qihong; Li, Huijiao

2017-01-01

H9 subtype avian influenza viruses (AIVs) remain a significant burden in the poultry industry and are considered to be one of the most likely causes of any new influenza pandemic in humans. As ducks play an important role in the maintenance of H9 viruses in nature, successful control of the spread of H9 AIVs in ducks will have significant beneficial effects on public health. Duck enteritis virus (DEV) may be a promising candidate viral vector for aquatic poultry vaccination. In this study, we constructed a recombinant DEV, rDEV-∆UL2-HA, inserting the hemagglutinin (HA) gene from duck-origin H9N2 AIV into the UL2 gene by homologous recombination. One-step growth analyses showed that the HA gene insertion had no effect on viral replication and suggested that the UL2 gene was nonessential for virus growth in vitro. In vivo tests further showed that the insertion of the HA gene in place of the UL2 gene did not affect the immunogenicity of the virus. Moreover, a single dose of 10 3 TCID 50 of rDEV-∆UL2-HA induced solid protection against lethal DEV challenge and completely prevented H9N2 AIV viral shedding. To our knowledge, this is the first report of a DEV-vectored vaccine providing robust protection against both DEV and H9N2 AIV virus infections in ducks.

Investigator profile. An interview with Russell D. Fernald, Ph.D. Interview by Vicki Glaser.

PubMed

Fernald, Russell D

2006-01-01

Russell D. Fernald, Ph.D., is a Professor of Biological Sciences and the Benjamin Scott Crocker Professor in Human Biology at Stanford University (California). He received his Bachelor's degree from Swarthmore College (Swarthmore, PA) and his Ph.D. from the University of Pennsylvania (Philadelphia). Dr. Fernald completed a postdoctoral fellowship with Dr. O. Creutzfeldt at the Max-Planck-Institute for Psychiatry, in Munich, Germany, and a postdoctoral fellowship with Dr. Konrad Lorenz at the Max-Planck-Institute for Behavioral Physiology. In 2004 he shared the Rank Prize for discoveries about lens function. Dr. Fernald's lab uses an African cichlid fish species to study how social experience influences the brain and how retinal progenitor cell division and differentiation are controlled.

Bryon S. Donohoe, Ph.D | NREL

Science.gov Websites

structural biology and plant/algal cell biology to address questions about the cellular mechanisms involved Biology, University of Colorado at Boulder M.A., Biology, University of Colorado at Denver B.S

Standards for the Ph.D. Degree in the Molecular Biosciences.

ERIC Educational Resources Information Center

Vella, F.; de Meis, Leopoldo; Mehler, Alan H.; Rombauts, Wilfried; White, Harold B., III; Wood, E. J.

2000-01-01

Argues that the barriers between the traditional biosciences have disappeared while interdisciplinarity has become commonplace. Presents the suggested standards for Ph.D. degrees in biochemistry and molecular biology recommended by the Committee on Education of the International Union of Biochemistry. (Author/CCM)

76 FR 29770 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-23

... K. Saha, PhD, Scientific Review Officer, Program Coordination and Referral Branch, Division of..., PhD, Scientific Review Officer, Scientific Review and Logistic Branch, Division of Extramural....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93...

In-Situ Bioreduction and Removal of Ammonium Perchlorate

DTIC Science & Technology

2006-05-09

Ader, PhD. Max Coleman, PhD. Swades Chaudhuri, PhD. Susan O’Connor MSc, MSc Royce Bruce, MSc. Urania Michaelidou, MSc. Melissa Rice, MSc. Sarah...1993. SeqApp, 1.9a157 ed. Biocomputing Office, Biology Dept., Indiana University, Bloomington, IN. 44. Giordano , G., L. Saracino, and L. Grillet. 1985...Mutant of E. coli K-12. Biocimica et Biophysica Acta 839:181-190. 45. Guigliarelli, B., A. Magalon, M. Asso, P. Bertrand, C. Frixon, G. Giordano

Paul W. King, Ph.D., M.S. | NREL

Science.gov Websites

converting solar energy into biofuels. Specific areas of interest include using molecular, biochemical and Photochemical Conversion Photobiological Hydrogen Production Education Ph.D., Biochemistry and Molecular Biology , Mechanism, and Maturation," Biochimica et Biophysica Acta-Molecular Cell Research (2015) need_alt "

Patient Engagement Programs for Recognition and Initial Treatment of Depression in Primary Care: A Randomized Trial

PubMed Central

Kravitz, Richard L.; Franks, Peter; Feldman, Mitchell D.; Tancredi, Daniel J.; Slee, Christina A.; Epstein, Ronald M.; Duberstein, Paul R.; Bell, Robert A.; Jackson-Triche, Maga; Paterniti, Debora A.; Cipri, Camille; Iosif, Ana-Maria; Olson, Sarah; Kelly-Reif, Steven; Hudnut, Andrew; Dvorak, Simon; Turner, Charles; Jerant, Anthony

2015-01-01

Importance Interventions encouraging primary care patients’ engagement with their clinicians to address depression could improve outcomes but foster unnecessary treatment. Objective Determine whether a depression engagement video (DEV) or a tailored interactive multimedia computer program (IMCP) improves initial depression care without increasing unnecessary anti-depressant prescribing. Design Randomized controlled trial comparing three interventions (DEV, IMCP, and control) conducted in two patients groups (depressed, defined by a Patient Health Questionnaire [PHQ]-9 score ≥5, and non-depressed [PHQ-9<5]) conducted between June 2010 and March 2012. Setting Primary care offices at 7 sites in 2 cities. Participants Depressed (N=559) and non-depressed (N=308) adult patients of 135 primary care clinicians. Intervention(s) DEV targeted to gender and income; IMCP tailored to individual patient characteristics; a sleep hygiene video (control). Main Outcome Measure(s) Depressed patients: composite measure of antidepressant recommendation and/or mental health referral (primary outcome); 12-week mental health, measured by the PHQ-8 (secondary outcome). Non- depressed patients: clinician-reported prescribing and patient-reported antidepressant recommendation (primary outcomes, pre-specified 3.5% non-inferiority margins). Results Depressed patients: composite care outcome rates were 18%, 26%, and 16% respectively in the DEV, IMCP, and control groups (cluster-adjusted DEV-control difference = 1.1% [95% CI −6.7 to 8.9, P=.79]; IMCP-control = 9.9% [95% CI 1.6 to 18.2, P=.02]). Twelve-week PHQ-8 effects were not significant: DEV- control = −0.2 points (95% CI −1.2 to 0.8); IMCP – control = 0.9 (95% CI −0.1 to 1.9). Non-depressed patients: clinician-reported antidepressant prescribing in the DEV and IMCP groups was non-inferior to control (DEV-control = −2.2%, 90% CI −8.0 to 3.498, non-inferiority (NI) P=.0499; IMCP-control = −3.3%, 90% CI −9.1 to 2.4, NI P=.02); patient-reported antidepressant recommendation did not achieve non-inferiority: DEV-control = 0.9% (90% CI −4.9 to 6.7; NI P=.23); IMCP-control = 0.3% (90% CI −5.1 to 5.7; NI P=.16). Conclusions and Relevance A tailored IMCP increased antidepressant recommendation and/or mental health referral among depressed patients but had no effect on 12-week mental health. The possibility that the IMCP and DEV increased patient-reported antidepressant recommendations among non-depressed patients could not be excluded. Further research is needed on the benefits and harms of these interventions. PMID:24193079

Distributed Generation Renewable Energy Estimate of Costs | Energy Analysis

Science.gov Websites

viability. Table 1 Costs for Electric Generating Technologies Technology Type Mean installed cost ($/kW ) Installed cost Std. Dev. (+/- $/kW) Fixed O&M ($/kW-yr) Fixed O&M Std. Dev. (+/- $/kW-yr) Variable O cost ($/kWh) Fuel and/or water Std. Dev. ($/kWh) PV <10 kW $3,897 $889 $21 $20 n/a n/a 33 11 n/a n/a

Distributed Generation Renewable Energy Estimate of Costs | Energy Analysis

Science.gov Websites

viability. Table 1 Costs for Electric Generating Technologies Technology Type Mean installed cost ($/kW ) Installed cost Std. Dev. (+/- $/kW) Fixed O&M ($/kW-yr) Fixed O&M Std. Dev. (+/- $/kW-yr) Variable O cost ($/kWh) Fuel and/or water Std. Dev. ($/kWh) PV <10 kW $3,910 $921 $21 $20 n/a n/a 33 11 n/a n/a

Inventory of File spread.sref.cluster1.f03.grib2

Science.gov Websites

Records: 40 Number Level/Layer Parameter Forecast Valid Description 001 2 m above ground TMP 3 hour fcst Temperature [K] std dev 002 2 m above ground TMP 3 hour fcst Temperature [K] std dev 003 2 m above ground SPFH 3 hour fcst Specific Humidity [kg/kg] std dev 004 2 m above ground RH 3 hour fcst Relative Humidity

78 FR 31951 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Nuria E Assa-Munt, Ph.D., Scientific Review Officer...; Small Business: Education, Psychology, and Biology in Health Behavior. Date: June 24-25, 2013. Time: 8..., (Virtual Meeting). Contact Person: David R Filpula, Ph.D., Scientific Review Officer, Center for Scientific...

78 FR 51735 - Center For Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

...: Biological Chemistry and Macromolecular Biophysics. Date: August 26, 2013. Time: 11:00 a.m. to 12:00 p.m... Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Nitsa Rosenzweig, Ph.D... Conference Call). Contact Person: Aftab A Ansari, Ph.D., Scientific Review Officer, Center for Scientific...

76 FR 81953 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... Person: John Firrell, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes...: Biological Chemistry and Macromolecular Biophysics. Date: January 19-20, 2012. Time: 11 a.m. to 10 p.m... Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Donald L. Schneider, Ph.D., Scientific...

Structural Insight Into Histone Recognition by the ING PHD Fingers

PubMed Central

Champagne, Karen S.; Kutateladze, Tatiana G.

2009-01-01

The Inhibitor of Growth (ING) tumor suppressors are implicated in oncogenesis, control of DNA damage repair, cellular senescence and apoptosis. All members of the ING family contain unique amino-terminal regions and a carboxy-terminal plant homeodomain (PHD) finger. While the amino-terminal domains associate with a number of protein effectors including distinct components of histone deacetylase (HDAC) and histone acetyltransferase (HAT) complexes, the PHD finger binds strongly and specifically to histone H3 trimethylated at lysine 4 (H3K4me3). In this review we describe the molecular mechanism of H3K4me3 recognition by the ING1-5 PHD fingers, analyze the determinants of the histone specificity and compare the biological activities and structures within subsets of PHD fingers. The atomic-resolution structures of the ING PHD fingers in complex with a H3K4me3 peptide reveal that the histone tail is bound in a large and deep binding site encompassing nearly one-third of the protein surface. An extensive network of intermolecular hydrogen bonds, hydrophobic and cation-π contacts, and complementary surface interactions coordinate the first six residues of the H3K4me3 peptide. The trimethylated Lys4 occupies an elongated groove, formed by the highly conserved aromatic and hydrophobic residues of the PHD finger, whereas the adjacent groove accommodates Arg2. The two grooves are connected by a narrow channel, the small size of which defines the PHD finger’s specificity, excluding interactions with other modified histone peptides. Binding of the ING PHD fingers to H3K4me3 plays a critical role in regulating chromatin acetylation. The ING proteins function as tethering molecules that physically link the HDAC and HAT enzymatic complexes to chromatin. In this review we also highlight progress recently made in understanding the molecular basis underlying biological and tumorigenic activities of the ING tumor suppressors. PMID:19442115

Former WHK Intern Returns to NCI at Frederick as Earl-Stadtman Investigator | Poster

Cancer.gov

The Laboratory of Cell and Developmental Signaling (LCDS) recently welcomed John Brognard, Ph.D., as the new Earl-Stadtman Investigator. While Brognard is new to this role, he is not new to NCI at Frederick. In high school, Brognard was a Werner H. Kirsten Student Intern in what was formerly known as the ABL research program, where he worked under Bob Moschel, Ph.D., senior investigator, and Gary Pauly, Ph.D., currently a staff scientist in the Chemical Biology Laboratory.

Expression and characterization of duck enteritis virus gI gene

PubMed Central

2011-01-01

Background At present, alphaherpesviruses gI gene and its encoding protein have been extensively studied. It is likely that gI protein and its homolog play similar roles in virions direct cell-to-cell spread of alphaherpesviruses. But, little is known about the characteristics of DEV gI gene. In this study, we expressed and presented the basic properties of the DEV gI protein. Results The special 1221-bp fragment containing complete open reading frame(ORF) of duck enteritis virus(DEV) gI gene was extracted from plasmid pMD18-T-gI, and then cloned into prokaryotic expression vector pET-32a(+), resulting in pET-32a(+)-gI. After being confirmed by PCR, restriction endonuclease digestion and sequencing, pET-32a(+)-gI was transformed into E.coli BL21(DE3) competent cells for overexpression. DEV gI gene was successfully expressed by the addition of isopropyl-β-D-thiogalactopyranoside(IPTG). SDS-PAGE showed that the recombinant protein His6-tagged gI molecular weight was about 61 kDa. Subsequently, the expressed product was applied to generate specific antibody against gI protein. The specificity of the rabbit immuneserum was confirmed by its ability to react with the recombinant protein His6-tagged gI. In addition, real time-PCR was used to determine the the levels of the mRNA transcripts of gI gene, the results showed that the DEV gI gene was transcribed most abundantly during the late phase of infection. Furthermore, indirect immunofluorescence(IIF) was established to study the gI protein expression and localization in DEV-infected duck embryo fibroblasts (DEFs), the results confirmed that the protein was expressed and located in the cytoplasm of the infected cells, intensively. Conclusions The recombinant prokaryotic expression vector of DEV gI gene was constructed successfully. The gI protein was successfully expressed by E.coli BL21(DE3) and maintained its antigenicity very well. The basic information of the transcription and intracellular localization of gI gene were presented, that would be helpful to assess the possible role of DEV gI gene. The research will provide useful clues for further functional analysis of DEV gI gene. PMID:21595918

Modeling the Syn-Disposition of Nitrogen Donors in Non-Heme Diiron Enzymes. Synthesis, Characterization, and Hydrogen Peroxide Reactivity of Diiron(III) Complexes with the Syn N-Donor Ligand H2BPG2DEV

PubMed Central

Friedle, Simone; Kodanko, Jeremy J.; Morys, Anna J.; Hayashi, Takahiro; Moënne-Loccoz, Pierre; Lippard, Stephen J.

2009-01-01

In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H2BPG2DEV, that provides this geometric feature. The ligand incorporates biologically relevant carboxylate functionalities, which have not been explored as extensively as nitrogen-only analogs. Three novel oxo-bridged diiron(III) complexes [Fe2(μ-O)(H2O)2-(BPG2DEV)](ClO4)2 (6), [Fe2(μ-O)(μ-O CAriPrO)(BPG2DEV)](ClO4) (7), and [Fe2(μ-O)(μ-CO3)(BPG2DEV)] (8) were prepared. Single crystal X-ray structural characterization confirms that two pyridines are bound syn with respect to the Fe–Fe vector in these compounds. The carbonato-bridged complex 8 forms quantitatively from 6 in a rapid reaction with gaseous CO2 in organic solvents. A common maroon-colored intermediate (λmax = 490 nm; ε = 1500 M−1 cm−1) forms in reactions of 6, 7, or 8 with H2O2 and NEt3 in CH3CN/H2O solutions. Mass spectrometric analyses of this species, formed using 18O-labeled H2O2, indicate the presence of a peroxide ligand bound to the oxo-bridged diiron(III) center. The Mössbauer spectrum at 90 K of the EPR-silent intermediate exhibits a quadrupole doublet with δ. = 0.58 mm/s and ΔEQ = 0.58 mm/s. The isomer shift is typical for a peroxodiiron(III) species, but the quadrupole splitting parameter is unusually small compared to related complexes. These Mössbauer parameters are comparable to those observed for a peroxo intermediate formed in the reaction of reduced toluene/o-xylene monooxygenase hydroxylase (ToMOH) with dioxygen. Resonance Raman studies reveal an unusually low-energy O–O stretching mode in the peroxo intermediate that is consistent with a short diiron distance. Although peroxodiiron(III) intermediates generated from 6, 7, and 8 are poor O-atom transfer catalysts, they display highly efficient catalase activity, with turnover numbers up to 10,000. In contrast to hydrogen peroxide reactions of diiron(III) complexes that lack a dinucleating ligand, the intermediates generated here could be reformed in significant quantities after a second addition of H2O2, as observed spectroscopically and by mass spectrometry. PMID:19757795

Two-Dimensional Electronic-Vibrational Spectroscopy of Chlorophyll a and b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Nicholas H. C.; Fleming, Graham R.

2016-03-03

Presented are two-dimensional electronic-vibrational (2DEV) spectra of isolated chlorophyll a and b in deuterated ethanol. We excite the Q-band electronic transitions and measure the effects on the carbonyl and C=C double-bond stretch region of the infrared spectrum. With the aid of density functional theory calculations, we provide assignments for the major features of the spectrum. We show how the 2DEV spectra can be used to readily distinguish different solvation states of the chlorophyll, with features corresponding to the minority pentacoordinate magnesium (Mg) species being resolved along each dimension of the 2DEV spectra from the dominant hexacoordinate Mg species. These assignmentsmore » represent a crucial first step toward the application of 2DEV spectroscopy to chlorophyll-containing pigment-protein complexes.« less

77 FR 64812 - National Institute of General Medical Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-23

... Hilton Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Saraswathy Seetharam, Ph.D... Drive, Room 3An18K, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Brian R. Pike, Ph.D... Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

Effects of diesel exhaust on influenza-induced nasal inflammation

EPA Science Inventory

Title: Effects of Diesel Exhaust on Influenza-Induced Nasal Inflammation T L Noah, MD1,2, K Horvath, BS3, C Robinette, RN2, 0 Diaz Sanchez, PhD4 and I Jaspers, PhD1,2. 1UNC Dept. of Pediatrics, United States; 2UNC Center for Environmental Medicine, Asthma and Lung Biology, ...

Kashlev Named First Deputy Chief, GRCBL | Poster

Cancer.gov

By Nancy Parrish, Staff Writer Editor’s note: The text for this article was adapted from an e-mail announcement to the Center for Cancer Research community from Robert Wiltrout, Ph.D., on September 8, 2014. Robert Wiltrout, Ph.D., director, NCI Center for Cancer Research (CCR), recently announced the appointment of Mikhail Kashlev, Ph.D., to deputy chief of the Gene Regulation and Chromosome Biology Laboratory (GRCBL). The first deputy chief to be named in the GRCBL, Kashlev joins Jeff Strathern, Ph.D., GRCBL chief, in leading the laboratory in an active research environment that focuses on chromosome dynamics (recombination, chromosome segregation, and transposable elements) and regulation (transcription, silencing, and cell cycle control).

Regulation of ATM-Dependent DNA Damage Responses in Breast Cancer by the RhoGEF Net1

DTIC Science & Technology

2013-04-01

Science 279: 509-514. 5. Jaffe AB. et al., (2010) RhoGTPases: Biochemistry and Biology. Annu. Rev. Cell Dev. Biol. 21:247-269. 6. Rossman KL, et al...exchange factor Net1 is regulated by nuclear sequestration. J. Biol. Chem. 277:17, 14581-14588. 17. Harper JW, et al., (2007) The DNA Damage Response: Ten...Research (AACR) Annual Meeting and 2013 Annual Cancer Research Biochemistry Retreat Regulation of ATM-dependent DNA damage signaling in human breast

Paul Carlson | Center for Cancer Research

Cancer.gov

Paul Carlson, Ph.D. March 28 Principal Investigator Laboratory of Mucosal Pathogens and Cellular Immunology Center for Biologics Evaluation and Research (CBER), FDA Topic:  "Research and Regulation of novel biologic products at the FDA's Center for Biologics Evaluation and Research"

Carrie Eckert | NREL

Science.gov Websites

tools, gene knockout/expression, synthetic biology, Clustered Regularly Interspaced Short Palindromic Photosynthesis CO metabolism Education Ph.D., Molecular Biology, University of Colorado, Anschutz Campus, 2001 -2006 B.S., Biology, University of South Dakota, 1995-1999 Professional Experience Director, Center for

Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions.

PubMed

Swain, Lija; Wottawa, Marieke; Hillemann, Annette; Beneke, Angelika; Odagiri, Haruki; Terada, Kazutoyo; Endo, Motoyoshi; Oike, Yuichi; Farhat, Katja; Katschinski, Dörthe M

2014-09-01

On a molecular level, cells sense changes in oxygen availability through the PHDs, which regulate the protein stability of the α-subunit of the transcription factor HIF. Especially, PHD3 has been additionally associated with apoptotic cell death. We hypothesized that PHD3 plays a role in cell-fate decisions in macrophages. Therefore, myeloid-specific PHD3(-/-) mice were created and analyzed. PHD3(-/-) BMDM showed no altered HIF-1α or HIF-2α stabilization or increased HIF target gene expression in normoxia or hypoxia. Macrophage M1 and M2 polarization was unchanged likewise. Compared with macrophages from WT littermates, PHD3(-/-) BMDM exhibited a significant reduction in TUNEL-positive cells after serum withdrawal or treatment with stauro and SNAP. Under the same conditions, PHD3(-/-) BMDM also showed less Annexin V staining, which is representative for membrane disruption, and indicated a reduced early apoptosis. In an unbiased transcriptome screen, we found that Angptl2 expression was reduced in PHD3(-/-) BMDM under stress conditions. Addition of rAngptl2 rescued the antiapoptotic phenotype, demonstrating that it is involved in the PHD3-mediated response toward apoptotic stimuli in macrophages. © 2014 Society for Leukocyte Biology.

Activity Diagrams for DEVS Models: A Case Study Modeling Health Care Behavior

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozmen, Ozgur; Nutaro, James J

Discrete Event Systems Specification (DEVS) is a widely used formalism for modeling and simulation of discrete and continuous systems. While DEVS provides a sound mathematical representation of discrete systems, its practical use can suffer when models become complex. Five main functions, which construct the core of atomic modules in DEVS, can realize the behaviors that modelers want to represent. The integration of these functions is handled by the simulation routine, however modelers can implement each function in various ways. Therefore, there is a need for graphical representations of complex models to simplify their implementation and facilitate their reproduction. In thismore » work, we illustrate the use of activity diagrams for this purpose in the context of a health care behavior model, which is developed with an agent-based modeling paradigm.« less

Epigenetic Mediation of Endocrine and Immune Response in an Animal Model of Gulf War Illness

DTIC Science & Technology

2016-10-01

Illness 5b. GRANT NUMBER W81XWH-14-1-0550 5c. PROGRAM ELEMENT NUMBER Patrick O. McGowan, PhD, Gordon Broderick , PhD, James O’Callaghan, PhD...Nova Southeastern) as part of IAME/CFS meeting, hosted by Nova, to meet with Drs. Broderick (Co-PI) Oct 27- 2016. Co-PI and PI arranged to meet with...project. Direct supervision of molecular biology studies related to epigenetics data. Funding Support: Name: Gordon Broderick , PhD Project Role: Co

Dielectric elastomer vibrissal system for active tactile sensing

NASA Astrophysics Data System (ADS)

Conn, Andrew T.; Pearson, Martin J.; Pipe, Anthony G.; Welsby, Jason; Rossiter, Jonathan

2012-04-01

Rodents are able to dexterously navigate confined and unlit environments by extracting spatial and textural information with their whiskers (or vibrissae). Vibrissal-based active touch is suited to a variety of applications where vision is occluded, such as search-and-rescue operations in collapsed buildings. In this paper, a compact dielectric elastomer vibrissal system (DEVS) is described that mimics the vibrissal follicle-sinus complex (FSC) found in rodents. Like the vibrissal FSC, the DEVS encapsulates all sensitive mechanoreceptors at the root of a passive whisker within an antagonistic muscular system. Typically, rats actively whisk arrays of macro-vibrissae with amplitudes of up to +/-25°. It is demonstrated that these properties can be replicated by exploiting the characteristic large actuation strains and passive compliance of dielectric elastomers. A prototype DEVS is developed using VHB 4905 and embedded strain gauges bonded to the root of a tapered whisker. The DEVS is demonstrated to produce a maximum rotational output of +/-22.8°. An electro-mechanical model of the DEVS is derived, which incorporates a hyperelastic material model and Euler- Bernoulli beam equations. The model is shown to predict experimental measurements of whisking stroke amplitude and whisker deflection.

78 FR 42935 - Marine Mammals; File No. 16992

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... permit has been issued to Paul Nachtigall, Ph.D., Hawaii Institute of Marine Biology, University of... captivity at the Hawaii Institute of Marine Biology in Kaneohe, Hawaii. Researchers will conduct hearing...

A Study to Identify the Transitional Training Needs for United States Army Medical Residents

DTIC Science & Technology

1988-07-29

34 workshops in the earlv 1970s, the issues cOn tinleld to have onlv ma rg ina l interests from teach ing inst itut ions for nearlv a decade. In 1982, the...Perspectives ( PRO VIEWS): These were presentations typically given by senior physicians who occupy positions of considerable administrative...n) JCAHO std day PRO -VIFW! %td dev I NE-VIEWS std dev qPAD-VIEWS std dev CAREI std oev Family Pract 27 3.4074 0 95 35769 I 12 36296 095 35185 1.03 3

Framework for automatic information extraction from research papers on nanocrystal devices.

PubMed

Dieb, Thaer M; Yoshioka, Masaharu; Hara, Shinjiro; Newton, Marcus C

2015-01-01

To support nanocrystal device development, we have been working on a computational framework to utilize information in research papers on nanocrystal devices. We developed an annotated corpus called " NaDev" (Nanocrystal Device Development) for this purpose. We also proposed an automatic information extraction system called "NaDevEx" (Nanocrystal Device Automatic Information Extraction Framework). NaDevEx aims at extracting information from research papers on nanocrystal devices using the NaDev corpus and machine-learning techniques. However, the characteristics of NaDevEx were not examined in detail. In this paper, we conduct system evaluation experiments for NaDevEx using the NaDev corpus. We discuss three main issues: system performance, compared with human annotators; the effect of paper type (synthesis or characterization) on system performance; and the effects of domain knowledge features (e.g., a chemical named entity recognition system and list of names of physical quantities) on system performance. We found that overall system performance was 89% in precision and 69% in recall. If we consider identification of terms that intersect with correct terms for the same information category as the correct identification, i.e., loose agreement (in many cases, we can find that appropriate head nouns such as temperature or pressure loosely match between two terms), the overall performance is 95% in precision and 74% in recall. The system performance is almost comparable with results of human annotators for information categories with rich domain knowledge information (source material). However, for other information categories, given the relatively large number of terms that exist only in one paper, recall of individual information categories is not high (39-73%); however, precision is better (75-97%). The average performance for synthesis papers is better than that for characterization papers because of the lack of training examples for characterization papers. Based on these results, we discuss future research plans for improving the performance of the system.

Theory of quantized systems: formal basis for DEVS/HLA distributed simulation environment

NASA Astrophysics Data System (ADS)

Zeigler, Bernard P.; Lee, J. S.

1998-08-01

In the context of a DARPA ASTT project, we are developing an HLA-compliant distributed simulation environment based on the DEVS formalism. This environment will provide a user- friendly, high-level tool-set for developing interoperable discrete and continuous simulation models. One application is the study of contract-based predictive filtering. This paper presents a new approach to predictive filtering based on a process called 'quantization' to reduce state update transmission. Quantization, which generates state updates only at quantum level crossings, abstracts a sender model into a DEVS representation. This affords an alternative, efficient approach to embedding continuous models within distributed discrete event simulations. Applications of quantization to message traffic reduction are discussed. The theory has been validated by DEVSJAVA simulations of test cases. It will be subject to further test in actual distributed simulations using the DEVS/HLA modeling and simulation environment.

Young Kim, PhD | Division of Cancer Prevention

Cancer.gov

Young S Kim, PhD, joined the Division of Cancer Prevention at the National Cancer Institute in 1998 as a Program Director who oversees and monitors NCI grants in the area of Nutrition and Cancer. She serves as an expert in nutrition, molecular biology, and genomics as they relate to cancer prevention. Dr. Kim assists with research initiatives that will advance nutritional

78 FR 21112 - Marine Mammals; File Nos. 16992 and 14535

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

... hereby given that (1) Paul Nachtigall, Ph.D., Hawaii Institute of Marine Biology, University of Hawaii, P... (Pseudorca crassidens) maintained in captivity at the Hawaii Institute of Marine Biology in Kaneohe, HI...

Knowledge base and functionality of concepts of some Filipino biology teachers in five biology topics

NASA Astrophysics Data System (ADS)

Barquilla, Manuel B.

2018-01-01

This mixed research, is a snapshot of some Filipino Biology teachers' knowledge structure and how their concepts of the five topics in Biology (Photosynthesis, Cellular Respiration, human reproductive system, Mendelian genetics and NonMendelian genetics) functions and develops inside a biology classroom. The study focuses on the six biology teachers and a total of 222 students in their respective classes. Of the Six (6) teachers, three (3) are under the Science curriculum and the other three (3) are under regular curriculum in both public and private schools in Iligan city and Lanao del Norte, Philippines. The study utilized classroom discourses, concept maps, interpretative case-study method, bracketing method, and concept analysis for qualitative part; the quantitative part uses a nonparametric statistical tool, Kendall's tau Coefficient for determining relationship and congruency while measures of central tendencies and dispersion (mean, and standard deviation) for concept maps scores interpretation. Knowledge Base of Biology teachers were evaluated by experts in field of specialization having a doctorate program (e.g. PhD in Genetics) and PhD Biology candidates. The data collection entailed seven (7) months immersion: one (1) month for preliminary phase for the researcher to gain teachers' and students' confidence and the succeeding six (6) months for main observation and data collection. The evaluation of teachers' knowledge base by experts indicated that teachers' knowledge of (65%) is lower than the minimum (75%) recommended by ABD-el-Khalick and Boujaoude (1997). Thus, the experts believe that content knowledge of the teachers is hardly adequate for their teaching assignment. Moreover, the teachers in this study do not systematically use reallife situation to apply the concepts they teach. They can identify concepts too abstract for their student; however, they seldom use innovative ways to bring the discussion to their students' level of readiness and capacity to learn. Kendall's Tau Coefficient of agreement indicated that there is an agreement of the rating by experts and PhD (Biology) candidates. As for recommended level for teaching based on the respondent content knowledge structure, the experts and the PhD (Biology) candidates agree that the content knowledge of the teachers is at the borderline (rating of 6) between elementary and high school. These results imply that biology teachers need in-service training to upgrade their content knowledge in the subject. At the same time, the pre-service curriculum for biology teachers needs upgrading.

In vivo evaluation of virtual electrode mapping and ablation utilizing a direct endocardial visualization ablation catheter.

PubMed

Chik, William W B; Barry, M A; Malchano, Zach; Wylie, Bryan; Pouliopoulos, Jim; Huang, Kaimin; Lu, Juntang; Thavapalachandran, Sujitha; Robinson, David; Saadat, Vahid; Thomas, Stuart P; Ross, David L; Kovoor, Pramesh; Thiagalingam, Aravinda

2012-01-01

Radiofrequency (RF) ablation utilizing direct endocardial visualization (DEV) requires a "virtual electrode" to deliver RF energy while preserving visualization. This study aimed to: (1) examine the virtual electrode RF ablation efficacy; (2) determine the optimal power and duration settings; and (3) evaluate the utility of virtual electrode unipolar electrograms. The DEV catheter lesions were compared to lesions formed using a 3.5 mm open irrigated tip catheter within the right atria of 12 sheep. Generator power settings for DEV were titrated from 12W, 14W and 16W for 20, 30 and 40 seconds duration with 25 mL/min saline irrigation. Standard irrigated tip catheter settings of 30W, 50°C for 30 seconds and 30 mL/min were used. The DEV lesions were significantly greater in surface area and both major and minor axes compared to irrigated tip lesions (surface area 19.43 ± 9.09 vs 10.88 ± 4.72 mm, P<0.01) with no difference in transmurality (93/94 vs 46/47) or depth (1.86 ± 0.75 vs 1.85 ± 0.57 mm). Absolute electrogram amplitude reduction was greater for DEV lesions (1.89 ± 1.31 vs 1.49 ± 0.78 mV, P = 0.04), but no difference in percentage reduction. Pre-ablation pacing thresholds were not different between DEV (0.79 ± 0.36 mA) and irrigated tip (0.73 ± 0.25 mA) lesions. There were no complications noted during ablation with either catheter. Virtual electrode ablation consistently created wider lesions at lower power compared to irrigated tip ablation. Virtual electrode electrograms showed a comparable pacing and sensing efficacy in detecting local myocardial electrophysiological changes. © 2011 Wiley Periodicals, Inc.

Soluble Factors Released by Endogenous Viable Cells Enhance the Antioxidant and Chemoattractive Activities of Cryopreserved Amniotic Membrane

PubMed Central

Duan-Arnold, Yi; Gyurdieva, Alexandra; Johnson, Amy; Jacobstein, Douglas A.; Danilkovitch, Alla

2015-01-01

Objective: Regulation of oxidative stress and recruitment of key cell types are activities of human amniotic membrane (hAM) that contribute to its benefits for wound treatment. Progress in tissue preservation has led to commercialization of hAM. The majority of hAM products are devitalized with various degrees of matrix alteration. Data show the importance of hAM matrix preservation, but little is known about the advantages of retaining viable endogenous cells. In this study, we compared the antioxidant and chemoattractive properties of viable intact cryopreserved hAM (int-hAM) and devitalized cryopreserved hAM (dev-hAM) to determine the benefits of cell preservation. Approach: We evaluated the ability of int-hAM and dev-hAM to protect fibroblasts from oxidant-induced cell damage, to suppress oxidants, and to recruit fibroblasts and keratinocytes in vitro. Results: Both the int-hAM–derived conditioned medium (CM) and the int-hAM tissue rescued significantly more fibroblasts from oxidant-induced damage than dev-hAM (844% and 93% more, respectively). The int-hAM CM showed a 202% greater antioxidant capacity than dev-hAM. The int-hAM CM enhanced the recruitment of fibroblasts and normal and diseased keratinocytes to a greater extent than dev-hAM (1,555%, 315%, and 151% greater, respectively). Innovation and Conclusion: Int-hAM, in which all native components are preserved, including endogenous viable cells, demonstrated a significantly greater antioxidant and fibroblast and keratinocyte chemoattractive potential compared to dev-hAM, in which viable cells are destroyed. The release of soluble factors that protect fibroblasts from oxidative injury by hAM containing viable cells is a mechanism of hAM antioxidant activity, which is a novel finding of this study. PMID:26029483

CCR researchers identify pathway critical for preventing premature aging | Center for Cancer Research

Cancer.gov

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal disease in which patients age prematurely. To identify primary HGPS driver mechanisms, Nard Kubben, Ph.D., a Research Fellow in the laboratory of Tom Misteli, Ph.D., in CCR’s Laboratory of Receptor Biology and Gene Expression, and colleagues in the NCI High-throughput Imaging Facility developed an imaging-based

Biological Approach to System Information Security (BASIS)

DTIC Science & Technology

2003-12-01

Expertise J. Giordano Dr. Popyack AFRL 7 - Computer Engineering, provided by Douglas Summerville, Ph.D., Assistant Professor of the Department of...Skormin, Ph.D., Principal Investigator, Professor, Electrical and Computer Engineering, Binghamton University In addition, Joseph Giordano and Dr...worm was written by Robert Morris in 1988. But the greatest epidemics took place recently: " Melissa " in spring of 1999 and "Love Letter" in spring

Researchers Study Strategies to Preserve Hearing | NIH MedlinePlus the Magazine

MedlinePlus

... L. Cunningham, PhD, Chief, Section on Sensory Cell Biology Photo Courtesy of: NIDCD An estimated half million ... Dr. Lisa Cunningham, Chief, Section on Sensory Cell Biology, spoke with NIH MedlinePlus magazine about the research. ...

Jeffrey Strathern Retires After More Than Three Decades at NCI | Poster

Cancer.gov

Jeffrey Strathern, Ph.D., has hung up his lab coat and donned a sailor’s cap after 32 years of advancing science in areas such as genetics and genomics, chromosome biology, molecular biology, and biochemistry.

Near-Earth Asteroid Prospector and the Commercial Development of Space Resources

NASA Astrophysics Data System (ADS)

Benson, Jim

1998-01-01

With the recent bad news that there may be little or no budget money for NASA to continue funding programs aimed at the human exploration of space beyond Earth's orbit, it becomes even more important for other initiatives to be considered. SpaceDev is the world' s first commercial space exploration company, and enjoys the strong support of Dan Goldin, Wes Huntress, Carl Pilcher, Alan Ladwig, and others at NASA headquarters. SpaceDev is also supported by such scientists as Jim Arnold, Paul Coleman, John Lewis, Steve Ostro, and many others. Taxpayers cannot be expected to carry the entire burden of exploration, construction, and settlement. The private sector must be involved, and the SpaceDev Near Earth Asteroid Prospector (NEAP) venture may provide a good example of how governments and the private sector can cooperate to accomplish these goals. SpaceDev believes that the utilization of in situ resources will take place on near-Earth asteroids before the Moon or Mars because many NEOs are energetically closer than the Moon or Mars and have a highly concentrated composition. SpaceDev currently expects to perform the following three missions: NEAP (science data gathering); NEAP 2, near-Earth asteroid or short-term comet sample return mission; and NEAP 3, in situ fuel production or resource extraction and utilization. These missions could pioneer the way for in situ resources for construction.

CINRG: Systems Biology of Glucocorticoids in Muscle Disease

DTIC Science & Technology

2012-10-01

Duchenne Muscular dystrophy , Glucocorticoids, Systems biology, Drug mechanism CINRG: Systems Biology of Glucocorticoids in Muscle Disease Zuyi Wang, Ph.D...2011-2012) for Contract W81XWH-09-1-0726 SYSTEMS BIOLOGY OF GLUCOCORTICOIDS IN MUSCLE DISEASE Introduction Duchenne muscular dystrophy ...DMD) is the most common and incurable muscular dystrophy of childhood. Muscle regeneration fails with advancing age, leading to considerable fibrosis

Transformation of TNT by Aquatic Plants,

DTIC Science & Technology

1996-01-01

ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Department of Environmental Science and Engineering N/A George R. Brown School of Engineering Rice...Department of Environmental Science and Engineering at Rice University, Dr. Hughes teaches courses in Water and Wastewater Treatment, Biological Process...8:55 Chairperson’s Opening Remarks 1:40 Chairperson’s Remarks Alan J. M. Baker Ph.D., Reader in Environmental Science & Alan J. M. Baker, Ph.D

imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel

USDA-ARS?s Scientific Manuscript database

Interactive modules for data exploration and visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data sets with a user-friendly interface. Individual modules were designed to provide toolsets to enable interactive ...

Information Ubiquity in Austere Locations

DTIC Science & Technology

2011-01-01

are incompatible (e.g., GSM vs. CDMA ), or are insecure for one’s purposes. There might be satellite communi- cations, but its access might be...Ave. Latency (Unloaded) Ave. Latency (Overloaded) Std Dev. (Unloaded) Std Dev. (Overloaded) M ill is ec on ds AOI UAV UAV 1 UAV 2 UAV 3 Joseph

Repair of Neocortex in a Model of Cortical Dysplasia

DTIC Science & Technology

2007-03-27

236. Dang L, Yoon K, Wang M, Gaiano N. 2006. Notch3 signaling promotes radial glial/progenitor character in the Mammalian telencephalon. Dev Neurosci...2006) Notch3 signaling promotes radial glial/progenitor character in the Mammalian telencephalon. Dev Neurosci 28:58- 69. Desai AR, McConnell SK (2000

Ludwig von Bertalanffy's Organismic View on the Theory of Evolution

PubMed Central

Drack, Manfred

2015-01-01

Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 77–90, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:25727202

Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism for Hormonal Resistance in Breast Cancer.

DTIC Science & Technology

1999-06-01

Department of Biochemistry and Molecular Biology at Cornell University in Ithaca, NY. Dr. Gwendal Lazennec, a Postdoctoral Researcher on this work...Ph.D.) En, Julie Hoeksema, Jason Keller, Anne Kraus, William Lee (Ph.D.) Krueger, Kristopher Lazennec, Gwendal (Ph.D.) Mclnerney, Eileen (Ph.D...Receptors Containing Amino Acid Substitutions for Tyrosine 537 in the Receptor Protein Karen E. Weis, Kirk Ekena, James A. Thomas, Gwendal Lazennec

Information Use by PhD Students in Agriculture and Biology: A Dissertation Citation Analysis

ERIC Educational Resources Information Center

Kuruppu, Pali U.; Moore, Debra C.

2008-01-01

This article reports the findings of a study conducted to examine the types of information used by graduate students in the fields of biological and agricultural sciences at Iowa State University (ISU). The citations of doctoral dissertations submitted in nine agriculture and biological science subject fields (crop production and physiology;…

Alida Gerritsen | NREL

Science.gov Websites

research, such as proteomics and metabolomics, in order to develop a greater understanding of the organisms used for renewable energy resources. Research Interests Bioinformatics Novel analysis pipelines Education Ph.D., Evolutionary Biology, University of Oregon B.S., Biology, St. Lawrence University

Duck Enteritis Virus Glycoprotein D and B DNA Vaccines Induce Immune Responses and Immunoprotection in Pekin Ducks

PubMed Central

Zhao, Yan; Cao, Yongsheng; Cui, Lihong; Ma, Bo; Mu, Xiaoyu; Li, Yanwei; Zhang, Zhihui; Li, Dan; Wei, Wei; Gao, Mingchun; Wang, Junwei

2014-01-01

DNA vaccine is a promising strategy for protection against virus infection. However, little is known on the efficacy of vaccination with two plasmids for expressing the glycoprotein D (gD) and glycoprotein B (gB) of duck enteritis virus (DEV) in inducing immune response and immunoprotection against virulent virus infection in Pekin ducks. In this study, two eukaryotic expressing plasmids of pcDNA3.1-gB and pcDNA3.1-gD were constructed. Following transfection, the gB and gD expressions in DF1 cells were detected. Groups of ducks were vaccinated with pcDNA3.1-gB and/or pcDNA3.1-gD, and boosted with the same vaccine on day 14 post primary vaccination. We found that intramuscular vaccinations with pcDNA3.1-gB and/or pcDNA3.1-gD, but not control plasmid, stimulated a high frequency of CD4+ and CD8+ T cells in Pekin ducks, particularly with both plasmids. Similarly, vaccination with these plasmids, particularly with both plasmids, promoted higher levels of neutralization antibodies against DEV in Pekin ducks. More importantly, vaccination with both plasmids significantly reduced the virulent DEV-induced mortality in Pekin ducks. Our data indicated that vaccination with plasmids for expressing both gB and gD induced potent cellular and humoral immunity against DEV in Pekin ducks. Therefore, this vaccination strategy may be used for the prevention of DEV infection in Pekin ducks. PMID:24736466

Duck enteritis virus glycoprotein D and B DNA vaccines induce immune responses and immunoprotection in Pekin ducks.

PubMed

Zhao, Yan; Cao, Yongsheng; Cui, Lihong; Ma, Bo; Mu, Xiaoyu; Li, Yanwei; Zhang, Zhihui; Li, Dan; Wei, Wei; Gao, Mingchun; Wang, Junwei

2014-01-01

DNA vaccine is a promising strategy for protection against virus infection. However, little is known on the efficacy of vaccination with two plasmids for expressing the glycoprotein D (gD) and glycoprotein B (gB) of duck enteritis virus (DEV) in inducing immune response and immunoprotection against virulent virus infection in Pekin ducks. In this study, two eukaryotic expressing plasmids of pcDNA3.1-gB and pcDNA3.1-gD were constructed. Following transfection, the gB and gD expressions in DF1 cells were detected. Groups of ducks were vaccinated with pcDNA3.1-gB and/or pcDNA3.1-gD, and boosted with the same vaccine on day 14 post primary vaccination. We found that intramuscular vaccinations with pcDNA3.1-gB and/or pcDNA3.1-gD, but not control plasmid, stimulated a high frequency of CD4+ and CD8+ T cells in Pekin ducks, particularly with both plasmids. Similarly, vaccination with these plasmids, particularly with both plasmids, promoted higher levels of neutralization antibodies against DEV in Pekin ducks. More importantly, vaccination with both plasmids significantly reduced the virulent DEV-induced mortality in Pekin ducks. Our data indicated that vaccination with plasmids for expressing both gB and gD induced potent cellular and humoral immunity against DEV in Pekin ducks. Therefore, this vaccination strategy may be used for the prevention of DEV infection in Pekin ducks.

Framework for automatic information extraction from research papers on nanocrystal devices

PubMed Central

Yoshioka, Masaharu; Hara, Shinjiro; Newton, Marcus C

2015-01-01

Summary To support nanocrystal device development, we have been working on a computational framework to utilize information in research papers on nanocrystal devices. We developed an annotated corpus called “ NaDev” (Nanocrystal Device Development) for this purpose. We also proposed an automatic information extraction system called “NaDevEx” (Nanocrystal Device Automatic Information Extraction Framework). NaDevEx aims at extracting information from research papers on nanocrystal devices using the NaDev corpus and machine-learning techniques. However, the characteristics of NaDevEx were not examined in detail. In this paper, we conduct system evaluation experiments for NaDevEx using the NaDev corpus. We discuss three main issues: system performance, compared with human annotators; the effect of paper type (synthesis or characterization) on system performance; and the effects of domain knowledge features (e.g., a chemical named entity recognition system and list of names of physical quantities) on system performance. We found that overall system performance was 89% in precision and 69% in recall. If we consider identification of terms that intersect with correct terms for the same information category as the correct identification, i.e., loose agreement (in many cases, we can find that appropriate head nouns such as temperature or pressure loosely match between two terms), the overall performance is 95% in precision and 74% in recall. The system performance is almost comparable with results of human annotators for information categories with rich domain knowledge information (source material). However, for other information categories, given the relatively large number of terms that exist only in one paper, recall of individual information categories is not high (39–73%); however, precision is better (75–97%). The average performance for synthesis papers is better than that for characterization papers because of the lack of training examples for characterization papers. Based on these results, we discuss future research plans for improving the performance of the system. PMID:26665057

Gayle Bentley | NREL

Science.gov Websites

Areas of Expertise Metabolic engineering Synthetic biology Molecular microbiology Gas chromatography biosynthesis Education Ph.D., Molecular Microbiology and Microbial Pathogenesis, Washington University in St

2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories.

PubMed

2012-04-01

Third Edition [Formula: see text] [Box: see text] Printed with permission from the International Society for Biological and Environmental Repositories (ISBER) © 2011 ISBER All Rights Reserved Editor-in-Chief Lori D. Campbell, PhD Associate Editors Fay Betsou, PhD Debra Leiolani Garcia, MPA Judith G. Giri, PhD Karen E. Pitt, PhD Rebecca S. Pugh, MS Katherine C. Sexton, MBA Amy P.N. Skubitz, PhD Stella B. Somiari, PhD Individual Contributors to the Third Edition Jonas Astrin, Susan Baker, Thomas J. Barr, Erica Benson, Mark Cada, Lori Campbell, Antonio Hugo Jose Froes Marques Campos, David Carpentieri, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Keith Harding, Edward Kaercher, Joseph Kessler, Sarah Loud, Hannah Maynor, Kevin McCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, James O'Sullivan, Karen Pitt, Rebecca Pugh, Rivka Ravid, Katherine Sexton, Ricardo Luis A. Silva, Frank Simione, Amy Skubitz, Stella Somiari, Frans van der Horst, Gavin Welch, Andy Zaayenga 2012 Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOSITORIES (ISBER) INTRODUCTION T he availability of high quality biological and environmental specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens that will enable their future use. Sharing successful strategies for accomplishing this goal is one of the driving forces for the International Society for Biological and Environmental Repositories (ISBER). For more information about ISBER see www.isber.org . ISBER's Best Practices for Repositories (Best Practices) reflect the collective experience of its members and has received broad input from other repository professionals. Throughout this document effective practices are presented for the management of specimen collections and repositories. The term "Best Practice" is used in cases where a level of operation is indicated that is above the basic recommended practice or more specifically designates the most effective practice. It is understood that repositories in certain locations or with particular financial constraints may not be able to adhere to each of the items designated as "Best Practices". Repositories fitting into either of these categories will need to decide how they might best adhere to these recommendations within their particular circumstances. While adherence to ISBER Best Practices is strictly on a voluntary basis, it is important to note that some aspects of specimen management are governed by national/federal, regional and local regulations. The reader should refer directly to regulations for their national/federal, regional and local requirements, as appropriate. ISBER has strived to include terminology appropriate to the various specimen types covered under these practices, but here too, the reader should take steps to ensure the appropriateness of the recommendations to their particular repository type prior to the implementation of any new approaches. Important terms within the document are italicized when first used in a section and defined in the glossary. The ISBER Best Practices are periodically reviewed and revised to reflect advances in research and technology. The third edition of the Best Practices builds on the foundation established in the first and second editions which were published in 2005 and 2008, respectively.

Jeffery G. Linger | NREL

Science.gov Websites

development Metabolic engineering Fundamental molecular biology and genetics Education Ph.D., Biochemistry and Molecular Genetics, University of Colorado School of Medicine, 2006 B.S., Environmental, Population, and . Specifically, Linger uses molecular biology techniques to assess the feasibility of converting the

Life on the borders

NASA Astrophysics Data System (ADS)

Barry, Edward

2010-02-01

Interdisciplinary science has been a hot topic for more than a decade, with increasing numbers of researchers working on projects that do not fit into neat departmental boxes like "physics" or "biology". Yet despite this increased activity, the structures in place to support these interdisciplinary scientists - including research grants and training for PhD students - have sometimes lagged behind. One programme that aims to help fill this gap for students of biomedical, physical and computational sciences is the Interfaces Initiative, a joint project of the Howard Hughes Medical Institute and the US National Institute of Biomedical Imaging and Bioengineering. Physics World talked to a current Interfaces participant, Edward Barry, who is finishing his PhD in biology-related condensed-matter physics at Brandeis University in Massachusetts.

Genome-Wide Identification of the PHD-Finger Family Genes and Their Responses to Environmental Stresses in Oryza sativa L.

PubMed Central

Sun, Mingzhe; Yang, Junkai; Cui, Na; Zhu, Yanming

2017-01-01

The PHD-finger family has been demonstrated to be involved in regulating plant growth and development. However, little information is given for its role in environmental stress responses. Here, we identified a total of 59 PHD family genes in the rice genome. These OsPHDs genes were located on eleven chromosomes and synteny analysis only revealed nine duplicated pairs within the rice PHD family. Phylogenetic analysis of all OsPHDs and PHDs from other species revealed that they could be grouped into two major clusters. Furthermore, OsPHDs were clustered into eight groups and members from different groups displayed a great divergence in terms of gene structure, functional domains and conserved motifs. We also found that with the exception of OsPHD6, all OsPHDs were expressed in at least one of the ten tested tissues and OsPHDs from certain groups were expressed in specific tissues. Moreover, our results also uncovered differential responses of OsPHDs expression to environmental stresses, including ABA (abscisic acid), water deficit, cold and high Cd. By using quantitative real-time PCR, we further confirmed the differential expression of OsPHDs under these stresses. OsPHD1/7/8/13/33 were differentially expressed under water deficit and Cd stresses, while OsPHD5/17 showed altered expression under water deficit and cold stresses. Moreover, OsPHD3/44/28 displayed differential expression under ABA and Cd stresses. In conclusion, our results provide valuable information on the rice PHD family in plant responses to environmental stress, which will be helpful for further characterizing their biological roles in responding to environmental stresses.

Brief Report: Insistence on Sameness, Anxiety, and Social Motivation in Children with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Factor, Reina S.; Condy, Emma E.; Farley, Julee P.; Scarpa, Angela

2016-01-01

While the function of restricted repetitive behaviors (RRBs) in autism spectrum disorder (ASD) is unclear, RRBs may function as anxiety reduction strategies (Joosten et al. "J Autism Dev Disord" 39(3):521-531, 2009. Moreover, anxiety in ASD is associated with low social motivation (Swain et al. "J Autism Dev Disord," 2015. The…

Development of a Free-Electron Laser Center and Research in Medicine, Biology and Materials Science,

DTIC Science & Technology

1992-05-14

Elastin Production in Tissue Culture", Debra A.Gonzalez MD, David L. Zealear, PhD., J.M. Davidson, PhD., Robert H. Ossoff, MD, DMD , August 1990...Otolaryngoloty-Head and Neck Surgery. K. "CO2 Laser Micromanipulator Parallax Error Resolved, Jay Werkhaven,MD, Jerri Tribble, and Robert H. Ossoff, MD, DMD ...of the Upper Aerodigestive Tract, Robert H. Ossoff, MD, DMD , Al Aly, MD, Nick Houchin, AAS, and Debra Gonzalez, MD, Vanderbilt University, Nashville

Visually Tracking Translocations in Living Cells | Center for Cancer Research

Cancer.gov

Chromosomal translocations, the fusion of pieces of DNA from different chromosomes, are often observed in cancer cells and can even cause cancer. However, little is known about the dynamics and regulation of translocation formation. To investigate this critical process, Tom Misteli, Ph.D., in CCR’s Laboratory of Receptor Biology and Gene Expression, and his colleague Vassilis Roukos, Ph.D., developed a novel experimental system that allowed the researchers to see, for the first time, translocations form in individual, live cells.

Coxsackievirus B4 as a Causative Agent of Diabetes Mellitus Type 1: Is There a Role of Inefficiently Treated Drinking Water and Sewage in Virus Spreading?

PubMed

El-Senousy, Waled M; Abdel-Moneim, Adel; Abdel-Latif, Mahmoud; El-Hefnawy, Mohamed H; Khalil, Rehab G

2018-03-01

This study proposed to detect the enterovirus (EV) infection in children with type 1 diabetes mellitus (T1D) and to assess the role of insufficiently treated water and sewage as sources of viral spreading. Three hundred and eighty-two serum specimens of children with T1D, one hundred serum specimens of children who did not suffer from T1D as control, and forty-eight water and sewage samples were screened for EV RNA using nested RT-PCR. The number of genome copies and infectious units of EVs in raw and treated sewage and water samples were investigated using real-time (RT)-PCR and plaque assay, respectively. T1D markers [Fasting blood glucose (FBG), HbA1c, and C-peptide], in addition to anti-Coxsackie A & B viruses (CVs A & B) IgG, were measured in control, T1D-negative EV (T1D-EV - ), and T1D-positive EV (T1D-EV + ) children specimens. The prevalence of EV genome was significantly higher in diabetic children (26.2%, 100 out of 382) than the control children (0%, 0 out of 100). FBG and HbA1c in T1D-EV - and T1D-EV + children specimens were significantly higher than those in the control group, while c-peptide in T1D-EV - and T1D-EV + children specimens was significantly lower than that in the control (n = 100; p < 0.001). Positivity of anti-CVs A & B IgG was 70.7, 6.7, and 22.9% in T1D-EV + , T1D-EV - , and control children specimens, respectively. The prevalence of EV genome in drinking water and treated sewage samples was 25 and 33.3%, respectively. The prevalence of EV infectious units in drinking water and treated sewage samples was 8.5 and 25%, respectively. Quantification assays were performed to assess the capabilities of both wastewater treatment plants (WWTPs) and water treatment plants (WTPs) to remove EV. The reduction of EV genome in Zenin WWTP ranged from 2 to 4 log 10 , while the reduction of EV infectious units ranged from 1 to 4 log 10 . The reduction of EV genome in El-Giza WTP ranged from 1 to 3 log 10 , while the reduction of EV infectious units ranged from 1 to 2 log 10 . This capability of reduction did not prevent the appearance of infectious EV in treated sewage and drinking water. Plaque purification was performed for isolation of separate EV isolates from treated and untreated water and sewage samples. Characterization of the EV amplicons by RT-PCR followed by sequencing of these isolates revealed high homology (97%) with human coxsackievirus B4 (CV B4) in 60% of the isolates, while the rest of the isolates belonged to poliovirus type 1 and type 2 vaccine strains. On the other hand, characterization of the EV amplicons by RT-PCR followed by sequencing for T1D-EV + children specimens indicated that all samples contained CV B4 with the same sequence characterized in the environmental samples. CV B4-contaminated drinking water or treated sewage may play a role as a causative agent of T1D in children.

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.

PubMed

Wang, Gang G; Song, Jikui; Wang, Zhanxin; Dormann, Holger L; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J; Allis, C David

2009-06-11

Histone H3 lysine 4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities1. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

Christopher W. Johnson | NREL

Science.gov Websites

the marketplace. Education Ph.D., Molecular Biology, University of Colorado - Anschutz Medical Campus , NREL, NBC, 2015-present Postdoctoral Researcher, NREL, NBC, 2012-2015 Molecular Biologist, Gevo, 2011

40 CFR Table F-3 to Subpart F of... - Critical Parameters of Idealized Ambient Particle Size Distributions

Code of Federal Regulations, 2010 CFR

2010-07-01

... Ambient Particle Size Distributions F Table F-3 to Subpart F of Part 53 Protection of Environment... Ambient Particle Size Distributions Idealized Distribution Fine Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) Coarse Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) PM2.5/PM10 Ratio FRM Sampler...

40 CFR Table F-3 to Subpart F of... - Critical Parameters of Idealized Ambient Particle Size Distributions

Code of Federal Regulations, 2013 CFR

2013-07-01

... Ambient Particle Size Distributions F Table F-3 to Subpart F of Part 53 Protection of Environment... Ambient Particle Size Distributions Idealized Distribution Fine Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m 3) Coarse Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m 3) PM 2.5/PM 10 Ratio FRM Sampler...

40 CFR Table F-3 to Subpart F of... - Critical Parameters of Idealized Ambient Particle Size Distributions

Code of Federal Regulations, 2012 CFR

2012-07-01

... Ambient Particle Size Distributions F Table F-3 to Subpart F of Part 53 Protection of Environment... Ambient Particle Size Distributions Idealized Distribution Fine Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) Coarse Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) PM2.5/PM10 Ratio FRM Sampler...

40 CFR Table F-3 to Subpart F of... - Critical Parameters of Idealized Ambient Particle Size Distributions

Code of Federal Regulations, 2011 CFR

2011-07-01

... Ambient Particle Size Distributions F Table F-3 to Subpart F of Part 53 Protection of Environment... Ambient Particle Size Distributions Idealized Distribution Fine Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) Coarse Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) PM2.5/PM10 Ratio FRM Sampler...

40 CFR Table F-3 to Subpart F of... - Critical Parameters of Idealized Ambient Particle Size Distributions

Code of Federal Regulations, 2014 CFR

2014-07-01

... Ambient Particle Size Distributions F Table F-3 to Subpart F of Part 53 Protection of Environment... Ambient Particle Size Distributions Idealized Distribution Fine Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) Coarse Particle Mode MMD (µm) Geo. Std. Dev. Conc. (µg/m3) PM 2.5/PM 10 Ratio FRM Sampler...

U.S. Air Force Enlisted Accessions: Upgrading the Pipeline

DTIC Science & Technology

2010-02-17

of State Boards of Education (NASBE) and the Association for Career and Technical Education (ACTE). Specific collaboration efforts include improving...Accessions Command and the Association for Career and Technical Education . November 20, 2009. http://dev.armyedspace.com/news-updates/news...Understanding Between the U.S. Army Accessions Command and the Association for Career and Technical Education . November 20, 2009. http://dev.armyedspace.com

SLAC Phone Directory: Search Form

Science.gov Websites

Facilities LCLS Hard X-Ray LCLS IT & Networking LCLS IT Photon Systems LCLS Instrumentation Dev LCLS Delivery Dept LCLS Science Research & DevDiv LCLS Soft X-Ray LCLS Technical Support LCLS User Beam Line Ops Sup SSRL MSD Hard X-rays SSRL MSD Soft X-rays SSRL MSDBeam Line Elec SSRL MSDBeam Line

Indispensable Amino Acid-Deficient Diets Induce Seizures in Ketogenic Diet-Fed Rodents, Demonstrating a Role for Amino Acid Balance in Dietary Treatments for Epilepsy.

PubMed

Gietzen, Dorothy W; Lindström, Sarah H; Sharp, James W; Teh, Pok Swee; Donovan, Michael J

2018-03-01

Low protein amounts are used in ketogenic diets (KDs), where an essential (indispensable) amino acid (IAA) can become limiting. Because the chemically sensitive, seizurogenic, anterior piriform cortex (APC) is excited by IAA limitation, an imbalanced KD could exacerbate seizure activity. We questioned whether dietary IAA depletion worsens seizure activity in rodents fed KDs. In a series of 6 trials, male rats or gerbils of both sexes (6-8/group) were given either control diets (CDs) appropriate for each trial, a KD, or a threonine-devoid (ThrDev) diet for ≥7 d, and tested for seizures using various stimuli. Microchip analysis of rat APCs was also used to determine if changes in transcripts for structures relevant to seizurogenesis are affected by a ThrDev diet. Glutamate release was measured in microdialysis samples from APCs during the first meal after 7 d on a CD or a ThrDev diet. Adult rats showed increased susceptibility to seizures in both chemical (58%) and electroshock (doubled) testing after 7 d on a ThrDev diet compared with CD (each trial, P ≤ 0.05). Seizure-prone Mongolian gerbils had fewer seizures after receiving a KD, but exacerbated seizures (68%) after 1 meal of KD minus Thr (KD-T compared with CD, P < 0.05). In kindled rats fed KD-T, both counts (19%) and severities (77%) of seizures were significantly elevated (KD-T compared with CD, P < 0.05). Gene transcript changes were consistent with enhanced seizure susceptibility (7-21 net-fold increases, P = 0.045-0.001) and glutamate release into the APC was increased acutely (4-fold at 20 min, 2.6-fold at 60 min, P < 0.05) after 7 d on a ThrDev diet. Seizure severity in rats and gerbils was reduced after KDs and exacerbated by ThrDev, both in KD- and CD-fed animals, consistent with the mechanistic studies. We suggest that a complete protein profile in KDs may improve IAA balance in the APC, thereby lowering the risk of seizures.

Career Opportunities in Physiology: Careers for Physiologists in Departments of Biological and Animal Sciences.

ERIC Educational Resources Information Center

Gregg, Christine M.

1985-01-01

Analyzes data from an American Physiological Society survey on 88 physiology programs not associated with medical schools. Included are enrollment data and data on faculty characteristics, areas of specialization, and doctorates awarded. Indicates that the majority of physiology PhD programs are located within departments of biological sciences.…

The Notion of Scientific Knowledge in Biology

ERIC Educational Resources Information Center

Morante, Silvia; Rossi, Giancarlo

2016-01-01

The purpose of this work is to reconsider and critically discuss the conceptual foundations of modern biology and bio-sciences in general, and provide an epistemological guideline to help framing the teaching of these disciplines and enhancing the quality of their presentation in High School, Master and Ph.D. courses. After discussing the…

Molecular cell biology and advanced microscopy: an interview with Joshua Z. Rappoport.

PubMed

Rappoport, Joshua Z

2018-05-01

Dr Joshua Z Rappoport, PhD, speaks to Nawsheen Boodhun, Managing Editor. Rappoport completed his bachelor's degree in Biology at Brown University (RI, USA). He then went on to earn a PhD from the Program in Mechanisms of Disease and Therapeutics at the Mount Sinai School of Medicine Graduate School of Biological Sciences of New York University (USA). Rappoport spent the early parts of his career working as a postdoctoral researcher at the Laboratory of Cellular Biophysics based in The Rockefeller University (NY, USA). He was subsequently recruited as a tenured faculty member to work as part of the School of Biosciences at the University of Birmingham (UK). 2014 marked the return of Rappoport to the USA, where he is currently a Research Professor in Molecular Cell Biology at the Northwestern University Feinberg School of Medicine (IL, USA). He is also the Director of the Center for Advanced Microscopy (CAM) and Nikon Imaging Center (NIC), a large core facility consisting of eight members of staff that support around 200 different laboratories.

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

DOE Office of Scientific and Technical Information (OSTI.GOV)

E Rajakumara; Z Wang; H Ma

2011-12-31

Histone methylation occurs on both lysine and arginine residues, and its dynamic regulation plays a critical role in chromatin biology. Here we identify the UHRF1 PHD finger (PHD{sub UHRF1}), an important regulator of DNA CpG methylation, as a histone H3 unmodified arginine 2 (H3R2) recognition modality. This conclusion is based on binding studies and cocrystal structures of PHD{sub UHRF1} bound to histone H3 peptides, where the guanidinium group of unmodified R2 forms an extensive intermolecular hydrogen bond network, with methylation of H3R2, but not H3K4 or H3K9, disrupting complex formation. We have identified direct target genes of UHRF1 from microarraymore » and ChIP studies. Importantly, we show that UHRF1's ability to repress its direct target gene expression is dependent on PHD{sub UHRF1} binding to unmodified H3R2, thereby demonstrating the functional importance of this recognition event and supporting the potential for crosstalk between histone arginine methylation and UHRF1 function.« less

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rajakumara, Eerappa; Wang, Zhentian; Ma, Honghui

2011-08-29

Histone methylation occurs on both lysine and arginine residues, and its dynamic regulation plays a critical role in chromatin biology. Here we identify the UHRF1 PHD finger (PHD{sub UHRF1}), an important regulator of DNA CpG methylation, as a histone H3 unmodified arginine 2 (H3R2) recognition modality. This conclusion is based on binding studies and cocrystal structures of PHD{sub UHRF1} bound to histone H3 peptides, where the guanidinium group of unmodified R2 forms an extensive intermolecular hydrogen bond network, with methylation of H3R2, but not H3K4 or H3K9, disrupting complex formation. We have identified direct target genes of UHRF1 from microarraymore » and ChIP studies. Importantly, we show that UHRF1's ability to repress its direct target gene expression is dependent on PHD{sub UHRF1} binding to unmodified H3R2, thereby demonstrating the functional importance of this recognition event and supporting the potential for crosstalk between histone arginine methylation and UHRF1 function.« less

Germ cell tumors: Insights from the Drosophila ovary and the mouse testis.

PubMed

Salz, Helen K; Dawson, Emily P; Heaney, Jason D

2017-03-01

Ovarian and testicular germ cell tumors of young adults are thought to arise from defects in germ cell development, but the molecular mechanisms underlying malignant transformation are poorly understood. In this review, we focus on the biology of germ cell tumor formation in the Drosophila ovary and the mouse testis, for which evidence supports common underlying mechanisms, such as blocking initiation into the differentiation pathway, impaired lineage progression, and sexual identity instability. We then discuss how these concepts inform our understanding of the disease in humans. Mol. Reprod. Dev. 84: 200-211, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Ambarish Nag | NREL

Science.gov Websites

|Mathematical biology Education Ph.D., Computational Chemistry, University of Chicago M.S., Chemistry , University of Chicago M.S., (2-Year) Chemistry, Indian Institute of Technology, Kanpur, India B.S., Chemistry

Observation of Electronic Excitation Transfer Through Light Harvesting Complex II Using Two-Dimensional Electronic-Vibrational Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Nicholas H. C.; Gruenke, Natalie L.; Oliver, Thomas A. A.

Light-harvesting complex II (LHCII) serves a central role in light harvesting for oxygenic photosynthesis and is arguably the most important photosynthetic antenna complex. In this article, we present two-dimensional electronic–vibrational (2DEV) spectra of LHCII isolated from spinach, demonstrating the possibility of using this technique to track the transfer of electronic excitation energy between specific pigments within the complex. We assign the spectral bands via comparison with the 2DEV spectra of the isolated chromophores, chlorophyll a and b, and present evidence that excitation energy between the pigments of the complex are observed in these spectra. Lastly, we analyze the essential componentsmore » of the 2DEV spectra using singular value decomposition, which makes it possible to reveal the relaxation pathways within this complex.« less

Therapeutic Strategies against Cyclin E1-Amplified Ovarian Cancers

DTIC Science & Technology

2017-10-01

Ph.D. CONTRACTING ORGANIZATION: The Wistar Institute of Anatomy & Biology Philadelphia, PA 19104 REPORT DATE: October 2017 TYPE OF REPORT: Annual...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER The Wistar Institute of Anatomy & Biology 3601 Spruce Street Philadelphia, PA...ovarian cancers that address different aspects of CCNE1 biology . In the first aim, based on our preliminary data, we hypothesize that HSP90

Time-to-Credit Gender Inequities of First-Year PhD Students in the Biological Sciences

PubMed Central

Feldon, David F.; Peugh, James; Maher, Michelle A.; Roksa, Josipa; Tofel-Grehl, Colby

2017-01-01

Equitable gender representation is an important aspect of scientific workforce development to secure a sufficient number of individuals and a diversity of perspectives. Biology is the most gender equitable of all scientific fields by the marker of degree attainment, with 52.5% of PhDs awarded to women. However, equitable rates of degree completion do not translate into equitable attainment of faculty or postdoctoral positions, suggesting continued existence of gender inequalities. In a national cohort of 336 first-year PhD students in the biological sciences (i.e., microbiology, cellular biology, molecular biology, developmental biology, and genetics) from 53 research institutions, female participants logged significantly more research hours than males and were significantly more likely than males to attribute their work hours to the demands of their assigned projects over the course of the academic year. Despite this, males were 15% more likely to be listed as authors on published journal articles, indicating inequality in the ratio of time to credit. Given the cumulative advantage that accrues for students who publish early in their graduate careers and the central role that scholarly productivity plays in academic hiring decisions, these findings collectively point to a major potential source of persisting underrepresentation of women on university faculties in these fields. PMID:28130271

Grantee Spotlight: Nathan Ellis, Ph.D.

Cancer.gov

Dr. Nathan Ames Ellis, a CRCHD U01 grantee, uses comparative population-genetic analysis to shed new light on cancer susceptibility and the biological basis of colorectal cancer disparities in African Americans.

76 FR 80375 - National Cancer Institute; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... 20852. Contact Person: Shakeel Ahmad, Ph.D. Scientific Review Officer, Research Programs Review Branch..., Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology...

76 FR 26309 - National Cancer Institute; Notice Closed Meeting

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2011-05-06

... Person: Lalita D. Palekar, PhD, Scientific Review Officer, Special Review and Logistics Branch, Division..., Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology...

77 FR 4052 - National Cancer Institute; Notice of Closed Meeting

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2012-01-26

..., Ph.D., Scientific Review Officer, Resources and Training Review Branch, Division of Extramural....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93...

A Framework for Modeling and Simulation of the Artificial

DTIC Science & Technology

2012-01-01

y or n) >> y Name: petra Simple Aspects: face_shape/thin, nose/small, skintone/light, hair_color/black, hair_type/curly Integrated Aspects...Multiconference. Orlando, FL (2012) 23. Mittal, S., Risco- Martin , J.: Netcentric System of Systems Engineering with DEVS Unified Process. CRC Press (2012) 24...Mittal, S., Risco- Martin , J., Zeigler, B.: DEVS-based simulation web services for net-centric T&E. In: Proceedings of the 2007 summer computer

Naval Open Architecture Machinery Control Systems for Next Generation Integrated Power Systems

DTIC Science & Technology

2012-05-01

PORTABLE) OS / RTOS ADAPTATION MIDDLEWARE (FOR OS PORTABILITY) MACHINERY CONTROLLER FRAMEWORK MACHINERY CONTROL SYSTEM SERVICES POWER CONTROL SYSTEM...SERVICES SHIP SYSTEM SERVICES TTY 0 TTY N … OPERATING SYSTEM ( OS / RTOS ) COMPUTER HARDWARE UDP IP TCP RAW DEV 0 DEV N … POWER MANAGEMENT CONTROLLER...operating systems (DOS, Windows, Linux, OS /2, QNX, SCO Unix ...) COMPUTERS: ISA compatible motherboards, workstations and portables (Compaq, Dell

75 FR 21645 - National Cancer Institute; Notice of Closed Meeting

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2010-04-26

... F. Korczak, PhD, Scientific Review Officer, Resources and Training Review Branch, Division of... Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers...

76 FR 78013 - National Cancer Institute; Notice of Closed Meeting

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2011-12-15

... F. Korczak, Ph.D., Scientific Review Administrator, Resources and Training Review Branch, Division... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397...

75 FR 21644 - National Cancer Institute; Notice of Closed Meeting

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2010-04-26

... E Bird, PhD, Chief, Resources and Training Review Branch, Division of Extramural Activities..., Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398...

76 FR 80374 - National Cancer Institute; Notice of Closed Meeting

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2011-12-23

.... Contact Person: Ilda M. Mckenna, PhD, Scientific Review Officer, Research Training Review Branch, Division..., Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology...

76 FR 50234 - National Cancer Institute; Notice of Closed Meeting

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2011-08-12

...: Jeannette F. Korczak, PhD, Scientific Review Administrator, Resources and Training Review Branch, Division... and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397...

Dissertation Citations in Organismal Biology at Southern Illinois University at Carbondale: Implications for Collection Development

ERIC Educational Resources Information Center

Nabe, Jonathan; Imre, Andrea

2008-01-01

We report on a citation analysis of Ph.D. dissertations in plant biology and zoology at Southern Illinois University Carbondale, undertaken to test the common assumption that scientists favor current research to such an extent that journal backfiles can be de-emphasized in academic library collections. Results demonstrate otherwise. The study is…

From the Bench to the Clinic Part 1: Martin McIntosh, Ph.D., Introduces His Lab's Immunotherapy Research | Office of Cancer Genomics

Cancer.gov

The field of immunotherapy is rapidly advancing and genomics techniques are being incorporated to add a “precision” approach. OCG spoke with two CTD2 investigators from the Fred Hutchinson Cancer Research Center (FHCRC) about new advances in immunotherapy. For the first article of this two-part series, we interviewed Martin McIntosh, Ph.D., member of the Fred Hutchinson Translational Research program and previously Program Head in Computational Biology at FHCRC/University of Washington Comprehensive Cancer Center.

Monomeric CH3: A Small, Stable Antibody Domain with Therapeutic Promise | Poster

Cancer.gov

By Ashley DeVine, Staff Writer Antibody domains are emerging as promising biopharmaceuticals because of their relatively small size compared to full-sized antibodies, which are too large to effectively penetrate tumors and bind to sterically restricted therapeutic targets. In an article published in The Journal of Biological Chemistry, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, reported their design of a novel antibody domain, monomeric CH3 (mCH3).

Biological Treatment of Composition B Wastewaters. 2. Analysis of Performance of Holston Army Ammunition Plant Wastewater Treatment Facility, January 1985 through August 1986

DTIC Science & Technology

1988-08-18

CONTENTS (cont.) C. Daily Average Nitrate Nitrogen, Upper Neutralization Basin .................................. 44 D . Daily Average Temperature (°C...PLANr WASTEWATER TREATMENT FACILITY, JANUARY 1985 THROUGH AUGUST 1986 W. DICKINSON BURROWS, Ph.D., P.E. in- T C ELIZABetH T. PAULSONS D ROBERT P...CARNAHAN, Ph.D., P.E.:.EL E C-T E FEB 0 6 1990. D Prepared for U.S. ARMY TOXIC AND PAZARDOUS MATERIALS AGENCY ABERDEEN PROVING GROUND, D ) 21010-5401 by U S

76 FR 9354 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

...: Center for Scientific Review Special Emphasis Panel; Member Conflict: Cancer Biology and Therapy. Date... (Telephone Conference Call). Contact Person: Fouad A. El-Zaatari, PhD, Scientific Review Officer, Center for...

77 FR 24969 - National Cancer Institute; Notice of Closed Meeting

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2012-04-26

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76 FR 20693 - National Cancer Institute; Notice of Closed Meeting

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2011-04-13

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78 FR 18357 - National Cancer Institute; Notice of Closed Meeting

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2013-03-26

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75 FR 56548 - National Cancer Institute; Notice of Closed Meeting

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2010-09-16

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76 FR 14675 - National Cancer Institute; Notice of Closed Meeting

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2011-03-17

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78 FR 20119 - National Cancer Institute; Notice of Closed Meeting

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2013-04-03

.... Contact Person: Sergei Radaev, Ph.D., Scientific Review Officer, Resources and Training Review Branch... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397...

Primer and interviews: Molecular mechanisms of morphological evolution

PubMed Central

Kiefer, Julie C

2010-01-01

The beauty of the developing embryo, and the awe that it inspires, lure many scientists into the field of developmental biology. What compels cells to divide, migrate, and morph into a being with a complex body plan? Evolutionary developmental biologists hold similar fascinations, with dynamics that take place on a grander timescale. How do phenotypic traits diverge over evolutionary time? This primer illustrates how a deep understanding of the basic principles that underlie developmental biology have changed how scientists think about the evolution of body form. The primer culminates in a conversation with David Stern, PhD, and Michael Shapiro, PhD, who discuss current topics in morphological evolution, why the field should be of interest to classic developmental biologists, and what lies ahead. Developmental Dynamics 239:3497–3505, 2010. © 2010 Wiley-Liss, Inc. PMID:21069831

SB6.0: The 6th International meeting on Synthetic Biology, July 9-11, 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahl, Linda J.

The Synthetic Biology conference series (SBx.0) is the preeminent academic meeting in synthetic biology. Organized by the BioBricks Foundation, the SBx.0 conference series brings together leading researchers, students, industry executives, and policy makers from around the world to share, consider, debate, and plan efforts to make biology easier to engineer. Historically held every two years, the SBx.0 conferences are held in alternating locations in the United States, Europe, and Asia to encourage global participation and collaboration so that the ramifications of synthetic biology research and development are most likely to be safe ethical, and beneficial. On 9-11 July 2013, themore » 6th installment of the synthetic biology conference series (SB6.0) was held on the campus of Imperial College London (http://sb6.biobricks.org). The SB6.0 conference was attended by over 700 people, and many more were able to participate via video digital conference (http://sb6.biobricks.org/digital-conference/). Over the course of three days, the SB6.0 conference agenda included plenary sessions, workshops, and poster presentations covering topics ranging from the infrastructure needs arising when “Systematic Engineering Meets Biological Complexity” and design-led considerations for “Connecting People and Technologies” to discussions on “Engineering Biology for New Materials,” “Assessing Risk and Managing Biocontainment,” and “New Directions for Energy and Sustainability.” The $10,150 grant awarded by the U.S. Department of Energy (DE-SC0010233) to the BioBricks Foundation was used to provide partial reimbursement for the travel expenses of leading researchers from the United States to speak at the SB6.0 conference. A total of $9,450 was used to reimburse U.S. speakers for actual expenses related to the SB6.0 conference, including airfare (economy or coach only), ground transportation, hotel, and registration fees. In addition, $700 of the grant was used to offset direct administrative costs associated with selecting speakers (preparing announcements, evaluating abstract submissions) and handling travel arrangements. Leading U.S. researchers selected to speak at the SB6.0 conference included: Adam Arkin, Ph.D. Division Director of the Physical Biosciences Division at the Lawrence Berkeley National Laboratory and Professor in the Department of Bioengineering at UC Berkeley Jay Keasling, Ph.D. Professor in the Department of Bioengineering at Berkeley, Senior Faculty Scientist and Associate Laboratory Director of the Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute. Debra Mathews, Ph.D. Assistant Director for Science Programs for the Johns Hopkins Berman Institute of Bioethics, Assistant Professor in the Department of Pediatrics, and Affiliate Faculty in the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine. Richard Murray, Ph.D. Thomas E. and Doris Everhart Professor of Control & Dynamical Systems and Bioengineering at Caltech. Sarah Richardson, Ph.D. Distinguished Postdoctoral Fellow in Genomics at the Lawrence Berkeley National Laboratory and the Department of Energy Joint Genome Institute. and others (for a complete listing of speakers presenting at the SB6.0 conference see http://sb6.biobricks.org/speakers/) The SB6.0 conference was the largest synthetic biology conference to date, and highlights of the SB6.0 conference have been published in a special issue of ACS Synthetic Biology (http://pubs.acs.org/toc/asbcd6/3/3). The BioBricks Foundation appreciates the support of the U.S. Department of Energy in helping to make this most influential and important conference in the field of synthetic biology a success.« less

Tutorial for Thermophysics Universal Research Framework

DTIC Science & Technology

2017-07-30

DS1V are compared in Section 3.4.5. 3.4.2 Description of the Example Problem In a fluid, disturbance information is communicated within a medium at the...Universal Research Framework development (TURF-DEV) package on a case-by-case basis. Brief descriptions of the operations are provided in Tables 4.1 and...of additional experimental (E) and research (R) operations included in TURF-DEV. Module Operation Description DSMC SPDistDirectDSMCCellMergeOp (R

DEVS Unified Process for Web-Centric Development and Testing of System of Systems

DTIC Science & Technology

2008-05-20

gathering from the user. Further, methodologies have been developed to generate DEVS models from BPMN /BPEL-based and message-based requirement specifications...27] 3. BPMN /BPEL based system specifications: Business Process Modeling Notation ( BPMN ) [bpm] or Business Process Execution Language (BPEL) provide a...information is stored in .wsdl and .bpel files for BPEL but in proprietary format for BPMN . 4. DoDAF-based requirement specifications: Department of

[Research in the PhD Program led by János Fehér between 1993 and 2010 at the Biochemical Research Laboratory, 2nd Department of Medicine, Semmelweis University].

PubMed

Blázovics, Anna

2010-11-21

Author wish to express gratitude to late professor János Fehér for the invitation to participate in "Free Radical and Immunological References of Hepatology" PhD program in 1993 and for providing opportunity to establish a laboratory at the 2nd Department of Medicine, Semmelweis University. He established a joint medical and biological research that is continuing unbrokenly. In this research group, between 1993 and 2010, eleven Ph.D. students received their scientific degrees and two candidate dissertations were prepared. Three students are working in this very exciting field even today. Author would like to salute before János Fehér's remembrance by giving a list of results of topics under her leadership.

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

PubMed Central

Xie, Liang; Pi, Xinchun; Mishra, Ashutosh; Fong, Guohua; Peng, Junmin; Patterson, Cam

2012-01-01

The DNA damage response (DDR) is a complex regulatory network that is critical for maintaining genome integrity. Posttranslational modifications are widely used to ensure strict spatiotemporal control of signal flow, but how the DDR responds to environmental cues, such as changes in ambient oxygen tension, remains poorly understood. We found that an essential component of the ATR/CHK1 signaling pathway, the human homolog of the Caenorhabditis elegans biological clock protein CLK-2 (HCLK2), associated with and was hydroxylated by prolyl hydroxylase domain protein 3 (PHD3). HCLK2 hydroxylation was necessary for its interaction with ATR and the subsequent activation of ATR/CHK1/p53. Inhibiting PHD3, either with the pan-hydroxylase inhibitor dimethyloxaloylglycine (DMOG) or through hypoxia, prevented activation of the ATR/CHK1/p53 pathway and decreased apoptosis induced by DNA damage. Consistent with these observations, we found that mice lacking PHD3 were resistant to the effects of ionizing radiation and had decreased thymic apoptosis, a biomarker of genomic integrity. Our identification of HCLK2 as a substrate of PHD3 reveals the mechanism through which hypoxia inhibits the DDR, suggesting hydroxylation of HCLK2 is a potential therapeutic target for regulating the ATR/CHK1/p53 pathway. PMID:22797300

A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis.

PubMed

Zhang, Lin; Huang, Qin; Lou, Jiatao; Zou, Liangjian; Wang, Yiguo; Zhang, Peng; Yang, Guang; Zhang, Junyi; Yu, Lan; Yan, Dai; Zhang, Chenyi; Qiao, Jing; Wang, Shuting; Wang, Sai; Xu, Yongdong; Ji, Hongbin; Chen, Zhengjun; Zhang, Zhe

2017-03-21

The plant homeodomain (PHD) finger-containing proteins have been implicated in many human diseases including cancer. In this study, we found that PHF14, a newly identified PHD finger protein, is highly expressed in lung cancer. The high expression level of PHF14 was associated with adenocarcinoma and poor survival in lung cancer patients. Knocking down PHF14 suppressed cancer cell growth and carcinogenesis, while over-expressing PHF14 promoted cell proliferation. During cell division, PHF14 directly bound to and co-localized with KIF4A (a nuclear motor protein involved in lung carcinogenesis) to form a functional complex. Similarly to the effect of KIF4A depletion, silencing PHF14 in several cell lines caused cell mitotic defects, prolonged M phase, and inhibited cell proliferation. What's more, these two proteins had a synergistic effect on cell proliferation and were significantly co-overexpressed in lung cancer tissues. Our data provide new insights into the biological significance of PHD finger proteins and imply that PHF14 may be a potential biomarker for lung cancer.

76 FR 25308 - Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-04

...-XA165 Marine Mammals AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Jennifer Burns, Ph.D., University of Alaska Anchorage, Biology Department, 3101 Science Circle, Anchorage, AK, has been issued a permit to conduct [[Page 25309

Wenyi Wang, Statistical Bioinformatics Expert, Visits DCEG

Cancer.gov

In March 2018, Wenyi Wang, Ph.D., Associate Professor in the Department of Bioinformatics and Computational Biology at the University of Texas MD Anderson Cancer Center, visited DCEG to give a seminar and meet with staff.

Time-to-Credit Gender Inequities of First-Year PhD Students in the Biological Sciences

ERIC Educational Resources Information Center

Feldon, David F.; Peugh, James; Maher, Michelle A.; Roksa, Josipa; Tofel-Grehl, Colby

2017-01-01

Equitable gender representation is an important aspect of scientific workforce development to secure a sufficient number of individuals and a diversity of perspectives. Biology is the most gender equitable of all scientific fields by the marker of degree attainment, with 52.5% of PhDs awarded to women. However, equitable rates of degree completion…

CCR researchers provide insight into pathway that initiates a common type of skin cancer | Center for Cancer Research

Cancer.gov

Since studies in mice have elucidated much about tumor biology, Stuart Yuspa, M.D., and Christophe Cataisson, Ph.D., of CCR’s Laboratory of Cancer Biology and Genetics, and their colleagues decided to study mice that overexpress hepatocyte growth factor (HGF) to understand the role the pathway plays in squamous cell cancer (SCC).

Graduate Training at the Interface of Computational and Experimental Biology: An Outcome Report from a Partnership of Volunteers between a University and a National Laboratory

PubMed Central

von Arnim, Albrecht G.; Missra, Anamika

2017-01-01

Leading voices in the biological sciences have called for a transformation in graduate education leading to the PhD degree. One area commonly singled out for growth and innovation is cross-training in computational science. In 1998, the University of Tennessee (UT) founded an intercollegiate graduate program called the UT-ORNL Graduate School of Genome Science and Technology in partnership with the nearby Oak Ridge National Laboratory. Here, we report outcome data that attest to the program’s effectiveness in graduating computationally enabled biologists for diverse careers. Among 77 PhD graduates since 2003, the majority came with traditional degrees in the biological sciences, yet two-thirds moved into computational or hybrid (computational–experimental) positions. We describe the curriculum of the program and how it has changed. We also summarize how the program seeks to establish cohesion between computational and experimental biologists. This type of program can respond flexibly and dynamically to unmet training needs. In conclusion, this study from a flagship, state-supported university may serve as a reference point for creating a stable, degree-granting, interdepartmental graduate program in computational biology and allied areas. PMID:29167223

Something going on in Milan: a review of the 4th International PhD Student Cancer Conference.

PubMed

Segré, C

2010-01-01

The 4th International PhD Student Cancer Conference was held at the IFOM-IEO-Campus in Milan from 19-21 May 2010 http://www.semm.it/events_researchPast.phpThe Conference covered many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees presented their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe.THE CORE PARTICIPANTING INSTITUTES INCLUDED: European School of Molecular Medicine (SEMM)-IFOM-IEO Campus, MilanBeatson Institute for Cancer Research (BICR), GlasgowCambridge Research Institute (CRI), Cambridge, UKMRC Gray Institute of Radiation Biology (GIROB), OxfordLondon Research Institute (LRI), LondonPaterson Institute for Cancer Research (PICR), ManchesterThe Netherlands Cancer Institute (NKI), Amsterdam'You organizers have crushed all my prejudices towards Italians. Congratulations, I enjoyed the conference immensely!' Even if it might have sounded like rudeness for sure this was supposed to be a genuine compliment (at least, that's how we took it), also considering that it was told by a guy who himself was the fusion of two usually antithetical concepts: fashion style and English nationality.The year 2010 has marked an important event for Italian research in the international scientific panorama: the European School of Molecular Medicine (SEMM) had the honour to host the 4th International PhD Student Cancer Conference, which was held from 19-21 May 2010 at the IFOM-IEO-Campus (http://www.semm.it/events_researchPast.php) in Milan.The conference was attended by more than one hundred students, coming from a selection of cutting edge European institutes devoted to cancer research. The rationale behind it is the promotion of cooperation among young scientists across Europe to debate about science and to exchange ideas and experiences. But that is not all, it is also designed for PhD students to get in touch with other prestigious research centres and to create connections for future post docs or job experiences. And last but not least, it is a golden chance for penniless PhD students to spend a couple of extra days visiting a foreign country (this motivation will of course never be voiced to supervisors).The network of participating institutes has a three-nation core, made up of the Netherlands Cancer Institute, the Italian European School of Molecular Medicine (SEMM) and five UK Cancer Research Institutes (The London Research Institute, The Cambridge Research Institute, The Beatson Institute for Cancer Research in Glasgow, The Patterson Institute for Cancer Research in Manchester and the MRC Gray Institute for Radiation Oncology and Biology in Oxford).The conference is hosted and organised every year by one of the core institutes; the first was in Cambridge in 2007, Amsterdam in 2008 and London in 2009, this year was the turn of Milan.In addition to the core institutes, PhD students from several other high-profile institutes are invited to attend the conference. This year participants applied from the Spanish National Cancer Centre (CNIO, Madrid), the German Cancer Research Centre (DKFZ, Heidelberg), the European Molecular Biology Labs (EMBL, Heidelberg) and the San Raffaele Institute (HSR, Milan). Moreover four 'special guests' from the National Centre for Biological Sciences of Bangalore (India) attended the conference in Milan. This represents a first step in widening the horizons beyond Europe into a global worldwide network of talented PhD students in life sciences.The conference spread over two and a half days (Wednesday 19th to Friday 21st May) and touched on a broad spectrum of topics: from basic biology to development, from cancer therapies to modelling and top-down new generation global approaches. The final selection of presentations has been a tough task for us organisers (Chiara Segré, Federica Castellucci, Francesca Milanesi, Gianluca Varetti and Gian Maria Sarra Ferraris), due to the high scientific level of the abstracts submitted. In the end, 26 top students were chosen to give a 15-min oral presentation in one of eight sessions: Development & Differentiation, Cell Migration, Immunology & Cancer, Modelling & Large Scale approaches, Genome Instability, Signal Transduction, Cancer Genetics & Drug Resistance, Stem Cells in Biology and Cancer.The scientific programme was further enriched by two scientific special sessions, held by Professor Pier Paolo di Fiore and Dr Giuseppe Testa, Principal Investigators at the IFOM-IEO-Campus and by a bioethical round table on human embryonic stem cell research moderated by Silvia Camporesi, a senior PhD student in the SEMM PhD Programme 'Foundation of Life Science and their Bioethical Consequences'.ON TOP OF EVERYTHING, WE HAD THE PLEASURE OF INVITING, AS KEYNOTE SPEAKERS, TWO LEADING EUROPEAN SCIENTISTS IN THE FIELDS OF CANCER INVASION AND BIOLOGY OF STEM CELLS, RESPECTIVELY: Dr Peter Friedl from The Nijmegen Centre for Molecular Life (The Netherlands) and Professor Andreas Trumpp from The Heidelberg Institute for Stem Cell Technology and Experimental Medicine (Heidelberg).All the student talks have distinguished themselves for the impressive quality of the science; an encouraging evidence of the high profile level of research carried out in Europe. It would be beyond the purposes of this report to summarise all 26 talks, which touched many different and specific topics. For further information, the Conference Abstract book with all the scientific content is available on the conference Web site (http://www.semm.it/events_researchPast.php). In what follows, the special sessions and the keynote lectures will be discussed in detail.

Metabolic Regulation of Caspase 2 in Breast Cancer

DTIC Science & Technology

2011-04-01

S. The apoptosome: physiological, developmental, and pathological modes of regulation. Dev Cell 10, 549-61 ( 2006 ). 3. Baliga, B.C., Read, S.H...Mol Biol Cell 17, 2150-7 ( 2006 ). 9. Bergeron, L. et al. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 12, 1304-14 (1998...Warburg, O. On the origin of cancer cells. Science 123, 309-14 (1956). 17. Lassus, P., Opitz- Araya , X. & Lazebnik, Y. Requirement for caspase-2 in

Short hairpin RNA interference therapy for ischemic heart disease.

PubMed

Huang, Mei; Chan, Denise A; Jia, Fangjun; Xie, Xiaoyan; Li, Zongjin; Hoyt, Grant; Robbins, Robert C; Chen, Xiaoyuan; Giaccia, Amato J; Wu, Joseph C

2008-09-30

During hypoxia, upregulation of hypoxia inducible factor-1 alpha transcriptional factor can activate several downstream angiogenic genes. However, hypoxia inducible factor-1 alpha is naturally degraded by prolyl hydroxylase-2 (PHD2) protein. Here we hypothesize that short hairpin RNA (shRNA) interference therapy targeting PHD2 can be used for treatment of myocardial ischemia and this process can be followed noninvasively by molecular imaging. PHD2 was cloned from mouse embryonic stem cells by comparing the homolog gene in human and rat. The best candidate shRNA sequence for inhibiting PHD2 was inserted into the pSuper vector driven by the H1 promoter followed by a separate hypoxia response element-incorporated promoter driving a firefly luciferase reporter gene. This construct was used to transfect mouse C2C12 myoblast cell line for in vitro confirmation. Compared with the control short hairpin scramble (shScramble) as control, inhibition of PHD2 increased levels of hypoxia inducible factor-1 alpha protein and several downstream angiogenic genes by >30% (P<0.01). Afterward, shRNA targeting PHD2 (shPHD2) plasmid was injected intramyocardially following ligation of left anterior descending artery in mice. Animals were randomized into shPHD2 experimental group (n=25) versus shScramble control group (n=20). Bioluminescence imaging detected plasmid-mediated transgene expression for 4 to 5 weeks. Echocardiography showed the shPHD2 group had improved fractional shortening compared with the shScramble group at Week 4 (33.7%+/-1.9% versus 28.4%+/-2.8%; P<0.05). Postmortem analysis showed increased presence of small capillaries and venules in the infarcted zones by CD31 staining. Finally, Western blot analysis of explanted hearts also confirmed that animals treated with shPHD2 had significantly higher levels of hypoxia inducible factor-1 alpha protein. This is the first study to image the biological role of shRNA therapy for improving cardiac function. Inhibition of PHD2 by shRNA led to significant improvement in angiogenesis and contractility by in vitro and in vivo experiments. With further validation, the combination of shRNA therapy and molecular imaging can be used to track novel cardiovascular gene therapy applications in the future.

Short hairpin RNA interference therapy for ischemic heart disease

PubMed Central

Huang, Mei; Chan, Denise; Jia, Fangjun; Xie, Xiaoyan; Li, Zongjin; Hoyt, Grant; Robbins, Robert C.; Chen, Xiaoyuan; Giaccia, Amato; Wu, Joseph C.

2013-01-01

Background During hypoxia, upregulation of hypoxia inducible factor-1 alpha (HIF-1α) transcriptional factor can activate several downstream angiogenic genes. However, HIF-1α is naturally degraded by prolyl hydroxylase-2 (PHD2) protein. Here we hypothesize that short hairpin RNA (shRNA) interference therapy targeting PHD2 can be used for treatment of myocardial ischemia and this process can be followed noninvasively by molecular imaging. Methods and Results PHD2 was cloned from mouse embryonic stem (ES) cells by comparing the homolog gene in human and rat. The best candidate shRNA sequence for inhibiting PHD2 was inserted into the pSuper vector driven by the H1 promoter, followed by a separate hypoxia response element (HRE)-incorporated promoter driving a firefly luciferase (Fluc) reporter gene. This construct was used to transfect mouse C2C12 myoblast cell line for in vitro confirmation. Compared to the control short hairpin scramble (shScramble) as control, inhibition of PHD2 increased levels of HIF-1α protein and several downstream angiogenic genes by >30% (P<0.01). Afterwards, shRNA targeting PHD2 (shPHD2) plasmid was injected intramyocardially following ligation of left anterior descending (LAD) artery in mice. Animals were randomized into shPHD2 group (n=20) versus shScramble sequence as control (n=20). Bioluminescence imaging detected transgene expression for 4–5 weeks. Echocardiographic study showed the shPHD2 group had improved fractional shortening compared with the shScramble group at week 4 (33.7%±1.9% vs. 28.4%±2.8%; P<0.05). Postmortem analysis showed increased presence of small capillaries and venules in the infarcted zones by CD31 staining. Finally, Western blot anlaysis of explanted hearts also confirm that animals treated with shPHD2 had significantly higher levels of HIF-1α protein. Conclusions This is the first study to image the biological role of shRNA therapy for improving cardiac function. Inhibition of PHD2 by shRNA led to significant improvement in angiogenesis and contractility by in vitro and in vivo experiments. With further validation, the combination of shRNA therapy and molecular imaging can be used to track novel cardiovascular gene therapy applications in the future. PMID:18824759

Catalog of Completed Studies, US Army Health Care Studies and Clinical Investigation Activity.

DTIC Science & Technology

1984-12-10

EDUCATION: B.S., 1967, University of Texas at Austin (Chemistry) Ph.D., 1972, University of Southern California (Molecular Biology ) MEMBERSHIP...WALTER A. BRUSCH RANK: COL, Dental Corps Chief: Dental Studies EDUCATION: B.S., 1957, Xavier University ( Biology ) D.D.S., 1961, St. Louis University M.S.D... Biology , New York University D.M.D., 1971, University of Pennsylvania M.A., 1979, Education, George Washington University M.S.P.H., 1982, University of

Meet EPA Chemist Mark Strynar, Ph.D.

EPA Pesticide Factsheets

Dr. Mark Strynar is a physical scientist in EPA's Office of Research and Development. His research interests include developing methods to measure and analyze the movement of PFCs and other xenobiotic compounds in biological and environmental media

76 FR 59708 - National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... and Alcoholism Special Emphasis Panel, Systems Biology of HIV/AIDS and Substance Use--RFA DA12-009..., PhD, Chief, Extramural Project Review Branch, EPRB, NIAAA, National Institutes of Health, 5365...

Investigator profile. An interview with Salvador Contreras Balderas, Ph.D. Interview by Vicki Glaser.

PubMed

Contreras Balderas, Salvador

2006-01-01

Dr. Contreras Balderas is Professor Emeritus in the Department of Biology at Universidad Autonoma de Nuevo Leon (Monterrey, Mexico). He received a Master's degree and Ph.D. in Biological Sciences from Tulane University (New Orleans, LA) and wrote his dissertation on Ichthyology. He was awarded the President's Excellence Award of the American Fisheries Society. Dr. Contreras Balderas is Founder, President, and Honorary Member of the Mexican Society of Zoology, the Ichthyological Society of Mexico, and the Desert Fishes Council, is an ex-officio member of the Coalition for the Sustainable Development of the Rio Grande/Rio Bravo, U.S. & Mexico, and is a member of the U.S. Fish and Wildlife's Rio Grande Fishes Recovery Team. Dr. Contreras Balderas's areas of expertise include fish faunas, fishes at risk, exotic species, aquatic restoration, environmental impacts as detected by fishes, integral conservation, integral basin/ecosystem management, and ecological evaluation of integrity in basins.

Careers in cancer prevention research - Reflections from a large outcomes evaluation study

Cancer.gov

Jessica Faupel-Badger, Ph.D., is director of the NIGMS Postdoctoral Research Associate (PRAT) Program and manages Institutional Research and Academic Career Development Awards (IRACDA) grants in the Division of Training, Workforce Development, and Diversity. Before coming to NIGMS, Faupel-Badger served as a senior biomedical scientist and deputy director of the Cancer Prevention Fellowship Program at the National Cancer Institute (NCI). Prior to that, she was a health science policy analyst at National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Faupel-Badger earned her B.S. in biology from Gettysburg College, a Ph.D. in tumor biology from the Mayo Clinic College of Medicine and an M.P.H. in epidemiology and biostatistics from George Washington University. She conducted postdoctoral research at NCI, where she currently serves as an adjunct investigator in the Division of Cancer Epidemiology and Genetics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jurisson, Silvia S.; Lever, Susan Z.; Robertson, J. David

This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers thatmore » will be radiolabeled with 18F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.« less

Assessments and Viewpoints on the Biological and Human Health Effects of Extremely Low Frequency (ELF) Electromagnetic Fields. Compilation of Commissioned Papers for the ELF Literature Review Project.

DTIC Science & Technology

1985-05-01

Environ. Biophys. 20:53-65. 1983. Electric field effects on bacteria and yeast cells . Radiat. Environ. Biophys. 22 :149-162. Husing, J. 0., F. Strauss, and...Jr., Ph.D. 141 A Review of Cell Effects Induced by Exposure of Extremely Low 155 Frequency Electromagnetic Fields - Eugene M. Goodman, Ph.D. and Ben...and E. M. Goodman. 1983. Cell surface effects of 60 Hz electromagnetic fields. Radiat. Res. 94:217-220. artucci, G. I., P. C. Gailey, and R. A. Tell

Dissertations Initiative for the Advancement of Limnology and Oceanography (DIALOG)

NASA Technical Reports Server (NTRS)

1994-01-01

The DIALOG Program was founded by the American Society of Limnology and Oceanography (ASLO), in order to reduce the historical, institutional and philosophical barriers that limit the exchange of information between limnologists and oceanographers, and to foster interdisciplinary and inter-institutional research. This was achieved by targeting a recent cohort of Ph.D. recipients whose work included a biological component of limnology or oceanography. The program included: (1) publication of the submitted Ph.D. dissertation abstracts; (2) a symposium to facilitate exchange across institutions and disciplines; and (3) establishment of a centralized data base for applicant characterization and tracking.

DDN (Defense Data Network) Protocol Handbook. Volume 3. Supplement

DTIC Science & Technology

1985-12-01

the physical configuration which results from this arrangement, Michael Padlipsky has described this as the " milking machine" approach to computer...NEIRJS-3 74 NETRJS-4 75 77 79 FINGER 81 HOSTS2-NS 83 MIT-ML-DEV 85 MIT-ML-DEV 87 89 SU-MIT-TG 91 MIT-DOV 93 DCP 95 SUPDUP 97 SWIFT- RVF ...PUP QUOTE RDP RJE RLP RTELNET RVD SAT-EXPAK SAT-MON SFTT? SMTP ST SU-MIT-TG SUNRPC SUPDUP SUR-MEAS SWIFT- RVF TACACS-DS TACNEWS

IEEE Std 730 Software Quality Assurance: Supporting CMMI-DEV v1.3, Product and Process Quality Assurance

DTIC Science & Technology

2011-05-27

frameworks 4 CMMI-DEV IEEE / ISO / IEC 15288 / 12207 Quality Assurance ©2011 Walz IEEE Life Cycle Processes & Artifacts • Systems Life Cycle Processes...TAG to ISO TC 176 Quality Management • Quality: ASQ, work experience • Software: three books, consulting, work experience • Systems: Telecom & DoD...and IEEE 730 SQA need to align. The P730 IEEE standards working group has expanded the scope of the SQA process standard to align with IS 12207

Genetic and Molecular Analysis of the Mechanisms by which TSC Regulates Neuronal Differentiation

DTIC Science & Technology

2009-03-01

2004 Programmed autophagy in the Drosophila fat body is in- duced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7: 179–192. Sarbassov...embryonic Drosophila CNS. Mech. Dev. 64: 137–151. Scott, R. C., O. Schuldiner and T. P. Neufeld, 2004 Role and reg- ulation of starvation-induced autophagy ...in The Development of Drosophila melanogaster , edited by M. Bates and A. Martinez-Arias. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

Proceedings of the 2017 annual meeting of the Fetal Alcohol Spectrum Disorders study group.

PubMed

Wozniak, Jeffrey R; Klintsova, Anna Y; Hamilton, Derek A; Mooney, Sandra M

2018-06-01

The 2017 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was titled "Prenatal alcohol exposure in the context of multiple factors affecting brain development." The theme was reflected in the interactions between members of the Teratology Society and the FASDSG this year. The first keynote speaker, Elaine Faustman, Ph.D., was a liaison between the societies and spoke about systems biology and the multiple genetic and environmental influences on development. The second keynote speaker, Rebecca Knickmeyer, Ph.D., discussed population neuroscience and multiple influences on brain development. The conference presented updates from three government agencies and short presentations by junior and senior investigators showcasing late-breaking FASD research. The conference was capped by Dr. John Hannigan, Ph.D., the recipient of the 2017 Henry Rosett award for career-long contributions to the field. Copyright © 2017 Elsevier Inc. All rights reserved.

Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus

DTIC Science & Technology

2007-10-01

Crimean Congo Hemorrhagic Fever Virus PRINCIPAL INVESTIGATOR: Adolfo García-Sastre, Ph.D. CONTRACTING...Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus 5b. GRANT NUMBER W81XWH-04-1-0876 5c. PROGRAM ELEMENT...localization and antigenic characterization of Crimean - Congo hemorrhagic fever virus glycoproteins. J.Virol. 79: 6152-61. Ahmed, A., McFalls,

77 FR 58854 - Office of the Director, National Institutes of Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... current understanding of the basic biology of the genital tract for HIV prevention. An update will be... Level, Suite T-500, Rockville, MD 20852. Contact Person: Robert Eisinger, Ph.D., Executive Secretary...

Friends, friendlessness, and the social consequences of gaining a theory of mind.

PubMed

Fink, Elian; Begeer, Sander; Peterson, Candida C; Slaughter, Virginia; de Rosnay, Marc

2015-03-01

Fink, Begeer, Peterson, Slaughter, and de Rosnay (2014) conducted a prospective longitudinal study showing that theory-of-mind (ToM) development at school entry (mean age 5.61 years) significantly predicted friendlessness both concurrently and 2 years later. Friendlessness (defined as lacking any friendship that is mutually reciprocated) is conceptually and empirically distinct from group popularity and independently predicts adverse mental health outcomes throughout life. Here, we respond to the thoughtful commentaries by Wellman (Brit. J. Dev. Psychol, 2015; 33, 24-26), Mizokawa and Koyasu (Brit. J. Dev. Psychol, 2015; 33, 21-23), and Lerner and Lillard (Brit. J. Dev. Psychol, 2015; 33, 18-20) with a focus on three key issues, namely (a) the definition and measurement of friendship, (b) the measurement of advanced ToM development beyond the preschool years, and (c) the exciting future potential for ToM-based training and intervention studies to combat chronic friendlessness. © 2015 The British Psychological Society.

Methods of Academic Course Planning for Cancer Biology PhD Students to Enhance Knowledge of Clinical Oncology.

PubMed

Mattes, Malcolm D; Swart, Elizabeth; Markwell, Steven M; Wen, Sijin; Vona-Davis, Linda C

2017-09-15

Little is known about how clinical oncology concepts are taught to PhD students or the most effective methods of doing so. In this study, electronic surveys were sent to faculty and students at PhD training programs, assessing their institution's methods of clinical oncology education and their perspective on optimal approaches to clinical oncology education. Only 40.0% of students reported any clinical oncology component to their institution's training, and only 26.5% had a clinician on their graduate advisory committee. Forty-three percent of students believed that they had a good understanding for translating basic science research into clinical practice, and 77.2% of all participants believed dual degree MD/PhD students were superior to PhD students in this regard. Lectures on clinical oncology research topics were the most valuable type of experience for all participants and were also the most common type of experience utilized. Working with a clinician to develop a clinical trial with correlative endpoints was also highly valued, but was only utilized by approximately 10% of programs. Faculty rated the value of nearly all types of clinical oncology exposure significantly lower than did students. Inclusion of the approaches identified in this study is likely to enhance PhD training in oncology-related disciplines. Cancer Res; 77(18); 4741-4. ©2017 AACR . ©2017 American Association for Cancer Research.

The Ph.D. Process - A Student's Guide to Graduate School in the Sciences

NASA Astrophysics Data System (ADS)

Bloom, Dale F.; Karp, Jonathan D.; Cohen, Nicholas

1999-02-01

The Ph.D. Process offers the essential guidance that students in the biological and physical sciences need to get the most out of their years in graduate school. Drawing upon the insights of numerous current and former graduate students, this book presents a rich portrayal of the intellectual and emotional challenges inherent in becoming a scientist, and offers the informed, practical advice a "best friend" would give about each stage of the graduate school experience. What are the best strategies for applying to a graduate program? How are classes conducted? How should I choose an advisor and a research project? What steps can I take now to make myself more "employable" when I get my degree? What goes on at the oral defense? Through a balanced, thorough examination of issues ranging from lab etiquette to stress management, the authors--each a Ph.D. in the sciences--provide the vital information that will allow students to make informed decisions all along the way to the degree. Headlined sections within each chapter make it fast and easy to look up any subject, while dozens of quotes describing personal experiences in graduate programs from people in diverse scientific fields contribute invaluable real-life expertise. Special attention is also given to the needs of international students.Read in advance, this book prepares students for each step of the graduate school experience that awaits them. Read during the course of a graduate education, it serves as a handy reference covering virtually all major issues and decisions a doctoral candidate is likely to face. The Ph.D. Process is the one book every graduate student in the biological and physical sciences can use to stay a step ahead, from application all the way through graduation.

Outcomes and Processes in the Meyerhoff Scholars Program: STEM PhD Completion, Sense of Community, Perceived Program Benefit, Science Identity, and Research Self-Efficacy.

PubMed

Maton, Kenneth I; Beason, Tiffany S; Godsay, Surbhi; Sto Domingo, Mariano R; Bailey, TaShara C; Sun, Shuyan; Hrabowski, Freeman A

2016-01-01

Previous research has shown that the Meyerhoff Scholars Program at the University of Maryland, Baltimore County, is an effective intervention for high-achieving underrepresented minority (URM) students; African-American Meyerhoff students are significantly more likely to enter science, technology, engineering, and mathematics (STEM) PhD programs than comparison students. The first of two studies in this report extends the prior research by examining levels of PhD completion for Meyerhoff (N = 479) versus comparison sample (N = 249) students among the first 16 cohorts. Entering African-American Meyerhoff students were 4.8 times more likely to complete STEM PhDs than comparison sample students. To enhance understanding of potential mechanisms of influence, the second study used data from the 22nd (Fall 2010) to 25th (Fall 2013) cohorts (N = 109) to test the hypothesis that perceived program benefit at the end of freshman year would mediate the relationship between sense of community at the end of Summer Bridge and science identity and research self-efficacy at the end of sophomore year. Study 2 results indicated that perceived program benefit fully mediated the relationship between sense of community and both criterion measures. The findings underscore the potential of comprehensive STEM intervention programs to enhance PhD completion, and suggest mechanisms of influence. © 2016 K. I. Maton et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Scientific Growth and Identity Development during a Postbaccalaureate Program: Results from a Multisite Qualitative Study.

PubMed

Remich, Robin; Naffziger-Hirsch, Michelle E; Gazley, J Lynn; McGee, Richard

2016-01-01

This report builds upon our previous study, which described five patterns of why college graduates join National Institutes of Health (NIH)-funded diversity-focused Postbaccalaureate Research Education Programs (PREP). A 2015 report from the NIH showed that a high fraction of PREP participants matriculate into PhD and MD/PhD programs. This current study reveals how participants change during PREP, the program elements that facilitate change, and how identity as a graduate student and future scientist develops. Data come from in-depth interviews done at the beginning and end of PREP with 48 individuals from seven PREP programs. Results reveal three domains of development: academics, research, and presentation of oneself; each domain contains a developmental continuum. Key attributes of PREP enabling development include opportunities to attend graduate-level classes and seminars; time to practice reading literature; extended lab time with one's own project; high and explicit expectations from mentors; and multiple opportunities to talk about science and improve communication skills. PREP enabled participants to develop their identities as graduate students and to anticipate being seen by others as highly prepared for PhD training. After PREP, 85% (n = 41) started the PhD or MD/PhD, making PREP an intervention approach with great potential to broaden participation in biomedical PhD programs. © 2016 R. Remich et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report.

PubMed

Gnekow, Astrid K; Walker, David A; Kandels, Daniela; Picton, Susan; Giorgio Perilongo; Grill, Jacques; Stokland, Tore; Sandstrom, Per Eric; Warmuth-Metz, Monika; Pietsch, Torsten; Giangaspero, Felice; Schmidt, René; Faldum, Andreas; Kilmartin, Denise; De Paoli, Angela; De Salvo, Gian Luca

2017-08-01

The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection. Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology-Low Grade Glioma (SIOP LGG) Committee launched a randomised trial involving 118 institutions and 11 countries to investigate the addition of etoposide (100 mg/m 2 , days 1, 2 & 3) to a four-course induction of vincristine (1.5 mg/m 2  × 10 wkly) and carboplatin (550 mg/m 2 q 3 weekly) as part of 18-month continuing treatment programme. Patients were recruited after imaging diagnosis, resection or biopsy with progressive disease/symptoms. Some 497 newly diagnosed patients (M/F 231/266; median age 4.26 years (interquartile range (IQR) 2.02-7.06)) were randomised to receive vincristine carboplatin (VC) (n = 249) or VC plus etoposide (VCE) during induction (n = 248), stratified by age and tumour site. No differences between the two arms were found in term of survival and radiological response. Response and non-progression rates at 24 weeks for VC and VCE, were 46% versus 41%, and 93% versus 91% respectively; 5-year Progression-Free Survival (PFS) and Overall Survival (OS) were 46% (StDev 3.5) versus 45% (StDev 3.5) and 89% (StDev 2.1) versus 89% (StDev 2.1) respectively. Age and diencephalic syndrome are adverse clinical risk factors for PFS and OS. 5-year OS for patients in early progression at week 24 were 46% (StDev 13.8) and 49% (StDev 16.5) in the two arms, respectively. The addition of etoposide to VC did not improve PFS or OS. High non-progression rates at 24 weeks justify retaining VC as standard first-line therapy. Infants with diencephalic syndrome and early progression need new treatments to be tested. Future trials should use neurological/visual and toxicity outcomes and be designed to discriminate between the impact on disease outcomes of 'duration of therapy' and 'age at stopping therapy'. Copyright © 2017. Published by Elsevier Ltd.

Special Spotlight: Levi A. Garraway, M.D., Ph.D.

Cancer.gov

Dr. Levi A. Garraway, a former CRCHD CURE trainee, received the prestigious Jane Cooke Wright Lectureship Award at the 2014 meeting of the American Association for Cancer Research and presented "The Cancer Genome in Biology, Therapy, and Drug Resistance.”

76 FR 4091 - Marine Mammals; File No. 15510

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA165 Marine Mammals; File No. 15510 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Jennifer Burns, Ph.D., University of Alaska Anchorage, Biology Department, 3101 Science Circle, Anchorage...

77 FR 267 - Marine Mammals; File No. 16621

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA915 Marine Mammals; File No. 16621 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Alejandro Acevedo- Guti[eacute]rrez, Ph.D., Biology Department, Western Washington University, Bellingham...

Partial Characterization of a Novel Amphibian Hemoglobin as a Model for Graduate Student Investigation on Peptide Chemistry, Mass Spectrometry, and Atomic Force Microscopy

ERIC Educational Resources Information Center

Bemquerer, Marcelo P.; Macedo, Jessica K. A.; Ribeiro, Ana Carolina J.; Carvalho, Andrea C.; Silva, Debora O. C.; Braz, Juliana M.; Medeiros, Kelliane A.; Sallet, Lunalva A. P.; Campos, Pollyanna F.; Prates, Maura V.; Silva, Luciano P.

2012-01-01

Graduate students in chemistry, and in biological and biomedical fields must learn the fundamentals and practices of peptide and protein chemistry as early as possible. A project-oriented approach was conducted by first-year M.Sc and Ph.D students in biological sciences. A blind glass slide containing a cellular smear and an aqueous cellular…

Graduate Training at the Interface of Computational and Experimental Biology: An Outcome Report from a Partnership of Volunteers between a University and a National Laboratory

ERIC Educational Resources Information Center

von Arnim, Albrecht G.; Missra, Anamika

2017-01-01

Leading voices in the biological sciences have called for a transformation in graduate education leading to the PhD degree. One area commonly singled out for growth and innovation is cross-training in computational science. In 1998, the University of Tennessee (UT) founded an intercollegiate graduate program called the UT-ORNL Graduate School of…

Installation Restoration Program. Phase 1: Records Search, Beale AFB, California

DTIC Science & Technology

1984-04-25

following reasons: (1) to provide the continued protaction of human health, welfare, and the environment; (2) to insure that the migration c:-. potential...Education B.S. in Biology (magna cum laude), 1975, Stetson University, Deland, Florida Ph.D. in Ecology, 1982, State University of New York, Stony Brook...ecology, entomology, plant ecology, population bio- logy, genetics, and general biology . Developed and coordinated laboratory and field exercises

Supporting Data for FY 1990/1991 Biennial Budget: Budget Estimates Descriptive Summaries Submitted to Congress January 1989, Research, Development, Test & Evaluation, Navy

DTIC Science & Technology

1989-01-01

necessitate de -emphasizing network interface demonstrations in favor of real-time network interface technologies and slip ICEX demonstration of...Aperture Radar target classi- fication and Fault Diagnosis issues. o Demonstrate a complete, transportable , fully functional software engineering...BLK 3 MS 3B 109D MS 3A Blk 3 MS 2 TASM Milestones MS 3A 109D IOC Flex Upgrade MS 3B SW-3 MS 3B Blk 3 IOC Blk 3 Engineering Eng Dev Eng Dev DES Rev

CMMI (registered trademark) for Services (CMMI-SVC) Overview for Workshop

DTIC Science & Technology

2008-08-01

is from “DoD throws light on how it buys services [GCN 2006].” GAO data is from GAO report GAO-07-20. 5 CMMI for Services (CMMI-SVC) Forrester...Service Addition PAs 3 5 1 22 % of CMMI-DEV PAs are reused; % of Corporate Investments are potentially r usable! CMMI-DEV CMMI-ACQ CMMI-SVC 77...Service Modifications: •  21 amplification in 7 PAs •  5 added references •  1 modified PA (REQM) •  1 specific goal •  2 specific practices

Interim Radiological Scoping and Characterization Survey Report, 1963 Igloo 572 Accident (Former Medina Base), Lackland Training Annex, Lackland AFB, Texas

DTIC Science & Technology

2002-03-01

9045 4 8985 4 9001 5 8804 5 8893 Mean: 8788.8 Mean: 8925.4 Expected S.D.: 93.7 Expected S.D.: 94.5 Standard Dev.: 136.9 Standard Dev.: 107.4 Variance...subject to lit]) severe criminal penalties. Dissemination in 200204 5 042accordance with DoD Directive 5230.25" Air Force Institute for Environment...COVERED March 2002 INTERIM (2001 - 2002) 4. TITLE AND SUBTITLE 5 . FUNDING NUMBERS Interim Radiological Scoping and Characterization Survey Report, 1963

Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo.

PubMed

Leese, Henry J; Guerif, Fabrice; Allgar, Victoria; Brison, Daniel R; Lundin, Kersti; Sturmey, Roger G

2016-09-01

The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese, 2002 BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activity and kinetics of preimplantation development alongside the concept that an optimal range of such indices and of energetic efficiency influences embryogenesis. It is concluded that these considerations may be rationalized by proposing the existence of a "Goldilocks zone," or as it is known in Sweden, of lagom-meaning "just the right amount"-within which embryos with maximum developmental potential can be categorized. Mol. Reprod. Dev. 83: 748-754, 2016 © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Fourth Bionanotox and Applications Research Conference, 2009

NASA Astrophysics Data System (ADS)

Camp, Judy

2010-04-01

"Anticipating the future" seemed the common challenge for scientists attending the 4th BioNanoTox and Applications Research Conference in Little Rock, AR, October 21-22, 2009. Over 50 participants in multi-disciplines such as biology, chemistry, physics, medicine, medical diagnostics, computer science and informatics, nanotechnology, toxicology, and pharmaceutical science gathered to share their research data. From topics on water and food resources to space exploration to conservation to understanding biological activities and using instruments and computers that process enormous data, participants shared research approaches from different fields to find common themes in this integrated field. Presentations aimed at preventing the harmful effects of scientific discoveries to animals, humans, plants, and environment; at controlling infections; and at optimizing health care. The conference included addresses from Thomas Flammang, PhD, of the Food and Drug Administration, National Center for Toxicological Research in Jefferson, AR; Little Rock City Mayor Mark Stodola; and two keynote speakers. Keynote lectures by Danuta Leszczynska, PhD, from the Department of Civil and Environmental Engineering, Interdisciplinary Nanotoxicity Center, in Jackson, MS, and by Keith Cowan, PhD, from the Institute for Environmental Biotechnology in Grahamstown, South Africa, highlighted current trends and future challenges of nanoparticle research and of bioprocess technologies. Additionally, 25 graduate and undergraduate students presented research posters, resulting in valuable discussion among the varied participants; three student projects were selected for awards.

Arabidopsis MALE STERILITY1 Encodes a PHD-Type Transcription Factor and Regulates Pollen and Tapetum Development[W

PubMed Central

Ito, Takuya; Nagata, Noriko; Yoshiba, Yoshu; Ohme-Takagi, Masaru; Ma, Hong; Shinozaki, Kazuo

2007-01-01

The Arabidopsis thaliana MALE STERILITY1 (MS1) gene encodes a nuclear protein with Leu zipper–like and PHD-finger motifs and is important for postmeiotic pollen development. Here, we examined MS1 function using both cell biological and molecular biological approaches. We introduced a fusion construct of MS1 and a transcriptional repression domain (MS1-SRDX) into wild-type Arabidopsis, and the transgenic plants showed a semisterile phenotype similar to that of ms1. Since the repression domain can convert various kinds of transcriptional activators to dominant repressors, this suggested that MS1 functioned as a transcriptional activator. The Leu zipper–like region and the PHD motif were required for the MS1 function. Phenotypic analysis of the ms1 mutant and the MS1-SRDX transgenic Arabidopsis indicated that MS1 was involved in formation of pollen exine and pollen cytosolic components as well as tapetum development. Next, we searched for MS1 downstream genes by analyzing publicly available microarray data and identified 95 genes affected by MS1. Using a transgenic ms1 plant showing dexamethasone-inducible recovery of fertility, we further examined whether these genes were immediately downstream of MS1. From these results, we discuss a role of MS1 in pollen and tapetum development and the conservation of MS1 function in flowering plants. PMID:18032630

76 FR 36551 - Government-Owned Inventions; Availability for Licensing

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2011-06-22

...-exclusive licensing as a Biological material/Research tool. Licensing Contact: David A. Lambertson, PhD; 301... of Federally-funded research and development. Foreign patent applications are filed on selected...-4632; [email protected] . Collaborative Research Opportunity: The Center for Cancer Research...

77 FR 19004 - Marine Mammals; File No. 16621

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2012-03-29

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78 FR 15933 - Marine Mammals; File No. 17952

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2013-03-13

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Philip T. Pienkos | NREL

Science.gov Websites

Valorization: Development of a Methane-to-Adipic Acid Bioprocess (consultant) Areas of Expertise Molecular engineering Enzyme and protein engineering Techno-economic analysis Education Ph.D., Molecular Biology Principal Research Supervisor, NREL, Aug. 2007-May 2011 Research Director, Molecular Logix, Inc., The

Experiences Supporting the Lunar Reconnaissance Orbiter Camera: the Devops Model

NASA Astrophysics Data System (ADS)

Licht, A.; Estes, N. M.; Bowman-Cisnesros, E.; Hanger, C. D.

2013-12-01

Introduction: The Lunar Reconnaissance Orbiter Camera (LROC) Science Operations Center (SOC) is responsible for instrument targeting, product processing, and archiving [1]. The LROC SOC maintains over 1,000,000 observations with over 300 TB of released data. Processing challenges compound with the acquisition of over 400 Gbits of observations daily creating the need for a robust, efficient, and reliable suite of specialized software. Development Environment: The LROC SOC's software development methodology has evolved over time. Today, the development team operates in close cooperation with the systems administration team in a model known in the IT industry as DevOps. The DevOps model enables a highly productive development environment that facilitates accomplishment of key goals within tight schedules[2]. The LROC SOC DevOps model incorporates industry best practices including prototyping, continuous integration, unit testing, code coverage analysis, version control, and utilizing existing open source software. Scientists and researchers at LROC often prototype algorithms and scripts in a high-level language such as MATLAB or IDL. After the prototype is functionally complete the solution is implemented as production ready software by the developers. Following this process ensures that all controls and requirements set by the LROC SOC DevOps team are met. The LROC SOC also strives to enhance the efficiency of the operations staff by way of weekly presentations and informal mentoring. Many small scripting tasks are assigned to the cognizant operations personnel (end users), allowing for the DevOps team to focus on more complex and mission critical tasks. In addition to leveraging open source software the LROC SOC has also contributed to the open source community by releasing Lunaserv [3]. Findings: The DevOps software model very efficiently provides smooth software releases and maintains team momentum. Scientists prototyping their work has proven to be very efficient as developers do not need to spend time iterating over small changes. Instead, these changes are realized in early prototypes and implemented before the task is seen by developers. The development practices followed by the LROC SOC DevOps team help facilitate a high level of software quality that is necessary for LROC SOC operations. Application to the Scientific Community: There is no replacement for having software developed by professional developers. While it is beneficial for scientists to write software, this activity should be seen as prototyping, which is then made production ready by professional developers. When constructed properly, even a small development team has the ability to increase the rate of software development for a research group while creating more efficient, reliable, and maintainable products. This strategy allows scientists to accomplish more, focusing on teamwork, rather than software development, which may not be their primary focus. 1. Robinson et al. (2010) Space Sci. Rev. 150, 81-124 2. DeGrandis. (2011) Cutter IT Journal. Vol 24, No. 8, 34-39 3. Estes, N.M.; Hanger, C.D.; Licht, A.A.; Bowman-Cisneros, E.; Lunaserv Web Map Service: History, Implementation Details, Development, and Uses, http://adsabs.harvard.edu/abs/2013LPICo1719.2609E.

Turbulence and fire-spotting effects into wild-land fire simulators

NASA Astrophysics Data System (ADS)

Kaur, Inderpreet; Mentrelli, Andrea; Bosseur, Frédéric; Filippi, Jean-Baptiste; Pagnini, Gianni

2016-10-01

This paper presents a mathematical approach to model the effects and the role of phenomena with random nature such as turbulence and fire-spotting into the existing wildfire simulators. The formulation proposes that the propagation of the fire-front is the sum of a drifting component (obtained from an existing wildfire simulator without turbulence and fire-spotting) and a random fluctuating component. The modelling of the random effects is embodied in a probability density function accounting for the fluctuations around the fire perimeter which is given by the drifting component. In past, this formulation has been applied to include these random effects into a wildfire simulator based on an Eulerian moving interface method, namely the Level Set Method (LSM), but in this paper the same formulation is adapted for a wildfire simulator based on a Lagrangian front tracking technique, namely the Discrete Event System Specification (DEVS). The main highlight of the present study is the comparison of the performance of a Lagrangian and an Eulerian moving interface method when applied to wild-land fire propagation. Simple idealised numerical experiments are used to investigate the potential applicability of the proposed formulation to DEVS and to compare its behaviour with respect to the LSM. The results show that DEVS based wildfire propagation model qualitatively improves its performance (e.g., reproducing flank and back fire, increase in fire spread due to pre-heating of the fuel by hot air and firebrands, fire propagation across no fuel zones, secondary fire generation, ...) when random effects are included according to the present formulation. The performance of DEVS and LSM based wildfire models is comparable and the only differences which arise among the two are due to the differences in the geometrical construction of the direction of propagation. Though the results presented here are devoid of any validation exercise and provide only a proof of concept, they show a strong inclination towards an intended operational use. The existing LSM or DEVS based operational simulators like WRF-SFIRE and ForeFire respectively can serve as an ideal basis for the same.

Evaluating metrics of local topographic position for multiscale geomorphometric analysis

NASA Astrophysics Data System (ADS)

Newman, D. R.; Lindsay, J. B.; Cockburn, J. M. H.

2018-07-01

The field of geomorphometry has increasingly moved towards the use of multiscale analytical techniques, due to the availability of fine-resolution digital elevation models (DEMs) and the inherent scale-dependency of many DEM-derived attributes such as local topographic position (LTP). LTP is useful for landform and soils mapping and numerous other environmental applications. Multiple LTP metrics have been proposed and applied in the literature; however, elevation percentile (EP) is notable for its robustness to elevation error and applicability to non-Gaussian local elevation distributions, both of which are common characteristics of DEM data sets. Multiscale LTP analysis involves the estimation of spatial patterns using a range of neighborhood sizes, traditionally achieved by applying spatial filtering techniques with varying kernel sizes. While EP can be demonstrated to provide accurate estimates of LTP, the computationally intensive method of its calculation makes it unsuited to multiscale LTP analysis, particularly at large neighborhood sizes or with fine-resolution DEMs. This research assessed the suitability of three LTP metrics for multiscale terrain characterization by quantifying their computational efficiency and by comparing their ability to approximate EP spatial patterns under varying topographic conditions. The tested LTP metrics included: deviation from mean elevation (DEV), percent elevation range (PER), and the novel relative topographic position (RTP) index. The results demonstrated that DEV, calculated using the integral image technique, offers fast and scale-invariant computation. DEV spatial patterns were strongly correlated with EP (r2 range of 0.699 to 0.967) under all tested topographic conditions. RTP was also a strong predictor of EP (r2 range of 0.594 to 0.917). PER was the weakest predictor of EP (r2 range of 0.031 to 0.801) without offering a substantial improvement in computational efficiency over RTP. PER was therefore determined to be unsuitable for most multiscale applications. It was concluded that the scale-invariant property offered by the integral image used by the DEV method counters the minor losses in robustness compared to EP, making DEV the optimal LTP metric for multiscale applications.

Differences between individual and societal health state valuations: any link with personality?

PubMed

Chapman, Benjamin P; Franks, Peter; Duberstein, Paul R; Jerant, Anthony

2009-08-01

The concept of "adaptation" has been proposed to account for differences between individual and societal valuations of specific health states in patients with chronic diseases. Little is known about psychological indices of adaptational capacity, which may predict differences in individual and societal valuations of health states. We investigated whether such differences were partially explained by personality traits in chronic disease patients. Analysis of baseline data of randomized controlled trial. Three hundred seventy patients with chronic disease. The NEO-five factor inventory measure of personality, EuroQoL-5D (EQ-5D) societal-based, and the EQ visual analogue scale individually-based measures of health valuation. Regression analyses modeled Dev, a measure of difference between the EQ-Visual Analogue Scale and EQ-5D, as a function of personality traits, sociodemographic factors, and chronic diseases. Individual valuations were significantly and clinically higher than societal valuations among patients in the second and third quartile of conscientiousness (Dev = 0.08, P = 0.01); among covariates, only depression (Dev = -0.04, P = 0.046) was also associated with Dev. Compared with societal valuations of a given health state, persons at higher quartiles of conscientiousness report less disutility associated with poor health. The effect is roughly twice that of some estimates of minimally important clinical differences on the EQ-5D and of depression. Although useful at the aggregate level, societal preference measures may systematically undervalue the health states of more conscientious individuals. Future work should examine the impact this has on individual patient outcome evaluation in clinical studies.

Differences Between Individual and Societal Health State Valuations

PubMed Central

Chapman, Benjamin P.; Franks, Peter; Duberstein, Paul R.; Jerant, Anthony

2009-01-01

Objective The concept of “adaptation” has been proposed to account for differences between individual and societal valuations of specific health states in patients with chronic diseases. Little is known about psychological indices of adaptational capacity, which may predict differences in individual and societal valuations of health states. We investigated whether such differences were partially explained by personality traits in chronic disease patients. Research Design Analysis of baseline data of randomized controlled trial. Subjects Three hundred seventy patients with chronic disease. Measures The NEO-five factor inventory measure of personality, EuroQoL-5D (EQ-5D) societal-based, and the EQ visual analogue scale individually-based measures of health valuation. Results Regression analyses modeled Dev, a measure of difference between the EQ-Visual Analogue Scale and EQ-5D, as a function of personality traits, sociodemographic factors, and chronic diseases. Individual valuations were significantly and clinically higher than societal valuations among patients in the second and third quartile of conscientiousness (Dev = 0.08, P = 0.01); among covariates, only depression (Dev = -0.04, P = 0.046) was also associated with Dev. Conclusion Compared with societal valuations of a given health state, persons at higher quartiles of conscientiousness report less disutility associated with poor health. The effect is roughly twice that of some estimates of minimally important clinical differences on the EQ-5D and of depression. Although useful at the aggregate level, societal preference measures may systematically undervalue the health states of more conscientious individuals. Future work should examine the impact this has on individual patient outcome evaluation in clinical studies. PMID:19543121

Time-to-Credit Gender Inequities of First-Year PhD Students in the Biological Sciences.

PubMed

Feldon, David F; Peugh, James; Maher, Michelle A; Roksa, Josipa; Tofel-Grehl, Colby

2017-01-01

Equitable gender representation is an important aspect of scientific workforce development to secure a sufficient number of individuals and a diversity of perspectives. Biology is the most gender equitable of all scientific fields by the marker of degree attainment, with 52.5% of PhDs awarded to women. However, equitable rates of degree completion do not translate into equitable attainment of faculty or postdoctoral positions, suggesting continued existence of gender inequalities. In a national cohort of 336 first-year PhD students in the biological sciences (i.e., microbiology, cellular biology, molecular biology, developmental biology, and genetics) from 53 research institutions, female participants logged significantly more research hours than males and were significantly more likely than males to attribute their work hours to the demands of their assigned projects over the course of the academic year. Despite this, males were 15% more likely to be listed as authors on published journal articles, indicating inequality in the ratio of time to credit. Given the cumulative advantage that accrues for students who publish early in their graduate careers and the central role that scholarly productivity plays in academic hiring decisions, these findings collectively point to a major potential source of persisting underrepresentation of women on university faculties in these fields. © 2017 D. F. Feldon et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Immediate Force Loss after Eccentric Contractions is Increased with L-NAME Administration, a Nitric Oxide Synthase Inhibitor

DTIC Science & Technology

2013-02-01

myopathic conditions (e.g., Duchenne muscular dystrophy ). NO has been shown to play a role in muscle regeneration after injury. However, less is known about...and CHRISTOPHER P. INGALLS, PhD Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, Georgia, USA...Abstract Introduction—Nitric oxide (NO) signaling regulates many biological processes in skeletal muscle , wherein aberrant signaling contributes to

Interaction between EphrinB1 and CNK1 Found to Play Role in Tumor Progression | Poster

Cancer.gov

By Nancy Parrish, Staff Writer The family of proteins known as ephrins plays a critical role in a variety of biological processes. In a recent article in the Journal of Biological Chemistry, Hee Jun Cho, Ph.D., and colleagues report on the interaction between proteins CNK1 and ephrinB1 that promotes cell movement. Their findings may have an important implication in developing

A Novel Strategy for Isolation, Molecular and Functional Characterization of Embryonic Mammary Stem Cells Using Molecular Genetics and Microfluidic Sorting

DTIC Science & Technology

2008-06-01

Geoffrey M. Wahl, Ph.D. CONTRACTING ORGANIZATION: The Salk Institute for Biological Studies La Jolla, CA 92037-1099...PERFORMING ORGANIZATION REPORT NUMBER The Salk Institute for Biological Studies La Jolla, CA 92037-1099 9. SPONSORING...validated the use of a micro- volume cell sorter ( Celula , Inc.). This instrument is capable of sorting as few as 150 GFP positive cells from a sample

A Simulation Model for Studying Effects of Pollution and Freshwater Inflow on Secondary Productivity in an Ecosystem. Ph.D. Thesis - North Carolina State Univ.

NASA Technical Reports Server (NTRS)

Johnson, R. W.

1974-01-01

A mathematical model of an ecosystem is developed. Secondary productivity is evaluated in terms of man related and controllable factors. Information from an existing physical parameters model is used as well as pertinent biological measurements. Predictive information of value to estuarine management is presented. Biological, chemical, and physical parameters measured in order to develop models of ecosystems are identified.

Connecting Theory and Applications Across Complex Systems

DTIC Science & Technology

2004-01-01

applications in biology and computer science. Fernando Pacanini received his Ingeniero Electricista and Licenciado en Matematica degrees from the...Carlson (pdf) (Pd ) breaks 3:30-4:00 10:30-11:00 3:30-4:00 10:30-11:00 El -Samad / Biology Arkin (ndf) Savageau (ndf) Mitra (tdf) Khammash (Pdf...including the Internet and forest ecology. Hana El -Samad is a PhD candidate at the Mechanical Engineering department of the University of California at

78 FR 51195 - National Institute on Aging; Notice of Closed Meeting

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2013-08-20

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging... personal privacy. Name of Committee: National Institute on Aging Initial Review Group; Biological Aging... 20814. Contact Person: Bita Nakhai, Ph.D., Scientific Review Branch, National Institute On Aging...

75 FR 20852 - Center for Scientific Review; Notice of Closed Meetings

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2010-04-21

...: Biological Chemistry and Macromolecular Biophysics. Date: May 26-27, 2010. Time: 11 a.m. to 10 p.m. Agenda..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: Donald L. Schneider, PhD, Scientific Review Officer..., Bethesda, MD 20892 (Telephone Conference Call). [[Page 20853

76 FR 576 - National Cancer Institute; Notice of Closed Meetings

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2011-01-05

..., Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of...: Wlodek Lopaczynski, M.D., PhD, Scientific Review Officer, Research Programs Review Branch, Division of... Institute Special Emphasis Panel; Collaborative Research in Integrative Cancer Biology and the Tumor...

76 FR 28422 - Marine Mammals; File No. 16053

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2011-05-17

... Paul E. Nachtigall, PhD, Marine Mammal Research Program Hawaii Institute of Marine Biology, P.O. Box... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA384 Marine Mammals; File No. 16053 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric...

78 FR 21347 - Marine Mammals; File No. 17344

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2013-04-10

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC588 Marine Mammals; File No. 17344 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Samuel Wasser, Ph.D., University of Washington, Department of Biology, P.O. Box 351800, Seattle, WA 98195...

75 FR 49465 - Marine Mammals; File No. 14682

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2010-08-13

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78 FR 37796 - Marine Mammals; File No. 17952

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2013-06-24

... permit has been issued to Daniel P. Costa, Ph.D., Department of Biology and Institute of Marine Sciences... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC554 Marine Mammals; File No. 17952 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric...

76 FR 20324 - Endangered Species; File No. 15606

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

..., Ph.D., Texas A&M University at Galveston, Department of Marine Biology, 5007 Avenue U, Galveston, TX... Species; File No. 15606 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Education Division, Office of Protected Resources, National Marine Fisheries Service. [FR Doc. 2011-8593...

77 FR 28613 - National Cancer Institute; Notice of Closed Meetings

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2012-05-15

... Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd., Suite.... Contact Person: Savvas C. Makrides, Ph.D., Scientific Review Officer, Special Review and Logistics Branch..., Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology...

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2013-05-14

...: Caterina Bianco, MD, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of... Officer, Research Programs Review Branch, Division of Extramural Activities, National Cancer Institute....396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399...

ProThera Biologics, Inc.: a novel immunomodulator and biomarker for life-threatening diseases.

PubMed

Lim, Yow-Pin

2013-02-01

ProThera Biologics is a development stage bio-therapeutics company in East Providence, Rhode Island. The company was founded in 2002 to focus on the critical role and commercial potential of Inter-alpha Inhibitor Proteins (IAIP) for treating acute life-threatening inflammatory diseases. The discovery research originated in the basic research laboratories of the co-founders, Yow-Pin Lim, MD, PhD, and Douglas C. Hixson, PhD, at Rhode Island Hospital, a Lifespan partner. The company is backed by the Slater Technology Fund and has received research grants from the Rhode Island State Science and Technology Council (RI STAC) as well as continuous funding from the National Institutes of Health (NIH), with several Phase I and II Small Business Innovation Research (SBIR) grants over the past 10 years. ProThera has developed a novel process to purify Inter-alpha Inhibitor Proteins from source material, and has conducted groundbreaking research into the usage of IAIP to fight systemic inflammation.

Graduate Training at the Interface of Computational and Experimental Biology: An Outcome Report from a Partnership of Volunteers between a University and a National Laboratory.

PubMed

von Arnim, Albrecht G; Missra, Anamika

2017-01-01

Leading voices in the biological sciences have called for a transformation in graduate education leading to the PhD degree. One area commonly singled out for growth and innovation is cross-training in computational science. In 1998, the University of Tennessee (UT) founded an intercollegiate graduate program called the UT-ORNL Graduate School of Genome Science and Technology in partnership with the nearby Oak Ridge National Laboratory. Here, we report outcome data that attest to the program's effectiveness in graduating computationally enabled biologists for diverse careers. Among 77 PhD graduates since 2003, the majority came with traditional degrees in the biological sciences, yet two-thirds moved into computational or hybrid (computational-experimental) positions. We describe the curriculum of the program and how it has changed. We also summarize how the program seeks to establish cohesion between computational and experimental biologists. This type of program can respond flexibly and dynamically to unmet training needs. In conclusion, this study from a flagship, state-supported university may serve as a reference point for creating a stable, degree-granting, interdepartmental graduate program in computational biology and allied areas. © 2017 A. G. von Arnim and A. Missra. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Laser Bioeffects Resulting from Non-Linear Interactions of Ultrashort Pulses with Biological Systems

DTIC Science & Technology

2004-07-01

project Saher Maswadi, Ph.D. (Postdoctoral Fellow) 100% on project Manuscripts submitted/published: Glickman RD. Phototoxicity to the retina...with Dr. Saher Maswadi, the AFOSR- supported postdoctoral fellow in my laboratory, we have implemented a non-invasive method for measuring absolute

77 FR 12318 - National Cancer Institute; Notice of Closed Meetings

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2012-02-29

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2010-05-17

... Environmental Health Sciences; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... Health Sciences Special Emphasis Panel, Linking nanomaterial physical characteristics with biological...: Sally Eckert-Tilotta, PhD, Scientific Review Officer, Nat. Institute of Environmental Health Sciences...

Educating future nursing scientists: Recommendations for integrating omics content in PhD programs.

PubMed

Conley, Yvette P; Heitkemper, Margaret; McCarthy, Donna; Anderson, Cindy M; Corwin, Elizabeth J; Daack-Hirsch, Sandra; Dorsey, Susan G; Gregory, Katherine E; Groer, Maureen W; Henly, Susan J; Landers, Timothy; Lyon, Debra E; Taylor, Jacquelyn Y; Voss, Joachim

2015-01-01

Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and health care/biomedical science. A field of inquiry that holds great potential to influence our understanding of the underlying biology and mechanisms of health and disease is omics. For the purpose of this article, omics refers to genomics, transcriptomics, proteomics, epigenomics, exposomics, microbiomics, and metabolomics. Traditionally, most PhD programs in schools of nursing do not incorporate this content into their core curricula. As part of the Council for the Advancement of Nursing Science's Idea Festival for Nursing Science Education, a work group charged with addressing omics preparation for the next generation of nursing scientists was convened. The purpose of this article is to describe key findings and recommendations from the work group that unanimously and enthusiastically support the incorporation of omics content into the curricula of PhD programs in nursing. The work group also calls to action faculty in schools of nursing to develop strategies to enable students needing immersion in omics science and methods to execute their research goals. Copyright © 2015 Elsevier Inc. All rights reserved.

Sirt1 Protects Stressed Adult Hematopoietic Stem Cells | Center for Cancer Research

Cancer.gov

The immune system relies on a stable pool of hematopoietic stem and progenitor cells (HSPCs) to respond properly to injury or stress. Maintaining genomic integrity and appropriate gene expression is essential for HSPC homeostasis, and dysregulation can result in myeloproliferative disorders or loss of immune function. Sirt1 is a histone deacetylase that can protect embryonic stem (ES) cells from accumulating DNA damage and has been linked to hematopoietic differentiation of ES cells. Satyendra Singh, Ph.D., a postdoctoral fellow working with Philipp Oberdoerffer, Ph.D., in CCR’s Laboratory of Receptor Biology and Gene Expression, and their colleagues set out to determine whether Sirt1 could play a similar protective role in adult HSPCs.

Deriving neural network controllers from neuro-biological data: implementation of a single-leg stick insect controller.

PubMed

von Twickel, Arndt; Büschges, Ansgar; Pasemann, Frank

2011-02-01

This article presents modular recurrent neural network controllers for single legs of a biomimetic six-legged robot equipped with standard DC motors. Following arguments of Ekeberg et al. (Arthropod Struct Dev 33:287-300, 2004), completely decentralized and sensori-driven neuro-controllers were derived from neuro-biological data of stick-insects. Parameters of the controllers were either hand-tuned or optimized by an evolutionary algorithm. Employing identical controller structures, qualitatively similar behaviors were achieved for robot and for stick insect simulations. For a wide range of perturbing conditions, as for instance changing ground height or up- and downhill walking, swing as well as stance control were shown to be robust. Behavioral adaptations, like varying locomotion speeds, could be achieved by changes in neural parameters as well as by a mechanical coupling to the environment. To a large extent the simulated walking behavior matched biological data. For example, this was the case for body support force profiles and swing trajectories under varying ground heights. The results suggest that the single-leg controllers are suitable as modules for hexapod controllers, and they might therefore bridge morphological- and behavioral-based approaches to stick insect locomotion control.

The Role of Skp2 in the Prostate Tumorigenesis Following Rb and p53 Loss

DTIC Science & Technology

2014-10-01

of Developmental and Molecular Biology Room 521 Ullmann 1300 Morris Park Avenue Bronx, NY 10461-1975 AND ADDRESS(ES) 8. PERFORMING...ORGANIZATION REPORT NUMBER rt t f l t l Molecular Biology Room 521 Ullmann 1300 Morris Park Avenue Bronx, NY 10461-1975...Congratulations! Mary Anne Clifford Tuesday , October 21, 2014 1:33 PM October 21, 2014 Hongling Zhao, M.D., Ph.D. Department of DMB Ullmann - 521 Dear

Cheering for Team Science | Office of Cancer Genomics

Cancer.gov

As a graduate student, my PhD thesis focused on the function of a single human gene, within a genome of some 20,000 genes. Although this sometimes made my work seem insignificant, I was reminded of how important one small piece of a large puzzle can be when I discovered all the ways the gene knockout cells were disadvantaged. Studying the basic biology of our cells made me appreciate the beautiful complexity of human biology.

Environmental Assessment for the Outgrant of Real Estate and Construction of JP-8 Pipeline and Receiving Facility at Travis Air Force Base

DTIC Science & Technology

2009-11-01

ruderal plant vegetation. The area does not consist of a unique or ecologically sensitive habitat; therefore, potential impacts to vegetation would be...Name Degree Resource(s) Years of Experience Henry, Michael PhD, Ecology , Evolution , and Marine Biology B.S., Aquatic Biology -Lead Technical...Management. August. Fairfield, CA. Solano County. 2007. Final Environment Impact Report (EIR)—Montezuma Wind Plant Project. Prepared by Ecology and

The Northern Circumpolar Soil Carbon Database: spatially distributed datasets of soil coverage and soil carbon storage in the northern permafrost regions

NASA Astrophysics Data System (ADS)

Hugelius, G.; Tarnocai, C.; Broll, G.; Canadell, J. G.; Kuhry, P.; Swanson, D. K.

2012-08-01

High latitude terrestrial ecosystems are key components in the global carbon (C) cycle. Estimates of global soil organic carbon (SOC), however, do not include updated estimates of SOC storage in permafrost-affected soils or representation of the unique pedogenic processes that affect these soils. The Northern Circumpolar Soil Carbon Database (NCSCD) was developed to quantify the SOC stocks in the circumpolar permafrost region (18.7 × 106 km2). The NCSCD is a polygon-based digital database compiled from harmonized regional soil classification maps in which data on soil order coverage has been linked to pedon data (n = 1647) from the northern permafrost regions to calculate SOC content and mass. In addition, new gridded datasets at different spatial resolutions have been generated to facilitate research applications using the NCSCD (standard raster formats for use in Geographic Information Systems and Network Common Data Form files common for applications in numerical models). This paper describes the compilation of the NCSCD spatial framework, the soil sampling and soil analyses procedures used to derive SOC content in pedons from North America and Eurasia and the formatting of the digital files that are available online. The potential applications and limitations of the NCSCD in spatial analyses are also discussed. The database has the doi:10.5879/ecds/00000001. An open access data-portal with all the described GIS-datasets is available online at: http://dev1.geo.su.se/bbcc/dev/ncscd/.

Oscillatory support for rapid frequency change processing in infants.

PubMed

Musacchia, Gabriella; Choudhury, Naseem A; Ortiz-Mantilla, Silvia; Realpe-Bonilla, Teresa; Roesler, Cynthia P; Benasich, April A

2013-11-01

Rapid auditory processing and auditory change detection abilities are crucial aspects of speech and language development, particularly in the first year of life. Animal models and adult studies suggest that oscillatory synchrony, and in particular low-frequency oscillations play key roles in this process. We hypothesize that infant perception of rapid pitch and timing changes is mediated, at least in part, by oscillatory mechanisms. Using event-related potentials (ERPs), source localization and time-frequency analysis of event-related oscillations (EROs), we examined the neural substrates of rapid auditory processing in 4-month-olds. During a standard oddball paradigm, infants listened to tone pairs with invariant standard (STD, 800-800 Hz) and variant deviant (DEV, 800-1200 Hz) pitch. STD and DEV tone pairs were first presented in a block with a short inter-stimulus interval (ISI) (Rapid Rate: 70 ms ISI), followed by a block of stimuli with a longer ISI (Control Rate: 300 ms ISI). Results showed greater ERP peak amplitude in response to the DEV tone in both conditions and later and larger peaks during Rapid Rate presentation, compared to the Control condition. Sources of neural activity, localized to right and left auditory regions, showed larger and faster activation in the right hemisphere for both rate conditions. Time-frequency analysis of the source activity revealed clusters of theta band enhancement to the DEV tone in right auditory cortex for both conditions. Left auditory activity was enhanced only during Rapid Rate presentation. These data suggest that local low-frequency oscillatory synchrony underlies rapid processing and can robustly index auditory perception in young infants. Furthermore, left hemisphere recruitment during rapid frequency change discrimination suggests a difference in the spectral and temporal resolution of right and left hemispheres at a very young age. © 2013 Elsevier Ltd. All rights reserved.

To Improve Biochemical Education around the World.

ERIC Educational Resources Information Center

Vella, F.

1991-01-01

The first part of this plenary lecture describes the activities of the Committee on Education of the International Union of Biochemistry. The second part describes the Educational Credo, standards for the PhD Degree in Biochemistry and Molecular Biology, and recommendations of the report "Physicians for the Twenty-First Century." (PR)

Brandy Heckman-Stoddard, PhD, MPH | Division of Cancer Prevention

Cancer.gov

Dr. Heckman-Stoddard received a Doctor of Philosophy degree in Molecular and Cellular Biology at Baylor College of Medicine focusing on the intersection of Rho and IGF signaling in mammary gland development and breast cancer before joining the National Cancer Institute as a Cancer Prevention Fellow. |

Harold Seifried, PhD | Division of Cancer Prevention

Cancer.gov

Dr. Harold Seifried is a member of the American Chemical Society Biological Chemistry Division; American College of Toxicology Industrial Toxicology Subcommittee; American Industrial Hygiene Association; Society of Toxicology; International Society for the Study of Xenobiotics; Diplomate of the American Board of Toxicology since 1980; American Board of Industrial Hygiene,

75 FR 71670 - Endangered Species; File No. 15606

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... Andre Landry, Ph.D., Texas A&M University at Galveston, Department of Marine Biology, 5007 Avenue U... Species; File No. 15606 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric..., National Marine Fisheries Service. [FR Doc. 2010-29667 Filed 11-23-10; 8:45 am] BILLING CODE 3510-22-P ...

77 FR 67341 - Endangered Species; File No. 15809

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

... Species; File No. 15809 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Paul Jobsis, Ph.D., University of the Virgin Islands, Department of Biology, 2 John Brewers Bay, St... of Protected Resources, National Marine Fisheries Service. [FR Doc. 2012-27343 Filed 11-8-12; 8:45 am...

75 FR 64316 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

... Review Branch, NINDS/NIH/DHHS, Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda..., PhD, Scientific Review Officer, Scientific Review Branch, NINDS/NIH/DHHS, Neuroscience Center, 6001... Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences...

75 FR 21640 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

..., Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, 6116....D., PhD, Scientific Review Officer, Research Programs Review Branch, Division of Extramural... & Tissue Biology P01. Date: May 26-28, 2010. Time: 5 p.m. to 5 p.m. Agenda: To review and evaluate grant...

76 FR 14675 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-17

... Biology. Date: May 16-18, 2011. Time: 4 p.m. to 5 p.m. Agenda: To review and evaluate grant applications... Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Boulevard, Room.... Wirth, PhD, Scientific Review Officer, Research Programs Review Branch, Division of Extramural...

Implementation of an education-focused PhD program in anatomy and cell biology at Indiana University: lessons learned and future challenges.

PubMed

Brokaw, James J; O'Loughlin, Valerie D

2015-01-01

In 2008, the Indiana University School of Medicine, in collaboration with the School of Education, admitted its first student to a newly approved PhD program in Anatomy and Cell Biology focusing on educational research rather than biomedical research. The goal of the program is twofold: (1) to provide students with extensive training in all of the anatomical disciplines coupled with sufficient teaching experience to assume major educational responsibilities upon graduation and (2) to train students to conduct rigorous medical education research and other scholarly work necessary for promotion and tenure. The 90 credit hour curriculum consists of biomedical courses taught within the School of Medicine and education courses taught within the School of Education, including courses in health sciences pedagogy, curriculum development, learning theory, quantitative, and qualitative research methods, statistics, and electives. To date, 16 students have entered the program, seven have passed their qualifying examinations, and five have earned their PhD degrees. Four students have received national recognition for their educational research and four graduates have obtained faculty appointments. Going forward, we must adapt the program's biomedical course requirements to incorporate the new integrated curriculum of the medical school, and we must secure additional funding to support more students. Overcoming these challenges will enable us to continue producing a small but stable supply of doctoral-level anatomy educators for a growing academic market. © 2014 American Association of Anatomists.

Using the Semantic Web for Rapid Integration of WikiPathways with Other Biological Online Data Resources

PubMed Central

Waagmeester, Andra; Pico, Alexander R.

2016-01-01

The diversity of online resources storing biological data in different formats provides a challenge for bioinformaticians to integrate and analyse their biological data. The semantic web provides a standard to facilitate knowledge integration using statements built as triples describing a relation between two objects. WikiPathways, an online collaborative pathway resource, is now available in the semantic web through a SPARQL endpoint at http://sparql.wikipathways.org. Having biological pathways in the semantic web allows rapid integration with data from other resources that contain information about elements present in pathways using SPARQL queries. In order to convert WikiPathways content into meaningful triples we developed two new vocabularies that capture the graphical representation and the pathway logic, respectively. Each gene, protein, and metabolite in a given pathway is defined with a standard set of identifiers to support linking to several other biological resources in the semantic web. WikiPathways triples were loaded into the Open PHACTS discovery platform and are available through its Web API (https://dev.openphacts.org/docs) to be used in various tools for drug development. We combined various semantic web resources with the newly converted WikiPathways content using a variety of SPARQL query types and third-party resources, such as the Open PHACTS API. The ability to use pathway information to form new links across diverse biological data highlights the utility of integrating WikiPathways in the semantic web. PMID:27336457

Using the Semantic Web for Rapid Integration of WikiPathways with Other Biological Online Data Resources.

PubMed

Waagmeester, Andra; Kutmon, Martina; Riutta, Anders; Miller, Ryan; Willighagen, Egon L; Evelo, Chris T; Pico, Alexander R

2016-06-01

The diversity of online resources storing biological data in different formats provides a challenge for bioinformaticians to integrate and analyse their biological data. The semantic web provides a standard to facilitate knowledge integration using statements built as triples describing a relation between two objects. WikiPathways, an online collaborative pathway resource, is now available in the semantic web through a SPARQL endpoint at http://sparql.wikipathways.org. Having biological pathways in the semantic web allows rapid integration with data from other resources that contain information about elements present in pathways using SPARQL queries. In order to convert WikiPathways content into meaningful triples we developed two new vocabularies that capture the graphical representation and the pathway logic, respectively. Each gene, protein, and metabolite in a given pathway is defined with a standard set of identifiers to support linking to several other biological resources in the semantic web. WikiPathways triples were loaded into the Open PHACTS discovery platform and are available through its Web API (https://dev.openphacts.org/docs) to be used in various tools for drug development. We combined various semantic web resources with the newly converted WikiPathways content using a variety of SPARQL query types and third-party resources, such as the Open PHACTS API. The ability to use pathway information to form new links across diverse biological data highlights the utility of integrating WikiPathways in the semantic web.

Predicting Sensitivity of Breast Tumors to Src-Targeted Therapies through Assessment of Cas/Src/BCAR3 Activity

DTIC Science & Technology

2016-10-01

Amy H. Bouton, Ph.D. Associate Dean of Graduate and Medical ScienXst Programs Professor of Microbiology , Immunology, and Cancer Biology Box...We found that all of the BCAR3 in invasive breast cancer cells is present in a complex with Cas and 1Department of Microbiology , Immunology and Cancer...Harrisonburg, VA, USA. Correspondence: Dr AH Bouton, Department of Microbiology , Immunology and Cancer Biology, University of Virginia School of Medicine, Box

Molecular Biology for the Environment: an EC-US hands-on Course in Environmental Biotechnology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Victor de Lorenzo; Juan Luis Ramos; Jerome Kukor

One of the central goals of this activity is to bring together young scientists (at the late Ph.D. or early postdoctoral stages of their careers) in a forum that should result in future collaborations. The course is designed to give scientists hands-on experience in modern, up-to-date biotechnological methods at the interface between molecular biology and environmental biotechnology for the analysis of microorganisms and their activities with regard to the remediation of pollutants in the environment.

Effects of Construction of the Digital Multipurpose Range Complex (DMPRC) on Riparian and Stream Ecosystems at Fort Benning, Georgia. Addendum

DTIC Science & Technology

2009-06-01

root dynamics in riparian forests. Soil Science Society of America 69(3):729-737. Houser, J. N., P. J. Mulholland, and K. O. Maloney. 2006. Upland...Forested Wetlands, D. M. Amatya and J. Nettles (eds). New Bern, NC. American Society of Agricultural and Biological Engineers, St. Joseph, MI...primary productivity, vegetation composition, structure, and fine root dynamics in riparian forests. Kelly O. Maloney, Ph.D. in Biological Sciences

A method for the direct measurement of electronic site populations in a molecular aggregate using two-dimensional electronic-vibrational spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Nicholas H. C.; Dong, Hui; Oliver, Thomas A. A.

2015-09-28

Two dimensional electronic spectroscopy has proven to be a valuable experimental technique to reveal electronic excitation dynamics in photosynthetic pigment-protein complexes, nanoscale semiconductors, organic photovoltaic materials, and many other types of systems. It does not, however, provide direct information concerning the spatial structure and dynamics of excitons. 2D infrared spectroscopy has become a widely used tool for studying structural dynamics but is incapable of directly providing information concerning electronic excited states. 2D electronic-vibrational (2DEV) spectroscopy provides a link between these domains, directly connecting the electronic excitation with the vibrational structure of the system under study. In this work, we derivemore » response functions for the 2DEV spectrum of a molecular dimer and propose a method by which 2DEV spectra could be used to directly measure the electronic site populations as a function of time following the initial electronic excitation. We present results from the response function simulations which show that our proposed approach is substantially valid. This method provides, to our knowledge, the first direct experimental method for measuring the electronic excited state dynamics in the spatial domain, on the molecular scale.« less

A method for the direct measurement of electronic site populations in a molecular aggregate using two-dimensional electronic-vibrational spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Nicholas H. C.; Dong, Hui; Oliver, Thomas A. A.

2015-09-28

Two dimensional electronic spectroscopy has proved to be a valuable experimental technique to reveal electronic excitation dynamics in photosynthetic pigment-protein complexes, nanoscale semiconductors, organic photovoltaic materials, and many other types of systems. It does not, however, provide direct information concerning the spatial structure and dynamics of excitons. 2D infrared spectroscopy has become a widely used tool for studying structural dynamics but is incapable of directly providing information concerning electronic excited states. 2D electronic-vibrational (2DEV) spectroscopy provides a link between these domains, directly connecting the electronic excitation with the vibrational structure of the system under study. In this work, we derivemore » response functions for the 2DEV spectrum of a molecular dimer and propose a method by which 2DEV spectra could be used to directly measure the electronic site populations as a function of time following the initial electronic excitation. We present results from the response function simulations which show that our proposed approach is substantially valid. This method provides, to our knowledge, the first direct experimental method for measuring the electronic excited state dynamics in the spatial domain, on the molecular scale.« less

A method for the direct measurement of electronic site populations in a molecular aggregate using two-dimensional electronic-vibrational spectroscopy.

PubMed

Lewis, Nicholas H C; Dong, Hui; Oliver, Thomas A A; Fleming, Graham R

2015-09-28

Two dimensional electronic spectroscopy has proved to be a valuable experimental technique to reveal electronic excitation dynamics in photosynthetic pigment-protein complexes, nanoscale semiconductors, organic photovoltaic materials, and many other types of systems. It does not, however, provide direct information concerning the spatial structure and dynamics of excitons. 2D infrared spectroscopy has become a widely used tool for studying structural dynamics but is incapable of directly providing information concerning electronic excited states. 2D electronic-vibrational (2DEV) spectroscopy provides a link between these domains, directly connecting the electronic excitation with the vibrational structure of the system under study. In this work, we derive response functions for the 2DEV spectrum of a molecular dimer and propose a method by which 2DEV spectra could be used to directly measure the electronic site populations as a function of time following the initial electronic excitation. We present results from the response function simulations which show that our proposed approach is substantially valid. This method provides, to our knowledge, the first direct experimental method for measuring the electronic excited state dynamics in the spatial domain, on the molecular scale.

A novel measure of ewe efficiency for breeding and benchmarking purposes.

PubMed

McHugh, Nóirín; Pabiou, Thierry; McDermott, Kevin; Wall, Eamon; Berry, Donagh P

2018-06-04

Ewe efficiency has traditionally been defined as the ratio of litter weight to ewe weight; given the statistical properties of ratio traits, an alternative strategy is proposed in the present study. The concept of using the deviation in performance of an animal from the population norm has grown in popularity as a measure of animal-level efficiency. The objective of the present study was to define novel measures of efficiency for sheep, which considers the combined weight of a litter of lambs relative to the weight of their dam, and vice versa. Two novel traits, representing the deviation in total litter weight at 40 d (DEV40L) or weaning (DEVweanL), were calculated as the residuals of a statistical model, with litter weight as the dependent variable and with the fixed effects of litter rearing size, contemporary group, and ewe weight. The deviation in ewe weight at 40-d postlambing (DEV40E) or weaning (DEVweanE) was derived using a similar approach but with ewe weight and litter weight interchanged as the dependent variable. Variance components for each trait were estimated by first deriving the litter or ewe weight deviation phenotype and subsequently estimating the variance components. The phenotypic SD in DEV40L and DEVweanL was 8.46 and 15.37 kg, respectively; the mean litter weight at 40 d and weaning was 30.97 and 47.68 kg, respectively. The genetic SD and heritability for DEV40L was 2.65 kg and 0.12, respectively. For DEVweanL, the genetic SD and heritability was 4.94 kg and 0.13, respectively. The average ewe weight at 40-d postlambing and at weaning was 66.43 and 66.87 kg, respectively. The genetic SD and heritability for DEV40E was 4.33 kg and 0.24, respectively. The heritability estimated for DEVweanE was 0.31. The traits derived in the present study may be useful not only for phenotypic benchmarking of ewes within flock on performance but also for benchmarking flocks against each other; furthermore, the extent of genetic variability in all traits, coupled with the fact that the data required to generate these novel phenotypes are usually readily available, signals huge potential within sheep breeding programs.

Modeling magnetic fields from a DC power cable buried beneath San Francisco Bay based on empirical measurements

DOE PAGES

Kavet, Robert; Wyman, Megan T.; Klimley, A. Peter; ...

2016-02-25

Here, the Trans Bay Cable (TBC) is a ±200-kilovolt (kV), 400 MW 85-km long High Voltage Direct Current (DC) buried transmission line linking Pittsburg, CA with San Francisco, CA (SF) beneath the San Francisco Estuary. The TBC runs parallel to the migratory route of various marine species, including green sturgeon, Chinook salmon, and steelhead trout. In July and August 2014, an extensive series of magnetic field measurements were taken using a pair of submerged Geometrics magnetometers towed behind a survey vessel in four locations in the San Francisco estuary along profiles that cross the cable’s path; these included the Sanmore » Francisco-Oakland Bay Bridge (BB), the Richmond-San Rafael Bridge (RSR), the Benicia- Martinez Bridge (Ben) and an area in San Pablo Bay (SP) in which a bridge is not present. In this paper, we apply basic formulas that ideally describe the magnetic field from a DC cable summed vectorially with the background geomagnetic field (in the absence of other sources that would perturb the ambient field) to derive characteristics of the cable that are otherwise not immediately observable. Magnetic field profiles from measurements taken along 170 survey lines were inspected visually for evidence of a distinct pattern representing the presence of the cable. Many profiles were dominated by field distortions unrelated to the cable caused by bridge structures or other submerged objects, and the cable’s contribution to the field was not detectable. BB, with 40 of the survey lines, did not yield usable data for these reasons. The unrelated anomalies could be up to 100 times greater than those from the cable. In total, discernible magnetic field profiles measured from 76 survey lines were regressed against the equations, representing eight days of measurement. The modeled field anomalies due to the cable (the difference between the maximum and minimum field along the survey line at the cable crossing) were virtually identical to the measured values. The modeling yielded a pooled cable depth below the bay floor of 2.06 m (±1.46 std dev), and estimated the angle to the horizontal of the imaginary line connecting the crosssectional center of the cable’s two conductors (0.1143 m apart) as 178.9° ±61.9° (std dev) for Ben, 78.6°±37.0° (std dev) for RSR, and 139.9°±27.4° (std dev) for SP. The mean of the eight daily average currents derived from the regressions was 986 ±185 amperes (A) (std dev), as compared to 722 ±95 A (std dev) provided by Trans Bay Cable LLC. Overall, the regressions based on fundamental principles (Biot Savart law) and the vectorial summation of cable and geomagnetic fields provide estimates of cable characteristics consistent with plausible expectations.« less

Modeling magnetic fields from a DC power cable buried beneath San Francisco Bay based on empirical measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kavet, Robert; Wyman, Megan T.; Klimley, A. Peter

Here, the Trans Bay Cable (TBC) is a ±200-kilovolt (kV), 400 MW 85-km long High Voltage Direct Current (DC) buried transmission line linking Pittsburg, CA with San Francisco, CA (SF) beneath the San Francisco Estuary. The TBC runs parallel to the migratory route of various marine species, including green sturgeon, Chinook salmon, and steelhead trout. In July and August 2014, an extensive series of magnetic field measurements were taken using a pair of submerged Geometrics magnetometers towed behind a survey vessel in four locations in the San Francisco estuary along profiles that cross the cable’s path; these included the Sanmore » Francisco-Oakland Bay Bridge (BB), the Richmond-San Rafael Bridge (RSR), the Benicia- Martinez Bridge (Ben) and an area in San Pablo Bay (SP) in which a bridge is not present. In this paper, we apply basic formulas that ideally describe the magnetic field from a DC cable summed vectorially with the background geomagnetic field (in the absence of other sources that would perturb the ambient field) to derive characteristics of the cable that are otherwise not immediately observable. Magnetic field profiles from measurements taken along 170 survey lines were inspected visually for evidence of a distinct pattern representing the presence of the cable. Many profiles were dominated by field distortions unrelated to the cable caused by bridge structures or other submerged objects, and the cable’s contribution to the field was not detectable. BB, with 40 of the survey lines, did not yield usable data for these reasons. The unrelated anomalies could be up to 100 times greater than those from the cable. In total, discernible magnetic field profiles measured from 76 survey lines were regressed against the equations, representing eight days of measurement. The modeled field anomalies due to the cable (the difference between the maximum and minimum field along the survey line at the cable crossing) were virtually identical to the measured values. The modeling yielded a pooled cable depth below the bay floor of 2.06 m (±1.46 std dev), and estimated the angle to the horizontal of the imaginary line connecting the crosssectional center of the cable’s two conductors (0.1143 m apart) as 178.9° ±61.9° (std dev) for Ben, 78.6°±37.0° (std dev) for RSR, and 139.9°±27.4° (std dev) for SP. The mean of the eight daily average currents derived from the regressions was 986 ±185 amperes (A) (std dev), as compared to 722 ±95 A (std dev) provided by Trans Bay Cable LLC. Overall, the regressions based on fundamental principles (Biot Savart law) and the vectorial summation of cable and geomagnetic fields provide estimates of cable characteristics consistent with plausible expectations.« less

The Poster Visits Nottingham Castle in England | Poster

Cancer.gov

By Nancy Parrish, Staff Writer Last September, Nadya Tarasova, Ph.D., head, Synthetic Biologics and Drug Discovery Facility, Cancer and Inflammation Program, traveled to Nottingham, England, where she was an invited speaker and chaired a session on JAK/STAT signaling in cancer at the second special meeting of the Federation of European Biochemical Societies (FEBS).

ASBESTOS-INDUCED ACTIVATION OF SIGNALING PATHWAYS IN HUMAN BRONCHIAL EPITHELIAL CELLS

EPA Science Inventory

Title: Asbestos-Induced Activation of Signaling Pathways in Human
Bronchial Epithelial Cells

X. Wang, MD 1, J. M. Samet, PhD 2 and A. J. Ghio, MD 2. 1 Center for
Environmental Medicine, Asthma and Lung Biology, University of North
Carolina, Chapel Hill, NC, Uni...

A Preliminary Theoretical Analysis of a Research Experience for Undergraduates Community Model

ERIC Educational Resources Information Center

Castillo-Garsow, Carlos; Castillo-Chavez, Carlos; Woodley, Sherry

2013-01-01

The Mathematical and Theoretical Biology Institute (MTBI) is a successful summer research experience for undergraduates, with a strong record of mentoring Ph.D. graduates, particularly, underrepresented minority students. However, the MTBI program was designed for education in research, not for research in education, and the mechanisms of the…

Agricultural Exposures, Multiple Myeloma Etiology: Profile of Jonathan Hofmann

Cancer.gov

Tenure-track investigator Jonathan Hofmann, Ph.D., M.P.H., has established a research program in the Occupational and Environmental Epidemiology Branch focused on the role of agricultural exposures in the etiology of multiple myeloma and other cancers, and on understanding the biological mechanisms that influence the development and progression of multiple myeloma.

Classical biological control of cassava pests in Latin America and Africa

USDA-ARS?s Scientific Manuscript database

Anthony (Tony) Bellotti’s career took him to El Salvador with the Peace Corps in 1962, New Mexico State for a Masters, Paraguay (again with the Peace Corps), Cornell University for a Ph.D., and Colombia where he worked for the Centro Internacional de Agricultura Tropical (CIAT) from 1974 until his p...

77 FR 26301 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

....396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399..., MD 20892 (Telephone Conference Call). Contact Person: Virginia P. Wray, Ph.D., Deputy Chief, Research... Special Emphasis Panel; Cell-Based Imaging. Date: June 19, 2012. Time: 1:00 p.m. to 4:00 p.m. Agenda: To...

Synthetic Spores Give Insight into the Real Thing and Reveal Functional Applications | Center for Cancer Research

Cancer.gov

Spores from bacteria, such as Bacillus subtilis, are produced to allow the bacterium’s genetic material to survive harsh environments. When the bacterium senses nutrient depletion, it divides asymmetrically into a forespore and a mother cell. The mother cell engulfs the forespore, and coat proteins synthesized by the mother cell localize to the surface of the forespore. The mother cell eventually ruptures, releasing the mature spore, which is surrounded by a thick shell of approximately 70 different proteins. This protein coat is one of the most durable static biological structures, but, because of its complexity, detailed studies of how the coat forms have been lacking. Kumaran Ramamurthi, Ph.D., of CCR’s Laboratory of Molecular Biology, and his colleagues including postdoctoral fellow and lead author of the study I-Lin Wu, Ph.D., decided to investigate the assembly of the basement layer of the spore coat by decorating spherical membranes supported by silica beads with SpoIVA and SpoVM, proteins which are known to be required for coat assembly.

Personal profile: interview with Bill Andrews, Ph.D.

PubMed

Andrews, Bill

2011-08-01

Dr. William H. Andrews has worked in the biotech industry for 31 years, focusing the last 19 years on finding ways to extend human life span through the intervention of telomere shortening in human cells. Dr. Andrews earned his Ph.D. in Molecular and Population Genetics at the University of Georgia. He was a Senior Scientist at Armos Corporation and Codon Corporation, Director of Molecular Biology at Codon and at Geron Corporation, and Director of Technology Development at EOS Biosciences. He is presently the founder, President, and CEO of Sierra Sciences, a biotechnology company focused exclusively on finding drugs that will transiently induce the expression of endogenous telomerase in human cells. Sierra Sciences has already identified more than 30 such drugs and is presently characterizing their mechanism of action. While Director of Molecular Biology at Geron Corporation, Dr. Andrews was one of the principal discoverers of both the RNA and protein components of human telomerase and was awarded second place as "National Inventor of the Year" in 1997 for this work. He is presently a named inventor on 43 U.S- issued telomerase patents.

How accurate is automated gap filling of metabolic models?

PubMed

Karp, Peter D; Weaver, Daniel; Latendresse, Mario

2018-06-19

Reaction gap filling is a computational technique for proposing the addition of reactions to genome-scale metabolic models to permit those models to run correctly. Gap filling completes what are otherwise incomplete models that lack fully connected metabolic networks. The models are incomplete because they are derived from annotated genomes in which not all enzymes have been identified. Here we compare the results of applying an automated likelihood-based gap filler within the Pathway Tools software with the results of manually gap filling the same metabolic model. Both gap-filling exercises were applied to the same genome-derived qualitative metabolic reconstruction for Bifidobacterium longum subsp. longum JCM 1217, and to the same modeling conditions - anaerobic growth under four nutrients producing 53 biomass metabolites. The solution computed by the gap-filling program GenDev contained 12 reactions, but closer examination showed that solution was not minimal; two of the twelve reactions can be removed to yield a set of ten reactions that enable model growth. The manually curated solution contained 13 reactions, eight of which were shared with the 12-reaction computed solution. Thus, GenDev achieved recall of 61.5% and precision of 66.6%. These results suggest that although computational gap fillers are populating metabolic models with significant numbers of correct reactions, automatically gap-filled metabolic models also contain significant numbers of incorrect reactions. Our conclusion is that manual curation of gap-filler results is needed to obtain high-accuracy models. Many of the differences between the manual and automatic solutions resulted from using expert biological knowledge to direct the choice of reactions within the curated solution, such as reactions specific to the anaerobic lifestyle of B. longum.

2.3 Å X-ray Structure of the Heme-Bound GAF Domain of Sensory Histidine Kinase DosT of Mycobacterium tuberculosis†

PubMed Central

Podust, Larissa M.; Ioanoviciu, Alexandra; Ortiz de Montellano, Paul R.

2009-01-01

Mycobacterium tuberculosis responds to the changes in environmental conditions through a two-component signaling system that detects reduced O2 tension and NO and CO exposures via the heme-binding GAF domains of two sensory histidine kinases, DosT and DevS, and the transcriptional regulator DosR. We report the first x-ray structure of the DosT heme-bound GAF domain (GAFDosT) in both oxy and deoxy forms determined to a resolution of 2.3 Å. In GAFDosT, heme binds in an orientation orthogonal to that in the PAS domains via a highly conserved motif including invariant H147 as a proximal heme axial ligand. On the distal side, invariant Y169 is in stacking interactions with the heme with its long axis parallel and the plane of the ring orthogonal to the heme plane. In one of the two protein monomers in an asymmetric unit, O2 binds as a second axial ligand to the heme iron, and is stabilized via an H-bond to the OH-group of Y169. The structure reveals two small tunnel-connected cavities and a pore on the protein surface that suggest a potential route for O2 access to the sensing pocket. The limited conformational differences observed between differently heme iron-ligated GAFDosT monomers in the asymmetric unit may result from crystal lattice limitations since atmospheric oxygen binding likely occurs in the crystal as a result of x-ray induced Fe3+ photoreduction during diffraction data collection. Determination of the GAFDosT structure sets up a framework in which to address ligand-recognition, discrimination, and signal propagation schemes in the heme-based GAF domains of biological sensors. PMID:18980385

Visually Tracking Translocations in Living Cells | Center for Cancer Research

Cancer.gov

Chromosomal translocations, the fusion of pieces of DNA from different chromosomes, are often observed in cancer cells and can even cause cancer. However, little is known about the dynamics and regulation of translocation formation. To investigate this critical process, Tom Misteli, Ph.D., in CCR’s Laboratory of Receptor Biology and Gene Expression, and his colleague Vassilis

CCR researchers show that blocking the estrogen receptor restores the sensitivity of lung cancer cells to therapy | Center for Cancer Research

Cancer.gov

Claudia Palena, Ph.D., of CCR’s Laboratory of Tumor Immunology and Biology, and her colleagues wondered if it would be possible to identify compounds that could reverse the therapy resistance imparted by the process called epithelial-mesenchymal transition (EMT) in lung cancer.

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

Our group is interested in developing novel epigenetic therapeutics for thoracic malignancies, especially small cell lung cancer. The successful candidate will perform studies to develop an effective drug combo from bench to bedside.  The candidate should have a PhD in Molecular Biology, Biochemistry or related disciplines.  The candidate will work with both cell models and animal models. 

Professional Training for TRADOC Environmental and Natural Resource Professionals. Volume 2. Source Listings

DTIC Science & Technology

1991-05-01

Plant Biology); Carol Augspurger 376 INSTITUTION; COOPERATOR University of Illinois, Urbana ( Ecology , Ethology & Evolution ...43 Ph.D. 33 33 33 1 STRENGTHS AND SPECIALTIES Subject Matter Strengths: Biogeography, community ecology , vertebrate ecology , plant /insect interactions ... ecology , population ecology of small mammals, avian ecology , plant /animal interactions . Formal Teaching/Research Arrangements With Other

A Discourse Analysis of Master's Theses across Disciplines with a Focus on Introductions

ERIC Educational Resources Information Center

Samraj, Betty

2008-01-01

There have been a growing number of discourse studies in recent years on written academic genres produced by students. However, the master's thesis has not received as much attention as the PhD dissertation. This investigation of master's theses from three disciplines, biology, philosophy and linguistics, employs both discourse analysis and…

Statistics in the Workplace: A Survey of Use by Recent Graduates with Higher Degrees

ERIC Educational Resources Information Center

Harraway, John A.; Barker, Richard J.

2005-01-01

A postal survey was conducted regarding statistical techniques, research methods and software used in the workplace by 913 graduates with PhD and Masters degrees in the biological sciences, psychology, business, economics, and statistics. The study identified gaps between topics and techniques learned at university and those used in the workplace,…

Sudhir Srivastava, PhD, MPH | Division of Cancer Prevention

Cancer.gov

Dr. Sudhir Srivastava has been Chief of the Cancer Biomarkers Research Group since 2000. His efforts focus on molecular biology of malignancies, early malignancies, risk assessment, and informatics, providing leadership in the areas of molecular screening and early detection. He is one of the principal authors of the Bethesda Guidelines for diagnosing Hereditary non-polyposis

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

Our group is interested in developing novel epigenetic therapeutics for thoracic malignancies, especially small cell lung cancer. The successful candidate will perform studies to develop an effective drug combo from bench to bedside.  The candidate should have a PhD in Molecular Biology, Biochemistry or related disciplines.  The candidate will work with both cell models and

Cloning of the poly(ADP-ribose) Gene from Rat Liver.

DTIC Science & Technology

1986-09-24

Levinson, Ph.D. (Cetus Corp., Berkeley). 5. Amino acid analysis done in UCSF Bioanal. Lab. TABLE OF CONTENTS Page METHOD I...TABLE I ............. ............................... ... 12 Proteolytic degradation, isolation of peptide and amino acid sequences...technique developed for enzyme quantitation in biological materials. The amino- acid sequence of the enzyme has so far been determined because the amino

Monomeric CH3: A Small, Stable Antibody Domain with Therapeutic Promise | Poster

Cancer.gov

By Ashley DeVine, Staff Writer Antibody domains are emerging as promising biopharmaceuticals because of their relatively small size compared to full-sized antibodies, which are too large to effectively penetrate tumors and bind to sterically restricted therapeutic targets. In an article published in The Journal of Biological Chemistry, Tianlei Ying, Ph.D., Dimiter Dimitrov,

On Blue Tongues, Undergraduates, and Science: An Interview With Linda M. Bartoshuk

ERIC Educational Resources Information Center

King, Camille Tessitore

2004-01-01

Camille Tessitore King is an Assistant Professor in the Department of Psychology at Stetson University in DeLand, Florida, where she teaches Introduction to Psychology, Great Experiments in Psychology, Biological Psychology, as well as other advanced topic courses such as Drugs and Behavior. She received her BA, MA, and PhD from the University of…

Quantitative diagnostic method for biceps long head tendinitis by using ultrasound.

PubMed

Huang, Shih-Wei; Wang, Wei-Te

2013-01-01

To investigate the feasibility of grayscale quantitative diagnostic method for biceps tendinitis and determine the cut-off points of a quantitative biceps ultrasound (US) method to diagnose biceps tendinitis. Design. Prospective cross-sectional case controlled study. Outpatient rehabilitation service. A total of 336 shoulder pain patients with suspected biceps tendinitis were recruited in this prospective observational study. The grayscale pixel data of the range of interest (ROI) were obtained for both the transverse and longitudinal views of the biceps US. A total of 136 patients were classified with biceps tendinitis, and 200 patients were classified as not having biceps tendinitis based on the diagnostic criteria. Based on the Youden index, the cut-off points were determined as 26.85 for the transverse view and 21.25 for the longitudinal view of the standard deviation (StdDev) of the ROI values, respectively. When the ROI evaluation of the US surpassed the cut-off point, the sensitivity was 68% and the specificity was 90% in the StdDev of the transverse view, and the sensitivity was 81% and the specificity was 73% in the StdDev of the longitudinal view to diagnose biceps tendinitis. For equivocal cases or inexperienced sonographers, our study provides a more objective method for diagnosing biceps tendinitis in shoulder pain patients.

Early-career researchers: an interview with Paloma Gonzalez Bellido.

PubMed

2017-12-01

Paloma Gonzalez Bellido is a Lecturer in the Department of Physiology, Development and Neuroscience at the University of Cambridge, where she investigates insect vision. She received her Bachelor's degree in Marine Biology from the University of Queensland, Australia, before moving to the University of Sheffield for her PhD with Mikko Juusola, which she completed in 2009. Paloma has been awarded a Cozzarelli Prize and her research has been recognised by the Society for Neuroethology and the Society for Experimental Biology. © 2017. Published by The Company of Biologists Ltd.

Prevalence, sources, and predictors of soy consumption in breast cancer

PubMed Central

Lammersfeld, Carolyn A; King, Jessica; Walker, Sharon; Vashi, Pankaj G; Grutsch, James F; Lis, Christopher G; Gupta, Digant

2009-01-01

Background A number of components in soy appear to have anticancer properties, including the isoflavones, genistein and daidzein. The use of soy by women with breast cancer is now being questioned because of the estrogen-like effects of isoflavones and possible interactions with tamoxifen. Clinicians providing nutrition counseling to these women are concerned because the availability of soy foods has increased dramatically in the past few years. The goal of this study was to quantify the intake of isoflavones in women with breast cancer. Methods A cross-sectional study of 100 women with breast cancer treated at Cancer Treatment Centers of America® between 09/03 and 02/04. Each patient completed a soy food frequency questionnaire (FFQ) that was scored by Fred Hutchinson Cancer Research Center. Demographic and clinical predictors of soy intake were evaluated using one-way non-parametric Mann Whitney test and non-parametric spearman's rank correlation. Results Mean age was 50.5 years (std. dev. = 9.4; range 31–70) and mean BMI was 27.3 kg/m2 (std. dev. = 6.75; range 17–59). Genistein and Daidzein consumption was limited to 65 patients with a mean intake of 11.6 mg/day (std. dev. = 21.9; range 0–97.4) and 7.6 mg/day (std. dev. = 14.1; range 0–68.9) respectively. Soy milk (37%) and pills containing soy, isoflavones, or "natural" estrogen (24%) were the two biggest contributors to isoflavone intake. Conclusion Our study suggests that the isoflavone intake of breast cancer patients at our hospital was quite variable. Thirty-five patients reported no soy intake. The mean daily intake of 11.6 mg genistein and 7.4 mg daidzein, is the equivalent of less than 1/4 cup of tofu per day. This amount is higher than what has been previously reported in non-Asian American women. PMID:19159489

Analysing inter-relationships among water, governance, human development variables in developing countries: WatSan4Dev database coherency analysis

NASA Astrophysics Data System (ADS)

Dondeynaz, C.; Carmona Moreno, C.; Céspedes Lorente, J. J.

2012-01-01

The "Integrated Water Resources Management" principle was formally laid down at the International Conference on Water and Sustainable development in Dublin 1992. One of the main results of this conference is that improving Water and Sanitation Services (WSS), being a complex and interdisciplinary issue, passes through collaboration and coordination of different sectors (environment, health, economic activities, governance, and international cooperation). These sectors influence or are influenced by the access to WSS. The understanding of these interrelations appears as crucial for decision makers in the water sector. In this framework, the Joint Research Centre (JRC) of the European Commission (EC) has developed a new database (WatSan4Dev database) containing 45 indicators (called variables in this paper) from environmental, socio-economic, governance and financial aid flows data in developing countries. This paper describes the development of the WatSan4Dev dataset, the statistical processes needed to improve the data quality; and, finally, the analysis to verify the database coherence is presented. At the light of the first analysis, WatSan4Dev Dataset shows the coherency among the different variables that are confirmed by the direct field experience and/or the scientific literature in the domain. Preliminary analysis of the relationships indicates that the informal urbanisation development is an important factor influencing negatively the percentage of the population having access to WSS. Health, and in particular children health, benefits from the improvement of WSS. Efficient environmental governance is also an important factor for providing improved water supply services. The database would be at the base of posterior analyses to better understand the interrelationships between the different indicators associated in the water sector in developing countries. A data model using the different indicators will be realised on the next phase of this research work.

Identification of a spliced gene from duck enteritis virus encoding a protein homologous to UL15 of herpes simplex virus 1.

PubMed

Zhu, Hongwei; Li, Huixin; Han, Zongxi; Shao, Yuhao; Wang, Yu; Kong, Xiangang

2011-04-06

In herpesviruses, UL15 homologue is a subunit of terminase complex responsible for cleavage and packaging of the viral genome into pre-assembled capsids. However, for duck enteritis virus (DEV), the causative agent of duck viral enteritis (DVE), the genomic sequence was not completely determined until most recently. There is limited information of this putative spliced gene and its encoding protein. DEV UL15 consists of two exons with a 3.5 kilobases (kb) inron and transcribes into two transcripts: the full-length UL15 and an N-terminally truncated UL15.5. The 2.9 kb UL15 transcript encodes a protein of 739 amino acids with an approximate molecular mass of 82 kiloDaltons (kDa), whereas the UL15.5 transcript is 1.3 kb in length, containing a putative 888 base pairs (bp) ORF that encodes a 32 kDa product. We also demonstrated that UL15 gene belonged to the late kinetic class as its expression was sensitive to cycloheximide and phosphonoacetic acid. UL15 is highly conserved within the Herpesviridae, and contains Walker A and B motifs homologous to the catalytic subunit of the bacteriophage terminase as revealed by sequence analysis. Phylogenetic tree constructed with the amino acid sequences of 23 herpesvirus UL15 homologues suggests a close relationship of DEV to the Mardivirus genus within the Alphaherpesvirinae. Further, the UL15 and UL15.5 proteins can be detected in the infected cell lysate but not in the sucrose density gradient-purified virion when reacting with the antiserum against UL15. Within the CEF cells, the UL15 and/or UL15.5 localize(s) in the cytoplasm at 6 h post infection (h p. i.) and mainly in the nucleus at 12 h p. i. and at 24 h p. i., while accumulate(s) in the cytoplasm in the absence of any other viral protein. DEV UL15 is a spliced gene that encodes two products encoded by 2.9 and 1.3 kb transcripts respectively. The UL15 is expressed late during infection. The coding sequences of DEV UL15 are very similar to those of alphaherpesviruses and most similar to the genus Mardivirus. The UL15 and/or UL15.5 accumulate(s) in the cytoplasm during early times post-infection and then are translocated to the nucleus at late times.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartlett, Roscoe A.; Baird, Mark L.; Berrill, Mark A.

This guide describes the structure and setup of the standard VERA development environment (VERA Dev Env) and standard VERA Third Party Libraries (TPLs) that need to be in place before installing many of the VERA simulation components. It describes everything from the initial setup on a new machine to the final build, testing, and installation of VERA components. The goal of this document is to describe how to create the directories and contents outlined in Standard VERA Dev Env Directory Structure and then obtain the remaining VERA source and build, test, and install any of the necessary VERA components onmore » a given system. This document describes the process both for a development version of VERA and for a released tarball of the VERA sources.« less

Update on Development of 360V, 28kWh Lithium-Ion Battery

NASA Technical Reports Server (NTRS)

Davies, Francis; Darcy, Eric; Cowles, Phil; Irlbeck, Brad; Weintritt, John

2005-01-01

Engineering unit submodule batteries (EUSB) the 360V, 28kWh EAPU battery were designed and assembled by COM DEV. These submodules consist of Sony Li-Ion 18650HC cells in a 5P-41S array yielding 180V, 1.4 kWh. Tests of these and of substrings and single cells at COM DEV and at JSC under various performance and abuse conditions demonstrated that performance requirements can be met. The thermal vacuum tests demonstrated that the worst case hot condition is the design driver. Deficiencies in the initial diode protection scheme of the battery were identified as a result of test failures. Potential solutions to the scheme are under development and will be presented.

Science Information Requirements of Scientists: The Need for an Interacting Request Receiver in an Information Clearinghouse, Technical Report 3.

ERIC Educational Resources Information Center

Kinkade, Robert G.; Bedarf, Erwin W.

Evaluated were the role and importance of request-receiver feedback in an information system. Participants were 50 university biological scientists who agreed to place requests for information by telephone with a specially established clearinghouse. One type of receiver was a scientist holding a Ph.D. in biochemistry, with over 20 years biological…

Mark Miller, PhD | Division of Cancer Prevention

Cancer.gov

Dr. Mark Miller joined DCP's Chemopreventive Agent Development Research Group from the Wake Forest School of Medicine, where he was a Professor in the Department of Cancer Biology and Director of Graduate Studies. Prior to that, he was an Assistant Professor in the Department of Pathology at the University of Tennessee in Knoxville. He worked for NCI as a Senior Staff Fellow

TYCTWD Programs Strive to Make Science Educational and Fun | Poster

Cancer.gov

By Carolynne Keenan, Contributing Writer Joseph Barchi, Jr, Ph.D., calls teaching “the noblest and most important profession.” So it makes sense that Barchi, senior scientist and head of the Glycoconjugate and NMR Section, Chemical Biology Laboratory, Center for Cancer Research, NCI at Frederick, would encourage his lab to offer a fun, educational program at Take Your Child to

Fear Factor: How Safe Is It to Make Time for Family?

ERIC Educational Resources Information Center

Ward, Kelly; Wolf-Wendel, Lisa

2004-01-01

Biological and tenure clocks have the unfortunate tendency to tick loudly, clearly, and at the same time. The average age at which faculty earn the PhD is thirty-four, putting the tenure decision at about age forty, just when a woman's fertility is in serious decline. As more women enter the academic profession as assistant professors, more of…

Discovery Systems for Manufacturing

DTIC Science & Technology

1994-01-01

Rev. Letters, 68, Number 10, pp 1500-1503, 1992. Karp, Peter D., Hypothesis Formation and Qualitative Reasoning in Molecular Biology, Ph.D. Thesis ...1-4 2.5.1.2 Evaluating Attributes ........................ 2-17 1.21.4 The Simulated Laboratory ..............1-4 2.5.2 Nearest...4-11vs. Conventional Ae Cs R ............... 2-6 4.33 Initialize Simulator ......... ........... 4-112.4.12.1 Similarities

Neuro-Immune Mechanisms in Response to Venezuelan Equine Encephalitis Virus Infection

DTIC Science & Technology

2000-01-01

iii ABSTRACT NEURO-IMMUNE MECHANISMS IN RESPONSE TO VENEZUELAN EQUINE ENCEPHALITIS VIRUS INFECTION Major Bruce A. Schoneboom directed by Franziska B...Grieder, DVM, Ph.D., Assistant Professor of Microbiology and Immunology, Molecular and Cellular Biology, and Neuroscience Venezuelan equine ...3. DATES COVERED - 4. TITLE AND SUBTITLE NEURO-IMMUNE MECHANISMS IN RESPONSE TO VENEZUELAN EQUINE ENCEPHALITIS VIRUS INFECTION 5a. CONTRACT

CIDR

Science.gov Websites

Consortium Developed Arrays Infinium Human Drug Core Array The Illumina nfinium DrugDev Consortium array drug target discovery, validation and treatment response. Detailed Information on Array Infinium Human

Race and Gender Differences in Undergraduate Research Mentoring Structures and Research Outcomes.

PubMed

Aikens, Melissa L; Robertson, Melissa M; Sadselia, Sona; Watkins, Keiana; Evans, Mara; Runyon, Christopher R; Eby, Lillian T; Dolan, Erin L

2017-01-01

Participating in undergraduate research with mentorship from faculty may be particularly important for ensuring the persistence of women and minority students in science. Yet many life science undergraduates at research universities are mentored by graduate or postdoctoral researchers (i.e., postgraduates). We surveyed a national sample of undergraduate life science researchers about the mentoring structure of their research experiences and the outcomes they realized from participating in research. We observed two common mentoring structures: an open triad with undergraduate-postgraduate and postgraduate-faculty ties but no undergraduate-faculty tie, and a closed triad with ties among all three members. We found that men and underrepresented minority (URM) students are significantly more likely to report a direct tie to their faculty mentors (closed triad) than women, white, and Asian students. We also determined that mentoring structure was associated with differences in student outcomes. Women's mentoring structures were associated with their lower scientific identity, lower intentions to pursue a science, technology, engineering, and mathematics (STEM) PhD, and lower scholarly productivity. URM students' mentoring structures were associated with higher scientific identity, greater intentions to pursue a STEM PhD, and higher scholarly productivity. Asian students reported lower scientific identity and intentions to pursue a STEM PhD, which were unrelated to their mentoring structures. © 2017 M. L. Aikens et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Extended evolution: A conceptual framework for integrating regulatory networks and niche construction

PubMed Central

Renn, Jürgen

2015-01-01

ABSTRACT This paper introduces a conceptual framework for the evolution of complex systems based on the integration of regulatory network and niche construction theories. It is designed to apply equally to cases of biological, social and cultural evolution. Within the conceptual framework we focus especially on the transformation of complex networks through the linked processes of externalization and internalization of causal factors between regulatory networks and their corresponding niches and argue that these are an important part of evolutionary explanations. This conceptual framework extends previous evolutionary models and focuses on several challenges, such as the path‐dependent nature of evolutionary change, the dynamics of evolutionary innovation and the expansion of inheritance systems. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 565–577, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:26097188

Reducing radiation-induced gastrointestinal toxicity — the role of the PHD/HIF axis

PubMed Central

Olcina, Monica M.; Giaccia, Amato J.

2016-01-01

Radiotherapy is an effective treatment strategy for cancer, but a significant proportion of patients experience radiation-induced toxicity due to damage to normal tissue in the irradiation field. The use of chemical or biological approaches aimed at reducing or preventing normal tissue toxicity induced by radiotherapy is a long-held goal. Hypoxia-inducible factors (HIFs) regulate the production of factors that may protect several cellular compartments affected by radiation-induced toxicity. Pharmacological inhibitors of prolyl hydroxylase domain–containing enzymes (PHDs), which result in stabilization of HIFs, have recently been proposed as a new class of radioprotectors. In this review, radiation-induced toxicity in the gastrointestinal (GI) tract and the main cellular compartments studied in this context will be discussed. The effects of PHD inhibition on GI radioprotection will be described in detail. PMID:27548524

European Solid State Device Research Conference (18th) Held on September 13-16 1988 in Montpellier, France. (ESSDERC 88)

DTIC Science & Technology

1988-09-16

IEEE Trans. Electron Dev., 30, pp 1295 (1983) /2/ K.K. Ng and W.T. Lynch, IEEE Trans. Electron Dev., 34, pp 503 (1987). /3/ P.A. van der Plas, W.C.E...300 20 F Ohm I FRC I 500 170 Ohm INPNICje F 65 F 28 fI Cjc F 100 j 45 I fF hFE I 80 j 80 II IBVEB I 6.5 F 6.5 V BVCE I 6.5 6.5 vI BVCB F 18 I 18 (V I...evaluated include a -Xb RAM, a 1.6GHz universal shift register and an 8 bit DAC with a 1.2ns settling time. A micograph of the DAC is shown in figure 6

Collaborative modeling: the missing piece of distributed simulation

NASA Astrophysics Data System (ADS)

Sarjoughian, Hessam S.; Zeigler, Bernard P.

1999-06-01

The Department of Defense overarching goal of performing distributed simulation by overcoming geographic and time constraints has brought the problem of distributed modeling to the forefront. The High Level Architecture standard is primarily intended for simulation interoperability. However, as indicated, the existence of a distributed modeling infrastructure plays a fundamental and central role in supporting the development of distributed simulations. In this paper, we describe some fundamental distributed modeling concepts and their implications for constructing successful distributed simulations. In addition, we discuss the Collaborative DEVS Modeling environment that has been devised to enable graphically dispersed modelers to collaborate and synthesize modular and hierarchical models. We provide an actual example of the use of Collaborative DEVS Modeler in application to a project involving corporate partners developing an HLA-compliant distributed simulation exercise.

The Proposed Doppler Electron Velocimeter and the Need for Nanoscale Dynamics

DOE PAGES

Reu, Phillip L.

2007-05-01

As engineering challenges grow in the ever-shrinking world of nano-design, methods of making dynamic measurements of nano-materials and systems become more important. The Doppler electron velocimeter (DEV) is a new measurement concept motivated by the increasing importance of nano-dynamics. Nano-dynamics is defined in this context as any phenomenon that causes a dynamically changing phase in an electron beam, and includes traditional mechanical motion, as well as additional phenomena including changing magnetic and electric fields. The DEV is only a theoretical device at this point. Lastly, this article highlights the importance of pursuing nano-dynamics and presents a case that the electronmore » microscope and its associated optics are a viable test bed to develop this new measurement tool.« less

Oscar Riddle's Science, a Special Bird, & the Founding of the NABT

ERIC Educational Resources Information Center

Vandervoort, Frances S.

2013-01-01

Oscar Riddle, born in Indiana in 1877, was an ardent evolutionist and a key player in the founding of the National Association of Biology Teachers in 1938. He studied heredity and behavior in domestic pigeons and doves with Charles O. Whitman of the University of Chicago, received his Ph.D. in zoology in 1907, and in 1912 began a long career at…

Summer Prostate Cancer Research Training Program

DTIC Science & Technology

2017-09-01

Biology, and Human Toxicology Graduate Programs. Michael Henry, PhD; Associate Professor, Department of Physiology & Biophysics (319-335- 7886) http...addition, PSA has also been demonstrated to be antigenic and capable of inducing specific immune responses in both humans and mice. However, up to...for animal immunization. Both BCG and Ad microbes have been demonstrated to be safe and effective for antigen delivery in humans and mice. Since

Hunting for the Signatures of Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giorgi, Elena Edi

2016-04-26

This prompts the ambitious question: can we find common mutations across individuals with the same cancer? And how many of these mutational patterns that are common across individuals can we attribute to particular exposures or biological processes? Distinguished postdoctoral researcher Ludmil Alexandrov, from the Los Alamos National Laboratory, has been working on this problem since his he was a PhD student at the Wellcome Trust Sanger Institute.

TYCTWD Programs Strive to Make Science Educational and Fun | Poster

Cancer.gov

By Carolynne Keenan, Contributing Writer Joseph Barchi, Jr, Ph.D., calls teaching “the noblest and most important profession.” So it makes sense that Barchi, senior scientist and head of the Glycoconjugate and NMR Section, Chemical Biology Laboratory, Center for Cancer Research, NCI at Frederick, would encourage his lab to offer a fun, educational program at Take Your Child to Work Day (TYCTWD).

Tumors Induce Complex DNA Damage in Distant Proliferative Tissues in Vivo | Center for Cancer Research

Cancer.gov

In radiation biology, a bystander effect occurs when cells not directly exposed to ionizing radiation show increased genomic instability and impaired viability due to the release of signaling molecules by the irradiated cells in their vicinity. Christophe Redon, Ph.D., and colleagues in CCR’s Laboratory of Molecular Pharmacology, decided to ask whether a tumor itself could

Neuro-Immune Mechanisms in Response to Venezuelan equine encephalitis Virus Infection

DTIC Science & Technology

2000-05-01

horses . They were subsequently shown to be previously unrecognized viral agents of severe equine encephalitis (Smith et al., 1997). One member of...iii ABSTRACT NEURO-IMMUNE MECHANISMS IN RESPONSE TO VENEZUELAN EQUINE ENCEPHALITIS VIRUS INFECTION Major Bruce A. Schoneboom directed by Franziska B...Grieder, DVM, Ph.D., Assistant Professor of Microbiology and Immunology, Molecular and Cellular Biology, and Neuroscience Venezuelan equine

Cultural influences on children's understanding of the human body and the concept of life.

PubMed

Panagiotaki, Georgia; Nobes, Gavin

2014-09-01

This study aimed to identify the age by which children begin to demonstrate a biological understanding of the human body and the idea that the purpose of body functioning is to maintain life. The study also explored the influence of education, culturally specific experiences and religion on knowledge acquisition in this domain. Children aged between 4 and 7 years from three different cultural backgrounds (White British, British Muslim, and Pakistani Muslim) were interviewed about the human body and its functioning. At least half of the 4- to 5-year-olds in each cultural group, and almost all 6- to 7-year-olds, referred to the maintenance of life when explaining organs' functions and so were classified as 'life theorizers'. Pakistani Muslim children gave fewer biological responses to questions about organs' functions and the purpose of eating and breathing, but referred to life more than their British counterparts. Irrespective of cultural group, older children understood organ location and function better than younger children. These findings support Jaakkola and Slaughter's (2002, Br. J. Dev. Psychol., 20, 325) view that children's understanding of the body as a 'life machine' emerges around the ages of 4-5 years. They also suggest that, despite many similarities in children's ideas cross-culturally, different educational input and culturally specific experiences influence aspects of their biological understanding. © 2014 The British Psychological Society.

A Novel Phenanthrene Dioxygenase from Nocardioides sp. Strain KP7: Expression in Escherichia coli

PubMed Central

Saito, Atsushi; Iwabuchi, Tokuro; Harayama, Shigeaki

2000-01-01

Nocardioides sp. strain KP7 grows on phenanthrene but not on naphthalene. This organism degrades phenanthrene via 1-hydroxy-2-naphthoate, o-phthalate, and protocatechuate. The genes responsible for the degradation of phenanthrene to o-phthalate (phd) were found by Southern hybridization to reside on the chromosome. A 10.6-kb DNA fragment containing eight phd genes was cloned and sequenced. The phdA, phdB, phdC, and phdD genes, which encode the α and β subunits of the oxygenase component, a ferredoxin, and a ferredoxin reductase, respectively, of phenanthrene dioxygenase were identified. The gene cluster, phdAB, was located 8.3 kb downstream of the previously characterized phdK gene, which encodes 2-carboxybenzaldehyde dehydrogenase. The phdCD gene cluster was located 2.9 kb downstream of the phdB gene. PhdA and PhdB exhibited moderate (less than 60%) sequence identity to the α and β subunits of other ring-hydroxylating dioxygenases. The PhdC sequence showed features of a [3Fe-4S] or [4Fe-4S] type of ferredoxin, not of the [2Fe-2S] type of ferredoxin that has been found in most of the reported ring-hydroxylating dioxygenases. PhdD also showed moderate (less than 40%) sequence identity to known reductases. The phdABCD genes were expressed poorly in Escherichia coli, even when placed under the control of strong promoters. The introduction of a Shine-Dalgarno sequence upstream of each initiation codon of the phdABCD genes improved their expression in E. coli. E. coli cells carrying phdBCD or phdACD exhibited no phenanthrene-degrading activity, and those carrying phdABD or phdABC exhibited phenanthrene-degrading activity which was significantly less than that in cells carrying the phdABCD genes. It was thus concluded that all of the phdABCD genes are necessary for the efficient expression of phenanthrene-degrading activity. The genetic organization of the phd genes, the phylogenetically diverged positions of these genes, and an unusual type of ferredoxin component suggest phenanthrene dioxygenase in Nocardioides sp. strain KP7 to be a new class of aromatic ring-hydroxylating dioxygenases. PMID:10735855

Splicing Modulation as a Potential Treatment for Vemurafenib-Resistant Melanoma | Center for Cancer Research

Cancer.gov

Over half of melanomas contain mutations in the serine/threonine kinase BRAF. The most common mutation, BRAF(V600E), leads to excessive activation of the MAPK proliferation pathway. Vemurafenib is a potent kinase inhibitor with remarkable clinical activity in BRAF(V600E)-positive melanoma tumors. Patients initially respond to treatment with vemurafenib, but inevitably develop resistance. One known resistance mechanism is aberrant splicing of the BRAF RNA. To understand the molecule mechanism of BRAF mis-splicing, Tom Misteli, Ph.D., and Maayan Salton, Ph.D., of CCR’s Laboratory of Receptor Biology and Gene Expression, and NCI colleagues set out on a molecular investigation to identify the mechanism behind generation of the vemurafenib-resistant BRAF isoforms. Their results led to insight into the molecular mechanism of BRAF splicing in vemurafenib resistance and point to splicing inhibitors as a novel therapeutic strategy to overcome vemurafenib resistance.

NCCU/BBRI-Duke/Urology Partnership in Prostate Cancer Research

DTIC Science & Technology

2008-06-01

Somnath Muhopadhyay, Ph.D.; Joellen Schildkraut, Ph.D.; David Tulis , Ph.D.; Leon Sun, Ph.D.; Lee Jones, Ph.D.; Phillip 5e. TASK NUMBER Febbo, Ph.D...Community-Based Intervention Investigators: Dave Tulis Ph.D., NCCU/BBRI Collaborators: Catherine Hoyo, PhD; Lee Jones, PhD; Stephen Freeland...addition, Dr. David Tulis (NCCU PI) who was working on the exercise project with Dr. Lee Jones (Duke PI), has recently accepted a position at East Carolina

Prospective identification of parasitic sequences in phage display screens

PubMed Central

Matochko, Wadim L.; Cory Li, S.; Tang, Sindy K.Y.; Derda, Ratmir

2014-01-01

Phage display empowered the development of proteins with new function and ligands for clinically relevant targets. In this report, we use next-generation sequencing to analyze phage-displayed libraries and uncover a strong bias induced by amplification preferences of phage in bacteria. This bias favors fast-growing sequences that collectively constitute <0.01% of the available diversity. Specifically, a library of 109 random 7-mer peptides (Ph.D.-7) includes a few thousand sequences that grow quickly (the ‘parasites’), which are the sequences that are typically identified in phage display screens published to date. A similar collapse was observed in other libraries. Using Illumina and Ion Torrent sequencing and multiple biological replicates of amplification of Ph.D.-7 library, we identified a focused population of 770 ‘parasites’. In all, 197 sequences from this population have been identified in literature reports that used Ph.D.-7 library. Many of these enriched sequences have confirmed function (e.g. target binding capacity). The bias in the literature, thus, can be viewed as a selection with two different selection pressures: (i) target-binding selection, and (ii) amplification-induced selection. Enrichment of parasitic sequences could be minimized if amplification bias is removed. Here, we demonstrate that emulsion amplification in libraries of ∼106 diverse clones prevents the biased selection of parasitic clones. PMID:24217917

Genetics Home Reference: Fukuyama congenital muscular dystrophy

MedlinePlus

... Fujii T, Aiba H, Toda T. Seizure-genotype relationship in Fukuyama-type congenital muscular dystrophy. Brain Dev. ... for Links Data Files & API Site Map Subscribe Customer Support USA.gov Copyright Privacy Accessibility FOIA Viewers & ...

Genetics Home Reference: CHOPS syndrome

MedlinePlus

... complex (SEC) and MLL in development and disease. Genes Dev. 2011 Apr 1;25(7):661-72. doi: 10.1101/gad.2015411. Review. Citation ... are genome editing and CRISPR-Cas9? What is precision medicine? What ...

Methodology for the placement of maintenance area headquarters.

DOT National Transportation Integrated Search

1985-01-01

A methodology for strategically locating Virginia Department of Highways and Transportation maintenance area headquarters throughout the state was developed and pilot tested in the Charlottesville Residency (Albemarle and Greene counties). In the dev...

Genetics Home Reference: Smith-Magenis syndrome

MedlinePlus

... segment most often includes approximately 3.7 million DNA building blocks (base pairs), also written as 3. ... AM, Lupski JR, Potocki L. Cognitive and adaptive behavior profiles in Smith-Magenis syndrome. J Dev Behav ...

75 FR 57953 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... announcement of the meeting was practicable. PLACE: Marriner S. Eccles Federal Reserve Board Building, 20th and... about the meeting. Board of Governors of the Federal Reserve System, September 21, 2010. Robert deV...

The influence of self-assembling supramolecular structures on the passive membrane transport of ion-paired molecules.

PubMed

Benaouda, F; Brown, M B; Shah, B; Martin, G P; Jones, S A

2012-12-15

Weak ion-ion interactions, such as those associated with ion-pair formation, are difficult to isolate and characterise in the liquid state, but they have the potential to alter significantly the physicochemical behaviour of molecules in solution. The aim of this work was to gain a better understanding of how ion-ion interactions influenced passive membrane transport. The test system was composed of propylene (PG) glycol, water and diclofenac diethylamine (DDEA). Infrared spectroscopy was employed to determine the nature of the DDEA ion-pair interactions and the drug-vehicle association. Passive transport was assessed using homogeneous synthetic membranes. Solution-state analysis demonstrated that the ion-pair was unperturbed by vehicle composition changes, but the solvent-DDEA interactions were modified. DDEA-PG/water hydrogen bonding influenced the ion-pair solubility (X(dev)) and the solvent interactions slowed transport rate in PG-rich vehicles (0.84±0.05 μg cm(-2) h(-1), at ln(X(dev))=0.57). In water-rich co-solvents, the presence of strong water structuring facilitated a significant increase (p<0.05) in transmembrane penetration rate (e.g. 4.33±0.92 μg cm(-2) h(-1), at ln(X(dev))=-0.13). The data demonstrates that weak ion-ion interactions can result in the embedding of polar entities within a stable solvent complex and spontaneous supramolecular assembly should be considered when interpreting transmembrane transport processes of ionic molecules. Copyright © 2012 Elsevier B.V. All rights reserved.

Duck virus enteritis (duck plague) - a comprehensive update.

PubMed

Dhama, Kuldeep; Kumar, Naveen; Saminathan, Mani; Tiwari, Ruchi; Karthik, Kumaragurubaran; Kumar, M Asok; Palanivelu, M; Shabbir, Muhammad Zubair; Malik, Yashpal Singh; Singh, Raj Kumar

2017-12-01

Duck virus enteritis (DVE), also called duck plague, is one of the major contagious and fatal diseases of ducks, geese and swan. It is caused by duck enteritis virus (DEV)/Anatid herpesvirus-1 of the genus Mardivirus, family Herpesviridae, and subfamily Alpha-herpesvirinae. Of note, DVE has worldwide distribution, wherein migratory waterfowl plays a crucial role in its transmission within and between continents. Furthermore, horizontal and/ or vertical transmission plays a significant role in disease spread through oral-fecal discharges. Either of sexes from varying age groups of ducks is vulnerable to DVE. The disease is characterized by sudden death, vascular damage and subsequent internal hemorrhage, lesions in lymphoid organs, digestive mucosal eruptions, severe diarrhea and degenerative lesions in parenchymatous organs. Huge economic losses are connected with acute nature of the disease, increased morbidity and mortality (5%-100%), condemnations of carcasses, decreased egg production and hatchability. Although clinical manifestations and histopathology can provide preliminary diagnosis, the confirmatory diagnosis involves virus isolation and detection using serological and molecular tests. For prophylaxis, both live-attenuated and killed vaccines are being used in broiler and breeder ducks above 2 weeks of age. Since DEV is capable of becoming latent as well as shed intermittently, recombinant subunit and DNA vaccines either alone or in combination (polyvalent) are being targeted for its benign prevention. This review describes DEV, epidemiology, transmission, the disease (DVE), pathogenesis, and advances in diagnosis, vaccination and antiviral agents/therapies along with appropriate prevention and control strategies.

Notable Expressions: Transcriptional Regulation from Biochemistry to Immunology | Center for Cancer Research

Cancer.gov

Dinah Singer, Ph.D., came to NCI in 1975 as a Postdoctoral Fellow in the Laboratory of Biochemistry, but soon created a career for herself in the Experimental Immunology Branch. Her interest in how genes are regulated to control biological function led her to focus on major histocompatibility complex class I genes (MHC Class I)—molecules critical to immune system function—as a

Yeast Studies Lead to a New DNA-Based Model for Research on Development | Poster

Cancer.gov

A paper from Amar J. S. Klar, Ph.D., with the RNA Biology Laboratory in NCI’s Center for Cancer Research, has identified a model for DNA research that explains the congenital disorder of mirror hand movements in humans. A mirror movement is when an intentional movement on one side of the body is mirrored by an involuntary movement on the other.

Novel Genetic Tools to Accelerate Our Understanding of Photosynthesis and Lipid Accumulation

DTIC Science & Technology

2014-08-20

understanding of photosynthesis and lipid accumulation Martin C. Jonikas, Ph.D. Carnegie Institution for Science, Department of Plant Biology 260...knowledge of algal lipid metabolism and photosynthesis . Advances in our basic understanding of these processes will facilitate genetic engineering of...algae to improve lipid yields. Currently, one of the greatest roadblocks in the study of algal photosynthesis and lipid metabolism is the slow pace of

Radio Frequency Controlled Stimulation of Intracellular Gold or Silver Nanoparticle Conjugates for Use as Potential Sensors or Modulators of Biological Function

DTIC Science & Technology

2010-09-01

SIGNED//___________ DAVID R. MATTIE , PhD, DR-III...RESPONSIBLE PERSON David R. Mattie a. REPORT U b. ABSTRACT U c. THIS PAGE U SAR 72 19b. TELEPHONE...used as a cellular model to determine the interaction of NPs with human skin. HaCaT cells were donated generously by Dr. James F. Dillman III, of the

Syndromic Surveillance and Outbreak Detection Using Automated Microbiologic Laboratory Test Order Data

DTIC Science & Technology

2007-06-15

Laboratory Test Order Data" Ph.D. Degrees Interdisciplinary -Emerging Infectious Diseases -Molecular & Cell Biology -Neuroscience Departmental...for surveillance even though I was unable to attend his workshop. J.D. Malone’s tremendous knowledge of both infectious diseases and the DoD...can reduce morbidity and mortality. The course of many infectious diseases includes a nonspecific prodrome in which symptoms of the disease may be

The Regenerative Response of Endogenous Neural Stem/Progenitor Cells to Traumatic Brain Injury

DTIC Science & Technology

2014-06-09

Genevieve M. Sullivan, Molecular and Cell Biology. 2014 Thesis directed by: Dr. Regina C. Armstrong, PhD, APG The complex pathological mechanisms ...treatments for TBI (83 ). Therefore it is necessary to investigate the complex pathological and molecular mechanisms that occur after heterogeneous...of cellular mechanisms that is not an option in other species with gyrencephalic brains. Therefore, even though a mouse model cannot fully replicate

Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

PubMed Central

Liu, Qingdu; Binns, Thomas C.; Davidoff, Olena; Kapitsinou, Pinelopi P.; Pfaff, Andrew S.; Olauson, Hannes; Fogo, Agnes B.; Fong, Guo-Hua; Gross, Kenneth W.

2016-01-01

Renal peritubular interstitial fibroblast-like cells are critical for adult erythropoiesis, as they are the main source of erythropoietin (EPO). Hypoxia-inducible factor 2 (HIF-2) controls EPO synthesis in the kidney and liver and is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3, which function as cellular oxygen sensors. Renal interstitial cells with EPO-producing capacity are poorly characterized, and the role of the PHD/HIF-2 axis in renal EPO-producing cell (REPC) plasticity is unclear. Here we targeted the PHD/HIF-2/EPO axis in FOXD1 stroma-derived renal interstitial cells and examined the role of individual PHDs in REPC pool size regulation and renal EPO output. Renal interstitial cells with EPO-producing capacity were entirely derived from FOXD1-expressing stroma, and Phd2 inactivation alone induced renal Epo in a limited number of renal interstitial cells. EPO induction was submaximal, as hypoxia or pharmacologic PHD inhibition further increased the REPC fraction among Phd2–/– renal interstitial cells. Moreover, Phd1 and Phd3 were differentially expressed in renal interstitium, and heterozygous deficiency for Phd1 and Phd3 increased REPC numbers in Phd2–/– mice. We propose that FOXD1 lineage renal interstitial cells consist of distinct subpopulations that differ in their responsiveness to Phd2 inactivation and thus regulation of HIF-2 activity and EPO production under hypoxia or conditions of pharmacologic or genetic PHD inactivation. PMID:27088801

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

A post-doctoral fellowship is currently available for productive, highly-motivated, and energetic individuals in the Inflammation and Tumorigenesis Section of Dr. Yinling Hu at the NCI-Frederick campus.  A dynamic research environment and outstanding resources are available for enthusiastic individuals.  Requirements include a Ph.D., M.D., or equivalent degree and experience in Immunology, Molecular Biology, and/or Signaling Research. Candidate must have excellent verbal, written communication and organizational skills, and the ability to handle multiple projects simultaneously. The project will be to investigate mechanisms of IKK/NF-kB-involved lung and skin carcinogenesis/cancer biology, tumor initiating cells, and therapy by using mouse genetic modified mouse models.

A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism*

PubMed Central

Arsenault, Patrick R.; Pei, Fei; Lee, Rebecca; Kerestes, Heddy; Percy, Melanie J.; Keith, Brian; Simon, M. Celeste; Lappin, Terence R. J.; Khurana, Tejvir S.; Lee, Frank S.

2013-01-01

The central pathway for controlling red cell mass is the PHD (prolyl hydroxylase domain protein):hypoxia-inducible factor (HIF) pathway. HIF, which is negatively regulated by PHD, activates numerous genes, including ones involved in erythropoiesis, such as the ERYTHROPOIETIN (EPO) gene. Recent studies have implicated PHD2 as the key PHD isoform regulating red cell mass. Studies of humans have identified erythrocytosis-associated, heterozygous point mutations in the PHD2 gene. A key question concerns the mechanism by which human mutations lead to phenotypes. In the present report, we generated and characterized a mouse line in which a P294R knock-in mutation has been introduced into the mouse Phd2 locus to model the first reported human PHD2 mutation (P317R). Phd2P294R/+ mice display a degree of erythrocytosis equivalent to that seen in Phd2+/− mice. The Phd2P294R/+-associated erythrocytosis is reversed in a Hif2a+/−, but not a Hif1a+/− background. Additional studies using various conditional knock-outs of Phd2 reveal that erythrocytosis can be induced by homozygous and heterozygous knock-out of Phd2 in renal cortical interstitial cells using a Pax3-Cre transgene or by homozygous knock-out of Phd2 in hematopoietic progenitors driven by a Vav1-Cre transgene. These studies formally prove that a missense mutation in PHD2 is the cause of the erythrocytosis, show that this occurs through haploinsufficiency, and point to multifactorial control of red cell mass by PHD2. PMID:24121508

Gold Medal Award for Life Achievement in the Science of Psychology: Lynn Nadel.

PubMed

2017-01-01

The American Psychological Foundation (APF) Gold Medal Awards recognize distinguished and engaging records of accomplishment in 4 areas of psychology. The 2017 recipient of the Gold Medal Award for Life Achievement in the Science of Psychology is Lynn Nadel, PhD. Terence M. Keane, PhD, president of the APF, will present the APF Gold Medal Awards at the 125th Annual Convention of the American Psychological Association on August 4, 2017, at 4:00 p.m. Members of the 2017 APF Board of Trustees are Terence M. Keane, PhD, president; Melba J. T. Vasquez, PhD, vice president-interim secretary; Richard C. McCarty, PhD, treasurer; Elisabeth R. Straus, executive vice president-executive director; Camilla Benbow, EdD; Rosie Phillips Bingham, PhD; Connie S. Chan; Arthur C. Evans, Jr., PhD; Linda M. Forrest, PhD; Douglas C. Haldeman, PhD; Anthony W. Jackson, PhD; Archie L. Turner; W. Bruce Walsh, PhD; and Stewart E. Cooper, PhD, APA Board of Directors liaison. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jokilehto, Terhi; Turku Graduate School of Biomedical Sciences, Turku; Hoegel, Heidi

2010-04-15

Cellular oxygen tension is sensed by a family of prolyl hydroxylases (PHD1-3) that regulate the degradation of hypoxia-inducible factors (HIF-1{alpha} and -2{alpha}). The PHD2 isoform is considered as the main downregulator of HIF in normoxia. Our previous results have shown that nuclear translocation of PHD2 associates with poorly differentiated tumor phenotype implying that nuclear PHD2 expression is advantageous for tumor growth. Here we show that a pool of PHD2 is shuttled between the nucleus and the cytoplasm. In line with this, accumulation of wild type PHD2 in the nucleus was detected in human colon adenocarcinomas and in cultured carcinoma cells.more » The PHD2 isoforms showing high nuclear expression increased anchorage-independent carcinoma cell growth. However, retention of PHD2 in the cytoplasm inhibited the anchorage-independent cell growth. A region that inhibits the nuclear localization of PHD2 was identified and the deletion of the region promoted anchorage-independent growth of carcinoma cells. Finally, the cytoplasmic PHD2, as compared with the nuclear PHD2, less efficiently downregulated HIF expression. Forced HIF-1{alpha} or -2{alpha} expression decreased and attenuation of HIF expression increased the anchorage-independent cell growth. However, hydroxylase-inactivating mutations in PHD2 had no effect on cell growth. The data imply that nuclear PHD2 localization promotes malignant cancer phenotype.« less

Effects of private transportation improvements on economic development.

DOT National Transportation Integrated Search

2012-09-01

In this project, we explored opportunities and effects of public-private or private-private partnerships for mobility improvements (incl. alternative fueled shuttles and IT infrastructure) and assessed their effects on local and regional economic dev...

Alcohol ignition interlock service support

DOT National Transportation Integrated Search

1992-12-01

Author's abstract: This Technical Report was produced under Contract No. DTNH22-89-C-07009 for the National Highway Traffic Safety Administration. Under that same contract, a draft set of model specifications for Breath Alcohol Ignition Interlock Dev...

Genetics Home Reference: fragile X syndrome

MedlinePlus

... Citation on PubMed Koukoui SD, Chaudhuri A. Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome. Brain ... GJ, Dictenberg J. The fragile X syndrome: from molecular genetics to neurobiology. Ment Retard Dev Disabil Res Rev. ...

Evaluation of Vehicle Detection Systems for Traffic Signal Operations

DOT National Transportation Integrated Search

2016-10-16

Typical vehicle detection systems used in traffic signal operations are comprised of inductive loop detectors. Because of costs, installation challenges, and operation and maintenance issues, many alternative non-intrusive systems have been dev...

Investigation of sediment suspension technology.

DOT National Transportation Integrated Search

2016-10-01

The goal of the project was to critically review existing literature to access currently available devices, the : identification of areas of improvement for future designs, and the outline of a new-generation cohesive sediment : erosion measuring dev...

The Road to Remarkable: Directed by Vision, Driven by Strength--2010 Five-Year Report of the Policy and Planning Board

ERIC Educational Resources Information Center

American Psychologist, 2011

2011-01-01

The 2010 Policy and Planning Board of the American Psychological Association (APA) was chaired by Elena J. Eisman, EdD. Other members of the board included Gwyneth M. Boodoo, PhD; G. Rita Dudley-Grant, PhD; Beverly Greene, PhD; Christopher W. Loftis, PhD; Michael J. Murphy, PhD; Paul D. Nelson, PhD; Kurt Salzinger, PhD; and Michael Wertheimer,…

The panacea toolbox of a PhD biomedical student.

PubMed

Skaik, Younis

2014-01-01

Doing a PhD (doctor of philosophy) for the sake of contribution to knowledge should give the student an immense enthusiasm through the PhD period. It is the time in one's life that one spends to "hit the nail on the head" in a specific area and topic of interest. A PhD consists mostly of hard work and tenacity; however, luck and genius might also play a little role. You can pass all PhD phases without having both luck and genius. The PhD student should have pre-PhD and PhD toolboxes, which are "sine quibus non" for getting successfully a PhD degree. In this manuscript, the toolboxes of the PhD student are discussed.

Charles L. Brewer Award for Distinguished Teaching of Psychology: Regan A. R. Gurung.

PubMed

2017-01-01

The American Psychological Foundation (APF) Charles L. Brewer Award for Distinguished Teaching of Psychology recognizes exemplary career contributions to the teaching of psychology. The 2017 recipient of the Charles L. Brewer Award for Distinguished Teaching of Psychology is Regan A. R. Gurung, PhD. Terence M. Keane, PhD, president of the APF, will present the APF Charles L. Brewer Award for Distinguished Teaching of Psychology at the 125th Annual Convention of the American Psychological Association on August 4, 2017, at 4:00 p.m. Members of the 2017 APF Board of Trustees are Terence M. Keane, PhD, president; Melba J. T. Vasquez, PhD, vice president/interim secretary; Richard C. McCarty, PhD, treasurer; Elisabeth R. Straus, executive vice president/executive director; Camilla Benbow, EdD; Rosie Phillips Bingham, PhD; Connie S. Chan; Arthur C. Evans, Jr., PhD; Linda M. Forrest, PhD; Douglas C. Haldeman, PhD; Anthony W. Jackson, PhD; Archie L. Turner; W. Bruce Walsh, PhD; and Stewart E. Cooper, PhD, APA Board of Directors liaison. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Alterations in the Local Axonal Environment Influence Target Reinnervation and Neuronal Survival After PostnataI Axotomy

DTIC Science & Technology

2000-06-21

2000 Dissertation directed by: Rosemary C. Borke, Ph.D. Professor Department of Anatomy and Cell Biology Following peripheral nerve injury in adult...augmented at the injury site and the neuromuscular junction (NMJ) following sciatic nerve axotomy. The current work determined that SC apoptosis occurs in...related and location-specific response to peripheral nerve injury . Apoptotic SC were found in two strategic locations for guiding axonal outgrowth during

The Impact of Spirituality on Cardiovascular Reactivity Among African Americans

DTIC Science & Technology

2010-03-16

13 .17 .00 .00 1.00 -.01 .00 1.00 Income L1L2 -1.85 -.08 .45 2.14 .14 .18 -1.07 -.12 . 22 Does R/S Buffer Stress Effects of...synchronization of cortisol rhythm, immune status and psychospiritual profile in metastatic non-small cell lung cancer. In Vivo, 22 (2), 257-262...HEALTH Ph.D. Degrees Interdisciplinary -Emerging Infectious Diseases -Molecular & Cell Biology -Neuroscience Departmental -Clinical Psychology

Brain Biology Machine Initiative (BBMI) at the University of Oregon

DTIC Science & Technology

2008-09-01

opinions and/or findings contained in this report are those of the author( s ) and should not be construed as an official Department of the Army position...NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Richard W. Linton, PhD - PI 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) University of Oregon Eugene, OR 07403 8. PERFORMING ORGANIZATION REPORT

Maintenance of Glucose Homeostasis Through Acetylation of the Metabolic Transcriptional Coactivator PGC1-alpha

DTIC Science & Technology

2011-02-01

University of Madison, Wisconsin. Department of Biomolecular Chemistry . Personnel Supported by this Grant Joseph Rodgers, Ph.D. Yoonjin Lee...Maryland 21205 2 McKusick-Nathans Institute for Genetic Medicine and the Department of Biological Chemistry , Johns Hopkins University School of...energy state of HepG2 cells after incubations of 1 h (Table 1) or 15 min (data not shown). Quercetin, a putative SIRT1-activating flavonoid , also

Family Structure, Psychosocial Factors, and Cardiovascular Risk Factors in the NHLBI CARDIA Study

DTIC Science & Technology

2013-11-21

Sciences In partial fulfillment of the requirements for the degree of Master of Science 2013 UNH’ORMIED SlERVlCES UNIVERSHY OF THE HEAL TH scrnNClES...IF. lEDW ARD HEBERT SCHOOL OF MEDKCJNE GRADUATE PROGRAMS IN nm lBiOMEDICAL SCIENCES AND PUBUC HEAL TH Ph.D. Degrees lnterdisci pl inary...Emerging Infectious Diseases -Molecular & Cell Biology -Neuroscience Departmental -Clinical Psychology -Environmental Health Sciences -Medical

Calibration of controlling input models for pavement management system.

DOT National Transportation Integrated Search

2013-07-01

The Oklahoma Department of Transportation (ODOT) is currently using the Deighton Total Infrastructure Management System (dTIMS) software for pavement management. This system is based on several input models which are computational backbones to dev...

Journal of Transportation and Statistics

DOT National Transportation Integrated Search

2006-01-01

The journal serves the transportation community by increasing the understanding of the role of transportation in society, its function in the economy, and its interactions with the environment. In addition, the JTS provides a forum for the latest dev...

Genetics Home Reference: dyserythropoietic anemia and thrombocytopenia

MedlinePlus

... PubMed Crispino JD. GATA1 in normal and malignant hematopoiesis. Semin Cell Dev Biol. 2005 Feb;16(1): ... GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol. 2005 Feb;25(4):1215- ...

76 FR 39876 - Government in the Sunshine; Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... public, and no earlier announcement of the meeting was practicable. PLACE: Marriner S. Eccles Federal.... Robert deV. Frierson, Deputy Secretary of the Board. [FR Doc. 2011-17221 Filed 7-5-11; 4:15 pm] BILLING...

76 FR 40731 - Government in the Sunshine; Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... public, and no earlier announcement of the meeting was practicable. PLACE: Marriner S. Eccles Federal..., 2011. Robert deV. Frierson, Deputy Secretary of the Board. [FR Doc. 2011-17487 Filed 7-7-11; 4:15 pm...

Suppliers solve processing problems

USDA-ARS?s Scientific Manuscript database

The year's IFT food expo showcased numerous companies and organizations offering solutions to food processing needs and challenges. From small-scale unit operations to commercial-scale equipment lines, exhibitors highlighted both traditional and novel food processing operations fro food product dev...

Status of Advanced Propulsion Technology in Japan

DOT National Transportation Integrated Search

1982-03-01

This report describes the efforts of the Japanese transit industry, which includes manufacturers and transit operators, in the area of advanced propulsion systems for urban rail vehicles. It presents different chopper system designs, new ac drive dev...

imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel.

PubMed

Grapov, Dmitry; Newman, John W

2012-09-01

Interactive modules for Data Exploration and Visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data through a user-friendly interface. Individual modules enables interactive and dynamic analyses of large data by interfacing R's multivariate statistics and highly customizable visualizations with the spreadsheet environment, aiding robust inferences and generating information-rich data visualizations. This tool provides access to multiple comparisons with false discovery correction, hierarchical clustering, principal and independent component analyses, partial least squares regression and discriminant analysis, through an intuitive interface for creating high-quality two- and a three-dimensional visualizations including scatter plot matrices, distribution plots, dendrograms, heat maps, biplots, trellis biplots and correlation networks. Freely available for download at http://sourceforge.net/projects/imdev/. Implemented in R and VBA and supported by Microsoft Excel (2003, 2007 and 2010).

Mapping CMMI Level 2 to Scrum Practices: An Experience Report

NASA Astrophysics Data System (ADS)

Diaz, Jessica; Garbajosa, Juan; Calvo-Manzano, Jose A.

CMMI has been adopted advantageously in large companies for improvements in software quality, budget fulfilling, and customer satisfaction. However SPI strategies based on CMMI-DEV require heavy software development processes and large investments in terms of cost and time that medium/small companies do not deal with. The so-called light software development processes, such as Agile Software Development (ASD), deal with these challenges. ASD welcomes changing requirements and stresses the importance of adaptive planning, simplicity and continuous delivery of valuable software by short time-framed iterations. ASD is becoming convenient in a more and more global, and changing software market. It would be greatly useful to be able to introduce agile methods such as Scrum in compliance with CMMI process model. This paper intends to increase the understanding of the relationship between ASD and CMMI-DEV reporting empirical results that confirm theoretical comparisons between ASD practices and CMMI level2.

Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, Sarah R.; Rodemeyer, Michael; Garfinkel, Michele S.

Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options Sarah R. Carter, Ph.D., J. Craig Venter Institute; Michael Rodemeyer, J.D., University of Virginia; Michele S. Garfinkel, Ph.D., EMBO; Robert M. Friedman, Ph.D., J. Craig Venter Institute In recent years, a range of genetic engineering techniques referred to as “synthetic biology” has significantly expanded the tool kit available to scientists and engineers, providing them with far greater capabilities to engineer organisms than previous techniques allowed. The field of synthetic biology includes the relatively new ability to synthesize long pieces of DNA from chemicals, as well as improved methods formore » genetic manipulation and design of genetic pathways to achieve more precise control of biological systems. These advances will help usher in a new generation of genetically engineered microbes, plants, and animals. The JCVI Policy Center team, along with researchers at the University of Virginia and EMBO, examined how well the current U.S. regulatory system for genetically engineered products will handle the near-term introduction of organisms engineered using synthetic biology. In particular, the focus was on those organisms intended to be used or grown directly in the environment, outside of a contained facility. The study concludes that the U.S. regulatory agencies have adequate legal authority to address most, but not all, potential environmental, health and safety concerns posed by these organisms. Such near-term products are likely to represent incremental changes rather than a marked departure from previous genetically engineered organisms. However, the study also identified two key challenges for the regulatory system, which are detailed in the report. First, USDA’s authority over genetically engineered plants depends on the use of an older engineering technique that is no longer necessary for many applications. The shift to synthetic biology and other newer genetic engineering techniques will leave many engineered plants without any pre-market regulatory review. Second, the number and diversity of engineered microbes for commercial use will increase in the near future, challenging EPA’s resources, expertise, and perhaps authority to regulate them. For each of these challenges, the report sets out a series of options, including an analysis of the advantages and disadvantages of each option from a variety of perspectives, for policy makers to consider. Policy responses will depend on the trade-offs chosen among competing considerations. This report, funded by the Department of Energy with additional funds from the Alfred P. Sloan Foundation, is the result of a two-year process that included interviews, commissioned background papers, discussions, and two workshops that sought input from a wide range of experts, including U.S. federal agency regulators, legal and science policy experts, representatives from the biotechnology indus¬try, and non-governmental organiza¬tions. This cross-section of views informed this report, but the conclusions are solely those of the authors. An Executive Summary, full Report, and background papers are available at: http://www.jcvi.org/cms/research/projects/synthetic-biology-and-the-us-biotechnology-regulatory-system/overview/« less

Applied PhD Research in a Work-Based Environment: An Activity Theory-Based Analysis

ERIC Educational Resources Information Center

Granata, S. N.; Dochy, F.

2016-01-01

Activity theory is used to compare PhD undertaken at university, that is, academic PhD, with PhD performed in collaboration with industry, that is, semi-industrial PhD. The research is divided into a literature review and a case study. Semi-industrial and academic PhD are modelled as activity systems, and differences are highlighted in terms of…

PhD Students' Work Conditions and Study Environment in University- and Industry-Based PhD Programmes

ERIC Educational Resources Information Center

Kolmos, A.; Kofoed, L. B.; Du, X. Y.

2008-01-01

During the last 10 years, new models of funding and training PhD students have been established in Denmark in order to integrate industry into the entire PhD education. Several programmes have been conducted where it is possible to co-finance PhD scholarships or to become an employee as an industrial PhD in a company. An important question is what…

Multimodality Image-Guided HDR/IMRT in Prostate Cancer: Combined Molecular Targeting Using Nanoparticle MR, 3D MRSI, and 11C Acetate PET Imaging

DTIC Science & Technology

2005-08-01

Ph.D. Panos Fatouros, Ph.D. Jerry Hirsch, MSc, PharmD Rhonda Hoyle Kristin Schmidt Dorin Tudor, Ph.D. Jie Liu CONTRACTING ORGANIZATION: Virginia...McClish, Ph.D., Panos Fatouros, Ph.D., Jerry Hirsch, MSc, PharmD, 5e. TASK NUMBER Rhonda Hoyle, Kristin Schmidt, Dorin Tudor, Ph.D., Jie Liu 5f. WORK UNIT

The GenDev Curriculum Development Workshop.

PubMed

D'cunha, J

1997-01-01

This article describes the second Curriculum Development Workshop held in May 1997 at the Asian Institute of Technology (AIT) in Bangkok, Thailand. The workshop aimed to review critically and restructure the Gender and Development Studies (GenDev) curriculum and to assess AIT's role in training gender experts for the region. Participants included 22 people from 16 countries in Asia, Europe, and the US who were teaching graduate students about gender issues and who were activists with nongovernmental organizations working on gender issues. It was determined that the following were required courses: Culture, Knowledge and Gender Relations; Gender, Technology, and Development; Principles of Gender Research and Methodology in Science and Technology; and Gender Analysis and Field Methods. Other suggested core courses included: Gender and Natural Resource Management; Enterprise Management, Technology, and Gender; Gender and Agrarian Reform; Urbanization: A Gender Perspective; Gender-Responsive Development Planning; and Gender and Economic Change: Past and Present Concerns. Participants distinguished between GenDev courses offered to anyone attending AIT and training courses designed to produce gender experts in the region. The aim of training courses for AIT graduate students was to sensitize potential managers, technologists, and others on gender issues and to create awareness of the importance of including gender perspectives within decision-making, policy formation, and implementation. Training courses to produce gender experts should be directed to those with a prior background in gender studies and include gender analysis in field methods. Participants agreed that there should be an independent and autonomous field of gender and development studies. Participants made six recommendations for such a field of study.

Making connections : intermodal links in the public transportation system

DOT National Transportation Integrated Search

2007-09-01

Since at least 1991, federal transportation policy has sought to encourage intermodal connections the links that allow passengers to switch from one mode of public transportation to another. The intermodal terminal is a key building block for dev...

Locomotive crashworthiness research : volume 5 : cab car crashworthiness report

DOT National Transportation Integrated Search

1996-03-01

Models used to analyze locomotive crashworthiness are modified for application to control cab cars of the types used for intercity and commuter rail passenger service. An existing control cab car is analyzed for crashworthiness based on scenarios dev...

Directors of Health Promotion and Education

MedlinePlus

... Dev Career Center DHPE Webinars Systems Change for Health School Employee Wellness CHES/Attendee Certificates Calendar of Events Internships ... Calendar of Events Career Center Policy Briefs School Employee Wellness Links to Other ... of Health Promotion and Education (DHPE) News & Updates more & ...

75 FR 47305 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-05

...: Marriner S. Eccles Federal Reserve Board Building, 20th and C Streets, N.W., Washington, D.C. 20551. STATUS..., 2010. Robert deV. Frierson, Deputy Secretary of the Board. [FR Doc. 2010-19471 Filed 8-3-10; 4:15 pm...

The Volpe National Transportation Systems Center : an introduction

DOT National Transportation Integrated Search

1997-01-01

The Volpe National Transportation Systems Center (Volpe Center) has a long and proud history of defining problems and developing solutions. For more than 25 years, the Center has been applying its unique technical knowledge in planning, research, dev...

Sending the Right Signals | Center for Cancer Research

Cancer.gov

Diffuse large B-cell lymphomas (DLBCL), the most common type of non-Hodgkin’s lymphoma, causes about 10,000 deaths every year in the United States, even though about half of all patients are cured with current regimens. There are different subtypes of DLBCL that vary biologically and have significantly different rates of patient survival following chemotherapy, with the activated B cell-like (ABC) subtype being the least responsive to current therapies. So Louis M. Staudt M.D., Ph.D., Head of the Molecular Biology of Lymphoid Malignancies Section at CCR, and his team set out to find why patients with this subtype have such unfavorable outcomes and how treatment of this disease can be improved.

Identifying Molecular Targets For PTSD Treatment Using Single Prolonged Stress

DTIC Science & Technology

2014-10-01

mRNA levels in the locus coeruleus. Based on our findings we hypothesize that SPS alters glucocorticoid and beta adrenergic receptor (β-AR) expression...recruited to join the project. This individual was a recent graduate from PhD training and came with expertise in animal behavioral tests of anxiety ...peer-reviewed journals (Biology of Mood and Anxiety Disorders, 2013, 3,22; Psychopharmacology, 2014, DOI:10.1007/s00213-014-3635-x). Dr. George has

Award for Distinguished Contributions to the International Advancement of Psychology.

PubMed

2016-11-01

This award is given to individuals who have made sustained and enduring contributions to international cooperation and the advancement of knowledge in psychology. The 2016 recipient of the APA Award for Distinguished Contributions to the International Advancement of Psychology was selected by the 2015 Committee on International Relations in Psychology (CIRP). The members of the 2015 CIRP were Rehman Abdulrehman, PhD (Chair); Gonzalo Bacigalupe, EdD; Silvia S. Canetto, PhD; Amanda Clinton, PhD; Melissa L. Morgan Consoli, PhD; Chryse G. Hatzichristou, PhD; Arpana G. Inman, PhD; Lori Foster Thompson, PhD; and Danny Wedding, PhD. Dr. Abdulrehman, Dr. Morgan Consoli, Dr. Thompson, and Dr. Wedding were members of the subcommittee for the 2016 award. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

PubMed Central

Luo, Weibo; Lin, Benjamin; Wang, Yingfei; Zhong, Jun; O'Meally, Robert; Cole, Robert N.; Pandey, Akhilesh; Levchenko, Andre; Semenza, Gregg L.

2014-01-01

Actin filaments play an essential role in cell movement, and many posttranslational modifications regulate actin filament assembly. Here we report that prolyl hydroxylase 3 (PHD3) interacts with nonmuscle actin in human cells and catalyzes hydroxylation of actin at proline residues 307 and 322. Blocking PHD3 expression or catalytic activity by short hairpin RNA knockdown or pharmacological inhibition, respectively, decreased actin prolyl hydroxylation. PHD3 knockdown increased filamentous F-actin assembly, which was reversed by PHD3 overexpression. PHD3 knockdown increased cell velocity and migration distance. Inhibition of PHD3 prolyl hydroxylase activity by dimethyloxalylglycine also increased actin polymerization and cell migration. These data reveal a novel role for PHD3 as a negative regulator of cell motility through posttranslational modification of nonmuscle actins. PMID:25079693

Guidelines for development of the Iowa statewide transportation improvement program (STIP). Revised.

DOT National Transportation Integrated Search

2004-01-01

The Transportation Equity Act for the 21st Century (TEA-21) continues the Intermodal Surface Transportation Efficiency Act of 1991's requirement for an extensive, ongoing cooperative planning effort for programming federal funding. Iowa's STIP is dev...

Connection details for prefabricated bridge elements and systems.

DOT National Transportation Integrated Search

2009-03-30

Prefabricated components of a bridge produced off-site can be assembled quickly, and can reduce design time and cost, minimizing forming, minimize lane closure time and/or possibly eliminate the need for a temporary bridge. This document has been dev...

SITE PROGRAM EVALUATION OF THE SONOTECH PULSE COMBUSTION BURNER TECHNOLOGY - TECHNICAL RESULTS

EPA Science Inventory

A series of demonstration tests was performed at the Environmental Protection Agency's (EPA's) Incineration Research Facility (IRF) under the Superfund Innovative Technology Evaluation (SITE) program. These tests, twelve in all, evaluated a pulse combustion burner technology dev...

Growing cooler : the evidence on urban development and climate change

DOT National Transportation Integrated Search

1997-10-01

This new book documents how key changes in land development patterns could help reduce vehicle : greenhouse gas emissions. Based on a comprehensive review of dozens of studies by leading urban : planning researchers, the book concludes that urban dev...

DETERMINATION OF ELEMENTAL COMPOSITIONS BY HIGH RESOLUTION MASS SPECTROMETRY WITHOUT MASS CALIBRANTS

EPA Science Inventory

Widely applicable mass calibrants, including perfluorokerosene, are available for gas-phase introduction of analytes ionized by electron impact (EI) prior to analysis using high resolution mass spectrometry. Unfortunately, no all-purpose calibrants are available for recently dev...

Earplug rankings based on the protector-attenuation rating (P-AR).

DOT National Transportation Integrated Search

1975-01-01

Forty-five attenuation spectra for earplugs were classified according to a simplified method designed to produce single-number ratings of noise reduction. The rating procedure was applied to the mean attenuation scores, to mean-minus-one-standard-dev...

Using HexSim to link demography and genetics in animal and plant simulations

EPA Science Inventory

Simulation models are essential for understanding the effects of land management practices and environmental drivers, including landscape change, shape population genetic structure and persistence probabilities. The emerging field of eco-evolutionary modeling is beginning to dev...

Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice.

PubMed

Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Dunna, Nageswara Rao; Zhan, Lijun; Oriowo, Babatunde; Takeda, Kotaro; Sanchez, Juan A; Otani, Hajime; Maulik, Gautam; Fong, Guo-Hua; Maulik, Nilanjana

2011-10-01

Hypoxia-inducible transcription factor (HIF)-prolyl hydroxylases domain (PHD-1-3) are oxygen sensors that regulate the stability of the HIFs in an oxygen-dependent manner. Suppression of PHD enzymes leads to stabilization of HIFs and offers a potential treatment option for many ischemic disorders, such as peripheral artery occlusive disease, myocardial infarction, and stroke. Here, we show that homozygous disruption of PHD-1 (PHD-1(-/-)) could facilitate HIF-1α-mediated cardioprotection in ischemia/reperfused (I/R) myocardium. Wild-type (WT) and PHD-1(-/-) mice were randomized into WT time-matched control (TMC), PHD-1(-/-) TMC (PHD1TMC), WT I/R, and PHD-1(-/-) I/R (PHD1IR). Isolated hearts from each group were subjected to 30 min of global ischemia followed by 2 h of reperfusion. TMC hearts were perfused for 2 h 30 min without ischemia. Decreased infarct size (35%±0.6% vs. 49%±0.4%) and apoptotic cardiomyocytes (106±13 vs. 233±21 counts/100 high-power field) were observed in PHD1IR compared to wild-type ischemia/reperfusion (WTIR). Protein expression of HIF-1α was significantly increased in PHD1IR compared to WTIR. mRNA expression of β-catenin (1.9-fold), endothelial nitric oxide synthase (1.9-fold), p65 (1.9-fold), and Bcl-2 (2.7-fold) were upregulated in the PHD1IR compared with WTIR, which was studied by real-time quantitative polymerase chain reaction. Further, gel-shift analysis showed increased DNA binding activity of HIF-1α and nuclear factor-kappaB in PHD1IR compared to WTIR. In addition, nuclear translocation of β-catenin was increased in PHD1IR compared with WTIR. These findings indicated that silencing of PHD-1 attenuates myocardial I/R injury probably by enhancing HIF-1α/β-catenin/endothelial nitric oxide synthase/nuclear factor-kappaB and Bcl-2 signaling pathway.

densityCut: an efficient and versatile topological approach for automatic clustering of biological data

PubMed Central

Ding, Jiarui; Shah, Sohrab; Condon, Anne

2016-01-01

Motivation: Many biological data processing problems can be formalized as clustering problems to partition data points into sensible and biologically interpretable groups. Results: This article introduces densityCut, a novel density-based clustering algorithm, which is both time- and space-efficient and proceeds as follows: densityCut first roughly estimates the densities of data points from a K-nearest neighbour graph and then refines the densities via a random walk. A cluster consists of points falling into the basin of attraction of an estimated mode of the underlining density function. A post-processing step merges clusters and generates a hierarchical cluster tree. The number of clusters is selected from the most stable clustering in the hierarchical cluster tree. Experimental results on ten synthetic benchmark datasets and two microarray gene expression datasets demonstrate that densityCut performs better than state-of-the-art algorithms for clustering biological datasets. For applications, we focus on the recent cancer mutation clustering and single cell data analyses, namely to cluster variant allele frequencies of somatic mutations to reveal clonal architectures of individual tumours, to cluster single-cell gene expression data to uncover cell population compositions, and to cluster single-cell mass cytometry data to detect communities of cells of the same functional states or types. densityCut performs better than competing algorithms and is scalable to large datasets. Availability and Implementation: Data and the densityCut R package is available from https://bitbucket.org/jerry00/densitycut_dev. Contact: condon@cs.ubc.ca or sshah@bccrc.ca or jiaruid@cs.ubc.ca Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27153661

The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration

PubMed Central

Rentzsch, Fabian; Röttinger, Eric

2016-01-01

Reverse genetics and next‐generation sequencing unlocked a new era in biology. It is now possible to identify an animal(s) with the unique biology most relevant to a particular question and rapidly generate tools to functionally dissect that biology. This review highlights the rise of one such novel model system, the starlet sea anemone Nematostella vectensis. Nematostella is a cnidarian (corals, jellyfish, hydras, sea anemones, etc.) animal that was originally targeted by EvoDevo researchers looking to identify a cnidarian animal to which the development of bilaterians (insects, worms, echinoderms, vertebrates, mollusks, etc.) could be compared. Studies in Nematostella have accomplished this goal and informed our understanding of the evolution of key bilaterian features. However, Nematostella is now going beyond its intended utility with potential as a model to better understand other areas such as regenerative biology, EcoDevo, or stress response. This review intends to highlight key EvoDevo insights from Nematostella that guide our understanding about the evolution of axial patterning mechanisms, mesoderm, and nervous systems in bilaterians, as well as to discuss briefly the potential of Nematostella as a model to better understand the relationship between development and regeneration. Lastly, the sum of research to date in Nematostella has generated a variety of tools that aided the rise of Nematostella to a viable model system. We provide a catalogue of current resources and techniques available to facilitate investigators interested in incorporating Nematostella into their research. WIREs Dev Biol 2016, 5:408–428. doi: 10.1002/wdev.222 For further resources related to this article, please visit the WIREs website. PMID:26894563

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

PubMed Central

Wu, Colleen; Rankin, Erinn B.; Castellini, Laura; Fernandez-Alcudia, Javier; LaGory, Edward L.; Andersen, Rebecca; Rhodes, Steven D.; Wilson, Tremika L.S.; Mohammad, Khalid S.; Castillo, Alesha B.; Guise, Theresa A.; Schipani, Ernestina

2015-01-01

The bone microenvironment is composed of niches that house cells across variable oxygen tensions. However, the contribution of oxygen gradients in regulating bone and blood homeostasis remains unknown. Here, we generated mice with either single or combined genetic inactivation of the critical oxygen-sensing prolyl hydroxylase (PHD) enzymes (PHD1–3) in osteoprogenitors. Hypoxia-inducible factor (HIF) activation associated with Phd2 and Phd3 inactivation drove bone accumulation by modulating osteoblastic/osteoclastic cross-talk through the direct regulation of osteoprotegerin (OPG). In contrast, combined inactivation of Phd1, Phd2, and Phd3 resulted in extreme HIF signaling, leading to polycythemia and excessive bone accumulation by overstimulating angiogenic–osteogenic coupling. We also demonstrate that genetic ablation of Phd2 and Phd3 was sufficient to protect ovariectomized mice against bone loss without disrupting hematopoietic homeostasis. Importantly, we identify OPG as a HIF target gene capable of directing osteoblast-mediated osteoclastogenesis to regulate bone homeostasis. Here, we show that coordinated activation of specific PHD isoforms fine-tunes the osteoblastic response to hypoxia, thereby directing two important aspects of bone physiology: cross-talk between osteoblasts and osteoclasts and angiogenic–osteogenic coupling. PMID:25846796

DEMONSTRATION BULLETIN: TEXACO GASIFICATION PROCESS TEXACO, INC.

EPA Science Inventory

The Texaco Gasification Process (TGP) has operated commercially for nearly 45 years on feeds such as natural gas, liquid petroleum fractions, coal, and petroleum coke. More than 45 plants are either operational or under development in the United States and abroad. Texaco has dev...

Load and resistance factor design of bridge foundations accounting for pile group-soil interaction.

DOT National Transportation Integrated Search

2015-11-01

Pile group foundations are used in most foundation solutions for transportation structures. Rigorous and reliable pile design methods are : required to produce designs whose level of safety (probability of failure) is known. By utilizing recently dev...

A MANAGEMENT SUPPORT SYSTEM FOR GREAT LAKES COASTAL WETLANDS

EPA Science Inventory

The Great Lakes National Program Office in conjunction with the Great Lakes Commission and other researchers is leading a large scale collaborative effort that will yield, in unprecedented detail, a management support system for Great Lakes coastal wetlands. This entails the dev...

Aviation Mechanic General, Airframe, and Powerplant Knowledge Test Guide

DOT National Transportation Integrated Search

1995-01-01

The FAA has available hundreds of computer testing centers nationwide. These testing centers offer the full range of airman knowledge tests. Refer to appendix 1 in this guide for a list of computer testing designees. This knowledge test guide was dev...

Cost-Effectiveness of Aflatoxin Control Methods: Economic Incentives

USDA-ARS?s Scientific Manuscript database

Multiple sectors in U.S. crop industries – growers, elevators, handlers/shellers, processors, distributors, and consumers – are affected by aflatoxin contamination of commodities, and have the potential to control it. Aflatoxin control methods at both preharvest and postharvest levels have been dev...

Publishing scientific papers based on Master's and Ph.D. theses from a small scientific community: case study of Croatian medical schools.

PubMed

Frković, Vedran; Skender, Tomislav; Dojćinović, Bojan; Bilić-Zulle, Lidija

2003-02-01

To evaluate publishing activity of medical doctors after they have obtained Master's or Ph.D. degree at the Rijeka and Zagreb University Schools of Medicine in Croatia, and establish the number of journal articles based on these theses. Data on Master's and Ph.D. theses defended at the Rijeka and Zagreb University Schools of Medicine in the 1990-1999 period were collected by hand-search of the archive. MEDLINE and Current Contents databases were searched for journal articles resulting from the theses. During the 10-year period, 1,535 Master's and 634 Ph.D. theses were defended at the Rijeka and Zagreb University Schools of Medicine (253 Master's and 138 Ph.D. theses from Rijeka and 1,282 Master's and 496 Ph.D. theses from Zagreb). There were 201 (14%) Master's and 218 (34%) Ph.D. theses that resulted in articles published in journals indexed in MEDLINE (13% of Master's and 11% of Ph.D. theses from Rijeka, and 14% of Master's and 41% of Ph.D. theses from Zagreb). Also, 97 (6%) Master's and 129 (20%) Ph.D. theses that resulted in articles published in Current Contents journals (8% of Master's and 6% of Ph.D. theses from Rijeka, and 6% of Master's and 24% of Ph.D. theses from Zagreb). There was no significant difference between the two Universities with respect to published articles based on Master's theses, but there were significantly more articles from Ph.D. theses in Zagreb (p<0.001). Most of the theses resulted in a single publication (95%), 19 (5%) in 2, and 2 in 3 publications. Out of all 453 journal articles, 31% were published in Croatian and 69% in international journals. Most Croatian Master's and Ph.D. theses are not made available to the scientific community. There should be more institutional effort directed at the stimulation of postgraduate students to publish their scientific work.

Psi Chi/APA Edwin B. Newman Graduate Research Award.

PubMed

2016-11-01

The Edwin B. Newman Graduate Research Award is sponsored jointly by Psi Chi, the national honor society in psychology, and the APA. The award is presented annually to the psychology graduate student who submits the best research paper that was published or presented at a national, regional, or state psychological association conference during the past calendar year. The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. Members of the 2016 Edwin B. Newman Award Committee were Shawn Carlton, PhD, Psi Chi representative; Christina Frederick-Recascino, PhD; John Norcross, PhD, APA representative; Karenna Malavanti, PhD, Psi Chi representative; Steven Kohn, PhD, Psi Chi representative; Warren Fass, PhD, Psi Chi representative; Chris Lovelace, PhD, Psi Chi representative; and Cathy Epkins, PhD, APA representative. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

International Humanitarian Award.

PubMed

2016-11-01

The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2016 recipient of the APA International Humanitarian Award was selected by the 2015 Committee on International Relations in Psychology (CIRP). The members of the 2015 CIRP were Rehman Abdulrehman, PhD (Chair); Gonzalo Bacigalupe, EdD; Silvia S. Canetto, PhD; Amanda Clinton, PhD; Melissa L. Morgan Consoli, PhD; Chryse G. Hatzichristou, PhD; Arpana G. Inman, PhD; Lori Foster Thompson, PhD; and Danny Wedding, PhD. Dr. Abdulrehman, Dr. Morgan Consoli, Dr. Thompson, and Dr. Wedding were members of the subcommittee for the 2016 award. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Interaction Gaps in PhD Education and ICT as a Way Forward: Results from a Study in Sweden

ERIC Educational Resources Information Center

Aghaee, Naghmeh; Jobe, William Byron; Karunaratne, Thashmee; Smedberg, Åsa; Hansson, Henrik; Tedre, Matti

2016-01-01

Many research studies have highlighted the low completion rate and slow progress in PhD education. Universities strive to improve throughput and quality in their PhD education programs. In this study, the perceived problems of PhD education are investigated from PhD students' points of view, and how an Information and Communication Technology…

Supporting Collaborative Model and Data Service Development and Deployment with DevOps

NASA Astrophysics Data System (ADS)

David, O.

2016-12-01

Adopting DevOps practices for model service development and deployment enables a community to engage in service-oriented modeling and data management. The Cloud Services Integration Platform (CSIP) developed the last 5 years at Colorado State University provides for collaborative integration of environmental models into scalable model and data services as a micro-services platform with API and deployment infrastructure. Originally developed to support USDA natural resource applications, it proved suitable for a wider range of applications in the environmental modeling domain. While extending its scope and visibility it became apparent community integration and adequate work flow support through the full model development and application cycle drove successful outcomes.DevOps provide best practices, tools, and organizational structures to optimize the transition from model service development to deployment by minimizing the (i) operational burden and (ii) turnaround time for modelers. We have developed and implemented a methodology to fully automate a suite of applications for application lifecycle management, version control, continuous integration, container management, and container scaling to enable model and data service developers in various institutions to collaboratively build, run, deploy, test, and scale services within minutes.To date more than 160 model and data services are available for applications in hydrology (PRMS, Hydrotools, CFA, ESP), water and wind erosion prediction (WEPP, WEPS, RUSLE2), soil quality trends (SCI, STIR), water quality analysis (SWAT-CP, WQM, CFA, AgES-W), stream degradation assessment (SWAT-DEG), hydraulics (cross-section), and grazing management (GRAS). In addition, supporting data services include soil (SSURGO), ecological site (ESIS), climate (CLIGEN, WINDGEN), land management and crop rotations (LMOD), and pesticides (WQM), developed using this workflow automation and decentralized governance.

Evaluating the Hydrologic Performance of Low Impact Development Scenarios in a Micro Urban Catchment.

PubMed

Li, Chunlin; Liu, Miao; Hu, Yuanman; Han, Rongqing; Shi, Tuo; Qu, Xiuqi; Wu, Yilin

2018-02-05

As urbanization progresses, increasingly impervious surfaces have changed the hydrological processes in cities and resulted in a major challenge for urban stormwater control. This study uses the urban stormwater model to evaluate the performance and costs of low impact development (LID) scenarios in a micro urban catchment. Rainfall-runoff data of three rainfall events were used for model calibration and validation. The pre-developed (PreDev) scenario, post-developed (PostDev) scenario, and three LID scenarios were used to evaluate the hydrologic performance of LID measures. Using reduction in annual runoff as the goal, the best solutions for each LID scenario were selected using cost-effectiveness curves. The simulation results indicated that the three designed LID scenarios could effectively reduce annual runoff volumes and pollutant loads compared with the PostDev scenario. The most effective scenario (MaxPerf) reduced annual runoff by 53.4%, followed by the sponge city (SpoPerf, 51.5%) and economy scenarios (EcoPerf, 43.1%). The runoff control efficiency of the MaxPerf and SpoPerf scenarios increased by 23.9% and 19.5%, respectively, when compared with the EcoPerf scenario; however, the costs increased by 104% and 83.6%. The reduction rates of four pollutants (TSS, TN, TP, and COD) under the MaxPerf scenario were 59.8-61.1%, followed by SpoPerf (53.9-58.3%) and EcoPerf (42.3-45.4%), and the costs of the three scenarios were 3.74, 3.47, and 1.83 million yuan, respectively. These results can provide guidance to urban stormwater managers in future urban planning to improve urban water security.

Evaluating the Hydrologic Performance of Low Impact Development Scenarios in a Micro Urban Catchment

PubMed Central

Li, Chunlin; Liu, Miao; Hu, Yuanman; Han, Rongqing; Shi, Tuo; Qu, Xiuqi; Wu, Yilin

2018-01-01

As urbanization progresses, increasingly impervious surfaces have changed the hydrological processes in cities and resulted in a major challenge for urban stormwater control. This study uses the urban stormwater model to evaluate the performance and costs of low impact development (LID) scenarios in a micro urban catchment. Rainfall-runoff data of three rainfall events were used for model calibration and validation. The pre-developed (PreDev) scenario, post-developed (PostDev) scenario, and three LID scenarios were used to evaluate the hydrologic performance of LID measures. Using reduction in annual runoff as the goal, the best solutions for each LID scenario were selected using cost-effectiveness curves. The simulation results indicated that the three designed LID scenarios could effectively reduce annual runoff volumes and pollutant loads compared with the PostDev scenario. The most effective scenario (MaxPerf) reduced annual runoff by 53.4%, followed by the sponge city (SpoPerf, 51.5%) and economy scenarios (EcoPerf, 43.1%). The runoff control efficiency of the MaxPerf and SpoPerf scenarios increased by 23.9% and 19.5%, respectively, when compared with the EcoPerf scenario; however, the costs increased by 104% and 83.6%. The reduction rates of four pollutants (TSS, TN, TP, and COD) under the MaxPerf scenario were 59.8–61.1%, followed by SpoPerf (53.9–58.3%) and EcoPerf (42.3–45.4%), and the costs of the three scenarios were 3.74, 3.47 and 1.83 million yuan, respectively. These results can provide guidance to urban stormwater managers in future urban planning to improve urban water security. PMID:29401747

Contributions to Cancer Research: Finding a Niche in Communication | Office of Cancer Genomics

Cancer.gov

This past July, I started a journey into the fields of communications and cancer research when I joined the Office of Cancer Genomics (OCG) as a fellow in the National Cancer Institute (NCI) Health Communications Internship Program (HCIP). Cancer genomics and working in an office were new and uncharted territory for me: before I came to OCG, I was finishing a Ph.D. in cell biology at Vanderbilt University in Dr. Matthew Tyska’s laboratory.

Tumors Induce Complex DNA Damage in Distant Proliferative Tissues in Vivo | Center for Cancer Research

Cancer.gov

In radiation biology, a bystander effect occurs when cells not directly exposed to ionizing radiation show increased genomic instability and impaired viability due to the release of signaling molecules by the irradiated cells in their vicinity. Christophe Redon, Ph.D., and colleagues in CCR’s Laboratory of Molecular Pharmacology, decided to ask whether a tumor itself could exhibit a similar effect. Their results were recently published in the Proceedings of the National Academy of Sciences.

Test Results of Air-Permeable Charcoal Impregnated Suits to Challenge by Chemical and Biological Warfare Agents and Simulants: Summary Report

DTIC Science & Technology

2002-09-01

Area M ) + 0.4(Thigh Area M ) + 0.05(Upper Arm Seam M ) + 0.05(Lower Leg Seam M ) + 0.1(Crotch Area M ). f f f f f 428 53971 61240 454 24385 ...Public Health, San Antonio, TX • Annetta P. Watson, Ph.D., Life Sciences Div., Oak Ridge National Laboratories, Oak Ridge, TN • Leo F . Saubier...TOMPS) ……………………….. 35 F Giat NBC SWAT Suit

Histologic Evaluation of a Polylactic Acid Confluent Sheet in the Treatment of Osseous Defects,

DTIC Science & Technology

1992-01-01

Cobb, DDS, PhD * John C. Reed, DDS + Caesar E. Solano, DMD + W. Robert Hiatt, DDS + • Departments of Periodontics and Oral Biology, University of...may be employed as a matrix for osseous grafting, for the occlusion of large bony defects, for soft tissue contour defects, and also as a bone plating...trabecular bone. Further, the periosteum regenerated as a confluent layer of fibrous connective tissue covering the superior aspect of the implant material

Integration of Genomic, Biologic, and Chemical Approaches to Target p53 Loss and Gain-of-Function in Triple Negative Breast Cancer

DTIC Science & Technology

2015-09-01

dissertation research is determining the mechanism and “targetability” of a mutant p53-adapted state in triple-negative breast cancer . Tim’s...Negative Breast Cancer PRINCIPAL INVESTIGATOR: Jennifer A. Pietenpol, Ph.D. CONTRACTING ORGANIZATION: The Vanderbilt University Nashville, TN...Loss and Gain-of-Function in Triple Negative Breast Cancer 5a. CONTRACT NUMBER W81XWH-13-1-0287 p53 Loss and Gain-of-Function in Triple Negative

A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer Risk

DTIC Science & Technology

2006-11-01

Wv mice and genetic alterations such as p53, pten, or p27kip1, which are found in human ovarian cancer. 2. Body: Research Progress In the first year...press (Yang et al., Am. J. Pathology 2007). To collaborate with the mouse model study, we have also examined human ovaries obtained from prophylactic...results in the coming years. Xu, Xiangxi, Ph.D. 8 3. Key Research Accomplishments (1) Further verify the relevance of the Wv mouse model to human

Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.

PubMed

Elserafy, Menattallah; Abugable, Arwa A; Atteya, Reham; El-Khamisy, Sherif F

2018-05-25

Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Collaborators | Center for Cancer Research

Cancer.gov

Collaborators Structural Biophysics Laboratory, CCR Macromolecular NMR Section (R. Andrew Byrd, Ph.D.) Protein-Nucleic Acid Interactions Section (Yun-Xing Wang, Ph.D.) Protein Processing Section (Kylie J. Walters, Ph.D.) Kinase Complexes Section (Ping Zhang, Ph.D.) Macromolecular Crystallography Laboratory, CCR

Disruption of Hypoxia-Inducible Transcription Factor-Prolyl Hydroxylase Domain-1 (PHD-1−/−) Attenuates Ex Vivo Myocardial Ischemia/Reperfusion Injury Through Hypoxia-Inducible Factor-1α Transcription Factor and Its Target Genes in Mice

PubMed Central

Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Dunna, Nageswara Rao; Zhan, Lijun; Oriowo, Babatunde; Takeda, Kotaro; Sanchez, Juan A.; Otani, Hajime; Maulik, Gautam; Fong, Guo-Hua

2011-01-01

Abstract Hypoxia-inducible transcription factor (HIF)-prolyl hydroxylases domain (PHD-1–3) are oxygen sensors that regulate the stability of the HIFs in an oxygen-dependent manner. Suppression of PHD enzymes leads to stabilization of HIFs and offers a potential treatment option for many ischemic disorders, such as peripheral artery occlusive disease, myocardial infarction, and stroke. Here, we show that homozygous disruption of PHD-1 (PHD-1−/−) could facilitate HIF-1α-mediated cardioprotection in ischemia/reperfused (I/R) myocardium. Wild-type (WT) and PHD-1−/− mice were randomized into WT time-matched control (TMC), PHD-1−/− TMC (PHD1TMC), WT I/R, and PHD-1−/− I/R (PHD1IR). Isolated hearts from each group were subjected to 30 min of global ischemia followed by 2 h of reperfusion. TMC hearts were perfused for 2 h 30 min without ischemia. Decreased infarct size (35% ± 0.6% vs. 49% ± 0.4%) and apoptotic cardiomyocytes (106 ± 13 vs. 233 ± 21 counts/100 high-power field) were observed in PHD1IR compared to wild-type ischemia/reperfusion (WTIR). Protein expression of HIF-1α was significantly increased in PHD1IR compared to WTIR. mRNA expression of β-catenin (1.9-fold), endothelial nitric oxide synthase (1.9-fold), p65 (1.9-fold), and Bcl-2 (2.7-fold) were upregulated in the PHD1IR compared with WTIR, which was studied by real-time quantitative polymerase chain reaction. Further, gel-shift analysis showed increased DNA binding activity of HIF-1α and nuclear factor-kappaB in PHD1IR compared to WTIR. In addition, nuclear translocation of β-catenin was increased in PHD1IR compared with WTIR. These findings indicated that silencing of PHD-1 attenuates myocardial I/R injury probably by enhancing HIF-1α/β-catenin/endothelial nitric oxide synthase/nuclear factor-kappaB and Bcl-2 signaling pathway. Antioxid. Redox Signal. 15, 1789–1797. PMID:21083501

2017 JOSPT Award Recipients.

PubMed

Simoneau, Guy G

2018-05-01

During the American Physical Therapy Association's Combined Sections Meeting in New Orleans, LA in February 2018, JOSPT recognized the authors of the most outstanding research and clinical practice manuscripts published in JOSPT during 2017. The 2017 George J. Davies-James A. Gould Excellence in Clinical Inquiry Award was presented to Noa Ben-Ami, PT, PhD; Gabriel Chodick, MHA, PhD; Yigal Mirovsky, MD; Tamar Pincus, MPhil, MSc, PhD; and Yair Shapiro, MD, PhD, for their February 2017 article "Increasing Recreational Physical Activity in Patients With Chronic Low Back Pain: A Pragmatic Controlled Clinical Trial." The 2017 JOSPT Excellence in Research Award was presented to Sanneke Don, PT, MPT; Margot de Kooning, PT, PhD; Lennard Voogt, PT, MT, PhD; Kelly Ickmans, PT, PhD; Liesbeth Daenen, PT, PhD; and Jo Nijs, PT, MT, PhD, for their March 2017 article "The Effect of Visual Feedback of the Neck During Movement in People With Chronic Whiplash-Associated Disorders: An Experimental Study." J Orthop Sports Phys Ther 2018;48(5):348. doi:10.2519/jospt.2018.0104.

A fast ellipse extended target PHD filter using box-particle implementation

NASA Astrophysics Data System (ADS)

Zhang, Yongquan; Ji, Hongbing; Hu, Qi

2018-01-01

This paper presents a box-particle implementation of the ellipse extended target probability hypothesis density (ET-PHD) filter, called the ellipse extended target box particle PHD (EET-BP-PHD) filter, where the extended targets are described as a Poisson model developed by Gilholm et al. and the term "box" is here equivalent to the term "interval" used in interval analysis. The proposed EET-BP-PHD filter is capable of dynamically tracking multiple ellipse extended targets and estimating the target states and the number of targets, in the presence of clutter measurements, false alarms and missed detections. To derive the PHD recursion of the EET-BP-PHD filter, a suitable measurement likelihood is defined for a given partitioning cell, and the main implementation steps are presented along with the necessary box approximations and manipulations. The limitations and capabilities of the proposed EET-BP-PHD filter are illustrated by simulation examples. The simulation results show that a box-particle implementation of the ET-PHD filter can avoid the high number of particles and reduce computational burden, compared to a particle implementation of that for extended target tracking.

78 FR 56227 - Issuance of an Experimental Use Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... experimental use permit (EUP) to the pesticide applicant, Robert I. Rose, Ph.D., on behalf of James Mains, Ph.D.... Issuance. Robert I. Rose, Ph.D., on behalf of James Mains, Ph.D., Mosquito Mate, Inc., 1122 Oak Hill Drive...

The Added Value of a PhD in Medicine--PhD Students' Perceptions of Acquired Competences

ERIC Educational Resources Information Center

Anttila, Henrika; Lindblom-Ylänne, Sari; Lonka, Kristi; Pyhältö, Kirsi

2015-01-01

PhD in the field of medicine is more common than in any other domain. Many medical doctors are driven towards PhD, but also students with other backgrounds (usually MSc) are conducting a PhD in medical schools. Higher education has invested a lot in developing generic and research competences. Still little is known about how PhD students…

Cell scientist to watch - Sandra Rieger.

PubMed

2018-06-19

Sandra Rieger studied at the University of Applied Sciences at Fulda, Germany, and wrote her diploma thesis in collaboration with Zyomyx, Inc. (San Francisco, USA). She then joined the laboratory of Reinhard Koester at the Helmholtz Center in Munich to complete her PhD in developmental neurobiology in 2008. For her postdoctoral studies, Sandra moved to the University of California, Los Angeles to work with Alvaro Sagasti on axon regeneration in zebrafish. Since 2011, she has been Assistant Professor for regenerative biology and medicine at the MDI Biological Laboratory in Maine, USA. In the summer of 2018, Sandra will establish a laboratory at the University of Miami, Florida, to become a tenure-track Associate Professor at the Department of Biology. The Rieger laboratory studies cellular communication mechanisms between sensory neurons and injured epidermal cells, leading to wound healing, nerve regeneration and degeneration after injury or exposure to chemotherapeutic agents. © 2018. Published by The Company of Biologists Ltd.

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

PubMed Central

Takeda, Yukiji; Costa, Sandra; Delamarre, Estelle; Roncal, Carmen; de Oliveira, Rodrigo Leite; Squadrito, Mario Leonardo; Finisguerra, Veronica; Deschoemaeker, Sofie; Bruyére, Françoise; Wenes, Mathias; Hamm, Alexander; Serneels, Jens; Magat, Julie; Bhattacharyya, Tapan; Anisimov, Andrey; Jordan, Benedicte F.; Alitalo, Kari; Maxwell, Patrick; Gallez, Bernard; Zhuang, Zhen W.; Saito, Yoshihiko; Simons, Michael; De Palma, Michele; Mazzone, Massimiliano

2015-01-01

PHD2 serves as an oxygen sensor that rescues blood supply by regulating vessel formation and shape in case of oxygen shortage1–5. However, it is unknown whether PHD2 can influence arteriogenesis. Here we studied the role of PHD2 in collateral artery growth by using hindlimb ischaemia as a model, a process that compensates for the lack of blood flow in case of major arterial occlusion6–8. We show that Phd2 (also known as Egln1) haplodeficient (Phd2+/−) mice displayed preformed collateral arteries that preserved limb perfusion and prevented tissue necrosis in ischaemia. Improved arteriogenesis in Phd2+/− mice was due to an expansion of tissue-resident, M2-like macrophages9,10 and their increased release of arteriogenic factors, leading to enhanced smooth muscle cell (SMC) recruitment and growth. Both chronic and acute deletion of one Phd2 allele in macrophages was sufficient to skew their polarization towards a proarteriogenic phenotype. Mechanistically, collateral vessel preconditioning relied on the activation of canonical NF-κB pathway in Phd2+/− macrophages. These results unravel how PHD2 regulates arteriogenesis and artery homeostasis by controlling a specific differentiation state in macrophages and suggest new treatment options for ischaemic disorders. PMID:21983962

The experience of disagreement between students and supervisors in PhD education: a qualitative study

PubMed Central

2013-01-01

Background PhD supervision is mostly individual and disagreement between supervisors and PhD students is a seldom-discussed topic at universities. The present study aimed to describe the experience of disagreement between PhD students and supervisors. Methods Nine supervisors and seven PhD students from Sweden and England were interviewed using a video recorder. The recorded material was analysed using inductive content analysis. Results Disagreements in PhD education can be described with the overarching theme: the nature of the disagreements changes over time. Five categories emerged to describe the variations of the experiences: involvement in important decisions, supervisors not being up-to-date, dubious advice from supervisors, mediating between supervisors, and interpersonal relationships. Conclusions There is a gradual shift in competence where PhD students may excel supervisors in subject knowledge. Early disagreements may indicate immaturity of the student while disagreements later may indicate that the student is maturing making their own decisions. Consequently, disagreements may need to be addressed differently depending on when they occur. Addressing them inappropriately might slow the progressions and result in higher attrition rate among PhD students. The five categories may be elements in future PhD supervisor training programs and should be further evaluated for their importance and impact on PhD education. PMID:24074051

SPATIAL ACCURACY: A CRITICAL FACTOR IN GIS-RELATED ACTIVITIES

EPA Science Inventory

Onsite analyses are critical to making timely decisions. The results of these decisions may not be realized for many years. In order to increase the value of onsite analyses and to create and utilize meaningful environmental models, the Environmental Protection Agency (EPA) dev...

Coast Guard : update on Marine Information for Safety and Law Enforcement System

DOT National Transportation Integrated Search

2001-10-01

The Coast Guard is developing a web-based information system to replace an aging computer system that it uses to track safety and law-enforcement actions involving commercial and recreational vessels. In 1995 the Coast Guard awarded a contract to dev...

Development of the Comprehensive General Parenting Questionnaire for caregivers of 5-13 year olds

USDA-ARS?s Scientific Manuscript database

Despite the large number of parenting questionnaires, considerable disagreement exists about how to best assess parenting. Most of the instruments only assess limited aspects of parenting. To overcome this shortcoming, the "Comprehensive General Parenting Questionnaire" (CGPQ) was systematically dev...

Petrotac bridge deck waterproofing membrane on Five Mile Creek Bridge : first interim report.

DOT National Transportation Integrated Search

1986-09-01

During the 1970's, the Oregon State Highway Division was involved in a Federally funded experimental program to evaluate various waterproofing membrane systems for bridge decks. Through this program, a list of approved products and/or systems was dev...

Calibration of region-specific gates pile driving formula for LRFD : final report 561.

DOT National Transportation Integrated Search

2016-05-01

This research project proposes new DOTD pile driving formulas for pile capacity verification using pile driving blow : counts obtained at either end-of-initial driving (EOID) or at the beginning-of-restrike (BOR). The pile driving : formulas were dev...

Durability of certain configurations for providing skid resistance on concrete pavements.

DOT National Transportation Integrated Search

1974-01-01

The main objective of this study was to establish the factors that influence the durability of the surface configurations that are used or can be used to provide high and long lasting skid resistance for portland cement concrete pavements. In the dev...

Coaching for Better (Software) Buying Power in an Agile World

DTIC Science & Technology

2013-06-01

believes that DevOps , the process of warfighters and developers work- ing together throughout the project, is superior to volumes of detailed...ride on the Consolidated Afloat Networks and Enterprise Services (CANES) infrastructure. This transformation is not easy. It requires a change in

imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel

PubMed Central

Grapov, Dmitry; Newman, John W.

2012-01-01

Summary: Interactive modules for Data Exploration and Visualization (imDEV) is a Microsoft Excel spreadsheet embedded application providing an integrated environment for the analysis of omics data through a user-friendly interface. Individual modules enables interactive and dynamic analyses of large data by interfacing R's multivariate statistics and highly customizable visualizations with the spreadsheet environment, aiding robust inferences and generating information-rich data visualizations. This tool provides access to multiple comparisons with false discovery correction, hierarchical clustering, principal and independent component analyses, partial least squares regression and discriminant analysis, through an intuitive interface for creating high-quality two- and a three-dimensional visualizations including scatter plot matrices, distribution plots, dendrograms, heat maps, biplots, trellis biplots and correlation networks. Availability and implementation: Freely available for download at http://sourceforge.net/projects/imdev/. Implemented in R and VBA and supported by Microsoft Excel (2003, 2007 and 2010). Contact: John.Newman@ars.usda.gov Supplementary Information: Installation instructions, tutorials and users manual are available at http://sourceforge.net/projects/imdev/. PMID:22815358

Zebrafish embryo developmental toxicology assay.

PubMed

Panzica-Kelly, Julieta M; Zhang, Cindy X; Augustine-Rauch, Karen

2012-01-01

A promising in vitro zebrafish developmental toxicology assay was generated to test compounds for their teratogenic potential. The assay's predictivity is approximately 87% in AB strain fish (Brannen KC et al., Birth Defects Res B Dev Reprod Toxicol 89:66-77, 2010). The procedure entails exposing dechorionated gastrulation-stage embryos to a range of compound concentrations for 5 days throughout embryonic and larva development. The larvae are evaluated for viability in order to identify an LC25 (the compound concentration in which 25% lethality is observed) and morphological anomalies using a numerical score system to identify the NOAEL (no observed adverse effect level). These values are used to calculate the teratogenic index (LC25/NOAEL ratio) of each compound. If the teratogenic index is equal to or greater than 10 then the compound is classified as a teratogen, and if the ratio is less than 10 then the compound is classified as a nonteratogen (Brannen KC et al., Birth Defects Res B Dev Reprod Toxicol 89:66-77, 2010).

2017 ISCB Accomplishment by a Senior Scientist Award: Pavel Pevzner

PubMed Central

Fogg, Christiana N.; Kovats, Diane E.; Berger, Bonnie

2017-01-01

The International Society for Computational Biology ( ISCB) recognizes an established scientist each year with the Accomplishment by a Senior Scientist Award for significant contributions he or she has made to the field. This award honors scientists who have contributed to the advancement of computational biology and bioinformatics through their research, service, and education work. Pavel Pevzner, PhD, Ronald R. Taylor Professor of Computer Science and Director of the NIH Center for Computational Mass Spectrometry at University of California, San Diego, has been selected as the winner of the 2017 Accomplishment by a Senior Scientist Award. The ISCB awards committee, chaired by Dr. Bonnie Berger of the Massachusetts Institute of Technology, selected Pevzner as the 2017 winner. Pevzner will receive his award and deliver a keynote address at the 2017 Intelligent Systems for Molecular Biology-European Conference on Computational Biology joint meeting ( ISMB/ECCB 2017) held in Prague, Czech Republic from July 21-July 25, 2017. ISMB/ECCB is a biennial joint meeting that brings together leading scientists in computational biology and bioinformatics from around the globe. PMID:28713548

ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 3: In Vitro to In Vivo: Modeling Life in 3D.

PubMed

Di Mauro, Gianmarco; Dondi, Ambra; Giangreco, Giovanni; Hogrebe, Alexander; Louer, Elja; Magistrati, Elisa; Mullari, Meeli; Turon, Gemma; Verdurmen, Wouter; Cortada, Helena Xicoy; Zivanovic, Sanja

2018-05-22

The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European research institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research-NNF CPR, Denmark; European School of Molecular Medicine-SEMM, Italy) and an innovative science communication agency (Scienseed). With the aim to promote biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event. This gathering includes a top-level scientific symposium bringing together leading scientists, PhD students, and post-doctoral fellows; career development activities supporting the progression of young researchers and fostering discussion about opportunities beyond the bench; outreach activities stimulating the interaction between science and society. The first European PhD and Postdoc Symposium, entitled "Breaking Down Complexity: Innovative models and techniques in biomedicine", was hosted by the vibrant city of Barcelona. The scientific program of the conference was focused on the most recent advances and applications of modern techniques and models in biomedical research and covered a wide range of topics, from synthetic biology to translational medicine. Overall, the event was a great success, with more than 200 attendees from all over Europe actively participating in the symposium by presenting their research and exchanging ideas with their peers and world-renowned scientists.

ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From Discovery to Cure: The Future of Therapeutics.

PubMed

Di Mauro, Gianmarco; Dondi, Ambra; Giangreco, Giovanni; Hogrebe, Alexander; Louer, Elja; Magistrati, Elisa; Mullari, Meeli; Turon, Gemma; Verdurmen, Wouter; Xicoy Cortada, Helena; Zivanovic, Sanja

2018-05-28

The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European Research Institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research-NNF CPR, Denmark; European School of Molecular Medicine-SEMM, Italy) and an innovative science communication agency (Scienseed). With the aim of promoting biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event. This gathering includes a top-level scientific symposium bringing together leading scientists, PhD students, and post-doctoral fellows; career development activities supporting the progression of young researchers and fostering discussion about opportunities beyond the bench; and outreach activities stimulating the interaction between science and society. The first European PhD and Postdoc Symposium, entitled "Breaking Down Complexity: Innovative Models and Techniques in Biomedicine", was hosted by the vibrant city of Barcelona. The scientific program of the conference was focused on the most recent advances and applications of modern techniques and models in biomedical research and covered a wide range of topics, from synthetic biology to translational medicine. Overall, the event was a great success, with more than 200 attendees from all over Europe actively participating in the symposium by presenting their research and exchanging ideas with their peers and world-renowned scientists.

Biomedical PhD education--an international perspective.

PubMed

Mulvany, Michael J

2013-05-01

The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receiving tenured university positions. However, over the past 20-30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the 'knowledge society', and thus increase the competitiveness of their countries in the future economies of the world. Thus, only a small fraction of PhD graduates now end up in academic research. Yet, the PhD remains a research degree, and indeed, institutions have become heavily dependent on PhD students for their research output. The situation has thus created a paradox. On the one hand, it has become essential for institutions to have many PhD students and for the research performed to be of the highest level. On the other hand, the careers of PhD students are not necessarily going to be directly related to the research performed during their PhD studies. The purpose of this article is to explore how this seeming paradox is being addressed in biomedicine and to show that far from being inconsistent that the two aspects are in fact complementary. The article is based on the author's experience as Head of Aarhus Graduate School of Health Sciences 2002-2011 and his work with graduate schools across Europe and internationally through the organization ORPHEUS. © 2013 Nordic Pharmacological Society. Published by Blackwell Publishing Ltd.

Suitability Screening Test for Marine Corps Air Traffic Controllers Phase 2

DTIC Science & Technology

2013-06-10

Karen M. Walker, Ph.D. William L. Farmer, Ph.D. Rebecca C. Roberts, MS Navy Personnel Research, Studies, and Technology NPRST-TR-13-2...June 2013 Suitability Screening Test for Marine Corps Air Traffic Controllers Phase II Karen M. Walker, Ph.D. William L. Farmer, Ph.D. Rebecca...C. Roberts, MS Navy Personnel Research, Studies, and Technology Reviewed by Tanja Blackstone , Ph.D. Approved and released by D. M. Cashbaugh

Suitability Screening Test for Marine Corps Air Traffic Controllers. Phase 2

DTIC Science & Technology

2013-06-01

Karen M. Walker, Ph.D. William L. Farmer, Ph.D. Rebecca C. Roberts, MS Navy Personnel Research, Studies, and Technology NPRST-TR-13-2...June 2013 Suitability Screening Test for Marine Corps Air Traffic Controllers Phase II Karen M. Walker, Ph.D. William L. Farmer, Ph.D. Rebecca...C. Roberts, MS Navy Personnel Research, Studies, and Technology Reviewed by Tanja Blackstone , Ph.D. Approved and released by D. M. Cashbaugh

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

PubMed Central

Henze, Anne-Theres; Garvalov, Boyan K.; Seidel, Sascha; Cuesta, Angel M.; Ritter, Mathias; Filatova, Alina; Foss, Franziska; Dopeso, Higinio; Essmann, Clara L.; Maxwell, Patrick H.; Reifenberger, Guido; Carmeliet, Peter; Acker-Palmer, Amparo; Acker, Till

2014-01-01

Solid tumours are exposed to microenvironmental factors such as hypoxia that normally inhibit cell growth. However, tumour cells are capable of counteracting these signals through mechanisms that are largely unknown. Here we show that the prolyl hydroxylase PHD3 restrains tumour growth in response to microenvironmental cues through the control of EGFR. PHD3 silencing in human gliomas or genetic deletion in a murine high-grade astrocytoma model markedly promotes tumour growth and the ability of tumours to continue growing under unfavourable conditions. The growth-suppressive function of PHD3 is independent of the established PHD3 targets HIF and NF-κB and its hydroxylase activity. Instead, loss of PHD3 results in hyperphosphorylation of epidermal growth factor receptor (EGFR). Importantly, epigenetic/genetic silencing of PHD3 preferentially occurs in gliomas without EGFR amplification. Our findings reveal that PHD3 inactivation provides an alternative route of EGFR activation through which tumour cells sustain proliferative signalling even under conditions of limited oxygen availability. PMID:25420773

APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

PubMed

2016-11-01

The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. The 2016 recipient of the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology was selected by the 2015 Board of Professional Affairs (BPA) and the 2015 APAGS Scholarship and Awards Selection Committee. Members of the 2015 BPA were Patricia Arredondo, EdD; Helen L. Coons, PhD, ABPP; Vickie Mays, PhD, MSPH; Linda A. Reddy, PhD; Lois O. Condi, PhD; Antonette M. Zeiss, PhD; Timothy A. Cavell, PhD; Robert T. Kinscherff, PhD, JD; and Jared L. Skillings, PhD, ABPP. Members of the 2015 APAGS Scholarship and Awards Selection Committee were Emily Voelkel, PhD; Blaire Schembari; and Yolanda Perkins-Volk. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.

PubMed

Astuti, Dewi; Ricketts, Christopher J; Chowdhury, Rasheduzzaman; McDonough, Michael A; Gentle, Dean; Kirby, Gail; Schlisio, Susanne; Kenchappa, Rajappa S; Carter, Bruce D; Kaelin, William G; Ratcliffe, Peter J; Schofield, Christopher J; Latif, Farida; Maher, Eamonn R

2011-02-01

Germline mutations in the von Hippel-Lindau disease (VHL) and succinate dehydrogenase subunit B (SDHB) genes can cause inherited phaeochromocytoma and/or renal cell carcinoma (RCC). Dysregulation of the hypoxia-inducible factor (HIF) transcription factors has been linked to VHL and SDHB-related RCC; both HIF dysregulation and disordered function of a prolyl hydroxylase domain isoform 3 (PHD3/EGLN3)-related pathway of neuronal apoptosis have been linked to the development of phaeochromocytoma. The 2-oxoglutarate-dependent prolyl hydroxylase enzymes PHD1 (EGLN2), PHD2 (EGLN1) and PHD3 (EGLN3) have a key role in regulating the stability of HIF-α subunits (and hence expression of the HIF-α transcription factors). A germline PHD2 mutation has been reported in association with congenital erythrocytosis and recurrent extra-adrenal phaeochromocytoma. We undertook mutation analysis of PHD1, PHD2 and PHD3 in two cohorts of patients with features of inherited phaeochromocytoma (n=82) and inherited RCC (n=64) and no evidence of germline mutations in known susceptibility genes. No confirmed pathogenic mutations were detected suggesting that mutations in these genes are not a frequent cause of inherited phaeochromocytoma or RCC.

APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

PubMed

2017-12-01

The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. The 2017 recipient of the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology was selected by the 2016 Board of Professional Affairs (BPA) and the 2016 APAGS Scholarship and Awards Selection Committee. Members of the 2016 BPA were Antonette M. Zeiss, PhD (Chair); Linda A. Reddy, PhD; Lois O. Condie, PhD; Timothy A. Cavell, PhD; Robert T. Kinscherff, PhD, JD; Jared L. Skillings, PhD, ABPP; Cynthia A. Gómez, PhD; Lisa K. Kearney, PhD, ABPP; and Dinelia Rosa, PhD. Members of the 2016 APAGS Scholarship and Awards Selection Committee were Jerrold Yeo, MA; Jacklynn Fitzgerald, MA; and Roseann Fish Getchell, MA, Med. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Characterization of NF1 Protein Ubiquitination

DTIC Science & Technology

2008-06-01

Ubiquitination PRINCIPAL INVESTIGATOR: Koko Murakami, Ph.D. Victor A Fried, Ph.D. CONTRACTING ORGANIZATION: New York Medical College...NUMBER W81XWH-07-1-0432 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Koko Murakami, Ph.D.; Victor A Fried, Ph.D. 5d. PROJECT NUMBER 5e. TASK

Strategic Studies Quarterly. Volume 8, Number 1, Spring 2014

DTIC Science & Technology

2014-01-01

Charles E. Costanzo, PhD Christopher M. Hemmer, PhD Kimberly A. Hudson, PhD Nori Katagiri, PhD Zachary J . Zwald, PhD Strategic Studies Quarterly (SSQ...first successful carrier-based takeoff and landing with the Jian-15 ( J -15) in November 2012, certified its first group of aircraft carrier pilots and...September 2013.3 The Liaoning will continue to conduct short deployments and shipboard aviation training until 2015 to 2016, when China’s first J -15

BIOREMEDIATION OF HAZARDOUS WASTES - RESEARCH, DEVELOPMENT, AND FIELD EVALUATIONS - 1993

EPA Science Inventory

The proceedings of the 1993 Symposium on Bioremediation of Hazardous Wastes, hosted by the Office of Research and Development (ORD) of the EPA in Dallas, Texas The symposium was the sixth annual meeting for the presentation of research conducts (by EPA's Biosystems Technology Dev...

Lessons from Cotton: Research Projects Following Development of a Community-based Genotyping Array

USDA-ARS?s Scientific Manuscript database

High-throughput, cost-effective genotyping arrays provide a standardized resource for plant breeding communities that can be used for a wide range of applications at a suitable pace for integrating pertinent information into breeding programs. Traditionally, crop research communities will target dev...

Implementation of a Flexible Tool for Automated Literature-Mining and Knowledgebase Development (DevToxMine)

EPA Science Inventory

Deriving novel relationships from the scientific literature is an important adjunct to datamining activities for complex datasets in genomics and high-throughput screening activities. Automated text-mining algorithms can be used to extract relevant content from the literature and...

77 FR 34392 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... and efficacy against renal and prostate cancer cell lines in vivo. The compound can be efficiently... sperm binding persist after replacement of mouse sperm receptors with human homologs. Dev Cell. 2003 Jul....; 301-435- 4074; [email protected] . Englerin A: A Novel Renal Cancer Therapeutic Isolated...

75 FR 3236 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... FEDERAL RESERVE SYSTEM Sunshine Act Meeting AGENCY HOLDING THE MEETING: Board of Governors of the Federal Reserve System. TIME AND DATE: 12 p.m., Monday, January 25, 2010. PLACE: Marriner S. Eccles... Governors of the Federal Reserve System, January 15, 2010. Robert deV. Frierson, Deputy Secretary of the...

DOTD support for UTC project : traffic counting using existing video detection cameras, [research project capsule].

DOT National Transportation Integrated Search

2013-10-01

This study will evaluate the video detection technologies currently adopted by the city : of Baton Rouge, LA, and DOTD with the purpose of establishing design guidelines based : on the detection needs, functionality, and cost. The study will also dev...

The Multilayer Firewall

DTIC Science & Technology

1998-01-01

84. [13] Germano Caronni, Hannes Lubich, Ashar Aziz, Tom Markson, Rich Skrenta, "SKIP - securing the internet," Proceedings of the fifth workshop on...perspective," Open Group Technical Paper DEV-DCE-TP6-1, June 10, 1991. [18] Alan O. Freier, Philip Karlton, Paul C. Kocher, "The SSL Protocol, Version

Hox genes, digit identities and the theropod/bird transition.

PubMed

Galis, Frietson; Kundrát, Martin; Metz, Johan A J

2005-05-15

Vargas and Fallon (2005. J Exp Zool (Mol Dev Evol) 304B:86-90) propose that Hox gene expression patterns indicate that the most anterior digit in bird wings is homologous to digit 1 rather than to digit 2 in other amniotes. This interpretation is based on the presence of Hoxd13 expression in combination with the absence of Hoxd12 expression in the second digit condensation from which this digit develops (the first condensation is transiently present). This is a pattern that is similar to that in the developing digit 1 of the chicken foot and the mouse hand and foot. They have tested this new hypothesis by analysing Hoxd12 and Hoxd13 expression patterns in two polydactylous chicken mutants, Silkie and talpid2. They conclude that the data support the notion that the most anterior remaining digit of the bird wing is homologous to digit 1 in other amniotes either in a standard phylogenetic sense, or alternatively in a (limited) developmental sense in agreement with the Frameshift Hypothesis of Wagner and Gautier (1999, i.e., that the developmental pathway is homologous to the one that leads to a digit 1 identity in other amniotes, although it occurs in the second instead of the first digit condensation). We argue that the Hoxd12 and Hoxd13 expression patterns found for these and other limb mutants do not allow distinguishing between the hypothesis of Vargas and Fallon (2005. J Exp Zool (Mol Dev Evol) 304B:86-90) and the alternative one, i.e., the most anterior digit in bird wings is homologous to digit 2 in other amniotes, in a phylogenetic or developmental sense. Therefore, at the moment the data on limb mutants does not present a challenge to the hypothesis, based on other developmental data (Holmgren, 1955. Acta Zool 36:243-328; Hinchliffe, 1984. In: Hecht M, Ostrom JH, Viohl G, Wellnhofer P, editors. The beginnings of birds. Eichstätt: Freunde des Jura-Museum. p 141-147; Burke and Feduccia, 1997. Science 278:666-668; Kundrát et al., 2002. J Exp Zool (Mol Dev Evol) 294B:151-159; Larsson and Wagner, 2002. J Exp Zool (Mol Dev Evol) 294B:146-151; Feduccia and Nowicki, 2002. Naturwissenschaften 89:391-393), that the digits of bird wings are homologous to digits 2,3,4 in amniotes. We recommend further testing of the hypothesis by comparing Hoxd expression patterns in different taxa. Copyright 2005 Wiley-Liss, Inc

Field implementation of fiber-reinforced polymer (FRP) deck panels.

DOT National Transportation Integrated Search

2017-06-01

Jeffery S. Volz, S.E., P.E., Ph.D., Kamal H. Khayat, PhD, P.Eng. http://orcid.org/0000-0003-1431-0715, Soo Duck Hwang, Ph.D. http://orcid.org/0000-0003-2178-1531, Hesham Tuwair, Ph.D., Jonathan T. Drury, Amy S. Crone : Although still in their infancy...

ESSReS-PEP-POLMAR, an international and interdisciplinary postgraduate education concept on Earth and Environmental Sciences

NASA Astrophysics Data System (ADS)

Meggers, Helge; Hanfland, Claudia; Sprengel, Claudia; Grosfeld, Klaus; Lohmann, Gerrit; Bijma, Jelle; Ladstätter-Weißenmayer, Annette; Burrows, John

2014-05-01

Postgraduate education is gaining increasing importance and has been identified as one instrument to foster quality and promote networking, both in research and in education. Exchange and co-operation between graduate programmes that have related topics produce added value for all. Students have access to a range of research facilities, course offers, and a broad scientific community from which they can start building their individual scientific network. Larger events like PhD conferences, career symposia or cost-intensive trainings are more easily tackled by joining forces of various players. The postgraduate programmes ESSReS-PEP-POLMAR are part of a larger network of marine and climate science programmes in the north-western region of Germany and together host up 180 (23 ESSReS, 130 POLMAR, 30 PEP) PhD/Master students in their respective programmes. Here, we will present a number of joint activities from this collaboration. Today, the PhD education is completely different to that from 15 years ago due to a variety of different scientific offerings including e.g. excursions, soft skill courses and special seminars. In the framework of the ESSReS-PEP-POLMAR concept the Postgraduate Programme Environmental Physics (PEP) at the University of Bremen educates the participants on the complex relationship between atmosphere, hydrosphere (ocean), cryosphere (ice region) and solid earth (land). Here, the learning of experimental methods in environmental physics at the most advanced level, numerical data analysis using supercomputers, and data interpretation via sophisticated methods prepare students for a scientific career. Within cooperation with the Ocean University of China (OUC) students are participating one year in the PEP programme during their master studies since 2006, to get finally a double degree of both universities. Two different ways to further graduation are currently possible at the Alfred Wegener Institute. The Helmholtz Graduate School for Polar and Marine Research (POLMAR) provides a coherent framework for a structured postgraduate programme. POLMAR is a trans disciplinary umbrella organization for currently 130 PhD students and combines high-level science qualification in the various disciplines of polar and marine research with other key qualifications through joint seminars, lectures and practical training. Doctoral education within POLMAR is structured systematically and adapted to the individual needs of the PhD students. The Earth System Science Research School (ESSReS) covers 23 PhD students working at the Alfred Wegener Institute, Helmholtz Center for Polar and Marine Research, the Jacobs University and the University of Bremen. The ESSReS aims at the integration of research at the interface of Biology, Physics, Geophysics, Mathematics and Informatics. It is therefore multi- and interdisciplinary in every aspect. The training, curriculum, and PhD research subjects are closely located at the interfaces between the participating disciplines. This is guaranteed by interdisciplinary supervision of the PhD project, documented by the members of the "PhD committee". The long-term goal is not only to enhance exchange and interaction between these disciplines, but to enforce a new integrated concept, where separation between disciplines becomes obsolete. Consequently, ESSReS-PEP-POLMAR provides a solid base for a new generation of excellent scientists in Earth and Environmental Sciences.

Annual Conference on Human Retrovirus Testing (7th) held in Chicago, IL on March 3-5, 1992

DTIC Science & Technology

1993-04-05

Ph.D.; Charles Sehable, M.S.; Judith Wethers , M.S.; Judith Wilber, Ph.D. This conference was supported, in part, by a firancial graot from the...Westerman Bill Roberts Judith Wethers , M.S. U Col Chester Roberts, Ph.D. Julianne Wiese Jeanette V Roman Helen Wiprud Gene F Robertson, Ph.D. JoAnn L Yee...RHgmor Thorstensson, Ph.D., National Judith Wethers , M.S., Director of Testing Bacteriological Lab Services. Retrovirology Lab.. New York Ralph

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

PubMed

Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Davidson, Shawn M; Schoors, Sandra; Broekaert, Dorien; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouché, Ann; Schoonjans, Luc; Ramer, Matt S; Hung, Gene; Bossaert, Goele; Cleveland, Don W; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Ghesquière, Bart; Fendt, Sarah-Maria; Carmeliet, Peter

2016-02-09

The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network. Instead, PHD1(-/-) neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism. Indeed, PHD1(-/-) neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose away from glycolysis. As a result, PHD1(-/-) neurons increased their redox buffering capacity to scavenge oxygen radicals in ischemia. Intracerebroventricular injection of PHD1-antisense oligonucleotides reduced the cerebral infarct size and neurological deficits following stroke. These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke. Copyright © 2016 Elsevier Inc. All rights reserved.

What Took Them So Long? Explaining PhD Delays among Doctoral Candidates

PubMed Central

van de Schoot, Rens; Yerkes, Mara A.; Mouw, Jolien M.; Sonneveld, Hans

2013-01-01

A delay in PhD completion, while likely undesirable for PhD candidates, can also be detrimental to universities if and when PhD delay leads to attrition/termination. Termination of the PhD trajectory can lead to individual stress, a loss of valuable time and resources invested in the candidate and can also mean a loss of competitive advantage. Using data from two studies of doctoral candidates in the Netherlands, we take a closer look at PhD duration and delay in doctoral completion. Specifically, we address the question: Is it possible to predict which PhD candidates will experience delays in the completion of their doctorate degree? If so, it might be possible to take steps to shorten or even prevent delay, thereby helping to enhance university competitiveness. Moreover, we discuss practical do's and don'ts for universities and graduate schools to minimize delays. PMID:23935895

DELETION OR INHIBITION OF THE OXYGEN SENSOR PHD1 PROTECTS AGAINST ISCHEMIC STROKE VIA REPROGRAMMING OF NEURONAL METABOLISM

PubMed Central

Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Schoors, Sandra; Janaki Raman, Sudha Rani; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouché, Ann; Schoonjans, Luc; Ramer, Matt S.; Hung, Gene; Bossaert, Goele; Cleveland, Don W.; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C. Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Fendt, Sarah-Maria; Ghesquière, Bart; Carmeliet, Peter

2016-01-01

Summary The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network, nor to enhanced neurotrophin expression. Instead, PHD1−/− neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism. Indeed, PHD1−/− neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose from glycolysis. As a result, PHD1−/− neurons increased their redox buffering capacity to scavenge oxygen radicals in ischemia. Intracerebroventricular injection of PHD1-antisense oligonucleotides reduced the cerebral infarct size and neurological deficits following stroke. These data identify PHD1 as a novel regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke. PMID:26774962

CLONING, EXPRESSION, AND MUTATIONAL ANALYSIS OF RAT S-ADENOSYL-1-METHIONINE: ARSENIC (III) METHYLTRANSFERASE

EPA Science Inventory

CLONING, EXPRESSION, AND MUTATIONAL ANALYSIS OF RAT
S-ADENOSYL-L-METHIONINE: ARSENIC(III) METHYLTRANSFERASE

Stephen B. Waters, Ph.D., Miroslav Styblo, Ph.D., Melinda A. Beck, Ph.D., University of North Carolina at Chapel Hill; David J. Thomas, Ph.D., U.S. Environmental...

78 FR 17207 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-20

.... 20130471 G Sun Pharmaceutical Industries Limited; Takeda Pharmaceutical Company Limited; Sun Pharmaceutical.... Martin, Ph.D.; Gilead Sciences, Inc.; John C. Martin, Ph.D. 20130547 G Jindal Poly Films Limited; Exxon... Norbert W. Bischofberger, Ph.D.; Gilead Sciences, Inc.; Norbert W. Bischofberger, Ph.D. 20130611 G...

A Multiattributes Approach for Ranking PhD Programs

ERIC Educational Resources Information Center

Urbancic, Frank R.

2008-01-01

In its plan to combat the PhD shortage crisis, the Association to Advance Collegiate Schools of Business International (AACSB; 2003) has called for the development of PhD program rankings to serve as incentives for academic institutions to invest more in PhD programs, thereby counterbalancing the disproportionate influence of master of business…

The Effects of Low Level Prenatal Carbon Monoxide on Neocortical Development

DTIC Science & Technology

2010-06-02

amount of NO available, which may have formed free radicals damaging the tissue and resulting in cell death. Treatment with a synthetic cGMP also failed...Watkinson B (36- and 48-month neurobehavioral follow-up of children prenatally exposed to marijuana , cigarettes, and alcohol. J Dev Behav Pediatr

Current status of Tomato chlorotic spot virus in Florida and the Caribbean

USDA-ARS?s Scientific Manuscript database

Damaging outbreaks of Tomato chlorotic spot virus (TCSV), an emerging thrips-vectored tospovirus, and several invasive species of thrips are significantly impacting vegetable and other crops in Florida and the Caribbean. Host and geographic ranges of TCSV are continuing to expand in this region. Dev...

Does WISC-IV Underestimate the Intelligence of Autistic Children?

ERIC Educational Resources Information Center

Nader, Anne-Marie; Courchesne, Valérie; Dawson, Michelle; Soulières, Isabelle

2016-01-01

Wechsler Intelligence Scale for Children (WISC) is widely used to estimate autistic intelligence (Joseph in The neuropsychology of autism. Oxford University Press, Oxford, 2011; Goldstein et al. in "Assessment of autism spectrum disorders." Guilford Press, New York, 2008; Mottron in "J Autism Dev Disord" 34(1):19-27, 2004).…

State of Alaska

Science.gov Websites

Alaska Railroad Alaska Maps Alaska Travel Safety Information Alaska Fish and Game Alaska Facts & Month Services How Do I? Education Health Jobs Safety How Do I? Apply for a Permanent Fund Dividend File Information More Dept. of Commerce, Comm... More Dept. of Labor & Workforce Dev. Safety 511 - Traveler

Toxcast Profiling in a Human Stem Cell Assay for Developmental Toxicity (SOT)

EPA Science Inventory

We correlated the ToxCast library in a metabolic biomarker-based in vitro assay (Stemina devTOXqP) utilizing human embryonic stem (hES) cells (H9 line). This assay identifies the concentration of a chemical that disrupts cellular metabolism in a manner indicative of teratogenic...

Demand for Light Duty Trucks : The Wharton EFA Motor Vehicle Demand Model (Mark II).

DOT National Transportation Integrated Search

1981-01-01

A preliminary model of U.S. light-duty vehicle demand is presented which contains an integrated analysis of automobiles and light trucks (under 10,000 lbs. GVW). The model has been estimated using both cross-section and time-series data, and is a dev...

GESTATIONAL PFOA EXPOSURE OF MICE IS ASSOCIATED WITH ALTERED MAMMARY GLAND DEVELOPMENT IN DAMS AND FEMALE OFFSPRING

EPA Science Inventory

Perfluorooctanoic acid (PFOA), a ubiquitous and persistent synthetic compound, has been detected in human serum. Previous studies in mice linked prenatal PFOA exposure to increased neonatal mortality and decreased pup weights, in a dose responsive manner. To determine whether dev...

Evaluation of barrier treatments on native vegetation in a southern California desert habitat

USDA-ARS?s Scientific Manuscript database

Treating perimeters with residual insecticides to provide protection from mosquito vectors has shown promise. These barrier treatments are typically evaluated in temperate or tropical areas using lush, ambient vegetation as a substrate for the pesticide. However, there is an emerging interest to dev...

Introducing a New International Society of Aeolian Research

USDA-ARS?s Scientific Manuscript database

Aeolian research is long-standing and rapidly growing area of study where scientists of many disciplines meet to investigate the effects of wind on the surface of the Earth and other planetary bodies, such as Mars and Titan. Fields of study in aeolian research cover a broad spectrum ranging from dev...

INITIAL CHARACTERIZATION OF MONOCLONAL ANTIBODIES AGAINST THE FUNGAL HEMOLYSIN STACHYLYSIN FROM STACHYBOTRYS CHARTARUM

EPA Science Inventory

Stachybotrys chartarum is known to produce the hemolysin stachylysin and its detection in human serum has been proposed as a biomarker for exposure to the fungus. In this study we report the initial characterization of monoclonal antibodies (mAbs) against stachylysin and the dev...

75 FR 44793 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... FEDERAL RESERVE SYSTEM Sunshine Act Meeting AGENCY HOLDING THE MEETING: Board of Governors of the Federal Reserve System. TIME AND DATE: 3:00 p.m., Tuesday, August 3, 2010. PLACE: Marriner S. Eccles... about the meeting. Board of Governors of the Federal Reserve System, July 27, 2010. Robert deV. Frierson...

75 FR 10795 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... FEDERAL RESERVE SYSTEM Sunshine Act Meeting AGENCY HOLDING THE MEETING: Board of Governors of the Federal Reserve System. TIME AND DATE: 12 p.m., Monday, March 15, 2010. PLACE: Marriner S. Eccles Federal... Federal Reserve System, March 5, 2010. Robert deV. Frierson, Deputy Secretary of the Board. [FR Doc. 2010...

75 FR 5322 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

... FEDERAL RESERVE SYSTEM Sunshine Act Meeting AGENCY HOLDING THE MEETING: Board of Governors of the Federal Reserve System. TIME AND DATE: 11:30 a.m., Monday, February 8, 2010. PLACE: Marriner S. Eccles... Governors of the Federal Reserve System, January 29, 2010. Robert deV. Frierson, Deputy Secretary of the...

EVALUATION OF THE CARBON FOOTPRINT OF INNOVATIVE WATER MAIN REHABILITATION TECHNOLOGIES VS. OPEN CUT METHODS

EPA Science Inventory

A major benefit of trenchless rehabilitation technologies touted by many practitioners when comparing their products with tradition open cut construction methods is lower carbon dioxide (CO₂) emissions. In an attempt to verify these claims, multiple tools have been dev...

Visualizing Mixed Variable-Type Multidimensional Data Using Tree Distances

DTIC Science & Technology

2015-09-01

24 1. The Regression Method .................................................. 25 2. Maximum Deviance Ratio Method... Deviance Change as a Factor of the Amount of Correlation? ................................................... 50 B. A PROPOSED SOLUTION...Splice mapping using d1 ...................... 36 Figure 18. Reduction in 2R analog ( deviance ratio-DevRat) per variable for the Splice data

Net-centric ACT-R-Based Cognitive Architecture with DEVS Unified Process

DTIC Science & Technology

2011-04-01

effort has been spent in analyzing various forms of requirement specifications, viz, state-based, Natural Language based, UML-based, Rule- based, BPMN ...requirement specifications in one of the chosen formats such as BPMN , DoDAF, Natural Language Processing (NLP) based, UML- based, DSL or simply

Automation and Robotics in Construction: Japanese Research and Development

DTIC Science & Technology

1989-10-01

P’rocurei’ment D5epartrnentDivisionEH Nuclear Fac. Engr. p pt. Administration Department Products Dev. Department Housing _jInformation Systems Dept. Sales ... Promotion Division Depart Figure 2. Taisei administrative structure. 13 hgtre . Tisc tehnial erch. Ioramation.Srvc Shimiznfn~~aera Secpotion bil

Self-Perceived Stability and Change in Children's Competence

ERIC Educational Resources Information Center

Vandenplas-Holper, Christiane; Roskam, Isabelle; Fontaine, Anne-Marie

2010-01-01

Using Harter's ("Child Dev" 53(1):87-97, 1982) perceived competence scale, this study integrates several paradigms related to the issues of self-perceived competence, stability or change and attributional theory. It examines how 268 Belgian and Portuguese fifth graders consider their scholastic, social and physical competence at present…

Environmental history impacts gene expression during diapause development in the alfalfa leafcutting bee, Megachile rotundata

USDA-ARS?s Scientific Manuscript database

Our understanding of the mechanisms controlling insect diapause has increased dramatically with the introduction of global gene expression techniques, such as RNAseq. However, little attention has been given to how ecologically relevant field conditions may affect gene expression during diapause dev...

Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia.

PubMed

Yang, Chunzhang; Zhuang, Zhengping; Fliedner, Stephanie M J; Shankavaram, Uma; Sun, Michael G; Bullova, Petra; Zhu, Roland; Elkahloun, Abdel G; Kourlas, Peter J; Merino, Maria; Kebebew, Electron; Pacak, Karel

2015-01-01

We have investigated genetic/pathogenetic factors associated with a new clinical entity in patients presenting with pheochromocytoma/paraganglioma (PHEO/PGL) and polycythemia. Two patients without hypoxia-inducible factor 2α (HIF2A) mutations, who presented with similar clinical manifestations, were analyzed for other gene mutations, including prolyl hydroxylase (PHD) mutations. We have found for the first time a germ-line mutation in PHD1 in one patient and a novel germ-line PHD2 mutation in a second patient. Both mutants exhibited reduced protein stability with substantial quantitative protein loss and thus compromised catalytic activities. Due to the unique association of patients' polycythemia with borderline or mildly elevated erythropoietin (EPO) levels, we also performed an in vitro sensitivity assay of erythroid progenitors to EPO and for EPO receptor (EPOR) expression. The results show inappropriate hypersensitivity of erythroid progenitors to EPO in these patients, indicating increased EPOR expression/activity. In addition, the present study indicates that HIF dysregulation due to PHD mutations plays an important role in the pathogenesis of these tumors and associated polycythemia. The PHD1 mutation appears to be a new member contributing to the genetic landscape of this novel clinical entity. Our results support the existence of a specific PHD1- and PHD2-associated PHEO/PGL-polycythemia disorder. • A novel germ-l i n e PHD1 mutation causing heochromocytoma/paraganglioma and polycythemia. • Increased EPOR activity and inappropriate hypersensitivity of erythroid progenitors to EPO.

Pre-hospital discharge testing of defibrillator without anesthesia: effects on psychological symptoms during clinical follow-up.

PubMed

Petrowski, Katja; Wintermann, Gloria-Beatrice; Petzold, Christian; Strasser, Ruth H; Guenther, Michael

2013-09-01

After the implantation of an implantable cardioverter-defibrillator (ICD), patients often fear therapeutic shock. The extent to which the experience of pre-hospital discharge (PHD) testing without anesthesia after ICD implantation, under observation by a physician, affects shock-related anxiety symptoms on follow-up has not been investigated as yet. In a prospective, randomized controlled trial, 44 patients with a primary prevention indication for an ICD were randomly assigned to experience PHD testing without anesthesia (n = 23) or with anesthesia (n = 21). Patients were longitudinally evaluated before (T(1)), shortly after (T(2)), and 3 months after (T(3)) PHD testing. During the respective PHD testings, the course of patients' serum cortisol release was measured. During PHD testing, patients without anesthesia showed a significantly higher serum cortisol release than patients with anesthesia (F(4,152) = 22.227, p < .001). Patients who experienced PHD testing without anesthesia felt significantly safer with the ICD (U = 165.000, p = .040), would significantly more often recommend other patients to undergo PHD testing without anesthesia (χ(2) = 12.013, p = .002), and showed significantly lower levels of general shock-related anxiety shortly afterward (F(1,42) = 6.327, p = .02) and 3 months after PHD testing (F(1,41) = 8.603, p = .005). The implementation of PHD testing without anesthesia is associated with lower anxiety concerning therapeutic shock. Patients should be advised about the effects of PHD testing without anesthesia on their psychological well-being in the long run.

Meaningful Engagement of Organizational and Agency Partnerships to Enhance Diversity within the Earth System Science Community: A Case Study

NASA Astrophysics Data System (ADS)

Pyrtle, A. J.; Whitney, V. W.; Powell, J. M.; Bailey, K. L.

2006-12-01

The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science Initiative (MS PHD'S) was established by and for underrepresented minorities to facilitate increased and sustained participation in Earth system science community. The MS PHD'S launched its pilot program in 2003 with twenty professional organizations, agencies and institutions as partners. Each year partnership alliances have grown. In the second year or programming, thirty-one partnering agencies/institutions supported involvement of MS PHD'S student participants and for 2005-2006, representatives from forty-five agencies and institutions have provided similar support and exposure to the third cohort of student participants. Nineteen scientists served as meeting mentors during the MS PHD'S pilot program in 2003. By the following year, twenty-two additional scientists partnered with MS PHD'S mentees. During 2005-2006, twenty-one new scientists served as program mentors. Thus far, the MS PHD'S program has successfully engaged sixty-two minority and non-minority scientists as mentors to MS PHD'S student participants. AGU, AMS, ASLO, ESA, TOS, NAS OSB and JOI continue to serve as MS PHD'S Society Partners and hosts for MS PHD'S student activities in conjunction with their meetings. Each of the five professional society partners provided assistance in identifying mentors, provided complimentary memberships and meeting registrations for MS PHD'S student participants. AGU, AMS, ASLO, JOI and TOS have sponsored more than 90 conference registration and travel awards for the purpose of student participants engaging in MS PHD'S Professional Development Program Phase 2 activities at their international meetings. How did MS PHD'S establish meaningful engagement of organizational and agency partnerships to enhance diversity within the Earth system science community? This case study reveals replicable processes and constructs to enhance the quality of meaningful collaboration and engagement. In addition, the study addresses frequently asked questions (FAQ's) on the formation and sustenance of partnerships among principal investigators and evaluators and the impact of this partnership on writing proposals, implementing and evaluating program activities and outcomes.

I-determinants for a successful PhD or postdoctoral outcome.

PubMed

Sørensen, Henrik Toft

2016-01-01

Many resources are invested in research training, but very little literature exists on predictors for a successful PhD and postdoctoral training outcome. A PhD program has two overall objectives: to extend knowledge about a hopefully important health topic and to provide extensive training to improve the PhD student's skills through learning research methods and collaboration. A substantial number of PhD students may run into some kind of problem in the course of their PhD program. In this article, some determinants all starting with an "I" and indicative of a good PhD outcome are reported. The successful PhD student can be described as having an Interest in the PhD program, an Incentive for the program, and an Idea of what he or she wants to investigate, showing Initiative, and having high personal Integrity and good Interpersonal relationships. When these so-called I-determinants are present, the likelihood of success in a PhD program is high. More evidence is available for selection of candidates for postdoctoral appointments since it is known that the postdoctoral candidate has completed a PhD program, published papers in peer-reviewed journals, and received awarded grants. However, other characteristics determine a successful transition of the postdoctoral candidate into a research leader. These determinants are Identity, Independence and Image, Implementation ability in terms of being able to implement decisions and projects, working with Innovative and Important topics, having In-depth knowledge of the research topic, being Interactive and Integrated with the scientific community, and Internationally oriented. In conclusion, regardless of the framework of research, the personal characteristics of a researcher play a very important role in the quality of research. Application of some of the principles mentioned in this article might allow decision to reach a more evidence-based way to recruit PhD students and postdoctorals.

I-determinants for a successful PhD or postdoctoral outcome

PubMed Central

Sørensen, Henrik Toft

2016-01-01

Many resources are invested in research training, but very little literature exists on predictors for a successful PhD and postdoctoral training outcome. A PhD program has two overall objectives: to extend knowledge about a hopefully important health topic and to provide extensive training to improve the PhD student’s skills through learning research methods and collaboration. A substantial number of PhD students may run into some kind of problem in the course of their PhD program. In this article, some determinants all starting with an “I” and indicative of a good PhD outcome are reported. The successful PhD student can be described as having an Interest in the PhD program, an Incentive for the program, and an Idea of what he or she wants to investigate, showing Initiative, and having high personal Integrity and good Interpersonal relationships. When these so-called I-determinants are present, the likelihood of success in a PhD program is high. More evidence is available for selection of candidates for postdoctoral appointments since it is known that the postdoctoral candidate has completed a PhD program, published papers in peer-reviewed journals, and received awarded grants. However, other characteristics determine a successful transition of the postdoctoral candidate into a research leader. These determinants are Identity, Independence and Image, Implementation ability in terms of being able to implement decisions and projects, working with Innovative and Important topics, having In-depth knowledge of the research topic, being Interactive and Integrated with the scientific community, and Internationally oriented. In conclusion, regardless of the framework of research, the personal characteristics of a researcher play a very important role in the quality of research. Application of some of the principles mentioned in this article might allow decision to reach a more evidence-based way to recruit PhD students and postdoctorals. PMID:27574466

Development and evaluation of a peer-tutoring program for graduate students*.

PubMed

Copeland, H Liesel; Kinzy, Terri Goss

2005-03-01

Many interdisciplinary Ph.D. programs admit students of different educational backgrounds who receive a first year of a general curriculum education. However, student preparation for this curriculum varies, and methods are needed to provide academic support. Graduate student peer tutoring was piloted as an initiative funded by a National Institutes of Health (NIH) Initiative for Minority Student Development award to the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS) and is now offered to all students in the interdisciplinary Molecular Biosciences Ph.D. program between Rutgers, The State University of New Jersey, and UMDNJ-RWJMS. Tutoring occurs individually or in small groups and has grown over the past 5 years in the number of students tutored and hours of tutoring. The program was evaluated by surveying and interviewing both tutors and students concerning process variables (e.g. awareness, frequency) and impact variables (e.g. perceived benefits, motivators), as well as by assessing changes in exam scores for the four core courses of the first-year graduate curriculum. Copyright © 2005 International Union of Biochemistry and Molecular Biology, Inc.

STS-85 Day 08 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this eighth day of the STS-85 mission, the flight crew, Cmdr. Curtis L. Brown, Jr., Pilot Kent V. Rominger, Payload Cmdr. N. Jan Davis (Ph.D.), Mission Specialists Robert L. Curbeam, Jr. and Stephen K. Robinson (Ph.D.), and Payload Specialist Bjarni V. Tryggvason entered the final portion of its flight. The new Mir 24 crew of Commander Anatoly Solovyev and Flight Engineer Pavel Vinogradov, who arrived on the station the same day Discovery was launched, bid farewell to Mir 23 Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin who are returning home after 185 days in space. The Soyuz vehicle carrying the Mir 23 crew home undocked from the station. Robinson again used the Southwest Ultraviolet Imaging System (SWUIS), a 7-inch imaging telescope that is pointed out of the orbiter's middeck hatch window, to observe the Hale-Bopp comet. Curbeam continued his work with the Bioreactor Demonstration System designed to perform cell biology experiments under controlled conditions. Tryggvason spent part of his time troubleshooting a computer hard drive system that supports the Microgravity Vibration Isolation Mount experiment.

NASA Graduate Student Researchers Program Ronald E. McNair PhD Program

NASA Technical Reports Server (NTRS)

Howard, Sunnie

1998-01-01

The NASA Ronald E. McNair PHD Program was funded in September 1995. Implementation began during the spring of 1996. The deferment of the actual program initial semester enabled the program to continue support through the fall semester of 1998. This was accomplished by a no-cost extension from August 15, 1998 through December 31, 1998. There were 12 fellows supported by the program in 1996, 15 fellows in 1997, and 15 fellows 1998. Current program capacity is 15 fellows per funding support. Support for the academic outreach component began in spring 1998. The program was named the "Good Enough" Crew Activity (GECA) in honor of Dr. McNair's philosophy of everyone being good enough to achieve anything they want bad enough. The program currently enrolls 65 students from the third through the eight grades. The program is held 12 Saturdays per semester. The time is 9:00 AM to 12:30 PM each Saturday Morning. Program direction and facilitation is jointly administered with the PHD fellows and the Saturday Academy staff. Dr. John Kelly, REM-PHD Principal Investigator serves in a program oversight and leadership capacity. Ms. Sunnie Howard, The NASA REM-PHD Administrative Coordinator serves in an administrative and logistical capacity. Mr. Aaron Hatch, the NASA-AMES Liaison Officer, serve@'in a consultative and curriculum review capacity. The first recognition activity will be held on December 12, 1998, with the students, parents, faculty, PHD fellows, and other local student support services persons. Program outreach efforts are jointly supported by the NASA REM-PHD Program and the National Space Grant College and Fellowship Program. The Ph.D. program reached its first milestone in May 1998. North Carolina A&T State University graduated the first Ph.D. fellows. The first three Ph.D. Alumni were Ronald E. McNair PHD Program Fellows. It is hoped that this is just the beginning of a highly acclaimed doctoral program. The ultimate program success will be recognized when the program begins to graduate 15 fellows per year. The Ph.D. Program is only three and a half years old and the expectations of graduating PH.D's in that timeframe, is a phenomenal accomplishment for any program in the country. Since inception of the NASA REM-PHD program, tuitions and fees have increased. Stipend support was increased to offer the Ph.D. program on a competitive basis. These increases will place allocation restraints on r_ the current level of funding. These issues are being addressed in the proposal and will bear their own merit.

The 2014/15 Warm Anomaly in the Southern California Current - Physical and Biological Responses

NASA Astrophysics Data System (ADS)

Ralf, G.

2016-02-01

The 2014/15 Warm Anomaly (WarmA) off Southern California manifested itself in the summer of 2014 as an anomalously warm surface layer in the Southern Calif. Bight with low concentrations of Chl a. This layer intensified in spatial extent, covering the entire CalCOFI surface area by the winter of 2015 with temperature anomalies 3 StDev larger than long-term averages. Concentrations of nutrients, phytoplankton biomass and rates of primary production were extremely low during the WarmA. The evolution of the WarmA as well as the 2015/16 El Niño with time will be compared to the evolution of the weak and strong El Niño's observed over the last 60 years. These events provide unique insights in the controls of phytoplankton biomass and production in the southern California Current System. Preliminary analyses suggest that the response of the phytoplankton community to the WarmA was consistent with responses to similar forcing during the prior decade. This presentation is based on data collected during the quarterly CalCOFI cruises by the CalCOFI and the CCE-LTER groups.

Nervous system development and regeneration in freshwater planarians.

PubMed

Ross, Kelly G; Currie, Ko W; Pearson, Bret J; Zayas, Ricardo M

2017-05-01

Planarians have a long history in the fields of developmental and regenerative biology. These animals have also sparked interest in neuroscience due to their neuroanatomy, spectrum of simple behaviors, and especially, their almost unparalleled ability to generate new neurons after any type of injury. Research in adult planarians has revealed that neuronal subtypes homologous to those found in vertebrates are generated from stem cells throughout their lives. This feat is recapitulated after head amputation, wherein animals are capable of regenerating whole brains and regaining complete neural function. In this review, we summarize early studies on the anatomy and function of the planarian nervous system and discuss our present knowledge of the molecular mechanisms governing neurogenesis in planarians. Modern studies demonstrate that the transcriptional programs underlying neuronal specification are conserved in these remarkable organisms. Thus, planarians are outstanding models to investigate questions about how stem cells can replace neurons in vivo. WIREs Dev Biol 2017, 6:e266. doi: 10.1002/wdev.266 For further resources related to this article, please visit the WIREs website. © 2017 Wiley Periodicals, Inc.

Online PhD Program Delivery Models and Their Relationship to Student Success

ERIC Educational Resources Information Center

Jorissen, Shari L.

2012-01-01

Attrition rates in Ph.D. programs are at approximately 50% in traditional Ph.D. programs and 10-20% higher in online Ph.D. programs. Understanding the relationship between student factors, measures of student success (retention, graduation, year to degree), and student satisfaction is important to support and improve retention, graduation rates,…

Undertaking Individual Transdisciplinary PhD Research for Sustainable Development: Case Studies from South Africa

ERIC Educational Resources Information Center

van Breda, John; Musango, Josephine; Brent, Alan

2016-01-01

Purpose: This paper aims to improve the understanding of individual transdisciplinary PhD research in a developing country context, focusing on three individual PhD case studies in South Africa. Design/Methodology/Approach: Multiple-case method was used, and three completed transdisciplinary PhD research efforts undertaken at the Stellenbosch…

PhD Funding as a Determinant of PhD and Career Research Performance

ERIC Educational Resources Information Center

Horta, Hugo; Cattaneo, Mattia; Meoli, Michele

2018-01-01

This article focuses on the effects of PhD funding on research performance both during the degree and throughout researchers' careers as measured through publications and citations. This analysis draws from a representative sample of researchers holding a doctorate based in Portugal and finds that those funded by grants during the PhD perform…

International PhD Students in Australian Universities: Financial Support, Course Experience and Career Plans

ERIC Educational Resources Information Center

Harman, G.

2003-01-01

Using data from a social survey of PhD students in two major Australian universities supplemented by student interviews, this article reports on the financial support, course experience and career plans of international PhD students. While most international PhD students hold scholarships which include stipends, a minority of students experience…

A Reconsideration of the Ph.D.

ERIC Educational Resources Information Center

Nichols, Roy F.

1967-01-01

One of the major problems in doctoral education, the shortage of Ph.D. holders, is discussed. A brief history of the German influence on graduate schools in the United States is given to suggest the reasons why the traditional Ph.D. is not designed for present needs. Suggestions are given for a more effective Ph.D. curriculum which will meet the…

High Power, Millimeter-Wavelength, Coherent Radiation Sources.

DTIC Science & Technology

1986-09-25

J . Murphy, Ph.D. (1982). 5. M. Abdelkarim , Ph.D. (1984). 6. T. Buller, Ph.D. (1985). a 7. B. Johnson, Ph.D. (1985). 8. E. Garate, Ph.D. (1985). 9. R...AD-A174 521 HIGH POWER KILL IMETER-WAVELENGTH COHERENTRAITO 1/ SOURCES(U) DARTMOUTH COLL HANOVER N H DEPT OF PHYSICS AND ASTRONOMY J E WALSH 25 SEP...82 - 1/31/86 -.: AIR F , 2 ..... . . T . ... ...... , 7 Approved for public release;"":" " ’n2. j ;’L’-’ ,- -"!d ,-d 12 l . 7. ... - ’ " + d. Chief

Education Program for Ph.D. Course to Cultivate Literacy and Competency

NASA Astrophysics Data System (ADS)

Yokono, Yasuyuki; Mitsuishi, Mamoru

The program aims to cultivate internationally competitive young researchers equipped with Fundamental attainment (mathematics, physics, chemistry and biology, and fundamental social sciences) , Specialized knowledge (mechanical dynamics, mechanics of materials, hydrodynamics, thermodynamics, design engineering, manufacturing engineering and material engineering, and bird‧s-eye view knowledge on technology, society and the environment) , Literacy (Language, information literacy, technological literacy and knowledge of the law) and Competency (Creativity, problem identification and solution, planning and execution, self-management, teamwork, leadership, sense of responsibility and sense of duty) to become future leaders in industry and academia.

Subsurface Microbes Expanding the Tree of Life

ScienceCinema

Banfield, Jillian

2018-02-14

Jillian Banfield, Ph.D., UC Berkeley Professor and Berkeley Lab Earth Sciences Division staff scientist and long-time user of the DOE Joint Genome Institute’s resources shares her perspective on how the DOE JGI helps advance her research addressing knowledge gaps related to the roles of subsurface microbial communities in biogeochemical cycling. The video was filmed near the town of Rifle, Colorado at the primary field site for Phase I of the Subsurface Systems Scientific Focus Area 2.0 sponsored by the DOE Office of Biological and Environmental Research.

Flying over decades

NASA Astrophysics Data System (ADS)

Hoeller, Judith; Issler, Mena; Imamoglu, Atac

Levy flights haven been extensively used in the past three decades to describe non-Brownian motion of particles. In this presentation I give an overview on how Levy flights have been used across several disciplines, ranging from biology to finance to physics. In our publication we describe how a single electron spin 'flies' when captured in quantum dot using the central spin model. At last I motivate the use of Levy flights for the description of anomalous diffusion in modern experiments, concretely to describe the lifetimes of quasi-particles in Josephson junctions. Finished PhD at ETH in Spring 2015.

New insights into the dual role of TGF-beta | Center for Cancer Research

Cancer.gov

The dual role of TGF-beta in cancer continues to challenge investigators in the field. TGF-beta is a well-known factor associated with tumor suppression in normal cells and yet promotes tumor progression in advanced stages of cancer. For years, the mechanisms that underpin this conundrum have not been fully understood. Ying Zhang, Ph.D., senior investigator in the Laboratory of Cellular and Molecular Biology, has been exploring this problem by examining and characterizing several key molecules in the TGF-beta signaling pathway. Read more…

Perspective.

PubMed

Wolpert, Lewis

2015-01-01

I am a developmental biologist, but I started off as a civil engineer. I did some research on soil mechanics but decided to change to biology. A friend changed my life when he told me about the mechanics of cell division, on which I did my PhD at Kings College. I then worked on the morphogenesis of the sea urchin embryo and became interested in how embryos are patterned, and I proposed positional information as a basic mechanism. I was a professor at the Middlesex Hospital Medical School, where we concentrated on how the chick limb developed.

Effects of Ultraviolet Radiation on the Oxygen Uptake Rate of the Rabbit Cornea

DTIC Science & Technology

1989-07-01

typical of a noncoherent source Optometrist, Ph.D. exposure. IV Effects on Corneal Oxygen Uptake-Lattimore 117 AvxAtl,-blity Codes 1- -il and/or , "t i...romator entrance slit by the housing optics . A 10 reciprocity (i.e., the biologic effects or endpoints cm quartz-enclosed water chamber was placed be...remove the infrared radiation. The exit optical taneous output at 350.7 and 356.4 nm (3:1 ratio), beam was focused by a quartz lens with a beam size

Acceptance of a systematic review as a thesis: survey of biomedical doctoral programs in Europe.

PubMed

Puljak, Livia; Sapunar, Damir

2017-12-12

Systematic reviews (SRs) have been proposed as a type of research methodology that should be acceptable for a graduate research thesis. The aim of this study was to analyse whether PhD theses in European biomedical graduate programs can be partly or entirely based on SRs. In 2016, we surveyed individuals in charge of European PhD programs from 105 institutions. The survey asked about acceptance of SRs as the partial or entire basis for a PhD thesis, their attitude towards such a model for PhD theses, and their knowledge about SR methodology. We received responses from 86 individuals running PhD programs in 68 institutions (institutional response rate of 65%). In 47% of the programs, SRs were an acceptable study design for a PhD thesis. However, only 20% of participants expressed a personal opinion that SRs meet the criteria for a PhD thesis. The most common reasons for not accepting SRs as the basis for PhD theses were that SRs are 'not a result of a PhD candidate's independent work, but more of a team effort' and that SRs 'do not produce enough new knowledge for a dissertation'. The majority of participants were not familiar with basic concepts related to SRs; questions about meta-analyses and the type of plots frequently used in SRs were correctly answered by only one third of the participants. Raising awareness about the importance of SRs and their methodology could contribute to higher acceptance of SRs as a type of research that forms the basis of a PhD thesis.

Driver performance and behavior in adverse weather conditions : an investigation using the SHRP2 naturalistic driving study data--phase 1.

DOT National Transportation Integrated Search

2015-12-01

Mohamed M. Ahmed, Ph.D., P.E. (orcid.org/0000-0002-1921-0724) : Ali Ghasemzadeh, M.Sc. (orcid.org/0000-0003-1232-251X) : Hesham Eldeeb, Ph.D. : Sherif Gaweesh, M.Sc. (orcid.org/0000-0001-7977-6378) : Joshua Clapp, Ph.D. : Khaled Ksaibati, Ph.D., P.E....

How Prepared Are MSW Graduates for Doctoral Research? Views of PhD Research Faculty

ERIC Educational Resources Information Center

Drisko, James W.; Evans, Kristin

2018-01-01

This national survey of PhD faculty assessed the research preparation of entering doctoral social work students on a wide range of research knowledge and related skills. The prior literature shows that PhD programs repeat much BSW and MSW research course content. This study shows that the trend continues and has perhaps widened. PhD research…

Academic and research misconduct in the PhD: issues for students and supervisors.

PubMed

Mitchell, Theresa; Carroll, Jude

2008-02-01

There are many pressures upon PhD students not least the requirement to make an original or significant contribution to knowledge. Some students, confronted with complex research processes, might adopt practices that compromise standards that are unacceptable within a research community. These practices challenge the PhD student-supervisor relationship and have implication for the individual, the supervisory team, the institution, the awarding body and the wider research context. Discussion relating to misconduct within the PhD is of international importance if the aim is to encourage and facilitate rigorous research practice. Cases involving academic and research misconduct, especially those occurring at PhD level, are likely to become more frequent as numbers of PhD students increase and will demand appropriate, defensible responses from supervisors. Misconduct during PhD study can be difficult to resolve because of lack of clarity in definitions, supervisor naiveté and failure to acknowledge students' decision making limitations. Using scenarios from the first author's supervisory practice to illustrate issues of concern for students and supervisors during PhD supervision, the authors aim to illuminate the importance of engagement with regulatory bodies; problems of knowledge and understanding transfer; culturally specific issues and meanings of academic theft.

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

PubMed Central

Loges, Sonja; Schmidt, Thomas; Jonckx, Bart; Tian, Ya-Min; Lanahan, Anthony A.; Pollard, Patrick; de Almodovar, Carmen Ruiz; De Smet, Frederik; Vinckier, Stefan; Aragonés, Julián; Debackere, Koen; Luttun, Aernout; Wyns, Sabine; Jordan, Benedicte; Pisacane, Alberto; Gallez, Bernard; Lampugnani, Maria Grazia; Dejana, Elisabetta; Simons, Michael; Ratcliffe, Peter; Maxwell, Patrick; Carmeliet, Peter

2014-01-01

SUMMARY A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2+/− mice. Haplodeficiency of PHD2 did not affect tumor vessel density or lumen size, but normalized the endothelial lining and vessel maturation. This resulted in improved tumor perfusion and oxygenation and inhibited tumor cell invasion, intravasation, and metastasis. Haplodeficiency of PHD2 redirected the specification of endothelial tip cells to a more quiescent cell type, lacking filopodia and arrayed in a phalanx formation. This transition relied on HIF-driven upregulation of (soluble) VEGFR-1 and VE-cadherin. Thus, decreased activity of an oxygen sensor in hypoxic conditions prompts endothelial cells to readjust their shape and phenotype to restore oxygen supply. Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy. PMID:19217150

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue

PubMed Central

Kim, Min; Neinast, Michael D.; Frank, Aaron P.; Sun, Kai; Park, Jiyoung; Zehr, Jordan A.; Vishvanath, Lavanya; Morselli, Eugenia; Amelotte, Mason; Palmer, Biff F.; Gupta, Rana K.; Scherer, Philipp E.; Clegg, Deborah J.

2014-01-01

Hypoxia Inducible Factor 1 (HIF-1) promotes fibrosis and inflammation in adipose tissues, while estrogens and Estrogen Receptor α (ERα) have the opposite effect. Here we identify an Estrogen Response Element (ERE) in the promoter of Phd3, which is a negative regulatory enzyme of HIF-1, and we demonstrate HIF-1α is ubiquitinated following 17-β estradiol (E2)/ERα mediated Phd3 transcription. Manipulating ERα in vivo increases Phd3 transcription and reduces HIF-1 activity, while addition of PHD3 ameliorates adipose tissue fibrosis and inflammation. Our findings outline a novel regulatory relationship between E2/ERα, PHD3 and HIF-1 in adipose tissues, providing a mechanistic explanation for the protective effect of E2/ERα in adipose tissue. PMID:25161887

Award for Distinguished Contributions to the International Advancement of Psychology.

PubMed

2017-12-01

This award is given to individuals who have made sustained and enduring contributions to international cooperation and the advancement of knowledge in psychology. The 2017 recipient of the APA Award for Distinguished Contributions to the International Advancement of Psychology was selected by the 2016 Committee on International Relations in Psychology (CIRP). The members of the 2016 CIRP were Melissa Morgan Consoli, PhD, and Arpana G. Inman, PhD (Co-chairs); Rehman Abdulrehman, PhD; Gonzalo Bacigalupe, EdD; Frederic Bemak, EdD; Brigitte Khoury, PhD; Susan Nolan, PhD; Nancy Sidun, PsyD; and Danny Wedding, PhD. Dr. Morgan Consoli, Dr. Inman, Dr. Nolan, and Doctor Sidun were members of the subcommittee for the 2017 award. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Using a nursing theory or a model in nursing PhD dissertations: a qualitative study from Turkey.

PubMed

Mete, Samiye; Gokçe İsbir, Gozde

2015-04-01

The aim of this study was to reveal experiences of nursing students and their advisors using theories and models in their PhD dissertations. The study adopted a descriptive qualitative approach. This study was performed with 10 PhD candidates and their five advisors from nursing faculty. The results of the study were categorized into four. These are reasons for using a theory/model in a PhD dissertation, reasons for preferring a given model, causes of difficulties in using models in PhD dissertations, and facilitating factors of using theories and models in PhD of dissertations. It was also reported to contribute to the methodology of research and professional development of the students and advisors. © 2014 NANDA International, Inc.

Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

NASA Astrophysics Data System (ADS)

Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

2012-12-01

In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS professionals who are committed to achieving successful careers and supporting one another. This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing MS PHD'S B-PhD activities, and "next steps" for the MS PHD'S B-PhD Professional Development Program.

Developing Discourses of Knowledge and Understanding: Longitudinal Studies of Ph.D. Supervision

ERIC Educational Resources Information Center

Kandiko, Camille B.; Kinchin, Ian M.

2013-01-01

Competing notions of what a Ph.D. has been, is and should be are undercurrents in doctoral education. A longitudinal study of Ph.D. supervision based on interviews and concept mapping was used to surface understandings of the purpose of a Ph.D. This research tracks change over time for both the student and the supervisor. The data were analysed…