Development of alternative wood-post MGS approach guardrail transition.

DOT National Transportation Integrated Search

2011-11-28

The objective of this study was to develop a wood-post MGS approach transition system that is equivalent to the : simplified steel-post, MGS stiffness transition recently developed at the Midwest Roadside Safety Facility. An extensive : literature re...

Alternative approaches to providing passenger transportation in low density cities : the case of Council Bluffs, Iowa

DOT National Transportation Integrated Search

1997-09-01

This study explores transportation alternatives for Council Bluffs. The intention is to explore alternatives that may potentially prove viable for other small cities faced with scattered development patterns and limited population density. The study ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wellman, Dawn M.; Freshley, Mark D.; Truex, Michael J.

Current requirements for site remediation and closure are standards-based and are often overly conservative, costly, and in some cases, technically impractical to achieve. Use of risk-informed alternate endpoints provide a means to achieve remediation goals that are permitted by regulations and are protective of human health and the environment. Alternate endpoints enable establishing a path for cleanup that may include intermediate remedial milestones and transition points and/or regulatory alternatives to standards-based remediation. A framework is presented that is centered around developing and refining conceptual models in conjunction with assessing risks and potential endpoints as part of a system-based assessment thatmore » integrates site data with scientific understanding of processes that control the distribution and transport of contaminants in the subsurface and pathways to receptors. This system based assessment and subsequent implementation of the remediation strategy with appropriate monitoring are targeted at providing a holistic approach to addressing risks to human health and the environment. This holistic approach also enables effective predictive analysis of contaminant behavior to provide defensible criteria and data for making long-term decisions. Developing and implementing an alternate endpoint-based approach for remediation and waste site closure presents a number of challenges and opportunities. Categories of these challenges include scientific and technical, regulatory, institutional, and budget and resource allocation issues. Opportunities exist for developing and implementing systems-based approaches with respect to supportive characterization, monitoring, predictive modeling, and remediation approaches.« less

Alternative approaches for vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status

EPA Science Inventory

The need for alternative approaches to the use of vertebrate animals for hazard assessing chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate or...

An Advanced Multiple Alternatives Modeling Formulation for Determining Graduated Fiscal Support Strategies for Operational and Planned Educational Programs.

ERIC Educational Resources Information Center

Wholeben, Brent Edward

A rationale is presented for viewing the decision-making process inherent in determining budget reductions for educational programs as most effectively modeled by a graduated funding approach. The major tenets of the graduated budget reduction approach to educational fiscal policy include the development of multiple alternative reduction plans, or…

Economics in the School Curriculum.

ERIC Educational Resources Information Center

Brenneke, Judith Staley; Soper, John C.

1987-01-01

Various approaches to developing and implementing economics curricula are explored, including positive and normative economics, teacher-developed informal curriculum, district-developed formal curriculum, "outside" curriculum, the infusion approach, or as a separate course. It is suggested that a "blend" of the alternatives may optimize the…

Clustering and group selection of multiple criteria alternatives with application to space-based networks.

PubMed

Malakooti, Behnam; Yang, Ziyong

2004-02-01

In many real-world problems, the range of consequences of different alternatives are considerably different. In addition, sometimes, selection of a group of alternatives (instead of only one best alternative) is necessary. Traditional decision making approaches treat the set of alternatives with the same method of analysis and selection. In this paper, we propose clustering alternatives into different groups so that different methods of analysis, selection, and implementation for each group can be applied. As an example, consider the selection of a group of functions (or tasks) to be processed by a group of processors. The set of tasks can be grouped according to their similar criteria, and hence, each cluster of tasks to be processed by a processor. The selection of the best alternative for each clustered group can be performed using existing methods; however, the process of selecting groups is different than the process of selecting alternatives within a group. We develop theories and procedures for clustering discrete multiple criteria alternatives. We also demonstrate how the set of alternatives is clustered into mutually exclusive groups based on 1) similar features among alternatives; 2) ideal (or most representative) alternatives given by the decision maker; and 3) other preferential information of the decision maker. The clustering of multiple criteria alternatives also has the following advantages. 1) It decreases the set of alternatives to be considered by the decision maker (for example, different decision makers are assigned to different groups of alternatives). 2) It decreases the number of criteria. 3) It may provide a different approach for analyzing multiple decision makers problems. Each decision maker may cluster alternatives differently, and hence, clustering of alternatives may provide a basis for negotiation. The developed approach is applicable for solving a class of telecommunication networks problems where a set of objects (such as routers, processors, or intelligent autonomous vehicles) are to be clustered into similar groups. Objects are clustered based on several criteria and the decision maker's preferences.

Team Approach for Occupational and Useful Career Education--Humanized.

ERIC Educational Resources Information Center

Stone, Naomi; Spence, Patricia

Developed for teachers seeking an alternative classroom approach that develops students' life skills, this manual introduces, describes, and facilitates the implementation of TOUCH (Team Approach for Occupational and Useful Career Education--Humanized). Parts 1 and 2 introduce and define TOUCH as an instructional process which uses subject area…

Whose Development? Salvaging the Concept of Development within a Sociocultural Approach to Education

ERIC Educational Resources Information Center

Matusov, Eugene; DePalma, Renee; Drye, Stephanie

2007-01-01

The concept of development is currently under revision in education and psychology. In this essay, Eugene Matusov, Renee DePalma, and Stephanie Drye examine a traditional notion of development and provide an alternative sociocultural view. As educators working within a sociocultural approach to learning, development, and education, the authors see…

Alternatives to antibiotics-a pipeline portfolio review.

PubMed

Czaplewski, Lloyd; Bax, Richard; Clokie, Martha; Dawson, Mike; Fairhead, Heather; Fischetti, Vincent A; Foster, Simon; Gilmore, Brendan F; Hancock, Robert E W; Harper, David; Henderson, Ian R; Hilpert, Kai; Jones, Brian V; Kadioglu, Aras; Knowles, David; Ólafsdóttir, Sigríður; Payne, David; Projan, Steve; Shaunak, Sunil; Silverman, Jared; Thomas, Christopher M; Trust, Trevor J; Warn, Peter; Rex, John H

2016-02-01

Antibiotics have saved countless lives and enabled the development of modern medicine over the past 70 years. However, it is clear that the success of antibiotics might only have been temporary and we now expect a long-term and perhaps never-ending challenge to find new therapies to combat antibiotic-resistant bacteria. A broader approach to address bacterial infection is needed. In this Review, we discuss alternatives to antibiotics, which we defined as non-compound approaches (products other than classic antibacterial agents) that target bacteria or any approaches that target the host. The most advanced approaches are antibodies, probiotics, and vaccines in phase 2 and phase 3 trials. This first wave of alternatives to antibiotics will probably best serve as adjunctive or preventive therapies, which suggests that conventional antibiotics are still needed. Funding of more than £1·5 billion is needed over 10 years to test and develop these alternatives to antibiotics. Investment needs to be partnered with translational expertise and targeted to support the validation of these approaches in phase 2 trials, which would be a catalyst for active engagement and investment by the pharmaceutical and biotechnology industry. Only a sustained, concerted, and coordinated international effort will provide the solutions needed for the future. Copyright © 2016 Elsevier Ltd. All rights reserved.

Sensitivity Analysis of Multicriteria Choice to Changes in Intervals of Value Tradeoffs

NASA Astrophysics Data System (ADS)

Podinovski, V. V.

2018-03-01

An approach to sensitivity (stability) analysis of nondominated alternatives to changes in the bounds of intervals of value tradeoffs, where the alternatives are selected based on interval data of criteria tradeoffs is proposed. Methods of computations for the analysis of sensitivity of individual nondominated alternatives and the set of such alternatives as a whole are developed.

Animal use replacement, reduction, and refinement: development of an integrated testing strategy for bioconcentration of chemicals in fish.

PubMed

de Wolf, Watze; Comber, Mike; Douben, Peter; Gimeno, Sylvia; Holt, Martin; Léonard, Marc; Lillicrap, Adam; Sijm, Dick; van Egmond, Roger; Weisbrod, Anne; Whale, Graham

2007-01-01

When addressing the use of fish for the environmental safety of chemicals and effluents, there are many opportunities for applying the principles of the 3Rs: Reduce, Refine, and Replace. The current environmental regulatory testing strategy for bioconcentration and secondary poisoning has been reviewed, and alternative approaches that provide useful information are described. Several approaches can be used to reduce the number of fish used in the Organization for Economic Cooperation and Development (OECD) Test Guideline 305, including alternative in vivo test methods such as the dietary accumulation test and the static exposure approach. The best replacement approach would seem to use read-across, chemical grouping, and quantitative structure-activity relationships with an assessment of the key processes in bioconcentration: Adsorption, distribution, metabolism, and excretion. Biomimetic extraction has particular usefulness in addressing bioavailable chemicals and is in some circumstances capable of predicting uptake. Use of alternative organisms such as invertebrates should also be considered. A single cut-off value for molecular weight and size beyond which no absorption will take place cannot be identified. Recommendations for their use in bioaccumulative (B) categorization schemes are provided. Assessment of biotransformation with in vitro assays and in silico approaches holds significant promise. Further research is needed to identify their variability and confidence limits and the ways to use this as a basis to estimate bioconcentration factors. A tiered bioconcentration testing strategy has been developed taking account of the alternatives discussed.

Commentary: The failure of social inclusion: an alternative approach through community development.

PubMed

Mandiberg, James M

2012-01-01

Mental health services have not resulted in broad-based inclusion of people with psychiatric disabilities. Rather, many maintain their community lives only through the support of formal mental health services, which is financially unsustainable given current fiscal realities. Fundamental assumptions about sources of support for everyday life need to be reassessed. The economic and social development of the mental health recovery community provides an alternative approach to helping people maintain successful community lives and shifts some of the supports from mental health providers to business infrastructure within the mental health recovery identity community. Some projects that have utilized this approach, such as business incubators and work integration social enterprises, are described, and community development that builds on concepts of recovery is discussed.

Valley Fill Design and Construction Alternatives to Improve Ecological Performance

EPA Pesticide Factsheets

This presentation discusses; current challenges, comprehensive approaches, BMPs, the Middlefork Development, the Guy Cove project, and a path forward when looking at construction alternatives to improve the ecological performance of valley fills.

Alternative approaches to forestry research evaluation: an assessment.

Treesearch

Pamela J. Jakes; Earl C. Leatherberry

1986-01-01

Reviews research evaluation techniques in a variety of fields an assesses the usefulness of various approaches or combinations of approaches for forestry research evaluation. Presents an evaluation framework that will help users develop an approach suitable for their specific problem.

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.

PubMed

Hamm, Jon; Sullivan, Kristie; Clippinger, Amy J; Strickland, Judy; Bell, Shannon; Bhhatarai, Barun; Blaauboer, Bas; Casey, Warren; Dorman, David; Forsby, Anna; Garcia-Reyero, Natàlia; Gehen, Sean; Graepel, Rabea; Hotchkiss, Jon; Lowit, Anna; Matheson, Joanna; Reaves, Elissa; Scarano, Louis; Sprankle, Catherine; Tunkel, Jay; Wilson, Dan; Xia, Menghang; Zhu, Hao; Allen, David

2017-06-01

Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. Workshop attendees included representatives from international regulatory agencies, academia, nongovernmental organizations, and industry. Resources identified as necessary for meaningful progress in implementing alternatives included compiling and making available high-quality reference data, training on use and interpretation of in vitro and in silico approaches, and global harmonization of testing requirements. Attendees particularly noted the need to characterize variability in reference data to evaluate new approaches. They also noted the importance of understanding the mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. Workshop breakout groups explored different approaches to reducing or replacing animal use for acute toxicity testing, with each group crafting a roadmap and strategy to accomplish near-term progress. The workshop steering committee has organized efforts to implement the recommendations of the workshop participants. Copyright © 2017 Elsevier Ltd. All rights reserved.

Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing

PubMed Central

Hamm, Jon; Sullivan, Kristie; Clippinger, Amy J.; Strickland, Judy; Bell, Shannon; Bhhatarai, Barun; Blaauboer, Bas; Casey, Warren; Dorman, David; Forsby, Anna; Garcia-Reyero, Natàlia; Gehen, Sean; Graepel, Rabea; Hotchkiss, Jon; Lowit, Anna; Matheson, Joanna; Reaves, Elissa; Scarano, Louis; Sprankle, Catherine; Tunkel, Jay; Wilson, Dan; Xia, Menghang; Zhu, Hao; Allen, David

2017-01-01

Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. Workshop attendees included representatives from international regulatory agencies, academia, nongovernmental organizations, and industry. Resources identified as necessary for meaningful progress in implementing alternatives included compiling and making available high-quality reference data, training on use and interpretation of in vitro and in silico approaches, and global harmonization of testing requirements. Attendees particularly noted the need to characterize variability in reference data to evaluate new approaches. They also noted the importance of understanding the mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. Workshop breakout groups explored different approaches to reducing or replacing animal use for acute toxicity testing, with each group crafting a roadmap and strategy to accomplish near-term progress. The workshop steering committee has organized efforts to implement the recommendations of the workshop participants. PMID:28069485

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment.

PubMed

Scholz, Stefan; Sela, Erika; Blaha, Ludek; Braunbeck, Thomas; Galay-Burgos, Malyka; García-Franco, Mauricio; Guinea, Joaquin; Klüver, Nils; Schirmer, Kristin; Tanneberger, Katrin; Tobor-Kapłon, Marysia; Witters, Hilda; Belanger, Scott; Benfenati, Emilio; Creton, Stuart; Cronin, Mark T D; Eggen, Rik I L; Embry, Michelle; Ekman, Drew; Gourmelon, Anne; Halder, Marlies; Hardy, Barry; Hartung, Thomas; Hubesch, Bruno; Jungmann, Dirk; Lampi, Mark A; Lee, Lucy; Léonard, Marc; Küster, Eberhard; Lillicrap, Adam; Luckenbach, Till; Murk, Albertinka J; Navas, José M; Peijnenburg, Willie; Repetto, Guillermo; Salinas, Edward; Schüürmann, Gerrit; Spielmann, Horst; Tollefsen, Knut Erik; Walter-Rohde, Susanne; Whale, Graham; Wheeler, James R; Winter, Matthew J

2013-12-01

Tests with vertebrates are an integral part of environmental hazard identification and risk assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed additives and effluents. These tests raise ethical and economic concerns and are considered as inappropriate for assessing all of the substances and effluents that require regulatory testing. Hence, there is a strong demand for replacement, reduction and refinement strategies and methods. However, until now alternative approaches have only rarely been used in regulatory settings. This review provides an overview on current regulations of chemicals and the requirements for animal tests in environmental hazard and risk assessment. It aims to highlight the potential areas for alternative approaches in environmental hazard identification and risk assessment. Perspectives and limitations of alternative approaches to animal tests using vertebrates in environmental toxicology, i.e. mainly fish and amphibians, are discussed. Free access to existing (proprietary) animal test data, availability of validated alternative methods and a practical implementation of conceptual approaches such as the Adverse Outcome Pathways and Integrated Testing Strategies were identified as major requirements towards the successful development and implementation of alternative approaches. Although this article focusses on European regulations, its considerations and conclusions are of global relevance. Copyright © 2013 Elsevier Inc. All rights reserved.

Comprehensive Reform for Urban High Schools: A Talent Development Approach. Sociology of Education Series.

ERIC Educational Resources Information Center

Legters, Nettie E.; Balfanz, Robert; Jordan, Will J.; McPartland, James M.

This book offers an alternative to current reform efforts, the talent development approach, detailing organizational, curricular, and instructional strategies that provide practitioners with a blueprint for whole school reform. The book presents the story of what happened in urban high schools when this approach was implemented. There are eight…

A study of alternative methods for reclaiming oxygen from carbon dioxide and water by a solid-electrolyte process for spacecraft applications

NASA Technical Reports Server (NTRS)

1971-01-01

Two alternative technical approaches were studied for application of an electrochemical process using a solid oxide electrolyte (zirconia stabilized by yttria or scandia) to oxygen reclamation from carbon dioxide and water, for spacecraft life support systems. Among the topics considered are the advisability of proceeding to engineering prototype development and fabrication of a full scale model for the system concept, the optimum choice of method or approach to be carried into prototype development, and the technical problem areas which exist.

Alternative approaches to vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status

USGS Publications Warehouse

Lillicrap, Adam; Belanger, Scott; Burden, Natalie; Du Pasquier, David; Embry, Michelle; Halder, Marlies; Lampi, Mark; Lee, Lucy; Norberg-King, Teresa J.; Rattner, Barnett A.; Schirmer, Kristin; Thomas, Paul

2016-01-01

The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimized wherever possible. For some regulatory purposes, the use of vertebrate organisms for environmental risk assessments has been banned; in other situations, the number of organisms tested has been dramatically reduced or the severity of the procedure refined. However, there is still a long way to go to achieve a complete replacement of vertebrate organisms to generate environmental hazard data. The development of animal alternatives is based not just on ethical considerations but also on reducing the cost of performing vertebrate ecotoxicity tests and in some cases on providing better information aimed at improving environmental risk assessments. The present Focus article provides an overview of the considerable advances that have been made toward alternative approaches for ecotoxicity assessments over the last few decades.

Dropping the Other U: An Alternative Approach to U-Shaped Developmental Functions

ERIC Educational Resources Information Center

Brainerd, C. J.

2004-01-01

The aim of this article is to introduce readers to an alternative way of applying U-shaped functions to understand development, especially cognitive development. In classical developmental applications, age is the abscissa; that is, in the fundamental equation B = f(A), some behavioral variable (B) plots as a U-shaped or inverted U-shaped function…

Administrative Arrangements and a Curriculum for a University Training Programme for Adult Educators in Hong Kong.

ERIC Educational Resources Information Center

Shak Wai Han, Therese

The feasibility of introducing a university training program for adult education in Hong Kong was investigated. A system approach to needs assessment was developed based on six steps: (1) identify problems based on needs, (2) determine a solution and identify alternatives, (3) select solution strategies from among alternatives, (4) develop the…

The dynamical systems approach to numerical integration

NASA Astrophysics Data System (ADS)

Wisdom, Jack

2018-03-01

The dynamical systems approach to numerical integration is reviewed and extended. The new method is compared to some alternative methods based on the Lie series approach. The test problem is the motion of the outer planets. The algorithms developed using the dynamical systems approach perform well.

Parallels, How Many? Geometry Module for Use in a Mathematics Laboratory Setting.

ERIC Educational Resources Information Center

Brotherton, Sheila; And Others

This is one of a series of geometry modules developed for use by secondary students in a laboratory setting. This module was conceived as an alternative approach to the usual practice of giving Euclid's parallel postulate and then mentioning that alternate postulates would lead to an alternate geometry or geometries. Instead, the student is led…

Alternative Schools and Programs, Iowa. "Reaching Out to Help People." 1983-84 State Directory.

ERIC Educational Resources Information Center

Morley, Raymond E.; Clay, Helen I.

This directory was developed in response to requests for information on alternative programs for dropouts and potential dropouts. The scope of the dropout problem in Iowa is defined. Presented are definitions of dropout prevention alternative programs as well as a detailed account of useful prevention approaches. The directory includes needs…

Young Women and the Co-Construction of Leadership

ERIC Educational Resources Information Center

McNae, Rachel

2010-01-01

Purpose: Young women's leadership is an area frequently overlooked in educational leadership development. This paper aims to bring young women's voices into educational leadership conversations and illustrate an alternative approach to young women's leadership development. Design/methodology/approach: This qualitative action research study was…

Covariate Balance in Bayesian Propensity Score Approaches for Observational Studies

ERIC Educational Resources Information Center

Chen, Jianshen; Kaplan, David

2015-01-01

Bayesian alternatives to frequentist propensity score approaches have recently been proposed. However, few studies have investigated their covariate balancing properties. This article compares a recently developed two-step Bayesian propensity score approach to the frequentist approach with respect to covariate balance. The effects of different…

ReRouting biomedical innovation: observations from a mapping of the alternative research and development (R&D) landscape.

PubMed

Greenberg, Alexandra; Kiddell-Monroe, Rachel

2016-09-14

In recent years, the world has witnessed the tragic outcomes of multiple global health crises. From Ebola to high prices to antibiotic resistance, these events highlight the fundamental constraints of the current biomedical research and development (R&D) system in responding to patient needs globally.To mitigate this lack of responsiveness, over 100 self-identified "alternative" R&D initiatives, have emerged in the past 15 years. To begin to make sense of this panoply of initiatives working to overcome the constraints of the current system, UAEM began an extensive, though not comprehensive, mapping of the alternative biomedical R&D landscape. We developed a two phase approach: (1) an investigation, via the RE:Route Mapping, of both existing and proposed initiatives that claim to offer an alternative approach to R&D, and (2) evaluation of those initiatives to determine which are in fact achieving increased access to and innovation in medicines. Through phase 1, the RE:Route Mapping, we examined 81 initiatives that claim to redress the inequity perpetuated by the current system via one of five commonly recognized mechanisms necessary for truly alternative R&D.Preliminary analysis of phase 1 provides the following conclusions: 1. No initiative presents a completely alternative model of biomedical R&D. 2. The majority of initiatives focus on developing incentives for drug discovery. 3. The majority of initiatives focus on rare diseases or diseases of the poor and marginalized. 4. There is an increasing emphasis on the use of push, pull, pool, collaboration and open mechanisms alongside the concept of delinkage in alternative R&D. 5. There is a trend towards public funding and launching of initiatives by the Global South. Given the RE:Route Mapping's inevitable limitations and the assumptions made in its methodology, it is not intended to be the final word on a constantly evolving and complex field; however, its findings are significant. The Mapping's value lies in its timely and unique insight into the importance of ongoing efforts to develop a new global framework for biomedical R&D. As we progress to phase 2, an evaluation tool for initiatives focused on identifying which approaches have truly achieved increased innovation and access for patients, we aim to demonstrate that there are a handful of initiatives which represent some, but not all, of the building blocks for a new approach to R&D.Through this mapping and our forthcoming evaluation, UAEM aims to initiate an evidence-based conversation around a truly alternative biomedical R&D model that serves people rather than profits.

A Political Philosophy Approach to Teaching American Politics.

ERIC Educational Resources Information Center

Bailey, Kevin E.

1982-01-01

Suggests an alternative to the civic training, political indoctrination, and descriptive presentation approaches used to teaching American government courses. Recommends a political philosophy approach within a framework of elite theory to help students develop a critical perspective on American politics. (DMM)

2016 TSRC Summer School on Fundamental Science for Alternative Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batista, Victor S.

The 2016 TSRC Summer School on Fundamental Science for Alternative Energy introduced principles, methods, and approaches relevant to the design of molecular transformations, energy transduction, and current applications for alternative energy. Energy and environment are likely to be key themes that will dominate the way science and engineering develop over the next few decades. Only an interdisciplinary approach with a team-taught structure as presented at the 2016 TSRC Summer School can be expected to succeed in the face of problems of such difficulty. The course inspired a new generation of 24 graduate students and 2 post-docs to continue work inmore » the field, or at least to have something of an insider's point of view as the field develops in the next few decades.« less

A novel training approach to activate alternative behaviors for smoking in depressed smokers.

PubMed

Kopetz, Catalina; MacPherson, Laura; Mitchell, Avery D; Houston-Ludlam, Alexandra N; Wiers, Reinout W

2017-02-01

The current research developed and tested a novel training strategy to alter the implicit associations between alternative behaviors to smoking and negative affect, and explored its effects on depressive symptoms and on smoking behavior as part of a quit attempt. Using a joystick, participants identified as smokers with depressive symptoms were trained to approach alternative behaviors to smoking in the context of negative affect. Specifically, in the experimental condition, participants were trained to avoid smoking-related targets and to approach alternative activities. In the control condition, participants pushed and pulled an equal amount of smoking and alternative activity-related targets. Compared with the participants in the control condition, those in the experimental condition showed an increase in the accessibility of the alternative activity relative to smoking and a decrease in depressive symptoms. Smoking outcomes did not differ significantly across the 2 conditions. Taken together these results indicate that the value of alternative behaviors to smoking can be modified in the lab without participants' conscious intentions with implications for depressive symptomatology. Future research is required to explore the impact of such training on smoking outcomes. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets.

PubMed

Vasaikar, Suhas; Bhatia, Pooja; Bhatia, Partap G; Chu Yaiw, Koon

2016-11-21

In the past decade, it was observed that the relationship between the emerging New Molecular Entities and the quantum of R&D investment has not been favorable. There might be numerous reasons but few studies stress the introduction of target based drug discovery approach as one of the factors. Although a number of drugs have been developed with an emphasis on a single protein target, yet identification of valid target is complex. The approach focuses on an in vitro single target, which overlooks the complexity of cell and makes process of validation drug targets uncertain. Thus, it is imperative to search for alternatives rather than looking at success stories of target-based drug discovery. It would be beneficial if the drugs were developed to target multiple components. New approaches like reverse engineering and translational research need to take into account both system and target-based approach. This review evaluates the strengths and limitations of known drug discovery approaches and proposes alternative approaches for increasing efficiency against treatment.

Farming Approaches for Greater Biodiversity, Livelihoods, and Food Security.

PubMed

Garibaldi, Lucas A; Gemmill-Herren, Barbara; D'Annolfo, Raffaele; Graeub, Benjamin E; Cunningham, Saul A; Breeze, Tom D

2017-01-01

Scientists and policy-makers globally are calling for alternative approaches to conventional intensification of agriculture that enhance ecosystem services provided by biodiversity. The evidence reviewed here suggests that alternative approaches can achieve high crop yields and profits, but the performance of other socioeconomic indicators (as well as long-term trends) is surprisingly poorly documented. Consequently, the implementation of conventional intensification and the discussion of alternative approaches are not based on quantitative evidence of their simultaneous ecological and socioeconomic impacts across the globe. To close this knowledge gap, we propose a participatory assessment framework. Given the impacts of conventional intensification on biodiversity loss and greenhouse gas emissions, such evidence is urgently needed to direct science-policy initiatives, such as the United Nations (UN) 2030 Agenda for Sustainable Development. Copyright © 2016 Elsevier Ltd. All rights reserved.

Harnessing the Power of Learning Management Systems: An E-Learning Approach for Professional Development.

PubMed

White, Meagan; Shellenbarger, Teresa

E-learning provides an alternative approach to traditional professional development activities. A learning management system may help nursing professional development practitioners deliver content more efficiently and effectively; however, careful consideration is needed during planning and implementation. This article provides essential information in the selection and use of a learning management system for professional development.

The initial instability and finite-amplitude stability of alternate bars in straight channels

USGS Publications Warehouse

Nelson, J.M.

1990-01-01

The initial instability and fully developed stability of alternate bars in straight channels are investigated using linearized and nonlinear analyses. The fundamental instability leading to these features is identified through a linear stability analysis of the equations governing the flow and sediment transport fields. This instability is explained in terms of topographically induced steering of the flow and the associated pattern of erosion and deposition on the bed. While the linear theory is useful for examining the instability mechanism, this approach is shown to yield relatively little information about well-developed alternate bars and, specifically, the linear analysis is shown to yield poor predictions of the fully developed bar wavelength. A fully nonlinear approach is presented that permits computation of the evolution of these bed features from an initial perturbation to their fully developed morphology. This analysis indicates that there is typically substantial elongation of the bar wavelength during the evolution process, a result that is consistent with observations of bar development in flumes and natural channels. The nonlinear approach demonstrates that the eventual stability of these features is a result of the interplay between topographic steering effects, secondary flow production as a result of streamline curvature, and gravitationally induced modifications of sediment fluxes over a sloping bed. ?? 1990.

Can microbes economically remove sulfur

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fox, J.L.

Researchers have reported that refiners who now rely on costly physic-chemical procedures to desulfurize petroleum will soon have an alternative microbial-enzyme-based approach to this process. This new approach is still under development and considerable number chemical engineering problems need to be solved before this process is ready for large-scale use. This paper reviews the several research projects dedicated solving the problems that keep a biotechnology-based alternative from competing with chemical desulfurization.

Evolution of alternative methodologies of scorpion antivenoms production.

PubMed

Carmo, A O; Chatzaki, M; Horta, C C R; Magalhães, B F; Oliveira-Mendes, B B R; Chávez-Olórtegui, C; Kalapothakis, E

2015-04-01

Scorpionism represents a serious public health problem resulting in the death of children and debilitated individuals. Scorpion sting treatment employs various strategies including the use of specific medicines such as antiserum, especially for patients with severe symptoms. In 1909 Charles Todd described the production of an antiserum against the venom of the scorpion Buthus quinquestriatus. Based on Todd's work, researchers worldwide began producing antiserum using the same approach i.e., immunization of horses with crude venom as antigen. Despite achieving satisfactory results using this approach, researchers in this field have developed alternative approaches for the production of scorpion antivenom serum. In this review, we describe the work published by experts in toxinology to the development of scorpion venom antiserum. Methods and results describing the use of specific antigens, detoxified venom or toxins, purified toxins and or venom fractions, native toxoids, recombinant toxins, synthetic peptides, monoclonal and recombinant antibodies, and alternative animal models are presented. Copyright © 2015 Elsevier Ltd. All rights reserved.

Bridge approach slabs for Missouri DOT looking at alternative and cost efficient approaches.

DOT National Transportation Integrated Search

2010-12-01

The objective of this project is to develop innovative and cost effective structural solutions for the construction of : both new and replacement deteriorated Bridge Approach Slabs (BAS). A cost study and email survey was performed to identify : stat...

SUSTAINABLE MANAGEMENT APPROACHES AND REVITALIZATION TOOLS-ELECTRONIC (SMARTE): OVERVIEW AND DEMONSTRATION FOR FINAL PHASE 3 CONFERENCE

EPA Science Inventory

The U.S. contingent of the U.S.-German Bilateral Working Group is developing Sustainable Management Approaches and Revitalization Tools-electronic (SMARTe). SMARTe is a web-based, decision support system designed to assist stakeholders in developing and evaluating alternative reu...

Alternative approaches to vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status.

PubMed

Lillicrap, Adam; Belanger, Scott; Burden, Natalie; Pasquier, David Du; Embry, Michelle R; Halder, Marlies; Lampi, Mark A; Lee, Lucy; Norberg-King, Teresa; Rattner, Barnett A; Schirmer, Kristin; Thomas, Paul

2016-11-01

The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimized wherever possible. For some regulatory purposes, the use of vertebrate organisms for environmental risk assessments has been banned; in other situations, the number of organisms tested has been dramatically reduced or the severity of the procedure refined. However, there is still a long way to go to achieve a complete replacement of vertebrate organisms to generate environmental hazard data. The development of animal alternatives is based not just on ethical considerations but also on reducing the cost of performing vertebrate ecotoxicity tests and in some cases on providing better information aimed at improving environmental risk assessments. The present Focus article provides an overview of the considerable advances that have been made toward alternative approaches for ecotoxicity assessments over the last few decades. Environ Toxicol Chem 2016;35:2637-2646. © 2016 SETAC. © 2016 SETAC.

Model fit evaluation in multilevel structural equation models

PubMed Central

Ryu, Ehri

2014-01-01

Assessing goodness of model fit is one of the key questions in structural equation modeling (SEM). Goodness of fit is the extent to which the hypothesized model reproduces the multivariate structure underlying the set of variables. During the earlier development of multilevel structural equation models, the “standard” approach was to evaluate the goodness of fit for the entire model across all levels simultaneously. The model fit statistics produced by the standard approach have a potential problem in detecting lack of fit in the higher-level model for which the effective sample size is much smaller. Also when the standard approach results in poor model fit, it is not clear at which level the model does not fit well. This article reviews two alternative approaches that have been proposed to overcome the limitations of the standard approach. One is a two-step procedure which first produces estimates of saturated covariance matrices at each level and then performs single-level analysis at each level with the estimated covariance matrices as input (Yuan and Bentler, 2007). The other level-specific approach utilizes partially saturated models to obtain test statistics and fit indices for each level separately (Ryu and West, 2009). Simulation studies (e.g., Yuan and Bentler, 2007; Ryu and West, 2009) have consistently shown that both alternative approaches performed well in detecting lack of fit at any level, whereas the standard approach failed to detect lack of fit at the higher level. It is recommended that the alternative approaches are used to assess the model fit in multilevel structural equation model. Advantages and disadvantages of the two alternative approaches are discussed. The alternative approaches are demonstrated in an empirical example. PMID:24550882

Alternative financial institutions? Sustainability, development, social reproduction, and gender analysis.

PubMed

Kidder, T

1999-08-01

This paper proposes a conceptual framework for alternative financial institutions in Nicaragua. The article includes a discussion on innovative services and policies, which differentiate CARUNA (National Savings and Credit Cooperative ¿Caja Rural¿), and other financial institutions from conventional banks. It further examines theories that have altered the way development practitioners think about the economy, poverty reduction, and the positions of men and women in the society. These theories are the feminist economic theory and alternative development theories. Specific ways to incorporate the concepts of alternative and feminist economic theories in the design of financial institutions include open credit, savings, and remittance mechanisms, and coordinating councils. The gender analysis approach was used to evaluate the design of financial institutions.

Alternative Strategies for Funding a General Dentistry Residency Program.

ERIC Educational Resources Information Center

Kralewski, John E.; Wiggins, Carla

1987-01-01

Three alternative program funding approaches used in other professions are examined: (1) the reorientation of selected dental schools toward graduate education, (2) emphasizing and marketing the service aspects of the programs, and (3) developing education programs as in-house training for large organizations. (MSE)

Advancing practice relating to SEA alternatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

González, Ainhoa, E-mail: agonzal@tcd.ie; Thérivel, Riki, E-mail: levett-therivel@phonecoop.coop; Fry, John, E-mail: john.fry@ucd.ie

Developing and assessing alternatives is a key and central stage to Strategic Environmental Assessment (SEA). However, research has repeatedly reported this stage as one of the most poorly undertaken aspects of the SEA process. Current practice limitations include belated consideration of reasonable alternatives, narrow scope of alternatives that often include unrealistic or retrofitted options, limited stakeholder and public involvement in their identification, assessment and selection, lack of systematic approaches to their assessment and comparison, and inadequate reporting of the ‘storyline’ on how they were identified, what the potential impacts are and why the preferred alternative was selected. These issues havemore » resulted in objections and judicial reviews. On the positive side, a number of good practice case studies enable extraction of key lessons and formulation of a set of general recommendations to advance practice in SEA alternatives. In this paper, practical guidance on the identification and development of alternatives, their assessment and comparison, selection of the preferred option, and documentation of the process and the reasons for selection is provided and discussed to frame good practice approaches. - Highlights: • Alternatives are one of the most poorly completed aspects of Strategic Environmental Assessment. • Current practice limitations need to be addressed to enhance SEA effectiveness. • A set of recommendations are extracted from good practice case studies. • These recommendations can be applied across jurisdictions and sectors and tailored as necessary.« less

Democracy and sustainable development--what is the alternative to cost-benefit analysis?

PubMed

Söderbaum, Peter

2006-04-01

Cost-benefit analysis (CBA) is part of neoclassical economics, a specific paradigm, or theoretical perspective. In searching for alternatives to CBA, competing theoretical frameworks in economics appear to be a natural starting point. Positional analysis (PA) as an alternative to CBA is built on institutional theory and a different set of assumptions about human beings, organizations, markets, etc. Sustainable development (SD) is a multidimensional concept that includes social and ecological dimensions in addition to monetary aspects. If the political commitment to SD in the European Union and elsewhere is taken seriously, then approaches to decision making should be chosen that 1st open the door for multidimensional analysis rather than close it. Sustainable development suggests a direction for development in a broad sense but is still open to different interpretations. Each such interpretation is political in kind, and a 2nd criterion for judging different approaches is whether they are ideologically open rather than closed. Although methods for decision making have traditionally been connected with mathematical objective functions and optimization, the purpose of PA is to illuminate a decision situation in a many-sided way with respect to possibly relevant ideological orientations, alternatives, and consequences. Decisions are understood in terms of matching the ideological orientation of each decision maker with the expected effects profile of each alternative considered. Appropriateness and pattern recognition are other concepts in understanding this process.

Instructional Systems Study, Electronics Technology.

ERIC Educational Resources Information Center

Waukesha County Technical Inst., Waukesha, WI.

Because of shortcomings in the traditional approach to instruction and learning at Waukesha County Technical Institute in Wisconsin, this research was conducted to determine the effectiveness of an alternate approach to instruction in electronics technology. The "Closed Loop Systems Approach to Instruction" developed for this study was derived…

Cerebral Ketone Metabolism During Development and Injury

PubMed Central

Prins, Mayumi L.

2011-01-01

Cerebral metabolism of ketones is a normal part of the process of brain development. While the mature brain relies on glucose as a primary fuel source, metabolism of ketone bodies remains an alternative energy source under conditions of starvation. The neuroprotective properties of brain ketone metabolism make this alternative substrate a viable therapeutic option for various pathologies. Since the ability to revert to utilizing ketones as an alternative substrate is greatest in the younger post-weaned brain, this particular therapeutic approach remains an untapped resource particularly for pediatric pathological conditions. PMID:22104087

Evaluation of an individualized sanctioning program for DWI offenders

DOT National Transportation Integrated Search

1998-12-01

Evaluates two different approaches to sentencing Driving While Intoxicated (DWI) offenders in Georgia. One approach (called the "Todd Program" after the judge who developed it) imposed individually-tailored combinations of traditional and alternative...

An illustrative analysis of technological alternatives for satellite communications

NASA Technical Reports Server (NTRS)

Metcalfe, M. R.; Cazalet, E. G.; North, D. W.

1979-01-01

The demand for satellite communications services in the domestic market is discussed. Two approaches to increasing system capacity are the expansion of service into frequencies presently allocated but not used for satellite communications, and the development of technologies that provide a greater level of service within the currently used frequency bands. The development of economic models and analytic techniques for evaluating capacity expansion alternatives such as these are presented. The satellite orbit spectrum problem, and also outlines of some suitable analytic approaches are examined. Illustrative analysis of domestic communications satellite technology options for providing increased levels of service are also examined. The analysis illustrates the use of probabilities and decision trees in analyzing alternatives, and provides insight into the important aspects of the orbit spectrum problem that would warrant inclusion in a larger scale analysis.

ETO - ENGINEERING TRADE-OFFS (SYSTEMS ANALYSIS BRANCH, SUSTAINABLE TECHNOLOGY DIVISION, NRMRL)

EPA Science Inventory

The ETO - Engineering Trade-Offs program is to develop a new, integrated decision-making approach to compare/contrast two or more states of being: a benchmark and an alternative, a change in a production process, alternative processes or products. ETO highlights the difference in...

In Progress: Reports of New Approaches in Medical Education. Peer-Reviewed Collection of Reports on Innovative Approaches to Medical Education.

ERIC Educational Resources Information Center

Anderson, M. Brownell, Ed.

2002-01-01

Presents 24 articles describing innovative efforts in medical education in the areas of faculty development; developing skills as residents; and culture, ethics, spirituality, complementary, and alternative medicine. Each report includes an objective, description, discussion, and contact information for inquiries. (EV)

Visual preference and ecological assessments for designed alternative brownfield rehabilitations.

PubMed

Lafortezza, Raffaele; Corry, Robert C; Sanesi, Giovanni; Brown, Robert D

2008-11-01

This paper describes an integrative method for quantifying, analyzing, and comparing the effects of alternative rehabilitation approaches with visual preference. The method was applied to a portion of a major industrial area located in southern Italy. Four alternative approaches to rehabilitation (alternative designs) were developed and analyzed. The scenarios consisted of the cleanup of the brownfields plus: (1) the addition of ground cover species; (2) the addition of ground cover species and a few trees randomly distributed; (3) the addition of ground cover species and a few trees in small groups; and (4) the addition of ground cover species and several trees in large groups. The approaches were analyzed and compared to the baseline condition through the use of cost-surface modeling (CSM) and visual preference assessment (VPA). Statistical results showed that alternatives that were more ecologically functional for forest bird species dispersal were also more visually preferable. Some differences were identified based on user groups and location of residence. The results of the study are used to identify implications for enhancing both ecological attributes and visual preferences of rehabilitating landscapes through planning and design.

Predicting the Consequences of Workload Management Strategies with Human Performance Modeling

NASA Technical Reports Server (NTRS)

Mitchell, Diane Kuhl; Samma, Charneta

2011-01-01

Human performance modelers at the US Army Research Laboratory have developed an approach for establishing Soldier high workload that can be used for analyses of proposed system designs. Their technique includes three key components. To implement the approach in an experiment, the researcher would create two experimental conditions: a baseline and a design alternative. Next they would identify a scenario in which the test participants perform all their representative concurrent interactions with the system. This scenario should include any events that would trigger a different set of goals for the human operators. They would collect workload values during both the control and alternative design condition to see if the alternative increased workload and decreased performance. They have successfully implemented this approach for military vehicle. designs using the human performance modeling tool, IMPRINT. Although ARL researches use IMPRINT to implement their approach, it can be applied to any workload analysis. Researchers using other modeling and simulations tools or conducting experiments or field tests can use the same approach.

Measuring the Impact of an Alternative Approach to School Bullying

ERIC Educational Resources Information Center

Domino, Meg

2013-01-01

Background: National estimates of middle school bullying approximate 40%, making it the leading form of school violence. Meta-analysis of conventional anti-bullying efforts have shown mixed results, averaging small reductions in bullying behavior. Social-Emotional Learning and PositiveYouth Development provide a theory-driven alternative for…

Anaerobic soil disinfestation: a chemical-independent approach to pre-plant control of plant pathogens

USDA-ARS?s Scientific Manuscript database

Due to increasing regulations and restrictions, there is an urgent need to develop effective alternatives to chemical-dependent soil fumigation control of soilborne pests and pathogens. Anaerobic soil disinfestation (ASD) is one such alternative showing great promise against a number of soilborne pa...

Brief Report: Alternative Approaches to the Development of Effective Treatments for Autism.

ERIC Educational Resources Information Center

Rimland, Bernard; Baker, Sidney M.

1996-01-01

The most widely used "alternative" biomedical treatments for autism are reviewed, including: nutritional supplements, especially megadose vitamin B6 and magnesium; treatment of food allergies and intolerances; treatment of microbial infections; and treatment of immune system dysfunction. The Defeat Autism Now! project is briefly…

Alternative Approach to Teaching Veterinary Anatomy: A Progress Report

ERIC Educational Resources Information Center

Hullinger, Ronald; Render, Gary F.

1975-01-01

Students in microscopic anatomy at Purdue University School of Veterinary Medicine selected a self-directed or teacher-directed approach to the course. Adoption of the experimental approach described here increased faculty time for evaluating student progress but was supportive of student development particularly in cognitive skills and affective…

Deep Reconditioning Testing for near Earth Orbits

NASA Technical Reports Server (NTRS)

Betz, F. E.; Barnes, W. L.

1984-01-01

The problems and benefits of deep reconditioning to near Earth orbit missions with high cycle life and shallow discharge depth requirements is discussed. A simple battery level approach to deep reconditioning of nickel cadmium batteries in near Earth orbit is considered. A test plan was developed to perform deep reconditioning in direct comparison with an alternative trickle charge approach. The results demonstrate that the deep reconditioning procedure described for near Earth orbit application is inferior to the alternative of trickle charging.

Occupational medicine: toward a worker/patient empowerment approach to occupational illness.

PubMed

Lax, Michael B

2002-01-01

Clinicians practicing occupational medicine are increasingly confronted with patients who have complex illnesses with chronic nonspecific symptoms. Most clinicians use the traditional tools of biomedicine to diagnose and treat the illness, determine etiology, and assess disability. This article argues that the biomedical approach is inadequate to effectively evaluate and treat occupational illness. After reviewing several critiques of biomedicine, including biopsychosocial, feminist, class, and critical theory/postmodern perspectives, the author offers an alternative approach that builds on aspects of these perspectives as well as the "popular education" work of Paulo Freire. Constraints on, and possibilities for, the development of an alternative approach that attempts to build patients' capacities for transformative action are explored.

Antimicrobial growth promoter use in livestock: a requirement to understand their modes of action to develop effective alternatives.

PubMed

Brown, Kirsty; Uwiera, Richard R E; Kalmokoff, Martin L; Brooks, Steve P J; Inglis, G Douglas

2017-01-01

Antimicrobial agents (AMAs) have been used in agriculture since the 1950s as growth-promoting agents [antimicrobial growth promoters (AGPs)]. They have provided benefits to the agricultural industry by increasing production efficiencies and maximising livestock health, yet the potential risks surrounding resistance to AMAs in medically important pathogenic bacteria have enhanced public and government scrutiny regarding AMA use in agriculture. Although it is recognised that AGP administration can select for resistance to AMAs in enteric bacteria of livestock, conclusive evidence showing a link between resistant bacteria from livestock and human health is lacking (e.g. transmission of resistant zoonotic pathogens). Livestock production output must be increased significantly due to the increase in global population, and thus the identification of non-AMA alternatives to AGP use is required. One strategy employed to identify alternatives to AGPs is an observational empirical methodology, but this approach has failed to deliver effective alternatives. A second approach is aimed at understanding the mechanisms involved in AGP function and developing alternatives that mimic the physiological responses to AGPs. New evidence indicates that AGP function is more complex than merely affecting enteric bacterial populations, and AGPs likely function by directly or indirectly modulating host responses such as the immune system. As such, a more comprehensive understanding of the mechanisms associated with AMA function as AGPs will facilitate the development of effective alternatives. Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Alternative approaches for vertebrate ecotoxicity tests in the ...

EPA Pesticide Factsheets

The need for alternative approaches to the use of vertebrate animals for hazard assessing chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimised wherever possible. For some regulatory purposes, the use of vertebrate organisms for environmental risk assessments (ERA) has even been banned, and in other situations the numbers of organisms tested has been dramatically reduced, or the severity of the procedure refined. However, there is still a long way to go to achieve replacement of vertebrate organisms to generate environmental hazard data. The development of animal alternatives is not just based on ethical considerations but also to reduce the cost of performing vertebrate ecotoxicity tests and in some cases to provide better information aimed at improving ERAs. The present focus paper provides an overview of the considerable advances that have been made towards alternative approaches for ecotoxicity assessments over the last few decades. The need for alternative approaches to the use of vertebrate animals for hazard assessing chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimised wherever possible. For some regulatory purposes, the use of vertebrate organi

Comparative Analysis of Sustainable Approaches and Systems for Scientific Data Stewardship

NASA Astrophysics Data System (ADS)

Downs, R. R.; Chen, R. S.

2012-12-01

Sustainable data systems are critical components of the cyberinfrastructure needed to provide long-term stewardship of scientific data, including Earth science data, throughout their entire life cycle. A variety of approaches may help ensure the sustainability of such systems, but these approaches must be able to survive the demands of competing priorities and decreasing budgets. Analyzing and comparing alternative approaches can identify viable aspects of each approach and inform decisions for developing, managing, and supporting the cyberinfrastructure needed to facilitate discovery, access, and analysis of data by future communities of users. A typology of sustainability approaches is proposed, and example use cases are offered for comparing the approaches over time. These examples demonstrate the potential strengths and weaknesses of each approach under various conditions and with regard to different objectives, e.g., open vs. limited access. By applying the results of these analyses to their particular circumstances, systems stakeholders can assess their options for a sustainable systems approach along with other metrics and identify alternative strategies to ensure the sustainability of the scientific data and information for which they are responsible. In addition, comparing sustainability approaches should inform the design of new systems and the improvement of existing systems to meet the needs for long-term stewardship of scientific data, and support education and workforce development efforts needed to ensure that the appropriate scientific and technical skills are available to operate and further develop sustainable cyberinfrastructure.

Evolving the Principles and Practice of Validation for New Alternative Approaches to Toxicity Testing.

PubMed

Whelan, Maurice; Eskes, Chantra

Validation is essential for the translation of newly developed alternative approaches to animal testing into tools and solutions suitable for regulatory applications. Formal approaches to validation have emerged over the past 20 years or so and although they have helped greatly to progress the field, it is essential that the principles and practice underpinning validation continue to evolve to keep pace with scientific progress. The modular approach to validation should be exploited to encourage more innovation and flexibility in study design and to increase efficiency in filling data gaps. With the focus now on integrated approaches to testing and assessment that are based on toxicological knowledge captured as adverse outcome pathways, and which incorporate the latest in vitro and computational methods, validation needs to adapt to ensure it adds value rather than hinders progress. Validation needs to be pursued both at the method level, to characterise the performance of in vitro methods in relation their ability to detect any association of a chemical with a particular pathway or key toxicological event, and at the methodological level, to assess how integrated approaches can predict toxicological endpoints relevant for regulatory decision making. To facilitate this, more emphasis needs to be given to the development of performance standards that can be applied to classes of methods and integrated approaches that provide similar information. Moreover, the challenge of selecting the right reference chemicals to support validation needs to be addressed more systematically, consistently and in a manner that better reflects the state of the science. Above all however, validation requires true partnership between the development and user communities of alternative methods and the appropriate investment of resources.

Idaho National Engineering and Environmental Laboratory Wildland Fire Management Environmental Assessment - April 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Irving, J.S.

DOE prepared an environmental assessment (EA)for wildland fire management activities on the Idaho National Engineering and Environmental Laboratory (INEEL) (DOE/EA-1372). The EA was developed to evaluate wildland fire management options for pre-fire, fire suppression, and post fire activities. Those activities have an important role in minimizing the conversion of the native sagebrush steppe ecosystem found on the INEEL to non-native weeds. Four alternative management approaches were analyzed: Alternative 1 - maximum fire protection; Alternative 2 - balanced fire protection; Alternative 2 - balanced fire protection; Alternative 3 - protect infrastructure and personnel; and Alternative 4 - no action/traditional fire protection.

Idaho National Engineering and Environmental Laboratory Wildland Fire Management Environmental Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Irving, John S

DOE prepared an environmental assessment (EA)for wildland fire management activities on the Idaho National Engineering and Environmental Laboratory (INEEL) (DOE/EA-1372). The EA was developed to evaluate wildland fire management options for pre-fire, fire suppression, and post fire activities. Those activities have an important role in minimizing the conversion of the native sagebrush steppe ecosystem found on the INEEL to non-native weeds. Four alternative management approaches were analyzed: Alternative 1 - maximum fire protection; Alternative 2 - balanced fire protection; Alternative 2 - balanced fire protection; Alternative 3 - protect infrastructure and personnel; and Alternative 4 - no action/traditional fire protection.

The Legacy of Early Experiences in Development: Formalizing Alternative Models of How Early Experiences Are Carried Forward over Time

ERIC Educational Resources Information Center

Fraley, R. Chris; Roisman, Glenn I.; Haltigan, John D.

2013-01-01

Psychologists have long debated the role of early experience in social and cognitive development. However, traditional approaches to studying this issue are not well positioned to address this debate. The authors present simulations that indicate that the associations between early experiences and later outcomes should approach different…

Overhauling Technical Handouts for Active Student Participation: A Model for Improving Lecture Efficiency and Increasing Attendance

ERIC Educational Resources Information Center

Jakee, Keith

2011-01-01

This instructional paper is intended to provide an alternative approach to developing lecture materials, including handouts and PowerPoint slides, successfully developed over several years. The principal objective is to aid in the bridging of traditional "chalk and talk" lecture approaches with more active learning techniques, especially in more…

Using Student-Centered Cases in the Classroom: An Action Inquiry Approach to Leadership Development

ERIC Educational Resources Information Center

Foster, Pacey; Carboni, Inga

2009-01-01

This article addresses the concern that business schools are not adequately developing the practical leadership skills that are required in the real world of management. The article begins by discussing the limitations of traditional case methods for teaching behavioral skills. This approach is contrasted with an alternative case method drawn from…

Complementary and alternative approaches used by parents of children with epilepsy on epilepsy management.

PubMed

Işler, Ayşegül; Turan, Fatma Dilek; Gözüm, Sebahat; Oncel, Selma

2014-03-01

The aim of this study was to determine the complementary and alternative approaches used by parents of children with epilepsy on epilepsy management. This descriptive study included a total of 304 parents of children with epilepsy aged between 0 and 18years evaluated at the Pediatric Neurology Clinic of Akdeniz University Hospital in Turkey between January and May 2013. Data were collected by using a questionnaire developed by the researchers. It was determined that all the parents use complementary and alternative approaches for their children with epilepsy, and the most common approaches are praying (99.3%); keeping their children away from the effects of smoking (79.8%); feeding their children walnuts (79.6%), butter (59.2%), and bone marrow (58.6%); providing their children with good quality sleep (58.6%); and enabling their children to play games (51%). The approaches commonly applied during seizures include praying (96.2%), comforting their children in their arms and showing affection (55.6%), waiting for seizures to finish at home (45.7%), and laying children on their side (41.1%). Of parents, 98% stated that alternative approaches enable them to control their child's seizures, 100% said that alternative approaches have no adverse effect, and 98.4% stated that they will continue to use these approaches. The children's approaches to cope with epilepsy included looking after pets (72.7%), listening to music (70.1%), watching television (64.5%), playing games (55.3%), praying (51%), and spending time with friends (48.7%). Most of the approaches used by parents and children with epilepsy for the management of illness are determined to consist of complementary approaches that may contribute to management of epilepsy. Knowing the approaches of parents and children with epilepsy that could adversely affect disease management is important for educating parents and children to avoid these potentially harmful interventions. Copyright © 2013 Elsevier Inc. All rights reserved.

Development of a Compound Optimization Approach Based on Imperialist Competitive Algorithm

NASA Astrophysics Data System (ADS)

Wang, Qimei; Yang, Zhihong; Wang, Yong

In this paper, an improved novel approach is developed for the imperialist competitive algorithm to achieve a greater performance. The Nelder-Meand simplex method is applied to execute alternately with the original procedures of the algorithm. The approach is tested on twelve widely-used benchmark functions and is also compared with other relative studies. It is shown that the proposed approach has a faster convergence rate, better search ability, and higher stability than the original algorithm and other relative methods.

From leader to leadership: clinician managers and where to next?

PubMed

Fulop, Liz; Day, Gary E

2010-08-01

Individual clinician leadership is at the forefront of health reforms in Australia as well as overseas with many programs run by health departments (and hospitals) generally focus on the development of individual leaders. This paper argues, along with others, that leadership in the clinician management context cannot be understood from an individualistic approach alone. Clinician managers, especially in the ranks of doctors, are usually described as 'hybrid-professional managers' as well as reluctant leaders for whom most leadership theories do not easily apply. Their experiences of leadership development programs run by health departments both in Australia and internationally are likely to be based on an individual leader-focussed approach that is driving health care reforms. These approaches work from three key assumptions: (1) study and fix the person; (2) give them a position or title; and (3) make them responsible for results. Some would argue that the combination of these three approaches equates to heroic and transformational leadership. Several alternative approaches to leadership development are presented to illustrate how reforms in healthcare, and notably in hospitals, must incorporate alternative approaches, such as those based on collective and relational forms of leadership. This does not mean eschewing individual approaches to leadership but rather, thinking of them differently and making them more relevant to the daily experiences of clinician managers. We conclude by highlighting several significant challenges facing leadership development for clinician managers that arise from these considerations.

Establishment of subgrade undercut criteria and performance of alternative stabilization measures.

DOT National Transportation Integrated Search

2010-08-25

The main objectives of the research work were to develop a systematic approach for determining whether or not undercut is : necessary, and to investigate the adequacy of stabilization measures as implemented in conjunction with the undercut approach....

Methods of Securing Alternative Funding for Community Colleges. ERIC Digest.

ERIC Educational Resources Information Center

ERIC Clearinghouse for Junior Colleges, Los Angeles, CA.

Now that the growth period for community colleges is over, and public funding has stabilized or decreased, many colleges are turning to alternative funding sources as a means of financing new projects and maintaining services. Among the funding approaches are the following: (1) grants development, which requires a library of material on funding…

Developing Educational Alternatives: Some New Ways for Education in Rural Areas.

ERIC Educational Resources Information Center

Wood, A. W.

The evolution and diversification of alternative educational programmes for rural communities are traced from the "shock-absorber" approach, aimed at a sector of society which presented a visible need, toward community education and some of the working principles behind it. The starting point for examining educational evolution is traditional…

An Alternative Classification Scheme for Teaching Performance Incentives Using a Factor Analytic Approach.

ERIC Educational Resources Information Center

Mertler, Craig A.

This study attempted to (1) expand the dichotomous classification scheme typically used by educators and researchers to describe teaching incentives and (2) offer administrators and teachers an alternative framework within which to develop incentive systems. Elementary, middle, and high school teachers in Ohio rated 10 commonly instituted teaching…

Single-Case Research Design: An Alternative Strategy for Evidence-Based Practice

ERIC Educational Resources Information Center

Stapleton, Drue; Hawkins, Andrew

2015-01-01

Objective: The trend of utilizing evidence-based practice (EBP) in athletic training is now requiring clinicians, researchers, educators, and students to be equipped to both engage in and make judgments about research evidence. Single-case design (SCD) research may provide an alternative approach to develop such skills and inform clinical and…

ALTERNATIVE APPROACH TO ESTIMATING CANCER ...

EPA Pesticide Factsheets

The alternative approach for estimating cancer potency from inhalation exposure to asbestos seeks to improve the methods developed by USEPA (1986). This efforts seeks to modify the the current approach for estimating cancer potency for lung cancer and mesothelioma to account for the current scientific consensus that cancer risk from asbestos depends both on mineral type and on particle size distribution. In brief, epidemiological exposure-response data for lung cancer and mesothelioma in asbestos workers are combined with estimates of the mineral type(s) and partical size distribution at each exposure location in order to estimate potency factors that are specific to a selected set of mineral type and size

75 FR 41173 - Call for Information: Information on Greenhouse Gas Emissions Associated With Bioenergy and Other...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

... oversimplify a complex issue. If this is the case, what alternative approaches or additional analytical tools... Information to solicit information and viewpoints from interested parties on approaches to accounting for... comment on developing an approach for such emissions under the Prevention of Significant Deterioration...

Teaching Mathematical Induction: An Alternative Approach.

ERIC Educational Resources Information Center

Allen, Lucas G.

2001-01-01

Describes experience using a new approach to teaching induction that was developed by the Mathematical Methods in High School Project. The basic idea behind the new approach is to use induction to prove that two formulas, one in recursive form and the other in a closed or explicit form, will always agree for whole numbers. (KHR)

Using population viability criteria to assess strategies to minimize disease threats for an endangered carnivore.

PubMed

Doak, Daniel F; Bakker, Victoria J; Vickers, Winston

2013-04-01

Outbreaks of infectious disease represent serious threats to the viability of many vertebrate populations, but few studies have included quantitative evaluations of alternative approaches to the management of disease. The most prevalent management approach is monitoring for and rapid response to an epizootic. An alternative is vaccination of a subset of the free-living population (i.e., a "vaccinated core") such that some individuals are partially or fully immune in the event of an epizootic. We developed a simulation model describing epizootic dynamics, which we then embedded in a demographic simulation to assess these alternative approaches to managing rabies epizootics in the island fox (Urocyon littoralis), a species composed of only 6 small populations on the California Channel Islands. Although the monitor and respond approach was superior to the vaccinated-core approach for some transmission models and parameter values, this type of reactive management did not protect the population from rabies under many disease-transmission assumptions. In contrast, a logistically feasible program of prophylactic vaccination for part of the wild population yielded low extinction probabilities across all likely disease-transmission scenarios, even with recurrent disease introductions. Our use of a single metric of successful management-probability of extreme endangerment (i.e., quasi extinction)-to compare very different management approaches allowed an objective assessment of alternative strategies for controlling the threats posed by infectious disease outbreaks. © 2013 Society for Conservation Biology.

Short-Term Intercultural Psychotherapy: Ethnographic Inquiry

ERIC Educational Resources Information Center

Seeley, Karen M.

2004-01-01

This article examines the challenges specific to short-term intercultural treatments and recently developed approaches to intercultural treatments based on notions of cultural knowledge and cultural competence. The article introduces alternative approaches to short-term intercultural treatments based on ethnographic inquiry adapted for clinical…

Cross-Sectional Time Series Designs: A General Transformation Approach.

ERIC Educational Resources Information Center

Velicer, Wayne F.; McDonald, Roderick P.

1991-01-01

The general transformation approach to time series analysis is extended to the analysis of multiple unit data by the development of a patterned transformation matrix. The procedure includes alternatives for special cases and requires only minor revisions in existing computer software. (SLD)

The Application of a Multiphase Triangulation Approach to Mixed Methods: The Research of an Aspiring School Principal Development Program

ERIC Educational Resources Information Center

Youngs, Howard; Piggot-Irvine, Eileen

2012-01-01

Mixed methods research has emerged as a credible alternative to unitary research approaches. The authors show how a combination of a triangulation convergence model with a triangulation multilevel model was used to research an aspiring school principal development pilot program. The multilevel model is used to show the national and regional levels…

Analysis of the proposed EU regulation concerning biocide products and its opportunities for alternative approaches and a toxicology for the 21st century (t4 report).

PubMed

Ferrario, Daniele; Rabbit, Richard R

2012-01-01

On June 12, 2009, the European Commission adopted a proposal for a Regulation concerning the placement on the market and use of biocidal products, which, when it enters into force on January 1, 2013, will repeal and replace Directive 98/8/EC. The main reason for the revision of the current Directive was to promote best practices for environmental and human health protection, along with implementation of current developments in safety testing in order to create safer biocides. Moreover, the proposed Regulation aims to take into consideration the newest legislation on chemicals. This article evaluates the proposed Regulation in comparison to Directive 98/8/EC. Although the new proposal requires the sharing of vertebrate animal test data, both for product authorization and for newly developed active substances, it misses - in contrast to REACH - the opportunity to recognize the accelerating development of alternative approaches to animal testing, most recently with new momentum provided by "Toxicity Testing for the 21st Century", and to support the evolution of toxicology towards a new approach to testing. The new methods promise not only to decrease animal pain and suffering, but also to provide faster results and better prediction for human risk assessment compared to traditional methods. Unfortunately, methods mandated for human risk assessment in the proposal are still mainly based on traditional animal study extrapolation. We put forward and discuss possible alternative strategies, such as in vitro testing, integrated testing strategies, toxicokinetics, "omics", systems biology, bioinformatics, and computational modeling, all of which could be more encouraged by the proposal. Current opportunities to improve our tools for biocide risk assessment are discussed, delineating advantages, limitations, and development needs. It is suggested to open the proposed Regulation to alternative approaches that are based on human biology more than on extrapolation from animals to humans.

Active Engagement Strategies for Introductory Physics

NASA Astrophysics Data System (ADS)

Kolitch, Shawn

2001-05-01

Evidence suggests that traditional lectures result in only minimal gains in student understanding of fundamental concepts in introductory physics. However, alternative approaches developed by physics education researchers seem to be more effective. In this talk I will review some of the evidence for these claims, discuss several possible alternatives to the traditional model of instruction, and describe some of the logistics involved in the implementation of such alternatives at both a large public university and a small liberal arts college.

A review of alternatives to di (2-ethylhexyl) phthalate-containing medical devices in the neonatal intensive care unit

PubMed Central

Van Vliet, EDS; Reitano, EM; Chhabra, JS; Bergen, GP; Whyatt, RM

2012-01-01

Objective To conduct an extensive literature and toxicological database review on substitute compounds and available alternative medical products to replace polyvinyl chloride (PVC) and/or di(2-ethylhexyl) phthalate (DEHP), and conduct a DEHP-medical inventory analysis at a large metropolitan neonatal intensive care unit (NICU). Study Design A systematic search for DEHP-free alternative products was performed using online databases. An informal audit of a large metropolitan NICU was undertaken in 2005 and 2006; 21 products were identified that could potentially contain DEHP. Availability of DEHP-free alternatives was determined through company websites and phone interviews. Result Two alternative approaches are available for replacing DEHP in NICU medical products: (1) replacement by DEHP-free plasticizers; and (2) replacement of PVC entirely through the use of other polymers. Both approaches seem to provide less harmful substitutes to DEHP, but support PVC-free polymers as the preferred alternative. However, significant data gaps exist, particularly for the alternative polymers. In all, 10 out of 21 (48%) products in the NICU audit were DEHP-free; six consisted of alternative polymers and four of alternative plasticizers. Of the remaining 11 products, only three were available without DEHP at the time of the audit. Conclusion Because of significant data gaps, systematic toxicological testing of DEHP-free alternatives is imperative. Continued development of alternative products is also needed. PMID:21311501

SMARTE: IMPROVING REVITALIZATION DECISIONS - PRESENTATION IN NRMRL SEMINAR SERIES

EPA Science Inventory

SMARTe (Sustainable Management Approaches and Revitalization Tools-electribuc) is an open-source, web-based, decision-support system for developing and evaluating alternative reuse scenarios for potentially contaminated sites (e.g., brownfields). It is being developed collaborati...

SMARTE: IMPROVING REVITALIZATION DECISIONS - PRESENTATION FOR ETV INTERNATIONAL FORUM

EPA Science Inventory

SMARTe (Sustainable Management Approaches and Revitalization Tools - electronic) is an open-source, web-based, decision-support system for developing and evaluating alternative reuse scenarios for potentially contaminated sites (e.g., brownfields). It is being developed collabora...

Thinking Egyptian: Active Models for Understanding Spatial Representation.

ERIC Educational Resources Information Center

Schiferl, Ellen

This paper highlights how introductory textbooks on Egyptian art inhibit understanding by reinforcing student preconceptions, and demonstrates another approach to discussing space with a classroom exercise and software. The alternative approach, an active model for spatial representation, introduced here was developed by adapting classroom…

Evaluating cardiac risk: exposure response analysis in early clinical drug development.

PubMed

Grenier, Julie; Paglialunga, Sabina; Morimoto, Bruce H; Lester, Robert M

2018-01-01

The assessment of a drug's cardiac liability has undergone considerable metamorphosis by regulators since International Council for Harmonization of Technical Requirement for Pharmaceuticals for Human Use E14 guideline was introduced in 2005. Drug developers now have a choice in how proarrhythmia risk can be evaluated; the options include a dedicated thorough QT (TQT) study or exposure response (ER) modeling of intensive electrocardiogram (ECG) captured in early clinical development. The alternative approach of ER modeling was incorporated into a guidance document in 2015 as a primary analysis tool which could be utilized in early phase dose escalation studies as an option to perform a dedicated TQT trial. This review will describe the current state of ER modeling of intensive ECG data collected during early clinical drug development; the requirements with regard to the use of a positive control; and address the challenges and opportunities of this alternative approach to assessing QT liability.

Economic development: the need for an alternative approach. [Case of Libya

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pinches, C.R.

1977-10-01

The economic growth of Libya is used to illustrate the need for a more relevant way of assessing development so that it includes an appreciation for the process of change. It is shown that many changes do not appear in the traditional economic statistics. A new approach is suggested that would enable a society to handle changes in ways that are in accord with its national goals and traditions. This would take into account future developments, international relations, the basic skill levels, and other factors rather than a limited measurement of the country's ability to absorb capital. Libya has chosen,more » as an alternative to increased consumption, policies for developing self-sufficiency, a limited foreign investment, and an emphasis on education as a basis for modernization. The goal is to evolve a national identity and ideology that will be unique to the Arab world. (DCK)« less

Alienation and Engagement: Development of an Alternative Theoretical Framework for Understanding Student Learning

ERIC Educational Resources Information Center

Case, Jennifer M.

2008-01-01

In this paper it is suggested that the themes of alienation and engagement offer a productive alternative perspective for characterising the student experience of learning in higher education, compared to current dominant perspectives such as that offered by approaches to learning and related concepts. A conceptual and historical background of the…

An Alternative to the Use of Animals to Teach Diabetes Mellitus

ERIC Educational Resources Information Center

Basso, Paulo José; Tazinafo, Lucas Favaretto; Silva, Mauro Ferreira; Rocha, Maria José Alves

2014-01-01

We developed an alternative approach to teach diabetes mellitus in our practical classes, replacing laboratory animals. We used custom rats made of cloth, which have a ventral zipper that allows stuffing with glass marbles to reach different weights. Three mock rats per group were placed into metabolic cages with real food and water and with test…

Variables Influencing the Return on Investment in Management Training Programs: A Utility Analysis of 10 Swiss Cases

ERIC Educational Resources Information Center

Chochard, Yves; Davoine, Eric

2011-01-01

In this article, we present the utility analysis approach as an alternative and promising approach to measure the return on investment in managerial training programs. This approach, linking economic value with competencies developed by trainees, enables researchers and decision-makers to compare the return on investment from different programs in…

Finding "Meaning" in Psychology: A Lay Theories Approach to Self-Regulation, Social Perception, and Social Development

ERIC Educational Resources Information Center

Molden, Daniel C.; Dweck, Carol S.

2006-01-01

Much of psychology focuses on universal principles of thought and action. Although an extremely productive pursuit, this approach, by describing only the "average person," risks describing no one in particular. This article discusses an alternate approach that complements interests in universal principles with analyses of the unique psychological…

Communities of Practice: A Research Paradigm for the Mixed Methods Approach

ERIC Educational Resources Information Center

Denscombe, Martyn

2008-01-01

The mixed methods approach has emerged as a "third paradigm" for social research. It has developed a platform of ideas and practices that are credible and distinctive and that mark the approach out as a viable alternative to quantitative and qualitative paradigms. However, there are also a number of variations and inconsistencies within the mixed…

The International Development of the "Social Norms" Approach to Drug Education and Prevention

ERIC Educational Resources Information Center

McAlaney, John; Bewick, Bridgette; Hughes, Clarissa

2011-01-01

The social norms approach to health promotion has become remarkably popular in the last 20 years, particularly in the American college system. It is an alternative to traditional fear-based approaches of health education, which a growing body of research demonstrates is often ineffective in reducing alcohol and drug misuse. The social norms…

An evaluation of alternative cleaning methods for removing an organic contaminant from a stainless steel part

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, J.L.

1996-08-01

As of December 1995, the manufacture of Freon, along with many other chlorofluorocarbons (CFCs), was prohibited by the Clean Air Act of 1990 (CAA). The ban of CFC solvents has forced manufacturers across the country to search for alternative metal cleaning techniques. The objective of this study was to develop a thorough, scientific based approach for resolving one specific manufacturer`s problem of removing organic contamination from a stainless steel part. This objective was accomplished with an approach that involved: (1) defining the problem, (2) identifying the process constraints, (3) researching alternate cleaning methods, (4) researching applicable government regulations, (5) performingmore » a scientific evaluation and (6) drawing conclusions.« less

Endoscopic and minimally invasive microsurgical approaches for treating brain tumor patients.

PubMed

Badie, Behnam; Brooks, Nathaniel; Souweidane, Mark M

2004-01-01

Recent developments in neuroendoscopy and minimally invasive procedures have greatly impacted the diagnosis and treatment of brain tumors. In this paper, we will review these innovations and discuss how they have influenced our approach to the treatment of intraventricular and pituitary tumors. Finally, the concept of keyhole neurosurgery is illustrated by discussing 'eyebrow orbitotomy' approach as an example. As noninvasive therapeutic alternative become available, future neurosurgeons will be challenged to develop effective and less invasive surgical approaches for the diagnosis and treatment of patients will brain tumors.

Predicting the carcinogenicity of chemicals with alternative approaches: recent advances.

PubMed

Benigni, Romualdo

2014-09-01

Alternative approaches to the rodent bioassay are necessary for early identification of problematic drugs and biocides during the development process, and are the only practicable tool for assessing environmental chemicals with no or adequate safety documentation. This review informs on: i) the traditional prescreening through genotoxicity testing; ii) an integrative approach that assesses DNA-reactivity and ability to disorganize tissues; iii) new applications of omics technologies (ToxCast/Tox21 project); iv) a pragmatic approach aimed at filling data gaps by intrapolating/extrapolating from similar chemicals (read-across, category formation). The review also approaches the issue of the concerns about false-positive and false-negative results that prevents a wider acceptance and use of alternatives. The review addresses strengths and limitations of various proposals, and concludes on the need of differential approaches to the issue of false negatives and false positives. False negatives can be eliminated or reduced below the variability of the animal assay with conservative quantitative structure-activity relationships or in vitro tests; false positives can be cleared with ad hoc mechanistically based follow-ups. This framework can permit a reduction of animal testing and a better protection of human health.

Description of the Prometheus Program Alternator/Thruster Integration Laboratory (ATIL)

NASA Technical Reports Server (NTRS)

Baez, Anastacio N.; Birchenough, Arthur G.; Lebron-Velilla, Ramon C.; Gonzalez, Marcelo C.

2005-01-01

The Project Prometheus Alternator Electric Thruster Integration Laboratory's (ATIL) primary two objectives are to obtain test data to influence the power conversion and electric propulsion systems design, and to assist in developing the primary power quality specifications prior to system Preliminary Design Review (PDR). ATIL is being developed in stages or configurations of increasing fidelity and complexity in order to support the various phases of the Prometheus program. ATIL provides a timely insight of the electrical interactions between a representative Permanent Magnet Generator, its associated control schemes, realistic electric system loads, and an operating electric propulsion thruster. The ATIL main elements are an electrically driven 100 kWe Alternator Test Unit (ATU), an alternator controller using parasitic loads, and a thruster Power Processing Unit (PPU) breadboard. This paper describes the ATIL components, its development approach, preliminary integration test results, and current status.

The vaccines consistency approach project: an EPAA initiative.

PubMed

De Mattia, F; Hendriksen, C; Buchheit, K H; Chapsal, J M; Halder, M; Lambrigts, D; Redhead, K; Rommel, E; Scharton-Kersten, T; Sesardic, T; Viviani, L; Ragan, I

2015-01-01

The consistency approach for release testing of established vaccines promotes the use of in vitro, analytical, non-animal based systems allowing the monitoring of quality parameters during the whole production process. By using highly sensitive non-animal methods, the consistency approach has the potential to improve the quality of testing and to foster the 3Rs (replacement, refinement and reduction of animal use) for quality control of established vaccines. This concept offers an alternative to the current quality control strategy which often requires large numbers of laboratory animals. In order to facilitate the introduction of the consistency approach for established human and veterinary vaccine quality control, the European Partnership for Alternatives to Animal Testing (EPAA) initiated a project, the "Vaccines Consistency Approach Project", aiming at developing and validating the consistency approach with stakeholders from academia, regulators, OMCLs, EDQM, European Commission and industry. This report summarises progress since the project's inception.

Treating alcoholism as a chronic disease: approaches to long-term continuing care.

PubMed

McKay, James R; Hiller-Sturmhofel, Susanne

2011-01-01

For many patients, alcohol and other drug (AOD) use disorders are chronic, recurring conditions involving multiple cycles of treatment, abstinence, and relapse. To disrupt this cycle, treatment can include continuing care to reduce the risk of relapse. The most commonly used treatment approach is initial intensive inpatient or outpatient care based on 12-step principles, followed by continuing care involving self-help groups, 12-step group counseling, or individual therapy. Although these programs can be effective, many patients drop out of initial treatment or do not complete continuing care. Thus, researchers and clinicians have begun to develop alternative approaches to enhance treatment retention in both initial and continuing care. One focus of these efforts has been the design of extended treatment models. These approaches increasingly blur the distinction between initial and continuing care and aim to prolong treatment participation by providing a continuum of care. Other researchers have focused on developing alternative treatment strategies (e.g., telephone-based interventions) that go beyond traditional settings and adaptive treatment algorithms that may improve outcomes for clients who do not respond well to traditional approaches.

Cell delivery in regenerative medicine: the cell sheet engineering approach.

PubMed

Yang, Joseph; Yamato, Masayuki; Nishida, Kohji; Ohki, Takeshi; Kanzaki, Masato; Sekine, Hidekazu; Shimizu, Tatsuya; Okano, Teruo

2006-11-28

Recently, cell-based therapies have developed as a foundation for regenerative medicine. General approaches for cell delivery have thus far involved the use of direct injection of single cell suspensions into the target tissues. Additionally, tissue engineering with the general paradigm of seeding cells into biodegradable scaffolds has also evolved as a method for the reconstruction of various tissues and organs. With success in clinical trials, regenerative therapies using these approaches have therefore garnered significant interest and attention. As a novel alternative, we have developed cell sheet engineering using temperature-responsive culture dishes, which allows for the non-invasive harvest of cultured cells as intact sheets along with their deposited extracellular matrix. Using this approach, cell sheets can be directly transplanted to host tissues without the use of scaffolding or carrier materials, or used to create in vitro tissue constructs via the layering of individual cell sheets. In addition to simple transplantation, cell sheet engineered constructs have also been applied for alternative therapies such as endoscopic transplantation, combinatorial tissue reconstruction, and polysurgery to overcome limitations of regenerative therapies and cell delivery using conventional approaches.

Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neves, Bruno Miguel; Centro de Neurociencias e Biologia Celular, Universidade de Coimbra, Coimbra 3004-517; Goncalo, Margarida

2011-01-15

The development of non-animal testing methods for the assessment of skin sensitisation potential is an urgent challenge within the framework of existing and forthcoming legislation. Efforts have been made to replace current animal tests, but so far no alternative methods have been developed. It is widely recognised that alternatives to animal testing cannot be accomplished with a single approach, but rather will require the integration of results obtained from different in vitro and in silico assays. The argument subjacent to the development of in vitro dendritic cell (DC)-based assays is that sensitiser-induced changes in the DC phenotype can be differentiatedmore » from those induced by irritants. This assumption is derived from the unique capacity of DC to convert environmental signals encountered at the skin into a receptor expression pattern (MHC class II molecules, co-stimulatory molecules, chemokine receptors) and a soluble mediator release profile that will stimulate T lymphocytes. Since signal transduction cascades precede changes in surface marker expression and cytokine/chemokine secretion, these phenotypic modifications are a consequence of a signal transduction profile that is specifically triggered by sensitisers and not by irritants. A limited number of studies have addressed this subject and the present review attempts to summarise and highlight all of the signalling pathways modulated by skin sensitisers and irritants. Furthermore, we conclude this review by focusing on the most promising strategies suitable for inclusion into a cell-based in vitro alternative approach to hazard identification.« less

Multilevel Modeling of Social Segregation

ERIC Educational Resources Information Center

Leckie, George; Pillinger, Rebecca; Jones, Kelvyn; Goldstein, Harvey

2012-01-01

The traditional approach to measuring segregation is based upon descriptive, non-model-based indices. A recently proposed alternative is multilevel modeling. The authors further develop the argument for a multilevel modeling approach by first describing and expanding upon its notable advantages, which include an ability to model segregation at a…

Cultural pathways through universal development.

PubMed

Greenfield, Patricia M; Keller, Heidi; Fuligni, Andrew; Maynard, Ashley

2003-01-01

We focus our review on three universal tasks of human development: relationship formation, knowledge acquisition, and the balance between autonomy and relatedness at adolescence. We present evidence that each task can be addressed through two deeply different cultural pathways through development: the pathways of independence and interdependence. Whereas core theories in developmental psychology are universalistic in their intentions, they in fact presuppose the independent pathway of development. Because the independent pathway is therefore well-known in psychology, we focus a large part of our review on empirically documenting the alternative, interdependent pathway for each developmental task. We also present three theoretical approaches to culture and development: the ecocultural, the sociohistorical, and the cultural values approach. We argue that an understanding of cultural pathways through human development requires all three approaches. We review evidence linking values (cultural values approach), ecological conditions (ecocultural approach), and socialization practices (sociohistorical approach) to cultural pathways through universal developmental tasks.

Developing Creativity through Collaborative Problem Solving

ERIC Educational Resources Information Center

Albert, Lillie R.; Kim, Rina

2013-01-01

This paper discusses an alternative approach for developing problem solving experiences for students. The major argument is that students can develop their creativity by engaging in collaborative problem solving activities in which they apply a variety of mathematical methods creatively to solve problems. The argument is supported by: considering…

Alternative Test Methods for Developmental Neurotoxicity: A ...

EPA Pesticide Factsheets

Exposure to environmental contaminants is well documented to adversely impact the development of the nervous system. However, the time, animal and resource intensive EPA and OECD testing guideline methods for developmental neurotoxicity (DNT) are not a viable solution to characterizing potential chemical hazards for the thousands of untested chemicals currently in commerce. Thus, research efforts over the past decade have endeavored to develop cost-effective alternative DNT testing methods. These efforts have begun to generate data that can inform regulatory decisions. Yet there are major challenges to both the acceptance and use of this data. Major scientific challenges for DNT include development of new methods and models that are “fit for purpose”, development of a decision-use framework, and regulatory acceptance of the methods. It is critical to understand that use of data from these methods will be driven mainly by the regulatory problems being addressed. Some problems may be addressed with limited datasets, while others may require data for large numbers of chemicals, or require the development and use of new biological and computational models. For example mechanistic information derived from in vitro DNT assays can be used to inform weight of evidence (WoE) or integrated approaches to testing and assessment (IATA) approaches for chemical-specific assessments. Alternatively, in vitro data can be used to prioritize (for further testing) the thousands

Advances in adaptive control theory: Gradient- and derivative-free approaches

NASA Astrophysics Data System (ADS)

Yucelen, Tansel

In this dissertation, we present new approaches to improve standard designs in adaptive control theory, and novel adaptive control architectures. We first present a novel Kalman filter based approach for approximately enforcing a linear constraint in standard adaptive control design. One application is that this leads to alternative forms for well known modification terms such as e-modification. In addition, it leads to smaller tracking errors without incurring significant oscillations in the system response and without requiring high modification gain. We derive alternative forms of e- and adaptive loop recovery (ALR-) modifications. Next, we show how to use Kalman filter optimization to derive a novel adaptation law. This results in an optimization-based time-varying adaptation gain that reduces the need for adaptation gain tuning. A second major contribution of this dissertation is the development of a novel derivative-free, delayed weight update law for adaptive control. The assumption of constant unknown ideal weights is relaxed to the existence of time-varying weights, such that fast and possibly discontinuous variation in weights are allowed. This approach is particulary advantageous for applications to systems that can undergo a sudden change in dynamics, such as might be due to reconfiguration, deployment of a payload, docking, or structural damage, and for rejection of external disturbance processes. As a third and final contribution, we develop a novel approach for extending all the methods developed in this dissertation to the case of output feedback. The approach is developed only for the case of derivative-free adaptive control, and the extension of the other approaches developed previously for the state feedback case to output feedback is left as a future research topic. The proposed approaches of this dissertation are illustrated in both simulation and flight test.

Advancing Alternative Analysis: Integration of Decision Science.

PubMed

Malloy, Timothy F; Zaunbrecher, Virginia M; Batteate, Christina M; Blake, Ann; Carroll, William F; Corbett, Charles J; Hansen, Steffen Foss; Lempert, Robert J; Linkov, Igor; McFadden, Roger; Moran, Kelly D; Olivetti, Elsa; Ostrom, Nancy K; Romero, Michelle; Schoenung, Julie M; Seager, Thomas P; Sinsheimer, Peter; Thayer, Kristina A

2017-06-13

Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals. We assessed whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics. A workshop was convened that included representatives from government, academia, business, and civil society and included experts in toxicology, decision science, alternatives assessment, engineering, and law and policy. Participants were divided into two groups and were prompted with targeted questions. Throughout the workshop, the groups periodically came together in plenary sessions to reflect on other groups' findings. We concluded that the further incorporation of decision science into alternatives analysis would advance the ability of companies and regulators to select alternatives to harmful ingredients and would also advance the science of decision analysis. We advance four recommendations: a ) engaging the systematic development and evaluation of decision approaches and tools; b ) using case studies to advance the integration of decision analysis into alternatives analysis; c ) supporting transdisciplinary research; and d ) supporting education and outreach efforts. https://doi.org/10.1289/EHP483.

Advancing Alternative Analysis: Integration of Decision Science

PubMed Central

Zaunbrecher, Virginia M.; Batteate, Christina M.; Blake, Ann; Carroll, William F.; Corbett, Charles J.; Hansen, Steffen Foss; Lempert, Robert J.; Linkov, Igor; McFadden, Roger; Moran, Kelly D.; Olivetti, Elsa; Ostrom, Nancy K.; Romero, Michelle; Schoenung, Julie M.; Seager, Thomas P.; Sinsheimer, Peter; Thayer, Kristina A.

2017-01-01

Background: Decision analysis—a systematic approach to solving complex problems—offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals. Objectives: We assessed whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics. Methods: A workshop was convened that included representatives from government, academia, business, and civil society and included experts in toxicology, decision science, alternatives assessment, engineering, and law and policy. Participants were divided into two groups and were prompted with targeted questions. Throughout the workshop, the groups periodically came together in plenary sessions to reflect on other groups’ findings. Results: We concluded that the further incorporation of decision science into alternatives analysis would advance the ability of companies and regulators to select alternatives to harmful ingredients and would also advance the science of decision analysis. Conclusions: We advance four recommendations: a) engaging the systematic development and evaluation of decision approaches and tools; b) using case studies to advance the integration of decision analysis into alternatives analysis; c) supporting transdisciplinary research; and d) supporting education and outreach efforts. https://doi.org/10.1289/EHP483 PMID:28669940

An Ecological Approach to Seeking and Utilising the Views of Young People with Intellectual Disabilities in Transition Planning

ERIC Educational Resources Information Center

Small, Neil; Raghavan, Raghu; Pawson, Nicole

2013-01-01

Transition planning using a person-centred approach has, in the main, failed to shape service provision. We offer an alternative based on an ecological understanding of human development linked to public health approaches that prioritise whole system planning. A total of 43 young people with intellectual disabilities, in Bradford, England, who…

A Social Justice Alternative for Framing Post-Compulsory Education: A Human Development Perspective of VET in Times of Economic Dominance

ERIC Educational Resources Information Center

Lopez-Fogues, Aurora

2016-01-01

The article provides an alternative theoretical framework for evaluating contemporary issues facing education, specifically vocational education and training (VET) in Europe. In order to accomplish this, it draws on the theoretical insights of the capability approach in the work of Amartya Sen; the concept of vulnerability as intrinsic to every…

The VTAC Committee: developing guidance for an alternative regulatory pathway to the anadromous salmonid protection rules

Treesearch

Michael Liquori; Peter Cafferata; Kevin Boston; Richard Gienger; David Hope

2012-01-01

In recent decades, riparian protection standards have been guided by generalized prescriptive rules. With the passage of the Anadromous Salmonid Protection rules in 2009, the Board of Forestry and Fire Protection (Board) established a regulatory pathway that provides an alternative approach for riparian protection based on site-specific criteria (14 CCR § 916....

AN ALTERNATIVE METHOD FOR ESTABLISHING TEFS FOR DIXON-LIKE COMPOUNDS. PART 2. DEVELOPMENT OF AN APPROACH TO QUANTITATIVELY WEIGHT THE UNDERLYING POTENCY DATA

EPA Science Inventory

The current approach for evaluating potential health risks associated with exposure to mixtures of polychlorinated dibenzo-p-dixoins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs) [hereafter referred to as "dioxin-like compoun...

All the World's a Stage: Transforming Entrepreneurship Education through Design Thinking

ERIC Educational Resources Information Center

Huq, Afreen; Gilbert, David

2017-01-01

Purpose: The purpose of this paper is to present an alternate approach to entrepreneurship pedagogy development through an iterative journey of co-ownership between students, industry partners and academic course teams to enhance student satisfaction and learning outcomes. Design/methodology/approach: Utilising design thinking, the pedagogy…

System identification principles in studies of forest dynamics.

Treesearch

Rolfe A. Leary

1970-01-01

Shows how it is possible to obtain governing equation parameter estimates on the basis of observed system states. The approach used represents a constructive alternative to regression techniques for models expressed as differential equations. This approach allows scientists to more completely quantify knowledge of forest development processes, to express theories in...

Appreciative Inquiry and Student Affairs: A Positive Approach to Change

ERIC Educational Resources Information Center

Lehner, Rachelle; Hight, Donna L.

2006-01-01

Appreciative Inquiry (AI) is an organization development (OD) philosophy that utilizes and builds on past successes, using these as positive momentum for future change. AI provides student affairs with an alternative and generative approach to improving their organizations' processes and culture. As student affairs professionals look to the future…

Alternatives--One Approach to Drug Education.

ERIC Educational Resources Information Center

Dohner, V. Alton

This publication attempts to produce greater understanding of the complex problems of drug abuse and drug dependence. The major emphasis for prevention is through helping children develop to a healthy maturity. Section One discusses various approaches to drug education (scare and fear, matter-of-fact, styles of use and motives, society and…

Alternative approaches for the control of gastrointestinal nematodes in sheep farming: a review.

PubMed

Šimpraga, Miljenko; Ljubičić, Iva; Hlede, Jadranka Pejaković; Vugrovečki, Ana Shek; Marinculić, Albert; Tkalčić, Suzana

2015-01-01

Gastrointestinal nematodes (GIN) are a serious health problem and represent the most significant constraint in sheep grazing operations. Problems tend to be worse in organic sheep farming systems, as a consequence of a less restricted access of animals to outdoor environment with a higher exposure to infective larvae. In domestic animals, GIN are effectively controlled by an aggressive prophylactic administration of commercially available anthelmintics. As a consequence to a common overdose and misuse of readily available antiparasitic treatments, there is an inevitable development of populations of GIN resistant to all major classes of anthelmintics. Also, the control of GIN that is based entirely on the anthelmintic use, threatens sustainability of the sheep farming worldwide. The combination of the optimized use of anthelmintic drugs and alternative approaches seem to be a reasonable choice in sustainable parasitic control programs that offer a substantial reduction of anthelmintic treatments and conservation of anthelmintic efficacy. In that aspect, a "targeted selective treatment (TST)" directed towards animals clinically diagnosed with GIN, seems to be an effective approach to leave some parasite populations unexposed to anthelmintics (refugia) and to reduce development of anthelmintic resistance. Also, many current research efforts aim to find and validate sustainable non-chemotherapeutic approaches to GIN control, including changes in grazing management, optimized nutrition, dietary supplementation, consumption of plants with anthelmintic properties, biological control by nematophagous fungi, copper oxide wire particles (COWP), and homeopathic treatments. This manuscript outlines (outlines) and discusses relevant alternative approaches for GIN control in modern sheep farming systems.

Educational Diagnostic Assessment.

ERIC Educational Resources Information Center

Bejar, Isaac I.

1984-01-01

Approaches proposed for educational diagnostic assessment are reviewed and identified as deficit assessment and error analysis. The development of diagnostic instruments may require a reexamination of existing psychometric models and development of alternative ones. The psychometric and content demands of diagnostic assessment all but require test…

International Harmonization and Cooperation in the Validation of Alternative Methods.

PubMed

Barroso, João; Ahn, Il Young; Caldeira, Cristiane; Carmichael, Paul L; Casey, Warren; Coecke, Sandra; Curren, Rodger; Desprez, Bertrand; Eskes, Chantra; Griesinger, Claudius; Guo, Jiabin; Hill, Erin; Roi, Annett Janusch; Kojima, Hajime; Li, Jin; Lim, Chae Hyung; Moura, Wlamir; Nishikawa, Akiyoshi; Park, HyeKyung; Peng, Shuangqing; Presgrave, Octavio; Singer, Tim; Sohn, Soo Jung; Westmoreland, Carl; Whelan, Maurice; Yang, Xingfen; Yang, Ying; Zuang, Valérie

The development and validation of scientific alternatives to animal testing is important not only from an ethical perspective (implementation of 3Rs), but also to improve safety assessment decision making with the use of mechanistic information of higher relevance to humans. To be effective in these efforts, it is however imperative that validation centres, industry, regulatory bodies, academia and other interested parties ensure a strong international cooperation, cross-sector collaboration and intense communication in the design, execution, and peer review of validation studies. Such an approach is critical to achieve harmonized and more transparent approaches to method validation, peer-review and recommendation, which will ultimately expedite the international acceptance of valid alternative methods or strategies by regulatory authorities and their implementation and use by stakeholders. It also allows achieving greater efficiency and effectiveness by avoiding duplication of effort and leveraging limited resources. In view of achieving these goals, the International Cooperation on Alternative Test Methods (ICATM) was established in 2009 by validation centres from Europe, USA, Canada and Japan. ICATM was later joined by Korea in 2011 and currently also counts with Brazil and China as observers. This chapter describes the existing differences across world regions and major efforts carried out for achieving consistent international cooperation and harmonization in the validation and adoption of alternative approaches to animal testing.

A Comparison of Alternative Distributed Dynamic Cluster Formation Techniques for Industrial Wireless Sensor Networks.

PubMed

Gholami, Mohammad; Brennan, Robert W

2016-01-06

In this paper, we investigate alternative distributed clustering techniques for wireless sensor node tracking in an industrial environment. The research builds on extant work on wireless sensor node clustering by reporting on: (1) the development of a novel distributed management approach for tracking mobile nodes in an industrial wireless sensor network; and (2) an objective comparison of alternative cluster management approaches for wireless sensor networks. To perform this comparison, we focus on two main clustering approaches proposed in the literature: pre-defined clusters and ad hoc clusters. These approaches are compared in the context of their reconfigurability: more specifically, we investigate the trade-off between the cost and the effectiveness of competing strategies aimed at adapting to changes in the sensing environment. To support this work, we introduce three new metrics: a cost/efficiency measure, a performance measure, and a resource consumption measure. The results of our experiments show that ad hoc clusters adapt more readily to changes in the sensing environment, but this higher level of adaptability is at the cost of overall efficiency.

A Comparison of Alternative Distributed Dynamic Cluster Formation Techniques for Industrial Wireless Sensor Networks

PubMed Central

Gholami, Mohammad; Brennan, Robert W.

2016-01-01

In this paper, we investigate alternative distributed clustering techniques for wireless sensor node tracking in an industrial environment. The research builds on extant work on wireless sensor node clustering by reporting on: (1) the development of a novel distributed management approach for tracking mobile nodes in an industrial wireless sensor network; and (2) an objective comparison of alternative cluster management approaches for wireless sensor networks. To perform this comparison, we focus on two main clustering approaches proposed in the literature: pre-defined clusters and ad hoc clusters. These approaches are compared in the context of their reconfigurability: more specifically, we investigate the trade-off between the cost and the effectiveness of competing strategies aimed at adapting to changes in the sensing environment. To support this work, we introduce three new metrics: a cost/efficiency measure, a performance measure, and a resource consumption measure. The results of our experiments show that ad hoc clusters adapt more readily to changes in the sensing environment, but this higher level of adaptability is at the cost of overall efficiency. PMID:26751447

The Citizen/Teacher Curriculum Council: A Curriculum Development Involvement Strategy.

ERIC Educational Resources Information Center

Peters, Richard O.

In most school systems today, curriculum development is the work of specialists who function as consultants to classroom teachers, administrators, and school boards. An alternative is the Citizen/Teacher Curriculum Council (C/TCC) approach, which calls for direct involvement of community members and classroom teachers in curriculum development.…

New developments in bait stations for control of pest Tephritids

USDA-ARS?s Scientific Manuscript database

Bait stations are being developed and tested as alternatives to broadcast pesticide application for control of a number of pest insects. This is an attract-and-kill pest management approach. With the development of female-targeted food-based synthetic attractants for tephritid fruit flies, a numbe...

Modeling and Analysis of Space Based Transceivers

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.; Liebetreu, John; Moore, Michael S.; Price, Jeremy C.; Abbott, Ben

2005-01-01

This paper presents the tool chain, methodology, and initial results of a study to provide a thorough, objective, and quantitative analysis of the design alternatives for space Software Defined Radio (SDR) transceivers. The approach taken was to develop a set of models and tools for describing communications requirements, the algorithm resource requirements, the available hardware, and the alternative software architectures, and generate analysis data necessary to compare alternative designs. The Space Transceiver Analysis Tool (STAT) was developed to help users identify and select representative designs, calculate the analysis data, and perform a comparative analysis of the representative designs. The tool allows the design space to be searched quickly while permitting incremental refinement in regions of higher payoff.

Modeling and Analysis of Space Based Transceivers

NASA Technical Reports Server (NTRS)

Moore, Michael S.; Price, Jeremy C.; Abbott, Ben; Liebetreu, John; Reinhart, Richard C.; Kacpura, Thomas J.

2007-01-01

This paper presents the tool chain, methodology, and initial results of a study to provide a thorough, objective, and quantitative analysis of the design alternatives for space Software Defined Radio (SDR) transceivers. The approach taken was to develop a set of models and tools for describing communications requirements, the algorithm resource requirements, the available hardware, and the alternative software architectures, and generate analysis data necessary to compare alternative designs. The Space Transceiver Analysis Tool (STAT) was developed to help users identify and select representative designs, calculate the analysis data, and perform a comparative analysis of the representative designs. The tool allows the design space to be searched quickly while permitting incremental refinement in regions of higher payoff.

Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools.

PubMed

Martínez-Montiel, Nancy; Anaya-Ruiz, Maricruz; Pérez-Santos, Martín; Martínez-Contreras, Rebeca D

2017-10-05

Alternative splicing is a key molecular mechanism now considered as a hallmark of cancer that has been associated with the expression of distinct isoforms during the onset and progression of the disease. The leading cause of cancer-related deaths in women worldwide is breast cancer, and even when the role of alternative splicing in this type of cancer has been established, the function of this mechanism in breast cancer biology is not completely decoded. In order to gain a comprehensive view of the role of alternative splicing in breast cancer biology and development, we summarize here recent findings regarding alternative splicing events that have been well documented for breast cancer evolution, considering its prognostic and therapeutic value. Moreover, we analyze how the response to endocrine and chemical therapies could be affected due to alternative splicing and differential expression of variant isoforms. With all this knowledge, it becomes clear that targeting alternative splicing represents an innovative approach for breast cancer therapeutics and the information derived from current studies could guide clinical decisions with a direct impact in the clinical advances for breast cancer patients nowadays.

The hydrologic implications of alternative prioritizations of landscape-scale geographically isolated wetlands conservation

NASA Astrophysics Data System (ADS)

Evenson, G. R.; Golden, H. E.; Lane, C.; Mclaughlin, D. L.; D'Amico, E.

2016-12-01

Geographically isolated wetlands (GIWs), defined as upland embedded wetlands, provide an array of ecosystem goods and services. Wetland conservation efforts aim to protect GIWs in the face of continued threats from anthropogenic activities. Given limited conservation resources, there is a critical need for methods capable of evaluating the watershed-scale hydrologic implications of alternative approaches to GIW conservation. Further, there is a need for methods that quantify the watershed-scale aggregate effects of GIWs to determine their regulatory status within the United States. We applied the Soil and Water Assessment Tool (SWAT), a popular watershed-scale hydrologic model, to represent the 1,700 km2 Pipestem Creek watershed in North Dakota, USA. We modified the model to incorporate an improved representation of GIW hydrologic processes via hydrologic response unit (HRU) redefinition and modifications to the model source code. We then used the model to evaluate the hydrologic effects of alternative approaches to GIW conservation prioritization by simulating the destruction/removal of GIWs by sub-classes defined by their relative position within the simulated fill-spill GIW network and their surface area characteristics. We evaluated the alternative conservation approaches as impacting (1) simulated streamflow at the Pipestem Creek watershed outlet; (2) simulated water-levels within the GIWs; and (3) simulated hydrologic connections between the GIWs. Our approach to modifying SWAT and evaluating alternative GIW conservation strategies may be replicated in different watersheds and physiographic regions to aid the development of GIW conservation priorities.

Development Of Educational Programs In Renewable And Alternative Energy Processing: The Case Of Russia

NASA Astrophysics Data System (ADS)

Svirina, Anna; Shindor, Olga; Tatmyshevsky, Konstantin

2014-12-01

The paper deals with the main problems of Russian energy system development that proves necessary to provide educational programs in the field of renewable and alternative energy. In the paper the process of curricula development and defining teaching techniques on the basis of expert opinion evaluation is defined, and the competence model for renewable and alternative energy processing master students is suggested. On the basis of a distributed questionnaire and in-depth interviews, the data for statistical analysis was obtained. On the basis of this data, an optimization of curricula structure was performed, and three models of a structure for optimizing teaching techniques were developed. The suggested educational program structure which was adopted by employers is presented in the paper. The findings include quantitatively estimated importance of systemic thinking and professional skills and knowledge as basic competences of a masters' program graduate; statistically estimated necessity of practice-based learning approach; and optimization models for structuring curricula in renewable and alternative energy processing. These findings allow the establishment of a platform for the development of educational programs.

Resiliency Programming for Adult Offenders in Georgia.

ERIC Educational Resources Information Center

Rees, E. Frances

2000-01-01

Discusses resiliency programming as an alternative approach to program development for incarcerated adults, and describes a pilot project in a Georgia prison, Leadership Development, that uses the concept of resiliency to frame inmate education. Discusses implications of this model of correctional education. (SLD)

Russia: update on animal experiments and alternatives in education.

PubMed

Jukes, Nick

2008-01-01

Progress continues in Russia with growing awareness and implementation of alternatives in education. Further outreach visits and negotiations for replacement have been made by InterNICHE campaigners. Russian language information resources have been complemented by the distribution of translated freeware physiology and pharmacology alternatives; and the InterNICHE Alternatives Loan Systems continue to provide valuable hands-on access to a range of learning tools. Donations of computers and alternatives have established exemplary multimedia laboratories, with software having directly replaced the annual use of several thousand animals. New agreements have been made with institutes to abandon animal experiments for teaching purposes. Work to consolidate the successes is being done, and Russian teachers have begun to present at conferences to share their experiences of implementation. Further development and implementation of alternatives is being achieved through grant funding from the InterNICHE Humane Education Award. Using a different approach, cases of determined conscientious objection have included a campaign against the use of stolen companion animals for surgery practice in the Russian Far East, and a continuing legal challenge to experiments at Moscow State University. This multi-pronged, decentralised and culturally appropriate campaigning strategy has proved to be an effective approach to achieving sustainable change in Russia.

Quantitative and qualitative approaches in the study of poverty and adolescent development: separation or integration?

PubMed

Leung, Janet T Y; Shek, Daniel T L

2011-01-01

This paper examines the use of quantitative and qualitative approaches to study the impact of economic disadvantage on family processes and adolescent development. Quantitative research has the merits of objectivity, good predictive and explanatory power, parsimony, precision and sophistication of analysis. Qualitative research, in contrast, provides a detailed, holistic, in-depth understanding of social reality and allows illumination of new insights. With the pragmatic considerations of methodological appropriateness, design flexibility, and situational responsiveness in responding to the research inquiry, a mixed methods approach could be a possibility of integrating quantitative and qualitative approaches and offers an alternative strategy to study the impact of economic disadvantage on family processes and adolescent development.

Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis

PubMed Central

Khoobchandani, Menka; Katti, Kavita; Maxwell, Adam; Fay, William P.; Katti, Kattesh V.

2016-01-01

In our efforts to develop new approaches to treat and prevent human vascular diseases, we report herein our results on the proliferation and migration of human smooth muscles cells (SMCs) and endothelial cells (ECs) using epigallocatechin-3-gallate conjugated gold nanoparticles (EGCg-AuNPs) as possible alternatives to drug coated stents. Detailed in vitro stability studies of EGCg-AuNPs in various biological fluids, affinity and selectivity towards SMCs and ECs have been investigated. The EGCg-AuNPs showed selective inhibitory efficacy toward the migration of SMCs. However, the endothelial cells remained unaffected under similar experimental conditions. The cellular internalization studies have indicated that EGCg-AuNPs internalize into the SMCs and ECs within short periods of time through laminin receptor mediated endocytosis mode. Favorable toxicity profiles and selective affinity toward SMCs and ECs suggest that EGCg-AuNPs may provide attractive alternatives to drug coated stents and therefore offer new therapeutic approaches in treating cardiovascular diseases. PMID:26938531

Comparison of Fertility Trends Estimated Alternatively from Birth Histories and Own Children. Papers of the East-West Population Institute, No. 94.

ERIC Educational Resources Information Center

Retherford, Robert D.; Alam, Iqbal

Fertility trends estimated alternately from birth histories and own children method are compared for eight developing countries in which the World Fertility Survey was conducted. Principle hypotheses are that fertility trends estimated by the two approaches suffer from similar errors in the reporting of women's and children's ages, and that these…

Alternative thermodynamic cycle for the Stirling machine

NASA Astrophysics Data System (ADS)

Romanelli, Alejandro

2017-12-01

We develop an alternative thermodynamic cycle for the Stirling machine, where the polytropic process plays a central role. Analytical expressions for pressure and temperatures of the working gas are obtained as a function of the volume and the parameter that characterizes the polytropic process. This approach achieves closer agreement with the experimental pressure-volume diagram and can be adapted to any type of Stirling engine.

Device and circuit analysis of a sub 20 nm double gate MOSFET with gate stack using a look-up-table-based approach

NASA Astrophysics Data System (ADS)

Chakraborty, S.; Dasgupta, A.; Das, R.; Kar, M.; Kundu, A.; Sarkar, C. K.

2017-12-01

In this paper, we explore the possibility of mapping devices designed in TCAD environment to its modeled version developed in cadence virtuoso environment using a look-up table (LUT) approach. Circuit simulation of newly designed devices in TCAD environment is a very slow and tedious process involving complex scripting. Hence, the LUT based modeling approach has been proposed as a faster and easier alternative in cadence environment. The LUTs are prepared by extracting data from the device characteristics obtained from device simulation in TCAD. A comparative study is shown between the TCAD simulation and the LUT-based alternative to showcase the accuracy of modeled devices. Finally the look-up table approach is used to evaluate the performance of circuits implemented using 14 nm nMOSFET.

Healthful Dietary Patterns and the Risk of Hypertension Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study.

PubMed

Li, Shanshan; Zhu, Yeyi; Chavarro, Jorge E; Bao, Wei; Tobias, Deirdre K; Ley, Sylvia H; Forman, John P; Liu, Aiyi; Mills, James; Bowers, Katherine; Strøm, Marin; Hansen, Susanne; Hu, Frank B; Zhang, Cuilin

2016-06-01

Women who developed gestational diabetes mellitus represent a high-risk population for hypertension later in life. The role of diet in the progression of hypertension among this susceptible population is unknown. We conducted a prospective cohort study of 3818 women with a history of gestational diabetes mellitus in the Nurses' Health Study II as part of the ongoing Diabetes & Women's Health Study. These women were followed-up from 1989 to 2011. Incident hypertension was identified through self-administered questionnaires that were validated previously by medical record review. Adherence scores for the alternative Healthy Eating Index 2010, the alternative Mediterranean diet, and the Dietary Approaches to Stop Hypertension were computed for each participant. Cox proportional hazard models were used to evaluate the associations between dietary scores and hypertension while adjusting for major risk factors for hypertension. We documented 1069 incident hypertension cases during a median of 18.5 years of follow-up. After adjustment for major risk factors for hypertension, including body mass index, alternative Healthy Eating Index 2010, alternative Mediterranean diet, and Dietary Approaches to Stop Hypertension scores were significantly inversely associated with the risk of hypertension; hazard ratio and 95% confidence interval comparing the extreme quartiles (highest versus lowest) were 0.76 (0.61-0.94; P for linear trend =0.03) for AHEI score, 0.72 (0.58-0.90; P for trend =0.01) for Dietary Approach to Stop Hypertension score, and 0.70 (0.56-0.88; P for trend =0.002) for alternative Mediterranean diet score. Adherence to a healthful dietary pattern was related to a lower subsequent risk of developing hypertension among women with a history of gestational diabetes mellitus. © 2016 American Heart Association, Inc.

The Process Genre Writing Approach; An Alternative Option for the Modern Classroom

ERIC Educational Resources Information Center

Tudor, Emma

2017-01-01

"Writing involves knowledge about the language, the context in which writing happens and skills in using language. Writing development happens by drawing out the learners' potential and providing input to which learners respond" (Badger & White, 2000.) Taking this in to account, the Process Genre Approach in writing classes can be…

Social Justice Intents in Policy: An Analysis of Capability "for" and "through" Education

ERIC Educational Resources Information Center

Gale, Trevor; Molla, Tebeje

2015-01-01

Primarily developed as an alternative to narrow measures of well-being such as utility and resources, Amartya Sen's capability approach places strong emphasis on people's substantive opportunities. As a broad normative framework, the capability approach has become a valuable tool for understanding and evaluating social arrangements (e.g. education…

An Integrated, Statistical Molecular Approach to the Physical Chemistry Curriculum

ERIC Educational Resources Information Center

Cartier, Stephen F.

2009-01-01

As an alternative to the "thermodynamics first" or "quantum first" approaches to the physical chemistry curriculum, the statistical definition of entropy and the Boltzmann distribution are introduced in the first days of the course and the entire two-semester curriculum is then developed from these concepts. Once the tools of statistical mechanics…

Inter-Method Reliability of School Effectiveness Measures: A Comparison of Value-Added and Regression Discontinuity Estimates

ERIC Educational Resources Information Center

Perry, Thomas

2017-01-01

Value-added (VA) measures are currently the predominant approach used to compare the effectiveness of schools. Recent educational effectiveness research, however, has developed alternative approaches including the regression discontinuity (RD) design, which also allows estimation of absolute school effects. Initial research suggests RD is a viable…

Mind Map Marketing: A Creative Approach in Developing Marketing Skills

ERIC Educational Resources Information Center

Eriksson, Lars Torsten; Hauer, Amie M.

2004-01-01

In this conceptual article, the authors describe an alternative course structure that joins learning key marketing concepts to creative problem solving. The authors describe an approach using a convergent-divergent-convergent (CDC) process: key concepts are first derived from case material to be organized in a marketing matrix, which is then used…

Critical Pedagogy in an EFL Teaching Context: An Ignis Fatuus or an Alternative Approach?

ERIC Educational Resources Information Center

Sadeghi, Sima

2008-01-01

Language teaching has, for much of its history, been subject to the heavy "evangelical zeal" of the centers who have exported their theories, methods derived from these, approaches, materials, and books to the developing countries "often with doubtful relevance to the sociological, educational and economic context of the Outer…

Cultural Capital and Innovative Pedagogy: A Case Study among Indigenous Communities in Mexico and Honduras

ERIC Educational Resources Information Center

Gregorcic, Marta

2009-01-01

This article introduces case studies of innovative approaches to pedagogy among indigenous Mayan communities in Chiapas (Mexico) and Lencan communities in Intibuca (Honduras). Innovative approaches to researching alternative theories and practices of pedagogy are used by the author to develop an epistemology of critical pedagogy and its potential…

A Short Term Therapy Approach to Processing Trauma: Art Therapy and Bilateral Stimulation

ERIC Educational Resources Information Center

Tripp, Tally

2007-01-01

This article describes a dynamic, short-term art therapy approach that has been developed for the treatment of trauma related disorders. Using a modified Eye Movement Desensitization and Reprocessing (EMDR) protocol with alternating tactile and auditory bilateral stimulation, associations are rapidly brought to conscious awareness and expressed in…

An alternative regionalization scheme for defining nutrient criteria for rivers and streams

USGS Publications Warehouse

Robertson, Dale M.; Saad, David A.; Wieben, Ann M.

2001-01-01

The environmental nutrient zone approach can be applied to specific states or nutrient ecoregions and used to develop criteria as a function of stream type. This approach can also be applied on the basis of environmental characteristics of the watershed alone rather than the general environmental characteristics from the region in which the site is located. The environmental nutrient zone approach will enable states to refine the basic nutrient criteria established by the USEPA by developing attainable criteria given the environmental characteristics where the streams are located.

An evaluation of some alternative approaches for reducing fan tone noise

NASA Astrophysics Data System (ADS)

Dittmar, James H.; Woodward, Richard P.

1992-02-01

The potential of two alternative approaches for reducing fan ton noise was investigated in this study. One of these approaches increases the number of rotor blades to shift the tone noise to higher frequencies that are not rated as strongly by the perceived noise scale. This alternative fan also would have a small number of long chord stator vanes which would reduce the stator response and lower rotor-stator interaction noise. Comparison of the conventional and alternative fan concepts showed that this alternative approach has as large or larger a perceived tone noise reduction potential as the conventional approach. The other alternative, a high Mach number inlet, is evaluated both for its noise attenuation and for its change in noise directivity.

Life support technology investment strategies for flight programs: An application of decision analysis

NASA Technical Reports Server (NTRS)

Schlater, Nelson J.; Simonds, Charles H.; Ballin, Mark G.

1993-01-01

Applied research and technology development (R&TD) is often characterized by uncertainty, risk, and significant delays before tangible returns are obtained. Given the increased awareness of limitations in resources, effective R&TD today needs a method for up-front assessment of competing technologies to help guide technology investment decisions. Such an assessment approach must account for uncertainties in system performance parameters, mission requirements and architectures, and internal and external events influencing a development program. The methodology known as decision analysis has the potential to address these issues. It was evaluated by performing a case study assessment of alternative carbon dioxide removal technologies for NASA's proposed First Lunar Outpost program. An approach was developed that accounts for the uncertainties in each technology's cost and performance parameters as well as programmatic uncertainties such as mission architecture. Life cycle cost savings relative to a baseline, adjusted for the cost of money, was used as a figure of merit to evaluate each of the alternative carbon dioxide removal technology candidates. The methodology was found to provide a consistent decision-making strategy for development of new life support technology. The case study results provided insight that was not possible from more traditional analysis approaches.

Fiscal year 1980-81 implementation plan in support of technical development and integration of sampling and aggregation procedures. [crop acreage estimation

NASA Technical Reports Server (NTRS)

1981-01-01

The specific objectives of the FY 1980-81 tasks are: (1) further refinements to the weighted aggregation procedure; (2) improved approaches for estimating within-stratum variance; (3) more intensive investigation of alternative sampling strategies such as full-frame sampling strategy, and (4) further developments in regard to a simulated approach for assessing the performance of the overall designed sampling and aggregation system.

ISSUES IN DEVELOPING A TWO-GENERATION AVIAN TOXICITY TEST WITH JAPANESE QUAIL

EPA Science Inventory

As a subgroup of the OECD Expert Group on Assessment of Endocrine Disrupting Effects in Birds, we reviewed unresolved methodological issures important for the development of a two-generation toxicity test, discussed advantages and disadvantages of alternative approaches, and prop...

Disentangling road network impacts: The need for a holistic approach

USDA-ARS?s Scientific Manuscript database

Traditional and alternative energy development, logging and mining activities, together with off-highway vehicles (OHV) and exurban development, have increased the density of linear disturbances on public and private lands throughout the world. We argue that the dramatic increase in linear disturba...

Unemployed Youth: Alternative Approaches to an African Crisis.

ERIC Educational Resources Information Center

Livingstone, Ian

1989-01-01

This article draws on the findings of seven country studies of youth employment programs in Africa (Botswana, Somalia, Zambia, Malawi, Kenya, Ethiopia, and Mauritius). Considered are public service/public works programs, agricultural development, employable skills development and vocationalization of education, and national youth services. (SK)

Scripting MODFLOW model development using Python and FloPy

USGS Publications Warehouse

Bakker, Mark; Post, Vincent E. A.; Langevin, Christian D.; Hughes, Joseph D.; White, Jeremy; Starn, Jeffrey; Fienen, Michael N.

2016-01-01

Graphical user interfaces (GUIs) are commonly used to construct and postprocess numerical groundwater flow and transport models. Scripting model development with the programming language Python is presented here as an alternative approach. One advantage of Python is that there are many packages available to facilitate the model development process, including packages for plotting, array manipulation, optimization, and data analysis. For MODFLOW-based models, the FloPy package was developed by the authors to construct model input files, run the model, and read and plot simulation results. Use of Python with the available scientific packages and FloPy facilitates data exploration, alternative model evaluations, and model analyses that can be difficult to perform with GUIs. Furthermore, Python scripts are a complete, transparent, and repeatable record of the modeling process. The approach is introduced with a simple FloPy example to create and postprocess a MODFLOW model. A more complicated capture-fraction analysis with a real-world model is presented to demonstrate the types of analyses that can be performed using Python and FloPy.

Theoretical and Ideological Framing: Relative Change Theory and Its Application to Humanitarianism in Education Development

ERIC Educational Resources Information Center

Omwami, Edith Mukudi

2012-01-01

This paper proposes relative change theory as an alternative to the common theories used in examining education sector development in the developing regions of the world. The theory specifically seeks to explain the persisting limited impact of development aid efforts. It departs from the Marxist informed dependency and world-systems approach in…

Admission Market Research: An Alternative to Decline in the Eighties.

ERIC Educational Resources Information Center

Lolli, Anthony; Scannell, James

1983-01-01

Institutional commitment, financial resources, and technical skills are essential components in meaningful, proactive marketing research. Some recently developed approaches and efforts illustrate the possibilities of such research. (MSE)

A cloud model based multi-attribute decision making approach for selection and evaluation of groundwater management schemes

NASA Astrophysics Data System (ADS)

Lu, Hongwei; Ren, Lixia; Chen, Yizhong; Tian, Peipei; Liu, Jia

2017-12-01

Due to the uncertainty (i.e., fuzziness, stochasticity and imprecision) existed simultaneously during the process for groundwater remediation, the accuracy of ranking results obtained by the traditional methods has been limited. This paper proposes a cloud model based multi-attribute decision making framework (CM-MADM) with Monte Carlo for the contaminated-groundwater remediation strategies selection. The cloud model is used to handle imprecise numerical quantities, which can describe the fuzziness and stochasticity of the information fully and precisely. In the proposed approach, the contaminated concentrations are aggregated via the backward cloud generator and the weights of attributes are calculated by employing the weight cloud module. A case study on the remedial alternative selection for a contaminated site suffering from a 1,1,1-trichloroethylene leakage problem in Shanghai, China is conducted to illustrate the efficiency and applicability of the developed approach. Totally, an attribute system which consists of ten attributes were used for evaluating each alternative through the developed method under uncertainty, including daily total pumping rate, total cost and cloud model based health risk. Results indicated that A14 was evaluated to be the most preferred alternative for the 5-year, A5 for the 10-year, A4 for the 15-year and A6 for the 20-year remediation.

Ecdysteroid and chitinase fluctuations in the western tarnished plant bug (Lygus hesperus) prior to molt indicate roles in development

USDA-ARS?s Scientific Manuscript database

Vital physiological processes that drive the insect molt represent areas of interest for the development of alternative control strategies. The western tarnished plant bug (Lygus hesperus Knight) is a pest of numerous agronomic and horticultural crops but the development of novel control approaches ...

Implications of Leader-Member Exchange Theory and Research for Human Resource Development Research.

ERIC Educational Resources Information Center

Burns, Janet Z.; Otte, Fred L.

1999-01-01

Leader/member exchange theory is proposed as an alternate approach to the study of organizational leadership. Recent research supports the theory but additional development work is needed. The theory seeks to explain how leader/member relationships develop and the behavioral components of leadership relations. Contains 74 references. (Author/JOW)

THz spectroscopy: An emerging technology for pharmaceutical development and pharmaceutical Process Analytical Technology (PAT) applications

NASA Astrophysics Data System (ADS)

Wu, Huiquan; Khan, Mansoor

2012-08-01

As an emerging technology, THz spectroscopy has gained increasing attention in the pharmaceutical area during the last decade. This attention is due to the fact that (1) it provides a promising alternative approach for in-depth understanding of both intermolecular interaction among pharmaceutical molecules and pharmaceutical product quality attributes; (2) it provides a promising alternative approach for enhanced process understanding of certain pharmaceutical manufacturing processes; and (3) the FDA pharmaceutical quality initiatives, most noticeably, the Process Analytical Technology (PAT) initiative. In this work, the current status and progress made so far on using THz spectroscopy for pharmaceutical development and pharmaceutical PAT applications are reviewed. In the spirit of demonstrating the utility of first principles modeling approach for addressing model validation challenge and reducing unnecessary model validation "burden" for facilitating THz pharmaceutical PAT applications, two scientific case studies based on published THz spectroscopy measurement results are created and discussed. Furthermore, other technical challenges and opportunities associated with adapting THz spectroscopy as a pharmaceutical PAT tool are highlighted.

The use of survey data to study migration–environment relationships in developing countries: alternative approaches to data collection

PubMed Central

Henry, Sabine J. F.

2014-01-01

Growing interest in the environmental aspects of migration is not matched by research on their interrelationships, due partly to the lack of adequate data sets on the two together. Focusing on the microlevel, we describe the data required to effectively investigate these interrelationships. Data sources are discussed, be collected, focusing on household surveys and remote sensing. The main section of the paper describes three alternative approaches to data collection: (a) using existing population and environmental data from different sources, illustrated by Burkina Faso; (b) adding questions to a survey developed for another purpose, illustrated for Guatemala using a DHS survey; and (c) designing a new survey specifically to collect both migration and environmental data to investigate interrelationships, illustrated by Ecuador. Methods used and summary findings are described, followed by a discussion of their advantages and limitations. We conclude with recommendations as to effective use of each approach as research on migration–environment linkages moves forward. PMID:24701002

40 CFR 1507.2 - Agency capability to comply.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., interdisciplinary approach which will insure the integrated use of the natural and social sciences and the... standards. (d) Study, develop, and describe alternatives to recommended courses of action in any proposal...

40 CFR 1507.2 - Agency capability to comply.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., interdisciplinary approach which will insure the integrated use of the natural and social sciences and the... standards. (d) Study, develop, and describe alternatives to recommended courses of action in any proposal...

40 CFR 1507.2 - Agency capability to comply.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., interdisciplinary approach which will insure the integrated use of the natural and social sciences and the... standards. (d) Study, develop, and describe alternatives to recommended courses of action in any proposal...

40 CFR 1507.2 - Agency capability to comply.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., interdisciplinary approach which will insure the integrated use of the natural and social sciences and the... standards. (d) Study, develop, and describe alternatives to recommended courses of action in any proposal...

40 CFR 1507.2 - Agency capability to comply.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., interdisciplinary approach which will insure the integrated use of the natural and social sciences and the... standards. (d) Study, develop, and describe alternatives to recommended courses of action in any proposal...

An alternative approach to modelling HbA1c trajectories in patients with type 2 diabetes mellitus.

PubMed

McEwan, Phil; Bennett, Hayley; Qin, Lei; Bergenheim, Klas; Gordon, Jason; Evans, Marc

2017-05-01

Time-dependent HbA1c trajectories in health economic models of type 2 diabetes mellitus (T2DM) are typically informed by the UK Prospective Diabetes Study (UKPDS). However, this approach may not accurately predict HbA1c progression in patients who do not conform to the demographic profile of the original UKPDS cohort. This study aimed to develop an alternative mathematical model (MM) to simulate HbA1c progression in T2DM. A systematic literature review identified studies, published between 2005 and 2015, that reported HbA1c in adult T2DM patients over a minimum duration of 18 months. Pooled data from eligible studies were used to develop an alternative MM equation for HbA1c progression, which was then contrasted with the UKPDS 68 progression equation in illustrative scenarios. A total of 68 studies were eligible for data extraction (mean follow-up time 4.1 years). HbA1c progression was highly heterogeneous across studies, varying with baseline HbA1c, treatment group and patient age. The MM equation was fitted with parameters for mean baseline HbA1c (8.3%), initial change in HbA1c (-0.62%) and upper quartile of maximum observed HbA1c (9.3%). Differences in HbA1c trajectories between the MM and UKPDS approaches altered the timing of therapy escalation in illustrative scenarios. The MM represents an alternative approach to simulate HbA1c trajectories in T2DM models, as UKPDS data may not adequately reflect the heterogeneity of HbA1c profiles observed in clinical studies. However, the choice of approach should ultimately be determined by the characteristics of individual patients under consideration and the clinical face validity of the modelled trajectories. © 2016 John Wiley & Sons Ltd.

A Cost Comparison of Alternative Approaches to Distance Education in Developing Countries

NASA Technical Reports Server (NTRS)

Ventre, Gerard G.; Kalu, Alex

1996-01-01

This paper presents a cost comparison of three approaches to two-way interactive distance learning systems for developing countries. Included are costs for distance learning hardware, terrestrial and satellite communication links, and designing instruction for two-way interactive courses. As part of this project, FSEC is developing a 30-hour course in photovoltaic system design that will be used in a variety of experiments using the Advanced Communications Technology Satellite (ACTS). A primary goal of the project is to develop an instructional design and delivery model that can be used for other education and training programs. Over two-thirds of the world photovoltaics market is in developing countries. One of the objectives of this NASA-sponsored project was to develop new and better energy education programs that take advantage of advances in telecommunications and computer technology. The combination of desktop video systems and the sharing of computer applications software is of special interest. Research is being performed to evaluate the effectiveness of some of these technologies as part of this project. The design of the distance learning origination and receive sites discussed in this paper were influenced by the educational community's growing interest in distance education. The following approach was used to develop comparative costs for delivering interactive distance education to developing countries: (1) Representative target locations for receive sites were chosen. The originating site was assumed to be Cocoa, Florida, where FSEC is located; (2) A range of course development costs were determined; (3) The cost of equipment for three alternative two-way interactive distance learning system configurations was determined or estimated. The types of system configurations ranged from a PC-based system that allows instructors to originate instruction from their office using desktop video and shared application software, to a high cost system that uses a electronic classroom; (4) A range of costs for both satellite and terrestrial communications was investigated; (5) The costs of equipment and operation of the alternative configurations for the origination and receive sites were determined; (6) A range of costs for several alternative delivery scenarios (i.e., a mix of live-interactive; asynchronous interactive;use of videotapes) was determined; and (7) A preferred delivery scenario, including cost estimate, was developed.

Pathogen Treatment Guidance and Monitoring Approaches fro ...

EPA Pesticide Factsheets

On-site non-potable water reuse is increasingly used to augment water supplies, but traditional fecal indicator approaches for defining and monitoring exposure risks are limited when applied to these decentralized options. This session emphasizes risk-based modeling to define pathogen log-reduction requirements coupled with alternative targets for monitoring enabled by genomic sequencing (i.e., the microbiome of reuse systems). 1. Discuss risk-based modeling to define pathogen log-reduction requirements 2. Review alternative targets for monitoring 3. Gain an understanding of how new tools can help improve successful development of sustainable on-site non-potable water reuse Presented at the Water Wastewater Equipment Treatment & Transport Show.

Performance analysis of a diesel engine driven brushless alternator with combined AC and thyristor fed DC loads through PSPICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, S.S.Y.; Ananthakrishnan, P.; Hangari, V.U.

1995-12-31

A brushless alternator with damper windings in the main alternator and with combined ac and thyristor fed dc loads has been handled ab initio as a total modeling and simulation problem for which a complete steady state performance prediction algorithm has been developed through proper application of Park`s equivalent circuit approach individually to the main and exciter alternator units of the brushless alternator. Details of the problems faced during implementation of this algorithm through PSPICE for the case of a specific 125 kVA brushless alternator as well as methods adopted for successfully overcoming the same have then been presented. Finallymore » a comparison of the predicted performance with those obtained experimentally for this 125 kVA unit has also been provided for the cases of both thyristor fed dc load alone as well as combined ac and thyristor fed dc loads. To enable proper calculation of derating factors to be used in the design of such brushless alternators, the simulation results then include harmonic analysis of the alternator output voltage and current waveforms at the point of common connection of the ac and thyristor fed dc load, damper winding currents, main alternator field winding current, exciter alternator armature voltage and the alternator developed torque and torque angle pulsations.« less

Earth Observatory Satellite system definition study. Report no. 4: Management approach recommendations

NASA Technical Reports Server (NTRS)

1974-01-01

A management approach for the Earth Observatory Satellite (EOS) which will meet the challenge of a constrained cost environment is presented. Areas of consideration are contracting techniques, test philosophy, reliability and quality assurance requirements, commonality options, and documentation and control requirements. The various functional areas which were examined for cost reduction possibilities are identified. The recommended management approach is developed to show the primary and alternative methods.

Community-Based Rehabilitation (CBR): Problems and Possibilities.

ERIC Educational Resources Information Center

O'Toole, Brian

1987-01-01

The institution-based model for providing services to individuals with disabilities has limitations in both developing and developed countries. The community-based rehabilitation model was positively evaluated by the World Health Organization as an alternative approach, but the evaluation is questioned on methodological and philosophical grounds.…

Cost Benefit Analysis of Enterprise Resource Planning System for the Naval Postgraduate School

DTIC Science & Technology

2002-06-01

Department-wide introduction and use of appropriate commercial financial practices and reporting • Develop a strategic plan for implementing a business... Development of a process innovation approach given the current capabilities of the system, recommend possible alternatives to close gaps. E

The environmental management problem of Pohorje, Slovenia: A new group approach within ANP - SWOT framework.

PubMed

Grošelj, Petra; Zadnik Stirn, Lidija

2015-09-15

Environmental management problems can be dealt with by combining participatory methods, which make it possible to include various stakeholders in a decision-making process, and multi-criteria methods, which offer a formal model for structuring and solving a problem. This paper proposes a three-phase decision making approach based on the analytic network process and SWOT (strengths, weaknesses, opportunities and threats) analysis. The approach enables inclusion of various stakeholders or groups of stakeholders in particular stages of decision making. The structure of the proposed approach is composed of a network consisting of an objective cluster, a cluster of strategic goals, a cluster of SWOT factors and a cluster of alternatives. The application of the suggested approach is applied to a management problem of Pohorje, a mountainous area in Slovenia. Stakeholders from sectors that are important for Pohorje (forestry, agriculture, tourism and nature protection agencies) who can offer a wide range of expert knowledge were included in the decision-making process. The results identify the alternative of "sustainable development" as the most appropriate for development of Pohorje. The application in the paper offers an example of employing the new approach to an environmental management problem. This can also be applied to decision-making problems in various other fields. Copyright © 2015 Elsevier Ltd. All rights reserved.

Re-powering and site recycling in a competitive environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, A.; Kahn, E.P.

1991-03-01

Re-powering and site recycling are strategies designed to expand electric generating capacity by using depreciated assets. The resource base for the these strategies is large. By 1995, over 170,000 MW of fossil-fired capacity will be in excess of thirty years old, and approaching the end of its conventional economic lifetime. This paper explores how these assets might be developed using competitive market forces. While some re-powering is being pursued under traditional ratebase regulation, there are four other generic alternatives. These are: (1) utility investment at fixed prices with regulatory pre-approval, (2) utility investment under competitive bidding, (3) utility leasing formore » private producer development, and (4) utility sale of sites for private producer development. Issues associated with each alternative are explored and illustrated with examples. State regulatory policy will be the critical determinant of whether a market develops for depreciated power plants. Financial incentives will stimulate utilities to re-deploy depreciated assets. This means some form of profit-sharing between customers and shareholders of the grains from asset sales. Different approaches to profit sharing are reviewed. These developments are still in an experimental state, however, and no single approach appears to have emerged as a dominant trend. 36 refs., 1 tab.« less

Surgical Approaches to Aortic Valve Replacement and Repair—Insights and Challenges

PubMed Central

Ramchandani, Mahesh; Reardon, Michael J

2014-01-01

Since 1960, surgical aortic valve replacement (sAVR) had been the only effective treatment for symptomatic severe aortic stenosis until the recent development of transcatheter aortic valve replacement (TAVR). TAVR has offered an alternative, minimally invasive treatment approach particularly for patients whose age or co-morbidities make them unsuitable for sAVR. The rapid and enthusiastic utilization of this new technique has triggered some speculation about the imminent demise of sAVR. We believe that despite the recent advances in TAVR, surgical approach to aortic valve replacement has continued to develop and will continue to be highly relevant in the future. This article will discuss the recent developments and current approaches for sAVR, and how these approaches will keep pace with catheter-based technologies. PMID:29588775

Harmonisation of animal testing alternatives in China.

PubMed

Cheng, Shujun; Qu, Xiaoting; Qin, Yao

2017-12-01

More and more countries are lining up to follow the EU's approach and implement a full ban on the sale of cosmetics that have been tested on animals, which has been the case in the EU since 2013. Besides animal welfare considerations, the need for mutual acceptance of data (MAD) and harmonisation of the global market have made the move toward non-animal testing a desirable general trend for countries worldwide. Over the last 10 years, the concept of alternative methods has been gradually developing in China. This has seen the harmonisation of relevant legislation, the organisation of various theoretical and hands-on training sessions, the exploration of method validation, the adoption of internationally recognised methods, the propagation of alternative testing standards, and an in-depth investigation into the potential use of in vitro methods in the biosciences. There are barriers to this progress, including the demand for a completely new infrastructure, the need to build technology capability, the requirement for a national standardisation system formed through international co-operation, and the lack of technical assistance to facilitate self-innovation. China is now increasing speed in harmonising its approach to the use of non-animal alternatives, accelerating technological development and attempting to incorporate non-animal, in vitro, testing methods into the national regulatory system.

Incorporating Alternative Care Site Characteristics Into Estimates of Substitutable ED Visits.

PubMed

Trueger, Nathan Seth; Chua, Kao-Ping; Hussain, Aamir; Liferidge, Aisha T; Pitts, Stephen R; Pines, Jesse M

2017-07-01

Several recent efforts to improve health care value have focused on reducing emergency department (ED) visits that potentially could be treated in alternative care sites (ie, primary care offices, retail clinics, and urgent care centers). Estimates of the number of these visits may depend on assumptions regarding the operating hours and functional capabilities of alternative care sites. However, methods to account for the variability in these characteristics have not been developed. To develop methods to incorporate the variability in alternative care site characteristics into estimates of ED visit "substitutability." Our approach uses the range of hours and capabilities among alternative care sites to estimate lower and upper bounds of ED visit substitutability. We constructed "basic" and "extended" criteria that captured the plausible degree of variation in each site's hours and capabilities. To illustrate our approach, we analyzed data from 22,697 ED visits by adults in the 2011 National Hospital Ambulatory Medical Care Survey, defining a visit as substitutable if it was treat-and-release and met both the operating hours and functional capabilities criteria. Use of the combined basic hours/basic capabilities criteria and extended hours/extended capabilities generated lower and upper bounds of estimates. Our criteria classified 5.5%-27.1%, 7.6%-20.4%, and 10.6%-46.0% of visits as substitutable in primary care offices, retail clinics, and urgent care centers, respectively. Alternative care sites vary widely in operating hours and functional capabilities. Methods such as ours may help incorporate this variability into estimates of ED visit substitutability.

Personality disorders in DSM-5: emerging research on the alternative model.

PubMed

Morey, Leslie C; Benson, Kathryn T; Busch, Alexander J; Skodol, Andrew E

2015-04-01

The current categorical classification of personality disorders, originally introduced in the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), has been found to suffer from numerous shortcomings that hamper its usefulness for research and for clinical application. The Personality and Personality Disorders Work Group for DSM-5 was charged with developing an alternative model that would address many of these concerns. The developed model involved a hybrid dimensional/categorical model that represented personality disorders as combinations of core impairments in personality functioning with specific configurations of problematic personality traits. The Board of Trustees of the American Psychiatric Association did not accept the Task Force recommendation to implement this novel approach, and thus this alternative model was included in Sect. III of the DSM-5 among concepts requiring additional study. This review provides an overview of the emerging research on this alternative model, addressing each of the primary components of the model.

Geographic Education for Spaceship Earth

ERIC Educational Resources Information Center

Blachford, Kevin

1974-01-01

Six unsatisfactory ways of approaching geographic concepts in the classroom are presented. An alternative that would promote global-mindedness and the development of accurate mental maps in students is discussed in terms of teaching techniques. (JH)

A Study to Develop Alternative Approaches for Implementing Product Line Management in the South Texas Veterans Health Care System

DTIC Science & Technology

1997-05-01

Transformation of the Veterans Healthcare System." Department of Veterans Affairs, Washington, D.C., March, 1996. 88 Kotler , Philip . "Managing...time lines are developed so management and staff can begin thinking about business from a different perspective (Manning 1987,29). Philip Lathrop...organized around product lines will the full effects of this approach be known. 86 WORKS CITED Benz, Philip D., and Janet Burnham. "Case Study

MOOCs from the Viewpoint of the Learner: A Response to Perna et al. (2014)

ERIC Educational Resources Information Center

Wiebe, Eric; Thompson, Isaac; Behrend, Tara

2015-01-01

This response to Perna et al. provides an alternate approach to research on massive open online courses (MOOCs). We argue that a student-centered, theory-driven conceptualization and methodological approaches allow us to move beyond descriptive statistics and into a deeper understanding of MOOC learners. Examples using a teacher development MOOC…

"L2 Assessment and Testing" Teacher Education: An Exploration of Alternative Assessment Approaches Using New Technologies

ERIC Educational Resources Information Center

Papadima-Sophocleous, Salomi

2017-01-01

Most Second Language (L2) Teacher Training Assessment and Testing courses focus on testing. Through the development of a Master of Arts (MA) in a computer assisted language learning module (based on a constructivist and "practise what you preach" approach, entailing that the teachers experience firsthand the assessment types they were…

An ecosystem model for tropical forest disturbance and selective logging

Treesearch

Maoyi Huang; Gregory P. Asner; Michael Keller; Joseph A. Berry

2008-01-01

[1] A new three-dimensional version of the Carnegie-Ames-Stanford Approach (CASA) ecosystem model (CASA-3D) was developed to simulate regional carbon cycling in tropical forest ecosystems after disturbances such as logging. CASA-3D has the following new features: (1) an alternative approach for calculating absorbed photosynthetically active radiation (APAR) using new...

Haraway's "Bag Lady Story-Telling": Relocating Childhood and Learning within a "Post-Human Landscape"

ERIC Educational Resources Information Center

Taylor, Affrica; Blaise, Mindy; Giugni, Miriam

2013-01-01

In this article, we explore some alternate ways of approaching childhood and learning by taking three short forays into what Donna Haraway calls a "post-human landscape". This exploration takes us beyond the horizons of orthodox educational approaches, in which the individual child is typically seen to be developing and learning within…

Evaluation Approaches to Intelligent Computer-Assisted Instruction. Testing Study Group: The Impact of Advances in Artificial Intelligence on Test Development.

ERIC Educational Resources Information Center

Baker, Eva L.

Some special problems associated with evaluating intelligent computer-assisted instruction (ICAI) programs are addressed. This paper intends to describe alternative approaches to the assessment and improvement of such applications and to provide examples of efforts undertaken and shortfalls. Issues discussed stem chiefly from the technical demands…

Three Approaches to Preschoolers' Social and Emotional Competence: A Summary of Impact and Implementation Findings from Head Start CARES

ERIC Educational Resources Information Center

MDRC, 2015

2015-01-01

This summary describes the Head Start CARES research project, which evaluated three classroom-based approaches to enhancing children's social-emotional development: (1) The Incredible Years Teacher Training Program; (2) Preschool PATHS (Promoting Alternative Thinking Strategies); and (3) Tools of the Mind--Play. The three social-emotional…

The Case Study Method: Guidelines, Practices, and Applications for Vocational Education. Research and Development Series No. 189.

ERIC Educational Resources Information Center

Spirer, Janet E.

In comparison with traditional experimental design, which is concerned with what happened, a case study approach is more appropriate for answering the question of why or how something happened. As an alternative complementary-vocational-education-evaluation approach, the case study attempts to describe and analyze some program in comprehensive…

Supermath: An Alternative Approach to Improving Math Performance in Grades 4 through 9

ERIC Educational Resources Information Center

Pogrow, Stanley

2004-01-01

In this article, the author shares a decade's worth of experience in developing an approach to teaching math to upper-elementary and middle school students that simultaneously increases basic skills, improves problem solving, raises test scores, and sparks student interest in math. Sections include: (1) Background Of Supermath; (2) Description Of…

Using Narratives to Develop Standards for Leaders: Applying an Innovative Approach in Western Australia

ERIC Educational Resources Information Center

Wildy, Helen; Pepper, Coral

2005-01-01

Dissatisfaction with long lists of duties as substitutes for standards led to the innovative application of narratives as an alternative approach to the generation and use of standards for school leaders. This paper describes research conducted over nearly a decade in collaboration with the state education authority in Western Australia,…

A Machine Learning Approach to Student Modeling. Technical Report No. 1. Annual Report, 11/82-11/83.

ERIC Educational Resources Information Center

Langley, Pat; And Others

The notion of buggy procedures has played an important role in recent cognitive models of mathematical skills. Some earlier work on student modeling used artificial intelligence methods to automatically construct buggy models of student behavior. An alternate approach, proposed here, draws on insights from the rapidly developing field of machine…

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation.

PubMed

McNamee, Pauline; Hibatallah, Jalila; Costabel-Farkas, Margit; Goebel, Carsten; Araki, Daisuke; Dufour, Eric; Hewitt, Nicola J; Jones, Penny; Kirst, Annette; Le Varlet, Béatrice; Macfarlane, Martin; Marrec-Fairley, Monique; Rowland, Joanna; Schellauf, Florian; Scheel, Julia

2009-07-01

The need for alternative approaches to replace the in vivo rabbit Draize eye test for evaluation of eye irritation of cosmetic ingredients has been recognised by the cosmetics industry for many years. Extensive research has lead to the development of several assays, some of which have undergone formal validation. Even though, to date, no single in vitro assay has been validated as a full replacement for the rabbit Draize eye test, organotypic assays are accepted for specific and limited regulatory purposes. Although not formally validated, several other in vitro models have been used for over a decade by the cosmetics industry as valuable tools in a weight of evidence approach for the safety assessment of ingredients and finished products. In light of the deadlines established in the EU Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision-tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. Furthermore, recommendations are given on how remaining data gaps and research needs can be addressed.

Biological tooth replacement

PubMed Central

Sartaj, Rachel; Sharpe, Paul

2006-01-01

Teeth develop from a series of reciprocal interactions that take place between epithelium and mesenchyme during development of the mouth that begin early in mammalian embryogenesis. The molecular control of key processes in tooth development such as initiation, morphogenesis and cytodifferentiation are being increasingly better understood, to the point where this information can be used as the basis for approaches to produce biological replacement teeth (BioTeeth). This review outlines the current approaches, ideas and progress towards the production of BioTeeth that could form an alternative method for replacing lost or damaged teeth. PMID:17005022

Newcomers Developing English Literacy through Historical Thinking and Digitized Primary Sources

ERIC Educational Resources Information Center

Franquiz, Maria E.; Salinas, Cinthia S.

2011-01-01

The traditional approach to the education of newcomer students separates English language development from content instruction. It is assumed that English language proficiency is a prerequisite for subject-matter learning. The authors take the alternate view that the integration of historical thinking and digitized primary sources enhances English…

Planning for Applications of Communications Satellites in Education.

ERIC Educational Resources Information Center

O'Connell, William K.

This report of a project to develop and test a prototype system for the delivery of continuing education (CE) to two defined target groups of registered dietitians includes user needs, alternative approaches, the operational plan, the management plan, and personnel. Major tasks involved in the project are described: (1) development,…

Tactile Sensing Reflexes for Advanced Prosthetic Hands

DTIC Science & Technology

2016-10-01

mos.) 100% • Design and build “mechanical egg ” test equipment (1-2 mos.) (Abandoned, alternate approach developed) • Develop experimental protocol...of a “mechanical egg ” or force measuring object was rejected in favor of this common cracker. Page 6 • A comprehensive bench top study was

Wikis for Building Content Knowledge in the Foreign Language Classroom

ERIC Educational Resources Information Center

Pellet, Stephanie H.

2012-01-01

Most pedagogical applications of wikis in foreign language education draw on this collaborative tool to improve (formal) writing skills or to develop target language cultural sensitivity, missing largely on the opportunity to support student-developed L2 content knowledge. Seeking an alternative to traditional teacher-centered approaches, this…

Universalizing Education: Strategies for the Development and Use of Instructional Materials.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and Oceania.

The deliberations of representatives from eleven Asian Unesco member countries focus on alternative approaches to identification of needs and resources as a basis for curriculum development, strategies and methodologies adopted in translating the curriculum into teaching learning materials and learning aids, training of teachers, problems involved…

Integrative Medical Education: Development and Implementation of a Comprehensive Curriculum at the University of Arizona.

ERIC Educational Resources Information Center

Maizes, Victoria; Schneider, Craig; Bell, Iris; Weil, Andrew

2002-01-01

Describes the University of Arizona's approach to developing and implementing a comprehensive curriculum in integrative medicine, which integrates the best of complementary and alternative medicine (CAM) with the best of conventional medicine. Describes the curriculum, educational programs, clinical education, goals, and results, and suggests…

Ajax and Firefox: New Web Applications and Browsers

ERIC Educational Resources Information Center

Godwin-Jones, Bob

2005-01-01

Alternative browsers are gaining significant market share, and both Apple and Microsoft are releasing OS upgrades which portend some interesting changes in Web development. Of particular interest for language learning professionals may be new developments in the area of Web browser based applications, particularly using an approach dubbed "Ajax."…

An Approach to the Teaching of Academic Writing.

ERIC Educational Resources Information Center

Johnston, Sue Ann

1985-01-01

Discusses solutions to problems in teaching research paper writing skills to English as a second language students in developing countries where library resources are inadequate. Suggests the use of interviews as an alternative research source and shows how an oral report on research results can help to develop synthesizing skills. (SED)

Developing Resilient Agency in Learning: The Internal Structure of Learning Power

ERIC Educational Resources Information Center

Deakin Crick, Ruth; Huang, Shaofu; Ahmed Shafi, Adeela; Goldspink, Chris

2015-01-01

Understanding students' learning dispositions has been a focus for research in education for many years. A range of alternative approaches to conceptualising and measuring this broad construct have been developed. Traditional psychometric measures aim to produce scales that satisfy the requirements for research; however, such measures have an…

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

PubMed Central

Kane, Trevor L.; Carothers, Katelyn E.; Lee, Shaun W.

2018-01-01

Background Staphylococcus aureus is a major bacterial pathogen capable of causing a range of infections in humans from gastrointestinal disease, skin and soft tissue infections, to severe outcomes such as sepsis. Staphylococcal infections in humans can be frequent and recurring, with treatments becoming less effective due to the growing persistence of antibiotic resistant S. aureus strains. Due to the prevalence of antibiotic resistance, and the current limitations on antibiotic development, an active and highly promising avenue of research has been to develop strategies to specifically inhibit the activity of virulence factors produced S. aureus as an alternative means to treat disease. Objective In this review we specifically highlight several major virulence factors produced by S. aureus for which recent advances in antivirulence approaches may hold promise as an alternative means to treating diseases caused by this pathogen. Strategies to inhibit virulence factors can range from small molecule inhibitors, to antibodies, to mutant and toxoid forms of the virulence proteins. Conclusion The major prevalence of antibiotic resistant strains of S. aureus combined with the lack of new antibiotic discoveries highlight the need for vigorous research into alternative strategies to combat diseases caused by this highly successful pathogen. Current efforts to develop specific antivirulence strategies, vaccine approaches, and alternative therapies for treating severe disease caused by S. aureus have the potential to stem the tide against the limitations that we face in the post-antibiotic era. PMID:27894236

Talent Development as an Ecology of Games: A Case Study of Norwegian Handball

ERIC Educational Resources Information Center

Bjørndal, Christian Thue; Ronglan, Lars Tore; Andersen, Svein S.

2017-01-01

Structured talent identification and development, it has been argued, is one of the foundations of international sporting success and many modern elite sport systems have applied normative talent development (TD) models. The success of Norwegian handball, however, is based on an alternative approach to TD. Norwegian handball is characterized by a…

HIGH THROUGHPUT ASSESSMENTS OF CONVENTIONAL AND ALTERNATIVE COMPOUNDS

EPA Science Inventory

High throughput approaches for quantifying chemical hazard, exposure, and sustainability have the potential to dramatically impact the pace and nature of risk assessments. Integrated evaluation strategies developed at the US EPA incorporate inherency,bioactivity,bioavailability, ...

The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond.

PubMed

Cozigou, Gwenole; Crozier, Jonathan; Hendriksen, Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

2015-03-01

Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public-private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders. Through a brief description of EPAA's activities and organizational structure, we first articulate the value of this collaboration; we then focus on 2 key projects driven by EPAA. The first project aims to address research gaps on stem cells for safety testing, whereas the second project strives for an approach toward demonstration of consistency in vaccine batch release testing. We highlight the growing need for harmonization of international acceptance and implementation of alternative approaches and for increased international collaboration to foster progress on nonanimal alternatives.

Fault detection techniques for complex cable shield topologies

NASA Astrophysics Data System (ADS)

Coonrod, Kurt H.; Davis, Stuart L.; McLemore, Donald P.

1994-09-01

This document presents the results of a basic principles study which investigated technical approaches for developing fault detection techniques for use on cables with complex shielding topologies. The study was limited to those approaches which could realistically be implemented on a fielded cable, i.e., approaches which would require partial disassembly of a cable were not pursued. The general approach used was to start with present transfer impedance measurement techniques and modify their use to achieve the best possible measurement range. An alternative test approach, similar to a sniffer type test, was also investigated.

A Practical Approach to Address Uncertainty in Stakeholder Deliberations.

PubMed

Gregory, Robin; Keeney, Ralph L

2017-03-01

This article addresses the difficulties of incorporating uncertainty about consequence estimates as part of stakeholder deliberations involving multiple alternatives. Although every prediction of future consequences necessarily involves uncertainty, a large gap exists between common practices for addressing uncertainty in stakeholder deliberations and the procedures of prescriptive decision-aiding models advanced by risk and decision analysts. We review the treatment of uncertainty at four main phases of the deliberative process: with experts asked to describe possible consequences of competing alternatives, with stakeholders who function both as individuals and as members of coalitions, with the stakeholder committee composed of all stakeholders, and with decisionmakers. We develop and recommend a model that uses certainty equivalents as a theoretically robust and practical approach for helping diverse stakeholders to incorporate uncertainties when evaluating multiple-objective alternatives as part of public policy decisions. © 2017 Society for Risk Analysis.

Material flow-based economic assessment of landfill mining processes.

PubMed

Kieckhäfer, Karsten; Breitenstein, Anna; Spengler, Thomas S

2017-02-01

This paper provides an economic assessment of alternative processes for landfill mining compared to landfill aftercare with the goal of assisting landfill operators with the decision to choose between the two alternatives. A material flow-based assessment approach is developed and applied to a landfill in Germany. In addition to landfill aftercare, six alternative landfill mining processes are considered. These range from simple approaches where most of the material is incinerated or landfilled again to sophisticated technology combinations that allow for recovering highly differentiated products such as metals, plastics, glass, recycling sand, and gravel. For the alternatives, the net present value of all relevant cash flows associated with plant installation and operation, supply, recycling, and disposal of material flows, recovery of land and landfill airspace, as well as landfill closure and aftercare is computed with an extensive sensitivity analyses. The economic performance of landfill mining processes is found to be significantly influenced by the prices of thermal treatment (waste incineration as well as refuse-derived fuels incineration plant) and recovered land or airspace. The results indicate that the simple process alternatives have the highest economic potential, which contradicts the aim of recovering most of the resources. Copyright © 2016 Elsevier Ltd. All rights reserved.

Environmental strategies: A case study of systematic evaluation

NASA Astrophysics Data System (ADS)

Sherman, Douglas J.; Garès, Paul A.

1982-09-01

A major problem facing environmental managers is the necessity to effectively evaluate management alternatives. Traditional environmental assessments have emphasized the use of economic analyses. These approaches are often deficient due to difficulty in assigning dollar values to environmental systems and to social amenities. A more flexible decisionmaking model has been developed to analyze management options for coping with beach erosion problems at the Sandy Hook Unit of Gateway National Recreation Area in New Jersey. This model is comprised of decision-making variables which are formulated from a combination of environmental and management criteria, and it has an accept-reject format in which the management options are analyzed in terms of the variables. Through logical ordering of the insertion of the variables into the model, stepwise elimination of alternatives is possible. A hierarchy of variables is determined through estimating work required to complete an assessment of the alternatives for each variable. The assessment requiring the least work is performed first so that the more difficult evaluation will be limited to fewer alternatives. The application of this approach is illustrated with a case study in which beach protection alternatives were evaluated for the United States National Park Service.

A 3-D Magnetic Analysis of a Linear Alternator For a Stirling Power System

NASA Technical Reports Server (NTRS)

Geng, Steven M.; Schwarze, Gene E.; Niedra, Janis M.

2000-01-01

The NASA Glenn Research Center and the Department of Energy (DOE) are developing advanced radioisotope Stirling convertors, under contract with Stirling Technology Company (STC), for space applications. Of critical importance to the successful development of the Stirling convertor for space power applications is the development of a lightweight and highly efficient linear alternator. This paper presents a 3-D finite element method (FEM) approach for evaluating Stirling convertor linear alternators. Preliminary correlations with open-circuit voltage measurements provide an encouraging level of confidence in the model. Spatial plots of magnetic field strength (H) are presented in the region of the exciting permanent magnets. These plots identify regions of high H, where at elevated temperature and under electrical load, the potential to alter the magnetic moment of the magnets exists. This implies the need for further testing and analysis.

Country report: Broiler industry and broiler litter-related problems in the southeastern United States.

PubMed

Paudel, Krishna P; McIntosh, Christopher S

2005-01-01

This report describes the development of the broiler litter problem in the southeastern United States, including the economic opportunity and environmental challenges brought to the region by the industry. Through an analysis applied to the State of Georgia, land application of litter as a disposal alternative is examined along with its associated benefits. The analysis indicates that litter could be transported economically up to 256 km for cropland application. Excessive broiler litter production in a few concentrated regions is expected to stimulate the development of alternative approaches to broiler litter management, such as electricity generation.

Cost-effectiveness analysis of risk-reduction measures to reach water safety targets.

PubMed

Lindhe, Andreas; Rosén, Lars; Norberg, Tommy; Bergstedt, Olof; Pettersson, Thomas J R

2011-01-01

Identifying the most suitable risk-reduction measures in drinking water systems requires a thorough analysis of possible alternatives. In addition to the effects on the risk level, also the economic aspects of the risk-reduction alternatives are commonly considered important. Drinking water supplies are complex systems and to avoid sub-optimisation of risk-reduction measures, the entire system from source to tap needs to be considered. There is a lack of methods for quantification of water supply risk reduction in an economic context for entire drinking water systems. The aim of this paper is to present a novel approach for risk assessment in combination with economic analysis to evaluate risk-reduction measures based on a source-to-tap approach. The approach combines a probabilistic and dynamic fault tree method with cost-effectiveness analysis (CEA). The developed approach comprises the following main parts: (1) quantification of risk reduction of alternatives using a probabilistic fault tree model of the entire system; (2) combination of the modelling results with CEA; and (3) evaluation of the alternatives with respect to the risk reduction, the probability of not reaching water safety targets and the cost-effectiveness. The fault tree method and CEA enable comparison of risk-reduction measures in the same quantitative unit and consider costs and uncertainties. The approach provides a structured and thorough analysis of risk-reduction measures that facilitates transparency and long-term planning of drinking water systems in order to avoid sub-optimisation of available resources for risk reduction. Copyright © 2010 Elsevier Ltd. All rights reserved.

MAGDM linear-programming models with distinct uncertain preference structures.

PubMed

Xu, Zeshui S; Chen, Jian

2008-10-01

Group decision making with preference information on alternatives is an interesting and important research topic which has been receiving more and more attention in recent years. The purpose of this paper is to investigate multiple-attribute group decision-making (MAGDM) problems with distinct uncertain preference structures. We develop some linear-programming models for dealing with the MAGDM problems, where the information about attribute weights is incomplete, and the decision makers have their preferences on alternatives. The provided preference information can be represented in the following three distinct uncertain preference structures: 1) interval utility values; 2) interval fuzzy preference relations; and 3) interval multiplicative preference relations. We first establish some linear-programming models based on decision matrix and each of the distinct uncertain preference structures and, then, develop some linear-programming models to integrate all three structures of subjective uncertain preference information provided by the decision makers and the objective information depicted in the decision matrix. Furthermore, we propose a simple and straightforward approach in ranking and selecting the given alternatives. It is worth pointing out that the developed models can also be used to deal with the situations where the three distinct uncertain preference structures are reduced to the traditional ones, i.e., utility values, fuzzy preference relations, and multiplicative preference relations. Finally, we use a practical example to illustrate in detail the calculation process of the developed approach.

ACCELERATED SOLVENT EXTRACTION COMBINED WITH ...

EPA Pesticide Factsheets

A research project was initiated to address a recurring problem of elevated detection limits above required risk-based concentrations for the determination of semivolatile organic compounds in high moisture content solid samples. This project was initiated, in cooperation with the EPA Region 1 Laboratory, under the Regional Methods Program administered through the ORD Office of Science Policy. The aim of the project was to develop an approach for the rapid removal of water in high moisture content solids (e.g., wetland sediments) in preparation for analysis via Method 8270. Alternative methods for water removal have been investigated to enhance compound solid concentrations and improve extraction efficiency, with the use of pressure filtration providing a high-throughput alternative for removal of the majority of free water in sediments and sludges. In order to eliminate problems with phase separation during extraction of solids using Accelerated Solvent Extraction, a variation of a water-isopropanol extraction method developed at the USGS National Water Quality Laboratory in Denver, CO is being employed. The concentrations of target compounds in water-isopropanol extraction fluids are subsequently analyzed using an automated Solid Phase Extraction (SPE)-GC/MS method developed in our laboratory. The coupled approaches for dewatering, extraction, and target compound identification-quantitation provide a useful alternative to enhance sample throughput for Me

Life support technology investment strategies for flight programs: An application of decision analysis

NASA Technical Reports Server (NTRS)

Schlater, Nelson J.; Simonds, Charles H.; Ballin, Mark G.

1993-01-01

Applied research and technology development (R&TD) is often characterized by uncertainty, risk, and significant delays before tangible returns are obtained. Given the increased awareness of limitations in resources, effective R&TD today needs a method for up-front assessment of competing technologies to help guide technology investment decisions. Such an assessment approach must account for uncertainties in system performance parameters, mission requirements and architectures, and internal and external events influencing a development program. The methodology known as decision analysis has the potential to address these issues. It was evaluated by performing a case study assessment of alternative carbon dioxide removal technologies for NASA"s proposed First Lunar Outpost program. An approach was developed that accounts for the uncertainties in each technology's cost and performance parameters as well as programmatic uncertainties such as mission architecture. Life cycle cost savings relative to a baseline, adjusted for the cost of money, was used as a figure of merit to evaluate each of the alternative carbon dioxide removal technology candidates. The methodology was found to provide a consistent decision-making strategy for the develpoment of new life support technology. The case study results provided insight that was not possible from more traditional analysis approaches.

Alternative Affinity Ligands for Immunoglobulins.

PubMed

Kruljec, Nika; Bratkovič, Tomaž

2017-08-16

The demand for recombinant therapeutic antibodies and Fc-fusion proteins is expected to increase in the years to come. Hence, extensive efforts are concentrated on improving the downstream processing. In particular, the development of better-affinity chromatography matrices, supporting robust time- and cost-effective antibody purification, is warranted. With the advances in molecular design and high-throughput screening approaches from chemical and biological combinatorial libraries, novel affinity ligands representing alternatives to bacterial immunoglobulin (Ig)-binding proteins have entered the scene. Here, we review the design, development, and properties of diverse classes of alternative antibody-binding ligands, ranging from engineered versions of Ig-binding proteins, to artificial binding proteins, peptides, aptamers, and synthetic small-molecular-weight compounds. We also provide examples of applications for the novel affinity matrices in chromatography and beyond.

CAPABILITIES AND SKILLS*

PubMed Central

Heckman, James J.; Corbin, Chase O.

2016-01-01

This paper discusses the relevance of recent research on the economics of human development to the work of the Human Development and Capability Association. The recent economics of human development brings insights about the dynamics of skill accumulation to an otherwise static literature on capabilities. Skills embodied in agents empower people. Enhanced skills enhance opportunities and hence promote capabilities. We address measurement problems common to both the economics of human development and the capability approach. The economics of human development analyzes the dynamics of preference formation, but is silent about which preferences should be used to evaluate alternative policies. This is both a strength and a limitation of the approach. PMID:28261378

An Alternative Methodological Approach for Cost-Effectiveness Analysis and Decision Making in Genomic Medicine.

PubMed

Fragoulakis, Vasilios; Mitropoulou, Christina; van Schaik, Ron H; Maniadakis, Nikolaos; Patrinos, George P

2016-05-01

Genomic Medicine aims to improve therapeutic interventions and diagnostics, the quality of life of patients, but also to rationalize healthcare costs. To reach this goal, careful assessment and identification of evidence gaps for public health genomics priorities are required so that a more efficient healthcare environment is created. Here, we propose a public health genomics-driven approach to adjust the classical healthcare decision making process with an alternative methodological approach of cost-effectiveness analysis, which is particularly helpful for genomic medicine interventions. By combining classical cost-effectiveness analysis with budget constraints, social preferences, and patient ethics, we demonstrate the application of this model, the Genome Economics Model (GEM), based on a previously reported genome-guided intervention from a developing country environment. The model and the attendant rationale provide a practical guide by which all major healthcare stakeholders could ensure the sustainability of funding for genome-guided interventions, their adoption and coverage by health insurance funds, and prioritization of Genomic Medicine research, development, and innovation, given the restriction of budgets, particularly in developing countries and low-income healthcare settings in developed countries. The implications of the GEM for the policy makers interested in Genomic Medicine and new health technology and innovation assessment are also discussed.

Variations in Acculturation and Australian Physical Education Teacher Education Students' Receptiveness to an Alternative Pedagogical Approach to Games Teaching

ERIC Educational Resources Information Center

Moy, Brendan; Renshaw, Ian; Davids, Keith

2014-01-01

Background: The development of intelligent, thinking performers as a central theme in physical education curriculum documents worldwide has highlighted the need for an evolution of teaching styles from the dominant reproductive approach. This has prompted an Australian university to change the content and delivery of a games unit within their…

Teaching the Societal Dimension of Chemistry Using a Socio-Critical and Problem-Oriented Lesson Plan Based on Bioethanol Usage

ERIC Educational Resources Information Center

Feierabend, Timo; Eilks, Ingo

2011-01-01

This paper discusses a chemistry lesson plan based on the use of ethanol as an alternative and renewable energy source. The lessons were developed by participatory action research and follow a socio-critical and problem-oriented approach to chemistry teaching. This approach specifically focuses on the handling of scientific and technological…

Listen-Identify-Brainstorm-Reality-Test-Encourage (LIBRE) Problem-Solving Model: Addressing Special Education Teacher Attrition through a Cognitive-Behavioral Approach to Teacher Induction

ERIC Educational Resources Information Center

Guerra, Norma S.; Hernandez, Art; Hector, Alison M.; Crosby, Shane

2015-01-01

Special education teacher attrition rates continue to challenge the profession. A cognitive-behavioral problem-solving approach was used to examine three alternative certification program special education teachers' professional development through a series of 41 interviews conducted over a 2-year period. Beginning when they were novice special…

Alternative Theoretical Bases for the Study of Human Communication: The Systems Perspective.

ERIC Educational Resources Information Center

Monge, Peter R.

Three potentially useful perspectives for the scientific development of human communication theory are the law model, the systems approach, and the rules paradigm. It is the purpose of this paper to indicate the utility of the systems approach. The first section of this paper provides a brief account of the systems view of the world. Outlined in…

Community Learning Approach (CLA) for Literacy Promotion of Women in the Fishing Villages of Region I (Philippines).

ERIC Educational Resources Information Center

Manlongat, Sylvia

After an analysis of 1990 Philippines National Statistics Office data showed a high incidence of illiteracy among women in the fishing villages, a project, Community Learning Approach (CLA), was developed to raise the literacy level. It was designed as an alternative delivery system of educating women in 24 villages for functional literacy and…

A Partnership Model for Evaluation: Considering an Alternate Approach to the Internal-External Evaluation Debate

ERIC Educational Resources Information Center

Le Menestrel, Suzanne M.; Walahoski, Jill S.; Mielke, Monica B.

2014-01-01

The 4-H youth development organization is a complex public--private partnership between the U.S. Department of Agriculture's National Institute of Food and Agriculture, the nation's Cooperative Extension system and National 4-H Council, a private, nonprofit partner. The current article is focused on a partnership approach to the…

An evidential reasoning-based AHP approach for the selection of environmentally-friendly designs

DOE Office of Scientific and Technical Information (OSTI.GOV)

NG, C.Y., E-mail: ng.cy@cityu.edu.hk

Due to the stringent environmental regulatory requirements being imposed by cross-national bodies in recent years, manufacturers have to minimize the environmental impact of their products. Among those environmental impact evaluation tools available, Life Cycle Assessment (LCA) is often employed to quantify the product's environmental impact throughout its entire life cycle. However, owing to the requirements of expert knowledge in environmental science and vast effort for data collection in carrying out LCA, as well as the common absence of complete product information during product development processes, there is a need to develop a more suitable tool for product designers. An evidentialmore » reasoning-based approach, which aims at providing a fast-track method to perform design alternative evaluations for non-LCA experts, is therefore introduced as a new initiative to deal with the incomplete or uncertain information. The proposed approach also enables decision makers to quantitatively assess the life cycle phases and design alternatives by comparing their potential environmental impacts, thus effectively and efficiently facilitates the identification of greener designs. A case application is carried out to demonstrate the applicability of the proposed approach.« less

A Rule Based Approach to ISS Interior Volume Control and Layout

NASA Technical Reports Server (NTRS)

Peacock, Brian; Maida, Jim; Fitts, David; Dory, Jonathan

2001-01-01

Traditional human factors design involves the development of human factors requirements based on a desire to accommodate a certain percentage of the intended user population. As the product is developed human factors evaluation involves comparison between the resulting design and the specifications. Sometimes performance metrics are involved that allow leniency in the design requirements given that the human performance result is satisfactory. Clearly such approaches may work but they give rise to uncertainty and negotiation. An alternative approach is to adopt human factors design rules that articulate a range of each design continuum over which there are varying outcome expectations and interactions with other variables, including time. These rules are based on a consensus of human factors specialists, designers, managers and customers. The International Space Station faces exactly this challenge in interior volume control, which is based on anthropometric, performance and subjective preference criteria. This paper describes the traditional approach and then proposes a rule-based alternative. The proposed rules involve spatial, temporal and importance dimensions. If successful this rule-based concept could be applied to many traditional human factors design variables and could lead to a more effective and efficient contribution of human factors input to the design process.

Quality metrics in high-dimensional data visualization: an overview and systematization.

PubMed

Bertini, Enrico; Tatu, Andrada; Keim, Daniel

2011-12-01

In this paper, we present a systematization of techniques that use quality metrics to help in the visual exploration of meaningful patterns in high-dimensional data. In a number of recent papers, different quality metrics are proposed to automate the demanding search through large spaces of alternative visualizations (e.g., alternative projections or ordering), allowing the user to concentrate on the most promising visualizations suggested by the quality metrics. Over the last decade, this approach has witnessed a remarkable development but few reflections exist on how these methods are related to each other and how the approach can be developed further. For this purpose, we provide an overview of approaches that use quality metrics in high-dimensional data visualization and propose a systematization based on a thorough literature review. We carefully analyze the papers and derive a set of factors for discriminating the quality metrics, visualization techniques, and the process itself. The process is described through a reworked version of the well-known information visualization pipeline. We demonstrate the usefulness of our model by applying it to several existing approaches that use quality metrics, and we provide reflections on implications of our model for future research. © 2010 IEEE

Browser App Approach: Can It Be an Answer to the Challenges in Cross-Platform App Development?

ERIC Educational Resources Information Center

Huynh, Minh; Ghimire, Prashant

2017-01-01

Aim/Purpose: As smartphones proliferate, many different platforms begin to emerge. The challenge to developers as well as IS [Information Systems] educators and students is how to learn the skills to design and develop apps to run on cross-platforms. Background: For developers, the purpose of this paper is to describe an alternative to the complex…

An integrated approach to evaluating alternative risk prediction strategies: a case study comparing alternative approaches for preventing invasive fungal disease.

PubMed

Sadique, Z; Grieve, R; Harrison, D A; Jit, M; Allen, E; Rowan, K M

2013-12-01

This article proposes an integrated approach to the development, validation, and evaluation of new risk prediction models illustrated with the Fungal Infection Risk Evaluation study, which developed risk models to identify non-neutropenic, critically ill adult patients at high risk of invasive fungal disease (IFD). Our decision-analytical model compared alternative strategies for preventing IFD at up to three clinical decision time points (critical care admission, after 24 hours, and end of day 3), followed with antifungal prophylaxis for those judged "high" risk versus "no formal risk assessment." We developed prognostic models to predict the risk of IFD before critical care unit discharge, with data from 35,455 admissions to 70 UK adult, critical care units, and validated the models externally. The decision model was populated with positive predictive values and negative predictive values from the best-fitting risk models. We projected lifetime cost-effectiveness and expected value of partial perfect information for groups of parameters. The risk prediction models performed well in internal and external validation. Risk assessment and prophylaxis at the end of day 3 was the most cost-effective strategy at the 2% and 1% risk threshold. Risk assessment at each time point was the most cost-effective strategy at a 0.5% risk threshold. Expected values of partial perfect information were high for positive predictive values or negative predictive values (£11 million-£13 million) and quality-adjusted life-years (£11 million). It is cost-effective to formally assess the risk of IFD for non-neutropenic, critically ill adult patients. This integrated approach to developing and evaluating risk models is useful for informing clinical practice and future research investment. © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Published by International Society for Pharmacoeconomics and Outcomes Research (ISPOR) All rights reserved.

How I Teach the Second Law of Thermodynamics

ERIC Educational Resources Information Center

Kincanon, Eric

2013-01-01

An alternative method of presenting the second law of thermodynamics in introductory courses is presented. The emphasis is on statistical approaches as developed by Atkins. This has the benefit of stressing the statistical nature of the law.

Portfolio Assessment of Multicultural Counseling Competency.

ERIC Educational Resources Information Center

Coleman, Hardin L. K.

1996-01-01

Presents portfolio assessment as an alternate approach to the measurement of multicultural counseling competency, and evaluates the strengths and weaknesses of portfolio assessment. Identifies the effectiveness of portfolio assessment in stimulating the development of further counseling competence. (SNR)

Final report for “Extreme-scale Algorithms and Solver Resilience”

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gropp, William Douglas

2017-06-30

This is a joint project with principal investigators at Oak Ridge National Laboratory, Sandia National Laboratories, the University of California at Berkeley, and the University of Tennessee. Our part of the project involves developing performance models for highly scalable algorithms and the development of latency tolerant iterative methods. During this project, we extended our performance models for the Multigrid method for solving large systems of linear equations and conducted experiments with highly scalable variants of conjugate gradient methods that avoid blocking synchronization. In addition, we worked with the other members of the project on alternative techniques for resilience and reproducibility.more » We also presented an alternative approach for reproducible dot-products in parallel computations that performs almost as well as the conventional approach by separating the order of computation from the details of the decomposition of vectors across the processes.« less

An approach to quantitative sustainability assessment in the early stages of process design.

PubMed

Tugnoli, Alessandro; Santarelli, Francesco; Cozzani, Valerio

2008-06-15

A procedure was developed for the quantitative assessment of key performance indicators suitable for the sustainability analysis of alternative processes, mainly addressing the early stages of process design. The methodology was based on the calculation of a set of normalized impact indices allowing a direct comparison of the additional burden of each process alternative on a selected reference area. Innovative reference criteria were developed to compare and aggregate the impact indicators on the basis of the site-specific impact burden and sustainability policy. An aggregation procedure also allows the calculation of overall sustainability performance indicators and of an "impact fingerprint" of each process alternative. The final aim of the method is to support the decision making process during process development, providing a straightforward assessment of the expected sustainability performances. The application of the methodology to case studies concerning alternative waste disposal processes allowed a preliminary screening of the expected critical sustainability impacts of each process. The methodology was shown to provide useful results to address sustainability issues in the early stages of process design.

Development of a Synergistic Case-Based Micro anatomy Curriculum

ERIC Educational Resources Information Center

McBride, Jennifer M.; Prayson, Richard A.

2008-01-01

This paper discusses the development of an interactive approach to teaching and assessing a micro anatomy curriculum in an innovative medical school program. As an alternative to lectures and labs, students are engaged in interactive seminars focused on discussion of clinical and research-based cases matched with normal histology and pathology…

The National Assessment Approach to Objectives and Exercise Development.

ERIC Educational Resources Information Center

Ward, Barbara

The National Assessment of Educational Progress (NAEP) item development procedures, possible improvements or alternatives to these procedures, and methods used to control potential sources of errors of interpretation are described. Current procedures call for the assessment of 9-, 13- and 17-year-olds in subject areas typically taught in schools.…

Applying Problem Solving to Statistics and Consumer Mathematics.

ERIC Educational Resources Information Center

Hawaii Univ., Honolulu. Curriculum Research and Development Group.

This text is an example of a Selected Mathematics Applications (Level A) course, developed for the Hawaii State Department of Education. There are two basic parts to this document. Section one discusses the approach used to develop this course, and provides a brief description of current alternative materials and resources. No materials were found…

Developing Critical Education Thought in Community Development: The Freirean Approach in Japan

ERIC Educational Resources Information Center

Miyazaki, Takashi

2017-01-01

If we use words from Freirean thought, we can find "indigenous Freirean thought" in each country. This paper discussed critical education theory's maturing process during Japan's modernization process and analyzed the conditions for creating an alternative community, based on an emancipatory learning practice. In East Asian countries,…

Development of an acute oral toxicity dataset to facilitate assessment of existing QSARs and development of new models (WC10)

EPA Science Inventory

Acute oral toxicity data are used to meet both regulatory and non-regulatory needs. Recently, there have been efforts to explore alternative approaches for predicting acute oral toxicity such as QSARs. Evaluating the performance and scope of existing models and investigating the ...

Today's Action Tomorrow's Profit. An Alternative Approach to Community Development.

ERIC Educational Resources Information Center

Burnell, Elaine H., Ed.

During May 1972, the Adult Education Center of Santa Barbara City College sponsored a symposium on the goals and purposes of planning for community development. Through lecture and discussion, members of the community undertook a critical review of the related problems of community, growth, population, taxes, transportation, zoning and water. This…

An Alternative Approach to Identifying a Dimension in Second Language Proficiency.

ERIC Educational Resources Information Center

Griffin, Patrick E.; And Others

Current practice in language testing has not yet integrated classical test theory with assessment of language skills. In addition, language testing needs to be part of theory development. Lack of sound testing procedures can lead to problems in research design and ultimately, inappropriate theory development. The debate over dimensionality of…

Strengths, Opportunities, Aspirations, and Results: An Emerging Approach to Organization Development

ERIC Educational Resources Information Center

Zarestky, Jill; Cole, Catherine S.

2017-01-01

Organization development (OD) interventions have typically relied on the strengths, weaknesses, opportunities, and threats (SWOT) framework for strategic planning. The strengths, opportunities, aspirations, and results (SOAR) framework is a relatively new innovation in OD that may serve as a viable alternative to SWOT for those who wish to apply…

The Abstraction-First Approach to Data Abstraction and Algorithms.

ERIC Educational Resources Information Center

Machanick, Philip

1998-01-01

Based on a computer-science course, this article outlines an alternative ordering of programming concepts that aims to develop a reuse habit before other styles of programming are developed. Although the discussion is based on transition from Modula-2 to C++, the issues raised apply to transition from any procedural to any object-oriented…

An Employment Service Research and Development Strategy.

ERIC Educational Resources Information Center

Aller, Curtis C.; And Others

The report presents a strategy developed by an outside research group for the manpower administration which would: (1) identify and organize the questions facing the U.S. Employment Service (ES), (2) set priorities among the questions, and (3) outline alternative approaches for answering the questions. The study was undertaken in order to clarify…

Education and the State: Federal Involvement in Educational Policy Development. Policy Development and Analysis Series.

ERIC Educational Resources Information Center

White, Doug

This volume is part of a series of monographs from Australia devoted to outlining an alternative approach, based on neo-Marxist concepts, to policy studies in education. The opening essay in this volume is a historical analysis of federal involvement in Australian educational policy development. After a descriptive overview of the role of…

The Development of Science Student Worksheet Based on Education for Environmental Sustainable Development to Enhance Scientific Literacy

ERIC Educational Resources Information Center

Ekantini, Anita; Wilujeng, Insih

2018-01-01

Indonesia is a country that has abundant renewable energy sources, one of which is hydropower that can be utilized as an alternative energy source. However, fossil energy remains as major supplier of energy needs in all sectors of activity. The Education for Environmental Sustainable Development (EESD) approach can be applied in science education…

Scripting MODFLOW Model Development Using Python and FloPy.

PubMed

Bakker, M; Post, V; Langevin, C D; Hughes, J D; White, J T; Starn, J J; Fienen, M N

2016-09-01

Graphical user interfaces (GUIs) are commonly used to construct and postprocess numerical groundwater flow and transport models. Scripting model development with the programming language Python is presented here as an alternative approach. One advantage of Python is that there are many packages available to facilitate the model development process, including packages for plotting, array manipulation, optimization, and data analysis. For MODFLOW-based models, the FloPy package was developed by the authors to construct model input files, run the model, and read and plot simulation results. Use of Python with the available scientific packages and FloPy facilitates data exploration, alternative model evaluations, and model analyses that can be difficult to perform with GUIs. Furthermore, Python scripts are a complete, transparent, and repeatable record of the modeling process. The approach is introduced with a simple FloPy example to create and postprocess a MODFLOW model. A more complicated capture-fraction analysis with a real-world model is presented to demonstrate the types of analyses that can be performed using Python and FloPy. © 2016, National Ground Water Association.

Development and Deployment of Systems-Based Approaches for the Management of Soilborne Plant Pathogens.

PubMed

Chellemi, D O; Gamliel, A; Katan, J; Subbarao, K V

2016-03-01

Biological suppression of soilborne diseases with minimal use of outside interventive actions has been difficult to achieve in high input conventional crop production systems due to the inherent risk of pest resurgence. This review examines previous approaches to the management of soilborne disease as precursors to the evolution of a systems-based approach, in which plant disease suppression through natural biological feedback mechanisms in soil is incorporated into the design and operation of cropping systems. Two case studies are provided as examples in which a systems-based approach is being developed and deployed in the production of high value crops: lettuce/strawberry production in the coastal valleys of central California (United States) and sweet basil and other herb crop production in Israel. Considerations for developing and deploying system-based approaches are discussed and operational frameworks and metrics to guide their development are presented with the goal of offering a credible alternative to conventional approaches to soilborne disease management.

40 CFR Appendix A to Subpart Kk of... - Data Quality Objective and Lower Confidence Limit Approaches for Alternative Capture Efficiency...

Code of Federal Regulations, 2013 CFR

2013-07-01

... approach follows: 4.3A source conducts an initial series of at least three runs. The owner or operator may... Confidence Limit Approaches for Alternative Capture Efficiency Protocols and Test Methods A Appendix A to... to Subpart KK of Part 63—Data Quality Objective and Lower Confidence Limit Approaches for Alternative...

40 CFR Appendix A to Subpart Kk of... - Data Quality Objective and Lower Confidence Limit Approaches for Alternative Capture Efficiency...

Code of Federal Regulations, 2010 CFR

2010-07-01

... approach follows: 4.3A source conducts an initial series of at least three runs. The owner or operator may... Confidence Limit Approaches for Alternative Capture Efficiency Protocols and Test Methods A Appendix A to... to Subpart KK of Part 63—Data Quality Objective and Lower Confidence Limit Approaches for Alternative...

40 CFR Appendix A to Subpart Kk of... - Data Quality Objective and Lower Confidence Limit Approaches for Alternative Capture Efficiency...

Code of Federal Regulations, 2014 CFR

2014-07-01

... of the LCL approach follows: 4.3A source conducts an initial series of at least three runs. The owner... Confidence Limit Approaches for Alternative Capture Efficiency Protocols and Test Methods A Appendix A to... to Subpart KK of Part 63—Data Quality Objective and Lower Confidence Limit Approaches for Alternative...

40 CFR Appendix A to Subpart Kk of... - Data Quality Objective and Lower Confidence Limit Approaches for Alternative Capture Efficiency...

Code of Federal Regulations, 2012 CFR

2012-07-01

... approach follows: 4.3A source conducts an initial series of at least three runs. The owner or operator may... Confidence Limit Approaches for Alternative Capture Efficiency Protocols and Test Methods A Appendix A to... to Subpart KK of Part 63—Data Quality Objective and Lower Confidence Limit Approaches for Alternative...

Bayesian Factor Analysis as a Variable Selection Problem: Alternative Priors and Consequences

PubMed Central

Lu, Zhao-Hua; Chow, Sy-Miin; Loken, Eric

2016-01-01

Factor analysis is a popular statistical technique for multivariate data analysis. Developments in the structural equation modeling framework have enabled the use of hybrid confirmatory/exploratory approaches in which factor loading structures can be explored relatively flexibly within a confirmatory factor analysis (CFA) framework. Recently, a Bayesian structural equation modeling (BSEM) approach (Muthén & Asparouhov, 2012) has been proposed as a way to explore the presence of cross-loadings in CFA models. We show that the issue of determining factor loading patterns may be formulated as a Bayesian variable selection problem in which Muthén and Asparouhov’s approach can be regarded as a BSEM approach with ridge regression prior (BSEM-RP). We propose another Bayesian approach, denoted herein as the Bayesian structural equation modeling with spike and slab prior (BSEM-SSP), which serves as a one-stage alternative to the BSEM-RP. We review the theoretical advantages and disadvantages of both approaches and compare their empirical performance relative to two modification indices-based approaches and exploratory factor analysis with target rotation. A teacher stress scale data set (Byrne, 2012; Pettegrew & Wolf, 1982) is used to demonstrate our approach. PMID:27314566

Alternative approaches for better municipal solid waste management in Mumbai, India

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rathi, Sarika

2006-07-01

Waste is an unavoidable by product of human activities. Economic development, urbanization and improving living standards in cities, have led to an increase in the quantity and complexity of generated waste. Rapid growth of population and industrialization degrades the urban environment and places serious stress on natural resources, which undermines equitable and sustainable development. Inefficient management and disposal of solid waste is an obvious cause of degradation of the environment in most cities of the developing world. Municipal corporations of the developing countries are not able to handle increasing quantities of waste, which results in uncollected waste on roads andmore » in other public places. There is a need to work towards a sustainable waste management system, which requires environmental, institutional, financial, economic and social sustainability. This study explores alternative approaches to municipal solid waste (MSW) management and estimates the cost of waste management in Mumbai, India. Two alternatives considered in the paper are community participation and public private partnership in waste management. Data for the present study are from various non-governmental organizations (NGOs) and from the private sector involved in waste management in Mumbai. Mathematical models are used to estimate the cost per ton of waste management for both of the alternatives, which are compared with the cost of waste management by Municipal Corporation of Greater Mumbai (MCGM). It is found that the cost per ton of waste management is Rs. 1518 (US$35) with community participation; Rs. 1797 (US$41) with public private partnership (PPP); and Rs. 1908 (US$44) when only MCGM handles the waste. Hence, community participation in waste management is the least cost option and there is a strong case for comprehensively involving community participation in waste management.« less

An alternative approach for socio-hydrology: case study research

NASA Astrophysics Data System (ADS)

Mostert, Erik

2018-01-01

Currently the most popular approach in socio hydrology is to develop coupled human-water models. This article proposes an alternative approach, qualitative case study research, involving a systematic review of (1) the human activities affecting the hydrology in the case, (2) the main human actors, and (3) the main factors influencing the actors and their activities. Moreover, this article presents a case study of the Dommel Basin in Belgium and the Netherlands, and compares this with a coupled model of the Kissimmee Basin in Florida. In both basins a pendulum swing from water resources development and control to protection and restoration can be observed. The Dommel case study moreover points to the importance of institutional and financial arrangements, community values, and broader social, economic, and technical developments. These factors are missing from the Kissimmee model. Generally, case studies can result in a more complete understanding of individual cases than coupled models, and if the cases are selected carefully and compared with previous studies, it is possible to generalize on the basis of them. Case studies also offer more levers for management and facilitate interdisciplinary cooperation. Coupled models, on the other hand, can be used to generate possible explanations of past developments and quantitative scenarios for future developments. The article concludes that, given the limited attention they currently get and their potential benefits, case studies deserve more attention in socio-hydrology.

Proceedings of the Symposium on Current Concepts and Approaches on Animal Test Alternatives

DTIC Science & Technology

1993-09-01

vertebrate model, more specifically, the chorloallantoic membrane (CAN) of a developing chicken embryo, has been proposed for use as an alternative...and Drug Administration in Washington, D.C. He has a B.S. in pharmacy (University of New Mexico ) and a Ph.D. in pharmacology (University of Colorado...model is represented by the choriallantoic membrane system (CAM).20,21 This system uses fertilized chicken eggs, whose vascular network (or CAM) is

Green Toxicology-Know Early About and Avoid Toxic Product Liabilities.

PubMed

Maertens, Alexandra; Hartung, Thomas

2018-02-01

Toxicology uniquely among the life sciences relies largely on methods which are more than 40-years old. Over the last 3 decades with more or less success some additions to and few replacements in this toolbox took place, mainly as alternatives to animal testing. The acceptance of such new approaches faces the needs of formal validation and the conservative attitude toward change in safety assessments. Only recently, there is growing awareness that the same alternative methods, especially in silico and in vitro tools can also much earlier and before validation inform decision-taking in the product life cycle. As similar thoughts developed in the context of Green Chemistry, the term of Green Toxicology was coined to describe this change in approach. Here, the current developments in the alternative field, especially computational and more organo-typic cell cultures are reviewed, as they lend themselves to front-loaded chemical safety assessments. The initiatives of the Center for Alternatives to Animal Testing Green Toxicology Collaboration are presented. They aim first of all for forming a community to promote this concept and then for a cultural change in companies with the necessary training of chemists, product stewards and later regulators. © The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Hunters' acceptability of the surveillance system and alternative surveillance strategies for classical swine fever in wild boar - a participatory approach.

PubMed

Schulz, Katja; Calba, Clémentine; Peyre, Marisa; Staubach, Christoph; Conraths, Franz J

2016-09-06

Surveillance measures can only be effective if key players in the system accept them. Acceptability, which describes the willingness of persons to contribute, is often analyzed using participatory methods. Participatory epidemiology enables the active involvement of key players in the assessment of epidemiological issues. In the present study, we used a participatory method recently developed by CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement) to evaluate the functionality and acceptability of Classical Swine Fever (CSF) surveillance in wild boar in Germany, which is highly dependent on the participation of hunters. The acceptability of alternative surveillance strategies was also analyzed. By conducting focus group discussions, potential vulnerabilities in the system were detected and feasible alternative surveillance strategies identified. Trust in the current surveillance system is high, whereas the acceptability of the operation of the system is medium. Analysis of the acceptability of alternative surveillance strategies showed how risk-based surveillance approaches can be combined to develop strategies that have sufficient support and functionality. Furthermore, some surveillance strategies were clearly rejected by the hunters. Thus, the implementation of such strategies may be difficult. Participatory methods can be used to evaluate the functionality and acceptability of existing surveillance plans for CSF among hunters and to optimize plans regarding their chances of successful implementation.

Alternative methods for the control of postharvest citrus diseases.

PubMed

Talibi, I; Boubaker, H; Boudyach, E H; Ait Ben Aoumar, A

2014-07-01

The postharvest diseases of citrus fruit cause considerable losses during storage and transportation. These diseases are managed principally by the application of synthetic fungicides. However, the increasing concern for health hazards and environmental pollution due to chemical use has required the development of alternative strategies for the control of postharvest citrus diseases. Management of postharvest diseases using microbial antagonists, natural plant-derived products and Generally Recognized As Safe compounds has been demonstrated to be most suitable to replace the synthetic fungicides, which are either being banned or recommended for limited use. However, application of these alternatives by themselves may not always provide a commercially acceptable level of control of postharvest citrus diseases comparable to that obtained with synthetic fungicides. To provide more effective disease control, a multifaceted approach based on the combination of different postharvest treatments has been adopted. Actually, despite the distinctive features of these alternative methods, several reasons hinder the commercial use of such treatments. Consequently, research should emphasize the development of appropriate tools to effectively implement these alternative methods to commercial citrus production. © 2014 The Society for Applied Microbiology.

Reference Mission Version 3.0 Addendum to the Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team. Addendum; 3.0

NASA Technical Reports Server (NTRS)

Drake, Bret G. (Editor)

1998-01-01

This Addendum to the Mars Reference Mission was developed as a companion document to the NASA Special Publication 6107, "Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team." It summarizes changes and updates to the Mars Reference Missions that were developed by the Exploration Office since the final draft of SP 6107 was printed in early 1999. The Reference Mission is a tool used by the exploration community to compare and evaluate approaches to mission and system concepts that could be used for human missions to Mars. It is intended to identify and clarify system drivers, significant sources of cost, performance, risk, and schedule variation. Several alternative scenarios, employing different technical approaches to solving mission and technology challenges, are discussed in this Addendum. Comparing alternative approaches provides the basis for continual improvement to technology investment plan and a general understanding of future human missions to Mars. The Addendum represents a snapshot of work in progress in support of planning for future human exploration missions through May 1998.

Alternative Energy Science and Policy: Biofuels as a Case Study

NASA Astrophysics Data System (ADS)

Ammous, Saifedean H.

This dissertation studies the science and policy-making of alternative energy using biofuels as a case study, primarily examining the instruments that can be used to alleviate the impacts of climate change and their relative efficacy. Three case studies of policy-making on biofuels in the European Union, United States of America and Brazil are presented and discussed. It is found that these policies have had large unintended negative consequences and that they relied on Lifecycle Analysis studies that had concluded that increased biofuels production can help meet economic, energy and environmental goals. A close examination of these Lifecycle Analysis studies reveals that their results are not conclusive. Instead of continuing to attempt to find answers from Lifecycle Analyses, this study suggests an alternative approach: formulating policy based on recognition of the ignorance of real fuel costs and pollution. Policies to combat climate change are classified into two distinct approaches: policies that place controls on the fuels responsible for emissions and policies that target the pollutants themselves. A mathematical model is constructed to compare these two approaches and address the central question of this study: In light of an ignorance of the cost and pollution impacts of different fuels, are policies targeting the pollutants themselves preferable to policies targeting the fuels? It is concluded that in situations where the cost and pollution functions of a fuel are unknown, subsidies, mandates and caps on the fuel might result in increased or decreased greenhouse gas emissions; on the other hand, a tax or cap on carbon dioxide results in the largest decrease possible of greenhouse gas emissions. Further, controls on greenhouse gases are shown to provide incentives for the development and advancement of cleaner alternative energy options, whereas controls on the fuels are shown to provide equal incentives to the development of cleaner and dirtier alternative fuels. This asymmetry in outcomes---regardless of actual cost functions---is the reason why controls on greenhouse gases are deemed favorable to direct fuel subsidies and mandates.

Structured decision making for managing pneumonia epizootics in bighorn sheep

USGS Publications Warehouse

Sells, Sarah N.; Mitchell, Michael S.; Edwards, Victoria L.; Gude, Justin A.; Anderson, Neil J.

2016-01-01

Good decision-making is essential to conserving wildlife populations. Although there may be multiple ways to address a problem, perfect solutions rarely exist. Managers are therefore tasked with identifying decisions that will best achieve desired outcomes. Structured decision making (SDM) is a method of decision analysis used to identify the most effective, efficient, and realistic decisions while accounting for values and priorities of the decision maker. The stepwise process includes identifying the management problem, defining objectives for solving the problem, developing alternative approaches to achieve the objectives, and formally evaluating which alternative is most likely to accomplish the objectives. The SDM process can be more effective than informal decision-making because it provides a transparent way to quantitatively evaluate decisions for addressing multiple management objectives while incorporating science, uncertainty, and risk tolerance. To illustrate the application of this process to a management need, we present an SDM-based decision tool developed to identify optimal decisions for proactively managing risk of pneumonia epizootics in bighorn sheep (Ovis canadensis) in Montana. Pneumonia epizootics are a major challenge for managers due to long-term impacts to herds, epistemic uncertainty in timing and location of future epizootics, and consequent difficulty knowing how or when to manage risk. The decision tool facilitates analysis of alternative decisions for how to manage herds based on predictions from a risk model, herd-specific objectives, and predicted costs and benefits of each alternative. Decision analyses for 2 example herds revealed that meeting management objectives necessitates specific approaches unique to each herd. The analyses showed how and under what circumstances the alternatives are optimal compared to other approaches and current management. Managers can be confident that these decisions are effective, efficient, and realistic because they explicitly account for important considerations managers implicitly weigh when making decisions, including competing management objectives, uncertainty in potential outcomes, and risk tolerance.

Divorce Mediation and Its Emotional Impact on the Couple and Their Children.

ERIC Educational Resources Information Center

Kaslow, Florence W.

1984-01-01

Discusses the influence of development on divorce, and presents a diaclectic model of divorce stages. Suggests mediation as an alternative dispute resolution strategy and describes contraindications for both mediation and the adversarial approach. (JAC)

Analyzing trade-offs between fuels management, suppression, and damages from wildfire

Treesearch

D. Evan Mercer; Robert G. Haight; Jeffrey P. Prestemon

2008-01-01

With expenditures to suppress wildfires in the United States increasing rapidly during the past couple of decades, fire managers, scientists, and policy makers have begun an intense effort to develop alternative approaches to managing wildfire.

Alternative approaches to condition monitoring in freeway management systems.

DOT National Transportation Integrated Search

2002-01-01

In response to growing concerns over traffic congestion, traffic management systems have been built in large urban areas in an effort to improve the efficiency and safety of the transportation network. This research effort developed an automated cond...

HEAVY METALS STRUCTURE BENTHIC COMUNITIES IN COLORADO MOUNTAIN STREAMS

EPA Science Inventory

The development of field sampling designs that employ multiple reference and polluted sites has been proposed as an alternative to the traditional upstream vs. downstream approach used in most biomonitoring studies. Spatially extensive monitoring programs can characterize ecologi...

Potential preventive strategies and therapies in urinary tract infection.

PubMed

Reid, G

1999-12-01

There are perhaps five strategies either presently advocated or under investigation for prevention of recurrent urinary tract infection (UTI): antibiotics, including natural peptides; functional foods; vaccines; probiotics; and miscellaneous, including avoidance of spermicides and maintenance of good hygiene. It is not possible to state the proportion of patients using antibiotics versus foods such as cranberry or using alternative approaches such as avoidance of spermicides. The majority of women who are referred to specialists will be prescribed long-term, low-dose antibiotics. However, given the magnitude of the problem, it is safe to state that large numbers of women are at least experimenting with alternative remedies such as drinking of cranberry juice or ingestion of herbal remedies with a view to enhancing their immune response. Vaccine development remains a long way from human use and has yet to be developed for organisms other than Escherichia coli. The use of probiotics of restore the normal vaginal flora and provide a competitive bacterial barrier to pathogens is close to becoming available as an alternative preventive approach. The next decade should see the introduction of new methods for reduction of the high incidence of UTI and better management of recurring urogenital infections.

Collaborative deliberation: a model for patient care.

PubMed

Elwyn, Glyn; Lloyd, Amy; May, Carl; van der Weijden, Trudy; Stiggelbout, Anne; Edwards, Adrian; Frosch, Dominick L; Rapley, Tim; Barr, Paul; Walsh, Thom; Grande, Stuart W; Montori, Victor; Epstein, Ronald

2014-11-01

Existing theoretical work in decision making and behavior change has focused on how individuals arrive at decisions or form intentions. Less attention has been given to theorizing the requirements that might be necessary for individuals to work collaboratively to address difficult decisions, consider new alternatives, or change behaviors. The goal of this work was to develop, as a forerunner to a middle range theory, a conceptual model that considers the process of supporting patients to consider alternative health care options, in collaboration with clinicians, and others. Theory building among researchers with experience and expertise in clinician-patient communication, using an iterative cycle of discussions. We developed a model composed of five inter-related propositions that serve as a foundation for clinical communication processes that honor the ethical principles of respecting individual agency, autonomy, and an empathic approach to practice. We named the model 'collaborative deliberation.' The propositions describe: (1) constructive interpersonal engagement, (2) recognition of alternative actions, (3) comparative learning, (4) preference construction and elicitation, and (5) preference integration. We believe the model underpins multiple suggested approaches to clinical practice that take the form of patient centered care, motivational interviewing, goal setting, action planning, and shared decision making. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review.

PubMed

Gadde, U; Kim, W H; Oh, S T; Lillehoj, Hyun S

2017-06-01

With the increase in regulations regarding the use of antibiotic growth promoters and the rise in consumer demand for poultry products from 'Raised Without Antibiotics' or 'No Antibiotics Ever' flocks, the quest for alternative products or approaches has intensified in recent years. A great deal of research has focused on the development of antibiotic alternatives to maintain or improve poultry health and performance. This review describes the potential for the various alternatives available to increase animal productivity and help poultry perform to their genetic potential under existing commercial conditions. The classes of alternatives described include probiotics, prebiotics, synbiotics, organic acids, enzymes, phytogenics, antimicrobial peptides, hyperimmune egg antibodies, bacteriophages, clay, and metals. A brief description of the mechanism of action, efficacy, and advantages and disadvantages of their uses are also presented. Though the beneficial effects of many of the alternatives developed have been well demonstrated, the general consensus is that these products lack consistency and the results vary greatly from farm to farm. Furthermore, their mode of action needs to be better defined. Optimal combinations of various alternatives coupled with good management and husbandry practices will be the key to maximize performance and maintain animal productivity, while we move forward with the ultimate goal of reducing antibiotic use in the animal industry.

Sodium Bearing Waste Processing Alternatives Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, James Anthony; Palmer, Brent J; Perry, Keith Joseph

2003-12-01

A multidisciplinary team gathered to develop a BBWI recommendation to DOE-ID on the processing alternatives for the sodium bearing waste in the INTEC Tank Farm. Numerous alternatives were analyzed using a rigorous, systematic approach. The data gathered were evaluated through internal and external peer reviews for consistency and validity. Three alternatives were identified to be top performers: Risk-based Calcination, MACT to WIPP Calcination and Cesium Ion Exchange. A dual-path through early Conceptual design is recommended for MACT to WIPP Calcination and Cesium Ion Exchange since Risk-based Calcination does not require design. If calcination alternatives are not considered based on givingmore » Type of Processing criteria significantly greater weight, the CsIX/TRUEX alternative follows CsIX in ranking. However, since CsIX/TRUEX shares common uncertainties with CsIX, reasonable backups, which follow in ranking, are the TRUEX and UNEX alternatives. Key uncertainties must be evaluated by the decision-makers to choose one final alternative. Those key uncertainties and a path forward for the technology roadmapping of these alternatives is provided.« less

Sustainable urban water systems in rich and poor cities--steps towards a new approach.

PubMed

Newman, P

2001-01-01

The 'big pipes in, big pipes out' approach to urban water management was developed in the 19th century for a particular linear urban form. Large, sprawling car-dependent cities are pushing this approach to new limits in rich cities and it has never worked in poor cities. An alternative which uses new small-scale technology and is more community-based, is suggested for both rich and poor countries. The Sydney Olympics and a demonstration project in Java show that the approach can work.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Training programs at DOE facilities should prepare personnel to safely and efficiently operate and maintain the facilities in accordance with DOE requirements. This guide presents good practices for a systematic approach to on-the-job training (OJT) and OJT programs and should be used in conjunction with DOE Training Program Handbook: A Systematic Approach to Training, and with the DOE Handbook entitled Alternative Systematic Approaches to Training to develop performance-based OJT programs. DOE contractors may also use this guide to modify existing OJT programs that do not meet the systematic approach to training (SAT) objectives.

Strength Enhancement and Application Development of Carbon Foam for Thermal Protection Systems

DTIC Science & Technology

2004-09-01

to implementation was the inherent weakness and friability of the carbon foams. Under a MDA funded SBIR program, Ceramic Composites Inc . has...there are two approaches under consideration for utilizing carbon foams. Allcomp Inc.iii, Materials and Electrochemical Researchiv, Touchstonev...Ceramic Composites Inc . (CCI) elected to take an alternative approach to enhancing the strength of carbon foam. For our evaluation, two polymeric pre

A Financial Approach as an Alternative Organizational Development Intervention.

DTIC Science & Technology

1979-12-01

Participants: (age group) (#Available) (# Program (#confirmed/ designed for) reserved) Program requested by: Board of Directors PSO Staff Community...Milestone chart approved by: on ’ name date 59 APPENDIX F PSO PROGRAM WORKSHEET INSTRUCTIONS Purpose: The Program Worksheet is designed to collect all inform...11. Grossman, Lee, The Change Agent, Amacom, New York, 1974. 12. Harvey, Donald F., and Brown, Donald R., An Eperimental Approach to Organization

Developing Distinct Mathematical and Scientific Pedagogical Content Knowledge in an Early Childhood Dual-Content Methods Course: An Alternative to Integration

ERIC Educational Resources Information Center

Kalchman, Mindy; Kozoll, Richard H.

2017-01-01

Methods for teaching early childhood mathematics and science are often addressed in a single, dual-content course. Approaches to teaching this type of course include integrating the content and the pedagogy of both subjects, or keeping the subject areas distinct. In this article, the authors discuss and illustrate their approach to such a combined…

Dynamic Approaches to Language Processing

ERIC Educational Resources Information Center

Srinivasan, Narayanan

2007-01-01

Symbolic rule-based approaches have been a preferred way to study language and cognition. Dissatisfaction with rule-based approaches in the 1980s lead to alternative approaches to study language, the most notable being the dynamic approaches to language processing. Dynamic approaches provide a significant alternative by not being rule-based and…

Satellite Power Systems (SPS) concept definition study (exhibit C)

NASA Technical Reports Server (NTRS)

Hanley, G. M.

1978-01-01

A coplanar satellite conceptual approach was defined. This effort included several trade studies related to satellite design and also construction approaches for this satellite. A transportation system, consistent with this concept, was also studied, including an electric orbit transfer vehicle and a parallel-burn heavy lift launch vehicle. Work on a solid state microwave concept continued and several alternative approaches were evaluated. Computer determination of an optimized transistor and circuit design was also continued. Experiment/verification planning resulted in the development of a total solar array and microwave technology development plan, as well as definition of near-term research to evaluate key technology issues.

Regulatory aspects on the use of fish embryos in environmental toxicology.

PubMed

Halder, Marlies; Léonard, Marc; Iguchi, Taisen; Oris, James T; Ryder, Kathy; Belanger, Scott E; Braunbeck, Thomas A; Embry, Michelle R; Whale, Graham; Norberg-King, Teresa; Lillicrap, Adam

2010-07-01

Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management of chemicals and wastewater discharges. The ILSI Health and Environmental Sciences Institute and the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) held an International Workshop on the Application of the Fish Embryo Test in March, 2008. This relatively young discipline is following advances in animal alternatives for human safety sciences, and it is advisable to develop a broad comparison of how animal alternative tests involving fish are viewed in a regulatory context over a wide array of authorities or advising bodies. These include OECD, Western Europe, North America, and Japan. This paper summarizes representative practices from these regions. Presently, the global regulatory environment has varying stances regarding the protection of fish for use as an experimental animal. Such differences have a long-term potential to lead to a lack of harmony in approaches to fish toxicity testing, especially for chemicals in commerce across multiple geographic regions. Implementation of alternative methods and approaches will be most successful if accepted globally, including methods of fish toxicity testing. An important area for harmonization would be in the interpretation of protected and nonprotected life stages of fish. Use of fish embryos represent a promising alternative and allow bridging to more technically challenging alternatives with longer prospective timelines, including cell-based assays, ecotoxicogenomics, and QSARs. (c) 2010 SETAC.

A Driving Bioinformatics Approach to Explore Co-regulation of AOX Gene Family Members During Growth and Development.

PubMed

Costa, José Hélio; Arnholdt-Schmitt, Birgit

2017-01-01

The alternative oxidase (AOX) gene family is a hot candidate for functional marker development that could help plant breeding on yield stability through more robust plants based on multi-stress tolerance. However, there is missing knowledge on the interplay between gene family members that might interfere with the efficiency of marker development. It is common view that AOX1 and AOX2 have different physiological roles. Nevertheless, both family member groups act in terms of molecular-biochemical function as "typical" alternative oxidases and co-regulation of AOX1 and AOX2 had been reported. Although conserved sequence differences had been identified, the basis for differential effects on physiology regulation is not sufficiently explored.This protocol gives instructions for a bioinformatics approach that supports discovering potential interaction of AOX family members in regulating growth and development. It further provides a strategy to elucidate the relevance of gene sequence diversity and copy number variation for final functionality in target tissues and finally the whole plant. Thus, overall this protocol provides the means for efficiently identifying plant AOX variants as functional marker candidates related to growth and development.

An Alternative Myoelectric Pattern Recognition Approach for the Control of Hand Prostheses: A Case Study of Use in Daily Life by a Dysmelia Subject

PubMed Central

Ahlberg, Johan; Lendaro, Eva; Hermansson, Liselotte; Håkansson, Bo; Ortiz-Catalan, Max

2018-01-01

The functionality of upper limb prostheses can be improved by intuitive control strategies that use bioelectric signals measured at the stump level. One such strategy is the decoding of motor volition via myoelectric pattern recognition (MPR), which has shown promising results in controlled environments and more recently in clinical practice. Moreover, not much has been reported about daily life implementation and real-time accuracy of these decoding algorithms. This paper introduces an alternative approach in which MPR allows intuitive control of four different grips and open/close in a multifunctional prosthetic hand. We conducted a clinical proof-of-concept in activities of daily life by constructing a self-contained, MPR-controlled, transradial prosthetic system provided with a novel user interface meant to log errors during real-time operation. The system was used for five days by a unilateral dysmelia subject whose hand had never developed, and who nevertheless learned to generate patterns of myoelectric activity, reported as intuitive, for multi-functional prosthetic control. The subject was instructed to manually log errors when they occurred via the user interface mounted on the prosthesis. This allowed the collection of information about prosthesis usage and real-time classification accuracy. The assessment of capacity for myoelectric control test was used to compare the proposed approach to the conventional prosthetic control approach, direct control. Regarding the MPR approach, the subject reported a more intuitive control when selecting the different grips, but also a higher uncertainty during proportional continuous movements. This paper represents an alternative to the conventional use of MPR, and this alternative may be particularly suitable for a certain type of amputee patients. Moreover, it represents a further validation of MPR with dysmelia cases. PMID:29637030

An Alternative Myoelectric Pattern Recognition Approach for the Control of Hand Prostheses: A Case Study of Use in Daily Life by a Dysmelia Subject.

PubMed

Mastinu, Enzo; Ahlberg, Johan; Lendaro, Eva; Hermansson, Liselotte; Hakansson, Bo; Ortiz-Catalan, Max

2018-01-01

The functionality of upper limb prostheses can be improved by intuitive control strategies that use bioelectric signals measured at the stump level. One such strategy is the decoding of motor volition via myoelectric pattern recognition (MPR), which has shown promising results in controlled environments and more recently in clinical practice. Moreover, not much has been reported about daily life implementation and real-time accuracy of these decoding algorithms. This paper introduces an alternative approach in which MPR allows intuitive control of four different grips and open/close in a multifunctional prosthetic hand. We conducted a clinical proof-of-concept in activities of daily life by constructing a self-contained, MPR-controlled, transradial prosthetic system provided with a novel user interface meant to log errors during real-time operation. The system was used for five days by a unilateral dysmelia subject whose hand had never developed, and who nevertheless learned to generate patterns of myoelectric activity, reported as intuitive, for multi-functional prosthetic control. The subject was instructed to manually log errors when they occurred via the user interface mounted on the prosthesis. This allowed the collection of information about prosthesis usage and real-time classification accuracy. The assessment of capacity for myoelectric control test was used to compare the proposed approach to the conventional prosthetic control approach, direct control. Regarding the MPR approach, the subject reported a more intuitive control when selecting the different grips, but also a higher uncertainty during proportional continuous movements. This paper represents an alternative to the conventional use of MPR, and this alternative may be particularly suitable for a certain type of amputee patients. Moreover, it represents a further validation of MPR with dysmelia cases.

Using Evolutionary Theory to Guide Mental Health Research.

PubMed

Durisko, Zachary; Mulsant, Benoit H; McKenzie, Kwame; Andrews, Paul W

2016-03-01

Evolutionary approaches to medicine can shed light on the origins and etiology of disease. Such an approach may be especially useful in psychiatry, which frequently addresses conditions with heterogeneous presentation and unknown causes. We review several previous applications of evolutionary theory that highlight the ways in which psychiatric conditions may persist despite and because of natural selection. One lesson from the evolutionary approach is that some conditions currently classified as disorders (because they cause distress and impairment) may actually be caused by functioning adaptations operating "normally" (as designed by natural selection). Such conditions suggest an alternative illness model that may generate alternative intervention strategies. Thus, the evolutionary approach suggests that psychiatry should sometimes think differently about distress and impairment. The complexity of the human brain, including normal functioning and potential for dysfunctions, has developed over evolutionary time and has been shaped by natural selection. Understanding the evolutionary origins of psychiatric conditions is therefore a crucial component to a complete understanding of etiology. © The Author(s) 2016.

Using Evolutionary Theory to Guide Mental Health Research

PubMed Central

Mulsant, Benoit H.; McKenzie, Kwame; Andrews, Paul W.

2016-01-01

Evolutionary approaches to medicine can shed light on the origins and etiology of disease. Such an approach may be especially useful in psychiatry, which frequently addresses conditions with heterogeneous presentation and unknown causes. We review several previous applications of evolutionary theory that highlight the ways in which psychiatric conditions may persist despite and because of natural selection. One lesson from the evolutionary approach is that some conditions currently classified as disorders (because they cause distress and impairment) may actually be caused by functioning adaptations operating “normally” (as designed by natural selection). Such conditions suggest an alternative illness model that may generate alternative intervention strategies. Thus, the evolutionary approach suggests that psychiatry should sometimes think differently about distress and impairment. The complexity of the human brain, including normal functioning and potential for dysfunctions, has developed over evolutionary time and has been shaped by natural selection. Understanding the evolutionary origins of psychiatric conditions is therefore a crucial component to a complete understanding of etiology. PMID:27254091

Alternative ways of modulating JAK-STAT pathway

PubMed Central

2012-01-01

Most attempts to develop inhibitors of STAT transcription factors target either activating phosphorylation of tyrosine residue or SH2 domains. However, all six domains of STATs are highly conserved between the species and play important roles in the function of this family of transcription factors. STATs are involved in numerous protein-protein interactions that are likely to regulate and fine tune transcriptional activity. Targeting these interactions can provide plentiful opportunities for the discovery of novel drug candidates and powerful chemical biology tools. Using N-terminal domains as an example we describe alternative rational approaches to the development of modulators of JAK-STAT signaling. PMID:24058784

Molecular and chemical engineering of bacteriophages for potential medical applications.

PubMed

Hodyra, Katarzyna; Dąbrowska, Krystyna

2015-04-01

Recent progress in molecular engineering has contributed to the great progress of medicine. However, there are still difficult problems constituting a challenge for molecular biology and biotechnology, e.g. new generation of anticancer agents, alternative biosensors or vaccines. As a biotechnological tool, bacteriophages (phages) offer a promising alternative to traditional approaches. They can be applied as anticancer agents, novel platforms in vaccine design, or as target carriers in drug discovery. Phages also offer solutions for modern cell imaging, biosensor construction or food pathogen detection. Here we present a review of bacteriophage research as a dynamically developing field with promising prospects for further development of medicine and biotechnology.

Recent advances in rational approaches for enzyme engineering

PubMed Central

Steiner, Kerstin; Schwab, Helmut

2012-01-01

Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks. To meet the requirements of industrial biotechnology and to introduce new functionalities, the enzymes need to be optimized by protein engineering. This article specifically reviews rational approaches for enzyme engineering and de novo enzyme design involving structure-based approaches developed in recent years for improvement of the enzymes’ performance, broadened substrate range, and creation of novel functionalities to obtain products with high added value for industrial applications. PMID:24688651

Transurethral ultrasound-guided laser-induced prostatectomy

NASA Astrophysics Data System (ADS)

Babayan, Richard K.; Roth, Robert A.

1991-07-01

A transurethral ultrasound-guided Nd:YAG laser delivery system has been developed for use as an alternative approach to the treatment of benign prostatic hyperplasia. The TULIP system has been extensively tested in canine models and is currently undergoing FDA trials in humans.

Fire Safety of Passenger Trains: A Review of U.S. and Foreign Approaches

DOT National Transportation Integrated Search

1993-12-01

could develop into potentially life-threatening events. Fire safety is an area of particular interest for both : conventional intercity and commuter trains, as well as new alternative high-speed train technologies. These : technologies include steel-...

High-Throughput Screening in ToxCast/Tox21 (FutureToxII)

EPA Science Inventory

Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However, the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. The EPA’s ToxCast program addresses th...

Multivariate Models for Prediction of Human Skin Sensitization Hazard.

EPA Science Inventory

One of the lnteragency Coordinating Committee on the Validation of Alternative Method's (ICCVAM) top priorities is the development and evaluation of non-animal approaches to identify potential skin sensitizers. The complexity of biological events necessary to produce skin sensiti...

Detecting Developmental Neurotoxicants Using Zebrafish Embryos

EPA Science Inventory

As part of EPA’s program on the screening and prioritization of chemicals for developmental neurotoxicity, a rapid, cost-effective in vivo vertebrate screen is being developed using an alternative species approach. Zebrafish (Danio rerio), a small freshwater fish with external f...

It Takes Two to Tango: Studying How Students Constitute Political Subjects in Discourses on Sustainable Development

ERIC Educational Resources Information Center

Lundegard, Iann; Wickman, Per-Olof

2012-01-01

A great deal of the ongoing discussion about environmental education and education for sustainable development has to do with democracy and deliberation. Here, for example, the normative approach has been challenged. As an alternative, there is sometimes a call for a curriculum and education that is characterized by democracy, participation, and…

Using a Student-Directed Teaching Philosophy Statement to Assess and Improve One's Teaching

ERIC Educational Resources Information Center

Brinthaupt, Thomas M.; Decker, Stephen C.; Lawrence, Robert

2014-01-01

Faculty members traditionally develop a teaching philosophy statement (TPS) as part of the job application process, for tenure reviews, or to encourage reflection. In this paper, we propose an alternative approach--to develop the TPS with students as the primary target audience, distribute it to students at the beginning of a course, and collect…

Development of polyion-complex hydrogels as an alternative approach for the production of bio-based polymers for food packaging applications: A review

USDA-ARS?s Scientific Manuscript database

Development of packaging materials from renewable resources has for a long time been desirable for sustainability reasons, but with the recent explosion in prices of petroleum products, this now becomes also more economically viable. This paper shows how fundamental chemistry underlying three forms ...

Public Marketing: An Alternative Policy Decision-Making Idea for Small Cities. Community Development Research Series.

ERIC Educational Resources Information Center

Meyers, James; And Others

The concept of public marketing presents a strategy for the systems approach to community development that would facilitate the community decision making process via improved communication. Basic aspects of the social marketing process include: (1) product policy; (2) channels of distribution; (3) pricing (perceived price vs quality and quantity…

An Investigation of Two Methods of Teaching Poetry to Children in the Fourth Grade.

ERIC Educational Resources Information Center

Shapiro, Phyllis Pearl

To develop an adequate methodology for helping children to express themselves poetically, two alternative programs for the teaching of poetry writing were developed. The "free" approach, which attempted to encourage the writing of poetry through exposure to "good" poetry, consisted of a series of poems arranged around selected elements of poetry…

Who Is Not Sleeping with Whom? What's Not Being Talked about in HRD?

ERIC Educational Resources Information Center

Trehan, Kiran

2004-01-01

Human resource development (HRD) occupies some interesting educational territory. Given the rapid pace of development and innovation in education and in the practice of HRD, coupled with alternative approaches to learning, a re-evaluation of HRD might be expected to be a prominent feature within discussions of the future practice of HRD. However,…

Holistic Understanding in Geography Education (HUGE)--An Alternative Approach to Curriculum Development and Learning at Key Stage 3

ERIC Educational Resources Information Center

Renshaw, Simon; Wood, Phil

2011-01-01

This article reports the results of a small-scale curriculum development project focusing on two of the seven "key concepts" identified in the revised Key Stage 3 (KS3) National Curriculum programme of study for geography, introduced into schools in 2007. The study used "interdependence" and "physical processes" as…

Adverse Outcome Pathways and Systems Biology as Conceptual Approaches to Support Development of 21st Century Test Methods and Extrapolation Tools

EPA Science Inventory

The proposed paradigm for “Toxicity Testing in the 21st Century” supports the development of mechanistically-based, high-throughput in vitro assays as a potential cost effective and scientifically-sound alternative to some whole animal hazard testing. To accomplish this long-term...

Pharmacological interventions to treat phlebitis: systematic review.

PubMed

dos Reis, Paula Elaine Diniz; Silveira, Renata Cristina de Campos Pereira; Vasques, Christiane Inocêncio; de Carvalho, Emilia Campos

2009-01-01

This study presents a systematic review for evaluating effective pharmacological actions for the treatment of phlebitis stemming from infusion therapy. The studies reviewed were categorized according to the type of therapeutic approach proposed by the author and by the level of evidence presented. The review found that topical nitroglycerin and notoginseny were more effective in the reduction of the inflammatory process when compared with other proposed alternatives. Nevertheless, the development of research related to possible alternatives for the treatment of phlebitis is important.

The reconstruction of narrative identity during mental health recovery: a complex adaptive systems perspective.

PubMed

Kerr, Douglas J R; Crowe, Trevor P; Oades, Lindsay G

2013-06-01

1) to understand the reconstruction of narrative identity during mental health recovery using a complex adaptive systems perspective, 2) to address the need for alternative approaches that embrace the complexities of health care. A narrative review of published literature was conducted. A complex adaptive systems perspective offers a framework and language that can assist individuals to make sense of their experiences and reconstruct their narratives during an often erratic and uncertain life transition. It is a novel research direction focused on a critical area of recovery and addresses the need for alternative approaches that embrace the complexities of health care. A complexity research approach to narrative identity reconstruction is valuable. It is an accessible model for addressing the complexities of recovery and may underpin the development of simple, practical recovery coaching tools. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Incremental Transductive Learning Approaches to Schistosomiasis Vector Classification

NASA Astrophysics Data System (ADS)

Fusco, Terence; Bi, Yaxin; Wang, Haiying; Browne, Fiona

2016-08-01

The key issues pertaining to collection of epidemic disease data for our analysis purposes are that it is a labour intensive, time consuming and expensive process resulting in availability of sparse sample data which we use to develop prediction models. To address this sparse data issue, we present the novel Incremental Transductive methods to circumvent the data collection process by applying previously acquired data to provide consistent, confidence-based labelling alternatives to field survey research. We investigated various reasoning approaches for semi-supervised machine learning including Bayesian models for labelling data. The results show that using the proposed methods, we can label instances of data with a class of vector density at a high level of confidence. By applying the Liberal and Strict Training Approaches, we provide a labelling and classification alternative to standalone algorithms. The methods in this paper are components in the process of reducing the proliferation of the Schistosomiasis disease and its effects.

Language acquisition for deaf children: Reducing the harms of zero tolerance to the use of alternative approaches.

PubMed

Humphries, Tom; Kushalnagar, Poorna; Mathur, Gaurav; Napoli, Donna Jo; Padden, Carol; Rathmann, Christian; Smith, Scott R

2012-04-02

Children acquire language without instruction as long as they are regularly and meaningfully engaged with an accessible human language. Today, 80% of children born deaf in the developed world are implanted with cochlear devices that allow some of them access to sound in their early years, which helps them to develop speech. However, because of brain plasticity changes during early childhood, children who have not acquired a first language in the early years might never be completely fluent in any language. If they miss this critical period for exposure to a natural language, their subsequent development of the cognitive activities that rely on a solid first language might be underdeveloped, such as literacy, memory organization, and number manipulation. An alternative to speech-exclusive approaches to language acquisition exists in the use of sign languages such as American Sign Language (ASL), where acquiring a sign language is subject to the same time constraints of spoken language development. Unfortunately, so far, these alternatives are caught up in an "either - or" dilemma, leading to a highly polarized conflict about which system families should choose for their children, with little tolerance for alternatives by either side of the debate and widespread misinformation about the evidence and implications for or against either approach. The success rate with cochlear implants is highly variable. This issue is still debated, and as far as we know, there are no reliable predictors for success with implants. Yet families are often advised not to expose their child to sign language. Here absolute positions based on ideology create pressures for parents that might jeopardize the real developmental needs of deaf children. What we do know is that cochlear implants do not offer accessible language to many deaf children. By the time it is clear that the deaf child is not acquiring spoken language with cochlear devices, it might already be past the critical period, and the child runs the risk of becoming linguistically deprived. Linguistic deprivation constitutes multiple personal harms as well as harms to society (in terms of costs to our medical systems and in loss of potential productive societal participation).

Advances in the high performance polymer electrolyte membranes for fuel cells.

PubMed

Zhang, Hongwei; Shen, Pei Kang

2012-03-21

This critical review tersely and concisely reviews the recent development of the polymer electrolyte membranes and the relationship between their properties and affecting factors like operation temperature. In the first section, the advantages and shortcomings of the corresponding polymer electrolyte membrane fuel cells are analyzed. Then, the limitations of Nafion membranes and their alternatives to large-scale commercial applications are discussed. Secondly, the concepts and approaches of the alternative proton exchange membranes for low temperature and high temperature fuel cells are described. The highlights of the current scientific achievements are given for various aspects of approaches. Thirdly, the progress of anion exchange membranes is presented. Finally, the perspectives of future trends on polymer electrolyte membranes for different applications are commented on (400 references).

Three dimensional magnetic fields in extra high speed modified Lundell alternators computed by a combined vector-scalar magnetic potential finite element method

NASA Technical Reports Server (NTRS)

Demerdash, N. A.; Wang, R.; Secunde, R.

1992-01-01

A 3D finite element (FE) approach was developed and implemented for computation of global magnetic fields in a 14.3 kVA modified Lundell alternator. The essence of the new method is the combined use of magnetic vector and scalar potential formulations in 3D FEs. This approach makes it practical, using state of the art supercomputer resources, to globally analyze magnetic fields and operating performances of rotating machines which have truly 3D magnetic flux patterns. The 3D FE-computed fields and machine inductances as well as various machine performance simulations of the 14.3 kVA machine are presented in this paper and its two companion papers.

Information systems analysis approach in hospitals: a national survey.

PubMed

Wong, B K; Sellaro, C L; Monaco, J A

1995-03-01

A survey of 216 hospitals reveals that some hospitals do not conduct cost-benefit analyses or analyze possible adverse effects in feasibility studies. In determining and analyzing system requirements, external factors that initiate the transaction are not examined, and computer-aided software engineering (CASE) tools are seldom used. Some hospitals do not investigate the advantages and disadvantages of using in-house-developed software versus purchased software packages in the evaluation of alternatives. The survey finds that, overall, most hospitals follow the traditional systems development life cycle (SDLC) approach in analyzing information systems.

Justice foundations for the Comprehensive Law Movement.

PubMed

Dewhurst, Dale

2010-01-01

Authors examining the developing dispute resolution alternatives to the adversarial system have identified nine converging "vectors" or alternatives in what has been termed the Comprehensive Law Movement. These authors have sought to understand how the developing vectors can remain separate and vibrant movements while sharing common ground. Some analyze these developments as being within law and legal practice, others see them as alternative approaches to law, and still others take a combined approach. It will be impossible to understand how these vectors have meaningful differences from law and legal practice if the search is limited to looking within law and legal practice. It will be impossible to understand how these vectors have meaningful commonalities with law and legal practice if the search is limited to looking external to law and legal practice. Instead of comparing the vectors with the adversarial system, higher order criteria are required. What is needed is a comprehensive and internally consistent super-system of norms; one that can be used to evaluate the adversarial system and the evolving vectors on an equal footing. An Aristotelian natural law virtue theory of justice can: (a) provide a functional guiding definition of justice; (b) serve as a comprehensive and internally consistent super-system of norms; and (c) provide the theoretical and evaluative foundation required to clarify the relationships among the adversarial system and the developing vectors. Finally, it will become clear why the Comprehensive Law Movement might be more appropriately conceptualized as the Comprehensive Justice Movement. Copyright © 2010 Elsevier Ltd. All rights reserved.

Male contraception

PubMed Central

Chao, Jing; Page, Stephanie T.; Anderson, Richard A.

2015-01-01

Clear evidence shows that many men and women would welcome new male methods of contraception, but none have become available. The hormonal approach is based on suppression of gonadotropins and thus of testicular function and spermatogenesis, and has been investigated for several decades. This approach can achieve sufficient suppression of spermatogenesis for effective contraception in most men, but not all; the basis for these men responding insufficiently is unclear. Alternatively, the nonhormonal approach is based on identifying specific processes in sperm development, maturation and function. A range of targets has been identified in animal models, and targeted effectively. This approach, however, remains in the pre-clinical domain at present. There are, therefore, grounds for considering that safe, effective and reversible methods of contraception for men can be developed. PMID:24947599

Theoretical orientations in environmental planning: An inquiry into alternative approaches

NASA Astrophysics Data System (ADS)

Briassoulis, Helen

1989-07-01

In the process of devising courses of action to resolve problems arising at the society-environment interface, a variety of planning approaches are followed, whose adoption is influenced by—among other things—the characteristics of environmental problems, the nature of the decision-making context, and the intellectual traditions of the disciplines contributing to the study of these problems. This article provides a systematic analysis of six alternative environmental planning approaches—comprehensive/rational, incremental, adaptive, contingency, advocacy, and participatory/consensual. The relative influence of the abovementioned factors is examined, the occurrence of these approaches in real-world situations is noted, and their environmental soundness and political realism is evaluated. Because of the disparity between plan formulation and implementation and between theoretical form and empirical reality, a synthetic view of environmental planning approaches is taken and approaches in action are identified, which characterize the totality of the planning process from problem definition to plan implementation, as well as approaches in the becoming, which may be on the horizon of environmental planning of tomorrow. The suggested future research directions include case studies to verify and detail the presence of the approaches discussed, developing measures of success of a given approach in a given decision setting, and an intertemporal analysis of environmental planning approaches.

Reference condition approach to restoration planning

USGS Publications Warehouse

Nestler, J.M.; Theiling, C.H.; Lubinski, S.J.; Smith, D.L.

2010-01-01

Ecosystem restoration planning requires quantitative rigor to evaluate alternatives, define end states, report progress and perform environmental benefits analysis (EBA). Unfortunately, existing planning frameworks are, at best, semi-quantitative. In this paper, we: (1) describe a quantitative restoration planning approach based on a comprehensive, but simple mathematical framework that can be used to effectively apply knowledge and evaluate alternatives, (2) use the approach to derive a simple but precisely defined lexicon based on the reference condition concept and allied terms and (3) illustrate the approach with an example from the Upper Mississippi River System (UMRS) using hydrologic indicators. The approach supports the development of a scaleable restoration strategy that, in theory, can be expanded to ecosystem characteristics such as hydraulics, geomorphology, habitat and biodiversity. We identify three reference condition types, best achievable condition (A BAC), measured magnitude (MMi which can be determined at one or many times and places) and desired future condition (ADFC) that, when used with the mathematical framework, provide a complete system of accounts useful for goal-oriented system-level management and restoration. Published in 2010 by John Wiley & Sons, Ltd.

Achieving Millennium Development Goals for Health: Building Understanding, Trust and Capacity to Respond

PubMed Central

Larson, Heidi J.

2007-01-01

Biomedical interventions promise achievement of health-related Millennium Development Goals provided social-, capacity- and knowledge-based constraints to scaling up and reaching marginalized people at risk, are addressed, and balance between prevention and treatment is struck. We argue for a new approach: multi-stakeholder capacity building and learning for empowerment: MuSCLE. MuSCLE is used as a way to frame three systemic weaknesses in traditional health science and policy approaches: 1) a lack of engagement with people at risk to build a collective understanding of the contexts of health problems; 2) a lack of multi-criteria evaluation of alternative interventions; and 3) a lack of attention paid to integrated capacity building. The MuSCLE framework responds in three ways: 1) Participatory assessment of the ecological, socio-cultural, economic and political contexts of health, identifying priorities using risk and vulnerability science, and modeling drivers; 2) Selection among intervention alternatives that makes ecological, socio-cultural, economic and political tradeoffs transparent; and 3) Integrated capacity building for sustainable and adaptive interventions. Literature and field lessons support the argument, and guidelines are set down. A MuSCLE approach argues for a transformation in health science and policy in order to achieve Millennium Development Goals for health. PMID:17399849

Achieving Millennium Development Goals for health: building understanding, trust and capacity to respond.

PubMed

Downs, Timothy John; Larson, Heidi Jane

2007-10-01

Biomedical interventions promise achievement of health-related Millennium Development Goals provided social-, capacity- and knowledge-based constraints to scaling up and reaching marginalized people at risk, are addressed, and balance between prevention and treatment is struck. We argue for a new approach: multi-stakeholder capacity building and learning for empowerment: MuSCLE. MuSCLE is used as a way to frame three systemic weaknesses in traditional health science and policy approaches: (1) a lack of engagement with people at risk to build a collective understanding of the contexts of health problems, including social drivers; (2) a lack of multi-criteria evaluation of alternative interventions; (3) a lack of attention paid to integrated capacity building. The MuSCLE framework responds in three ways: (1) participatory assessment of the ecological, socio-cultural, economic and political contexts of health, identifying priorities using risk and vulnerability science, and modeling drivers; (2) selection among intervention alternatives that makes ecological, socio-cultural, economic and political tradeoffs transparent; (3) integrated capacity building for sustainable and adaptive interventions. Literature and field lessons support the argument, and guidelines are set down. A MuSCLE approach argues for a transformation in health science and policy in order to achieve Millennium Development Goals for health.

Identifying Complementary and Alternative Medicine Usage Information from Internet Resources. A Systematic Review.

PubMed

Sharma, Vivekanand; Holmes, John H; Sarkar, Indra N

2016-08-05

Identify and highlight research issues and methods used in studying Complementary and Alternative Medicine (CAM) information needs, access, and exchange over the Internet. A literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines from PubMed to identify articles that have studied Internet use in the CAM context. Additional searches were conducted at Nature.com and Google Scholar. The Internet provides a major medium for attaining CAM information and can also serve as an avenue for conducting CAM related surveys. Based on the literature analyzed in this review, there seems to be significant interest in developing methodologies for identifying CAM treatments, including the analysis of search query data and social media platform discussions. Several studies have also underscored the challenges in developing approaches for identifying the reliability of CAM-related information on the Internet, which may not be supported with reliable sources. The overall findings of this review suggest that there are opportunities for developing approaches for making available accurate information and developing ways to restrict the spread and sale of potentially harmful CAM products and information. Advances in Internet research are yet to be used in context of understanding CAM prevalence and perspectives. Such approaches may provide valuable insights into the current trends and needs in context of CAM use and spread.

IDENTIFYING COMPLEMENTARY AND ALTERNATIVE MEDICINE USAGE INFORMATION FROM INTERNET RESOURCES: A SYSTEMATIC REVIEW

PubMed Central

Sharma, V.; Holmes, J.H.; Sarkar, I.N.

2016-01-01

SUMMARY Objective Identify and highlight research issues and methods used in studying Complementary and Alternative Medicine (CAM) information needs, access, and exchange over the Internet. Methods A literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines from PubMed to identify articles that have studied Internet use in the CAM context. Additional searches were conducted at Nature.com and Google Scholar. Results The Internet provides a major medium for attaining CAM information and can also serve as an avenue for conducting CAM related surveys. Based on the literature analyzed in this review, there seems to be significant interest in developing methodologies for identifying CAM treatments, including the analysis of search query data and social media platform discussions. Several studies have also underscored the challenges in developing approaches for identifying the reliability of CAM-related information on the Internet, which may not be supported with reliable sources. The overall findings of this review suggest that there are opportunities for developing approaches for making available accurate information and developing ways to restrict the spread and sale of potentially harmful CAM products and information. Conclusions Advances in Internet research are yet to be used in context of understanding CAM prevalence and perspectives. Such approaches may provide valuable insights into the current trends and needs in context of CAM use and spread. PMID:27352304

Evolutionary Concepts for Decentralized Air Traffic Flow Management

NASA Technical Reports Server (NTRS)

Adams, Milton; Kolitz, Stephan; Milner, Joseph; Odoni, Amedeo

1997-01-01

Alternative concepts for modifying the policies and procedures under which the air traffic flow management system operates are described, and an approach to the evaluation of those concepts is discussed. Here, air traffic flow management includes all activities related to the management of the flow of aircraft and related system resources from 'block to block.' The alternative concepts represent stages in the evolution from the current system, in which air traffic management decision making is largely centralized within the FAA, to a more decentralized approach wherein the airlines and other airspace users collaborate in air traffic management decision making with the FAA. The emphasis in the discussion is on a viable medium-term partially decentralized scenario representing a phase of this evolution that is consistent with the decision-making approaches embodied in proposed Free Flight concepts for air traffic management. System-level metrics for analyzing and evaluating the various alternatives are defined, and a simulation testbed developed to generate values for those metrics is described. The fundamental issue of modeling airline behavior in decentralized environments is also raised, and an example of such a model, which deals with the preservation of flight bank integrity in hub airports, is presented.

Nursing Home Levels of Care: Reimbursement of Resident Specific Costs

PubMed Central

Willemain, Thomas R.

1980-01-01

The companion paper on nursing home levels of care (Bishop, Plough and Willemain, 1980) recommended a “split-rate” approach to nursing home reimbursement that would distinguish between fixed and variable costs. This paper examines three alternative treatments of the variable cost component of the rate: a two-level system similar to the distinction between skilled and intermediate care facilities, an individualized (“patient-centered”) system, and a system that assigns a single facility-specific rate that depends on the facility's case-mix (“case-mix reimbursement”). The aim is to better understand the theoretical strengths and weaknesses of these three approaches. The comparison of reimbursement alternatives is framed in terms of minimizing reimbursement error, meaning overpayment and underpayment. We develop a conceptual model of reimbursement error that stresses that the features of the reimbursement scheme are only some of the factors contributing to over- and underpayment. The conceptual model is translated into a computer program for quantitative comparison of the alternatives. PMID:10309330

Constrained optimization by radial basis function interpolation for high-dimensional expensive black-box problems with infeasible initial points

NASA Astrophysics Data System (ADS)

Regis, Rommel G.

2014-02-01

This article develops two new algorithms for constrained expensive black-box optimization that use radial basis function surrogates for the objective and constraint functions. These algorithms are called COBRA and Extended ConstrLMSRBF and, unlike previous surrogate-based approaches, they can be used for high-dimensional problems where all initial points are infeasible. They both follow a two-phase approach where the first phase finds a feasible point while the second phase improves this feasible point. COBRA and Extended ConstrLMSRBF are compared with alternative methods on 20 test problems and on the MOPTA08 benchmark automotive problem (D.R. Jones, Presented at MOPTA 2008), which has 124 decision variables and 68 black-box inequality constraints. The alternatives include a sequential penalty derivative-free algorithm, a direct search method with kriging surrogates, and two multistart methods. Numerical results show that COBRA algorithms are competitive with Extended ConstrLMSRBF and they generally outperform the alternatives on the MOPTA08 problem and most of the test problems.

Nursing home levels of care: reimbursement of resident specific costs.

PubMed

Willemain, T R

1980-01-01

The companion paper on nursing home levels of care (Bishop, Plough and Willemain, 1980) recommended a "split-rate" approach to nursing home reimbursement that would distinguish between fixed and variable costs. This paper examines three alternative treatments of the variable cost component of the rate: a two-level system similar to the distinction between skilled and intermediate care facilities, an individualized ("patient-centered") system, and a system that assigns a single facility-specific rate that depends on the facility's case-mix ("case-mix reimbursement"). The aim is to better understand the theoretical strengths and weaknesses of these three approaches. The comparison of reimbursement alternatives is framed in terms of minimizing reimbursement error, meaning overpayment and underpayment. We develop a conceptual model of reimbursement error that stresses that the features of the reimbursement scheme are only some of the factors contributing to over- and underpayment. The conceptual model is translated into a computer program for quantitative comparison of the alternatives.

Summary of laser speckle photogrammetry for HOST

NASA Technical Reports Server (NTRS)

Pollack, Frank G.

1986-01-01

High temperature static strain measurement capability is important for the success of the HOST program. As part of the NASA Lewis effort to develop the technology for improved hot-section durability, the HOST instrumentation program has, as a major goal, the development of methods for measuring strain at high temperature. Development work includes both improvements in resistance strain-gauge technology and, as an alternative approach, the development of optical techniques for high temperature strain measurement.

[Communication in medicine: a new and much needed curricular alternative].

PubMed

Halac, Eduardo; Quiroga, Daniel; Olmas, Josè M; Trucchia, Silvina M

2016-01-01

Medical education must emphasize communication practices mostly for undergraduate medical students. To introduce an approach for teaching and learning communication in medicine. An approach for developing communicational practices for both undergraduate and post graduate students is presented. Medical communication is not taught adequately in modern medical schools and is allotted a brief curricular space.. This curricular time must be widened in order to support communication's central role.

Potential Alternatives to Classical Biocontrol: Using Native Agents in Invaded Habitats and Genetically Engineered Sterile Cultivars for Invasive Plant Management

Treesearch

ShiLi Miao; Yi Li; Qinfeng Guo; Hua Yu; JiangQing Ding; et al.

2012-01-01

The development of an effective approach to control and eradication of invasive species has become a major challenge to scientists, managers, and society. Biocontrol has been widely utilized to control exotic plants in the past few decades with some degree of sucess. However, there have been an increasing number of controversies pertaining to this approach, largely...

An approach for assessing software prototypes

NASA Technical Reports Server (NTRS)

Church, V. E.; Card, D. N.; Agresti, W. W.; Jordan, Q. L.

1986-01-01

A procedure for evaluating a software prototype is presented. The need to assess the prototype itself arises from the use of prototyping to demonstrate the feasibility of a design or development stategy. The assessment procedure can also be of use in deciding whether to evolve a prototype into a complete system. The procedure consists of identifying evaluations criteria, defining alterative design approaches, and ranking the alternatives according to the criteria.

Multivariate Models for Prediction of Skin Sensitization Hazard in Humans

EPA Science Inventory

One of ICCVAM’s highest priorities is the development and evaluation of non-animal approaches to identify potential skin sensitizers. The complexity of biological events necessary for a substance to elicit a skin sensitization reaction suggests that no single alternative me...

MODIFYING THE AVIAN REPRODUCTION TEST GUIDELINES FOR DETERMINING DOSE-RESPONSE RELATIONSHIPS

EPA Science Inventory

As a subgroup of the OECD Expert Group on Assessment of Endocrine Disrupting Effects in Birds, we reviewed unresolved methodological issues important for the development of a two-generation toxicity text, discussed advantages and disadvantages of alternative approaches, and propo...

Educational Cost-Benefit Analysis.

ERIC Educational Resources Information Center

Hough, J. R.

1994-01-01

Educational cost-benefit analysis, as practiced in both industrialized and developing nations, has been much criticized. Manpower planning, the principal alternative, has received even harsher criticism. The two approaches should be combined in empirically based projects that study recent graduates and chart their subsequent employment progress.…

Vertical integration from the large Hilbert space

NASA Astrophysics Data System (ADS)

Erler, Theodore; Konopka, Sebastian

2017-12-01

We develop an alternative description of the procedure of vertical integration based on the observation that amplitudes can be written in BRST exact form in the large Hilbert space. We relate this approach to the description of vertical integration given by Sen and Witten.

Multivariate Models for Prediction of Human Skin Sensitization Hazard

EPA Science Inventory

One of ICCVAM’s top priorities is the development and evaluation of non-animal approaches to identify potential skin sensitizers. The complexity of biological events necessary for a substance to elicit a skin sensitization reaction suggests that no single alternative method...

Perspectives on evolving dental care payment and delivery models.

PubMed

Rubin, Marcie S; Edelstein, Burton L

2016-01-01

Health care reform is well under way in the United States as reflected in evolving delivery, financing, and payment approaches that are affecting medicine ahead of dentistry. The authors explored health systems changes under way, distinguished historical and organizational differences between medicine and dentistry, and developed alternative models to characterize the relationships between these professions. The authors explored a range of medical payment approaches, including those tied to objective performance metrics, and their potential application to dentistry. Advances in understanding the essential role of oral health in general health have pulled dentistry into the broader discussion of care integration and payment reform. Dentistry's fit with primary and specialty medical care may take a variety of forms. Common provider payment approaches in dentistry-fee-for-service, capitation, and salary-are tied insufficiently to performance when measured as either health processes or health outcomes. Dentistry can anticipate potential payment reforms by observing changes already under way in medicine and by understanding alternative payment approaches that are tied to performance metrics, such as those now in development by the Dental Quality Alliance and others. Novel forms of dental practice may be expected to evolve continuously as medical-dental integration and payment reforms that promote accountability evolve. Copyright © 2016 American Dental Association. Published by Elsevier Inc. All rights reserved.

Alternative approaches to control--quo vadit?

PubMed

Jackson, Frank; Miller, Jim

2006-07-31

The increasing prevalence of anthelmintic resistance has provided a spur for research into 'alternative/novel' approaches to the control of helminthoses that are intended to reduce our reliance upon using chemoprophylaxis. The different approaches either target the parasite population in the host or on pasture, but the goal of all of them is to restrict host parasite contact to levels which minimise the impact of helminths on host welfare and/or performance. Infrapopulation regulation can be achieved through methods that enhance immunity such as optimised nutrition (immunonutrition), genetic selection and vaccination, or by an 'anthelmintic' route using bioactive forages, copper oxide wire particles, or use of targeted selective treatment strategies such as FAMACHA, which reduce the selection pressure for the development of resistance by maintaining a population in refugia. Suprapopulation control can be achieved through grazing management, or by using predacious fungi such as Duddingtonia flagrans. All of these approaches have been developed beyond the proof of concept stage and some are capable of being employed currently. However, some still require knowledge transfer, or commercialisation before they can be tested and widely applied in the field. All of the different approaches present unique challenges to the researchers engaged in developing them, and in comparison to simple prescriptive anthelmintic treatments, their use appears complex and requires some expertise on behalf of the advisor and/or end user. At present, most of our data are derived from trials using single approaches, but it is apparent that we need to move towards integrating some of these technologies which again represents a further challenge to the extension/advisory services. Progress in establishing different approaches requires not only the funding to support their scientific development but also to support the development of computer based models which can be used to highlight deficiencies in our understanding of the control mechanisms and to identify impediments to their introduction. It is inevitable that some of the approaches currently under investigation will fail to become widely applied for a variety of reasons that are not solely financial. These include issues concerned with practicability/applicability, affordability/appropriateness, availability/deliverability and above all, the failure to provide a consistent, reliable effect when used under commercial farming conditions.

Education for change in a post-modern world: redefining revolution.

PubMed

Cameron, P; Willis, K; Crack, G

1995-10-01

Social and behavioural sciences are established components in the curriculum of undergraduate nursing degrees. The purpose is to introduce future and practising nurses to the social and political influences which inform their workplaces and practices. Inevitably an awareness of the structural barriers and the powerful political interests involved in health can lead to feelings of powerlessness and despair of achieving change. Yet the skills of critical analysis and political awareness developed in study such as this are essential for health workers in the increasingly complex and politically charged domain in which they work. This paper will explore problems and barriers encountered in development of curriculum and teaching social and behavioural sciences in health. It will propose an alternative conceptual model, based on post-structuralism, as one way of addressing these barriers. This approach shifts the focus from meta-theoretical sociological concepts such as class, gender and culture, to one of examining subject positions, discourse, contestation and local action, thus enabling the exploration and development of possibilities for change. The paper will also provide a case study to illustrate this alternative approach.

Space power system design and development from an economic point of view

NASA Technical Reports Server (NTRS)

Hazelrigg, G. A., Jr.

1977-01-01

The concept of a satellite solar power system offers a feasible, but unproven, long-range energy alternative. While the basic physics of these systems is understood, many developments are necessary in order to reduce the system cost to the point of being cost-competitive with alternative energy sources. Thus, a substantial technology advancement and verification program, plus test and demonstration satellite programs are necessary before a full-scale satellite can be designed and built. It is important to properly identify those elements of the technology that should be subject to development efforts, the goals of the corresponding development programs and the appropriate funding levels and schedules. Systems studies and designs play a major role in rationally formulating a development program. This paper uses an economic approach to place these studies into a framework for formulating a viable satellite solar power system development plan.

Automated Platform Management System Scheduling

NASA Technical Reports Server (NTRS)

Hull, Larry G.

1990-01-01

The Platform Management System was established to coordinate the operation of platform systems and instruments. The management functions are split between ground and space components. Since platforms are to be out of contact with the ground more than the manned base, the on-board functions are required to be more autonomous than those of the manned base. Under this concept, automated replanning and rescheduling, including on-board real-time schedule maintenance and schedule repair, are required to effectively and efficiently meet Space Station Freedom mission goals. In a FY88 study, we developed several promising alternatives for automated platform planning and scheduling. We recommended both a specific alternative and a phased approach to automated platform resource scheduling. Our recommended alternative was based upon use of exactly the same scheduling engine in both ground and space components of the platform management system. Our phased approach recommendation was based upon evolutionary development of the platform. In the past year, we developed platform scheduler requirements and implemented a rapid prototype of a baseline platform scheduler. Presently we are rehosting this platform scheduler rapid prototype and integrating the scheduler prototype into two Goddard Space Flight Center testbeds, as the ground scheduler in the Scheduling Concepts, Architectures, and Networks Testbed and as the on-board scheduler in the Platform Management System Testbed. Using these testbeds, we will investigate rescheduling issues, evaluate operational performance and enhance the platform scheduler prototype to demonstrate our evolutionary approach to automated platform scheduling. The work described in this paper was performed prior to Space Station Freedom rephasing, transfer of platform responsibility to Code E, and other recently discussed changes. We neither speculate on these changes nor attempt to predict the impact of the final decisions. As a consequence some of our work and results may be outdated when this paper is published.

A 3-D Magnetic Analysis of a Stirling Convertor Linear Alternator Under Load

NASA Technical Reports Server (NTRS)

Geng, Steven M.; Schwarze, Gene E.; Niedra, Janis M.; Regan, Timothy F.

2001-01-01

The NASA Glenn Research Center (GRC), the Department of Energy (DOE), and the Stirling Technology Company (STC) are developing Stirling convertors for Stirling Radioisotope Power Systems (SRPS) to provide electrical power for future NASA deep space missions. STC is developing the 55-We Technology Demonstration Convertor (TDC) under contract to DOE. Of critical importance to the successful development of the Stirling convertor for space power applications is the development of a lightweight and highly efficient linear alternator. This paper presents a 3-dimensional finite element method (FEM) approach for evaluating Stirling convertor linear alternators. The model extends a magnetostatic analysis previously reported at the 35th Intersociety Energy Conversion Engineering Conference (IECEC) to include the effects of the load current. STC's 55-We linear alternator design was selected to validate the model. Spatial plots of magnetic field strength (H) are presented in the region of the exciting permanent magnets. The margin for permanent magnet demagnetization is calculated at the expected magnet operating temperature for the near earth environment and for various average magnet temperatures. These thermal conditions were selected to represent a worst-case condition for the planned deep space missions. This paper presents plots that identify regions of high H where the potential to alter the magnetic moment of the magnets exists.

DEVELOPMENT AND VALIDATION OF BROMATOMETRIC, DIAZOTIZATION AND VIS-SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF MESALAZINE IN PHARMACEUTICAL FORMULATION.

PubMed

Zawada, Elzabieta; Pirianowicz-Chaber, Elzabieta; Somogi, Aleksander; Pawinski, Tomasz

2017-03-01

Three new methods were developed for the quantitative determination of mesalazine in the form of the pure substance or in the form of suppositories and tablets - accordingly: bromatometric, diazotization and visible light spectrophotometry method. Optimizing the time and the temperature of the bromination reaction (50⁰C, 50 min) 4-amino-2,3,5,6-tetrabromophenol was obtained. The results obtained were reproducible, accurate and precise. Developed methods were compared to the pharmacopoeial approach - alkalimetry in an aqueous medium. The validation parameters of all methods were comparable. Developed methods for quantification of mesalazine are a viable alternative to other more expensive approaches.

Post-communism: postmodernity or modernity revisited?

PubMed

Ray, L

1997-12-01

Coinciding with the popularity of postmodern theory, the fall of communism appeared to offer further evidence of the exhaustion of modernity. Such analysis is grounded in a view that the Soviet system was the epitome of modernity. An alternative approach regards post-communism as opening new terrains of struggle for modernity. Thus Habermas and others suggest that post-communist societies are rejoining the trajectory of western modernity whose problems they now recapitulate. This alternative view implies that Soviet systems were something other than 'modern', although their nature is not always clearly defined. However, even if post-communist societies do encounter problems of modernity, they do so in new circumstances where modernist notions of social development have become problematic. This article argues that, contrary to those who regard modernization or postmodernization as irresistible trends, core post-communist societies are likely to develop along an alternative path to that of western modernity. This is tentatively described as 'neo-mercantilist'.

Alternative Career Formation Perspectives: Lessons for Educational Leadership from Law, Medicine, and Training for the Priesthood.

ERIC Educational Resources Information Center

Daresh, John C.; Playko, Marsha A.

One of the suggestions for improving the professional development of school leaders is to adopt some of the practices used in other professional fields. This paper explores three models of professional development traditionally followed in medicine, law, and the Catholic priesthood to assess the extent to which these approaches are likely to…

Structural dynamics payload loads estimates

NASA Technical Reports Server (NTRS)

Engels, R. C.

1982-01-01

Methods for the prediction of loads on large space structures are discussed. Existing approaches to the problem of loads calculation are surveyed. A full scale version of an alternate numerical integration technique to solve the response part of a load cycle is presented, and a set of short cut versions of the algorithm developed. The implementation of these techniques using the software package developed is discussed.

Electives: isn't it time for a change?

PubMed

Dowell, Jon; Merrylees, Neil

2009-02-01

Medical student electives are memorable learning experiences, of which approximately 40% are spent in developing countries. Students often have laudable motivation but are rarely helped to learn most effectively or contribute meaningfully whilst away. Each year an estimated 350 years of elective time is spent in developing countries (by students from the UK alone), which represents substantial opportunity. We conducted a literature search prior to developing an alternative approach towards electives based upon educational and ethical principles. Despite their anecdotal value there has been little empirical research conducted into electives. From our review we identified four key learning domains (Clinical Knowledge and Skills, Attitudes, Global Perspectives, Personal and Professional Development) and two broader issues (Institutional Benefits and Moral/Ethical Considerations). Potentially beneficial and more structured alternatives are emerging and improvements appear possible through institutional collaborations and greater planning in order to maximise the educational experience, opportunities to contribute and minimise the risks involved in electives. Electives are a highlight of clinical training but probably often represent missed opportunities. There are both educational and moral reasons for seeking more considered approaches to reduce the 'medical tourism' that can result from the current largely ad hoc arrangements.

Ranking Theory and Conditional Reasoning.

PubMed

Skovgaard-Olsen, Niels

2016-05-01

Ranking theory is a formal epistemology that has been developed in over 600 pages in Spohn's recent book The Laws of Belief, which aims to provide a normative account of the dynamics of beliefs that presents an alternative to current probabilistic approaches. It has long been received in the AI community, but it has not yet found application in experimental psychology. The purpose of this paper is to derive clear, quantitative predictions by exploiting a parallel between ranking theory and a statistical model called logistic regression. This approach is illustrated by the development of a model for the conditional inference task using Spohn's (2013) ranking theoretic approach to conditionals. Copyright © 2015 Cognitive Science Society, Inc.

The ALMA CONOPS project: the impact of funding decisions on observatory performance

NASA Astrophysics Data System (ADS)

Ibsen, Jorge; Hibbard, John; Filippi, Giorgio

2014-08-01

In time when every penny counts, many organizations are facing the question of how much scientific impact a budget cut can have or, putting it in more general terms, which is the science impact of alternative (less costly) operational modes. In reply to such question posted by the governing bodies, the ALMA project had to develop a methodology (ALMA Concepts for Operations, CONOPS) that attempts to measure the impact that alternative operational scenarios may have on the overall scientific production of the Observatory. Although the analysis and the results are ALMA specific, the developed approach is rather general and provides a methodology for a cost-performance analysis of alternatives before any radical alterations to the operations model are adopted. This paper describes the key aspects of the methodology: a) the definition of the Figures of Merit (FoMs) for the assessment of quantitative science performance impacts as well as qualitative impacts, and presents a methodology using these FoMs to evaluate the cost and impact of the different operational scenarios; b) the definition of a REFERENCE operational baseline; c) the identification of Alternative Scenarios each replacing one or more concepts in the REFERENCE by a different concept that has a lower cost and some level of scientific and/or operational impact; d) the use of a Cost-Performance plane to graphically combine the effects that the alternative scenarios can have in terms of cost reduction and affected performance. Although is a firstorder assessment, we believe this approach is useful for comparing different operational models and to understand the cost performance impact of these choices. This can be used to take decision to meet budget cuts as well as in evaluating possible new emergent opportunities.

A World Where All Worlds Cohabit

ERIC Educational Resources Information Center

Teamey, Kelly; Mandel, Udi

2016-01-01

In response to Stefan Bengtsson's search for alternatives to Education for Sustainable Development practices outside the mainstream of the state and its policy formulations, this response outlines how our journey, experiences, and approaches reflect a de-professionalizing encounter with autonomous places of learning emerging from indigenous…

Predicting Toxic and Therapeutic Mechanisms of the ToxCast Chemical Library by Phenotypic Screening (SOT)

EPA Science Inventory

Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. Using 8 primary human cell systems (Bio...

Phenotypic Screening of Primary Human Cell Culture Systems to Identify Potential for Compound Toxicity (CHI Phenotypic Screening)

EPA Science Inventory

Addressing safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals needing assessment and the challenge of species extrapolation require development of alternative approaches. Assessing phenot...

40 CFR 130.11 - Program management.

Code of Federal Regulations, 2011 CFR

2011-07-01

... quality standards (WQS), development of alternative approaches to control pollution, implementation and... primarily to manage the wastewater treatment works construction grants program pursuant to the provisions of 40 CFR part 35, subpart J. A State may also use part of the 205(g) funds to administer approved...

Developmental Systems Toxicology: computer simulation in a ‘Virtual Embryo’ prototype (SEURAT-1 Progress Meeting)

EPA Science Inventory

Evaluating and assessing impacts to development is an Agency priority (EPA’s Children’s Environmental Health Research Roadmap); however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studi...

Copula-based nonlinear modeling of the law of one price for lumber products

Treesearch

Barry K. Goodwin; Matthew T. Holt; Gülcan Önel; Jeffrey P. Prestemon

2018-01-01

This paper proposes an alternative and potentially novel approach to analyzing the law of one price in a nonlinear fashion. Copula-based models that consider the joint distribution of prices separated by space are developed and applied to weekly...

Teaching Aerobic Lifestyles: New Perspectives.

ERIC Educational Resources Information Center

Goodrick, G. Ken; Iammarino, Nicholas K.

1982-01-01

New approaches to teaching aerobic life-styles in secondary schools are suggested, focusing on three components: (1) the psychological benefits of aerobic activity; (2) alternative aerobic programs at nonschool locations; and (3) the development of an aerobics curriculum to help maintain an active life-style after graduation. (JN)

Applications in Educational Assessment: Future Technologies.

ERIC Educational Resources Information Center

Bank Street Coll. of Education, New York, NY. Center for Children and Technology.

The development of improved and alternative methods of educational assessment should take advantage of technologies that enable different aspects of learning, teaching, and student achievement to be part of an improved assessment system. The current understanding of knowledge assessment, new approaches to assessment, and technologies that may…

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

EPA Science Inventory

Addressing the safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals in need of assessment and the challenges of species extrapolation require the development of alternative approaches. Our ...

Cognitive-Developmental and Behavior-Analytic Theories: Evolving into Complementarity

ERIC Educational Resources Information Center

Overton, Willis F.; Ennis, Michelle D.

2006-01-01

Historically, cognitive-developmental and behavior-analytic approaches to the study of human behavior change and development have been presented as incompatible alternative theoretical and methodological perspectives. This presumed incompatibility has been understood as arising from divergent sets of metatheoretical assumptions that take the form…

Development of a Database for Drilled SHAft Foundation Testing (DSHAFT).

DOT National Transportation Integrated Search

2012-06-01

Drilled shafts have been used in the US for more than 100 years in bridges and buildings as a deep foundation alternative. For many of these applications, the drilled shafts were designed using the Working Stress Design (WSD) approach. Even though WS...

Tribal Ecosystem Research Program (TERP) Workshop: Proper Functioning Condition (PFC) Assessment for Management and Monitoring

EPA Science Inventory

USEPA is developing alternative approaches to quantify improvements to impaired waterbodies (USEPA 303(d)/TMDL Draft Guidance). Tribal environmental programs are leading the way in the paradigm shift towards sustainability of natural resources. Resources such as wildlife, aquatic...

Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets.

PubMed

Servín-Blanco, R; Zamora-Alvarado, R; Gevorkian, G; Manoutcharian, K

2016-10-02

Despite the impressive impact of vaccines on public health, the success of vaccines targeting many important pathogens and cancers has to date been limited. The burden of infectious diseases today is mainly caused by antigenically variable pathogens (AVPs), which escape immune responses induced by prior infection or vaccination through changes in molecular structures recognized by antibodies or T cells. Extensive genetic and antigenic variability is the major obstacle for the development of new or improved vaccines against "difficult" targets. Alternative, qualitatively new approaches leading to the generation of disease- and patient-specific vaccine immunogens that incorporate complex permanently changing epitope landscapes of intended targets accompanied by appropriate immunomodulators are urgently needed. In this review, we highlight some of the most critical common issues related to the development of vaccines against many pathogens and cancers that escape protective immune responses owing to antigenic variation, and discuss recent efforts to overcome the obstacles by applying alternative approaches for the rational design of new types of immunogens.

Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1

PubMed Central

Abdelwhab, E. M.; Hafez, Hafez M.

2012-01-01

Highly pathogenic avian influenza virus (HPAIV) of subtype H5N1 causes a devastating disease in poultry but when it accidentally infects humans it can cause death. Therefore, decrease the incidence of H5N1 in humans needs to focus on prevention and control of poultry infections. Conventional control strategies in poultry based on surveillance, stamping out, movement restriction and enforcement of biosecurity measures did not prevent the virus spreading, particularly in developing countries. Several challenges limit efficiency of the vaccines to prevent outbreaks of HPAIV H5N1 in endemic countries. Alternative and complementary approaches to reduce the current burden of H5N1 epidemics in poultry should be encouraged. The use of antiviral chemotherapy and natural compounds, avian-cytokines, RNA interference, genetic breeding and/or development of transgenic poultry warrant further evaluation as integrated intervention strategies for control of HPAIV H5N1 in poultry. PMID:23202521

Development of 10B-Based 3He Replacement Neutron Detectors

NASA Astrophysics Data System (ADS)

King, Michael J.; Gozani, Tsahi; Hilliard, Donald B.

2011-12-01

Radiation portal monitors (RPM) are currently deployed at United States border crossings to passively inspect vehicles and persons for any emission of neutrons and/or gamma rays, which may indicate the presence of unshielded nuclear materials. The RPM module contains an organic scintillator with 3He proportional counters to detect gamma rays and thermalized neutrons, respectively. The supply of 3He is rapidly dwindling, requiring alternative detectors to provide the same function and performance. Our alternative approach is one consisting of a thinly-coated 10B flat-panel ionization chamber neutron detector that can be deployed as a direct drop-in replacement for current RPM 3He detectors. The uniqueness of our approach in providing a large-area detector is in the simplicity of construction, scalability of the unit cell detector, ease of adaptability to a variety of applications and low cost. Currently, Rapiscan Laboratories and Helicon Thin Film Systems have designed and developed an operational 100 cm2 multi-layer prototype 10BB-based ionization chamber.

Random Initialisation of the Spectral Variables: an Alternate Approach for Initiating Multivariate Curve Resolution Alternating Least Square (MCR-ALS) Analysis.

PubMed

Kumar, Keshav

2017-11-01

Multivariate curve resolution alternating least square (MCR-ALS) analysis is the most commonly used curve resolution technique. The MCR-ALS model is fitted using the alternate least square (ALS) algorithm that needs initialisation of either contribution profiles or spectral profiles of each of the factor. The contribution profiles can be initialised using the evolve factor analysis; however, in principle, this approach requires that data must belong to the sequential process. The initialisation of the spectral profiles are usually carried out using the pure variable approach such as SIMPLISMA algorithm, this approach demands that each factor must have the pure variables in the data sets. Despite these limitations, the existing approaches have been quite a successful for initiating the MCR-ALS analysis. However, the present work proposes an alternate approach for the initialisation of the spectral variables by generating the random variables in the limits spanned by the maxima and minima of each spectral variable of the data set. The proposed approach does not require that there must be pure variables for each component of the multicomponent system or the concentration direction must follow the sequential process. The proposed approach is successfully validated using the excitation-emission matrix fluorescence data sets acquired for certain fluorophores with significant spectral overlap. The calculated contribution and spectral profiles of these fluorophores are found to correlate well with the experimental results. In summary, the present work proposes an alternate way to initiate the MCR-ALS analysis.

Identification of protein features encoded by alternative exons using Exon Ontology.

PubMed

Tranchevent, Léon-Charles; Aubé, Fabien; Dulaurier, Louis; Benoit-Pilven, Clara; Rey, Amandine; Poret, Arnaud; Chautard, Emilie; Mortada, Hussein; Desmet, François-Olivier; Chakrama, Fatima Zahra; Moreno-Garcia, Maira Alejandra; Goillot, Evelyne; Janczarski, Stéphane; Mortreux, Franck; Bourgeois, Cyril F; Auboeuf, Didier

2017-06-01

Transcriptomic genome-wide analyses demonstrate massive variation of alternative splicing in many physiological and pathological situations. One major challenge is now to establish the biological contribution of alternative splicing variation in physiological- or pathological-associated cellular phenotypes. Toward this end, we developed a computational approach, named "Exon Ontology," based on terms corresponding to well-characterized protein features organized in an ontology tree. Exon Ontology is conceptually similar to Gene Ontology-based approaches but focuses on exon-encoded protein features instead of gene level functional annotations. Exon Ontology describes the protein features encoded by a selected list of exons and looks for potential Exon Ontology term enrichment. By applying this strategy to exons that are differentially spliced between epithelial and mesenchymal cells and after extensive experimental validation, we demonstrate that Exon Ontology provides support to discover specific protein features regulated by alternative splicing. We also show that Exon Ontology helps to unravel biological processes that depend on suites of coregulated alternative exons, as we uncovered a role of epithelial cell-enriched splicing factors in the AKT signaling pathway and of mesenchymal cell-enriched splicing factors in driving splicing events impacting on autophagy. Freely available on the web, Exon Ontology is the first computational resource that allows getting a quick insight into the protein features encoded by alternative exons and investigating whether coregulated exons contain the same biological information. © 2017 Tranchevent et al.; Published by Cold Spring Harbor Laboratory Press.

Fast methods to numerically integrate the Reynolds equation for gas fluid films

NASA Technical Reports Server (NTRS)

Dimofte, Florin

1992-01-01

The alternating direction implicit (ADI) method is adopted, modified, and applied to the Reynolds equation for thin, gas fluid films. An efficient code is developed to predict both the steady-state and dynamic performance of an aerodynamic journal bearing. An alternative approach is shown for hybrid journal gas bearings by using Liebmann's iterative solution (LIS) for elliptic partial differential equations. The results are compared with known design criteria from experimental data. The developed methods show good accuracy and very short computer running time in comparison with methods based on an inverting of a matrix. The computer codes need a small amount of memory and can be run on either personal computers or on mainframe systems.

An Interactive Multi-Model for Consensus on Climate Change

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kocarev, Ljupco

This project purports to develop a new scheme for forming consensus among alternative climate models, that give widely divergent projections as to the details of climate change, that is more intelligent than simply averaging the model outputs, or averaging with ex post facto weighting factors. The method under development effectively allows models to assimilate data from one another in run time with weights that are chosen in an adaptive training phase using 20th century data, so that the models synchronize with one another as well as with reality. An alternate approach that is being explored in parallel is the automatedmore » combination of equations from different models in an expert-system-like framework.« less

The regulatory acceptance of alternatives in the European Union.

PubMed

Warbrick, E Vicky; Evans, Peter F

2004-06-01

Recently, progress has been made toward the regulatory acceptance of replacements in the European Union (EU), particularly with the introduction of in vitro methods for the prediction of skin corrosivity, dermal penetration, phototoxicity and embryotoxicity. In vitro genotoxicity tests are well established, and testing for this endpoint can be completed without animals, provided that clear negative outcomes are obtained. Tiered approaches including in vitro tests can also be used to address skin and eye irritation endpoints. Reductions and/or refinements in animal use are being achieved following the replacement of the oral LD50 test with alternative methods and the adoption of reduced test packages for materials, such as closed-system intermediates and certain polymers. Furthermore, the use of a "read-across" approach has reduced animal testing. Substantial gains in refinement will also be made with the recent acceptance of the local lymph node assay for skin sensitisation and the development of an acute inhalation toxicity method that avoids lethality as the endpoint. For the future, under the proposed EU Registration, Evaluation and Authorisation of Chemicals (REACH) scheme, it is envisaged that, where suitable in vitro methods exist, these should be used to support registration of substances produced at up to ten tonnes per annum. This proposal can only accelerate the further development, validation and regulatory acceptance of such alternative methods.

Alternative Splicing as a Target for Cancer Treatment.

PubMed

Martinez-Montiel, Nancy; Rosas-Murrieta, Nora Hilda; Anaya Ruiz, Maricruz; Monjaraz-Guzman, Eduardo; Martinez-Contreras, Rebeca

2018-02-11

Alternative splicing is a key mechanism determinant for gene expression in metazoan. During alternative splicing, non-coding sequences are removed to generate different mature messenger RNAs due to a combination of sequence elements and cellular factors that contribute to splicing regulation. A different combination of splicing sites, exonic or intronic sequences, mutually exclusive exons or retained introns could be selected during alternative splicing to generate different mature mRNAs that could in turn produce distinct protein products. Alternative splicing is the main source of protein diversity responsible for 90% of human gene expression, and it has recently become a hallmark for cancer with a full potential as a prognostic and therapeutic tool. Currently, more than 15,000 alternative splicing events have been associated to different aspects of cancer biology, including cell proliferation and invasion, apoptosis resistance and susceptibility to different chemotherapeutic drugs. Here, we present well established and newly discovered splicing events that occur in different cancer-related genes, their modification by several approaches and the current status of key tools developed to target alternative splicing with diagnostic and therapeutic purposes.

High-throughput alternative splicing detection using dually constrained correspondence analysis (DCCA).

PubMed

Baty, Florent; Klingbiel, Dirk; Zappa, Francesco; Brutsche, Martin

2015-12-01

Alternative splicing is an important component of tumorigenesis. Recent advent of exon array technology enables the detection of alternative splicing at a genome-wide scale. The analysis of high-throughput alternative splicing is not yet standard and methodological developments are still needed. We propose a novel statistical approach-Dually Constrained Correspondence Analysis-for the detection of splicing changes in exon array data. Using this methodology, we investigated the genome-wide alteration of alternative splicing in patients with non-small cell lung cancer treated by bevacizumab/erlotinib. Splicing candidates reveal a series of genes related to carcinogenesis (SFTPB), cell adhesion (STAB2, PCDH15, HABP2), tumor aggressiveness (ARNTL2), apoptosis, proliferation and differentiation (PDE4D, FLT3, IL1R2), cell invasion (ETV1), as well as tumor growth (OLFM4, FGF14), tumor necrosis (AFF3) or tumor suppression (TUSC3, CSMD1, RHOBTB2, SERPINB5), with indication of known alternative splicing in a majority of genes. DCCA facilitates the identification of putative biologically relevant alternative splicing events in high-throughput exon array data. Copyright © 2015 Elsevier Inc. All rights reserved.

Male contraception.

PubMed

Chao, Jing; Page, Stephanie T; Anderson, Richard A

2014-08-01

Clear evidence shows that many men and women would welcome new male methods of contraception, but none have become available. The hormonal approach is based on suppression of gonadotropins and thus of testicular function and spermatogenesis, and has been investigated for several decades. This approach can achieve sufficient suppression of spermatogenesis for effective contraception in most men, but not all; the basis for these men responding insufficiently is unclear. Alternatively, the non-hormonal approach is based on identifying specific processes in sperm development, maturation and function. A range of targets has been identified in animal models, and targeted effectively. This approach, however, remains in the pre-clinical domain at present. There are, therefore, grounds for considering that safe, effective and reversible methods of contraception for men can be developed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Children's Questions and Science Teaching: An Alternative Approach. [and] Floating and Sinking: Some Teaching Suggestions. Learning in Science Project (Primary). Working Paper No. 117 [February 1984 and November 1983 Versions].

ERIC Educational Resources Information Center

Biddulph, Fred; Osborne, Roger

Two booklets were developed by the Learning in Science Project (Primary)--LISP(P)--to help teachers adopt an approach to primary science teaching which would enhance children's understanding of floating and sinking. Both booklets were designed to enable teachers to reconceptualize their teaching task from activity-driven, didactic teaching to…

Unsupervised classification of surface defects in wire rod production obtained by eddy current sensors.

PubMed

Saludes-Rodil, Sergio; Baeyens, Enrique; Rodríguez-Juan, Carlos P

2015-04-29

An unsupervised approach to classify surface defects in wire rod manufacturing is developed in this paper. The defects are extracted from an eddy current signal and classified using a clustering technique that uses the dynamic time warping distance as the dissimilarity measure. The new approach has been successfully tested using industrial data. It is shown that it outperforms other classification alternatives, such as the modified Fourier descriptors.

An Alternative Approach to Teaching Public Speaking

ERIC Educational Resources Information Center

Fetzer, Ronald C.

1977-01-01

Describes the visual image approach as an alternative method of public speaking instruction based on the principle that meaning is associated with the object that meaning represents. Presents a rationale, objectives, procedures and results of implementation of this approach. (MH)

A Systems Approach to the Physiology of Weightlessness

NASA Technical Reports Server (NTRS)

White, Ronald J.; Leonard, Joel I.; Rummel, John A.; Leach, Carolyn S.

1991-01-01

A systems approach to the unraveling of the complex response pattern of the human subjected to weightlessness is presented. The major goal of this research is to obtain an understanding of the role that each of the major components of the human system plays following the transition to and from space. The cornerstone of this approach is the utilization of a variety of mathematical models in order to pose and test alternative hypotheses concerned with the adaptation process. An integrated hypothesis for the human physiological response to weightlessness is developed.

Alternatives to relational databases in precision medicine: Comparison of NoSQL approaches for big data storage using supercomputers

NASA Astrophysics Data System (ADS)

Velazquez, Enrique Israel

Improvements in medical and genomic technologies have dramatically increased the production of electronic data over the last decade. As a result, data management is rapidly becoming a major determinant, and urgent challenge, for the development of Precision Medicine. Although successful data management is achievable using Relational Database Management Systems (RDBMS), exponential data growth is a significant contributor to failure scenarios. Growing amounts of data can also be observed in other sectors, such as economics and business, which, together with the previous facts, suggests that alternate database approaches (NoSQL) may soon be required for efficient storage and management of big databases. However, this hypothesis has been difficult to test in the Precision Medicine field since alternate database architectures are complex to assess and means to integrate heterogeneous electronic health records (EHR) with dynamic genomic data are not easily available. In this dissertation, we present a novel set of experiments for identifying NoSQL database approaches that enable effective data storage and management in Precision Medicine using patients' clinical and genomic information from the cancer genome atlas (TCGA). The first experiment draws on performance and scalability from biologically meaningful queries with differing complexity and database sizes. The second experiment measures performance and scalability in database updates without schema changes. The third experiment assesses performance and scalability in database updates with schema modifications due dynamic data. We have identified two NoSQL approach, based on Cassandra and Redis, which seems to be the ideal database management systems for our precision medicine queries in terms of performance and scalability. We present NoSQL approaches and show how they can be used to manage clinical and genomic big data. Our research is relevant to the public health since we are focusing on one of the main challenges to the development of Precision Medicine and, consequently, investigating a potential solution to the progressively increasing demands on health care.

Novel and emerging nonpositive airway pressure therapies for sleep apnea.

PubMed

Park, John G; Morgenthaler, Timothy M; Gay, Peter C

2013-12-01

CPAP therapy has remained the standard of care for the treatment of sleep apnea for nearly 4 decades. Its overall effectiveness, however, has been limited by incomplete adherence despite many efforts to improve comfort. Conventional alternative therapies include oral appliances and upper airway surgeries. Recently, several innovative alternatives to CPAP have been developed. These novel approaches include means to increase arousal thresholds, electrical nerve stimulation, oral vacuum devices, and nasal expiratory resistive devices. We will review the physiologic mechanisms and the current evidence for these novel treatments.

Diatom Milking: A Review and New Approaches

PubMed Central

Vinayak, Vandana; Manoylov, Kalina M.; Gateau, Hélène; Blanckaert, Vincent; Hérault, Josiane; Pencréac’h, Gaëlle; Marchand, Justine; Gordon, Richard; Schoefs, Benoît

2015-01-01

The rise of human populations and the growth of cities contribute to the depletion of natural resources, increase their cost, and create potential climatic changes. To overcome difficulties in supplying populations and reducing the resource cost, a search for alternative pharmaceutical, nanotechnology, and energy sources has begun. Among the alternative sources, microalgae are the most promising because they use carbon dioxide (CO2) to produce biomass and/or valuable compounds. Once produced, the biomass is ordinarily harvested and processed (downstream program). Drying, grinding, and extraction steps are destructive to the microalgal biomass that then needs to be renewed. The extraction and purification processes generate organic wastes and require substantial energy inputs. Altogether, it is urgent to develop alternative downstream processes. Among the possibilities, milking invokes the concept that the extraction should not kill the algal cells. Therefore, it does not require growing the algae anew. In this review, we discuss research on milking of diatoms. The main themes are (a) development of alternative methods to extract and harvest high added value compounds; (b) design of photobioreactors; (c) biodiversity and (d) stress physiology, illustrated with original results dealing with oleaginous diatoms. PMID:25939034

Advances in EPA’s Rapid Exposure and Dosimetry Project (Interagency Alternatives Assessment Webinar)

EPA Science Inventory

Estimates of human and ecological exposures are required as critical input to risk-based prioritization and screening of chemicals. The CSS Rapid Exposure and Dosimetry project seeks to develop the data, tools, and evaluation approaches required to generate rapid and scientifical...

A School Finance Computer Simulation Model

ERIC Educational Resources Information Center

Boardman, Gerald R.

1974-01-01

Presents a description of the computer simulation model developed by the National Educational Finance Project for use by States in planning and evaluating alternative approaches for State support programs. Provides a general introduction to the model, a program operation overview, a sample run, and some conclusions. (Author/WM)

Utilizing soil polypedons to improve model performance for digital soil mapping

USDA-ARS?s Scientific Manuscript database

Most digital soil mapping approaches that use point data to develop relationships with covariate data intersect sample locations with one raster pixel regardless of pixel size. Resulting models are subject to spurious values in covariate data which may limit model performance. An alternative approac...

Components of Individual Differences in Human Intelligence. Final Report.

ERIC Educational Resources Information Center

Sternberg, Robert J.

This final report reviews the main theoretical and empirical developments concerning components of individual differences in human intelligence. The report is divided into three main sections. The first briefly reviews alternative approaches to understanding the nature of intelligence. The second provides the proposed componential metatheory, a…

Validation of Screening Assays for Developmental Toxicity: An Exposure-Based Approach

EPA Science Inventory

There continue to be widespread efforts to develop assay methods for developmental toxicity that are shorter than the traditional Segment 2 study and use fewer or no animals. As with any alternative test method, novel developmental toxicity assays must be validated by evaluating ...

Evidence-Based Instructional Leadership in Community Colleges: A Conceptual Approach

ERIC Educational Resources Information Center

Burke, Kenneth M.

2014-01-01

Instructional leadership remains a complicated and debated issue for education. In fact, traditional theories of leadership from within both education and the organizational sciences increasingly face criticism. Drawing from ideas applicable to differentiated contexts of learning, this article develops an alternative model of instructional…

A Simple Approach To Assessing Copper Pitting Corrosion Tendenices and Developing Control Strategies

EPA Science Inventory

The objective of this research was to assess the effectiveness of a simple pipe loop system and protocol to predict localized corrosion, and to assess treatment alternatives for a drinking water that has been associated with customer complaints of pinhole leaks.

Development and evaluation of alternative approaches for exposure assessment of multiple air pollutants in Atlanta, Georgia

EPA Science Inventory

Measurements from central site (CS) monitors are often used as estimates of exposure in air pollution epidemiological studies. As these measurements are typically limited in their spatiotemporal resolution, true exposure variability within a population is often obscured, leading ...

Corporal Punishment in Schools: Myths, Problems and Alternatives.

ERIC Educational Resources Information Center

Dubanoski, Richard A.; And Others

1983-01-01

The paper examines common myths about corporal punishment (e.g., that it builds character), discusses potential problems from its use (such as loss of self-esteem and development of counterproductive behavior), and describes three positive approaches to discipline (behavior modification, social learning, and communication skills training).…

Will SOAR Really Help Organization Development Soar?

ERIC Educational Resources Information Center

McLean, Gary N.

2017-01-01

This article was written in response to the editor's invitation to provide an alternative perspective to Zarestky and Cole's article in this same issue. While appreciating the perspective provided, I question the assumption that SOAR (strengths, opportunities, aspirations, results) as an approach to strategic planning will strengthen organization…

Recovering Parameters of Johnson's SB Distribution

Treesearch

Bernard R. Parresol

2003-01-01

A new parameter recovery model for Johnson's SB distribution is developed. This latest alternative approach permits recovery of the range and both shape parameters. Previous models recovered only the two shape parameters. Also, a simple procedure for estimating the distribution minimum from sample values is presented. The new methodology...

Development of a Database for Drilled SHAft Foundation Testing (DSHAFT) : tech transfer summary.

DOT National Transportation Integrated Search

2012-06-01

Drilled shafts have been used in the US for more than 100 years in bridges and buildings as a deep foundation alternative. For many of these applications, the drilled shafts were designed using the Working Stress Design (WSD) approach. Even though WS...

On the engineering of crucial software

NASA Technical Reports Server (NTRS)

Pratt, T. W.; Knight, J. C.; Gregory, S. T.

1983-01-01

The various aspects of the conventional software development cycle are examined. This cycle was the basis of the augmented approach contained in the original grant proposal. This cycle was found inadequate for crucial software development, and the justification for this opinion is presented. Several possible enhancements to the conventional software cycle are discussed. Software fault tolerance, a possible enhancement of major importance, is discussed separately. Formal verification using mathematical proof is considered. Automatic programming is a radical alternative to the conventional cycle and is discussed. Recommendations for a comprehensive approach are presented, and various experiments which could be conducted in AIRLAB are described.

The Picture Exchange Communication System.

PubMed

Bondy, A; Frost, L

2001-10-01

The Picture Exchange Communication System (PECS) is an alternative/augmentative communication system that was developed to teach functional communication to children with limited speech. The approach is unique in that it teaches children to initiate communicative interactions within a social framework. This article describes the advantages to implementing PECS over traditional approaches. The PECS training protocol is described wherein children are taught to exchange a single picture for a desired item and eventually to construct picture-based sentences and use a variety of attributes in their requests. The relationship of PECS's implementation to the development of speech in previously nonvocal students is reviewed.

Spacelab user implementation assessment study (software requirements analysis). Volume 1: Executive study

NASA Technical Reports Server (NTRS)

1976-01-01

The primary objective of this study was to develop an integrated approach for the development, implementation, and utilization of all software that is required to efficiently and cost-effectively support advanced technology laboratory flight and ground operations. It was recognized that certain aspects of the operations would be mandatory computerized services; computerization of other aspects would be optional. Thus, the analyses encompassed not only alternate computer utilization and implementations but trade studies of the programmatic effects of non-computerized versus computerized approaches to the operations. A general overview of the study is presented.

Programmable calculator as a data system controller

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barth, A.W.; Strasburg, A.C.

Digital data techniques are in common use for analysis of analog information obtained in various tests, and systems have been developed which use a minicomputer as the central controller and data processor. Now, microprocessors allow new design approaches at considerably less cost. This report outlines an approach to system design based on the use of a programmable calculator as the data system controller. A block diagram of the calculator-controlled data system is shown. It was found that the programmable calculator provides a viable alternative to minicomputers or microprocessors for the development laboratory requiring digital data processing. 3 figures. (RWR)

Are Conventional Farmers Conventional? Analysis of the Environmental Orientations of Conventional New Zealand Farmers

ERIC Educational Resources Information Center

Fairweather, John R.; Hunt, Lesley M.; Rosin, Chris J.; Campbell, Hugh R.

2009-01-01

Within the political economy of agriculture and agrofood literatures there are examples of approaches that reject simple dichotomies between alternatives and the mainstream. In line with such approaches, we challenge the assumption that alternative agriculture, and its attendant improved environmental practices, alternative management styles, less…

Appreciative inquiry in medical education.

PubMed

Sandars, John; Murdoch-Eaton, Deborah

2017-02-01

The practice of medicine, and also medical education, typically adopts a problem-solving approach to identify "what is going wrong" with a situation. However, an alternative is Appreciative Inquiry (AI), which adopts a positive and strengths-based approach to identify "what is going well" with a situation. The AI approach can be used for the development and enhancement of the potential of both individuals and organizations. An essential aspect of the AI approach is the generative process, in which a new situation is envisioned and both individual and collective strengths are mobilized to make changes to achieve the valued future situation. The AI approach has been widely used in the world of business and general education, but is has an exciting potential for medical education, including curriculum development, faculty development, supporting learners through academic advising and mentoring, but also for enhancing the teaching and learning of both individuals and groups. This AMEE Guide describes the core principles of AI and their practical application in medical education.

An alternative approach for computing seismic response with accidental eccentricity

NASA Astrophysics Data System (ADS)

Fan, Xuanhua; Yin, Jiacong; Sun, Shuli; Chen, Pu

2014-09-01

Accidental eccentricity is a non-standard assumption for seismic design of tall buildings. Taking it into consideration requires reanalysis of seismic resistance, which requires either time consuming computation of natural vibration of eccentric structures or finding a static displacement solution by applying an approximated equivalent torsional moment for each eccentric case. This study proposes an alternative modal response spectrum analysis (MRSA) approach to calculate seismic responses with accidental eccentricity. The proposed approach, called the Rayleigh Ritz Projection-MRSA (RRP-MRSA), is developed based on MRSA and two strategies: (a) a RRP method to obtain a fast calculation of approximate modes of eccentric structures; and (b) an approach to assemble mass matrices of eccentric structures. The efficiency of RRP-MRSA is tested via engineering examples and compared with the standard MRSA (ST-MRSA) and one approximate method, i.e., the equivalent torsional moment hybrid MRSA (ETM-MRSA). Numerical results show that RRP-MRSA not only achieves almost the same precision as ST-MRSA, and is much better than ETM-MRSA, but is also more economical. Thus, RRP-MRSA can be in place of current accidental eccentricity computations in seismic design.

What Undergraduates Misunderstand about Stem Cell Research

NASA Astrophysics Data System (ADS)

Halverson, Kristy Lynn; Freyermuth, Sharyn K.; Siegel, Marcelle A.; Clark, Catharine G.

2010-11-01

As biotechnology-related scientific advances, such as stem cell research (SCR), are increasingly permeating the popular media, it has become ever more important to understand students' ideas about this issue. Very few studies have investigated learners' ideas about biotechnology. Our study was designed to understand the types of alternative conceptions students hold concerning SCR. The qualitative research design allowed us to examine college students' understandings about stem cells and SCR. More specifically, we addressed the following questions: How can alternative conceptions about stem cell topics be categorized? What types of alternative conceptions are most common? Participants included 132 students enrolled in a biotechnology course that focused on the scientific background of biotechnology applications relevant to citizens. In this study, we used an inductive approach to develop a taxonomy of alternative ideas about SCR by analyzing student responses to multiple open-ended data sources. We identified five categories of conceptions: alternative conceptions about what, alternative conceptions about how, alternative conceptions about medical potential, terminology confusion, and political and legal alternative conceptions. In order to improve instruction, it is important to understand students' ideas when entering the classroom. Our findings highlight a need to teach how science can be applied to societal issues and improve science literacy and citizenship.

[THE PERSPECTIVES OF DEVELOPMENT OF HEALTH CARE OF THE RUSSIAN FEDERATION].

PubMed

Schepin, O P; Korotkikh, R V

2015-01-01

The article considers actual conditions and characteristics of reformation of health care of Russia. The comparison is applied to such sectoral aspects as decentralization, medical care accessibility, public sector of health care, health of healthy population, resources distribution, medical insurance, paid medical services, etc. The comprehensive approach is proposed to resolving problems of national health care and alternatives of main direction of sectoral development.

Development of a basal area growth system for maritime pine in northwestern Spain using the generalized algebraic difference approach

Treesearch

Marcos Barrio Anta; Fernando Castedo Dorado; Ulises Dieguez-Aranda; Juan G. Alvarez Gonzalez; Bernard R. Parresol; Roque Rodriguez Soalleiro

2006-01-01

A basal area growth system for single-species, even-aged maritime pine (Pinus pinaster Ait.) stands in Galicia (northwestern Spain) was developed from data of 212 plots measured between one and four times. Six dynamic equations were considered for analysis, and both numerical and graphical methods were used to compare alternative models. The double...

Human Vaccines & Immunotherapeutics: News

PubMed Central

Riedmann, Eva M

2013-01-01

Vaccinating boys against HPV to reduce cancer rates across the sexes New melanoma vaccine contains natural product from marine sponges Impact of Hib conjugate vaccines in developing countries Electronic Health Records to keep track of immunization status Pregnant women urged to get whooping cough vaccination New nano-coating developed to preserve vaccines Alternative approach to creating a universal flu vaccine New modular vaccine design: MAPS technology PMID:24051387

Development of an expedient intramolecular Pauson-Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center.

PubMed

Shi, Li-Li; Shen, Hong-Juan; Fang, Li-Chao; Huang, Jun; Li, Chuang-Chuang; Yang, Zhen

2013-10-09

Stereoselective synthesis of the trans-decalin subunit with a defined C1 quaternary chiral center has been achieved by the Pauson-Khand reaction (PKR) as a key step. The developed chemistry offers an alternative to the IMDA reaction that has been used for the syntheses of trans-decalin based biologically active natural products.

An approach for the anticipatory and participatory management of current and future flood risks

NASA Astrophysics Data System (ADS)

Luther, J.

2012-04-01

Despite the fact that many measures to attenuate flood hazards and reduce vulnerabilities are being implemented, adverse effects of floods are ever-increasing in most parts of the world. On the one hand this holds true for economically and/or demographically growing regions. On the other hand this applies also to areas that face population shrinkage and economic problems. Such flood risks occur in human-environment systems and are subject to dynamics caused by a number of drivers such as climate change, land-use changes, and others. Many drivers evolve slowly over time or show time-lag effects and long return periods. Moreover, certain decisions may determine the control actions of the following decades. At present, current flood risks are mostly determined based on historic developments and the ex post analysis of flood events. Approaches that look at the future dynamics of both hazards and vulnerable elements ex ante in an integrated manner are rare. Instead, future hazard scenarios are often just overlaid with current socio-economic data, which poses a strong inconsistency. Usually the focus lies on rather short-term, specific or local problems. But many developments and measures show their effects only after long time periods and when considering the whole catchment area. This calls for a holistic and long-term view into the future and implies the challenge of dealing with many uncertainties due to the system's complexity. In order to anticipate and react to these developments, this contribution suggests developing a flexible, yet holistic approach to design, analyse and evaluate alternative futures of such human-environment systems. These futures follow a scenario understanding that considers both specific (current) factor constellations as well as consistent assumptions on autonomous developments (so-called development frameworks) and potentials for control (strategic alternatives) of the interacting entities that influence flood risk. Different scenario concepts and the application of respective techniques are thus reviewed and incorporated with regard to their suitability for an integrated management of current and future flood risks. In particular, "hybrid scenarios" with qualitative and quantitative components represented by nested models as well as assumptions across different spatiotemporal scales, respectively, are suggested for dealing with the uncertainties when assessing flood risks throughout a system's possible evolution. The (initially top-down developed) approach and its components will be briefly presented. These "scenario products" could later serve as a stimulus for discussions that bring together different actors and enhance - and eventually legitimise - the scenarios further in a "scenario process": (1) A first step is the conceptualisation of a flood risk system following the SPRC-model. Its physical geographical and anthropogenic factors may either be subject to autonomous trends, target-oriented control, or facultative system behaviour (e.g. dike breaches). With this concept, the integration of different processes and scales is aspired. (2) Secondly, it is conceptually shown how the risk cascade for present and future states of the flood risk system can be calculated based on coupled models ranging from climate change projections to a damage simulation models. (3) Thirdly, ways to develop socioeconomic storylines for the development frameworks and guiding principles for the strategic alternatives are presented and the futures are combined. This involves making plausible and consistent assumptions for many system factors and their drivers and finding ways to harmonise existing data for the same areas and time steps. (4) Fourthly, selected futures can be analysed and evaluated ex ante applying the coupled models of the second step to derive the emerging flood risks. The evaluation addresses, amongst other aspects, the identification of (i) the sensitivity of all scenarios against the current strategic alternative; (ii) the resulting risks when applying different strategic alternatives against one selected scenario; (iii) the efficiency (as cost-effectiveness) and robustness of one selected strategic alternative against the different scenarios; and (iv) the model uncertainty, for example caused by different climate downscaling methods. It is of growing importance to place any scenario/simulation results in a societal or even individual context and confront them with the perspectives of the people potentially affected. Only this yields a holistic picture and may lead to sustainable, comprehensible decisions. The approach is partly exemplified with research conducted in Saxony (Germany) and the Elbe River catchment in Central Europe and concentrates on river or plain floods, neglecting water quality issues.

Low dose CT reconstruction via L1 norm dictionary learning using alternating minimization algorithm and balancing principle.

PubMed

Wu, Junfeng; Dai, Fang; Hu, Gang; Mou, Xuanqin

2018-04-18

Excessive radiation exposure in computed tomography (CT) scans increases the chance of developing cancer and has become a major clinical concern. Recently, statistical iterative reconstruction (SIR) with l0-norm dictionary learning regularization has been developed to reconstruct CT images from the low dose and few-view dataset in order to reduce radiation dose. Nonetheless, the sparse regularization term adopted in this approach is l0-norm, which cannot guarantee the global convergence of the proposed algorithm. To address this problem, in this study we introduced the l1-norm dictionary learning penalty into SIR framework for low dose CT image reconstruction, and developed an alternating minimization algorithm to minimize the associated objective function, which transforms CT image reconstruction problem into a sparse coding subproblem and an image updating subproblem. During the image updating process, an efficient model function approach based on balancing principle is applied to choose the regularization parameters. The proposed alternating minimization algorithm was evaluated first using real projection data of a sheep lung CT perfusion and then using numerical simulation based on sheep lung CT image and chest image. Both visual assessment and quantitative comparison using terms of root mean square error (RMSE) and structural similarity (SSIM) index demonstrated that the new image reconstruction algorithm yielded similar performance with l0-norm dictionary learning penalty and outperformed the conventional filtered backprojection (FBP) and total variation (TV) minimization algorithms.

Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Tools.

PubMed

Griesinger, Claudius; Desprez, Bertrand; Coecke, Sandra; Casey, Warren; Zuang, Valérie

This chapter explores the concepts, processes, tools and challenges relating to the validation of alternative methods for toxicity and safety testing. In general terms, validation is the process of assessing the appropriateness and usefulness of a tool for its intended purpose. Validation is routinely used in various contexts in science, technology, the manufacturing and services sectors. It serves to assess the fitness-for-purpose of devices, systems, software up to entire methodologies. In the area of toxicity testing, validation plays an indispensable role: "alternative approaches" are increasingly replacing animal models as predictive tools and it needs to be demonstrated that these novel methods are fit for purpose. Alternative approaches include in vitro test methods, non-testing approaches such as predictive computer models up to entire testing and assessment strategies composed of method suites, data sources and decision-aiding tools. Data generated with alternative approaches are ultimately used for decision-making on public health and the protection of the environment. It is therefore essential that the underlying methods and methodologies are thoroughly characterised, assessed and transparently documented through validation studies involving impartial actors. Importantly, validation serves as a filter to ensure that only test methods able to produce data that help to address legislative requirements (e.g. EU's REACH legislation) are accepted as official testing tools and, owing to the globalisation of markets, recognised on international level (e.g. through inclusion in OECD test guidelines). Since validation creates a credible and transparent evidence base on test methods, it provides a quality stamp, supporting companies developing and marketing alternative methods and creating considerable business opportunities. Validation of alternative methods is conducted through scientific studies assessing two key hypotheses, reliability and relevance of the test method for a given purpose. Relevance encapsulates the scientific basis of the test method, its capacity to predict adverse effects in the "target system" (i.e. human health or the environment) as well as its applicability for the intended purpose. In this chapter we focus on the validation of non-animal in vitro alternative testing methods and review the concepts, challenges, processes and tools fundamental to the validation of in vitro methods intended for hazard testing of chemicals. We explore major challenges and peculiarities of validation in this area. Based on the notion that validation per se is a scientific endeavour that needs to adhere to key scientific principles, namely objectivity and appropriate choice of methodology, we examine basic aspects of study design and management, and provide illustrations of statistical approaches to describe predictive performance of validated test methods as well as their reliability.

Alternative Significant Contribution Approaches Evaluated

EPA Pesticide Factsheets

This Technical Support Document (TSD) discusses alternative approaches that EPA evaluated for defining emissions that constitute each upwind state’s significant contribution to nonattainment and interference with maintenance downwind.

Review Article: Celiac Disease, New Approaches to Therapy

PubMed Central

Rashtak, Shahrooz; Murray, Joseph A

2014-01-01

STRUCTURED SUMMARY Background Celiac disease is managed by life-long gluten withdrawal from the diet. However strict adherence to a gluten-free diet is difficult and is not always effective. Novel therapeutic approaches are needed to supplement or even replace the dietary treatment. Aims To review recent advances in new therapeutic options for celiac disease. Methods A literature search was performed on MEDLINE, EMBASE, Web of Science, Scopus, DDW.org and ClinicalTrial.gov for English articles and abstracts. The search terms used include but not limited to “Celiac disease”, “new”, “novel”, Advances”, “alternatives” and “Drug therapy”. The cited articles were selected based on the relevancy to the review objective. Results Several new therapeutic approaches for celiac disease are currently under development by targeting its underlying pathogenesis. Alternative therapies range from reproduction of harmless wheat strains to immunomodulatory approaches. Some of these therapies such as enzymatic cleavage of gluten and permeability inhibitors have shown promise in clinical studies. Conclusion Gluten-free diet is still the only practical treatment for patients with celiac disease. Novel strategies provide promise of alternative adjunctive approaches to diet restriction alone for patients with this disorder. PMID:22324389

Trust-Based Security Level Evaluation Using Bayesian Belief Networks

NASA Astrophysics Data System (ADS)

Houmb, Siv Hilde; Ray, Indrakshi; Ray, Indrajit; Chakraborty, Sudip

Security is not merely about technical solutions and patching vulnerabilities. Security is about trade-offs and adhering to realistic security needs, employed to support core business processes. Also, modern systems are subject to a highly competitive market, often demanding rapid development cycles, short life-time, short time-to-market, and small budgets. Security evaluation standards, such as ISO 14508 Common Criteria and ISO/IEC 27002, are not adequate for evaluating the security of many modern systems for resource limitations, time-to-market, and other constraints. Towards this end, we propose an alternative time and cost effective approach for evaluating the security level of a security solution, system or part thereof. Our approach relies on collecting information from different sources, who are trusted to varying degrees, and on using a trust measure to aggregate available information when deriving security level. Our approach is quantitative and implemented as a Bayesian Belief Network (BBN) topology, allowing us to reason over uncertain information and seemingly aggregating disparate information. We illustrate our approach by deriving the security level of two alternative Denial of Service (DoS) solutions. Our approach can also be used in the context of security solution trade-off analysis.

Specialized ADR To Settle Faculty Employment Disputes.

ERIC Educational Resources Information Center

DiNardo, Lawrence C.; Sherrill, John A.; Palmer, Anna R.

2001-01-01

Presents an innovative approach to resolution of faculty employment disputes at institutions of higher education. Discusses the framework in which faculty employment issues arise, the current state of alternative dispute resolution (ADR) as it is relevant to employment disputes, and the substantial benefits which could be achieved by developing a…

Using Rasch Analysis to Inform Rating Scale Development

ERIC Educational Resources Information Center

Van Zile-Tamsen, Carol

2017-01-01

The use of surveys, questionnaires, and rating scales to measure important outcomes in higher education is pervasive, but reliability and validity information is often based on problematic Classical Test Theory approaches. Rasch Analysis, based on Item Response Theory, provides a better alternative for examining the psychometric quality of rating…

The Latent Variable Approach as Applied to Transitive Reasoning

ERIC Educational Resources Information Center

Bouwmeester, Samantha; Vermunt, Jeroen K.; Sijtsma, Klaas

2012-01-01

We discuss the limitations of hypothesis testing using (quasi-) experiments in the study of cognitive development and suggest latent variable modeling as a viable alternative to experimentation. Latent variable models allow testing a theory as a whole, incorporating individual differences with respect to developmental processes or abilities in the…

Opportunities for Automation of Student Aid Processing in Postsecondary Institutions.

ERIC Educational Resources Information Center

St. John, Edward P.

1986-01-01

An overview of the options and opportunities postsecondary institutions should consider when developing plans for student aid automation is provided. The role of automation in the financial aid office, interfaces with institutional and external systems, alternative approaches to automation, and the need for an institutional strategy for automation…

Using Conceptual Change Research To Reason about Curriculum. Research Series No. 195.

ERIC Educational Resources Information Center

Berkheimer, Glenn D.; And Others

During the last 10 years, cognitive science researchers have produced research findings that have great potential for increasing students' understanding of science. However, commercial publishers continue to produce textbooks and teacher's guides in traditional ways. This project developed a prototype unit which used an alternative approach to…

Transformative Science Education through Action Research and Self-Study Practices

ERIC Educational Resources Information Center

Calderon, Olga

2014-01-01

The research studies human emotions through diverse methods and theoretical lenses. My intention in using this approach is to provide alternative ways of perceiving and interpreting emotions being experienced in the moment of arousal. Emotions are fundamental in human interactions because they are essential in the development of effective…

Regression Discontinuity Design: A Guide for Strengthening Causal Inference in HRD

ERIC Educational Resources Information Center

Chambers, Silvana

2016-01-01

Purpose: Regression discontinuity (RD) design is a sophisticated quasi-experimental approach used for inferring causal relationships and estimating treatment effects. This paper aims to educate human resource development (HRD) researchers and practitioners on the implementation of RD design as an ethical alternative for making causal claims about…

Identifying drought adaptive traits in upland cotton using a proximal sensing cart for high-throughput phenotyping

USDA-ARS?s Scientific Manuscript database

Field-based high-throughput phenotyping is an emerging approach to characterize difficult, time-sensitive plant traits in relevant growing conditions. Proximal sensing carts have been developed as an alternative platform to more costly high-clearance tractors for phenotyping dynamic traits in the fi...

Radical Literary Education: A Classroom Experiment with Wordsworth's "Ode."

ERIC Educational Resources Information Center

Robinson, Jeffrey C.

Using a college course on William Wordsworth's "Ode: Intimations of Immortality from Recollections of Early Childhood" as a case study, this book presents an alternative approach to teaching poetry. Divided into seven sections with 19 chapters, the book describes how students can develop and exercise an historical imagination in the…

Word Identification in Reading and the Promise of Subsymbolic Psycholinguistics.

ERIC Educational Resources Information Center

Van Orden, Guy C.; And Others

1990-01-01

It is argued that dual-process theory has misconstrued the correspondence between words' spelling and their phonology. A subsymbolic alternative to dual-processing theory is presented that includes a clear role for the process of phonologic coding. The subsymbolic approach is developed around a covariant learning hypothesis. (SLD)

Integrating Cognitive Science and Technology Improves Learning in a STEM Classroom

ERIC Educational Resources Information Center

Butler, Andrew C.; Marsh, Elizabeth J.; Slavinsky, J. P.; Baraniuk, Richard G.

2014-01-01

The most effective educational interventions often face significant barriers to widespread implementation because they are highly specific, resource intense, and/or comprehensive. We argue for an alternative approach to improving education: leveraging technology and cognitive science to develop interventions that generalize, scale, and can be…

The Confidence Model: An Alternative Approach to Alleviating Communication Apprehension.

ERIC Educational Resources Information Center

Watson, Arden K.

Recognizing that each student is different in terms of communication apprehension and needed skills, the confidence model attempts to provide instruction in anxiety reduction and skill development, combining the features of both the behavior therapy and the rhetoritherapy theories of communication apprehension. The rational emotive therapy used in…

Economic Risk Analysis of Agricultural Tillage Systems Using the SMART Stochastic Efficiency Software Package

USDA-ARS?s Scientific Manuscript database

Recently, a variant of stochastic dominance called stochastic efficiency with respect to a function (SERF) has been developed and applied. Unlike traditional stochastic dominance approaches, SERF uses the concept of certainty equivalents (CEs) to rank a set of risk-efficient alternatives instead of...

Engineering yeasts for xylose metabolism

Treesearch

Thomas W. Jeffries

2006-01-01

Technologies for the production of alternative fuels are receiving increased attention owing to concerns over the rising cost of petrol and global warming. One such technology under development is the use of yeasts for the commercial fermentation of xylose to ethanol. Several approaches have been employed to engineer xylose metabolism. These involve modeling, flux...

Group Motivational Interviewing in Schools: Development of a Health Promotion Intervention

ERIC Educational Resources Information Center

Hawkins, Jemma L.; Bravo, Paulina; Gobat, Nina; Rollnick, Stephen; Jerzembek, Gabrielle; Whitehead, Sarah; Chanon, Sue; Kelson, Mark; Adams, Orla; Murphy, Simon

2016-01-01

Objective: In the light of the shortcomings of curriculum-based health promotion in secondary schools, group motivational interviewing provides a potential alternative approach. This two-phase study set out to establish the key components, feasibility and acceptability of a group motivational interviewing intervention, focused on alcohol…

Community College Roles in Teacher Education: Current Approaches and Future Possibilities.

ERIC Educational Resources Information Center

Townsend, Barbara K.; Ignash, Jan M, ED.

2003-01-01

Examines the current role of community colleges in pre-service and in-service teacher education, including the development of the associate of arts degree in teacher education, the community college baccalaureate in teacher education, and alternative certification programs. Discusses factors influencing future trends and predictions about the…

Engineering Sustainable Engineers through the Undergraduate Experience

ERIC Educational Resources Information Center

Weatherton, Yvette Pearson; Sattler, Melanie; Mattingly, Stephen; Chen, Victoria; Rogers, Jamie; Dennis, Brian

2012-01-01

In order to meet the challenges of sustainable development, our approach to education must be modified to equip students to evaluate alternatives and devise solutions that meet multi-faceted requirements. In 2009, faculty in the Departments of Civil, Industrial and Mechanical Engineering at the University of Texas at Arlington began implementation…

Understanding "Price" and the Environment: Exploring Upper Secondary Students' Conceptual Development

ERIC Educational Resources Information Center

Ignell, Caroline; Davies, Peter; Lundholm, Cecilia

2017-01-01

Purpose: To explore changes in upper secondary students' conceptions of environmental issues in how prices are determined and how they should be determined. Design: The study uses an "alternative frameworks" conceptual change approach to examine change in the conceptions of fifteen business and economic students. Students were asked…

Inventory and assessment of foliar natural enemies of the soybean aphid (Hemiptera: Aphididae) in South Dakota

USDA-ARS?s Scientific Manuscript database

Soybean aphid (Aphis glycines Matsumura) (Hemiptera: Aphididae) is a major pest of soybean in northern production regions of North America, and insecticides have been the primary management approach while alternative methods are developed. Knowledge of arthropod natural enemies and their impact on ...

Alternatives for Man and Environment, Revised Curriculum.

ERIC Educational Resources Information Center

Miami-Dade Junior Coll., FL.

A one-year general education course entitled "Man and Environment" has been developed at Miami-Dade Junior College, Florida. Basic framework for the course was built on the premise that an interdisciplinary, module-structured course represents one of the better approaches to planning environmental education curriculum. Material for the…

Developing Students' Mathematical Skills Involving Order of Operations

ERIC Educational Resources Information Center

Ali Rahman, Ernna Sukinnah; Shahrill, Masitah; Abbas, Nor Arifahwati; Tan, Abby

2017-01-01

This small-scale action research study examines the students' ability in using their mathematical skills when performing order of operations in numerical expressions. In this study, the "hierarchy-of-operators triangle" by Ameis (2011) was introduced as an alternative BODMAS approach to help students in gaining a better understanding…

Evaluation of light attraction for the stored-product psocids, Liposcelis entomophila, L. paeta, and L. brunnea

USDA-ARS?s Scientific Manuscript database

Psocids have become global pests of stored commodities as they can cause considerable economic losses, and they are difficult to control because they have developed resistance to many chemical insecticides. Therefore, it is crucial to investigate alternative integrated pest management (IPM) approach...

Dynamic Assessment in Combination with Video Interaction Guidance in Preschool Education

ERIC Educational Resources Information Center

Krejcová, Kristýna

2015-01-01

Dynamic assessment represents an alternative diagnostic approach focused on the revelation of the tested persons' learning potential. The learning potential is observed via the emphasis on the achievement process. It aims at meaningful connection with the intervention that immediately applies diagnostic findings to support the development of an…

Competence Challenges of Demand-Led Agricultural Research and Extension in Uganda

ERIC Educational Resources Information Center

Kibwika, P.; Wals, A. E. J.; Nassuna-Musoke, M. G.

2009-01-01

Governments and development agencies in Sub-Saharan Africa are experimenting alternative approaches within the innovation systems paradigm to enhance relevance of agricultural research and extension to the poverty eradication agenda. Uganda, for example, has recently shifted from the supply driven to demand-led agricultural research and extension.…

Inclusion of Alternative and Complementary Therapies in CACREP Training Programs: A Survey

ERIC Educational Resources Information Center

Lumadue, Christine A.; Munk, Melanie; Wooten, H. Ray

2005-01-01

Given a heightened focus within the mental health profession on creative, complementary, and alternative practices, the authors surveyed CACREP programs with respect to their inclusion of such approaches in counselor training. For the purpose of this study, these approaches were designated as complementary and alternative methods (CAM) and defined…

Conference on alternatives for pollution control from coal-fired low emission sources, Plzen, Czech Republic. Plzen Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-07-01

The Conference on Alternatives for Pollution Control from Coal-Fired Emission Sources presented cost-effective approaches for pollution control of low emission sources (LES). It also identified policies and strategies for implementation of pollution control measures at the local level. Plzen, Czech Republic, was chosen as the conference site to show participants first hand the LES problems facing Eastern Europe today. Collectively, these Proceedings contain clear reports on: (a) methods for evaluating the cost effectiveness of alternative approaches to control pollution from small coal-fired boilers and furnaces; (b) cost-effective technologies for controlling pollution from coal-fired boilers and furnaces; (c) case studies ofmore » assessment of cost effective pollution control measures for selected cities in eastern Europe; and (d) approaches for actually implementing pollution control measures in cities in Eastern Europe. It is intended that the eastern/central European reader will find in these Proceedings useful measures that can be applied to control emissions and clean the air in his city or region. The conference was sponsored by the United States Agency for International Development (AID), the United States Department of Energy (DOE), and the Czech Ministry of Industry and Trade. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.« less

New alternatives for reference evapotranspiration estimation in West Africa using limited weather data and ancillary data supply strategies.

NASA Astrophysics Data System (ADS)

Landeras, Gorka; Bekoe, Emmanuel; Ampofo, Joseph; Logah, Frederick; Diop, Mbaye; Cisse, Madiama; Shiri, Jalal

2018-05-01

Accurate estimation of reference evapotranspiration ( ET 0 ) is essential for the computation of crop water requirements, irrigation scheduling, and water resources management. In this context, having a battery of alternative local calibrated ET 0 estimation methods is of great interest for any irrigation advisory service. The development of irrigation advisory services will be a major breakthrough for West African agriculture. In the case of many West African countries, the high number of meteorological inputs required by the Penman-Monteith equation has been indicated as constraining. The present paper investigates for the first time in Ghana, the estimation ability of artificial intelligence-based models (Artificial Neural Networks (ANNs) and Gene Expression Programing (GEPs)), and ancillary/external approaches for modeling reference evapotranspiration ( ET 0 ) using limited weather data. According to the results of this study, GEPs have emerged as a very interesting alternative for ET 0 estimation at all the locations of Ghana which have been evaluated in this study under different scenarios of meteorological data availability. The adoption of ancillary/external approaches has been also successful, moreover in the southern locations. The interesting results obtained in this study using GEPs and some ancillary approaches could be a reference for future studies about ET 0 estimation in West Africa.

Scenario and multiple criteria decision analysis for energy and environmental security of military and industrial installations.

PubMed

Karvetski, Christopher W; Lambert, James H; Linkov, Igor

2011-04-01

Military and industrial facilities need secure and reliable power generation. Grid outages can result in cascading infrastructure failures as well as security breaches and should be avoided. Adding redundancy and increasing reliability can require additional environmental, financial, logistical, and other considerations and resources. Uncertain scenarios consisting of emergent environmental conditions, regulatory changes, growth of regional energy demands, and other concerns result in further complications. Decisions on selecting energy alternatives are made on an ad hoc basis. The present work integrates scenario analysis and multiple criteria decision analysis (MCDA) to identify combinations of impactful emergent conditions and to perform a preliminary benefits analysis of energy and environmental security investments for industrial and military installations. Application of a traditional MCDA approach would require significant stakeholder elicitations under multiple uncertain scenarios. The approach proposed in this study develops and iteratively adjusts a scoring function for investment alternatives to find the scenarios with the most significant impacts on installation security. A robust prioritization of investment alternatives can be achieved by integrating stakeholder preferences and focusing modeling and decision-analytical tools on a few key emergent conditions and scenarios. The approach is described and demonstrated for a campus of several dozen interconnected industrial buildings within a major installation. Copyright © 2010 SETAC.

Using the Small Ruminant Nutrition System to develop and evaluate an alternative approach to estimating the dry matter intake of goats when accounting for ruminal fiber stratification.

PubMed

Regadas Filho, J G L; Tedeschi, L O; Cannas, A; Vieira, R A M; Rodrigues, M T

2014-11-01

The first objective of this research was to assess the ability of the Small Ruminant Nutrition System (SRNS) mechanistic model to predict metabolizable energy intake (MEI) and milk yield (MY) when using a heterogeneous fiber pool scenario (GnG1), compared with a traditional, homogeneous scenario (G1). The second objective was to evaluate an alternative approach to estimating the dry matter intake (DMI) of goats to be used in the SRNS model. The GnG1 scenario considers an age-dependent fractional transference rate for fiber particles from the first ruminal fiber pool (raft) to an escapable pool (λr), and that this second ruminal fiber pool (i.e., escapable pool) follows an age-independent fractional escape rate for fiber particles (ke). Scenario G1 adopted only a single fractional passage rate (kp). All parameters were estimated individually by using equations published in the literature, except for 2 passage rate equations in the G1 scenario: 1 developed with sheep data (G1-S) and another developed with goat data (G1-G). The alternative approach to estimating DMI was based on an optimization process using a series of dietary constraints. The DMI, MEI, and MY estimated for the GnG1 and G1 scenarios were compared with the results of an independent dataset (n=327) that contained information regarding DMI, MEI, MY, and milk and dietary compositions. The evaluation of the scenarios was performed using the coefficient of determination (R(2)) between the observed and predicted values, mean bias (MB), bias correction factor (Cb), and concordance correlation coefficient. The MEI estimated by the GnG1 scenario yielded precise and accurate values (R(2) = 082; MB = 0.21 Mcal/d; Cb = 0.98) similar to those of the G1-S (R(2) = 0.85; MB = 0.10 Mcal/d; Cb=0.99) and G1-G (R(2) = 0.84; MB = 0.18 Mcal/d; Cb = 0.98) scenarios. The results were also similar for the MY, but a substantial MB was found as follows: GnG1 (R(2) = 0.74; MB = 0.70 kg/d; Cb = 0.79), G1-S (R(2) = 0.71; MB = 0.58 kg/d(1); Cb = 0.85) and G1-G (R(2) = 0.71; MB = 0.65 kg/d; Cb = 0.82). The alternative approach for DMI prediction provided better results with the G1-G scenario (R(2)=0.88; MB = -71.67 g/d; Cb = 0.98). We concluded that the GnG1 scenario is valid within mechanistic models such as the SRNS and that the alternative approach for estimating DMI is reasonable and can be used in diet formulations for goats. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Status of NO sub x control for coal-fired power plants

NASA Technical Reports Server (NTRS)

Teixeira, D. P.

1978-01-01

The status of technologies for controlling emissions of oxides of nitrogen (NOx) from coal-fired power plants is reviewed. A discussion of current technology as well as future NOx control approaches is presented. Advanced combustion approaches are included as well as post-combustion alternatives such as catalytic and noncatalytic ammonia-bases systems and wet scrubbing. Special emphasis is given to unresolved development issues as they relate to practical applications on coal-fired power plants.

Engineering design, stress and thermal analysis, and documentation for SATS program

NASA Technical Reports Server (NTRS)

1973-01-01

An in-depth analysis and mechanical design of the solar array stowage and deployment arrangements for use in Small Applications Technology Satellite spacecraft is presented. Alternate approaches for the major elements of work are developed and evaluated. Elements include array stowage and deployment arrangements, the spacecraft and array behavior in the spacecraft despin mode, and the design of the main hinge and segment hinge assemblies. Feasibility calculations are performed and the preferred approach is identified.

PTC and Partner Products in the Creation of a Hurricane Wind Sensor

NASA Technical Reports Server (NTRS)

Randazzo, John; Voska, N. (Technical Monitor)

2002-01-01

This viewgraph presentation provides information on the development of a wind sensor for use during hurricanes. The objectives of this presentation are: (1) Educate the user unfamiliar with the modules as to what is available/lacking; (2) Share where some changes could be made; (3) Look at alternative approaches made possible by new releases/modules; (4) Use feedback to improve processes/approaches. The current pad wind sensors are cup-and-vane type anemometers.

From monocausality to systems thinking: a complementary and alternative conceptual approach for better understanding the development and prevention of sports injury.

PubMed

Hulme, Adam; Finch, Caroline F

The science of sports injury control, including both its cause and prevention, has largely been informed by a biomedical and mechanistic model of health. Traditional scientific practice in sports injury research has routinely involved collapsing the broader socioecological landscape down in order to analyse individual-level determinants of injury - whether biomechanical and/or behavioural. This approach has made key gains for sports injury prevention research and should be further encouraged and allowed to evolve naturally. However, the public health, Applied Human Factors and Ergonomics, and injury epidemiological literature more broadly, has accepted the value of a socioecological paradigm for better understanding disease and injury processes, and sports injury research will fall further behind unless it does the same. A complementary and alternative conceptual approach towards injury control known as systems thinking that builds on socioecological science, both methodologically and analytically, is readily available and fast developing in other research areas. This review outlines the historical progression of causal concepts in the field of epidemiology over the course of the modern scientific era. From here, causal concepts in injury epidemiology, and models of aetiology as found in the context of sports injury research are presented. The paper finishes by proposing a new research agenda that considers the potential for a systems thinking approach to further enhance sports injury aetiological understanding. A complementary systems paradigm, however, will require that sports injury epidemiologists bring their knowledge and skillsets forwards in an attempt to use, adapt, and even refine existing systems-based approaches. Alongside the natural development of conventional scientific methodologies and analyses in sports injury research, progressing forwards to a systems paradigm is now required.

Feasibility Study: New Knowledge Demands in Turbulent Business World

NASA Astrophysics Data System (ADS)

Sprice, Renate; Kirikova, Marite

Feasibility study is one of the early activities in information systems (IS) development when important decisions regarding choice among several possible systems development alternatives are to be made. In times of relatively stable business environment and waterfall model as a systems development approach, the role and methods of feasibility study where quite clear (Kendall and Kendall 1995). However, new software development methods and the necessity to develop more rapidly new IS or their parts may. challenge the possibility to evaluate project feasibility in the early stages of IS development.

Comparing Laser Interferometry and Atom Interferometry Approaches to Space-Based Gravitational-Wave Measurement

NASA Technical Reports Server (NTRS)

Baker, John; Thorpe, Ira

2012-01-01

Thoroughly studied classic space-based gravitational-wave missions concepts such as the Laser Interferometer Space Antenna (LISA) are based on laser-interferometry techniques. Ongoing developments in atom-interferometry techniques have spurred recently proposed alternative mission concepts. These different approaches can be understood on a common footing. We present an comparative analysis of how each type of instrument responds to some of the noise sources which may limiting gravitational-wave mission concepts. Sensitivity to laser frequency instability is essentially the same for either approach. Spacecraft acceleration reference stability sensitivities are different, allowing smaller spacecraft separations in the atom interferometry approach, but acceleration noise requirements are nonetheless similar. Each approach has distinct additional measurement noise issues.

Technical Review of the CENWP Computational Fluid Dynamics Model of the John Day Dam Forebay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rakowski, Cynthia L.; Serkowski, John A.; Richmond, Marshall C.

The US Army Corps of Engineers Portland District (CENWP) has developed a computational fluid dynamics (CFD) model of the John Day forebay on the Columbia River to aid in the development and design of alternatives to improve juvenile salmon passage at the John Day Project. At the request of CENWP, Pacific Northwest National Laboratory (PNNL) Hydrology Group has conducted a technical review of CENWP's CFD model run in CFD solver software, STAR-CD. PNNL has extensive experience developing and applying 3D CFD models run in STAR-CD for Columbia River hydroelectric projects. The John Day forebay model developed by CENWP is adequatelymore » configured and validated. The model is ready for use simulating forebay hydraulics for structural and operational alternatives. The approach and method are sound, however CENWP has identified some improvements that need to be made for future models and for modifications to this existing model.« less

An integrated modeling approach to support management decisions of coupled groundwater-agricultural systems under multiple uncertainties

NASA Astrophysics Data System (ADS)

Hagos Subagadis, Yohannes; Schütze, Niels; Grundmann, Jens

2015-04-01

The planning and implementation of effective water resources management strategies need an assessment of multiple (physical, environmental, and socio-economic) issues, and often requires new research in which knowledge of diverse disciplines are combined in a unified methodological and operational frameworks. Such integrative research to link different knowledge domains faces several practical challenges. Such complexities are further compounded by multiple actors frequently with conflicting interests and multiple uncertainties about the consequences of potential management decisions. A fuzzy-stochastic multiple criteria decision analysis tool was developed in this study to systematically quantify both probabilistic and fuzzy uncertainties associated with complex hydrosystems management. It integrated physical process-based models, fuzzy logic, expert involvement and stochastic simulation within a general framework. Subsequently, the proposed new approach is applied to a water-scarce coastal arid region water management problem in northern Oman, where saltwater intrusion into a coastal aquifer due to excessive groundwater extraction for irrigated agriculture has affected the aquifer sustainability, endangering associated socio-economic conditions as well as traditional social structure. Results from the developed method have provided key decision alternatives which can serve as a platform for negotiation and further exploration. In addition, this approach has enabled to systematically quantify both probabilistic and fuzzy uncertainties associated with the decision problem. Sensitivity analysis applied within the developed tool has shown that the decision makers' risk aversion and risk taking attitude may yield in different ranking of decision alternatives. The developed approach can be applied to address the complexities and uncertainties inherent in water resources systems to support management decisions, while serving as a platform for stakeholder participation.

Computational approaches to metabolic engineering utilizing systems biology and synthetic biology.

PubMed

Fong, Stephen S

2014-08-01

Metabolic engineering modifies cellular function to address various biochemical applications. Underlying metabolic engineering efforts are a host of tools and knowledge that are integrated to enable successful outcomes. Concurrent development of computational and experimental tools has enabled different approaches to metabolic engineering. One approach is to leverage knowledge and computational tools to prospectively predict designs to achieve the desired outcome. An alternative approach is to utilize combinatorial experimental tools to empirically explore the range of cellular function and to screen for desired traits. This mini-review focuses on computational systems biology and synthetic biology tools that can be used in combination for prospective in silico strain design.

Shuttle user analysis (study 2.2). Volume 2: User charge analysis. Part 1: Summary

NASA Technical Reports Server (NTRS)

1974-01-01

Alternative candidate STS flight charge approaches which will provide a basis for NASA's determination of an STS flight charge policy were analyzed. The analysis used STS transportation costs furnished by NASA. The STS User Charge Analysis was accomplished by (1) generating criteria for evaluation of alternative flight charge approaches, (2) defining alternative flight charge approaches, (3) computing flight charges for selected missions, (4) evaluating results using the criteria generated under (1), and (5) recommending flight charge approaches to be used as a basis for the formulation of a STS user flight charge policy.

Alternative Medications for Medications Included in the Use of High-Risk Medications in the Elderly and Potentially Harmful Drug–Disease Interactions in the Elderly Quality Measures

PubMed Central

Hanlon, Joseph T.; Semla, Todd P.; Schmader, Kenneth E.

2016-01-01

The National Committee for Quality Assurance (NCQA) and the Pharmacy Quality Alliance (PQA) use the American Geriatrics Society (AGS) Beers Criteria to designate the quality measure Use of High-Risk Medications in the Elderly (HRM). The Centers for Medicare and Medicaid Services (CMS) use the HRM measure to monitor and evaluate the quality of care provided to Medicare beneficiaries. NCQA additionally uses the AGS Beers Criteria to designate the quality measure Potentially Harmful Drug–Disease Interactions in the Elderly. Medications included in these measures may be harmful to elderly adults, negatively affect a health care plan’s quality ratings, and be denied as a health care plan drug benefit. Prescribers, pharmacists, patients, and health care plans may benefit from evidence-based alternative medication treatments to avoid these problems. Therefore the goal of this work was to develop a list of alternative medications to those included in the two measures. The authors conducted a comprehensive literature review for 2000 to 2014 and a search of their personal files. From the evidence, they prepared a list of drug-therapy alternatives with supporting references. A reference list of non-pharmacological approaches was also provided when appropriate. NCQA, PQA, the 2015 AGS Beers Criteria panel, and the Executive Committee of the AGS reviewed the drug therapy alternatives and nonpharmacological approaches. Recommendations by these groups were incorporated into the final list of alternatives. The final product of drug-therapy alternatives to medications included in the two quality measures and some nonpharmacological resources will be useful to health professionals, consumers, payers, and health systems that care for older adults. PMID:26447889

Selection of reference standard during method development using the analytical hierarchy process.

PubMed

Sun, Wan-yang; Tong, Ling; Li, Dong-xiang; Huang, Jing-yi; Zhou, Shui-ping; Sun, Henry; Bi, Kai-shun

2015-03-25

Reference standard is critical for ensuring reliable and accurate method performance. One important issue is how to select the ideal one from the alternatives. Unlike the optimization of parameters, the criteria of the reference standard are always immeasurable. The aim of this paper is to recommend a quantitative approach for the selection of reference standard during method development based on the analytical hierarchy process (AHP) as a decision-making tool. Six alternative single reference standards were assessed in quantitative analysis of six phenolic acids from Salvia Miltiorrhiza and its preparations by using ultra-performance liquid chromatography. The AHP model simultaneously considered six criteria related to reference standard characteristics and method performance, containing feasibility to obtain, abundance in samples, chemical stability, accuracy, precision and robustness. The priority of each alternative was calculated using standard AHP analysis method. The results showed that protocatechuic aldehyde is the ideal reference standard, and rosmarinic acid is about 79.8% ability as the second choice. The determination results successfully verified the evaluation ability of this model. The AHP allowed us comprehensive considering the benefits and risks of the alternatives. It was an effective and practical tool for optimization of reference standards during method development. Copyright © 2015 Elsevier B.V. All rights reserved.

Moving further upstream: from toxics reduction to the precautionary principle.

PubMed

Mayer, Brian; Brown, Phil; Linder, Meadow

2002-01-01

Early policies to reduce the amount of toxic waste in the environment focused on cleaning up downstream sources of pollution, such as toxic disposal sites. Public attention in the 1980s encouraged both industry and government to develop an alternative to this command-and-control approach. This article describes the emergence of that alternative-pollution prevention-and its application in Massachusetts through the 1989 Toxics Use Reduction Act. Pollution prevention focuses on the sources of pollution, both metaphorically and physically, more upstream than its predecessors. The success of the Toxics Use Reduction Act in Massachusetts helped create an opportunity where an alternative pollution prevention paradigm could develop. That paradigm, the precautionary principle, is popular among environment activists because it focuses further upstream than pollution prevention by calling attention to the role the social construction of risk plays in decisions regarding the use of hazardous substances. The authors examine the evolution of the precautionary principle through an investigation of three major pathways in its development and expansion. The article concludes with a discussion of the increased potential for protecting public health and the environment afforded by this new perspective.

Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH.

PubMed

Wang, Jing; MacEwan, Sarah R; Chilkoti, Ashutosh

2017-02-08

Understanding the intracellular distribution and trafficking of nanoparticle drug carriers is necessary to elucidate their mechanisms of drug delivery and is helpful in the rational design of novel nanoparticle drug delivery systems. The traditional immunofluorescence method to study intracellular distribution of nanoparticles using organelle-specific antibodies is laborious and subject to artifacts. As an alternative, we developed a new method that exploits ratiometric fluorescence imaging of a pH-sensitive Lysosensor dye to visualize and quantify the spatial distribution of nanoparticles in the endosomes and lysosomes of live cells. Using this method, we compared the endolysosomal distribution of cell-penetrating peptide (CPP)-functionalized micelles to unfunctionalized micelles and found that CPP-functionalized micelles exhibited faster endosome-to-lysosome trafficking than unfunctionalized micelles. Ratiometric fluorescence imaging of pH-sensitive Lysosensor dye allows rapid quantitative mapping of nanoparticle distribution in endolysosomes in live cells while minimizing artifacts caused by extensive sample manipulation typical of alternative approaches. This new method can thus serve as an alternative to traditional immunofluorescence approaches to study the intracellular distribution and trafficking of nanoparticles within endosomes and lysosomes.

100-KE REACTOR CORE REMOVAL PROJECT ALTERNATIVE ANALYSIS WORKSHOP REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

HARRINGTON RA

2010-01-15

On December 15-16, 2009, a 100-KE Reactor Core Removal Project Alternative Analysis Workshop was conducted at the Washington State University Consolidated Information Center, Room 214. Colburn Kennedy, Project Director, CH2M HILL Plateau Remediation Company (CHPRC) requested the workshop and Richard Harrington provided facilitation. The purpose of the session was to select the preferred Bio Shield Alternative, for integration with the Thermal Shield and Core Removal and develop the path forward to proceed with project delivery. Prior to this workshop, the S.A. Robotics (SAR) Obstruction Removal Alternatives Analysis (565-DLV-062) report was issued, for use prior to and throughout the session, tomore » all the team members. The multidisciplinary team consisted ofrepresentatives from 100-KE Project Management, Engineering, Radcon, Nuclear Safety, Fire Protection, Crane/Rigging, SAR Project Engineering, the Department of Energy Richland Field Office, Environmental Protection Agency, Washington State Department of Ecology, Defense Nuclear Facility Safety Board, and Deactivation and Decommission subject matter experts from corporate CH2M HILL and Lucas. Appendix D contains the workshop agenda, guidelines and expectations, opening remarks, and attendance roster going into followed throughout the workshop. The team was successful in selecting the preferred alternative and developing an eight-point path forward action plan to proceed with conceptual design. Conventional Demolition was selected as the preferred alternative over two other alternatives: Diamond Wire with Options, and Harmonic Delamination with Conventional Demolition. The teams preferred alternative aligned with the SAR Obstruction Removal Alternative Analysis report conclusion. However, the team identified several Path Forward actions, in Appendix A, which upon completion will solidify and potentially enhance the Conventional Demolition alternative with multiple options and approaches to achieve project delivery. In brief, the Path Forward was developed to reconsider potential open air demolition areas; characterize to determine if any zircaloy exists, evaluate existing concrete data to determine additional characterization needs, size the new building to accommodate human machine interface and tooling, consider bucket thumb and use ofshape-charges in design, and finally to utilize complex-wide and industry explosive demolition lessons learned in the design approach. Appendix B documents these results from the team's use ofValue Engineering process tools entitled Weighted Analysis Alternative Matrix, Matrix Conclusions, Evaluation Criteria, and Alternative Advantages and Disadvantages. These results were further supported with the team's validation of parking-lot information sheets: memories (potential ideas to consider), issues/concerns, and assumptions, contained in Appendix C. Appendix C also includes the recorded workshop flipchart notes taken from the SAR Alternatives and Project Overview presentations. The SAR workshop presentations, including a 3-D graphic illustration demonstration video have been retained in the CHPRC project file, and were not included in this report due to size limitations. The workshop concluded with a round robin close-out where each member was engaged for any last minute items and meeting utility. In summary, the team felt the session was value added and looked forward to proceeding with the recommended actions and conceptual design.« less

Optimisation of Critical Infrastructure Protection: The SiVe Project on Airport Security

NASA Astrophysics Data System (ADS)

Breiing, Marcus; Cole, Mara; D'Avanzo, John; Geiger, Gebhard; Goldner, Sascha; Kuhlmann, Andreas; Lorenz, Claudia; Papproth, Alf; Petzel, Erhard; Schwetje, Oliver

This paper outlines the scientific goals, ongoing work and first results of the SiVe research project on critical infrastructure security. The methodology is generic while pilot studies are chosen from airport security. The outline proceeds in three major steps, (1) building a threat scenario, (2) development of simulation models as scenario refinements, and (3) assessment of alternatives. Advanced techniques of systems analysis and simulation are employed to model relevant airport structures and processes as well as offences. Computer experiments are carried out to compare and optimise alternative solutions. The optimality analyses draw on approaches to quantitative risk assessment recently developed in the operational sciences. To exploit the advantages of the various techniques, an integrated simulation workbench is build up in the project.

Setting conservation management thresholds using a novel participatory modeling approach.

PubMed

Addison, P F E; de Bie, K; Rumpff, L

2015-10-01

We devised a participatory modeling approach for setting management thresholds that show when management intervention is required to address undesirable ecosystem changes. This approach was designed to be used when management thresholds: must be set for environmental indicators in the face of multiple competing objectives; need to incorporate scientific understanding and value judgments; and will be set by participants with limited modeling experience. We applied our approach to a case study where management thresholds were set for a mat-forming brown alga, Hormosira banksii, in a protected area management context. Participants, including management staff and scientists, were involved in a workshop to test the approach, and set management thresholds to address the threat of trampling by visitors to an intertidal rocky reef. The approach involved trading off the environmental objective, to maintain the condition of intertidal reef communities, with social and economic objectives to ensure management intervention was cost-effective. Ecological scenarios, developed using scenario planning, were a key feature that provided the foundation for where to set management thresholds. The scenarios developed represented declines in percent cover of H. banksii that may occur under increased threatening processes. Participants defined 4 discrete management alternatives to address the threat of trampling and estimated the effect of these alternatives on the objectives under each ecological scenario. A weighted additive model was used to aggregate participants' consequence estimates. Model outputs (decision scores) clearly expressed uncertainty, which can be considered by decision makers and used to inform where to set management thresholds. This approach encourages a proactive form of conservation, where management thresholds and associated actions are defined a priori for ecological indicators, rather than reacting to unexpected ecosystem changes in the future. © 2015 The Authors Conservation Biology published by Wiley Periodicals, Inc. on behalf of Society for Conservation Biology.

An environmental decision framework applied to marine engine control technologies.

PubMed

Corbett, James J; Chapman, David

2006-06-01

This paper develops a decision framework for considering emission control technologies on marine engines, informed by standard decision theory, with an open structure that may be adapted by operators with specific vessel and technology attributes different from those provided here. Attributes relate objectives important to choosing control technologies with specific alternatives that may meet several of the objectives differently. The transparent framework enables multiple stakeholders to understand how different subjective judgments and varying attribute properties may result in different technology choices. Standard scoring techniques ensure that attributes are not biased by subjective scoring and that weights are the primary quantitative input where subjective preferences are exercised. An expected value decision structure is adopted that considers probabilities (likelihood) that a given alternative can meet its claims; alternative decision criteria are discussed. Capital and annual costs are combined using a net present value approach. An iterative approach is advocated that allows for screening and disqualifying alternatives that do not meet minimum conditions for acceptance, such as engine warranty or U.S. Coast Guard requirements. This decision framework assists vessel operators in considering explicitly important attributes and in representing choices clearly to other stakeholders concerned about reducing air pollution from vessels. This general decision structure may also be applied similarly to other environmental controls in marine applications.

Measuring decision weights in recognition experiments with multiple response alternatives: comparing the correlation and multinomial-logistic-regression methods.

PubMed

Dai, Huanping; Micheyl, Christophe

2012-11-01

Psychophysical "reverse-correlation" methods allow researchers to gain insight into the perceptual representations and decision weighting strategies of individual subjects in perceptual tasks. Although these methods have gained momentum, until recently their development was limited to experiments involving only two response categories. Recently, two approaches for estimating decision weights in m-alternative experiments have been put forward. One approach extends the two-category correlation method to m > 2 alternatives; the second uses multinomial logistic regression (MLR). In this article, the relative merits of the two methods are discussed, and the issues of convergence and statistical efficiency of the methods are evaluated quantitatively using Monte Carlo simulations. The results indicate that, for a range of values of the number of trials, the estimated weighting patterns are closer to their asymptotic values for the correlation method than for the MLR method. Moreover, for the MLR method, weight estimates for different stimulus components can exhibit strong correlations, making the analysis and interpretation of measured weighting patterns less straightforward than for the correlation method. These and other advantages of the correlation method, which include computational simplicity and a close relationship to other well-established psychophysical reverse-correlation methods, make it an attractive tool to uncover decision strategies in m-alternative experiments.

Alternatives to antibiotics: a symposium on the challenges and solutions for animal production.

PubMed

Seal, Bruce S; Lillehoj, Hyun S; Donovan, David M; Gay, Cyril G

2013-06-01

Antibiotics are one of the most important medical discoveries of the 20th century and will remain an essential tool for treating animal and human diseases in the 21st century. However, antibiotic resistance among bacterial pathogens and concerns over their extensive use in food animals has garnered global interest in limiting antibiotic use in animal agriculture. Yet, limiting the availability of medical interventions to prevent and control animal diseases on the farm will directly impact global food security and safety as well as animal and human health. Insufficient attention has been given to the scientific breakthroughs and novel technologies that provide alternatives to antibiotics. The objectives of the symposium 'Alternatives to Antibiotics' were to highlight promising research results and novel technologies that could potentially lead to alternatives to conventional antibiotics, and assess challenges associated with their commercialization, and provide actionable strategies to support development of alternative antimicrobials. The symposium focused on the latest scientific breakthroughs and technologies that could provide new options and alternative strategies for preventing and treating diseases of animals. Some of these new technologies have direct applications as medical interventions for human health, but the focus of the symposium was animal production, animal health and food safety during food-animal production. Five subject areas were explored in detail through scientific presentations and expert panel discussions, including: (1) alternatives to antibiotics, lessons from nature; (2) immune modulation approaches to enhance disease resistance and to treat animal diseases; (3) gut microbiome and immune development, health and diseases; (4) alternatives to antibiotics for animal production; and (5) regulatory pathways to enable the licensure of alternatives to antibiotics.

Reaching Mars: multi-criteria R&D portfolio selection for Mars exploration technology planning

NASA Technical Reports Server (NTRS)

Smith, J. H.; Dolgin, B. P.; Weisbin, C. R.

2003-01-01

The exploration of Mars has been the focus of increasing scientific interest about the planet and its relationship to Earth. A multi-criteria decision-making approach was developed to address the question, Given a Mars program composed of mission concepts dependent on a variety of alternative technology development programs, which combination of technologies would enable missions to maximize science return under a constrained budget?.

Stakeholder engagement in scenario development process - bioenergy production and biodiversity conservation in eastern Finland.

PubMed

Haatanen, Anniina; den Herder, Michael; Leskinen, Pekka; Lindner, Marcus; Kurttila, Mikko; Salminen, Olli

2014-03-15

In this study participatory approaches were used to develop alternative forest resource management scenarios with particular respect to the effects on increased use of forest bioenergy and its effect on biodiversity in Eastern Finland. As technical planning tools, we utilized a forest management planning system (MELA) and the Tool for Sustainability Impact Assessment (ToSIA) to visualize the impacts of the scenarios. We organized a stakeholder workshop where group discussions were used as a participatory method to get the stakeholder preferences and insights concerning forest resource use in the year 2030. Feedback from the workshop was then complemented with a questionnaire. Based on the results of the workshop and a questionnaire we developed three alternative forest resource scenarios: (1) bioenergy 2030 - in which energy production is more centralized and efficient; (2) biodiversity 2030 - in which harvesting methods are more nature friendly and protected forests make up 10% of the total forest area; and (3) mixed bioenergy + biodiversity 2030 scenario - in which wood production, recreation and nature protection are assigned to the most suitable areas. The study showed that stakeholder engagement combined with the MELA and ToSIA tools can be a useful approach in scenario development. Copyright © 2014 Elsevier Ltd. All rights reserved.

Pros, Cons, and Alternatives to Weight Based Cost Estimating

NASA Technical Reports Server (NTRS)

Joyner, Claude R.; Lauriem, Jonathan R.; Levack, Daniel H.; Zapata, Edgar

2011-01-01

Many cost estimating tools use weight as a major parameter in projecting the cost. This is often combined with modifying factors such as complexity, technical maturity of design, environment of operation, etc. to increase the fidelity of the estimate. For a set of conceptual designs, all meeting the same requirements, increased weight can be a major driver in increased cost. However, once a design is fixed, increased weight generally decreases cost, while decreased weight generally increases cost - and the relationship is not linear. Alternative approaches to estimating cost without using weight (except perhaps for materials costs) have been attempted to try to produce a tool usable throughout the design process - from concept studies through development. This paper will address the pros and cons of using weight based models for cost estimating, using liquid rocket engines as the example. It will then examine approaches that minimize the impct of weight based cost estimating. The Rocket Engine- Cost Model (RECM) is an attribute based model developed internally by Pratt & Whitney Rocketdyne for NASA. RECM will be presented primarily to show a successful method to use design and programmatic parameters instead of weight to estimate both design and development costs and production costs. An operations model developed by KSC, the Launch and Landing Effects Ground Operations model (LLEGO), will also be discussed.

An integrated approach for facilities planning by ELECTRE method

NASA Astrophysics Data System (ADS)

Elbishari, E. M. Y.; Hazza, M. H. F. Al; Adesta, E. Y. T.; Rahman, Nur Salihah Binti Abdul

2018-01-01

Facility planning is concerned with the design, layout, and accommodation of people, machines and activities of a system. Most of the researchers try to investigate the production area layout and the related facilities. However, few of them try to investigate the relationship between the production space and its relationship with service departments. The aim of this research to is to integrate different approaches in order to evaluate, analyse and select the best facilities planning method that able to explain the relationship between the production area and other supporting departments and its effect on human efforts. To achieve the objective of this research two different approaches have been integrated: Apple’s layout procedure as one of the effective tools in planning factories, ELECTRE method as one of the Multi Criteria Decision Making methods (MCDM) to minimize the risk of getting poor facilities planning. Dalia industries have been selected as a case study to implement our integration the factory have been divided two main different area: the whole facility (layout A), and the manufacturing area (layout B). This article will be concerned with the manufacturing area layout (Layout B). After analysing the data gathered, the manufacturing area was divided into 10 activities. There are five factors that the alternative were compared upon which are: Inter department satisfactory level, total distance travelled for workers, total distance travelled for the product, total time travelled for the workers, and total time travelled for the product. Three different layout alternatives have been developed in addition to the original layouts. Apple’s layout procedure was used to study and evaluate the different alternatives layouts, the study and evaluation of the layouts was done by calculating scores for each of the factors. After obtaining the scores from evaluating the layouts, ELECTRE method was used to compare the proposed alternatives with each other and with the existing layout; ELECTRE compares the alternatives based on their concordance and discordance indices. The alternatives were ranked from best to worst where regarding to the layouts concerned with the manufacturing area B.4 is the best alternative.

New psychological therapies for irritable bowel syndrome: mindfulness, acceptance and commitment therapy (ACT).

PubMed

Sebastián Sánchez, Beatriz; Gil Roales-Nieto, Jesús; Ferreira, Nuno Bravo; Gil Luciano, Bárbara; Sebastián Domingo, Juan José

2017-09-01

The current goal of treatment in irritable bowel syndrome (IBS) focuses primarily on symptom management and attempts to improve quality of life. Several treatments are at the disposal of physicians; lifestyle and dietary management, pharmacological treatments and psychological interventions are the most used and recommended. Psychological treatments have been proposed as viable alternatives or compliments to existing care models. Most forms of psychological therapies studied have been shown to be helpful in reducing symptoms and in improving the psychological component of anxiety/depression and health-related quality of life. According to current NICE/NHS guidelines, physicians should consider referral for psychological treatment in patients who do not respond to pharmacotherapy for a period of 12 months and develop a continuing symptom profile (described as refractory irritable bowel syndrome). Cognitive behavioral therapy (CBT) is the best studied treatment and seems to be the most promising therapeutic approach. However, some studies have challenged the effectiveness of this therapy for irritable bowel syndrome. One study concluded that cognitive behavioral therapy is no more effective than placebo attention control condition and another study showed that the beneficial effects wane after six months of follow-up. A review of mind/body approaches to irritable bowel syndrome has therefore suggested that alternate strategies targeting mechanisms other than thought content change might be helpful, specifically mindfulness and acceptance-based approaches. In this article we review these new psychological treatment approaches in an attempt to raise awareness of alternative treatments to gastroenterologists that treat this clinical syndrome.

Bridge approach slabs for Missouri DOT field evaluation of alternative and cost efficient bridge approach slabs.

DOT National Transportation Integrated Search

2013-05-01

Based on a recent study on cost efficient alternative bridge approach slab (BAS) designs (Thiagarajan et : al. 2010) has recommended three new BAS designs for possible implementation by MoDOT namely a) 20 feet cast-inplace : slab with sleeper slab (C...

Propensity Score Analysis: An Alternative Statistical Approach for HRD Researchers

ERIC Educational Resources Information Center

Keiffer, Greggory L.; Lane, Forrest C.

2016-01-01

Purpose: This paper aims to introduce matching in propensity score analysis (PSA) as an alternative statistical approach for researchers looking to make causal inferences using intact groups. Design/methodology/approach: An illustrative example demonstrated the varying results of analysis of variance, analysis of covariance and PSA on a heuristic…

Bringing political ecology into critical medical anthropology: a challenge to biocultural approaches.

PubMed

Baer, H A

1996-12-01

This essay presents an effort to incorporate the "environment" into critical medical anthropology. Rather than relying upon the multifactorial approach characteristic of medical ecology or biocultural approaches in medical anthropology, it urges critical medical anthropologists to turn to the burgeoning literature on eco-Marxism, eco-socialism, or political ecology in their efforts to develop a political ecology of health. Given that political ecologists generally advocate democratic eco-socialism as a meaningful alternative to the capitalist world system, this essay also presents a critical examination of the environmental record of post-revolutionary societies.

Life extending control for rocket engines

NASA Technical Reports Server (NTRS)

Lorenzo, C. F.; Saus, J. R.; Ray, A.; Carpino, M.; Wu, M.-K.

1992-01-01

The concept of life extending control is defined. A brief discussion of current fatigue life prediction methods is given and the need for an alternative life prediction model based on a continuous functional relationship is established. Two approaches to life extending control are considered: (1) the implicit approach which uses cyclic fatigue life prediction as a basis for control design; and (2) the continuous life prediction approach which requires a continuous damage law. Progress on an initial formulation of a continuous (in time) fatigue model is presented. Finally, nonlinear programming is used to develop initial results for life extension for a simplified rocket engine (model).

Modular reservoir concept for MEMS-based transdermal drug delivery systems

NASA Astrophysics Data System (ADS)

Cantwell, Cara T.; Wei, Pinghung; Ziaie, Babak; Rao, Masaru P.

2014-11-01

While MEMS-based transdermal drug delivery device development efforts have typically focused on tightly-integrated solutions, we propose an alternate conception based upon a novel, modular drug reservoir approach. By decoupling the drug storage functionality from the rest of the delivery system, this approach seeks to minimize cold chain storage volume, enhance compatibility with conventional pharmaceutical practices, and allow independent optimization of reservoir device design, materials, and fabrication. Herein, we report the design, fabrication, and preliminary characterization of modular reservoirs that demonstrate the virtue of this approach within the application context of transdermal insulin administration for diabetes management.

Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs.

PubMed

Karagianni, Anna; Malamatari, Maria; Kachrimanis, Kyriakos

2018-01-25

Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmaceutical interest, along with their in vitro properties and available in vivo data and characterization techniques are discussed, highlighting the potential of cocrystals as an attractive route for drug development.

Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud

PubMed Central

Arora, Rajesh; Chawla, R.; Marwah, Rohit; Arora, P.; Sharma, R. K.; Kaushik, Vinod; Goel, R.; Kaur, A.; Silambarasan, M.; Tripathi, R. P.; Bhardwaj, J. R.

2011-01-01

The emergence of novel H1N1 has posed a situation that warrants urgent global attention. Though antiviral drugs are available in mainstream medicine for treating symptoms of swine flu, currently there is no preventive medicine available. Even when available, they would be in short supply and ineffective in a pandemic situation, for treating the masses worldwide. Besides the development of drug resistance, emergence of mutant strains of the virus, emergence of a more virulent strain, prohibitive costs of available drugs, time lag between vaccine developments, and mass casualties would pose difficult problems. In view of this, complementary and alternative medicine (CAM) offers a plethora of interesting preventive possibilities in patients. Herbs exhibit a diverse array of biological activities and can be effectively harnessed for managing pandemic flu. Potentially active herbs can serve as effective anti influenza agents. The role of CAM for managing novel H1N1 flu and the mode of action of these botanicals is presented here in an evidence-based approach that can be followed to establish their potential use in the management of influenza pandemics. The complementary and alternative medicine approach deliberated in the paper should also be useful in treating the patients with serious influenza in non pandemic situations. PMID:20976081

HSI top-down requirements analysis for ship manpower reduction

NASA Astrophysics Data System (ADS)

Malone, Thomas B.; Bost, J. R.

2000-11-01

U.S. Navy ship acquisition programs such as DD 21 and CVNX are increasingly relying on top down requirements analysis (TDRA) to define and assess design approaches for workload and manpower reduction, and for ensuring required levels of human performance, reliability, safety, and quality of life at sea. The human systems integration (HSI) approach to TDRA begins with a function analysis which identifies the functions derived from the requirements in the Operational Requirements Document (ORD). The function analysis serves as the function baseline for the ship, and also supports the definition of RDT&E and Total Ownership Cost requirements. A mission analysis is then conducted to identify mission scenarios, again based on requirements in the ORD, and the Design Reference Mission (DRM). This is followed by a mission/function analysis which establishes the function requirements to successfully perform the ship's missions. Function requirements of major importance for HSI are information, performance, decision, and support requirements associated with each function. An allocation of functions defines the roles of humans and automation in performing the functions associated with a mission. Alternate design concepts, based on function allocation strategies, are then described, and task networks associated with the concepts are developed. Task network simulations are conducted to assess workloads and human performance capabilities associated with alternate concepts. An assessment of the affordability and risk associated with alternate concepts is performed, and manning estimates are developed for feasible design concepts.

Alternative technological development for RF hybridization

NASA Astrophysics Data System (ADS)

Antônio Finardi, Célio; da Fontoura Ponchet, André; Battesini Adamo, Cristina; Flacker, Alexander; Cotrin Teixeira, Ricardo; Panepucci, Roberto Ricardo

2017-03-01

The paper presents a technological solution for high frequency packaging platform evaluated up to 40 GHz. The main purpose of this development was to define an alternative hybrid technology that is more flexible and faster to prototype compared with thin film or multi chip module (MCM-D). The alternative technology also shows adequate performance for high bit rate solutions integrating optical and electronics blocks. This approach consists of a soft substrate (laminate material), plating processes (electroless Ni-P/Au, electrolytic Au) and lithography patterning. Ground coplanar waveguide was used for microwave structures with excellent ground planes connections due to easy via holes implementation. We present results of high frequency packaging of important RF blocks, such as integrated broadband bias-T, transimpedance amplifier ICs and silicon photonics optical modulators. The paper demonstrates a solution for high frequency hybridization that can be implemented with standard substrates, designed with any shape and with large numbers of metalized via holes and compatible with usual assembling techniques.

The Development of Solar Sail Propulsion for NASA Science Missions to the Inner Solar System

NASA Technical Reports Server (NTRS)

Montgomery, Edward E, IV; Johnson, Charles Les

2004-01-01

This paper examines recent assessments of the technology challenges facing solar sails, identifies the systems and technologies needing development, and the approach employed by NASA's In-space Propulsion Program in NASA to achieve near term products that move this important technology from low technology readiness level (TRL) toward the goal of application to science missions in near earth space and beyond. The status of on-going efforts to design, build, and test ground demonstrators of alternate approaches to structures (inflatable versus rigid), membrane materials, optical shape sensing, and attitude control will be presented along with planned future investments.

Integrated hydrogen/oxygen technology applied to auxiliary propulsion systems

NASA Technical Reports Server (NTRS)

Gerhardt, David L.

1990-01-01

The purpose of the Integrated Hydrogen/Oxygen Technology (IHOT) study was to determine if the vehicle/mission needs and technology of the 1990's support development of an all cryogenic H2/O2 system. In order to accomplish this, IHOT adopted the approach of designing Integrated Auxiliary Propulsion Systems (IAPS) for a representative manned vehicle; the advanced manned launch system. The primary objectives were to develop IAPS concepts which appeared to offer viable alternatives to state-of-the-art (i.e., hypergolic, or earth-storable) APS approaches. The IHOT study resulted in the definition of three APS concepts; two cryogenic IAPS, and a third concept utilizing hypergolic propellants.

Evaluation of small area crop estimation techniques using LANDSAT- and ground-derived data. [South Dakota

NASA Technical Reports Server (NTRS)

Amis, M. L.; Martin, M. V.; Mcguire, W. G.; Shen, S. S. (Principal Investigator)

1982-01-01

Studies completed in fiscal year 1981 in support of the clustering/classification and preprocessing activities of the Domestic Crops and Land Cover project. The theme throughout the study was the improvement of subanalysis district (usually county level) crop hectarage estimates, as reflected in the following three objectives: (1) to evaluate the current U.S. Department of Agriculture Statistical Reporting Service regression approach to crop area estimation as applied to the problem of obtaining subanalysis district estimates; (2) to develop and test alternative approaches to subanalysis district estimation; and (3) to develop and test preprocessing techniques for use in improving subanalysis district estimates.

Avoiding your greatest fear--malpractice.

PubMed

Coy, Kenneth; Stratton, Russell

2002-01-01

This article discusses ten clinically based behavioral approaches to minimizing the risk of a malpractice claim. Suggestions are stated in both a positive and negative way and ranked from least significant to most significant. Recommendations include the need to develop effective listening skills; learning to communicate with patients verbally and in writing; keeping patient expectations realistic; being thorough when examining and diagnosing; and knowing one's limitations. Also included is the need to inform patients concerning adverse events; keeping written records of what was said and done; discussing alternatives, risks, complications, and fees in advance; and developing a relationship with patients based on mutual respect and trust. Case examples are presented for each approach.

Determination of glucose concentrations using photonic crystal LEDs

NASA Astrophysics Data System (ADS)

Liao, Yu-Yang; Chen, Yung-Tsan; Chang, Cheng-Yu; Lan, Wen-Yi; Huang, Jian-Jang

2016-09-01

As internet of things (IOT) has become a popular topic in current consumer electronics, there is a demand for cost-effective sensors to monitor bio-signals. Traditional optical sensors employ low-dimensional gratings and high-resolution spectrometers to detect the refractive index changes of the solutions. In this work, we develop an alternative approach to correlate the concentration of molecules to the band diagrams of the photonic crystals. A relatively low-resolution spectrum analyzer can be employed, yet achieves higher sensitivity than traditional approaches.

High Energy 2-Micron Solid-State Laser Transmitter for NASA's Airborne CO2 Measurements

NASA Technical Reports Server (NTRS)

Singh, Upendra N.; Yu, Jirong; Petros, Mulugeta; Bai, Yingxin

2012-01-01

A 2-micron pulsed, Integrated Path Differential Absorption (IPDA) lidar instrument for ground and airborne atmospheric CO2 concentration measurements via direct detection method is being developed at NASA Langley Research Center. This instrument will provide an alternate approach to measure atmospheric CO2 concentrations with significant advantages. A high energy pulsed approach provides high-precision measurement capability by having high signal-to-noise level and unambiguously eliminates the contamination from aerosols and clouds that can bias the IPDA measurement.

Noninvasive Prenatal Detection of Trisomy 21 by Targeted Semiconductor Sequencing: A Technical Feasibility Study.

PubMed

Xi, Yanwei; Arbabi, Aryan; McNaughton, Amy J M; Hamilton, Alison; Hull, Danna; Perras, Helene; Chiu, Tillie; Morrison, Shawna; Goldsmith, Claire; Creede, Emilie; Anger, Gregory J; Honeywell, Christina; Cloutier, Mireille; Macchio, Natasha; Kiss, Courtney; Liu, Xudong; Crocker, Susan; Davies, Gregory A; Brudno, Michael; Armour, Christine M

2017-01-01

To develop an alternate noninvasive prenatal testing method for the assessment of trisomy 21 (T21) using a targeted semiconductor sequencing approach. A customized AmpliSeq panel was designed with 1,067 primer pairs targeting specific regions on chromosomes 21, 18, 13, and others. A total of 235 samples, including 30 affected with T21, were sequenced with an Ion Torrent Proton sequencer, and a method was developed for assessing the probability of fetal aneuploidy via derivation of a risk score. Application of the derived risk score yields a bimodal distribution, with the affected samples clustering near 1.0 and the unaffected near 0. For a risk score cutoff of 0.345, above which all would be considered at "high risk," all 30 T21-positive pregnancies were correctly predicted to be affected, and 199 of the 205 non-T21 samples were correctly predicted. The average hands-on time spent on library preparation and sequencing was 19 h in total, and the average number of reads of sequence obtained was 3.75 million per sample. With the described targeted sequencing approach on the semiconductor platform using a custom-designed library and a probabilistic statistical approach, we have demonstrated the feasibility of an alternate method of assessment for fetal T21. © 2017 S. Karger AG, Basel.

Insights into cell-free therapeutic approach: Role of stem cell "soup-ernatant".

PubMed

Raik, Shalini; Kumar, Ajay; Bhattacharyya, Shalmoli

2018-03-01

Current advances in medicine have revolutionized the field of regenerative medicine dramatically with newly evolved therapies for repair or replacement of degenerating or injured tissues. Stem cells (SCs) can be harvested from different sources for clinical therapeutics, which include fetal tissues, umbilical cord blood, embryos, and adult tissues. SCs can be isolated and differentiated into desired lineages for tissue regeneration and cell replacement therapy. However, several loopholes need to be addressed properly before this can be extended for large-scale therapeutic application. These include a careful approach for patient safety during SC treatments and tolerance of recipients. SC treatments are associated with a number of risk factors and require successful integration and survival of transplanted cells in the desired microenvironment with concurrent tissue regeneration. Recent studies have focused on developing alternatives that can replace the cell-based therapy using paracrine factors. The development of stem "cell free" therapies can be devoted mainly to the use of soluble factors (secretome), extracellular vesicles, and mitochondrial transfer. The present review emphasizes on the paradigms related to the use of SC-based therapeutics and the potential applications of a cell-free approach as an alternative to cell-based therapy in the area of regenerative medicine. © 2017 International Union of Biochemistry and Molecular Biology, Inc.

Space station needs, attributes and architectural options: Study summary

NASA Technical Reports Server (NTRS)

1983-01-01

Space station needs, attributes, and architectural options that affect the future implementation and design of a space station system are examined. Requirements for candidate missions are used to define functional attributes of a space station. Station elements that perform these functions form the basic station architecture. Alternative ways to accomplish these functions are defined and configuration concepts are developed and evaluated. Configuration analyses are carried to the point that budgetary cost estimates of alternate approaches could be made. Emphasis is placed on differential costs for station support elements and benefits that accrue through use of the station.

Medical group mergers: strategies for success.

PubMed

Latham, Will

2014-01-01

As consolidation sweeps over the healthcare industry, many medical groups are considering mergers with other groups as an alternative to employment. While mergers are challenging and fraught with risk, an organized approach to the merger process can dramatically increase the odds for success. Merging groups need to consider the benefits they seek from a merger, identify the obstacles that must be overcome to merge, and develop alternatives to overcome those obstacles. This article addresses the benefits to be gained and issues to be addressed, and provides a tested roadmap that has resulted in many successful medical group mergers.

Meta-analysis of Odds Ratios: Current Good Practices

PubMed Central

Chang, Bei-Hung; Hoaglin, David C.

2016-01-01

Background Many systematic reviews of randomized clinical trials lead to meta-analyses of odds ratios. The customary methods of estimating an overall odds ratio involve weighted averages of the individual trials’ estimates of the logarithm of the odds ratio. That approach, however, has several shortcomings, arising from assumptions and approximations, that render the results unreliable. Although the problems have been documented in the literature for many years, the conventional methods persist in software and applications. A well-developed alternative approach avoids the approximations by working directly with the numbers of subjects and events in the arms of the individual trials. Objective We aim to raise awareness of methods that avoid the conventional approximations, can be applied with widely available software, and produce more-reliable results. Methods We summarize the fixed-effect and random-effects approaches to meta-analysis; describe conventional, approximate methods and alternative methods; apply the methods in a meta-analysis of 19 randomized trials of endoscopic sclerotherapy in patients with cirrhosis and esophagogastric varices; and compare the results. We demonstrate the use of SAS, Stata, and R software for the analysis. Results In the example, point estimates and confidence intervals for the overall log-odds-ratio differ between the conventional and alternative methods, in ways that can affect inferences. Programming is straightforward in the three software packages; an appendix gives the details. Conclusions The modest additional programming required should not be an obstacle to adoption of the alternative methods. Because their results are unreliable, use of the conventional methods for meta-analysis of odds ratios should be discontinued. PMID:28169977

Simulation of a proposed emergency outlet from Devils Lake, North Dakota

USGS Publications Warehouse

Vecchia, Aldo V.

2002-01-01

From 1993 to 2001, Devils Lake rose more than 25 feet, flooding farmland, roads, and structures around the lake and causing more than $400 million in damages in the Devils Lake Basin. In July 2001, the level of Devils Lake was at 1,448.0 feet above sea level1, which was the highest lake level in more than 160 years. The lake could continue to rise to several feet above its natural spill elevation to the Sheyenne River (1,459 feet above sea level) in future years, causing extensive additional flooding in the basin and, in the event of an uncontrolled natural spill, downstream in the Red River of the North Basin as well. The outlet simulation model described in this report was developed to determine the potential effects of various outlet alternatives on the future lake levels and water quality of Devils Lake.Lake levels of Devils Lake are controlled largely by precipitation on the lake surface, evaporation from the lake surface, and surface inflow. For this study, a monthly water-balance model was developed to compute the change in total volume of Devils Lake, and a regression model was used to estimate monthly water-balance data on the basis of limited recorded data. Estimated coefficients for the regression model indicated fitted precipitation on the lake surface was greater than measured precipitation in most months, fitted evaporation from the lake surface was less than estimated evaporation in most months, and ungaged inflow was about 2 percent of gaged inflow in most months. Dissolved sulfate was considered to be the key water-quality constituent for evaluating the effects of a proposed outlet on downstream water quality. Because large differences in sulfate concentrations existed among the various bays of Devils Lake, monthly water-balance data were used to develop detailed water and sulfate mass-balance models to compute changes in sulfate load for each of six major storage compartments in response to precipitation, evaporation, inflow, and outflow from each compartment. The storage compartments--five for Devils Lake and one for Stump Lake--were connected by bridge openings, culverts, or natural channels that restricted mixing between compartments. A numerical algorithm was developed to calculate inflow and outflow from each compartment. Sulfate loads for the storage compartments first were calculated using the assumptions that no interaction occurred between the bottom sediments and the water column and no wind- or buoyancy-induced mixing occurred between compartments. However, because the fitted sulfate loads did not agree with the estimated sulfate loads, which were obtained from recorded sulfate concentrations, components were added to the sulfate mass-balance model to account for the flux of sulfate between bottom sediments and the lake and for mixing between storage compartments. Mixing between compartments can occur during periods of open water because of wind and during periods of ice cover because of water-density differences between compartments. Sulfate loads calculated using the sulfate mass-balance model with sediment interaction and mixing between compartments closely matched sulfate loads computed from historical concentrations. The water and sulfate mass-balance models were used to calculate potential future lake levels and sulfate concentrations for Devils Lake and Stump Lake given potential future values of monthly precipitation, evaporation, and inflow. Potential future inputs were generated using a scenario approach and a stochastic approach. In the scenario approach, historical values of precipitation, evaporation, and inflow were repeated in the future for a particular sequence of historical years. In the stochastic approach, a statistical time-series model was developed to randomly generate potential future inputs. The scenario approach was used to evaluate the effectiveness of various outlet alternatives, and the stochastic approach was used to evaluate the hydrologic and water-quality effects of the potential outlet alternatives that were selected on the basis of the scenario analysis. Given potential future lake levels and sulfate concentrations generated using either the scenario or stochastic approach and potential future ambient flows and sulfate concentrations for the Sheyenne River receiving waters, daily outlet discharges could be calculated for virtually any outlet alternative. For the scenario approach, future ambient flows and sulfate concentrations for the Sheyenne River were generated using the same sequence of years used for generating water-balance data for Devils Lake. For the stochastic approach, a procedure was developed for generating daily Sheyenne River flows and sulfate concentrations that were "in-phase" with the generated water-balance data for Devils Lake. Simulation results for the scenario approach indicated that neither of the West Bay outlet alternatives provided effective flood-damage reduction without exceeding downstream water-quality constraints. However, both Pelican Lake outlet alternatives provided significant flood-damage reduction with only minor downstream water-quality changes. The most effective alternative for controlling rising lake levels was a Pelican Lake outlet with a 480-cubic-foot-per-second pump capacity and a 250-milligram-per-liter downstream sulfate constraint. However, this plan is costly because of the high pump capacity and the requirement of a control structure on Highway 19 to control the level of Pelican Lake. A less costly, though less effective for flood-damage reduction, plan is a Pelican Lake outlet with a 300-cubic-foot-per-second pump capacity and a 250-milligram-per-liter downstream sulfate constraint. The plan is less costly because the pump capacity is smaller and because the control structure on Highway 19 is not required. The less costly Pelican Lake alternative with a 450-milligramper- liter downstream sulfate constraint rather than a 250-milligram-per-liter downstream sulfate constraint was identified by the U.S. Army Corps of Engineers as the preferred alternative for detailed design and engineering analysis. Simulation results for the stochastic approach indicated that the geologic history of lake-level fluctuations of Devils Lake for the past 2,500 years was consistent with a climatic history that consisted of two climate states--a wet state, similar to conditions during 1980-99, and a normal state, similar to conditions during 1950-78. The transition times between the wet and normal climatic periods occurred randomly. The average duration of the wet climatic periods was 20 years, and the average duration of the normal climatic periods was 120 years. The stochastic approach was used to generate 10,000 independent sequences of lake levels and sulfate concentrations for Devils Lake for water years 2001-50. Each trace began with the same starting conditions, and the duration of the current wet cycle was generated randomly for each trace. Each trace was generated for the baseline (natural) condition and for the Pelican Lake outlet with a 300-cubic-foot-per-second pump capacity and a 450-milligram-per-liter downstream sulfate constraint. The outlet significantly lowered the probabilities of future lake-level increases within the next 50 years and did not substantially increase the probabilities of reaching low lake levels or poor water-quality conditions during the same period.

The Most Economic, Socially Viable, and Environmentally Sustainable Alternative Energy

ERIC Educational Resources Information Center

Vanderburg, Willem H.

2008-01-01

The strengths and weaknesses of current energy planning can be attributed to the limited economic, social, and environmental contexts taken into account as a result of the current intellectual and professional division of labor. A preventive approach is developed by which the ratio of desired to undesired effects can be substantially improved. It…

Assessment of equine waste as a biomass resource in New York State

USDA-ARS?s Scientific Manuscript database

Equine operations may generate excessive quantities of biomass (manure and used bedding) that could either become a waste or a resource, especially when the biomass is developed as an alternative energy source. Using the generated biomass as a resource can involve a variety of approaches such as la...