Development of a Structured Undergraduate Research Experience: Framework and Implications

ERIC Educational Resources Information Center

Brown, Anne M.; Lewis, Stephanie N.; Bevan, David R.

2016-01-01

Participating in undergraduate research can be a pivotal experience for students in life science disciplines. Development of critical thinking skills, in addition to conveying scientific ideas in oral and written formats, is essential to ensuring that students develop a greater understanding of basic scientific knowledge and the research process.…

Business Mathematics Curriculum Guide.

ERIC Educational Resources Information Center

Ebersole, Benjamin P., Comp.; And Others

This revised course in business mathematics emphasizes computations needed for problem solving, but greater attention is focused on mathematical principles that were developed in previous grades. In addition, the course aims to develop further an understanding of business principles and practices which can be used in gainful employment and in the…

Future Mission Trends and their Implications for the Deep Space Network

NASA Technical Reports Server (NTRS)

Abraham, Douglas S.

2006-01-01

Planning for the upgrade and/or replacement of Deep Space Network (DSN) assets that typically operate for forty or more years necessitates understanding potential customer needs as far into the future as possible. This paper describes the methodology Deep Space Network (DSN) planners use to develop this understanding, some key future mission trends that have emerged from application of this methodology, and the implications of the trends for the DSN's future evolution. For NASA's current plans out to 2030, these trends suggest the need to accommodate: three times as many communication links, downlink rates two orders of magnitude greater than today's, uplink rates some four orders of magnitude greater, and end-to-end link difficulties two-to-three orders of magnitude greater. To meet these challenges, both DSN capacity and capability will need to increase.

Students' Understanding of the Nature of Matter and Chemical Reactions--A Longitudinal Study of Conceptual Restructuring

ERIC Educational Resources Information Center

Øyehaug, Anne Bergliot; Holt, Anne

2013-01-01

This longitudinal study aims to provide greater insight into how students' understanding of matter and chemical reactions develops over time and how their knowledge structures are restructured. Four case-study students in a Norwegian primary school were followed for two years from age 10-11 to age 12-13. Researchers were responsible for…

Parent-Child Play across Cultures: Advancing Play Research

ERIC Educational Resources Information Center

Roopnarine, Jaipaul L.; Davidson, Kimberly L.

2015-01-01

In this article, the authors argue for a greater understanding of children's play across cultures through better integration of scientific thinking about the developed and developing societies, through consideration of socialization beliefs and goals, and, finally, through the use of more complex models in research investigations. They draw on…

School Leadership Skill Development

ERIC Educational Resources Information Center

Weigel, Richard A.

2013-01-01

The purpose of this study was to investigate the relationship between what is currently understood about skills for school leadership and the need for a greater understanding of those skills. The importance of developing leadership skills to improve school performance and effectiveness is great. In the field of school leadership, most leaders…

The Development of Embodied Representations of Numerical Understanding through Gameplay

ERIC Educational Resources Information Center

Clark, Colin Travis

2012-01-01

Young children must develop basic concepts of numeracy--one being that numbers have magnitudes that increase linearly--before they are able to succeed in mathematics. Children from low-income families have been found to be at a greater disadvantage in the development of numeracy, but this disadvantage can be overcome through the use of a simple…

Revisit, revamp and revitalize your business plan: part 1.

PubMed

Waldron, David

2011-01-01

The diagnostic imaging department has a pivotal role within the hospital and its pillar services. Understanding this role and also understanding the population served helps to further define and justify the "what" and "why" of the business plan. Understand the market capacity and how market needs can be satisfied. Develop a "go-to-market" strategy, which is the part of the business plan where it is decided how to share that message with the market. In the aftermath of healthcare reform and the economic recession, investing in new imaging technology has never been under greater scrutiny. A three step process for developing support is provided.

An agent-based model of tsetse fly response to seasonal climatic drivers: Assessing the impact on sleeping sickness transmission rates.

PubMed

Alderton, Simon; Macleod, Ewan T; Anderson, Neil E; Palmer, Gwen; Machila, Noreen; Simuunza, Martin; Welburn, Susan C; Atkinson, Peter M

2018-02-01

This paper presents the development of an agent-based model (ABM) to incorporate climatic drivers which affect tsetse fly (G. m. morsitans) population dynamics, and ultimately disease transmission. The model was used to gain a greater understanding of how tsetse populations fluctuate seasonally, and investigate any response observed in Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) disease transmission, with a view to gaining a greater understanding of disease dynamics. Such an understanding is essential for the development of appropriate, well-targeted mitigation strategies in the future. The ABM was developed to model rHAT incidence at a fine spatial scale along a 75 km transect in the Luangwa Valley, Zambia. The model incorporates climatic factors that affect pupal mortality, pupal development, birth rate, and death rate. In combination with fine scale demographic data such as ethnicity, age and gender for the human population in the region, as well as an animal census and a sample of daily routines, we create a detailed, plausible simulation model to explore tsetse population and disease transmission dynamics. The seasonally-driven model suggests that the number of infections reported annually in the simulation is likely to be a reasonable representation of reality, taking into account the high levels of under-detection observed. Similar infection rates were observed in human (0.355 per 1000 person-years (SE = 0.013)), and cattle (0.281 per 1000 cattle-years (SE = 0.025)) populations, likely due to the sparsity of cattle close to the tsetse interface. The model suggests that immigrant tribes and school children are at greatest risk of infection, a result that derives from the bottom-up nature of the ABM and conditioning on multiple constraints. This result could not be inferred using alternative population-level modelling approaches. In producing a model which models the tsetse population at a very fine resolution, we were able to analyse and evaluate specific elements of the output, such as pupal development and the progression of the teneral population, allowing the development of our understanding of the tsetse population as a whole. This is an important step in the production of a more accurate transmission model for rHAT which can, in turn, help us to gain a greater understanding of the transmission system as a whole.

Understanding the Relationship Between Food Variety, Food Intake, and Energy Balance.

PubMed

Raynor, Hollie A; Vadiveloo, Maya

2018-03-01

In accordance with US dietary guidance, incorporating variety into the diet can align with energy balance, though greater food variety in some categories may make energy balance more challenging. Thus, experimental and epidemiologic evidence is summarized on the relationship between food variety, food and energy intake, and energy balance. Lab-based, experimental research consistently demonstrates that greater variety within foods or sensory characteristics of food increases food and energy intake within an eating occasion. Epidemiologic evidence is less consistent, potentially driven by differing methodologies, particularly in defining and measuring food variety. Moreover, the effect of variety on energy balance appears to be moderated by food energy density. Integrating insights from experimental and epidemiologic research are essential for strengthening food variety guidance including developing evidence-based definitions of food variety, understanding moderators of the relationship, and developing practical guidance interpretable to consumers.

A Closer Look at the Camp Experience: Examining Relationships between Life Skills, Elements of Positive Youth Development, and Antecedents of Change among Camp Alumni

ERIC Educational Resources Information Center

Garst, Barry A.; Gagnon, Ryan J.; Whittington, Anja

2016-01-01

Understanding program components that contribute to positive youth outcomes following camp experiences can help program providers bring a greater level of intentionality to their efforts. The purposes of this study were twofold: (a) to develop reliable and valid measures of life skill development, elements of positive youth development (PYD), and…

FY 2002 Report on Software Visualization Techniques for IV and V

NASA Technical Reports Server (NTRS)

Fotta, Michael E.

2002-01-01

One of the major challenges software engineers often face in performing IV&V is developing an understanding of a system created by a development team they have not been part of. As budgets shrink and software increases in complexity, this challenge will become even greater as these software engineers face increased time and resource constraints. This research will determine which current aspects of providing this understanding (e.g., code inspections, use of control graphs, use of adjacency matrices, requirements traceability) are critical to the performing IV&V and amenable to visualization techniques. We will then develop state-of-the-art software visualization techniques to facilitate the use of these aspects to understand software and perform IV&V.

Valuing the Environment, K-6.

ERIC Educational Resources Information Center

Charlotte-Mecklenburg Public Schools, Charlotte, NC.

This guide was developed for use in grades K-6 as an enrichment program based on clarifying values. The program, designed by teachers, aims to develop in the student a greater awareness and understanding of the community, themselves, and the earth. The program includes a number of environmental encounters. Topical themes lead teachers and students…

Human Development and Violence Prevention: A Focus on Youth. Center Paper 011.

ERIC Educational Resources Information Center

Williams, Kirk R.; Guerra, Nancy G.; Elliott, Delbert S.

This publication outlines a theoretical framework to guide research, policy, and action plans to combat youth violence. Research findings suggest that analyzing violence in connection with human development will provide a greater understanding of the problem. Such an analysis should trace pathways to violence in order to infuse prevention…

Investigating Learning through Work: The Development of the "Provider Learning Environment Scale"

ERIC Educational Resources Information Center

Chappell, Clive; Hawke, Geof

2008-01-01

The purpose of this research activity was to investigate contemporary understandings of the connections between learning and work. This initial work was then used to inform the development of an organisational tool that registered training organisations (RTOs) could use to identify organisational practices likely to lead to greater learning at…

Firm size diversity, functional richness, and resilience

USGS Publications Warehouse

Garmestani, A.S.; Allen, Craig R.; Mittelstaedt, J.D.; Stow, C.A.; Ward, W.A.

2006-01-01

This paper applies recent advances in ecology to our understanding of firm development, sustainability, and economic development. The ecological literature indicates that the greater the functional richness of species in a system, the greater its resilience - that is, its ability to persist in the face of substantial changes in the environment. This paper focuses on the effects of functional richness across firm size on the ability of industries to survive in the face of economic change. Our results indicate that industries with a richness of industrial functions are more resilient to employment volatility. ?? 2006 Cambridge University Press.

A Constructivist Cloud Lab.

ERIC Educational Resources Information Center

Emery, Dave

1996-01-01

Describes a lab involving a cloud formation activity that uses the constructivist learning model to get students more involved in creating the lab. Enables students to develop a greater understanding of the concepts involved and more interest in the lab's outcomes. (JRH)

The effects of early auditory-based intervention on adult bilateral cochlear implant outcomes.

PubMed

Lim, Stacey R

2017-09-01

The goal of this exploratory study was to determine the types of improvement that sequentially implanted auditory-verbal and auditory-oral adults with prelingual and childhood hearing loss received in bilateral listening conditions, compared to their best unilateral listening condition. Five auditory-verbal adults and five auditory-oral adults were recruited for this study. Participants were seated in the center of a 6-loudspeaker array. BKB-SIN sentences were presented from 0° azimuth, while multi-talker babble was presented from various loudspeakers. BKB-SIN scores in bilateral and the best unilateral listening conditions were compared to determine the amount of improvement gained. As a group, the participants had improved speech understanding scores in the bilateral listening condition. Although not statistically significant, the auditory-verbal group tended to have greater speech understanding with greater levels of competing background noise, compared to the auditory-oral participants. Bilateral cochlear implantation provides individuals with prelingual and childhood hearing loss with improved speech understanding in noise. A higher emphasis on auditory development during the critical language development years may add to increased speech understanding in adulthood. However, other demographic factors such as age or device characteristics must also be considered. Although both auditory-verbal and auditory-oral approaches emphasize spoken language development, they emphasize auditory development to different degrees. This may affect cochlear implant (CI) outcomes. Further consideration should be made in future auditory research to determine whether these differences contribute to performance outcomes. Additional investigation with a larger participant pool, controlled for effects of age and CI devices and processing strategies, would be necessary to determine whether language learning approaches are associated with different levels of speech understanding performance.

Growing children's bodies and minds: maximizing child nutrition and development.

PubMed

Engle, Patrice; Huffman, Sandra L

2010-06-01

For their optimal growth, and for greater long-term human capital development, children profit not only from improved nutrition but also from improved learning opportunities in the earliest years of life. This paper describes how actions to enhance optimal infant and young child nutrition can be linked with child development interventions for children under 3 years of age. In countries with high rates of malnutrition, linking these two components will result in synergies of program activities, and will bring about a greater impact at reduced cost than either activity conducted separately. New understanding of social marketing and communication strategies can increase effectiveness of linked interventions. Public-private partnerships to improve both child development and nutrition offer promise for sustainable interventions.

White pine pruning and branch growth

Treesearch

Thomas W. McConkey

1965-01-01

A better understanding of the growth responses of young trees to silvicultural treatments is essential for intensive management programs for juvenile stands. At the juvenile stage, the effect of silvicultural treatment on main-stem development is much greater than it would be later.

Dream Chasers: An Exploration of How Role Identity Is Related to Career Development Attitudes among African American Male Collegiate Athletes

ERIC Educational Resources Information Center

Small, Charles Lamar

2013-01-01

In order to develop an identity, individuals undergo the process of role-taking. During this process, they slowly develop an identity as they gain greater comprehension of social meanings in the culture. The individual is able to assume the group culture or perspective as they interact with others and better understand their role in those…

How Educational Leaders Learn to Develop Strategy for Their Institution: A Case Study

ERIC Educational Resources Information Center

VanDenBerghe, Claire L.

2010-01-01

The purpose of this research study was to acquire greater insight into how educational leaders learn to develop strategies for their institution. Through a better understanding of the process by which such learning occurs, the researcher sought to uncover the factors that facilitate or impede these learning opportunities, particularly with regard…

Evaluating Academic Development in the Higher Education Sector: Academic Developers' Reflections on Using a Toolkit Resource

ERIC Educational Resources Information Center

Winter, Jennie; Turner, Rebecca; Spowart, Lucy; Muneer, Reema; Kneale, Pauline

2017-01-01

The professionalisation of teaching is of increasing importance in UK higher education due to converging processes including the proliferation of managerialism, increasing quality agendas and changes to student fee structures. These have brought into sharp relief the need for greater understanding of how quality teaching evolves in university…

Training Manual: NSDC's Standards for Staff Development [CD-ROM

ERIC Educational Resources Information Center

Roy, Patricia

2006-01-01

This 60-page guidebook presents a plan for a one-day workshop to introduce NSDC's standards to educators. The sessions are designed to encourage participant involvement to develop greater understanding of the standards. The slide presentation plus materials needed to conduct activities are included as PDF files on a CD-ROM. This guidebook may be…

Family Life and Human Development. Senior High School Semester Elective.

ERIC Educational Resources Information Center

Montgomery County Public Schools, Rockville, MD.

This document is a curriculum guide for a family life and human development course to be used as a senior high school elective. The purpose of the course is to help students gain a greater understanding of human sexuality and to obtain information needed for intelligent, responsible decision making. Thirteen units included in the course are…

The impact of professional development on classroom teaching for science educators participating in a long term community of practice

NASA Astrophysics Data System (ADS)

Jensen, Aaron C.

Efforts to modify and improve science education in the United States have seen minimal success (Crawford, 2000; Borko & Putman, 1996; Puntambekar, Stylianou & Goldstein, 2007; Lustick, 2011). One important reason for this is the professional development that teachers go through in order to learn about and apply these new ideas is generally of poor quality and structured incorrectly for long-term changes in the classroom (Little, 1993; Fullen, 1996; Porter, 2000; Jeanpierre, Oberhauser, & Freeman, 2005). This grounded theory study explores a science community of practice and how the professional development achieved through participation in that community has effected the instruction of the teachers involved, specifically the incorporation of researched based effective science teaching instructional strategies. This study uses personal reflection papers written by the participants, interviews, and classroom observations to understand the influence that the science community of practice has had on the participants. Results indicate that participation in this science community of practice has significant impact on the teachers involved. Participants gained greater understanding of science content knowledge, incorporated effective science instructional strategies into their classroom, and were able to practice both content knowledge and strategies in a non-threatening environment thus gaining a greater understanding of how to apply them in the classrooms. These findings motivate continued research in the role that communities of practice may play in teacher professional develop and the effectiveness of quality professional development in attaining long-term, sustained improvement in science education.

Using the Conceptual Change Instruction To Improve Learning.

ERIC Educational Resources Information Center

Alparslan, Cem; Tekkaya, Ceren; Geban, Omer

2003-01-01

Investigates the effect of conceptual change instruction on grade 11 students' understanding of respiration. The Respiration Concept Test was developed and used to test students' misconceptions. Results indicate that the conceptual change instruction that explicitly addressed students' misconceptions produced significantly greater achievement in…

Is Quaternary geology ready for the future?

NASA Astrophysics Data System (ADS)

Ritter, Dale F.

1996-07-01

Armed with a better understanding of process and an array of developing dating techniques, Quaternary geology is poised to achieve greater recognition in the general scientific community. This recognition however, will require some thought adjustment. Quaternary geologists will have to convince government, industry and a variety of scientific groups that they possess unique training and expertise that is needed as part of the thrust to fully understand and/or resolve major scientific problems. Therefore, future research and education efforts should not focus on developing a rigidly defined identity within geoscience, but instead should seek ways to be integrated with interdisciplinary teams that will investigate complex environmental and climate change problems. Such a scenaria creates and enermous dilemma for Quaternary geologists because they will derive greater intellectual stimulation from scientists working in discplines other than geology, and their scientific collaboratiors will most likely not be their academic colleagues. This outward expansion of our scientific network will require the development of interdsciplinary research collaboration and/or degree-granting programs at the graduate level. To accomplish such goals, universities must resist "turf protection", and funding agencies muts become more efficient at facilitating interdisciplinary research.

Cultural Differences in Donation Decision-Making.

PubMed

Wang, Yan; Tang, Yi-Yuan; Wang, Jinjun

2015-01-01

Decisions to help those in need are essential for human development and survival. Previous studies have demonstrated the "identified effect", in which one identifiable individual typically invokes stronger feelings of compassion and receives greater aid than statistical victim. However, this preference might be influenced by cultural differences. In the current study, Chinese respondents' ratings of distress and sympathy and their willingness to contribute are greater for a group of sick children than an individual. In the U.S., greater willingness to help and sympathy are elicited by an identified victim in comparison with an unidentified one. The different results may demonstrate the importance of cultural differences when trying to understand people's prosocial behavior.

Suicidal and online: how do online behaviors inform us of this high-risk population?

PubMed

Harris, Keith M; McLean, John P; Sheffield, Jeanie

2014-01-01

To assist suicide prevention we need a better understanding of how suicidal individuals act in their environment, and the online world offers an ideal opportunity to examine daily behaviors. This anonymous survey (N = 1,016) provides first-of-its-kind empirical evidence demonstrating suicide-risk people (n = 290) are unique in their online behaviors. Suicidal users reported more time online, greater likelihood of developing online personal relationships, and greater use of online forums. In addition, suicide-risk women reported more time browsing/surfing and social networking. The authors conclude that suicide prevention efforts should respond to suicide-risk users' greater demands for online interpersonal communications.

On the interaction of ultrasound with cracks: Applications to fatigue crack growth

NASA Technical Reports Server (NTRS)

Buck, O.; Thompson, R. B.; Rehbein, D. K.

1986-01-01

Partial contact of two rough fatigue crack surfaces leads to transmission and diffraction of an acoustic signal at those contacts. Recent experimental and theoretical efforts to understand and quantify such contact in greater detail are discussed. The objective is to develop an understanding of the closure phenomenon and its application to the interpretation of fatigue data, in particular the R-ratio, spike overload/underload and threshold effects on crack propagation.

Theory of Mind and Emotion Understanding Predict Moral Development in Early Childhood

PubMed Central

Lane, Jonathan D.; Wellman, Henry M.; Olson, Sheryl L.; LaBounty, Jennifer; Kerr, David C. R.

2011-01-01

The current study utilized longitudinal data to investigate how theory of mind (ToM) and emotion understanding (EU) concurrently and prospectively predicted young children’s moral reasoning and decision-making. One hundred twenty-eight children were assessed on measures of ToM and EU at 3.5 years- and 5.5 years-of-age. At 5.5 years, children were also assessed on the quality of moral reasoning and decision-making they used to negotiate prosocial moral dilemmas, in which the needs of a story protagonist conflict with the needs of another story character. More sophisticated EU predicted greater use of physical- and material-needs reasoning, and a more advanced ToM predicted greater use of psychological-needs reasoning. Most intriguing, ToM and EU jointly predicted greater use of higher-level acceptance-authority reasoning, which is likely a product of children’s increasing appreciation for the knowledge held by trusted adults and children’s desire to behave in accordance with social expectations. PMID:21121472

Theory of mind and emotion understanding predict moral development in early childhood.

PubMed

Lane, Jonathan D; Wellman, Henry M; Olson, Sheryl L; LaBounty, Jennifer; Kerr, David C R

2010-11-01

The current study utilized longitudinal data to investigate how theory of mind (ToM) and emotion understanding (EU) concurrently and prospectively predicted young children's moral reasoning and decision making. One hundred twenty-eight children were assessed on measures of ToM and EU at 3.5 and 5.5 years of age. At 5.5 years, children were also assessed on the quality of moral reasoning and decision making they used to negotiate prosocial moral dilemmas, in which the needs of a story protagonist conflict with the needs of another story character. More sophisticated EU predicted greater use of physical- and material-needs reasoning, and a more advanced ToM predicted greater use of psychological-needs reasoning. Most intriguing, ToM and EU jointly predicted greater use of higher-level acceptance-authority reasoning, which is likely a product of children's increasing appreciation for the knowledge held by trusted adults and children's desire to behave in accordance with social expectations.

13th Annual Systems Engineering Conference: Tues- Wed

DTIC Science & Technology

2010-10-28

greater understanding/documentation of lessons learned – Promotes SE within the organization • Justification for continued funding of SE Infrastructure...educational process – Addresses the development of innovative learning tools, strategies, and teacher training • Research and Development – Promotes ...technology, and mathematics • More commitment to engaging young students in science, engineering, technology and mathematics • More rigor in defining

Guide for Teaching the Novel "Island of the Blue Dolphins," Grade 6.

ERIC Educational Resources Information Center

Prior, Kathleen W.

As a guide for in-depth study of "Island of the Blue Dolphins" by sixth-graders who have completed the basal reader, this document focuses on ways of enabling each child to find satisfaction and enjoyment in the novel; to develop a greater interest in literature; to gain an understanding of plot development in a story; to realize what…

Techniques for Small-Group Discourse

ERIC Educational Resources Information Center

Kilic, Hulya; Cross, Dionne I.; Ersoz, Filyet A.; Mewborn, Denise S.; Swanagan, Diana; Kim, Jisun

2010-01-01

The nature of mathematical discourse and its influence on the development of students' mathematical understanding has received much attention from researchers in recent years. Engaging students in discursive practices can be difficult; teachers can increase their competence in facilitating discourse through greater awareness of the impact of…

Helping to Solve the Energy Problem through In-Service Training.

ERIC Educational Resources Information Center

Farnsworth, Briant J.; Gardner, Janet

1978-01-01

Granite School District has developed energy in-service training for teachers. The goal was to infuse energy concepts into the regular school curriculum. When part of the curriculum, this program provides students with greater understanding of the energy problem and possible solutions. (Author)

What Librarians Need to Know to Survive in an Age of Technology.

ERIC Educational Resources Information Center

Malinconico, S. Michael

1992-01-01

Discusses the changing library environment, with greater reliance on technology; and describes relevant skills for librarians, including communicating with nonlibrarians, working with group processes, understanding the capabilities of information-handling technologies, and developing management and marketing abilities. (21 references) (EA)

Alida Gerritsen | NREL

Science.gov Websites

research, such as proteomics and metabolomics, in order to develop a greater understanding of the organisms used for renewable energy resources. Research Interests Bioinformatics Novel analysis pipelines Education Ph.D., Evolutionary Biology, University of Oregon B.S., Biology, St. Lawrence University

The Development of Curricula/Programs for Indian and Metis People.

ERIC Educational Resources Information Center

Whyte, Kenn

1982-01-01

Discusses various multicultural education programs in Canada, recommending an understanding and appreciation of cultural heritage, analysis of contemporary conditions, and flexibility, variability, and greater control by minority groups of educational processes. Available: Department of Educational Foundations, 5-109 Education North, University of…

Update: the role of FoxP3 in allergic disease.

PubMed

Paik, Young; Dahl, Matthew; Fang, Deyu; Calhoun, Karen

2008-06-01

T-regulatory cells play a key role in allergic and asthmatic inflammatory airway diseases. This review discusses the importance of a critical gene associated with T-regulatory cells. Forkhead box P3 is a forkhead-winged helix transcription factor gene involved in immune function in allergy and asthma. Recently, many functions of forkhead box P3 and its influence on the immune system have been elucidated. T-regulatory cells that are CD4+CD25+ and express forkhead box P3, influence the development and expression of atopy and allergic response. The exact mechanisms are not yet delineated, but multiple recent studies provide greater understanding of the mechanism of forkhead box P3 and its influence on these T-regulatory cells. Greater understanding of the molecular and immunological mechanisms underlying the T-regulatory cells and forkhead box P3 will permit the development of targeted treatment modalities to influence disease processes such as allergic rhinitis and bronchial asthma.

Reading Takes You around the World.

ERIC Educational Resources Information Center

Scott, Jane

1998-01-01

Describes an elementary school's reading-incentive program, based on a travel theme, that was developed to promote greater understanding of diverse cultures, to increase knowledge of world geography, and to encourage independent reading. Topics include motivation, parent involvement, public-library help, and increased use of the library's…

Historical Research: A Lens for Family and Consumer Sciences

ERIC Educational Resources Information Center

Nickols, Sharon Y.

2017-01-01

This article describes various historical research methods and presents examples of their application in family and consumer sciences (FCS). Historical research preserves the heritage of FCS through greater understanding of the development of the field and practitioners of the profession. Furthermore, historical research can revitalize…

Structure, Agency, Complexity Theory and Interdisciplinary Research in Education Studies

ERIC Educational Resources Information Center

Smith, John A.

2013-01-01

This article argues that Education Studies needs to develop its existing interdisciplinarity understanding of structures and agencies by giving greater attention to the modern process theories of self-organisation in the physical, biological, psychological and social sciences, sometimes given the umbrella term "complexity theory". The…

Organizational Diagnosis: Its Role in Organizational Learning.

ERIC Educational Resources Information Center

Beer, Michael; Spector, Bert

1993-01-01

Sees diagnosis as process that helps organizations enhance their capacity to assess and change dysfunctional aspects of culture and patterns of behavior as basis for developing greater effectiveness and ensuring continuous improvement. Presents framework for understanding "learning diagnosis" in which diagnostic process is part of large-scale…

Working Together

ERIC Educational Resources Information Center

Sullivan, Margaret

2010-01-01

Students need space to gather, share ideas, talk, develop common understanding and work to create greater knowledge. This focus on collaboration has put a strain on group study spaces. Students need to collaborate spontaneously, and scheduling time in a study room is not conducive to spur-of-the-moment collaboration. At many education…

Memorandum of understanding between the Department of Homeland Security and the Department of Transportation on roles and responsibilities.

DOT National Transportation Integrated Search

2004-01-01

The purpose of this MOU is to facilitate the development and deployment of transportation securty measures that consider efficiency in the movement of goods and people at the same time that they engender greater safety and security.

An Assessment of Commuter Aircraft Noise Impact

NASA Technical Reports Server (NTRS)

Fidell, Sanford; Pearsons, Karl S.; Silvati, Laura; Sneddon, Matthew

1996-01-01

This report examines several approaches to understanding 'the commuter aircraft noise problem.' The commuter aircraft noise problem in the sense addressed in this report is the belief that some aspect(s) of community response to noise produced by commuter aircraft operations may not be fully assessed by conventional environmental noise metrics and methods. The report offers alternate perspectives and approaches for understanding this issue. The report also develops a set of diagnostic screening questions; describes commuter aircraft noise situations at several airports; and makes recommendations for increasing understanding of the practical consequences of greater heterogeneity in the air transport fleet serving larger airports.

The Role of the Medical Provider in the Evaluation of Sexually Abused Children and Adolescents

ERIC Educational Resources Information Center

Newton, Alice Whittier; Vandeven, Andrea Marie

2010-01-01

It was only 30 years ago that the medical community began to develop an increased awareness of child sexual abuse, and the role of the medical provider in the evaluation of sexually abused children has evolved significantly. As clinicians worldwide develop a greater understanding of the impact of the sexual abuse evaluation on the child, the roles…

Cultural Differences in Donation Decision-Making

PubMed Central

Wang, Jinjun

2015-01-01

Decisions to help those in need are essential for human development and survival. Previous studies have demonstrated the “identified effect”, in which one identifiable individual typically invokes stronger feelings of compassion and receives greater aid than statistical victim. However, this preference might be influenced by cultural differences. In the current study, Chinese respondents’ ratings of distress and sympathy and their willingness to contribute are greater for a group of sick children than an individual. In the U.S., greater willingness to help and sympathy are elicited by an identified victim in comparison with an unidentified one. The different results may demonstrate the importance of cultural differences when trying to understand people’s prosocial behavior. PMID:26372014

Winning Women into Mathematics.

ERIC Educational Resources Information Center

Kenschaft, Patricia Clark, Ed.; Keith, Sandra Zaroodny, Ed.

Mathematics is an auspicious discipline for young people of both sexes and all ethnic groups. This booklet aims to help members of the Mathematical Association of America (MAA) and others to increase future participation of women in mathematics, to better understand their present roles, and to develop a vision of a world with greater equal…

75 FR 6689 - Sustainable Communities Planning Grant Program Advance Notice and Request for Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... greater and more broad-based support of community development and investment decisions. However, these... and to expand opportunities for stakeholders to engage in decision-making, HUD is seeking comments on... its partners to better understand how this Program can support cooperative regional planning efforts...

Is It Counting, or Is It Adding?

ERIC Educational Resources Information Center

Eisenhardt, Sara; Fisher, Molly H.; Thomas, Jonathan; Schack, Edna O.; Tassell, Janet; Yoder, Margaret

2014-01-01

The Common Core State Standards for Mathematics (CCSSI 2010) expect second grade students to "fluently add and subtract within 20 using mental strategies" (2.OA.B.2). Most children begin with number word sequences and counting approximations and then develop greater skill with counting. But do all teachers really understand how this…

Experiencing Organizational Work Design: Beyond Hackman and Oldham

ERIC Educational Resources Information Center

Fornaciari, Charles J.; Dean, Kathy Lund

2005-01-01

Standard organizational behavior survey courses usually introduce students to the "nuts and bolts" of organizational work design and models that mechanize work. This article develops an experiential exercise that simulates working conditions that can foster greater student understanding of the affective, ethical, and human aspects of work design.…

Using Number Sense to Compare Fractions

ERIC Educational Resources Information Center

Bray, Wendy S.; Abreu-Sanchez, Laura

2010-01-01

One mathematical focus for third graders is to develop deep understanding of fractions and fraction equivalence, including comparing fractions through use of models and reasoning strategies. Before reading further, consider how you might solve the following problem: Which fraction is greater, 14/24 or 17/36? The initial impulse of many adults is…

Evolution: Don't Debate, Educate.

ERIC Educational Resources Information Center

Bybee, Rodger W.

2000-01-01

Discusses controversy over the teaching of biological evolution and other scientific ideas such as Big Bang theory. Recommends that teachers avoid debating creationists, help students develop a greater understanding and appreciation for science as a way of explaining the natural world, and emphasize inquiry and the nature of science. (Contains 19…

Alcoholism: Development, Consequences, and Interventions.

ERIC Educational Resources Information Center

Estes, Nada J.; Heinemann, M. Edith

This book is intended to contribute to the theoretical knowledge of alcoholism workers so that the needs of people with alcohol related problems may be met with greater understanding. Contributors to the book represent a variety of disciplines and address a broad spectrum of topics. Part One deals with developmental perspectives of alcoholism,…

A Study of Motherhood and Perceived Career Satisfaction of Women in Student Affairs

ERIC Educational Resources Information Center

Snyder, Kacee Ferrell

2011-01-01

There is limited research available on the relationship between motherhood and career satisfaction. This dissertation examined women who worked as student affairs professionals to develop a greater understanding of the relationship between motherhood and career satisfaction. The following research questions were addressed: Is there a difference…

Hispanic Parent Involvement in Early Childhood Programs. ERIC Digest.

ERIC Educational Resources Information Center

Espinosa, Linda M.

To determine effective strategies for connecting Hispanic parents and their children's early childhood programs, educators need to develop a greater understanding of the features of the Hispanic culture that influence parents' childrearing practices and orientation toward formal education. Educators should be aware of Hispanics' diversity in terms…

Teaching about Religion in the Social Studies Curriculum.

ERIC Educational Resources Information Center

Valk, John

1998-01-01

Discusses the historical shift from teaching religion to teaching about religion. Calls for teachers to develop a greater understanding of religious diversity, its role in shaping lives, and the effect it has on historical change. Offers suggestions and resources designed to assist social studies educators to teach meaningfully about religion.…

Adapting Books: Ready, Set, Read!: EAT: Equipment, Adaptations, and Technology

ERIC Educational Resources Information Center

Schoonover, Judith; Norton-Darr, Sally

2016-01-01

Developing multimodal materials to introduce or extend literacy experiences sets the stage for literacy success. Alternative ways to organize, display and arrange, interact and respond to information produces greater understanding of concepts. Adaptations include making books easier to use (turning pages or holding), and text easier to read…

Alternatives--One Approach to Drug Education.

ERIC Educational Resources Information Center

Dohner, V. Alton

This publication attempts to produce greater understanding of the complex problems of drug abuse and drug dependence. The major emphasis for prevention is through helping children develop to a healthy maturity. Section One discusses various approaches to drug education (scare and fear, matter-of-fact, styles of use and motives, society and…

Development of an aerodynamic measurement system for hypersonic rarefied flows

NASA Astrophysics Data System (ADS)

Ozawa, T.; Fujita, K.; Suzuki, T.

2015-01-01

A hypersonic rarefied wind tunnel (HRWT) has lately been developed at Japan Aerospace Exploration Agency in order to improve the prediction of rarefied aerodynamics. Flow characteristics of hypersonic rarefied flows have been investigated experimentally and numerically. By conducting dynamic pressure measurements with pendulous models and pitot pressure measurements, we have probed flow characteristics in the test section. We have also improved understandings of hypersonic rarefied flows by integrating a numerical approach with the HRWT measurement. The development of the integration scheme between HRWT and numerical approach enables us to estimate the hypersonic rarefied flow characteristics as well as the direct measurement of rarefied aerodynamics. Consequently, this wind tunnel is capable of generating 25 mm-core flows with the free stream Mach number greater than 10 and Knudsen number greater than 0.1.

Understanding Infusion Pumps.

PubMed

Mandel, Jeff E

2018-04-01

Infusion systems are complicated electromechanical systems that are used to deliver anesthetic drugs with moderate precision. Four types of systems are described-gravity feed, in-line piston, peristaltic, and syringe. These systems are subject to a number of failure modes-occlusion, disconnection, siphoning, infiltration, and air bubbles. The relative advantages of the various systems and some of the monitoring capabilities are discussed. A brief example of the use of an infusion system during anesthetic induction is presented. With understanding of the functioning of these systems, users may develop greater comfort.

Globalization, culture and psychology.

PubMed

Melluish, Steve

2014-10-01

This article outlines the cultural and psychological effects of globalization. It looks at the impact of globalization on identity; ideas of privacy and intimacy; the way we understand and perceive psychological distress; and the development of the profession of psychology around the world. The article takes a critical perspective on globalization, seeing it as aligned with the spread of neoliberal capitalism, a tendency towards cultural homogenization, the imposition of dominant 'global north' ideas and the resultant growing inequalities in health and well-being. However, it also argues that the increased interconnectedness created by globalization allows for greater acknowledgement of our common humanity and for collective efforts to be developed to tackle what are increasingly global problems. This requires the development of more nuanced understandings of cultural differences and of indigenous psychologies.

Approaching patient engagement in research: what do patients with cardiovascular disease think?

PubMed

Finney Rutten, Lila J; Morris, Megan A; Schrader, Lisa M; Manemann, Sheila M; Pathak, Jyotishman; Dimler, Robert; Roger, Veronique L

2015-01-01

Movement toward patient-centered health care must be supported by an evidence base informed by greater patient engagement in research. Efforts to better understand patients' interest in and perspectives on involvement in the research process are fundamental to supporting movement of research programs toward greater patient engagement. We describe preliminary efforts to engage members of a community group of patients living with heart disease to better understand their interest and perspectives on involvement in research. A semi-structured focus group guide was developed to probe willingness to participate in the following three phases of research: preparation, execution, and translation. The focus group discussion, and our summary of key messages gleaned from said discussion, was organized around the phases of research that patients may be involved in, with the goal of delineating degrees of interest expressed for engagement in each phase. Consistent with what is known from the literature, a clear preference for engagement during the preparation and translation phase of the research process emerged. This preliminary conversation will guide our ongoing research efforts toward greater inclusion of patients throughout the research process.

Teamwork in perioperative nursing. Understanding team development, effectiveness, evaluation.

PubMed

Farley, M J

1991-03-01

Teams are an essential part of perioperative nursing practice. Nurses who have a knowledge of teamwork and experience in working on teams have a greater understanding of the processes and problems involved as teams develop from new, immature teams to those that are mature and effective. This understanding will assist nurses in helping their teams achieve a higher level of productivity, and members will be more satisfied with team efforts. Team development progresses through several stages. Each stage has certain characteristics and desired outcomes. At each stage, team members and leaders have certain responsibilities. Team growth does not take place automatically and inevitably, but as a consequence of conscious and unconscious efforts of its leader and members to solve problems and satisfy needs. Building and maintaining a team is certainly work, but work that brings a great deal of satisfaction and feelings of pride in accomplishment. According to I Tenzer, RN, MS, teamwork "is not a panacea; it is a viable approach to developing a hospital's most valuable resource--people."

Children's Play in Diverse Cultures. Children's Play in Society Series.

ERIC Educational Resources Information Center

Roopnarine, Jaipaul L., Ed.; And Others

This book illuminates play as a universal and culture-specific activity. It provides needed information about the behavior of children in diverse cultural contexts as well as about the play of children in unassimilated cultural or subcultural contexts. It offers readers the opportunity to develop greater sensitivity to and better understanding of…

Theorizing Content: Tools from Cultural History

ERIC Educational Resources Information Center

Hawkey, Kate

2007-01-01

What lies behind the lack of theorizing about content in history in contrast to much greater attention given to theorizing about children's developing understanding of historical skills and processes? Egan's model of the characteristic ways in which children of different ages engage with the world is used to raise the question of what content to…

Aboriginal Community Engagement in Primary Schooling: Promoting Learning through a Cross-Cultural Lens

ERIC Educational Resources Information Center

Turner, Angela; Wilson, Katie; Wilks, Judith L.

2017-01-01

This article reports on action research conducted at a primary school in rural New South Wales, Australia. The research responded to an expressed school aspiration to foster greater understanding of local Aboriginal culture, historical perspectives and knowledge systems within the school. An exploratory model was developed using a mixed methods…

Religiousness/Spirituality, Cardiovascular Disease, and Cancer: Cultural Integration for Health Research and Intervention

ERIC Educational Resources Information Center

Masters, Kevin S.; Hooker, Stephanie A.

2013-01-01

Objective: Recently, behavioral scientists have developed greater interest in understanding the relations between religiousness and spirituality (R/S) and health. Our objectives were to (a) provide an overview of the R/S and health literature specific to cardiovascular disease (CVD) and cancer, (b) discuss the importance of religious culture…

WordBytes: Exploring an Intermediate Constraint Format for Rapid Classification of Student Answers on Constructed Response Assessments

ERIC Educational Resources Information Center

Kim, Kerry J.; Meir, Eli; Pope, Denise S.; Wendel, Daniel

2017-01-01

Computerized classification of student answers offers the possibility of instant feedback and improved learning. Open response (OR) questions provide greater insight into student thinking and understanding than more constrained multiple choice (MC) questions, but development of automated classifiers is more difficult, often requiring training a…

Overcoming Misconceptions in Neurophysiology Learning: An Approach Using Color-Coded Animations

ERIC Educational Resources Information Center

Guy, Richard

2012-01-01

Anyone who has taught neurophysiology would be aware of recurring concepts that students find difficult to understand. However, a greater problem is the development of misconceptions that may be difficult to change. For example, one common misconception is that action potentials pass directly across chemical synapses. Difficulties may be…

Internationalisation as a Key Dimension to Teacher Education

ERIC Educational Resources Information Center

Dooly, Melinda; Villanueva, Maria

2006-01-01

The European Union has recognized the need for promoting social and political change through education. Special emphasis has been placed on the role of schools in personal and human development, along with the need for greater understanding of the diversity which makes up the European Union and throughout the world. This means that teachers are…

Developing Cultural Awareness in Foreign Language Teaching

ERIC Educational Resources Information Center

Shemshadsara, Zahra Ghorbani

2012-01-01

Culture awareness has become an important focus of modern language education, a shift that reflects a greater awareness of the inseparability of language and culture, and the need to prepare students for intercultural communication. The paper reports on an ongoing study into the presence and status of cultural understanding in EFL teaching. In…

Promoting Greater Understanding in Peers of Children Who Stammer

ERIC Educational Resources Information Center

Turnbull, Jackie

2006-01-01

Children who stammer are often negatively stereotyped by other children and by teachers. They can also be easily identified as targets for teasing and bullying by peers. This may adversely affect their interaction levels in school and lower their self-esteem. This article suggests an approach aimed at reducing the development of adverse attitudes…

Managing Cultural Assets from a Business Perspective.

ERIC Educational Resources Information Center

Price, Laura; Smith, Abby

Without understanding the value of collections as assets to the home institution, it is difficult for libraries to determine how best to make those assets most productive. This report describes how the Library of Congress developed and implemented a plan for greater accountability over its collections. The report presents a model for the…

Insertional mutagenesis in Populus: relevance and feasibility

Treesearch

Victor Busov; Matthias Fladung; Andrew Groover; Steven Strauss

2005-01-01

The recent sequencing of the first tree genome, that of the black cottonwood (Populus trichocarpa), opens a new chapter in tree functional genomics. While the completion of the genome is a milestone, mobilizing this significant resource for better understanding the growth and development of woody perennials will be an even greater undertaking in the...

Harnessing Openness to Improve Research, Teaching and Learning in Higher Education

ERIC Educational Resources Information Center

Committee for Economic Development, 2009

2009-01-01

This report examines higher education through the lens of openness. The goal is to understand the potential impact of greater openness on colleges and universities. Like other service industries such as finance or entertainment, higher education is rooted in information--its creation, analysis, and transmission--and the development of the skills…

Bullying Experiences among Children and Youth with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Cappadocia, M. Catherine; Weiss, Jonathan A.; Pepler, Debra

2012-01-01

Few studies have investigated bullying experiences among children diagnosed with autism spectrum disorders (ASD); however, preliminary research suggests that children with ASD are at greater risk for being bullied than typically developing peers. The aim of the current study was to build an understanding of bullying experiences among children with…

Heads, Shoulders, Knees and … Beaks?

ERIC Educational Resources Information Center

Barber, Ruth

2017-01-01

For many years teachers have been planning cross-curricular lessons to develop children's knowledge and understanding in two or more subjects at the same time, with the aim of showing children how to transfer skills from one subject to another and give greater purpose to their learning. However, following the revisions to the National Curriculum…

The Two Koreas. Foreign Policy Association Headline Series, No. 269.

ERIC Educational Resources Information Center

Cumings, Bruce

One in a series of booklets whose purpose is to stimulate greater and more effective understanding of world affairs among Americans, this seven-chapter report examines the political, economic, and anomalous positions of North and South Korea in the international system. "Traditional Legacies" traces the historical development of the two…

Factors Influencing Responsiveness to Feedback: On the Interplay between Fear, Confidence, and Reasoning Processes

ERIC Educational Resources Information Center

Eva, Kevin W.; Armson, Heather; Holmboe, Eric; Lockyer, Jocelyn; Loney, Elaine; Mann, Karen; Sargeant, Joan

2012-01-01

Self-appraisal has repeatedly been shown to be inadequate as a mechanism for performance improvement. This has placed greater emphasis on understanding the processes through which self-perception and external feedback interact to influence professional development. As feedback is inevitably interpreted through the lens of one's self-perceptions it…

Effect of Congenital Heart Defects on Language Development in Toddlers with Down Syndrome

ERIC Educational Resources Information Center

Visootsak, J.; Hess, B.; Bakeman, R.; Adamson, L. B.

2013-01-01

Background: Down syndrome (DS, OMIM #190685) is the most commonly identified genetic form of intellectual disability with congenital heart defect (CHD) occurring in 50% of cases. With advances in surgical techniques and an increasing lifespan, this has necessitated a greater understanding of the neurodevelopmental consequences of CHDs. Herein, we…

Canadian Studies for Elementary and Junior High School Teachers. A Syllabus and Resource Guide.

ERIC Educational Resources Information Center

State Univ., of New York, Plattsburgh. Coll. at Plattsburgh. Center for the Study of Canada.

Developed to promote greater awareness and understanding of Canada by American students and teachers, this interdisciplinary curriculum guide includes not only social studies, but also activities dealing with mathematics, science, environmental studies, English, art, and music. The book is divided into five modules, each giving a different…

Preparing School Administrators to Lead Technology Rich Professional Learning Communities in the Digital Age

ERIC Educational Resources Information Center

Branch, Mary Grace

2011-01-01

This study explores the coaching experiences of educational administrators in an attempt to gain greater understanding of how they develop the necessary skills to implement, lead, and support technology rich professional learning communities (PLCs). Participants came from a mix of urban, rural, and suburban school districts. Using semi-structured…

Resilient Parenting of Preschool Children at Developmental Risk

ERIC Educational Resources Information Center

Ellingsen, R.; Baker, B. L.; Blacher, J.; Crnic, K.

2014-01-01

Background: Given the great benefits of effective parenting to child development under normal circumstances, and the even greater benefits in the face of risk, it is important to understand why some parents manage to be effective in their interactions with their child despite facing formidable challenges. This study examined factors that promoted…

Louisiana waterthrush and benthic macroinvertebrate response to shale gas development

USGS Publications Warehouse

Wood, Petra; Frantz, Mack W.; Becker, Douglas A.

2016-01-01

Because shale gas development is occurring over large landscapes and consequently is affecting many headwater streams, an understanding of its effects on headwater-stream faunal communities is needed. We examined effects of shale gas development (well pads and associated infrastructure) on Louisiana waterthrush Parkesia motacilla and benthic macroinvertebrate communities in 12 West Virginia headwater streams in 2011. Streams were classed as impacted (n = 6) or unimpacted (n = 6) by shale gas development. We quantified waterthrush demography (nest success, clutch size, number of fledglings, territory density), a waterthrush Habitat Suitability Index, a Rapid Bioassessment Protocol habitat index, and benthic macroinvertebrate metrics including a genus-level stream-quality index for each stream. We compared each benthic metric between impacted and unimpacted streams with a Student's t-test that incorporated adjustments for normalizing data. Impacted streams had lower genus-level stream-quality index scores; lower overall and Ephemeroptera, Plecoptera, and Trichoptera richness; fewer intolerant taxa, more tolerant taxa, and greater density of 0–3-mm individuals (P ≤ 0.10). We then used Pearson correlation to relate waterthrush metrics to benthic metrics across the 12 streams. Territory density (no. of territories/km of stream) was greater on streams with higher genus-level stream-quality index scores; greater density of all taxa and Ephemeroptera, Plecoptera, and Trichoptera taxa; and greater biomass. Clutch size was greater on streams with higher genus-level stream-quality index scores. Nest survival analyses (n = 43 nests) completed with Program MARK suggested minimal influence of benthic metrics compared with nest stage and Habitat Suitability Index score. Although our study spanned only one season, our results suggest that shale gas development affected waterthrush and benthic communities in the headwater streams we studied. Thus, these ecological effects of shale gas development warrant closer examination.

Program logic: a framework for health program design and evaluation - the Pap nurse in general practice program.

PubMed

Hallinan, Christine M

2010-01-01

In this paper, program logic will be used to 'map out' the planning, development and evaluation of the general practice Pap nurse program in the Australian general practice arena. The incorporation of program logic into the evaluative process supports a greater appreciation of the theoretical assumptions and external influences that underpin general practice Pap nurse activity. The creation of a program logic model is a conscious strategy that results an explicit understanding of the challenges ahead, the resources available and time frames for outcomes. Program logic also enables a recognition that all players in the general practice arena need to be acknowledged by policy makers, bureaucrats and program designers when addressing through policy, issues relating to equity and accessibility of health initiatives. Logic modelling allows decision makers to consider the complexities of causal associations when developing health care proposals and programs. It enables the Pap nurse in general practice program to be represented diagrammatically by linking outcomes (short, medium and long term) with both the program activities and program assumptions. The research methodology used in the evaluation of the Pap nurse in general practice program includes a descriptive study design and the incorporation of program logic, with a retrospective analysis of Australian data from 2001 to 2009. For the purposes of gaining both empirical and contextual data for this paper, a data set analysis and literature review was performed. The application of program logic as an evaluative tool for analysis of the Pap PN incentive program facilitates a greater understanding of complex general practice activity triggers, and also allows this greater understanding to be incorporated into policy to facilitate Pap PN activity, increase general practice cervical smear and ultimately decrease burden of disease.

Women's bleeding patterns: ability to recall and predict menstrual events. World Health Organization Task Force on Psychosocial Research in Family, Planning, Special Programme of Research, Development and Research Training in Human Reproduction.

PubMed

1981-01-01

Objective records of the occurrence of menstrual bleeding were compared with women's subjective assessments of the timing and duration of these events. The number of days a woman experienced bleeding during each episode was relatively constant; however, the length of the bleeding episode varied greatly among the 13 cultures studies. A greater understanding of menstrual patterns is possible if the pattern is seen as a succession of discrete events rather than as a whole. A more careful use of terminology relating to these discrete events would provide greater understanding of menstruation for the woman concerned and those advising her. The methodology employed in the collection of data about menstrual events among illiterate women is described and suggestions given as to how such information can be most efficiently obtained.

A Methodology to Improving Unity of Effort for Mission Partner Planning

DTIC Science & Technology

2014-06-01

REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE A Methodology to Improving Unity of Effort for Mission Partner... language , or better yet, use a common lexicon (common definitions and terms for greater understanding). One fundamental step toward developing...to attempt to develop strong relationships while learning to speak each other’s language , or better yet, use a common lexicon (common definitions and

National Aeronautics Research, Development, Test and Evaluation (RDT&E) Infrastructure Plan

DTIC Science & Technology

2011-01-01

addressed in the National Aeronautics R&D Plan, identi- fying unnecessary redundancy solely on the basis of infrastructure required to support H H13 ...near, mid, and far terms, and impact not only scramjet propulsion systems, but potential turbine-based combined cycle systems as well. Turbine Engine...Icing Test Facilities A greater understanding of the impact that icing conditions have on turbine engine opera- tions is needed to develop enhanced

Uncaring Nurses: Mobilizing Power, Knowledge, Difference, and Resistance to Explain Workplace Violence in Academia.

PubMed

Berquist, Renee; St-Pierre, Isabelle; Holmes, Dave

2018-05-01

Violence among nurses and in nursing academia is a significant issue, with attention increasingly focused on damage resulting from psychological violence, such as bullying, harassment, aggression, and incivility. Each workplace's interpretation of violence will impact individual behavior within the organization. Organizational and environmental factors can contribute to violent behaviors becoming normalized in the workplace. When violent behaviors go unconstrained, they become imbedded within the workplace culture. An increased understanding of workplace culture is required to address workplace violence. The purpose of this article is to demonstrate how the use of this theoretical framework can provide greater understanding of the role of workplace culture in sustaining violent behaviors in nursing academia. The theoretical perspectives of Gail Mason on interpersonal violence and Michel Foucault on power were utilized to inform the research process and guide data analysis. The framework makes possible the exposure of a dominant discourse perpetuating violence in nursing academia. Power and violence were found to work together to shape knowledge and influence group norms and behaviors. The framework is useful in providing greater understanding of how the concepts of power, knowledge, difference, and resistance support the enactment of workplace violence. Investigating the influence of these concepts in the development of accepted practices and discourses may allow greater insight into ways violence and power are used to negotiate and enforce organizational rules and norms.

A Methodology to Determine the Psychomotor Performance of Helicopter Pilots During Flight Maneuvers.

PubMed

McMahon, Terry W; Newman, David G

2015-07-01

Helicopter flying is a complex psychomotor task requiring continuous control inputs to maintain stable flight and conduct maneuvers. Flight safety is impaired when this psychomotor performance is compromised. A comprehensive understanding of the psychomotor performance of helicopter pilots, under various operational and physiological conditions, remains to be developed. The purpose of this study was to develop a flight simulator-based technique for capturing psychomotor performance data of helicopter pilots. Three helicopter pilots conducted six low-level flight sequences in a helicopter simulator. Accelerometers applied to each flight control recorded the frequency and magnitude of movements. The mean (± SEM) number of control inputs per flight was 2450 (± 136). The mean (± SEM) number of control inputs per second was 1.96 (± 0.15). The mean (± SEM) force applied was 0.44 G (± 0.05 G). No significant differences were found between pilots in terms of flight completion times or number of movements per second. The number of control inputs made by the hands was significantly greater than the number of foot movements. The left hand control input forces were significantly greater than all other input forces. This study shows that the use of accelerometers in flight simulators is an effective technique for capturing accurate, reliable data on the psychomotor performance of helicopter pilots. This technique can be applied in future studies to a wider range of operational and physiological conditions and mission types in order to develop a greater awareness and understanding of the psychomotor performance demands on helicopter pilots.

Understanding chronic heart failure

PubMed Central

Fenton, Matthew; Burch, Michael

2007-01-01

The key principles of chronic heart failure and the development of clinical management strategies are described. The physiological changes in chronic heart failure and the clinical management of children with heart failure are considered, but the treatment of heart failure related to congenital heart disease or the intensive care management of heart failure are not mentioned as both topics require consideration in their own right. A greater understanding of the maladaptive responses to chronic heart failure has enabled targeted therapy to be introduced with consequent improvement in symptoms, reduction in hospitalisation and lower mortality. PMID:17715446

Linguistics, human communication and psychiatry.

PubMed

Thomas, P; Fraser, W

1994-11-01

Psycholinguistics and sociolinguistics have extended our understanding of the abnormal communication seen in psychosis, as well as that of people with autism and Asperger's syndrome. Psycholinguistics has the potential to increase the explanatory power of cognitive and neuropsychological approaches to psychosis and new methods of assessment and therapy are now being developed, based on linguistic theory. A MEDLINE literature search was used. Of 205 relevant articles identified, 65 were selected for review. Greater familiarity with linguistic theory could improve psychiatrists' assessment skills and their understanding of the relevance of human communication to the new cognitive models of psychosis.

Adolescent Ego-Development Trajectories and Young Adult Relationship Outcomes

PubMed Central

Hennighausen, Katherine H.; Hauser, Stuart T.; Billings, Rebecca L.; Schultz, Lynn Hickey; Allen, Joseph P.

2006-01-01

Adolescent ego-development trajectories were related to close-relationship outcomes in young adulthood. An adolescent sample completed annual measures of ego development from ages 14 through 17. The authors theoretically determined and empirically traced five ego-development trajectories reflecting stability or change. At age 25, the sample completed a close-relationship interview and consented for two peers to rate the participants’ego resiliency and hostility. Participants who followed the profound-arrest trajectory in adolescence reported more mundane sharing of experiences, more impulsive or egocentric conflict-resolution tactics, and less mature interpersonal understanding in their young adult relationships, and their young adult peers described these participants as more hostile. Participants who attained or maintained higher levels of ego development in adolescence reported more complex sharing of experiences, more collaborative conflict-resolution strategies, and greater interpersonal understanding, and their young adult peers rated them as less hostile and as more flexible. PMID:17404603

Everyday Leadership: Attitudes and Actions for Respect and Success. Guidebook for Teens

ERIC Educational Resources Information Center

MacGregor, Mariam G.

2006-01-01

Written and experiential activities help teens discover their own leadership potential and develop skills that guide them to act responsibly and make a difference in the world around them. Teens gain a greater understanding of who they are, what matters to them, how that translates into leadership, and how leadership relates to everyday life.…

Current Campus Issues. Proceedings June 1969 Institutes on College and University Administration.

ERIC Educational Resources Information Center

University Consultants, Inc., Cambridge, MA.

The Institutes were held in Washington, D.C. and Ann Arbor, Mich. in June 1969, and were directed toward helping administrators develop greater senstivity and understanding of the critical issues facing them. This monograph contains a description of the 3-day "campus confrontation crisis" game played by the conference participants, and presents…

I am from Delicious Lasagna: Exploring Cultural Identity with Digital Storytelling

ERIC Educational Resources Information Center

Fitts, Shanan; Gross, Lisa A.

2010-01-01

In an effort to gain greater insights into bilingual and bicultural children's understanding of their cultural and linguistic identities, the authors embarked on a Where I'm From (WIF) multi-media poetry project. The WIF project has great potential and value for developing students' language and communication skills, and for exploring the meaning…

Putting History in Its Place: Grounding the Australian Curriculum--History in Local Community

ERIC Educational Resources Information Center

Harrison, Neil

2012-01-01

This position paper develops the case for a greater focus on the teaching of local histories in the Australian Curriculum: History. It takes as its starting point an Indigenous epistemology that understands knowledge to be embedded in the land. This connection between knowledge and country is used to examine recent literature on whether the…

Integrated automation for continuous high-throughput synthetic chromosome assembly and transformation to identify improved yeast strains for industrial production of biofuels and bio-based chemicals

USDA-ARS?s Scientific Manuscript database

An exponential increase in our understanding of genomes, proteomes, and metabolomes provides greater impetus to address critical biotechnological issues such as sustainable production of biofuels and bio-based chemicals and, in particular, the development of improved microbial biocatalysts for use i...

Reframing Leadership as a Participative Pedagogy: The Working Theories of Early Years Professionals

ERIC Educational Resources Information Center

Murray, Janet; Clark, Rory McDowall

2013-01-01

Traditional notions of leadership are at odds with the pedagogy and ethos of Early Childhood Education and Care (ECEC), prompting increasing international concern to develop new understandings which are better suited and create greater leadership capacity. The introduction of the Early Years Professional (EYP) in England, as a leader of practice…

The Analysis of Cognitive Abilities in the Preschool Age.

ERIC Educational Resources Information Center

Blank, Marion

In order to gain a greater understanding of the intellectual strengths and weaknesses of the young child, a test was developed (for which data collection is ongoing) to investigate a broad range of cognitive skills in the three- to five-year age range. The test covers skills within four main spheres--cognitively Directed Perception, Concepts and…

La Participacion de los Padres en los Programas Preescolares. (Hispanic Parent Involvement in Early Childhood Programs.) ERIC Digest.

ERIC Educational Resources Information Center

Espinosa, Linda M.

To determine effective strategies for involving Hispanic parents in their children's early childhood programs, educators need to develop a greater understanding of the features of the Hispanic culture that influence parents' childrearing practices and orientation toward formal education. Educators should be aware of Hispanics' diversity in terms…

China on the Mekong: Legitimacy Imperatives and Policy Case Studies

DTIC Science & Technology

2013-12-01

1  B.  IMPORTANCE ................................................................................................1  C.  PROBLEMS...gross domestic product GMS Greater Mekong Subregion HDI human development indicators MRC Mekong River Commission MOU memoranda of understanding MPS...home affect China’s policies along the Mekong River? B. IMPORTANCE A careful investigation of PRC policies on the Mekong River will contribute to a

Integrated computational materials engineering: Tools, simulations and new applications

DOE PAGES

Madison, Jonathan D.

2016-03-30

Here, Integrated Computational Materials Engineering (ICME) is a relatively new methodology full of tremendous potential to revolutionize how science, engineering and manufacturing work together. ICME was motivated by the desire to derive greater understanding throughout each portion of the development life cycle of materials, while simultaneously reducing the time between discovery to implementation [1,2].

Motives and Tensions in the Release of Open Educational Resources: The UKOER Program

ERIC Educational Resources Information Center

Falconer, Isobel; Littlejohn, Allison; McGill, Lou; Beetham, Helen

2016-01-01

Open educational resources (OER) have been promoted as a path to universal education, supporting economic development and intercultural dialogue. However, to realise these benefits requires greater understanding of the factors that influence both OER supply and use. This paper examines an aspect of the supply side of the OER lifecycle--the motives…

The Influence of Work-Integrated Learning on Motivation to Undertake Graduate Studies

ERIC Educational Resources Information Center

Zegwaard, Karsten E.; McCurdy, Susan

2014-01-01

There has been concern around the lack of postgraduate qualified scientists and engineers (e.g., Gago et al., 2004; Koslow, 2005; Lovitts & Nelson, 2000). However, to be effective in increasing the number of science postgraduates, a greater understanding of why students go on to do graduate studies must be developed. Presented here is a study…

Development of DNA-based Identification methods to track the species composition of fish larvae within nearshore areas of the Great Lakes

EPA Science Inventory

The ability to track the identity and abundance of larval fish, which are ubiquitous during spawning season, may lead to a greater understanding of fish species distributions in Great Lakes nearshore areas including early-detection of invasive fish species before they become esta...

[East Syracuse-Minoa Schools Environmental Education Materials, Middle School Package, Grade 7--Science.

ERIC Educational Resources Information Center

East Syracuse - Minoa Central Schools, East Syracuse, NY.

These five environmental education science units are designed for use in the seventh grade. Skills such as note taking, organizing information, critical thinking, analysis of data, and scientific skills, and the correlation between skills and content area are emphasized throughout the units to develop in the student a greater understanding of his…

An Examination into the Learning Pattern Preferences of Students in Special Education

ERIC Educational Resources Information Center

Thone, Jaime L.

2013-01-01

As educational professionals strive to help students become efficient and effective learners, they must assist in the development of student learning strategies and a greater understanding of the learning process. The purpose of this study was to analyze and compare the learning pattern preferences of middle and high school students in general…

The Unexamined Student Is Not Worth Teaching: Preparation, the Zone of Proximal Development, and the Socratic Model of Scaffolded Learning

ERIC Educational Resources Information Center

Colter, Robert; Ulatowski, Joseph

2017-01-01

"Scaffolded learning" describes a cluster of instructional techniques designed to move students from a novice position toward greater understanding, such that they become independent learners. Our Socratic Model of Scaffolded Learning ("SMSL") includes two phases not normally included in discussions of scaffolded learning, the…

Psychological Growth, Cosmopolitanism, and Selection of Students for Cross-Cultural Educational Programs. Occasional Papers on Undergraduate Study Abroad.

ERIC Educational Resources Information Center

McEvoy, Theodore L.

It is suggested that greater attention be given to psychological development assessment in the selection of students for cross-cultural exchange programs. To date little effort has been made to evaluate such program objectives as: (1) fostering international understanding, and (2) attainment of educational experiences not available domestically.…

Handbook on Mexico for Elementary and Secondary Teachers.

ERIC Educational Resources Information Center

Gill, Clark C.; Mellenbruch, Julia K.

This guide presents a rationale for the study of a foreign culture, specifically the culture of Mexico, and develops ways of fitting this cultural education into the elementary and secondary education curriculum. It is felt that the study of any foreign culture leads to greater understanding of others and of oneself. Mexico is chosen because: (1)…

A Cross-Cultural Investigation into the Development of Place-Value Concepts of Children in Taiwan and the United States.

ERIC Educational Resources Information Center

Yang, Ma Tzu-Lin; Cobb, Paul

1995-01-01

Compares mathematics achievement of children in Taiwan and the United States by analyzing the arithmetical learning contexts of each. Interviews with parents and teachers identify cultural beliefs about learning arithmetic; interviews with students identify level of sophistication of arithmetical concepts. Found greater understanding by Chinese…

The Pedagogy of Ingenuity in Science: An Exploration of Creative Thinking in the Secondary Science Classroom

ERIC Educational Resources Information Center

Antink, Allison

2012-01-01

The importance of creative thinking in science cannot be overstated. Creativity is integral to the development of knowledge about the natural world and the knowledge, skills and abilities that support it are in need of greater understanding. The Next Generation Science Standards (2012) include practices that implicitly emphasize the creative…

The Impact of Community Involvement on the Success of Schoolyard Ecosystem Restoration/Education Programs: A Case Study Approach.

ERIC Educational Resources Information Center

Cline, Shannon; Cronin-Jones, Linda; Johnson, Courtney; Hakverdi, Meral; Penwell, Rebecca

Schoolyard ecosystem programs, such as mini-farms, gardens, or nature trails on school grounds, are usually designed to promote greater insight and understanding of ecological relationships and develop an appreciation of an individual's responsibility for environmental quality. This paper focuses on evaluation practices of schoolyard habitat…

"The family is the clinic, the community is the hospital": community mental health in Timor-Leste.

PubMed

Hawkins, Zoe; Tilman, Teofilo

2011-07-01

This paper describes the history and recent development of mental health services in Timor-Leste, a small developing country recovering from conflict. Challenges to effective service delivery are discussed as well as plans for future development. Timor-Leste's mental health service began just over a decade ago. Unlike many other low and middle income countries where hospital-based services predominate, the mental health model in Timor-Leste is entirely community based. However, challenges to effective mental health care delivery are similar to most developing countries and include a lack of sufficient financial resources, human resources, and mental health infrastructure. Addressing these issues successfully requires political will, a greater prioritization of mental health services, close coordination between stakeholders, as well as developments in the area of education, training and infrastructure. Greater understanding and education about the links between mental and physical health would benefit the overall health of the population, and integration of these respective policies may prove a successful method of more equitably redistributing finances and resources.

The Profile of Emotional Competence (PEC): development and validation of a self-reported measure that fits dimensions of emotional competence theory.

PubMed

Brasseur, Sophie; Grégoire, Jacques; Bourdu, Romain; Mikolajczak, Moïra

2013-01-01

Emotional Competence (EC), which refers to individual differences in the identification, understanding, expression, regulation and use of one's own emotions and those of others, has been found to be an important predictor of individuals' adaptation to their environment. Higher EC is associated with greater happiness, better mental and physical health, more satisfying social and marital relationships and greater occupational success. While it is well-known that EC (as a whole) predicts a number of important outcomes, it is unclear so far which specific competency(ies) participate(s) in a given outcome. This is because no measure of EC distinctly measures each of the five core emotional competences, separately for one's own and others' emotions. This lack of information is problematic both theoretically (we do not understand the processes at stake) and practically (we cannot develop customized interventions). This paper aims to address this issue. We developed and validated in four steps a complete (albeit short: 50 items) self-reported measure of EC: the Profile of Emotional Competence. Analyses performed on a representative sample of 5676 subjects revealed promising psychometric properties. The internal consistency of scales and subscales alike was satisfying, factorial structure was as expected, and concurrent/discriminant validity was good.

Considering sex and gender in Alzheimer disease and other dementias.

PubMed

Podcasy, Jessica L; Epperson, C Neill

2016-12-01

Suffering related to dementia is multifaceted because cognitive and physical functioning slowly deteriorates. Advanced age and sex, two of the most prominent risk factors for dementia, are not modifiable. Lifestyle factors such as smoking, excessive alcohol use, and poor diet modulate susceptibility to dementia in both males and females. The degree to which the resulting health conditions (eg, obesity, type 2 diabetes, and cardiovascular disease) impact dementia risk varies by sex. Depending on the subtype of dementia, the ratio of male to female prevalence differs. For example, females are at greater risk of developing Alzheimer disease dementia, whereas males are at greater risk of developing vascular dementia. This review examines sex and gender differences in the development of dementia with the goal of highlighting factors that require further investigation. Considering sex as a biological variable in dementia research promises to advance our understanding of the pathophysiology and treatment of these conditions.

Bilingualism Alters Children's Frontal Lobe Functioning for Attentional Control

PubMed Central

Arredondo, Maria M.; Hu, Xiao-Su; Satterfield, Teresa; Kovelman, Ioulia

2017-01-01

Bilingualism is a typical linguistic experience, yet relatively little is known about its impact on children's cognitive and brain development. Theories of bilingualism suggest early dual-language acquisition can improve children's cognitive abilities, specifically those relying on frontal lobe functioning. While behavioral findings present much conflicting evidence, little is known about its effects on children's frontal lobe development. Using functional Near-Infrared Spectroscopy (fNIRS), the findings suggest that Spanish-English bilingual children (n=13, ages 7-13) had greater activation in left prefrontal cortex during a non-verbal attentional control task relative to age-matched English monolinguals. In contrast, monolinguals (n=14) showed greater right prefrontal activation than bilinguals. The present findings suggest early bilingualism yields significant changes to the functional organization of children's prefrontal cortex for attentional control and carry implications for understanding how early life experiences impact cognition and brain development. PMID:26743118

Considering sex and gender in Alzheimer disease and other dementias

PubMed Central

Podcasy, Jessica L.; Epperson, C. Neill

2016-01-01

Suffering related to dementia is multifaceted because cognitive and physical functioning slowly deteriorates. Advanced age and sex, two of the most prominent risk factors for dementia, are not modifiable. Lifestyle factors such as smoking, excessive alcohol use, and poor diet modulate susceptibility to dementia in both males and females. The degree to which the resulting health conditions (eg, obesity, type 2 diabetes, and cardiovascular disease) impact dementia risk varies by sex. Depending on the subtype of dementia, the ratio of male to female prevalence differs. For example, females are at greater risk of developing Alzheimer disease dementia, whereas males are at greater risk of developing vascular dementia. This review examines sex and gender differences in the development of dementia with the goal of highlighting factors that require further investigation. Considering sex as a biological variable in dementia research promises to advance our understanding of the pathophysiology and treatment of these conditions. PMID:28179815

Decoding molecular interactions in microbial communities

PubMed Central

Abreu, Nicole A.; Taga, Michiko E.

2016-01-01

Microbial communities govern numerous fundamental processes on earth. Discovering and tracking molecular interactions among microbes is critical for understanding how single species and complex communities impact their associated host or natural environment. While recent technological developments in DNA sequencing and functional imaging have led to new and deeper levels of understanding, we are limited now by our inability to predict and interpret the intricate relationships and interspecies dependencies within these communities. In this review, we highlight the multifaceted approaches investigators have taken within their areas of research to decode interspecies molecular interactions that occur between microbes. Understanding these principles can give us greater insight into ecological interactions in natural environments and within synthetic consortia. PMID:27417261

The typology and development of attitude to primary science education

NASA Astrophysics Data System (ADS)

Gray, Adelaide

The introduction and development of science within the primary curriculum has been a challenge to teachers, parents and children and a highly politicised decision. Augmenting any difficulties are the images of science within popular culture and the traditions of scientific inquiry that have maintained the Western, male elitist hierarchy of the Vienna circle throughout the last millennium. The Royal Society's committee on the public understanding of science has recognised the difficulty in recruiting students to higher-level science study and embarked on a programme of sponsorship to address this. At the same time major governmental policy changes have provided a new 'market' model of education that has encouraged parental involvement in schools and enforced a new 'transparency' of evaluation on schools through league tables and Ofsted. Set against this backdrop, this research explores the development of attitudes to science and science education in the parent's of primary school aged children. It examines the perceptions of science and science education through the narrative of the parent's and their understanding of the interaction between different areas of science. The use of key events within narrative as a method of exploring attitude and conceptual development is novel to this research and through this exploration the concept of attitude itself is examined and criticised developing a new concept of attitude as process-based rather than static or crystallised. This reconceptualisation allows a more operational understanding of attitude that overcomes the difficulties of the traditional concept, which has only a limited theoretical basis on which to examine behaviour. The research generates a typology for views of science and the more operational compliment to this, stance to science. This framework allows a greater understanding of attitude formation, how science is perceived and how this perception is actualised. It is particularly interesting given the current interest in increasing parental involvement in the education of their children, as this may lead to a greater impact of parental attitude on children. This study argues that the affective component of attitude is of paramount important in the developing science experiences children and the narrative nature of knowledge transmission can illuminate how parents relate to their children's experiences at school.

Something has shifted: Nursing students' global perspective following international clinical placements.

PubMed

Gower, Shelley; Duggan, Ravani; Dantas, Jaya A R; Boldy, Duncan

2017-10-01

To examine understandings of global health issues among nursing students following participation in an international clinical placement during their pre-registration university education. Universities use international clinical placements, especially in developing countries, to develop cultural awareness in students; however, little is known about the longer term influences on students' understandings of global nursing. A retrospective cross-sectional design was used, using an exploratory, descriptive qualitative approach. Individual semi-structured interviews were conducted in 2014 with a purposive sample of 25 pre-registration nursing students from four Western Australian universities who undertook clinical placements across five countries. Data were analysed using inductive thematic analysis. Findings highlight that students developed new understandings around health systems including fragility of resource access, differences in clinical practice and variances in nursing roles between settings. Students also experienced challenges but were able to appreciate alternative world viewpoints. International clinical placements can develop greater awareness and help students form realistic strategies for using their nursing skills globally. Pre-placement training in cultural awareness and health system realities, along with strong supervisory support, is critical to success. © 2017 John Wiley & Sons Ltd.

FY2012 Advanced Power Electronics and Electric Motors Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, Susan A.

The Advanced Power Electronics and Electric Motors (APEEM) program within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE), electric motor (EM), thermal management, and traction drive system technologies that will leapfrog current on-the-road technologies. The research and development is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow's automobiles will function as a unified system to improve fuel efficiency.

FY2010 Annual Progress Report for Advanced Power Electronics and Electric Motors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, Susan A.

2011-01-01

The Advanced Power Electronics and Electric Machines (APEEM) subprogram within the Vehicle Technologies Program provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE) and electric motor technologies that will leapfrog current on-the-road technologies. The research and development (R&D) is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow’s automobiles will function as a unified system to improve fuel efficiency.

[Breastfeeding, gross motor development and obesity, is there any causal association?

PubMed

Weisstaub N, Gerardo; Schonhaut B, Luisa; Salazar R, Gabriela

2017-01-01

Childhood obesity is the main nutritional and public health problem in Chile, being the principal causes, the increase in energy dense foods and the decline of physical activity. Interventions to prevent obesity at infancy are focused mainly in improving quality and quantity of dietary intake, without taking into account physical activity, which is expressed under two years of age, mainly by motor development. Some studies have proven that motor development at early age, may influence the ability to perform physical activity. Thus, infants scoring a lower motor development may have a greater risk of becoming obese. It isn’t know if childhood obesity causes lower motor development (given that children may have greater difficulty to move), or on the contrary, it is the lower ability to move, which increases the obesity risk. The objective of this manuscriptis analize the evidence regards the relation between breastfeeding, motor development and obesity in the childhood.To be able to understand this asocation and casual mecanism, it is important to develop stategys focused in early infancy to promote breastfeeding, healthy eating and early stimulation, starting in pediatric office.

Digital Media and Risks for Adolescent Substance Abuse and Problematic Gambling.

PubMed

Romer, Dan; Moreno, Megan

2017-11-01

Digital media provide increased opportunities for both marketing and social transmission of risky products and behavior. We briefly review what is known about adolescent exposure to favorable presentations of addictive substances, such as alcohol, tobacco, and marijuana, as well as behaviors such as gambling, on social and other online media. Our understanding of these influences and whether they require greater regulation is still developing, and recommendations for future research to address these gaps in our understanding are described. Potential strategies to intervene in these environments to protect adolescents and young adults from the adverse effects of these products are described, as well as future challenges for developing interventions. Copyright © 2017 by the American Academy of Pediatrics.

Games as Tools to Address Conservation Conflicts.

PubMed

Redpath, Steve M; Keane, Aidan; Andrén, Henrik; Baynham-Herd, Zachary; Bunnefeld, Nils; Duthie, A Bradley; Frank, Jens; Garcia, Claude A; Månsson, Johan; Nilsson, Lovisa; Pollard, Chris R J; Rakotonarivo, O Sarobidy; Salk, Carl F; Travers, Henry

2018-06-01

Conservation conflicts represent complex multilayered problems that are challenging to study. We explore the utility of theoretical, experimental, and constructivist approaches to games to help to understand and manage these challenges. We show how these approaches can help to develop theory, understand patterns in conflict, and highlight potentially effective management solutions. The choice of approach should be guided by the research question and by whether the focus is on testing hypotheses, predicting behaviour, or engaging stakeholders. Games provide an exciting opportunity to help to unravel the complexity in conflicts, while researchers need an awareness of the limitations and ethical constraints involved. Given the opportunities, this field will benefit from greater investment and development. Copyright © 2018 Elsevier Ltd. All rights reserved.

The Cost of Disengagement: Examining the Real Story of Absenteeism in Two Michigan Counties

ERIC Educational Resources Information Center

Rencher, Charles L.

2016-01-01

This Capstone project intended to create a greater awareness and develop an understanding of the impact of attendance on academic performance. Schools are faced with the tasks of ensuring students attend school and keeping them engaged while they are at school. This project encourages the reader to look past school attendance as a mere student…

Examining Power Struggles as a Signifier of Successful Partnership Working: A Case Study of Partnership Dynamics

ERIC Educational Resources Information Center

Derkzen, Petra; Franklin, Alex; Bock, Bettina

2008-01-01

In Britain, and Wales particularly, inclusion and equal opportunities for all became key principles guiding the work of the many partnerships that were established at the beginning of this century. A primary objective of this paper is to develop a greater understanding of the politics and processes within "partnership" as a widely used…

Using Paper Folding, Fraction Walls, and Number Lines to Develop Understanding of Fractions for Students from Years 5-8

ERIC Educational Resources Information Center

Pearn, Catherine Ann

2007-01-01

Several researchers have noted how children's whole number schemes can interfere with their efforts to learn fractions. An Australian study found that children who were successful with the solution of rational number tasks exhibited greater whole number knowledge and more flexible solution strategies. Behr and Post (1988) indicated that children…

A Bibliometric Study of Scholarly Articles Published by Library and Information Science Authors about Open Access

ERIC Educational Resources Information Center

Grandbois, Jennifer; Beheshti, Jamshid

2014-01-01

Introduction: This study aims to gain a greater understanding of the development of open access practices amongst library and information science authors, since their role is integral to the success of the broader open access movement. Method: Data were collected from scholarly articles about open access by library and information science authors…

Toward a Greater Understanding: Utilizing Book Discussions to Effectively Engage Students in the Exploration of Women and Leadership Issues

ERIC Educational Resources Information Center

Scott, Heather Inez Ricks

2016-01-01

This article examines the use of a book discussion as an instructional tool for developing leadership competency skills in female university students. A book discussion centered on Sheryl Sandberg's book "Lean In" was held as a means to conceptualize discourse regarding leadership issues in the arena of women and leadership in a…

Understanding "Together and Apart": A Case Study of Edward's Explorations at Nursery

ERIC Educational Resources Information Center

Arnold, Cath

2009-01-01

Edward was one of 58 children studied by workers and parents as part of a study on Well-being and Resilience at the Pen Green Nursery. Within the larger study, eight children were studied in greater depth in order to explore connections between cognitive and emotional development. Schematic theory and attachment theory were used as frameworks for…

Science and Math Activities and Resources for Teaching Home Economics (S.M.A.R.T.).

ERIC Educational Resources Information Center

Levine, Marjorie C.

This guide was written to aid home economics teachers in developing a greater understanding and use of basic skills in the home economics curriculum. The objectives of this guide are (1) to expand the awareness of underlying mathematics and science principles in the consumer and vocational home economics curriculum and (2) to provide a bank of…

Quantifying restoration effectiveness using multi-scale habitat models: Implications for sage-grouse in the Great Basin

Treesearch

Robert S. Arkle; David S. Pilliod; Steven E. Hanser; Matthew L. Brooks; Jeanne C. Chambers; James B. Grace; Kevin C. Knutson; David A. Pyke; Justin L. Welty; Troy A. Wirth

2014-01-01

A recurrent challenge in the conservation of wide-ranging, imperiled species is understanding which habitats to protect and whether we are capable of restoring degraded landscapes. For Greater Sage-grouse (Centrocercus urophasianus), a species of conservation concern in the western United States, we approached this problem by developing multi-scale empirical models of...

A cross-syndrome evaluation of a new attention rating scale: The Scale of Attention in Intellectual Disability.

PubMed

Freeman, Nerelie C; Gray, Kylie M; Taffe, John R; Cornish, Kim M

2016-10-01

Whilst neuropsychological research has enhanced our understanding of inattentive and hyperactive behaviours among children with intellectual disability (ID), the absence of rating scales developed for this group continues to be a gap in knowledge. This study examined these behaviours in 176 children with autism spectrum disorder (ASD), Down Syndrome (DS), or idiopathic ID using a newly developed teacher rating scale, the Scale of Attention in Intellectual Disability. Findings suggested that children with ASD had a significantly greater breadth of hyperactive/impulsive behaviours than those with DS or idiopathic ID. These findings support existing research suggesting differing profiles of attention and activity across groups. Understanding disorder-specific profiles has implications for developing strategies to support students with ID in the classroom. Copyright © 2016 Elsevier Ltd. All rights reserved.

Are histological alterations observed in the gallbladder precancerous lesions?

PubMed Central

Meirelles-Costa, Adriana Lúcia Agnelli; Bresciani, Claudio José Caldas; Perez, Rodrigo Oliva; Bresciani, Barbara Helou; Siqueira, Sheila Aparecida C.; Cecconello, Ivan

2010-01-01

INTRODUCTION Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required. PMID:20186297

Carbohydrates, pollinators, and cycads

PubMed Central

Marler, Thomas E; Lindström, Anders J

2015-01-01

Cycad biology, ecology, and horticulture decisions are not supported by adequate research, and experiments in cycad physiology in particular have been deficient. Our recent report on free sugar content in a range of cycad taxa and tissues sets the stage for developing continued carbohydrate research. Growth and development of cycad pollen, mediation of the herbivory traits of specialist pollinators, and support of expensive strobilus behavioral traits are areas of cycad pollination biology that would benefit from a greater understanding of the role of carbohydrate relations. PMID:26479502

Cost accounting helps ensure group practice profitability.

PubMed

Conrad, K A; Nagle, C B; Wunar, R J

1996-11-01

Physician practice managers are faced with the challenge of developing overall practice budgets, identifying strategies for the practice, and negotiating profitable managed care contracts. To accomplish these objectives, they need to understand and manage the costs associated with practice operations. Practices that have used cost accounting methodologies to identify their operational costs in greater detail and have developed methods to effectively manage their costs are likely to be more attractive partners to health plans and better positioned to thrive under managed care.

Socioscientific Issues: A Path Towards Advanced Scientific Literacy and Improved Conceptual Understanding of Socially Controversial Scientific Theories

NASA Astrophysics Data System (ADS)

Pinzino, Dean William

This thesis investigates the use of socioscientific issues (SSI) in the high school science classroom as an introduction to argumentation and socioscientific reasoning, with the goal of improving students' scientific literacy (SL). Current research is reviewed that supports the likelihood of students developing a greater conceptual understanding of scientific theories as well as a deeper understanding of the nature of science (NOS), through participation in informal and formal forms of argumentation in the context of SSI. Significant gains in such understanding may improve a student's ability to recognize the rigor, legitimacy, and veracity of scientific claims and better discern science from pseudoscience. Furthermore, students that participate in significant SSI instruction by negotiating a range of science-related social issues can make significant gains in content knowledge and develop the life-long skills of argumentation and evidence-based reasoning, goals not possible in traditional lecture-based science instruction. SSI-based instruction may therefore help students become responsible citizens. This synthesis also suggests that that the improvements in science literacy and NOS understanding that develop from sustained engagement in SSI-based instruction will better prepare students to examine and scrutinize socially controversial scientific theories (i.e., evolution, global warming, and the Big Bang).

Predicting Greater Prairie-Chicken Lek Site Suitability to Inform Conservation Actions

PubMed Central

Hovick, Torre J.; Dahlgren, David K.; Papeş, Monica; Elmore, R. Dwayne; Pitman, James C.

2015-01-01

The demands of a growing human population dictates that expansion of energy infrastructure, roads, and other development frequently takes place in native rangelands. Particularly, transmission lines and roads commonly divide rural landscapes and increase fragmentation. This has direct and indirect consequences on native wildlife that can be mitigated through thoughtful planning and proactive approaches to identifying areas of high conservation priority. We used nine years (2003–2011) of Greater Prairie-Chicken (Tympanuchus cupido) lek locations totaling 870 unique leks sites in Kansas and seven geographic information system (GIS) layers describing land cover, topography, and anthropogenic structures to model habitat suitability across the state. The models obtained had low omission rates (<0.18) and high area under the curve scores (AUC >0.81), indicating high model performance and reliability of predicted habitat suitability for Greater Prairie-Chickens. We found that elevation was the most influential in predicting lek locations, contributing three times more predictive power than any other variable. However, models were improved by the addition of land cover and anthropogenic features (transmission lines, roads, and oil and gas structures). Overall, our analysis provides a hierarchal understanding of Greater Prairie-Chicken habitat suitability that is broadly based on geomorphological features followed by land cover suitability. We found that when land features and vegetation cover are suitable for Greater Prairie-Chickens, fragmentation by anthropogenic sources such as roadways and transmission lines are a concern. Therefore, it is our recommendation that future human development in Kansas avoid areas that our models identified as highly suitable for Greater Prairie-Chickens and focus development on land cover types that are of lower conservation concern. PMID:26317349

Predicting Greater Prairie-Chicken Lek Site Suitability to Inform Conservation Actions.

PubMed

Hovick, Torre J; Dahlgren, David K; Papeş, Monica; Elmore, R Dwayne; Pitman, James C

2015-01-01

The demands of a growing human population dictates that expansion of energy infrastructure, roads, and other development frequently takes place in native rangelands. Particularly, transmission lines and roads commonly divide rural landscapes and increase fragmentation. This has direct and indirect consequences on native wildlife that can be mitigated through thoughtful planning and proactive approaches to identifying areas of high conservation priority. We used nine years (2003-2011) of Greater Prairie-Chicken (Tympanuchus cupido) lek locations totaling 870 unique leks sites in Kansas and seven geographic information system (GIS) layers describing land cover, topography, and anthropogenic structures to model habitat suitability across the state. The models obtained had low omission rates (<0.18) and high area under the curve scores (AUC >0.81), indicating high model performance and reliability of predicted habitat suitability for Greater Prairie-Chickens. We found that elevation was the most influential in predicting lek locations, contributing three times more predictive power than any other variable. However, models were improved by the addition of land cover and anthropogenic features (transmission lines, roads, and oil and gas structures). Overall, our analysis provides a hierarchal understanding of Greater Prairie-Chicken habitat suitability that is broadly based on geomorphological features followed by land cover suitability. We found that when land features and vegetation cover are suitable for Greater Prairie-Chickens, fragmentation by anthropogenic sources such as roadways and transmission lines are a concern. Therefore, it is our recommendation that future human development in Kansas avoid areas that our models identified as highly suitable for Greater Prairie-Chickens and focus development on land cover types that are of lower conservation concern.

Vegetation Demographics in Earth System Models: a review of progress and priorities

DOE PAGES

Fisher, Rosie A.; Koven, Charles D.; Anderegg, William R. L.; ...

2017-09-18

Numerous current efforts seek to improve the representation of ecosystem ecology and vegetation demographic processes within Earth System Models (ESMs). Furthermore, these developments are widely viewed as an important step in developing greater realism in predictions of future ecosystem states and fluxes. Increased realism, however, leads to increased model complexity, with new features raising a suite of ecological questions that require empirical constraints. We review the developments that permit the representation of plant demographics in ESMs, and identify issues raised by these developments that highlight important gaps in ecological understanding. These issues inevitably translate into uncertainty in model projections butmore » also allow models to be applied to new processes and questions concerning the dynamics of real-world ecosystems. We also argue that stronger and more innovative connections to data, across the range of scales considered, are required to address these gaps in understanding. The development of first-generation land surface models as a unifying framework for ecophysiological understanding stimulated much research into plant physiological traits and gas exchange. Constraining predictions at ecologically relevant spatial and temporal scales will require a similar investment of effort and intensified inter-disciplinary communication.« less

Vegetation Demographics in Earth System Models: a review of progress and priorities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisher, Rosie A.; Koven, Charles D.; Anderegg, William R. L.

Numerous current efforts seek to improve the representation of ecosystem ecology and vegetation demographic processes within Earth System Models (ESMs). Furthermore, these developments are widely viewed as an important step in developing greater realism in predictions of future ecosystem states and fluxes. Increased realism, however, leads to increased model complexity, with new features raising a suite of ecological questions that require empirical constraints. We review the developments that permit the representation of plant demographics in ESMs, and identify issues raised by these developments that highlight important gaps in ecological understanding. These issues inevitably translate into uncertainty in model projections butmore » also allow models to be applied to new processes and questions concerning the dynamics of real-world ecosystems. We also argue that stronger and more innovative connections to data, across the range of scales considered, are required to address these gaps in understanding. The development of first-generation land surface models as a unifying framework for ecophysiological understanding stimulated much research into plant physiological traits and gas exchange. Constraining predictions at ecologically relevant spatial and temporal scales will require a similar investment of effort and intensified inter-disciplinary communication.« less

Knowledge of Dementia: Do family members understand dementia as a terminal condition?

PubMed

Andrews, Sharon; McInerney, Fran; Toye, Christine; Parkinson, Camillus-Anthony; Robinson, Andrew

2017-07-01

Current research identifies advanced dementia to be the terminal phase of this progressive and incurable condition. However, there has been relatively little investigation into how family members of people with advanced dementia understand their relative's condition. In this article, we report on semi-structured interviews with 10 family members of people with advanced dementia, in a residential aged care facility. Using a qualitative, descriptive design, we explored family members' understandings of dementia, whether they were aware that it was a terminal condition, and the ways they developed their understandings. Findings revealed that the majority of family members could not recognize the terminal nature of dementia. Relying on predominantly lay understandings, they had little access to formal information and most failed to conceptualize a connection between dementia and death. Moreover, family members engaged in limited dialogue with aged care staff about such issues, despite their relatives being in an advanced stage of the disease. Findings from our study suggest that how family members understand their relative's condition requires greater attention. The development of staff/family partnerships that promote shared communication about dementia and dying may enhance family members' understandings of the dementia trajectory and the types of decisions they may be faced with during the more advanced stages of the disease.

Associations between extreme precipitation and acute gastro-intestinal illness due to cryptosporidiosis and giardiasis in an urban Canadian drinking water system (1997-2009).

PubMed

Chhetri, Bimal K; Takaro, Tim K; Balshaw, Robert; Otterstatter, Michael; Mak, Sunny; Lem, Marcus; Zubel, Marc; Lysyshyn, Mark; Clarkson, Len; Edwards, Joanne; Fleury, Manon D; Henderson, Sarah B; Galanis, Eleni

2017-10-01

Drinking water related infections are expected to increase in the future due to climate change. Understanding the current links between these infections and environmental factors is vital to understand and reduce the future burden of illness. We investigated the relationship between weekly reported cryptosporidiosis and giardiasis (n = 7,422), extreme precipitation (>90th percentile), drinking water turbidity, and preceding dry periods in a drinking water system located in greater Vancouver, British Columbia, Canada (1997-2009) using distributed lag non-linear Poisson regression models adjusted for seasonality, secular trend, and the effect of holidays on reporting. We found a significant increase in cryptosporidiosis and giardiasis 4-6 weeks after extreme precipitation. The effect was greater following a dry period. Similarly, extreme precipitation led to significantly increased turbidity only after prolonged dry periods. Our results suggest that the risk of cryptosporidiosis and giardiasis increases with extreme precipitation, and that the effects are more pronounced after a prolonged dry period. Given that extreme precipitation events are expected to increase with climate change, it is important to further understand the risks from these events, develop planning tools, and build resilience to these future risks.

Sharing methodology: a worked example of theoretical integration with qualitative data to clarify practical understanding of learning and generate new theoretical development.

PubMed

Yardley, Sarah; Brosnan, Caragh; Richardson, Jane

2013-01-01

Theoretical integration is a necessary element of study design if clarification of experiential learning is to be achieved. There are few published examples demonstrating how this can be achieved. This methodological article provides a worked example of research methodology that achieved clarification of authentic early experiences (AEEs) through a bi-directional approach to theory and data. Bi-directional refers to our simultaneous use of theory to guide and interrogate empirical data and the use of empirical data to refine theory. We explain the five steps of our methodological approach: (1) understanding the context; (2) critique on existing applications of socio-cultural models to inform study design; (3) data generation; (4) analysis and interpretation and (5) theoretical development through a novel application of Metis. These steps resulted in understanding of how and why different outcomes arose from students participating in AEE. Our approach offers a mechanism for clarification without which evidence-based effective ways to maximise constructive learning cannot be developed. In our example it also contributed to greater theoretical understanding of the influence of social interactions. By sharing this example of research undertaken to develop both theory and educational practice we hope to assist others seeking to conduct similar research.

The relevance of Hegel's Phenomenology of Spirit to the process of contemporary psychoanalysis.

PubMed

Chessick, Richard D

2008-01-01

Do changes in psychoanalytic technique represent progress in knowledge or are they for the most part a sideways movement in tune with the particular changes in the socioeconomic milieu of the day? Hegel raised the question in the area of philosophy when discussing the stages in the development of self-consciousness. For him this was an inevitable development toward a greater and greater self-understanding, going through various phases until Absolute Spirit (Mind) became completely cognizant of itself. This metaphysical conception was the cornerstone of Hegel's thought as first presented in his chaotic masterpiece, Phenomenology of Spirit. In this article I will examine his philosophical vision as expressed in that masterpiece, compare it with that of Freud, and discuss aspects of it that are pertinent to the practice of contemporary psychoanalysis.

Functional traits in agriculture: agrobiodiversity and ecosystem services.

PubMed

Wood, Stephen A; Karp, Daniel S; DeClerck, Fabrice; Kremen, Claire; Naeem, Shahid; Palm, Cheryl A

2015-09-01

Functional trait research has led to greater understanding of the impacts of biodiversity in ecosystems. Yet, functional trait approaches have not been widely applied to agroecosystems and understanding of the importance of agrobiodiversity remains limited to a few ecosystem processes and services. To improve this understanding, we argue here for a functional trait approach to agroecology that adopts recent advances in trait research for multitrophic and spatially heterogeneous ecosystems. We suggest that trait values should be measured across environmental conditions and agricultural management regimes to predict how ecosystem services vary with farm practices and environment. This knowledge should be used to develop management strategies that can be easily implemented by farmers to manage agriculture to provide multiple ecosystem services. Copyright © 2015 Elsevier Ltd. All rights reserved.

One Smithsonian: Greater Reach, Greater Relevance, Profound Impact. Annual Performance Plan, Fiscal Year 2018

ERIC Educational Resources Information Center

Smithsonian Institution, 2018

2018-01-01

In December 2017, the Smithsonian unveiled a new Strategic Plan. It expands on the "Grand Challenges"--Unlocking the Mysteries of the Universe, Understanding and Sustaining a Biodiverse Planet, Valuing World Cultures, Understanding the American Experience, and Magnifying the Transformative Power of Arts and Design--by setting goals to…

Developing Essential Understanding of Addition and Subtraction for Teaching Mathematics in Pre-K-Grade 2

ERIC Educational Resources Information Center

Karp, Karen; Caldwell, Janet; Zbiek, Rose Mary; Bay-Williams, Jennifer

2011-01-01

What is the relationship between addition and subtraction? How do individuals know whether an algorithm will always work? Can they explain why order matters in subtraction but not in addition, or why it is false to assert that the sum of any two whole numbers is greater than either number? It is organized around two big ideas and supported by…

Research on spacecraft electrical power conversion

NASA Technical Reports Server (NTRS)

Wilson, T. G.

1983-01-01

The history of spacecraft electrical power conversion in literature, research and practice is reviewed. It is noted that the design techniques, analyses and understanding which were developed make today's contribution to power computers and communication installations. New applications which require more power, improved dynamic response, greater reliability, and lower cost are outlined. The switching mode approach in electronic power conditioning is discussed. Technical aspects of the research are summarized.

Treatment of Children with Mental Illness: Frequently Asked Questions about the Treatment of Mental Illness in Children

ERIC Educational Resources Information Center

National Institute of Mental Health (NIMH), 2009

2009-01-01

Research shows that half of all lifetime cases of mental illness begin by age 14. Scientists are discovering that changes in the body leading to mental illness may start much earlier, before any symptoms appear. Through greater understanding of when and how fast specific areas of children's brains develop, we are learning more about the early…

Using GIS (Geographic Information Systems) to Analyze Public School Bullying: A Statewide Survey of 587,128 Students

ERIC Educational Resources Information Center

Stonier, Francis; Teed, Kenneth; Westine, Carl

2017-01-01

The use of surveys and GIS mapping allows one to more readily examine spatial relationships that may occur. Greater attention may be paid to understanding these clusters and develop better individualized interventions. The purpose of this study was to evaluate the bullying in a population of nearly 600,000 students who represent a population of…

Making Me Fire Safe. Second Grade. Fire Safety for Texans: Fire and Burn Prevention Curriculum Guide.

ERIC Educational Resources Information Center

Texas State Commission on Fire Protection, Austin.

This booklet comprises the second grade component of a series of curriculum guides on fire and burn prevention. Designed to meet the age-specific needs of second grade students, its objectives include acquiring basic understanding of how to prevent and put out fires and developing greater self-direction to prevent and react to fire, smoke, or burn…

United States Army Weapon Systems 2010

DTIC Science & Technology

2009-09-18

cue Soldiers based on how their brains process what they see, hear, and feel. Such neuro- ergonomic designs can exploit how the brain functions...environments, as well as techniques to use them for neuro- ergonomic design . Technology development will focus on solutions to cognition, visual...are accomplishing our mission. It is designed to promote greater understanding of our major acquisition programs. It describes what each is designed

An Examination of the Impact of an Assistive Technology Device on the Quality of Adult/Young Child Interactions

ERIC Educational Resources Information Center

Plunkett, Diane M.

2013-01-01

The purpose of this study was to gain greater understanding of the potential benefits of assistive technology (AT) devices on young children's social development. Specifically, changes to the quality of the adult/young child social interactions as a function of the child's access to and use of his/her personal AT device was examined. Using a…

Development of Intensive Motivational Interviewing (IMI) and Modifications for Treating Women with Alcohol Use Disorders.

PubMed

Polcin, Douglas L; Korcha, Rachael; Nayak, Madhabika

2018-06-01

Women have greater vulnerability to alcohol problems than men. They become intoxicated after drinking half as much as men, develop cirrhosis of the liver more rapidly, and have a greater risk of dying from alcohol-related accidents. Despite more serious consequences related to their drinking, treatment for women with alcohol use disorders has been understudied relative to treatment for men. Intensive motivational interviewing (IMI) is a recent psychotherapeutic intervention for substance abuse problems that draws on the principles of brief motivational interviewing (1-2 session). However, the intervention includes 9 sessions designed to enable therapists to have maximum flexibility to facilitate factors known to be important for women with substance use disorders, such as active facilitation of client-therapist collaboration, empowerment, and affirmation of strengths. This paper reviews the development of IMI, initial favorable findings for women with co-occurring methamphetamine and alcohol problems, and the design of an ongoing longitudinal study assessing the effects of MI for women with alcohol problems over a 12-month time period. Relational Theory is used as a conceptual framework for understanding IMI for women. The theory emphasizes understanding, building, and modifying interpersonal relationships as a central goal. From this perspective, self-efficacy, self-esteem, and reduction in drinking are enhanced through interpersonal connections with others. Plans for additional study of IMI are described along with suggestions for therapists.

Assembly, organization, and function of the COPII coat

PubMed Central

Hughes, Helen

2007-01-01

A full mechanistic understanding of how secretory cargo proteins are exported from the endoplasmic reticulum for passage through the early secretory pathway is essential for us to comprehend how cells are organized, maintain compartment identity, as well as how they selectively secrete proteins and other macromolecules to the extracellular space. This process depends on the function of a multi-subunit complex, the COPII coat. Here we describe progress towards a full mechanistic understanding of COPII coat function, including the latest findings in this area. Much of our understanding of how COPII functions and is regulated comes from studies of yeast genetics, biochemical reconstitution and single cell microscopy. New developments arising from clinical cases and model organism biology and genetics enable us to gain far greater insight in to the role of membrane traffic in the context of a whole organism as well as during embryogenesis and development. A significant outcome of such a full understanding is to reveal how the machinery and processes of membrane trafficking through the early secretory pathway fail in disease states. PMID:18060556

Toddlers' prosocial behavior: from instrumental to empathic to altruistic helping.

PubMed

Svetlova, Margarita; Nichols, Sara R; Brownell, Celia A

2010-01-01

The study explored how the meaning of prosocial behavior changes over toddlerhood. Sixty-five 18- and 30-month-olds could help an adult in 3 contexts: instrumental (action based), empathic (emotion based), and altruistic (costly). Children at both ages helped readily in instrumental tasks. For 18-month-olds, empathic helping was significantly more difficult than instrumental helping and required greater communication from the adult about her needs. Altruistic helping, which involved giving up an object of the child's own, was the most difficult for children at both ages. Findings suggest that over the 2nd year of life, prosocial behavior develops from relying on action understanding and explicit communications to understanding others' emotions from subtle cues. Developmental trajectories of social-cognitive and motivational components of early helping are discussed. © 2010 The Authors. Child Development © 2010 Society for Research in Child Development, Inc.

Cultural differences in asymmetric beliefs of interpersonal knowledge in vertical and horizontal relationships.

PubMed

Cho, Yohan; Otani, Hajime; Han, Kyunghee; Van Horn, K Roger

2010-01-01

Previous studies have reported that our interpersonal knowledge shows an asymmetry; that is, we tend to believe that we know and understand other people's thoughts and feelings better than other people know and understand our own thoughts and feelings. In the present study, the authors compared American (114 men, 192 women) and Korean (99 men and 98 women) students to examine whether the asymmetry is greater in collectivistic than in individualistic culture in two types of relationships: horizontal (with best friends) and vertical (with parents). On all three items--Know, Understand, and Visibility--asymmetry was found for both horizontal and vertical relationships. Further, the Understand and Visibility items showed greater asymmetry for the Korean group than for the American group. It was concluded that asymmetry is greater in collectivistic than in individualistic culture. The cultural differences can be explained by self-consistency, sensitivity to social consequences, parent-child interaction, and living arrangement.

Knowledge, attitudes, and perceptions of autism spectrum disorder in a stratified sampling of preschool teachers in China.

PubMed

Liu, Yingna; Li, Jialing; Zheng, Qiaolan; Zaroff, Charles M; Hall, Brian J; Li, Xiuhong; Hao, Yuantao

2016-05-13

In China, children with Autism Spectrum Disorder (ASD) can potentially benefit from universal education policies and recent initiatives designed to address the needs of children with developmental disorders. However, adequate schooling is often unavailable for children with ASD, in part because teachers lack the knowledge and skills needed to work with this population. To better understand the current state of knowledge of ASD in China, we surveyed knowledge and attitudes regarding the disorder in preschool teachers. A total of 471 preschool teachers in the cities of Guangzhou and Foshan, China completed questionnaires assessing participant demographics, knowledge of typical child development and knowledge of ASD, attitudes towards ASD, practices and self-perceptions of efficacy in the education of children with ASD, and awareness of organizations and intervention approaches devoted to the care of individuals with ASD. The correlation between individual- and school-level variables with current knowledge of typical child development and ASD was examined using univariate and multivariate analyses. The majority (84%) of participants answered correctly more than half of the questionnaire items assessing understanding of typical child development. In contrast, 83% provided inaccurate responses to more than half of the questionnaire items assessing knowledge of ASD. Knowledge of typical child development and knowledge of ASD were both associated with geographic region (teachers in Guangzhou had greater knowledge than those in Foshan, p < 0.0001). Knowledge of ASD was also associated with a higher education level (p < 0.05) and school type (p = 0.023). In general, participants believed fairly strongly in the need for greater service provision for children with ASD, and were receptive towards receiving additional specialized training. Most participants were unaware of ASD-specific organizations and empirically validated intervention approaches. Knowledge of ASD is lacking in preschool teachers in China, and greater teacher training and instruction is needed. Nonetheless, teachers report a willingness and motivation to gain the skills needed to maximize the educational experiences of children with ASD.

Market orientation: a concept for health libraries.

PubMed

Sen, Barbara

2006-03-01

This paper is the result of exploratory research forming part of ongoing study into the value and relevance of market orientation as a strategic option for library managers. The aim of the study is to gain an understanding of the concept of market orientation relative to the health library sector. A focus group was used to gather data from health librarians working at different levels in the sector. The data was coded and categorized by an expert panel and analysed using a taxonomic map developed during the study. Health library professionals define and understand market orientation in the same way as the concept is defined in the management literature. Their understanding of the concept is developing. A greater emphasis is given to some aspects of market orientation than others. There are implications for further research. Methods used to measure market orientation in other domains are likely to be relevant for libraries. Research should be extended to different sectors to explore any cross-sector differences. Fostering an organizational culture that supports market orientation has implications for service management and development.

Development of a frailty framework among vulnerable populations.

PubMed

Salem, Benissa E; Nyamathi, Adeline; Phillips, Linda R; Mentes, Janet C; Sarkisian, Catherine; Brecht, Mary-Lynn

2014-01-01

Frailty is a public health issue that is experienced by homeless and other vulnerable populations; to date, a frailty framework has not been proposed to guide researchers who study hard-to-reach populations. The Frailty Framework among Vulnerable Populations has been developed from empirical research and consultation with frailty experts in an effort to characterize antecedents, that is, situational, health-related, behavioral, resource, biological, and environmental factors that contribute to physical, psychological, and social frailty domains and impact adverse outcomes. As vulnerable populations continue to age, a greater understanding of frailty will enable the development of nursing interventions.

FY2011 Advanced Power Electronics and Electric Motors Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, Susan A.

The Advanced Power Electronics and Electric Motors (APEEM) program within the DOE Vehicle Technologies Program (VTP) provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE), electric motor (EM), thermal management, and traction drive system technologies that will leapfrog current on-the-road technologies. The research and development (R&D) is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow’s automobiles will function as a unified system to improve fuel efficiency.

Physiological Reactivity to Psychological Stress in Human Pregnancy: Current Knowledge and Future Directions

PubMed Central

Christian, Lisa M.

2012-01-01

Cardiovascular and neuroendocrine reactivity to acute stress are important predictors of health outcomes in non-pregnant populations. Greater magnitude and duration of physiological responses have been associated with increased risk of hypertensive disorders and diabetes, greater susceptibility to infectious illnesses, suppression of cell-mediated immunity as well as risk for depression and anxiety disorders. Stress reactivity during pregnancy has unique implications for maternal health, birth outcomes, and fetal development. However, as compared to the larger literature, our understanding of the predictors and consequences of exaggerated stress reactivity in pregnancy is limited. This paper reviews the current state of this literature with an emphasis on gaps in knowledge and future directions. PMID:22800930

Geophysical Survey of Poverty Point UNESCO World Heritage Site Mound A

NASA Astrophysics Data System (ADS)

Frazer, W.; Bourke, J. R.; De Smet, T.; Nikulin, A.

2017-12-01

Poverty Point is an UNESCO World Heritage Site located in northern Louisiana, known for its six earthwork ridges and mounds of archeological significance. The largest of these earthworks and most significant feature on the site, Mound A is over 70 feet (21 m) high and 640 feet (200 m) long. To construct this mound, it would have taken about 16 million basket loads of dirt which weight approximately 50 lbs. each (23 kg). The current archeological theory describing the construction of Mound A states it was built in three months at most, with some suggesting construction times as short as a month, but beyond this not much else is known about Mound A or Poverty Point. The pace of Mound A's construction has been used as evidence to support the idea that there was a central leader directing its construction and that the population inhabiting the site was more socio-politically complex than previous hunter-gatherer populations in North America. Evidence of heterogeneity and stratigraphic layering, however, is an indication of a slow mound construction over centuries by a relatively egalitarian hunter-gather society. A greater understanding of the construction style and timeline for the construction of Mound A will lead to a greater understanding to the site, its people their lifestyles. Mound Builders have been known to cap mounds they have built if they were to be built in stages so if Mound A was built in stages it is likely capped with some more dense material than the dirt surrounding it. To better understand the construction history of Mound A we collected photogrammetry, seismic reflection, ground-penetrating radar, frequency-domain electromagnetic-induction, resistivity, and magnetometry data over the mound. The seismic data had a normal moveout correction, it was stacked and migrated. Additionally, with the application of quadcopter-based photogrammetry a three-dimensional digital model of Mound A was developed to display and assist in further understanding and dissemination of these data. With greater knowledge of the composition and construction of Mound A at Poverty Point will give greater insight to the people of who built it and their way of life.

Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases.

PubMed

Oh, Soo Jin; Choi, Young Ki; Shin, Ok Sarah

2018-03-01

Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply systems biology methods to analyze immune responses to a variety of pathogens and vaccines. Despite recent advances, computational and biological challenges impede wider application of systems biology approaches. This review highlights recent advances in the fields of systems immunology and vaccinology, and presents ways that systems biology-based platforms can be applied to accelerate a deeper understanding of the molecular mechanisms of immunity against EIDs. © Copyright: Yonsei University College of Medicine 2018.

Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases

PubMed Central

2018-01-01

Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply systems biology methods to analyze immune responses to a variety of pathogens and vaccines. Despite recent advances, computational and biological challenges impede wider application of systems biology approaches. This review highlights recent advances in the fields of systems immunology and vaccinology, and presents ways that systems biology-based platforms can be applied to accelerate a deeper understanding of the molecular mechanisms of immunity against EIDs. PMID:29436184

Taking Venus models to new dimensions.

NASA Astrophysics Data System (ADS)

Murawski, K.

1997-11-01

Space plasma physicists in Poland and Japan have gained new insights into the interaction between the solar wind and Venus. Computer simulations of this 3D global interaction between the solar wind and nonmagnetized bodies have enabled greater understanding of the large-scale processes involved in such phenomena. A model that offers improved understanding of the solar wind interaction with Venus (as well as other nonmagnetized bodies impacted by the solar wind) has been developed. In this model, the interaction of the solar wind with the ionosphere of Venus is studied by calculating numerical solutions of the 3D MHD equations for two-component, chemically reactive plasma. The author describes the innovative model.

Large Mass, Entry, Descent and Landing Sensitivity Results for Environmental, Performance, and Design Parameters

NASA Technical Reports Server (NTRS)

Shidner, Jeremy D.; Davis, Jody L.; Cianciolo, Alicia D.; Samareh, Jamshid A.; Powell, RIchard W.

2010-01-01

Landing on Mars has been a challenging task. Past NASA missions have shown resilience to increases in spacecraft mass by scaling back requirements such as landing site altitude, landing site location and arrival time. Knowledge of the partials relating requirements to mass is critical for mission designers to understand so that the project can retain margin throughout the process. Looking forward to new missions that will land 1.5 metric tons or greater, the current level of technology is insufficient, and new technologies will need to be developed. Understanding the sensitivity of these new technologies to requirements is the purpose of this paper.

Neural responses to macronutrients: hedonic and homeostatic mechanisms.

PubMed

Tulloch, Alastair J; Murray, Susan; Vaicekonyte, Regina; Avena, Nicole M

2015-05-01

The brain responds to macronutrients via intricate mechanisms. We review how the brain's neural systems implicated in homeostatic control of feeding and hedonic responses are influenced by the ingestion of specific types of food. We discuss how these neural systems are dysregulated in preclinical models of obesity. Findings from these studies can increase our understanding of overeating and, perhaps in some cases, the development of obesity. In addition, a greater understanding of the neural circuits affected by the consumption of specific macronutrients, and by obesity, might lead to new treatments and strategies for preventing unhealthy weight gain. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Earth materials research: Report of a Workshop on Physics and Chemistry of Earth Materials

NASA Technical Reports Server (NTRS)

1987-01-01

The report concludes that an enhanced effort of earth materials research is necessary to advance the understanding of the processes that shape the planet. In support of such an effort, there are new classes of experiments, new levels of analytical sensitivity and precision, and new levels of theory that are now applicable in understanding the physical and chemical properties of geological materials. The application of these capabilities involves the need to upgrade and make greater use of existing facilities as well as the development of new techniques. A concomitant need is for a sample program involving their collection, synthesis, distribution, and analysis.

Feelings of Gratitude Toward God Among Older Whites, Older African Americans, and Older Mexican Americans

PubMed Central

Krause, Neal

2011-01-01

The first goal of this study is to see if social relationships in the church influence feelings of gratitude toward God. The second goal is to assess the impact of race and ethnicity on this relationship. The data support the following hypotheses: (1) older people who go to church more often tend to receive more spiritual support from fellow church members; (2) older adults who receive more spiritual support at church will derive a deeper understanding of themselves and others; (3) older people who develop greater insight into themselves and others will derive a greater sense of religious meaning in life; and (4) older adults who develop a deeper sense of religious meaning in life will feel more grateful to God. The results also indicate that the study model explains how feelings of gratitude toward God arise among older blacks and whites, but not older Mexican Americans. PMID:23543840

Disparate stakeholder management: the case of elk and bison feeding in southern Greater Yellowstone

USGS Publications Warehouse

Koontz, Lynne; Hoag, Dana; DeLong, Don

2012-01-01

For resource decisions to make the most possible progress toward achieving agency mandates, managers must work with stakeholders and may need to at least partially accommodate some of their key underlying interests. To accommodate stakeholder interests, while also substantively working toward fulfilling legal mandates, managers must understand the sociopolitical factors that influence the decision-making process. We coin the phrase disparate stakeholder management (DSM) to describe situations with disparate stakeholders and disparate management solutions. A DSM approach (DSMA) requires decision makers to combine concepts from many sciences, thus releasing them from disciplinary bonds that often constrain innovation and effectiveness. We combined three distinct approaches to develop a DSMA that assisted in developing a comprehensive range of elk and bison management alternatives in the Southern Greater Yellowstone Area. The DSMA illustrated the extent of compromise between meeting legal agency mandates and accommodating the preferences of certain stakeholder groups.

Feelings of Gratitude Toward God Among Older Whites, Older African Americans, and Older Mexican Americans.

PubMed

Krause, Neal

2012-03-01

The first goal of this study is to see if social relationships in the church influence feelings of gratitude toward God. The second goal is to assess the impact of race and ethnicity on this relationship. The data support the following hypotheses: (1) older people who go to church more often tend to receive more spiritual support from fellow church members; (2) older adults who receive more spiritual support at church will derive a deeper understanding of themselves and others; (3) older people who develop greater insight into themselves and others will derive a greater sense of religious meaning in life; and (4) older adults who develop a deeper sense of religious meaning in life will feel more grateful to God. The results also indicate that the study model explains how feelings of gratitude toward God arise among older blacks and whites, but not older Mexican Americans.

Driving and Neurodegenerative Diseases

PubMed Central

Uc, Ergun Y.; Rizzo, Matthew

2011-01-01

The proportion of elderly in the general population is rising, resulting in greater numbers of drivers with neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). These neurodegenerative disorders impair cognition, visual perception, and motor function, leading to reduced driver fitness and greater crash risk. Yet medical diagnosis or age alone is not reliable enough to predict driver safety or crashes, or revoke the driving privileges of these drivers. Driving research utilizes tools such as questionnaires about driving habits and history, driving simulators, standardized road tests utilizing instrumented vehicles, and state driving records. Research challenges include outlining the evolution of driving safety, understanding the mechanisms of driving impairment, and developing a reliable and efficient standardized test battery for prediction of driver safety in neurodegenerative disorders. This information will enable healthcare providers to advise their patients with neurodegenerative disorders with more certainty, affect policy, and help to develop rehabilitative measures for driving. PMID:18713573

Latest trends in craniomaxillofacial surgical instrumentation.

PubMed

Yim, Michael; Demke, Joshua

2012-08-01

To review the past year's literature regarding recent innovations in surgical instrumentation for craniomaxillofacial surgery. Current advances in surgical instrumentation have led to many improvements in the field, allowing greater visualization and precision both before and during procedures. One of the common goals is to achieve excellent outcomes with minimal complications, while at the same time minimizing invasiveness of surgery. Highlighted innovations include greater capacities for acquisition of data, leading to improved imaging modalities and expansion of computer-assisted surgical techniques; continued developments in biomaterials used in various reconstructions; and novel uses of bone cutting and bone fixation instrumentation. Technology in the field of craniomaxillofacial surgery is developing rapidly, leading to novel instrumentation being utilized across a broad spectrum of areas. Published data have been encouraging to date, indicating an ever increasing adaptation of these innovations in clinical practice. Future efforts need to focus on cost-benefit analysis and constructing larger-scale studies to better understand effectiveness and patient outcomes.

Functional Differences Between Placental Micro- and Macrovascular Endothelial Colony-Forming Cells

PubMed Central

Solomon, Ioana; O’Reilly, Megan; Ionescu, Lavinia; Alphonse, Rajesh S.; Rajabali, Saima; Zhong, Shumei; Vadivel, Arul; Shelley, W. Chris; Yoder, Mervin C.

2016-01-01

Alterations in the development of the placental vasculature can lead to pregnancy complications, such as preeclampsia. Currently, the cause of preeclampsia is unknown, and there are no specific prevention or treatment strategies. Further insight into the placental vasculature may aid in identifying causal factors. Endothelial colony-forming cells (ECFCs) are a subset of endothelial progenitor cells capable of self-renewal and de novo vessel formation in vitro. We hypothesized that ECFCs exist in the micro- and macrovasculature of the normal, term human placenta. Human placentas were collected from term pregnancies delivered by cesarean section (n = 16). Placental micro- and macrovasculature was collected from the maternal and fetal side of the placenta, respectively, and ECFCs were isolated and characterized. ECFCs were CD31+, CD105+, CD144+, CD146+, CD14−, and CD45−, took up 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate-labeled acetylated low-density lipoprotein, and bound Ulex europaeus agglutinin 1. In vitro, macrovascular ECFCs had a greater potential to generate high-proliferative colonies and formed more complex capillary-like networks on Matrigel compared with microvascular ECFCs. In contrast, in vivo assessment demonstrated that microvascular ECFCs had a greater potential to form vessels. Macrovascular ECFCs were of fetal origin, whereas microvascular ECFCs were of maternal origin. ECFCs exist in the micro- and macrovasculature of the normal, term human placenta. Although macrovascular ECFCs demonstrated greater vessel and colony-forming potency in vitro, this did not translate in vivo, where microvascular ECFCs exhibited a greater vessel-forming ability. These important findings contribute to the current understanding of normal placental vascular development and may aid in identifying factors involved in preeclampsia and other pregnancy complications. Significance This research confirms that resident endothelial colony-forming cells (ECFCs) exist in the micro- and macrovasculature of the normal, term human placenta. Their isolation from two different anatomical locations yields two functionally different ECFC populations. Investigation of these ECFC populations during placental pathologies, such as preeclampsia, may lead to a better understanding of the disease process and aid in developing new therapies. PMID:26819255

Assessing the Substitutability of Surrogate Measures of Job Performance of Hands-On Work Sample Tests

DTIC Science & Technology

1992-06-01

surrogate of .90 be a criterion for initially identifying substitutability. Gottfredson (1986) provides additional guidance for making comparison among... intelligence and reading level, for example, may yield a greater understanding of the general conditions that facilitate development and applicability of...noted by Gottfredson (1986), different measures may be required for different classes of jobs due to systematic differences in job demands, and these

Penetration into Granular Earth Materials (Topic H): A Multi-scale Physics-Based Approach Towards Developing a Greater Understanding of Dynamically Loaded Heterogeneous Systems

DTIC Science & Technology

2016-08-01

7 2.1. DYNAMIC DART GUN EXPERIMENTS...penetration, and cavity formation associated with high-speed projectile penetration of sand. A new half-inch gun was constructed for this project. A...inch gun with them. Data was collected utilizing NSWC’s Cordin 550, 64 frame, high-speed camera. In addition, several student participated in the

Application of a stochastic snowmelt model for probabilistic decisionmaking

NASA Technical Reports Server (NTRS)

Mccuen, R. H.

1983-01-01

A stochastic form of the snowmelt runoff model that can be used for probabilistic decision-making was developed. The use of probabilistic streamflow predictions instead of single valued deterministic predictions leads to greater accuracy in decisions. While the accuracy of the output function is important in decisionmaking, it is also important to understand the relative importance of the coefficients. Therefore, a sensitivity analysis was made for each of the coefficients.

Marketing the gastrointestinal practice: strategic considerations.

PubMed

Berkowitz, Eric N

2006-10-01

The health care marketplace is changing rapidly with increasing competition, changing reimbursement, and greater shifting of cost to patients making them more price sensitive. To be financially viable, the successful gastrointestinal practice must be more market responsive in its approach to planning, develop a unique advantage that will be of value to referral sources, and understand how customers evaluate alternative competing practices. This article focuses on these elements of practice success.

Uncovering the Role of BMP Signaling in Melanocyte Development and Melanoma Tumorigenesis

DTIC Science & Technology

2015-06-01

Undergrad. student 2013 (W. New England University) Dissertation committees: Shawna Guillemette, UMass Medical School, Cancer Biology Program Tomoko...SUPPLEMENTARY NOTES 14. ABSTRACT Melanoma is the most aggressive and lethal form of skin cancer . In 2013 over 75,000 Americans were diagnosed with...skin cancer , and every year it kills nearly 10,000 Americans and roughly 60,000 people worldwide. A greater understanding of the genetic basis for

Annual Research Review: New Frontiers in Developmental Neuropharmacology--Can Long-Term Therapeutic Effects of Drugs Be Optimized through Carefully Timed Early Intervention?

ERIC Educational Resources Information Center

Andersen, Susan L.; Navalta, Carryl P.

2011-01-01

Our aim is to present a working model that may serve as a valuable heuristic to predict enduring effects of drugs when administered during development. Our primary tenet is that a greater understanding of neurodevelopment can lead to improved treatment that intervenes early in the progression of a given disorder and prevents symptoms from…

Vestibulo-ocular reflex function in children with high-functioning autism spectrum disorders.

PubMed

Carson, Tana B; Wilkes, Bradley J; Patel, Kunal; Pineda, Jill L; Ko, Ji H; Newell, Karl M; Bodfish, James W; Schubert, Michael C; Radonovich, Krestin; White, Keith D; Lewis, Mark H

2017-02-01

Sensorimotor processing alterations are a growing focus in the assessment and treatment of Autism Spectrum Disorders (ASD). The rotational vestibulo-ocular reflex (rVOR), which functions to maintain stable vision during head movements, is a sensorimotor system that may be useful in understanding such alterations and their underlying neurobiology. In this study, we assessed post-rotary nystagmus elicited by continuous whole body rotation among children with high-functioning ASD and typically developing children. Children with ASD exhibited increased rVOR gain, the ratio of eye velocity to head velocity, indicating a possible lack of cerebellar inhibitory input to brainstem vestibular nuclei in this population. The ASD group also showed less regular or periodic horizontal eye movements as indexed by greater variance accounted for by multiple higher frequency bandwidths as well as greater entropy scores compared to typically developing children. The decreased regularity or dysrhythmia in the temporal structure of nystagmus beats in children with ASD may be due to alterations in cerebellum and brainstem circuitry. These findings could potentially serve as a model to better understand the functional effects of differences in these brain structures in ASD. Autism Res 2017, 10: 251-266. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Toddlers' Prosocial Behavior: From Instrumental to Empathic to Altruistic Helping

PubMed Central

Svetlova, Margarita; Nichols, Sara R.; Brownell, Celia A.

2010-01-01

The study explored how the meaning of prosocial behavior changes over toddlerhood. Sixty-five 18- and 30-month-olds could help an adult in three contexts: instrumental (action-based), empathic (emotion-based) and altruistic (costly). Children at both ages helped readily in instrumental tasks. For 18-month-olds, empathic helping was significantly more difficult than instrumental helping and required greater communication from the adult about her needs. Altruistic helping, which involved giving up an object of the child's own, was the most difficult for children at both ages. Findings suggest that over the second year of life, prosocial behavior develops from relying on action understanding and explicit communications to understanding others' emotions from subtle cues. Developmental trajectories of social-understanding and motivational components of early helping are discussed. PMID:21077866

Parental influences of sexual risk among urban African American adolescent males.

PubMed

Harris, Allyssa L; Sutherland, Melissa A; Hutchinson, M Katherine

2013-06-01

This study examined the influence of parental marital status, parent-child sexual communication, parent-child closeness on the HIV-related knowledge, safer-sex intentions, and behaviors of late adolescent urban African American males. The study employed a cross-sectional design with retrospective recall of salient parental influences and behaviors. Data were collected via paper-and-pencil questionnaire from 134 late adolescent African American males, 18 to 22 years of age, recruited from urban communities in and around Boston, Massachusetts. Data were analyzed using bivariate correlations, paired t tests, and regression modeling. Young men reported greater amounts of sexual communication with mothers than fathers (p < .001). Parent-child closeness was positively correlated with amount of parent-child sexual communication with both mothers and fathers (p < .001 for both). Parent-child closeness was, in turn, associated with greater condom use self-efficacy (p < .01), less permissive sexual attitudes (p < .001), fewer sexual partners (p < .01), and less unprotected sex (p < .01). Greater amounts of parent-child sexual communication were associated with fewer sexual risk behaviors, more consistent condom use, and greater intentions to use condoms in the future. There was evidence that parental influences on sexual risk behaviors and condom use intentions were mediated through young men's condom use self-efficacy, attitudes, and beliefs. These findings highlight the importance of the parent-child relationship and the role of parent-child communication between parents and sons. Further studies are needed to better understand the nature of father-son communication and develop strategies to help parents communicate effectively with sons. Evidence has shown that African American adolescent males are more likely to engage in high-risk sexual behaviors. Understanding the sexual risk communication between African American adolescent males and their parents is important to developing strategies in reducing sexual risk behavior. © 2013 Sigma Theta Tau International.

Emotional predictors of bowel screening: the avoidance-promoting role of fear, embarrassment, and disgust.

PubMed

Reynolds, Lisa M; Bissett, Ian P; Consedine, Nathan S

2018-05-03

Despite considerable efforts to address practical barriers, colorectal cancer screening numbers are often low. People do not always act rationally, and investigating emotions may offer insight into the avoidance of screening. The current work assessed whether fear, embarrassment, and disgust predicted colorectal cancer screening avoidance. A community sample (N = 306) aged 45+ completed a questionnaire assessing colorectal cancer screening history and the extent that perceptions of cancer risk, colorectal cancer knowledge, doctor discussions, and a specifically developed scale, the Emotional Barriers to Bowel Screening (EBBS), were associated with previous screening behaviours and anticipated bowel health decision-making. Step-wise logistic regression models revealed that a decision to delay seeking healthcare in the hypothetical presence of bowel symptoms was less likely in people who had discussed risk with their doctor, whereas greater colorectal cancer knowledge and greater fear of a negative outcome predicted greater likelihood of delay. Having previously provided a faecal sample was predicted by discussions about risk with a doctor, older age, and greater embarrassment, whereas perceptions of lower risk predicted a lower likelihood. Likewise, greater insertion disgust predicted a lower likelihood of having had an invasive bowel screening test in the previous 5 years. Alongside medical and demographic factors, fear, embarrassment and disgust are worthy of consideration in colorectal cancer screening. Understanding how specific emotions impact screening decisions and behaviour is an important direction for future work and has potential to inform screening development and communications in bowel health.

Mother- and Father-Reported Reactions to Children's Negative Emotions: Relations to Young Children's Emotional Understanding and Friendship Quality

PubMed Central

McElwain, Nancy L.; Halberstadt, Amy G.; Volling, Brenda L.

2008-01-01

Mother- and father-reported reactions to children's negative emotions were examined as correlates of emotional understanding (Study 1, N = 55, 5- to 6-year-olds) and friendship quality (Study 2, N = 49, 3- to 5-year-olds). Mothers' and fathers' supportive reactions together contributed to greater child-friend coordinated play during a sharing task. Further, when one parent reported low support, greater support by the other parent was related to better understanding of emotions and less intense conflict with friends (for boys only). When one parent reported high support, however, greater support by the other parent was associated with less optimal functioning on these outcomes. Results partially support the notion that children benefit when parents differ in their reactions to children's emotions. PMID:17883439

Advanced Mathematical Study and the Development of Conditional Reasoning Skills

PubMed Central

Attridge, Nina; Inglis, Matthew

2013-01-01

Since the time of Plato, philosophers and educational policy-makers have assumed that the study of mathematics improves one's general ‘thinking skills’. Today, this argument, known as the ‘Theory of Formal Discipline’ is used in policy debates to prioritize mathematics in school curricula. But there is no strong research evidence which justifies it. We tested the Theory of Formal Discipline by tracking the development of conditional reasoning behavior in students studying post-compulsory mathematics compared to post-compulsory English literature. In line with the Theory of Formal Discipline, the mathematics students did develop their conditional reasoning to a greater extent than the literature students, despite them having received no explicit tuition in conditional logic. However, this development appeared to be towards the so-called defective conditional understanding, rather than the logically normative material conditional understanding. We conclude by arguing that Plato may have been correct to claim that studying advanced mathematics is associated with the development of logical reasoning skills, but that the nature of this development may be more complex than previously thought. PMID:23869241

STEM Faculty as Learners in Pedagogical Reform and the Role of Research Articles as Professional Development Opportunities

PubMed Central

Mulnix, Amy B.

2016-01-01

Discipline-based education research (DBER) publications are opportunities for professional development around science, technology, engineering, and mathematics (STEM) education reform. Learning theory tells us these publications could be more impactful if authors, reviewers, and editors pay greater attention to linking principles and practice. This approach, which considers faculty as learners and STEM education reform as content, has the potential to better support faculty members because it promotes a deeper understanding of the reasons why a pedagogical change is effective. This depth of understanding is necessary for faculty members to successfully transfer new knowledge to their own contexts. A challenge ahead for the emergent learning sciences is to better integrate findings from across sister disciplines; DBER reports can take a step in that direction while improving their usefulness for instructors. PMID:27810872

Cognitive neuroscience 2.0: building a cumulative science of human brain function

PubMed Central

Yarkoni, Tal; Poldrack, Russell A.; Van Essen, David C.; Wager, Tor D.

2010-01-01

Cognitive neuroscientists increasingly recognize that continued progress in understanding human brain function will require not only the acquisition of new data, but also the synthesis and integration of data across studies and laboratories. Here we review ongoing efforts to develop a more cumulative science of human brain function. We discuss the rationale for an increased focus on formal synthesis of the cognitive neuroscience literature, provide an overview of recently developed tools and platforms designed to facilitate the sharing and integration of neuroimaging data, and conclude with a discussion of several emerging developments that hold even greater promise in advancing the study of human brain function. PMID:20884276

The Influence of Physical Qualities on Activity Profiles of Female Australian Football Match Play.

PubMed

Black, Georgia M; Gabbett, Tim J; Johnston, Rich D; Cole, Michael H; Naughton, Geraldine; Dawson, Brian

2018-04-01

The transition of female Australian football (AF) players from amateur to semielite competitions has the potential for athletes to be underprepared for match play. To gain an understanding of the match demands of female football, the aims of this study were to highlight the physical qualities that discriminate selected and nonselected female AF players, investigate activity profiles of female AF players, and gain an understanding of the influence of physical qualities on performance in female AF Methods: Twenty-two female AF state academy players (mean [SD]: age = 23.2 [4.5] y) and 27 nonselected players (mean [SD]: age = 23.4 [4.9] y) completed a Yo-Yo intermittent recovery test level 1, countermovement jump, and 30-m sprint tests were completed prior to the competitive season. During 14 matches, players wore global positioning system units to describe the running demands of match play. Selected players were faster over 30 m (ES = 0.57; P = .04) and covered greater distances on the Yo-Yo IR1 (ES = 1.09; P < .001). Selected midfielders spent greater time on the field and covered greater total distances (ES = 0.73-0.85; P < .01). Players faster over 5 m (r = -.612) and 30 m (r = -.807) and who performed better on the Yo-Yo IR1 (r = .489) covered greater high-speed distances during match play. An emphasis should be placed on the development of physical fitness in this playing group to ensure optimal preparation for the national competition.

Physiological reactivity to psychological stress in human pregnancy: current knowledge and future directions.

PubMed

Christian, Lisa M

2012-11-01

Cardiovascular and neuroendocrine reactivity to acute stress are important predictors of health outcomes in non-pregnant populations. Greater magnitude and duration of physiological responses have been associated with increased risk of hypertensive disorders and diabetes, greater susceptibility to infectious illnesses, suppression of cell-mediated immunity as well as risk for depression and anxiety disorders. Stress reactivity during pregnancy has unique implications for maternal health, birth outcomes, and fetal development. However, as compared to the larger literature, our understanding of the predictors and consequences of exaggerated stress reactivity in pregnancy is limited. This paper reviews the current state of this literature with an emphasis on gaps in knowledge and future directions. Copyright © 2012 Elsevier Ltd. All rights reserved.

Examining the Efficacy of a Tier 2 Kindergarten Mathematics Intervention.

PubMed

Clarke, Ben; Doabler, Christian T; Smolkowski, Keith; Baker, Scott K; Fien, Hank; Strand Cary, Mari

2016-01-01

This study examined the efficacy of a Tier 2 kindergarten mathematics intervention program, ROOTS, focused on developing whole number understanding for students at risk in mathematics. A total of 29 classrooms were randomly assigned to treatment (ROOTS) or control (standard district practices) conditions. Measures of mathematics achievement were collected at pretest and posttest. Treatment and control students did not differ on mathematics assessments at pretest. Gain scores of at-risk intervention students were significantly greater than those of control peers, and the gains of at-risk treatment students were greater than the gains of peers not at risk, effectively reducing the achievement gap. Implications for Tier 2 mathematics instruction in a response to intervention (RtI) model are discussed. © Hammill Institute on Disabilities 2014.

'Greater good' versus civil liberties in the United States: Tuberculosis and Seattle's Firland Sanatorium.

PubMed

Blackburn, Christine Crudo

2017-11-01

As far back as the late 1700s, peoples in the United States were developing ways to control infectious disease without infringing on Constitutional rights. Despite acknowledgement that an infected person has certain civil liberties, the history of public health law shows that, in many instances, infectious disease isolation and quarantine proved to be scientifically questionable at best. I examine an historical example of such questionable relationship between public health and civil liberties: the locked ward at Firland Sanatorium in Seattle, Washington. Mandatory quarantine at Firland began in the late 1940s and lasted until the facility closed in the early 1970s. Can examining this history enhance understanding of the relationship between "the greater good" and an individual's civil liberties?

Parental Problem Drinking, Marital Aggression, and Child Emotional Insecurity: A Longitudinal Investigation*

PubMed Central

Keller, Peggy S.; Gilbert, Lauren R.; Koss, Kalsea J.; Cummings, E. Mark; Davies, Patrick T.

2011-01-01

Objective: Marital aggression plays an important role in relations between parental problem drinking and child maladjustment. The purpose of the current study was to apply emotional security theory as a framework for understanding the role of marital aggression. Method: A community sample of 235 children in kindergarten participated once a year for 3 years. Parents completed measures of parental problem drinking and marital aggression, and children were interviewed about their emotional security reactions to marital conflict vignettes. Results: Greater parental problem drinking was directly associated with children's more negative emotional reactions to conflict. Maternal problem drinking predicted increased sad reactions and negative expectations for the future. Paternal problem drinking predicted increases in child anger reactions and negative expectations for the future. Parental problem drinking was also indirectly associated with child reactions via marital aggression. Conclusions: Results confirmed hypotheses that parental problem drinking would be related to child emotional insecurity and that associations would be indirect via greater marital conflict. Findings are interpreted in terms of emotional security theory as a framework for understanding the effects of parental problem drinking on marital aggression and child development. PMID:21906498

Parental problem drinking, marital aggression, and child emotional insecurity: a longitudinal investigation.

PubMed

Keller, Peggy S; Gilbert, Lauren R; Koss, Kalsea J; Cummings, E Mark; Davies, Patrick T

2011-09-01

Marital aggression plays an important role in relations between parental problem drinking and child maladjustment. The purpose of the current study was to apply emotional security theory as a framework for understanding the role of marital aggression. A community sample of 235 children in kindergarten participated once a year for 3 years. Parents completed measures of parental problem drinking and marital aggression, and children were interviewed about their emotional security reactions to marital conflict vignettes. Greater parental problem drinking was directly associated with children's more negative emotional reactions to conflict. Maternal problem drinking predicted increased sad reactions and negative expectations for the future. Paternal problem drinking predicted increases in child anger reactions and negative expectations for the future. Parental problem drinking was also indirectly associated with child reactions via marital aggression. Results confirmed hypotheses that parental problem drinking would be related to child emotional insecurity and that associations would be indirect via greater marital conflict. Findings are interpreted in terms of emotional security theory as a framework for understanding the effects of parental problem drinking on marital aggression and child development.

Human factors in modern traffic systems.

PubMed

Noy, Y I

1997-10-01

Traffic systems are undergoing enormous change with the advent of Intelligent Transport Systems (ITS). Although productivity and quality of mobility are emerging interests, safety remains the predominant preoccupation of ITS human factors. It should be evident that while intelligent technologies may have the potential to improve traffic safety, they also have the potential to adversely affect it. Ultimately, the effect on safety depends on the specific technologies that are invoked and the manner in which they are incorporated within the vehicle as well as within the larger road transportation system. Current automotive developments can be characterized as technology-centred solutions rather than user-centred solutions. Greater effort must be directed at understanding and accommodating the human element in the road transportation system in order that future transportation objectives can be achieved. There is a need to expand the scope of traditional human factors to include macro-level effects as well as to place greater emphasis on understanding human interactions with other elements of the system. There is also increasing recognition of the urgent need for systematic procedures and criteria for testing the safety of ITS prior to large-scale market penetration.

Nontechnical skill training and the use of scenarios in modern surgical education.

PubMed

Brunckhorst, Oliver; Khan, Muhammad S; Dasgupta, Prokar; Ahmed, Kamran

2017-07-01

Nontechnical skills are being increasingly recognized as a core reason of surgical errors. Combined with the changing nature of surgical training, there has therefore been an increase in nontechnical skill research in the literature. This review therefore aims to: define nontechnical skillsets, assess current training methods, explore assessment modalities and suggest future research aims. The literature demonstrates an increasing understanding of the components of nontechnical skills within surgery. This has led to a greater availability of validated training methods for its training, including the use of didactic teaching, e-learning and simulation-based scenarios. In addition, there are now various extensively validated assessment tools for nontechnical skills including NOTSS, the Oxford NOTECHS and OTAS. Finally, there is now more focus on the development of tools which target individual nontechnical skill components and an attempt to understand which of these play a greater role in specific procedures such as laparoscopic or robotic surgery. Current evidence demonstrates various training methods and tools for the training of nontechnical skills. Future research is likely to focus increasingly on individual nontechnical skill components and procedure-specific skills.

Associations between Breastfeeding and Maternal Responsiveness: A Systematic Review of the Literature12

PubMed Central

2017-01-01

Recent recommendations and prevention programs have focused on the promotion of responsive feeding during infancy, but more research is needed to understand best practices for fostering responsive feeding during early life. The objective of this systematic review was to synthesize the accumulating bodies of evidence aimed at understanding associations between mothers’ feeding experiences and responsive feeding in an attempt to clarify the nature of associations between feeding mode and responsive feeding. A literature search was conducted between January and October 2016; articles were collected from PsychINFO, Medline, and CINAHL, as well as from references in published research and reviews. Article inclusion criteria were as follows: 1) empirical research, 2) included a measure of infant feeding, 3) included a measure of maternal responsiveness, 4) study conducted in human participants, 5) available in English, and 6) study conducted in a developed and/or high-income country. Forty-three studies were identified. Cross-sectional observational studies consistently reported greater responsiveness among breastfeeding mothers than among formula-/bottle-feeding mothers. In addition, longitudinal studies showed that longer breastfeeding durations predicted lower use of nonresponsive feeding practices during later childhood, and some, but not all, found that breastfeeding mothers showed greater increases in responsiveness across infancy than did formula-/bottle-feeding mothers. However, a limited number of longitudinal studies also reported that greater responsiveness during early infancy predicted longer breastfeeding durations. A common limitation among these studies is the correlational nature of their designs and lack of prenatal measures of maternal responsiveness, which hinders our understanding of causal mechanisms. Although 2 randomized clinical trials aimed at promoting maternal responsiveness did not find effects of the intervention on breastfeeding outcomes, these findings were limited by the way in which breastfeeding outcomes were assessed. In sum, although there is consistent evidence for an association between breastfeeding and responsive feeding, more research is needed to better understand the mechanisms underlying this association. PMID:28507014

Associations between Breastfeeding and Maternal Responsiveness: A Systematic Review of the Literature.

PubMed

Ventura, Alison K

2017-05-01

Recent recommendations and prevention programs have focused on the promotion of responsive feeding during infancy, but more research is needed to understand best practices for fostering responsive feeding during early life. The objective of this systematic review was to synthesize the accumulating bodies of evidence aimed at understanding associations between mothers' feeding experiences and responsive feeding in an attempt to clarify the nature of associations between feeding mode and responsive feeding. A literature search was conducted between January and October 2016; articles were collected from PsychINFO, Medline, and CINAHL, as well as from references in published research and reviews. Article inclusion criteria were as follows: 1 ) empirical research, 2 ) included a measure of infant feeding, 3 ) included a measure of maternal responsiveness, 4 ) study conducted in human participants, 5 ) available in English, and 6 ) study conducted in a developed and/or high-income country. Forty-three studies were identified. Cross-sectional observational studies consistently reported greater responsiveness among breastfeeding mothers than among formula-/bottle-feeding mothers. In addition, longitudinal studies showed that longer breastfeeding durations predicted lower use of nonresponsive feeding practices during later childhood, and some, but not all, found that breastfeeding mothers showed greater increases in responsiveness across infancy than did formula-/bottle-feeding mothers. However, a limited number of longitudinal studies also reported that greater responsiveness during early infancy predicted longer breastfeeding durations. A common limitation among these studies is the correlational nature of their designs and lack of prenatal measures of maternal responsiveness, which hinders our understanding of causal mechanisms. Although 2 randomized clinical trials aimed at promoting maternal responsiveness did not find effects of the intervention on breastfeeding outcomes, these findings were limited by the way in which breastfeeding outcomes were assessed. In sum, although there is consistent evidence for an association between breastfeeding and responsive feeding, more research is needed to better understand the mechanisms underlying this association. © 2017 American Society for Nutrition.

Regimented research: a recipe for success?

PubMed

Yu, Eric H C

2003-04-01

Cardiology trainees at the University of Toronto participate annually in a mandatory research competition. Its purpose is to promote creative thinking, help develop a greater understanding of the scientific method and encourage them to pursue research as a career. Since its inception, this research competition's outcomes have not been assessed. This study set out to determine which components of a cardiology training program are important in the development of a career in cardiovascular research and addressed whether participation in this mandatory research competition was considered important to the development of a career in cardiovascular research. This study found that both faculty and trainees considered the following factors to be important in the development of a research career: (1) a mentor to provide support and guidance; (2) regular attendance at national and international meetings; (3) a fixed block of time within the training program dedicated solely to research activity; and (4) an academic environment that provides exposure to clinicians with varied research interests and ability. Neither trainees nor faculty believed that mandatory participation in a research competition was of significant benefit in the development of a research career, although faculty's perception of such a benefit was greater than the trainees'.

The Package-Based Development Process in the Flight Dynamics Division

NASA Technical Reports Server (NTRS)

Parra, Amalia; Seaman, Carolyn; Basili, Victor; Kraft, Stephen; Condon, Steven; Burke, Steven; Yakimovich, Daniil

1997-01-01

The Software Engineering Laboratory (SEL) has been operating for more than two decades in the Flight Dynamics Division (FDD) and has adapted to the constant movement of the software development environment. The SEL's Improvement Paradigm shows that process improvement is an iterative process. Understanding, Assessing and Packaging are the three steps that are followed in this cyclical paradigm. As the improvement process cycles back to the first step, after having packaged some experience, the level of understanding will be greater. In the past, products resulting from the packaging step have been large process documents, guidebooks, and training programs. As the technical world moves toward more modularized software, we have made a move toward more modularized software development process documentation, as such the products of the packaging step are becoming smaller and more frequent. In this manner, the QIP takes on a more spiral approach rather than a waterfall. This paper describes the state of the FDD in the area of software development processes, as revealed through the understanding and assessing activities conducted by the COTS study team. The insights presented include: (1) a characterization of a typical FDD Commercial Off the Shelf (COTS) intensive software development life-cycle process, (2) lessons learned through the COTS study interviews, and (3) a description of changes in the SEL due to the changing and accelerating nature of software development in the FDD.

Impaired Relational Organization of Propositions, but Intact Transitive Inference, in Aging: Implications for Understanding Underlying Neural Integrity

ERIC Educational Resources Information Center

Ryan, Jennifer D.; Moses, Sandra N.; Villate, Christina

2009-01-01

The ability to perform relational proposition-based reasoning was assessed in younger and older adults using the transitive inference task in which subjects learned a series of premise pairs (A greater than B, B greater than C, C greater than D, D greater than E, E greater than F) and were asked to make inference judgments (B?D, B?E, C?E).…

From the Canadian Dietetic Association. Concept of dietetic practice and framework for undergraduate education for the 21st century.

PubMed

McDonald, B E; Evers, S; Simard-Mavrikakis, S; Mendelson, R; Schweitzer, J; Smyth, L; Beaudry, M

1993-01-01

Rapid change and marked diversity are expected to characterize the 21st century. If dietitians are to serve as change facilitators in this environment they will have to demonstrate greater flexibility and creativity, practise critical analysis and problem solving and employ creative thinking. Although provision of quality nutrition care will remain the unique contribution of dietitians, practitioners in the future will require a greater understanding of the impact of social, economic and political systems on food availability and food consumption and, in turn, health and well-being. Critical to the future practice of dietetics will be a greater understanding of research methodology, computer technology, quality improvement processes and risk management, principles governing learning and behaviour, personnel management and organizational behaviour, family and group dynamics, interpersonal communication and their application to dietetic practice. The Canadian Dietetic Association recently adopted a framework for the development of baccalaureate programs in dietetics designed to enable the dietetic practitioner to continue to make a unique contribution in the 21st century. The framework allows individual institutions the freedom and flexibility to plan programs that are compatible with their philosophy and organizational structure. In addition, it is predicted on the principle that a career in dietetics entails a lifetime commitment to education, of which the baccalaureate program is only the beginning.

Numerical ordering of zero in honey bees.

PubMed

Howard, Scarlett R; Avarguès-Weber, Aurore; Garcia, Jair E; Greentree, Andrew D; Dyer, Adrian G

2018-06-08

Some vertebrates demonstrate complex numerosity concepts-including addition, sequential ordering of numbers, or even the concept of zero-but whether an insect can develop an understanding for such concepts remains unknown. We trained individual honey bees to the numerical concepts of "greater than" or "less than" using stimuli containing one to six elemental features. Bees could subsequently extrapolate the concept of less than to order zero numerosity at the lower end of the numerical continuum. Bees demonstrated an understanding that parallels animals such as the African grey parrot, nonhuman primates, and even preschool children. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Tick microbiome: the force within

PubMed Central

Narasimhan, Sukanya; Fikrig, Erol

2015-01-01

Ticks are obligate blood-feeders and serve as vectors of human and livestock pathogens worldwide. Defining the tick microbiome and deciphering the interactions between the tick and its symbiotic bacteria in the context of tick development and pathogen transmission, will likely reveal new insights and spawn new paradigms to control tick-borne diseases. Descriptive observations on the tick microbiome that began almost a century ago serve as forerunners to the gathering momentum to define the tick microbiome in greater detail. This review will focus on the current efforts to address the microbiomes of diverse ticks, and the evolving understanding of tick microbiomes. There is hope that these efforts will bring a holistic understanding of pathogen transmission by ticks. PMID:25936226

An Elective Course in Cultural Competence for Healthcare Professionals

PubMed Central

Evans, Emily

2006-01-01

Objectives To develop and assess a cultural competence elective course used to increase students’ levels of awareness, acceptance, and understanding of the role of culture on healthcare perceptions. Design Classroom and at-home assignments were designed, small group discussions were conducted, and guest speakers were recruited to allow students to explore different viewpoints about other cultures. Assessment Student performance was assessed based on assignments and participation in class discussions. Student satisfaction with the course was assessed using a standard course evaluation form. Conclusion Participation in the course resulted in greater student understanding of cultural issues facing healthcare providers and in students feeling more capable of integrating cultural factors into patient care. PMID:17136176

Understanding the experience of training for overseas nurses.

PubMed

Smith, Sally

To explore the perceptions of overseas nurses during their induction programme. A pilot cohort of 20 overseas nurses. A qualitative research approach was used. The key themes were: communication issues, culture, role definition and feelings of self-worth, which are interrelated and suggest how the experience has influenced each nurse's professional development and ultimate achievement of 'competence' as a registered nurse able to practise in the UK. These findings confirm there is a need for greater understanding of the 'adjustment process' and integration into the workforce. Recommendations are made that for future projects to succeed, comprehensive support frameworks are required to fully support both the overseas nurse and the organisation as a whole.

Why history matters to nursing.

PubMed

Holme, Annie

2015-05-01

This paper proposes that poor knowledge and understanding of the history of nursing particularly in the UK influences the media and public analysis of nursing practice. Comparing reports of current poor practice with a 'golden age' of nursing in the past undermines public confidence in today's nursing and nurse education and has the potential to lead to simplistic and flawed policy decisions in response. The lack of detailed knowledge of past nursing practice, experience and values suggests the need for more historical research in this field. A greater critical understanding of nursing history could strengthen and enrich nursing identity and further develop critical thinking skills in nursing students. Copyright © 2015 Elsevier Ltd. All rights reserved.

Quantifying benthic nitrogen fluxes in Puget Sound, Washington: a review of available data

USGS Publications Warehouse

Sheibley, Richard W.; Paulson, Anthony J.

2014-01-01

Understanding benthic fluxes is important for understanding the fate of materials that settle to the Puget Sound, Washington, seafloor, as well as the impact these fluxes have on the chemical composition and biogeochemical cycles of marine waters. Existing approaches used to measure benthic nitrogen flux in Puget Sound and elsewhere were reviewed and summarized, and factors for considering each approach were evaluated. Factors for selecting an appropriate approach for gathering information about benthic flux include: availability of resources, objectives of projects, and determination of which processes each approach measures. An extensive search of literature was undertaken to summarize known benthic nitrogen fluxes in Puget Sound. A total of 138 individual flux chamber measurements and 38 sets of diffusive fluxes were compiled for this study. Of the diffusive fluxes, 35 new datasets were located, and new flux calculations are presented in this report. About 65 new diffusive flux calculations are provided across all nitrogen species (nitrate, NO3-; nitrite, NO2-; ammonium, NH4+). Data analysis of this newly compiled benthic flux dataset showed that fluxes beneath deep (greater than 50 meters) water tended to be lower than those beneath shallow (less than 50 meters) water. Additionally, variability in flux at the shallow depths was greater, possibly indicating a more dynamic interaction between the benthic and pelagic environments. The overall range of bottom temperatures from studies in the Puget Sound area were small (5–16 degrees Celsius), and only NH4+ flux showed any pattern with temperature. For NH4+, flux values and variability increased at greater than about 12 degrees Celsius. Collection of additional study site metadata about environmental factors (bottom temperature, depth, sediment porosity, sediment type, and sediment organic matter) will help with development of a broader regional understanding benthic nitrogen flux in the Puget Sound.

Adult Development and Quality of Life of Transgender and Gender Nonconforming People

PubMed Central

Bockting, Walter; Coleman, Eli; Deutsch, Madeline B.; Guillamon, Antonio; Meyer, Ilan; Meyer, Walter; Reisner, Sari; Sevelius, Jae; Ettner, Randi

2016-01-01

Purpose of review Research on the health of transgender and gender nonconforming people has been limited with most of the work focusing on transition-related care and HIV. This review summarizes research to date on the overall development and quality of life of transgender and gender nonconforming adults, and makes recommendations for future research. Recent findings Pervasive stigma and discrimination attached to gender nonconformity affect the health of transgender people across the lifespan, particularly when it comes to mental health and wellbeing. Despite the related challenges, transgender and gender nonconforming people may develop resilience over time. Social support and affirmation of gender identity play herein a critical role. While there is a growing awareness of diversity in gender identity and expression among this population, a comprehensive understanding of biopsychosocial development beyond the gender binary and beyond transition is lacking. Summary Greater visibility of transgender people in society has revealed the need to understand and promote their health and quality of life broadly, including but not limited to gender dysphoria and HIV. This means addressing their needs in context of their families and communities, sexual and reproductive health, and successful aging. Research is needed to better understand what factors are associated with resilience and how it can be effectively promoted. PMID:26835800

Adult development and quality of life of transgender and gender nonconforming people.

PubMed

Bockting, Walter; Coleman, Eli; Deutsch, Madeline B; Guillamon, Antonio; Meyer, Ilan; Meyer, Walter; Reisner, Sari; Sevelius, Jae; Ettner, Randi

2016-04-01

Research on the health of transgender and gender nonconforming people has been limited with most of the work focusing on transition-related care and HIV. The present review summarizes research to date on the overall development and quality of life of transgender and gender nonconforming adults, and makes recommendations for future research. Pervasive stigma and discrimination attached to gender nonconformity affect the health of transgender people across the lifespan, particularly when it comes to mental health and well-being. Despite the related challenges, transgender and gender nonconforming people may develop resilience over time. Social support and affirmation of gender identity play herein a critical role. Although there is a growing awareness of diversity in gender identity and expression among this population, a comprehensive understanding of biopsychosocial development beyond the gender binary and beyond transition is lacking. Greater visibility of transgender people in society has revealed the need to understand and promote their health and quality of life broadly, including but not limited to gender dysphoria and HIV. This means addressing their needs in context of their families and communities, sexual and reproductive health, and successful aging. Research is needed to better understand what factors are associated with resilience and how it can be effectively promoted.

Why Do Only Some Hyperopes Become Strabismic?

PubMed Central

Babinsky, Erin; Candy, T. Rowan

2013-01-01

Children with hyperopia greater than +3.5 diopters (D) are at increased risk for developing refractive esotropia. However, only approximately 20% of these hyperopes develop strabismus. This review provides a systematic theoretical analysis of the accommodation and vergence oculomotor systems with a view to understanding factors that could either protect a hyperopic individual or precipitate a strabismus. The goal is to consider factors that may predict refractive esotropia in an individual and therefore help identify the subset of hyperopes who are at the highest risk for this strabismus, warranting the most consideration in a preventive effort PMID:23883788

Identifying Frailty Among Vulnerable Populations

PubMed Central

Salem, Benissa E.; Nyamathi, Adeline; Phillips, Linda R.; Mentes, Janet; Sarkisian, Catherine; Brecht, Lynn

2014-01-01

Frailty is a significant public health issue which is experienced by homeless and other vulnerable adults; to date, a frailty framework has not been proposed to guide researchers who study this hard-to-reach population. The Frailty Framework among Homeless and other Vulnerable Populations (FFHVP) has been developed from empirical research and consultation with frailty experts in an effort to characterize antecedents, i.e. situational, health-related, behavioral, resource, biological, and environmental factors which contribute to physical, psychological and social frailty domains and impact adverse outcomes. As vulnerable populations continue to age, a greater understanding of frailty will enable the development of nursing interventions. PMID:24469090

Promoting research on research integrity in Canada.

PubMed

Master, Zubin; McDonald, Michael; Williams-Jones, Bryn

2012-01-01

Research on research integrity is an important element in building a strong national research integrity framework. There is a lack of empirical evidence and conceptual research on research integrity in Canada. To further strengthen and develop our system of research integrity, we believe that greater support is needed to promote research on research integrity. Research on research integrity is imperative in order to gain a richer understanding of the diversity of responsible conduct of research norms, practices, education and policies from a Canadian perspective. The knowledge gained would help in the development of an evidenced-based and responsive Canadian system of research integrity.

From Flavr Savr Tomatoes to Stem Cell Therapy: Young People's Understandings of Gene Technology, 15 Years on

NASA Astrophysics Data System (ADS)

Lewis, Jenny

2014-02-01

This paper explores knowledge and understanding of basic genetics and gene technologies in school students who have been taught to a `science for all' National Curriculum and compares 482 students in 1995 (gene technology was a new and rapidly developing area of science with potential to impact on everyday life; the first cohort of students had been taught to the National Curriculum for Science) with 154 students in 2011 (genomics had replaced gene technology as a rapidly developing area of science with potential to impact on everyday life; science as a core subject within the National Curriculum was well established). These studies used the same questions, with the same age group (14-16) across the same (full) ability range; in addition the 2011 sample were asked about stem cells, stem cell technology and epigenetics. Students in 2011 showed: better knowledge of basic genetics but continuing difficulty in developing coherent explanatory frameworks; a good understanding of the nature of stem cells but no understanding of the process by which such cells become specialised; better understanding of different genetic technologies but also a wider range of misunderstandings and confusions (both between different genetic technologies and with other biological processes); continuing difficulty in evaluating potential veracity of short `news' items but greater awareness of ethical issues and the range of factors (including knowledge of genetics) which could be drawn on when justifying a view or coming to a decision. Implications for a `science for all' curriculum are considered.

A Data-Centric Strategy for Modern Biobanking.

PubMed

Quinlan, Philip R; Gardner, Stephen; Groves, Martin; Emes, Richard; Garibaldi, Jonathan

2015-01-01

Biobanking has been in existence for many decades and over that time has developed significantly. Biobanking originated from a need to collect, store and make available biological samples for a range of research purposes. It has changed as the understanding of biological processes has increased and new sample handling techniques have been developed to ensure samples were fit-for-purpose.As a result of these developments, modern biobanking is now facing two substantial new challenges. Firstly, new research methods such as next generation sequencing can generate datasets that are at an infinitely greater scale and resolution than previous methods. Secondly, as the understanding of diseases increases researchers require a far richer data set about the donors from which the sample originate.To retain a sample-centric strategy in a research environment that is increasingly dictated by data will place a biobank at a significant disadvantage and even result in the samples collected going unused. As a result biobanking is required to change strategic focus from a sample dominated perspective to a data-centric strategy.

Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy

PubMed Central

Haque, Sulsal; Yellu, Mahender; Randhawa, Jaskirat; Hashemi-Sadraei, Nooshin

2017-01-01

Head and neck squamous cell cancer (HNSCC) is the sixth most common malignancy worldwide, and despite advances in cytotoxic, surgical and radiation techniques, outcomes are still poor in those with both locally advanced and metastatic diseases. The need for development of better therapeutics along with a greater understanding of the relationship between the immune system and malignancies has led to a new therapeutic modality, immune modulators, particularly checkpoint inhibitors in HNSCC. It is now well recognized that HNSCC circumvents crucial pathways utilized by the immune system to escape surveillance. These hijacked pathways include impairing tumor antigen presentation machinery and co-opting checkpoint receptors. This understanding has led to the development of monoclonal antibodies targeting checkpoint receptors and has resulted in promising outcomes in HNSCC. This article describes the mechanisms that HNSCC utilizes to escape immune surveillance, clinical impact of checkpoint inhibitors (with a focus on pembrolizumab), ongoing studies, and future directions. PMID:28919706

Medical Situational Awareness in Theater Advanced Concept Technology Demonstration Project Proposal

DTIC Science & Technology

2004-06-01

making it an impossible task to sort, understand , and generate actionable knowledge within operational timeframes. Medical Situational Awareness in...need for greater medical situation awareness in theater and for greater integration of theater medical information into the net-centric rapid...There is a need for greater Medical Situation Awareness in theater and for greater integration of theater medical information into the ForceNet

Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis

PubMed Central

Rohmer, Laurence; Hocquet, Didier; Miller, Samuel I.

2011-01-01

It is interesting to speculate that the evolutionary drive of microbes to develop pathogenic characteristics was to access the nutrient resources that animals provided. Environments in animals that pathogens colonize have also driven the evolution of new bacterial characteristics to maximize these new nutritional opportunities. This review focuses on genomic and functional aspects of pathogen metabolism that allow efficient utilization of nutrient resources provided by animals. Similar to genes encoding specific virulence traits, some genes encoding metabolic functions have been horizontally acquired by pathogens to provide a selective advantage in host tissues. Selective advantage in host tissues can also be gained in some circumstances by loss of function due to mutations that alter metabolic capabilities. Greater understanding of bacterial metabolism within host tissues should be important for increased understanding of host-pathogen interactions and the development of future therapeutic strategies. PMID:21600774

Physician's emerging roles relating to trends in health information technology.

PubMed

David Johnson, J

2014-08-12

Objective: To determine the new roles that physicians will adopt in the near future to adjust to accelerating trends from managed care to outcome-based practice to health care reform to health information technology to the evolving role of health consumers. Methods: Trends and related developments concerning the changing roles of physicians based on prior literature reviews. Results: Six possible roles, traditional, gatekeeper, coach, navigator, informatician and one voice among many, are discussed in terms of physician's centrality, patient autonomy, decision-making and uncertainty, information seeking, satisfaction and outcomes, particularly those related to compliance. Conclusion: A greater understanding of these emerging roles could lead to more efficacious outcomes in our ever changing, increasingly complex medical system. Patients often have little understanding of emerging trends that lead to the development of specialized roles such as hospitalist and navigators and, relatedly, the evolving roles of physicians.

Earth Observations in Support of Offshore Wind Energy Management in the Euro-Atlantic Region

NASA Astrophysics Data System (ADS)

Liberato, M. L. R.

2017-12-01

Climate change is one of the most important challenges in the 21st century and the energy sector is a major contributor to GHG emissions. Therefore greater attention has been given to the evaluation of offshore wind energy potentials along coastal areas, as it is expected offshore wind energy to be more efficient and cost-effective in the near future. Europe is developing offshore sites for over two decades and has been growing at gigawatt levels in annual capacity. Portugal is among these countries, with the development of a 25MW WindFloat Atlantic wind farm project. The international scientific community has developed robust ability on the research of the climate system components and their interactions. Climate scientists have gained expertise in the observation and analysis of the climate system as well as on the improvement of model and predictive capabilities. Developments on climate science allow advancing our understanding and prediction of the variability and change of Earth's climate on all space and time scales, while improving skilful climate assessments and tools for dealing with future challenges of a warming planet. However the availability of greater datasets amplifies the complexity on manipulation, representation and consequent analysis and interpretation of such datasets. Today the challenge is to translate scientific understanding of the climate system into climate information for society and decision makers. Here we discuss the development of an integration tool for multidisciplinary research, which allows access, management, tailored pre-processing and visualization of datasets, crucial to foster research as a service to society. One application is the assessment and monitoring of renewable energy variability, such as wind or solar energy, at several time and space scales. We demonstrate the ability of the e-science platform for planning, monitoring and management of renewable energy, particularly offshore wind energy in the Euro-Atlantic region. Further we explore the automatization of processes using different domains and datasets, which facilitate further research in evaluating and understanding renewable energy variability. AcknowledgementsThis work is supported by Foundation for Science and Technology (FCT), Portugal, project UID/GEO/50019/2013 - Instituto Dom Luiz.

Vascular Anomalies.

PubMed

Taghinia, Amir H; Upton, Joseph

2018-06-12

Vascular anomalies encompass a wide variety of clinical conditions involving the vasculature. Over the past several decades, the terminology has changed as our understanding of these conditions has improved. A well-accepted classification scheme has evolved with constant additions, updates, and revisions. Imaging techniques have also advanced with greater resolution and a better understanding of the correlation between imaging, clinical behavior, and natural history. Meanwhile, the treatment of these conditions has also changed, with greater focus on minimally invasive techniques as opposed to radical surgery. Despite these changes, surgical intervention remains a high-value option for select patients. With greater understanding of the molecular basis of these diseases, medical treatment has improved especially in severe cases where options remain limited. A multidisciplinary approach to comprehensive patient care usually yields the best outcome and is strongly encouraged. Copyright © 2018 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Applying systematic review methods to studies of people's views: an example from public health research.

PubMed

Harden, Angela; Garcia, Jo; Oliver, Sandy; Rees, Rebecca; Shepherd, Jonathan; Brunton, Ginny; Oakley, Ann

2004-09-01

Methods for systematic reviews are well developed for trials, but not for non-experimental or qualitative research. This paper describes the methods developed for reviewing research on people's perspectives and experiences ("views" studies) alongside trials within a series of reviews on young people's mental health, physical activity, and healthy eating. Reports of views studies were difficult to locate; could not easily be classified as "qualitative" or "quantitative"; and often failed to meet seven basic methodological reporting standards used in a newly developed quality assessment tool. Synthesising views studies required the adaptation of qualitative analysis techniques. The benefits of bringing together views studies in a systematic way included gaining a greater breadth of perspectives and a deeper understanding of public health issues from the point of view of those targeted by interventions. A systematic approach also aided reflection on study methods that may distort, misrepresent, or fail to pick up people's views. This methodology is likely to create greater opportunities for people's own perspectives and experiences to inform policies to promote their health.

Applying systematic review methods to studies of people's views: an example from public health research

PubMed Central

Harden, A.; Garcia, J.; Oliver, S.; Rees, R.; Shepherd, J.; Brunton, G.; Oakley, A.

2004-01-01

Methods for systematic reviews are well developed for trials, but not for non-experimental or qualitative research. This paper describes the methods developed for reviewing research on people's perspectives and experiences ("views" studies) alongside trials within a series of reviews on young people's mental health, physical activity, and healthy eating. Reports of views studies were difficult to locate; could not easily be classified as "qualitative" or "quantitative"; and often failed to meet seven basic methodological reporting standards used in a newly developed quality assessment tool. Synthesising views studies required the adaptation of qualitative analysis techniques. The benefits of bringing together views studies in a systematic way included gaining a greater breadth of perspectives and a deeper understanding of public health issues from the point of view of those targeted by interventions. A systematic approach also aided reflection on study methods that may distort, misrepresent, or fail to pick up people's views. This methodology is likely to create greater opportunities for people's own perspectives and experiences to inform policies to promote their health. PMID:15310807

Food allergy diagnosis and therapy: where are we now?

PubMed Central

Syed, Aleena; Kohli, Arunima; Nadeau, Kari C

2014-01-01

Food allergy is a growing worldwide epidemic that adversely effects up to 10% of the population. Causes and risk factors remain unclear and diagnostic methods are imprecise. There is currently no accepted treatment for food allergy. Therefore, there is an imminent need for greater understanding of food allergies, revised diagnostics and development of safe, effective therapies. Oral immunotherapy provides a particularly promising avenue, but is still highly experimental and not ready for clinical use. PMID:23998729

Coevolving advances in animal flight and aerial robotics

PubMed Central

Lentink, David

2017-01-01

Our understanding of animal flight has inspired the design of new aerial robots with more effective flight capacities through the process of biomimetics and bioinspiration. The aerodynamic origin of the elevated performance of flying animals remains, however, poorly understood. In this themed issue, animal flight research and aerial robot development coalesce to offer a broader perspective on the current advances and future directions in these coevolving fields of research. Together, four reviews summarize and 14 reports contribute to our understanding of low Reynolds number flight. This area of applied aerodynamics research is challenging to dissect due to the complicated flow phenomena that include laminar–turbulent flow transition, laminar separation bubbles, delayed stall and nonlinear vortex dynamics. Our mechanistic understanding of low Reynolds number flight has perhaps been advanced most by the development of dynamically scaled robot models and new specialized wind tunnel facilities: in particular, the tiltable Lund flight tunnel for animal migration research and the recently developed AFAR hypobaric wind tunnel for high-altitude animal flight studies. These world-class facilities are now complemented with a specialized low Reynolds number wind tunnel for studying the effect of turbulence on animal and robot flight in much greater detail than previously possible. This is particular timely, because the study of flight in extremely laminar versus turbulent flow opens a new frontier in our understanding of animal flight. Advancing this new area will offer inspiration for developing more efficient high-altitude aerial robots and removes roadblocks for aerial robots operating in turbulent urban environments.

Understanding handpump sustainability: Determinants of rural water source functionality in the Greater Afram Plains region of Ghana.

PubMed

Fisher, Michael B; Shields, Katherine F; Chan, Terence U; Christenson, Elizabeth; Cronk, Ryan D; Leker, Hannah; Samani, Destina; Apoya, Patrick; Lutz, Alexandra; Bartram, Jamie

2015-10-01

Safe drinking water is critical to human health and development. In rural sub-Saharan Africa, most improved water sources are boreholes with handpumps; studies suggest that up to one third of these handpumps are nonfunctional at any given time. This work presents findings from a secondary analysis of cross-sectional data from 1509 water sources in 570 communities in the rural Greater Afram Plains (GAP) region of Ghana; one of the largest studies of its kind. 79.4% of enumerated water sources were functional when visited; in multivariable regressions, functionality depended on source age, management, tariff collection, the number of other sources in the community, and the district. A Bayesian network (BN) model developed using the same data set found strong dependencies of functionality on implementer, pump type, management, and the availability of tools, with synergistic effects from management determinants on functionality, increasing the likelihood of a source being functional from a baseline of 72% to more than 97% with optimal management and available tools. We suggest that functionality may be a dynamic equilibrium between regular breakdowns and repairs, with management a key determinant of repair rate. Management variables may interact synergistically in ways better captured by BN analysis than by logistic regressions. These qualitative findings may prove generalizable beyond the study area, and may offer new approaches to understanding and increasing handpump functionality and safe water access.

Predicting body appreciation in young women: An integrated model of positive body image.

PubMed

Andrew, Rachel; Tiggemann, Marika; Clark, Levina

2016-09-01

This study examined a range of predictors, based on previous theoretical models, of positive body image in young adult women. Participants were 266 women who completed an online questionnaire measuring body appreciation, activity participation, media consumption, perceived body acceptance by others, self-compassion, and autonomy. Potential mechanisms in predicting body appreciation assessed were self-objectification, social appearance comparison, and thin-ideal internalisation. Results indicated that greater perceived body acceptance by others and self-compassion, and lower appearance media consumption, self-objectification, social comparison, and thin-ideal internalisation were related to greater body appreciation. An integrated model showed that appearance media (negatively) and non-appearance media and self-compassion (positively) were associated with lower self-objectification, social comparison, and thin-ideal internalisation, which in turn related to greater body appreciation. Additionally, perceived body acceptance by others was directly associated with body appreciation. The results contribute to an understanding of potential pathways of positive body image development, thereby highlighting possible intervention targets. Copyright © 2016 Elsevier Ltd. All rights reserved.

Greater Platte River Basins - Science to sustain ecosystems and communities

USGS Publications Warehouse

Thormodsgard, June M.

2009-01-01

The Greater Platte River Basins (GPRB), located in the heartland of the United States, provides a collaborative opportunity for the U.S. Geological Survey (USGS) and its partners to understand the sustainability of natural and managed ecosystems under changing climate and resource requirements.The Greater Platte River Basins, an area of about 140,000 square miles, sustains thousands of acres of lakes and wetlands, which provide a staging and resting area for the North American Central Flyway. Part of the GPRB is within the U.S. Corn Belt, one of the most productive agricultural ecosystems on Earth. Changes in water and land use, changing patterns of snowmelt in the Rocky Mountains, drought, and increasing demands for irrigation have reduced flows in the Platte River. These changes raise questions about the sustainability of the region for both wildlife and agriculture.The USGS and partners are developing a science strategy that will help natural-resource managers address and balance the needs of this region.

Making message recipients "feel right": how nonverbal cues can increase persuasion.

PubMed

Cesario, Joseph; Higgins, E Tory

2008-05-01

Nonverbal cues are an inherent component of most persuasive appeals. We use regulatory-fit theory as a framework for understanding the effect of nonverbal cues on a message's effectiveness, and as a foundation for developing a new persuasion technique. We propose that when the nonverbal cues of a message source sustain the motivational orientation of the recipient, the recipient experiences regulatory fit and feels right, and that this experience influences the message's effectiveness. Experimental results support these predictions. Participants experiencing regulatory fit (promotion-focus participants viewing messages delivered in an eager nonverbal style, prevention-focus participants viewing messages delivered in a vigilant nonverbal style) had more positive attitudes toward a message's topic and greater intentions to behave in accordance with its recommendation than did participants experiencing nonfit. Feeling right was also greater for participants experiencing fit than for those experiencing nonfit and was associated with greater message effectiveness. Regulatory-fit theory provides a framework for making precise predictions about when and for whom a nonverbal cue will affect persuasion.

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

DOE PAGES

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

2017-03-29

A successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Furthermore, problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development ofmore » pregnancy related problems at the molecular level. Here, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.« less

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

Successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy relatedmore » problems at the molecular level. In this perspective, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.« less

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

A successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Furthermore, problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development ofmore » pregnancy related problems at the molecular level. Here, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.« less

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging.

PubMed

Burnum-Johnson, Kristin E; Baker, Erin S; Metz, Thomas O

2017-12-01

Successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. In this perspective, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes. Copyright © 2017 IFPA, Elsevier Ltd. Published by Elsevier Ltd.. All rights reserved.

Understanding Time-driven Activity-based Costing.

PubMed

Sharan, Alok D; Schroeder, Gregory D; West, Michael E; Vaccaro, Alexander R

2016-03-01

Transitioning to a value-based health care system will require providers to increasingly scrutinize their outcomes and costs. Although there has been a great deal of effort to understand outcomes, cost accounting in health care has been a greater challenge. Currently the cost accounting methods used by hospitals and providers are based off a fee-for-service system. As resources become increasingly scarce and the health care system attempts to understand which services provide the greatest value, it will be critically important to understand the true costs of delivering a service. An understanding of the true costs of a particular service will help providers make smarter decisions on how to allocate and utilize resources as well as determine which activities are nonvalue added. Achieving value will require providers to have a greater focus on accurate outcome data as well as better methods of cost accounting.

Immunotherapy of Cancer in 2012

PubMed Central

Kirkwood, John M.; Butterfield, Lisa H.; Tarhini, Ahmad A.; Zarour, Hassane; Kalinski, Pawel; Ferrone, Soldano

2012-01-01

The immunotherapy of cancer has made significant strides in the past few years due to improved understanding of the underlying principles of tumor biology and immunology. These principles have been critical in the development of immunotherapy in the laboratory and in the implementation of immunotherapy in the clinic. This improved understanding of immunotherapy, enhanced by increased insights into the mechanism of tumor immune response and its evasion by tumors, now permits manipulation of this interaction and elucidates the therapeutic role of immunity in cancer. Also important, this improved understanding of immunotherapy and the mechanisms underlying immunity in cancer has fueled an expanding array of new therapeutic agents for a variety of cancers. Pegylated interferon-α2b as an adjuvant therapy and ipilimumab as therapy for advanced disease, both of which were approved by the United States Food and Drug Administration for melanoma in March 2011, are 2 prime examples of how an increased understanding of the principles of tumor biology and immunology have been translated successfully from the laboratory to the clinical setting. Principles that guide the development and application of immunotherapy include antibodies, cytokines, vaccines, and cellular therapies. The identification and further elucidation of the role of immunotherapy in different tumor types, and the development of strategies for combining immunotherapy with cytotoxic and molecularly targeted agents for future multimodal therapy for cancer will enable even greater progress and ultimately lead to improved outcomes for patients receiving cancer immunotherapy. PMID:22576456

New Hydrologic Insights to Advance Geophysical Investigation of the Unsaturated Zone

NASA Astrophysics Data System (ADS)

Nimmo, J. R.; Perkins, K. S.

2015-12-01

Advances in hydrology require information from the unsaturated zone, especially for problems related to groundwater contamination, water-supply sustainability, and ecohydrology. Unsaturated-zone processes are notoriously difficult to quantify; soils and rocks are visually opaque, spatially variable in the extreme, and easily disturbed by instrument installation. Thus there is great value in noninvasive techniques that produce water-related data of high density in space and time. Methods based on resistivity and electromagnetic waves have already produced significant new understanding of percolation processes, root-zone water retention, influences of evapotranspiration on soil-water, and effects of preferential flow. Further developments are underway for such purposes as noninvasive application to greater depths, increased resolution, adaptation for lab-scale experiments, and calibration in heterogeneous media. Beyond these, however, there is need for a stronger marriage of hydrologic and geophysical knowledge and perspective. Possible means to greater and faster progress include: Apply the latest hydrologic understanding, both pore-scale and macroscopic, to the detection of preferential flow paths and their degree of activation. In the continuing advancement of hardware and techniques, draw creatively from developments in such fields as high-energy physics, medical imaging, astrogeology, high-tech semiconductors, and bioinstrumentation. Sidestep the imaging process where possible to measure essential properties and fluxes more directly. Pose questions that have a strong end-use character, like "how does storm intensity relate to aquifer recharge rate" rather than "what is the shape of the wetting front". The greatest advances in geophysical investigation of the unsaturated zone will come from methods informed by the latest understanding of unsaturated systems and processes, and aimed as directly as possible at the answers to important hydrologic questions.

Nutritional modulation of gut microbiota - the impact on metabolic disease pathophysiology.

PubMed

Ojeda, Patricia; Bobe, Alexandria; Dolan, Kyle; Leone, Vanessa; Martinez, Kristina

2016-02-01

The obesity epidemic afflicts over one third of the United States population. With few therapies available to combat obesity, a greater understanding of the systemic causes of this and other metabolic disorders is needed to develop new, effective treatments. The mammalian intestinal microbiota contributes to metabolic processes in the host. This review summarizes the research demonstrating the interplay of diet, intestinal microbiota and host metabolism. We detail the effects of diet-induced modifications in microbial activity and resultant impact on (1) sensory perception of macronutrients and total energy intake; (2) nutrient absorption, transport and storage; (3) liver and biliary function; (4) immune-mediated signaling related to adipose inflammation; and (5) circadian rhythm. We also discuss therapeutic strategies aimed to modify host-microbe interactions, including prebiotics, probiotics and postbiotics, as well as fecal microbiota transplantation. Elucidating the role of gut microbes in shaping metabolic homeostasis or dysregulation provides greater insight into disease development and a promising avenue for improved treatment of metabolic dysfunction. Copyright © 2015 Elsevier Inc. All rights reserved.

Understanding girls' enrollment at Louise's Farm School: A qualitative case study

NASA Astrophysics Data System (ADS)

Nowak, Ashley E. P.

This thesis presents a qualitative case study of enrollment and retention considerations at Louise's Farm School (LFS) in Palmer, Alaska, with a focus on how gender is performed in this domain. Interviews with 25 students, 12 parents, and 14 instructors revealed the enrollment decision-making process, identifying constraints to and enablers of girls' participation. Findings included three primary factors as greatly influencing girls' enrollment: (1) mothers' backgrounds; (2) mothers' knowledge of and the misperceptions regarding outcomes of LFS programing; and (3) girls' interest in LFS curriculum. Findings also exposed differences in mothers' and instructors' expectations for the educative development of girls and boys, suggesting that there is greater pressure on girls to perform academically while boys are expected to need greater space for physical expression.

Constructed vs. received graphical representations for learning about scientific controversy: Implications for learning and coaching

NASA Astrophysics Data System (ADS)

Cavalli-Sforza, Violetta Laura Maria

Students in science classes hardly ever study scientific controversy, especially in terms of the different types of arguments used to support and criticize theories and hypotheses. Yet, learning the reasons for scientific debate and scientific change is an important part of appreciating the nature of the scientific enterprise and communicating it to the non-scientific world. This dissertation explores the usefulness of graphical representations in teaching students about scientific arguments. Subjects participating in an extended experiment studied instructional materials and used the Belvedere graphical interface to analyze texts drawn from an actual scientific debate. In one experimental condition, subjects used a box-and-arrow representation whose primitive graphical elements had preassigned meanings tailored to the domain of instruction. In the other experimental condition, subjects could use the graphical elements as they wished, thereby creating their own representation. The development of a representation, by forcing a deeper analysis, can potentially yield a greater understanding of the domain under study. The results of the research suggest two conclusions. From the perspective of learning target concepts, asking subjects to develop their own representation may not hurt those subjects who gain a sufficient understanding of the possibilities of abstract representation. The risks are much greater for less able subjects because, if they develop a representation that is inadequate for expressing the target concepts, they will use those concepts less or not at all. From the perspective of coaching subjects as they diagram their analysis of texts, a predefined representation has significant advantages. If it is appropriately expressive for the task, it provides a common language and clearer shared meaning between the subject and the coach. It also enables the coach to understand subjects' analysis more easily, and to evaluate it more effectively against the coach's own model of the ideal analysis.

Cancer and the family: assessment, communication and brief interventions-the development of an educational programme for healthcare professionals when a parent has cancer.

PubMed

Grant, Lucy; Sangha, Amrit; Lister, Sara; Wiseman, Theresa

2016-12-01

This study developed and piloted an educational intervention to support healthcare professionals (HCPs) to provide supportive care for families when a parent has cancer. Programme development followed the Medical Research Council (MRC) framework, beginning with examination of theory and research, and consultation with experts. The programme content incorporated attachment theory, child development and family systems theory. It was piloted thrice with HCPs from a cancer centre. The evaluation involved a questionnaire, comprising open-ended questions, completed before and after the programme. Data from the questionnaire were analysed using framework analysis. 31 HCPs from varying disciplines participated. The programme was evaluated positively by participants. Before the programme, participants had significant concerns about their professional competence, which included: managing their own emotions; a perceived sensitivity around raising child and family matters with patients and a lack of specialist experience, skills and knowledge. After completing the programme, participants reported greater understanding and knowledge, increased confidence to approach patients about family matters, greater skill to initiate conversations and explore family concerns and guiding parent-child communication according to the child's level of understanding, and an increased engagement and resilience for caring for parents with cancer. Supporting HCPs to provide family-centred care is likely to reduce psychological difficulties in families where a parent has cancer. Further work is planned to disseminate the programme, evaluate the transfer of skills into practice, assess how HCPs manage the emotional demands of providing supportive care over time, and consider on-going professional support for HCPs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Associations between regional moisture gradient, tree species dominance, and downed wood abundance

NASA Astrophysics Data System (ADS)

Johnson, A. C.; Mills, J.

2007-12-01

Downed wood functions as a source of nurse logs, physical structure in streams, food, and carbon. Because downed wood is important in upland and aquatic habitats, an understanding of wood recruitment along a continuum from wet to dry landscapes is critical for both preservation of biodiversity and restoration of natural ecosystem structure and function. We assessed downed wood in public and private forests of Washington and Oregon by using a subset of the Forest Inventory and Analysis (FIA) database including 15,842 sampled conditions. Multivariate regression trees, ANOVA, and t-tests were used to discern environmental conditions most closely associated with abundance of woody debris. Of the 16 parameters included in the analysis, rainfall, forest ownership, number of damaged standing trees, and forest elevation were most indicative of woody debris abundance. The Hemlock/spruce Group, including hemlock, spruce, cedar, and white pine, most associated with wetter soils, had significantly more downed wood than 12 other forest groups. The Ponderosa Pine Group, indicative of drier sites with higher fire frequencies, included ponderosa pine, sugar pine, and incense cedar, and had significantly less downed wood volume. Overall, the amount of woody debris in either the Spruce/hemlock Group or the Ponderosa Pine Group did not change significantly as tree age increased from 5 to 350 years. Plots within the Hemlock/spruce with greater standing tree volume also had significantly greater downed wood volume. In contrast, greater downed wood volume was not associated with greater standing tree volume in the Ponderosa Pine Group. Knowledge of linkages among environmental variables and stand characteristics are useful in development of regional forest models aimed at understanding the effects of climate change and disturbance on forest succession.

Improved Management of Water and Natural Resources Requires Open, Cognizant, Adaptive Science and Policy

NASA Astrophysics Data System (ADS)

Glynn, P. D.; Voinov, A. A.; Shapiro, C. D.; Jenni, K. E.

2017-12-01

Water issues impact the availability and use of other natural resources as well as environmental conditions. In an increasingly populated hyper-connected world, water issues are increasingly "wicked problems": complex problems with high uncertainties and no independent observers. Water is essential to life, and life affects water quality and availability. Scientists, managers, decision-makers, and the greater public all have a stake in improving the management of water resources. In turn, they are part of the systems that they are studying, deciding on, affecting, or trying to improve. Governance of water issues requires greater accessibility, traceability, and accountability (ATA) in science and policy. Water-related studies and decision-making need transdisciplinary science, inclusive participatory processes, and consideration and acceptance of multiple perspectives. Biases, Beliefs, Heuristics, and Values (BBHV) shape much of our perceptions and knowledge, and inevitably, affect both science and policy. Understanding the role of BBHV is critical to (1) understanding individual and group judgments and choices, (2) recognizing potential differences between societal "wants" and societal "needs", and (3) identifying "winners" and "losers" of policy decisions. Societal acceptance of proposed policies and actions can be fostered by enhancing participatory processes and by providing greater ATA in science, in policy, and in development of the laws, rules, and traditions that constrain decision-making. An adaptive science-infused governance framework is proposed that seeks greater cognizance of the role of BBHV in shaping science and policy choices and decisions, and that also seeks "Open Traceable Accountable Policy" to complement "Open Science". We discuss the limitations of the governance that we suggest, as well as tools and approaches to help implementation.

Knowing the ABCs: A Comparative Effectiveness Study of Two Methods of Diabetes Education

PubMed Central

Naik, Aanand D.; Teal, Cayla R.; Rodriguez, Elisa; Haidet, Paul

2011-01-01

Objective To test an active-learning, empowerment approach to teaching patients about the “diabetes ABCs” (hemoglobin A1C, systolic blood pressure, and low density lipoprotein cholesterol). Methods 84 (97%) diabetic patients who participated in a randomized effectiveness trial of two clinic-based group educational methods and completed a post-intervention assessment. The empowerment arm participated in a group session that incorporated two educational innovations (a conceptual metaphor to foster understanding, and team-based learning methods to foster active learning). The traditional diabetes education arm received a didactic group session focused on self-management and educational materials about the diabetes ABCs. Participants in both arms received individual review of their current ABC values. Results A questionnaire evaluated knowledge, understanding, and recall of the diabetes ABCs was administered three months after enrollment in the study. At three months, participants in the empowerment group demonstrated greater understanding of the diabetes ABCs (P<.0001), greater knowledge of their own values (P<.0001), and greater knowledge of guideline-derived target goals for the ABCs compared with participants in the traditional arm (P<.0001). Conclusion An active-learning, empowerment-based approach applied to diabetes education can lead to greater understanding and knowledge retention. Practice Implications An empowerment approach to education can facilitate informed, activated patients and increase performance of self-management behaviors. PMID:21300516

Combining research approaches to advance our understanding of drug addiction.

PubMed

van den Bree, Marianne B M

2005-04-01

Drug addiction is a complex behavior, likely to be influenced by various genes, environmental factors, and gene-gene and gene-environment interactions. Various aspects of addiction are studied by different disciplines. Animal studies are increasing insight into brain regions and genes associated with addiction. Epidemiologic studies are establishing the factors increasing risk for initiation and continuation of substance use. Twin and adoption studies are increasing our understanding of the complex mechanisms involved in substance use, including comorbidity and gene environment interaction. Finally, molecular genetic studies in humans are starting to yield some converging findings. It is argued and illustrated with examples that greater awareness of progress in other disciplines can speed up our understanding of the complex processes involved in addiction. This should help our ability to identify who is at increased risk of becoming addicted and the development of prevention and intervention strategies targeted at an individual's specific needs.

Innovating undergraduate pathology education through public engagement.

PubMed

Mukundu Nagesh, Navin; Chiva Giurca, Bogdan; Lishman, Suzy

2018-05-01

The trends in modern undergraduate medical education focus on a patient-centred approach through problem-based learning over the traditional modular curriculum. Integrating pathology into this style of learning has resulted in the dilution of core scientific principles which may have contributed to reduced understanding and interest in the subject. We aim to innovate pathology education by utilising National Pathology Week which is organised by the Royal College of Pathologists to develop the public engagement model which empowers students to learn pathology by teaching the public. Through this model, we hope to generate a greater interest in pathology at both undergraduate and postgraduate stages of education. We obtained funding from the Royal College of Pathologists to organise National Pathology Week at Exeter Medical School and the Royal Devon & Exeter Hospital. We involved 125 undergraduate student volunteers from health-related courses. We designed a curriculum aiming to educate both students and public on current topics such as cancer screening programmes, antibiotic resistance, diagnosis of inflammatory bowel disease and the role of pathologists. We hosted 15 pathologists, biomedical scientists and microbiologists to engage with students, share experiences and offer an insight into their careers. Through this project, we interacted with over 500 members of the public and 150 school students. The medical student volunteers developed a range of skills including competent use of microscopes to visualise pathology slides, effective communication with lay audiences to teach pathology and understanding of the clinical application of pathology. We believe the public engagement model of teaching undergraduate students has the potential to develop a greater interest in pathology whilst benefitting the wider community.

Peromyscus as a model system for human hepatitis C: An opportunity to advance our understanding of a complex host parasite system.

PubMed

Vandegrift, Kurt J; Critchlow, Justin T; Kapoor, Amit; Friedman, David A; Hudson, Peter J

2017-01-01

Worldwide, there are 185 million people infected with hepatitis C virus and approximately 350,000 people die each year from hepatitis C associated liver diseases. Human hepatitis C research has been hampered by the lack of an appropriate in vivo model system. Most of the in vivo research has been conducted on chimpanzees, which is complicated by ethical concerns, small sample sizes, high costs, and genetic heterogeneity. The house mouse system has led to greater understanding of a wide variety of human pathogens, but it is unreasonable to expect Mus musculus to be a good model system for every human pathogen. Alternative animal models can be developed in these cases. Ferrets (influenza), cotton rats (human respiratory virus), and woodchucks (hepatitis B) are all alternative models that have led to a greater understanding of human pathogens. Rodent models are tractable, genetically amenable and inbred and outbred strains can provide homogeneity in results. Recently, a rodent homolog of hepatitis C was discovered and isolated from the liver of a Peromyscus maniculatus. This represents the first small mammal (mouse) model system for human hepatitis C and it offers great potential to contribute to our understanding and ultimately aid in our efforts to combat this serious public health concern. Peromyscus are available commercially and can be used to inform questions about the origin, transmission, persistence, pathology, and rational treatment of hepatitis C. Here, we provide a disease ecologist's overview of this new virus and some suggestions for useful future experiments. Copyright © 2016. Published by Elsevier Ltd.

Hierarchical population structure in greater sage-grouse provides insight into management boundary delineation

Treesearch

Todd B. Cross; David E. Naugle; John C. Carlson; Michael K. Schwartz

2016-01-01

Understanding population structure is important for guiding ongoing conservation and restoration efforts. The greater sage-grouse (Centrocercus urophasianus) is a species of concern distributed across 1.2 million km2 of western North America. We genotyped 1499 greater sagegrouse from 297 leks across Montana, North Dakota and South Dakota using a 15 locus...

Autoimmune encephalitis.

PubMed

Newman, M P; Blum, S; Wong, R C W; Scott, J G; Prain, K; Wilson, R J; Gillis, D

2016-02-01

Over the past decade, the clinical spectrum of autoimmune encephalitis has expanded with the emergence of several new clinicopathological entities. In particular, autoimmune encephalitis has recently been described in association with antibodies to surface receptors and ion channels on neurological tissues. Greater clinician awareness has resulted in autoimmune encephalitis being increasingly recognised in patients with unexplained neurological and psychiatric symptoms and signs. The clinical spectrum of presentations, as well as our understanding of disease mechanisms and treatment regimens, is rapidly developing. An understanding of these conditions is important to all subspecialties of Internal Medicine, including neurology and clinical immunology, psychiatry, intensive care and rehabilitation medicine. This review provides a contemporary overview of the aetiology, investigations and treatment of the most recently described autoimmune encephalitides. © 2016 Royal Australasian College of Physicians.

Quantum biology of the retina.

PubMed

Sia, Paul Ikgan; Luiten, André N; Stace, Thomas M; Wood, John Pm; Casson, Robert J

2014-08-01

The emerging field of quantum biology has led to a greater understanding of biological processes at the microscopic level. There is recent evidence to suggest that non-trivial quantum features such as entanglement, tunnelling and coherence have evolved in living systems. These quantum features are particularly evident in supersensitive light-harvesting systems such as in photosynthesis and photoreceptors. A biomimetic strategy utilizing biological quantum phenomena might allow new advances in the field of quantum engineering, particularly in quantum information systems. In addition, a better understanding of quantum biological features may lead to novel medical diagnostic and therapeutic developments. In the present review, we discuss the role of quantum physics in biological systems with an emphasis on the retina. © 2014 Royal Australian and New Zealand College of Ophthalmologists.

The affect of vision and compassion upon role factors in physician leadership.

PubMed

Quinn, Joann F

2015-01-01

The career path for many professionals is often into a leadership role, yet many professionals do not have the competencies or inclination to lead. This study explores physician leaders as a representative group of professionals. While there have been many efforts at understanding the characteristics of effective physician leaders, a greater understanding is needed on the nature of physician leadership. The largest healthcare organization for physician leaders in the United States was surveyed to gain a greater understanding of the nature of leadership. Partial Lease Squares (PLS) was used to analyze results from 677 online surveys to understand the causal relationship of role conflict and role endorsement to participation. The findings reveal the mediating influence that positivity exerts upon participation, and offers health care leaders an opportunity to increase understanding of the social identification process that leads a higher level of professional participation, which may increase effectiveness for physicians in leadership.

Developing Creative and Critical Thinkers

DTIC Science & Technology

2009-12-01

competitive advantage and long-term success. Strategic thinking meshes anticipated requirements with future organizational capabilities to ensure the organization wins in the future. Examples of failures in strategic thinking abound. They include the recent failures of U.S. auto companies to understand the key factors facing their industry. Of greater significance is our own failure of strategic thinking in the formulation and acceptance of the many pre-war assumptions about Iraq. The core elements of strategic thinking are the ability to think creatively and critically

Primary care--opportunities and threats. Developing professional knowledge: making primary care education and research more relevant.

PubMed Central

Pearson, P.; Jones, K.

1997-01-01

The trio of recent government white papers heralds a new world for primary care. Many changes in the education of future primary health care professionals and in the research ethos of the discipline will be needed to realise this vision. New skills and attitudes, not least in multidisciplinary working; lifelong learning; and greater understanding of and participation in primary care research will have to emerge from educational efforts in the next few years. PMID:9081008

Cultural Aspects of Secrecy in Global Economy

NASA Astrophysics Data System (ADS)

Serradell-Lopez, Enric; Cavaller, Victor

The main objective of this paper is to provide greater understanding of the nature of secrecy in firms. It presents an effort to develop some links between management of the secrecy and its relationship with culture. Using measures from Hofstede's work, we have linked some dimensions of national culture with CIS 3 UE survey database. The results show that some attributes of the culture as Masculinity and Uncertainty Avoidance have impact on the tendency of the firms for not to patent and maintain secrecy of their innovations.

Scale-Up: Improving Large Enrollment Physics Courses

NASA Astrophysics Data System (ADS)

Beichner, Robert

1999-11-01

The Student-Centered Activities for Large Enrollment University Physics (SCALE-UP) project is working to establish a learning environment that will promote increased conceptual understanding, improved problem-solving performance, and greater student satisfaction, while still maintaining class sizes of approximately 100. We are also addressing the new ABET engineering accreditation requirements for inquiry-based learning along with communication and team-oriented skills development. Results of studies of our latest classroom design, plans for future classroom space, and the current iteration of instructional materials will be discussed.

Gene Therapy Targeting Glaucoma: Where Are We?

PubMed Central

Liu, Xuyang; Rasmussen, Carol A.; Gabelt, B’Ann T.; Brandt, Curtis R.; Kaufman, Paul L.

2010-01-01

In a chronic disease such as glaucoma, a therapy that provides a long lasting local effect, with minimal systemic side effects, while circumventing the issue of patient compliance, is very attractive. The field of gene therapy is growing rapidly and ocular applications are expanding. Our understanding of the molecular pathogenesis of glaucoma is leading to greater specificity in ocular tissue targeting. Improvements in gene delivery techniques, refinement of vector construction methods, and development of better animal models combine to bring this potential therapy closer to reality. PMID:19539835

Understanding Adult Overweight and Obesity

MedlinePlus

... Step in the Right Direction Understanding Adult Overweight & Obesity View or Print All Sections Definition & Facts The terms “overweight” and “obesity” refer to body weight that is greater than ...

College Campus Community Readiness to Address Intimate Partner Violence Among LGBTQ+ Young Adults: A Conceptual and Empirical Examination.

PubMed

Edwards, Katie M; Littleton, Heather L; Sylaska, Kateryna M; Crossman, Annie L; Craig, Meghan

2016-09-01

This paper provides an overview of a conceptual model that integrates theories of social ecology, minority stress, and community readiness to better understand risk for and outcomes of intimate partner violence (IPV) among LGBTQ+ college students. Additionally, online survey data was collected from a sample of 202 LGBTQ+ students enrolled in 119 colleges across the United States to provide preliminary data on some aspects of the proposed model. Results suggested that students generally thought their campuses were low in readiness to address IPV; that is, students felt that their campuses could do more to address IPV and provide IPV services specific to LGBTQ+ college students. Perceptions of greater campus readiness to address IPV among LGBTQ+ college students was significantly and positively related to a more favorable LGBTQ+ campus climate and a greater sense of campus community. Additionally, IPV victims were more likely to perceive higher levels of campus community readiness than non-IPV victims. There was no association between IPV perpetration and perceptions of campus community readiness. Greater sense of community was marginally and inversely related to IPV victimization and perpetration. Sense of community and LGBTQ+ campus climate also varied to some extent as a function of region of the country and type of institution. Implications for further development and refinement of the conceptual model, as well as future research applying this model to better understand IPV among sexual minority students are discussed. © Society for Community Research and Action 2016.

Undergraduate medical students’ empathy: current perspectives

PubMed Central

Quince, Thelma; Thiemann, Pia; Benson, John; Hyde, Sarah

2016-01-01

Empathy is important to patient care. It enhances patients’ satisfaction, comfort, self-efficacy, and trust which in turn may facilitate better diagnosis, shared decision making, and therapy adherence. Empathetic doctors experience greater job satisfaction and psychological well-being. Understanding the development of empathy of tomorrow’s health care professionals is important. However, clinical empathy is poorly defined and difficult to measure, while ways to enhance it remain unclear. This review examines empathy among undergraduate medical students, focusing upon three main questions: How is empathy measured? This section discusses the problems of assessing empathy and outlines the utility of the Jefferson Scale of Empathy – Student Version and Davis’s Interpersonal Reactivity Index. Both have been used widely to assess medical students’ empathy. Does empathy change during undergraduate medical education? The trajectory of empathy during undergraduate medical education has been and continues to be debated. Potential reasons for contrasting results of studies are outlined. What factors may influence the development of empathy? Although the influence of sex is widely recognized, the impact of culture, psychological well-being, and aspects of undergraduate curricula are less well understood. This review identifies three interrelated issues for future research into undergraduate medical students’ empathy. First, the need for greater clarity of definition, recognizing that empathy is multidimensional. Second, the need to develop meaningful ways of measuring empathy which include its component dimensions and which are relevant to patients’ experiences. Medical education research has generally relied upon single, self-report instruments, which have utility across large populations but are limited. Finally, there is a need for greater methodological rigor in investigating the possible determinants of clinical empathy in medical education. Greater specificity of context and the incorporation of work from other disciplines may facilitate this. PMID:27536168

Effect of static foot posture on the dynamic stiffness of foot joints during walking.

PubMed

Sanchis-Sales, E; Sancho-Bru, J L; Roda-Sales, A; Pascual-Huerta, J

2018-05-01

The static foot posture has been related to the development of lower limb injuries. This study aimed to investigate the dynamic stiffness of foot joints during gait in the sagittal plane to understand the role of the static foot posture in the development of injuries. Seventy healthy adult male subjects with different static postures, assessed by the Foot Posture Index (FPI) (30 normal, 20 highly pronated and 20 highly supinated), were recruited. Kinematic and kinetic data were recorded using an optical motion capture system and a pressure platform, and dynamic stiffness at the different stages of the stance was calculated from the slopes of the linear regression on the flexion moment-angle curves. The effect of foot type on dynamic stiffness and on ranges of motion and moments was analysed using ANOVAs and post-hoc tests, and linear correlation between dynamic stiffness and FPI was also tested. Highly pronated feet showed a significantly smaller range of motion at the ankle and metatarsophalangeal joints and also a larger range of moments at the metatarsophalangeal joint than highly supinated feet. Dynamic stiffness during propulsion was significantly greater at all foot joints for highly pronated feet, with positive significant correlations with the squared FPI. Highly supinated feet showed greater dynamic stiffness than normal feet, although to a lesser extent. Highly pronated feet during normal gait experienced the greatest decrease in the dorsiflexor moments during propulsion, normal feet being the most balanced regarding work generated and absorbed. Extreme static foot postures show greater dynamic stiffness during propulsion and greater absorbed work, which increases the risk of developing injuries. The data presented may be used when designing orthotics or prostheses, and also when planning surgery that modifies joint stiffness. Copyright © 2018 Elsevier B.V. All rights reserved.

Introductory Biology Students’ Use of Enhanced Answer Keys and Reflection Questions to Engage in Metacognition and Enhance Understanding

PubMed Central

Sabel, Jaime L.; Dauer, Joseph T.; Forbes, Cory T.

2017-01-01

Providing feedback to students as they learn to integrate individual concepts into complex systems is an important way to help them to develop robust understanding, but it is challenging in large, undergraduate classes for instructors to provide feedback that is frequent and directed enough to help individual students. Various scaffolds can be used to help students engage in self-regulated learning and generate internal feedback to improve their learning. This study examined the use of enhanced answer keys with added reflection questions and instruction as scaffolds for engaging undergraduate students in self-regulated learning within an introductory biology course. Study findings show that both the enhanced answer keys and reflection questions helped students to engage in metacognition and develop greater understanding of biological concepts. Further, students who received additional instruction on the use of the scaffolds changed how they used them and, by the end of the semester, were using the scaffolds in significantly different ways and showed significantly higher learning gains than students who did not receive the instruction. These findings provide evidence for the benefit of designing scaffolds within biology courses that will support students in engaging in metacognition and enhancing their understanding of biological concepts. PMID:28645893

"Theory Becoming Alive": The Learning Transition Process of Newly Graduated Nurses in Canada.

PubMed

Nour, Violet; Williams, Anne M

2018-01-01

Background Newly graduated nurses often encounter a gap between theory and practice in clinical settings. Although this has been the focus of considerable research, little is known about the learning transition process. Purpose The purpose of this study was to explore the experiences of newly graduated nurses in acute healthcare settings within Canada. This study was conducted to gain a greater understanding of the experiences and challenges faced by graduates. Methods Grounded theory method was utilized with a sample of 14 registered nurses who were employed in acute-care settings. Data were collected using in-depth interviews. Constant comparative analysis was used to analyze data. Results Findings revealed a core category, "Theory Becoming Alive," and four supporting categories: Entry into Practice, Immersion, Committing, and Evolving. Theory Becoming Alive described the process of new graduate nurses' clinical learning experiences as well as the challenges that they encountered in clinical settings after graduating. Conclusions This research provides a greater understanding of learning process of new graduate nurses in Canada. It highlights the importance of providing supportive environments to assist new graduate nurses to develop confidence as independent registered nurses in clinical areas. Future research directions as well as supportive educational strategies are described.

Resilients, overcontrollers and undercontrollers: A systematic review of the utility of a personality typology method in understanding adult mental health problems.

PubMed

Bohane, Laura; Maguire, Nick; Richardson, Thomas

2017-11-01

The person-centred typological approach to personality makes the distinction between overcontrolled and undercontrolled personality types. This review systematically searched for research on the utility of these personality types in adult mental health. A total of 43 papers were included, which were divided broadly into cross-sectional studies, longitudinal studies and studies with clinical populations. Three personality types have been largely replicated in both normal and clinical populations: resilients, overcontrollers and undercontrollers. These types show utility in predicting long-term functioning and mental health, understanding heterogeneous personalities within clinical subgroups and have implications for treatment. Some disagreement on the number of personality types deemed replicable across samples and differing methodologies do exist, with some finding a dimensional approach to personality to have greater predictive utility. These personality types have been shown to be important in a number of mental health problems such as eating disorders, which may prove helpful in developing new psychological interventions. These studies point to the importance of overcontrolled personality types as well as undercontrolled in mental health. More research is needed with a greater range of clinical populations. Copyright © 2017 Elsevier Ltd. All rights reserved.

Novel therapeutic uses and formulations of botulinum neurotoxins: a patent review (2012 - 2014).

PubMed

Kane, Christopher D; Nuss, Jonathan E; Bavari, Sina

2015-06-01

Botulinum neurotoxins (BoNTs) are among the most toxic of known biological molecules and function as acetylcholine release inhibitors and neuromuscular blocking agents. Paradoxically, these properties also make them valuable therapeutic agents for the treatment of movement disorders, urological conditions and hypersecretory disorders. Greater understanding of their molecular mechanism of action and advances in protein engineering has led to significant efforts to improve and expand their function with a view towards broadening their therapeutic potential. Searches of Espacenet and Google Patent have revealed a number of patents related to BoNTs. This review will focus on novel therapeutic uses and formulations disclosed during 2012 - 2014. The seven patents discussed will include nanoformulations of FDA-approved BoNTs, additional BoNT subtypes and novel BoNT variants and chimeras created through protein engineering. Supporting patents and related publications are also briefly discussed. The clinical and commercial success of BoNTs has prompted investigation into novel BoNTs or BoNT-mediated chimeras with promising in vitro results. Distinct strategies including the use of nanoformulations and targeted delivery have been implemented to identify new indication and improved functionality. Greater understanding of their systemic exposure, efficacy and safety profiles will be required for further development.

Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons

PubMed Central

Shum, Carole; Macedo, Sara C.; Warre-Cornish, Katherine; Cocks, Graham; Price, Jack; Srivastava, Deepak P.

2015-01-01

This article is part of a Special Issue “Estradiol and Cognition”. Over recent years tremendous progress has been made towards understanding the molecular and cellular mechanism by which estrogens exert enhancing effects on cognition, and how they act as a neuroprotective or neurotrophic agent in disease. Currently, much of this work has been carried out in animal models with only a limited number of studies using native human tissue or cells. Recent advances in stem cell technology now make it possible to reprogram somatic cells from humans into induced pluripotent stem cells (iPSCs), which can subsequently be differentiated into neurons of specific lineages. Importantly, the reprogramming of cells allows for the generation of iPSCs that retain the genetic “makeup” of the donor. Therefore, it is possible to generate iPSC-derived neurons from patients diagnosed with specific diseases, that harbor the complex genetic background associated with the disorder. Here, we review the iPSC technology and how it's currently being used to model neural development and neurological diseases. Furthermore, we explore whether this cellular system could be used to understand the role of estrogens in human neurons, and present preliminary data in support of this. We further suggest that the use of iPSC technology offers a novel system to not only further understand estrogens' effects in human cells, but also to investigate the mechanism by which estrogens are beneficial in disease. Developing a greater understanding of these mechanisms in native human cells will also aid in the development of safer and more effective estrogen-based therapeutics. PMID:26143621

Development of Bone Remodeling Model for Spaceflight Bone Physiology Analysis

NASA Technical Reports Server (NTRS)

Pennline, James A.; Werner, Christopher R.; Lewandowski, Beth; Thompson, Bill; Sibonga, Jean; Mulugeta, Lealem

2015-01-01

Current spaceflight exercise countermeasures do not eliminate bone loss. Astronauts lose bone mass at a rate of 1-2% a month (Lang et al. 2004, Buckey 2006, LeBlanc et al. 2007). This may lead to early onset osteoporosis and place the astronauts at greater risk of fracture later in their lives. NASA seeks to improve understanding of the mechanisms of bone remodeling and demineralization in 1g in order to appropriately quantify long term risks to astronauts and improve countermeasures. NASA's Digital Astronaut Project (DAP) is working with NASA's bone discipline to develop a validated computational model to augment research efforts aimed at achieving this goal.

Cognitive neuroscience: the troubled marriage of cognitive science and neuroscience.

PubMed

Cooper, Richard P; Shallice, Tim

2010-07-01

We discuss the development of cognitive neuroscience in terms of the tension between the greater sophistication in cognitive concepts and methods of the cognitive sciences and the increasing power of more standard biological approaches to understanding brain structure and function. There have been major technological developments in brain imaging and advances in simulation, but there have also been shifts in emphasis, with topics such as thinking, consciousness, and social cognition becoming fashionable within the brain sciences. The discipline has great promise in terms of applications to mental health and education, provided it does not abandon the cognitive perspective and succumb to reductionism. Copyright © 2010 Cognitive Science Society, Inc.

Mars together and FIRE and ICE: Report of the joint US/Russian technical working groups

NASA Technical Reports Server (NTRS)

1994-01-01

The Cold War's end opened an opportunity for greater cooperation in planetary exploration for the United States and Russia. Two study groups were formed, Mars Together and FIRE and ICE. The Mars Together team developed a concept for a flight in 1998 that merged one U.S. Mars Surveyor 98 mission with the former Russian Mars 96 mission to further understanding of the Mars surface and atmosphere. The FIRE and ICE team developed concepts for a dual-spacecraft mission to the solar corona and for a mission to Pluto. The missions, scientific potential, and open issues are described.

Age differences in IDA savings outcomes: findings from the American Dream Demonstration.

PubMed

Putnam, Michelle; Sherraden, Michael; Zhang, Lin; Morrow-Howell, Nancy

2008-01-01

This study aims to develop a greater understanding of age differences in savings outcomes within Individual Development Accounts (IDAs). Participant data from the American Dream Demonstration (ADD) are examined for age differences in accumulated net deposits, average monthly net deposits, and deposit frequency. ADDprogram data are examined for savings match rates, monthly savings targets, direct deposit, and hours of financial education offered. Results indicate that, on average, older IDA participants have better savings outcomes than younger participants. Findings from this study suggest that impoverished middleaged and older adults can save if provided an opportunity and incentives. However, success will depend on the characteristics of the programs.

Mars together and FIRE and ICE: Report of the joint US/Russian technical working groups

NASA Astrophysics Data System (ADS)

1994-10-01

The Cold War's end opened an opportunity for greater cooperation in planetary exploration for the United States and Russia. Two study groups were formed, Mars Together and FIRE and ICE. The Mars Together team developed a concept for a flight in 1998 that merged one U.S. Mars Surveyor 98 mission with the former Russian Mars 96 mission to further understanding of the Mars surface and atmosphere. The FIRE and ICE team developed concepts for a dual-spacecraft mission to the solar corona and for a mission to Pluto. The missions, scientific potential, and open issues are described.

Mechanistic understanding of the effects of natural gas development on sagebrush-obligate songbird nest predation rates

NASA Astrophysics Data System (ADS)

Hethcoat, Matthew G.

Natural gas development has rapidly increased within sagebrush ( Artemisia spp.) dominated landscapes of the Intermountain West. Prior research in the Upper Green River Basin, Wyoming demonstrated increased nest predation of sagebrush-obligate songbirds with higher densities of natural gas wells. To better understand the mechanisms underlying this pattern, I assessed this commonly used index of oil and gas development intensity (well density) for estimating habitat transformation and predicting nest survival for songbirds breeding in energy fields during 2008- 2009 and 2011-2012. We calculated landscape metrics (habitat loss, amount of edge, patch shape complexity, and mean patch size) to identify the aspect of landscape transformation most captured by well density. Well density was most positively associated with the amount of habitat loss within 1 square kilometer. Daily nest survival was relatively invariant with respect to well density for all three species. In contrast, nest survival rates of all three species consistently decreased with increased surrounding habitat loss due to energy development. Thus, although well density and habitat loss were strongly correlated, at times they provided contrasting estimates of nest survival probability. Additionally, we tested the hypothesis that surrounding habitat loss influenced local nest predation rates via increased predator activity. During 2011- 2012, we surveyed predators and monitored songbird nests at twelve sites in western Wyoming. Nine species, representing four mammalian and three avian families, were video-recorded depredating eggs and nestlings. Approximately 75% of depredation events were caused by rodents. While chipmunk (Tamias minimus) detections were negatively associated with increased habitat loss, mice (Peromyscus maniculatus and Reithrodontomys megalotis) and ground squirrels (Ictidomys tridecemlineatus and Urocitellus armatus) increased with greater surrounding habitat loss. Consistent with our predictions, nest survival significantly declined at study locations with greater predator activity for Brewer's Sparrows (Spizella breweri) and Sagebrush Sparrows (Artemisiospiza nevadensis ). Our work is among the few studies which have identified mechanisms underlying increased nest predation rates, linking predation patterns, nest predators, and human-induced habitat alteration. Our results demonstrate the importance of simultaneous study of habitat change, predators, and prey in understanding the mechanisms by which evolved predator-prey relationships can be affected by human-induced rapid environmental change.

Cognitive control and reward/loss processing in Internet gaming disorder: Results from a comparison with recreational Internet game-users.

PubMed

Dong, G; Li, H; Wang, L; Potenza, M N

2017-07-01

Although playing of Internet games may lead to Internet gaming disorder (IGD), most game-users do not develop problems and only a relatively small subset experiences IGD. Game playing may have positive health associations, whereas IGD has been repeatedly associated with negative health measures, and it is thus important to understand differences between individuals with IGD, recreational (non-problematic) game use (RGU) and non-/low-frequency game use (NLFGU). Individuals with IGD have shown differences in neural activations from non-gamers, yet few studies have examined neural differences between individuals with IGD, RGU and NLFGU. Eighteen individuals with IGD, 21 with RGU and 19 with NFLGU performed a color-word Stroop task and a guessing task assessing reward/loss processing. Behavioral and functional imaging data were collected and compared between groups. RGU and NLFGU subjects showed lower Stroop effects as compared with those with IGD. RGU subjects as compared to those with IGD demonstrated less frontal cortical activation brain activation during Stroop performance. During the guessing task, RGU subjects showed greater cortico-striatal activations than IGD subjects during processing of winning outcomes and greater frontal brain during processing of losing outcomes. Findings suggest that RGU as compared with IGD subjects show greater executive control and greater activations of brain regions implicated in motivational processes during reward processing and greater cortical activations during loss processing. These findings suggest neural and behavioral features distinguishing RGU from IGD and mechanisms by which RGU may be motivated to play online games frequently yet avoid developing IGD. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Forward Monte Carlo Computations of Polarized Microwave Radiation

NASA Technical Reports Server (NTRS)

Battaglia, A.; Kummerow, C.

2000-01-01

Microwave radiative transfer computations continue to acquire greater importance as the emphasis in remote sensing shifts towards the understanding of microphysical properties of clouds and with these to better understand the non linear relation between rainfall rates and satellite-observed radiance. A first step toward realistic radiative simulations has been the introduction of techniques capable of treating 3-dimensional geometry being generated by ever more sophisticated cloud resolving models. To date, a series of numerical codes have been developed to treat spherical and randomly oriented axisymmetric particles. Backward and backward-forward Monte Carlo methods are, indeed, efficient in this field. These methods, however, cannot deal properly with oriented particles, which seem to play an important role in polarization signatures over stratiform precipitation. Moreover, beyond the polarization channel, the next generation of fully polarimetric radiometers challenges us to better understand the behavior of the last two Stokes parameters as well. In order to solve the vector radiative transfer equation, one-dimensional numerical models have been developed, These codes, unfortunately, consider the atmosphere as horizontally homogeneous with horizontally infinite plane parallel layers. The next development step for microwave radiative transfer codes must be fully polarized 3-D methods. Recently a 3-D polarized radiative transfer model based on the discrete ordinate method was presented. A forward MC code was developed that treats oriented nonspherical hydrometeors, but only for plane-parallel situations.

An enquiry of 'Every3Days' a drama-based workshop developing professional collaboration for women experiencing domestic violence during pregnancy in the South East of England.

PubMed

Baird, Kathleen; Salmon, Debra

2012-12-01

this exploratory work examined and assessed the experiences of participants (n=90) using an interactive drama workshop to facilitate the planning and understanding of multiagency working around domestic violence during pregnancy. a descriptive research design was utilised to collect data from field observations, participant reflective feedback sheets and semi-structured telephone interviews. participants invited to the workshop originated from a wide range of backgrounds including health and social care, criminal justice and the third sector. All participants were invited to complete the reflective feedback evaluation form. To enhance the comprehensiveness of the enquiry, semi-structured interviews were also conducted with 10 of the participants. shared themes emerging from the data analysis included improved awareness of the consequences of domestic violence; greater understanding of multiple professional roles including the policy context and enhanced skill development. However, participants questioned the extent to which this approach impacted upon longer term practice and policy development. by centring attention on the emic perspective of women themselves, the drama approach developed professional's awareness, relationships, understanding and skills. Nevertheless, drama can be an expensive education tool. It is therefore essential that further research explores the longer term impacts on practice and outcomes for women that include cost-benefit analysis. Copyright © 2011 Elsevier Ltd. All rights reserved.

Linking children's neuropsychological processing of emotion with their knowledge of emotion expression regulation.

PubMed

Watling, Dawn; Bourne, Victoria J

2007-09-01

Understanding of emotions has been shown to develop between the ages of 4 and 10 years; however, individual differences exist in this development. While previous research has typically examined these differences in terms of developmental and/or social factors, little research has considered the possible impact of neuropsychological development on the behavioural understanding of emotions. Emotion processing tends to be lateralised to the right hemisphere of the brain in adults, yet this pattern is not as evident in children until around the age of 10 years. In this study 136 children between 5 and 10 years were given both behavioural and neuropsychological tests of emotion processing. The behavioural task examined expression regulation knowledge (ERK) for prosocial and self-presentational hypothetical interactions. The chimeric faces test was given as a measure of lateralisation for processing positive facial emotion. An interaction between age and lateralisation for emotion processing was predictive of children's ERK for only the self-presentational interactions. The relationships between children's ERK and lateralisation for emotion processing changes across the three age groups, emerging as a positive relationship in the 10-year-olds. The 10-years-olds who were more lateralised to the right hemisphere for emotion processing tended to show greater understanding of the need for regulating negative emotions during interactions that would have a self-presentational motivation. This finding suggests an association between the behavioural and neuropsychological development of emotion processing.

100 years of training and development research: What we know and where we should go.

PubMed

Bell, Bradford S; Tannenbaum, Scott I; Ford, J Kevin; Noe, Raymond A; Kraiger, Kurt

2017-03-01

Training and development research has a long tradition within applied psychology dating back to the early 1900s. Over the years, not only has interest in the topic grown but there have been dramatic changes in both the science and practice of training and development. In the current article, we examine the evolution of training and development research using articles published in the Journal of Applied Psychology ( JAP ) as a primary lens to analyze what we have learned and to identify where future research is needed. We begin by reviewing the timeline of training and development research in JAP from 1918 to the present in order to elucidate the critical trends and advances that define each decade. These trends include the emergence of more theory-driven training research, greater consideration of the role of the trainee and training context, examination of learning that occurs outside the classroom, and understanding training's impact across different levels of analysis. We then examine in greater detail the evolution of 4 key research themes: training criteria, trainee characteristics, training design and delivery, and the training context. In each area, we describe how the focus of research has shifted over time and highlight important developments. We conclude by offering several ideas for future training and development research. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

An Interdisciplinary Approach for Understanding Artworks: The Role of Music in Visual Arts Education

ERIC Educational Resources Information Center

Pavlou, Victoria; Athansiou, Georgina

2014-01-01

In a world that is becoming increasingly more visual, there is a greater need to educate children to better understand images. A school subject that deals directly with image understanding is visual arts. This article discusses an interdisciplinary approach to promote art understanding, within a multimodal environment that combines art and music.…

Structure-Property Relationships in Amorphous Transparent Conducting Oxides

NASA Astrophysics Data System (ADS)

Moffitt, Stephanie Lucille

Over the last 20 years a new field of amorphous transparent conducting oxides (a-TCOs) has developed. The amorphous nature of these films makes them well suited for large area applications. In addition, a-TCOs can be made at low temperatures and through solution processing methods. These assets provide promising opportunities to improve applications such as solar cells and back-lit displays where traditional crystalline TCOs are used. In addition, it opens the door for new technological applications including the possibility for transparent, flexible electronics. Despite the recent growth in this field, fundamental understanding of the true nature of conductivity and the amorphous structure in this materials system is still progressing. To develop a greater understanding of a-TCOs, structure-property relationships were developed in the a-IGO and a-IZO systems. From the combination of element-specific local structure studies and liquid quench molecular dynamics simulations it is clear that a degree of structure remains in a-TCOs. By understanding this structure, the effect of gallium on thermal stability, carrier concentration and carrier mobility is understood. The source of charge carriers in a-IZO is identified as oxygen vacancies through the application of in situ Brouwer analysis. The continued development of the Brouwer analysis technique for use in amorphous oxides adds to the available methods for studying defects in amorphous systems. Finally, the foundational knowledge gained from the in-depth study of a-IGO was extended to understand the role of combustion processing and pulsed laser deposition as growth methods for transistors based on a-IGO.

Proximate effects of temperature versus evolved intrinsic constraints for embryonic development times among temperate and tropical songbirds

USGS Publications Warehouse

Ton, Riccardo; Martin, Thomas E.

2017-01-01

The relative importance of intrinsic constraints imposed by evolved physiological trade-offs versus the proximate effects of temperature for interspecific variation in embryonic development time remains unclear. Understanding this distinction is important because slow development due to evolved trade-offs can yield phenotypic benefits, whereas slow development from low temperature can yield costs. We experimentally increased embryonic temperature in free-living tropical and north temperate songbird species to test these alternatives. Warmer temperatures consistently shortened development time without costs to embryo mass or metabolism. However, proximate effects of temperature played an increasingly stronger role than intrinsic constraints for development time among species with colder natural incubation temperatures. Long development times of tropical birds have been thought to primarily reflect evolved physiological trade-offs that facilitate their greater longevity. In contrast, our results indicate a much stronger role of temperature in embryonic development time than currently thought.

Patient predictors of colposcopy comprehension of consent among English- and Spanish-speaking women.

PubMed

Krankl, Julia Tatum; Shaykevich, Shimon; Lipsitz, Stuart; Lehmann, Lisa Soleymani

2011-01-01

patients with limited English proficiency may be at increased risk for diminished understanding of clinical procedures. This study sought to assess patient predictors of comprehension of colposcopy information during informed consent and to assess differences in understanding between English and Spanish speakers. between June and August 2007, English- and Spanish-speaking colposcopy patients at two Boston hospitals were surveyed to assess their understanding of the purpose, risks, benefits, alternatives, and nature of colposcopy. Patient demographic information was collected. there were 183 women who consented to participate in the study. We obtained complete data on 111 English speakers and 38 Spanish speakers. English speakers were more likely to have a higher education, greater household income, and private insurance. Subjects correctly answered an average of 7.91 ± 2.16 (72%) of 11 colposcopy survey questions. English speakers answered more questions correctly than Spanish speakers (8.50 ± 1.92 [77%] vs 6.21 ± 1.93 [56%]; p < .001). Using linear regression to adjust for confounding variables, we found that language was not significantly associated with greater understanding (p = .46). Rather, education was the most significant predictor of colposcopy knowledge (p < .001). many colposcopy patients did not understand the procedure well enough to give informed consent. The observed differences in colposcopy comprehension based on language were a proxy for differences in education. Education, not language, predicted subjects' understanding of colposcopy. These results demonstrate the need for greater attention to patients' educational background to ensure adequate understanding of clinical information. 2011 Jacobs Institute of Women's Health. Published by Elsevier Inc.

Putting patients first: a novel patient-centered model for medical enterprise success.

PubMed

Dhawan, Naveen

2014-01-01

This article introduces a new way of viewing patient-customers. It encourages a greater emphasis on patients' needs and the importance of considering dimensions of the patient experience to better serve them. It also draws from examples in the general business world as they can be applied to medical enterprises. The author introduces a model that directs all business activities toward the end consumer with an underlying guidance by patient needs. A business is advised to understand its customer, design a patient-directed vision, and focus on creating a unique customer experience. The article delineates key action items for physicians and administrators that will allow them to better meet their patient-customers' needs and develop loyalty. By practicing a patient-centered approach and following these guidelines, one may ensure greater success of the medical enterprise.

Development of multifunctional materials exhibiting distributed sensing and actuation inspired by fish

NASA Astrophysics Data System (ADS)

Philen, Michael

2011-04-01

This manuscript is an overview of the research that is currently being performed as part of a 2009 NSF Office of Emerging Frontiers in Research and Innnovation (EFRI) grant on BioSensing and BioActuation (BSBA). The objectives of this multi-university collaborative research are to achieve a greater understanding of the hierarchical organization and structure of the sensory, muscular, and control systems of fish, and to develop advanced biologically-inspired material systems having distributed sensing, actuation, and intelligent control. New experimental apparatus have been developed for performing experiments involving live fish and robotic devices, and new bio-inspired haircell sensors and artificial muscles are being developed using carbonaceous nanomaterials, bio-derived molecules, and composite technology. Results demonstrating flow sensing and actuation are presented.

Improving the readability and processability of a pediatric informed consent document: effects on parents' understanding.

PubMed

Tait, Alan R; Voepel-Lewis, Terri; Malviya, Shobha; Philipson, Sandra J

2005-04-01

To examine whether a consent document modified to conform with the federal guidelines for readability and processability would result in greater parental understanding compared with a standard form. Randomized clinical study. The preoperative waiting area of a larger tertiary care children's hospital. A total of 305 parents of children scheduled for minor elective surgical procedures. Parents were randomized to receive information about a clinical study in 1 of 4 ways: (1) standard consent form alone, (2) standard consent form with verbal disclosure, (3) modified form alone (standard form modified to meet the federal guidelines for readability and processability), and (4) modified form with verbal disclosure. Parents were interviewed to determine their understanding of 11 elements of consent, including study purpose, protocol, risks, benefits to child (direct), benefit to others (indirect), freedom to withdraw, alternatives, duration of study, voluntariness, confidentiality, and whom to contact. Their responses were scored by 2 independent assessors. Understanding of the protocol, study duration, risks, and direct benefits, together with overall understanding, was greater among parents who received the modified form (P<.001). Additionally, parents reported that the modified form had greater clarity (P = .009) and improved layout compared with the standard form (P<.001). When parents were shown both forms, 81.2% preferred the modified version. Results suggest that a consent form written according to federal guidelines for readability and processability can improve parent understanding and thus will be important in enhancing the informed consent process.

The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children

PubMed Central

Jasińska, Kaja K.; Molfese, Peter J.; Kornilov, Sergey A.; Mencl, W. Einar; Frost, Stephen J.; Lee, Maria; Pugh, Kenneth R.; Grigorenko, Elena L.; Landi, Nicole

2016-01-01

Understanding how genes impact the brain’s functional activation for learning and cognition during development remains limited. We asked whether a common genetic variant in the BDNF gene (the Val66Met polymorphism) modulates neural activation in the young brain during a critical period for the emergence and maturation of the neural circuitry for reading. In animal models, the bdnf variation has been shown to be associated with the structure and function of the developing brain and in humans it has been associated with multiple aspects of cognition, particularly memory, which are relevant for the development of skilled reading. Yet, little is known about the impact of the Val66Met polymorphism on functional brain activation in development, either in animal models or in humans. Here, we examined whether the BDNF Val66Met polymorphism (dbSNP rs6265) is associated with children’s (age 6–10) neural activation patterns during a reading task (n = 81) using functional magnetic resonance imaging (fMRI), genotyping, and standardized behavioral assessments of cognitive and reading development. Children homozygous for the Val allele at the SNP rs6265 of the BDNF gene outperformed Met allele carriers on reading comprehension and phonological memory, tasks that have a strong memory component. Consistent with these behavioral findings, Met allele carriers showed greater activation in reading–related brain regions including the fusiform gyrus, the left inferior frontal gyrus and left superior temporal gyrus as well as greater activation in the hippocampus during a word and pseudoword reading task. Increased engagement of memory and spoken language regions for Met allele carriers relative to Val/Val homozygotes during reading suggests that Met carriers have to exert greater effort required to retrieve phonological codes. PMID:27551971

The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children.

PubMed

Jasińska, Kaja K; Molfese, Peter J; Kornilov, Sergey A; Mencl, W Einar; Frost, Stephen J; Lee, Maria; Pugh, Kenneth R; Grigorenko, Elena L; Landi, Nicole

2016-01-01

Understanding how genes impact the brain's functional activation for learning and cognition during development remains limited. We asked whether a common genetic variant in the BDNF gene (the Val66Met polymorphism) modulates neural activation in the young brain during a critical period for the emergence and maturation of the neural circuitry for reading. In animal models, the bdnf variation has been shown to be associated with the structure and function of the developing brain and in humans it has been associated with multiple aspects of cognition, particularly memory, which are relevant for the development of skilled reading. Yet, little is known about the impact of the Val66Met polymorphism on functional brain activation in development, either in animal models or in humans. Here, we examined whether the BDNF Val66Met polymorphism (dbSNP rs6265) is associated with children's (age 6-10) neural activation patterns during a reading task (n = 81) using functional magnetic resonance imaging (fMRI), genotyping, and standardized behavioral assessments of cognitive and reading development. Children homozygous for the Val allele at the SNP rs6265 of the BDNF gene outperformed Met allele carriers on reading comprehension and phonological memory, tasks that have a strong memory component. Consistent with these behavioral findings, Met allele carriers showed greater activation in reading-related brain regions including the fusiform gyrus, the left inferior frontal gyrus and left superior temporal gyrus as well as greater activation in the hippocampus during a word and pseudoword reading task. Increased engagement of memory and spoken language regions for Met allele carriers relative to Val/Val homozygotes during reading suggests that Met carriers have to exert greater effort required to retrieve phonological codes.

An analysis of hospital capital planning and financing in three European countries: Using the principal-agent approach to identify the potential for economic problems.

PubMed

Thompson, Ceri R; McKee, Martin

2011-02-01

To explore differences in national approaches to hospital capital planning and financing in three European countries and to understand the roles and positions of the actors involved. Case studies of major new hospital developments were undertaken in each of the study countries (France, Sweden and England), based on a review of documents related to each development and the national framework within which they took place, as well as interviews with key informants. The principal-agent model was used, focusing on identification of differing utilities and information asymmetries. There are substantial differences between countries, for example in relation to the role of the hospital in its own redevelopment, the organisational distance between actors, the institutional level at which decision rights for major investments are exercised, and how principals control the agents. These differences have implications for the processes involved and the nature of economic and health care problems that can arise. There is evidence of, and opportunity for economic problems in all systems but these seems to be greater in France and England where the hospital leads the process, where there is limited involvement by the regional bodies, and informational differences appear greater. We conclude that hospital planning processes should be informed by an explicit understanding of the powerful groups involved and their divergent preferences and utilities. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Centres for Leadership: a strategy for academic integration.

PubMed

King, Gillian; Parker, Kathryn; Peacocke, Sean; Curran, C J; McPherson, Amy C; Chau, Tom; Widgett, Elaine; Fehlings, Darcy; Milo-Manson, Golda

2017-05-15

Purpose The purpose of this paper is to describe how an Academic Health Science Centre, providing pediatric rehabilitation services, research, and education, developed a Centres for Leadership (CfL) initiative to integrate its academic functions and embrace the goal of being a learning organization. Design/methodology/approach Historical documents, tracked output information, and staff members' insights were used to describe the ten-year evolution of the initiative, its benefits, and transformational learnings for the organization. Findings The evolutions concerned development of a series of CfLs, and changes over time in leadership and management structure, as well as in operations and targeted activities. Benefits included enhanced clinician engagement in research, practice-based research, and impacts on clinical practice. Transformational learnings concerned the importance of supporting stakeholder engagement, fostering a spirit of inquiry, and fostering leaderful practice. These learnings contributed to three related emergent outcomes reflecting "way stations" on the journey to enhanced evidence-informed decision making and clinical excellence: enhancements in authentic partnerships, greater innovation capacity, and greater understanding and actualization of leadership values. Practical implications Practical information is provided for other organizations interested in understanding how this initiative evolved, its tangible value, and its wider benefits for organizational collaboration, innovation, and leadership values. Challenges encountered and main messages for other organizations are also considered. Originality/value A strategy map is used to present the structures, processes, and outcomes arising from the initiative, with the goal of informing the operations of other organizations desiring to be learning organizations.

Understanding handpump sustainability: Determinants of rural water source functionality in the Greater Afram Plains region of Ghana†

PubMed Central

Shields, Katherine F.; Chan, Terence U.; Christenson, Elizabeth; Cronk, Ryan D.; Leker, Hannah; Samani, Destina; Apoya, Patrick; Lutz, Alexandra

2015-01-01

Abstract Safe drinking water is critical to human health and development. In rural sub‐Saharan Africa, most improved water sources are boreholes with handpumps; studies suggest that up to one third of these handpumps are nonfunctional at any given time. This work presents findings from a secondary analysis of cross‐sectional data from 1509 water sources in 570 communities in the rural Greater Afram Plains (GAP) region of Ghana; one of the largest studies of its kind. 79.4% of enumerated water sources were functional when visited; in multivariable regressions, functionality depended on source age, management, tariff collection, the number of other sources in the community, and the district. A Bayesian network (BN) model developed using the same data set found strong dependencies of functionality on implementer, pump type, management, and the availability of tools, with synergistic effects from management determinants on functionality, increasing the likelihood of a source being functional from a baseline of 72% to more than 97% with optimal management and available tools. We suggest that functionality may be a dynamic equilibrium between regular breakdowns and repairs, with management a key determinant of repair rate. Management variables may interact synergistically in ways better captured by BN analysis than by logistic regressions. These qualitative findings may prove generalizable beyond the study area, and may offer new approaches to understanding and increasing handpump functionality and safe water access. PMID:27667863

Understanding handpump sustainability: Determinants of rural water source functionality in the Greater Afram Plains region of Ghana

NASA Astrophysics Data System (ADS)

Fisher, Michael B.; Shields, Katherine F.; Chan, Terence U.; Christenson, Elizabeth; Cronk, Ryan D.; Leker, Hannah; Samani, Destina; Apoya, Patrick; Lutz, Alexandra; Bartram, Jamie

2015-10-01

Safe drinking water is critical to human health and development. In rural sub-Saharan Africa, most improved water sources are boreholes with handpumps; studies suggest that up to one third of these handpumps are nonfunctional at any given time. This work presents findings from a secondary analysis of cross-sectional data from 1509 water sources in 570 communities in the rural Greater Afram Plains (GAP) region of Ghana; one of the largest studies of its kind. 79.4% of enumerated water sources were functional when visited; in multivariable regressions, functionality depended on source age, management, tariff collection, the number of other sources in the community, and the district. A Bayesian network (BN) model developed using the same data set found strong dependencies of functionality on implementer, pump type, management, and the availability of tools, with synergistic effects from management determinants on functionality, increasing the likelihood of a source being functional from a baseline of 72% to more than 97% with optimal management and available tools. We suggest that functionality may be a dynamic equilibrium between regular breakdowns and repairs, with management a key determinant of repair rate. Management variables may interact synergistically in ways better captured by BN analysis than by logistic regressions. These qualitative findings may prove generalizable beyond the study area, and may offer new approaches to understanding and increasing handpump functionality and safe water access. This article was corrected on 11 Nov 2015. See the end of the full text for details.

FY2013 Advanced Power Electronics and Electric Motors R&D Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, Susan A.

The Advanced Power Electronics and Electric Motors (APEEM) technology area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE), electric motor, and traction drive system (TDS) technologies that will leapfrog current on-the-road technologies, leading to lower cost and better efficiency in transforming battery energy to useful work. The research and development (R&D) is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow’s automobiles will function as a unified system tomore » improve fuel efficiency through research in more efficient TDSs.« less

Food addiction as a proxy for eating disorder and obesity severity, trauma history, PTSD symptoms, and comorbidity.

PubMed

Brewerton, Timothy D

2017-06-01

Food addiction (FA) is a newly defined yet still controversial condition that has important etiological, developmental, treatment, prevention, and social policy implications. In this review, the case is made that FA (or high scores on the Yale Food Addiction Scale) may be used as a proxy measure for a matrix of interrelated clinical features, including greater eating disorder severity, greater obesity severity, more severe trauma histories, greater symptoms of posttraumatic stress disorder (PTSD), greater psychiatric comorbidity, as well as greater medical morbidity and mortality. A Medline search was undertaken using the following terms: food addiction cross-referenced with eating disorders (anorexia nervosa, bulimia nervosa, binge eating disorder, and binge eating), obesity, trauma, posttraumatic stress disorder, and comorbidity. The thesis is that the identification and acknowledgment of the concept of FA, when integrated into an overall, trauma-focused and transdiagnostic treatment approach, are supported and can be useful in understanding clinically the "big picture." Food addiction (FA) may be used as a proxy for (1) bulimic eating disorder severity, (2) complex trauma histories, (3) severity of PTSD and PTSD symptoms, (4) intensity of psychiatric comorbidity, (5) severity of obesity, as well as (6) their combination. Implications for developing treatment strategies are discussed. The case for a comprehensive management that requires careful attention to medical and psychiatric assessment and integrated care that incorporates trauma-focused treatment is made.

Rhinoviruses, Allergic Inflammation, and Asthma

PubMed Central

Gavala, Monica; Bertics, Paul J.; Gern, James E.

2011-01-01

Summary Viral infections affect wheezing and asthma in children and adults of all ages. In infancy, wheezing illnesses are usually viral in origin, and children with more severe wheezing episodes are more likely to develop recurrent episodes of asthma and to develop asthma later in childhood. Children who develop allergen-specific immunoglobulin E (allergic sensitization), and those who wheeze with rhinoviruses (HRV) are at especially high risk for asthma. In older children and adults, HRV infections generally cause relatively mild respiratory illnesses and yet contribute to acute and potentially severe exacerbations in patients with asthma. These findings underline the importance of understanding the synergistic nature of allergic sensitization and infections with HRV in infants relative to the onset of asthma and in children and adults with respect to exacerbations of asthma. This review discusses clinical and experimental evidence of virus/allergen interactions and evaluates theories which relate immunologic responses to respiratory viruses and allergens to the pathogenesis and disease activity of asthma. Greater understanding of the relationship between viral respiratory infections, allergic inflammation, and asthma is likely to suggest new strategies for the prevention and treatment of asthma. PMID:21682739

Yielding to Stress: Recent Developments in Viscoplastic Fluid Mechanics

NASA Astrophysics Data System (ADS)

Balmforth, Neil J.; Frigaard, Ian A.; Ovarlez, Guillaume

2014-01-01

The archetypal feature of a viscoplastic fluid is its yield stress: If the material is not sufficiently stressed, it behaves like a solid, but once the yield stress is exceeded, the material flows like a fluid. Such behavior characterizes materials common in industries such as petroleum and chemical processing, cosmetics, and food processing and in geophysical fluid dynamics. The most common idealization of a viscoplastic fluid is the Bingham model, which has been widely used to rationalize experimental data, even though it is a crude oversimplification of true rheological behavior. The popularity of the model is in its apparent simplicity. Despite this, the sudden transition between solid-like behavior and flow introduces significant complications into the dynamics, which, as a result, has resisted much analysis. Over recent decades, theoretical developments, both analytical and computational, have provided a better understanding of the effect of the yield stress. Simultaneously, greater insight into the material behavior of real fluids has been afforded by advances in rheometry. These developments have primed us for a better understanding of the various applications in the natural and engineering sciences.

[Health promotion. Instrument development for the application of the theory of planned behavior].

PubMed

Lee, Y O

1993-01-01

The purpose of this article is to describe operationalization of the Theory of Planned Behavior (TPB). The quest to understand determinants of health behaviors has intensified as evidence accumulates concerning the impact of personal behavior on health. The majority of theory-based research has used the Health Belief Model(HBM). The HBM components have had limited success in explaining health-related behaviors. There are several advantages of the TPB over the HBM. TPB is an expansion of the Theory of Reasoned Action(TRA) with the addition of the construct, perceived behavioral control. The revised model has been shown to yield greater explanatory power than the original TRA for goal-directed behaviors. The process of TPB instrument development was described, using example form the study of smoking cessation behavior in military smokers. It was followed by a discussion of reliability and validity issues in operationalizing the TPB. The TPB is a useful model for understanding and predicting health-related behaviors when carefully operationalized. The model holds promise in the development of prescriptive nursing approaches.

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

PubMed Central

Wheeler, Deric L.; Dunn, Emily F.; Harari, Paul M.

2010-01-01

EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. Following ligand binding, EGFR stimulates downstream cell signaling cascades that influence cell proliferation, apoptosis, migration, survival and complex processes, including angiogenesis and tumorigenesis. EGFR has been strongly implicated in the biology of human epithelial malignancies, with therapeutic applications in cancers of the colon, head and neck, lung, and pancreas. Accordingly, targeting EGFR has been intensely pursued, with the development of a series of promising molecular inhibitors for use in clinical oncology. As is common in cancer therapy, challenges with respect to treatment resistance emerge over time. This situation is certainly true of EGFR inhibitor therapies, where intrinsic and acquired resistance is now well recognized. In this Review, we provide a brief overview regarding the biology of EGFR biology, preclinical and clinical development of EGFR inhibitors, and molecular mechanisms that underlie the development of treatment resistance. A greater understanding of the mechanisms that lead to EGFR resistance may provide valuable insights to help design new strategies that will enhance the impact of this promising class of inhibitors for the treatment of cancer. PMID:20551942

Insights into early stage of antibiotic development in small- and medium-sized enterprises: a survey of targets, costs, and durations.

PubMed

Årdal, Christine; Baraldi, Enrico; Theuretzbacher, Ursula; Outterson, Kevin; Plahte, Jens; Ciabuschi, Francesco; Røttingen, John-Arne

2018-01-01

Antibiotic innovation has dwindled to dangerously low levels in the past 30 years. Since resistance continues to evolve, this innovation deficit can have perilous consequences on patients. A number of new incentives have been suggested to stimulate greater antibacterial drug innovation. To design effective solutions, a greater understanding is needed of actual antibiotic discovery and development costs and timelines. Small and medium-sized enterprises (SMEs) undertake most discovery and early phase development for antibiotics and other drugs. This paper attempts to gather a better understanding of SMEs' targets, costs, and durations related to discovery and early phase development of antibacterial therapies. DRIVE-AB, a project focused on developing new economic incentives to stimulate antibacterial innovation, held a European stakeholder meeting in February 2015. All SMEs invited to this meeting ( n  = 44) were subsequently sent a survey to gather more data regarding their areas of activity, completed and expected development costs and timelines, and business models. Twenty-five companies responded to the survey. Respondents were primarily small companies each focusing on developing 1 to 3 new antibiotics, focused on pathogens of public health importance. Most have not yet completed any clinical trials. They have reported ranges of discovery and development out-of-pocket costs that appear to be less expensive than other studies of general pharmaceutical research and development (R&D) costs. The duration ranges reported for completing each phase of R&D are highly variable when compared to previously published general pharmaceutical innovation average durations. However, our sample population is small and may not be fully representative of all relevant antibiotic SMEs. The data collected by this study provide important insights and estimates about R&D in European SMEs focusing on antibiotics, which can be combined with other data to design incentives to stimulate antibacterial innovation. The variation implies that costs and durations are difficult to generalize due to the unique characteristics of each antibiotic project and depend on individual business strategies and circumstances.

Cultural differences in clinical leadership: a qualitative study comparing the attitudes of general dental practitioners from Greater Manchester and Tokyo.

PubMed

Brocklehurst, P; Nomura, M; Ozaki, T; Ferguson, J; Matsuda, R

2013-11-01

Leadership has been argued to be a key component in the transformation of services in the United Kingdom and in Japan. In the UK, local professional networks have developed to provide clinician led care in dentistry; working to develop local plans to deliver improvements in the quality of care for patients. In Japan, the remuneration model for dental care has been revised with the aim to improve the service and tackle the current challenges of population health there. The aim of this study was to use semi-structured interviews and thematic analysis to explore general dental practitioners' (GDPs) understanding of the term 'leadership' and determine whether its meaning is culturally bound. Twelve participants were sampled purposively by the research team; identifying GDPs involved in leadership roles from across Greater Manchester and Tokyo. A set of open-ended questions was developed for semi-structured interviews a priori and the interviews continued until saturation. Interviews were recorded, transcribed verbatim and codes were developed into a coding frame for thematic analysis. Representative quotations are provided in the results. Fourteen codes were identified according to the aims of the study and organised into five overarching themes. 'Leadership as the relationship' was more pronounced among Japanese GDPs, while 'leadership as the individual' was common in GDPs from Greater Manchester. Differences were also found in respect of education and training in leadership. Training was also considered to be important by the GDPs from Japan, while UK GDPs felt leaders were more likely to be influenced by innate qualities. The interdependence of leadership and entrepreneurship was raised by both sets of GDPs. The concept of leadership was considered to be important by GDPs from both Greater Manchester and Tokyo; leadership was seen as providing strategy and direction for a clinical team. However, cultural influences were evident in how this was conceptualised.

Development and evaluation of theory-based diabetes support services.

PubMed

Guo, Sophie Huey-Ming; Lin, Yung-Hsiu; Chen, Rong-Rong; Kao, Shu-Fen; Chang, Her-Kun

2013-01-01

Technology-enabled support services for diabetes can fulfill patient demand to care for diabetes independently. Patients benefit from such services after greater adoption of the services in healthcare systems. Unfortunately, conventional service development fails to thoroughly understand patient care support, making it difficult to achieve the desired design, and posing substantial challenges in adopting these services. Thus, previously developed services in many cases are not as patients expected, as evidenced by their low acceptance among patients. To solve this problem, adequate strategies must be developed by incorporating theoretical knowledge as a solid foundation in order to improve service design. This study develops technology-enabled diabetes support services based on the self-care theory. A set of self-care service scenarios is also established and combined with theoretical concepts. The developed services consist of a nurse-led consultation service and a mobile application service. Additionally, user acceptance is confirmed by assessing patient perceptions of the diabetes support services in a group of patients with diabetes (N=27). Results of analysis reveal that patients respond favorably toward the services. Patient preference and perceived ease of use attest to their intention to use the services. Greater adoption of the services can be anticipated, owing to a higher levels of preference and higher perceived ease of use. This study demonstrated that the self-care theory can be linked to nursing informatics research and chronic care clinical practices.

Updates in the management of brain metastases

PubMed Central

Arvold, Nils D.; Lee, Eudocia Q.; Mehta, Minesh P.; Margolin, Kim; Alexander, Brian M.; Lin, Nancy U.; Anders, Carey K.; Soffietti, Riccardo; Camidge, D. Ross; Vogelbaum, Michael A.; Dunn, Ian F.; Wen, Patrick Y.

2016-01-01

The clinical management/understanding of brain metastases (BM) has changed substantially in the last 5 years, with key advances and clinical trials highlighted in this review. Several of these changes stem from improvements in systemic therapy, which have led to better systemic control and longer overall patient survival, associated with increased time at risk for developing BM. Development of systemic therapies capable of preventing BM and controlling both intracranial and extracranial disease once BM are diagnosed is paramount. The increase in use of stereotactic radiosurgery alone for many patients with multiple BM is an outgrowth of the desire to employ treatments focused on local control while minimizing cognitive effects associated with whole brain radiotherapy. Complications from BM and their treatment must be considered in comprehensive patient management, especially with greater awareness that the majority of patients do not die from their BM. Being aware of significant heterogeneity in prognosis and therapeutic options for patients with BM is crucial for appropriate management, with greater attention to developing individual patient treatment plans based on predicted outcomes; in this context, recent prognostic models of survival have been extensively revised to incorporate molecular markers unique to different primary cancers. PMID:27382120

Towards Increased Engagement of Geoscientists in Global Development Frameworks

NASA Astrophysics Data System (ADS)

Gill, Joel

2016-04-01

Geoscientists have the potential to make a significant contribution to tackling some of the major socio-environmental challenges of today, including extreme poverty, sustainable development, disaster risk reduction and climate change. This presentation explores the importance and social responsibility of geoscientists to engage in such work through understanding and supporting key global development frameworks. During 2015 the international community agreed three important agendas for change. Each framework relates to the intersection of environmental processes with human activities and behaviours, addressing significant challenges affecting society. The frameworks are (i) the UN Global Goals for Sustainable Development, (ii) the Sendai Framework for Disaster Risk Reduction 2015-2030, and (iii) subject to final confirmation at the time of writing, an agreement on climate change at the Paris Conference of the Parties - COP21. The UN Global Goals for Sustainable Development, for example, includes 17 goals aiming to end extreme poverty, fight inequality and ensure environmental sustainability. Specific goals relate to clean water and sanitation, clean and affordable energy, the development of resilient infrastructure, and the need for climate action. Given this context, here (i) a synthesis is presented of the role of geoscience in successfully achieving these major global development frameworks agreed in 2015, (ii) the ethical and social understanding that underpins effective engagement by geoscientists in the science-policy-practice interface is discussed, and (iii) this required ethical understanding is placed into the context of geoscience training and development needs. This approach demonstrates the importance of geoscientists from across all sectors and specialisms, engaging in the implementation, monitoring and evaluation of global development frameworks. It highlights the importance of a greater awareness and consideration of our ethical responsibilities in order to better support efforts to tackle major societal challenges.

Overcoming obstacles to implementation: addressing political, institutional and behavioral problems in earthquake hazard mitigation policies

NASA Astrophysics Data System (ADS)

Alesch, Daniel J.; Petak, William J.

2002-06-01

This project is aimed at bridging the three planes, from basic research, through enabling processes, to engineered systems. At the basic research plane, we have been working to improve our collective understanding about obstacles to implementing mitigation practices, owner decision processes (in connection with other MCEER projects), and public policy processes. At the level of enabling processes, we have been seeking to develop an understanding of how obstacles to greater mitigation can be overcome by improved policy design and processes. At the engineered systems plane, our work is intended to result in practical guidelines for devising policies and programs with appropriate motivation and incentives for implementing policies and programs once adopted. This phase of the research has been aimed, first, at a thorough, multidisciplinary review of the literature concerning obstacles to implementation. Second, the research has focused on advancing the state of the art by developing means for integrating the insights offered by diverse perspectives on the implementation process from the several social, behavioral, and decision sciences. The research establishes a basis for testing our understanding of these processes in the case of hospital retrofit decisions.

Cannabinoid-based medicines for neurological disorders--clinical evidence.

PubMed

Wright, Stephen

2007-08-01

Whereas the cannabis plant has a long history of medicinal use, it is only in recent years that a sufficient understanding of the pharmacology of the main plant constituents has allowed for a better understanding of the most rational therapeutic targets. The distribution of cannabinoid receptors, both within the nervous system and without, and the development of pharmacological tools to investigate their function has lead to a substantial increase in efforts to develop cannabinoids as therapeutic agents. Concomitant with these efforts, the understanding of the pharmacology of plant cannabinoids at receptor and other systems distinct from the cannabinoid receptors suggests that the therapeutic applications of plant-derived cannabinoids (and presumably their synthetic derivatives also) may be diverse. This review aims to discuss the clinical evidence investigating the use of medicines derived, directly or indirectly, from plant cannabinoids with special reference to neurological disorders. Published studies suggest that the oral administration of cannabinoids may not be the preferred route of administration and that plant extracts show greater evidence of efficacy than synthetic compounds. One of these, Sativex (GW Pharmaceuticals), was approved as a prescription medicine in Canada in 2005 and is currently under regulatory review in the EU.

Nutrigenetics of the lipoprotein metabolism.

PubMed

Garcia-Rios, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier; Lopez-Miranda, Jose; Perez-Jimenez, Francisco

2012-01-01

It is well known that lipid metabolism is a cornerstone in the development of the commonest important chronic diseases worldwide, such as obesity, cardiovascular disease, or metabolic syndrome. In this regard, the area of lipid and lipoprotein metabolism is one of the areas in which the understanding of the development and progression of those metabolic disorders has been studied in greater depth. Thus, growing evidence has demonstrated that while universal recommendations might be appropriate for the general population, in this area there is great variability among individuals, related to a combination of environmental and genetic factors. Moreover, the interaction between genetic and dietary components has helped in understanding this variability. Therefore, with further study into the interaction between the most important genetic markers or single-nucleotide polymorphisms (SNPs) and diet, it may be possible to understand the variability in lipid metabolism, which could lead to an increase in the use of personalized nutrition as the best support to combat metabolic disorders. This review discusses some of the evidence in which candidate SNPs can affect the key players of lipid metabolism and how their phenotypic manifestations can be modified by dietary intake. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Theoretical Approach to Understanding Population Dynamics with Seasonal Developmental Durations

NASA Astrophysics Data System (ADS)

Lou, Yijun; Zhao, Xiao-Qiang

2017-04-01

There is a growing body of biological investigations to understand impacts of seasonally changing environmental conditions on population dynamics in various research fields such as single population growth and disease transmission. On the other side, understanding the population dynamics subject to seasonally changing weather conditions plays a fundamental role in predicting the trends of population patterns and disease transmission risks under the scenarios of climate change. With the host-macroparasite interaction as a motivating example, we propose a synthesized approach for investigating the population dynamics subject to seasonal environmental variations from theoretical point of view, where the model development, basic reproduction ratio formulation and computation, and rigorous mathematical analysis are involved. The resultant model with periodic delay presents a novel term related to the rate of change of the developmental duration, bringing new challenges to dynamics analysis. By investigating a periodic semiflow on a suitably chosen phase space, the global dynamics of a threshold type is established: all solutions either go to zero when basic reproduction ratio is less than one, or stabilize at a positive periodic state when the reproduction ratio is greater than one. The synthesized approach developed here is applicable to broader contexts of investigating biological systems with seasonal developmental durations.

Understanding local community's values, worldviews and perceptions in the Galloway and Southern Ayrshire Biosphere Reserve, Scotland.

PubMed

Hernes, Maya I; Metzger, Marc J

2017-01-15

Biosphere reserves have been studied around the world, but methods to elicit community's values, worldviews and perceptions are missing. A greater understanding of these can help avoid tension and improve successful management. This paper used a mixed-methods survey to elicit local community's environmental values, ecological world views and perceptions of the Galloway and Southern Ayrshire Biosphere Reserve (GSABR). Over three weeks, forty participants from three communities of the GSABR responded to a semi-structured mixed-methods survey. The survey revealed that residents of the GSABR greatly value wildlife and beauty of nature, and that the majority of the respondents showed concern for the environment from an ecocentric worldview. Results also revealed that the most influential tested socio-demographic characteristic affecting people's relationship to their environment is their professional affiliation. Tourism and recreation were seen as major benefits of the recent biosphere designation. Results did highlight contrasting benefits from the designation for different stakeholder groups, which could potentially lead to tensions and should be considered in the reserve management. Given the community's supportive world views and perceptions, greater participation in the biosphere's management in likely to be welcomed and should be used to avoid or mediate any conflicts. The mixed-method survey developed for this study, proved successful in eliciting these themes in the GSABR. We recommend other biosphere reserves replicate this research, to gain better understanding of local communities and increase their support and participation in reserve management. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Mirror Has Two Faces: Contradictory Reflections of Donkeys in Western Literature from Lucius to Balthazar

PubMed Central

Bough, Jill

2011-01-01

Simple Summary I argue that cultural representations of donkeys arise from the contradictory philosophies that underpin western society. Donkeys have invariable been used symbolically in a negative way in early western literature which has affected our ongoing attitudes towards them: used as allegories for human nature, their own remains largely hidden. Tracing literary representations of donkeys reveals not only their conflicting origins but also how they developed over time. Understanding how these representations have affected our treatment of donkeys may lead to a better appreciation of the actual animals. Abstract How we represent animals both reflects our attitudes towards them and affects our treatment of them. The donkey has lived alongside humans, bearing their burdens since the time of their domestication over 10,000 years ago. Despite this, they have invariably enjoyed a low status in human cultures, received little appreciation and been treated harshly. We view some animals as being more worthy than others and represent them accordingly: donkeys have been ridiculed and derided. Literary representations of donkeys from the fables of Ancient Greece to contemporary iconic texts are explored to follow the donkey through the human imaginary. These representations derive from two main, conflicting sources, Greek literature and the Bible. Examining these cultural representations may lead towards a greater understanding of the way they affect the actual animal and lead to a greater understanding of that animal and, ultimately, to better treatment of them. PMID:26486214

Development and function of the midbrain dopamine system: what we know and what we need to.

PubMed

Bissonette, G B; Roesch, M R

2016-01-01

The past two decades have seen an explosion in our understanding of the origin and development of the midbrain dopamine system. Much of this work has been focused on the aspects of dopamine neuron development related to the onset of movement disorders such as Parkinson's disease, with the intent of hopefully delaying, preventing or fixing symptoms. While midbrain dopamine degeneration is a major focus for treatment and research, many other human disorders are impacted by abnormal dopamine, including drug addiction, autism and schizophrenia. Understanding dopamine neuron ontogeny and how dopamine connections and circuitry develops may provide us with key insights into potentially important avenues of research for other dopamine-related disorders. This review will provide a brief overview of the major molecular and genetic players throughout the development of midbrain dopamine neurons and what we know about the behavioral- and disease-related implications associated with perturbations to midbrain dopamine neuron development. We intend to combine the knowledge of two broad fields of neuroscience, both developmental and behavioral, with the intent on fostering greater discussion between branches of neuroscience in the service of addressing complex cognitive questions from a developmental perspective and identifying important gaps in our knowledge for future study. © 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

Social information-processing and coping in adolescent females diagnosed with an eating disorder: toward a greater understanding of control.

PubMed

McFillin, Roger K; Cahn, Stacey C; Burks, Virginia Salzer; Levine, Martha Peaslee; Loney, Susan Lane; Levine, Richard L

2012-01-01

The objective of this study was to examine differences in social information-processing and coping strategies between adolescent females in treatment for an eating disorder and asymptomatic peers. Adolescent females in treatment for an eating disorder (n = 50) were compared to asymptomatic control participants (n = 59) on a measure of social information-processing. Participants were presented with 4 hypothetical, ambiguous social dilemmas in which the intent of a peer provocateur was unclear. Questions followed each dilemma assessing intent attributions, the participant's emotional reaction, the intensity of the emotion, and coping strategies. The participants in treatment for an eating disorder were significantly more likely to perceive hostile intent from a peer provocateur, reported a greater intensity of negative emotions, and identified a significantly greater number of avoidant coping strategies. Specifically, the eating disorder group identified significantly more intrapunitive avoidant coping strategies that reflect maladaptive and self-destructive means of coping with distressing events. Results indicate social cognitive processing biases and maladaptive coping strategies may be instrumental in perceived loss of control and influence the development/maintenance of eating disorders.

An Experimental Study of a Pulsed Electromagnetic Plasma Accelerator

NASA Technical Reports Server (NTRS)

Thio, Y. C. Francis; Eskridge, Richard; Lee, Mike; Smith, James; Martin, Adam; Markusic, Tom E.; Cassibry, Jason T.; Rodgers, Stephen L. (Technical Monitor)

2002-01-01

Experiments are being performed on the NASA Marshall Space Flight Center (MSFC) pulsed electromagnetic plasma accelerator (PEPA-0). Data produced from the experiments provide an opportunity to further understand the plasma dynamics in these thrusters via detailed computational modeling. The detailed and accurate understanding of the plasma dynamics in these devices holds the key towards extending their capabilities in a number of applications, including their applications as high power (greater than 1 MW) thrusters, and their use for producing high-velocity, uniform plasma jets for experimental purposes. For this study, the 2-D MHD modeling code, MACH2, is used to provide detailed interpretation of the experimental data. At the same time, a 0-D physics model of the plasma initial phase is developed to guide our 2-D modeling studies.

Europe, the professions and interprofessional education: an exploration in inter-culture relativity.

PubMed

Lorenz, Walter

2009-09-01

This paper seeks to understand the inter-cultural relationships between the notions of Europe, the professions and interprofessional education (IPE) in developing an argument for the necessity of interprofessional education for meeting the complex challenges for the professions and society in the 21st century. The concept of "strange loops" is used to explore the paradoxes and recursions in understanding what Europe, the professions and interprofessional education really are. After questioning perceptions of the professions in a changing Europe, I challenge interprofessional education to greater heights. IPE has to accompany all professional exchanges across borders as a critical, constructive process that focuses on differences in theory and practice within the different professional fields to overcome their problems of adjustment to changing user needs and cultural requirements.

2-D Magnetohydrodynamic Modeling of A Pulsed Plasma Thruster

NASA Technical Reports Server (NTRS)

Thio, Y. C. Francis; Cassibry, J. T.; Wu, S. T.; Rodgers, Stephen L. (Technical Monitor)

2002-01-01

Experiments are being performed on the NASA Marshall Space Flight Center (MSFC) MK-1 pulsed plasma thruster. Data produced from the experiments provide an opportunity to further understand the plasma dynamics in these thrusters via detailed computational modeling. The detailed and accurate understanding of the plasma dynamics in these devices holds the key towards extending their capabilities in a number of applications, including their applications as high power (greater than 1 MW) thrusters, and their use for producing high-velocity, uniform plasma jets for experimental purposes. For this study, the 2-D MHD modeling code, MACH2, is used to provide detailed interpretation of the experimental data. At the same time, a 0-D physics model of the plasma initial phase is developed to guide our 2-D modeling studies.

LncRNA Structural Characteristics in Epigenetic Regulation

PubMed Central

Wang, Chenguang; Wang, Lianzong; Ding, Yu; Lu, Xiaoyan; Zhang, Guosi; Yang, Jiaxin; Zheng, Hewei; Wang, Hong; Jiang, Yongshuai; Xu, Liangde

2017-01-01

The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been shown to play important epigenetic regulatory roles in key molecular processes, such as gene expression, genetic imprinting, histone modification, chromatin dynamics, and other activities by forming specific structures and interacting with all kinds of molecules. This paper mainly discusses the correlation between the structure and function of lncRNAs with the recent progress in epigenetic regulation, which is important to the understanding of the mechanism of lncRNAs in physiological and pathological processes. PMID:29292750

Developing a pedagogy for nursing teaching-learning.

PubMed

Horsfall, Jan; Cleary, Michelle; Hunt, Glenn E

2012-11-01

Each nurse educator's pedagogy underpins their understanding of and approach to teaching and learning, regardless of whether this has been reflected upon or articulated. In this paper, we overview factors and issues that should be considered when developing a teaching philosophy of nursing education and set out broad differences between traditional and contemporary pedagogic models and various ways of knowing. As values underpin any teaching framework these are considered in relation to pedagogies, epistemologies and their relevance to nursing practice. Key teacher roles and strategies that are congruent with a contemporary pedagogy for teaching nursing in the classroom or the clinical setting are also outlined. A premise for writing this paper was that clarifying one's own understandings of education and knowledge and the implicit values held within those terms and processes will contribute to greater self-awareness and more effective teaching of nursing. Education approaches underpinned by a sound teaching philosophy and framework can facilitate an educationally sound and positive experience for learners. Copyright © 2011 Elsevier Ltd. All rights reserved.

Cerebral responses to exercise and the influence of heat stress in human fatigue.

PubMed

Robertson, Caroline V; Marino, Frank E

2017-01-01

There are a number of mechanisms thought to be responsible for the onset of fatigue during exercise-induced hyperthermia. A greater understanding of the way in which fatigue develops during exercise could be gleaned from the studies which have examined the maintenance of cerebral blood flow through the process of cerebral autoregulation. Given that cerebral blood flow is a measure of the cerebral haemodynamics, and might reflect a level of brain activation, it is useful to understand the implications of this response during exercise and in the development of fatigue. It is known that cerebral blood flow is significantly altered under certain conditions such as altitude and exacerbated during exercise induced - hyperthermia. In this brief review we consider the processes of cerebral autoregulation predominantly through the measurement of cerebral blood flow and contrast these responses between exercise undertaken in normothermic versus heat stress conditions in order to draw some conclusions about the role cerebral blood flow might play in determining fatigue. Copyright © 2016. Published by Elsevier Ltd.

Disruption of Fetal Hormonal Programming (Prenatal Stress) Implicates Shared Risk for Sex Differences in Depression and Cardiovascular Disease

PubMed Central

Goldstein, JM; Handa, RJ; Tobet, SA

2014-01-01

Comorbidity of major depressive disorder (MDD) and cardiovascular disease (CVD) represents the fourth leading cause of morbidity and mortality worldwide, and women have a two times greater risk than men. Thus understanding the pathophysiology has widespread implications for attenuation and prevention of disease burden. We suggest that sex-dependent MDD-CVD comorbidity may result from alterations in fetal programming consequent to the prenatal maternal environments that produce excess glucocorticoids, which then drive sex-dependent developmental alterations of the fetal hypothalamic-pituitary-adrenal (HPA) axis circuitry impacting mood, stress regulation, autonomic nervous system (ANS), and the vasculature in adulthood. Evidence is consistent with the hypothesis that disruptions of pathways associated with gamma aminobutyric acid (GABA) in neuronal and vascular development and growth factors have critical roles in key developmental periods and adult responses to injury in heart and brain. Understanding the potential fetal origins of these sex differences will contribute to development of novel sex-dependent therapeutics. PMID:24355523

Oligodendroglia: metabolic supporters of axons.

PubMed

Morrison, Brett M; Lee, Youngjin; Rothstein, Jeffrey D

2013-12-01

Axons are specialized extensions of neurons that are critical for the organization of the nervous system. To maintain function in axons that often extend some distance from the cell body, specialized mechanisms of energy delivery are likely to be necessary. Over the past decade, greater understanding of human demyelinating diseases and the development of animal models have suggested that oligodendroglia are critical for maintaining the function of axons. In this review, we discuss evidence for the vulnerability of neurons to energy deprivation, the importance of oligodendrocytes for axon function and survival, and recent data suggesting that transfer of energy metabolites from oligodendroglia to axons through monocarboxylate transporter 1 (MCT1) may be critical for the survival of axons. This pathway has important implications both for the basic biology of the nervous system and for human neurological disease. New insights into the role of oligodendroglial biology provide an exciting opportunity for revisions in nervous system biology, understanding myelin-based disorders, and therapeutics development. Copyright © 2013 Elsevier Ltd. All rights reserved.

A review of late-stage CNS drug candidates for the treatment of obesity.

PubMed

Heal, D J; Gosden, J; Smith, S L

2013-01-01

Obesity is an important causative factor in morbidity, disability and premature death. Increasing levels of obesity will impose enormous health, financial and social burdens on worldwide society unless effective interventions are implemented. For many obese individuals, diet and behavioural modification need to be supplemented by pharmacotherapy. Preclinical research has revealed a greater understanding of the complex nature of the hypothalamic regulation of food intake and has generated a wide range of new molecular targets for the development of drug candidates for obesity treatment. As shown by the clinical results that have been obtained with this next generation of therapies, some approaches, for example, fixed-dose drug combinations, have already demonstrated an ability to deliver levels of efficacy that are not achievable with the current antiobesity drug therapies. The regulatory and marketing landscape for development, registration and commercialisation of novel centrally acting drugs for treatment of obesity and related metabolic disorders has changed substantially in recent years. Now a much greater emphasis is placed on tolerability and safety, as well as efficacy. In this review we briefly describe the therapeutic approaches to tackle obesity that are in late-stage clinical development. We then discuss drugs in late-stage development for the treatment of obesity and also future directions.

Process and impact evaluation of the Greater Christchurch Urban Development Strategy Health Impact Assessment

PubMed Central

Mathias, Kaaren R; Harris-Roxas, Ben

2009-01-01

Background despite health impact assessment (HIA) being increasingly widely used internationally, fundamental questions about its impact on decision-making, implementation and practices remain. In 2005 a collaboration between public health and local government authorities performed an HIA on the Christchurch Urban Development Strategy Options paper in New Zealand. The findings of this were incorporated into the Greater Christchurch Urban Development Strategy; Methods using multiple qualitative methodologies including key informant interviews, focus groups and questionnaires, this study performs process and impact evaluations of the Christchurch HIA including evaluation of costs and resource use; Results the evaluation found that the HIA had demonstrable direct impacts on planning and implementation of the final Urban Development Strategy as well as indirect impacts on understandings and ways of working within and between organisations. It also points out future directions and ways of working in this successful collaboration between public health and local government authorities. It summarises the modest resource use and discusses the important role HIA can play in urban planning with intersectoral collaboration and enhanced relationships as both catalysts and outcomes of the HIA process; Conclusion as one of the few evaluations of HIA that have been published to date, this paper makes a substantial contribution to the literature on the impact, utility and effectiveness of HIA. PMID:19344529

Borderless STEM education: A study of both American students and foreign students

NASA Astrophysics Data System (ADS)

Komura, Kiriko

This study explores the current status of borderless education in STEM through surveys of two populations of STEM students: American students who studied abroad and foreign students who were studying in the U.S. It was undertaken in response to the U.S. government's desires to strengthen STEM education and to develop American students' global competencies. The purpose was to understand how international experiences can be enhanced in order to increase American STEM students' interest in study abroad programs and in earning advanced STEM degrees and to understand how to attract more foreign STEM students to study in the United States. Issues of particular focus were: the impacts of gender, race/ethnicity, and nationality on STEM students' motivation to participate in, and responses to study abroad programs, and the value of Information and Communication Technologies (ICTs) in borderless STEM education. Several different forms of multivariate analyses were performed on data from surveys at seven public and private colleges and universities in the Southern California area. The results indicated that among American students, greater value was placed on social and cultural experiences gained through studying abroad. In contrast, among foreign students greater value was placed on enhancement of their academic and professional development opportunities. American students whose study abroad included research experiences had a greater interest in international research and teaching in the future. Foreign graduate students majoring in computer science, engineering and biology are the most likely to seek opportunities to study and work in the US. Finally, ICTs were valued by American students as platforms for social interactions and by foreign students for facilitating professional networks. The analyses lead to several recommendations, including: STEM faculty should be made aware of the critical importance of their advising and mentoring in motivating students to choose to study abroad and, minority students gain more confidence about working in STEM fields and seeking advanced STEM degrees as a result of studying abroad.

Professional development for university scientists around issues of equity and diversity: Investigating dissent within community

NASA Astrophysics Data System (ADS)

Bianchini, Julie A.; Hilton-Brown, Bryan A.; Breton, Therese D.

2002-10-01

We investigated the role of dissent in a community of university scientists, engineers, mathematicians, and social scientists engaged in a 2-year professional development project around issues of equity and diversity. Members of this teacher learning community explored issues related to gender and ethnicity in science education, and attempted to develop course materials and instructional strategies inclusive of students from underrepresented groups. We focused our attention on those professional development sessions (6 of the 19) devoted to a contentious yet integral topic in science education: the gendered and multicultural nature of science. We examined conversations initiated by a member's concerns to learn how dissent led (or failed to lead) to new insights into feminist science studies scholarship or to greater understanding of ways to address equity issues in undergraduate science education. We also explored how teacher learners' resulting views of feminist science studies scholarship informed (or failed to inform) changes in their own educational practices. From our qualitative analyses, we highlight the challenges in balancing respect for members' individual voices with collective progress toward project goals, and in structuring conversations initiated by dissent to provide adequate space for deliberation and movement toward deeper understanding of equity and excellence.

Cross-sectional associations between psychological traits, and HPV vaccine uptake and intentions in young adults from the United States.

PubMed

Scherer, Aaron M; Schacht Reisinger, Heather; Schweizer, Marin L; Askelson, Natoshia M; Fagerlin, Angela; Lynch, Charles F

2018-01-01

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide and can lead to the development of genital warts, and cancers throughout the body. Despite the availability of HPV vaccines for over a decade, uptake in the United States among adolescents and young adults remains well below national targets. While most efforts to improve HPV vaccine uptake have rightly focused on adolescents, there is still a tremendous opportunity to improve vaccination among young adults who have not been vaccinated against HPV. To that end, we report an exploratory examination of associations between HPV vaccination status and intentions with psychological traits that may impact HPV vaccine uptake with a national, demographically diverse sample of young adults (N = 1358) who completed an online survey. These psychological traits conceptually mapped onto motivations to: 1) understand health-related information, 2) deliberate, 3) manage uncertainty, and 4) manage threats. We found notable gender differences for the association of these motivations and vaccination status. For women, higher interest in and ability to understand health-related information seemed to distinguish those who reported receiving the HPV vaccine from those who did not. For men, less need to deliberate and greater needs to manage threat and uncertainty seemed to be the distinguishing motives for those who reported receiving the HPV vaccine compared to those who did not. Results for vaccination intentions were less consistent, but there was some evidence to indicate that, regardless of gender, greater health-related information interest and understanding and need to manage uncertainty and threats were associated with increased intention to receive the HPV vaccine, while greater need to deliberate was associated with decreased vaccination intentions. These results suggest that there are psychological differences that are associated with HPV vaccination decisions and that these motivations should be considered in efforts to improve HPV vaccine uptake.

Evaluating and understanding fish health risks and their consequences in propagated and free-ranging fish populations

USGS Publications Warehouse

Moffitt, C.M.; Haukenes, A.H.; Williams, C.J.

2005-01-01

Fishery managers and resource conservationists are increasingly interested in understanding the fish health and disease risks of free-ranging fishes and whether propagated fishes or features and practices used at fish culture facilities pose a health risk to free-ranging populations. Disease agents are present in most both captive and all free-ranging fish populations, but the consequences and extent of infections in free-ranging populations are often difficult to measure, control, and understand. Sampling methods, protocols, and assay techniques developed to assess the health of captive populations are not as applicable for assessments of free-ranging fishes. The use of chemicals and therapeutics to control diseases and parasites in propagated fishes likely reduces the risk of introducing specific pathogens into the environment, but control measures may have localized effects on the environment surrounding fish culture facilities. To understand health risks of propagated and free ranging fishes, we must consider fish populations, culture facilities, fish releases, and their interactions within the greater geospatial features of the aquatic environment. ?? 2004 by the American Fisheries Society.

Evolutionary accounts of human behavioural diversity

PubMed Central

Brown, Gillian R.; Dickins, Thomas E.; Sear, Rebecca; Laland, Kevin N.

2011-01-01

Human beings persist in an extraordinary range of ecological settings, in the process exhibiting enormous behavioural diversity, both within and between populations. People vary in their social, mating and parental behaviour and have diverse and elaborate beliefs, traditions, norms and institutions. The aim of this theme issue is to ask whether, and how, evolutionary theory can help us to understand this diversity. In this introductory article, we provide a background to the debate surrounding how best to understand behavioural diversity using evolutionary models of human behaviour. In particular, we examine how diversity has been viewed by the main subdisciplines within the human evolutionary behavioural sciences, focusing in particular on the human behavioural ecology, evolutionary psychology and cultural evolution approaches. In addition to differences in focus and methodology, these subdisciplines have traditionally varied in the emphasis placed on human universals, ecological factors and socially learned behaviour, and on how they have addressed the issue of genetic variation. We reaffirm that evolutionary theory provides an essential framework for understanding behavioural diversity within and between human populations, but argue that greater integration between the subfields is critical to developing a satisfactory understanding of diversity. PMID:21199836

Development and application of a mobile laboratory for measuring emissions from diesel engines. 2. Sampling for toxics and particulate matter.

PubMed

Cocker, David R; Shah, Sandip D; Johnson, Kent C; Zhu, Xiaona; Miller, J Wayne; Norbeck, Joseph M

2004-12-15

Limited data are available on the emission rates of speciated volatile and semivolatile organic compounds, as well as the physical and chemical characteristics of fine particulate matter (PM) from mobile, in-use diesel engines operated on the road. A design for the sampling of these fractions and the first data from in-use diesel sources are presented in this paper. Emission rates for carbonyls, 1,3-butadiene, benzene, toluene, xylene, PM, and elemental and organic carbon (EC and OC) are reported for a vehicle driven while following the California Air Resources Board (ARB) four-mode heavy heavy-duty diesel truck (HHDDT) cycle and while transiting through a major transportation corridor. Results show that distance specific emission rates are substantially greater in congested traffic as compared with highway cruise conditions. Specifically, emissions of toxic compounds are 3-15 times greater, and PM is 7 times greater under these conditions. The dependence of these species on driving mode suggests that health and source apportionment studies will need to account for driving patterns in addition to emission factors. Comparison of the PM/NOx ratios obtained for the above tests provides insight into the presence and importance of "off-cycle" emissions during on-road driving. Measurements from a stationary source (operated and tested at constant engine speed) equipped with an engine similar to that in the HHDDT yielded a greater understanding of the relative dependence of emissions on load versus engine transients. These data are indicative of the type of investigations made possible by the development of this novel laboratory.

The Public Understanding of Science: 30 Years of the Bodmer Report

ERIC Educational Resources Information Center

Short, Daniel B.

2013-01-01

As research probes deeper into all aspects of science, greater specialisation is required. This natural progression takes knowledge and understanding further away from the general public. Hence part of the responsibility of scientists is to communicate that knowledge at an appropriate level of understanding. As most people do not actively follow…

Idiom understanding in adulthood: examining age-related differences.

PubMed

Hung, Pei-Fang; Nippold, Marilyn A

2014-03-01

Idioms are figurative expressions such as hold your horses, kick the bucket, and lend me a hand, which commonly occur in everyday spoken and written language. Hence, the understanding of these expressions is essential for daily communication. In this study, we examined idiom understanding in healthy adults in their 20s, 40s, 60s and 80s (n=30 per group) to determine if performance would show an age-related decline. Participants judged their own familiarity with a set of 20 idioms, explained the meaning of each, described a situation in which the idiom could be used, and selected the appropriate interpretation from a set of choices. There was no evidence of an age-related decline on any tasks. Rather, the 60s group reported greater familiarity and offered better explanations than did the 20s group. Moreover, greater familiarity with idioms was associated with better understanding in adults.

Cambodian students’ prior knowledge of projectile motion

NASA Astrophysics Data System (ADS)

Piten, S.; Rakkapao, S.; Prasitpong, S.

2017-09-01

Students always bring intuitive ideas about physics into classes, which can impact what they learn and how successful they are. To examine what Cambodian students think about projectile motion, we have developed seven open-ended questions and applied into grade 11 students before (N=124) and after (N=131) conventional classes. Results revealed several consistent misconceptions, for instance, many students believed that the direction of a velocity vector of a projectile follows the curved path at every position. They also thought the direction of an acceleration (or a force) follows the direction of motion. Observed by a pilot sitting on the plane, the falling object, dropped from a plane moving at a constant initial horizontal speed, would travel backward and land after the point of its release. The greater angle of the launched projectile creates the greater horizontal range. The hand force imparted with the ball leads the ball goes straight to hit the target. The acceleration direction points from the higher position to lower position. The misconceptions will be used as primary resources to develop instructional instruments to promote Cambodian students’ understanding of projectile motion in the following work.

A scoping review identifying contemporary issues in rural nursing leadership.

PubMed

Bish, Melanie; Kenny, Amanda; Nay, Rhonda

2012-12-01

Rural nurse leaders on a global scale are being challenged to create structures and processes to enable excellence in nursing care. The purpose of this scoping review is to offer an indication of the available literature relating to contemporary issues in rural nursing leadership. A review of contemporary issues facing rural nurse leaders is timely to assist strategy development that will achieve the goal of excellence in nursing. An interpretative scoping literature review methodological framework has been used with an emphasis on thematic construction. Literature published between 2008 and 2012 was reviewed from five electronic databases using the key words rural, nursing, and leadership. Four themes have been identified: expectations of rural nursing leadership, a highly educated workforce, competing interests, and partnering within rural healthcare systems. The content may resonate with rural nurse leaders and encourage a greater awareness of their relevance to leadership practices. The findings provide a greater awareness and understanding of contemporary issues facing rural nurse leaders and may assist with the development of context-sensitive leadership strategies to facilitate excellence in nursing care. © 2012 Sigma Theta Tau International.

Rumination and Perceived Impairment Associated with Depressive Symptoms in a Verbal Adolescent-Adult ASD Sample

PubMed Central

Gotham, Katherine; Bishop, Somer L.; Brunwasser, Steven; Lord, Catherine

2015-01-01

The aim of this study was to examine the association between depressive symptoms and several psychosocial constructs (insight into autism symptoms, rumination, desire for social interaction, and satisfaction with social support) that may play a role in the development or maintenance of depression in verbally fluent adolescents and adults with ASD. Participants included 50 individuals with ASD and verbal IQ >= 70, aged 16-35 (sample size varied by measure). Elevated depressive symptoms on the Beck Depression Inventory, 2nd edition, were associated with greater self-perceived autism-related impairments (n=48), greater rumination (n=21), and lower perceived social support (n=37). Rumination tended to moderate the association between self-perceived autism symptoms and BDI-II scores (n=21), and was significantly associated with ASD-related Insistence on Sameness behaviors (n=18). An unexpected relationship between depressive features and social participation and motivation will need to be clarified by longitudinal research. These and similar findings contribute to our understanding of the phenomenology of depression in ASD, which is critical to the development of practical prevention and treatment. PMID:24802136

How children remember the Strange Situation: The role of attachment.

PubMed

Chae, Yoojin; Goodman, Miranda; Goodman, Gail S; Troxel, Natalie; McWilliams, Kelly; Thompson, Ross A; Shaver, Phillip R; Widaman, Keith F

2018-02-01

This study tested predictions from Bowlby's attachment theory about children's memory and suggestibility. Young children (3-5years old, N=88; 76% Caucasians) and their parents took part in the Strange Situation Procedure, a moderately distressing event and "gold standard" for assessing children's attachment quality. The children were then interviewed about what occurred during the event. Children's age and attachment security scores positively predicted correct information in free recall and accuracy in answering specific questions. For children with higher (vs. lower) attachment security scores, greater distress observed during the Strange Situation Procedure predicted increased resistance to misleading suggestions. In addition, for children who displayed relatively low distress during the Strange Situation Procedure, significant age differences in memory and suggestibility emerged as expected. However, for children who displayed greater distress during the Strange Situation Procedure, younger and older children's memory performances were equivalent. Findings suggest that attachment theory provides an important framework for understanding facets of memory development with respect to attachment-related information and that distress may alter assumed age patterns in memory development. Copyright © 2017 Elsevier Inc. All rights reserved.

Can we prevent ischemic-type biliary lesions in donation after circulatory determination of death liver transplantation?

PubMed

Hessheimer, Amelia J; Cárdenas, Andrés; García-Valdecasas, Juan C; Fondevila, Constantino

2016-07-01

The pool of livers for transplantation consists of an increasingly greater proportion of marginal grafts, in particular those arising through donation after circulatory determination of death (DCD). However, a primary factor limiting the use of marginal livers, and, thereby, the applicability of liver transplantation in general, is concern over the subsequent development of ischemic-type biliary lesion (ITBL). ITBL is a devastating complication of liver transplantation; in its most severe forms, recipients suffer frequent infectious complications that require repeated invasive biliary procedures and ultimately result in either retransplantation or death. In the present review article, we discuss our current understanding of ITBL pathogenesis as it pertains to DCD, in particular. We discuss the most relevant theories regarding its development and provide a comprehensive overview of the most promising strategies we have available today to prevent the appearance of ITBL, strategies that may, furthermore, allow us to transplant a greater proportion of marginal livers in the future. Liver Transplantation 22 1025-1033 2016 AASLD. © 2016 American Association for the Study of Liver Diseases.

Exercise as a countermeasure for physiological adaptation to prolonged spaceflight

NASA Technical Reports Server (NTRS)

Convertino, V. A.

1996-01-01

Exercise represents the primary countermeasure used during spaceflight to maintain or restore maximal aerobic capacity (VO2max), musculoskeletal structure, and orthostatic function. However, no single exercise or combination of prescriptions has proven entirely effective in restoring cardiovascular and musculoskeletal functions to preflight levels following prolonged spaceflight. As human spaceflight exposures increase in duration, assessment and development of various effective exercise-based protective procedures become paramount. This must involve improvement in specific countermeasure prescription as well as development of additional approaches that will allow space travelers greater flexibility and medical safety during long flights. Effective exercise prescription will be based on identification of basic physiological stimuli that maintain normal function in terrestrial gravity and understanding of how specific combinations of exercise characteristics e.g., duration, frequency, intensity, mode) can mimic these stimuli and affect the overall process of adaptation to microgravity. This can be accomplished only with greater emphasis of research on ground-based experiments. Future attention must be directed to improving exercise compliance while minimizing both crew time and the impact of the exercise on life-support resources.

Dry eye after laser in-situ keratomileusis.

PubMed

Raoof, Duna; Pineda, Roberto

2014-01-01

Laser-assisted in-situ keratomileusis (LASIK) is one of the most commonly performed refractive procedures with excellent visual outcomes. Dry eye syndrome is one of the most frequently seen complications after LASIK, with most patients developing at least some mild dry eye symptoms postoperatively. To achieve improved visual outcomes and greater patient satisfaction, it is essential to identify patients prone to dry eyes preoperatively, and initiate treatment early in the course. Enhanced understanding of the pathophysiology of post-LASIK dry eye will help advance our approach to its management.

From Diagnosis to Gnosis: writing, knowledge, and repair in breast cancer and BRCA memoirs.

PubMed

Boesky, Amy

2015-01-01

This essay explores the reparative work of diagnostic retellings in breast cancer and BRCA memoirs (memoirs written by women who learn they carry a mutation predisposing them to develop breast or ovarian cancers). It considers four memoirists (Felicia Knaul, Melanie Norton, Masha Gessen, and Sarah Gabriel) as they illuminate initial moments of "finding out"--learning they have cancer or have tested positive for a BRCA mutation. These memoirists invite readers to appreciate the complexity of cancer as a lived experience. Writing about breast cancer and the risk of its development helps writers and readers alike to understand illness in greater depth, challenging some aspects of care and championing others.

Information-seeking strategies and science content understandings of sixth-grade students using on-line learning environments

NASA Astrophysics Data System (ADS)

Hoffman, Joseph Loris

1999-11-01

This study examined the information-seeking strategies and science content understandings learners developed as a result of using on-line resources in the University of Michigan Digital Library and on the World Wide Web. Eight pairs of sixth grade students from two teachers' classrooms were observed during inquiries for astronomy, ecology, geology, and weather, and a final transfer task assessed learners' capabilities at the end of the school year. Data included video recordings of students' screen activity and conversations, journals and completed activity sheets, final artifacts, and semi-structured interviews. Learners' information-seeking strategies included activities related to asking, planning, tool usage, searching, assessing, synthesizing, writing, and creating. Analysis of data found a majority of learners posed meaningful, openended questions, used technological tools appropriately, developed pertinent search topics, were thoughtful in queries to the digital library, browsed sites purposefully to locate information, and constructed artifacts with novel formats. Students faced challenges when planning activities, assessing resources, and synthesizing information. Possible explanations were posed linking pedagogical practices with learners' growth and use of inquiry strategies. Data from classroom-lab video and teacher interviews showed varying degrees of student scaffolding: development and critique of initial questions, utilization of search tools, use of journals for reflection on activities, and requirements for final artifacts. Science content understandings included recalling information, offering explanations, articulating relationships, and extending explanations. A majority of learners constructed partial understandings limited to information recall and simple explanations, and these occasionally contained inaccurate conceptualizations. Web site design features had some influence on the construction of learners' content understandings. Analysis of data suggests sites with high quality general design, navigation, and content helped to foster the construction of broad and accurate understandings, while context and interactivity had less impact. However, student engagement with inquiry strategies had a greater impact on the construction of understandings. Gaining accurate and in-depth understandings from on-line resources is a complex process for young learners. Teachers can support students by helping them engage in all phases of the information-seeking process, locate useful information with prescreened resources, build background understanding with off-line instruction, and process new information deeply through extending writing and conversation.

Greater sage-grouse: General use and roost site occurrence with pellet counts as a measure of relative abundance: Chapter 5

USGS Publications Warehouse

2011-01-01

Greater sage-grouse (Centrocercus urophasianus) have been declining both spatially and numerically throughout their range because of anthropogenic disturbance and loss and fragmentation of sagebrush (Artemisia spp.) habitats. Understanding how sage-grouse respond to these habitat alterations and disturbances, particularly the types of disturbances and extent at which they respond, is critical to designing management actions and prioritizing areas of conservation. To address these needs, we developed statistical models of the relationships between occurrence and abundance of greater sage-grouse and multi-scaled measures of vegetation, abiotic, and disturbance in the Wyoming Basins Ecoregional Assessment (WBEA) area. Sage-grouse occurrence was strongly related to the amount of sagebrush within 1 km for both roost site and general use locations. Roost sites were identified by presence of sage-grouse fecal pellet groups whereas general use locations had single pellets. Proximity to anthropogenic disturbance including energy development, power lines, and major roads was negatively associated with sage-grouse occurrence. Models of sage-grouse occurrence correctly predicted active lek locations with >75% accuracy. Our spatially explicit models identified areas of high occurrence probability in the WBEA area that can be used to delineate areas for conservation and refine existing conservation plans. These models can also facilitate identification of pathways and corridors important for maintenance of sage-grouse population connectivity.

Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation.

PubMed

Herman, William H; Pan, Qing; Edelstein, Sharon L; Mather, Kieren J; Perreault, Leigh; Barrett-Connor, Elizabeth; Dabelea, Dana M; Horton, Edward; Kahn, Steven E; Knowler, William C; Lorenzo, Carlos; Pi-Sunyer, Xavier; Venditti, Elizabeth; Ye, Wen

2017-12-01

Both lifestyle and metformin interventions can delay or prevent progression to type 2 diabetes mellitus (DM) in people with impaired glucose regulation, but there is considerable interindividual variation in the likelihood of receiving benefit. Understanding an individual's 3-year risk of progressing to DM and regressing to normal glucose regulation (NGR) might facilitate benefit-based tailored treatment. We used the values of 19 clinical variables measured at the Diabetes Prevention Program (DPP) baseline evaluation and Cox proportional hazards models to assess the 3-year risk of progression to DM and regression to NGR separately for DPP lifestyle, metformin, and placebo participants who were adherent to the interventions. Lifestyle participants who lost ≥5% of their initial body weight at 6 months and metformin and placebo participants who reported taking ≥80% of their prescribed medication at the 6-month follow-up were defined as adherent. Eleven of 19 clinical variables measured at baseline predicted progression to DM, and 6 of 19 predicted regression to NGR. Compared with adherent placebo participants at lowest risk of developing diabetes, participants at lowest risk of developing diabetes who adhered to a lifestyle intervention had an 8% absolute risk reduction (ARR) of developing diabetes and a 35% greater absolute likelihood of reverting to NGR. Participants at lowest risk of developing diabetes who adhered to a metformin intervention had no reduction in their risk of developing diabetes and a 17% greater absolute likelihood of reverting to NGR. Participants at highest risk of developing DM who adhered to a lifestyle intervention had a 39% ARR of developing diabetes and a 24% greater absolute likelihood of reverting to NGR, whereas those who adhered to the metformin intervention had a 25% ARR of developing diabetes and an 11% greater absolute likelihood of reverting to NGR. Unlike our previous analyses that sought to explain population risk, these analyses evaluate individual risk. The models can be used by overweight and obese adults with fasting hyperglycemia and impaired glucose tolerance to facilitate personalized decision-making by allowing them to explicitly weigh the benefits and feasibility of the lifestyle and metformin interventions. © 2017 by the American Diabetes Association.

Studying brain-regulation of immunity with optogenetics and chemogenetics; A new experimental platform.

PubMed

Ben-Shaanan, Tamar; Schiller, Maya; Rolls, Asya

2017-10-01

The interactions between the brain and the immune system are bidirectional. Nevertheless, we have far greater understanding of how the immune system affects the brain than how the brain affects immunity. New technological developments such as optogenetics and chemogenetics (using DREADDs; Designer Receptors Exclusively Activated by Designer Drugs) can bridge this gap in our understanding, as they enable an unprecedented mechanistic and systemic analysis of the communication between the brain and the immune system. In this review, we discuss new experimental approaches for revealing neuronal circuits that can participate in regulation of immunity. In addition, we discuss methods, specifically optogenetics and chemogenetics, that enable targeted neuronal manipulation to reveal how different brain regions affect immunity. We describe how these techniques can be used as an experimental platform to address fundamental questions in psychoneuroimmunology and to understand how neuronal circuits associate with different psychological states can affect physiology. Copyright © 2016 Elsevier Inc. All rights reserved.

Technique for assessing vegetation-induced moisture flux, with implications for global climate modeling

NASA Technical Reports Server (NTRS)

Macari, Emir Jose

1990-01-01

The time between storms, the duration of storms, and the storm depths are studied in relation to vegetation controls on the disposition of rainfall. It is proposed that understanding the movement of water between the vegetation and soil (including evapotranspiration and infiltration) will be the gateway for modeling atmospheric flux and improving global climate models. The overall objective goal of the proposed research effort is to develop a field/lab methodology which will provide a better understanding of vegetation induced water movement. Water flow initiated from stem flow of wooded slopes feeds soil water pathways, which in turn feed the deeper ground water system and give rise to stream response. This is balanced by more water inputs via throughfall, where it percolates the soil matrix and allows much greater rates of evapotranspiration and atmospheric/soil moisture flux. This research study seeks to gain an understanding of the effect of vegetation on soil moisture, and the effect of this differential wetting on resulting evapotranspiration and atmospheric flux.

Theory and practice in sport psychology and motor behaviour needs to be constrained by integrative modelling of brain and behaviour.

PubMed

Keil, D; Holmes, P; Bennett, S; Davids, K; Smith, N

2000-06-01

Because of advances in technology, the non-invasive study of the human brain has enhanced the knowledge base within the neurosciences, resulting in an increased impact on the psychological study of human behaviour. We argue that application of this knowledge base should be considered in theoretical modelling within sport psychology and motor behaviour alongside existing ideas. We propose that interventions founded on current theoretical and empirical understanding in both psychology and the neurosciences may ultimately lead to greater benefits for athletes during practice and performance. As vehicles for exploring the arguments of a greater integration of psychology and neurosciences research, imagery and perception-action within the sport psychology and motor behaviour domains will serve as exemplars. Current neuroscience evidence will be discussed in relation to theoretical developments; the implications for sport scientists will be considered.

Therapeutic alliance, illness awareness, and number of hospitalizations for schizophrenia.

PubMed

Prince, Jonathan D

2007-02-01

While persons with multiple hospitalizations for schizophrenia have been found to differ from those with fewer, it remains unclear whether differences exist in illness awareness (personal understanding of psychopathology) or therapeutic alliance with inpatient staff (treatment involvement). This cross-sectional descriptive study therefore examined whether inpatients with more extensive hospitalization history 1) have less illness awareness and therapeutic alliance (perhaps contributing to the recidivism), 2) have more awareness and alliance (possibly because they have learned from experience), or 3) do not differ relative to persons with fewer inpatient stays. Results from staff and patient interviews (N=307) suggest that illness awareness is greater in persons with more hospitalizations, while therapeutic alliance appears to weaken. Individuals with greater recidivism may therefore need less help than others in building a self-knowledge of psychopathology that may already have developed. Instead, enhanced engagement in care may be more important after multiple disappointing relapses.

Workplace Exposures and Cognitive Function During Adulthood: Evidence From National Survey of Midlife Development and the O*NET.

PubMed

Grzywacz, Joseph G; Segel-Karpas, Dikla; Lachman, Margie E

2016-06-01

Expand understanding of the role of selected workplace exposures (ie, occupational complexity, conflict in the workplace, pace of work, and physical hazards) in adults' cognitive function. Cross-sectional data (n = 1991) from the second wave of the Midlife in the United States (MIDUS) study; restricted to participants who completed telephone-based cognitive assessments of episodic memory, executive functioning, and self-perceived memory. Occupational exposure data were harvested from the ONET Release 6.0. Greater complexity was associated with better self-perceived memory among women and men, and better episodic memory and executive functioning among women. Greater physical hazards were independently associated with poorer episodic memory and executive functioning. Objective assessments of physical and psychosocial exposures in the workplace are independently associated with cognitive outcomes in adulthood, with psychosocial exposures being particularly pronounced among women.

A re-evaluation of project pride, a redesigned school-based drug abuse prevention program.

PubMed

LoSciuto, Leonard; Steinman, Ross B

2004-01-01

The present study examined the effectiveness of Project PRIDE, a school-based, counselor-administered, drug and alcohol prevention program. The study is presented in the context of Project PRIDE'S efforts to keep itself current and effective via continual evaluation-based development. In this outcome evaluation, Project PRIDE participants demonstrated greater pretest to posttest gains on five of six outcome measures compared to control students, although many of the changes were small or moderate and only two were statistically significant. Further, as predicted, gains in more factual or objective areas of the program were greater than in more subjective areas dealing with student perceptions and feelings. The limitations and implications of the findings are discussed. Also discussed are the advantages of the Binomial Effect Size Display as a data presentation mode that promotes both client and general audience understanding of results.

The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children

PubMed Central

Farr, Joshua N.; Dimitri, Paul

2016-01-01

A complex interplay of genetic, environmental, hormonal, and behavioral factors affect skeletal development, several of which are associated with childhood fractures. Given the rise in obesity worldwide, it is of particular concern that excess fat accumulation during childhood appears to be a risk factor for fractures. Plausible explanations for this higher fracture risk include a greater propensity for falls, greater force generation upon fall impact, unhealthy lifestyle habits, and excessive adipose tissue that may have direct or indirect detrimental effects on skeletal development. To date, there remains little resolution or agreement about the impact of obesity and adiposity on skeletal development as well as the mechanisms underpinning these changes. Limitations of imaging modalities, short duration of follow-up in longitudinal studies, and differences among cohorts examined may all contribute to conflicting results. Nonetheless, a linear relationship between increasing adiposity and skeletal development seems unlikely. Fat mass may confer advantages to the developing cortical and trabecular bone compartments, provided that gains in fat mass are not excessive. However, when fat mass accumulation reaches excessive levels, unfavorable metabolic changes may impede skeletal development. Mechanisms underpinning these changes may relate to changes in the hormonal milieu, with adipokines potentially playing a central role, but again findings have been confounding. Changes in the relationship between fat and bone also appear to be age and sex dependent. Clearly, more work is needed to better understand the controversial impact of fat and obesity on skeletal development and fracture risk during childhood. PMID:28013362

The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children.

PubMed

Farr, Joshua N; Dimitri, Paul

2017-05-01

A complex interplay of genetic, environmental, hormonal, and behavioral factors affect skeletal development, several of which are associated with childhood fractures. Given the rise in obesity worldwide, it is of particular concern that excess fat accumulation during childhood appears to be a risk factor for fractures. Plausible explanations for this higher fracture risk include a greater propensity for falls, greater force generation upon fall impact, unhealthy lifestyle habits, and excessive adipose tissue that may have direct or indirect detrimental effects on skeletal development. To date, there remains little resolution or agreement about the impact of obesity and adiposity on skeletal development as well as the mechanisms underpinning these changes. Limitations of imaging modalities, short duration of follow-up in longitudinal studies, and differences among cohorts examined may all contribute to conflicting results. Nonetheless, a linear relationship between increasing adiposity and skeletal development seems unlikely. Fat mass may confer advantages to the developing cortical and trabecular bone compartments, provided that gains in fat mass are not excessive. However, when fat mass accumulation reaches excessive levels, unfavorable metabolic changes may impede skeletal development. Mechanisms underpinning these changes may relate to changes in the hormonal milieu, with adipokines potentially playing a central role, but again findings have been confounding. Changes in the relationship between fat and bone also appear to be age and sex dependent. Clearly, more work is needed to better understand the controversial impact of fat and obesity on skeletal development and fracture risk during childhood.

Thinking through health capacity development for Fragile States.

PubMed

Mark, Annabelle; Jones, Mike

2013-01-01

The purpose of this paper is to consider capacity development for healthcare in Fragile States and its roles, for example, in securing civil and political stability, as well as improved health, within the various contexts prevailing in fragile settings across the world. As a precursor to this, however, it is important to understand how, in rapidly changing environments, the role and contribution of different donors will have an impact in different ways. This paper sets out to interpret these issues, and what becomes apparent is the need to develop an understanding of the value base of donors, which we demonstrate through the development of a value-based framework. This highlights the separate motivations and choices made by donors, but what is apparent is that all remain within the positivist perspective perhaps for reasons of accountability and transparency. However, the emergence of new interpretations drawing on systems thinking, and followed by complexity theory more recently, in understanding contexts, suggests that the favouring of any one of these perspective can be counterproductive, without a consideration of the contexts in which they occur. In seeking an explanation of these environmental contexts, which also address the perspectives in use, we suggest the use of wider multi-ontology sense-making framework such as Cynefin. Through this approach, analytical insights can be given into the interpretation, decision and intervention processes available in these different and often changing environments, thus enabling greater coherence between donor values and recipient contexts. Copyright © 2012 John Wiley & Sons, Ltd.

NASA/GSFC Research Activities for the Global Ocean Carbon Cycle: A Prospectus for the 21st Century

NASA Technical Reports Server (NTRS)

Gregg, W. W.; Behrenfield, M. J.; Hoge, F. E.; Esaias, W. E.; Huang, N. E.; Long, S. R.; McClain, C. R.

2000-01-01

There are increasing concerns that anthropogenic inputs of carbon dioxide into the Earth system have the potential for climate change. In response to these concerns, the GSFC Laboratory for Hydrospheric Processes has formed the Ocean Carbon Science Team (OCST) to contribute to greater understanding of the global ocean carbon cycle. The overall goals of the OCST are to: 1) detect changes in biological components of the ocean carbon cycle through remote sensing of biooptical properties, 2) refine understanding of ocean carbon uptake and sequestration through application of basic research results, new satellite algorithms, and improved model parameterizations, 3) develop and implement new sensors providing critical missing environmental information related to the oceanic carbon cycle and the flux of CO2 across the air-sea interface. The specific objectives of the OCST are to: 1) establish a 20-year time series of ocean color, 2) develop new remote sensing technologies, 3) validate ocean remote sensing observations, 4) conduct ocean carbon cycle scientific investigations directly related to remote sensing data, emphasizing physiological, empirical and coupled physical/biological models, satellite algorithm development and improvement, and analysis of satellite data sets. These research and mission objectives are intended to improve our understanding of global ocean carbon cycling and contribute to national goals by maximizing the use of remote sensing data.

Predictors and Effects of Knowledge Management in U.S. Colleges and Schools of Pharmacy

NASA Astrophysics Data System (ADS)

Watcharadamrongkun, Suntaree

Public demands for accountability in higher education have placed increasing pressure on institutions to document their achievement of critical outcomes. These demands also have had wide-reaching implications for the development and enforcement of accreditation standards, including those governing pharmacy education. The knowledge management (KM) framework provides perspective for understanding how organizations evaluate themselves and guidance for how to improve their performance. In this study, we explore knowledge management processes, how these processes are affected by organizational structure and by information technology resources, and how these processes affect organizational performance. This is done in the context of Accreditation Standards and Guidelines for the Professional Program in Pharmacy Leading to the Doctor of Pharmacy Degree (Standards 2007). Data were collected using an online census survey of 121 U.S. Colleges and Schools of Pharmacy and supplemented with archival data. A key informant method was used with CEO Deans and Assessment leaders serving as respondents. The survey yielded a 76.0% (92/121) response rate. Exploratory factor analysis was used to construct scales (and scales) describing core KM processes: Knowledge Acquisition, Knowledge Integration, and Institutionalization; all scale reliabilities were found to be acceptable. Analysis showed that, as expected, greater Knowledge Acquisition predicts greater Knowledge Integration and greater Knowledge Integration predicts greater Institutionalization. Predictive models were constructed using hierarchical multiple regression and path analysis. Overall, information technology resources had stronger effects on KM processes than did characteristics of organizational structure. Greater Institutionalization predicted better outcomes related to direct measures of performance (i.e., NAPLEX pass rates, Accreditation actions) but Institutionalization was unrelated to an indirect measure of performance (i.e., USNWR ratings). Several organizational structure characteristics (i.e., size, age, and being part of an academic health center) were significant predictors of organizational performance; in contrast, IT resources had no direct effects on performance. Findings suggest that knowledge management processes, organizational structures and IT resources are related to better performance for Colleges and Schools of Pharmacy. Further research is needed to understand mechanisms through which specific knowledge management processes translate into better performance and, relatedly, to establish how enhancing KM processes can be used to improve institutional quality.

Allergic diseases and air pollution.

PubMed

Lee, Suh-Young; Chang, Yoon-Seok; Cho, Sang-Heon

2013-07-01

The prevalence of allergic diseases has been increasing rapidly, especially in developing countries. Various adverse health outcomes such as allergic disease can be attributed to rapidly increasing air pollution levels. Rapid urbanization and increased energy consumption worldwide have exposed the human body to not only increased quantities of ambient air pollution, but also a greater variety of pollutants. Many studies clearly demonstrate that air pollutants potently trigger asthma exacerbation. Evidence that transportation-related pollutants contribute to the development of allergies is also emerging. Moreover, exposure to particulate matter, ozone, and nitrogen dioxide contributes to the increased susceptibility to respiratory infections. This article focuses on the current understanding of the detrimental effects of air pollutants on allergic disease including exacerbation to the development of asthma, allergic rhinitis, and eczema as well as epigenetic regulation.

Engineering three-dimensional cardiac microtissues for potential drug screening applications.

PubMed

Wang, L; Huang, G; Sha, B; Wang, S; Han, Y L; Wu, J; Li, Y; Du, Y; Lu, T J; Xu, F

2014-01-01

Heart disease is one of the major global health issues. Despite rapid advances in cardiac tissue engineering, limited successful strategies have been achieved to cure cardiovascular diseases. This situation is mainly due to poor understanding of the mechanism of diverse heart diseases and unavailability of effective in vitro heart tissue models for cardiovascular drug screening. With the development of microengineering technologies, three-dimensional (3D) cardiac microtissue (CMT) models, mimicking 3D architectural microenvironment of native heart tissues, have been developed. The engineered 3D CMT models hold greater potential to be used for assessing effective drugs candidates than traditional two-dimensional cardiomyocyte culture models. This review discusses the development of 3D CMT models and highlights their potential applications for high-throughput screening of cardiovascular drug candidates.

Multiculturalism on Campus: Theory, Models, and Practices for Understanding Diversity and Creating Inclusion

ERIC Educational Resources Information Center

Cuyjet, Michael J., Ed.; Howard-Hamilton, Mary F., Ed.; Cooper, Diane L., Ed.

2011-01-01

As the diversity of the students on campus increases, the importance for everyone in authority to understand students' distinct cultures and how they perceive institutions, and equally, to understand their own privilege, and often unconscious cultural assumptions, has never been greater. This book presents a comprehensive set of resources to guide…

Land-use efficiency of big solar.

PubMed

Hernandez, Rebecca R; Hoffacker, Madison K; Field, Christopher B

2014-01-21

As utility-scale solar energy (USSE) systems increase in size and numbers globally, there is a growing interest in understanding environmental interactions between solar energy development and land-use decisions. Maximizing the efficient use of land for USSE is one of the major challenges in realizing the full potential of solar energy; however, the land-use efficiency (LUE; Wm(-2)) of USSE remains ambiguous. We quantified the capacity-based LUE of 183 USSE installations (>20 MW; planned, under construction, and operating) using California as a case study. In California, USSE installations are concentrated in the Central Valley and interior regions of southern California and have a LUE of 35.0 Wm(-2). The installations occupy approximately 86,000 ha and more land is allocated for photovoltaic schemes (72 294 ha) than for concentrating solar power (13,604 ha). Photovoltaic installations are greater in abundance (93%) than concentrating solar power, but technology type and nameplate capacity has no impact on capacity-based LUE. More USSE installations are on private land (80%) and have a significantly greater LUE (35.8 Wm(-2)) than installations on public land (25.4 Wm(-2)). Our findings can be used to better understand and improve the LUE of USSE, thereby maximizing economic, energetic, and environmental returns on investments.

Deepwater Program: Studies of Gulf of Mexico lower continental slope communities related to chemosynthetic and hard substrate habitats

USGS Publications Warehouse

Ross, Steve W.; Demopoulos, Amanda W.J.; Kellogg, Christina A.; Morrison, Cheryl L.; Nizinski, Martha S.; Ames, Cheryl L.; Casazza, Tara L.; Gualtieri, Daniel; Kovacs, Kaitlin; McClain, Jennifer P.; Quattrini, Andrea M.; Roa-Varon, Adela Y.; Thaler, Andrew D.

2012-01-01

This report summarizes research funded by the U.S. Geological Survey (USGS) in collaboration with the University of North Carolina at Wilmington (UNCW) on the ecology of deep chemosynthetic communities in the Gulf of Mexico. The research was conducted at the request of the U.S. Bureau of Ocean Energy Management, Regulation and Enforcement (BOEMRE; formerly Minerals Management Service) to complement a BOEMRE-funded project titled "Deepwater Program: Investigations of Chemosynthetic Communities on the Lower Continental Slope of the Gulf of Mexico." The overall research partnership, known as "Chemo III," was initiated to increase understanding of the distribution, structure, function, and vulnerabilities of these poorly known associations of animals and microbes for water depths greater than 1,000 meters (m) in the Gulf of Mexico. Chemosynthetic communities rely on carbon sources that are largely independent of sunlight and photosynthetic food webs. Despite recent research directed toward chemosynthetic and deep coral (for example, Lophelia pertusa) based ecosystems, these habitats are still poorly studied, especially at depths greater than 1,000 m. With the progression into deeper waters by fishing and energy industries, developing sufficient knowledge to manage these deep ecosystems is essential. Increased understanding of deep-sea communities will enable sound evaluations of potential impacts and appropriate mitigations.

Teaching health-care trainees empathy and homelessness IQ through service learning, reflective practice, and altruistic attribution.

PubMed

Chrisman-Khawam, Leanne; Abdullah, Neelab; Dhoopar, Arjun

2017-05-01

This article describes a novel inter-professional curriculum designed to address the needs of homeless patients in a Midwestern region of the United States which has high rates of poverty. The curriculum is intended for healthcare trainees coming from undergraduate pre-medical programs, nursing, pharmacy, social work, clinical psychology, medical school and post-graduate medical training in family medicine, medicine-pediatrics, and psychiatry. The clinical component is specifically designed to reach destitute patients and the curriculum is structured to reverse commonly held myths about homelessness among the trainees, thereby improving their Homelessness Information Quotient, the ability to more fully understand homelessness. Participants across all disciplines and specialties have shown greater empathy and helper behavior as determined by qualitative measures. Learners have also developed a greater understanding of health-care systems allowing them to more consistently address social determinants of health identified by the authors as their Disparity Information Quotient. This article outlines the process of initiating a homeless service program, a curriculum for addressing common myths about homelessness and the effective use of narrative methods, relational connections, and reflective practice to enable trainees to process their experience and decrease burnout by focusing on the value of altruism and finding meaning in their work.

Proteomic Analysis of Fetal Ovary Reveals That Ovarian Developmental Potential Is Greater in Meishan Pigs than in Yorkshire Pigs

PubMed Central

Che, Long; Wang, Dingyue; Yang, Zhenguo; Zhang, Pan; Lin, Yan; Fang, Zhengfeng; Che, Lianqiang; Li, Jian; Chen, Daiwen; Wu, De

2015-01-01

Time-dependent expression of functional proteins in fetal ovaries is important to understand the developmental process of the ovary. This study was carried out to enhance our understanding of the developmental process of porcine fetal ovaries and to better address the differences in fetal ovary development of local and foreign pigs. The objective of the present study is to test the expression of key proteins that regulate the growth and development of fetal ovaries in Meishan and Yorkshire porcine breeds by using proteomics technology. Six Meishan and 6 Yorkshire pregnant gilts were used in this experiment. Fetal ovaries were obtained from Yorkshire and Meishan gilts on days 55 and 90 of the gestation period. Using 2D-DIGE (two dimensional-difference in gel electrophoresis) analysis, the results showed that there are about 1551 and 1400 proteins in gilt fetal ovaries on days 55 and 90, respectively of the gestation. Using MALDI TOF-TOF MS analysis, 27 differentially expressed proteins were identified in the fetal ovaries of the 2 breeds on day 55 of gestation, and a total of 18 proteins were identified on day 90 of gestation. These differentially expressed proteins were involved in the regulation of biological processes (cell death, stress response, cytoskeletal proteins) and molecular functions (enzyme regulator activity). We also found that alpha-1-antitrypsin, actin, vimentin, and PP2A proteins promote the formation of primordial follicles in the ovaries of Yorkshire pigs on day 55 of gestation while low expression heat shock proteins and high expression alpha-fetoproteins (AFP) may promote Meishan fetal ovarian follicular development on day 90 of gestation. These findings provide a deeper understanding of how reduced expression of heat shock proteins and increased expression of AFP can significantly reduce the risk of reproductive disease in obese Meishan sows. Our study also shows how these proteins can increase the ovulation rate and may be responsible for the low reproductive efficiency reported in other obese breeds. The ovarian developmental potential was found to be greater in Meishan pigs than in Yorkshire pigs. PMID:26305539

Assessment of rail long-pitch corrugation

NASA Astrophysics Data System (ADS)

Valehrach, Jan; Guziur, Petr; Riha, Tomas; Plasek, Otto

2017-09-01

The paper focuses on defects of the running surface of the rail, namely the rail corrugation defect and specifically long-pitch corrugation in curves of small radii. These defects cause a shorter life of the rails, greater maintenance costs and increase the noise and vibration pollution. Therefore, it is very important to understand the formation and development of the imperfection of the rails. In the paper, various sections of railway tracks in the Czech Republic are listed, each of them completed with comparison of defect development, the particular track superstructure, rolling stock, axle load, traffic load etc. Based on performed measurements, defect development has been proved as different on sections with similar (or even same) parameters. The paper assumes that a train velocity is the significant circumstance for defect development rates. Assessment of track section with under sleeper pads, which are expected to be the one of the possible ways to suppress the corrugation defect development, is included in evaluation.

Greater sage-grouse: general use and roost site occurrence with pellet counts as a measure of relative abundance

Treesearch

Steven E. Hanser; Cameron L. Aldridge; Matthias Leu; Mary M. Rowland; Scott E. Nielsen; Steven T. Knick

2011-01-01

Greater sage-grouse (Centrocercus urophasianus) have been declining both spatially and numerically throughout their range because of anthropogenic disturbance and loss and fragmentation of sagebrush (Artemisia spp.) habitats. Understanding how sage-grouse respond to these habitat alterations and disturbances, particularly the...

Investigating Measurement Knowledge

ERIC Educational Resources Information Center

McCool, Jenni K.; Holland, Carol

2012-01-01

As teachers work to ensure that their students meet and exceed standards set by state and national governing bodies, the need for teacher support becomes greater and greater. Teachers, who play the most important role in a student's education, are faced with a classroom full of children who understand concepts on many different levels. To gain…

Legacy phosphorus in calcareous soils: effects of long-term poultry litter application

USDA-ARS?s Scientific Manuscript database

Sequential fractionation techniques, coupled with phosphatase hydrolysis, have allowed for greater understanding of manure/litter effects on soil P distribution. We evaluated the effect of long-term (greater than 10 years) poultry litter (broiler and turkey litter) application at annual rates of 4.5...

77 FR 16494 - Revised Public Utility Filing Requirements for Electric Quarterly Reports

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

... greater transparency in wholesale electricity markets through a greater understanding of these complex... simultaneous exchange transactions, which will bolster transparency in wholesale electricity markets by... counterparties in which party A sells an electricity product to party B at one location and party B sells a...

Facts and Faith: A Status Report on Youth Service.

ERIC Educational Resources Information Center

Lewis, Anne C.

Research supports the value of youth service, but indicates concerns about the diminishing interest of young people in giving of themselves. New justifications for community service include the following: (1) documentation of the educational value of service; (2) greater understanding of environmental and human needs; and (3) greater understanding…

Greater Phoenix Forward: Sustaining and Enhancing the Human-Services Infrastructure

ERIC Educational Resources Information Center

Morrison Institute for Public Policy, Arizona State University, 2008

2008-01-01

This report provides descriptive data for understanding the status of human services in Greater Phoenix, describes provocative issues that certain populations and providers face, and offers a starting point for determining Maricopa Valley's aspirations for tomorrow's human-services infrastructure. This report describes an array of populations that…

Antibiotics and the developing infant gut microbiota and resistome.

PubMed

Gibson, Molly K; Crofts, Terence S; Dantas, Gautam

2015-10-01

The microbial communities colonizing the human gut are tremendously diverse and highly personal. The composition and function of the microbiota play important roles in human health and disease, and considerable research has focused on understanding the ecological forces shaping these communities. While it is clear that factors such as diet, genotype of the host, and environment influence the adult gut microbiota community composition, recent work has emphasized the importance of early-life assembly dynamics in both the immediate and long-term personalized nature of the gut microbiota. While the mature adult gut microbiota is believed to be relatively stable, the developing infant gut microbiota (IGM) is highly dynamic and prone to disruption by external factors, including antibiotic exposure. Studies have revealed both transient and persistent alterations to the adult gut microbiota community resulting from antibiotic treatment later in life. As antibiotics are routinely prescribed at a greater rate in the first years of life, the impact of these interventions on the developing IGM is emerging as a key research priority. In addition to understanding the impact of these disruptions on the infant gut microbial architecture and related host diseases, we need to understand the contribution of early life antibiotics to the selection of antibiotic resistance gene reservoirs in the microbiota, and their threat to successful treatment of infectious disease. Here we review the current understanding of the developmental progression of the IGM and the impact of antibiotic therapies on its composition and encoded reservoir of antibiotic resistance genes. Copyright © 2015 Elsevier Ltd. All rights reserved.

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective.

PubMed

Pollard, C E; Valentin, J-P; Hammond, T G

2008-08-01

Drug-induced prolongation of the QT interval is having a significant impact on the ability of the pharmaceutical industry to develop new drugs. The development implications for a compound causing a significant effect in the 'Thorough QT/QTc Study' -- as defined in the clinical regulatory guidance (ICH E14) -- are substantial. In view of this, and the fact that QT interval prolongation is linked to direct inhibition of the hERG channel, in the early stages of drug discovery the focus is on testing for and screening out hERG activity. This has led to understanding of how to produce low potency hERG blockers whilst retaining desirable properties. Despite this, a number of factors mean that when an integrated risk assessment is generated towards the end of the discovery phase (by conducting at least an in vivo QT assessment) a QT interval prolongation risk is still often apparent; inhibition of hERG channel trafficking and partitioning into cardiac tissue are just two confounding factors. However, emerging information suggests that hERG safety margins have high predictive value and that when hERG and in vivo non-clinical data are combined, their predictive value to man, whilst not perfect, is >80%. Although understanding the anomalies is important and is being addressed, of greater importance is developing a better understanding of TdP, with the aim of being able to predict TdP rather than using an imperfect surrogate marker (QT interval prolongation). Without an understanding of how to predict TdP risk, high-benefit drugs for serious indications may never be marketed.

Self-management of gestational diabetes among Chinese migrants: A qualitative study.

PubMed

Wah, Yat Yin Eric; McGill, Margaret; Wong, Jencia; Ross, Glynis P; Harding, Anna-Jane; Krass, Ines

2018-04-21

Gestational diabetes mellitus is one of the most common complications of pregnancy. Women with Gestational diabetes are at increased risk of serious health outcomes, such as pre-eclampsia, obstructed labor, and the development of Type 2 diabetes later in life. Chinese migrants, the third largest cultural group in Australia, are more likely to develop Gestational diabetes than Australian-born women. However, to date, Gestational diabetes self-management has not been investigated in this population. To explore the understanding and self-management experiences of Gestational diabetes among Chinese migrants. Data were collected through individual semi-structured face-to-face interviews. Participants were recruited from the antenatal clinic at the Royal Prince Alfred Hospital. Interviews were audio-recorded, transcribed verbatim and thematically analyzed. Although the majority of participants demonstrated a good understanding of Gestational diabetes, some did not understand the principles behind healthcare advice and faced challenges in self-management. Confusion about self-monitoring of blood glucose and fear of insulin were also evident. Participants relied on both formal and informal sources of information. Some had difficulty obtaining adequate support. Cultural influences on self-management included meeting family needs, Chinese diet and use of Chinese medicines. To assist Chinese women with Gestational diabetes to better self-manage their condition, there is a need for clinicians to: (1) provide more effective diabetes education to ensure clear understanding of self-management principles; (2) actively elicit and respond to women's confusion and concerns; (3) provide women with adequate practical support; and (4) develop greater cultural awareness. Copyright © 2018 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

Using science to strengthen our Nation's resilience to tomorrow's challenges: understanding and preparing for coastal impacts

USGS Publications Warehouse

Simmons, Dale L.; Andersen, Matthew E.; Dean, Teresa A.; Focazio, Michael J.; Fulton, John W.; Haines, John W.; Mason, Jr., Robert R.; Tihansky, Ann B.; Young, John A.

2014-01-01

Hurricane Sandy caused unprecedented damage across some of the most densely populated coastal areas of the northeastern United States. The costly, landscape-altering destruction left in the wake of this storm is a stark reminder of our Nation’s need to become more resilient as we inevitably face future coastal hazards. As our Nation recovers from this devastating natural disaster, it is clear that accurate scientific information is essential as we seek to identify and develop strategies to address trends in coastal landscape change and reduce our future vulnerability to major storm events. To address this need, the U.S. Geological Survey (USGS) received $43.2 million in supplemental appropriations from the Department of the Interior (DOI) to conduct the scientific research needed to guide response, recovery, and rebuilding activities and to develop effective strategies for protecting coastal communities and resources in the future. This fact sheet describes how the USGS is combining interdisciplinary science with state-of-the-art technologies to achieve a comprehensive understanding of coastal change caused by Hurricane Sandy. By assessing coastal change impacts through research and by developing tools that enhance our science capabilities, support coastal stakeholders, and facilitate effective decision making, we continue to build a greater understanding of the processes at work across our Nation’s complex coastal environment—from wetlands, estuaries, barrier islands, and nearshore marine areas to infrastructure and human communities. This improved understanding will increase our resilience as we prepare for future short-term, extreme events as well as long-term coastal change.

STABLE ISOTOPIC EVIDENCE OF CARBON AND NITROGEN USE IN CULTURED ECTOMYCORRHIZAL AND SAPROTROPHIC FUNGI

EPA Science Inventory

Stable isotopes in sporocarps have proven useful for inferring ectomycorrhizal or saprotrophic status and understanding carbon (C) and nitrogen (N) utilization. However, greater understanding of processes producing isotopic concentrations is needed. We measured natural abundanc...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Todd M.; Benjamin, Jacob S.; Wright, Virginia L.

This paper will describe a practical methodology for understanding the cyber risk of a digital asset. This research attempts to gain a greater understanding of the cyber risk posed by a hardware-based computer asset by considering it as a sum of its hardware and software based sub-components.

The cost of a knowledge silo: a systematic re-review of water, sanitation and hygiene interventions.

PubMed

Loevinsohn, Michael; Mehta, Lyla; Cuming, Katie; Nicol, Alan; Cumming, Oliver; Ensink, Jeroen H J

2015-06-01

Divisions between communities, disciplinary and practice, impede understanding of how complex interventions in health and other sectors actually work and slow the development and spread of more effective ones. We test this hypothesis by re-reviewing a Cochrane-standard systematic review (SR) of water, sanitation and hygiene (WASH) interventions' impact on child diarrhoea morbidity: can greater understanding of impacts and how they are achieved be gained when the same papers are reviewed jointly from health and development perspectives? Using realist review methods, researchers examined the 27 papers for evidence of other impact pathways operating than assumed in the papers and SR. Evidence relating to four questions was judged on a scale of likelihood. At the 'more than possible' or 'likely' level, 22% of interventions were judged to involve substantially more actions than the SR's label indicated; 37% resulted in substantial additional impacts, beyond reduced diarrhoea morbidity; and unforeseen actions by individuals, households or communities substantially contributed to the impacts in 48% of studies. In 44%, it was judged that these additional impacts and actions would have substantially affected the intervention's effect on diarrhoea morbidity. The prevalence of these impacts and actions might well be found greater in studies not so narrowly selected. We identify six impact pathways suggested by these studies that were not considered by the SR: these are tentative, given the limitations of the literature we reviewed, but may help stimulate wider review and primary evaluation efforts. This re-review offers a fuller understanding of the impacts of these interventions and how they are produced, pointing to several ways in which investments might enhance health and wellbeing. It suggests that some conclusions of the SR and earlier reviews should be reconsidered. Moreover, it contributes important experience to the continuing debate on appropriate methods to evaluate and synthesize evidence on complex interventions. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2014; all rights reserved.

Planetary Atmosphere and Surfaces Chamber (PASC): A Platform to Address Various Challenges in Astrobiology

NASA Astrophysics Data System (ADS)

Mateo-Marti, Eva

2014-08-01

The study of planetary environments of astrobiological interest has become a major challenge. Because of the obvious technical and economical limitations on in situ planetary exploration, laboratory simulations are one of the most feasible research options to make advances both in planetary science and in developing a consistent description of the origin of life. With this objective in mind, we applied vacuum technology to the design of versatile vacuum chambers devoted to the simulation of planetary atmospheres' conditions. These vacuum chambers are able to simulate atmospheres and surface temperatures representative of the majority of planetary objects, and they are especially appropriate for studying the physical, chemical and biological changes induced in a particular sample by in situ irradiation or physical parameters in a controlled environment. Vacuum chambers are a promising potential tool in several scientific and technological fields, such as engineering, chemistry, geology and biology. They also offer the possibility of discriminating between the effects of individual physical parameters and selected combinations thereof. The implementation of our vacuum chambers in combination with analytical techniques was specifically developed to make feasible the in situ physico-chemical characterization of samples. Many wide-ranging applications in astrobiology are detailed herein to provide an understanding of the potential and flexibility of these experimental systems. Instruments and engineering technology for space applications could take advantage of our environment-simulation chambers for sensor calibration. Our systems also provide the opportunity to gain a greater understanding of the chemical reactivity of molecules on surfaces under different environments, thereby leading to a greater understanding of interface processes in prebiotic chemical reactions and facilitating studies of UV photostability and photochemistry on surfaces. Furthermore, the stability and presence of certain minerals on planetary surfaces and the potential habitability of microorganisms under various planetary environmental conditions can be studied using our apparatus. Therefore, these simulation chambers can address multiple different challenging and multidisciplinary astrobiological studies.

The cost of a knowledge silo: a systematic re-review of water, sanitation and hygiene interventions

PubMed Central

Loevinsohn, Michael; Mehta, Lyla; Cuming, Katie; Nicol, Alan; Cumming, Oliver; Ensink, Jeroen H J

2015-01-01

Divisions between communities, disciplinary and practice, impede understanding of how complex interventions in health and other sectors actually work and slow the development and spread of more effective ones. We test this hypothesis by re-reviewing a Cochrane-standard systematic review (SR) of water, sanitation and hygiene (WASH) interventions’ impact on child diarrhoea morbidity: can greater understanding of impacts and how they are achieved be gained when the same papers are reviewed jointly from health and development perspectives? Using realist review methods, researchers examined the 27 papers for evidence of other impact pathways operating than assumed in the papers and SR. Evidence relating to four questions was judged on a scale of likelihood. At the ‘more than possible’ or ‘likely’ level, 22% of interventions were judged to involve substantially more actions than the SR’s label indicated; 37% resulted in substantial additional impacts, beyond reduced diarrhoea morbidity; and unforeseen actions by individuals, households or communities substantially contributed to the impacts in 48% of studies. In 44%, it was judged that these additional impacts and actions would have substantially affected the intervention’s effect on diarrhoea morbidity. The prevalence of these impacts and actions might well be found greater in studies not so narrowly selected. We identify six impact pathways suggested by these studies that were not considered by the SR: these are tentative, given the limitations of the literature we reviewed, but may help stimulate wider review and primary evaluation efforts. This re-review offers a fuller understanding of the impacts of these interventions and how they are produced, pointing to several ways in which investments might enhance health and wellbeing. It suggests that some conclusions of the SR and earlier reviews should be reconsidered. Moreover, it contributes important experience to the continuing debate on appropriate methods to evaluate and synthesize evidence on complex interventions. PMID:24876076

Evaluating biomechanics of user-selected sitting and standing computer workstation.

PubMed

Lin, Michael Y; Barbir, Ana; Dennerlein, Jack T

2017-11-01

A standing computer workstation has now become a popular modern work place intervention to reduce sedentary behavior at work. However, user's interaction related to a standing computer workstation and its differences with a sitting workstation need to be understood to assist in developing recommendations for use and set up. The study compared the differences in upper extremity posture and muscle activity between user-selected sitting and standing workstation setups. Twenty participants (10 females, 10 males) volunteered for the study. 3-D posture, surface electromyography, and user-reported discomfort were measured while completing simulated tasks with each participant's self-selected workstation setups. Sitting computer workstation associated with more non-neutral shoulder postures and greater shoulder muscle activity, while standing computer workstation induced greater wrist adduction angle and greater extensor carpi radialis muscle activity. Sitting computer workstation also associated with greater shoulder abduction postural variation (90th-10th percentile) while standing computer workstation associated with greater variation for should rotation and wrist extension. Users reported similar overall discomfort levels within the first 10 min of work but had more than twice as much discomfort while standing than sitting after 45 min; with most discomfort reported in the low back for standing and shoulder for sitting. These different measures provide understanding in users' different interactions with sitting and standing and by alternating between the two configurations in short bouts may be a way of changing the loading pattern on the upper extremity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Modelling climate change and malaria transmission.

PubMed

Parham, Paul E; Michael, Edwin

2010-01-01

The impact of climate change on human health has received increasing attention in recent years, with potential impacts due to vector-borne diseases only now beginning to be understood. As the most severe vector-borne disease, with one million deaths globally in 2006, malaria is thought most likely to be affected by changes in climate variables due to the sensitivity of its transmission dynamics to environmental conditions. While considerable research has been carried out using statistical models to better assess the relationship between changes in environmental variables and malaria incidence, less progress has been made on developing process-based climate-driven mathematical models with greater explanatory power. Here, we develop a simple model of malaria transmission linked to climate which permits useful insights into the sensitivity of disease transmission to changes in rainfall and temperature variables. Both the impact of changes in the mean values of these key external variables and importantly temporal variation in these values are explored. We show that the development and analysis of such dynamic climate-driven transmission models will be crucial to understanding the rate at which P. falciparum and P. vivax may either infect, expand into or go extinct in populations as local environmental conditions change. Malaria becomes endemic in a population when the basic reproduction number R0 is greater than unity and we identify an optimum climate-driven transmission window for the disease, thus providing a useful indicator for determing how transmission risk may change as climate changes. Overall, our results indicate that considerable work is required to better understand ways in which global malaria incidence and distribution may alter with climate change. In particular, we show that the roles of seasonality, stochasticity and variability in environmental variables, as well as ultimately anthropogenic effects, require further study. The work presented here offers a theoretical framework upon which this future research may be developed.

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

PubMed Central

Santajit, Sirijan; Indrawattana, Nitaya

2016-01-01

The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are the leading cause of nosocomial infections throughout the world. Most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. Multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate use of antimicrobials, and substandard pharmaceuticals. Understanding the resistance mechanisms of these bacteria is crucial for the development of novel antimicrobial agents or other alternative tools to combat these public health challenges. Greater mechanistic understanding would also aid in the prediction of underlying or even unknown mechanisms of resistance, which could be applied to other emerging multidrug resistant pathogens. In this review, we summarize the known antimicrobial resistance mechanisms of ESKAPE pathogens. PMID:27274985

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens.

PubMed

Santajit, Sirijan; Indrawattana, Nitaya

2016-01-01

The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are the leading cause of nosocomial infections throughout the world. Most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. Multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate use of antimicrobials, and substandard pharmaceuticals. Understanding the resistance mechanisms of these bacteria is crucial for the development of novel antimicrobial agents or other alternative tools to combat these public health challenges. Greater mechanistic understanding would also aid in the prediction of underlying or even unknown mechanisms of resistance, which could be applied to other emerging multidrug resistant pathogens. In this review, we summarize the known antimicrobial resistance mechanisms of ESKAPE pathogens.

Socio-sexual functioning in autism spectrum disorder: A systematic review and meta-analyses of existing literature.

PubMed

Hancock, Grace I P; Stokes, Mark A; Mesibov, Gary B

2017-11-01

Socio-sexual functioning encompasses an individual's interests, behaviors, and knowledge with respect to sexual, romantic, and social aspects of life. An individual's understanding of these domains is developed through a range of informal and formal avenues of sexual health education. The current model demonstrated this and proposed that, compared to typically developing individuals, those with ASD develop socio-sexual functioning differently due to having less peer engagement, less relationship experience, more parental guidance, greater use of online materials, receive less school-based sexual health education, and more support from wellbeing services. Systematic review and meta-analysis of existing literature revealed that individuals with ASD have greater difficultly adhering to privacy norms, engage in less social behavior, are described as engaging in less appropriate sexual behavior, have greater concerns about themselves, and receive less sexual health education. Having fewer opportunities for appropriate informal and formal sexual health education leaves them at a double disadvantage from others who are receiving this information from both of these avenues. Some of the current meta-analytic results are cautioned by large l-square statistics which suggest that a degree of variance is being caused by extraneous factors. Further empirical research in this area is needed to overcome current design and sample limitations. Finally, the Sexual Behavior Scale was the most commonly utilized tool in the meta-analyzed studies, thus comprehensive evaluation of its functioning is warranted. The importance of work in this area is highlighted by the central role of social and sexual wellbeing on one's quality of life. Autism Res 2017, 10: 1823-1833. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Review of existing literature revealed that individuals with ASD have greater difficultly adhering to privacy norms, engage in less social behavior, are described as engaging in less appropriate sexual behavior, have greater concerns about themselves, and receive less sexual health education. Having fewer opportunities for appropriate informal and formal sexual health education leaves them at a double disadvantage from others who are receiving this information from both of these avenues. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Development and validation of a method for measuring depth of understanding in constructivist learning

NASA Astrophysics Data System (ADS)

Guarino, Lucia Falsetti

A method for measuring depth of understanding of students in the middle-level science classroom was developed and validated. A common theme in the literature on constructivism in science education is that constructivist pedagogy, as opposed to objectivist pedagogy, results in a greater depth of understanding. Since few instruments measuring this construct exist at the present time, the development of such a tool to measure this construct was a significant contribution to the current body of assessment technologies in science education. The author's Depth of Understanding Assessment (DUA) evolved from a writing measure originally designed as a history assessment. The study involved 230 eighth grade science students studying a chemical change unit. The main research questions were: (1) What is the relationship between the DUA and each of the following independent variables: recall, application, and questioning modalities as measured by the Cognitive Preference Test; deep, surface, achieving, and deep-achieving approaches as measured by the Learning Process Questionnaire; achievement as measured by the Chemical Change Quiz, and teacher perception of student ability to conceptualize science content? (2) Is there a difference in depth of understanding, as measured by the DUA, between students who are taught by objectivist pedagogy and students who are taught by constructivist pedagogy favoring the constructivist group? (3) Is there a gender difference in depth of understanding as measured by the DUA? (4) Do students who are taught by constructivist pedagogy perceive their learning environment as more constructivist than students who are taught by objectivist pedagogy? Six out of nine hypothesis tests supported the validity of the DUA. The results of the qualitative component of this study which consisted of student interviews substantiated the quantitative results by providing additional information and insights. There was a significant difference in depth of understanding between the two groups favoring the constructivist group, however, since only two teachers and their students participated in the study, the significance of this result is limited. There was a significant gender difference in depth of understanding favoring females. Students in the constructivist group perceived their learning environment to be more constructivist than students in the objectivist group.

Limited interface between physiotherapy primary care and people with severe mental illness: a qualitative study.

PubMed

Lee, Samantha; Waters, Flavie; Briffa, Kathy; Fary, Robyn E

2017-07-01

How do mental health professionals perceive the role of physiotherapists in the care of people with severe and persistent mental illness, and what factors do they perceive as influencing access to physiotherapy services? How do people with severe and persistent mental illness understand the potential role of physiotherapy in their healthcare, and what factors do they perceive as influencing access to physiotherapy services? Qualitative study. Twenty-four mental health professionals and 35 people with severe and persistent mental illness. Interview schedules were developed to explore participants' understanding of physiotherapy, as well as barriers and enablers to service access. Focus groups and interviews were conducted for each group of participants. Transcripts were analysed using an inductive approach to derive key themes. Both the mental health professionals and the people with severe and persistent mental illness expressed a limited understanding of the role and relevance of physiotherapy for physical health in mental healthcare. Common barriers to service access were cost, transport and lack of motivation. Likewise, enablers of reduced cost, provision of transport and education about physiotherapy to improve their understanding were identified. The health system structure and perceived lack of mental health knowledge by physiotherapists influenced referrals from mental health professionals. Consequently, education in mental health for physiotherapists and integration of the service within mental health were identified as potential enablers to physiotherapy access. Limited understanding about physiotherapy and its relevance to physical health in mental healthcare among mental health professionals and people with severe and persistent mental illness was found to be a key factor influencing service access. Limited physiotherapy presence and advocacy within mental health were also highlighted. There is a need for greater understanding about physiotherapy among stakeholders, and for physiotherapists to be well equipped with skills and knowledge in mental health to facilitate greater involvement. [Lee S, Waters F, Briffa K, Fary RE (2017) Limited interface between physiotherapy primary care and people with severe mental illness: a qualitative study. Journal of Physiotherapy 63: 168-174]. Copyright © 2017. Published by Elsevier B.V.

State of knowledge about energy development impacts on North American rangelands: An integrative approach.

PubMed

Kreuter, Urs P; Iwaasa, Alan D; Theodori, Gene L; Ansley, R James; Jackson, Robert B; Fraser, Lauchlan H; Naeth, M Anne; McGillivray, Susan; Moya, Edmundo Garcia

2016-09-15

To reduce dependence on foreign oil reserves, there has been a push in North America to develop alternative domestic energy resources. Relatively undeveloped renewable energy resources include biofuels and wind and solar energy, many of which occur predominantly on rangelands. Rangelands are also key areas for natural gas development from shales and tight sand formations. Accordingly, policies aimed at greater energy independence are likely to affect the delivery of crucial ecosystem services provided by rangelands. Assessing and dealing with the biophysical and socio-economic effects of energy development on rangeland ecosystems require an integrative and systematic approach that is predicated on a broad understanding of diverse issues related to energy development. In this article, we present a road map for developing an integrative assessment of energy development on rangelands in North America. We summarize current knowledge of socio-economic and biophysical aspects of rangeland based energy development, and we identify knowledge gaps and monitoring indicators to fill these knowledge gaps. Copyright © 2016 Elsevier Ltd. All rights reserved.

Decomposition of standing litter in arid grasslands: Interactions between sunlight, non-rainfall moisture, microbes, and plant traits

NASA Astrophysics Data System (ADS)

Logan, J. R. V.; Jacobson, P. J.; Jacobson, K. M.; Evans, S.

2017-12-01

Although arid lands make up 40% of the Earth's land surface, we still lack a strong understanding of carbon cycling and plant decomposition in these systems. One reason for this is that field studies typically only focus on decomposition at or below the ground surface even though standing dead litter (material that has not yet fallen to the ground) accounts for more than 50% of total necromass in many of these systems. While recent work has begun to recognize the important and unique aspects of standing litter decomposition, few studies have investigated specific mechanisms controlling rates of mass loss. We hypothesized that initial photodegradation of the outer plant cuticle of standing litter is an important determinant of litter decomposition because this process increases moisture absorption and subsequent opportunities for biological decomposition. Our preliminary results offer support for this hypothesis. We found that standing grass stems with their cuticles artificially removed had greater water absorbance and more than 400% greater mass loss over a 6-month period relative to controls with intact cuticles. Additionally, spectroscopic measurements of cuticle integrity showed damage to the litter surface after a period of extended photodegradation, allowing increased moisture uptake during simulated fog/dew events. These findings are especially important in the context of recent work by us and others showing that non-rainfall moisture (fog, dew, and water vapor) plays a much larger role in arid land decomposition than previously thought. Improving our understanding of the mechanisms driving decomposition of standing litter will enable us to develop a more predictive understanding of carbon storage in arid lands.

Improving medical students' understanding of prehospital care through a fourth year emergency medicine clerkship.

PubMed

Merlin, Mark A; Moon, Jeffery; Krimmel, Jessica; Liu, Junfeng; Marques-Baptista, Andreia

2010-02-01

The objective of this study was to survey medical students for a measurable opinion or knowledge increase in prehospital care after a fourth-year clerkship in emergency medicine (EM). The goal of the mandatory prehospital care aspect of the clerkship was twofold: to diminish the prehospital knowledge gap in medical school by teaching students about prehospital protocols and disaster medicine and to increase student interest. The study setting was within a university-based academic EM department with a prehospital system of 250 prehospital personnel. Data were collected from two similar questionnaires administered pre- and post-rotation to 49 fourth-year medical students. Statistical analyses were applied to collected data to quantify the changes of opinion and knowledge. Questions used a Likert five-point Scale. The data verified the improvement of students' knowledge in multiple areas of assessment. Greater than 35% opinion change (two points on the Likert Scale) was found in areas of prehospital care, 911 dispatch and education differences in prehospital providers (all p<0.0001; 95% CI 0.90 to 1.02, 0.66 to 0.90 and 0.66 to 0.90, respectively). Greater than 35% opinion change was also found in understanding triage (p=0.03; 95% CI 0.29 to 0.58) and general teaching of prehospital care, fellowship opportunities and use of a monitor/defibrillator (p<0.0001, p<0.0001 and p=0.04, respectively). We found medical students developed a significantly improved understanding of prehospital care. Without extraordinary effort, academic emergency departments could easily include a significant experience and education within fourth-year EM clerkships.

Effects of marital conflict on children: recent advances and emerging themes in process-oriented research.

PubMed

Cummings, E Mark; Davies, Patrick T

2002-01-01

The effects of marital conflict on children's adjustment are well documented. For the past decade research has increasingly focused on advancing a process-level understanding of these effects, that is, accounting for the particular responses and patterns embedded within specific contexts, histories, and developmental periods that account for children's outcomes over time. As a vehicle for presenting an update, this review follows the framework for process-oriented research initially proposed by Cummings and Cummings (1988), concentrating on recent research developments, and also considering new and emerging themes in this area of research. In this regard, areas of advancement include (a) greater articulation of the effects of specific context/stimulus characteristics of marital conflict, (b) progress in identifying the psychological response processes in children (e.g., cognitive, emotional, social, physiological) that are affected and their possible role in accounting for relations between marital conflict and child outcomes, (c) greater understanding of the role of child characteristics, family history, and other contextual factors, including effects on children due to interrelations between marital conflict and parenting, and (d) advances in the conceptualization of children's outcomes, including that effects may be more productively viewed as dynamic processes of functioning rather than simply clinical diagnoses. Understanding of the impact of marital conflict on children as a function of time-related processes remains a gap in a process-oriented conceptualization of effects. Based on this review, a revised model for a process-oriented approach on the effects of marital discord on children is proposed and suggestions are made for future research directions.

Chlamydia trachomatis today: treatment, detection, immunogenetics and the need for a greater global understanding of chlamydial disease pathogenesis

PubMed Central

Dean, Deborah

2012-01-01

Summary Chlamydia trachomatis is an important human pathogen causing a myriad of severe and debilitating diseases. While antibiotics have been a mainstay of treatment, there is increasing evidence for potential drug resistance, re-infection and persistent infections that require a reevaluation of treatment strategies. A critical need to address these issues will be a rapid, sensitive and cost-effect diagnostic that can be used for global screening, treatment and test-of-cure of infected individuals instead of empiric therapy that not only drives drug resistance but is not cost effective. This type of diagnostic would allow clinicians and researchers to evaluate the true incidence and prevalence of chlamydial infections in both developed and developing countries. There is extremely limited data on chlamydial sexually transmitted diseases (STD) in many developing countries including those in Central and South America. In addition, advancing our understanding of chlamydial disease pathogenesis will required an evaluation of host genetic susceptibility to infection and sequelae. We provide preliminary data on rates of chlamydial STDs and host genetic factors that predispose to infection among adolescent pregnant and non-pregnant commercial sex worker populations residing in Quito, Ecuador. PMID:20011691

The Intestinal Microbiome in Early Life: Health and Disease

PubMed Central

Arrieta, Marie-Claire; Stiemsma, Leah T.; Amenyogbe, Nelly; Brown, Eric M.; Finlay, Brett

2014-01-01

Human microbial colonization begins at birth and continues to develop and modulate in species abundance for about 3 years, until the microbiota becomes adult-like. During the same time period, children experience significant developmental changes that influence their health status as well as their immune system. An ever-expanding number of articles associate several diseases with early-life imbalances of the gut microbiota, also referred to as gut microbial dysbiosis. Whether early-life dysbiosis precedes and plays a role in disease pathogenesis, or simply originates from the disease process itself is a question that is beginning to be answered in a few diseases, including IBD, obesity, and asthma. This review describes the gut microbiome structure and function during the formative first years of life, as well as the environmental factors that determine its composition. It also aims to discuss the recent advances in understanding the role of the early-life gut microbiota in the development of immune-mediated, metabolic, and neurological diseases. A greater understanding of how the early-life gut microbiota impacts our immune development could potentially lead to novel microbial-derived therapies that target disease prevention at an early age. PMID:25250028

How Qualitative Methods Can be Used to Inform Model Development.

PubMed

Husbands, Samantha; Jowett, Susan; Barton, Pelham; Coast, Joanna

2017-06-01

Decision-analytic models play a key role in informing healthcare resource allocation decisions. However, there are ongoing concerns with the credibility of models. Modelling methods guidance can encourage good practice within model development, but its value is dependent on its ability to address the areas that modellers find most challenging. Further, it is important that modelling methods and related guidance are continually updated in light of any new approaches that could potentially enhance model credibility. The objective of this article was to highlight the ways in which qualitative methods have been used and recommended to inform decision-analytic model development and enhance modelling practices. With reference to the literature, the article discusses two key ways in which qualitative methods can be, and have been, applied. The first approach involves using qualitative methods to understand and inform general and future processes of model development, and the second, using qualitative techniques to directly inform the development of individual models. The literature suggests that qualitative methods can improve the validity and credibility of modelling processes by providing a means to understand existing modelling approaches that identifies where problems are occurring and further guidance is needed. It can also be applied within model development to facilitate the input of experts to structural development. We recommend that current and future model development would benefit from the greater integration of qualitative methods, specifically by studying 'real' modelling processes, and by developing recommendations around how qualitative methods can be adopted within everyday modelling practice.

Multi-Institutional, Multidisciplinary Study of the Impact of Course-Based Research Experiences†

PubMed Central

Mader, Catherine M.; Beck, Christopher W.; Grillo, Wendy H.; Hollowell, Gail P.; Hennington, Bettye S.; Staub, Nancy L.; Delesalle, Veronique A.; Lello, Denise; Merritt, Robert B.; Griffin, Gerald D.; Bradford, Chastity; Mao, Jinghe; Blumer, Lawrence S.; White, Sandra L.

2017-01-01

Numerous national reports have called for reforming laboratory courses so that all students experience the research process. In response, many course-based research experiences (CREs) have been developed and implemented. Research on the impact of these CREs suggests that student benefits can be similar to those of traditional apprentice-model research experiences. However, most assessments of CREs have been in individual courses at individual institutions or across institutions using the same CRE model. Furthermore, which structures and components of CREs result in the greatest student gains is unknown. We explored the impact of different CRE models in different contexts on student self-reported gains in understanding, skills, and professional development using the Classroom Undergraduate Research Experience (CURE) survey. Our analysis included 49 courses developed and taught at seven diverse institutions. Overall, students reported greater gains for all benefits when compared with the reported national means for the Survey of Undergraduate Research Experiences (SURE). Two aspects of these CREs were associated with greater student gains: 1) CREs that were the focus of the entire course or that more fully integrated modules within a traditional laboratory and 2) CREs that had a higher degree of student input and results that were unknown to both students and faculty. PMID:28861141

Multi-Institutional, Multidisciplinary Study of the Impact of Course-Based Research Experiences.

PubMed

Mader, Catherine M; Beck, Christopher W; Grillo, Wendy H; Hollowell, Gail P; Hennington, Bettye S; Staub, Nancy L; Delesalle, Veronique A; Lello, Denise; Merritt, Robert B; Griffin, Gerald D; Bradford, Chastity; Mao, Jinghe; Blumer, Lawrence S; White, Sandra L

2017-01-01

Numerous national reports have called for reforming laboratory courses so that all students experience the research process. In response, many course-based research experiences (CREs) have been developed and implemented. Research on the impact of these CREs suggests that student benefits can be similar to those of traditional apprentice-model research experiences. However, most assessments of CREs have been in individual courses at individual institutions or across institutions using the same CRE model. Furthermore, which structures and components of CREs result in the greatest student gains is unknown. We explored the impact of different CRE models in different contexts on student self-reported gains in understanding, skills, and professional development using the Classroom Undergraduate Research Experience (CURE) survey. Our analysis included 49 courses developed and taught at seven diverse institutions. Overall, students reported greater gains for all benefits when compared with the reported national means for the Survey of Undergraduate Research Experiences (SURE). Two aspects of these CREs were associated with greater student gains: 1) CREs that were the focus of the entire course or that more fully integrated modules within a traditional laboratory and 2) CREs that had a higher degree of student input and results that were unknown to both students and faculty.

Health and environmental policy issues in Canada: the role of watershed management in sustaining clean drinking water quality at surface sources.

PubMed

Davies, John-Mark; Mazumder, Asit

2003-07-01

Sustaining clean and safe drinking water sources is increasingly becoming a priority because of global pollution. The means of attaining and maintaining clean drinking water sources requires effective policies that identify, document, and reduce watershed risks. These risks are defined by their potential impact to human health. Health and risk are, therefore, indelibly linked because they are in part defined by each other. Understanding pathogen ecology and identifying watershed sources remains a priority because of the associated acute risks. Surface water quality changes resulting from inputs of human waste, nutrients and chemicals are associated with higher drinking water risks. Nutrient input can increase primary production and the resulting increase of organic matter results in greater disinfection by-product formation or requires greater treatment intensity. Many drinking water disease outbreaks have resulted from breaches in treatment facilities, therefore, even with greater treatment intensity poor source water quality intrinsically has greater associated health risks. Government and international agencies play a critical role in developing policy. The goal of maintaining water supplies whose availability is maximized and risks are minimized (i.e. sustainable) should be a vital part of such policy. Health risks are discussed in the context of a multi-barrier perspective and it is concluded that both passive (protection) and active (prescriptive management) management is necessary for sustainability. Canadian aboriginal water systems, British Columbian water policy and US EPA policies are given as examples. The basis for developing effective policies includes a strong reliance on sound science and effective instrumentation with careful consideration of stakeholders' interests. Only with such directed policies can the future availability of clean drinking water sources be ensured.

Greater Sage-Grouse National Research Strategy

USGS Publications Warehouse

Hanser, Steven E.; Manier, Daniel J.

2013-01-01

The condition of the sagebrush ecosystem has been declining in the Western United States, and greater sage-grouse (Centrocercus urophasianus), a sagebrush-obligate species, has experienced concurrent decreases in distribution and population numbers. This has prompted substantial research and management over the past two decades to improve the understanding of sage-grouse and its habitats and to address the observed decreases in distribution and population numbers. The amount of research and management has increased as the year 2015 approaches, which is when the U.S. Fish and Wildlife Service (FWS) is expected to make a final decision about whether or not to protect the species under the Endangered Species Act. In 2012, the Sage-Grouse Executive Oversight Committee (EOC) of the Western Association of Fish and Wildlife Agencies (WAFWA) requested that the U.S. Geological Survey (USGS) lead the development of a Greater Sage-Grouse National Research Strategy (hereafter Research Strategy). This request was motivated by a practical need to systematically connect existing research and conservation plans with persisting or emerging information needs. Managers and researchers also wanted to reduce redundancy and help focus limited funds on the highest priority research and management issues. The USGS undertook the development of this Research Strategy, which addresses information and science relating to the greater sage-grouse and its habitat across portions of 11 Western States. This Research Strategy provides an outline of important research topics to ensure that science information gaps are identified and documented in a comprehensive manner. Further, by identifying priority topics and critical information needed for planning, research, and resource management, it provides a structure to help coordinate members of an expansive research and management community in their efforts to conduct priority research.

Prediction of Postoperative Clinical Recovery of Drop Foot Attributable to Lumbar Degenerative Diseases, via a Bayesian Network.

PubMed

Takenaka, Shota; Aono, Hiroyuki

2017-03-01

Drop foot resulting from degenerative lumbar diseases can impair activities of daily living. Therefore, predictors of recovery of this symptom have been investigated using univariate or/and multivariate analyses. However, the conclusions have been somewhat controversial. Bayesian network models, which are graphic and intuitive to the clinician, may facilitate understanding of the prognosis of drop foot resulting from degenerative lumbar diseases. (1) To show a layered correlation among predictors of recovery from drop foot resulting from degenerative lumbar diseases; and (2) to develop support tools for clinical decisions to treat drop foot resulting from lumbar degenerative diseases. Between 1993 and 2013, we treated 141 patients with decompressive lumbar spine surgery who presented with drop foot attributable to degenerative diseases. Of those, 102 (72%) were included in this retrospective study because they had drop foot of recent development and had no diseases develop that affect evaluation of drop foot after surgery. Specifically, 28 (20%) patients could not be analyzed because their records were not available at a minimum of 2 years followup after surgery and 11 (8%) were lost owing to postoperative conditions that affect the muscle strength evaluation. Eight candidate variables were sex, age, herniated soft disc, duration of the neurologic injury (duration), preoperative tibialis anterior muscle strength (pretibialis anterior), leg pain, cauda equina syndrome, and number of involved levels. Manual muscle testing was used to assess the tibialis anterior muscle strength. Drop foot was defined as a tibialis anterior muscle strength score of less than 3 of 5 (5 = movement against gravity and full resistance, 4 = movement against gravity and moderate resistance, 3 = movement against gravity through full ROM, 3- = movement against gravity through partial ROM, 2 = movement with gravity eliminated through full ROM, 1 = slight contraction but no movement, and 0 = no contraction). The two outcomes of interest were postoperative tibialis anterior muscle strength (posttibialis anterior) of 3 or greater and posttibialis anterior strength of 4 or greater at 2 years after surgery. We developed two separate Bayesian network models with outcomes of interest for posttibialis anterior strength of 3 or greater and posttibialis anterior strength of 4 or greater. The two outcomes correspond to "good" and "excellent" results based on previous reports, respectively. Direct predictors are defined as variables that have the tail of the arrow connecting the outcome of interest, whereas indirect predictors are defined as variables that have the tail of the arrow connecting either direct predictors or other indirect predictors that have the tail of the arrow connecting direct predictors. Sevenfold cross validation and receiver-operating characteristic (ROC) curve analyses were performed to evaluate the accuracy and robustness of the Bayesian network models. Both of our Bayesian network models showed that weaker muscle power before surgery (pretibialis anterior ≤ 1) and longer duration of neurologic injury before treatment (> 30 days) were associated with a decreased likelihood of return of function by 2 years. The models for posttibialis anterior muscle strength of 3 or greater and posttibialis anterior muscle strength of 4 or greater were the same in terms of the graphs, showing that the two direct predictors were pretibialis anterior muscle strength (score ≤ 1 or ≥ 2) and duration (≤ 30 days or > 30 days). Age, herniated soft disc, and leg pain were identified as indirect predictors. We developed a decision-support tool in which the clinician can enter pretibialis anterior muscle strength and duration, and from this obtain the probability estimates of posttibialis anterior muscle strength. The probability estimates of posttibialis anterior muscle strength of 3 or greater and posttibialis anterior muscle strength of 4 or greater were 94% and 85%, respectively, in the most-favorable conditions (pretibialis anterior ≥ 2; duration ≤ 30 days) and 18% and 14%, respectively, in the least-favorable conditions (pretibialis anterior ≤ 1; duration > 30 days). On the sevenfold cross validation, the area under the ROC curve yielded means of 0.78 (95% CI, 0.68-0.87) and 0.74 (95% CI, 0.64-0.84) for posttibialis anterior muscle strength of 3 or greater and posttibialis anterior muscle strength of 4 or greater, respectively. The results of this study suggest that the clinician can understand intuitively the layered correlation among predictors by Bayesian network models. Based on the models, the decision-support tool successfully provided the probability estimates of posttibialis anterior muscle strength to treat drop foot attributable to lumbar degenerative diseases. These models were shown to be robust on the internal validation but should be externally validated in other populations. Level III, therapeutic study.

Geothermal prospection in the Greater Geneva Basin (Switzerland and France): Structural and reservoir quality assessment

NASA Astrophysics Data System (ADS)

Rusillon, Elme; Clerc, Nicolas; Makhloufi, Yasin; Brentini, Maud; Moscariello, Andrea

2017-04-01

A reservoir assessment was performed in the Greater Geneva Basin to evaluate the geothermal resources potential of low to medium enthalpy (Moscariello, 2016). For this purpose, a detail structural analysis of the basin was performed (Clerc et al., 2016) simultaneously with a reservoir appraisal study including petrophysical properties assessment in a consistent sedimentological and stratigraphical frame (Brentini et al., 2017). This multi-disciplinary study was organised in 4 steps: (1) investigation of the surrounding outcrops to understand the stratigraphy and lateral facies distribution of the sedimentary sequence from Permo-Carboniferous to Lower Cretaceous units; (2) development of 3D geological models derived from 2D seismic and well data focusing on the structural scheme of the basin to constrain better the tectonic influence on facies distribution and to assess potential hydraulic connectivity through faults between reservoir units ; (3) evaluation of the distribution, geometry, sedimentology and petrophysical properties of potential reservoir units from well data; (4) identification and selection of the most promising reservoir units for in-depth rock type characterization and 3D modeling. Petrophysical investigations revealed that the Kimmeridgian-Tithonian Reef Complex and the underlying Calcaires de Tabalcon units are the most promising geothermal reservoir targets (porosity range 10-20%; permeability to 1mD). Best reservoir properties are measured in patch reefs and high-energy peri-reefal depositional environments, which are surrounded by synchronous tight lagoonal deposits. Associated highly porous dolomitized intervals reported in the western part of the basin also provide enhanced reservoir quality. The distribution and geometry of best reservoir bodies is complex and constrained by (1) palaeotopography, which can be affected by synsedimentary fault activity during Mesozoic times, (2) sedimentary factors such as hydrodynamics, sea level variations, or sedimentation rates and (3) diagenetic history (Makhloufi et al., 2017). A detail structural characterization of the basin using 2D seismic data reveals the existence of several wrench fault zones and intra-basinal thrusts across the basin, which could act as hydraulic conduits and play a key role in connecting the most productive reservoir facies. To understand the propagation of these heterogeneous reservoirs, rock types are currently defined and will be integrated into 3D geological models. This integrated study allows us to understand better the distribution and properties of productive reservoir facies as well as hydraulic connectivity zones within the study area. This provides consistent knowledge for future geothermal exploration steps toward the successful development of this sustainable energy resource in the Greater Geneva Basin. Brentini et al. 2017 : Geothermal prospection in the Greater Geneva Basin: integration of geological data in the new Information System. Abstract, EGU General Assembly 2017, Vienna, Austria Clerc et al. 2016 : Structural Modeling of the Geneva Basin for Geothermal Ressource Assessment. Abstract, 14th Swiss Geoscience Meeting, Geneva, Switzerland Makhloufi et al. 2017 : Geothermal prospection in the Greater Geneva Basin (Switzerland and France) : impact of diagenesis on reservoir properties of the Upper Jurassic carbonate sediments. Abstract, EGU General Assembly 2017, Vienna, Austria Moscariello, A. 2016 : Geothermal exploration in SW Switzerland, Proceeding , European Geotermal Congress 2016, Strasbourg, France

High-Tech Versus High-Touch: Components of Hospital Costs Vary Widely.

PubMed

Song, Paula H; Reiter, Kristin L; Yi Xu, Wendy

The recent release by the Centers for Medicare & Medicaid Services of hospital charge and payment data to the public has renewed a national dialogue on hospital costs and prices. However, to better understand the driving force of hospital pricing and to develop strategies for controlling expenditures, it is important to understand the underlying costs of providing hospital services. We use Medicare Provider and Analysis Review inpatient claims data and Medicare cost report data for fiscal years 2008 and 2012 to examine variations in the contribution of "high-tech" resources (i.e., technology/medical device-intensive resources) versus "high-touch" resources (i.e., labor-intensive resources) to the total costs of providing two common services, as well as assess how these costs have changed over time. We found that high-tech inputs accounted for a greater proportion of the total costs of surgical service, whereas medical service costs were primarily attributable to high-touch inputs. Although the total costs of services did not change significantly over time, the distribution of high-tech, high-touch, and other costs for each service varied considerably across hospitals. Understanding resource inputs and the varying contribution of these inputs by clinical condition is an important first step in developing effective cost control strategies.

An Introduction to Teaching Moliere: "La Jalousie du Barbouille."

ERIC Educational Resources Information Center

Marzi, Jean-Denis

1984-01-01

Introduces a critical methodology for students approaching literary French texts of the Classical period, such as Moliere. Suggests that greater understanding of the material leads to greater enjoyment. It is concluded that this type of instruction need not be limited to students of French, but rather, students of all languages could profit from…

The Influence of Cross-Cultural Experiences & Location on Teachers' Perceptions of Cultural Competence

ERIC Educational Resources Information Center

Lopes-Murphy, Solange A.; Murphy, Christopher G.

2016-01-01

The increasing cultural and linguistic diversity in academic settings necessitates greater cultural competence on the part of teachers, and enhancing the cultural competence of teachers requires a greater understanding of both the level of cultural competence among teachers and the experiences that enhance cultural competence. Teacher educators…

Lek ecology of male greater sage-grouse in Carbon County, Wyoming

Treesearch

Aleshia Lynn Fremgen

2014-01-01

Greater sage-grouse (Centrocercus urophasianus, hereafter "sage-grouse") have experienced range-wide population declines for several decades, and as a result they were considered warranted for listing under the Endangered Species Act in 2010. Therefore, wildlife managers need to understand how sage-grouse breeding behavior influences long-term reproductive...

Helping Children Become More Knowledgeable through Text

ERIC Educational Resources Information Center

Neuman, Susan B.; Roskos, Kathleen

2012-01-01

With the adoption of the Common Core State Standards, curriculum resources are shifting from an emphasis on literary texts to a greater focus on informational texts. Although we need to understand the intention of these new Common Core State Standards, and the important drive toward greater content knowledge for all students, we must be wary of…

Understand and Advocate for Communities First

ERIC Educational Resources Information Center

Khalifa, Muhammad; Arnold, Noelle Witherspoon; Newcomb, Whitney

2015-01-01

Culturally responsive parent-school relationships require educators to consider the cultural practices and understandings of families as a necessary condition of greater academic achievement. The establishment of healthy parent-school relationships is a complex and dynamic process. A school-community overlap, with a priority given to community…

Units Matter

ERIC Educational Resources Information Center

I, Ji Yeong; Dougherty, Barbara J.; Berkaliev, Zaur

2015-01-01

Young children spend a much greater amount of time on practicing multiplication facts compared to understanding the concept of multiplication. When students have long-term, foundational concepts rather than a series of fragmented algorithms or facts, they are more likely to understand and generalize the mathematics. Using generalized models that…

How Community Colleges Understand the Scholarship of Teaching and Learning.

ERIC Educational Resources Information Center

Sperling, Charmian B.

2003-01-01

Describes the involvement of Middlesex Community College, Massachusetts, in the Carnegie Teaching Academy program. Faculty and staff at the college broadened their understanding of instructional pedagogy through greater appreciation of relevant connections between learning theory and classroom practice. Argues that faculty scholarship ultimately…

Bio-recognition and detection using liquid crystals.

PubMed

Hussain, A; Pina, A S; Roque, A C A

2009-09-15

Liquid crystals (LCs) are used extensively by the electronics industry as display devices. Advances in the understanding of the liquid crystalline phase and the chemistry therein lead to the development of LC exhibiting faster switching speed with greater twist angle. This in turn lead to the emergence of liquid crystal displays, rendering dial-and-needle based displays (such as those used in various meters) and cathode ray tubes obsolete. In this article, we review the history of LC and their emergence as an invaluable material for display devices and the more recent discovery of their use as sensing elements in biosensors. This new application of LC as tools in the development of fast and simple biosensors is envisaged to gain more importance in the foreseeable future.

The impact of "omic" and imaging technologies on assessing the host immune response to biodefence agents.

PubMed

Tree, Julia A; Flick-Smith, Helen; Elmore, Michael J; Rowland, Caroline A

2014-01-01

Understanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus, and Francisella tularensis. This review focuses on technological advances which allow this interaction to be studied in much greater detail. Namely, the use of "omic" technologies (next generation sequencing, DNA, and protein microarrays) for dissecting the underlying host response to infection at the molecular level; optical imaging techniques (flow cytometry and fluorescence microscopy) for assessing cellular responses to infection; and biophotonic imaging for visualising the infectious disease process. All of these technologies hold great promise for important breakthroughs in the rational development of vaccines and therapeutics for biodefence agents.

Cachexia.

PubMed

Graul, A I; Stringer, M; Sorbera, L

2016-09-01

Cachexia is a multiorgan, multifactorial and often irreversible wasting syndrome associated with cancer and other serious, chronic illnesses including AIDS, chronic heart failure, chronic kidney disease and chronic obstructive pulmonary disease. Treatment of the patient with cachexia is currently targeted to correcting the two underlying features of the condition: anorexia and metabolic disturbances. Greater understanding of the mechanisms behind cachexia and muscle wasting have led to new therapeutic possibilities, however. Several classes of drugs are under active development for cachexia including drugs acting on hormone receptors or cytokine receptors, myostatin/activin pathway antagonists, beta-adrenoceptor agonists and cannabinoids. This review will cover the pathophysiology, epidemiology, diagnosis, treatment, drug candidates under active development and targets for therapeutic intervention of cachexia. Copyright 2016 Prous Science, S.A.U. or its licensors. All rights reserved.

The use of poetry writing in nurse education: An evaluation.

PubMed

Jack, Kirsten

2015-09-01

Arts based approaches have been used in health education in various ways e.g. to develop emotional awareness, reduce anxiety and stress and assess communication skills. This evaluation aimed to explore the use of poetry writing as a way for undergraduate nursing students to consider their feelings about important practice issues. 42 first year undergraduate nursing students were asked to write a poem which focussed on an important nursing issue e.g. compassion, communication or the therapeutic role of the nurse. They were then asked to read the poem aloud to a small group and discuss its meaning. 60% (n=24) of students reported that the exercise had increased understanding of their chosen subject, 75% (n=30) stated that they had learned something about themselves and 65% (n=26) of students stated that they had enjoyed the poetry writing exercise. Qualitative comments suggested that the use of poetry enabled greater understanding of others' experiences, promoted open and honest reflection on feelings and supported the development of confidence. There is a need for teaching methods which engage and develop students' imagination, if they are going to be adequately prepared for the demands of nursing practice. Poetry writing and discussion supports the development of confidence, therapeutic communication skills and the ability to think creatively. Copyright © 2015 Elsevier Ltd. All rights reserved.

Diet and physical activity--interactions for health; public health nutrition in the European perspective.

PubMed

Sjöström, M; Yngve, A; Poortvliet, E; Warm, D; Ekelund, U

1999-09-01

For the majority of European adults, who neither smoke nor drink excessively, the most significant controllable risk factors affecting their long-term health are what they eat, and how physically active they are. Scientists are supposed to clarify to policy makers and health professionals the usefulness of their health messages. However, to be able to do that, a more detailed understanding is needed of the basic mechanisms behind the effects on health of diet and physical activity and, especially, the two in combination. Further, better methods for assessment of nutrition and physical activity in the population have to be developed, and more and better baseline data have to be collected. Increased and more efficient interventions are then needed. People trained and competent in the new discipline of Public Health Nutrition are required. Through the stimulating support that the European Commission, as well as other national and international partners, are presently giving to the development of Public Health Nutrition across Europe, we can hope for an increased mobility, networking and understanding between European nutrition and physical activity professionals. This will most likely result in greater and better policy making, strategy development, implementation and evaluation. We now have a great possibility to develop the integrated field of preventive nutrition and health enhancing physical activity.

Contrasting burnout, turnover intention, control, value congruence and knowledge sharing between Baby Boomers and Generation X.

PubMed

Leiter, Michael P; Jackson, Nicole J; Shaughnessy, Krystelle

2009-01-01

This paper examines the contrasting role of work values for nurses from two generations: Baby Boomers and Generation X. Differences among nurses regarding core values pertaining to their work has a potential to influence the quality of their work life. These differences may have implications for their vulnerability to job burnout. The analysis is based upon questionnaire surveys of nurses representing Generation X (n = 255) and Baby Boomers (n = 193) that contrasted their responses on job burnout, areas of work life, knowledge transfer and intention to quit. The analysis identified a greater person/organization value mismatch for Generation X nurses than for Baby Boomer nurses. Their greater value mismatch was associated with a greater susceptibility to burnout and a stronger intention to quit for Generation X nurses. The article notes the influence of Baby Boomer nurses in the structure of work and the application of new knowledge in health care work settings. Implications for recruitment and retention are discussed with a focus on knowledge transfer activities associated with distinct learning styles. Understanding value differences between generations will help nursing managers to develop more responsive work settings for nurses of all ages.

Behavioral and neural concordance in parent-child dyadic sleep patterns.

PubMed

Lee, Tae-Ho; Miernicki, Michelle E; Telzer, Eva H

2017-08-01

Sleep habits developed in adolescence shape long-term trajectories of psychological, educational, and physiological well-being. Adolescents' sleep behaviors are shaped by their parents' sleep at both the behavioral and biological levels. In the current study, we sought to examine how neural concordance in resting-state functional connectivity between parent-child dyads is associated with dyadic concordance in sleep duration and adolescents' sleep quality. To this end, we scanned both parents and their child (N=28 parent-child dyads; parent M age =42.8years; adolescent M age =14.9years; 14.3% father; 46.4% female adolescent) as they each underwent a resting-state scan. Using daily diaries, we also assessed dyadic concordance in sleep duration across two weeks. Our results show that greater daily concordance in sleep behavior is associated with greater neural concordance in default-mode network connectivity between parents and children. Moreover, greater neural and behavioral concordances in sleep is associated with more optimal sleep quality in adolescents. The current findings expand our understanding of dyadic concordance by providing a neurobiological mechanism by which parents and children share daily sleep behaviors. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

The boreal winter Madden-Julian Oscillation's influence on summertime precipitation in the greater Caribbean

NASA Astrophysics Data System (ADS)

Curtis, Scott; Gamble, Douglas W.

2016-07-01

Precipitation totals in the greater Caribbean are known to be affected by interannual variability. In particular, dry conditions in the spring-summer have been physically linked to the positive phase of North Atlantic Oscillation (NAO) in the literature. In this study, it was found through regression analysis that an active Madden-Julian Oscillation (MJO) in winter geographically focused over the Maritime Continent contributes to a positive NAO in March via the generation of Rossby waves in the Northern Hemisphere. Specifically, a negative Pacific-North American pattern develops in the winter and transitions to an Atlantic pattern in spring. The positive NAO is a transient feature of this evolving wave train, but a center of significant positive 200 hPa geopotential heights is entrenched over the southeast U.S. throughout the February to May time period and is manifested as high pressure at the surface. The southern flank of this system increases the speeds of the trade winds and leads to a cooling of the Caribbean sea surface temperatures and, thus, convection suppression and reduced precipitation. Thus, this study advances our understanding of the climate of the greater Caribbean by using climate teleconnections to relate the MJO to rainfall in the region.

The Benefits of Multilingualism to the Personal and Professional Development of Residents of The US.

PubMed

Kroll, Judith F; Dussias, Paola E

2017-01-01

In the past two decades, new research on multilingualism has changed our understanding of the consequences of learning and using two or more languages for cognition, for the brain, and for success and well-being across the entire lifespan. Far from the stereotype that exposure to multiple languages in infancy complicates language and cognitive development, the new findings suggest that individuals benefit from that exposure, with greater openness to other languages and to new learning itself. At the other end of the lifespan, in old age, the active use of two or more languages appears to provide protection against cognitive decline. That protection is seen in healthy aging and most dramatically in compensating for the symptoms of pathology in those who develop dementia or are recovering from stroke. In this article we briefly review the most exciting of these new research developments and consider their implications.

Limitations of the Millennium Development Goals: a literature review

PubMed Central

Fehling, Maya; Nelson, Brett D.; Venkatapuram, Sridhar

2013-01-01

With the Millennium Development Goals (MDGs) showing uneven progress, this review identifies possible limitations arising from the MDG framework itself rather than extrinsic issues. A multidisciplinary literature review was conducted with a focus on limitations in the formulation of the MDGs, their structure, content and implementation. Of 1837 MDG-related articles, 90 met criteria for analysis. Articles describe MDGs as being created by only a few stakeholders without adequate involvement by developing countries and overlooking development objectives previously agreed upon. Others claim MDGs are unachievable and simplistic, not adapted to national needs, do not specify accountable parties and reinforce vertical interventions. While MDGs have promoted increased health and well-being in many countries by recognising and deliberating on the possible constraints of the MDG framework, the post-2015 agenda may have even greater impact. Complex problems have simple, easy to understand, wrong answers (Henry Louis Mencken) PMID:24266508

Developmental biology of gut-probiotic interaction

PubMed Central

Patel, Ravi Mangal

2010-01-01

While our current knowledge of probiotic interaction in the developing gut remains poorly understood, emerging science is providing greater biological insight into their mechanism of action and therapeutic potential for human disease. Given their beneficial effects, probiotics remain promising agents in neonatal gastrointestinal disorders. Probiotics may restore or supply essential bacterial strains needed for gut maturation and homeostasis, particularly in hosts where this process has been disrupted. Here we highlight the unique characteristics of developing intestinal epithelia with a focus on gut development and colonization as well as the inflammatory propensity of immature epithelia. Additionally, we review potential mechanisms of beneficial probiotic interaction with immature intestinal epithelia including immunomodulation, upregulation of cytoprotective genes, prevention and regulation of apoptosis and maintenance of barrier function. Improved knowledge of gut-probiotic interaction in developing epithelia will allow for a better understanding of how probiotics exert their beneficial effects and help guide their therapeutic use. PMID:21327024

‘I'll be in a safe place’: a qualitative study of the decisions taken by people with advanced cancer to seek emergency department care

PubMed Central

Henson, Lesley A; Higginson, Irene J; Daveson, Barbara A; Ellis-Smith, Clare; Koffman, Jonathan; Morgan, Myfanwy; Gao, Wei

2016-01-01

Objective To explore the decisions of people with advanced cancer and their caregivers to seek emergency department (ED) care, and understand the issues that influence the decision-making process. Design Cross-sectional qualitative study incorporating semistructured patient and caregiver interviews. Methods Between December 2014 and July 2015, semistructured interviews were conducted with 18 people with advanced cancer, all of whom had recently attended the ED of a large university teaching hospital located in south-east London; and six of their caregivers. Interviews were audio recorded, transcribed verbatim and analysed using a constant comparative approach. Padgett and Brodsky's modified version of the ‘Behavioral Model of Health Services Use’ was used as a framework to guide the study. Results Issues influencing the decision-making process included: (1) disease-related anxiety—those with greater anxiety related to their cancer diagnosis interpreted their symptoms as more severe and/or requiring immediate attention; (2) prior patterns of health-seeking behaviour—at times of crisis participants defaulted to previously used services; (3) feelings of safety and familiarity with the hospital setting—many felt reassured by the presence of healthcare professionals and monitoring of their condition; and, (4) difficulties accessing community healthcare services—especially urgently and/or out-of-hours. Conclusions These data provide healthcare professionals and policymakers with a greater understanding of how systems of care may be developed to help reduce ED visits by people with advanced cancer. In particular, our findings suggest that the number of ED visits could be reduced with greater end-of-life symptom support and education, earlier collaboration between oncology and palliative care, and with increased access to community healthcare services. PMID:27807085

Gender differences in neural correlates of stress-induced anxiety.

PubMed

Seo, Dongju; Ahluwalia, Aneesha; Potenza, Marc N; Sinha, Rajita

2017-01-02

Although gender differences have been identified as a crucial factor for understanding stress-related anxiety and associated clinical disorders, the neural mechanisms underlying these differences remain unclear. To explore gender differences in the neural correlates of stress-induced anxiety, the current study used functional magnetic resonance imaging to examine brain responses in 96 healthy men and women with commensurable levels of trait anxiety as they engaged in a personalized guided imagery paradigm to provoke stress and neutral-relaxing experiences. During the task, a significant gender main effect emerged, with men displaying greater responses in the caudate, cingulate gyrus, midbrain, thalamus, and cerebellum. In contrast, women showed greater responses in the posterior insula, temporal gyrus, and occipital lobe. Additionally, a significant anxiety ratings × gender interaction from whole-brain regression analyses was observed in the dorsomedial prefrontal cortex, left inferior parietal lobe, left temporal gyrus, occipital gyrus, and cerebellum (P < 0.05, whole-brain family-wise error corrected), with positive associations between activity in these regions and stress-induced anxiety in women, but negative associations in men, indicating that men and women differentially use neural resources when experiencing stress-induced anxiety. The findings suggest that in response to stress, there is a greater use of the medial prefrontal-parietal cortices in experiencing subjective anxiety in women, while decreased use of this circuit was associated with increased subjective anxiety states in men. The current study has implications for understanding gender-specific differences in stress-induced anxiety and vulnerability to stress-related clinical disorders, and for developing more effective treatment strategies tailored to each gender. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Nurses' confidence in providing and managing care for older persons with depressive symptoms or depression in long-term care facilities: A national survey.

PubMed

Chuang, Yeu-Hui; Kuo, Li-Min

2018-05-24

The prevalence of depressive symptoms among older residents in long-term care facilities (LTCFs) is high. Nurses are the main healthcare providers in LTCFs and also the persons responsible for detecting changes in residents' mental function and providing subsequent care. Therefore, it is necessary to understand nurses' knowledge, attitudes, and confidence regarding care for older residents with depressive symptoms or depression. This study aimed to understand nurses' level of knowledge of late-life depression, attitudes towards depression, and confidence levels in caring for older adults with depressive symptoms or depression in LTCFs. A cross-sectional descriptive and correlational research design was used. A nationwide self-report survey was conducted in 2016. Ultimately, 556 valid questionnaires were returned. The study found that LTCF nurses' knowledge about late-life depression was poor, and they also lacked confidence in managing and caring for older persons with depressive symptoms or depression, but nurses' attitudes towards depression were neutral or slightly positive. Moreover, nurses who had greater confidence in providing care for older persons with depression were those with more positive attitudes towards depression, a greater interest level in taking care of older adults with depression, less late-life depression knowledge, longer nursing experience in LTCFs, and a greater interest level in late-life depression issues, and who had read late-life depression pamphlets or taken courses or classes in late-life depression. The findings suggest an urgent need to develop strategies to improve nurses' late-life depression knowledge and increase their confidence in providing care to older residents with depressive symptoms or depression. © 2018 Australian College of Mental Health Nurses Inc.

Bird productivity and nest predation in agricultural grasslands

USGS Publications Warehouse

Ribic, Christine; Guzy, Michael J.; Anderson, Travis J.; Sample, David W.; Nack, Jamie L.

2012-01-01

Effective conservation strategies for grassland birds in agricultural landscapes require understanding how nesting success varies among different grassland habitats. A key component to this is identifying nest predators and how these predators vary by habitat. We quantified nesting activity of obligate grassland birds in three habitats [remnant prairie, cool-season grass Conservation Reserve Program (CRP) fields, and pastures) in southwest Wisconsin, 2002-2004. We determined nest predators using video cameras and examined predator activity using track stations. Bobolink (Dolichonyx oryzivorus) and Henslow's Sparrow (Ammodramus henslowii) nested primarily in CRP fields, and Grasshopper Sparrow (A. savannarum) in remnant prairies. Eastern Meadowlark (Sturnella magna) nested evenly across all three habitats. Daily nest survival rate for Eastern Meadowlark varied by nesting stage alone. Daily nest survival rate for Grasshopper Sparrow varied by nest vegetation and distance to the nearest woody edge; nest survival was higher near woody edges. In CRP fields, most predators were grassland-associated, primarily thirteen-lined ground squirrels (Ictidomys tridecemlineatus). In pastures, one-third of the nest predators were grassland-associated (primarily thirteen-lined ground squirrels) and 56% were associated with woody habitats (primarily raccoons, Procyon lotor). Raccoon activity was greatest around pastures and lowest around prairies; regardless of habitat, raccoon activity along woody edges was twice that along non-woody edges. Thirteen-lined ground squirrel activity was greater along prairie edges than pastures and was greater along nonwoody edges compared to woody edges. In CRP fields, raccoon activity was greater along edges compared to the interiors; for ground squirrels these relationships were reversed. Using video camera technology to identify nest predators was indispensable in furthering our understanding of the grassland system. The challenge is to use that knowledge to develop management actions for both birds and predators.

Ovarian follicle dynamics of female Greater Scaup during egg production

USGS Publications Warehouse

Gorman, Kristen B.; Flint, Paul L.; Esler, Daniel N.; Williams, T.D.

2007-01-01

Studies of female waterfowl nutrient reserve use during egg production require a precise understanding of ovarian follicle dynamics to correctly interpret breeding status, and, therefore, derive proper inference. Concerns over numerical declines of North American scaup have increased the need to better understand the role of female condition in reproductive performance. We quantified ovarian follicle dynamics of female Greater Scaup (Aythya marila) breeding on the Yukon–Kuskokwim Delta, Alaska, using a method that accounts for within day variation in follicle size. We considered several models for describing changes in follicle growth with the best supported model estimating the duration of rapid follicle growth (RFG) to be 5.20 ± 0.52 days (±95% confidence intervals) for each developing follicle. Average diameter and dry mass of preovulatory follicles were estimated to be 9.36 mm and 0.26 g, respectively, at the onset of RFG, and these follicle characteristics were 41.47 mm and 15.57 g, respectively, at ovulation. The average diameter of postovulatory follicles immediately following ovulation was estimated to be 17.35 mm, regressing quickly over several days. In addition, we derived predictive equations using diameter and dry mass to estimate the number of days before, and after, ovulation for pre- and postovulatory follicles, as well as an equation to estimate dry mass of damaged follicles. Our results allow precise definition of RFG and nest initiation dates, clutch size, and the daily energetic and nutritional demands of egg production at the individual level. This study provides the necessary foundation for additional work on Greater Scaup reproductive energetics and physiology, and offers an approach for quantifying ovarian follicle dynamics in other species.

The influence of zero-hours contracts on care worker well-being.

PubMed

Ravalier, J M; Fidalgo, A R; Morton, R; Russell, L

2017-07-01

Care workers have an important social role which is set to expand with the increasing age of the UK population. However, the majority of care workers are employed on zero-hours contracts. Firstly, to investigate the relationship between working conditions and employee outcomes such as engagement and general mental well-being in a sample of UK care workers and management. Secondly, to assess whether the use of zero-hours contracts affects employee well-being. A cross-sectional survey of domiciliary care and care home employees, undertaken using the Management Standards Indicator Tool (MSIT), Utrecht Work Engagement Scale (UWES) and General Health Questionnaire (GHQ). T-tests and multivariate linear regression evaluated the differences in scoring between those with differing contractual conditions and job roles, and associations of MSIT scores with UWES and GHQ factors. Employee understanding of their role and job control were found to be priority areas for improvement in the sample. Similarly, care workers reported greater occupational demands and lower levels of control than management. However, while zero-hours contracts did not significantly influence employee well-being, these employees had greater levels of engagement in their jobs. Despite this, a greater proportion of individuals with zero-hours contracts had scores above accepted mental health cut-offs. Individual understanding of their role as care workers appears to play an important part in determining engagement and general mental well-being. However, more research is needed on the influence of zero-hours contracts on well-being, particularly in groups with increased likelihood of developing mental health disorders. © The Author 2017. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Comparison of environmental and egg microbiology associated with conventional and free-range laying hen management.

PubMed

Jones, D R; Anderson, K E; Musgrove, M T

2011-09-01

Eggs from alternative production practices are a growing niche in the market. Meeting consumer requests for greater diversity in retail egg options has resulted in some unique challenges such as understanding the food safety implications of eggs from alternative production practices. A study was conducted to determine what, if any, differences exist between nest run conventional cage-produced eggs and free range-produced eggs. A sister flock of brown egg layers was maintained in conventional cage and free-range production with egg and environmental sampling every 6 wk from 20 to 79 wk of age. Aerobic, coliform, and yeast and mold populations were monitored. Environmental microbial levels were not always indicative of egg contamination levels. When significant differences (P < 0.05 and P < 0.0001, dependent on season) were observed among treatments for coliforms, shell contamination levels of free-range nest box eggs and free-range floor eggs were always greater than those of conventional cage eggs, which remained low throughout the study (0.42-0.02 log cfu/mL). Shell yeast and mold levels were significantly greater in free-range floor eggs than in free-range nest box eggs and conventional cage eggs throughout the entire study. Egg contents contamination levels were extremely low for all monitored populations and treatments. Season of the year played a role in both environmental and egg microbial levels. Winter had the lowest levels of all populations monitored for all treatments, except for aerobic free-range floor egg shell emulsions, which were increased (3.6 log cfu/mL). Understanding the differences in microbial populations present on conventional cage-produced and free range-produced eggs can lead to the development of effective cleaning procedures, enhancing food safety.

Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex

PubMed Central

Groman, Stephanie M.; Jentsch, James D.; Leranth, Csaba; Redmond, D. Eugene; Kim, Jung D.; Diano, Sabrina; Roth, Robert H.

2015-01-01

Background: Cognitive deficits are a core symptom of schizophrenia, yet they remain particularly resistant to treatment. The model provided by repeatedly exposing adult nonhuman primates to phencyclidine has generated important insights into the neurobiology of these deficits, but it remains possible that administration of this psychotomimetic agent during the pre-adult period, when the dorsolateral prefrontal cortex in human and nonhuman primates is still undergoing significant maturation, may provide a greater understanding of schizophrenia-related cognitive deficits. Methods: The effects of repeated phencyclidine treatment on spine synapse number, dopamine turnover and BDNF expression in dorsolateral prefrontal cortex, and working memory accuracy were examined in pre-adult monkeys. Results: One week following phencyclidine treatment, juvenile and adolescent male monkeys demonstrated a greater loss of spine synapses in dorsolateral prefrontal cortex than adult male monkeys. Further studies indicated that in juvenile males, a cognitive deficit existed at 4 weeks following phencyclidine treatment, and this impairment was associated with decreased dopamine turnover, decreased brain derived neurotrophic factor messenger RNA, and a loss of dendritic spine synapses in dorsolateral prefrontal cortex. In contrast, female juvenile monkeys displayed no cognitive deficit at 4 weeks after phencyclidine treatment and no alteration in dopamine turnover or brain derived neurotrophic factor messenger RNA or spine synapse number in dorsolateral prefrontal cortex. In the combined group of male and female juvenile monkeys, significant linear correlations were detected between dopamine turnover, spine synapse number, and cognitive performance. Conclusions: As the incidence of schizophrenia is greater in males than females, these findings support the validity of the juvenile primate phencyclidine model and highlight its potential usefulness in understanding the deficits in dorsolateral prefrontal cortex in schizophrenia and developing novel treatments for the cognitive deficits associated with schizophrenia. PMID:25522392

Managing common marital stresses.

PubMed

Martin, A C; Starling, B P

1989-10-01

Marital conflict and divorce are problems of great magnitude in our society, and nurse practitioners are frequently asked by patients to address marital problems in clinical practice. "Family life cycle theory" provides a framework for understanding the common stresses of marital life and for developing nursing strategies to improve marital satisfaction. If unaddressed, marital difficulties have serious adverse consequences for a couple's health, leading to greater dysfunction and a decline in overall wellness. This article focuses on identifying couples in crisis, assisting them to achieve pre-crisis equilibrium or an even higher level of functioning, and providing appropriate referral if complex relationship problems exist.

Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer. | Office of Cancer Genomics

Cancer.gov

Body mass index (BMI) has been implicated as a primary factor influencing cancer development. However, understanding the relationship between these two complex traits has been confounded by both environmental and genetic heterogeneity. Analysis of QTL linked to tumorigenesis and BMI identified several loci associated with both phenotypes. Exploring these loci in greater detail revealed a novel relationship between the Pannexin 3 gene (Panx3) and both BMI and tumorigenesis. Panx3 is positively associated with BMI and is strongly tied to a lipid metabolism gene expression network.

Roads Investments, Spatial Intensification and Deforestation in the Brazilian Amazon

NASA Technical Reports Server (NTRS)

Pfaff, Alexander; Robalino, Juan; Walker, Robert; Aldrich, Steven; Caldas, Marcellus; Reis, Eustaquio; Perz, Stephen; Bohrer, Claudio; Arima, Eugenio; Laurance, William;

An historical context of modern principles in the management of intracranial injury from projectiles.

PubMed

Agarwalla, Pankaj K; Dunn, Gavin P; Laws, Edward R

2010-05-01

The contemporary management of projectile head injuries owes much to the lessons neurosurgeons have distilled from their experiences in war. Through early investigation and an increasingly detailed account of wartime clinical experience, neurosurgeons--including the field's early giants--began to gain a greater understanding not only of intracranial missile pathophysiology but also of appropriate management. In this paper, the authors trace the development of the principles of managing intracranial projectile injury from the Crimean War in the 19th century through the Vietnam War to provide a context that frames a summary of today's core management principles.

EVA Glove Research Team

NASA Technical Reports Server (NTRS)

Strauss, Alvin M.; Peterson, Steven W.; Main, John A.; Dickenson, Rueben D.; Shields, Bobby L.; Lorenz, Christine H.

1992-01-01

The goal of the basic research portion of the extravehicular activity (EVA) glove research program is to gain a greater understanding of the kinematics of the hand, the characteristics of the pressurized EVA glove, and the interaction of the two. Examination of the literature showed that there existed no acceptable, non-invasive method of obtaining accurate biomechanical data on the hand. For this reason a project was initiated to develop magnetic resonance imaging as a tool for biomechanical data acquisition and visualization. Literature reviews also revealed a lack of practical modeling methods for fabric structures, so a basic science research program was also initiated in this area.

Management of diabetes in South Asian communities in the UK.

PubMed

Hill, Jillian

This article discusses some of the specific challenges related to the management of diabetes in patients of South Asian origin. Communicating information that considers cultural, religious and language differences is important to promote effective self-management. The South Asian population in the UK is at greater risk of developing type 2 diabetes, and cultural practices such as fasting if not managed properly can lead to deterioration in their condition. The use of appropriate information and educators with Asian language skills and an understanding of the local population's culture are important to improve self-management of diabetes in these patients.

The Science of Computing: Expert Systems

NASA Technical Reports Server (NTRS)

Denning, Peter J.

1986-01-01

The creative urge of human beings is coupled with tremendous reverence for logic. The idea that the ability to reason logically--to be rational--is closely tied to intelligence was clear in the writings of Plato. The search for greater understanding of human intelligence led to the development of mathematical logic, the study of methods of proving the truth of statements by manipulating the symbols in which they are written without regard to the meanings of those symbols. By the nineteenth century a search was under way for a universal system of logic, one capable of proving anything provable in any other system.

Physics and the car business

NASA Astrophysics Data System (ADS)

Compton, W. Dale; Reitz, John R.

1981-01-01

Physicists have made important contributions to many areas of Ford Motor Company activity, particularly in areas of basic and applied research and product development. A number have assumed positions with management responsibility. Many of the technical problems facing the automotive industry today require a fundamental understanding, and the ability of physicists to contribute to the solution of these problems is greater now than it has been in the past. The present paper discusses some of these problems, and also traces a few case histories of physicists at Ford Motor Company; these illustrate the wide diversity of career paths for persons entering industry with a physics background.

An image-based approach to understanding the physics of MR artifacts.

PubMed

Morelli, John N; Runge, Val M; Ai, Fei; Attenberger, Ulrike; Vu, Lan; Schmeets, Stuart H; Nitz, Wolfgang R; Kirsch, John E

2011-01-01

As clinical magnetic resonance (MR) imaging becomes more versatile and more complex, it is increasingly difficult to develop and maintain a thorough understanding of the physical principles that govern the changing technology. This is particularly true for practicing radiologists, whose primary obligation is to interpret clinical images and not necessarily to understand complex equations describing the underlying physics. Nevertheless, the physics of MR imaging plays an important role in clinical practice because it determines image quality, and suboptimal image quality may hinder accurate diagnosis. This article provides an image-based explanation of the physics underlying common MR imaging artifacts, offering simple solutions for remedying each type of artifact. Solutions that have emerged from recent technologic advances with which radiologists may not yet be familiar are described in detail. Types of artifacts discussed include those resulting from voluntary and involuntary patient motion, magnetic susceptibility, magnetic field inhomogeneities, gradient nonlinearity, standing waves, aliasing, chemical shift, and signal truncation. With an improved awareness and understanding of these artifacts, radiologists will be better able to modify MR imaging protocols so as to optimize clinical image quality, allowing greater confidence in diagnosis. Copyright © RSNA, 2011.

Making Sense of the Brutality of the Holocaust: Critical Themes and New Perspectives.

PubMed

Miller, Eric D

2017-01-02

This article offers an analytic, integrative review of select themes associated with one of history's greatest atrocities: the Holocaust. Much of this review considers general and Holocaust-specific themes as they pertain to the nature of senseless violence and evil. The importance of having a greater understanding of the sheer brutality of violence perpetuated in the Holocaust is emphasized. As part of this discussion, considerable attention is given to how Internet-based photographs and videos from the Holocaust era can provide greater insight into understanding the evil associated with this genocide. Some consideration of the larger meaning of the Holocaust, particularly for Jews, is also examined.

Local sustainability and gender ratio: evaluating the impacts of mining and tourism on sustainable development in Yunnan, China.

PubMed

Huang, Ganlin; Ali, Saleem

2015-01-19

This study employed rapid evaluation methods to investigate how the leading industries of mining and tourism impact sustainability as manifest through social, economic and environmental dimensions in Yunnan, China. Within the social context, we also consider the differentiated impact on gender ratio-which is a salient feature of sustained development trajectories. Our results indicate that mining areas performed better than tourism areas in economic aspects but fell behind in social development, especially regarding the issue of gender balance. Conclusions on environmental status cannot be drawn due to a lack of data.  The results from the environmental indicators are mixed. Our study demonstrates that rapid evaluation using currently available data can provide a means of greater understanding regarding local sustainability and highlights areas that need attention from policy makers, agencies and academia.

Comparing the development of the multiplication of fractions in Turkish and American textbooks

NASA Astrophysics Data System (ADS)

Kar, Tuğrul; Güler, Gürsel; Şen, Ceylan; Özdemir, Ercan

2018-02-01

This study analyzed the methods used to teach the multiplication of fractions in Turkish and American textbooks. Two Turkish textbooks and two American textbooks, Everyday Mathematics (EM) and Connected Mathematics 3 (CM), were analyzed. The analyses focused on the content and the nature of the mathematical problems presented in the textbooks. The findings of the study showed that the American textbooks aimed at developing conceptual understanding first and then procedural fluency, whereas the Turkish textbooks aimed at developing both concurrently. The American textbooks provided more opportunities for different computational strategies. The solutions to most problems in all textbooks required a single computational step, a numerical answer, and procedural knowledge. Furthermore, compared with the Turkish textbooks, the American textbooks contained a greater number of problems that required high-level cognitive skills such as mathematical reasoning.

Pharmacological treatment of anxiety disorders: Current treatments and future directions✩

PubMed Central

Farach, Frank J.; Pruitt, Larry D.; Jun, Janie J.; Jerud, Alissa B.; Zoellner, Lori A.; Roy-Byrne, Peter P.

2012-01-01

Modern pharmacological treatments for anxiety disorders are safer and more tolerable than they were 30 years ago. Unfortunately, treatment efficacy and duration have not improved in most cases despite a greater understanding of the pathophysiology of anxiety. Moreover, innovative treatments have not reached the market despite billions of research dollars invested in drug development. In reviewing the literature on current treatments, we argue that evidence-based practice would benefit from better research on the causes of incomplete treatment response as well as the comparative efficacy of drug combinations and sequencing. We also survey two broad approaches to the development of innovative anxiety treatments: the continued development of drugs based on specific neuroreceptors and the pharmacological manipulation of fear-related memory. We highlight directions for future research, as neither of these approaches is ready for routine clinical use. PMID:23023162

Beyond simple small-angle X-ray scattering: developments in online complementary techniques and sample environments.

PubMed

Bras, Wim; Koizumi, Satoshi; Terrill, Nicholas J

2014-11-01

Small- and wide-angle X-ray scattering (SAXS, WAXS) are standard tools in materials research. The simultaneous measurement of SAXS and WAXS data in time-resolved studies has gained popularity due to the complementary information obtained. Furthermore, the combination of these data with non X-ray based techniques, via either simultaneous or independent measurements, has advanced understanding of the driving forces that lead to the structures and morphologies of materials, which in turn give rise to their properties. The simultaneous measurement of different data regimes and types, using either X-rays or neutrons, and the desire to control parameters that initiate and control structural changes have led to greater demands on sample environments. Examples of developments in technique combinations and sample environment design are discussed, together with a brief speculation about promising future developments.

Beyond simple small-angle X-ray scattering: developments in online complementary techniques and sample environments

PubMed Central

Bras, Wim; Koizumi, Satoshi; Terrill, Nicholas J

2014-01-01

Small- and wide-angle X-ray scattering (SAXS, WAXS) are standard tools in materials research. The simultaneous measurement of SAXS and WAXS data in time-resolved studies has gained popularity due to the complementary information obtained. Furthermore, the combination of these data with non X-ray based techniques, via either simultaneous or independent measurements, has advanced understanding of the driving forces that lead to the structures and morphologies of materials, which in turn give rise to their properties. The simultaneous measurement of different data regimes and types, using either X-rays or neutrons, and the desire to control parameters that initiate and control structural changes have led to greater demands on sample environments. Examples of developments in technique combinations and sample environment design are discussed, together with a brief speculation about promising future developments. PMID:25485128

36 CFR 1250.60 - How will NARA determine if I am eligible for a fee waiver for NARA operational records?

Code of Federal Regulations, 2010 CFR

2010-07-01

... advance the understanding of the general public on the issue? (4) Do you have expertise in or a thorough understanding of these records? (5) Will you be able to disseminate this information to a broad spectrum of the public? (6) Will disclosure lead to a significantly greater understanding of the Government by the public...

Development of an Open-Path N2O Flux Measurement System for Understanding Agricultural and Soil Emissions

NASA Astrophysics Data System (ADS)

Gomez, A.; Silver, J.; Massick, S.; Ochoa, E.; Stanton, A. C.

2015-12-01

Nitrous oxide is the third most important greenhouse gas, with an atmospheric lifetime of ~114 years and a global warming impact ~300 times greater than that of CO2. The main cause of nitrous oxide's atmospheric increase is anthropogenic emissions, and over 80% of the current global anthropogenic flux is related to agriculture, including associated land-use change. An accurate assessment of N2O emissions from agriculture is vital not only for understanding the global N2O balance and its impact on climate and also for designing crop systems with lower GHG emissions. This work focuses on the early development of an open path N2O instrument for field deployment, based on quantum cascade laser absorption. With a targeted precision of 0.1 ppb at 10 Hz, this instrument will enable eddy covariance measurements to determine vertical fluxes of N2O. Details of the instrument design, which emphasizes ruggedness and high thermal stability, will be presented along with initial results from outdoor testing of the instrument.

How getting noticed helps getting on: successful attention capture doubles children's cooperative play

PubMed Central

Yuill, Nicola; Hinske, Steve; Williams, Sophie E.; Leith, Georgia

2014-01-01

Cooperative social interaction is a complex skill that involves maintaining shared attention and continually negotiating a common frame of reference. Privileged in human evolution, cooperation provides support for the development of social-cognitive skills. We hypothesize that providing audio support for capturing playmates' attention will increase cooperative play in groups of young children. Attention capture was manipulated via an audio-augmented toy to boost children's attention bids. Study 1 (48 6- to 11-year-olds) showed that the augmented toy yielded significantly more cooperative play in triads compared to the same toy without augmentation. In Study 2 (33 7- to 9-year-olds) the augmented toy supported greater success of attention bids, which were associated with longer cooperative play, associated in turn with better group narratives. The results show how cooperation requires moment-by-moment coordination of attention and how we can manipulate environments to reveal and support mechanisms of social interaction. Our findings have implications for understanding the role of joint attention in the development of cooperative action and shared understanding. PMID:24904453

Construction of a model demonstrating neural pathways and reflex arcs.

PubMed

Chan, V; Pisegna, J M; Rosian, R L; DiCarlo, S E

1996-12-01

Employment opportunities in the future will require higher skills and an understanding of mathematics and science. As a result of the growing number of careers that require solid science and mathematics training, the methods of science education are undergoing major reform. To adequately equip students for technologically advanced positions, new teaching methods must be developed that prepare tomorrow's workforce for the challenges of the 21st century. One such method is the use of models. By actively building and manipulating concrete models that represent scientific concepts, students are involved in the most basic level of Piaget's learning scheme: the sensorimotor stage. Models are useful in reaching all students at the foundational levels of learning, and further learning experiences are rapidly moved through higher learning levels. This success ensures greater comprehension and understanding compared with the traditional methods of rote memorization. We developed an exercise for the construction of an inexpensive, easy-to-build model demonstrating neural pathways and reflex arcs. Our exercise also includes many supplemental teaching tools. The exercise is designed to fulfill the need of sound physiological teaching materials for high school students.

Quantifying long-term trajectories of plant community change with movement models: implication for ecological resilience

USDA-ARS?s Scientific Manuscript database

Quantification of rates and patterns of community dynamics is central for understanding the organization and function of ecosystems. These insights may support a greater empirical understanding of ecological resilience, and the application of resilience concepts toward ecosystem management. Distinct...

Prospective Teachers' Understandings: Function and Composite Function.

ERIC Educational Resources Information Center

Meel, David E.

2003-01-01

The current education reform efforts place greater emphasis on conceptual understanding and focus attention on teacher preparation, especially on the adequacy of teachers' mathematical knowledge of the material they will be teaching. This paper discusses the responses of 20 prospective elementary and special education mathematics specialists to…

Cross-Curricular Science and History

ERIC Educational Resources Information Center

Byrne, Eleanor

2011-01-01

Cross-curricular teaching and learning can be an approach that not only looks to amalgamate subjects together for the sake of greater understanding of each individual subject, but also to make meaningful connections between subjects based on disciplinary similarities. This involves a deeper understanding of each subject's specific characteristics…

STEM development: A study of 6th--12th grade girls' interest and confidence in mathematics and science

NASA Astrophysics Data System (ADS)

Heaverlo, Carol Ann

Researchers, policymakers, business, and industry have indicated that the United States will experience a shortage of professionals in the Science, Technology, Engineering, and Mathematics (STEM) fields. Several strategies have been suggested to address this shortage, one of which includes increasing the representation of girls and women in the STEM fields. In order to increase the representation of women in the STEM fields, it is important to understand the developmental factors that impact girls' interest and confidence in STEM academics and extracurricular programs. Research indicates that greater confidence leads to greater interest and vice versa (Denissen et al., 2007). This study identifies factors that impact girls' interest and confidence in mathematics and science, defined as girls' STEM development. Using Bronfenbrenner's (2005) bioecological model of human development, several factors were hypothesized as having an impact on girls' STEM development; specifically, the macrosystems of region of residence and race/ethnicity, and the microsystems of extracurricular STEM activities, family STEM influence, and math/science teacher influence. Hierarchical regression analysis results indicated that extracurricular STEM involvement and math teacher influence were statistically significant predictors for 6--12th grade girls' interest and confidence in mathematics. Furthermore, hierarchical regression analysis results indicated that the only significant predictor for 6--12th grade girls' interest and confidence in science was science teacher influence. This study provides new knowledge about the factors that impact girls' STEM development. Results can be used to inform and guide educators, administrators, and policy makers in developing programs and policy that support and encourage the STEM development of 6--12th grade girls.

Update on the key developments of the neurologic complications in children infected with HIV.

PubMed

Wilmshurst, Jo M; Donald, Kirsten A; Eley, Brian

2014-11-01

To discuss recent research findings of neurologic complications in HIV-infected children, specifically addressing neuroinfections, cerebrovascular disease, epilepsy and neurocognitive complications. The range of neurologic childhood onset complications is diverse and often overlaps diseases previously considered only to manifest in adults. In the pediatric population, these complications frequently have their own unique disease identity, which may be related to maturational patterns evident in the developing brain. Developments regarding the pathogenesis of neuroAIDS, treatment of tuberculous meningitis and prevention of bacterial meningitis are described. With the advent of neuroimaging, there is greater insight into silent cerebrovascular events and the progression of vasculopathy in HIV-infected children. The role of surgical intervention for affected cases is a novel area that could alter the otherwise poor prognosis. Epilepsy, although common as a burden of disease, carries its own additional complications with regard to cross reactivity with various antiretroviral therapies. Increased risk of low bone mineral density supports a role for supplementation with vitamin D in people receiving antiretroviral therapy and antiepileptic drugs. Recognition of the early neurobiological, as well as spectrum of neurocognitive effects of the HIV on the developing brain, is evolving, as greater numbers of children are treated early. Developments in these critical areas are described. Recent research reflects the need for improved strategies to prevent neuroinfections, more effective screening and interventions for vasculopathy and better antiepileptic drugs for HIV-infected children. Furthermore, our understanding of the timing and spectrum of neurocognitive complications is evolving.

Epistemic Beliefs and Conceptual Understanding in Biotechnology: A Case Study

NASA Astrophysics Data System (ADS)

Rebello, Carina M.; Siegel, Marcelle A.; Witzig, Stephen B.; Freyermuth, Sharyn K.; McClure, Bruce A.

2012-04-01

The purpose of this investigation was to explore students' epistemic beliefs and conceptual understanding of biotechnology. Epistemic beliefs can influence reasoning, how individuals evaluate information, and informed decision making abilities. These skills are important for an informed citizenry that will participate in debates regarding areas in science such as biotechnology. We report on an in-depth case study analysis of three undergraduate, non-science majors in a biotechnology course designed for non-biochemistry majors. We selected participants who performed above average and below average on the first in-class exam. Data from multiple sources—interviews, exams, and a concept instrument—were used to construct (a) individual profiles and (b) a cross-case analysis of our participants' conceptual development and epistemic beliefs from two different theoretical perspectives—Women's Ways of Knowing and the Reflective Judgment Model. Two independent trained researchers coded all case records independently for both theoretical perspectives, with resultant initial Cohen's kappa values above .715 (substantial agreement), and then reached consensus on the codes. Results indicate that a student with more sophisticated epistemology demonstrated greater conceptual understandings at the end of the course than a student with less sophisticated epistemology, even though the latter performed higher initially. Also a student with a less sophisticated epistemology and low initial conceptual performance does not demonstrate gains in their overall conceptual understanding. Results suggest the need for instructional interventions fostering epistemological development of learners in order to facilitate their conceptual growth.

Innovations in air sampling to detect plant pathogens

PubMed Central

West, JS; Kimber, RBE

2015-01-01

Many innovations in the development and use of air sampling devices have occurred in plant pathology since the first description of the Hirst spore trap. These include improvements in capture efficiency at relatively high air-volume collection rates, methods to enhance the ease of sample processing with downstream diagnostic methods and even full automation of sampling, diagnosis and wireless reporting of results. Other innovations have been to mount air samplers on mobile platforms such as UAVs and ground vehicles to allow sampling at different altitudes and locations in a short space of time to identify potential sources and population structure. Geographical Information Systems and the application to a network of samplers can allow a greater prediction of airborne inoculum and dispersal dynamics. This field of technology is now developing quickly as novel diagnostic methods allow increasingly rapid and accurate quantifications of airborne species and genetic traits. Sampling and interpretation of results, particularly action-thresholds, is improved by understanding components of air dispersal and dilution processes and can add greater precision in the application of crop protection products as part of integrated pest and disease management decisions. The applications of air samplers are likely to increase, with much greater adoption by growers or industry support workers to aid in crop protection decisions. The same devices are likely to improve information available for detection of allergens causing hay fever and asthma or provide valuable metadata for regional plant disease dynamics. PMID:25745191

Translational models of lung disease.

PubMed

Mercer, Paul F; Abbott-Banner, Katharine; Adcock, Ian M; Knowles, Richard G

2015-02-01

The 2nd Cross Company Respiratory Symposium (CCRS), held in Horsham, U.K. in 2012, brought together representatives from across the pharmaceutical industry with expert academics, in the common interest of improving the design and translational predictiveness of in vivo models of respiratory disease. Organized by the respiratory representatives of the European Federation of Pharmaceutical Industries and Federations (EFPIA) group of companies involved in the EU-funded project (U-BIOPRED), the aim of the symposium was to identify state-of-the-art improvements in the utility and design of models of respiratory disease, with a view to improving their translational potential and reducing wasteful animal usage. The respiratory research and development community is responding to the challenge of improving translation in several ways: greater collaboration and open sharing of data, careful selection of the species, complexity and chronicity of the models, improved practices in preclinical research, continued refinement in models of respiratory diseases and their sub-types, greater understanding of the biology underlying human respiratory diseases and their sub-types, and finally greater use of human (and especially disease-relevant) cells, tissues and explants. The present review highlights these initiatives, combining lessons from the symposium and papers published in Clinical Science arising from the symposium, with critiques of the models currently used in the settings of asthma, idiopathic pulmonary fibrosis and COPD. The ultimate hope is that this will contribute to a more rational, efficient and sustainable development of a range of new treatments for respiratory diseases that continue to cause substantial morbidity and mortality across the world.

Contrasts between channels and backwaters in a large, floodplain river: Testing our understanding of nutrient cycling, phytoplankton abundance, and suspended solids dynamics

USGS Publications Warehouse

Houser, Jeff N.

2016-01-01

In floodplain rivers, variability in hydraulic connectivity interacts with biogeochemistry to determine the distribution of suspended and dissolved substances. Nutrient, chlorophyll a, and suspended solids data spanning longitudinal (5 study reaches across 1300 river km), lateral (main channel and backwaters), and temporal (1994–2011) gradients in the Upper Mississippi River (UMR) were used to examine the extent to which observed differences between the main channel and backwaters were consistent with expectations based on current understanding of biogeochemical processes in large rivers. For N and P, the results largely conformed to expectations. N concentrations were greater in the main channel than in the backwaters in 82 to 96% of the observations across river reaches. Maximum TP concentrations generally occurred in backwaters during summer, when backwater TP often exceeded that of the main channel. Flux of P from sediments may be a substantial source of water-column P in UMR backwaters in summer. The data for suspended solids and chlorophyll a suggest that some refinements are needed of our understanding of ecosystem processes in large rivers. During low-discharge conditions, concentrations of inorganic suspended solids often were greater in backwaters than in the main channel, suggesting the importance of sediment resuspension. Chlorophyll a concentrations were usually greater in backwaters than in the main channel, but exceptions indicate that phytoplankton abundance in the main channel of the UMR can sometimes be greater than is typically expected for large rivers.

Physician perceptions of the role and value of basic science knowledge in daily clinical practice.

PubMed

Fischer, Jennifer A; Muller-Weeks, Susan

2012-01-01

The role of basic science education in a clinical setting remains unclear. Research to understand how academic clinicians perceive and use this part of their education can aid curricular development. To assess physician's attitudes toward the value of science knowledge in their clinical practice. Academic physicians from three medical schools completed a questionnaire about the utility of basic science education in core clinical tasks and in practice-based learning and improvement. A total of 109 clinical faculty returned the survey. Overall, 89% of the respondents indicated that basic science education is valuable to their clinical practice. When asked about the utility of basic science information in relation to direct patient care, greater than 50% of the doctors felt they use this when diagnosing and communicating with patients. This rose to greater than 60% when asked about choosing treatment options for their patients. Individuals also responded that basic science knowledge is valuable when developing evidence-based best practices. Specifically, 89% felt that they draw upon this information when training students/residents and 84% use this information when reading journal articles. This study shows that basic science education is perceived by responding academic physicians to be important to their clinical work.

The developmental origins of moral concern: An examination of moral boundary decision making throughout childhood

PubMed Central

Wilks, Matti; Redshaw, Jonathan; Nielsen, Mark

2018-01-01

Prominent theorists have made the argument that modern humans express moral concern for a greater number of entities than at any other time in our past. Moreover, adults show stable patterns in the degrees of concern they afford certain entities over others, yet it remains unknown when and how these patterns of moral decision-making manifest in development. Children aged 4 to 10 years (N = 151) placed 24 pictures of human, animal, and environmental entities on a stratified circle representing three levels of moral concern. Although younger and older children expressed similar overall levels of moral concern, older children demonstrated a more graded understanding of concern by including more entities within the outer reaches of their moral circles (i.e., they were less likely to view moral inclusion as a simple in vs. out binary decision). With age children extended greater concern to humans than other forms of life, and more concern to vulnerable groups, such as the sick and disabled. Notably, children’s level of concern for human entities predicted their prosocial behavior. The current research provides novel insights into the development of our moral reasoning and its structure within childhood. PMID:29813134

The developmental origins of moral concern: An examination of moral boundary decision making throughout childhood.

PubMed

Neldner, Karri; Crimston, Daniel; Wilks, Matti; Redshaw, Jonathan; Nielsen, Mark

2018-01-01

Prominent theorists have made the argument that modern humans express moral concern for a greater number of entities than at any other time in our past. Moreover, adults show stable patterns in the degrees of concern they afford certain entities over others, yet it remains unknown when and how these patterns of moral decision-making manifest in development. Children aged 4 to 10 years (N = 151) placed 24 pictures of human, animal, and environmental entities on a stratified circle representing three levels of moral concern. Although younger and older children expressed similar overall levels of moral concern, older children demonstrated a more graded understanding of concern by including more entities within the outer reaches of their moral circles (i.e., they were less likely to view moral inclusion as a simple in vs. out binary decision). With age children extended greater concern to humans than other forms of life, and more concern to vulnerable groups, such as the sick and disabled. Notably, children's level of concern for human entities predicted their prosocial behavior. The current research provides novel insights into the development of our moral reasoning and its structure within childhood.

Health care technology assessment

NASA Astrophysics Data System (ADS)

Goodman, Clifford

1994-12-01

The role of technology in the cost of health care is a primary issue in current debates concerning national health care reform. The broad scope of studies for understanding technological impacts is known as technology assessment. Technology policy makers can improve their decision making by becoming more aware, and taking greater advantage, of key trends in health care technology assessment (HCTA). HCTA is the systematic evaluation of the properties, impacts, and other attributes of health care technologies, including: technical performance; clinical safety and efficacy/effectiveness; cost-effectiveness and other economic attributes; appropriate circumstances/indications for use; and social, legal, ethical, and political impacts. The main purpose of HCTA is to inform technology-related policy making in health care. Among the important trends in HCTA are: (1) proliferation of HCTA groups in the public and private sectors; (2) higher standards for scientific evidence concerning technologies; (3) methodological development in cost analyses, health-related quality of life measurement, and consolidation of available scientific evidence (e.g., meta-analysis); (4) emphasis on improved data on how well technologies work in routine practice and for traditionally under-represented patient groups; (5) development of priority-setting methods; (6) greater reliance on medical informatics to support and disseminate HCTA findings.

Knowledge of memory functions in European and Asian American adults and children: the relation to autobiographical memory.

PubMed

Wang, Qi; Koh, Jessie Bee Kim; Song, Qingfang; Hou, Yubo

2015-01-01

This study investigated explicit knowledge of autobiographical memory functions using a newly developed questionnaire. European and Asian American adults (N = 57) and school-aged children (N = 68) indicated their agreement with 13 statements about why people think about and share memories pertaining to four broad functions-self, social, directive and emotion regulation. Children were interviewed for personal memories concurrently with the memory function knowledge assessment and again 3 months later. It was found that adults agreed to the self, social and directive purposes of memory to a greater extent than did children, whereas European American children agreed to the emotion regulation purposes of memory to a greater extent than did European American adults. Furthermore, European American children endorsed more self and emotion regulation functions than did Asian American children, whereas Asian American adults endorsed more directive functions than did European American adults. Children's endorsement of memory functions, particularly social functions, was associated with more detailed and personally meaningful memories. These findings are informative for the understanding of developmental and cultural influences on memory function knowledge and of the relation of such knowledge to autobiographical memory development.

Dealing with Dependence (Part I): Understanding the Effects of Clustered Data

ERIC Educational Resources Information Center

McCoach, D. Betsy; Adelson, Jill L.

2010-01-01

This article provides a conceptual introduction to the issues surrounding the analysis of clustered (nested) data. We define the intraclass correlation coefficient (ICC) and the design effect, and we explain their effect on the standard error. When the ICC is greater than 0, then the design effect is greater than 1. In such a scenario, the…

Understanding Social Skill Deficits of Mainstreamed Learning Disabled Students and Specialized Strategies Teachers Can Use To Foster Greater Social Acceptance.

ERIC Educational Resources Information Center

Polirstok, Susan Rovet

Utilizing specialized classroom strategies to foster greater social acceptance of mainstreamed learning disabled students may be more efficient than having school personnel constantly involved in resolving student-to-student conflicts and assuaging hurt student feelings. Learning disabled students assigned to mainstream classes often present…

Microhabitat selection of brood-rearing sites by greater sage-grouse in Carbon County, Wyoming

Treesearch

Leslie A. Schreiber; Christopher P. Hansen; Mark A. Rumble; Joshua J. Millspaugh; R. Scott Gamo; Jon W. Kehmeier; Nate Wojcik

2015-01-01

Declines in Greater Sage-Grouse (Centrocercus urophasianus, hereafter sage-grouse) populations could be attributed to low chick survival, which may be influenced by the availability of food and cover at sites used by females rearing broods. Habitat attributes important to broods may vary regionally; thus, it is necessary to understand factors affecting...

The Effects of an Experiential Service-Learning Project on Residential Interior Design Students' Attitudes toward Design and Community

ERIC Educational Resources Information Center

Gomez-Lanier, Lilia

2016-01-01

This mixed research methods study explores whether project-based service-learning projects promote greater learning than standard project-based projects and whether introduced earlier into the curriculum promotes a greater student understanding of the world issues affecting their community. The present study focused on comparing sophomore and…

Global Insurgency to Reestablish the Caliphate; Identifying and Understanding the Enemy

DTIC Science & Technology

2009-05-21

article&id=729: qwe -have-returned- from-the-lesser-jihad-to-the-greater-jihad-jihad-un-nafs-jihad-ul-akbarq&catid=129&Itemid=63 (accessed 31...article&id=729: qwe -have- returned-from-the-lesser-jihad-to-the-greater-jihad-jihad-un-nafs-jihad-ul- akbarq&catid=129&Itemid=63 (accessed February 18, 2009

Large-scale control site selection for population monitoring: an example assessing Sage-grouse trends

USGS Publications Warehouse

Fedy, Bradley C.; O'Donnell, Michael; Bowen, Zachary H.

2015-01-01

Human impacts on wildlife populations are widespread and prolific and understanding wildlife responses to human impacts is a fundamental component of wildlife management. The first step to understanding wildlife responses is the documentation of changes in wildlife population parameters, such as population size. Meaningful assessment of population changes in potentially impacted sites requires the establishment of monitoring at similar, nonimpacted, control sites. However, it is often difficult to identify appropriate control sites in wildlife populations. We demonstrated use of Geographic Information System (GIS) data across large spatial scales to select biologically relevant control sites for population monitoring. Greater sage-grouse (Centrocercus urophasianus; hearafter, sage-grouse) are negatively affected by energy development, and monitoring of sage-grouse population within energy development areas is necessary to detect population-level responses. Weused population data (1995–2012) from an energy development area in Wyoming, USA, the Atlantic Rim Project Area (ARPA), and GIS data to identify control sites that were not impacted by energy development for population monitoring. Control sites were surrounded by similar habitat and were within similar climate areas to the ARPA. We developed nonlinear trend models for both the ARPA and control sites and compared long-term trends from the 2 areas. We found little difference between the ARPA and control sites trends over time. This research demonstrated an approach for control site selection across large landscapes and can be used as a template for similar impact-monitoring studies. It is important to note that identification of changes in population parameters between control and treatment sites is only the first step in understanding the mechanisms that underlie those changes. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

Alcohol policy in South Africa: a review of policy development processes between 1994 and 2009.

PubMed

Parry, Charles D H

2010-08-01

Implementation of effective policies to reduce harmful alcohol consumption requires both a good understanding of the policy development process and which strategies are likely to work. To contribute to this understanding by reviewing four specific policy development initiatives that have taken place in South Africa between 1994 and 2009: restrictions on alcohol advertising and counter-advertising, regulation of retail sales of alcohol, alcohol taxation and controls on alcohol packaging. Material was drawn from a record of meetings and conferences held between 1994 and 2009 and a database of reports, newspaper clippings and policy documentation. When the policy process resulted in a concrete outcome there was always a clear recognition of the problem and policy alternatives, but success was more likely if there was an alignment of 'political' forces and/or when there was a determined bureaucracy. The impact of the other factors such as the media, community mobilization, non-governmental organizations (NGOs), the liquor industry and research are also discussed. Future avenues for policy research are identified, including the need for more systematic studies that give greater consideration to economic factors. Alcohol policy development in South Africa takes place in a piecemeal fashion and is the product of various competing influences. Having a comprehensive national alcohol strategy cutting across different sectors may be a better way for other developing countries to proceed.

Applications of systems approaches in the study of rheumatic diseases.

PubMed

Kim, Ki-Jo; Lee, Saseong; Kim, Wan-Uk

2015-03-01

The complex interaction of molecules within a biological system constitutes a functional module. These modules are then acted upon by both internal and external factors, such as genetic and environmental stresses, which under certain conditions can manifest as complex disease phenotypes. Recent advances in high-throughput biological analyses, in combination with improved computational methods for data enrichment, functional annotation, and network visualization, have enabled a much deeper understanding of the mechanisms underlying important biological processes by identifying functional modules that are temporally and spatially perturbed in the context of disease development. Systems biology approaches such as these have produced compelling observations that would be impossible to replicate using classical methodologies, with greater insights expected as both the technology and methods improve in the coming years. Here, we examine the use of systems biology and network analysis in the study of a wide range of rheumatic diseases to better understand the underlying molecular and clinical features.

Innovations in Mission Architectures for Human and Robotic Exploration Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Cooke, Douglas R.; Joosten, B. Kent; Lo, Martin W.; Ford, Ken; Hansen, Jack

2002-01-01

Through the application of advanced technologies, mission concepts, and new ideas in combining capabilities, architectures for missions beyond Earth orbit have been dramatically simplified. These concepts enable a stepping stone approach to discovery driven, technology enabled exploration. Numbers and masses of vehicles required are greatly reduced, yet enable the pursuit of a broader range of objectives. The scope of missions addressed range from the assembly and maintenance of arrays of telescopes for emplacement at the Earth-Sun L2, to Human missions to asteroids, the moon and Mars. Vehicle designs are developed for proof of concept, to validate mission approaches and understand the value of new technologies. The stepping stone approach employs an incremental buildup of capabilities; allowing for decision points on exploration objectives. It enables testing of technologies to achieve greater reliability and understanding of costs for the next steps in exploration.

Do infants influence their quality of care? Infants' communicative gestures predict caregivers' responsiveness.

PubMed

Vallotton, Claire D

2009-12-01

Infants' effects on adults are a little studied but important aspect of development. What do infants do that increases caregiver responsiveness in childcare environments? Infants' communicative behaviors (i.e. smiling, crying) affect mothers' responsiveness; and preschool children's language abilities affect teachers' responses in the classroom setting. However, the effects of infants' intentional communications on either parents' or non-parental caregivers' responsiveness have not been examined. Using longitudinal video data from an infant classroom where infant signing was used along with conventional gestures (i.e. pointing), this study examines whether infants' use of gestures and signs elicited greater responsiveness from caregivers during daily interactions. Controlling child age and individual child effects, infants' gestures and signs used specifically to respond to caregivers elicited more responsiveness from caregivers during routine interactions. Understanding the effects of infants' behaviors on caregivers is critical for helping caregivers understand and improve their own behavior towards children in their care.

Politics or Technocracy – What Next for Global Health?

PubMed Central

Kickbusch, Ilona

2016-01-01

Politics play a central part in determining health and development outcomes as Gorik Ooms highlights in his recent commentary. As health becomes more global and more politicized the need grows to better understand the inherently political processes at all levels of governance, such as ideological positions, ideas, value judgments, and power. I agree that global health research should strengthen its contribution to generating such knowledge by drawing more on political science, such research is gaining ground. Even more important is – as Ooms indicates – that global health scholars better understand their own role in the political process. It is time to acknowledge that expert-based technocratic approaches are no less political. We will need to reflect and analyse the role of experts in global health governance to a greater extent and in that context explore the links between politics, expertise and democracy. PMID:26927593

Understanding the experiences and needs of lesbian, gay, bisexual and trans Australians living with dementia, and their partners.

PubMed

Barrett, Catherine; Crameri, Pauline; Lambourne, Sally; Latham, J R; Whyte, Carolyn

2015-10-01

To outline the experiences and needs of lesbian, gay, bisexual and trans (LGBT) Australians living with dementia - and their partners. In-depth interviews were conducted with LGBT people, their partners and service providers. LGBT people living with dementia experience unique challenges including the failure of some families of origin and service providers to understand and value their sexual orientation or gender identity. The fear of discrimination by service providers results in greater reliance on intimate partners for care and compounds social isolation. The unique experiences of LGBT people with dementia are not well understood. There is a need to recognise historical experiences, including familial relationships, and provide advocacy to ensure sexual and gender rights are not violated. There is also a need to ensure that the experiences and perspectives of LGBT people living with dementia inform the development of services. © 2015 AJA Inc.

The social comfort of wearable technology and gestural interaction.

PubMed

Dunne, Lucy E; Profita, Halley; Zeagler, Clint; Clawson, James; Gilliland, Scott; Do, Ellen Yi-Luen; Budd, Jim

2014-01-01

The "wearability" of wearable technology addresses the factors that affect the degree of comfort the wearer experiences while wearing a device, including physical, psychological, and social aspects. While the physical and psychological aspects of wearing technology have been investigated since early in the development of the field of wearable computing, the social aspects of wearability have been less fully-explored. As wearable technology becomes increasingly common on the commercial market, social wearability is becoming an ever-more-important variable contributing to the success or failure of new products. Here we present an analysis of social aspects of wearability within the context of the greater understanding of wearability in wearable technology, and focus on selected theoretical frameworks for understanding how wearable products are perceived and evaluated in a social context. Qualitative results from a study of social acceptability of on-body interactions are presented as a case study of social wearability.

A Historical Review of R. J. Reynolds’ Strategies for Marketing Tobacco to Hispanics in the United States

PubMed Central

Parascandola, Mark

2013-01-01

Hispanics are the fastest growing racial/ethnic group in the United States, and smoking is the leading preventable cause of morbidity and mortality among this population. We analyzed tobacco industry documents on R. J. Reynolds’ marketing strategies toward the Hispanic population using tobacco industry document archives from the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February–July 2011 and April–August 2012. Our analysis revealed that by 1980 the company had developed a sophisticated surveillance system to track the market behavior of Hispanic smokers and understand their psychographics, cultural values, and attitudes. This information was translated into targeted marketing campaigns for the Winston and Camel brands. Marketing targeted toward Hispanics appealed to values and sponsored activities that could be perceived as legitimating. Greater understanding of tobacco industry marketing strategies has substantial relevance for addressing tobacco-related health disparities. PMID:23488493

Guilt and shame: experiences of parents of self-harming adolescents.

PubMed

McDonald, Glenda; O'Brien, Louise; Jackson, Debra

2007-12-01

This paper reports the findings of a qualitative study that used a hermeneutic phenomenological methodology to develop insights into the experience of parents of young people who engage in self-harming behaviour. Six mothers (and one father who accompanied his wife) participated in the study. Findings reveal that mothers experienced guilt and shame, and that these feelings shaped their reactions and responses. These mothers described experiencing emotional dilemmas, such as the degree to which they could be responsible, uncertainty about how to understand self harm, and the best course of action to take with their child. They also encountered difficulties in combating the negative emotional effects for themselves and other family members. Findings provide insights that can help nurses and family health workers to understand and assist parents with greater effectiveness; by maintaining a non-judgemental stance, acknowledging the difficulties of their experiences, encouraging confidence in their parenting abilities, and promoting effective stress management strategies.

Latinos, acculturation, and acculturative stress: a dimensional concept analysis.

PubMed

Caplan, Susan

2007-05-01

Acculturation can be conceived of as a process of adaptation to stressful changes. In the field of public health, research indicates that recently arrived Latino immigrants, presumably most affected by acculturative stress, have better health outcomes than those who have spent greater time in the United States. This "immigrant paradox" is not well understood but supports the distinction between the process of acculturation and acculturative stress. To understand the nature of acculturative stress for Latinos in the context of political, historical, and societal forces. Acculturative stress significantly affects the physical and mental health of many Latino immigrants. Types of stressors vary by ethnicity. Separation from family and lack of a community was the most often-cited stressor for new immigrants. Most Latino immigrants were adversely affected by discrimination. By developing an understanding of acculturative stress, nurses can better attend to the needs of our increasingly diverse population.

Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators.

PubMed

Edwards, Michael R; Saglani, Sejal; Schwarze, Jurgen; Skevaki, Chrysanthi; Smith, Jaclyn A; Ainsworth, Ben; Almond, Mark; Andreakos, Evangelos; Belvisi, Maria G; Chung, Kian Fan; Cookson, William; Cullinan, Paul; Hawrylowicz, Catherine; Lommatzsch, Marek; Jackson, David; Lutter, Rene; Marsland, Benjamin; Moffatt, Miriam; Thomas, Mike; Virchow, J Christian; Xanthou, Georgina; Edwards, Jessica; Walker, Samantha; Johnston, Sebastian L

2017-05-01

Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes. Copyright ©ERS 2017.

A historical review of R.J. Reynolds' strategies for marketing tobacco to Hispanics in the United States.

PubMed

Iglesias-Rios, Lisbeth; Parascandola, Mark

2013-05-01

Hispanics are the fastest growing racial/ethnic group in the United States, and smoking is the leading preventable cause of morbidity and mortality among this population. We analyzed tobacco industry documents on R. J. Reynolds' marketing strategies toward the Hispanic population using tobacco industry document archives from the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February-July 2011 and April-August 2012. Our analysis revealed that by 1980 the company had developed a sophisticated surveillance system to track the market behavior of Hispanic smokers and understand their psychographics, cultural values, and attitudes. This information was translated into targeted marketing campaigns for the Winston and Camel brands. Marketing targeted toward Hispanics appealed to values and sponsored activities that could be perceived as legitimating. Greater understanding of tobacco industry marketing strategies has substantial relevance for addressing tobacco-related health disparities.

Social Relationships and Inflammatory Markers in the MIDUS Cohort.

PubMed

Elliot, Ari J; Heffner, Kathi L; Mooney, Christopher J; Moynihan, Jan A; Chapman, Benjamin P

2017-03-01

To better understand age and gender differences in associations of social relationships with chronic inflammation. Using a sample of middle-aged and older adults ( N = 963) from the Midlife Development in the United States (MIDUS) biomarker project, we examined interactions of age and gender with structural and functional social network measures in predicting interleukin-6 (IL-6) and C-reactive protein (CRP). Significant interactions involving age and gender showed that social support was associated with lower IL-6 in older women, whereas perceived positive relationships and social integration were related to lower IL-6 in both men and women of advanced age. Functional measures were associated with higher CRP in both men and women after adjustment for health conditions and behaviors, with some further variation by age. Greater social support may be related to lower IL-6 in older women. Further research is needed to understand observed associations of social support with higher CRP.

An effective method for terrestrial arthropod euthanasia.

PubMed

Bennie, Neil A C; Loaring, Christopher D; Bennie, Mikaella M G; Trim, Steven A

2012-12-15

As scientific understanding of invertebrate life increases, so does the concern for how to end that life in an effective way that minimises (potential) suffering and is also safe for those carrying out the procedure. There is increasing debate on the most appropriate euthanasia methods for invertebrates as their use in experimental research and zoological institutions grows. Their popularity as pet species has also led to an increase in the need for greater veterinary understanding. Through the use of a local injection of potassium chloride (KCl) initially developed for use in American lobsters, this paper describes a safe and effective method for euthanasia in terrestrial invertebrates. Initial work focused on empirically determining the dose for cockroaches, which was then extrapolated to other arthropod species. For this method of euthanasia, we propose the term 'targeted hyperkalosis' to describe death through terminal depolarisation of the thoracic ganglia as a result of high potassium concentration.

Perceptions of Adolescent Pregnancy Among Teenage Girls in Rakai, Uganda

PubMed Central

Maly, Christina; McClendon, Katherine A.; Baumgartner, Joy Noel; Nakyanjo, Neema; Ddaaki, William George; Serwadda, David; Nalugoda, Fred Kakaire; Wawer, Maria J.; Bonnevie, Erika; Wagman, Jennifer A.

2017-01-01

The leading causes of death and disability among Ugandan female adolescents aged 15 to 19 years are pregnancy complications, unsafe abortions, and childbirth. Despite these statistics, our understanding of how girls perceive adolescent pregnancy is limited. This qualitative study explored the social and contextual factors shaping the perceptions of adolescent pregnancy and childbirth among a sample of 12 currently pregnant and 14 never pregnant girls living in the rural Rakai District of Uganda. Interviews were conducted to elicit perceived risk factors for pregnancy, associated community attitudes, and personal opinions on adolescent pregnancy. Findings indicate that notions of adolescent pregnancy are primarily influenced by perceptions of control over getting pregnant and readiness for childbearing. Premarital pregnancy was perceived as negative whereas postmarital pregnancy was regarded as positive. Greater understanding of the individual and contextual factors influencing perceptions can aid in development of salient, culturally appropriate policies and programs to mitigate unintended adolescent pregnancies. PMID:28835911