[Nanomaterials--proposals of occupational exposure limits in the world and hygiene standards in Poland].

PubMed

Swidwińska-Gajewska, Anna Maria; Czerczak, Sławomir

2013-01-01

Currently, there are no legally binding workplace exposure limits for substances in the form of nanoobjects. There are different ap proaches to risk assessment and determination of occupational exposure limits. The purpose of this article is to compare exposure levels in the work environment proposed by international organizations and world experts, as well as the assumptions and methods used for their estimation. This paper presents the proposals of the National Institute for Public Health and the Environment in the Netherlands (RIVM), the New Energy and Industrial Technology Development Organization in Japan (NEDO) and the National Institute for Occupational Safety and Health in the USA (NIOSH). The authors also discuss the reports on the levels for carbon nanotubes (Baytubes and Nanocyl) proposed by Pauluhn and Luizi, the derived no-effect levels (DNEL) complying with the REACH Regulation, proposed by experts under the 7th Framework Programme of the European Commission, coordinated by Professor Vicki Stone (ENRHES), and alternative estimation levels for poorly soluble particles by Pauluhn. The issue was also raised whether the method of determining maximum admissible concentrations in the work environment, currently used in Poland, is adequate for nanoobjects. Moreover, the introduction of nanoreference values, as proposed by RIVM, the definition of a new fraction for particles of 1-100 nm, taking into account the surface area and activity of the particles, and an adequate estimation of uncertainty factors seem to be worth considering. Other important, if not key issues are the appropriate measurement (numerical concentration, surface concentration, particle size distribution), as well as the methodology and equipment accessibility to all employers responsible for a reliable risk assessment of exposure to nanoparticles in the work environment.

Development of the EM tomography system by the vertical electromagnetic profiling (VEMP) method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miura, Y.; Osato, K.; Takasugi, S.

1995-12-31

As a part of the {open_quotes}Deep-Seated Geothermal Resources Survey{close_quotes} project being undertaken by the NEDO, the Vertical ElectroMagnetic Profiling (VEMP) method is being developed to accurately obtain deep resistivity structure. The VEMP method acquires multi-frequency three-component magnetic field data in an open hole well using controlled sources (loop sources or grounded-wire sources) emitted at the surface. Numerical simulation using EM3D demonstrated that phase data of the VEMP method is very sensitive to resistivity structure and the phase data will also indicate presence of deep anomalies. Forward modelling was also used to determine required transmitter moments for various grounded-wire and loopmore » sources for a field test using the WD-1 well in the Kakkonda geothermal area. Field logging of the well was carried out in May 1994 and the processed field data matches well the simulated data.« less

Preface

NASA Astrophysics Data System (ADS)

2003-09-01

MEM03: The Second International Workshop on Mechano-Electromagnetic Properties of Composite Superconductors (Kyoto, Japan, 3–5 March 2003) Superconductivity is on course to be widely applied in various advanced technologies including: (1) magnetically levitated vehicles (MAGLEV), international thermonuclear experimental reactors (ITER), electric generators, high energy accelerator and magnetic resonance imaging (MRI) using metallic composite superconductors; (2) cable, fault-current-limiters (FCL), transformers, flywheels and motors by using oxide composite superconductors; (3) high field NMR and other sophisticated devices by combining both metallic and oxide superconductors. In order to create a real market for these advanced technologies using superconductivity, it is absolutely essential to develop superconducting wires/tapes with better performance. The development of accompanying assessment technologies is therefore indispensable for their R&D. Some important properties are related to the mechanical properties of the conductors. It is well known that degraded superconducting and mechanical properties (during fabrication as well as under operation) can cause serious problems, because the critical current depends sensitively on bending and tensile stresses, electromagnetic force, and mechanical and thermal cycling. Therefore he assessment of mechanical properties and the effect of strain on transport properties is crucial for improving and developing high performance superconducting devices. It is now very timely to have a meeting in order to discuss common scientific problems systematically and comprehensively. The Second International Workshop on Mechano-Electromagnetic Properties of Composite Superconductors, MEM03, was held in Kyoto, Japan, 3–5 March 2003, mainly to discuss the fundamentals of the following topics. • Electromagnetic properties: change of critical current, RRR and ac loss due to external forces like bending, compressive and tensile stresses, electromagnetic force, and mechanical and thermal cycling. • Mechanical properties: tensile and compressive properties, fatigue characteristics and fracture behaviour. • Thermal properties: thermal conductivity, thermal dilatation and thermal strain. • Modelling: prediction of critical current and mechanical properties of composite superconductors through statistical analysis, finite element analysis, etc. • Test methods: international cooperative research work to establish test methods for assessing mechano-electromagnetic properties based on the activity of VAMAS/TWA-16. This discussion took place with respect to three types of composites: • MFC (multifilamentary composite): BSCCO, MgB2, Nb-Ti, Nb3Sn and Nb3Al. • CCC (coated conductor composite): YBCO and ReBCO. • BCC (bulk crystal composite): YBCO and ReBCO. More than 55 researchers attended the MEM03 workshop, coming from eight different countries. A total of 42 papers were presented. In this special issue of Superconductor Science and Technology selected papers have been included that are concerned with the comprehensive scientific research subjects mentioned above. The aim of this issue is to provide a snapshot of some of the current state-of-the-art research and to promote further research into the mechano-electromagnetic properties of composite superconductors. The workshop was organized under the activities of NEDO technology quest and VAMAS/TWA-16. We wish to thank the following for their contribution to the success of the workshop: NEDO Super-ACE project, AFOSR, AOARD and IEC/TC90-JNC. Guest Editors: Kozo Osamura Hitoshi Wada Arman Nyilas Damian Hampshire

Forecast Method of Solar Irradiance with Just-In-Time Modeling

NASA Astrophysics Data System (ADS)

Suzuki, Takanobu; Goto, Yusuke; Terazono, Takahiro; Wakao, Shinji; Oozeki, Takashi

PV power output mainly depends on the solar irradiance which is affected by various meteorological factors. So, it is required to predict solar irradiance in the future for the efficient operation of PV systems. In this paper, we develop a novel approach for solar irradiance forecast, in which we introduce to combine the black-box model (JIT Modeling) with the physical model (GPV data). We investigate the predictive accuracy of solar irradiance over wide controlled-area of each electric power company by utilizing the measured data on the 44 observation points throughout Japan offered by JMA and the 64 points around Kanto by NEDO. Finally, we propose the application forecast method of solar irradiance to the point which is difficulty in compiling the database. And we consider the influence of different GPV default time on solar irradiance prediction.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peter H. Israelsson; E. Eric Adams

On December 4, 1997, the US Department of Energy (USDOE), the New Energy and Industrial Technology Development Organization of Japan (NEDO), and the Norwegian Research Council (NRC) entered into a Project Agreement for International Collaboration on CO{sub 2} Ocean Sequestration. Government organizations from Japan, Canada, and Australia, and a Swiss/Swedish engineering firm later joined the agreement, which outlined a research strategy for ocean carbon sequestration via direct injection. The members agreed to an initial field experiment, with the hope that if the initial experiment was successful, there would be subsequent field evaluations of increasingly larger scale to evaluate environmental impactsmore » of sequestration and the potential for commercialization. The evolution of the collaborative effort, the supporting research, and results for the International Collaboration on CO{sub 2} Ocean Sequestration were documented in almost 100 papers and reports, including 18 peer-reviewed journal articles, 46 papers, 28 reports, and 4 graduate theses. These efforts were summarized in our project report issued January 2005 and covering the period August 23, 1998-October 23, 2004. An accompanying CD contained electronic copies of all the papers and reports. This report focuses on results of a two-year sub-task to update an environmental assessment of acute marine impacts resulting from direct ocean sequestration. The approach is based on the work of Auerbach et al. [6] and Caulfield et al. [20] to assess mortality to zooplankton, but uses updated information concerning bioassays, an updated modeling approach and three modified injection scenarios: a point release of negatively buoyant solid CO{sub 2} hydrate particles from a moving ship; a long, bottom-mounted diffuser discharging buoyant liquid CO{sub 2} droplets; and a stationary point release of hydrate particles forming a sinking plume. Results suggest that in particular the first two discharge modes could be successfully designed to largely avoid zooplankton mortality. Sub-lethal and ecosystem effects are discussed qualitatively, but not analyzed quantitatively.« less

Overview of demonstrator program of Japanese Smart Materials and Structure System project

NASA Astrophysics Data System (ADS)

Tajima, Naoyuki; Sakurai, Tateo; Sasajima, Mikio; Takeda, Nobuo; Kishi, Teruo

2003-08-01

The Japanese Smart Material and Structure System Project started in 1998 as five years' program that funded by METI (Ministry of Economy, Trade and Industry) and supported by NEDO (New Energy and Industrial Technology Development Organization). Total budget of five years was finally about 3.8 billion Japanese yen. This project has been conducted as the Academic Institutions Centered Program, namely, one of collaborated research and development among seven universities (include one foreign university), seventeen Industries (include two foreign companies), and three national laboratories. At first, this project consisted of four research groups that were structural health monitoring, smart manufacturing, active/adaptive structures, and actuator material/devices. Two years later, we decided that two demonstrator programs should be added in order to integrate the developed sensor and actuator element into the smart structure system and verify the research and development results of above four research groups. The application target of these demonstrators was focused to the airplane, and two demonstrators that these shapes simulate to the fuselage of small commercial airplane (for example, Boeing B737) had been established. Both demonstrators are cylindrical structures with 1.5 m in diameter and 3 m in length that the first demonstrator has CFRP skin-stringer and the second one has CFRP skin. The first demonstrator integrates the following six innovative techniques: (1) impact monitoring using embedded small diameter optical fiber sensors newly developed in this program, (2) impact monitoring using the integrated acoustic emission (AE) systems, (3) whole-field strain mapping using the BOTDR/FBG integrated system, (4) damage suppression using embedded shape memory alloy (SMA) films, (5) maximum and cyclic strain sensing using smart composite patches, and (6) smart manufacturing using the integrated sensing system. The second one is for demonstrating the suppression of vibration and acoustic noise generated in the composite cylindrical structure. In this program, High-performance PZT actuators/sensors developed in this program are also installed. The whole tests and evaluations have now been finished. This paper presents the outline of demonstrator programs, followed by six presentations that show the detail verification results of industrial demonstration themes.

Nano-defect management in directed self-assembly of block copolymers (Conference Presentation)

NASA Astrophysics Data System (ADS)

Azuma, Tsukasa; Seino, Yuriko; Sato, Hironobu; Kasahara, Yusuke; Kodera, Katsuyoshi; Jiravanichsakul, Phubes; Hayakawa, Teruaki; Yoshimoto, Kenji; Takenaka, Mikihito

2017-03-01

Directed self-assembly (DSA) of block copolymers (BCPs) has been expected to become one of the most promising next generation lithography candidates for sub-15 nm line patterning and sub-20 nm contact hole patterning. In order to provide the DSA lithography to practical use in advanced semiconductor device manufacturing, defect mitigation in the DSA materials and processes is the primary challenge. We need to clarify the defect generation mechanism using in-situ measurement of self-assembling processes of BCPs in cooperation with modeling approaches to attain the DSA defect mitigation. In this work, we thus employed in-situ atomic force microscope (AFM) and grazing-incidence small angle X-ray scattering (GI-SAXS) and investigated development of surface morphology as well as internal structure during annealing processes. Figure 1 shows series of the AFM images of PMAPOSS-b-PTFEMA films during annealing processes. The images clearly show that vitrified sponge-like structure without long-range order in as-spun film transforms into lamellar structure and that the long range order of the lamellar structure increases with annealing temperature. It is well-known that ordering processes of BCPs from disordered state in bulk progress via nucleation and growth. In contrary to the case of bulk, the observed processes seem to be spinodal decomposition. This is because the structure in as-spun film is not the concentration fluctuation of disordered state but the vitrified sponge-like structure. The annealing processes induce order-order transition from non-equilibrium ordered-state to the lamellar structure. The surface tension assists the transition and directs the orientation. Figure 2 shows scattering patterns of (a) vicinity of film top and (b) whole sample of the GI-SAXS. We can find vertically oriented lamellar structure in the vicinity of film top while horizontally oriented lamellar structures in the vicinity of film bottom, indicating that the GI-SAXS measurement can clarify the variation of the morphologies in depth direction and that the surface tension affects the orientation of the lamellar structure. Finally a combination of the time development data in the in-situ AFM and the GI-SAXS is used to develop a kinetic modeling for prediction of dynamical change in three-dimensional nano-structures. A part of this work was funded by the New Energy and Industrial Technology Development Organization (NEDO) in Japan under the EIDEC project.

Feasibility survey on international cooperation for high efficiency energy conversion technology in fiscal 1993

NASA Astrophysics Data System (ADS)

1994-03-01

Following cooperative researches on fuel cell jointly conducted by NEDO and EGAT (Electricity Generating Authority of Thailand), the survey on international cooperation relating to high efficiency energy conversion technology was carried out for the ASEAN countries. The paper summed up the results of the survey. The study of the international cooperation is made for the following three items: a program for periodical exchange of information with EGAT, a project for cooperative research on phosphoric acid fuel cell in Indonesia, and a project for cooperative research with EGAT on electric power storage by advanced battery. In Malaysia, which is small in scale of state, part of the Ministry of Energy, Telecommunication and Posts is only in charge of the energy issue. Therefore, the situation is that they cannot answer well to many items of research/development cooperation brought in from Japan. The item of medium- and long-term developmental research in the Philippines is about the problems which are seen subsequently in the Manila metropolitan area where the problem of outage is being settled. Accordingly, it is essential to promote the cooperative research, well confirming policies and systems of the Ministry of Energy and the national electricity corporation.

Overview of superconductivity in Japan Strategy road map and R&D status

NASA Astrophysics Data System (ADS)

Tsukamoto, O.

2008-09-01

Superconducting technology benefits society in broad fields; environment/energy, life science, manufacturing industry and information and communication. Superconducting equipments and devices used in various fields are divided into two categories, electric and electronic applications. Technologies in those applications are progressing remarkably owing to firm and consistent supports by various national projects. The final target of the NEDO R&D project of fundamental technology for superconductivity applications to develop 500 m long coated conductors (CCs) of the critical current 300 A/cm (at 77 K, 0 T) will be fulfilled by the end of JFY 2007 and manufacturing process to produce extremely low-cost CCs is to be developed to make the applications realistic. Preliminary works to develop power apparatuses using CCs have started in the frame of the R&D project for the fundamental technology and have produced significant results. Performance of BSCCO/Ag-sheathed wires has been improved greatly and various applications using those wires are being developed. R&D projects for SMES, power cable, flywheel energy storage and rotating machines are going to introduce those equipments to the real world. Technologies of SQUID and SFQ, basic devices of the electronic applications, are progressing dramatically also owing to various national projects. In this back ground the technology strategy map in the field of superconducting technology was formulated to prioritize investments in R&D by clearly defining the objectives and inspire autonomous R&D actives in various fields of industries. R&D activities in the superconducting technologies are to be scheduled following this strategy map.

Supply and Demand Control of Distributed Generators in a Microgrid for New Energy

NASA Astrophysics Data System (ADS)

Shimakage, Toyonari; Sumita, Jiro; Uchiyama, Noriyuki; Kato, Takeyoshi; Suzuoki, Yasuo

We report the operational results of distributed generators (DGs) in a microgrid and present the effects after incorporating photovoltaic power generation (PV) systems into the microgrid for electric power system. The microgrid was constructed at the EXPO 2005 Aichi site as part of a demonstration promoted by NEDO. A solution is needed to problems where instability in the DGs that utilize natural energy such as solar light and wind force negatively influence existing electric power systems. So, we developed energy control system and controlled DGs output to reduce the fluctuation at the grid connected point caused by PV system's instability output. Our microgrid consists of DGs such as PV systems, fuel cells, and NaS batteries, and these DGs are controlled by an energy control system. We verified practical effectiveness of the installing the microgrid as follows. (1) 99.5% of the power imbalance in the supply and demand over 30 minutes was within a range of ±3% under normal operating conditions, (2) the microgrid contributes to the load leveling, (3) energy control system smoothes the power flow fluctuation of PV system output at the grid connected point, (4) in the future, installing a microgrid will help reduce the additional LFC (Load Frequency Control) capacity.

Momentum Dependence of Charge Excitations in YBa2Cu3O7-δ and Nd2-xCexCuO4

NASA Astrophysics Data System (ADS)

Ishii, Kenji

2006-03-01

Resonant inelastic x-ray scattering (RIXS) studies at Cu K-edge on high-Tc superconducting cuprates, YBa2Cu3O7-δ and Nd2-xCexCuO4 are presented. The superconductivity occurs in the vicinity of the Mott insulating state and it is important to clarify the nature of the Mott gap and its doping dependence. Because RIXS has an advantage that we can measure charge excitation in a wide energy-momentum space, it gives a unique opportunity to study the electronic structure of materials. We apply this technique to high-Tc superconducting cuprates. In particular the electronic structure of strongly correlated metals is in the focus of our RIXS study. The experiments were performed at BL11XU of SPring-8, Japan, where a specially designed spectrometer for inelastic x-ray scattering is installed. In optimally doped YBa2Cu3O7-δ, anisotropic spectra are observed in the ab plane of a twin-free crystal. The Mott gap excitation from the one-dimensional CuO chain is enhanced at 2 eV near the zone boundary of the chain direction, while the excitation from the CuO2 plane is broad at 1.5-4 eV and almost independent of momentum. Theoretical calculation based on the one-dimensional and two-dimensional Hubbard model reproduces the observed features in the RIXS spectra when smaller values of the on-site Coulomb energy of the chain than that of the plane are assumed. This means that the charge transfer gap of the chain is smaller than that of the plane. On the other hand, both interband excitation across the Mott gap and intraband excitation in the upper Hubbard band are observed in the electron-doped Nd2-xCexCuO4. The intensity of the interband excitation is concentrated at ˜ 2 eV near the zone boundary while a dispersion relation with a momentum-dependent width emerges in the intraband excitation. The author would like to acknowledge to his collaborators, K. Tsutsui, Y. Endoh, T. Tohyama, K. Kuzushita, T. Inami, K. Ohwada, M. Hoesch, M. Tsubota, Y. Murakami, J. Mizuki, S. Maekawa, T. Masui, S. Tajima, and K. Yamada. The crystal growth of YBa2Cu3O7-δ was supported by the New Energy and Industrial Technology Development Organization (NEDO) as the Collaborative Research and Development of Fundamental Technologies for Superconductivity Applications.

PREFACE: MEM07: The 5th Annual Workshop on Mechanical and Electromagnetic Properties of Composite Superconductors (Princeton, NJ, USA, 21 24 August 2007)

NASA Astrophysics Data System (ADS)

Larbalestier, D. C.; Osamura, K.; Hampshire, D. P.

2008-05-01

MEM07 was the 5th international workshop concentrating on the mechanical and electrical properties of composite superconductors, which are the technological conductor forms from which practical superconducting devices are made. Such superconducting conductors respond to important challenges we currently face, especially those concerned with the proper management of the world's energy resources. Superconductivity provides a means to address the challenges in the generation, transmission and distribution, and use of energy. For energy generation, the ITER Fusion Tokomak (now underway in France) provides exciting new challenges for the whole superconductivity community, due to the enormous size and strong fields of the plasma confinement superconducting magnets that will form the largest and most powerful superconducting machine yet built. Significant attention was paid at MEM07 to the modeling, characterization, testing and validation of the high-amperage Nb3Sn cable-in-conduit conductors needed for ITER. As for electric energy industry uses, there was much discussion of both first generation (Bi,Pb)2Sr2Ca2Cu3Ox conductors and the rapidly emerging second generation coated conductors made from YBa2Cu37-x. High-performing, affordable conductors of these materials are vital for large capacity transmission cables, energy storage systems, fault current limiters, generators and motors—many prototypes of which are being pursued in technologically advanced countries. There is a broad consensus that the prototype stage for high-current-high-field superconducting applications is nearing its end and that large scale applications are technologically feasible. However full industrialization of large-scale superconducting technologies in electric utility applications will benefit from continuous improvement in critical current, lower ac loss, higher strength and other vital conductor properties. The establishment of optimal procedures for the system design accompanying scale-up is a second vital task. As system design is dependent on material development, there is a critical need to study the key issues in developing high performance superconducting materials. The emphases of MEM07 were The mechanical properties of superconductors including the influence of stress and strain on the critical current of practical conductors including YBCO and ReBCO coated conductors, BSCCO tapes, MgB2 wires and Nb3Sn filamentary conductors. The intrinsic strain effects on critical current density in Nb3Sn, YBCO, BSCCO and MgB2. Recent advances in critical current, the mechanical properties and the reduction in ac losses of HTS tapes and wires. The compositional and microstructural dependence of E-J characteristics and explanations based on flux pinning, grain boundary weak-links and other mechanisms. Standardized test-methods: international cooperative research work to establish test methods for assessing the mechano-electromagnetic properties of superconductors based on the activities of IEC/TC90 and VAMAS/TWA-16. More than 60 researchers from more than 12 countries attended the MEM07 workshop, and about 40 presentations were made. A small selection of papers (15) from the workshop are included in this special issue of Superconductor Science and Technology. Taken together with papers published at earlier MEM meetings, this issue provides an updated view of some of the current state-of-the-art research in the mechano-electromagnetic properties of composite superconductors. The workshop was organized under the activities of the NEDO Grant Project (Applied Superconductivity, 2004EA004) and VAMAS/TWA-16. The meeting was organized by a committee composed of David Larbalestier (Conference Chair) aided by MEM05 and MEM06 Conference Chairs Kozo Osamura (Research Institute for Applied Sciences, Kyoto, Japan), Damian Hampshire (Durham University, UK) and Arman Nyilas (CEME). The Program Committee was composed of Ettore Salpietro (European Fusion Development Agreement), Neil Mitchell (ITER), Kozo Osamura, Damian Hampshire and Arman Nyilas. We express our great thanks to all those whose efforts were key in organizing the meeting, with very special thanks to our Meeting Planner Kate Liu who organized matters large and small with discretion and great efficiency.

The update of resist outgas testing for metal containing resists at EIDEC

NASA Astrophysics Data System (ADS)

Shiobara, Eishi; Mikami, Shinji

2017-10-01

The metal containing resist is one of the candidates for high sensitivity resists. EIDEC has prepared the infrastructure for outgas testing in hydrogen environment for metal containing resists at High Power EUV irradiation tool (HPEUV). We have experimentally obtained the preliminary results of the non-cleanable metal contamination on witness sample using model material by HPEUV [1]. The metal contamination was observed at only the condition of hydrogen environment. It suggested the generation of volatile metal hydrides by hydrogen radicals. Additionally, the metal contamination on a witness sample covered with Ru was not removed by hydrogen radical cleaning. The strong interaction between the metal hydride and Ru was confirmed by the absorption simulation. Recently, ASML announced a resist outgassing barrier technology using Dynamic Gas Lock (DGL) membrane located between projection optics and wafer stage [2], [3]. DGL membrane blocks the diffusion of all kinds of resist outgassing to the projection optics and prevents the reflectivity loss of EUV mirrors. The investigation of DGL membrane for high volume manufacturing is just going on. It extends the limitation of material design for EUV resists. However, the DGL membrane has an impact for the productivity of EUV scanners due to the transmission loss of EUV light and the necessity of periodic maintenance. The well understanding and control of the outgassing characteristics of metal containing resists may help to improve the productivity of EUV scanner. We consider the outgas evaluation for the resists still useful. For the improvement of resist outgas testing by HPEUV, there are some issues such as the contamination limited regime, the optimization of exposure dose to obtain the measurable contamination film thickness and the detection of minimum amount of metal related outgas species generated. The investigation and improvement for these issues are ongoing. The updates will be presented in the conference. This work was supported by Ministry of Economy, Trade and Industry (METI) and New Energy and Industrial Technology Development Organization (NEDO). [1] Eishi Shiobara, Shinji Mikami, Satoshi Tanaka, International Symposium on EUV Lithography, Hiroshima, Japan, P-RE-01, (2016). [2] Mark van de Kerkhof, Hans Jasper, Leon Levasier, Rudy Peeters, Roderik van Es, Jan-Willem Bosker, Alexander Zdravkov, Egbert Lenderink, Fabrizio Evangelista, Par Broman, Bartosz Bilski, Thorsten Last, Proc. of SPIE Vol. 10143, 101430D (2017). [3] Oktay Yildirim, Elizabeth Buitrago, Rik Hoefnagels, Marieke Meeuwissen, Sander Wuister, Gijsbert Rispens, Anton van Oosten, Paul Derks, Jo Finders, Michaela Vockenhuber, Yasin Ekinci, Proc. of SPIE Vol. 10143, 101430Q (2017).

Band Gap Distortion in Semiconductors Strongly Driven by Intense Mid-Infrared Laser Fields

NASA Astrophysics Data System (ADS)

Kono, J.; Chin, A. H.

2000-03-01

Crystalline solids non-resonantly driven by intense time-periodic electric fields are predicted to exhibit unusual band-gap distortion.(e.g., Y. Yacoby, Phys. Rev. 169, 610 (1968); L.C.M. Miranda, Solid State Commun. 45, 783 (1983); J.Z. Kaminski, Acta Physica Polonica A 83, 495(1993).) Such non-perturbative effects have not been observed to date because of the unavoidable sample damage due to the very high intensity required using conventional lasers ( 1 eV photon energy). Here, we report the first clear evidence of laser-induced bandgap shrinkage in semiconductors under intense mid-infrared (MIR) laser fields. The use of long-wavelength light reduces the required intensity and prohibits strong interband absorption, thereby avoiding the damage problem. The significant sub-bandgap absorption persists only during the existence of the MIR laser pulse, indicating the virtual nature of the effect. We show that this particular example of non-perturbative behavior, known as the dynamical Franz-Keldysh effect, occurs when the effective ponderomotive potential energy is comparable to the photon energy of the applied field. This work was supported by ONR, NSF, JST and NEDO.

Organization Development

ERIC Educational Resources Information Center

Huse, Edgar F.

1978-01-01

Organization Development (OD) is the application of behavioral-science knowledge to enhance an organization's effectiveness and efficiency. This article discusses the evolution of organization development, the basic components of an OD program, typologies of OD interventions, problems with organization development, and organization development in…

[Overview of organic agriculture development.

PubMed

Liu, Xiao Mei; Yu, Hong Jun; Li, Qiang; Jiang, Wei Jie

2016-04-22

This paper introduced the concepts of organic agriculture as defined by different international organizations, origin and theoretical development of organic agriculture, as well as its developing trajectory in China (i.e. a late start followed by rapid growth compared to developed countries). The differences between domestic and international organic agriculture were illustrated by scale, crop types, production standards, inputs and planting techniques. Constraints limiting improvements to organic agriculture in aspects of standards, technology, marketing, certification, environmental pollution, enterprise reputation, and national policies were discussed. Future directions and strategies for developing healthy organic agriculture in China were provided.

Improving Vortex Generators to Enhance the Performance of Air-Cooled Condensers in a Geothermal Power Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manohar S. Sohal

2005-09-01

This report summarizes work at the Idaho National Laboratory to develop strategies to enhance air-side heat transfer in geothermal air-cooled condensers such that it should not significantly increase pressure drop and parasitic fan pumping power. The work was sponsored by the U.S. Department of Energy, NEDO (New Energy and Industrial Technology Development Organization) of Japan, Yokohama National University, and the Indian Institute of Technology, Kanpur, India. A combined experimental and numerical investigation was performed to investigate heat transfer enhancement techniques that may be applicable to largescale air-cooled condensers such as those used in geothermal power applications. A transient heat transfermore » visualization and measurement technique was employed in order to obtain detailed distributions of local heat transfer coefficients on model fin surfaces. Pressure drop measurements were obtained for a variety of tube and winglet configurations using a single-channel flow apparatus that included four tube rows in a staggered array. Heat transfer and pressure drop measurements were also acquired in a separate multiple-tube row apparatus in the Single Blow Test Facility. In addition, a numerical modeling technique was developed to predict local and average heat transfer for these low-Reynolds number flows, with and without winglets. Representative experimental and numerical results were obtained that reveal quantitative details of local finsurface heat transfer in the vicinity of a circular tube with a single delta winglet pair downstream of the cylinder. Heat transfer and pressure-drop results were obtained for flow Reynolds numbers based on channel height and mean flow velocity ranging from 700 to 6500. The winglets were of triangular (delta) shape with a 1:2 or 1:3 height/length aspect ratio and a height equal to 90% of the channel height. Overall mean fin-surface heat transfer results indicate a significant level of heat transfer enhancement (in terms of Colburn j-factor) associated with deployment of the winglets with circular as well as oval tubes. In general, toe-in (common flow up) type winglets appear to have better performance than the toe-out (common flow down) type winglets. Comparisons of heat transfer and pressure drop results for the elliptical tube versus a circular tube with and without winglets are provided. During the course of their independent research, all of the researchers have established that about 10 to 30% enhancement in Colburn j-factor is expected. However, actual increase in heat transfer rate from a heat exchanger employing finned tubes with winglets may be smaller, perhaps on the order of 2 to 5%. It is also concluded that for any specific application, more full-size experimentation is needed to optimize the winglet design for a specific heat exchanger application. If in place of a circular tube, an oval tube can be economically used in a bundle, it is expected that the pressure drop across the tube bundle with the application of vortex generators (winglets) will be similar to that in a conventional circular tube bundle. It is hoped that the results of this research will demonstrate the benefits of applying vortex generators (winglets) on the fins to improve the heat transfer from the air-side of the tube bundle.« less

OSCAR API for Real-Time Low-Power Multicores and Its Performance on Multicores and SMP Servers

NASA Astrophysics Data System (ADS)

Kimura, Keiji; Mase, Masayoshi; Mikami, Hiroki; Miyamoto, Takamichi; Shirako, Jun; Kasahara, Hironori

OSCAR (Optimally Scheduled Advanced Multiprocessor) API has been designed for real-time embedded low-power multicores to generate parallel programs for various multicores from different vendors by using the OSCAR parallelizing compiler. The OSCAR API has been developed by Waseda University in collaboration with Fujitsu Laboratory, Hitachi, NEC, Panasonic, Renesas Technology, and Toshiba in an METI/NEDO project entitled "Multicore Technology for Realtime Consumer Electronics." By using the OSCAR API as an interface between the OSCAR compiler and backend compilers, the OSCAR compiler enables hierarchical multigrain parallel processing with memory optimization under capacity restriction for cache memory, local memory, distributed shared memory, and on-chip/off-chip shared memory; data transfer using a DMA controller; and power reduction control using DVFS (Dynamic Voltage and Frequency Scaling), clock gating, and power gating for various embedded multicores. In addition, a parallelized program automatically generated by the OSCAR compiler with OSCAR API can be compiled by the ordinary OpenMP compilers since the OSCAR API is designed on a subset of the OpenMP. This paper describes the OSCAR API and its compatibility with the OSCAR compiler by showing code examples. Performance evaluations of the OSCAR compiler and the OSCAR API are carried out using an IBM Power5+ workstation, an IBM Power6 high-end SMP server, and a newly developed consumer electronics multicore chip RP2 by Renesas, Hitachi and Waseda. From the results of scalability evaluation, it is found that on an average, the OSCAR compiler with the OSCAR API can exploit 5.8 times speedup over the sequential execution on the Power5+ workstation with eight cores and 2.9 times speedup on RP2 with four cores, respectively. In addition, the OSCAR compiler can accelerate an IBM XL Fortran compiler up to 3.3 times on the Power6 SMP server. Due to low-power optimization on RP2, the OSCAR compiler with the OSCAR API achieves a maximum power reduction of 84% in the real-time execution mode.

Missing in the youth development literature: the organization as host, cage, and promise.

PubMed

Roholt, Ross VeLure; Baizerman, Michael; Rana, Sheetal; Korum, Kathy

2013-01-01

Good, high-quality youth development programs require effective youth organizations. While youth organizations are commonly understood as valuable and supportive of healthy youth development, attention and focus on youth organizations in both scholarship and practice are missing within the youth development field. The authors advocate for a more distinct and clearer focus on youth organizations to foster positive youth development. Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.

22 CFR 203.12 - Cooperative Development Organizations (CDOs).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Cooperative Development Organizations (CDOs). 203.12 Section 203.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REGISTRATION OF PRIVATE VOLUNTARY ORGANIZATIONS (PVOs) § 203.12 Cooperative Development Organizations (CDOs). CDOs are not PVOs for...

22 CFR 203.12 - Cooperative Development Organizations (CDOs).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Cooperative Development Organizations (CDOs). 203.12 Section 203.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REGISTRATION OF PRIVATE VOLUNTARY ORGANIZATIONS (PVOs) § 203.12 Cooperative Development Organizations (CDOs). CDOs are not PVOs for...

Missing in the Youth Development Literature: The Organization as Host, Cage, and Promise

ERIC Educational Resources Information Center

Roholt, Ross VeLure; Baizerman, Michael; Rana, Sheetal; Korum, Kathy

2013-01-01

Good, high-quality youth development programs require effective youth organizations. While youth organizations are commonly understood as valuable and supportive of healthy youth development, attention and focus on youth organizations in both scholarship and practice are missing within the youth development field. The authors advocate for a more…

What an Executive Should Know About Organization Development

ERIC Educational Resources Information Center

Tagliere, Daniel A.

1975-01-01

The author defines organization development (OD) and discusses organization, measurement of success, the role of specialists, the relationship between organization and organization interest illustrated in chart form, and 21 OD strategies. (JB)

Women's Organizations and Development: An Assessment of Capacities for Technical Assistance in Sri Lanka and Thailand. Women in Development.

ERIC Educational Resources Information Center

Stegall, Lael Swinney

A subjective assessment of women's organizations and development in Sri Lanka and Thailand produced specific information about the organizations and suggested ways to improve their development capacities. Personal interviews with nearly 100 organization, government, and agency leaders revealed many similarities between the two countries. In both…

The Effects of an Intergroup Development OD Intervention as Conditioned by the Life Cycle State of Organizations: A Laboratory Experiment.

ERIC Educational Resources Information Center

Randolph, W. Alan; Posner, Barry Z.

1982-01-01

Explored the effectiveness of an intergroup development organization development (OD) intervention at different stages of an organization's life cycle through four simulated organizations. Results suggest intergroup development interventions can be effective at any life stage, but impacts will be felt in different outcome measures and perceptual…

Eco-organic tourism as an element of the sustainable development of territories

NASA Astrophysics Data System (ADS)

Ivanov, D. V.; Ziganshin, I. I.

2018-01-01

Organic agricultural production is an ecologically oriented alternative to traditional agriculture and is aimed at ensuring food and environmental safety of the population and territories. The development of ecological tourism on the basis of organic production farms is considered as a promising direction in the development of regional programs for the sustainable development of territories. Studies have shown that, farms engaged in the production of organic products in the Republic of Tatarstan have a significant potential for the development of eco-organic tourism using elements of the nature protection structure.

Modularity in developmental biology and artificial organs: a missing concept in tissue engineering.

PubMed

Lenas, Petros; Luyten, Frank P; Doblare, Manuel; Nicodemou-Lena, Eleni; Lanzara, Andreina Elena

2011-06-01

Tissue engineering is reviving itself, adopting the concept of biomimetics of in vivo tissue development. A basic concept of developmental biology is the modularity of the tissue architecture according to which intermediates in tissue development constitute semiautonomous entities. Both engineering and nature have chosen the modular architecture to optimize the product or organism development and evolution. Bioartificial tissues do not have a modular architecture. On the contrary, artificial organs of modular architecture have been already developed in the field of artificial organs. Therefore the conceptual support of tissue engineering by the field of artificial organs becomes critical in its new endeavor of recapitulating in vitro the in vivo tissue development. © 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

An Ethnographic Study of a Developing Virtual Organization in Education

ERIC Educational Resources Information Center

Couch, Stephanie R.

2012-01-01

This ethnographic study answers calls for research into the ways that virtual organizations (or innovation-driven collaborative teams) form and develop, what supports and constraints their development, and the leadership models that support the organizations' work. The study examines how a virtual organization emerged from an intersegmental…

The Role of Local Development Organizations in Rural America

ERIC Educational Resources Information Center

Green, Gary Paul; Haines, Anna; Dunn, Adam; Sullivan, Daniel Monroe

2002-01-01

Rural communities rely increasingly on local development organizations (LDOs) to promote economic development. The rise of LDOs has been the source of much debate. Using a national data set that links local governments with development organizations, we contrast the economic development activities, and their outcomes, of local governments and…

The Official Knowledge and Adult Education Agents: An Ethnographic Study of the Adult Education Team of a Local Development-Oriented Nongovernmental Organization in the North of Portugal

ERIC Educational Resources Information Center

Loureiro, Armando Paulo Ferreira; Cristovao, Artur Fernando Arede Correia

2010-01-01

Nongovernmental organizations, particularly those related to development work (local development-oriented nongovernmental organizations; LDNGO), and their agents have been assuming, in Portugal, an important role in the field of adult education. These organizations develop with the State, at the national level, and with supranational institutions…

A theory for classification of health care organizations in the new economy.

PubMed

Vimarlund, Vivian; Sjöberg, Cecilia; Timpka, Toomas

2003-10-01

Most of the available studies into information technology (IT) have been limited to investigating specific issues, such as how IT can support decision makers distributing the information throughout health care organization, or how technology impacts organizational performance. In this study, for use in the planning of information system development projects, a theoretical model for the classification of health care organizations is proposed. We try to reflect the development in the contemporary digital economy by theoretically classifying health care organizations into three types, namely traditional, developing, and flexible. We describe traditional health care organizations as organizations with a centralized system for management and control. In developing health care organizations, IT is spread over the horizontal dimension and is used for coordinating the different parties throughout the organization. Finally, flexible health care organizations are those which work actively with the design of new health care organizational structure while they are designing the information system.

Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

PubMed Central

Modrell, Melinda S; Lyne, Mike; Carr, Adrian R; Zakon, Harold H; Buckley, David; Campbell, Alexander S; Davis, Marcus C; Micklem, Gos; Baker, Clare VH

2017-01-01

The anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating the developmental and evolutionary diversification of different organs and cell types. Zebrafish neuromast development is increasingly well understood, but neither zebrafish nor Xenopus is electroreceptive and our molecular understanding of ampullary organ development is rudimentary. We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefish (Polyodon spathula). Validation of a subset reveals expression in developing ampullary organs of transcription factor genes critical for hair cell development, and genes essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiological and evolutionary links between non-teleost electroreceptors and hair cells. We identify an ampullary organ-specific proneural transcription factor, and candidates for the voltage-sensing L-type Cav channel and rectifying Kv channel predicted from skate (cartilaginous fish) ampullary organ electrophysiology. Overall, our results illuminate ampullary organ development, physiology and evolution. DOI: http://dx.doi.org/10.7554/eLife.24197.001 PMID:28346141

7 CFR 2003.5 - Headquarters organization.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Headquarters organization. 2003.5 Section 2003.5...) ADMINISTRATIVE REGULATIONS ORGANIZATION Functional Organization of the Rural Development Mission Area § 2003.5 Headquarters organization. (a) The Rural Development Headquarters is comprised of: (1) The Office of the Under...

The effectiveness of international development assistance from American organizations to deaf communities in Jamaica.

PubMed

Wilson, Amy T

American organizations bringing assistance to deaf people in developing countries unintentionally create relationships of dependency or oppression rather than relationships of support. Using qualitative methods, the author examined the effectiveness of development assistance provided to the Jamaican Deaf community by two American churches, one American nongovernmental organization, and one U.S. federal agency. Documents were reviewed and observations were made. Interviews were conducted with more than 60 deaf and hearing people involved with the American organizations, the Jamaican organizations, and deaf Jamaican beneficiaries. The author concludes that the Jamaican Deaf community was often excluded in planning, designing, or evaluating programs, and was unsatisfied with the American assistance it received. Results also indicate that the American organizations were poorly prepared to work with the Deaf community. Suggestions for American organizations wishing to strengthen and empower deaf people through development assistance in developing countries are proposed.

Standardization of search methods for guideline development: an international survey of evidence-based guideline development groups.

PubMed

Deurenberg, Rikie; Vlayen, Joan; Guillo, Sylvie; Oliver, Thomas K; Fervers, Beatrice; Burgers, Jako

2008-03-01

Effective literature searching is particularly important for clinical practice guideline development. Sophisticated searching and filtering mechanisms are needed to help ensure that all relevant research is reviewed. To assess the methods used for the selection of evidence for guideline development by evidence-based guideline development organizations. A semistructured questionnaire assessing the databases, search filters and evaluation methods used for literature retrieval was distributed to eight major organizations involved in evidence-based guideline development. All of the organizations used search filters as part of guideline development. The medline database was the primary source accessed for literature retrieval. The OVID or SilverPlatter interfaces were used in preference to the freely accessed PubMed interface. The Cochrane Library, embase, cinahl and psycinfo databases were also frequently used by the organizations. All organizations reported the intention to improve and validate their filters for finding literature specifically relevant for guidelines. In the first international survey of its kind, eight major guideline development organizations indicated a strong interest in identifying, improving and standardizing search filters to improve guideline development. It is to be hoped that this will result in the standardization of, and open access to, search filters, an improvement in literature searching outcomes and greater collaboration among guideline development organizations.

Evolution of the organizer and the chordate body plan

NASA Technical Reports Server (NTRS)

Gerhart, J.

2001-01-01

The discovery of the organizer by Spemann and Mangold in 1924 raised two kinds of questions: those about the means of patterning the chordate body axis and those about the mechanisms of cell determination by induction. Some researchers, stressing the second, have suggested over the years that the organizer is poorly named and doesn't really organize because inducers act permissively, because they are not unique to the organizer, and because multipotent responsive cells develop complex local differentiations under artificial conditions. Furthermore, with the discovery of meso-endoderm induction in 1969, the possibility arose that this earlier induction generates as much organization as, or more than, does the organizer itself. Evidence is summarized in this article that the organizer does fulfill its title with regard to pattern formation: it adds greatly to embryonic organization by providing information about time, place, scale, and orientation for development by nearby members of the large multipotent competence groups surrounding the organizer. Embryos having smaller or larger organizers due to experimental intervention develop defective axial organization. Without an organizer the embryo develops no body axis and none of the four chordate characters: the notochord, gill slits, dorsal hollow nerve chord, and post-anal tail. For normal axis formation, the organizer's tripartite organization is needed. Each part differs in inducers, morphogenesis, and self-differentiation. The organizer is a trait of development of all members of the chordate phylum. In comparison to hemichordates, which constitute a phylum with some similarities to chordates, the chordamesoderm part is unique to the chordate organizer (the trunk-tail organizer). Its convergent extension displaces the gastrula posterior pole from alignment with the animal-vegetal axis and generates a new anteroposterior axis orthogonal to this old one. Once it has extended to full length, its signaling modifies the dorsoventral dimension. This addition to the organizer is seen as a major event in chordate evolution, bringing body organization beyond that achieved by oocyte organization and meso-endoderm induction in other groups.

Maturity Level of Organizations Integrating Organizational Development with Human Resource Development.

ERIC Educational Resources Information Center

Herman, Jerry J.; Herman, Janice L.

1994-01-01

Future organizations must integrate their human-resource development requirements with organizational development requirements to survive and prosper. A totally integrated systems model will feature 10 crucial elements. Leaders must understand that their organizations pass through developmental stages (from infancy to maturity); at each stage,…

Latest development of legal regulations of organ transplant in China.

PubMed

Ding, Chunyan

2008-12-01

Organ transplant practice has developed greatly in last two decades in China. In response to the practical need, the State Council released the Regulations on Human Organ Transplant 2007, replacing the previous Interim Provisions on Administration of Clinical Application of Human Organ Transplant Technology 2006. This article first examines the latest development of legal regulations of organ transplant by comparing the differences between the two pieces of legislation. It then analyzes the impact of the new rules set forth in the 2007 Regulations upon three problems existing in the current organ transplant practice, that is, organ procurement from executed prisoners, organ trade, and organ tourism. The article finally discusses the deficiencies of the 2007 Regulations, which are supposed to be remedied in the next legal reform.

Adult Educators' Perceptions of Their Organization Promoting Learning Practices and Culture: A Caribbean Law Enforcement Context

ERIC Educational Resources Information Center

Hunter-Johnson, Yvonne; Closson, Rosemary

2012-01-01

Many organizations, whether private or public, invest extensively in training and development. Such investment in training and development does not guarantee that the organization is perceived as a learning organization. This study examined law enforcement adult educators' (training facilitators') perceptions of their organization promoting…

78 FR 42084 - Cooperative Agreement to Support the World Trade Organization's Standards and Trade Development...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-15

... Organization for Animal Health, World Bank, World Health Organization (WHO) and the WTO. The STDF supports...] Cooperative Agreement to Support the World Trade Organization's Standards and Trade Development Facility... cooperative agreement in fiscal year 2013 (FY 2013) to the World Trade Organization's (WTO) Standards and...

The System Dynamics Model for Development of Organic Agriculture

NASA Astrophysics Data System (ADS)

Rozman, Črtomir; Škraba, Andrej; Kljajić, Miroljub; Pažek, Karmen; Bavec, Martina; Bavec, Franci

2008-10-01

Organic agriculture is the highest environmentally valuable agricultural system, and has strategic importance at national level that goes beyond the interests of agricultural sector. In this paper we address development of organic farming simulation model based on a system dynamics methodology (SD). The system incorporates relevant variables, which affect the development of the organic farming. The group decision support system (GDSS) was used in order to identify most relevant variables for construction of causal loop diagram and further model development. The model seeks answers to strategic questions related to the level of organically utilized area, levels of production and crop selection in a long term dynamic context and will be used for simulation of different policy scenarios for organic farming and their impact on economic and environmental parameters of organic production at an aggregate level.

Limits of the Learning Organization: A Critical Look.

ERIC Educational Resources Information Center

Fenwick, Tara J.

The development of the "learning organization" may be traced to three converging trends: the tradition of organizational development; economic shifts to globalization, deregulation, and information-based industry; and total quality management. Learning organizations are generally characterized as follows: organizations that create…

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

PubMed Central

Ager, Ann

2017-01-01

The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer cells that initiate and sustain the development of lymphoid tissues. In adults, the blood vessels are structurally distinct from those in other organs due to the requirement for high levels of lymphocyte recruitment under non-inflammatory conditions. In lymph nodes (LNs) and Peyer’s patches, high endothelial venules (HEVs) especially adapted for lymphocyte trafficking form a spatially organized network of blood vessels, which controls both the type of lymphocyte and the site of entry into lymphoid tissues. Uniquely, HEVs express vascular addressins that regulate lymphocyte entry into lymphoid organs and are, therefore, critical to the function of lymphoid organs. Recent studies have demonstrated important roles for CD11c+ dendritic cells in the induction, as well as the maintenance, of vascular addressin expression and, therefore, the function of HEVs. Tertiary lymphoid organs (TLOs) are HEV containing LN-like structures that develop inside organized tissues undergoing chronic immune-mediated inflammation. In autoimmune lesions, the development of TLOs is thought to exacerbate disease. In cancerous tissues, the development of HEVs and TLOs is associated with improved patient outcomes in several cancers. Therefore, it is important to understand what drives the development of HEVs and TLOs and how these structures contribute to pathology. In several human diseases and experimental animal models of chronic inflammation, there are some similarities between the development and function of HEVs within LN and TLOs. This review will summarize current knowledge of how hemopoietic cells with lymphoid tissue-inducing, HEV-inducing, and HEV-maintaining properties are recruited from the bloodstream to induce the development and control the function of lymphoid organs. PMID:28217126

24 CFR 4100.2 - General organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false General organization. 4100.2 Section 4100.2 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) NEIGHBORHOOD REINVESTMENT CORPORATION ORGANIZATION AND CHANNELING OF FUNCTIONS § 4100.2 General...

Becoming organisms: the organisation of development and the development of organisation.

PubMed

de la Rosa, Laura Nuño

2010-01-01

Despite the radical importance of embryology in the development of organicism, developmental biology remains philosophically underexplored as a theoretical and empirical resource to clarify the nature of organisms. This paper discusses how embryology can help develop the organisational definition of the organism as a differentiated, functionally integrated, and autonomous system. I distinguish two conceptions of development in the organisational tradition that yield two different conceptions of the organism: the life-history view claims that organisms can be considered as such during their whole ontogeny; the constitutive view distinguishes two periods in the life history, a period of generation and a period of self-maintenance of a constitutive organisation. Arguing in favour of the constitutive view, it will be claimed that the organisational criteria for the definition of organism (i.e., differentiation, functional integration, and autonomy) can only be applied to the developmental system when it has entered the period of self-maintenance of a constitutive organisation. Under the light of current research in developmental biology, it is possible to make explicit how organisms come to be as organisms. To this end, I explore key ontogenetic events that help us clarify the core aspects of animal organisation and allow us to identify the developmental stage that marks the ontological transition between an organism in potency and an organism in actuality. The structure of this ontogenetic unfolding parallels the conceptual structure of the very notion of organism; the generation of the being of a particular organism parallels its definition.

The Construction and Development of Indicators of Learning Organization at Higher Educational Institutions Emphasizing Graduate Production and Social Development

ERIC Educational Resources Information Center

Hanrin, Chanwit; Sri-Amphai, Pissamai; Ruangmontri, Karn; Namwan, Tharinthorn

2011-01-01

The Purposes of this research were to construct and develop indicators of learning organization at higher educational institutions emphasize graduate production and social development, and to test the congruence of the structural model of the indicators of learning organization at higher educational institutions emphasizing graduate production and…

Organization Development in Mental Health Services.

ERIC Educational Resources Information Center

Glaser, Edward M.; Backer, Thomas E.

1979-01-01

The term "organization development" (OD) encompasses techniques developed to facilitate communication and collaborative problem solving in work groups. This discussion focuses on defining OD, describing its current use in mental health and human service organizations, and assessing potential payoffs and disadvantages of implementing OD programs in…

Organ printing: from bioprinter to organ biofabrication line.

PubMed

Mironov, Vladimir; Kasyanov, Vladimir; Markwald, Roger R

2011-10-01

Organ printing, or the layer by layer additive robotic biofabrication of functional three-dimensional tissue and organ constructs using self-assembling tissue spheroid building blocks, is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. It is increasingly obvious that similar well-established industries implement automated robotic systems on the path to commercial translation and economic success. The use of robotic bioprinters alone however is not sufficient for the development of large industrial scale organ biofabrication. The design and development of a fully integrated organ biofabrication line is imperative for the commercial translation of organ printing technology. This paper presents recent progress and challenges in the development of the essential components of an organ biofabrication line. Copyright © 2011 Elsevier Ltd. All rights reserved.

Recent developments in water quality monitoring for Space Station reclaimed wastewaters

NASA Technical Reports Server (NTRS)

Small, John W.; Verostko, Charles E.; Linton, Arthur T.; Burchett, Ray

1987-01-01

This paper discusses the recent developments in water quality monitoring for Space Station reclaimed wastewaters. A preprototype unit that contains an ultraviolet absorbance organic carbon monitor integrated with pH and conductivity sensors is presented. The preprototype has provisions for automated operation and is a reagentless flow-through system without any gas/liquid interfaces. The organic carbon monitor detects by utraviolet absorbance the organic impurities in reclaimed wastewater which may be correlated to the organic carbon content of the water. A comparison of the preprototype organic carbon detection values with actual total organic carbon measurements is presented. The electrolyte double junction concept for the pH sensor and fixed electrodes for both the pH and conductivity sensors are discussed. In addition, the development of a reagentless organic carbon analyzer that incorporates ultraviolet oxidation and infrared detection is presented. Detection sensitivities, hardware development, and operation are included.

Organic livestock production in Uganda: potentials, challenges and prospects.

PubMed

Nalubwama, Sylvia Muwanga; Mugisha, Anthony; Vaarst, Mette

2011-04-01

Development in organic farming has been stimulated by farmers and consumers becoming interested in healthy food products and sustainable environment. Organic agriculture is a holistic production management system which is based on the principles of health, ecology, care, and fairness. Organic development in Uganda has focused more on the crop sector than livestock sector and has primarily involved the private sector, like organic products export companies and non-governmental organizations. Agriculture in Uganda and many African countries is predominantly traditional, less mechanized, and is usually associated with minimum use of chemical fertilizers, pesticides, and drugs. This low external input agriculture also referred to as "organic by default" can create basis for organic farming where agroecological methods are introduced and present an alternative in terms of intensification to the current low-input/low-output systems. Traditional farming should not be confused with organic farming because in some cases, the existing traditional practices have consequences like overstocking and less attention to soil improvement as well as to animal health and welfare, which is contrary to organic principles of ecology, fairness, health, and care. Challenges of implementing sustainable organic practices in the Ugandan livestock sector threaten its future development, such as vectors and vector-borne diseases, organic feed insufficiency, limited education, research, and support to organic livestock production. The prospects of organic livestock development in Uganda can be enhanced with more scientific research in organic livestock production under local conditions and strengthening institutional support.

Development of the nasal chemosensory organs in two terrestrial anurans: the directly developing frog, Eleutherodactylus coqui (Anura: Leptodactylidae), and the metamorphosing toad, Bufo americanus (Anura: Bufonidae).

PubMed

Jermakowicz, Walter J; Dorsey, David A; Brown, Amy L; Wojciechowski, Karen; Giscombe, Claudette L; Graves, Brent M; Summers, Cliff H; Ten Eyck, Gary R

2004-08-01

Nearly all vertebrates possess an olfactory organ but the vomeronasal organ is a synapomorphy for tetrapods. Nevertheless, it has been lost in several groups of tetrapods, including aquatic and marine animals. The present study examines the development of the olfactory and vomeronasal organs in two terrestrial anurans that exhibit different developmental modes. This study compares the development of the olfactory and vomeronasal organs in metamorphic anurans that exhibit an aquatic larva (Bufo americanus) and directly developing anurans that have eliminated the tadpole (Eleutherodactylus coqui). The olfactory epithelium in larval B. americanus is divided into dorsal and ventral branches in the rostral and mid-nasal regions. The larval olfactory pattern in E. coqui has been eliminated. Ontogeny of the olfactory system in E. coqui embryos starts to vary substantially from the larval pattern around the time of operculum development, the temporal period when the larval stage is hypothesized to have been eliminated. The nasal anatomy of the two frogs does not appear morphologically similar until the late stages of embryogenesis in E. coqui and the terminal portion of metamorphosis in B. americanus. Both species and their respective developing offspring, aquatic tadpoles and terrestrial egg/embryos, possess a vomeronasal organ. The vomeronasal organ develops at mid-embryogenesis in E. coqui and during the middle of the larval period in B. americanus, which is relatively late for neobatrachians. Development of the vomeronasal organ in both frogs is linked to the developmental pattern of the olfactory system. This study supports the hypothesis that the most recent common ancestor of tetrapods possessed a vomeronasal organ and was aquatic, and that the vomeronasal organ was retained in the Amphibia, but lost in some other groups of tetrapods, including aquatic and marine animals. Copyright 2004 Wiley-Liss, Inc.

The development of artificial organs and prostheses worldwide and in the Ottoman Empire.

PubMed

Birdane, Leman; Cingi, Cemal; Elçioğlu, Ömür; Muluk, Nuray Bayar

2016-08-01

An artificial organ or prosthesis is a man-made device that is implanted or integrated into a human to replace a natural organ. There were many historical steps in the development of artificial organs and prostheses. New surgical techniques, the development of prosthetic materials and the creative ideas of engineers led to progress in this field. © The European Society of Cardiology 2014.

[Classification and organization technologies in public health].

PubMed

Filatov, V B; Zhiliaeva, E P; Kal'fa, Iu I

2000-01-01

The authors discuss the impact and main characteristics of organization technologies in public health and the processes of their development and evaluation. They offer an original definition of the notion "organization technologies" with approaches to their classification. A system of logical bases is offered, which can be used for classification. These bases include the level of organization maturity and stage of development of organization technology, its destination to a certain level of management, type of influence and concentration of trend, mechanism of effect, functional group, and methods of development.

The Stigma of Failure in Organizations

DTIC Science & Technology

2008-01-15

divisions, suggests why the stigma of failure may not always apply in public-sector organizations, and suggests why the development of entrepreneurship ...within organizations may be path- dependent. 14. SUBJECT TERMS Corporate entrepreneurship , stigma of failure 15. NUMBER OF PAGES 59 16. PRICE...of failure may not always apply in public-sector organizations, and suggests why the development of entrepreneurship within organizations may be

Organic and Hybrid Organic Solid-State Photovoltaic Materials and Devices

DTIC Science & Technology

2014-03-06

Microscopy Research, 2012, 7, 158-169. Organic photovoltaic materials, hybrid organic devices, solar cells 6 1 FINAL TECHNICAL REPORT 1... hybrids have potential applications in solar cells and may thus provide mobile energy sources for aircraft and soldier technologies. Modeling and...modeling and simulation developed in this project are encouraging further development. 2. Technical Activities Hybrid organic solar cells are an

Balanced scorecard as a framework for driving performance in managed care organizations.

PubMed

Sahney, V K

1998-01-01

Managed care organizations in a highly competitive environment constantly face the pressure of improving their financial performance. At the same time, customers of the organization expect the organization to deliver high-quality outcomes and improve customer service. Payers expect the organization to develop innovative new products to meet their needs. This article presents an approach called "Balanced Scorecard" for measurement, development of strategy, and performance improvement in a managed care organization.

Three-Dimensional Printing of Tissue/Organ Analogues Containing Living Cells.

PubMed

Park, Jeong Hun; Jang, Jinah; Lee, Jung-Seob; Cho, Dong-Woo

2017-01-01

The technical advances of three-dimensional (3D) printing in the field of tissue engineering have enabled the creation of 3D living tissue/organ analogues. Diverse 3D tissue/organ printing techniques with computer-aided systems have been developed and used to dispose living cells together with biomaterials and supporting biochemicals as pre-designed 3D tissue/organ models. Furthermore, recent advances in bio-inks, which are printable hydrogels with living cell encapsulation, have greatly enhanced the versatility of 3D tissue/organ printing. Here, we introduce 3D tissue/organ printing techniques and biomaterials that have been developed and widely used thus far. We also review a variety of applications in an attempt to repair or replace the damaged or defective tissue/organ, and develop the in vitro tissue/organ models. The potential challenges are finally discussed from the technical perspective of 3D tissue/organ printing.

Arthropod community organization and development in pear

NASA Astrophysics Data System (ADS)

Gut, Larry J.; Liss, W. J.; Westigard, P. H.

1991-01-01

Arthropod communities in pear are conceptualized as hierarchically organized systems in which several levels of organization or subsystems can be recognized between the population level and the community as a whole. An individual pear tree is taken to be the community habitat with arthropod subcommunities developing on leaf, fruit, and wood subcommunity habitats. Each subcommunity is composed of trophically organized systems of populations. Each system of populations is comprised of a functional group or guild of phytophagous arthropods that use the habitat primarily for feeding but also for overwintering or egg deposition, and associated groups of specialized predators, parasitoids, and hyperparasitoids. Several species move from one subcommunity to another during the course of community development and thus integrate community subsystems. Community development or change in organization through time is conceptualized as being jointly determined by the development of the habitat and the organization of the species pool. The influence of habitat development on community development within a species pool is emphasized in this research. Seasonal habitat development is expressed as change in the kinds and biomasses of developmental states of wood, leaf, and fruit subcommunity habitats. These changes are accompanied by changes in the kinds, biomasses, and distributions of associated community subsystems.

Re-evaluating the functional landscape of the cardiovascular system during development

PubMed Central

Takada, Norio; Omae, Madoka; Sagawa, Fumihiko; Chi, Neil C.; Endo, Satsuki; Kozawa, Satoshi

2017-01-01

ABSTRACT The cardiovascular system facilitates body-wide distribution of oxygen, a vital process for the development and survival of virtually all vertebrates. However, the zebrafish, a vertebrate model organism, appears to form organs and survive mid-larval periods without a functional cardiovascular system. Despite such dispensability, it is the first organ to develop. Such enigma prompted us to hypothesize other cardiovascular functions that are important for developmental and/or physiological processes. Hence, systematic cellular ablations and functional perturbations were performed on the zebrafish cardiovascular system to gain comprehensive and body-wide understanding of such functions and to elucidate the underlying mechanisms. This approach identifies a set of organ-specific genes, each implicated for important functions. The study also unveils distinct cardiovascular mechanisms, each differentially regulating their expressions in organ-specific and oxygen-independent manners. Such mechanisms are mediated by organ-vessel interactions, circulation-dependent signals, and circulation-independent beating-heart-derived signals. A comprehensive and body-wide functional landscape of the cardiovascular system reported herein may provide clues as to why it is the first organ to develop. Furthermore, these data could serve as a resource for the study of organ development and function. PMID:28982700

Re-evaluating the functional landscape of the cardiovascular system during development.

PubMed

Takada, Norio; Omae, Madoka; Sagawa, Fumihiko; Chi, Neil C; Endo, Satsuki; Kozawa, Satoshi; Sato, Thomas N

2017-11-15

The cardiovascular system facilitates body-wide distribution of oxygen, a vital process for the development and survival of virtually all vertebrates. However, the zebrafish, a vertebrate model organism, appears to form organs and survive mid-larval periods without a functional cardiovascular system. Despite such dispensability, it is the first organ to develop. Such enigma prompted us to hypothesize other cardiovascular functions that are important for developmental and/or physiological processes. Hence, systematic cellular ablations and functional perturbations were performed on the zebrafish cardiovascular system to gain comprehensive and body-wide understanding of such functions and to elucidate the underlying mechanisms. This approach identifies a set of organ-specific genes, each implicated for important functions. The study also unveils distinct cardiovascular mechanisms, each differentially regulating their expressions in organ-specific and oxygen-independent manners. Such mechanisms are mediated by organ-vessel interactions, circulation-dependent signals, and circulation-independent beating-heart-derived signals. A comprehensive and body-wide functional landscape of the cardiovascular system reported herein may provide clues as to why it is the first organ to develop. Furthermore, these data could serve as a resource for the study of organ development and function. © 2017. Published by The Company of Biologists Ltd.

77 FR 37374 - Nominations for Members of the National Organic Standards Board

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... is required to establish an NOSB. The purpose of the NOSB is to assist in the development of a... practical experience in the organic community; demonstrated experience in the development of public policy... organizations; participation in standards development or involvement in educational outreach activities; a...

Human Development in Organizations - MGT 334: Higher Education Course Monograph No. 4.

ERIC Educational Resources Information Center

Steers, Richard M.

This is a description of a training course for human services personnel which covers a major function of comprehensive manpower development programs. Human Development in Organizations is a course for nonmanagement majors which surveys the developmental process of employees in complex organizations both from managerial and psychological…

To go or not to go organic: what choice for Pacific island countries?

PubMed

Fuatai, Lafitai; Stewart, Cortney

2002-09-01

There are arguments for and against organic agriculture. The paper looks at the impact of changes and development, the need for sustainable development, organic farming as a viable alternative, organic certification and concluding thoughts on why organic farming makes sense. To go organic does not necessarily mean that organic products are totally free of chemical pesticides but they have a lower pesticide residue. Organic certification, a process guarantee not a product guarantee, becomes necessary if a farmer has to sell organic food products locally (to tourists) or export overseas. For Pacific organic producers, the biggest obstacle lies with certification costs and initial investments in research and extension to educate consumers and farmers about organic agriculture organic methods.

Richard Schrock, Robert Grubbs, and Metathesis Method in Organic Synthesis

Science.gov Websites

Organic Synthesis Resources with Additional Information Richard R. Schrock of the Massachusetts Institute Nobel Prize in Chemistry "for the development of the metathesis method in organic synthesis" ] Chauvin, Grubbs and Schrock "for the development of the metathesis method in organic synthesis,"

Managing an "Organistically-Oriented" School Intervention Program.

ERIC Educational Resources Information Center

Barrilleaux, Louis E.; Schermerhorn, John R., Jr.

An "organic" relationship between change agents and clients is a well-popularized goal in recent literature on planned change and organization development. There is, however, a dearth of literature on how to manage change programs under parameters set by this organic value. This paper examines one school organization development program for the…

College and Career Development Organizer

ERIC Educational Resources Information Center

National High School Center, 2012

2012-01-01

The National High School Center has created a college and career development organizer to synthesize and organize an increasingly complicated and crowded field of college and career readiness initiatives. The organizer, composed of three strands, can be used to map the efforts of state education agencies (SEAs) and local education agencies (LEAs)…

Describing the Climate of Student Organizations: The Student Organization Environment Scales.

ERIC Educational Resources Information Center

Winston, Roger B., Jr.; Bledsoe, Tyrone; Goldstein, Adam R.; Wisbey, Martha E.; Street, James L.; Brown, Steven R.; Goyen, Kenneth D.; Rounds, Linda E.

1997-01-01

Using M. R. Weisbord's model of organizational diagnosis, researchers developed the Student Organization Environment Scales to measure students' perceptions of the psychosocial environment or climate of college student organizations. Development of the instrument is described and estimates of its reliability and validity are reported. Describes…

Towards Healthy Organizations: The Use of Organization Development in Academic Libraries

ERIC Educational Resources Information Center

Parsch, Janet H.; Baughman, M. Sue

2010-01-01

Two surveys assess use of organization development (OD) in Association of Research Libraries. Analysis presents organizational, deans', and staff professionals' perspectives on OD use. The study is the first broad analysis of academic library OD use and supports the concept of the "healthy organization." (Contains 12 tables.)

Perspective: the potential of student organizations for developing leadership: one school's experience.

PubMed

Veronesi, Michael C; Gunderman, Richard B

2012-02-01

Leadership development is vital to the future of medicine. Some leadership development may take place through the formal curriculum of the medical school, yet extracurricular activities, such as student government and affiliated student organizations, can provide additional, highly valuable leadership development opportunities. These organizations and their missions can serve as catalysts for students to work with one another, with the faculty and administration of the medical school, with the community, and with local, regional, and national organizations. The authors have organized this discussion of the leadership development potential of student organizations around six important principles of leadership: ownership, experience, efficacy, sense of community, service learning, and peer-to-peer mentoring. They provide practical examples of these leadership principles from one institution. They do not presume that the school is unique, but they do believe their practical examples help to illuminate the potential of extracurricular programs for enhancing the leadership capabilities of future physicians. In addition, the authors use their examples to demonstrate how the medical school, its surrounding community, and the profession of medicine can benefit from promoting leadership through student organizations.

Critical Care Organizations: Building and Integrating Academic Programs.

PubMed

Moore, Jason E; Oropello, John M; Stoltzfus, Daniel; Masur, Henry; Coopersmith, Craig M; Nates, Joseph; Doig, Christopher; Christman, John; Hite, R Duncan; Angus, Derek C; Pastores, Stephen M; Kvetan, Vladimir

2018-04-01

Academic medical centers in North America are expanding their missions from the traditional triad of patient care, research, and education to include the broader issue of healthcare delivery improvement. In recent years, integrated Critical Care Organizations have developed within academic centers to better meet the challenges of this broadening mission. The goal of this article was to provide interested administrators and intensivists with the proper resources, lines of communication, and organizational approach to accomplish integration and Critical Care Organization formation effectively. The Academic Critical Care Organization Building section workgroup of the taskforce established regular monthly conference calls to reach consensus on the development of a toolkit utilizing methods proven to advance the development of their own academic Critical Care Organizations. Relevant medical literature was reviewed by literature search. Materials from federal agencies and other national organizations were accessed through the Internet. The Society of Critical Care Medicine convened a taskforce entitled "Academic Leaders in Critical Care Medicine" on February 22, 2016 at the 45th Critical Care Congress using the expertise of successful leaders of advanced governance Critical Care Organizations in North America to develop a toolkit for advancing Critical Care Organizations. Key elements of an academic Critical Care Organization are outlined. The vital missions of multidisciplinary patient care, safety, and quality are linked to the research, education, and professional development missions that enhance the value of such organizations. Core features, benefits, barriers, and recommendations for integration of academic programs within Critical Care Organizations are described. Selected readings and resources to successfully implement the recommendations are provided. Communication with medical school and hospital leadership is discussed. We present the rationale for critical care programs to transition to integrated Critical Care Organizations within academic medical centers and provide recommendations and resources to facilitate this transition and foster Critical Care Organization effectiveness and future success.

Tongue and taste organ development in the ontogeny of direct-developing salamander Plethodon cinereus (Lissamphibia: Plethodontidae).

PubMed

Budzik, Karolina A; Żuwała, Krystyna; Kerney, Ryan

2016-07-01

The latest research on direct developing caecilian and anuran species indicate presence of only one generation of taste organs during their ontogeny. This is distinct from indirect developing batrachians studied thus far, which possess taste buds in larvae and anatomically distinct taste discs in metamorphs. This study is a description of the tongue and taste organ morphology and development in direct developing salamander Plethodon cinereus (Plethodontidae) using histology and electron microscopy techniques. The results reveal two distinct stages tongue morphology (primary and secondary), similar to metamorphic urodeles, although only one stage of taste organ morphology. Taste disc sensory zones emerge on the surface of the oropharyngeal epithelium by the end of embryonic development, which coincides with maturation of the soft tongue. Taste organs occur in the epithelium of the tongue pad (where they are situated on the dermal papillae), the palate and the inner surface of the mandible and the maxilla. Plethodon cinereus embryos only possess taste disc type taste organs. Similar to the direct developing anuran Eleutherodactylus coqui (Eleutherodactylidae), these salamanders do not recapitulate larval taste bud morphology as an embryo. The lack of taste bud formation is probably a broadly distributed feature characteristic to direct developing batrachians. J. Morphol. 277:906-915, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Forest products research and development organizations : organization, governance, and measures of performance in a worldwide setting

Treesearch

Paul V. Ellefson; M.A. Kilgore; Kenneth E. Skog; Christopher D. Risbrudt

2007-01-01

The ability of forest products research and development organizations to contribute to a nation’s well-being requires that they be well organized, effectively managed, and held to high standards of performance. In order to obtain a better understanding of how such organizations are structured and administered, and how they judge organizational performance, a review of...

Professional Teacher Education Module Series. Assist Student Vocational Organization Members in Developing and Financing a Yearly Program of Activities, Module H-4 of Category H--Student Vocational Organization.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This fourth in a series of six learning modules on student vocational organizations is designed to assist secondary and postsecondary vocational teachers in developing the competency to assist students in planning a student organization's (or club's) yearly program of activities, in properly managing organization finances, in selecting…

Essence of Black Colleges in Community Development.

ERIC Educational Resources Information Center

Technical Assistance Consortium To Improve Coll. Services, Washington, DC.

The response of black colleges and universities in the area of community development are discussed in relation to management and organization development, telecommunication, human resource development, educational innovations, and environmental services. Management and organization development encompasses small business development, public service…

Model of Learning Organizational Development of Primary School Network under the Office of Basic Education Commission

ERIC Educational Resources Information Center

Sai-rat, Wipa; Tesaputa, Kowat; Sriampai, Anan

2015-01-01

The objectives of this study were 1) to study the current state of and problems with the Learning Organization of the Primary School Network, 2) to develop a Learning Organization Model for the Primary School Network, and 3) to study the findings of analyses conducted using the developed Learning Organization Model to determine how to develop the…

The Dialectical Development of "Storytelling" Learning Organizations: A Case Study of a Public Research University

ERIC Educational Resources Information Center

Hillon, Yue Cai; Boje, David M.

2017-01-01

Purpose: Calls for dialectical learning process model development in learning organizations have largely gone unheeded, thereby limiting conceptual understanding and application in the field. This paper aims to unify learning organization theory with a new understanding of Hegelian dialectics to trace the development of the storytelling learning…

Supporting Residential Student Organization Advisers: A 21st Century Adviser Training and Development Program

ERIC Educational Resources Information Center

Shapiro, Cory Adam

2012-01-01

The purpose for this doctoral action research study was to discover if and how an updated training and development curriculum benefited residential student organization advisers at Arizona State University (ASU). Eleven advisers of residential student organizations completed a pilot training and development program and agreed to participate in a…

A Procedure for Strengthening Organizational Effectiveness.

ERIC Educational Resources Information Center

Midwest Organization Development Network, Cleveland, OH.

This booklet attempts to give a brief overview of the nature of organization development (OD). It describes the role of the professional organization development specialist, how he functions, and what he tries to do in the client system. It also describes the purposes of the Midwest Organization Development Network, a nonprofit association of OD…

Characteristics and Professional Concerns of Organization Development Practitioners.

ERIC Educational Resources Information Center

Patten, Thomas H., Jr.; And Others

A study was undertaken of organization development (OD) programs, from the point of view of the organization members who plan and conduct them, to gain information for meaningful planning by the American Society for Training and Development (ASTD). A questionnaire was returned by 103 of 450 randomly selected OD practitioners. Most respondents had…

Collection Development Organization and Committees. SPEC Kit 11.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit focuses on information that is useful for starting a collection development program. It contains 7 position descriptions, 10 documents on the role of committees, 4 organization charts, 5 documents on the organization of functions, and an analysis of a Systems and Procedures Exchange Center (SPEC) collection development survey. The survey,…

[An increase in efficiency of adaptations and a weakening of organism protective reactions in the process of biological evolution].

PubMed

Ivanov, K P

2014-01-01

The main direction of evolution of living organisms is development of the central nervous system and sense organ, an increase of energy exchange development of homoiothermia, development of the more and more complex forms of behavior, an increase in energy expenditure in connection with an increase of the organism activity, and development of adaptation to the habitat. Such fundamental processes were subjected and have been subjected to numerous studies and discussions. However, in different animals there exist different species peculiarities of evolution of physiological functions, from which finally formed are fundamental evolutionary processes. We studied some of these specific processes by dividing them into two categories. The first category is "Increase of efficiency of adaptation" in development of biological evolution. By this term we mean development of amazing by perfection specific physiological mechanisms of adaptive character. The second category is "Weakening of protective organism reactions". By this we understand disturbance of protective mechanisms of the organism immune system, discoordination of movement of leukocytes along microvessels, the absence of efficient collateral circulation in brain and in heart, etc.

Chromatin states and nuclear organization in development--a view from the nuclear lamina.

PubMed

Mattout, Anna; Cabianca, Daphne S; Gasser, Susan M

2015-08-25

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.

Youth Organizing: From Youth Development to School Reform

ERIC Educational Resources Information Center

Warren, Mark R.; Mira, Meredith; Nikundiwe, Thomas

2008-01-01

Over the past twenty years, youth organizing has grown across the country. Through organizing, young people identify issues of concern and mobilize their peers to build action campaigns to achieve their objectives. Youth organizing has been appreciated for its contributions to youth and community development. The authors use two case studies to…

Diagnosing Organization-Environment "Fit": Implications for Organization Development

ERIC Educational Resources Information Center

Gabarro, John J.

1974-01-01

This article has attempted to: (1) describe several dimensions of organization-environment fit; (2) describe some concepts which can be used in diagnosing the degree to which a school system's organization matches the demands and needs of its environment; (3) present some implications of such a diagnosis for OD [organizational development]…

Creating Standards for Student Organizations at Public Institutions in Colorado

ERIC Educational Resources Information Center

Damania, Nicky Pessi

2012-01-01

At institutions of higher education, the environment for developing student organizations has been less than optimum due to a lack of development of effective and efficient standards for these organizations. Even though there are tools for improving organizations, there are no set standards for their operation and governance to ignite leadership…

Incentives for organ donation in the United States: feasible alternative or forthcoming apocalypse?

PubMed

Hippen, Benjamin; Matas, Arthur

2009-04-01

Several factors have generated interest in proposals to offer incentives in exchange for kidneys from living donors, including the growing shortage of available organs, the apparent asymptote of traditional means of organ procurement, and the intimate link between the inadequacies of organ procurement policies in developed countries with the flourishing of underground organ trafficking in developing countries. Herein, we review the scope and dimensions of the growing shortage of organs in the United States, with attention to how each of the proposed solutions to same has proven insufficient. With special attention to the concerns leveled by Gabriel Danovitch in his 'Open Letter,' we conclude that each of his concerns are unfounded, and offer a prospectus on how a trial of such systems might be pursued in the United States. The failure of current approaches to organ procurement in the United States and other developed countries has led to unnecessary suffering and death, with morally unacceptable consequences for developing countries. For these reasons, a structured trial of incentives for organ procurement in the United States is a moral imperative.

Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract.

PubMed

Rangel-Moreno, Javier; Carragher, Damian; Randall, Troy D

2007-01-01

Secondary lymphoid organs are strategically placed to recruit locally activated antigen presenting cells (APCs) as well as naïve, recirculating T and B cells. The structure of secondary lymphoid organs - separated B and T zones, populations of specialized stromal cells, high endothelial venules and lymphatic vessles - has also evolved to maximize encounters between APCs and lymphocytes and to facilitate the expansion and differentiation of antigen-stimulated T and B cells. Many of the general mechanisms that govern the development and organization of secondary lymphoid organs have been identified over the last decade. However, the specific cellular and molecular interactions involved in the development and organization of each secondary lymphoid organ are slightly different and probably reflect the cell types available at that time and location. Here we review the mechanisms involved in the development, organization and function of local lymphoid tissues in the respiratory tract, including Nasal Associated Lymphoid Tissue (NALT) and inducible Bronchus Associated Lymphoid Tissue (iBALT).

New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance.

PubMed

Daiber, A; Wenzel, P; Oelze, M; Münzel, T

2008-01-01

Organic nitrates still represent a group of very effective anti-ischemic drugs used for the treatment of patients with stable angina, acute myocardial infarction and chronic congestive heart failure. Long-term therapy with organic nitrates, however, results in a rapid development of nitrate tolerance blunting their hemodynamic and antiischemic efficacy. Recent studies revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase, the mitochondrial aldehyde dehydrogenase (ALDH-2), play an important role for the development of nitrate and crosstolerance. The present review focuses firstly on the role of ALDH-2 for organic nitrate bioactivation and secondly on the role of oxidative stress in the development of tolerance and cross-tolerance (endothelial dysfunction) in response to various organic nitrates. Finally, we would like to draw the reader's attention to the protective properties of the organic nitrate pentaerithrityl tetranitrate (PETN), which, in contrast to all other organic nitrates, is able to upregulate enzymes with a strong antioxidative capacity thereby preventing tolerance and the development of endothelial dysfunction.

Do soils loose phosphorus with dissolved organic matter?

NASA Astrophysics Data System (ADS)

Kaiser, K.; Brödlin, D.; Hagedorn, F.

2014-12-01

During ecosystem development and soil formation, primary mineral sources of phosphorus are becoming increasingly depleted. Inorganic phosphorus forms tend to be bound strongly to or within secondary minerals, thus, are hardly available to plants and are not leached from soil. What about organic forms of phosphorus? Since rarely studied, little is known on the composition, mobility, and bioavailability of dissolved organic phosphorus. There is some evidence that plant-derived compounds, such as phytate, bind strongly to minerals as well, while microbial compounds, such as nucleotides and nucleic acids, may represent more mobile fractions of soil phosphorus. In some weakly developed, shallow soils, leaching losses of phosphorus seem to be governed by mobile organic forms. Consequently, much of the phosphorus losses observed during initial stages of ecosystem development may be due to the leaching of dissolved organic matter. However, the potentially mobile microbial compounds are enzymatically hydrolysable. Forest ecosystems on developed soils already depleted in easily available inorganic phosphorus are characterized by rapid recycling of organic phosphors. That can reduce the production of soluble forms of organic phosphorus as well as increase the enzymatic hydrolysis and subsequent plant uptake of phosphorus bound within dissolved organic matter. This work aims at giving an outlook to the potential role of dissolved organic matter in the cycling of phosphorus within developing forest ecosystems, based on literature evidence and first results of ongoing research.

How Multi-Organ Microdevices Can Help Foster Drug Development

PubMed Central

Esch, Mandy B.; Smith, Alec; Prot, Jean-Matthieu; Sancho, Carlotta Oleaga; Hickman, James; Shuler, Michael L.

2014-01-01

Multi-organ microdevices can mimic tissue-tissue interactions that occur as a result of metabolite travel from one tissue to other tissues in vitro. These systems are capable of simulating human metabolism, including the conversion of a pro-drug to its effective metabolite as well as its subsequent therapeutic actions and toxic side effects. Since tissue-tissue interactions in the human body can play a significant role in determining the success of new pharmaceuticals, the development and use of multi-organ microdevices presents an opportunity to improve the drug development process. The goals are to predict potential toxic side effects with higher accuracy before a drug enters the expensive phase of clinical trials as well as to estimate efficacy and dose response. Multi-organ microdevices also have the potential to aid in the development of new therapeutic strategies by providing a platform for testing in the context of human metabolism (as opposed to animal models). Further, when operated with human biopsy samples, the devices could be a gateway for the development of individualized medicine. Here we review studies in which multi-organ microdevices have been developed and used in a ways that demonstrate how the devices’ capabilities can present unique opportunities for the study of drug action. We also discuss the challenges that are inherent in the development of multi-organ microdevices. Among these are how to design the devices, and how to create devices that mimic the human metabolism with high authenticity. Since single organ devices are testing platforms for tissues that can later be combined with other tissues within multi-organ devices, we will also mention single organ devices where appropriate in the discussion. PMID:24412641

25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

Code of Federal Regulations, 2012 CFR

2012-04-01

... organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108 Indians BUREAU... Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be: (1) Developed...

Applying Western Organization Development in China: Lessons from a Case of Success

ERIC Educational Resources Information Center

Wang, Jia

2010-01-01

Purpose: The purpose of this paper is to explore a successful case of a Chinese state-owned enterprise (SOE) as it applied western organization development (OD) approaches. Specifically, this study seeks to answer two questions: How has western organization development and change (OD/C) been applied in one Chinese SOE? and What lessons can be…

On the road to bioartificial organs.

PubMed

Ren, X; Ott, H C

2014-10-01

Biological organs are highly orchestrated systems with well-coordinated positioning, grouping, and interaction of different cell types within their specialized extracellular environment. Bioartificial organs are intended to be functional replacements of native organs generated through bioengineering techniques and hold the potential to alleviate donor organ shortage for transplantation. The development, production, and evaluation of such bioartificial organs require synergistic efforts of biology, material science, engineering, and medicine. In this review, we highlight the emerging platforms enabling structured assembly of multiple cell types into functional grafts and discuss recent advances and challenges in the development of bioartificial organs, including cell sources, in vitro organ culture, in vivo evaluation, and clinical considerations.

The standards process: X3 information processing systems

NASA Technical Reports Server (NTRS)

Emard, Jean-Paul

1993-01-01

The topics are presented in viewgraph form and include the following: International Organization for Standards (ISO); International Electrotechnical Committee (IEC); ISO/IEC Joint Technical Committee 1 (JTC-1); U.S. interface to JTC-1; ANSI; national organizations; U.S. standards development processes; national and international standards developing organizations; regional organizations; and X3 information processing systems.

Organized Activity Participation, Positive Youth Development, and the Over-Scheduling Hypothesis. Social Policy Report. Volume 20, Number 4

ERIC Educational Resources Information Center

Mahoney, Joseph L.; Harris, Angel L.; Eccles, Jacquelynne S.

2006-01-01

There is increasing awareness that how young people spend their time outside of school has consequences for their development. As part of this awareness, interest in organized activities--extracurricular activities, after-school programs, and youth organizations--has grown markedly. On balance, the bulk of research on organized activities has…

Developing Sediment Remediation Goals at Superfund Sites Based on Pore Water for the Protection of Benthic Organisms from Direct Toxicity to Non-ionic Organic Contaminants

EPA Science Inventory

This document contains a methodology for developing interstitial water remediation goals (IWRGs) for nonionic organic pollutants (toxicants) in sediments for the protection of benthic organisms. The document provides the basis for using the final chronic values (FCVs) from EPA’s...

Epigenetic Modifications Unlock the Milk Protein Gene Loci during Mouse Mammary Gland Development and Differentiation

PubMed Central

Rijnkels, Monique; Freeman-Zadrowski, Courtneay; Hernandez, Joseph; Potluri, Vani; Wang, Liguo; Li, Wei; Lemay, Danielle G.

2013-01-01

Background Unlike other tissues, development and differentiation of the mammary gland occur mostly after birth. The roles of systemic hormones and local growth factors important for this development and functional differentiation are well-studied. In other tissues, it has been shown that chromatin organization plays a key role in transcriptional regulation and underlies epigenetic regulation during development and differentiation. However, the role of chromatin organization in mammary gland development and differentiation is less well-defined. Here, we have studied the changes in chromatin organization at the milk protein gene loci (casein, whey acidic protein, and others) in the mouse mammary gland before and after functional differentiation. Methodology/Principal Findings Distal regulatory elements within the casein gene cluster and whey acidic protein gene region have an open chromatin organization after pubertal development, while proximal promoters only gain open-chromatin marks during pregnancy in conjunction with the major induction of their expression. In contrast, other milk protein genes, such as alpha-lactalbumin, already have an open chromatin organization in the mature virgin gland. Changes in chromatin organization in the casein gene cluster region that are present after puberty persisted after lactation has ceased, while the changes which occurred during pregnancy at the gene promoters were not maintained. In general, mammary gland expressed genes and their regulatory elements exhibit developmental stage- and tissue-specific chromatin organization. Conclusions/Significance A progressive gain of epigenetic marks indicative of open/active chromatin on genes marking functional differentiation accompanies the development of the mammary gland. These results support a model in which a chromatin organization is established during pubertal development that is then poised to respond to the systemic hormonal signals of pregnancy and lactation to achieve the full functional capacity of the mammary gland. PMID:23301053

Seeking Innovation: Librarians Help Push Organizations Ahead.

ERIC Educational Resources Information Center

Hudner, Ed

2002-01-01

Defines and discusses innovation in organizations and considers roles that information professionals can play in encouraging and supporting innovation in their organizations. Highlights include understanding future possibilities; contributing to strategy development; distilling information to create added value; developing partnerships; organizing…

Forest products research and development organizations in a worldwide setting: A review of structure, governance, and measures of performance of organizations outside the United States

Treesearch

Paul V. Ellefson; Michael A. Kilgore; Kenneth E. Skog; Christopher D. Risbrudt

2007-01-01

Located in 23 countries, 40 forest-products research and development organizations outside the United States were reviewed in 2004 and 2005. The intent was to obtain a better understanding of how such organizations are structured and administered and their performance judged. Investing over $600 million annually, the 40 organizations employed 7,000 to 7,500 scientists...

Quantification of Pelvic Organ Prolapse in Mice: Vaginal Protease Activity Precedes Increased MOPQ Scores in Fibulin 5 Knockout Mice1

PubMed Central

Wieslander, Cecilia K.; Rahn, David D.; McIntire, Donald D.; Acevedo, Jesús F.; Drewes, Peter G.; Yanagisawa, Hiromi; Word, R. Ann

2008-01-01

Two mouse models of pelvic organ prolapse have been generated recently, both of which have null mutations in genes involved in elastic fiber synthesis and assembly (fibulin 5 and lysyl oxidase-like 1). Interestingly, although these mice exhibit elastinopathies early in life, pelvic organ prolapse does not develop until later in life. In this investigation we developed and validated a tool to quantify the severity of pelvic organ prolapse in mice, and we used this tool prospectively to study the role of fibulin 5, aging, and vaginal proteases in the development of pelvic organ prolapse. The results indicate that >90% of Fbln5−/− mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and that increased vaginal protease activity precedes the development of prolapse. PMID:18987327

Integrating centralized and decentralized organization structures: an education and development model.

PubMed

Sheriff, R; Banks, A

2001-01-01

Organization change efforts have led to critically examining the structure of education and development departments within hospitals. This qualitative study evaluated an education and development model in an academic health sciences center. The model combines centralization and decentralization. The study results can be used by staff development educators and administrators when organization structure is questioned. This particular model maximizes the benefits and minimizes the limitations of centralized and decentralized structures.

Modeling the influence of organic acids on soil weathering

NASA Astrophysics Data System (ADS)

Lawrence, Corey; Harden, Jennifer; Maher, Kate

2014-08-01

Biological inputs and organic matter cycling have long been regarded as important factors in the physical and chemical development of soils. In particular, the extent to which low molecular weight organic acids, such as oxalate, influence geochemical reactions has been widely studied. Although the effects of organic acids are diverse, there is strong evidence that organic acids accelerate the dissolution of some minerals. However, the influence of organic acids at the field-scale and over the timescales of soil development has not been evaluated in detail. In this study, a reactive-transport model of soil chemical weathering and pedogenic development was used to quantify the extent to which organic acid cycling controls mineral dissolution rates and long-term patterns of chemical weathering. Specifically, oxalic acid was added to simulations of soil development to investigate a well-studied chronosequence of soils near Santa Cruz, CA. The model formulation includes organic acid input, transport, decomposition, organic-metal aqueous complexation and mineral surface complexation in various combinations. Results suggest that although organic acid reactions accelerate mineral dissolution rates near the soil surface, the net response is an overall decrease in chemical weathering. Model results demonstrate the importance of organic acid input concentrations, fluid flow, decomposition and secondary mineral precipitation rates on the evolution of mineral weathering fronts. In particular, model soil profile evolution is sensitive to kaolinite precipitation and oxalate decomposition rates. The soil profile-scale modeling presented here provides insights into the influence of organic carbon cycling on soil weathering and pedogenesis and supports the need for further field-scale measurements of the flux and speciation of reactive organic compounds.

Modeling the influence of organic acids on soil weathering

USGS Publications Warehouse

Lawrence, Corey R.; Harden, Jennifer W.; Maher, Kate

2014-01-01

Biological inputs and organic matter cycling have long been regarded as important factors in the physical and chemical development of soils. In particular, the extent to which low molecular weight organic acids, such as oxalate, influence geochemical reactions has been widely studied. Although the effects of organic acids are diverse, there is strong evidence that organic acids accelerate the dissolution of some minerals. However, the influence of organic acids at the field-scale and over the timescales of soil development has not been evaluated in detail. In this study, a reactive-transport model of soil chemical weathering and pedogenic development was used to quantify the extent to which organic acid cycling controls mineral dissolution rates and long-term patterns of chemical weathering. Specifically, oxalic acid was added to simulations of soil development to investigate a well-studied chronosequence of soils near Santa Cruz, CA. The model formulation includes organic acid input, transport, decomposition, organic-metal aqueous complexation and mineral surface complexation in various combinations. Results suggest that although organic acid reactions accelerate mineral dissolution rates near the soil surface, the net response is an overall decrease in chemical weathering. Model results demonstrate the importance of organic acid input concentrations, fluid flow, decomposition and secondary mineral precipitation rates on the evolution of mineral weathering fronts. In particular, model soil profile evolution is sensitive to kaolinite precipitation and oxalate decomposition rates. The soil profile-scale modeling presented here provides insights into the influence of organic carbon cycling on soil weathering and pedogenesis and supports the need for further field-scale measurements of the flux and speciation of reactive organic compounds.

Managing and Developing People in the Virtual Organization. Professional Practices in Adult Education and Human Resource Development Series.

ERIC Educational Resources Information Center

Colky, Deborah Lavin; Colky, Michael T.; Young, William H., III

Designed for managers and workers in virtual organizations as well as adult and continuing educators in higher education, associations, and private sector, this book outlines a customer-driven performance management system and explains its use as a development tool. The characteristics of virtual organizations are described, and the rationale for…

Helping organizations help others: organization development as a facilitator of social change.

PubMed

Boyd, Neil M

2011-01-01

This article explores organization development (OD) interventions and their likelihood of increasing social change outcomes in public agencies. The central argument of this work is that public and nonprofit organizations can deliver better social outcomes by systematically engaging in OD interventions. An in-depth survey was conducted in 3 agencies of the Commonwealth of Pennsylvania at the end of the gubernatorial administration of Tom Ridge (1995-2002). During his administration, Governor Ridge led the agencies of Pennsylvania government through a large-scale change effort to improve the efficiency and effectiveness of service delivery to the citizens of the Commonwealth of Pennsylvania. The change effort was a remarkable event for the Commonwealth because no other governor in the history of the state had attempted to conceptualize and deliver a comprehensive large-scale change management initiative. The successes and setbacks served as a fertile context to shed light on the following research question: Do OD interventions increase the likelihood that public organizations will deliver better social outcomes? This question is important in that public organizations may need to engage in organization development activities to improve their internal operations, which in turn may help them provide exemplary social outcomes to those whom they serve. In short, organization development interventions might allow public organizations to help themselves to help others.

Administrator self-ratings of organization capacity and performance of healthy community development projects in Taiwan.

PubMed

Chen, Ching-Min; Hong, Mei-Chu; Hsu, Yu-Hsien

2007-01-01

To examine the relationship between the capacities of various community organizations and their performance scores for healthy community development. This cross-sectional study was conducted by examining all community organizations involved in the Taiwan national healthy community development project. Of 213 administrators contacted, 195 (a return rate of 91.6%) completed a self-administered questionnaire between October and November 2003. The research instrument was self-developed and based on the Donabedian model. It examined the capacity of the community organizations and their performance in developing a healthy community. The average overall healthy community development performance score was 5.0 on a 7-point semantic differential scale, with the structure variable rated as the lowest among the 3 subscales. Community organization capacities in the areas of funding, resources committed, citizen participation, and certain aspects of organizational leadership were found to be significantly related to healthy community development performance. Each of the regression models showed a different set of capacities for the community organization domains and explained between 25% and 33% of the variance in performance. The study validates the theoretical relationships among the concepts identified in the Donabedian model. Nursing interventions tailored to enhance resident citizen participation in order to promote community coalitions are strongly supported.

Non-Destructive High-Resolution Organic Matter Record on Lake Sediment using Steady-State Solid Phase Fluorescence: Organic Matter Quality and Quantity Assessment.

NASA Astrophysics Data System (ADS)

Quiers, M.; Perrette, Y.; Etienne, D.; Develle, A. L.; Jacq, K.

2017-12-01

The use of organic proxies increases in paleoenvironmental reconstructions from natural archives. Major advances have been achieved by the development of new highly informative molecular proxies usually linked to specific compounds. While studies focused on targeted compounds, offering a high information degree, advances on bulk organic matter are limited. However, this bulk is the main contributor to carbon cycle and has been shown to be a driver of many mineral or organic compounds transfer and record. Development of target proxies need complementary information on bulk organic matter to understand biases link to controlling factors or analytical methods, and provide a robust interpretation. Fluorescence methods have often been employed to characterize and quantify organic matter. However, these technics are mainly developed for liquid samples, inducing material and resolution loss when working on natural archives (either stalagmite or sediments). High-resolution solid phase fluorescence (SPF) was developed on speleothems. This method allows now to analyse organic matter quality and quantity if procedure to constrain the optical density are adopted. In fact, a calibration method using liquid phase fluorescence (LPF) was developed for speleothem, allowing to quantify organic carbon at high-resolution. We report here an application of such a procedure SPF/LPF measurements on lake sediments. In order to avoid sediment matrix effects on the fluorescence signal, a calibration using LPF measurements was realised. First results using this method provided organic matter quality record of different organic matter compounds (humic-like, protein-like and chlorophylle-like compounds) at high resolution for the sediment core. High resolution organic matter fluxes are obtained in a second time, applying pragmatic chemometrics model (non linear models, partial least square models) on high resolution fluorescence data. SPF method can be considered as a promising tool for high resolution record on organic matter quality and quantity. Potential application of this method will be evocated (lake ecosystem dynamic, changes in trophic levels)

Study on the measures to promote the use of photovoltaic power generating system overseas

NASA Astrophysics Data System (ADS)

1989-03-01

In order to understand the state of the utilizing photovoltaic power generating system, the present situation to promote its development, the actual status of the assistance for developing countries by each country or by each international organization, research was done for USA, principal western countries, UN and EC. First, development conditions of the solar cell utilizing technique were classified by each country at the standpoint of developing and promoting systems. Second, the projects and policies in each country or international organization were arranged to promote research, development and introduction. Next, the present situation of the photovoltaic power generation projects by civilian parties and the problems to assist the projects by each country were arranged. While, the present sutuation of the photovoltaic power generation projects assisted by the governments and international organizations were classified by each country and each international organizations. Finally, in view of importance in the photovoltaic power generation project, it was concluded that not only developed country governments and international organizations but also private enterprises in developed countries were required to expand the understanding about the photovoltaic power generation system.

How does Learning Impact Development in Infancy? The Case of Perceptual Organization

PubMed Central

Bhatt, Ramesh S.; Quinn, Paul C.

2011-01-01

Pattern perception and organization are critical functions of the visual cognition system. Many organizational processes are available early in life, such that infants as young 3 months of age are able to readily utilize a variety of cues to organize visual patterns. However, other processes are not readily evident in young infants, and their development involves perceptual learning. We describe a theoretical framework that addresses perceptual learning in infancy and the manner in which it affects visual organization and development. It identifies five kinds of experiences that induce learning, and suggests that they work via attentional and unitization mechanisms to modify visual organization. In addition, the framework proposes that this kind of learning is abstract, domain general, functional at different ages in a qualitatively similar manner, and has a long-term impact on development through a memory reactivation process. Although most models of development assume that experience is fundamental to development, very little is actually known about the process by which experience affects development. The proposed framework is an attempt to account for this process in the domain of perception. PMID:21572570

Mathematical Problem Solving Project Technical Report III: Module Development and Formative Evaluation. Appendix B - "Organizing Lists" Quizzes and Data.

ERIC Educational Resources Information Center

Indiana Univ., Bloomington. Mathematics Education Development Center.

This appendix to the Mathematical Problem Solving Project "Module Development and Formative Evaluation" contains trials 1 and 2 of the Organizing Lists quiz. Editorial feedback from teachers on the Organizing Lists booklet is given for trials 1 and 2. Editorial feedback from teachers on the Organizing Lists problem deck is given for…

Organization Development and U.S. Institutions of Higher Education: A Thematic Meta-Synthesis of Approaches and Practice

ERIC Educational Resources Information Center

Overstreet, Kirk E., Jr.

2017-01-01

Organization Development (OD) has been used in a variety of ways to improve organizations both large and small. Interestingly, the institutions that teach and conduct research on organizations have been slow to adopt or utilize OD approaches and practices in their own institutions. This dissertation will use a thematic meta-synthesis approach to…

Frogs as integrative models for understanding digestive organ development and evolution

PubMed Central

Womble, Mandy; Pickett, Melissa; Nascone-Yoder, Nanette

2016-01-01

The digestive system comprises numerous cells, tissues and organs that are essential for the proper assimilation of nutrients and energy. Many aspects of digestive organ function are highly conserved among vertebrates, yet the final anatomical configuration of the gut varies widely between species, especially those with different diets. Improved understanding of the complex molecular and cellular events that orchestrate digestive organ development is pertinent to many areas of biology and medicine, including the regeneration or replacement of diseased organs, the etiology of digestive organ birth defects, and the evolution of specialized features of digestive anatomy. In this review, we highlight specific examples of how investigations using Xenopus laevis frog embryos have revealed insight into the molecular and cellular dynamics of digestive organ patterning and morphogenesis that would have been difficult to obtain in other animal models. Additionally, we discuss recent studies of gut development in non-model frog species with unique feeding strategies, such as Lepidobatrachus laev is and Eleutherodactylouscoqui, which are beginning to provide glimpses of the evolutionary mechanisms that may generate morphological variation in the digestive tract. The unparalleled experimental versatility of frog embryos make them excellent, integrative models for studying digestive organ development across multiple disciplines. PMID:26851628

New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality.

PubMed

Lin, John C; Spinella, Philip C; Fitzgerald, Julie C; Tucci, Marisa; Bush, Jenny L; Nadkarni, Vinay M; Thomas, Neal J; Weiss, Scott L

2017-01-01

To describe the epidemiology, morbidity, and mortality of new or progressive multiple organ dysfunction syndrome in children with severe sepsis. Secondary analysis of a prospective, cross-sectional, point prevalence study. International, multicenter PICUs. Pediatric patients with severe sepsis identified on five separate days over a 1-year period. None. Of 567 patients from 128 PICUs in 26 countries enrolled, 384 (68%) developed multiple organ dysfunction syndrome within 7 days of severe sepsis recognition. Three hundred twenty-seven had multiple organ dysfunction syndrome on the day of sepsis recognition. Ninety-one of these patients developed progressive multiple organ dysfunction syndrome, whereas an additional 57 patients subsequently developed new multiple organ dysfunction syndrome, yielding a total proportion with severe sepsis-associated new or progressive multiple organ dysfunction syndrome of 26%. Hospital mortality in patients with progressive multiple organ dysfunction syndrome was 51% compared with patients with new multiple organ dysfunction syndrome (28%) and those with single-organ dysfunction without multiple organ dysfunction syndrome (10%) (p < 0.001). Survivors of new or progressive multiple organ dysfunction syndrome also had a higher frequency of moderate to severe disability defined as a Pediatric Overall Performance Category score of greater than or equal to 3 and an increase of greater than or equal to 1 from baseline: 22% versus 29% versus 11% for progressive, new, and no multiple organ dysfunction syndrome, respectively (p < 0.001). Development of new or progressive multiple organ dysfunction syndrome is common (26%) in severe sepsis and is associated with a higher risk of morbidity and mortality than severe sepsis without new or progressive multiple organ dysfunction syndrome. Our data support the use of new or progressive multiple organ dysfunction syndrome as an important outcome in trials of pediatric severe sepsis although efforts are needed to validate whether reducing new or progressive multiple organ dysfunction syndrome leads to improvements in more definitive morbidity and mortality endpoints.

U.S. private voluntary organizations in development: an assessment.

PubMed

Schwartz, E

1980-10-01

The strengths and weaknesses of U.S. private voluntary organizations were compared to other types of organizations. Private voluntary organizations (PVOs), in general, are organizations that are private, non-profit, and tax-exempt. Voluntary is a reference more to the nature of the contributions individuals may make to these organizations than to their volunteer-sending programs. Cooperative organizations are included within the definition, but universities, colleges, and various research or scientific institutions are not. The primary issue in this evaluation was to determine the effectiveness of the PVOs in carrying out development assistance efforts. Current consensus would rate the PVOs as excellent practitioners of the basic human needs development strategy at the grassroots level. They have been leaders and innovators of this approach, and it is in this area that they have a comparative advantage. The work of PVOs has also been expanding in areas identified as most useful by development specialists. The 7 criteria that may be used in assessing the effectiveness of PVOs in meeting development assistance goals are reviewed: 1) fostering self-help initiative among the poorest of the poor; 2) mobilizing U.S. private financial and human resources; 3) stimulating innovative projects which can be replicated elsewhere; 4) strengthening people-to-people contact; 5) encouraging the establishment of indigenous participatory institutions; 6) creating conditions for self-sustaining development efforts; and 7) increasing the capacity of less developed countries to absorb outside capital by increasing the level of local skills and resources.

Self-organizing periodicity in development: organ positioning in plants.

PubMed

Bhatia, Neha; Heisler, Marcus G

2018-02-08

Periodic patterns during development often occur spontaneously through a process of self-organization. While reaction-diffusion mechanisms are often invoked, other types of mechanisms that involve cell-cell interactions and mechanical buckling have also been identified. Phyllotaxis, or the positioning of plant organs, has emerged as an excellent model system to study the self-organization of periodic patterns. At the macro scale, the regular spacing of organs on the growing plant shoot gives rise to the typical spiral and whorled arrangements of plant organs found in nature. In turn, this spacing relies on complex patterns of cell polarity that involve feedback between a signaling molecule - the plant hormone auxin - and its polar, cell-to-cell transport. Here, we review recent progress in understanding phyllotaxis and plant cell polarity and highlight the development of new tools that can help address the remaining gaps in our understanding. © 2018. Published by The Company of Biologists Ltd.

Organizing a Learning Center.

ERIC Educational Resources Information Center

Davis, Harold S.

The organization and development of instructional materials centers (IMC's) as a part of a program of educational improvement is discussed. Analysis is made of the advantages, disadvantages, and organization of centralized IMC's, decentralized IMC's, and coordinated IMC's, with recommendations being made for their development. The operation of…

Developing Culturally Competent Organizations.

ERIC Educational Resources Information Center

Focal Point, 1994

1994-01-01

This special issue examines multicultural aspects of services provided by agencies concerned with children's mental health. The lead article is titled "Developing Culturally Competent Organizations" by James L. Mason. This article uses the cultural competence model to discuss an organization's self-evaluation and its planning in the…

Organization Development. Symposium.

ERIC Educational Resources Information Center

2002

This document contains four papers on organization development and human resources. "Identification of Key Predictors of Rapid Change Adaptation in a Service Organization" (Constantine Kontoghiorghes, Carol Hansen) reports on the results of an exploratory study, which suggests that rapid change adaptation will be more likely to occur in…

Student Organizations as Avenues for Leader Learning and Development.

PubMed

Sessa, Valerie I; Alonso, Nicole; Farago, Pamela; Schettino, Gaynell; Tacchi, Kelcie; Bragger, Jennifer D

2017-09-01

This chapter describes theory and research demonstrating that the experiences students have within student organizations, and the people with whom they interact within those organizations, are powerful triggers for leader learning and development. © 2017 Wiley Periodicals, Inc., A Wiley Company.

Stem Cell Fate Determination during Development and Regeneration of Ectodermal Organs

PubMed Central

Jiménez-Rojo, Lucía; Granchi, Zoraide; Graf, Daniel; Mitsiadis, Thimios A.

2012-01-01

The development of ectoderm-derived appendages results in a large variety of highly specialized organs such as hair follicles, mammary glands, salivary glands, and teeth. Despite varying in number, shape, and function, all these ectodermal organs develop through continuous and reciprocal epithelial–mesenchymal interactions, sharing common morphological and molecular features especially during their embryonic development. Diseases such as ectodermal dysplasias can affect simultaneously these organs, suggesting that they may arise from common multipotent precursors residing in the embryonic ectoderm. During embryogenesis, these putative ectodermal stem cells may adopt different fates and consequently be able to generate a variety of tissue-specific stem cells, which are the sources for the various cell lineages that form the diverse organs. The specification of those common epithelial precursors, as well as their further lineage commitment to tissue-specific stem cells, might be controlled by specific signals. It has been well documented that Notch, Wnt, bone morphogenetic protein, and fibroblast growth factor signaling pathways regulate cell fate decisions during the various stages of ectodermal organ development. However, the in vivo spatial and temporal dynamics of these signaling pathways are not yet well understood. Improving the current knowledge on the mechanisms involved in stem cell fate determination during organogenesis and homeostasis of ectodermal organs is crucial to develop effective stem cell-based therapies in order to regenerate or replace pathological and damaged tissues. PMID:22539926

Stem Cell Fate Determination during Development and Regeneration of Ectodermal Organs.

PubMed

Jiménez-Rojo, Lucía; Granchi, Zoraide; Graf, Daniel; Mitsiadis, Thimios A

2012-01-01

The development of ectoderm-derived appendages results in a large variety of highly specialized organs such as hair follicles, mammary glands, salivary glands, and teeth. Despite varying in number, shape, and function, all these ectodermal organs develop through continuous and reciprocal epithelial-mesenchymal interactions, sharing common morphological and molecular features especially during their embryonic development. Diseases such as ectodermal dysplasias can affect simultaneously these organs, suggesting that they may arise from common multipotent precursors residing in the embryonic ectoderm. During embryogenesis, these putative ectodermal stem cells may adopt different fates and consequently be able to generate a variety of tissue-specific stem cells, which are the sources for the various cell lineages that form the diverse organs. The specification of those common epithelial precursors, as well as their further lineage commitment to tissue-specific stem cells, might be controlled by specific signals. It has been well documented that Notch, Wnt, bone morphogenetic protein, and fibroblast growth factor signaling pathways regulate cell fate decisions during the various stages of ectodermal organ development. However, the in vivo spatial and temporal dynamics of these signaling pathways are not yet well understood. Improving the current knowledge on the mechanisms involved in stem cell fate determination during organogenesis and homeostasis of ectodermal organs is crucial to develop effective stem cell-based therapies in order to regenerate or replace pathological and damaged tissues.

Lunar carbon chemistry - Relations to and implications for terrestrial organic geochemistry.

NASA Technical Reports Server (NTRS)

Eglinton, G.; Maxwell, J. R.; Pillinger, C. T.

1972-01-01

Survey of the various ways in which studies of lunar carbon chemistry have beneficially affected terrestrial organic geochemistry. A lunar organic gas-analysis operating system is cited as the most important instrumental development in relation to terrestrial organic geochemistry. Improved methods of analysis and handling of organic samples are cited as another benefit derived from studies of lunar carbon chemistry. The problem of controlling contamination and minimizing organic vapors is considered, as well as the possibility of analyzing terrestrial samples by the techniques developed for lunar samples. A need for new methods of analyzing carbonaceous material which is insoluble in organic solvents is indicated.

[The development of World Federation of Acupuncture-Moxibustion Societies].

PubMed

Wang, Hong-cai; Deng, Liang-yue; Liu, Bao-yan

2014-10-01

From cooperation between World Federation of Acupuncture-Moxibustion Societies (WFAS) and World Health Organization, works of academics and standardization, acupuncture-moxibustion education, technique service, organization development, etc., the 27-year development of WFAS since 1987 was summarized and reviewed in details. The growth of WFAS witnesses and promotes the development of acupuncture and moxibustion in the world, so by learning the experience and lessons, WFAS could have a wider path, becoming a core organization for communicating and promoting the development of acupuncture, even the traditional medicine in the world.

Government Open Systems Interconnection Profile (GOSIP) Transition Strategy

DTIC Science & Technology

1993-09-01

it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed their...version 1 and 2. Additionally, it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed ...ORGANIZATION OF STUDY 1. The Standards Process Chapter II describes the process whereby standards are developed and adopted by the ISO and how the

Developing Molecular Methods to Identify and Quantify Ballast Water Organisms: A Test Case with Cnidarians

DTIC Science & Technology

2004-04-15

Developing Molecular Methods to Identify and Quantify Ballast Water Organisms: A Test Case with Cnidarians SERDP Project # CP-1251...2004 4. TITLE AND SUBTITLE Developing Molecular Methods to Identify and Quantify Ballast Water Organisms: A Test Case with Cnidarians 5a. CONTRACT... cnidarians ? 9 Indicators of ballast water exchange 9 Materials and Methods 11 Phase I. Specimens 11 DNA

The impact of collaborations between universities and private organizations on cluster development and competitiveness in Romania

NASA Astrophysics Data System (ADS)

Stoicovici, D.; Bănică, M.; Ungureanu, M.; Stoicovici, M.

2017-05-01

While the European Union has put a lot of emphasis on cluster development due to their inherent advantages such as lower transaction costs, technological transfer and regional development, little is known about how clusters emerge and what can facilitate their competitiveness. This paper aims to study the impact of public-private cooperation between universities and organizations on cluster development and competitiveness. A literature review is employed to develop the model while 4 qualitative case studies provide the initial test of its validity. The analysis suggests that cooperating with research institutions impacts cluster development first through education of industrial staff, but also by developing innovation processes through the facilitation of the appearance of innovative ideas and also of knowledge sharing among organizations. The research has several implications both for organizations and for government officials. First of all, R&D and top management should actively seek to cooperate with research institutions both for training of their staff but also in seeking new ideas and as a way of collaborating with other organizations within the field without fear of losing competitive advantage. Second, government officials should try to create more incentives both for organizations (through for example tax returns) and for universities (extra funding or salary incentives) that can increase collaboration between these actors. This paper is the first one to asses empirically how cooperation with research institutions affect cluster competitiveness and development, especially within the developing region of Eastern Europe, Romania.

Computer-aided mechanogenesis of skeletal muscle organs from single cells in vitro

NASA Technical Reports Server (NTRS)

Vanderburgh, Herman H.; Swasdison, Somporn; Karlisch, Patricia

1991-01-01

Complex mechanical forces generated in the growing embryo play an important role in organogenesis. Computerized application of similar forces to differentiating skeletal muscle myoblasts in vitro generate three dimensional artificial muscle organs. These organs contain parallel networks of long unbranched myofibers organized into fascicle-like structures. Tendon development is initiated and the muscles are capable of performing directed, functional work. Kinetically engineered organs provide a new method for studying the growth and development of normal and diseased skeletal muscle.

Computer aided mechanogenesis of skeletal muscle organs from single cells in vitro

NASA Technical Reports Server (NTRS)

Vandenburgh, Herman H.; Swasdison, Somporn; Karlisch, Patricia

1990-01-01

Complex mechanical forces generated in the growing embryo play an important role in organogenesis. Computerized application of similar forces to differentiating skeletal muscle myoblasts in vitro generate three dimensional artificial muscle organs. These organs contain parallel networks of long unbranched myofibers organized into fascicle-like structures. Tendon development is initiated and the muscles are capable of performing directed, functional work. Kinetically engineered organs provide a new method for studying the growth and development of normal and diseased skeletal muscle.

Wade Braunecker | NREL

Science.gov Websites

; copolymers for a number of systematic studies in the field of organic photovoltaics (OPV). He became a Staff nitroxide radical groups for application as organic radical cathode materials, the development of materials been developing covalent organic frameworks for gas storage and separation applications. Research

Why Join an Art Education Organization?: Part 1

ERIC Educational Resources Information Center

Passmore, Kaye

2006-01-01

In this article, the author discusses several good reasons for belonging to local, state, and national professional art education organizations. When one actively participates, he/she develops networks with other art educators. Professional organizations provide opportunities for professional development, service, and leadership. One's teaching…

Do organizations spend wisely on employees? Effects of training and development investments on learning and innovation in organizations

PubMed Central

Sung, Sun Young; Choi, Jin Nam

2014-01-01

The present study examines the effects of training and development on organizational innovation. We specifically suggest that the training and development investments of an organization affect its innovative performance by promoting various learning practices. We empirically tested our hypothesis by using time-lagged, multi-source data collected from 260 Korean companies that represent diverse industries. Our analysis showed that corporate expenditure for internal training predicts interpersonal and organizational learning practices, which, in turn, increase innovative performance. The data also revealed that the positive relationship between interpersonal and organizational learning practices and innovative performance is stronger within organizations that have stronger innovative climates. By contrast, investment in employee development through financial support for education outside an organization poses a significant negative effect on its innovative performance and no significant effect on learning practices. The present study provides a plausible explanation for a mechanism through which the investment of an organization in employees enhances its innovative performance. Copyright © 2013 The Authors. PMID:25598576

Do organizations spend wisely on employees? Effects of training and development investments on learning and innovation in organizations.

PubMed

Sung, Sun Young; Choi, Jin Nam

2014-04-01

The present study examines the effects of training and development on organizational innovation. We specifically suggest that the training and development investments of an organization affect its innovative performance by promoting various learning practices. We empirically tested our hypothesis by using time-lagged, multi-source data collected from 260 Korean companies that represent diverse industries. Our analysis showed that corporate expenditure for internal training predicts interpersonal and organizational learning practices, which, in turn, increase innovative performance. The data also revealed that the positive relationship between interpersonal and organizational learning practices and innovative performance is stronger within organizations that have stronger innovative climates. By contrast, investment in employee development through financial support for education outside an organization poses a significant negative effect on its innovative performance and no significant effect on learning practices. The present study provides a plausible explanation for a mechanism through which the investment of an organization in employees enhances its innovative performance. Copyright © 2013 The Authors.

24 CFR 92.301 - Project-specific assistance to community housing development organizations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Project-specific assistance to community housing development organizations. 92.301 Section 92.301 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM...

24 CFR 1003.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Special activities by Community-Based Development Organizations (CBDOs). 1003.204 Section 1003.204 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND...

24 CFR 570.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Special activities by Community-Based Development Organizations (CBDOs). 570.204 Section 570.204 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY...

24 CFR 570.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Special activities by Community-Based Development Organizations (CBDOs). 570.204 Section 570.204 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY...

24 CFR 570.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Special activities by Community-Based Development Organizations (CBDOs). 570.204 Section 570.204 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY...

24 CFR 1003.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Special activities by Community-Based Development Organizations (CBDOs). 1003.204 Section 1003.204 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND...

24 CFR 1003.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Special activities by Community-Based Development Organizations (CBDOs). 1003.204 Section 1003.204 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND...

24 CFR 570.204 - Special activities by Community-Based Development Organizations (CBDOs).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Special activities by Community-Based Development Organizations (CBDOs). 570.204 Section 570.204 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY...

24 CFR 92.208 - Eligible community housing development organization (CHDO) operating expense and capacity...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Eligible community housing development organization (CHDO) operating expense and capacity building costs. 92.208 Section 92.208 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME...

Development and validation of a portable gas phase standard generation and calibration system for volatile organic compounds

Treesearch

P. Veres; J. B. Gilman; J. M. Roberts; W. C. Kuster; C. Warneke; I. R. Burling; J. de Gouw

2010-01-01

We report on the development of an accurate, portable, dynamic calibration system for volatile organic compounds (VOCs). The Mobile Organic Carbon Calibration System (MOCCS) combines the production of gas-phase VOC standards using permeation or diffusion sources with quantitative total organic carbon (TOC) conversion on a palladium surface to CO2 in the presence of...

Centers of Stability Analysis - The Missing Framework in Joint Intelligence Preparation of the Operational Environment Doctrine

DTIC Science & Technology

2011-05-04

UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER...13 The general considerations for shaping operations are to organize and train forces, rehearse for future actions, maintaining operational area...threat. In reality, however, a prudent intelligence organization will begin to develop these products as indications develop that the shaping

History of deceased organ donation, transplantation, and organ procurement organizations.

PubMed

Howard, Richard J; Cornell, Danielle L; Cochran, Larry

2012-03-01

The historical development of deceased organ donation, transplantation, and organ procurement organizations is reviewed. The concept of transplantation, taking parts from one animal or person and putting them into another animal or person, is ancient. The development of organ transplantation brought on the need for a source of organs. Although many early kidney transplants used kidneys from living donors, these donors could not satisfy the ever-growing need for organs, and extrarenal organs were recovered only from deceased donors. This need for organs to satisfy the great demand led to specialized organizations to identify deceased donors, manage them until recovery occurred, and to notify transplant centers that organs were available for their patients. The functions of these organ procurement organizations expanded to include other required functions such as education, accounting, and compliance with state and federal requirements. Because of the shortage of organs relative to the demand, lack of a unified organ allocation system, the perception that organs are a national resource and should be governed by national regulations, and to improve results of organ procurement organizations and transplant centers, the federal government has regulated virtually all phases of organ procurement and transplantation.

Organization Development: A Case Study in Blockages.

ERIC Educational Resources Information Center

McIntyre, Martin

1981-01-01

Organization Development is a management science that defines and solves organizational problems. Procedures include: (1) diagnosis of problem; (2) gathering of data related to problem; (3) obtaining feedback; (4) developing various change strategies; (5) developing an action plan; and (6) implementing the plan. (CJ)

Workforce and Leader Development: Learning From the Baldrige Winners in Health Care.

PubMed

Arnold, Edwin W; Goodson, Jane R; Duarte, Neville T

2015-01-01

It is ironic that perhaps the only constant in health care organizations today is change. To compete successfully in health care and position an organization for high performance amid continuous change, it is very important for managers to have knowledge of the best learning and development practices of high-performing organizations in their industry. The rapid increases in the rate of technological change and geometric increases in knowledge make it virtually imperative that human resources are developed effectively. This article discusses the best learning and development practices among the Malcolm Baldrige National Quality Award winners in the health care industry since 2002 when the industry had its first award-winning organization.

Recent progress of high performance polymer OLED and OPV materials for organic printed electronics.

PubMed

Sekine, Chizu; Tsubata, Yoshiaki; Yamada, Takeshi; Kitano, Makoto; Doi, Shuji

2014-06-01

The development of organic printed electronics has been expanding to a variety of applications and is expected to bring innovations to our future life. Along with this trend, high performance organic materials with cost-efficient fabrication processes and specific features such as thin, light weight, bendable, and low power consumption are required. A variety of organic materials have been investigated in the development of this field. The basic guidelines for material design and the recent progress of polymer-based organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs) are reported.

Recent progress of high performance polymer OLED and OPV materials for organic printed electronics

PubMed Central

Sekine, Chizu; Tsubata, Yoshiaki; Yamada, Takeshi; Kitano, Makoto; Doi, Shuji

2014-01-01

The development of organic printed electronics has been expanding to a variety of applications and is expected to bring innovations to our future life. Along with this trend, high performance organic materials with cost-efficient fabrication processes and specific features such as thin, light weight, bendable, and low power consumption are required. A variety of organic materials have been investigated in the development of this field. The basic guidelines for material design and the recent progress of polymer-based organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs) are reported. PMID:27877671

Recent progress of high performance polymer OLED and OPV materials for organic printed electronics

NASA Astrophysics Data System (ADS)

Sekine, Chizu; Tsubata, Yoshiaki; Yamada, Takeshi; Kitano, Makoto; Doi, Shuji

2014-06-01

The development of organic printed electronics has been expanding to a variety of applications and is expected to bring innovations to our future life. Along with this trend, high performance organic materials with cost-efficient fabrication processes and specific features such as thin, light weight, bendable, and low power consumption are required. A variety of organic materials have been investigated in the development of this field. The basic guidelines for material design and the recent progress of polymer-based organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs) are reported.

Revisiting the Role of Organizational Effectiveness in Educational Evaluation.

ERIC Educational Resources Information Center

Lotto, Linda S.

Organizational effectiveness ought to play a role in educational evaluation, and the development of alternative perspectives for viewing organizations could be a starting point for revisiting organizational evaluation in education. Five possible perspectives and criteria for evaluating organizations have been developed. If an organization is…

Global Leadership Communication: A Strategic Proposal

ERIC Educational Resources Information Center

Lawrence, Tom

2015-01-01

Organizations face a myriad of challenges as the world interconnects through the process of globalization. In order to sustain viability and produce competitive advantage, organizations must develop a global communication strategy. Communication skills need to be developed at all levels of the organization, from a coherent mission statement to…

24 CFR 125.501 - Fair Housing Organizations Initiative.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Initiative. 125.501 Section 125.501 Housing and Urban Development Regulations Relating to Housing and Urban... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.501 Fair Housing Organizations Initiative. (a) The Fair Housing Organizations Initiative of the FHIP provides funding to develop or expand the ability of...

Management Planning and Control: Supporting Knowledge-Intensive Organizations

ERIC Educational Resources Information Center

Herremans, Irene M.; Isaac, Robert G.

2005-01-01

Purpose: The purpose of this paper is to develop propositions for empirical validation regarding appropriate management planning and control systems (MPACS) in knowledge-intensive organizations. Design/methodology/approach: The propositions were developed from interviews with members of a knowledge-intensive virtual organization that is known for…

Developing leadership talent in healthcare organizations.

PubMed

Wells, Wendy; Hejna, William

2009-01-01

Effective initiatives for developing and retaining leadership talent are built around five supporting elements: Identification of key leader competencies. Effective job design. A strong focus on leadership recruitment, development, and retention. Leadership training and development throughout all levels of the organization. Ongoing leadership assessment and performance management.

Benchmarking Professional Development Practices across Youth-Serving Organizations: Implications for Extension

ERIC Educational Resources Information Center

Garst, Barry A.; Baughman, Sarah; Franz, Nancy

2014-01-01

Examining traditional and contemporary professional development practices of youth-serving organizations can inform practices across Extension, particularly in light of the barriers that have been noted for effectively developing the professional competencies of Extension educators. With professional development systems changing quickly,…

Optimized ex-ovo culturing of chick embryos to advanced stages of development.

PubMed

Cloney, Kellie; Franz-Odendaal, Tamara Anne

2015-01-24

Research in anatomy, embryology, and developmental biology has largely relied on the use of model organisms. In order to study development in live embryos model organisms, such as the chicken, are often used. The chicken is an excellent model organism due to its low cost and minimal maintenance, however they present observational challenges because they are enclosed in an opaque eggshell. In order to properly view the embryo as it develops, the shell must be windowed or removed. Both windowing and ex ovo techniques have been developed to assist researchers in the study of embryonic development. However, each of the methods has limitations and challenges. Here, we present a simple, optimized ex ovo culture technique for chicken embryos that enables the observation of embryonic development from stage HH 19 into late stages of development (HH 40), when many organs have developed. This technique is easy to adopt in both undergraduate classes and more advanced research laboratories where embryo manipulations are conducted.

Numerous nanopores developed in organo-clay complexes during the shale formations

NASA Astrophysics Data System (ADS)

Wang, Q.; Wang, T.; Lu, H.; Liao, J.

2017-12-01

Shale gas as new energy resource is either stored in nano pores and microfractures or absorbed on the surface of kerogen and clay aggregate (Chalmers et al., 2012). Nano pores developed in organic matters is very important, because these organic pores have better connectivity than inorganic pores (Loucks et al., 2012) and can form an effective pore system where shale gas flows dominantly (Curtis et al., 2010). In order to figure out how the organic pores is affected by shale compositions, we conduct in-situ FE-SEM and EDS analysis on organic-rich Longmaxi shales. The data indicate that 1) organic matter, mixed with clay minerals, can form an organo-clay complex containing many nanopores; 2)furthermore, larger organic pores are developed in organo-clay complexes with higher clay content than in those with lower clay content(Wang et al., 2017). It seems that the presence of organo-clay complex raises the heterogeneous than pure organic matters. Organo-clay complex may bring in lots of intergranular nanopores between organic matter and clay minerals. Another potential interpretation is that clay minerals may influence kerogen thermal decomposition, generation of hydrocarbons and thus the development of organic pores. The presence of numerous nanopores in organo-clay complexes may promote the connectivity of the pore network and enhance the hydrocarbon production efficiency for shale gas field.

Embryonic Development of the Light Organ of the Sepiolid Squid Euprymna scolopes Berry.

PubMed

Montgomery, M K; McFall-Ngai, M

1993-06-01

The sepiolid squid Euprymna scolopes maintains luminous bacterial symbionts of the species Vibrio fischeri in a bilobed light organ partially embedded in the ventral surface of the ink sac. Anatomical and ultrastructural observations of the light organ during embryogenesis indicate that the organ begins development as a paired proliferation of the mesoderm of the hindgut-ink sac complex. Three-dimensional reconstruction of the incipient light organ of a newly hatched juvenile revealed the presence of three pairs of sacculate crypts, each crypt joined to a pore on the surface of the light organ by a ciliated duct. The crypts, which become populated with bacterial symbionts within hours after the juvenile hatches, appear to result from sequential paired invaginations of the surface epithelium of the hindgut-ink sac complex during embryogenesis. A pair of anterior and a pair of posterior ciliated epithelial appendages, which may facilitate infection of the incipient light organ with symbiotic bacteria, develop by extension and growth of the surface epithelium. The ink sac and reflector develop dorsal to the crypts and together function to direct luminescence ventrally. These two accessory tissues are present at the time of hatching, although changes in their overall structure accompany growth and maturation of the light organ. A third accessory tissue, the muscle-derived lens, appears during post-hatch maturation of the light organ.

Succession planning and leadership development: critical business strategies for healthcare organizations.

PubMed

Collins, Sandra K; Collins, Kevin S

2007-01-01

As labor shortages intensify, succession planning and leadership development have become strategic initiatives requiring rigorous consideration. Traditional methods of replacing personnel will not accommodate the vacancies expected to plague healthcare organizations. Managers should focus on identifying potential gaps of key personnel and adapting programs to accommodate organizational need. Attention should be placed on capturing the intellectual capital existent in the organization and developing diverse groups of leadership candidates.

A genetic screen for modifiers of UFO meristem activity identifies three novel FUSED FLORAL ORGANS genes required for early flower development in Arabidopsis.

PubMed

Levin, J Z; Fletcher, J C; Chen, X; Meyerowitz, E M

1998-06-01

In a screen to identify novel genes required for early Arabidopsis flower development, we isolated four independent mutations that enhance the Ufo phenotype toward the production of filamentous structures in place of flowers. The mutants fall into three complementation groups, which we have termed FUSED FLORAL ORGANS (FFO) loci. ffo mutants have specific defects in floral organ separation and/or positioning; thus, the FFO genes identify components of a boundary formation mechanism(s) acting between developing floral organ primordia. FFO1 and FFO3 have specific functions in cauline leaf/stem separation and in first- and third-whorl floral organ separation, with FFO3 likely acting to establish and FFO1 to maintain floral organ boundaries. FFO2 acts at early floral stages to regulate floral organ number and positioning and to control organ separation within and between whorls. Plants doubly mutant for two ffo alleles display additive phenotypes, indicating that the FFO genes may act in separate pathways. Plants doubly mutant for an ffo gene and for ufo, lfy, or clv3 reveal that the FFO genes play roles related to those of UFO and LFY in floral meristem initiation and that FFO2 and FFO3 may act to control cell proliferation late in inflorescence development.

Frogs as integrative models for understanding digestive organ development and evolution.

PubMed

Womble, Mandy; Pickett, Melissa; Nascone-Yoder, Nanette

2016-03-01

The digestive system comprises numerous cells, tissues and organs that are essential for the proper assimilation of nutrients and energy. Many aspects of digestive organ function are highly conserved among vertebrates, yet the final anatomical configuration of the gut varies widely between species, especially those with different diets. Improved understanding of the complex molecular and cellular events that orchestrate digestive organ development is pertinent to many areas of biology and medicine, including the regeneration or replacement of diseased organs, the etiology of digestive organ birth defects, and the evolution of specialized features of digestive anatomy. In this review, we highlight specific examples of how investigations using Xenopus laevis frog embryos have revealed insight into the molecular and cellular dynamics of digestive organ patterning and morphogenesis that would have been difficult to obtain in other animal models. Additionally, we discuss recent studies of gut development in non-model frog species with unique feeding strategies, such as Lepidobatrachus laevis and Eleutherodactylous coqui, which are beginning to provide glimpses of the evolutionary mechanisms that may generate morphological variation in the digestive tract. The unparalleled experimental versatility of frog embryos make them excellent, integrative models for studying digestive organ development across multiple disciplines. Copyright © 2016 Elsevier Ltd. All rights reserved.

Organ Printing

NASA Astrophysics Data System (ADS)

Cho, Dong-Woo; Lee, Jung-Seob; Jang, Jinah; Jung, Jin Woo; Park, Jeong Hun; Pati, Falguni

2015-10-01

This book introduces various 3D printing systems, biomaterials, and cells for organ printing. In view of the latest applications of several 3D printing systems, their advantages and disadvantages are also discussed. A basic understanding of the entire spectrum of organ printing provides pragmatic insight into the mechanisms, methods, and applications of this discipline. Organ printing is being applied in the tissue engineering field with the purpose of developing tissue/organ constructs for the regeneration of both hard (bone, cartilage, osteochondral) and soft tissues (heart). There are other potential application areas including tissue/organ models, disease/cancer models, and models for physiology and pathology, where in vitro 3D multicellular structures developed by organ printing are valuable.

Characteristics of Successful and Unsuccessful Organizational Development

DTIC Science & Technology

1975-03-01

aluminum, automobiles, glass, and household products . The development efforts in these organizations varied from organization to organization...Insurance 1 10 11 Automoti e 4 1 5 Petrochew cal 2 0 2 Censurer Household Products 1 1 2 Forrest Products 3 1 4 Conversion 0 1 1 15 the number of

A Student-Centered First-Semester Introductory Organic Laboratory Curriculum Facilitated by Microwave-Assisted Synthesis (MAOS)

ERIC Educational Resources Information Center

Russell, Cianán B.; Mason, Jeremy D.; Bean, Theodore G.; Murphree, S. Shaun

2014-01-01

An instructional laboratory curriculum for a first-semester introductory organic chemistry course has been developed using microwave-assisted organic synthesis (MAOS). Taking advantage of short reaction times, materials were developed to facilitate collaborative experimental design, analysis, and debriefing of results during the normal laboratory…

Designing Culturally Responsive Organized After-School Activities

ERIC Educational Resources Information Center

Simpkins, Sandra D.; Riggs, Nathaniel R.; Ngo, Bic; Vest Ettekal, Andrea; Okamoto, Dina

2017-01-01

Organized after-school activities promote positive youth development across a range of outcomes. To be most effective, organized activities need to meet high-quality standards. The eight features of quality developed by the National Research Council's Committee on Community-Level Programs for Youth have helped guide the field in this regard.…

Essentials for Successful Organization Development Efforts.

ERIC Educational Resources Information Center

Boss, R. Wayne

1979-01-01

The purpose of organization development (OD) is to improve an organization's effectiveness in making decisions and changes and to reach the full potential of its personnel. Objectives of OD and essentials for successful programs are listed. Definitions of essentials and how they add to the effectiveness of OD are presented. (Author/BEF)

Intermediaries Supporting Sports-Based Youth Development Programs

ERIC Educational Resources Information Center

Wicks, Anne; Beedy, Jeffrey P.; Spangler, Kathy J.; Perkins, Daniel F.

2007-01-01

The authors describe intermediary organizations whose aim is to provide technical assistance to sports organizations about infusing a youth development emphasis into their programming. Team-Up for Youth, Sports PLUS Global, and the National Recreation and Park Association are the three organizations highlighted in this article. Team-Up for Youth's…

Language Access Toolkit: An Organizing and Advocacy Resource for Community-Based Youth Programs

ERIC Educational Resources Information Center

Beyersdorf, Mark Ro

2013-01-01

Asian American Legal Defense and Education Fund (AALDEF) developed this language access toolkit to share the expertise and experiences of National Asian American Education Advocates Network (NAAEA) member organizations with other community organizations interested in developing language access campaigns. This toolkit includes an overview of…

Organic livestock production: an emerging opportunity with new challenges for producers in tropical countries.

PubMed

Chander, M; Subrahmanyeswari, B; Mukherjee, R; Kumar, S

2011-12-01

Agrochemicals, veterinary drugs, antibiotics and improved feeds can increase the food supply while minimising production costs in various livestock production systems around the world. However, these days, quality-conscious consumers are increasingly seeking environmentally safe, chemical-residue-free healthy foods, along with product traceability and a high standard of animal welfare, which organic production methods are said to ensure. Organic production is not only a challenge for producers in developing countries, it offers new export opportunities as well. Organic agriculture is practised by 1.8 million producers in 160 countries, and production of organically grown food continues to increase steadily by 15% per year. Most tropical countries are now exporting organic agricultural products but, apart from organic beef from Brazil and Argentina, organic livestock products are yetto take off. Most trade in organic livestock products is restricted to the European Union and other developed nations. Nevertheless, tropical countries cannot afford to neglect this emerging system of animal production. Organic production is knowledge- and management-intensive. Producers must be well versed in organic production standards, principles and practices, which require a high degree of knowledge and skill. In organic production, it is not simply the final product but the whole production process that must be inspected and approved by the accredited certification bodies. Organic livestock farming is still evolving, and further research is needed to make it sustainable. In this paper, the authors review the prospects of organic animal husbandry and its possible constraints in developing and tropical countries.

Evaluation of ecofriendly management practices of french beanrust (Uromyces appendiculatus) in organic farming system

NASA Astrophysics Data System (ADS)

Chhetry, G. K. N.; Mangang, H. C.

2012-09-01

Organic farming system emphasises on sustainable development of agriculture. The traditional agriculture system was much akin to the organic system but modernization of agriculture made a shift to this trend. The north east region of India is potential organic farming sites. Most of the farming systems are traditional and are organic by default; however crops in organic farming are prone to many fungal diseases. Hence for validation of the impact of organic practices on the disease development of plants, a study has been conducted for three years under natural environmental conditions on bean rust (Uromyces appendiculatus). Study includes ecofriendly practices like: plant extract treatment, intercropping of beans with maize, organic manure application, influence of cropping season and Trichoderma treatment. Rust is a major prevalent disease in the cultivation of beans as in other parts of the world. Detailed study of the disease in the organic environment and the impact of various treatments and agricultural agronomic practices would help in validation of the practices for the management of the disease in the organic farming system. In our study for three consecutive years it has been revealed that the practices of the traditional farmers likeplant extract application, intercropping, and manure application were found to have significant positive effects in reducing rust development in the bean fields. The treatment of farm yard manure resulted in development of lesser area under disease progress curve. The plant extract of Artemisia vulgaris has marked positive impact on reducing rust disease parameters. Foliar application of Trichoderma reduces the disease parameters of rust. This study would enhance information in understanding the impact of organic farming system on bean rust and would help in validitation of sustainable agricultural practices for use in organic farming system.

Optimizing IV and V for Mature Organizations

NASA Technical Reports Server (NTRS)

Fuhman, Christopher

2003-01-01

NASA is intending for its future software development agencies to have at least a Level 3 rating in the Carnegie Mellon University Capability Maturity Model (CMM). The CMM has built-in Verification and Validation (V&V) processes that support higher software quality. Independent Verification and Validation (IV&V) of software developed by mature agencies can be therefore more effective than for software developed by less mature organizations. How is Independent V&V different with respect to the maturity of an organization? Knowing a priori the maturity of an organization's processes, how can IV&V planners better identify areas of need choose IV&V activities, etc? The objective of this research is to provide a complementary set of guidelines and criteria to assist the planning of IV&V activities on a project using a priori knowledge of the measurable levels of maturity of the organization developing the software.

Sustainable development induction in organizations: a convergence analysis of ISO standards management tools' parameters.

PubMed

Merlin, Fabrício Kurman; Pereira, Vera Lúciaduarte do Valle; Pacheco, Waldemar

2012-01-01

Organizations are part of an environment in which they are pressured to meet society's demands and acting in a sustainable way. In an attempt to meet such demands, organizations make use of various management tools, among which, ISO standards are used. Although there are evidences of contributions provided by these standards, it is questionable whether its parameters converge for a possible induction for sustainable development in organizations. This work presents a theoretical study, designed on structuralism world view, descriptive and deductive method, which aims to analyze the convergence of management tools' parameters in ISO standards. In order to support the analysis, a generic framework for possible convergence was developed, based on systems approach, linking five ISO standards (ISO 9001, ISO 14001, OHSAS 18001, ISO 31000 and ISO 26000) with sustainable development and positioning them according to organization levels (strategic, tactical and operational). The structure was designed based on Brundtland report concept. The analysis was performed exploring the generic framework for possible convergence based on Nadler and Tushman model. The results found the standards can contribute to a possible sustainable development induction in organizations, as long as they meet certain minimum conditions related to its strategic alignment.

Simulation of wheat growth and development based on organ-level photosynthesis and assimilate allocation.

PubMed

Evers, J B; Vos, J; Yin, X; Romero, P; van der Putten, P E L; Struik, P C

2010-05-01

Intimate relationships exist between form and function of plants, determining many processes governing their growth and development. However, in most crop simulation models that have been created to simulate plant growth and, for example, predict biomass production, plant structure has been neglected. In this study, a detailed simulation model of growth and development of spring wheat (Triticum aestivum) is presented, which integrates degree of tillering and canopy architecture with organ-level light interception, photosynthesis, and dry-matter partitioning. An existing spatially explicit 3D architectural model of wheat development was extended with routines for organ-level microclimate, photosynthesis, assimilate distribution within the plant structure according to organ demands, and organ growth and development. Outgrowth of tiller buds was made dependent on the ratio between assimilate supply and demand of the plants. Organ-level photosynthesis, biomass production, and bud outgrowth were simulated satisfactorily. However, to improve crop simulation results more efforts are needed mechanistically to model other major plant physiological processes such as nitrogen uptake and distribution, tiller death, and leaf senescence. Nevertheless, the work presented here is a significant step forwards towards a mechanistic functional-structural plant model, which integrates plant architecture with key plant processes.

Patterns in the development of operations research and management science in government

NASA Technical Reports Server (NTRS)

White, M. J.

1971-01-01

The development of an operations research or management science (OR/MS) activity in an organization is discussed as occurring in a series of phases. Organizational aspects of the development of OR/MS in an individual case and in an institutional environment of federal civilian agencies are described. It is noted that there is some evidence that the length of time it takes an OR/MS group to develop to maturity has decreased. It is concluded that to understand the development of OR/MS in government organization, it must be considered as a problem in empirical organization theory.

A Factor Linking Floral Organ Identity and Growth Revealed by Characterization of the Tomato Mutant unfinished flower development (ufd).

PubMed

Poyatos-Pertíñez, Sandra; Quinet, Muriel; Ortíz-Atienza, Ana; Yuste-Lisbona, Fernando J; Pons, Clara; Giménez, Estela; Angosto, Trinidad; Granell, Antonio; Capel, Juan; Lozano, Rafael

2016-01-01

Floral organogenesis requires coordinated interactions between genes specifying floral organ identity and those regulating growth and size of developing floral organs. With the aim to isolate regulatory genes linking both developmental processes (i.e., floral organ identity and growth) in the tomato model species, a novel mutant altered in the formation of floral organs was further characterized. Under normal growth conditions, floral organ primordia of mutant plants were correctly initiated, however, they were unable to complete their development impeding the formation of mature and fertile flowers. Thus, the growth of floral buds was blocked at an early stage of development; therefore, we named this mutant as unfinished flower development ( ufd ). Genetic analysis performed in a segregating population of 543 plants showed that the abnormal phenotype was controlled by a single recessive mutation. Global gene expression analysis confirmed that several MADS-box genes regulating floral identity as well as other genes participating in cell division and different hormonal pathways were affected in their expression patterns in ufd mutant plants. Moreover, ufd mutant inflorescences showed higher hormone contents, particularly ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) and strigol compared to wild type. Such results indicate that UFD may have a key function as positive regulator of the development of floral primordia once they have been initiated in the four floral whorls. This function should be performed by affecting the expression of floral organ identity and growth genes, together with hormonal signaling pathways.

24 CFR 904.303 - Organizing the HBA.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Organizing the HBA. 904.303 Section 904.303 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

Linking Employee Development Activity, Social Exchange and Organizational Citizenship Behavior

ERIC Educational Resources Information Center

Pierce, Heather R.; Maurer, Todd J.

2009-01-01

The authors examined "perceived beneficiary" of employee development (self, organization) for relationships with employee development activity. Perceived organizational support served as a moderator. The authors conclude that employees may engage in development activities to partly benefit their organization to the extent that a positive exchange…

Key Considerations in Organizing and Structuring University Research

ERIC Educational Resources Information Center

Nguyen, T. L. Huong; Meek, Vincent Lynn

2015-01-01

University research capacity building has now become an increasingly important task in both developed and less developed countries. In this capacity building endeavour, research late-developer universities in particular need to develop a sound research organizational structure. However, what elements are needed in organizing and structuring…

Aposymbiotic culture of the sepiolid squid Euprymna scolopes: role of the symbiotic bacterium Vibrio fischeri in host animal growth, development, and light organ morphogenesis.

PubMed

Claes, M F; Dunlap, P V

2000-02-15

The sepiolid squid Euprymna scolopes forms a bioluminescent mutualism with the luminous bacterium Vibrio fischeri, harboring V. fischeri cells in a complex ventral light organ and using the bacterial light in predator avoidance. To characterize the contribution of V. fischeri to the growth and development of E. scolopes and to define the long-term effects of bacterial colonization on light organ morphogenesis, we developed a mariculture system for the culture of E. scolopes from hatching to adulthood, employing artificial seawater, lighting that mimicked that of the natural environment, and provision of prey sized to match the developmental stage of E. scolopes. Animals colonized by V. fischeri and animals cultured in the absence of V. fischeri (aposymbiotic) grew and survived equally well, developed similarly, and reached sexual maturity at a similar age. Development of the light organ accessory tissues (lens, reflectors, and ink sac) was similar in colonized and aposymbiotic animals with no obvious morphometric or histological differences. Colonization by V. fischeri influenced regression of the ciliated epithelial appendages (CEAs), the long-term growth of the light organ epithelial tubules, and the appearance of the cells composing the ciliated ducts, which exhibit characteristics of secretory tissue. In certain cases, aposymbiotic animals retained the CEAs in a partially regressed state and remained competent to initiate symbiosis with V. fischeri into adulthood. In other cases, the CEAs regressed fully in aposymbiotic animals, and these animals were not colonizable. The results demonstrate that V. fischeri is not required for normal growth and development of the animal or for development of the accessory light organ tissues and that morphogenesis of only those tissues coming in contact with the bacteria (CEAs, ciliated ducts, and light organ epithelium) is altered by bacterial colonization of the light organ. Therefore, V. fischeri apparently makes no major metabolic contribution to E. scolopes beyond light production, and post-embryonic development of the light organ is essentially symbiont independent. J. Exp. Zool. 286:280-296, 2000. Copyright 2000 Wiley-Liss, Inc.

NOVEL POLYMERIC MEMBRANE FOR DEHYDRATION OF ORGANIC SOLVENTS

EPA Science Inventory

Pervaporation has emerged as an economically viable alternative technology for dehydration of organic solvents, removal of organic compounds and organic/organic separations. Development of a membrane system with suitable flux and selectivity characteristics plays a critical role...

Bioengineered Lacrimal Gland Organ Regeneration in Vivo

PubMed Central

Hirayama, Masatoshi; Tsubota, Kazuo; Tsuji, Takashi

2015-01-01

The lacrimal gland plays an important role in maintaining a homeostatic environment for healthy ocular surfaces via tear secretion. Dry eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye disorders and causes ocular discomfort, significant visual disturbances, and a reduced quality of life. Current therapies for dry eye disease, including artificial tear eye drops, are transient and palliative. The lacrimal gland, which consists of acini, ducts, and myoepithelial cells, develops from its organ germ via reciprocal epithelial-mesenchymal interactions during embryogenesis. Lacrimal tissue stem cells have been identified for use in regenerative therapeutic approaches aimed at restoring lacrimal gland functions. Fully functional organ replacement, such as for tooth and hair follicles, has also been developed via a novel three-dimensional stem cell manipulation, designated the Organ Germ Method, as a next-generation regenerative medicine. Recently, we successfully developed fully functional bioengineered lacrimal gland replacements after transplanting a bioengineered organ germ using this method. This study represented a significant advance in potential lacrimal gland organ replacement as a novel regenerative therapy for dry eye disease. In this review, we will summarize recent progress in lacrimal regeneration research and the development of bioengineered lacrimal gland organ replacement therapy. PMID:26264034

Hospitals as learning organizations: fostering innovation through interactive learning.

PubMed

Dias, Casimiro; Escoval, Ana

2015-01-01

The article aims to provide an analytical understanding of hospitals as "learning organizations." It further analyzes the development of learning organizations as a way to enhance innovation and performance in the hospital sector. The article pulls together primary data on organizational flexibility, innovation, and performance from 95 administrators from hospital boards in Portugal, collected through a survey, interviews with hospital's boards, and a nominal group technique with a panel of experts on health systems. Results show that a combination of several organizational traits of the learning organization enhances its capacity for innovation development. The logistic model presented reveals that hospitals classified as "advanced learning organizations" have 5 times more chance of developing innovation than "basic learning organizations." Empirical findings further pointed out incentives, standards, and measurement requirements as key elements for integration of service delivery systems and expansion of the current capacity for structured and real-time learning in the hospital sector. The major implication arising from this study is that policy needs to combine instruments that promote innovation opportunities and incentives, with instruments stimulating the further development of the core components of learning organizations. Such a combination of policy instruments has the potential to ensure a wide external cooperation through a learning infrastructure.

Mitochondrial dysfunction in alveolar and white matter developmental failure in premature infants

PubMed Central

Ten, Vadim S.

2017-01-01

At birth, some organs in premature infants are not developed enough to meet challenges of the extra-uterine life. Although growth and maturation continues after premature birth, postnatal organ development may become sluggish or even arrested, leading to organ dysfunction. There is no clear mechanistic concept of this postnatal organ developmental failure in premature neonates. This review introduces a concept-forming hypothesis: Mitochondrial bioenergetic dysfunction is a fundamental mechanism of organs maturation failure in premature infants. Data collected in support of this hypothesis are relevant to two major diseases of prematurity: white matter injury and broncho-pulmonary dysplasia. In these diseases, totally different clinical manifestations are defined by the same biological process, developmental failure of the main functional units—alveoli in the lungs and axonal myelination in the brain. Although molecular pathways regulating alveolar and white matter maturation differ, proper bioenergetic support of growth and maturation remains critical biological requirement for any actively developing organ. Literature analysis suggests that successful postnatal pulmonary and white matter development highly depends on mitochondrial function which can be inhibited by sublethal postnatal stress. In premature infants, sublethal stress results mostly in organ maturation failure without excessive cellular demise. PMID:27901512

Mitochondrial dysfunction in alveolar and white matter developmental failure in premature infants.

PubMed

Ten, Vadim S

2017-02-01

At birth, some organs in premature infants are not developed enough to meet challenges of the extra-uterine life. Although growth and maturation continues after premature birth, postnatal organ development may become sluggish or even arrested, leading to organ dysfunction. There is no clear mechanistic concept of this postnatal organ developmental failure in premature neonates. This review introduces a concept-forming hypothesis: Mitochondrial bioenergetic dysfunction is a fundamental mechanism of organs maturation failure in premature infants. Data collected in support of this hypothesis are relevant to two major diseases of prematurity: white matter injury and broncho-pulmonary dysplasia. In these diseases, totally different clinical manifestations are defined by the same biological process, developmental failure of the main functional units-alveoli in the lungs and axonal myelination in the brain. Although molecular pathways regulating alveolar and white matter maturation differ, proper bioenergetic support of growth and maturation remains critical biological requirement for any actively developing organ. Literature analysis suggests that successful postnatal pulmonary and white matter development highly depends on mitochondrial function which can be inhibited by sublethal postnatal stress. In premature infants, sublethal stress results mostly in organ maturation failure without excessive cellular demise.

Organization-based self-development prescriptive model for the promotion of professional development of Iranian clinical nurses.

PubMed

Rahimaghaee, Flora; Nayeri, Nahid Dehghan; Mohammadi, Eesa; Salavati, Shahram

2015-01-01

Professional development is reiterated in the new definition of modern organizations as a serious undertaking of organizations. This article aims to present and describe a prescriptive model to increase the quality of professional development of Iranian nurses within an organization-based framework. This article is an outcome of the results of a study based on grounded theory describing how Iranian nurses develop. The present study adopted purposive sampling and the initial participants were experienced clinical nurses. Then, the study continued by theoretical sampling. The present study involved 21 participants. Data were mainly collected through interviews. Analysis began with open coding and continued with axial coding and selective coding. Trustworthiness was ensured by applying Lincoln and Guba criteria such as credibility, dependability, and conformability. Based on the data gathered in the study and a thorough review of related literature, a prescriptive model has been designed by use of the methodology of Walker and Avant (2005). In this model, the first main component is a three-part structure: Reformation to establish a value-assigning structure, a position for human resource management, and a job redesigning. The second component is certain of opportunities for organization-oriented development. These strategies are as follows: Raising the sensitivity of the organization toward development, goal setting and planning the development of human resources, and improving management practices. Through this model, clinical nurses' professional development can transform the profession from an individual, randomized activity into more planned and systematized services. This model can lead to a better quality of care.

Organization-based self-development prescriptive model for the promotion of professional development of Iranian clinical nurses

PubMed Central

Rahimaghaee, Flora; Nayeri, Nahid Dehghan; Mohammadi, Eesa; Salavati, Shahram

2015-01-01

Background: Professional development is reiterated in the new definition of modern organizations as a serious undertaking of organizations. This article aims to present and describe a prescriptive model to increase the quality of professional development of Iranian nurses within an organization-based framework. Materials and Methods: This article is an outcome of the results of a study based on grounded theory describing how Iranian nurses develop. The present study adopted purposive sampling and the initial participants were experienced clinical nurses. Then, the study continued by theoretical sampling. The present study involved 21 participants. Data were mainly collected through interviews. Analysis began with open coding and continued with axial coding and selective coding. Trustworthiness was ensured by applying Lincoln and Guba criteria such as credibility, dependability, and conformability. Based on the data gathered in the study and a thorough review of related literature, a prescriptive model has been designed by use of the methodology of Walker and Avant (2005). Results: In this model, the first main component is a three-part structure: Reformation to establish a value-assigning structure, a position for human resource management, and a job redesigning. The second component is certain of opportunities for organization-oriented development. These strategies are as follows: Raising the sensitivity of the organization toward development, goal setting and planning the development of human resources, and improving management practices. Conclusions: Through this model, clinical nurses’ professional development can transform the profession from an individual, randomized activity into more planned and systematized services. This model can lead to a better quality of care. PMID:26457100

Principles for interactions with biopharmaceutical companies: the development of guidelines for patient advocacy organizations in the field of rare diseases.

PubMed

Stein, Susan; Bogard, Elizabeth; Boice, Nicole; Fernandez, Vivian; Field, Tessa; Gilstrap, Alan; Kahn, Susan R; Larkindale, Jane; Mathieson, Toni

2018-01-22

Rare diseases are a global public health concern, affecting an estimated 350 million individuals. Only 5% of approximately 7000 known rare diseases have a treatment, and only about half have a patient advocacy organization. Biopharmaceutical companies face complex challenges in developing treatments for rare diseases. Patient advocacy organizations may play a major role by positively influencing research and development, clinical trials, and regulations. Thus, collaboration among patient advocacy organizations and industry is essential to bring new therapeutics to patients. We identified an unmet need for guidelines on day-to-day decision-making by rare disease patient advocacy organizations when working with biopharmaceutical partners. We convened an Independent Expert Panel experienced in collaborations between patient advocacy organizations and biopharmaceutical companies (April 2017) to develop consensus guidelines for these relationships. The guidelines were based on an original version by the International Fibrodysplasia Ossificans Progressiva Association (IFOPA). The Expert Panel reviewed and broadened these to be applicable to all patient advocacy organizations. Comments on the draft Guidelines were provided first by Panel participants and subsequently by six independent experts from patient advocacy organizations and industry. The Panel comprised four experts from the rare disease community who lead patient advocacy organizations; three leaders who perform advocacy functions within biopharmaceutical companies; and two facilitators, both having leadership experience in rare diseases and industry. The finalized Guidelines consist of four main sections: Identification and Engagement With Companies, Patient Engagement and Patient Privacy, Financial Contributions, and Clinical Trial Communication and Support. The Guidelines address the daily considerations, choices, and consequences of patient advocacy organizations as they engage with biopharmaceutical companies, and offer recommendations for volunteer/paid leaders of the organizations on how to interact in a thoughtful, responsible, ethical way that engenders trust. These Guidelines recommend best practices and standards for interactions between patient advocacy organizations and industry that will ultimately have a positive effect on the development of novel treatments. Patient advocacy organizations will be provided free access to these Guidelines to help bring clarification to day-to-day decision-making around their interactions, and for use as a living document with the potential for regular revisions and updates.

Partnership Among Peers: Lessons Learned From the Development of a Community Organization-Academic Research Training Program.

PubMed

Jewett-Tennant, Jeri; Collins, Cyleste; Matloub, Jacqueline; Patrick, Alison; Chupp, Mark; Werner, James J; Borawski, Elaine A

2016-01-01

Community engagement and rigorous science are necessary to address health issues. Increasingly, community health organizations are asked to partner in research. To strengthen such community organization-academic partnerships, increase research capacity in community organizations, and facilitate equitable partnered research, the Partners in Education Evaluation and Research (PEER) program was developed. The program implements an 18-month structured research curriculum for one mid-level employee of a health-focused community-based organization with an organizational mentor and a Case Western Reserve University faculty member as partners. The PEER program was developed and guided by a community-academic advisory committee and was designed to impact the research capacity of organizations through didactic modules and partnered research in the experiential phase. Active participation of community organizations and faculty during all phases of the program provided for bidirectional learning and understanding of the challenges of community-engaged health research. The pilot program evaluation used qualitative and quantitative data collection techniques, including experiences of the participants assessed through surveys, formal group and individual interviews, phone calls, and discussions. Statistical analysis of the change in fellows' pre-test and post-test survey scores were conducted using paired sample t tests. The small sample size is recognized by the authors as a limitation of the evaluation methods and would potentially be resolved by including more cohort data as the program progresses. Qualitative data were reviewed by two program staff using content and narrative analysis to identify themes, describe and assess group phenomena and determine program improvements. The objective of PEER is to create equitable partnerships between community organizations and academic partners to further research capacity in said organizations and develop mutually beneficial research partnerships between academia and community organizations. PEER demonstrates a commitment to successfully developing sustainable research capacity growth in community organizations, and improved partnered research with academic institutions.

78 FR 38361 - Announcement of Funding Awards for the Rural Capacity Building for Community Development and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

... business and administrative capabilities of rural community-based housing development organizations, CDCs... community-based housing development organizations, CDCs, CHDOs, and local governments in addition to Indian... Awards for the Rural Capacity Building for Community Development and Affordable Housing Program Fiscal...

Lessons for Staff Developers from an Organization Development Intervention.

ERIC Educational Resources Information Center

Conway, James A.

1990-01-01

A case study of an organization development intervention in a large New York State school district describes to staff developers the complex process of discovering and responding to organizational needs. The discussion focuses on understanding the problem; frameworks for diagnosis and intervention; and implementing the intervention strategy.…

Capacity development for knowledge translation: evaluation of an experiential approach through secondment opportunities.

PubMed

Gerrish, Kate; Piercy, Hilary

2014-06-01

Experiential approaches to skills development using secondment models are shown to benefit healthcare organizations more generally, but little is known about the potential of this approach to develop capacity for knowledge translation (KT). To evaluate the success of KT capacity development secondments from the perspective of multiple stakeholders. A pluralistic evaluation design was used. Data were collected during 2011-2012 using focus group and individual interviews with 14 clinical and academic secondees, and five managers from host and seconding organizations to gain insight into participants' perceptions of the success of secondments and the criteria by which they judged success. Six After Action Reviews were undertaken with KT project teams to explore participants' perceptions of the contribution secondees made to KT projects. Semistructured interviews were undertaken with three healthcare managers on completion of projects to explore the impact of secondments on the organization, staff, and patients. Qualitative content analysis was used to identify criteria for success. The criteria provided a framework through which the overall success of secondments could be judged. Six criteria for judging the success of the secondments at individual, team, and organization level were identified: KT skills development, effective workload management, team working, achieving KT objectives, enhanced care delivery, and enhanced education delivery. Benefits to the individual, KT team, seconding, and host organizations were identified. Hosting teams should provide mentorship support to secondees, and be flexible to accommodate secondees' needs as team members. Ongoing support of managers from seconding organizations is needed to maximize the benefits to individual secondees and the organization. Experiential approaches to KT capacity development using secondments can benefit individual secondees, project teams, seconding, and host organizations. © 2014 Sigma Theta Tau International.

[The cell theory. Progress in studies on cell-cell communications].

PubMed

Brodskiĭ, V Ia

2009-01-01

Current data confirm the fundamental statement of the cell theory concerning the cell reproduction in a series of generations (omnis cellula e cellula). Cell communities or ensembles integrated by the signaling systems established in prokaryotes and protists and functioning in multicellular organisms including mammals are considered as the structural and functional unit of a multicellular organism. The cell is an elementary unit of life and basis of organism development and functioning. At the same time, the adult organism is not just a totality of cells. Multinucleated cells in some tissues, syncytial structure, and structural-functional units of organs are adaptations for optimal functioning of the multicellular organism and manifestations of cell-cell communications in development and definitive functioning. The cell theory was supplemented and developed by studies on cell-cell communications; however, these studies do not question the main generalizations of the theory.

Developing the field of youth organizing and advocacy: what foundations can do.

PubMed

Yee, Sylvia M

2008-01-01

For more than a decade, the Evelyn and Walter Haas, Jr. Fund has seeded many San Francisco Bay Area youth organizing and advocacy programs. Now that the field is maturing, argues the fund's vice president of programs, foundations have a critical programmatic and capacity-building role to play. The author offers analysis and strategies for integrating youth development grant making across foundation interest areas. The programs described illustrate the diversity of youth organizing and advocacy programs that could be supported by funders, whether or not any particular philanthropic institution has a grant-making focus on youth development or youth organizing. The article ends with an in-depth portrait of the self-reported needs of youth organizing and advocacy programs and concrete strategies for foundations seeking to more effectively enable youth organizing and advocacy to play an important role in bringing about a more vibrant, diverse, and effective democratic culture.

Microengineered physiological biomimicry: organs-on-chips.

PubMed

Huh, Dongeun; Torisawa, Yu-suke; Hamilton, Geraldine A; Kim, Hyun Jung; Ingber, Donald E

2012-06-21

Microscale engineering technologies provide unprecedented opportunities to create cell culture microenvironments that go beyond current three-dimensional in vitro models by recapitulating the critical tissue-tissue interfaces, spatiotemporal chemical gradients, and dynamic mechanical microenvironments of living organs. Here we review recent advances in this field made over the past two years that are focused on the development of 'Organs-on-Chips' in which living cells are cultured within microfluidic devices that have been microengineered to reconstitute tissue arrangements observed in living organs in order to study physiology in an organ-specific context and to develop specialized in vitro disease models. We discuss the potential of organs-on-chips as alternatives to conventional cell culture models and animal testing for pharmaceutical and toxicology applications. We also explore challenges that lie ahead if this field is to fulfil its promise to transform the future of drug development and chemical safety testing.

Inspiration from heart development: Biomimetic development of functional human cardiac organoids.

PubMed

Richards, Dylan J; Coyle, Robert C; Tan, Yu; Jia, Jia; Wong, Kerri; Toomer, Katelynn; Menick, Donald R; Mei, Ying

2017-10-01

Recent progress in human organoids has provided 3D tissue systems to model human development, diseases, as well as develop cell delivery systems for regenerative therapies. While direct differentiation of human embryoid bodies holds great promise for cardiac organoid production, intramyocardial cell organization during heart development provides biological foundation to fabricate human cardiac organoids with defined cell types. Inspired by the intramyocardial organization events in coronary vasculogenesis, where a diverse, yet defined, mixture of cardiac cell types self-organizes into functional myocardium in the absence of blood flow, we have developed a defined method to produce scaffold-free human cardiac organoids that structurally and functionally resembled the lumenized vascular network in the developing myocardium, supported hiPSC-CM development and possessed fundamental cardiac tissue-level functions. In particular, this development-driven strategy offers a robust, tunable system to examine the contributions of individual cell types, matrix materials and additional factors for developmental insight, biomimetic matrix composition to advance biomaterial design, tissue/organ-level drug screening, and cell therapy for heart repair. Copyright © 2017 Elsevier Ltd. All rights reserved.

Problems of innovative development of an entrepreneurship in the industry in the conditions of upgrade of Economy

NASA Astrophysics Data System (ADS)

Golubetskaya, Natalya; Kosheleva, Tatyana; Kunin, Vladimir

2017-10-01

Innovative development of economy is a necessary condition for increase of competitiveness of Russia. Organization change should pass consistently taking into account a strategic target of development of the Russian economy as a whole. The analysis of work of the large innovatively focused corporations has shown that an important direction of formation of system of innovative activity in Russia is development of interaction, integration of large and small enterprise structures, entrepreneurs in the sphere of transportation, transportation or energy companies and educational institutions in this sphere. Stopping development threatens the organization with the stagnation, therefore each organization the plans for development directed on formation of competitive advantages of the transportation or energy company - strategy are developed. The work offers guidelines for managing the modernization of the educational process. Formulates the stages of organizational changes in the educational business organizations. Recommendations for formation in the educational enterprise structures matrix management innovation are given.

75 FR 61503 - Cooperative Agreement With the World Health Organization for a Plan to Develop a Global...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... and stakeholders. C. Eligibility Information The following organizations/institutions are eligible to...] Cooperative Agreement With the World Health Organization for a Plan to Develop a Global Integrated Food Safety Information Platform AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug...

The Organization for Economic Cooperation and Development: Functional Literacy and Corporate Agendas.

ERIC Educational Resources Information Center

Hyslop-Margison, Emery J.; Margison, Judith Ann

This paper examines the conception of functional literacy advanced by the Organization for Economic Cooperation and Development (OECD), a 29-member organization of leading industrialized countries, as part of its 1994 International Adult Literacy Survey (IALS). The paper suggests that embedded within this conception of literacy and the discourse…

Teacher Activist Organizations and the Development of Professional Agency

ERIC Educational Resources Information Center

Quinn, Rand; Carl, Nicole Mittenfelner

2015-01-01

Teacher professional agency refers to the ability of teachers to control their work within structural constraints. In this paper, we show how teacher activist organizations can assist in the development of professional agency. We focus on a teacher activist organization in a large urban district in the United States and identify three…

Integration of a Faculty's Ongoing Research into an Undergraduate Laboratory Teaching Class in Developmental Biology

ERIC Educational Resources Information Center

Nam, Sang-Chul

2018-01-01

Traditional developmental biology laboratory classes have utilized a number of different model organisms to allow students to be exposed to diverse biological phenomena in developing organisms. This traditional approach has mainly focused on the diverse morphological and anatomical descriptions of the developing organisms. However, modern…

Organic Horticulture in the Secondary School

ERIC Educational Resources Information Center

Marrocco, Aldo

2009-01-01

This report is based on five years experience working with primary and secondary school teachers in Italy to develop organic farming as an activity for students. The tasks involved were intended to develop our students' environmental awareness, allow them to produce food organically and show that market gardening could be a productive hobby. In…

Organization Development: Its Nature, Origins, and Prospects.

ERIC Educational Resources Information Center

Bennis, Warren G.

A primer on organization development (OD), this book presents a basic statement for people in organizations and for practitioners and students of OD. Many concrete examples are included. After a definition of OD, the basic conditions which create the need for OD are discussed: rapid change, growth in size, increasing diversity, change in…

Tailoring Consultation in Organization Development for Particular Schools. An Occasional Paper.

ERIC Educational Resources Information Center

Schmuck, Richard; And Others

This paper discusses characteristics of school organizations and strategies of organization development (OD) consultation as they relate to organizational change in schools. The basic premise of the paper is that any OD intervention in a school should be a somewhat unique series of events specifically tailored to the needs and characteristics of…

Process Consultation: Its Role in Organization Development.

ERIC Educational Resources Information Center

Schein, Edgar H.

This volume focuses on the process by which the consultant builds readiness for organizational development (OD) programs, actually conducts training, and works with the key individuals of an organization as part of an OD program. Part I describes in some detail the human processes in organizations--communication, functional roles of group members,…

Use of Graphic Organizers in a Language Teachers' Professional Development

ERIC Educational Resources Information Center

Chien, Chin-Wen

2012-01-01

Starting from 2009 academic year, the instructional coaches in a school district in a northwest American city began to provide Workshop II (pseudonym) to elementary school English teachers. This study aims to discuss the use of graphic organizers in English teachers' professional development. Different types of graphic organizers such as…

Institutionalization of Technology Transfer Organizations in Chinese Universities

ERIC Educational Resources Information Center

Cai, Yuzhuo; Zhang, Han; Pinheiro, Rómulo

2015-01-01

There is a lack of in-depth studies on how technology transfer organizations (TTOs) are organized and developed. This paper examines the evolution/institutionalization of TTOs in Tsinghua University (TU), as a microcosm of the development of TTOs in Chinese universities. It explores two issues in particular: what kinds of TTOs have been developed…

Interweaving Youth Development, Community Development, and Social Change through Youth Organizing

ERIC Educational Resources Information Center

Christens, Brian D.; Dolan, Tom

2011-01-01

Community organizing groups that have built coalitions for local change over the past few decades are now involving young people as leaders in efforts to improve quality of life. The current study explores a particularly effective youth organizing initiative through review of organizational documents and collection and analysis of qualitative…

Protein and metabolic engineering for the production of organic acids.

PubMed

Liu, Jingjing; Li, Jianghua; Shin, Hyun-Dong; Liu, Long; Du, Guocheng; Chen, Jian

2017-09-01

Organic acids are natural metabolites of living organisms. They have been widely applied in the food, pharmaceutical, and bio-based materials industries. In recent years, biotechnological routes to organic acids production from renewable raw materials have been regarded as very promising approaches. In this review, we provide an overview of current developments in the production of organic acids using protein and metabolic engineering strategies. The organic acids include propionic acid, pyruvate, itaconic acid, succinic acid, fumaric acid, malic acid and citric acid. We also expect that rapid developments in the fields of systems biology and synthetic biology will accelerate protein and metabolic engineering for microbial organic acid production in the future. Copyright © 2017. Published by Elsevier Ltd.

Development and comparison of computational models for estimation of absorbed organ radiation dose in rainbow trout (Oncorhynchus mykiss) from uptake of iodine-131.

PubMed

Martinez, N E; Johnson, T E; Capello, K; Pinder, J E

2014-12-01

This study develops and compares different, increasingly detailed anatomical phantoms for rainbow trout (Oncorhynchus mykiss) for the purpose of estimating organ absorbed radiation dose and dose rates from (131)I uptake in multiple organs. The models considered are: a simplistic geometry considering a single organ, a more specific geometry employing additional organs with anatomically relevant size and location, and voxel reconstruction of internal anatomy obtained from CT imaging (referred to as CSUTROUT). Dose Conversion Factors (DCFs) for whole body as well as selected organs of O. mykiss were computed using Monte Carlo modeling, and combined with estimated activity concentrations, to approximate dose rates and ultimately determine cumulative radiation dose (μGy) to selected organs after several half-lives of (131)I. The different computational models provided similar results, especially for source organs (less than 30% difference between estimated doses), and whole body DCFs for each model (∼3 × 10(-3) μGy d(-1) per Bq kg(-1)) were comparable to DCFs listed in ICRP 108 for (131)I. The main benefit provided by the computational models developed here is the ability to accurately determine organ dose. A conservative mass-ratio approach may provide reasonable results for sufficiently large organs, but is only applicable to individual source organs. Although CSUTROUT is the more anatomically realistic phantom, it required much more resource dedication to develop and is less flexible than the stylized phantom for similar results. There may be instances where a detailed phantom such as CSUTROUT is appropriate, but generally the stylized phantom appears to be the best choice for an ideal balance between accuracy and resource requirements. Copyright © 2014 Elsevier Ltd. All rights reserved.

Child organ trafficking: global reality and inadequate international response.

PubMed

Bagheri, Alireza

2016-06-01

In organ transplantation, the demand for human organs has grown far faster than the supply of organs. This has opened the door for illegal organ trade and trafficking including from children. Organized crime groups and individual organ brokers exploit the situation and, as a result, black markets are becoming more numerous and organized organ trafficking is expanding worldwide. While underprivileged and vulnerable men and women in developing countries are a major source of trafficked organs, and may themselves be trafficked for the purpose of illegal organ removal and trade, children are at especial risk of exploitation. With the confirmed cases of children being trafficked for their organs, child organ trafficking, which once called a "modern urban legend", is a sad reality in today's world. By presenting a global picture of child organ trafficking, this paper emphasizes that child organ trafficking is no longer a myth but a reality which has to be addressed. It argues that the international efforts against organ trafficking and trafficking in human beings for organ removal have failed to address child organ trafficking adequately. This chapter suggests that more orchestrated international collaboration as well as development of preventive measure and legally binding documents are needed to fight child organ trafficking and to support its victims.

Role of nanotechnology in development of artificial organs.

PubMed

Teoh, G Z; Klanrit, P; Kasimatis, M; Seifalian, A M

2015-02-01

Improvements in our understanding of the interactions between implants and cells have directed attention towards nanoscale technologies. To date, nanotechnology has played a helping hand in the development of synthetic artificial organs and regenerative medicine. This includes the production of smart nanocomposite materials; fluorescent nanoparticles like Quantum Dots (QD) and magnetic nano particles (MNP) for stem cell tracking; and carbon nanotubes (CNT) and graphene for enhancement of material properties. The scope of this paper includes the role of nanoparticles in the development of nanomaterials; the chemical surface modifications possible to improve implant function and an overview of the performance of nano-engineered organs thus far. This includes implants developed for aesthetic purposes like nasal and auricular scaffolds, plastic and reconstructive surgical constructs (i.e. dermal grafts), hollow organs for cardiothoracic applications; and last but not least, orthopedic implants. The five-year outlook for nano-enhanced artificial organs is also discussed, highlighting the key research and development areas, available funds and the hurdles we face in accomplishing progression from prototypes on the laboratory bench to off-the-shelf products for the consumer market. Ultimately, this review aims to delineate the advantages of incorporating nanotechnology, as an individual entity or as a part of a construct for the development of tissue engineering scaffolds and/or artificial organs, and unravel the mechanisms of tissue cell-biomaterial interactions at the nanoscale, allowing for better progress in the development and optimization of unique nanoscale surface features for a wide range of applications.

[Concomitant impact of organic pathology on the development of cognitive impairment in patients with attack-like paranoid schizophrenia].

PubMed

Libin, L Ia; Tagil'tseva, A V; Lifanova, D E; Ganzenko, M A; Gritsevskaia, T M; Ivanov, M B

2014-01-01

The study included 47 patients (23 men, 24 women) with ICD-10 diagnosis of attack-like paranoid schizophrenia. Patients were divided into two groups: with- (25 patients) or without (22 patients) a concomitant organic disease. Memory, attention and thinking were assessed with psychometric tests. Inter- and intra-group differences were identified that indicated a considerable impact of a concomitant CNS organic pathology on the development of cognitive impairment in the schizophrenic process and active antipsychotic therapy. The data obtained can be used in the development of a differentiated approach to the treatment of patients with concomitant organic pathology.

The Psychology of Sustainability and Sustainable Development for Well-Being in Organizations.

PubMed

Di Fabio, Annamaria

2017-01-01

This article discusses the contribution of the psychology of sustainability and sustainable development to well-being in organizations from a primary prevention perspective. It deals with sustainability not only in terms of the ecological, economic, and social environment but also in terms of improving the quality of life of every human being. The psychology of sustainability and sustainable development is seen as a primary prevention perspective that can foster well-being in organizations at all the different levels going from the worker, to the group, to the organization, and also to inter-organizational processes. The possibilities for further research and interventions are also discussed.

The Psychology of Sustainability and Sustainable Development for Well-Being in Organizations

PubMed Central

Di Fabio, Annamaria

2017-01-01

This article discusses the contribution of the psychology of sustainability and sustainable development to well-being in organizations from a primary prevention perspective. It deals with sustainability not only in terms of the ecological, economic, and social environment but also in terms of improving the quality of life of every human being. The psychology of sustainability and sustainable development is seen as a primary prevention perspective that can foster well-being in organizations at all the different levels going from the worker, to the group, to the organization, and also to inter-organizational processes. The possibilities for further research and interventions are also discussed. PMID:28974935

Using Physical Organic Chemistry To Shape the Course of Electrochemical Reactions.

PubMed

Moeller, Kevin D

2018-05-09

While organic electrochemistry can look quite different to a chemist not familiar with the technique, the reactions are at their core organic reactions. As such, they are developed and optimized using the same physical organic chemistry principles employed during the development of any other organic reaction. Certainly, the electron transfer that triggers the reactions can require a consideration of new "wrinkles" to those principles, but those considerations are typically minimal relative to the more traditional approaches needed to manipulate the pathways available to the reactive intermediates formed downstream of that electron transfer. In this review, three very different synthetic challenges-the generation and trapping of radical cations, the development of site-selective reactions on microelectrode arrays, and the optimization of current in a paired electrolysis-are used to illustrate this point.

Human rights and religious backlash: the experience of a Bangladeshi NGO.

PubMed

Rafi, M; Chowdhury, A M

2000-02-01

As part of a human rights education campaign, the Bangladesh Rural Advancement Committee fixed 700,000 posters throughout Bangladesh. This met with opposition from the religious organizations. This paper investigates the nature and cause of the backlash and sets out strategies for how development organizations can achieve their objectives in the face of opposition. The opposition was found to be in response to interpretations of the posters based on the Holy Koran and Islamic practices, and a perceived intrusion into the professional territory of religious organizations, which affected the socioeconomic interests of these organizations' representatives. It was therefore concluded that development organizations should pre-empt such opposition by spelling out their objectives to potential critics, and formulating programs that do not provide scope for opponents to undermine their development activities.

Management, leadership, and user control in self-advocacy: an english case study.

PubMed

Tilley, Elizabeth

2013-12-01

This paper presents findings from a qualitative research project on an English self-advocacy organization. In light of recent political and economic developments that have threatened the sustainability of a number of self-advocacy groups for people with intellectual disability, I seek to explore how one particular organization managed to survive and grow. In particular, the paper explores themes of management, leadership, and user control, linking these to external perceptions about self-advocacy organizations. The organization in my study developed an "interdependent" governance model based on key organizational roles for nondisabled advisors and self-advocates, which proved popular with external funders. Despite the organization's notable achievements, its success raises questions for the wider self-advocacy movement, notably how leadership capacity can be developed among self-advocates.

Heterogeneous Monolithic Integration of Single-Crystal Organic Materials.

PubMed

Park, Kyung Sun; Baek, Jangmi; Park, Yoonkyung; Lee, Lynn; Hyon, Jinho; Koo Lee, Yong-Eun; Shrestha, Nabeen K; Kang, Youngjong; Sung, Myung Mo

2017-02-01

Manufacturing high-performance organic electronic circuits requires the effective heterogeneous integration of different nanoscale organic materials with uniform morphology and high crystallinity in a desired arrangement. In particular, the development of high-performance organic electronic and optoelectronic devices relies on high-quality single crystals that show optimal intrinsic charge-transport properties and electrical performance. Moreover, the heterogeneous integration of organic materials on a single substrate in a monolithic way is highly demanded for the production of fundamental organic electronic components as well as complex integrated circuits. Many of the various methods that have been designed to pattern multiple heterogeneous organic materials on a substrate and the heterogeneous integration of organic single crystals with their crystal growth are described here. Critical issues that have been encountered in the development of high-performance organic integrated electronics are also addressed. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Policy Transfer Among Regional-Level Organizations: Insights from Source Water Protection in Ontario.

PubMed

de Loë, R C; Murray, D; Michaels, S; Plummer, R

2016-07-01

Organizations at the local and regional scales often face the challenge of developing policy mechanisms rapidly and concurrently, whether in response to expanding mandates, newly identified threats, or changes in the political environment. In the Canadian Province of Ontario, rapid, concurrent policy development was considered desirable by 19 regional organizations tasked with developing policies for protection of drinking water sources under very tight and highly prescribed mandates. An explicit policy transfer approach was used by these organizations. Policy transfer refers to using knowledge of policies, programs, and institutions in one context in the development of policies, programs, and institutions in another. This paper assesses three online mechanisms developed to facilitate policy transfer for source water protection in Ontario. Insights are based on a survey of policy planners from the 19 regional organizations who used the three policy transfer tools, supplemented by an analysis of three policies created and transferred among the 19 regional source water protection organizations. Policy planners in the study indicated they had used policy transfer to develop source protection policies for their regions-a finding confirmed by analysis of the text of policies. While the online policy transfer tools clearly facilitated systematic policy transfer, participants still preferred informal, direct exchanges with their peers in other regions over the use of the internet-based policy transfer mechanisms created on their behalf.

Origins of organic geochemistry

USGS Publications Warehouse

Kvenvolden, K.A.

2008-01-01

When organic geochemistry actually began as a recognized geoscience is a matter of definition and perspective. Constraints on its beginning are placed by the historical development of its parent disciplines, geology and organic chemistry. These disciplines originated independently and developed in parallel, starting in the latter half of the 18th century and flourishing thereafter into the 21st century. Organic geochemistry began sometime between 1860 and 1983; I argue that 1930 is the best year to mark its origin.

Physicians in health care management: 9. Strategic alliances and relationships between organizations.

PubMed Central

Leatt, P; Barnsley, J

1994-01-01

Health care organizations must increasingly develop strategic alliances with other groups and organizations. A variety of interorganizational relationships are possible: shared services, joint programs, umbrella organizations, health agency networks and mergers. As governments try to control health care costs, physicians will play an important role in developing and implementing these alliances. They will be expected to advocate on behalf of patients and communities to ensure that these new organizational arrangements facilitate coordinated care. PMID:8087752

Superintendent Succession: The Impact of Applying Succession Management Strategies, Developing District Leaders and Promoting from within an Organization on the Self-Perceived Degree of Preparation and Job Effectiveness of First-Time Pennsylvania Superintendents

ERIC Educational Resources Information Center

Gildea, Robert J.

2012-01-01

The leader, more than any other individual in an organization, has a profound impact upon that organization's success. Whether in the business sector or public education, it is nearly impossible for an organization to acquire and sustain success without strong leadership. Many businesses go to great lengths to develop individuals with leadership…

Functional conjugated pyridines via main-group element tuning.

PubMed

Stolar, Monika; Baumgartner, Thomas

2018-03-29

Pyridine-based materials have seen widespread attention for the development of n-type organic materials. In recent years, the incorporation of main-group elements has also explored significant advantages for the development and tunability of organic conjugated materials. The unique chemical and electronic structure of main-group elements has led to several enhancements in conventional organic materials. This Feature article highlights recent main-group based pyridine materials by discussing property enhancements and application in organic electronics.

A genetic screen for modifiers of UFO meristem activity identifies three novel FUSED FLORAL ORGANS genes required for early flower development in Arabidopsis.

PubMed Central

Levin, J Z; Fletcher, J C; Chen, X; Meyerowitz, E M

1998-01-01

In a screen to identify novel genes required for early Arabidopsis flower development, we isolated four independent mutations that enhance the Ufo phenotype toward the production of filamentous structures in place of flowers. The mutants fall into three complementation groups, which we have termed FUSED FLORAL ORGANS (FFO) loci. ffo mutants have specific defects in floral organ separation and/or positioning; thus, the FFO genes identify components of a boundary formation mechanism(s) acting between developing floral organ primordia. FFO1 and FFO3 have specific functions in cauline leaf/stem separation and in first- and third-whorl floral organ separation, with FFO3 likely acting to establish and FFO1 to maintain floral organ boundaries. FFO2 acts at early floral stages to regulate floral organ number and positioning and to control organ separation within and between whorls. Plants doubly mutant for two ffo alleles display additive phenotypes, indicating that the FFO genes may act in separate pathways. Plants doubly mutant for an ffo gene and for ufo, lfy, or clv3 reveal that the FFO genes play roles related to those of UFO and LFY in floral meristem initiation and that FFO2 and FFO3 may act to control cell proliferation late in inflorescence development. PMID:9611175

An official American Thoracic Society/International Society for Heart and Lung Transplantation/Society of Critical Care Medicine/Association of Organ and Procurement Organizations/United Network of Organ Sharing Statement: ethical and policy considerations in organ donation after circulatory determination of death.

PubMed

Gries, Cynthia J; White, Douglas B; Truog, Robert D; Dubois, James; Cosio, Carmen C; Dhanani, Sonny; Chan, Kevin M; Corris, Paul; Dark, John; Fulda, Gerald; Glazier, Alexandra K; Higgins, Robert; Love, Robert; Mason, David P; Nakagawa, Thomas A; Shapiro, Ron; Shemie, Sam; Tracy, Mary Fran; Travaline, John M; Valapour, Maryam; West, Lori; Zaas, David; Halpern, Scott D

2013-07-01

Donation after circulatory determination of death (DCDD) has the potential to increase the number of organs available for transplantation. Because consent and management of potential donors must occur before death, DCDD raises unique ethical and policy issues. To develop an ethics and health policy statement on adult and pediatric DCDD relevant to critical care and transplantation stakeholders. A multidisciplinary panel of stakeholders was convened to develop an ethics and health policy statement. The panel consisted of representatives from the American Thoracic Society, Society of Critical Care Medicine, International Society for Heart and Lung Transplantation, Association of Organ Procurement Organizations, and the United Network of Organ Sharing. The panel reviewed the literature, discussed important ethics and health policy considerations, and developed a guiding framework for decision making by stakeholders. A framework to guide ethics and health policy statement was established, which addressed the consent process, pre- and post mortem interventions, the determination of death, provisions of end-of-life care, and pediatric DCDD. The information presented in this Statement is based on the current evidence, experience, and clinical rationale. New clinical research and the development and dissemination of new technologies will eventually necessitate an update of this Statement.

CU Prime Diversity Workshops: Creating Spaces for Growth Amongst Organizers

NASA Astrophysics Data System (ADS)

Hyater-Adams, Simone

2016-03-01

CU Prime is a graduate student run organization that was created as a way to promote community and inclusion amongst students in CU Physics Department. With a mission to improve the experiences of students, especially those underrepresented in the department and field, the core organizers developed three programs: a seminar series, a class, and a mentorship program. However, because this is strictly volunteer time for most organizers, there is little time for development and growth as a group. In response, we developed a series of diversity workshops for the group, in order to provide space and time for organizers to reflect on and grapple with difficult issues around diversity and inclusion that are important to think about when running these programs. With a structure based on readings, informal videos, and reflection, there have been 5 workshops around topics ranging from gender in physics to how to be an ally. We overview the structure and framing of these workshops, along with the challenges and successes throughout the process of developing them, along with plans for future development.

Developing Organizational Adaptability for Complex Environment

ERIC Educational Resources Information Center

Boylan, Steven A.; Turner, Kenneth A.

2017-01-01

Developing organizations capable of adapting requires leaders to set conditions. Setting conditions normally requires purposeful activities by the leadership to foster and develop leader and individual adaptability, supported by processes and activities that enable adaptive behaviors through the totality of the organization (Goldstein, Hazy, &…

24 CFR 582.100 - Program component descriptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... organizations. A sponsor may be a private, nonprofit organization or a community mental health agency... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES SHELTER PLUS CARE Assistance Provided § 582.100 Program...

Complexities of Organization Dynamics and Development: Leaders and Managers

ERIC Educational Resources Information Center

Nderu-Boddington, Eulalee

2008-01-01

This article shows the theoretical framework for understanding organizational dynamics and development - the change theory and subordinate relationships within contemporary organizations. The emphasis is on power strategies and the relationship to organizational dynamics and development. The integrative process broadens the understanding of…

The Journal of Staff, Program, & Organization Development, Volume 4, Numbers 1-4, 1986.

ERIC Educational Resources Information Center

Watts, Gordon E., Ed.

1986-01-01

These four issues of "The Journal of Staff, Program, and Organization Development" contain the following articles: "A Theory of Effectiveness: Faculty Development Case Studies," by Ronald Smith and Fred Schwartz; "Career Goals of Faculty," by Mary Deane Sorcinelli; "Effects of a Staff Development Center," by Donna Nickel; "Distinguished Teaching…

Using a Personal Development Plan for Different Purposes: Its Influence on Undertaking Learning Activities and Job Performance

ERIC Educational Resources Information Center

Beausaert, Simon A. J.; Segers, Mien S. R.; Gijselaers, Wim H.

2011-01-01

Today, organizations are increasingly implementing assessment tools such as Personal Development Plans. Although the true power of the tool lies in supporting the employee's continuing professional development, organizations implement the tool for various different purposes, professional development purposes on the one hand and promotion/salary…

Developing an OD-Intervention Metric System with the Use of Applied Theory-Building Methodology: A Work/Life-Intervention Example

ERIC Educational Resources Information Center

Morris, Michael Lane; Storberg-Walker, Julia; McMillan, Heather S.

2009-01-01

This article presents a new model, generated through applied theory-building research methods, that helps human resource development (HRD) practitioners evaluate the return on investment (ROI) of organization development (OD) interventions. This model, called organization development human-capital accounting system (ODHCAS), identifies…

Spiritual Development--A Missing and Powerful Leverage When Building Learning Organizations

ERIC Educational Resources Information Center

Rupcic, Nataša

2017-01-01

Purpose: The purpose of this paper is to examine and discuss the role that spiritual development plays in the development of learning individuals and organizations. Spiritual development has been examined though the lens of various meditative practices (such as transcendental meditation, mindfulness and flow) and religious indoctrinations (such as…

Neighborhoods in Development: Human Development Index and Self-Organizing Maps

ERIC Educational Resources Information Center

Rende, Sevinc; Donduran, Murat

2013-01-01

The Human Development Index (HDI) has been instrumental in broadening the discussion of economic development beyond money-metric progress, in particular, by ranking a country against other countries in terms of the well being of their citizens. We propose self-organizing maps to explore similarities among countries using the components of the HDI…

An integrated miRNA functional screening and target validation method for organ morphogenesis.

PubMed

Rebustini, Ivan T; Vlahos, Maryann; Packer, Trevor; Kukuruzinska, Maria A; Maas, Richard L

2016-03-16

The relative ease of identifying microRNAs and their increasing recognition as important regulators of organogenesis motivate the development of methods to efficiently assess microRNA function during organ morphogenesis. In this context, embryonic organ explants provide a reliable and reproducible system that recapitulates some of the important early morphogenetic processes during organ development. Here we present a method to target microRNA function in explanted mouse embryonic organs. Our method combines the use of peptide-based nanoparticles to transfect specific microRNA inhibitors or activators into embryonic organ explants, with a microRNA pulldown assay that allows direct identification of microRNA targets. This method provides effective assessment of microRNA function during organ morphogenesis, allows prioritization of multiple microRNAs in parallel for subsequent genetic approaches, and can be applied to a variety of embryonic organs.

A Novel, Low-Volume Method for Organ Culture of Embryonic Kidneys That Allows Development of Cortico-Medullary Anatomical Organization

PubMed Central

Sebinger, David D. R.; Unbekandt, Mathieu; Ganeva, Veronika V.; Ofenbauer, Andreas; Werner, Carsten; Davies, Jamie A.

2010-01-01

Here, we present a novel method for culturing kidneys in low volumes of medium that offers more organotypic development compared to conventional methods. Organ culture is a powerful technique for studying renal development. It recapitulates many aspects of early development very well, but the established techniques have some disadvantages: in particular, they require relatively large volumes (1–3 mls) of culture medium, which can make high-throughput screens expensive, they require porous (filter) substrates which are difficult to modify chemically, and the organs produced do not achieve good cortico-medullary zonation. Here, we present a technique of growing kidney rudiments in very low volumes of medium–around 85 microliters–using silicone chambers. In this system, kidneys grow directly on glass, grow larger than in conventional culture and develop a clear anatomical cortico-medullary zonation with extended loops of Henle. PMID:20479933

Organization of Physical Activities as a Precondition of Quality Development of Motor Abilities of Pre-School and School Children

ERIC Educational Resources Information Center

Markovic, Živorad; Kopas-Vukašinovic, Emina

2015-01-01

In their work authors consider the significance of the organization of physical activities for the development of abilities of pre-school and school children. Led by theoretical basis that physical development of children represents the basis of their whole development, and that "fine motor skills" are determined by the development of…

A process improvement model for software verification and validation

NASA Technical Reports Server (NTRS)

Callahan, John; Sabolish, George

1994-01-01

We describe ongoing work at the NASA Independent Verification and Validation (IV&V) Facility to establish a process improvement model for software verification and validation (V&V) organizations. This model, similar to those used by some software development organizations, uses measurement-based techniques to identify problem areas and introduce incremental improvements. We seek to replicate this model for organizations involved in V&V on large-scale software development projects such as EOS and space station. At the IV&V Facility, a university research group and V&V contractors are working together to collect metrics across projects in order to determine the effectiveness of V&V and improve its application. Since V&V processes are intimately tied to development processes, this paper also examines the repercussions for development organizations in large-scale efforts.

A process improvement model for software verification and validation

NASA Technical Reports Server (NTRS)

Callahan, John; Sabolish, George

1994-01-01

We describe ongoing work at the NASA Independent Verification and Validation (IV&V) Facility to establish a process improvement model for software verification and validation (V&V) organizations. This model, similar to those used by some software development organizations, uses measurement-based techniques to identify problem areas and introduce incremental improvements. We seek to replicate this model for organizations involved in V&V on large-scale software development projects such as EOS and Space Station. At the IV&V Facility, a university research group and V&V contractors are working together to collect metrics across projects in order to determine the effectiveness of V&V and improve its application. Since V&V processes are intimately tied to development processes, this paper also examines the repercussions for development organizations in large-scale efforts.

Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography

NASA Astrophysics Data System (ADS)

Burton, Jason C.; Wang, Shang; Behringer, Richard R.; Larina, Irina V.

2016-03-01

Infertility is a known major health concern and is estimated to impact ~15% of couples in the U.S. The majority of failed pregnancies occur before or during implantation of the fertilized embryo into the uterus. Understanding the mechanisms regulating development by studying mouse reproductive organs could significantly contribute to an improved understanding of normal development of reproductive organs and developmental causes of infertility in humans. Towards this goal, we report a three-dimensional (3D) imaging study of the developing mouse reproductive organs (ovary, oviduct, and uterus) using optical coherence tomography (OCT). In our study, OCT was used for 3D imaging of reproductive organs without exogenous contrast agents and provides micro-scale spatial resolution. Experiments were conducted in vitro on mouse reproductive organs ranging from the embryonic day 14.5 to adult stages. Structural features of the ovary, oviduct, and uterus are presented. Additionally, a comparison with traditional histological analysis is illustrated. These results provide a basis for a wide range of infertility studies in mouse models. Through integration with traditional genetic and molecular biology approaches, this imaging method can improve understanding of ovary, oviduct, and uterus development and function, serving to further contribute to our understanding of fertility and infertility.

Polymeric membrane materials for artificial organs.

PubMed

Kawakami, Hiroyoshi

2008-01-01

Many polymeric materials have already been used in the field of artificial organs. However, the materials used in artificial organs are not necessarily created with the best material selectivity and materials design; therefore, the development of synthesized polymeric membrane materials for artificial organs based on well-defined designs is required. The approaches to the development of biocompatible polymeric materials fall into three categories: (1) control of physicochemical characteristics on material surfaces, (2) modification of material surfaces using biomolecules, and (3) construction of biomimetic membrane surfaces. This review will describe current issues regarding polymeric membrane materials for use in artificial organs.

The Body Game: Developed by Undergraduates for Key Stage 2 National Curriculum Science.

ERIC Educational Resources Information Center

Verran, J.; Brintnell, B.; Brownrigg, N.; Garcia, R.; Green, A.

1997-01-01

Describes a game developed for school children which addresses part of the Science National Curriculum. The board is a human body with organs on view. Questions relate to different organ systems, body parts, and processes. Topics include breathing, digestion and metabolism, blood and circulation, and the sensory organs and teeth. (AIM)

25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

Code of Federal Regulations, 2010 CFR

2010-04-01

...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

Code of Federal Regulations, 2011 CFR

2011-04-01

...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

Code of Federal Regulations, 2014 CFR

2014-04-01

...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

Code of Federal Regulations, 2013 CFR

2013-04-01

...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

Perry's Scheme of Intellectual and Epistemological Development as a Framework for Describing Student Difficulties in Learning Organic Chemistry

ERIC Educational Resources Information Center

Grove, Nathaniel P.; Bretz, Stacey Lowery

2010-01-01

We have investigated student difficulties with the learning of organic chemistry. Using Perry's Model of Intellectual Development as a framework revealed that organic chemistry students who function as dualistic thinkers struggle with the complexity of the subject matter. Understanding substitution/elimination reactions and multi-step syntheses is…

Employees' Organizations and Their Contribution to the Development of Vocational Training Policy in the European Community.

ERIC Educational Resources Information Center

Lemke, Horst

This document includes eight chapters and an appendix that lists abbreviations and trade union organizations at the European Community (EC) level. Chapter 1 identifies the roles of employers, employee organizations or trade unions, and system conditions in the development of vocational training policies in the European community. Chapter 2…

The Significance of Student Organizations to Leadership Development.

PubMed

Rosch, David M; Collins, Jasmine D

2017-09-01

Student organizations have existed for almost as long as educational institutions have. This chapter examines the historical role of student organizations in developing leadership capacity in students, as well as their current roles on high school and collegiate campuses in creating transformational environments for student leadership learning and growth. © 2017 Wiley Periodicals, Inc., A Wiley Company.

Emerging Developments in the Study of Organizations. ASHE Annual Meeting 1982 Paper.

ERIC Educational Resources Information Center

March, James G.

Development in the study of organizations and needs for additional research are addressed. It is suggested that when goals are not achieved, an organization searches for new alternatives and new information. When aspirations are achieved, the search for new alternatives is assumed to be modest, slack accumulates, and aspirations rise. It has been…

Soil organic phosphorus characterisation on a glacial chronosequence (Damma, Switzerland)

NASA Astrophysics Data System (ADS)

Jarosch, Klaus A.; Requejo, María I.; Bünemann, Else K.

2015-04-01

Soil organic phosphorus (P) may play a significant role in ecosystem P dynamics, yet, little is known about the development of different organic P classes over time. According to the commonly accepted model, relative proportions of organic P are expected to increase quickly after the commencement of soil development, subsequently remaining relatively stable over time. We tested this hypothesis on a young soil chronosequence in the Damma glacier forefield (Switzerland), where we examined the development of different organic P classes over time. In detail, we hypothesized that organic P compounds resistant against broadly active phosphatase-enzymes would increase with soil age. Soil samples (0-5 cm) were taken on 21 sites with 6 to 136 years of soil development. Using enzyme addition assays to soil extracts (0.25 M NaOH / 0.05 M EDTA), four organic P classes were detected: a) Monoester-like P (organic P hydrolysed by an acid phosphatase), b) DNA-like P (organic P hydrolysed by a nuclease in combination with an acid phosphatase, minus monoester-like P), c) Inositol Phosphate-like P (organic P hydrolysed by a phytase, minus monoester like P) and d) Enzyme stable P (difference between total extracted organic P and the three enzyme labile P classes a, b and c). NaOH-EDTA extractable inorganic and organic P increased with soil age from 4.2 and 5.2 mg kg-1 at the youngest sites to 23.9 and 64.5 mg kg-1 at the oldest sites, respectively. On all sites, more organic than inorganic P was extracted. We observed a strong linear relationship between organic and inorganic P along the chronosequence. Between 60 and 100% of extractable organic P was hydrolysed by the added enzymes, without a clear trend with respect to soil age. On most sites, Inositol phosphate-like P was the most prominent organic P class (1.8-24.3 mg kg-1). However, on some sites higher amounts of monoester-like P were detected (0.4-23.4 mg kg-1). DNA-like P ranged from nil to 12.9 mg kg-1. Thus, we observed a significant increase in all forms of organic P with increasing soil age, except enzyme-stable P which fluctuated across the chronosequence. The results will be interpreted in relation to published data on microbial and plant community composition. Keywords: Soil organic phosphorus, Damma chronosequence, Enzyme addition assays

Environment, Environmental Restoration, and Waste Management Field Organization Directory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-07-01

This directory was developed by the Office of Environmental Guidance, RCRA/CERCLA Division (EH-231) from an outgrowth of the Departments efforts to identify and establish the regulatory response lead persons in the Field Organizations. The directory was developed for intemal EH-231 use to identify both the DOE and DOE contractor Field Organizations in the Environment, Environmental Restoration and Waste Management areas. The Field Organization directory is divided into three substantive sections: (1) Environment; (2) Environmental Restoration; and (3) Waste Management which are organized to correspond to the management hierarchy at each Field Organization. The information provided includes the facility name andmore » address, individual managers name, and telephone/fax numbers.« less

Modeling forest development after fire disturbance: Climate, soil organic layer, and nitrogen jointly affect forest canopy species and long-term ecosystem carbon accumulation in the North American boreal forest

NASA Astrophysics Data System (ADS)

Trugman, A. T.; Fenton, N.; Bergeron, Y.; Xu, X.; Welp, L.; Medvigy, D.

2015-12-01

Soil organic layer dynamics strongly affect boreal forest development after fire. Field studies show that soil organic layer thickness exerts a species-specific control on propagule establishment in the North American boreal forest. On organic soils thicker than a few centimeters, all propagules are less able to recruit, but broadleaf trees recruit less effectively than needleleaf trees. In turn, forest growth controls organic layer accumulation through modulating litter input and litter quality. These dynamics have not been fully incorporated into models, but may be essential for accurate projections of ecosystem carbon storage. Here, we develop a data-constrained model for understanding boreal forest development after fire. We update the ED2 model to include new aspen and black spruce species-types, species-specific propagule survivorship dependent on soil organic layer depth, species-specific litter decay rates, dynamically accumulating moss and soil organic layers, and nitrogen fixation by cyanobacteria associated with moss. The model is validated against diverse observations ranging from monthly to centennial timescales and spanning a climate gradient in Alaska, central Canada, and Quebec. We then quantify differences in forest development that result from changes in organic layer accumulation, temperature, and nitrogen. We find that (1) the model accurately reproduces a range of observations throughout the North American boreal forest; (2) the presence of a thick organic layer results in decreased decomposition and decreased aboveground productivity, effects that can increase or decrease ecosystem carbon uptake depending on location-specific attributes; (3) with a mean warming of 4°C, some forests switch from undergoing succession to needleleaf forests to recruiting multiple cohorts of broadleaf trees, decreasing ecosystem accumulation by ~30% after 300 years; (4) the availability of nitrogen regulates successional dynamics such than broadleaf species are less able to compete with needleleaf trees under low nitrogen regimes. We conclude that a joint regulation between the soil organic layer, temperature, and nitrogen will likely play an important role in influencing boreal forests development after fire in future climates, and should be represented in models.

Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas[OPEN

PubMed Central

Montenegro-Johnson, Thomas D.; Stamm, Petra; Strauss, Soeren; Topham, Alexander T.; Tsagris, Michail; Wood, Andrew T.A.; Smith, Richard S.; Bassel, George W.

2015-01-01

Diverse molecular networks underlying plant growth and development are rapidly being uncovered. Integrating these data into the spatial and temporal context of dynamic organ growth remains a technical challenge. We developed 3DCellAtlas, an integrative computational pipeline that semiautomatically identifies cell types and quantifies both 3D cellular anisotropy and reporter abundance at single-cell resolution across whole plant organs. Cell identification is no less than 97.8% accurate and does not require transgenic lineage markers or reference atlases. Cell positions within organs are defined using an internal indexing system generating cellular level organ atlases where data from multiple samples can be integrated. Using this approach, we quantified the organ-wide cell-type-specific 3D cellular anisotropy driving Arabidopsis thaliana hypocotyl elongation. The impact ethylene has on hypocotyl 3D cell anisotropy identified the preferential growth of endodermis in response to this hormone. The spatiotemporal dynamics of the endogenous DELLA protein RGA, expansin gene EXPA3, and cell expansion was quantified within distinct cell types of Arabidopsis roots. A significant regulatory relationship between RGA, EXPA3, and growth was present in the epidermis and endodermis. The use of single-cell analyses of plant development enables the dynamics of diverse regulatory networks to be integrated with 3D organ growth. PMID:25901089

Training for Agriculture and Rural Development--1975.

ERIC Educational Resources Information Center

United Nations Food and Agriculture Organization, Rome (Italy).

Eighteen papers about education, training, and extension in rural areas of the developing world are presented in this 1975 journal published jointly by three United Nations agencies closely concerned with education and rural development: Food and Agriculture Organization; Education, Scientific, and Cultural Organization; International Labor…

MASTER ANALYTICAL SCHEME FOR ORGANIC COMPOUNDS IN WATER: PART 1. PROTOCOLS

EPA Science Inventory

A Master Analytical Scheme (MAS) has been developed for the analysis of volatile (gas chromatographable) organic compounds in water. In developing the MAS, it was necessary to evaluate and modify existing analysis procedures and develop new techniques to produce protocols that pr...

Developing a Simulated-Person Methodology Workshop: An Experiential Education Initiative for Educators and Simulators

ERIC Educational Resources Information Center

Peisachovich, Eva Hava; Nelles, L. J.; Johnson, Samantha; Nicholson, Laura; Gal, Raya; Kerr, Barbara; Celia, Popovic; Epstein, Iris; Da Silva, Celina

2017-01-01

Numerous forecasts suggest that professional-competence development depends on human encounters. Interaction between organizations, tasks, and individual providers influence human behaviour, affect organizations' or systems' performance, and are a key component of professional-competence development. Further, insufficient or ineffective…

Phase 2 STS new user development program. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Mcdowell, J. R.

1976-01-01

A methodology for developing new users for STS other than NASA and DoD, thereby maximizing the use of the STS system was developed. The approach to user development, reflected in the implementation plan, and attendant informational material to be used were evaluated by conducting a series of test cases with selected user organizations. These test case organizations were, in effect, used as consultants to evaluate the effectiveness, the needs, the completeness, and the adequacy of the user development approach and informational material. The selection of the test cases provided a variety of potential STS users covering industry, other government agencies, and the educational sector. The test cases covered various use areas and provided a mix of user organization types. A summary of the actual test cases conducted is given. The conduct of the test cases verified the general approach of the implementation plan, the validity of the user development strategy prepared for each test case organization and the effectiveness of the STS basic and user customized informational material.

Domain analysis for the reuse of software development experiences

NASA Technical Reports Server (NTRS)

Basili, V. R.; Briand, L. C.; Thomas, W. M.

1994-01-01

We need to be able to learn from past experiences so we can improve our software processes and products. The Experience Factory is an organizational structure designed to support and encourage the effective reuse of software experiences. This structure consists of two organizations which separates project development concerns from organizational concerns of experience packaging and learning. The experience factory provides the processes and support for analyzing, packaging, and improving the organization's stored experience. The project organization is structured to reuse this stored experience in its development efforts. However, a number of questions arise: What past experiences are relevant? Can they all be used (reused) on our current project? How do we take advantage of what has been learned in other parts of the organization? How do we take advantage of experience in the world-at-large? Can someone else's best practices be used in our organization with confidence? This paper describes approaches to help answer these questions. We propose both quantitative and qualitative approaches for effectively reusing software development experiences.

Organizer formation in Hydra is disrupted by thalidomide treatment.

PubMed

Brooun, Maria; Manoukian, Armen; Shimizu, Hiroshi; Bode, Hans R; McNeill, Helen

2013-06-01

Thalidomide is a drug that is well known for its teratogenic properties in humans. Surprisingly, thalidomide does not have teratogenic effects on mouse development. We investigated the effect of thalidomide on patterning in hydra, an early metazoan with a very simple axial symmetry. Hydra develops asexually via Wnt-dependent organizer formation, leading to the budding of a new organism. We observe both induction and inhibition of organizer formation depending on cellular context. Interestingly, thalidomide treatment altered budding and the developing organizer, but had little effect on the adult. Expression of Hybra1, a marker of the organizer increased upon thalidomide treatment. However when the organizer is induced by ectopic activation of Wnt signaling via GSK3 inhibition, thalidomide suppresses induction. We show that inhibition of Wnt signaling is not mediated by induction of the BMP pathway. We show that thalidomide activity on organizer formation in hydra depends on the activity of casein kinase1 and the abundance of β-catenin. Finally, we find that interstitial cells, multipotent cells which give rise to nemoatocytes, neural, digestive and germline cells, are partially responsible for the inhibitory effect of thalidomide. Copyright © 2013 Elsevier Inc. All rights reserved.

The tyranny of taste: the case of organic rice in Cambodia.

PubMed

Thavat, Maylee

2011-01-01

Fair-trade and organic products are often sold at price premiums justified by smaller production volumes that are associated with greater social and environmental responsibility. The consumption of these products confers on the consumer a greater sense of morality – and usually a claim to better taste. This paper tells the story of attempts to promote organic/fair-trade rice production by de facto organic Cambodian farmers for export to North American and European markets in order to assist poor farmers to trade their way out of poverty. It demonstrates that instead of promoting sustainable agriculture and fair trade between developed and developing markets, organic/fair-trade projects may impose First World consumer ideals and tastes that are out of step with the larger realities of agrarian transition in Cambodia and the wider region of developing Southeast Asia.

Capacity Building as a Tool for Assessing Training and Development Activity: An Indian Case Study

ERIC Educational Resources Information Center

Krishnaveni, R.; Sripirabaa, B.

2008-01-01

In recognition of its increasing importance, many organizations make periodic assessments of their training and development activity. The objective of the present study was to extend the concept of capacity building to the assessment of training and development activity in an automobile component manufacturing organization, using a developed and…

Youth Leadership Development: A National Analysis of FFA Member Role and Activity Context

ERIC Educational Resources Information Center

Peiter Horstmeier, Robin; Nall, Martha A.

2007-01-01

A purpose of youth organizations is to develop leadership skills among members through organizational structure and organization sponsored activities. But do they develop those skills? This national, multi-stage study examined the role of youth and the context of their activities in developing leadership in rural FFA chapters. FFA members had a…

Organization Development: A Critique

ERIC Educational Resources Information Center

Stephenson, T. E.

1975-01-01

Reviews the literature dealing with organization development (OD) and discusses the predominant concerns and attitudes of OD theorists and practitioners. Suggests that OD might be more aptly named "human development" and argues that OD practitioners generally act as missionaries who feel they must remedy the errors of their clients' behavior. (JG)

MASTER ANALYTICAL SCHEME FOR ORGANIC COMPOUNDS IN WATER. PART 2. APPENDICES TO PROTOCOLS

EPA Science Inventory

A Master Analytical Scheme (MAS) has been developed for the analysis of volatile (gas chromatographable) organic compounds in water. In developing the MAS, it was necessary to evaluate and modify existing analysis procedures and develop new techniques to produce protocols that pr...

Developing Natural Solutions to Reducing Food Safety Pathogens in Organically Raised Poultry

USDA-ARS?s Scientific Manuscript database

Organic poultry production is one of the fastest growing segments of organic agriculture with a 20% increase/yr since the establishment of the National Organic Program (NOP). Restrictions on prophylactic antibiotics used for conventional poultry production raise unique challenges for organic produce...

The Development of Organized Rehearsal

ERIC Educational Resources Information Center

Weist, Richard M.; Crawford, Jack

1977-01-01

In a study of development of organization strategies in rehearsal processes, children in the first, third, and fifth grades were exposed to a memory task which involved multiple overt rehearsal and recall phases. (SB)

Development and Psychometric Evaluation of the Instrument: Attitudes Towards Organ Donor Advocacy Scale (ATODAS)

PubMed Central

Flodén, Anne; Lennerling, Annette; Fridh, Isabell; Rizell, Magnus; Forsberg, Anna

2011-01-01

The consequences of advocacy in nursing are critical when caring for a potential organ donor. No specific instrument has been available to measure attitudes toward organ donor advocacy. The aim of this study was to develop and psychometrically evaluate an instrument for measuring intensive and critical care (ICU) nurses’ attitudes toward organ donor advocacy. The study was conducted in two stages: instrument development and instrument evaluation and refinement. A questionnaire was developed (Attitude Toward Organ Donor Advocacy Scale (ATODAS)), which was sent to half of all nurses working in ICUs (general-, neuro-, thoracic- or paediatric-) in Sweden (n=1180). The final response rate was 42.5% (n=502). In order to explore validity and reliability, the expected scale dimensionality of the questionnaire was examined both by explorative principal component analysis (with oblique, varimax rotation) and by confirmatory multi-trait analysis. The confirmatory factor analysis indicated that the ATODAS could best be explained by five factors; Attitudes toward championing organ donation at a structural hospital level; Attitudes toward championing organ donation at a political and research level; Attitudes toward actively and personally safeguarding the will and wishes of the potential organ donor, Attitudes toward safeguarding the potential donor’s will and wishes by a professional approach and Attitudes toward safeguarding the will and wishes of the relatives. This initial testing indicated that the ATODAS has good psychometric properties and can be used in future research to explore if interventions may influence attitudes and behaviors related to organ donor advocacy. PMID:22046210

Coordination-supported organic polymers: mesoporous inorganic–organic materials with preferred stability

DOE PAGES

Chen, Dong; Zhang, Pengfei; Fang, Qianrong; ...

2018-01-01

A simple and versatile strategy is developed for the synthesis of coordination-supported organic polymers(COPs) via coordination between Al 3+ and 5-amino-8-hydroxyquinoline together with organic imine- or imide-based polycondensation.

DEHYDRATION OF LOW WATER CONTENT ETHANOL

EPA Science Inventory

Pervaporation has emerged as an economically viable alternative technology for the dehydration of organic solvents, removal of organic compounds from water and organic/organic separations. Development of a membrane system with suitable flux and selectivity characteristics plays a...

Coordination-supported organic polymers: mesoporous inorganic–organic materials with preferred stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Dong; Zhang, Pengfei; Fang, Qianrong

A simple and versatile strategy is developed for the synthesis of coordination-supported organic polymers(COPs) via coordination between Al 3+ and 5-amino-8-hydroxyquinoline together with organic imine- or imide-based polycondensation.

Hypothermic temperature effects on organ survival and restoration

PubMed Central

Ishikawa, Jun; Oshima, Masamitsu; Iwasaki, Fumitaka; Suzuki, Ryoji; Park, Joonhong; Nakao, Kazuhisa; Matsuzawa-Adachi, Yuki; Mizutsuki, Taro; Kobayashi, Ayaka; Abe, Yuta; Kobayashi, Eiji; Tezuka, Katsunari; Tsuji, Takashi

2015-01-01

A three-dimensional multicellular organism maintains the biological functions of life support by using the blood circulation to transport oxygen and nutrients and to regulate body temperature for intracellular enzymatic reactions. Donor organ transplantation using low-temperature storage is used as the fundamental treatment for dysfunctional organs. However, this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage. In this study, we developed a novel liver perfusion culture system based on biological metabolism that can maintain physiological functions, including albumin synthesis, bile secretion and urea production. This system also allows for the resurrection of a severely ischaemic liver. This study represents a significant advance for the development of an ex vivo organ perfusion system based on biological metabolism. It can be used not only to address donor organ shortages but also as the basis of future regenerative organ replacement therapy. PMID:25900715

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems.

PubMed

Zheng, Fuyin; Fu, Fanfan; Cheng, Yao; Wang, Chunyan; Zhao, Yuanjin; Gu, Zhongze

2016-05-01

"Organ-on-a-chip" systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell-cell interactions, and extracellular microenvironments. This creative platform and its multiorgan integration recapitulating organ-level structures and functions can bring unprecedented benefits to a diversity of applications, such as developing human in vitro models for healthy or diseased organs, enabling the investigation of fundamental mechanisms in disease etiology and organogenesis, benefiting drug development in toxicity screening and target discovery, and potentially serving as replacements for animal testing. Recent advances in novel designs and examples for developing organ-on-a-chip platforms are reviewed. The potential for using this emerging technology in understanding human physiology including mechanical, chemical, and electrical signals with precise spatiotemporal controls are discussed. The current challenges and future directions that need to be pursued for these proof-of-concept studies are also be highlighted. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Taking stock of youth organizing: an interdisciplinary perspective.

PubMed

Christens, Brian D; Kirshner, Ben

2011-01-01

Youth organizing combines elements of community organizing, with its emphasis on ordinary people working collectively to advance shared interests, and positive youth development, with its emphasis on asset-based approaches to working with young people. It is expanding from an innovative, but marginal approach to youth and community development into a more widely recognized model for practice among nonprofit organizations and foundations. Along the way, it has garnered attention from researchers interested in civic engagement, social movements, and resiliency. A growing body of published work evidences the increasing interest of researchers, who have applied an assortment of theoretical perspectives to their observations of youth organizing processes. Through an appraisal of the current state of this still-emerging area of practice and research, including case examples, the authors identify common elements of the practice of youth organizing--relationship development, popular education, social action, and participatory research and evaluation--and conclude with a discussion of promising future directions for research and practice. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.

Cancer of the head and neck region in solid organ transplant recipients.

PubMed

Rabinovics, Naomi; Mizrachi, Aviram; Hadar, Tuvia; Ad-El, Dean; Feinmesser, Raphael; Guttman, Dan; Shpitzer, Thomas; Bachar, Gideon

2014-02-01

Solid organ recipients are at an increased risk of developing various malignancies. We investigated the incidence, clinical features, and outcome of patients diagnosed with head and neck cancer after organ transplantation. A retrospective analysis was undertaken of patients who underwent solid organ transplantation (kidney, liver, lung, heart) treated at our institution from 1992 to 2010. Of 2817 organ recipients, 175 patients (6.1%) developed 391 head and neck malignancies. Cutaneous malignancies were the most common (93%): squamous cell carcinoma (SCC; 51%) and basal cell carcinoma (BCC; 42%). The average interval from transplantation to diagnosis of head and neck malignancy was 7.3 years, with liver recipients diagnosed earlier. Eighteen percent of patients presented with an aggressive pattern of head and neck cancer, including 24% of patients with cutaneous SCC. Organ transplantation recipients are at a higher risk to develop head and neck cancer with an aggressive behavior characterized by multiple recurrences and decreased survival. Copyright © 2013 Wiley Periodicals, Inc.

The quest for restoring hearing: Understanding ear development more completely.

PubMed

Jahan, Israt; Pan, Ning; Elliott, Karen L; Fritzsch, Bernd

2015-09-01

Neurosensory hearing loss is a growing problem of super-aged societies. Cochlear implants can restore some hearing, but rebuilding a lost hearing organ would be superior. Research has discovered many cellular and molecular steps to develop a hearing organ but translating those insights into hearing organ restoration remains unclear. For example, we cannot make various hair cell types and arrange them into their specific patterns surrounded by the right type of supporting cells in the right numbers. Our overview of the topologically highly organized and functionally diversified cellular mosaic of the mammalian hearing organ highlights what is known and unknown about its development. Following this analysis, we suggest critical steps to guide future attempts toward restoration of a functional organ of Corti. We argue that generating mutant mouse lines that mimic human pathology to fine-tune attempts toward long-term functional restoration are needed to go beyond the hope generated by restoring single hair cells in postnatal sensory epithelia. © 2015 WILEY Periodicals, Inc.

The Uses and Consequences of Literacy in the Daily Lives of Ordinary People: From an Evaluation of Adult Literacy Organization of Zimbabwe (ALOZ).

ERIC Educational Resources Information Center

Bhola, H. S.

To evaluate the Adult Literacy Organization of Zimbabwe (ALOZ), an organization whose aim is to achieve universal literacy in Zimbabwe, a study interviewed officials at ALOZ, the United States Agency for International Development (USAID), and other institutions involved in literacy development; reviewed relevant literature and documents;…

Non-Profit Education Providers vis-a-vis the Private Sector: Comparative Analysis of Non-Governmental Organizations and Traditional Voluntary Organizations in Pakistan

ERIC Educational Resources Information Center

Bano, Masooda

2008-01-01

Under the New Policy Agenda, international development institutions have promoted non-profit organizations (NPOs) in developing countries, on a dual logic: firstly, they deliver social services more efficiently than the state; secondly, they mitigate equity concerns around privatization of basic social services by reaching out to the poor. Based…

People's Participation in Development and the Management of Natural Resources. Report on the Caribbean Regional Workshop (Vieux Fort, St. Lucia, April 15-19, 1985).

ERIC Educational Resources Information Center

Vukasin, Helen L., Ed.

This Caribbean Regional Workshop was organized to bring together representatives of private, voluntary, and community development organizations, governmental agencies, and other non-governmental organizations in the Eastern Caribbean who were concerned with environmental quality. The conference was intended to improve the level of citizen…

Organic and Hybrid Organic Solid-State Photovoltaic Materials and Devices

DTIC Science & Technology

2014-02-19

hybrids have potential applications in solar cells and may thus provide mobile energy sources for aircraft and soldier technologies. Modeling and...modeling and simulation developed in this project are encouraging further development. 2. Technical Activities Hybrid organic solar cells are an...between surface-modified semiconducting nanoparticles and polymers often contributes to the limited efficiency of hybrid photovoltaic cells and

Designing Undergraduate-Level Organic Chemistry Instructional Problems: Seven Ideas from a Problem-Solving Study of Practicing Synthetic Organic Chemists

ERIC Educational Resources Information Center

Raker, Jeffrey R.; Towns, Marcy H.

2012-01-01

The development of curricular problems based on the practice of synthetic organic chemistry has not been explored in the literature. Such problems have broadly been hypothesized to promote student persistence and interest in STEM fields. This study reports seven ideas about how practice-based problems can be developed for sophomore-level organic…

Development of efficiency module of organization of Arctic sea cargo transportation with application of neural network technologies

NASA Astrophysics Data System (ADS)

Sobolevskaya, E. Yu; Glushkov, S. V.; Levchenko, N. G.; Orlov, A. P.

2018-05-01

The analysis of software intended for organizing and managing the processes of sea cargo transportation has been carried out. The shortcomings of information resources are presented, for the organization of work in the Arctic and Subarctic regions of the Far East: the lack of decision support systems, the lack of factor analysis to calculate the time and cost of delivery. The architecture of the module for calculating the effectiveness of the organization of sea cargo transportation has been developed. The simulation process has been considered, which is based on the neural network. The main classification factors with their weighting coefficients have been identified. The architecture of the neural network has been developed to calculate the efficiency of the organization of sea cargo transportation in Arctic conditions. The architecture of the intellectual system of organization of sea cargo transportation has been developed, taking into account the difficult navigation conditions in the Arctic. Its implementation will allow one to provide the management of the shipping company with predictive analytics; to support decision-making; to calculate the most efficient delivery route; to provide on demand online transportation forecast, to minimize the shipping cost, delays in transit, and risks to cargo safety.

Development Index, A Proposed Pattern for Organizing and Facilitating the Flow of Information Needed By Man in Furthering His Own Development, With Particular Reference to the Development of Buildings and Communities and Other Forms of Environmental Control.

ERIC Educational Resources Information Center

Michigan Univ., Ann Arbor.

The organization of knowledge related to the development of the environment and the building industry is provided in this index which provides a framework or classification system for a broad range of information. Man's development in terms of environmental structuring and control is discussed as development goals, development cycle, and…

Bioeconomy Initiative at MBI International

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kleff, Susanne, Ph.D.

Di-carboxylic acids have the potential to replace petrochemicals used in the polymer industry (Werpy and Petersen, 2004). MBI developed a process for the production of succinic acid using a proprietary organism. During this work MBI assessed the feasibility to produce other carboxylic acids either using A. succinogenes or other organisms. The development of recombinant A. succinogenes strain derivatives for a mono-carboxylic acid through over-expression of enzymatic activities was successful. Fermentations achieved titers of 58 g/L for this organic acid. Recombinant strains that produced the same acid, but a different stereoisomer, reached titers of 10 g/L. Attempts to increase the titersmore » for this isomer as well as other organic acids were unsuccessful. MBI is looking for commercial partners to pursue the development of recombinant A. succinogenes strains for the production of other organic acids. Attempts to develop recombinant strains of A. succinogenes for fumaric acid production through introduction of various antisense RNA constructs were unsuccessful. Alternative suitable organisms were evaluated and Rhizopus oryzae, a natural fumaric acid producer with potential for process improvements, was selected. A novel fermentation and one-step recovery process was developed that allowed capture of IP, produced titers of >80 g/L with a productivity of 1.8 g/L-h and 57% (g/g glucose) yield. The process was scaled to 2000 L pilot scale. The economic analysis projected a production cost of 72 c/lb. Recycling and re-use of the base was demonstrated and incorporated into the process. The ability of the organism to produce fumaric acid from other carbon sources and biomass hydrolysate was demonstrated. The production of other organic acids was evaluated and techno-economic de-risking roadmap documents were prepared.« less

Freight and air quality handbook

DOT National Transportation Integrated Search

2010-05-01

This handbook was developed as a resource for states, metropolitan planning organizations (MPO), the : Federal Highway Administration (FHWA) and other public- and private-sector organizations to use in : developing solutions to freight related air qu...

EPA's Role with the Organization for Economic Cooperation and Development (OECD)

EPA Pesticide Factsheets

The Organization for Economic Cooperation and Development (OECD) brings together the governments of countries committed to democracy and the market economy from around the world to support sustainable economic growth.

International Perspectives on Youth Leadership Development Through Community Organizing.

PubMed

Govan, Rashida H; Fernandez, Jesica Siham; Lewis, Deana G; Kirshner, Ben

2015-01-01

This chapter details the ways youth community organizing strategies can inform leadership educators' approaches to engaging marginalized youth in leadership development for social change. © 2015 Wiley Periodicals, Inc., A Wiley Company.

77 FR 7594 - Statement of Organization, Functions and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... Organization, Functions and Delegations of Authority This notice amends Part R of the Statement of Organization... RA5--Office of Planning, Analysis and Evaluation Section RA5-10, Organization Delete in its entirety... with HRSA organizations in developing strategic plans for their component; (4) coordinates the Agency's...

The End of Bureaucracy & the Rise of the Intelligent Organization. First Edition.

ERIC Educational Resources Information Center

Pinchot, Gifford; Pinchot, Elizabeth

This book argues that bureaucracy is inappropriate to the information age. It advocates replacing bureaucratic organization with the concept of the "intelligent organization," an organization that develops and engages the intelligence, business judgment, and responsibility of all its members. The successful organization of today builds freedom and…

APPRECIATIVE INQUIRY IN THE OFFICE OF RESEARCH AND DEVELOPMENT: IMPROVING THE COLLABRATIVE CAPACITY OF ORGANIZATION

EPA Science Inventory

This paper highlights the use of appreciative inquiry (AI), a growing practice in organization development in the Office of Research and Development (ORD) of the Environmental Protection Agency. AI is a strength-based approach to change that induces innovation and collaboration t...

Who Should Develop Instructional Materials for CAI?

ERIC Educational Resources Information Center

Seidel, Robert J.

The nonprofit special organization as a developer of computer-administered instruction (CAI) is advocated in this paper. The organization of universities and their mode of operation do not lend themselves to instructional product development. Faculty members engage in such efforts on a part-time basis and in competition with higher priority…

The Effectiveness of International Development Assistance from American Organizations to Deaf Communities in Jamaica

ERIC Educational Resources Information Center

Wilson, A. T.

2005-01-01

American Organizations bringing assistance to deaf people in developing countries unintentionally create relationships of dependency or oppression rather than relationships of support. Using qualitative methods, the author examined the effectiveness of development assistance provided to the Jamaican Deaf community by two American churches, one…

Education and Development. National Reports on the Theme for 1980.

ERIC Educational Resources Information Center

World Confederation of Organizations of the Teaching Profession, Morges (Switzerland).

This collation of national reports pertains to the theme "Education and Development." Thirty-nine member organizations of the World Confederation of Organizations of the Teaching Profession (WCOTP) responded to an inquiry into participating countries' policies, practices, and ideas concerning education as a factor in development, education about…

Consciousness Development for the Learning Organization

ERIC Educational Resources Information Center

Heaton, Dennis

2017-01-01

Purpose: This paper presents a philosophical and practical discussion of the role of development of consciousness for realization of a learning organization. Consciousness is the capacity to know, the capacity to learn. As the knower is, so is the knowledge. Development of consciousness can lead to more profound and holistic learning and enable…

New Horizons Tanzania, Ltd.--A Case of International HRD in Two Parts (Part One)

ERIC Educational Resources Information Center

Williams, Sandra L.; Hurley, Mark N.

2017-01-01

For international organizations in developing countries, operating across cultures can elicit varied perspectives on employee engagement and employee development. Performance pressure from a board of directors will also influence the human resource development emphasis of organization leaders. Varied perspectives and performance pressures place…

Progress in Organization Development Research.

ERIC Educational Resources Information Center

Roberts, Nancy C.; Porras, Jerry I.

1982-01-01

Describes major areas of progress in organization development (OD): progress in operationalizing the concept of change; progress in improving measurement; and progress in designing statistical procedures used to analyze OD intervention data. Suggests recent research developments point to a more solid base on which to build OD practice and theory.…

A Holistic Equilibrium Theory of Organization Development

ERIC Educational Resources Information Center

Yang, Baiyin; Zheng, Wei

2005-01-01

This paper proposes a holistic equilibrium theory of organizational development (OD). The theory states that there are three driving forces in organizational change and development--rationality, reality, and liberty. OD can be viewed as a planned process of change in an organization so as to establish equilibrium among these three interacting…

New Thinking in School Chemistry.

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France).

This report contains the text of addresses given at a seminar on the status and development of the teaching of secondary school chemistry held in 1960 by the Organization for European Economic Development (now the Organization for Economic Cooperation and Development). The speakers considered advances in theoretical chemistry since 1900, the…

Understanding Acceptance of Software Metrics--A Developer Perspective

ERIC Educational Resources Information Center

Umarji, Medha

2009-01-01

Software metrics are measures of software products and processes. Metrics are widely used by software organizations to help manage projects, improve product quality and increase efficiency of the software development process. However, metrics programs tend to have a high failure rate in organizations, and developer pushback is one of the sources…

Mapping a New Field: Cross-Border Professional Development for Teachers

ERIC Educational Resources Information Center

Johnson, Janelle M.

2011-01-01

Many of the international, supranational, national, and grassroots development organizations working in the field of education channel their efforts into capacity-building for teachers. My research examines the nexus of such international development by US-based organizations with national schooling systems by naming and theorizing this process as…

Manipulating Light with Transition Metal Clusters, Organic Dyes, and Metal Organic Frameworks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ogut, Serdar

The primary goals of our research program is to develop and apply state-of-the-art first-principles methods to predict electronic and optical properties of three systems of significant scientific and technological interest: transition metal clusters, organic dyes, and metal-organic frameworks. These systems offer great opportunities to manipulate light for a wide ranging list of energy-related scientific problems and applications. During this grant period, we focused our investigations on the development, implementation, and benchmarking of many-body Green’s function methods (GW approximation and the Bethe-Salpeter equation) to examine excited-state properties of transition metal/transition-metal-oxide clusters and organic molecules that comprise the building blocks of dyesmore » and metal-organic frameworks.« less

Programmed cell death in trypanosomatids and other unicellular organisms.

PubMed

Debrabant, Alain; Lee, Nancy; Bertholet, Sylvie; Duncan, Robert; Nakhasi, Hira L

2003-03-01

In multicellular organisms, cellular growth and development can be controlled by programmed cell death (PCD), which is defined by a sequence of regulated events. However, PCD is thought to have evolved not only to regulate growth and development in multicellular organisms but also to have a functional role in the biology of unicellular organisms. In protozoan parasites and in other unicellular organisms, features of PCD similar to those in multicellular organisms have been reported, suggesting some commonality in the PCD pathway between unicellular and multicellular organisms. However, more extensive studies are needed to fully characterise the PCD pathway and to define the factors that control PCD in the unicellular organisms. The understanding of the PCD pathway in unicellular organisms could delineate the evolutionary origin of this pathway. Further characterisation of the PCD pathway in the unicellular parasites could provide information regarding their pathogenesis, which could be exploited to target new drugs to limit their growth and treat the disease they cause.

Community organizing goes to college: A practice-based model of community organizing to implement environmental strategies to reduce high-risk drinking on college campuses

PubMed Central

Wagoner, Kimberly G.; Rhodes, Scott D.; Lentz, Ashley W.; Wolfson, Mark

2013-01-01

Community organizing is a successful method to leverage resources and build community capacity to identify and intervene upon health issues. However, published accounts documenting the systematic facilitation of the process are limited. This qualitative analysis explored community organizing using data collected as part of the Study to Prevent Alcohol Related Consequences (SPARC), a randomized community trial of 10 North Carolina colleges focused on reducing consequences of high-risk drinking among college students. We sought to develop and confirm use of a community-organizing model, based in practice, illustrating an authentic process of organizing campus and community stakeholders for public health change. Using the grounded theory approach, we analyzed and interpreted data from three waves of individual interviews with full-time community organizers on five SPARC intervention campuses. A five-phase community-organizing model was developed and its use was confirmed. This model may serve as a practical guide for public health interventions utilizing community-organizing approaches. PMID:20530638

Professional Organizations for Pharmacy Students on Satellite Campuses.

PubMed

Scott, Mollie Ashe; McLaughlin, Jacqueline; Shepherd, Greene; Williams, Charlene; Zeeman, Jackie; Joyner, Pamela

2016-06-25

Objective. To evaluate the structure and impact of student organizations on pharmacy school satellite campuses. Methods. Primary administrators from satellite campuses received a 20-question electronic survey. Quantitative data analysis was conducted on survey responses. Results. The most common student organizations on satellite campuses were the American Pharmacists Association (APhA) (93.1%), American Society of Health-System Pharmacists (ASHP) (89.7%), Christian Pharmacists Fellowship International (CPFI) (60.0%), state organizations (51.7%), and local organizations (58.6%). Perceived benefits of satellite campus organizations included opportunities for professional development, student engagement, and service. Barriers to success included small enrollment, communication between campuses, finances, and travel. Conclusion. Student organizations were an important component of the educational experience on pharmacy satellite campuses and allowed students to develop professionally and engage with communities. Challenges included campus size, distance between campuses, and communication.

A strategy to discover new organizers identifies a putative heart organizer

PubMed Central

Anderson, Claire; Khan, Mohsin A. F.; Wong, Frances; Solovieva, Tatiana; Oliveira, Nidia M. M.; Baldock, Richard A.; Tickle, Cheryll; Burt, Dave W.; Stern, Claudio D.

2016-01-01

Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development. PMID:27557800

Leadership development and succession planning in case management.

PubMed

Miodonski, Kathleen; Hines, Patricia

2013-01-01

The director of case management is one of health care's leadership positions most frequently in demand. The lack of qualified and effective case management leaders will continue to be an issue for organizations for years to come, influenced by increasing pressures on health care reimbursement and the aging case management workforce. Organizations have an opportunity to create a program to develop future case management leaders from their internal talent. The proposed strategies are designed for the acute care hospital but also have applicability in other health care settings where there are case managers and a need for case management leadership. The business community offers leadership research and leadership development models with relevance to case management. Identifying and developing internal talent for leadership roles has been proven to be effective in preparation for advanced responsibilities, has a positive effect on staff morale, and minimizes the impact of vacant leadership positions during recruitment and onboarding activities. Creating a case management leadership development program for an organization can be an alternative to the process of external recruitment for case management department leaders. Such a program can be undertaken even in today's budget conscious environment by accessing existing resources in an organization in a creative and organized manner. The authors outline an approach for case management leaders to accept responsibility for succession planning and for case managers to accept responsibility for promoting their own career development through creation of a leadership development program.

A new theory of development: the generation of complexity in ontogenesis.

PubMed

Barbieri, Marcello

2016-03-13

Today there is a very wide consensus on the idea that embryonic development is the result of a genetic programme and of epigenetic processes. Many models have been proposed in this theoretical framework to account for the various aspects of development, and virtually all of them have one thing in common: they do not acknowledge the presence of organic codes (codes between organic molecules) in ontogenesis. Here it is argued instead that embryonic development is a convergent increase in complexity that necessarily requires organic codes and organic memories, and a few examples of such codes are described. This is the code theory of development, a theory that was originally inspired by an algorithm that is capable of reconstructing structures from incomplete information, an algorithm that here is briefly summarized because it makes it intuitively appealing how a convergent increase in complexity can be achieved. The main thesis of the new theory is that the presence of organic codes in ontogenesis is not only a theoretical necessity but, first and foremost, an idea that can be tested and that has already been found to be in agreement with the evidence. © 2016 The Author(s).

The Unique Context of Identity-Based Student Organizations in Developing Leadership.

PubMed

Kodama, Corinne M; Laylo, Rhonda

2017-09-01

This chapter addresses the important role of identity-based student organizations in developing leadership, particularly for students who may feel marginalized because of their racial/ethnic, religious, or gender identities. Understanding the influence of these groups can help leadership educators develop a more inclusive and diverse perspective on student leadership development. © 2017 Wiley Periodicals, Inc., A Wiley Company.

Transmission of West Nile virus from an organ donor to four transplant recipients.

PubMed

Iwamoto, Martha; Jernigan, Daniel B; Guasch, Antonio; Trepka, Mary Jo; Blackmore, Carina G; Hellinger, Walter C; Pham, Si M; Zaki, Sherif; Lanciotti, Robert S; Lance-Parker, Susan E; DiazGranados, Carlos A; Winquist, Andrea G; Perlino, Carl A; Wiersma, Steven; Hillyer, Krista L; Goodman, Jesse L; Marfin, Anthony A; Chamberland, Mary E; Petersen, Lyle R

2003-05-29

In August 2002, fever and mental-status changes developed in recipients of organs from a common donor. Transmission of West Nile virus through organ transplantation was suspected. We reviewed medical records, conducted interviews, and collected blood and tissue samples for testing with a variety of assays. Persons who donated blood to the organ donor and associated blood components were identified and tested for West Nile virus. We identified West Nile virus infection in the organ donor and in all four organ recipients. Encephalitis developed in three of the organ recipients, and febrile illness developed in one. Three recipients became seropositive for West Nile virus IgM antibody; the fourth recipient had brain tissue that was positive for West Nile virus by isolation and nucleic acid and antigen assays. Serum specimens obtained from the organ donor before and immediately after blood transfusions showed no evidence of West Nile virus; however, serum and plasma samples obtained at the time of organ recovery were positive on viral nucleic acid testing and viral culture. The organ donor had received blood transfusions from 63 donors. A review of blood donors and follow-up testing identified one donor who had viremia at the time of donation and who became seropositive for West Nile virus IgM antibodies during the next two months. Our investigation of this cluster documents the transmission of West Nile virus by organ transplantation. Organ recipients receiving immunosuppressive drugs may be at high risk for severe disease after West Nile virus infection. Blood transfusion was the probable source of the West Nile virus viremia in the organ donor. Copyright 2003 Massachusetts Medical Society

ISO 14000 RESOURCE DIRECTORY

EPA Science Inventory

This document, developed through cooperation between EPA's Office of Research and Development and the Office of Prevention, Pesticides and Toxic Substances, is a listing of government and nonprofit organization initiatives and projects related to the International Organization fo...

Affirmative action as organization development at the Johnson Space Center

NASA Technical Reports Server (NTRS)

Tryman, Mfanya Donald L.

1987-01-01

The role of affirmative actions is investigated as an interventionist Organization Development (OD) strategy for insuring equal opportunities at the NASA/Johnson Space Center. In doing so, an eclectic and holistic model is developed for the recruiting and hiring of minorities and females over the next five years. The strategy, approach, and assumptions for the model are quite different than those for JSC's five year plan. The study concludes that Organization development utilizing affirmative action is a valid means to bring about organizational change and renewal processes, and that an eclectic model of affirmative action is most suitable and rational in obtaining this end.

Lessons learned in transitioning to an open systems environment

NASA Technical Reports Server (NTRS)

Boland, Dillard E.; Green, David S.; Steger, Warren L.

1994-01-01

Software development organizations, both commercial and governmental, are undergoing rapid change spurred by developments in the computing industry. To stay competitive, these organizations must adopt new technologies, skills, and practices quickly. Yet even for an organization with a well-developed set of software engineering models and processes, transitioning to a new technology can be expensive and risky. Current industry trends are leading away from traditional mainframe environments and toward the workstation-based, open systems world. This paper presents the experiences of software engineers on three recent projects that pioneered open systems development for NASA's Flight Dynamics Division of the Goddard Space Flight Center (GSFC).

Recent advances in synthetic biosafety

PubMed Central

Simon, Anna J.; Ellington, Andrew D.

2016-01-01

Synthetically engineered organisms hold promise for a broad range of medical, environmental, and industrial applications. Organisms can potentially be designed, for example, for the inexpensive and environmentally benign synthesis of pharmaceuticals and industrial chemicals, for the cleanup of environmental pollutants, and potentially even for biomedical applications such as the targeting of specific diseases or tissues. However, the use of synthetically engineered organisms comes with several reasonable safety concerns, one of which is that the organisms or their genes could escape their intended habitats and cause environmental disruption. Here we review key recent developments in this emerging field of synthetic biocontainment and discuss further developments that might be necessary for the widespread use of synthetic organisms. Specifically, we discuss the history and modern development of three strategies for the containment of synthetic microbes: addiction to an exogenously supplied ligand; self-killing outside of a designated environment; and self-destroying encoded DNA circuitry outside of a designated environment. PMID:27635235

Development of Graft-Site Candidiasis in 3 Solid Organ Transplant Recipients from the Same Donor.

PubMed

El-Bandar, Nasrin; Kroy, Daniela C; Fuller, Tom Florian; Kramer, Jürgen; Liefeldt, Lutz; Budde, Klemens; Blobel, Conrad; Miller, Kurt; Friedersdorff, Frank

2017-07-11

BACKGROUND Graft-site candidiasis rarely develops in solid organ transplant recipients; however, severe life-threatening complications can occur. We report the course of 3 solid organ transplant recipients developing graft-site candidiasis. CASE REPORT All grafts, consisting of 2 kidneys and 1 liver, were procured from a single donor. Patient data were collected from our database. Candida albicans was isolated from a swab taken during multiple-organ recovery. Complications associated with candidiasis occurred in all 3 recipients with preservation of the liver transplant. Both renal transplant recipients had vascular complications, eventually resulting in graft nephrectomy and subsequent return to dialysis. The patients recovered completely without residual effects of their prior fungal infection. CONCLUSIONS Fungal infections in solid organ transplant recipients are rare. Since the sequelae of these infections are serious and usually pertain to more than 1 recipient at a time, antifungal prophylaxis may be warranted in select donors.

The symmetry of man.

PubMed

Ermolenko, Alexander E; Perepada, Elena A

2007-01-01

The paper contains a description of basic regularities in the manifestation of symmetry of human structural organization and its ontogenetic and phylogenetic development. A concept of macrobiocrystalloid with inherent complex symmetry is proposed for the description of the human organism in its integrity. The symmetry can be characterized as two-plane radial (quadrilateral), where the planar symmetry is predominant while the layout of organs of radial symmetry is subordinated to it. Out of the two planes of symmetry (sagittal and horizontal), the sagittal plane is predominant. The symmetry of the chromosome, of the embrio at the early stages of cell cleavage as well as of some organs and systems in their phylogenetic development is described. An hypothesis is postulated that the two-plane symmetry is formed by two mechanisms: a) the impact of morphogenetic fields of the whole crystalloid organism during embriogenesis and, b) genetic mechanisms of the development of chromosomes having two-plane symmetry.

Two generations of the tongue and gustatory organs in the development of Hynobius dunni Tago

PubMed Central

Żuwała, K; Kato, S; Jakubowski, M

2002-01-01

In the development of Hynobius dunni there are two consecutive generations of the tongue and two generations of gustatory organs (taste buds and taste disks). The anlage of the developing secondary tongue appears just in front of the free ending of the primary tongue beginning at the larval developmental stage 62. From stage 67, a gradual reduction in the anterior part of the gill skeleton that supports the primary tongue occurs as the developing secondary tongue replaces the primary one. The lining of the entire oropharyngeal cavity of larvae contains only gustatory organs of the taste bud (TB) type. In younger larvae, the sensory area of a TB has a diameter of between 10 and 13 μm, while in older larvae, TBs reach 16–18 μm in diameter. After metamorphosis, some gustatory organs in the secondary tongue with a sensory area of 26–36 μm in diameter appear. In older animals they may reach as much as 56–71 μm. In other regions of the oropharyngeal epithelium than the tongue, these organs have an ellipsoid shape with a major axis of about 50 μm. On the basis of the cytomorphological criteria established previously, these organs were designated as taste disks. Thus, the presence of two generations of gustatory organs is characteristic of some urodeles, as well as frogs. PMID:12171480

Building Systemwide Improvement Capability: Does an Organization's Strategy for Quality Improvement Matter?

PubMed

Babich, Lauren P; Charns, Martin P; McIntosh, Nathalie; Lerner, Barbara; Burgess, James F; Stolzmann, Kelly L; VanDeusen Lukas, Carol

2016-01-01

Health care organizations have used different strategies to implement quality improvement (QI) programs but with only mixed success in implementing and spreading QI organization-wide. This suggests that certain organizational strategies may be more successful than others in developing an organization's improvement capability. To investigate this, our study examined how the primary focus of grant-funded QI efforts relates to (1) key measures of grant success and (2) organization-level measures of success in QI and organizational learning. Using a mixed-methods design, we conducted one-way analyses of variance to relate Veterans Affairs administrative survey data to data collected as part of a 3.5-year evaluation of 29 health care organization grant recipients. We then analyzed qualitative evidence from the evaluation to explain our results. We found that hospitals that focused on developing organizational infrastructure to support QI implementation compared with those that focused on training or conducting projects rated highest (at α = .05) on all 4 evaluation measures of grant success and all 3 systemwide survey measures of QI and organizational learning success. This study adds to the literature on developing organizational improvement capability and has practical implications for health care leaders. Focusing on either projects or staff training in isolation has limited value. Organizations are more likely to achieve systemwide transformation of improvement capability if their strategy emphasizes developing or strengthening organizational systems, structures, or processes to support direct improvement efforts.

Partnership Among Peers: Lessons Learned From the Development of a Community Organization–Academic Research Training Program

PubMed Central

Jewett-Tennant, Jeri; Collins, Cyleste; Matloub, Jacqueline; Patrick, Alison; Chupp, Mark; Werner, James J.; Borawski, Elaine A.

2017-01-01

Background Community engagement and rigorous science are necessary to address health issues. Increasingly, community health organizations are asked to partner in research. To strengthen such community organization–academic partnerships, increase research capacity in community organizations, and facilitate equitable partnered research, the Partners in Education Evaluation and Research (PEER) program was developed. The program implements an 18-month structured research curriculum for one mid-level employee of a health-focused community-based organization with an organizational mentor and a Case Western Reserve University faculty member as partners. Methods The PEER program was developed and guided by a community–academic advisory committee and was designed to impact the research capacity of organizations through didactic modules and partnered research in the experiential phase. Active participation of community organizations and faculty during all phases of the program provided for bidirectional learning and understanding of the challenges of community-engaged health research. The pilot program evaluation used qualitative and quantitative data collection techniques, including experiences of the participants assessed through surveys, formal group and individual interviews, phone calls, and discussions. Statistical analysis of the change in fellows’ pre-test and post-test survey scores were conducted using paired sample t tests. The small sample size is recognized by the authors as a limitation of the evaluation methods and would potentially be resolved by including more cohort data as the program progresses. Qualitative data were reviewed by two program staff using content and narrative analysis to identify themes, describe and assess group phenomena and determine program improvements. Objectives The objective of PEER is to create equitable partnerships between community organizations and academic partners to further research capacity in said organizations and develop mutually beneficial research partnerships between academia and community organizations. Conclusion PEER demonstrates a commitment to successfully developing sustainable research capacity growth in community organizations, and improved partnered research with academic institutions. PMID:28230553

Organization-based Model-driven Development of High-assurance Multiagent Systems

DTIC Science & Technology

2009-02-27

based Model -driven Development of High-assurance Multiagent Systems " performed by Dr. Scott A . DeLoach and Dr Robby at Kansas State University... A Capabilities Based Model for Artificial Organizations. Journal of Autonomous Agents and Multiagent Systems . Volume 16, no. 1, February 2008, pp...Matson, E . T. (2007). A capabilities based theory of artificial organizations. Journal of Autonomous Agents and Multiagent Systems

Problem Types in Synthetic Organic Chemistry Research: Implications for the Development of Curricular Problems for Second-Year Level Organic Chemistry Instruction

ERIC Educational Resources Information Center

Raker, Jeffrey R.; Towns, Marcy H.

2012-01-01

Understanding of the nature of science is key to the development of new curricular materials that mirror the practice of science. Three problem types (project level, synthetic planning, and day-to-day) in synthetic organic chemistry emerged during a thematic content analysis of the research experiences of eight practising synthetic organic…

Molecular mechanisms of inner ear development.

PubMed

Wu, Doris K; Kelley, Matthew W

2012-08-01

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Hence, the study of inner ear development provides a rich context for understanding the functions of genes implicated in hearing loss. This chapter focuses on molecular mechanisms of inner ear development derived from studies of model organisms.

Orbital Magnetism in Band Structure Calculations

NASA Astrophysics Data System (ADS)

Solovyev, I. V.; Liechtenstein, A. I.; Terakura, K.

1997-03-01

We discuss abilities of the exact Fock exchange EX to deal with the phenomenon of the orbital magnetism in the density functional theories. The essence of our approach is to decompose the density matrix in terms of invariant (Rwidehatρ_i=widehatρ_i) and noninvariant (Rwidehatρ_n=-widehatρ_n) parts under the time reversal operation R. Stressing the short-range electron-electron interactions, we analyze the exchange enhancement of the orbital magnetization given by E_X[widehatρ_n]. For p-electrons it leads to the Stoner-like orbital exchange E_X[widehatρ_n]=-(1/4)Usum_α < widehatL_α >^2 driven by on-site Coulomb interaction U. More generally, E_X[widehatρ_n] can be expressed in terms of expectation values of the irreducible set of operators being odd order products of widehatL_x, widehatLy and widehatL_z. Local enhancement of the crystal field effects in E_X[widehatρ_i] as well as Hartree term E_H[widehatρ_i] relevant to the quenching of the orbital moments is driven by the same parameter (U) and should be considered on an equal footing with E_X[widehatρ_n]. We have implemented this formalism in the spirit of rotationally invariant LDA+U approach^1 in the fully relativistic LMTO method. Applications for Fe, Co and Ni as well as FeO and CoO will be given. - The work is partly supported by NEDO. ^1 I.V.Solovyev et al., Phys. Rev. B 50, 16861 (1994), A.I.Liechtenstein et al., Phys. Rev. B 52, R5467 (1995).

31 CFR Appendix A to Part 500 - Qualifying International Institutions

Code of Federal Regulations, 2010 CFR

2010-07-01

... Organization (UNIDO) UN International Drug Control Program (UNIDCP) UN Population Fund (UNPF) World Health Organization (WHO) World Meteorological Organization (WMO) [58 FR 68532, Dec. 28, 1993] ... (IBRD, the “World Bank”) International Civil Aviation Organization (ICAO) International Development...

Partnering with youth organizers to prevent violence: an analysis of relationships, power, and change.

PubMed

Peterson, Tessa Hicks; Dolan, Tom; Hanft, Sam

2010-01-01

Youth from the city of San Bernardino, California, launched a community organizing campaign to develop policy changes to address conditions of inter-racial violence in their community. Pitzer College students collaborated with the high school youth organizers in a community-based participatory research (CBPR) project to study violence and racial conflict at local high schools. The purpose of the project was to explore the experiences and perceptions of high school youth about racial conflict in their community and to develop policy proposals to address this issue. Undergraduate student researchers and high school youth organizers collaborated in designing and conducting narrative research. Together they developed questions and carried out semi-structured interviews and two focus groups with 40 local youth. The undergraduate students then coded and analyzed the data to identify common themes. Youth organizer's feedback was incorporated into a final, shared research report, including policy proposals, which were presented to the greater community. Youth organizers worked with city and school administrators to secure the implementation of programs they recommended to address their research's findings. Programs were enacted to reduce racial bias and conflict on school campuses, and city leaders agreed to develop a strategic youth development plan together with youth organizers. The partnership experience supported important policy changes in San Bernardino high schools, yet also illuminated areas wherein the community-campus partnerships could work more intentionally to shift power dynamics between and within the partners, address conditions that generate dependency and inequality in the partnership, and expand outcomes of institutional and community transformation.

Stacked color image sensor using wavelength-selective organic photoconductive films with zinc-oxide thin film transistors as a signal readout circuit

NASA Astrophysics Data System (ADS)

Seo, Hokuto; Aihara, Satoshi; Namba, Masakazu; Watabe, Toshihisa; Ohtake, Hiroshi; Kubota, Misao; Egami, Norifumi; Hiramatsu, Takahiro; Matsuda, Tokiyoshi; Furuta, Mamoru; Nitta, Hiroshi; Hirao, Takashi

2010-01-01

Our group has been developing a new type of image sensor overlaid with three organic photoconductive films, which are individually sensitive to only one of the primary color components (blue (B), green (G), or red (R) light), with the aim of developing a compact, high resolution color camera without any color separation optical systems. In this paper, we firstly revealed the unique characteristics of organic photoconductive films. Only choosing organic materials can tune the photoconductive properties of the film, especially excellent wavelength selectivities which are good enough to divide the incident light into three primary colors. Color separation with vertically stacked organic films was also shown. In addition, the high-resolution of organic photoconductive films sufficient for high-definition television (HDTV) was confirmed in a shooting experiment using a camera tube. Secondly, as a step toward our goal, we fabricated a stacked organic image sensor with G- and R-sensitive organic photoconductive films, each of which had a zinc oxide (ZnO) thin film transistor (TFT) readout circuit, and demonstrated image pickup at a TV frame rate. A color image with a resolution corresponding to the pixel number of the ZnO TFT readout circuit was obtained from the stacked image sensor. These results show the potential for the development of high-resolution prism-less color cameras with stacked organic photoconductive films.

Clinical program leadership: skill requirements for contemporary leaders.

PubMed

Spallina, Joseph M

2002-01-01

With knowledge of these leadership requirements and a shrinking base of experienced managers, healthcare organizations and professional societies have little choice in their approach to prepare for the leadership development challenges of the future. Organizations will focus leadership development, training, and continuing management education on integrating business tools and skills into clinical program management. The management requirements for clinical programs will continue to grow in complexity and the number of qualified managers will continue to diminish, New approaches to solving this shortage will evolve. Professional, forprofit companies, healthcare provider organizations, and academic programs will develop clinical program management training tracks. Organizations that create solutions to this management imperative will maintain their competitive edge in the challenging times that will greet the industry in the future.

Methodical approaches to providing sustainable development of the transport industry management system based on self-organization

NASA Astrophysics Data System (ADS)

Belyantseva, Oksana; Panenkov, Andrey; Safonova, Nataliya

2017-10-01

Current conditions of the cognitive economy formation demand to take into account the leading role of information, knowledge and human capital in the development of the transport industry management system. The article substantiates the conceptual approach to the self-organization of a management system on the basis of innovative changes. Human capital is the key aspect of self-organization, so the directions of improving the workforce quality are justified. Basing on the information-innovative genesis of the process of self-organization, the authors justified the necessity of preventing asymmetric information. For this pupose the actions against the resistance to innovations were proposed. The implementation of certain measures contributes to the effective development of the transport management system.

Perovskite and Organic Photovoltaics | Photovoltaic Research | NREL

Science.gov Websites

Perovskite and Organic Photovoltaics Perovskite and Organic Photovoltaics Scientist holds several solar cells; 2) electronic energy level alignment at the carbon nanotube/organic metal halide perovskite Hest in the PDIL in the S and TF at NREL. Organic Photovoltaics (OPV) We develop and apply new absorber

Relationships between Organizations and Publics: Development of a Multi-Dimensional Organization-Public Relationship Scale.

ERIC Educational Resources Information Center

Bruning, Stephen D.; Ledingham, John A.

1999-01-01

Attempts to design a multiple-item, multiple-dimension organization/public relationship scale. Finds that organizations and key publics have three types of relationships: professional, personal, and community. Provides an instrument that can be used to measure the influence that perceptions of the organization/public relationship have on consumer…

Oxygen and Biological Evolution.

ERIC Educational Resources Information Center

Baugh, Mark A.

1990-01-01

Discussed is the evolution of aerobic organisms from anaerobic organisms and the accompanying biochemistry that developed to motivate and enable this evolution. Uses of oxygen by aerobic organisms are described. (CW)

The Unity Council at 40: a pioneering community development and service organization (1967-2007).

PubMed

Orozco, Gabriel; Schwartz, Sara L; Austin, Michael J

2011-01-01

The Spanish Speaking Unity Council (Unity Council) is a community development nonprofit organization that was established in 1964, during the civil rights movement, by a group of community members who wanted to ensure the political representation of the Latino community. Over its 45-year history, the Unity Council has grown into a $12 million community development organization that delivers a range of programming, including social services and employment training as well as facilitating the development and support of local businesses, low-income housing, and neighborhood improvement activities. The history of the agency presents the multiple challenges and rewards associated with development in an underserved community and an example of the important role that leadership plays in the growth of a nonprofit.

(PRESENTED AT MATSUYAMA, JAPAN) PERSISTENT PERFLUORINATED ORGANIC COMPOUNDS METHOD DEVELOPMENT RESEARCH AT THE U.S. ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

PowerPoint presentation summarizing method development research involving the persistent perfluorinated organic compounds. Review of data indicating widespread distribution of these materials and the potential for toxicity.

(PRESENTED AT TSUKUBA, JAPAN) PERSISTENT PERFLUORINATED ORGANIC COMPOUNDS METHOD DEVELOPMENT RESEARCH AT THE U.S. ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

PowerPoint presentation summarizing method development research involving the persistent perfluorinated organic compounds. Review of data indicating widespread distribution of these materials and the potential for toxicity.

Electronic Dissemination of UN Agency Information.

ERIC Educational Resources Information Center

Stratford, Jean Slemmons; Stratford, Juri

1997-01-01

Highlights information, available electronically, about products and services by the United Nations (UN), UN Development Programme, High Commission for Refugees, UNICEF, Fund for Population Activities, Economic Commissions, Industrial Development Organization, International Labor Organization, UNESCO, Environment Program, World Meteorological…

Designing Assessment Strategies for Organization Development

ERIC Educational Resources Information Center

Nielsen, Warren R.; Kimberly, John R.

1976-01-01

Argues that systematic empirical assessment of organizational development (OD) interventions is important and can have benefits both for subject organizations and organizational researchers. Discusses suggested criteria for effective assessment of OD interventions. (For availability see EA 507 198.) (JG)

Planning for organization development in operations control centers.

DOT National Transportation Integrated Search

2012-06-01

The first step in a proposed program of organization development (OD) was to assess organizational processes within the : Technical Operations Services (TechOps) Operations Control Centers (OCCs). The aim of the OD program was to : improve effectiven...

A Conceptual Model for Supporting Para-Teacher Learning in an Indian Non-Governmental Organization (NGO)

ERIC Educational Resources Information Center

Raval, Harini; McKenney, Susan; Pieters, Jules

2010-01-01

Non-governmental organizations (NGOs) are being recognized globally for their influential role in realizing the UN Millennium Development Goal of education for all in developing countries. NGOs mostly employ untrained para-educators for grassroots activities. The professional development of these teachers is critical for NGO effectiveness, yet…

Selecting Organization Development Theory from an HRD Perspective

ERIC Educational Resources Information Center

Lynham, Susan A.; Chermack, Thomas J.; Noggle, Melissa A.

2004-01-01

As is true for human resource development (HRD), the field of organization development (OD) draws from numerous disciplines to inform its theory base. However, the identification and selection of theory to inform improved practice remains a challenge and begs the question of what can be used to inform and guide one in the identification and…

Software Development Standard for Mission Critical Systems

DTIC Science & Technology

2014-03-17

new development, modification, reuse, reengineering, maintenance , or any other activity or combination of activities resulting in products . Within...develops” includes new development, modification, integration, reuse, reengineering, maintenance , or any other activity that results in products ... Maintenance organization. The organization that is responsible for modifying and otherwise sustaining the software and other software products and

78 FR 44959 - Public Workshop Related to the International Maritime Organization's Development of a Mandatory...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-25

... the International Maritime Organization's Development of a Mandatory Code for Ships Operating in Polar... States Coast Guard will hold a public workshop in Washington, DC on topics related to the development of... Polar Code). Various safety topics will be discussed including design, equipment, and operational...

Examining Agency Theory in Training & Development: Understanding Self-Interest Behaviors in the Organization

ERIC Educational Resources Information Center

Azevedo, Ross E.; Akdere, Mesut

2011-01-01

Agency theory has been discussed widely in the business and management literature. However, to date there has been no investigation about its utility and implications for problems in training & development. Whereas organizations are still struggling to develop and implement effective training programs, there is little emphasis on the self-interest…

Gamification - Environmental and Sustainable Development Organizations Could Do More

NASA Astrophysics Data System (ADS)

Ziegler, C. R.; Miller, C. A.; Kilaru, V.; French, R. A.; Costanza, R.; Brookes, A.

2013-12-01

The use of digital games to foster sustainable development and environmental goals has grown over the last 10 years. Innovative thinking and the origins of 'serious games,' 'games for change' and 'gamification' are partly rooted in movies and science fiction. Existing games illustrate a spectrum of approaches: for example, World Food Programme's FoodForce and University of Washington's Foldit. Environmental organizations globally (e.g. US EPA) have dabbled with game development and gamification, but have only touched the tip of the iceberg, particularly when compared to the success of the commercial gaming industry. We explore: 1) the intersection of environmental organization mission statements in the context of gamification efforts , 2) some examples of existing games, from simple to complex, 3) business model approaches (e.g. game development partnerships with academia, private industry, NGOs, etc.), 4) barriers, and 5) benefits of a more concerted and technologically-advanced approach to gamification for environmental organizations.

Deriving Sediment Interstitial Water Remediation Goals ...

EPA Pesticide Factsheets

This document contains a methodology for developing interstitial water remediation goals (IWRGs) for nonionic organic pollutants (toxicants) in sediments for the protection of benthic organisms. The document provides the basis for using the final chronic values (FCVs) from EPA’s aquatic water quality criteria (AWQC) for the protection of aquatic life to set the IWRGs for toxicants in sediments. Concentrations of the toxicants in the sediment interstitial water are measured using passive sampling. This document also discusses how to evaluate the consistency between passive sampling measurements and sediment toxicity test results. When these data are consistent, one can be reasonably assured that the causes of toxicity to benthic organisms in the sediment have been correctly identified and that the developed IWRGs for the toxicants will be protective of the benthic organisms at the site. The consistency evaluation is an important step in developing defensible IWRGs. To assist in developing defensible IWRGs.

Isolation and chemical characterization of dissolved and colloidal organic matter

USGS Publications Warehouse

Aiken, G.; Leenheer, J.

1993-01-01

Commonly used techniques for the concentration and isolation of organic matter from water, such as preparative chromatography, ultrafiltration and reverse osmosis, and the methods used to analyze the organic matter obtained by these methods are reviewed. The development of methods to obtain organic matter that is associated with fractions of the dissolved organic carbon other than humic substances, such as organic bases, hydrophilic organic acids and colloidal organic matter are discussed. Methods specifically used to study dissolved organic nitrogen and dissolved organic phosphorous are also discussed. -from Authors

Searching for the right fit: development of applicant person-organization fit perceptions during the recruitment process.

PubMed

Swider, Brian W; Zimmerman, Ryan D; Barrick, Murray R

2015-05-01

Numerous studies link applicant fit perceptions measured at a single point in time to recruitment outcomes. Expanding upon this prior research by incorporating decision-making theory, this study examines how applicants develop these fit perceptions over the duration of the recruitment process, showing meaningful changes in fit perceptions across and within organizations overtime. To assess the development of applicant fit perceptions, eight assessments of person-organization (PO) fit with up to four different organizations across 169 applicants for 403 job choice decisions were analyzed. Results showed the presence of initial levels and changes in differentiation of applicant PO fit perceptions across organizations, which significantly predicted future job choice. In addition, changes in within-organizational PO fit perceptions across two stages of recruitment predicted applicant job choices among multiple employers. The implications of these results for accurately understanding the development of fit perceptions, relationships between fit perceptions and key recruiting outcomes, and possible limitations of past meta-analytically derived estimates of these relationships are discussed. (c) 2015 APA, all rights reserved.

Upstream paths for Hippo signaling in Drosophila organ development.

PubMed

Choi, Kwang-Wook

2018-03-01

Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional coactivator Yorkie (Yki). Activation of Yki promotes cell survival and proliferation to induce organ growth. A key issue in Hippo signaling is to understand how core kinase cascade is activated. Activation of Hippo kinase cascade is regulated in the upstream by at least two transmembrane proteins Crumbs and Fat that act in parallel. These membrane proteins interact with additional factors such as FERM-domain proteins Expanded and Merlin to modulate subcellular localization and function of the Hippo kinase cascade. Hippo signaling is also influenced by cytoskeletal networks and cell tension in epithelia of developing organs. These upstream events in the regulation of Hippo signaling are only partially understood. This review focuses on our current understanding of some upstream processes involved in Hippo signaling in developing Drosophila organs. [BMB Reports 2018; 51(3): 134-142].

Recent developments in organic redox flow batteries: A critical review

NASA Astrophysics Data System (ADS)

Leung, P.; Shah, A. A.; Sanz, L.; Flox, C.; Morante, J. R.; Xu, Q.; Mohamed, M. R.; Ponce de León, C.; Walsh, F. C.

2017-08-01

Redox flow batteries (RFBs) have emerged as prime candidates for energy storage on the medium and large scales, particularly at the grid scale. The demand for versatile energy storage continues to increase as more electrical energy is generated from intermittent renewable sources. A major barrier in the way of broad deployment and deep market penetration is the use of expensive metals as the active species in the electrolytes. The use of organic redox couples in aqueous or non-aqueous electrolytes is a promising approach to reducing the overall cost in long-term, since these materials can be low-cost and abundant. The performance of such redox couples can be tuned by modifying their chemical structure. In recent years, significant developments in organic redox flow batteries has taken place, with the introduction of new groups of highly soluble organic molecules, capable of providing a cell voltage and charge capacity comparable to conventional metal-based systems. This review summarises the fundamental developments and characterization of organic redox flow batteries from both the chemistry and materials perspectives. The latest advances, future challenges and opportunities for further development are discussed.

Tomato Flower Abnormalities Induced by Low Temperatures Are Associated with Changes of Expression of MADS-Box Genes1

PubMed Central

Lozano, Rafael; Angosto, Trinidad; Gómez, Pedro; Payán, Carmen; Capel, Juan; Huijser, Peter; Salinas, Julio; Martínez-Zapater, José M.

1998-01-01

Flower and fruit development in tomato (Lycopersicon esculentum Mill.) were severely affected when plants were grown at low temperatures, displaying homeotic and meristic transformations and alterations in the fusion pattern of the organs. Most of these homeotic transformations modified the identity of stamens and carpels, giving rise to intermediate organs. Complete homeotic transformations were rarely found and always affected organs of the reproductive whorls. Meristic transformations were also commonly observed in the reproductive whorls, which developed with an excessive number of organs. Scanning electron microscopy revealed that meristic transformations take place very early in the development of the flower and are related to a significant increase in the floral meristem size. However, homeotic transformations should occur later during the development of the organ primordia. Steady-state levels of transcripts corresponding to tomato MADS-box genes TM4, TM5, TM6, and TAG1 were greatly increased by low temperatures and could be related to these flower abnormalities. Moreover, in situ hybridization analyses showed that low temperatures also altered the stage-specific expression of TM4. PMID:9576778

3D Biofabrication Strategies for Tissue Engineering and Regenerative Medicine

PubMed Central

Bajaj, Piyush; Schweller, Ryan M.; Khademhosseini, Ali; West, Jennifer L.; Bashir, Rashid

2014-01-01

Over the past several decades, there has been an ever-increasing demand for organ transplants. However, there is a severe shortage of donor organs, and as a result of the increasing demand, the gap between supply and demand continues to widen. A potential solution to this problem is to grow or fabricate organs using biomaterial scaffolds and a person’s own cells. Although the realization of this solution has been limited, the development of new biofabrication approaches has made it more realistic. This review provides an overview of natural and synthetic biomaterials that have been used for organ/tissue development. It then discusses past and current biofabrication techniques, with a brief explanation of the state of the art. Finally, the review highlights the need for combining vascularization strategies with current biofabrication techniques. Given the multitude of applications of biofabrication technologies, from organ/tissue development to drug discovery/screening to development of complex in vitro models of human diseases, these manufacturing technologies can have a significant impact on the future of medicine and health care. PMID:24905875

Competency-based training model for human resource management and development in public sector

NASA Astrophysics Data System (ADS)

Prabawati, I.; Meirinawati; AOktariyanda, T.

2018-01-01

Human Resources (HR) is a very important factor in an organization so that human resources are required to have the ability, skill or competence in order to be able to carry out the vision and mission of the organization. Competence includes a number of attributes attached to the individual which is a combination of knowledge, skills, and behaviors that can be used as a mean to improve performance. Concerned to the demands of human resources that should have the knowledge, skills or abilities, it is necessary to the development of human resources in public organizations. One form of human resource development is Competency-Based Training (CBT). CBT focuses on three issues, namely skills, competencies, and competency standard. There are 5 (five) strategies in the implementation of CBT, namely: organizational scanning, strategic planning, competency profiling, competency gap analysis, and competency development. Finally, through CBT the employees within the organization can reduce or eliminate the differences between existing performance with a potential performance that can improve the knowledge, expertise, and skills that are very supportive in achieving the vision and mission of the organization.

Calculation of Organ Doses for a Large Number of Patients Undergoing CT Examinations.

PubMed

Bahadori, Amir; Miglioretti, Diana; Kruger, Randell; Flynn, Michael; Weinmann, Sheila; Smith-Bindman, Rebecca; Lee, Choonsik

2015-10-01

The objective of our study was to develop an automated calculation method to provide organ dose assessment for a large cohort of pediatric and adult patients undergoing CT examinations. We adopted two dose libraries that were previously published: the volume CT dose index-normalized organ dose library and the tube current-exposure time product (100 mAs)-normalized weighted CT dose index library. We developed an algorithm to calculate organ doses using the two dose libraries and the CT parameters available from DICOM data. We calculated organ doses for pediatric (n = 2499) and adult (n = 2043) CT examinations randomly selected from four health care systems in the United States and compared the adult organ doses with the values calculated from the ImPACT calculator. The median brain dose was 20 mGy (pediatric) and 24 mGy (adult), and the brain dose was greater than 40 mGy for 11% (pediatric) and 18% (adult) of the head CT studies. Both the National Cancer Institute (NCI) and ImPACT methods provided similar organ doses (median discrepancy < 20%) for all organs except the organs located close to the scanning boundaries. The visual comparisons of scanning coverage and phantom anatomies revealed that the NCI method, which is based on realistic computational phantoms, provides more accurate organ doses than the ImPACT method. The automated organ dose calculation method developed in this study reduces the time needed to calculate doses for a large number of patients. We have successfully used this method for a variety of CT-related studies including retrospective epidemiologic studies and CT dose trend analysis studies.

Deceased Donor Organs: What Can Be Done to Raise Donation Rates Using Evidence From Malaysia?

PubMed

Rasiah, R; Manikam, R; Chandrasekaran, S K; Naghavi, N; Mubarik, S; Mustafa, R; Pushparajan, S

2016-05-01

Organ donation rates have continued to fall seriously short of needs worldwide, with the lowest rates recorded among developing economies. This study seeks to analyze evidence from a developing economy to explore the usefulness of social psychological theory to solve the problem. The study deployed a large survey (n = 10 412) using a convenience sampling procedure targeted at increasing the number of Malaysians registered with the Ministry of Health, Malaysia who are willing to donate organs upon death. Structural equation modeling was deployed to estimate simultaneously the relative influence of cognitive and noncognitive variables on willingness to donate deceased organs. The cognitive factors of donation perception, socioeconomic status and financial incentives, and the noncognitive factors of demography and fear showed a high statistically significant (1%) relationship with willingness to donate organs after death. While financial incentives were significant, cash rewards showed the least impact. Donation perception showed the highest impact, which shows that the development of effective pedagogic programs with simultaneous improvements to the quality of services provided by medical personnel engaged in retrieving and transplanting deceased donor organs can help raise organ donation rates. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

Integration of systems biology with organs-on-chips to humanize therapeutic development

NASA Astrophysics Data System (ADS)

Edington, Collin D.; Cirit, Murat; Chen, Wen Li Kelly; Clark, Amanda M.; Wells, Alan; Trumper, David L.; Griffith, Linda G.

2017-02-01

"Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell and intracellular signaling networks in patient-derived samples; 3D tissue engineered models of human organ systems, often made from stem cells; and micro-fluidic and meso-fluidic devices that enable living systems to be sustained, perturbed and analyzed for weeks in culture. Integration of these rapidly moving fields has the potential to revolutionize development of therapeutics for complex, chronic diseases, including those that have weak genetic bases and substantial contributions from gene-environment interactions. Technical challenges in modeling complex diseases with "organs on chips" approaches include the need for relatively large tissue masses and organ-organ cross talk to capture systemic effects, such that current microfluidic formats often fail to capture the required scale and complexity for interconnected systems. These constraints drive development of new strategies for designing in vitro models, including perfusing organ models, as well as "mesofluidic" pumping and circulation in platforms connecting several organ systems, to achieve the appropriate physiological relevance.

DEHYDRATION OF ALCOHOLS VIA PREVAPORATION USING A NOVEL HYDROPHILIC MEMBRANE

EPA Science Inventory

Pervaporation has emerged as an economically viable alternative technology for the dehydration of organic solvents, removal of organic compounds from water and organic/organic separations. Development of a suitable membrane system with high flux and high selectivity plays a criti...

22 CFR 228.32 - Nonprofit organizations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Nonprofit organizations. 228.32 Section 228.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON SOURCE, ORIGIN AND NATIONALITY FOR... USAID Financing § 228.32 Nonprofit organizations. (a) Nonprofit organizations, such as educational...

DEHYDRATION OF ALCOHOLS VIA PERVAPORATION USING A NOVEL HYDROHILIC MEMBRANE

EPA Science Inventory

Pervaporation has emerged as an economically viable alternative technology for the dehydration of organic solvents, removal of organic compounds from water and organic/organic separations. Development of a suitable membrane system with high flux and high selectivity plays a criti...

42 CFR 486.348 - Condition: Quality assessment and performance improvement (QAPI).

Code of Federal Regulations, 2010 CFR

2010-10-01

... improvement (QAPI). 486.348 Section 486.348 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Coverage: Organ Procurement Organizations Organ Procurement Organization Process Performance Measures § 486.348 Condition: Quality assessment and performance improvement (QAPI). The OPO must develop, implement...

22 CFR 226.82 - Program income.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Additional Provisions For Awards to Commercial Organizations § 226.82 Program income. The... commercial organization. ...

A mechanistic link between gene regulation and genome architecture in mammalian development.

PubMed

Bonora, Giancarlo; Plath, Kathrin; Denholtz, Matthew

2014-08-01

The organization of chromatin within the nucleus and the regulation of transcription are tightly linked. Recently, mechanisms underlying this relationship have been uncovered. By defining the organizational hierarchy of the genome, determining changes in chromatin organization associated with changes in cell identity, and describing chromatin organization within the context of linear genomic features (such as chromatin modifications and transcription factor binding) and architectural proteins (including Cohesin, CTCF, and Mediator), a new paradigm in genome biology was established wherein genomes are organized around gene regulatory factors that govern cell identity. As such, chromatin organization plays a central role in establishing and maintaining cell state during development, with gene regulation and genome organization being mutually dependent effectors of cell identity. Copyright © 2014 Elsevier Ltd. All rights reserved.

Regenerative immunology: the immunological reaction to biomaterials.

PubMed

Cravedi, Paolo; Farouk, Samira; Angeletti, Andrea; Edgar, Lauren; Tamburrini, Riccardo; Duisit, Jerome; Perin, Laura; Orlando, Giuseppe

2017-12-01

Regenerative medicine promises to meet two of the most urgent needs of modern organ transplantation, namely immunosuppression-free transplantation and an inexhaustible source of organs. Ideally, bioengineered organs would be manufactured from a patient's own biomaterials-both cells and the supporting scaffolding materials in which cells would be embedded and allowed to mature to eventually regenerate the organ in question. While some groups are focusing on the feasibility of this approach, few are focusing on the immunogenicity of the scaffolds that are being developed for organ bioengineering purposes. This review will succinctly discuss progress in the understanding of immunological characteristics and behavior of different scaffolds currently under development, with emphasis on the extracellular matrix scaffolds obtained decellularized animal or human organs which seem to provide the ideal template for bioengineering purposes. © 2017 Steunstichting ESOT.

Tailored Systems Architecture for Design of Space Science and Technology Missions Using DoDAF V2.0

DTIC Science & Technology

2009-12-01

programs do exist. Given the focus on rapid development and transition, if a system architecture framework could be developed and used to increase ...and scope are still being developed and refined at all levels within the DoD. As organizations have attempted to develop system architectures that...to produce architecture descriptions during the early-stages of system development. (3 p. 19) conformance, organizations ultimately using the

EvalPartners: Facilitating the Development of a New Model of Voluntary Organization for Professional Evaluation to Support the Development of National Evaluation Capacities

ERIC Educational Resources Information Center

Kosheleva, Natalia; Segone, Marco

2013-01-01

In many less developed democracies Voluntary Organizations for Professional Evaluation (VOPEs) face the challenges of low demand for evaluation and the resulting low economic capacity of national evaluation communities. The VOPE model that evolved in well-developed democracies is not directly applicable under these circumstances, so a new model…

Execution and executability

NASA Astrophysics Data System (ADS)

Bradford, Robert W.; Harrison, Denise

2015-09-01

"We have a new strategy to grow our organization." Developing the plan is just the start. Implementing it in the organization is the real challenge. Many organizations don't fail due to lack of strategy; they struggle because it isn't effectively implemented. After working with hundreds of companies on strategy development, Denise and Robert have distilled the critical areas where organizations need to focus in order to enhance profitability through superior execution. If these questions are important to your organization, you'll find useful answers in the following articles: Do you find yourself overwhelmed by too many competing priorities? How do you limit how many strategic initiatives/projects your organization is working on at one time? How do you balance your resource requirements (time and money) with the availability of these resources? How do you balance your strategic initiative requirements with the day-to-day requirements of your organization?

3D Bioprinting of Tissue/Organ Models.

PubMed

Pati, Falguni; Gantelius, Jesper; Svahn, Helene Andersson

2016-04-04

In vitro tissue/organ models are useful platforms that can facilitate systematic, repetitive, and quantitative investigations of drugs/chemicals. The primary objective when developing tissue/organ models is to reproduce physiologically relevant functions that typically require complex culture systems. Bioprinting offers exciting prospects for constructing 3D tissue/organ models, as it enables the reproducible, automated production of complex living tissues. Bioprinted tissues/organs may prove useful for screening novel compounds or predicting toxicity, as the spatial and chemical complexity inherent to native tissues/organs can be recreated. In this Review, we highlight the importance of developing 3D in vitro tissue/organ models by 3D bioprinting techniques, characterization of these models for evaluating their resemblance to native tissue, and their application in the prioritization of lead candidates, toxicity testing, and as disease/tumor models. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Preparation of pentacene thin film deposited using organic material auto-feeding system for the fabrication of organic thin film transistor.

PubMed

Kim, Young Baek; Choi, Bum Ho; Lim, Yong Hwan; Yoo, Ha Na; Lee, Jong Ho; Kim, Jin Hyeok

2011-02-01

In this study, pentacene organic thin film was prepared using newly developed organic material auto-feeding system integrated with linear cell and characterized. The newly developed organic material auto-feeding system consists of 4 major parts: reservoir, micro auto-feeder, vaporizer, and linear cell. The deposition of organic thin film could be precisely controlled by adjusting feeding rate, main tube size, position and size of nozzle. 10 nm thick pentacene thin film prepared on glass substrate exhibited high uniformity of 3.46% which is higher than that of conventional evaporation method using point cell. The continuous deposition without replenishment of organic material can be performed over 144 hours with regulated deposition control. The grain size of pentacene film which affect to mobility of OTFT, was controlled as a function of the temperature.

Two-plane symmetry in the structural organization of man.

PubMed

Ermolenko, A E

2005-01-01

Manifestations of symmetry in the human structural organization in ontogenesis and phylogenetic development are analysed. A concept of macrobiocrystalloid with inherent complex symmetry is proposed for the description of the human organism in its integrity. The symmetry can be characterized as two-plane radial (quadrilateral), where the planar symmetry is predominant while the layout of organs of radial symmetry is subordinated to it. Out of the two planes of symmetry (sagittal and horizontal), the sagittal plane is predominant: (a) the location of the organs is governed by two principles: in compliance with the symmetry planes and in compliance with the radial symmetry around cavities; (b) the location of the radial symmetry organs is also governed by the principle of two-plane symmetry; (c) out of the four antimeres of two-plane symmetry, two are paired while the other two have merged into one organ; (d) some organs which are antimeres relative to the horizontal plane are located at the cranial end of the organism (sensory organs, cerebrum-cerebellum, heart-spleen and others). The two-plane symmetry is formed by two mechanisms--(a) the impact of morphogenetic fields of the whole crystalloid organism during embriogenesis and (b) genetic mechanisms of the development of chromosomes having two-plane symmetry. When comparing mineral and biological entities we should consider not the whole immobile crystal but only the active superficial part of a growing or dissolving crystal, the interface between the crystal surface and the crystal-forming environment which directly controls crystal growth and adapts itself to it, as well as crystal feed stock expressed in the structure of concentration flows. The symmetry of the chromosome, of the embrion at the early stages of cell cleavage as well as of some organs and systems in their phylogenetic development is described.

Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.

PubMed

Carcillo, Joseph A; Halstead, E Scott; Hall, Mark W; Nguyen, Trung C; Reeder, Ron; Aneja, Rajesh; Shakoory, Bita; Simon, Dennis

2017-06-01

We hypothesize that three inflammation pathobiology phenotypes are associated with increased inflammation, proclivity to develop features of macrophage activation syndrome, and multiple organ failure-related death in pediatric severe sepsis. Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple organ failure (whole blood ex vivo tumor necrosis factor response to endotoxin < 200 pg/mL), 2) thrombocytopenia-associated multiple organ failure (new onset thrombocytopenia with acute kidney injury and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity < 57%), and/or 3) sequential multiple organ failure with hepatobiliary dysfunction (respiratory distress followed by liver dysfunction with soluble Fas ligand > 200 pg/mL), to those without any of these phenotypes. Tertiary children's hospital PICU. One hundred consecutive severe sepsis admissions. Clinical data were recorded daily, and blood was collected twice weekly. Multiple organ failure developed in 75 cases and eight died. Multiple organ failure cases with any of the three inflammation phenotypes (n = 37) had higher inflammation (C-reactive protein, p = 0.009 and ferritin, p < 0.001) than multiple organ failure cases without any of these phenotypes (n = 38) or cases with only single organ failure (n = 25). Development of features of macrophage activation syndrome and death were more common among multiple organ failure cases with any of the phenotypes (macrophage activation syndrome: 10/37, 27%; death: 8/37, 22%) compared to multiple organ failure cases without any phenotype (macrophage activation syndrome: 1/38, 3%; p = 0.003 and death: 0/38, 0%; p = 0.002). Our approach to phenotype categorization remains hypothetical, and the phenotypes identified need to be confirmed in multicenter studies of pediatric multiple organ dysfunction syndrome.

From Three-Dimensional Cell Culture to Organs-on-Chips

PubMed Central

Huh, Dongeun; Hamilton, Geraldine A.; Ingber, Donald E.

2014-01-01

Three-dimensional (3D) cell culture models have recently garnered great attention because they often promote levels of cell differentiation and tissue organization not possible in conventional two-dimensional (2D) culture systems. Here, we review new advances in 3D culture that leverage microfabrication technologies from the microchip industry and microfluidics approaches to create cell culture microenvironments that both support tissue differentiation and recapitulate the tissue-tissue interfaces, spatiotemporal chemical gradients, and mechanical microenvironments of living organs. These ‘organs-on-chips’ permit study of human physiology in an organ-specific context, enable development of novel in vitro disease models, and could potentially serve as replacements for animals used in drug development and toxin testing. PMID:22033488

Class and ethnicity in the global market for organs: the case of Korean cinema.

PubMed

Garden, Rebecca; Yoo Murphree, Hyon Joo

2007-12-01

While organ transplantation has been established in the medical imagination since the 1960s, this technology is currently undergoing a popular re-imagination in the era of global capitalism. As transplantation procedures have become routine in medical centers in non-Western and developing nations and as organ sales and transplant tourism become increasingly common, organs that function as a material resource increasingly derive from subaltern bodies. This essay explores this development as represented in Korean filmmaker Park Chan-wook's 2002 Sympathy for Mr. Vengeance, focusing on the ethnic and class characteristics of the global market in organs and possible modes of counter-logic to transplant technologies and related ethical discourses.

Muscle organizers in Drosophila: the role of persistent larval fibers in adult flight muscle development

NASA Technical Reports Server (NTRS)

Farrell, E. R.; Fernandes, J.; Keshishian, H.

1996-01-01

In many organisms muscle formation depends on specialized cells that prefigure the pattern of the musculature and serve as templates for myoblast organization and fusion. These include muscle pioneers in insects and muscle organizing cells in leech. In Drosophila, muscle founder cells have been proposed to play a similar role in organizing larval muscle development during embryogenesis. During metamorphosis in Drosophila, following histolysis of most of the larval musculature, there is a second round of myogenesis that gives rise to the adult muscles. It is not known whether muscle founder cells organize the development of these muscles. However, in the thorax specific larval muscle fibers do not histolyze at the onset of metamorphosis, but instead serve as templates for the formation of a subset of adult muscles, the dorsal longitudinal flight muscles (DLMs). Because these persistent larval muscle fibers appear to be functioning in many respects like muscle founder cells, we investigated whether they were necessary for DLM development by using a microbeam laser to ablate them singly and in combination. We found that, in the absence of the larval muscle fibers, DLMs nonetheless develop. Our results show that the persistent larval muscle fibers are not required to initiate myoblast fusion, to determine DLM identity, to locate the DLMs in the thorax, or to specify the total DLM fiber volume. However, they are required to regulate the number of DLM fibers generated. Thus, while the persistent larval muscle fibers are not obligatory for DLM fiber formation and differentiation, they are necessary to ensure the development of the correct number of fibers.

Development of a New Class of Drugs to Inhibit All Forms of Androgen Receptor in Castration-Resistant Prostate Cancers

DTIC Science & Technology

2015-10-01

Prostate Cancers PRINCIPAL INVESTIGATORS: Scott Dehm CONTRACTING ORGANIZATION: University of Minnesota Minneapolis, MN 55455 REPORT DATE: October...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Regents of the University of Minnesota Office of...for pharmacological development b. Accomplishments under these goals: Major Activities for University of Minnesota Site (Dehm, PI) In the

Non-Profit Ecological Organizations in the Function of the Realization of the Right to Freedom of Association and the Development of Civil Environmental Liability in Kazakhstan

ERIC Educational Resources Information Center

Aitimov, Bolat Zh.; Dussipov, Erkin Sh.; Altynbekkyzy, Alua; Ashimova, Dinara I.; Nurbek, Dana T.; Urazymbetov, Talgat E.

2016-01-01

Environmental issues have become a central issue, which is considered not only at the state level, but also in the international arena. At the moment the main initiators of drawing attention to the environment are the environmental non-profit organizations. In developed countries, these organizations provide full support to the government and…

The Effect of an Advanced Organizer and the Predictive Ability of Micro-Learning Tasks When Utilized with Carefully Sequenced Audio-Tutorial Units.

ERIC Educational Resources Information Center

Kahle, Jane Butler

Four audio-tutorial units were developed as part of this study to determine the effectiveness of the use of advanced organizers, based on Ausubel's theories, for meaningful learning experiences. In this study an advanced organizer was developed and given to half of the subjects prior to the instructional sequence. A series of micro-learning tasks,…

ARABIDOPSIS THALIANA HOMEOBOX GENE1 establishes the basal boundaries of shoot organs and controls stem growth.

PubMed

Gómez-Mena, Concepción; Sablowski, Robert

2008-08-01

Apical meristems play a central role in plant development. Self-renewing cells in the central region of the shoot meristem replenish the cell population in the peripheral region, where organ primordia emerge in a predictable pattern, and in the underlying rib meristem, where new stem tissue is formed. While much is known about how organ primordia are initiated and their lateral boundaries established, development at the interface between the stem and the meristem or the lateral organs is poorly understood. Here, we show that the BELL-type ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1) is required for proper development of the boundary between the stem and both vegetative and reproductive organs and that this role partially overlaps with that of CUP-SHAPED COTYLEDON genes. During the vegetative phase, ATH1 also functions redundantly with light-activated genes to inhibit growth of the region below the shoot meristem. Consistent with a role in inhibiting stem growth, ATH1 is downregulated at the start of inflorescence development and ectopic ATH1 expression prevents growth of the inflorescence stem by reducing cell proliferation. Thus, ATH1 modulates growth at the interface between the stem, meristem, and organ primordia and contributes to the compressed vegetative habit of Arabidopsis thaliana.

Organ-on-a-Chip Technology for Reproducing Multiorgan Physiology.

PubMed

Lee, Seung Hwan; Sung, Jong Hwan

2018-01-01

In the drug development process, the accurate prediction of drug efficacy and toxicity is important in order to reduce the cost, labor, and effort involved. For this purpose, conventional 2D cell culture models are used in the early phase of drug development. However, the differences between the in vitro and the in vivo systems have caused the failure of drugs in the later phase of the drug-development process. Therefore, there is a need for a novel in vitro model system that can provide accurate information for evaluating the drug efficacy and toxicity through a closer recapitulation of the in vivo system. Recently, the idea of using microtechnology for mimicking the microscale tissue environment has become widespread, leading to the development of "organ-on-a-chip." Furthermore, the system is further developed for realizing a multiorgan model for mimicking interactions between multiple organs. These advancements are still ongoing and are aimed at ultimately developing "body-on-a-chip" or "human-on-a-chip" devices for predicting the response of the whole body. This review summarizes recently developed organ-on-a-chip technologies, and their applications for reproducing multiorgan functions. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Liquid Organic Fertilizers for Sustainable Agriculture: Nutrient Uptake of Organic versus Mineral Fertilizers in Citrus Trees

PubMed Central

Martínez-Alcántara, Belén; Martínez-Cuenca, Mary-Rus; Bermejo, Almudena; Legaz, Francisco; Quiñones, Ana

2016-01-01

The main objective of this study was to compare the performance of two liquid organic fertilizers, an animal and a plant-based fertilizer, with mineral fertilization on citrus trees. The source of the fertilizer (mineral or organic) had significant effect in the nutritional status of the organic and conventionally managed mandarins. Nutrient uptake, vegetative growth, carbohydrate synthesis and soil characteristics were analyzed. Results showed that plants fertilized with animal based liquid fertilizers exhibited higher total biomass with a more profuse development of new developing organs (leaves and fibrous roots). Liquid organic fertilization resulted in an increased uptake of macro and micronutrients compared to mineral fertilized trees. Moreover, organic fertilization positively affected the carbohydrate content (fructose, glucose and sucrose) mainly in summer flush leaves. Liquid organic fertilization also resulted in an increase of soil organic matter content. Animal-based fertilizer, due to intrinsic composition, increased total tree biomass and carbohydrate leaves content, and led to lower soil nitrate concentration and higher P and Mg exchangeable in soil extract compared to vegetal-based fertilizer. Therefore, liquid organic fertilizers could be used as an alternative to traditional mineral fertilization in drip irrigated citrus trees. PMID:27764099

Liquid Organic Fertilizers for Sustainable Agriculture: Nutrient Uptake of Organic versus Mineral Fertilizers in Citrus Trees.

PubMed

Martínez-Alcántara, Belén; Martínez-Cuenca, Mary-Rus; Bermejo, Almudena; Legaz, Francisco; Quiñones, Ana

2016-01-01

The main objective of this study was to compare the performance of two liquid organic fertilizers, an animal and a plant-based fertilizer, with mineral fertilization on citrus trees. The source of the fertilizer (mineral or organic) had significant effect in the nutritional status of the organic and conventionally managed mandarins. Nutrient uptake, vegetative growth, carbohydrate synthesis and soil characteristics were analyzed. Results showed that plants fertilized with animal based liquid fertilizers exhibited higher total biomass with a more profuse development of new developing organs (leaves and fibrous roots). Liquid organic fertilization resulted in an increased uptake of macro and micronutrients compared to mineral fertilized trees. Moreover, organic fertilization positively affected the carbohydrate content (fructose, glucose and sucrose) mainly in summer flush leaves. Liquid organic fertilization also resulted in an increase of soil organic matter content. Animal-based fertilizer, due to intrinsic composition, increased total tree biomass and carbohydrate leaves content, and led to lower soil nitrate concentration and higher P and Mg exchangeable in soil extract compared to vegetal-based fertilizer. Therefore, liquid organic fertilizers could be used as an alternative to traditional mineral fertilization in drip irrigated citrus trees.

Physiologically relevant organs on chips

PubMed Central

Yum, Kyungsuk; Hong, Soon Gweon; Lee, Luke P.

2015-01-01

Recent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or organs on chips, that reconstitute the physiologically critical features of specific human tissues and organs and their interactions. This technology uses microengineering approaches to construct organ-specific microenvironments, reconstituting tissue structures, tissue–tissue interactions and interfaces, and dynamic mechanical and biochemical stimuli found in specific organs, to direct cells to assemble into functional tissues. We first discuss microengineering approaches to reproduce the key elements of physiologically important, dynamic mechanical microenvironments, biochemical microenvironments, and microarchitectures of specific tissues and organs in microfluidic cell culture systems. This is followed by examples of microengineered individual organ models that incorporate the key elements of physiological microenvironments into single microfluidic cell culture systems to reproduce organ-level functions. Finally, microengineered multiple organ systems that simulate multiple organ interactions to better represent human physiology, including human responses to drugs, is covered in this review. This emerging organs-on-chips technology has the potential to become an alternative to 2D and 3D cell culture and animal models for experimental medicine, human disease modeling, drug development, and toxicology. PMID:24357624

Immune responses to bioengineered organs

PubMed Central

Ochando, Jordi; Charron, Dominique; Baptista, Pedro M.; Uygun, Basak E.

2017-01-01

Purpose of review Organ donation in the United States registered 9079 deceased organ donors in 2015. This high percentage of donations allowed organ transplantation in 29 851 recipients. Despite increasing numbers of transplants performed in comparison with previous years, the numbers of patients that are in need for a transplant increase every year at a higher rate. This reveals that the discrepancy between the demand and availability of organs remains fundamental problem in organ transplantation. Recent findings Development of bioengineered organs represents a promising approach to increase the pool of organs for transplantation. The technology involves obtaining complex three-dimensional scaffolds that support cellular activity and functional remodeling though tissue recellularization protocols using progenitor cells. This innovative approach integrates cross-thematic approaches from specific areas of transplant immunology, tissue engineering and stem cell biology, to potentially manufacture an unlimited source of donor organs for transplantation. Summary Although bioengineered organs are thought to escape immune recognition, the potential immune reactivity toward each of its components has not been studied in detail. Here, we summarize the host immune response toward different progenitor cells and discuss the potential implications of using nonself biological scaffolds to develop bioengineered organs. PMID:27926545

FRAMEWORK FOR THE INTEGRATION OF HEALTH AND ECOLOIGCAL RISK ASSESSMENT

EPA Science Inventory

The World Health Organization's International Programme on Chemical Safety (IPCS), the Organization for Economic Cooperation and Development (OECD), and the U.S. Environmental Protection Agency have developed a collaborative partnership to foster integration; of assessment approa...

10 CFR 1.39 - Office of Human Resources.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., programs, and services to provide for the effective organization, utilization, and development of the... NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Staff Offices... employees; and (f) Provides executive resources management and organizational and managerial development...

10 CFR 1.39 - Office of Human Resources.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., programs, and services to provide for the effective organization, utilization, and development of the... NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Staff Offices... employees; and (f) Provides executive resources management and organizational and managerial development...

42 CFR 121.6 - Organ procurement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... laboratory tests and clinical examinations of potential organ donors are performed to determine any... 42 Public Health 1 2010-10-01 2010-10-01 false Organ procurement. 121.6 Section 121.6 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH RESOURCES DEVELOPMENT ORGAN...

Legal briefing: organ donation and allocation.

PubMed

Pope, Thaddeus Mason

2010-01-01

This issue's "Legal Briefing" column covers legal developments pertaining to organ donation and allocation. This topic has been the subject of recent articles in JCE. Organ donation and allocation have also recently been the subjects of significant public policy attention. In the past several months, legislatures and regulatory agencies across the United States and across the world have changed, or considered changing, the methods for procuring and distributing human organs for transplantation. Currently, in the U.S., more than 100,000 persons are waiting for organ transplantation. In China, more than 1.5 million people are waiting. Given the chronic shortage of available organs (especially kidneys and livers) relative to demand, the primary focus of most legal developments has been on increasing the rate of donation. These and related developments are usefully divided into the following 12 topical categories: 1. Revised Uniform Anatomical Gift Act. 2. Presumed Consent and Opt-Out. 3. Mandated Choice. 4. Donation after Cardiac Death. 5. Payment and Compensation. 6. Donation by Prisoners. 7. Donor Registries. 8. Public Education. 9. Other Procurement Initiatives. 10. Lawsuits and Liability. 11. Trafficking and Tourism. 12. Allocation and Distribution.

Technical Excellence and Communication: The Cornerstones for Successful Safety and Mission Assurance Programs

NASA Technical Reports Server (NTRS)

Malone, Roy W.; Livingston, John M.

2010-01-01

The paper describes the role of technical excellence and communication in the development and maintenance of safety and mission assurance programs. The Marshall Space Flight Center (MSFC) Safety and Mission Assurance (S&MA) organization is used to illustrate philosophies and techniques that strengthen safety and mission assurance efforts and that contribute to healthy and effective organizational cultures. The events and conditions leading to the development of the MSFC S&MA organization are reviewed. Historic issues and concerns are identified. The adverse effects of resource limitations and risk assessment roles are discussed. The structure and functions of the core safety, reliability, and quality assurance functions are presented. The current organization s mission and vision commitments serve as the starting points for the description of the current organization. The goals and objectives are presented that address the criticisms of the predecessor organizations. Additional improvements are presented that address the development of technical excellence and the steps taken to improve communication within the Center, with program customers, and with other Agency S&MA organizations.

Peculiarities of the Inflammatory Process in the Reproductive Organs of C57Bl/6 Female Mice with Experimental Tuberculosis.

PubMed

Sukhikh, G T; Kayukova, S I; Bocharova, I V; Donnikov, A E; Lepekha, L N; Demikhova, O V; Uvarova, E V; Berezovskii, Yu S; Smirnova, T G

2016-04-01

Intravenous infection of C57Bl/6 female mice with M. tuberculosis H37Rv led to involvement of the lungs and dissemination of the tuberculous infection to the abdominal and pelvic organs. M. tuberculosis were detected in the lungs and spleen in 14, 35, and 90 days and in the uterine horns in 90 days after infection. Morphological analysis of organs showed successive development of exudative necrotic tuberculosis of the lungs, acute and chronic nonspecific inflammation in the reproductive organs (vagina, uterus, and uterine horns). The inflammatory process in the reproductive organs was associated with the development of anaerobic dysbiosis, that was most pronounced in 35 days after infection. Antituberculous therapy was followed by reduction of M. tuberculosis count in the lungs and spleen in 60 and 90 days after infection, eliminatation of M. tuberculosis in the uterine horns, arrest of nonspecific inflammation in female reproductive organs, recovery of the balance between aerobic and anaerobic microflora, and development of candidiasis of the urogenital mucosa.

Small molecule organic semiconductors on the move: promises for future solar energy technology.

PubMed

Mishra, Amaresh; Bäuerle, Peter

2012-02-27

This article is written from an organic chemist's point of view and provides an up-to-date review about organic solar cells based on small molecules or oligomers as absorbers and in detail deals with devices that incorporate planar-heterojunctions (PHJ) and bulk heterojunctions (BHJ) between a donor (p-type semiconductor) and an acceptor (n-type semiconductor) material. The article pays particular attention to the design and development of molecular materials and their performance in corresponding devices. In recent years, a substantial amount of both, academic and industrial research, has been directed towards organic solar cells, in an effort to develop new materials and to improve their tunability, processability, power conversion efficiency, and stability. On the eve of commercialization of organic solar cells, this review provides an overview over efficiencies attained with small molecules/oligomers in OSCs and reflects materials and device concepts developed over the last decade. Approaches to enhancing the efficiency of organic solar cells are analyzed. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Overview and Highlights of WOLEDs and Organic Solar Cells: From Research to Applications

NASA Astrophysics Data System (ADS)

Chan, Maggie Mei-Yee; Tao, Chi-Hang; Yam, Vivian Wing-Wah

Solid-state organic devices are at the vanguard of new generation of electronic components owing to their promise to be easily manufactured onto flexible substrates that potentially reduce the mass production cost for large modules. With the great efforts on improving the power efficiency that meets the realistic requirements for commercial applications, white organic light-emitting devices (WOLEDs) and organic solar cells have attracted much attention over the past two decades and are targeted as the effective ways for reducing the energy consumption and developing renewable energy in the world. Because of their great potentials to generate tremendous savings in both cost and energy usage, WOLEDs are considered as new generations of solid-state lighting sources to replace the incandescent bulbs, while organic solar cells are the most promising candidates to complement the inorganic silicon solar cells for electricity generation. Here, we will provide a survey on the recent developments of WOLEDs and organic solar cells and their current status in these fields. Resistances and hampers to the widespread acceptances of these two areas of developments are also discussed.

Measuring the electron affinity of organic solids: an indispensable new tool for organic electronics.

PubMed

Yoshida, Hiroyuki

2014-04-01

Electron affinity is a fundamental energy parameter of materials. In organic semiconductors, the electron affinity is closely related to electron conduction. It is not only important to understand fundamental electronic processes in organic solids, but it is also indispensable for research and development of organic semiconductor devices such as organic light-emitting diodes and organic photovoltaic cells. However, there has been no experimental technique for examining the electron affinity of organic materials that meets the requirements of such research. Recently, a new method, called low-energy inverse-photoemission spectroscopy, has been developed. A beam of low-energy electrons is focused onto the sample surface, and photons emitted owing to the radiative transition to unoccupied states are then detected. From the onset of the spectral intensity, the electron affinity is determined within an uncertainty of 0.1 eV. Unlike in conventional inverse-photoemission spectroscopy, sample damage is negligible and the resolution is improved by a factor of 2. The principle of the method and several applications are reported.

The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs.

PubMed

Feng, Wanyou; Dai, Yifan; Mou, Lisha; Cooper, David K C; Shi, Deshun; Cai, Zhiming

2015-03-23

Clinical organ allotransplantation is limited by the availability of deceased human donors. However, the transplantation of human organs produced in other species would provide an unlimited number of organs. The pig has been identified as the most suitable source of organs for humans as organs of any size would be available. Genome editing by RNA-guided endonucleases, also known as clustered regularly interspaced short palindromic repeat (CRISPR/Cas9), in combination with induced pluripotent stem cells (iPSC), may have the potential to enable the creation of human organs from genetically-modified chimaeric pigs. These could potentially provide an unlimited supply of organs that would not be rejected by the recipient's immune system. However, substantial research is needed to prove that this approach will work. Genetic modification of chimaeric pigs could also provide useful models for developing therapies for various human diseases, especially in relation to drug development.

Community organizing goes to college: a practice-based model to implement environmental strategies to reduce high-risk drinking on college campuses.

PubMed

Wagoner, Kimberly G; Rhodes, Scott D; Lentz, Ashley W; Wolfson, Mark

2010-11-01

Community organizing is a successful method to leverage resources and build community capacity to identify and intervene on health issues. However, published accounts documenting the systematic facilitation of the process are limited. This qualitative analysis explored community organizing using data collected as part of the Study to Prevent Alcohol Related Consequences (SPARC), a randomized community trial of 10 North Carolina colleges focused on reducing consequences of high-risk drinking among college students. The authors sought to develop and confirm use of a community-organizing model, based in practice, illustrating an authentic process of organizing campus and community stakeholders for public health change. Using the grounded theory approach, they analyzed and interpreted data from three waves of individual interviews with full-time community organizers on five SPARC intervention campuses. A five-phase community-organizing model was developed and its use was confirmed. This model may serve as a practical guide for public health interventions using community-organizing approaches.

Developing neuronal networks: Self-organized criticality predicts the future

NASA Astrophysics Data System (ADS)

Pu, Jiangbo; Gong, Hui; Li, Xiangning; Luo, Qingming

2013-01-01

Self-organized criticality emerged in neural activity is one of the key concepts to describe the formation and the function of developing neuronal networks. The relationship between critical dynamics and neural development is both theoretically and experimentally appealing. However, whereas it is well-known that cortical networks exhibit a rich repertoire of activity patterns at different stages during in vitro maturation, dynamical activity patterns through the entire neural development still remains unclear. Here we show that a series of metastable network states emerged in the developing and ``aging'' process of hippocampal networks cultured from dissociated rat neurons. The unidirectional sequence of state transitions could be only observed in networks showing power-law scaling of distributed neuronal avalanches. Our data suggest that self-organized criticality may guide spontaneous activity into a sequential succession of homeostatically-regulated transient patterns during development, which may help to predict the tendency of neural development at early ages in the future.

Appendix: Case Studies. Strong Neighborhoods, Strong Schools. The Indicators Project on Education Organizing.

ERIC Educational Resources Information Center

Gold, Eva; Simon, Elaine; Brown, Chris; Blanc, Suzanne; Pickron-Davis, Marcine; Brown, Joanna; Navarez-La Torre, Aida

This report presents summaries of five case studies from the Indicators Project on Education Organizing, which was designed to examine the role of community organizing in school reform. For over 2 years, this action research project documented the education organizing of five urban groups. The research developed an Education Organizing Indicators…

The role of ventral and preventral organs as attachment sites for segmental limb muscles in Onychophora

PubMed Central

2013-01-01

Background The so-called ventral organs are amongst the most enigmatic structures in Onychophora (velvet worms). They were described as segmental, ectodermal thickenings in the onychophoran embryo, but the same term has also been applied to mid-ventral, cuticular structures in adults, although the relationship between the embryonic and adult ventral organs is controversial. In the embryo, these structures have been regarded as anlagen of segmental ganglia, but recent studies suggest that they are not associated with neural development. Hence, their function remains obscure. Moreover, their relationship to the anteriorly located preventral organs, described from several onychophoran species, is also unclear. To clarify these issues, we studied the anatomy and development of the ventral and preventral organs in several species of Onychophora. Results Our anatomical data, based on histology, and light, confocal and scanning electron microscopy in five species of Peripatidae and three species of Peripatopsidae, revealed that the ventral and preventral organs are present in all species studied. These structures are covered externally with cuticle that forms an internal, longitudinal, apodeme-like ridge. Moreover, phalloidin-rhodamine labelling for f-actin revealed that the anterior and posterior limb depressor muscles in each trunk and the slime papilla segment attach to the preventral and ventral organs, respectively. During embryonic development, the ventral and preventral organs arise as large segmental, paired ectodermal thickenings that decrease in size and are subdivided into the smaller, anterior anlagen of the preventral organs and the larger, posterior anlagen of the ventral organs, both of which persist as paired, medially-fused structures in adults. Our expression data of the genes Delta and Notch from embryos of Euperipatoides rowelli revealed that these genes are expressed in two, paired domains in each body segment, corresponding in number, position and size with the anlagen of the ventral and preventral organs. Conclusions Our findings suggest that the ventral and preventral organs are a common feature of onychophorans that serve as attachment sites for segmental limb depressor muscles. The origin of these structures can be traced back in the embryo as latero-ventral segmental, ectodermal thickenings, previously suggested to be associated with the development of the nervous system. PMID:24308783

Knowledge brokering between researchers and policymakers in Fiji to develop policies to reduce obesity: a process evaluation.

PubMed

Waqa, Gade; Mavoa, Helen; Snowdon, Wendy; Moodie, Marj; Schultz, Jimaima; McCabe, Marita; Kremer, Peter; Swinburn, Boyd

2013-07-01

The importance of using research evidence in decisionmaking at the policy level has been increasingly recognized. However, knowledge brokering to engage researchers and policymakers in government and non-government organizations is challenging. This paper describes and evaluates the knowledge exchange processes employed by the Translational Research on Obesity Prevention in Communities (TROPIC) project that was conducted from July 2009 to April 2012 in Fiji. TROPIC aimed to enhance: the evidence-informed decisionmaking skills of policy developers; and awareness and utilization of local and other obesity-related evidence to develop policies that could potentially improve the nation's food and physical activity environments. The specific research question was: Can a knowledge brokering approach advance evidence-informed policy development to improve eating and physical activity environments in Fiji. The intervention comprised: recruiting organizations and individuals; mapping policy environments; analyzing organizational capacity and support for evidence-informed policymaking (EIPM); developing EIPM skills; and facilitating development of evidence-informed policy briefs. Flexible timetabling of activities was essential to accommodate multiple competing priorities at both individual and organizational levels. Process diaries captured the duration, frequency and type of each interaction and/or activity between the knowledge brokering team and participants or their organizations. Partnerships were formalized with high-level officers in each of the six participating organization. Participants (n = 49) developed EIPM skills (acquire, assess, adapt and apply evidence) through a series of four workshops and applied this knowledge to formulate briefs with ongoing one-to-one support from TROPIC team members. A total of 55% of participants completed the 12 to18 month intervention, and 63% produced one or more briefs (total = 20) that were presented to higher-level officers within their organizations. The knowledge brokering team spent an average of 30 hours per participant during the entire TROPIC process. Active engagement of participating organizations from the outset resulted in strong individual and organizational commitment to the project. The TROPIC initiative provided a win-win situation, with participants expanding skills in EIPM and policy development, organizations increasing EIPM capacity, and researchers providing data to inform policy.

Knowledge brokering between researchers and policymakers in Fiji to develop policies to reduce obesity: a process evaluation

PubMed Central

2013-01-01

Background The importance of using research evidence in decisionmaking at the policy level has been increasingly recognized. However, knowledge brokering to engage researchers and policymakers in government and non-government organizations is challenging. This paper describes and evaluates the knowledge exchange processes employed by the Translational Research on Obesity Prevention in Communities (TROPIC) project that was conducted from July 2009 to April 2012 in Fiji. TROPIC aimed to enhance: the evidence-informed decisionmaking skills of policy developers; and awareness and utilization of local and other obesity-related evidence to develop policies that could potentially improve the nation’s food and physical activity environments. The specific research question was: Can a knowledge brokering approach advance evidence-informed policy development to improve eating and physical activity environments in Fiji. Methods The intervention comprised: recruiting organizations and individuals; mapping policy environments; analyzing organizational capacity and support for evidence-informed policymaking (EIPM); developing EIPM skills; and facilitating development of evidence-informed policy briefs. Flexible timetabling of activities was essential to accommodate multiple competing priorities at both individual and organizational levels. Process diaries captured the duration, frequency and type of each interaction and/or activity between the knowledge brokering team and participants or their organizations. Results Partnerships were formalized with high-level officers in each of the six participating organization. Participants (n = 49) developed EIPM skills (acquire, assess, adapt and apply evidence) through a series of four workshops and applied this knowledge to formulate briefs with ongoing one-to-one support from TROPIC team members. A total of 55% of participants completed the 12 to18 month intervention, and 63% produced one or more briefs (total = 20) that were presented to higher-level officers within their organizations. The knowledge brokering team spent an average of 30 hours per participant during the entire TROPIC process. Conclusions Active engagement of participating organizations from the outset resulted in strong individual and organizational commitment to the project. The TROPIC initiative provided a win-win situation, with participants expanding skills in EIPM and policy development, organizations increasing EIPM capacity, and researchers providing data to inform policy. PMID:23816188

Growing Up: The Development of Psychosocial Maturity. Report No. 180.

ERIC Educational Resources Information Center

Greenberger, Ellen; And Others

The Center for Social Organization of Schools has two objectives: to develop a scientific knowledge of how schools affect their students, and to use this knowledge to develop better school practices and organization. One of the three programs sponsored by the center is the Schools and Maturity Program. It is studying the effects of school, family,…

National Skills Standards Development Project. Study of the State of the Art of Certification and Accreditation Programs.

ERIC Educational Resources Information Center

Electronic Industries Foundation, Washington, DC.

A study of 10 organizations explored how their various certification or accreditation programs were developed, structured, and managed and made observations to guide the development of certification or accreditation for the electronics industry. From November 1994 through January 1995, a phone and fax survey was conducted of these organizations:…

Control, Control, Complete Control!!! Neurotic Control Relationships and the Development of Dysfunctional Organizational Structures.

ERIC Educational Resources Information Center

Kersten, Astrid

A case study illustrates the concept of the neurotic organization by describing the development of "Central Control College" over a period of 11 years. In this period of time, the college moved from a small, informal organization to a highly developed compulsive institution. The image of neurosis has been applied in the organizational…

Why Is Organizing Human Resource Development so Problematic? Perspectives from the Learning-Network Theory (Part I)

ERIC Educational Resources Information Center

Poell, Rob F.; van der Krogt, Ferd

2017-01-01

Purpose: Human resource development (HRD) is an important field within management. Developing employees is often regarded as an instrument to improve the internal labor market and support organizational change. Organizing HRD to these ends, however, is frequently a problematic affair, in terms of training effectiveness, participant motivation and…

Why is Organizing Human Resource Development so Problematic? Perspectives from the Learning-Network Theory (Part II)

ERIC Educational Resources Information Center

Poell, Rob F.; Van Der Krogt, Ferd

2017-01-01

Purpose: Human resource development (HRD) is an important field within management. Developing employees is often regarded as an instrument to improve the internal labor market and support organizational change. Organizing HRD to these ends, however, is frequently a problematic affair, in terms of training effectiveness, participant motivation and…

Recent Developments in Polymeric Charge Transfer Complexes

DTIC Science & Technology

1994-03-01

systems using dies on nematic phases of polymers involhing p- the Langmuir Blodgett procedure to obtain multi- chiloranil as the acceptor molecule [8...excluded. These applications are: compatibilization of polymer blends, liquid crystalline supramolecular organization, new develoments in...polymner blends, liquid crystalline supra- technological developments. Finally, I will cover in nmlecular organization, ne,’, developments in photo- some

Building Social Change Oriented Leadership Capacity Among Student Organizations: Developing Students and Campuses Simultaneously.

PubMed

Kezar, Adrianna; Acuña Avilez, Arely; Drivalas, Yianna; Wheaton, Marissiko M

2017-09-01

This chapter highlights nontraditional forms of leadership development in student organizations. Using the social change model for leadership as a framework, the authors discuss the ways in which collectivist and activist approaches can result in similar skills obtained through traditional forms of leadership development. © 2017 Wiley Periodicals, Inc., A Wiley Company.

Determinants of the Satisfaction of Firms with the Competencies of University Students: A Spanish Case Study

ERIC Educational Resources Information Center

Marzo-Navarro, Mercedes; Pedraja-Iglesias, Marta; Rivera-Torres, Pilar

2008-01-01

In recognition of its increasing importance, many organizations make periodic assessments of their training and development activity. The objective of the present study was to extend the concept of capacity building to the assessment of training and development activity in an automobile component manufacturing organization, using a developed and…

ADULT EDUCATION TECHNIQUES IN DEVELOPING COUNTRIES, A GREEK CASE STUDY. PROBLEMS OF DEVELOPMENT SERIES.

ERIC Educational Resources Information Center

FOURRE, PIERRE; AND OTHERS

AIDED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT AND THE ORGANIZATION FOR EUROPEAN ECONOMIC COOPERATION, GREECE HAS ESTABLISHED A NETWORK OF ADULT EDUCATION CENTERS OUTSIDE TOWNS, TO MEET THE PROBLEMS OF ILLITERACY AND LOW EDUCATION LEVEL. THE CENTER PROVIDES FOR ACADEMIC AND LIBRARY PROGRAMS, SIX TO SEVEN MONTHS, AND RECREATION…

Evaluation of Knowledge Development in a Healthcare Setting

NASA Astrophysics Data System (ADS)

Schaffer, Scott P.

Healthcare organizations worldwide have recently increased efforts to improve performance, quality, and knowledge transfer using information and communication technologies. Evaluation of the effectiveness and quality of such efforts is challenging. A macro and micro-level system evaluation conducted with a 14000 member US hospital administrative services organization examined the appropriateness of a blended face-to-face and technology-enabled performance improvement and knowledge development system. Furthermore, a successful team or microsystem in a high performing hospital was studied in-depth. Several types of data methods including interview, observation, and questionnaire were used to address evaluation questions within a knowledge development framework created for the study. Results of this preliminary study focus on how this organization attempted to organize clinical improvement efforts around quality and performance improvement processes supported by networked technologies.

Developing talent for operational excellence.

PubMed

Theadore, Jason C; O'Brien, Thaddeus J

2012-01-01

Many organizations have the expectation that their employees will prepare for their own professional development without much support or guidance. To achieve operational excellence, development of the people in an organization is just as important as the development of technologies and processes. Ohio Health Ambulatory Division in Columbus, OH created a plan to develop its people systematically in three distinct pillars: management development, staff engagement, and clinical excellence. Much was learned about talent development since work began on "The People Plan", perhaps the most critical lesson learned has been the importance of not giving up on the effort.

Tissue bioengineering and artificial organs.

PubMed

Llames, Sara; García, Eva; Otero Hernández, Jesús; Meana, Alvaro

2012-01-01

The scarcity of organs and tissues for transplant and the need of immunosuppressive drugs to avoid rejection constitute two reasons that justify organ and tissue production in the laboratory. Tissue engineering based tissues (TE) could allow to regenerate the whole organ from a fragment or even to produce several organs from an organ donor for grafting purposes. TE is based in: (1) the ex vivo expansion of cells, (2) the seeding of these expanded cells in tridimensional structures that mimic physiological conditions and, (3) grafting the prototype. In order to graft big structures it is necessary that the organ or tissue produced "ex vivo" bears a vascular tree to ensure the nutrition of its deep layers. At present, no technology has been developed to provide this vascular tree to TE derived products. Thus, these tissues must be thin enough to acquire nutrients during the first days by diffusion from surrounding tissues. This fact constitutes nowadays the greatest limitation of technologies for organ development in the laboratory.In this chapter, all these problems and their possible solutions are commented. Also, the present status of TE techniques in the regeneration of different organ systems is reviewed.

Organogenesis in plants: initiation and elaboration of leaves

USDA-ARS?s Scientific Manuscript database

Plant organs initiate from meristems and grow into diverse forms. After initiation, organs enter a morphological phase where they develop their shape, followed by differentiation into mature tissue. Investigations into these processes have revealed numerous factors necessary for proper development, ...

"High Stage" Organizing.

ERIC Educational Resources Information Center

Torbert, William R.

Although a psychological theory of stages of transformation in human development currently exists, organizational researchers have yet to elaborate and test any theory of organizational transformation of comparable elegance. According to the organizational stage theory being developed since 1974 by William Torbert, bureaucratic organization, which…

Molecular Mechanisms of Inner Ear Development

PubMed Central

Wu, Doris K.; Kelley, Matthew W.

2012-01-01

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Hence, the study of inner ear development provides a rich context for understanding the functions of genes implicated in hearing loss. This chapter focuses on molecular mechanisms of inner ear development derived from studies of model organisms. PMID:22855724

Collagen in organ development

NASA Technical Reports Server (NTRS)

Hardman, P.; Spooner, B. S.

1992-01-01

It is important to know whether microgravity will adversely affect developmental processes. Collagens are macromolecular structural components of the extracellular matrix (ECM) which may be altered by perturbations in gravity. Interstitial collagens have been shown to be necessary for normal growth and morphogenesis in some embryonic organs, and in the mouse salivary gland, the biosynthetic pattern of these molecules changes during development. Determination of the effects of microgravity on epithelial organ development must be preceded by crucial ground-based studies. These will define control of normal synthesis, secretion, and deposition of ECM macromolecules and the relationship of these processes to morphogenesis.

Operationalizing Sustainable Development Suncor Energy Inc: A critical case

NASA Astrophysics Data System (ADS)

Fergus, Andrew

The concept of Sustainable Development is often understood as a framework within which organizations are able to move forward in a successful and beneficial manner. However, it is also seen as an ambiguous notion with little substance beyond a hopeful dialogue. If we are to base organizational action upon the concepts of Sustainable Development, it is vital that we comprehend the implications of how the concept is understood at a behavioral level. Industry leaders, competitors, shareholders, and stakeholders recognize Suncor Energy Inc as a leading organization within the Oil and Gas energy field. In particular it has a reputation for proactive thinking and action within the areas of environmental and social responsibility. Through attempting to integrate the ideas of Sustainable Development at a foundational level into the strategic plan, the management of Suncor Energy Inc has committed the organization to be a sustainable energy company. To achieve this vision the organization faces the challenge of converting strategic goals into operational behaviors, a process critical for a successful future. This research focuses on understanding the issues found with this conversion process. Through exploring a critical case, this research illuminates the reality of a best-case scenario. The findings thus have implications for both Suncor Energy Inc and more importantly all other organizations attempting to move in a Sustainable Development direction.

Transcriptional Analysis of Tendril and Inflorescence Development in Grapevine (Vitis vinifera L.)

PubMed Central

Díaz-Riquelme, José; Martínez-Zapater, José M.; Carmona, María J.

2014-01-01

In grapevine (Vitis vinifera L.), the lateral meristem can give rise to either tendrils or inflorescences which are determined organs. To get insights into the processes of tendril and inflorescence development, we characterized the transcriptional variation taking place in both organs. The results of the global transcriptional analyses along tendril and inflorescence development suggested that these two homologous organs initially share a common transcriptional program related to cell proliferation and growth functions. In later developmental stages they showed organ specific gene expression programs related to the particular differentiation processes taking place in each organ. In this way, tendrils showed higher transcription of genes related to photosynthesis, hormone signaling and secondary metabolism than inflorescences, while inflorescences displayed higher transcriptional activity for genes encoding transcription factors, mainly those belonging to the MADS-box gene family. The expression profiles of selected transcription factors related with inflorescence and flower meristem identity and with flower organogenesis were generally conserved with respect to their homologs in model species. Regarding tendrils, it was interesting to find that genes related with reproductive development in other species were also recruited for grapevine tendril development. These results suggest a role for those genes in the regulation of basic cellular mechanisms common to both developmental processes. PMID:24637773

78 FR 64520 - Statement of Organization, Functions, and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Statement of Organization... Organization, Functions, and Delegations of Authority for the Department of Health and Human Services (40 FR... Development (NICHD). Section N-T, Organization and Functions, under the heading Eunice Kennedy Shriver...

24 CFR 4100.2 - General organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false General organization. 4100.2... (Continued) NEIGHBORHOOD REINVESTMENT CORPORATION ORGANIZATION AND CHANNELING OF FUNCTIONS § 4100.2 General organization. (a) The Board of Directors. (1) The Corporation is under the direction of a Board of Directors...

Organic Chemistry Self Instructional Package 2: Methane.

ERIC Educational Resources Information Center

Zdravkovich, V.

This booklet, one of a series of 17 developed at Prince George's Community College, Largo, Maryland, provides an individualized, self-paced undergraduate organic chemistry instruction module designed to augment any course in organic chemistry but particularly those taught using the text "Organic Chemistry" by Morrison and Boyd. The…

77 FR 47854 - Proposed Information Collection Activity: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... Organizations, and Urban Indian Organizations. Competitive grants to non-profit organizations to provide home... consultation with evidence-based home visiting model developers and selected grantees and further refined based... addition to 56 jurisdictions and non-profit organizations, it is estimated that up to 25 Tribal MIECHV...

Supplemental fertilizers for organic greenhouse soil media

USDA-ARS?s Scientific Manuscript database

The consumer’s perceptions that organic food tastes better and is healthier are two major factors driving the increasing demand for organically produced crops in the U.S. It was necessary to develop organic certification to provide consistent standards across the U.S. for the benefit of producers, ...

Theory and Practice of Sustainable Development: Path to Managing Rural Grass-roots Party Organization from the Perspective of Impetus

NASA Astrophysics Data System (ADS)

Zhong, Xianzhe

2018-02-01

Impetus is the most fundamental guarantee for the survival and progress of organization. The rural grass-roots party organization should serve as a battle fortress of party helping realize the purpose of party in the village. Therefore, to strengthen the management of rural party branches, it is imperative to optimize their impetus, stepping on the basic paths: developing and utilizing material force, and digging and stimulating spiritual force for rural grass-roots party organization construction; adhering to the dialectical view on impetus to highlight both material and spiritual motivations.

Proximal sensing for soil carbon accounting

NASA Astrophysics Data System (ADS)

England, Jacqueline R.; Viscarra Rossel, Raphael A.

2018-05-01

Maintaining or increasing soil organic carbon (C) is vital for securing food production and for mitigating greenhouse gas (GHG) emissions, climate change, and land degradation. Some land management practices in cropping, grazing, horticultural, and mixed farming systems can be used to increase organic C in soil, but to assess their effectiveness, we need accurate and cost-efficient methods for measuring and monitoring the change. To determine the stock of organic C in soil, one requires measurements of soil organic C concentration, bulk density, and gravel content, but using conventional laboratory-based analytical methods is expensive. Our aim here is to review the current state of proximal sensing for the development of new soil C accounting methods for emissions reporting and in emissions reduction schemes. We evaluated sensing techniques in terms of their rapidity, cost, accuracy, safety, readiness, and their state of development. The most suitable method for measuring soil organic C concentrations appears to be visible-near-infrared (vis-NIR) spectroscopy and, for bulk density, active gamma-ray attenuation. Sensors for measuring gravel have not been developed, but an interim solution with rapid wet sieving and automated measurement appears useful. Field-deployable, multi-sensor systems are needed for cost-efficient soil C accounting. Proximal sensing can be used for soil organic C accounting, but the methods need to be standardized and procedural guidelines need to be developed to ensure proficient measurement and accurate reporting and verification. These are particularly important if the schemes use financial incentives for landholders to adopt management practices to sequester soil organic C. We list and discuss requirements for developing new soil C accounting methods based on proximal sensing, including requirements for recording, verification, and auditing.

Corrosion Finishing/Coating Systems for DoD Metallic Substrates Based on Non-Chromate Inhibitors and UV Curable, Zero VOC Materials

DTIC Science & Technology

2010-08-01

Corrosion resistant coatings containing non-chromate inhibitors and no volatile organic compounds were developed and evaluated for DoD applications...Transmission Electron Microscopy TRI – Toxic Release Inventory UV – Ultraviolet UVAs – Ultraviolet Absorbers VOCs – Volatile Organic Compounds XPS – X...containing non-chromate inhibitors and no volatile organic compounds were developed and evaluated for DoD applications. The technical effort

Developing Military Health Care Leaders: Insights from the Military, Civilian, and Government Sectors

DTIC Science & Technology

2011-01-01

6 mentoring, career counseling, feedback, and self- development . Organizations differ in terms of how much emphasis they place on particular...deliberate sample of health care organizations in the private sector that were most likely to offer lessons learned for DoD. Our interviews were conducted...the eight sampled organizations , for a total of eight interviews. VHA Case Study. In addition to the private - sector interviews, we examined public

Developing Governance for Federated Community-based EHR Data Sharing

PubMed Central

Lin, Ching-Ping; Stephens, Kari A.; Baldwin, Laura-Mae; Keppel, Gina A.; Whitener, Ron J.; Echo-Hawk, Abigail; Korngiebel, Diane

2014-01-01

Bi-directional translational pathways between scientific discoveries and primary care are crucial for improving individual patient care and population health. The Data QUEST pilot project is a program supporting data sharing amongst community based primary care practices and is built on a technical infrastructure to share electronic health record data. We developed a set of governance requirements from interviewing and collaborating with partner organizations. Recommendations from our partner organizations included: 1) partner organizations can physically terminate the link to the data sharing network and only approved data exits the local site; 2) partner organizations must approve or reject each query; 3) partner organizations and researchers must respect local processes, resource restrictions, and infrastructures; and 4) partner organizations can be seamlessly added and removed from any individual data sharing query or the entire network. PMID:25717404

Carbon and nitrogen isotopic signatures and nitrogen profile to identify adulteration in organic fertilizers.

PubMed

Verenitch, Sergei; Mazumder, Asit

2012-08-29

Recently it has been shown that stable isotopes of nitrogen can be used to discriminate between organic and synthetic fertilizers, but the robustness of the approach is questionable. This work developed a comprehensive method that is far more robust in identifying an adulteration of organic nitrogen fertilizers. Organic fertilizers of various types (manures, composts, blood meal, bone meal, fish meal, products of poultry and plant productions, molasses and seaweed based, and others) available on the North American market were analyzed to reveal the most sensitive criteria as well as their quantitative ranges, which can be used in their authentication. Organic nitrogen fertilizers of known origins with a wide δ(15)N range between -0.55 and 28.85‰ (n = 1258) were characterized for C and N content, δ(13)C, δ(15)N, viscosity, pH, and nitrogen profile (urea, ammonia, organic N, water insoluble N, and NO3). A statistically significant data set of characterized unique organic nitrogen fertilizers (n = 335) of various known origins has been assembled. Deliberately adulterated samples of different types of organic fertilizers mixed with synthetic fertilizers at a wide range of proportions have been used to develop the quantitative critical characteristics of organic fertilizers as the key indicators of their adulteration. Statistical analysis based on the discriminant functions of the quantitative critical characteristics of organic nitrogen fertilizers from 14 different source materials revealed a very high average rate of correct classification. The developed methodology has been successfully used as a source identification tool for numerous commercial nitrogen fertilizers available on the North American market.

Molecular characterization of the apical organ of the anthozoan Nematostella vectensis

PubMed Central

Sinigaglia, Chiara; Busengdal, Henriette; Lerner, Avi; Oliveri, Paola; Rentzsch, Fabian

2015-01-01

Apical organs are sensory structures present in many marine invertebrate larvae where they are considered to be involved in their settlement, metamorphosis and locomotion. In bilaterians they are characterised by a tuft of long cilia and receptor cells and they are associated with groups of neurons, but their relatively low morphological complexity and dispersed phylogenetic distribution have left their evolutionary relationship unresolved. Moreover, since apical organs are not present in the standard model organisms, their development and function are not well understood. To provide a foundation for a better understanding of this structure we have characterised the molecular composition of the apical organ of the sea anemone Nematostella vectensis. In a microarray-based comparison of the gene expression profiles of planulae with either a wildtype or an experimentally expanded apical organ, we identified 78 evolutionarily conserved genes, which are predominantly or specifically expressed in the apical organ of Nematostella. This gene set comprises signalling molecules, transcription factors, structural and metabolic genes. The majority of these genes, including several conserved, but previously uncharacterized ones, are potentially involved in different aspects of the development or function of the long cilia of the apical organ. To demonstrate the utility of this gene set for comparative analyses, we further analysed the expression of a subset of previously uncharacterized putative orthologs in sea urchin larvae and detected expression for twelve out of eighteen of them in the apical domain. Our study provides a molecular characterization of the apical organ of Nematostella and represents an informative tool for future studies addressing the development, function and evolutionary history of apical organ cells. PMID:25478911

Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype.

PubMed

Bhat, Ramray; Bissell, Mina J

2014-01-01

The study of biological form and how it arises is the domain of the developmental biologists; but once the form is achieved, the organ poses a fascinating conundrum for all the life scientists: how are form and function maintained in adult organs throughout most of the life of the organism? That they do appears to contradict the inherently plastic nature of organogenesis during development. How do cells with the same genetic information arrive at, and maintain such different architectures and functions, and how do they keep remembering that they are different from each other? It is now clear that narratives based solely on genes and an irreversible regulatory dynamics cannot answer these questions satisfactorily, and the concept of microenvironmental signaling needs to be added to the equation. During development, cells rearrange and differentiate in response to diffusive morphogens, juxtacrine signals and the extracellular matrix (ECM). These components, which constitute the modular microenvironment, are sensitive to cues from other tissues and organs of the developing embryo as well as from the external macroenvironment. On the other hand, once the organ is formed, these modular constituents integrate and constrain the organ architecture, which ensures structural and functional homeostasis and therefore, organ specificity. We argue here that a corollary of the above is that once the organ architecture is compromised in adults by mutations or by changes in the microenvironment such as aging or inflammation, that organ becomes subjected to the developmental and embryonic circuits in search of a new identity. But since the microenvironment is no longer embryonic, the confusion leads to cancer: hence as we have argued, tumors become new evolutionary organs perhaps in search of an elusive homeostasis.

Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype

PubMed Central

Bhat, Ramray; Bissell, Mina J.

2013-01-01

The study of biological form and how it arises is the domain of the developmental biologists; but once the form is achieved, the organ poses a fascinating conundrum for all the life scientists: how are form and function maintained in adult organs throughout most of the life of the organism? That they do appears to contradict the inherently plastic nature of organogenesis during development. How do cells with the same genetic information arrive at, and maintain such different architectures and functions, and how do they keep remembering that they are different from each other? It is now clear that narratives based solely on genes and an irreversible regulatory dynamics cannot answer these questions satisfactorily, and the concept of microenvironmental signaling needs to be added to the equation. During development, cells rearrange and differentiate in response to diffusive morphogens, juxtacrine signals and the extracellular matrix (ECM). These components, which constitute the modular microenvironment, are sensitive to cues from other tissues and organs of the developing embryo as well as from the external macroenvironment. On the other hand, once the organ is formed, these modular constituents integrate and constrain the organ architecture, which ensures structural and functional homeostasis and therefore, organ specificity. We argue here that a corollary of the above is that once the organ architecture is compromised in adults by mutations or by changes in the microenvironment such as aging or inflammation, that organ becomes subjected to the developmental and embryonic circuits in search of a new identity. But since the microenvironment is no longer embryonic, the confusion leads to cancer: hence as we have argued, tumors become new evolutionary organs perhaps in search of an elusive homeostasis. PMID:24678448

Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype.

PubMed

Bhat, Ramray; Bissell, Mina J

2014-01-01

The study of biological form and how it arises is the domain of the developmental biologists; but once the form is achieved, the organ poses a fascinating conundrum for all the life scientists: how are form and function maintained in adult organs throughout most of the life of the organism? That they do appears to contradict the inherently plastic nature of organogenesis during development. How do cells with the same genetic information arrive at, and maintain such different architectures and functions, and how do they keep remembering that they are different from each other? It is now clear that narratives based solely on genes and an irreversible regulatory dynamics cannot answer these questions satisfactorily, and the concept of microenvironmental signaling needs to be added to the equation. During development, cells rearrange and differentiate in response to diffusive morphogens, juxtacrine signals, and the extracellular matrix (ECM). These components, which constitute the modular microenvironment, are sensitive to cues from other tissues and organs of the developing embryo as well as from the external macroenvironment. On the other hand, once the organ is formed, these modular constituents integrate and constrain the organ architecture, which ensures structural and functional homeostasis and therefore, organ specificity. We argue here that a corollary of the above is that once the organ architecture is compromised in adults by mutations or by changes in the microenvironment such as aging or inflammation, that organ becomes subjected to the developmental and embryonic circuits in search of a new identity. But since the microenvironment is no longer embryonic, the confusion leads to cancer: hence as we have argued, tumors become new evolutionary organs perhaps in search of an elusive homeostasis. © 2013 Wiley Periodicals, Inc.

Using Academy Standards of Excellence in Nutrition and Dietetics for organization self-assessment and quality improvement.

PubMed

Price, Joyce A; Kent, Sue; Cox, Sharon A; McCauley, Sharon M; Parekh, Janki; Klein, Catherine J

2014-08-01

Standards of Excellence in Nutrition and Dietetics for an Organization is a self-assessment tool to measure and evaluate an organization's program, services, and initiatives that identify and distinguish the Registered Dietitian Nutritionist (RDN) brand as the professional expert in food and nutrition. The Standards of Excellence will serve as a road map to recognize RDNs as leaders and collaborators. Standards of Excellence criteria apply to all practice segments of nutrition and dietetics: health care, education and research, business and industry, and community nutrition and public health. Given the membership's call to action to be recognized for their professional expertise, the Academy of Nutrition and Dietetics Quality Management Committee developed four Standards of Excellence in Nutrition and Dietetics for Organizations: Quality of Leadership, Quality of Organization, Quality of Practice, and Quality of Outcomes. Within each standard, specific indicators provide strategies for an organization to demonstrate excellence. The Academy will develop a self-evaluation scoring tool to assist the organization in applying and implementing one or more of the strategies in the Standards of Excellence indicators. The organization can use the self-assessment tool to establish itself as a Center of Excellence in Nutrition and Dietetics. The role examples illustrate initiatives RDNs and organizations can take to identify themselves as a Center of Excellence in Nutrition and Dietetics. Achieving the Excellence level is an important collaborative initiative between nutrition and dietetics organizations and the Academy to provide increased autonomy, supportive management, respect within peers and community, opportunities for professional development, support for further education, and compensation for the RDN. For purposes of the Standards, "organization" means workplace or practice setting. Copyright © 2014 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds.

PubMed

Schantz, Michele M; Benner, Bruce A; Heckert, N Alan; Sander, Lane C; Sharpless, Katherine E; Vander Pol, Stacy S; Vasquez, Y; Villegas, M; Wise, Stephen A; Alwis, K Udeni; Blount, Benjamin C; Calafat, Antonia M; Li, Zheng; Silva, Manori J; Ye, Xiaoyun; Gaudreau, Éric; Patterson, Donald G; Sjödin, Andreas

2015-04-01

Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers' Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants.

Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds

PubMed Central

Schantz, Michele M.; Benner, Bruce A.; Heckert, N. Alan; Sander, Lane C.; Sharpless, Katherine E.; Vander Pol, Stacy S.; Vasquez, Y.; Villegas, M.; Wise, Stephen A.; Alwis, K. Udeni; Blount, Benjamin C.; Calafat, Antonia M.; Li, Zheng; Silva, Manori J.; Ye, Xiaoyun; Gaudreau, Éric; Patterson, Donald G.; Sjödin, Andreas

2016-01-01

Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers’ Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers’ Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants. PMID:25651899

Organic rice production: minimizing exposure to grain arsenic

USDA-ARS?s Scientific Manuscript database

The market demand for organically produced rice continues to increase in the USA. In 2011, some 23,000 acres of organic rice were produced with a $35 million value. Research is needed to optimize organic production practices to strengthen this developing market. In addition, there has been concern ...

THE SWELLING PROPERTIES OF SOIL ORGANIC MATTER AND THEIR RELATION TO SORPTION OF NON-IONIC ORGANIC COMPOUNDS

EPA Science Inventory

A method has been developed to measure the swelling properties of Concentrated natural organic materials in various organic liquids, and has been applied to various eat, pollen, chitin and cellulose samples. The swelling of these macromolecular aterials is rhe volumetric manifest...

SWELLING PROPERTIES OF SOIL ORGANIC MATTER AND THEIR RELATION TO SORPTION OF NON-IONIC ORGANIC COMPOUNDS

EPA Science Inventory

A method has been developed to measure the swelling properties of Concentrated natural organic materials in various organic liquids, and has been applied to various eat, pollen, chitin and cellulose samples. he swelling of these macromolecular aterials is rhe volumetric manifesta...

45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

Code of Federal Regulations, 2011 CFR

2011-10-01

... volunteers; (ii) Helping an organization develop an effective volunteer management system; (iii) Organizing..., infrastructure, and human resources of an organization that is meeting unmet community needs. Capacity-building activities help an organization gain greater independence and sustainability. (a) The AmeriCorps members you...

45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

Code of Federal Regulations, 2010 CFR

2010-10-01

... volunteers; (ii) Helping an organization develop an effective volunteer management system; (iii) Organizing..., infrastructure, and human resources of an organization that is meeting unmet community needs. Capacity-building activities help an organization gain greater independence and sustainability. (a) The AmeriCorps members you...

Exploring Biological Classification: The Unique Organism Project

ERIC Educational Resources Information Center

Haines, Sarah; Richman, Laila; Hartley, Renee; Schmid, Rachel

2017-01-01

The unique organism project was designed as a culminating assessment for a biological classification unit in a middle school setting. Students developed a model to represent their unique organism. Using the model, students were required to demonstrate how their unique organism interacts with its environment, and how its internal and external…

Organic Chemistry Self Instructional Package 10: Alkenes-Reactions 2.

ERIC Educational Resources Information Center

Zdravkovich, V.

This booklet, one of a series of 17 developed at Prince George's Community College, Largo, Maryland, provides an individualized, self-paced undergraduate organic chemistry instruction module designed to augment any course in organic chemistry but particularly those taught using the text "Organic Chemistry" by Morrison and Boyd. The…

Organic Chemistry Self Instructional Package 15: Benzene, Aromaticity.

ERIC Educational Resources Information Center

Zdravkovich, V.

This booklet, one of a series of 17 developed at Prince George's Community College, Largo, Maryland, provides an individualized, self-paced undergraduate organic chemistry instruction module designed to augment any course in organic chemistry but particularly those taught using the text "Organic Chemistry" by Morrison and Boyd. The…

Answering Big Questions through Self-Organized Learning

ERIC Educational Resources Information Center

Rix, Sally

2017-01-01

Self-organized learning was developed by Professor Sugata Mitra of Newcastle University on the foundation of his firm belief that learning will emerge spontaneously when children are encouraged to be curious and are allowed to self-organize. There are seven dedicated Self-Organized Learning Environments (SOLEs) that Mitra established in…

78 FR 40033 - Organ Procurement and Transplantation Network

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... regarding OPTN policy development for VCAs. They noted that VCA transplantation remains an experimental... best use of organs; shall be specific for each organ type; shall be designed to avoid wasting organs... suggested that, as an experimental field and given the small number of VCA transplants at this time, VCA...

Promotion of Evidence-Based Nursing by Polish and foreign nursing organizations.

PubMed

Wasowska, Iga; Repka, Iwona

2014-01-01

The aim of the review was to obtain information on specific activities undertaken by professional nursing organizations, in order to promote and develop Evidence-Based Nursing (EBN). The foreign organizations featured in the study actively promote EBN within their countries of origin. This activity is currently focused on the structural and financial measures (focused on extrinsic factors). Some organizations are lobbying governments for grants and general support, in order to further their use and development of EBN. Educational activities are still ongoing, which include the creation of the creation of new guidelines and publishing research in journals, along with the organization of periodic conferences. Polish Nurses Association was the only one not involved in any structural and financial activities.

Evolutionary Ecology of Organs: A Missing Link in Cancer Development?

PubMed

Thomas, Frédéric; Nesse, Randolph M; Gatenby, Robert; Gidoin, Cindy; Renaud, François; Roche, Benjamin; Ujvari, Beata

2016-08-01

There is striking variation in the incidence of cancer in human organs. Malignant tumors are common in the colon and breast but rare in the heart and small bowel. The uterus frequently develops benign fibroid tumors but uterine cancers are relatively rare. The organ-specific difference in cancer prevalence has been explained primarily by the relative roles of intrinsic and extrinsic risk factors. In this opinion article, we propose also considering organs as distinct but connected ecosystems whose different vulnerabilities to malignant transformation may be partially explained by how essential each organ is for survival through the age of reproduction. We present and discuss some of the basic concepts and assumptions of this perspective on evolutionary medicine. Copyright © 2016 Elsevier Inc. All rights reserved.

Developing Leadership Capacity through Organizational Learning

ERIC Educational Resources Information Center

Buchanan, Julia

2008-01-01

The relationship of human development to leadership growth and organizational learning is becoming more significant as organizations recognize the value of skilled leadership. In order to foster collective intelligence and innovation in groups, leadership throughout an organization benefits from the understanding of processes involved in…

Some Unintended Consequences of "Top Down" Organization Development

ERIC Educational Resources Information Center

White, Bernard J.; Ramsey, V. Jean

1978-01-01

An organizational development consultant is expected to perform a thorough and unbiased diagnosis of the organization's functioning. This is an account of a case study of the effect of top management influence on the consultant's awareness and definition of problems. (Author/MLF)

Perceptions of Organizational Effectiveness over Organizational Life Cycles.

ERIC Educational Resources Information Center

Cameron, Kim S.; Whetten, David A.

1981-01-01

Student participants at two universities played multisession simulation games involving the development of 18 organizations. Post-session surveys of 583 participants indicated that organizational effectiveness became more important to participants as the organizations developed. This suggests that future organizational effectiveness studies should…

Managing Programmatic Risk for Complex Space System Developments

NASA Technical Reports Server (NTRS)

Panetta, Peter V.; Hastings, Daniel; Brumfield, Mark (Technical Monitor)

2001-01-01

Risk management strategies have become a recent important research topic to many aerospace organizations as they prepare to develop the revolutionary complex space systems of the future. Future multi-disciplinary complex space systems will make it absolutely essential for organizations to practice a rigorous, comprehensive risk management process, emphasizing thorough systems engineering principles to succeed. Project managers must possess strong leadership skills to direct high quality, cross-disciplinary teams for successfully developing revolutionary space systems that are ever increasing in complexity. Proactive efforts to reduce or eliminate risk throughout a project's lifecycle ideally must be practiced by all technical members in the organization. This paper discusses some of the risk management perspectives that were collected from senior managers and project managers of aerospace and aeronautical organizations by the use of interviews and surveys. Some of the programmatic risks which drive the success or failure of projects are revealed. Key findings lead to a number of insights for organizations to consider for proactively approaching the risks which face current and future complex space systems projects.

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

PubMed Central

Recasens-Alvarez, Carles; Ferreira, Ana; Milán, Marco

2017-01-01

A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ. PMID:28045022

Aligning career development with organizational goals: working towards the development of a strong and sustainable workforce.

PubMed

Saxe-Braithwaite, Marcy; Carlton, Sandra; Bass, Brenda

2009-01-01

The rapidly changing world of healthcare is faced with many challenges, not the least of which is a diminishing workforce. Healthcare organizations must develop multiple strategies, not only to attract and retain employees, but also to ensure that workers are prepared for continuous change in the workplace, are working at their full scope of practice and are committed to, and accountable for, the provision of high-quality care. There is evidence that by creating a healthier workplace, improved patient care will follow. Aligning Healthy Workplace Initiatives with an organization's strategic goals, corporate culture and vision reinforces their importance within the organization. In this paper, we describe an innovative pilot to assess a career development program, one of multiple Healthy Workplace Initiatives taking place at Providence Care in Kingston, Ontario in support of our three strategic goals. The results of the pilot were very encouraging; subsequent success in obtaining funding from HealthForceOntario has allowed the implementation of a sustainable program of career development within the organization. More work is required to evaluate its long-term effectiveness.

HANABA TARANU regulates the shoot apical meristem and leaf development in cucumber (Cucumis sativus L.)

PubMed Central

Ding, Lian; Yan, Shuangshuang; Jiang, Li; Liu, Meiling; Zhang, Juan; Zhao, Jianyu; Zhao, Wensheng; Han, Ying-yan; Wang, Qian; Zhang, Xiaolan

2015-01-01

The shoot apical meristem (SAM) is essential for continuous organogenesis in higher plants, while the leaf is the primary source organ and the leaf shape directly affects the efficiency of photosynthesis. HANABA TARANU (HAN) encodes a GATA3-type transcription factor that functions in floral organ development, SAM organization, and embryo development in Arabidopsis, but is involved in suppressing bract outgrowth and promoting branching in grass species. Here the function of the HAN homologue CsHAN1 was characterized in cucumber, an important vegetable with great agricultural and economic value. CsHAN1 is predominantly expressed at the junction of the SAM and the stem, and can partially rescue the han-2 floral organ phenotype in Arabidopsis. Overexpression and RNAi of CsHAN1 transgenic cucumber resulted in retarded growth early after embryogenesis and produced highly lobed leaves. Further, it was found that CsHAN1 may regulate SAM development through regulating the WUSCHEL (WUS) and SHOOT MERISTEMLESS (STM) pathways, and mediate leaf development through a complicated gene regulatory network in cucumber. PMID:26320238

Regulation of cell-fate determination in Dictyostelium.

PubMed

Brown, J M; Firtel, R A

1999-12-15

A key step in the development of all multicellular organisms is the differentiation of specialized cell types. The eukaryotic microorganism Dictyostelium discoideum provides a unique experimental system for studying cell-type determination and spatial patterning in a developing multicellular organism. Unlike metazoans, which become multicellular by undergoing many rounds of cell division after fertilization of an egg, the social amoeba Dictyostelium achieves multicellularity by the aggregation of approximately 10(5) cells in response to nutrient depletion. Following aggregation, cell-type differentiation and morphogenesis result in a multicellular organism with only a few cell types that exhibit a defined patterning along the anterior-posterior axis of the organism. Analysis of the mechanisms that control these processes is facilitated by the relative simplicity of Dictyostelium development and the availability of molecular, genetic, and cell biological tools. Interestingly, analysis has shown that many molecules that play integral roles in the development of higher eukaryotes, such as PKA, STATs, and GSK-3, are also essential for cell-type differentiation and patterning in Dictyostelium. The role of these and other signaling pathways in the induction, maintenance, and patterning of cell types during Dictyostelium development is discussed.

Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys

PubMed Central

Lawrence, Melanie L.; Chang, C-Hong; Davies, Jamie A.

2015-01-01

Recent advances in renal tissue engineering have shown that dissociated, early renogenic tissue from the developing embryo can self-assemble into morphologically accurate kidney-like organs arranged around a central collecting duct tree. In order for such self-assembled kidneys to be useful therapeutically or as models for drug screening, it is necessary to demonstrate that they are functional. One of the main functional characteristics of mature kidneys is transport of organic anions and cations into and out of the proximal tubule. Here, we show that the transport function of embryonic kidneys allowed to develop in culture follows a developmental time-course that is comparable to embryonic kidney development in vivo. We also demonstrate that serially-reaggregated engineered kidneys can transport organic anions and cations through specific uptake and efflux channels. These results support the physiological relevance of kidneys grown in culture, a commonly used model for kidney development and research, and suggest that serially-reaggregated kidneys self-assembled from separated cells have some functional characteristics of intact kidneys. PMID:25766625

Brain anatomical networks in early human brain development.

PubMed

Fan, Yong; Shi, Feng; Smith, Jeffrey Keith; Lin, Weili; Gilmore, John H; Shen, Dinggang

2011-02-01

Recent neuroimaging studies have demonstrated that human brain networks have economic small-world topology and modular organization, enabling efficient information transfer among brain regions. However, it remains largely unknown how the small-world topology and modular organization of human brain networks emerge and develop. Using longitudinal MRI data of 28 healthy pediatric subjects, collected at their ages of 1 month, 1 year, and 2 years, we analyzed development patterns of brain anatomical networks derived from morphological correlations of brain regional volumes. The results show that the brain network of 1-month-olds has the characteristically economic small-world topology and nonrandom modular organization. The network's cost efficiency increases with the brain development to 1 year and 2 years, so does the modularity, providing supportive evidence for the hypothesis that the small-world topology and the modular organization of brain networks are established during early brain development to support rapid synchronization and information transfer with minimal rewiring cost, as well as to balance between local processing and global integration of information. Copyright © 2010. Published by Elsevier Inc.

Proximal—distal pattern formation in Drosophila: cell autonomous requirement for Distal-less gene activity in limb development

PubMed Central

Cohen, Stephen M.; Jürgens, Gerd

1989-01-01

Limb development in the Drosophila embryo requires a pattern-forming system to organize positional information along the proximal–distal axis of the limb. This system must function in the context of the well characterized anterior–posterior and dorsal–ventral pattern-forming systems that are required to organize the body plan of the embryo. By genetic criteria the Distal-less gene appears to play a central role in limb development. Lack-of-function Distal-less mutations cause the deletion of a specific subset of embryonic peripheral sense organs that represent the evolutionary remnants of larval limbs. Distal-less activity is also required in the imaginal discs for the development of adult limbs. This requirement is cell autonomous and region specific within the developing limb primordium. Production of genetically mosaic imaginal discs, in which clones of cells lack Distal-less activity, indicates the existence of an organized proximal–distal positional information in very young imaginal disc primordia. We suggest that this graded positional information may depend on the activity of the Distal-less gene. Images PMID:16453891

Agile methods in biomedical software development: a multi-site experience report.

PubMed

Kane, David W; Hohman, Moses M; Cerami, Ethan G; McCormick, Michael W; Kuhlmman, Karl F; Byrd, Jeff A

2006-05-30

Agile is an iterative approach to software development that relies on strong collaboration and automation to keep pace with dynamic environments. We have successfully used agile development approaches to create and maintain biomedical software, including software for bioinformatics. This paper reports on a qualitative study of our experiences using these methods. We have found that agile methods are well suited to the exploratory and iterative nature of scientific inquiry. They provide a robust framework for reproducing scientific results and for developing clinical support systems. The agile development approach also provides a model for collaboration between software engineers and researchers. We present our experience using agile methodologies in projects at six different biomedical software development organizations. The organizations include academic, commercial and government development teams, and included both bioinformatics and clinical support applications. We found that agile practices were a match for the needs of our biomedical projects and contributed to the success of our organizations. We found that the agile development approach was a good fit for our organizations, and that these practices should be applicable and valuable to other biomedical software development efforts. Although we found differences in how agile methods were used, we were also able to identify a set of core practices that were common to all of the groups, and that could be a focus for others seeking to adopt these methods.

Agile methods in biomedical software development: a multi-site experience report

PubMed Central

Kane, David W; Hohman, Moses M; Cerami, Ethan G; McCormick, Michael W; Kuhlmman, Karl F; Byrd, Jeff A

2006-01-01

Background Agile is an iterative approach to software development that relies on strong collaboration and automation to keep pace with dynamic environments. We have successfully used agile development approaches to create and maintain biomedical software, including software for bioinformatics. This paper reports on a qualitative study of our experiences using these methods. Results We have found that agile methods are well suited to the exploratory and iterative nature of scientific inquiry. They provide a robust framework for reproducing scientific results and for developing clinical support systems. The agile development approach also provides a model for collaboration between software engineers and researchers. We present our experience using agile methodologies in projects at six different biomedical software development organizations. The organizations include academic, commercial and government development teams, and included both bioinformatics and clinical support applications. We found that agile practices were a match for the needs of our biomedical projects and contributed to the success of our organizations. Conclusion We found that the agile development approach was a good fit for our organizations, and that these practices should be applicable and valuable to other biomedical software development efforts. Although we found differences in how agile methods were used, we were also able to identify a set of core practices that were common to all of the groups, and that could be a focus for others seeking to adopt these methods. PMID:16734914

Historical development and current status of organ procurement from death-row prisoners in China.

PubMed

Allison, Kirk C; Caplan, Arthur; Shapiro, Michael E; Els, Charl; Paul, Norbert W; Li, Huige

2015-12-03

In December 2014, China announced that only voluntarily donated organs from citizens would be used for transplantation after January 1, 2015. Many medical professionals worldwide believe that China has stopped using organs from death-row prisoners. In the present article, we briefly review the historical development of organ procurement from death-row prisoners in China and comprehensively analyze the social-political background and the legal basis of the announcement. The announcement was not accompanied by any change in organ sourcing legislations or regulations. As a fact, the use of prisoner organs remains legal in China. Even after January 2015, key Chinese transplant officials have repeatedly stated that death-row prisoners have the same right as regular citizens to "voluntarily donate" organs. This perpetuates an unethical organ procurement system in ongoing violation of international standards. Organ sourcing from death-row prisoners has not stopped in China. The 2014 announcement refers to the intention to stop the use of organs illegally harvested without the consent of the prisoners. Prisoner organs procured with "consent" are now simply labelled as "voluntarily donations from citizens". The semantic switch may whitewash sourcing from both death-row prisoners and prisoners of conscience. China can gain credibility only by enacting new legislation prohibiting use of prisoner organs and by making its organ sourcing system open to international inspections. Until international ethical standards are transparently met, sanctions should remain.

Post-transplantation Development of Food Allergies.

PubMed

Newman, Erik N; Firszt, Rafael

2018-01-29

The development of food allergies is increasingly being recognized as a post-solid organ transplant complication. In this article, we review the spectrum of post-transplant food allergy development and the proposed mechanisms for de novo food allergies and the clinical significance they pose. The development of new food allergies is disproportionately associated with pediatric liver transplants, where it occurs in up to 38% of select populations. The mechanism of food allergy development is not completely understood; however, it is likely promoted by unbalanced immune suppression. De novo food allergy development is a common complication of solid organ transplants with the highest risk occurring in pediatric liver transplant recipients. There are likely multiple mechanisms for food allergy development including passive transfer of membrane-bound IgE and lymphocytes from donor to recipient, as well as loss of food tolerance and active development of new food allergies. The optimal management of food allergies following organ transplants has not been well researched but may include changing the immune suppression regimen if the food allergy does not resolve without intervention.

Developments in Analytical Chemistry: Acoustically Levitated Drop Reactors for Enzyme Reaction Kinetics and Single-Walled Carbon Nanotube-Based Sensors for Detection of Toxic Organic Phosphonates

ERIC Educational Resources Information Center

Field, Christopher Ryan

2009-01-01

Developments in analytical chemistry were made using acoustically levitated small volumes of liquid to study enzyme reaction kinetics and by detecting volatile organic compounds in the gas phase using single-walled carbon nanotubes. Experience gained in engineering, electronics, automation, and software development from the design and…

New Developments in Wood-Destroying Organisms from the International Research Group on Wood Preservation \\t

Treesearch

Elmer L. Schmidt

1991-01-01

New developments in wood-destroying organisms and in wood protection from the 20th annual meeting (May 1989 at Lappeenranta, Finland) of the International Research Group on Wood Preservation (IRG) are highlighted in the areas of biological control of fungi, dry rot, decay mechanisms and product problems, new techniques, insect problems and control, and developments in...

The Development of Multiple Intelligence Capabilities for Early Childhood Development Center, Local Administration Organization in Chaiyaphum Province

ERIC Educational Resources Information Center

Siphai, Sunan; Supandee, Terdsak; Raksapuk, Chunpit; Poopayang, Piangkhae; Kratoorerk, Sangsan

2017-01-01

The aim of this research is to promote multiple intelligence capabilities for Early Childhood Care Center of a Sub-district Administration Organization in Chaiyaphum Province. The sample applied were 61 children aging between 3 and 5 years old at Child Development Center, Tambon Ban Kok, Amphoe Chaturus, Chaiyaphum Province, who were selected…

The Effective Use of Scientific and Technical Information in Industrial and Non-Profit Settings: A Study of Managerial Interventions.

ERIC Educational Resources Information Center

Shapero, Albert; And Others

A study conducted in a non profit research and development organization and the technical development department of a profit corporation was designed to develop and implement interventions that would modify the information-communication behaviors of the technical professionals in these organizations, and to measure and analyze the effects of the…

Self-organizing sensing and actuation for automatic control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, George Shu-Xing

A Self-Organizing Process Control Architecture is introduced with a Sensing Layer, Control Layer, Actuation Layer, Process Layer, as well as Self-Organizing Sensors (SOS) and Self-Organizing Actuators (SOA). A Self-Organizing Sensor for a process variable with one or multiple input variables is disclosed. An artificial neural network (ANN) based dynamic modeling mechanism as part of the Self-Organizing Sensor is described. As a case example, a Self-Organizing Soft-Sensor for CFB Boiler Bed Height is presented. Also provided is a method to develop a Self-Organizing Sensor.

Developing Statistical Models to Assess Transplant Outcomes Using National Registries: The Process in the United States.

PubMed

Snyder, Jon J; Salkowski, Nicholas; Kim, S Joseph; Zaun, David; Xiong, Hui; Israni, Ajay K; Kasiske, Bertram L

2016-02-01

Created by the US National Organ Transplant Act in 1984, the Scientific Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program and organ procurement organization performance in the United States. These reports include risk-adjusted assessments of graft and patient survival, and programs performing worse or better than expected are identified. The SRTR currently maintains 43 risk adjustment models for assessing posttransplant patient and graft survival and, in collaboration with the SRTR Technical Advisory Committee, has developed and implemented a new systematic process for model evaluation and revision. Patient cohorts for the risk adjustment models are identified, and single-organ and multiorgan transplants are defined, then each risk adjustment model is developed following a prespecified set of steps. Model performance is assessed, the model is refit to a more recent cohort before each evaluation cycle, and then it is applied to the evaluation cohort. The field of solid organ transplantation is unique in the breadth of the standardized data that are collected. These data allow for quality assessment across all transplant providers in the United States. A standardized process of risk model development using data from national registries may enhance the field.

Learning To Bridge the Digital Divide: Schooling for Tomorrow. Education and Skills. [National Center on Adult Literacy (NCAL)/Organization for Economic Cooperation and Development (OECD) Roundtable (5th, Philadelphia, Pennsylvania, December 8-10, 1999)].

ERIC Educational Resources Information Center

Jame, Edwyn; Istance, David

This publication builds on the papers and discussions of the Fifth National Center on Adult Literacy (NCAL)/Organization for Economic Cooperation and Development (OECD) Roundtable. The volume presents an analysis of the "learning digital divide" in different countries--developed and developing--and the policies and innovations designed…

Acquisition of a High Performance Computer Cluster for Materials Research and Education

DTIC Science & Technology

2015-04-17

separation in all-organic and hybrid organic- inorganic solar cells. The outcome of the project 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND SUBTITLE 13...diffusion and interfacial charge separation in all-organic and hybrid organic- inorganic solar cells. The outcome of the project is the development...simulations to predict charge carrier mobilities, exciton diffusion and interfacial charge separation in all- organic and hybrid organic- inorganic solar

Career planning and development for nurses: the time has come.

PubMed

Donner, G J; Wheeler, M M

2001-06-01

Developments in how the nursing profession is perceived by nurses and by society, along with unparalleled changes in health care systems, have created an environment in which individual nurses must take control of their careers and futures. Educators, employers and professional organizations also have a key role to play in fostering the career planning and development of nurses, usually the largest employee group in most health care organizations. This article provides an overview of what career planning and development is and why it is important for nurses. A career planning and development model is described that provides nurses with a focused strategy to take greater responsibility for engaging in the ongoing planning process that is crucial throughout the major stages of their career. Finally, educators, employers and professional organizations are challenged to collaborate with individual nurses on career-development activities that will enable nurses to continue to provide high-quality care in ever-changing health care systems.

IS0 9000 Implementation and Assessment: A Guide to Developing and Evaluating Quality Management Systems

NASA Technical Reports Server (NTRS)

Navarro, Robert J.; Grimm, Barry

1996-01-01

The agency has developed this reference publication to aid NASA organizations and their suppliers in the transition to IS0 9000. This guide focuses on the standard s intent, clarifies its requirements, offers implementation examples and highlights interrelated areas. It can assist anyone developing or evaluating NASA or supplier quality management systems. The IS0 9000 standards contain the basic elements for managing those processes that affect an organization's ability to consistently meet customer requirements. IS0 9000 was developed through the International Organization for Standardization and has been adopted as the US. national standard. These standards define a flexible foundation for customer focused process measurement, management and improvement that is the hallmark of world class enterprises.

Comperative investigations of non chemical weed management methods in Hungary.

PubMed

Pali, Orsolya; Reisinger, Peter; Pomsar, Peter

2007-01-01

Organic farming has an increasing tendency in Hungary because of growing consumers' demands according to organic products not only in inland but also in the countries of the European Union. Developments of weed control methods in organically cropped field plants have become conspicuous next to developing chemical weed management methods of convencionally cropped cultural plants. The aim of our investigations was to make comperative investigations of non chemical weed control methods in wide rowed plants.

Fate and Enumeration Problems of Fecal Coliform Bacteria in Runoff Waters from Terrestrial Ecosystems.

DTIC Science & Technology

1980-09-01

bacteria and also for the development of a surface organic layer on the plots that aided in the removal of wastewater bacteria through filtration and...better conditions not only for protozoan predation of fecal bacteria but also for the development of a surface organic layer on the plots. This organic... layer acted to increase the detention of the wastewater bacteria through filtration and entrapment. The intermittently treated plots promoted the

Trends in unrelated-donor kidney transplantation in the developing world.

PubMed

Barsoum, Rashad S

2008-11-01

Living unrelated donors (LUDs) constitute an incremental source of kidneys for transplantation at a global level. Excellent outcomes are reported, superior to those of deceased-donor transplantation and comparable to related donor transplantation. LUD include six categories: spouses, distant relatives, paired-exchange, living-deceased exchange, and non-directed and directed donors. Although a financial reward may be involved in any of these categories, it is in the declared selling of organs that ethical concerns have intensified. There are three patterns of paid LUDs in the developing world: organized, erratic and commercial. The only model of organized LUDs is in Iran, where a central agency assigns and compensates the donors. Erratic LUD transplantation has been experienced, and subsequently banned, in the development of transplant programmes in most developing countries. However, the tightness and enforcement of the official ban are geographically different, providing variable room for uncontrolled trafficking. Commercial transplantation has, thus, become phenomenal in a few countries, gradually evolving into an organized business that follows market dynamics, including advertisement, brokerage, commissions, auctions and tourism. While most international organizations and activist groups condemn commercial transplantation, it is often perceived, in certain cultures and under particular socioeconomic standards, as a human right that meets the demands of all stakeholders, and should be organized rather than declined just for the purpose of meeting the values of a third party.

Self-organization of developing embryo using scale-invariant approach

PubMed Central

2011-01-01

Background Self-organization is a fundamental feature of living organisms at all hierarchical levels from molecule to organ. It has also been documented in developing embryos. Methods In this study, a scale-invariant power law (SIPL) method has been used to study self-organization in developing embryos. The SIPL coefficient was calculated using a centro-axial skew symmetrical matrix (CSSM) generated by entering the components of the Cartesian coordinates; for each component, one CSSM was generated. A basic square matrix (BSM) was constructed and the determinant was calculated in order to estimate the SIPL coefficient. This was applied to developing C. elegans during early stages of embryogenesis. The power law property of the method was evaluated using the straight line and Koch curve and the results were consistent with fractal dimensions (fd). Diffusion-limited aggregation (DLA) was used to validate the SIPL method. Results and conclusion The fractal dimensions of both the straight line and Koch curve showed consistency with the SIPL coefficients, which indicated the power law behavior of the SIPL method. The results showed that the ABp sublineage had a higher SIPL coefficient than EMS, indicating that ABp is more organized than EMS. The fd determined using DLA was higher in ABp than in EMS and its value was consistent with type 1 cluster formation, while that in EMS was consistent with type 2. PMID:21635789

Self-organization of developing embryo using scale-invariant approach.

PubMed

Tiraihi, Ali; Tiraihi, Mujtaba; Tiraihi, Taki

2011-06-03

Self-organization is a fundamental feature of living organisms at all hierarchical levels from molecule to organ. It has also been documented in developing embryos. In this study, a scale-invariant power law (SIPL) method has been used to study self-organization in developing embryos. The SIPL coefficient was calculated using a centro-axial skew symmetrical matrix (CSSM) generated by entering the components of the Cartesian coordinates; for each component, one CSSM was generated. A basic square matrix (BSM) was constructed and the determinant was calculated in order to estimate the SIPL coefficient. This was applied to developing C. elegans during early stages of embryogenesis. The power law property of the method was evaluated using the straight line and Koch curve and the results were consistent with fractal dimensions (fd). Diffusion-limited aggregation (DLA) was used to validate the SIPL method. The fractal dimensions of both the straight line and Koch curve showed consistency with the SIPL coefficients, which indicated the power law behavior of the SIPL method. The results showed that the ABp sublineage had a higher SIPL coefficient than EMS, indicating that ABp is more organized than EMS. The fd determined using DLA was higher in ABp than in EMS and its value was consistent with type 1 cluster formation, while that in EMS was consistent with type 2. © 2011 Tiraihi et al; licensee BioMed Central Ltd.

Development of a culture of sustainability in health care organizations.

PubMed

Ramirez, Bernardo; West, Daniel J; Costell, Michael M

2013-01-01

This paper aims to examine the concept of sustainability in health care organizations and the key managerial competencies and change management strategies needed to implant a culture of sustainability. Competencies and management development strategies needed to engrain this corporate culture of sustainability are analyzed in this document. This paper draws on the experience of the authors as health care executives and educators developing managerial competencies with interdisciplinary and international groups of executives in the last 25 years, using direct observation, interviews, discussions and bibliographic evidence. With a holistic framework for sustainability, health care managers can implement strategies for multidisciplinary teams to respond to the constant change, fine-tune operations and successfully manage quality of care. Managers can mentor students and provide in-service learning experiences that integrate knowledge, skills, and abilities. Further empirical research needs to be conducted on these interrelated innovative topics. Health care organizations around the world are under stakeholders' pressure to provide high quality, cost-effective, accessible and sustainable services. Professional organizations and health care providers can collaborate with university graduate health management education programs to prepare competent managers in all the dimensions of sustainability. The newly designated accountable care organizations represent an opportunity for managers to address the need for sustainability. Sustainability of health care organizations with the holistic approach discussed in this paper is an innovative and practical approach to quality improvement that merits further development.

Single-Cell RNA Sequencing of the Bronchial Epithelium in Smokers with Lung Cancer

DTIC Science & Technology

2017-07-01

and to discuss library preparations protocols and data analysis techniques. The goal is to develop a single cell sequencing analysis toolkit . In...Research Support LUNGevity Career Development Award What other organizations were involved as partners? Organization Name: Broad Institute 19

A GLOBAL INVENTORY OF VOLATILE ORGANIC COMPOUND EMISSIONS FROM ANTHROPOGENIC SOURCES

EPA Science Inventory

As part of an effort to assess the potential impacts associated with global climate change, the U.S. Environmental Protection Agency's Office of Research and Development is supporting global atmospheric chemistry research by developing global scale estimates of volatile organic c...

Vocational Training and Rural Development in Algeria

ERIC Educational Resources Information Center

Boumaza, S.; Gara, A.

1973-01-01

Better organization of the agricultural sector, expansion of production capabilities, increased employment, satisfaction of the country's needs, and improved productivity are the guidelines considered in the planning and development of the agricultural vocational training system in Algeria. Charts illustrate and clarify the organization of this…

Creating Competence: Perspectives and Practices in Organizations.

ERIC Educational Resources Information Center

Mulder, Martin

Creating competence has become a major issue in organizations. Various authors contend that competency management has the potential of integrating organizational strategy, human-resource instruments, and human-resource development; that competency development can lead to performance improvement; and that it can help Human Resource Development…

RESEARCH AND PRODUCT DEVELOPMENT OF LOW-VOC WOOD COATINGS

EPA Science Inventory

The report discusses a project, cofunded by the South Coast Air Quality Management District (SCAQMD) and the U.S. EPA, to develop a new, low volatile organic compound (VOC) wood coating. Traditional wood furniture coating technologies contain organic solvents which become air pol...