41 CFR 101-26.508 - Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band).

Code of Federal Regulations, 2014 CFR

2014-07-01

... processing (EDP) tape and instrumentation tape (wide and intermediate band). 101-26.508 Section 101-26.508... Programs § 101-26.508 Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band). Procurement by Federal agencies of EDP tape and instrumentation tape (wide and intermediate band...

41 CFR 101-26.508 - Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band).

Code of Federal Regulations, 2010 CFR

2010-07-01

... processing (EDP) tape and instrumentation tape (wide and intermediate band). 101-26.508 Section 101-26.508... Programs § 101-26.508 Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band). Procurement by Federal agencies of EDP tape and instrumentation tape (wide and intermediate band...

41 CFR 101-26.508 - Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band).

Code of Federal Regulations, 2012 CFR

2012-07-01

... processing (EDP) tape and instrumentation tape (wide and intermediate band). 101-26.508 Section 101-26.508... Programs § 101-26.508 Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band). Procurement by Federal agencies of EDP tape and instrumentation tape (wide and intermediate band...

41 CFR 101-26.508 - Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band).

Code of Federal Regulations, 2011 CFR

2011-07-01

... processing (EDP) tape and instrumentation tape (wide and intermediate band). 101-26.508 Section 101-26.508... Programs § 101-26.508 Electronic data processing (EDP) tape and instrumentation tape (wide and intermediate band). Procurement by Federal agencies of EDP tape and instrumentation tape (wide and intermediate band...

Life-Cycle Cost/Benefit Assessment of Expedite Departure Path (EDP)

NASA Technical Reports Server (NTRS)

Wang, Jianzhong Jay; Chang, Paul; Datta, Koushik

2005-01-01

This report presents a life-cycle cost/benefit assessment (LCCBA) of Expedite Departure Path (EDP), an air traffic control Decision Support Tool (DST) currently under development at NASA. This assessment is an update of a previous study performed by bd Systems, Inc. (bd) during FY01, with the following revisions: The life-cycle cost assessment methodology developed by bd for the previous study was refined and calibrated using Free Flight Phase 1 (FFP1) cost information for Traffic Management Advisor (TMA, or TMA-SC in the FAA's terminology). Adjustments were also made to the site selection and deployment scheduling methodology to include airspace complexity as a factor. This technique was also applied to the benefit extrapolation methodology to better estimate potential benefits for other years, and at other sites. This study employed a new benefit estimating methodology because bd s previous single year potential benefit assessment of EDP used unrealistic assumptions that resulted in optimistic estimates. This methodology uses an air traffic simulation approach to reasonably predict the impacts from the implementation of EDP. The results of the costs and benefits analyses were then integrated into a life-cycle cost/benefit assessment.

Parallel synthesis of libraries of anodic and cathodic functionalized electrodeposition paints as immobilization matrix for amperometric biosensors.

PubMed

Ngounou, Bertrand; Aliyev, Elchin H; Guschin, Dmitrii A; Sultanov, Yusif M; Efendiev, Ayaz A; Schuhmann, Wolfgang

2007-09-01

The integration of flexible anchoring groups bearing imidazolyl or pyridyl substituents into the structure of electrodeposition paints (EDP) is the basis for the parallel synthesis of a library containing 107 members of different cathodic and anodic EDPs with a high variation in polymer properties. The obtained EDPs were used as immobilization matrix for biosensor fabrication using glucose oxidase as a model enzyme. Amperometric glucose sensors based on the different EDPs showed a wide variation in their sensor characteristics with respect to the apparent Michaelis-Menten constant (KM(app)) representing the linear measuring range and the maximum current (Imax(app)). Based on these results first assumptions concerning the impact of different side chains in the EDP on the expected biosensor properties could be obtained allowing for an improved rational optimization of EDPs used as immobilization matrix in amperometric biosensors.

A Method for Making Cross-Comparable Estimates of the Benefits of Decision Support Technologies for Air Traffic Management

NASA Technical Reports Server (NTRS)

Lee, David; Long, Dou; Etheridge, Mel; Plugge, Joana; Johnson, Jesse; Kostiuk, Peter

1998-01-01

We present a general method for making cross comparable estimates of the benefits of NASA-developed decision support technologies for air traffic management, and we apply a specific implementation of the method to estimate benefits of three decision support tools (DSTs) under development in NASA's advanced Air Transportation Technologies Program: Active Final Approach Spacing Tool (A-FAST), Expedite Departure Path (EDP), and Conflict Probe and Trial Planning Tool (CPTP). The report also reviews data about the present operation of the national airspace system (NAS) to identify opportunities for DST's to reduce delays and inefficiencies.

Evolution of embryonic developmental period in the marine bird families Alcidae and Spheniscidae: roles for nutrition and predation?

PubMed Central

2010-01-01

Background Nutrition and predation have been considered two primary agents of selection important in the evolution of avian life history traits. The relative importance of these natural selective forces in the evolution of avian embryonic developmental period (EDP) remain poorly resolved, perhaps in part because research has tended to focus on a single, high taxonomic-level group of birds: Order Passeriformes. The marine bird families Alcidae (auks) and Spheniscidae (penguins) exhibit marked variation in EDP, as well as behavioural and ecological traits ultimately linked to EDP. Therefore, auks and penguins provide a unique opportunity to assess the natural selective basis of variation in a key life-history trait at a low taxonomic-level. We used phylogenetic comparative methods to investigate the relative importance of behavioural and ecological factors related to nutrition and predation in the evolution of avian EDP. Results Three behavioural and ecological variables related to nutrition and predation risk (i.e., clutch size, activity pattern, and nesting habits) were significant predictors of residual variation in auk and penguin EDP based on models predicting EDP from egg mass. Species with larger clutch sizes, diurnal activity patterns, and open nests had significantly shorter EDPs. Further, EDP was found to be longer among birds which forage in distant offshore waters, relative to those that foraged in near shore waters, in line with our predictions, but not significantly so. Conclusion Current debate has emphasized predation as the primary agent of selection driving avian life history diversification. Our results suggest that both nutrition and predation have been important selective forces in the evolution of auk and penguin EDP, and highlight the importance of considering these questions at lower taxonomic scales. We suggest that further comparative studies on lower taxonomic-level groups will continue to constructively inform the debate on evolutionary determinants of avian EDP, as well as other life history parameters. PMID:20546608

Evolution of embryonic developmental period in the marine bird families Alcidae and Spheniscidae: roles for nutrition and predation?

PubMed

Hipfner, J Mark; Gorman, Kristen B; Vos, Rutger A; Joy, Jeffrey B

2010-06-14

Nutrition and predation have been considered two primary agents of selection important in the evolution of avian life history traits. The relative importance of these natural selective forces in the evolution of avian embryonic developmental period (EDP) remain poorly resolved, perhaps in part because research has tended to focus on a single, high taxonomic-level group of birds: Order Passeriformes. The marine bird families Alcidae (auks) and Spheniscidae (penguins) exhibit marked variation in EDP, as well as behavioural and ecological traits ultimately linked to EDP. Therefore, auks and penguins provide a unique opportunity to assess the natural selective basis of variation in a key life-history trait at a low taxonomic-level. We used phylogenetic comparative methods to investigate the relative importance of behavioural and ecological factors related to nutrition and predation in the evolution of avian EDP. Three behavioural and ecological variables related to nutrition and predation risk (i.e., clutch size, activity pattern, and nesting habits) were significant predictors of residual variation in auk and penguin EDP based on models predicting EDP from egg mass. Species with larger clutch sizes, diurnal activity patterns, and open nests had significantly shorter EDPs. Further, EDP was found to be longer among birds which forage in distant offshore waters, relative to those that foraged in near shore waters, in line with our predictions, but not significantly so. Current debate has emphasized predation as the primary agent of selection driving avian life history diversification. Our results suggest that both nutrition and predation have been important selective forces in the evolution of auk and penguin EDP, and highlight the importance of considering these questions at lower taxonomic scales. We suggest that further comparative studies on lower taxonomic-level groups will continue to constructively inform the debate on evolutionary determinants of avian EDP, as well as other life history parameters.

Conservation planning on eroded land based of local wisdom in Kintamani sub-district, province of Bali

NASA Astrophysics Data System (ADS)

Sri Sumarniasih, Made; Antara, Made

2017-01-01

Location determination is based on the compilation of soil type’s map, land use map and slope map. Uniformity of soil type, slope and land use is classified into one unit of land, so that there are 48 units of land to be use as sample points. The purpose of this research are to identify patterns of land use, determine the amount of erosion, the amount of erosion that is tolerable and erosion control through a conservation plan based on local wisdom. The erosion prediction used USLE method, erosion of tolerated (Edp) using the formula Hammer. Results of laboratory and field observations having analyzed using USLE showed some level of erosion on land use in the Kintamani classified from very mild to very severe: 4.79 to 370.60 t ha-1yr-1, while Edp ranges from 30.00 to 48.00 t ha-1 yr-1. erosion Severe to very severe found on the use of mixed garden/citrus garden, dry land and shrubs/ reeds. The planned of use of land is intercropping annuals with horticultural crops (cabbage), citrus trees intercropped with flower of gumitir and bush land planting with elephant grass on a slope of less than 25% and planted of trees on land with a slope above 25%.

Evolutionary psychology and evolutionary developmental psychology: understanding the evolution of human behavior and development.

PubMed

Hernández Blasi, Carlos; Causey, Kayla

2010-02-01

This is an introduction to this special issue on evolutionary psychology (EP) and evolutionary developmental psychology (EDP). We suggest here that, contrary to some common assumptions, mainstream psychology continues to be essentially non Darwinian and that EP and EDP are new approaches that can potentially help us to change this situation. We then present the organization of the special issue (composed of six papers). We conclude that evolution is certainly not the final consideration in psychology, but emphasize its importance as the basis upon which all modern behaviors and development are built.

The External Diploma Program (EDP) and the SCANS Report. The External Diploma Program (EDP) and CASAS.

ERIC Educational Resources Information Center

Harvey, Florence

These two presentations discuss the National External Diploma Program (EDP) sponsored by the American Council on Education and its relationship to the Department of Labor's Secretary's Commission on Achieving Necessary Skills (SCANS) report and to the Comprehensive Adult Student Assessment System (CASAS). The first presentation focuses on the…

Examining Escherichia coli glycolytic pathways, catabolite repression, and metabolite channeling using Δpfk mutants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hollinshead, Whitney D.; Rodriguez, Sarah; Martin, Hector Garcia

Background: Glycolysis breakdowns glucose into essential building blocks and ATP/NAD(P)H for the cell, occupying a central role in its growth and bio-production. Among glycolytic pathways, the Entner Doudoroff pathway (EDP) is a more thermodynamically favorable pathway with fewer enzymatic steps than either the Embden-Meyerhof-Parnas pathway (EMPP) or the oxidative pentose phosphate pathway (OPPP). However, Escherichia coli do not use their native EDP for glucose metabolism. Results: Overexpression of edd and eda in E. coli to enhance EDP activity resulted in only a small shift in the flux directed through the EDP (~20 % of glycolysis flux). Disrupting the EMPP bymore » phosphofructokinase I (pfkA) knockout increased flux through OPPP (~60 % of glycolysis flux) and the native EDP (~14 % of glycolysis flux), while overexpressing edd and eda in this ΔpfkA mutant directed ~70 % of glycolytic flux through the EDP. The downregulation of EMPP via the pfkA deletion significantly decreased the growth rate, while EDP overexpression in the ΔpfkA mutant failed to improve its growth rates due to metabolic burden. However, the reorganization of E. coli glycolytic strategies did reduce glucose catabolite repression. The ΔpfkA mutant in glucose medium was able to cometabolize acetate via the citric acid cycle and gluconeogenesis, while EDP overexpression in the ΔpfkA mutant repressed acetate flux toward gluconeogenesis. Moreover, 13C-pulse experiments in the ΔpfkA mutants showed unsequential labeling dynamics in glycolysis intermediates, possibly suggesting metabolite channeling (metabolites in glycolysis are pass from enzyme to enzyme without fully equilibrating within the cytosol medium). Conclusions: We engineered E. coli to redistribute its native glycolytic flux. The replacement of EMPP by EDP did not improve E. coli glucose utilization or biomass growth, but alleviated catabolite repression. More importantly, our results supported the hypothesis of channeling in the glycolytic pathways, a potentially overlooked mechanism for regulating glucose catabolism and coutilization of other substrates. The presence of channeling in native pathways, if proven true, would affect synthetic biology applications and metabolic modeling.« less

Examining Escherichia coli glycolytic pathways, catabolite repression, and metabolite channeling using Δpfk mutants

DOE PAGES

Hollinshead, Whitney D.; Rodriguez, Sarah; Martin, Hector Garcia; ...

2016-10-10

Background: Glycolysis breakdowns glucose into essential building blocks and ATP/NAD(P)H for the cell, occupying a central role in its growth and bio-production. Among glycolytic pathways, the Entner Doudoroff pathway (EDP) is a more thermodynamically favorable pathway with fewer enzymatic steps than either the Embden-Meyerhof-Parnas pathway (EMPP) or the oxidative pentose phosphate pathway (OPPP). However, Escherichia coli do not use their native EDP for glucose metabolism. Results: Overexpression of edd and eda in E. coli to enhance EDP activity resulted in only a small shift in the flux directed through the EDP (~20 % of glycolysis flux). Disrupting the EMPP bymore » phosphofructokinase I (pfkA) knockout increased flux through OPPP (~60 % of glycolysis flux) and the native EDP (~14 % of glycolysis flux), while overexpressing edd and eda in this ΔpfkA mutant directed ~70 % of glycolytic flux through the EDP. The downregulation of EMPP via the pfkA deletion significantly decreased the growth rate, while EDP overexpression in the ΔpfkA mutant failed to improve its growth rates due to metabolic burden. However, the reorganization of E. coli glycolytic strategies did reduce glucose catabolite repression. The ΔpfkA mutant in glucose medium was able to cometabolize acetate via the citric acid cycle and gluconeogenesis, while EDP overexpression in the ΔpfkA mutant repressed acetate flux toward gluconeogenesis. Moreover, 13C-pulse experiments in the ΔpfkA mutants showed unsequential labeling dynamics in glycolysis intermediates, possibly suggesting metabolite channeling (metabolites in glycolysis are pass from enzyme to enzyme without fully equilibrating within the cytosol medium). Conclusions: We engineered E. coli to redistribute its native glycolytic flux. The replacement of EMPP by EDP did not improve E. coli glucose utilization or biomass growth, but alleviated catabolite repression. More importantly, our results supported the hypothesis of channeling in the glycolytic pathways, a potentially overlooked mechanism for regulating glucose catabolism and coutilization of other substrates. The presence of channeling in native pathways, if proven true, would affect synthetic biology applications and metabolic modeling.« less

Dilational symmetry-breaking in thermodynamics

NASA Astrophysics Data System (ADS)

Lin, Chris L.; Ordóñez, Carlos R.

2017-04-01

Using thermodynamic relations and dimensional analysis we derive a general formula for the thermodynamical trace 2{ E}-DP for nonrelativistic systems and { E}-DP for relativistic systems, where D is the number of spatial dimensions, in terms of the microscopic scales of the system within the grand canonical ensemble. We demonstrate the formula for several cases, including anomalous systems which develop scales through dimensional transmutation. Using this relation, we make explicit the connection between dimensional analysis and the virial theorem. This paper is focused mainly on the non-relativistic aspects of this relation.

The value of novel invasive hemodynamic parameters added to the TIMI risk score for short-term prognosis assessment in patients with ST segment elevation myocardial infarction.

PubMed

Tesak, Martin; Kala, Petr; Jarkovsky, Jiri; Poloczek, Martin; Bocek, Otakar; Jerabek, Petr; Kubková, Lenka; Manousek, Jan; Spinar, Jindrich; Mebazaa, Alexandre; Parenica, Jiri; Cohen-Solal, Alain

2016-07-01

We compared the prognostic capacity of conventional and novel invasive parameters derived from the slope of the preload recruitable stroke work relationship (PRSW) in STEMI patients and assessed their contribution to the TIMI risk score. Left ventricular end-diastolic pressure (EDP), ejection fraction (EF), pressure adjusted maximum rate of pressure change in the left ventricle (dP/dt/P), aortic systolic pressure to EDP ratio (SBP/EDP) and end-diastolic volume adjusted stroke work (EW), derived from the slope of the PRSW relationship, were obtained during the emergency cardiac catheterization in 523 STEMI patients. The predictive power of the analyzed parameters for 30-day and 1-year mortality was evaluated using C-statistics and reclassification analysis was adopted to assess the improvement in TIMI score. The highest area under the curve (AUC) values for 30-day mortality were observed for EW (0.872(95% confidence interval 0.801-0.943)), SBP/EDP (0.843(0.758-0.928)) and EF (0.833(0.735-0.931)); p<0.001 for all values. For 1-year mortality the best predictive value was found for EW (0.806(0.724-0.887) and EF (0.793(0.703-0.883)); p<0.001 for both. The addition of EDP, SBP/EDP ratio and EW to TIMI score significantly increased the AUC according to De Long's test. For 30-day mortality, increased discriminative power following addition to the TIMI score was observed for EW and SBP/EDP (Integrated Discrimination Improvement was 0.086(0.033-0.140), p=0.002 and 0.078(0.028-0.128), p=0.002, respectively). EW and SBP/EDP are prognostic markers with high predictive value for 30-day and 1-year mortality. Both parameters, easily obtained during emergency catheterization, improve the discriminatory capacity of the TIMI score for 30-day mortality. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Preclinical and Clinical Resistance Profile of EDP-239, a Novel Hepatitis C Virus NS5A Inhibitor.

PubMed

Owens, Christopher M; Brasher, Bradley B; Polemeropoulos, Alex; Rhodin, Michael H J; McAllister, Nicole; Wong, Kelly A; Jones, Christopher T; Jiang, Lijuan; Lin, Kai; Or, Yat Sun

2016-10-01

EDP-239, a potent and selective hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor developed for the treatment of HCV infection, has been investigated in vitro and in vivo This study sought to characterize genotypic changes in the HCV NS5A sequence of genotype 1 (GT1) replicons and to compare those changes to GT1 viral RNA mutations isolated from clinical trial patients. Resistance selection experiments in vitro using a subgenomic replicon identified resistance-associated mutations (RAMs) at GT1a NS5A amino acid positions 24, 28, 30, 31, and 93 that confer various degrees of resistance to EDP-239. Key RAMs were similarly identified in GT1b NS5A at amino acid positions 31 and 93. Mutations F36L in GT1a and A92V in GT1b do not confer resistance to EDP-239 individually but were found to enhance the resistance of GT1a K24R and GT1b Y93H. RAMs were identified in GT1 patients at baseline or after dosing with EDP-239 that were similar to those detected in vitro Baseline RAMs identified at NS5A position 93 in GT1, or positions 28 or 30 in GT1a only, correlated with a reduced treatment response. RAMs at additional positions were also detected and may have contributed to reduced EDP-239 efficacy. The most common GT1a and GT1b RAMs found to persist up to weeks 12, 24, or 48 were those at NS5A positions 28, 30, 31, 58 (GT1a only), and 93. Those RAMs persisting at the highest frequencies up to weeks 24 or 48 were L31M and Q30H/R for GT1a and L31M and Y93H for GT1b. (This study has been registered at ClinicalTrials.gov under identifier NCT01856426.). Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Risk and protective factors for heat-related events among older adults of Southern Quebec (Canada): The NuAge study.

PubMed

Laverdière, Émélie; Payette, Hélène; Gaudreau, Pierrette; Morais, José A; Shatenstein, Bryna; Généreux, Mélissa

2016-10-20

Extreme heat is known to increase heat-related health outcomes (HRHO). Incidence and predictors of HRHO were examined among older adults living in Quebec (Canada). This prospective five-year study used data from the first follow-up of community-dwelling older adults from the NuAge cohort (2005-2006), located in three health regions of Southern Quebec. Medical, social and environmental factors, identified in Health Canada guidelines (2011), were used to develop the Older Adult Health Vulnerability Index (OAHVI). HRHO, obtained from a medico-administrative database, were defined as events occurring on a hot day (maximal temperature ≥30°C) between 2006 and 2010. Two outcomes were examined: heat-related 1) emergency department presentations (EDPs) and 2) health events (i.e., EDP, hospitalizations or deaths). Multivariate logistic regressions were performed to assess the associations between risk and protective factors, including OAHVI, and both outcomes. EDP and hospitalizations were, respectively, 2.6 (95% CI: 2.0-3.5) and 1.7 (95% CI: 1.1-2.6) times more frequent on hot days compared to normal summer days. Low household income and disability increased risk of heat-related EDP (AOR = 3.20; 95% CI: 1.16-8.81 and AOR = 2.66; 95% CI: 1.15-6.14 respectively) and health events (AOR = 2.84; 95% CI: 1.06-7.64 and AOR = 2.51; 95% CI: 1.13-5.61 respectively). High social participation was a protective factor of heat-related EDP (AOR = 0.05; 95% CI: 0.01-0.20) and health events (AOR = 0.04; 95% CI: 0.01-0.18). Older adults presenting ≥6 OAHVI factors out of 9 were 7-8 times more at risk of heat-related EDP (OR = 7.40; 95% CI: 1.51-36.19) and health events (OR = 7.77; 95% CI: 1.63-37.20) compared to participants having 0-1 factor. Social participation, reduced autonomy and low income were predictors of HRHO. The OAHVI, also a strong predictor, should help clinicians identify high-risk elderly patients.

Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F2α

PubMed Central

NOGUCHI, Michiko; IKEDO, Tomonobu; KAWAGUCHI, Hiroaki; TANIMOTO, Akihide

2016-01-01

The induction of pseudopregnancy by the exogenous administration of estradiol dipropionate (EDP) was investigated in cyclic Microminipigs (MMpigs) and the effects of exogenous administration of prostaglandin (PG) F2α on estrus exhibition were assessed in pseudopregnant MMpigs. In experiment 1, ovariectomized MMpigs were given a single intramuscular injection of 0.5, 1.5, or 2.5 mg of EDP. The estradiol-17β level at each of these doses was significantly higher 1 to 3 days after EDP administration than on the day of the injection. In experiment 2, animals were given 1.5 mg of EDP once at 9 to 12 days after the end of estrus (D0) and then no (1.5 mg × 1 group), one (D0 and D4; 1.5 mg × 2 group), or two (D0, D4 and D7; 1.5 mg × 3 group) additional treatments. The pseudopregnancy rate was significantly higher in the 1.5 mg × 3 than in the 1.5 mg × 1 group. In experiment 3, PGF2α was administered twice between 26 and 28 days after EDP treatment to five pseudopregnant gilts with a 24-h interval between the two injections. Estrus after PGF2α treatment and LH surge were observed in 100% and 80% pseudopregnant MMpigs, respectively. The interval from the day of the first PGF2α treatment to the onset of estrus was 6.5 ± 0.2 days. These results indicate that multiple EDP treatments are required for induction of pseudopregnancy in MMpigs and estrus exhibition can be controlled in MMpigs by treatment with EDP and PGF2α. PMID:27151362

Are Canadian clinicians providing consistent sport-related concussion management advice?

PubMed

Carson, James D; Rendely, Alexandra; Garel, Alisha; Meaney, Christopher; Stoller, Jacqueline; Kaicker, Jatin; Hayden, Leigh; Moineddin, Rahim; Frémont, Pierre

2016-06-01

To compare the knowledge and use of recommendations for the management of sport-related concussion (SRC) among sport and exercise medicine physicians (SEMPs) and emergency department physicians (EDPs) to assess the success of SRC knowledge transfer across Canada. A self-administered, multiple-choice survey accessed via e-mail by SEMPs and EDPs. The survey had been assessed for content validity. Canada. The survey was completed between May and July 2012 by SEMPs who had passed the diploma examination of the Canadian Academy of Sport and Exercise Medicine and by EDPs who did not hold this diploma. Knowledge and identification of sources of concussion management information, use of concussion diagnosis strategies, and whether physicians use common and consistent terminology when explaining cognitive rest strategies to patients after an SRC. There was a response rate of 28% (305 of 1085). The SEMP and EDP response rates were 41% (147 of 360) and 22% (158 of 725), respectively. Of the responses, 41% of EDPs and 3% of SEMPs were unaware of any consensus statements on concussion in sport; 74% of SEMPs used the Sport Concussion Assessment Tool, version 2 (SCAT2), "usually or always," whereas 88% of EDPs never used the SCAT2. When queried about how cognitive rest could best be achieved after an SRC, no consistent answer was documented. Differences and a lack of consistency in the implementation of recommendations for SRC patients were identified for SEMPs and EDPs. It appears that the SCAT2 is used more in the SEMP setting than in the emergency context. Further knowledge transfer efforts and research should address the barriers to achieving more consistent advice given by physicians who attend SRC patients. Copyright© the College of Family Physicians of Canada.

Ruthenium nano-oxide layer in CoFe-Ru-CoFe trilayer system: An x-ray reflectivity study

NASA Astrophysics Data System (ADS)

Asgharizadeh, S.; Sutton, M.; Altounian, Z.; Mao, M.; Lee, C. L.

2008-05-01

A grazing incidence x-ray reflectivity technique is used to determine the electron density profile as a function of depth in CoFe-Ru-CoFe and CoFe-Ru nano-oxide layer (NOL)-CoFe trilayers. Four trilayers with ruthenium thicknesses of 8, 8.5, and 9Å and one with Ru 8.5Å NOL, prepared by a dc planetary sputtering system, were investigated. For all samples, the electron density profile (EDP) shows a central peak that is related to the Ru layer. Natural oxidation in all of the samples introduces a graded EDP of the top CoFe layers, which decreases gradually to zero. The large surface resistivity of Ru 8.5Å NOL as compared to Ru 8.5Å is related to the remarkable difference between their EDPs. EDP changes have also been investigated in Ru NOL trilayers after annealing at 280°C. The Ru phase in the EDP was observed to confirm the thermal stability of the spacer layer after annealing.

EDP Sciences and A&A: partnering to providing services to support the scientific community

NASA Astrophysics Data System (ADS)

Henri, Agnes

2015-08-01

Scholarly publishing is no longer about simply producing and packaging articles and sending out to subscribers. To be successful, as well as being global and digital, Publishers and their journals need to be fully engaged with their stakeholders (authors, readers, funders, libraries etc), and constantly developing new products and services to support their needs in the ever-changing environment that we work in.Astronomy & Astrophysics (A&A) is a high quality, major international Journal that belongs to the astronomical communities of a consortium of European and South American countries supported by ESO who sponsor the journal. EDP Sciences is a non-profit publisher belonging to several learned societies and is appointed by ESO to publish the journal.Over the last decade, as well as publishing the results of worldwide astronomical and astrophysical research, A&A and EDP Sciences have worked in partnership to develop a wide range of services for the authors and readers of A&A:- A specialist language editing service: to provide a clear and excellent level of English ensuring full understanding of the high-quality science.- A flexible and progressive Open Access Policy including Gold and Green options and strong links with arXiv.- Enriched articles: authors are able to enhance their articles using a wide range of rich media such as 3D models, videos and animations.Multiple publishing formats: allowing readers to browse articles on multiple devices including eReaders and Kindles.- “Scientific Writing for Young Astronomers”: In 2008 EDP Sciences and A&A set up the Scientific Writing for Young Astronomers (SWYA) School with the objective to teach early PhD Students how write correct and efficient scientific papers for different mediums (journals, proceedings, thesis manuscripts, etc.).

Distributed Optimal Dispatch of Distributed Energy Resources Over Lossy Communication Networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Junfeng; Yang, Tao; Wu, Di

In this paper, we consider the economic dispatch problem (EDP), where a cost function that is assumed to be strictly convex is assigned to each of distributed energy resources (DERs), over packet dropping networks. The goal of a standard EDP is to minimize the total generation cost while meeting total demand and satisfying individual generator output limit. We propose a distributed algorithm for solving the EDP over networks. The proposed algorithm is resilient against packet drops over communication links. Under the assumption that the underlying communication network is strongly connected with a positive probability and the packet drops are independentmore » and identically distributed (i.i.d.), we show that the proposed algorithm is able to solve the EDP. Numerical simulation results are used to validate and illustrate the main results of the paper.« less

Magnetospheric access of solar particles and the configuration of the distant geomagnetic field, volume 2. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Evans, L. C.

1972-01-01

A summary is provided of all proton events observed with OGO/4 and observed flux profiles for several events. Pertinent data are indicated relating to the orientation of the interplanetary magnetic field. The events whose profiles are presented are divided into three classes: EDP events (normally associated with co-rotating features), solar flare events, and events having characteristics of both EDP events and flare events (class C events). A description of these classes of events and the criteria used to distinguish between EDP events and flare events are discussed. In addition, the 1 December 1967 EDP event and the 2 November 1967 solar flare event are discussed in some detail. Accompanying the profiles of each event is a brief list of notable observational features of the event. Events are presented chronologically.

X-ray reflectivity of ruthenium nano-oxide layer in a CoFe-Ru-CoFe trilayer system

NASA Astrophysics Data System (ADS)

Asghari Zadeh, Saeid; Sutton, Mark; Altonian, Zaven; Mao, Ming; Lee, Chih-Ling

2006-03-01

A grazing incidence X-ray reflectivity technique is used to determine electron density profile(EDP) as a function of depth in CoFe-Ru-CoFe and CoFe-Ru nano oxide layer(NOL)-CoFe trilayers. Four trilayers with ruthenium thicknesses of 8,8.5 and 9 å.08cm and one with Ru8.5.05cmå.05cmNOL, prepared by a dc planetary sputtering system, were investigated. For all samples, EDP shows a central peak which is related to the Ru layer. Natural oxidation in all samples introduces a graded EDP of the top CoFe layer that decreases gradually to zero. The large surface resistivity of Ru8.5 å.05cm NOL compared to Ru 8.5å.08cm can be related to the remarkable difference between their EDP.

Epoxy fatty acids mediate analgesia in murine diabetic neuropathy.

PubMed

Wagner, K; Lee, K S S; Yang, J; Hammock, B D

2017-03-01

Neuropathic pain is a debilitating condition with no adequate therapy. The health benefits of omega-3 fatty acids are established, however, the role of docosahexaenoic acid (DHA) in limiting pain has only recently been described and the mechanisms of this action remain unknown. DHA is metabolized into epoxydocosapentanoic acids (EDPs) via cytochrome P450 (CYP450) enzymes which are substrates for the soluble epoxide hydrolase (sEH) enzyme. Here, we tested several hypotheses; first, that the antinociceptive action of DHA is mediated by the EDPs. Second, based on evidence that DHA and CYP450 metabolites elicit analgesia through opioid signalling, we investigated this as a possible mechanism of action. Third, we tested whether the analgesia mediated by epoxy fatty acids had similar rewarding effects as opioid analgesics. We tested diabetic neuropathic wild-type and sEH null mice in a conditioned place preference assay for their response to EDPs, sEHI and antagonism of these treatments with naloxone, a mu-opioid receptor antagonist. The EDPs and sEH inhibitors were efficacious against chronic pain, and naloxone antagonized the action of both EDPs and sEH inhibitors. Despite this antagonism, the sEH inhibitors lacked reward side effects differing from opioids. The EpFA are analgesic against chronic pain differing from opioids which have limited efficacy in chronic conditions. EDPs and sEHI mediate analgesia in modelled chronic pain and this analgesia is blocked by naloxone. However, unlike opioids, sEHI are highly effective in neuropathic pain models and importantly lack rewarding side effects. © 2016 European Pain Federation - EFIC®.

Earthdata Developer Portal poster

NASA Astrophysics Data System (ADS)

Plofchan, P.

2016-12-01

A common theme at community conferences in the Earth science domain is the need for more integration with related services, clearer documentation for services available, and a general simplification of what it takes to leverage existing tools so that setup and administration time can be minimized and time spent researching can be maximized. NASA's Earthdata Developer Portal (EDP) is the newly-created central location for documentation related to interacting with services offered by the EOSDIS community. The EDP will provide technical documentation for APIs, process documentation that provides real-world examples of how to use existing APIs in the real world, release notes for applications and services so that the entire community can stay up to date on recent updates, and best practice suggestions to improve implementation of both front-end and back-end services. Application and service owners will own their documentation while the EDP will ingest the documentation, serve it up in an interface using both industry standard tools, such as Swagger, and custom "adapters". The content is then styled to ensure consistency with other documentation found throughout the site and will be made searchable from a single location. "Getting Started" paths will also provide those users new to the space a simple path to follow to perform common tasks such as "searching and getting data" or "hosting an application on the Earthdata platform."

Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from “MANOSROI III” Database

PubMed Central

Manosroi, Aranya; Tangjai, Theeraphong; Chankhampan, Charinya; Manosroi, Worapaka; Najarut, Yaravee; Kitdamrongtham, Worapong

2017-01-01

Seven plants in the top rank were selected from the “MANOSROI III” database using the two Thai keywords which meant impotence and sexual tonic. Boesenbergia rotunda (L.) Mansf. extract [EDP1-001(1)] gave the highest PDE inhibition activity of 4.36-fold sildenafil, a standard anti-impotence drug. Plumbago indica Linn. extract [EDP2-001(1)] exhibited the highest NO release stimulation activity of 666.85% which was 1.50-fold acetylcholine, a standard drug. Most selected plant extracts were nontoxic to EA.hy926 cells at 1.0 mg/mL. EDP1-001(1) exhibited the LD50 value of acute oral toxicity in male ICR mice of over 5,000 mg/kg body weight. EDP1-001(1) also indicated the improvement of sexual behaviors in the paroxetine-induced sexual dysfunction male mice with the evaluation of number of courtships (NC), mount frequency (MF), intromission frequency (IF), and ejaculatory frequency (EF) at 87.67 ± 6.17, 121.00 ± 23.50, 36.00 ± 3.21, and 13.67 ± 2.96 which were 2.63-, 1.27-, 0.53-, and 0.62-fold sildenafil-treated mice at day 14 of the treatments, respectively. The present study has not only confirmed the traditional use of Thai plants for the treatment of ED but also indicated the potential and application of the “MANOSROI III” database for Thai plant selection to be developed as ED food supplements. PMID:28811831

The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase-1, -2, -9 and tissue inhibitor of metalloproteinases-1, -2, -3 expression in human retinal pigment epithelial cells.

PubMed

Dorecka, Mariola; Francuz, Tomasz; Garczorz, Wojciech; Siemianowicz, Krzysztof; Romaniuk, Wanda

2014-01-01

Hyperglycemia and increased concentrations of elastin degradation products (EDPs) are common findings in patients with diabetes, atherosclerosis and hypertension. The aim of this study was to assess the influence of high glucose, EDPs and atorvastatin on MMP-1, MMP-2, MMP-9 and TIMP1-3 gene expression in human retinal pigment epithelial cells (HRPE) in vitro. HRPE were cultured for 24 hours with the substances being tested (glucose, EDPs), alone or in combination. Additionally, the cells were treated with atorvastatin in two different concentrations (1 or 10 μM). After incubation, total cellular RNA was extracted and used for gene expression evaluation. Gene expression was measured using the real-time RT-PCR technique. Glucose, EDPs and atorvastatin had no impact on TIMP-1 and TIMP-3 expression. HRPE cells treated with glucose or EDPs with the addition of atorvastatin had a statistically significant decrease of TIMP-2 expression; glucose alone decreased MMP-1 expression. Atorvastatin decreased expression of all assessed genes, except TIMP-1 and TIMP-3 in a dose-dependent manner. Our results confirm the importance of MMPs and TIMPs in retinal vascular biology. Atorvastatin-induced MMPs gene expression can deeply affect extracellular matrix turnover, which may play an important role in the progression of ocular diseases.

ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.

PubMed

Wang, Weicang; Yang, Jun; Nimiya, Yoshiki; Lee, Kin Sing Stephen; Sanidad, Katherine; Qi, Weipeng; Sukamtoh, Elvira; Park, Yeonhwa; Liu, Zhenhua; Zhang, Guodong

2017-10-01

Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed that dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice. Notably, we found that dietary feeding of ω-3 PUFAs significantly increased levels of epoxydocosapentaenoic acids (EDPs, metabolites of ω-3 PUFA produced by cytochrome P450 enzymes) in plasma and tumor tissue of the treated mice. We further showed that systematic treatment with EDPs (dose=0.5 mg/kg per day) suppressed MC38 tumor growth in mice, with reduced expressions of pro-oncogenic genes such as C-myc, Axin2, and C-jun in tumor tissues. Together, these results support that formation of EDPs might contribute to the anti-colorectal cancer effects of ω-3 PUFAs. Copyright © 2017 Elsevier Inc. All rights reserved.

Current management practices and interventions prioritised as part of a nationwide mastitis control plan

PubMed Central

Bradley, A. J.; Breen, J. E.; Hudson, C. D.; Green, M. J.

2016-01-01

The objectives of this study were to report performance and management data taken from a sample of UK dairy farms that have participated in the Agriculture and Horticulture Development Board Dairy Mastitis Control Plan (DMCP) and to identify important mastitis prevention practices that are not currently widely implemented. A total of 234 UK dairy herds were included in the study from which farm management and udder health data were collected. Herds were grouped according to their mastitis epidemiology and could be classed as (i) environmental dry period (EDP) (i.e. environmental pathogen with majority of infections being acquired during the dry period), (ii) environmental lactation (EL), (iii) contagious dry period (CDP) or (iv) contagious lactation (CL). The results of this study showed that many mastitis-related management practices that are generally considered to be important were not widely performed. A better understanding of those practices not widely adopted by UK dairy farmers at present may aid practitioners in identifying and overcoming potential barriers to improved mastitis control. PMID:26966249

41 CFR 101-26.508-2 - Requisitioning data processing tape not available from Federal Supply Schedule contracts.

Code of Federal Regulations, 2013 CFR

2013-07-01

... contracts. (a) Requisitions for types of EDP tape and instrumentation tape (wide and intermediate band... is located. (b) Requisitions for all types of EDP tape and instrumentation tape (wide and... and $5,000 for instrumentation tape. However, regardless of the amount involved (including...

Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating M1/M2 macrophage polarization1

PubMed Central

Dale, Matthew A; Xiong, Wanfen; Carson, Jeffrey S; Suh, Melissa K; Karpisek, Andrew D.; Meisinger, Trevor M.; Casale, George P.; Baxter, B. Timothy

2016-01-01

Abdominal aortic aneurysm (AAA) is a dynamic vascular disease characterized by inflammatory cell invasion and extracellular matrix (ECM) degradation. Damage to elastin in the ECM results in release of elastin-derived peptides (EDPs), which are chemotactic for inflammatory cells such as monocytes. Their effect on macrophage polarization is less well known. Pro-inflammatory M1 macrophages initially are recruited to sites of injury but, if their effects are prolonged, they can lead to chronic inflammation that prevents normal tissue repair. Conversely, anti-inflammatory M2 macrophages reduce inflammation and aid in wound healing. Thus, a proper M1/M2 ratio is vital for tissue homeostasis. AAA tissue reveals a high M1/M2 ratio where pro-inflammatory cells and their associated markers dominate. In the present study, in vitro treatment of bone marrow-derived macrophages with EDPs induced M1 macrophage polarization. By using C57Bl/6 mice, antibody-mediated neutralization of EDPs reduced aortic dilation, matrix metalloproteinase activity, and pro-inflammatory cytokine expression at early and late time points after aneurysm induction. Furthermore, direct manipulation of the M1/M2 balance altered aortic dilation. Injection of M2 polarized macrophages reduced aortic dilation after aneurysm induction. EDPs promoted a pro-inflammatory environment in aortic tissue by inducing M1 polarization and neutralization of EDPs attenuated aortic dilation. The M1/M2 imbalance is vital to aneurysm formation. PMID:27183603

Antigen-antibody interaction. The immunodominant region of EDP208 pili.

PubMed

Worobec, E A; Paranchych, W; Parker, J M; Taneja, A K; Hodges, R S

1985-01-25

The EDP208 pilus contains a major antigenic determinant in the N-terminal dodecapeptide, as shown by E. A. Worobec, A. K. Taneja, R. S. Hodges, and W. Paranchych ((1983) J. Bacteriol. 153, 955-961). This peptide was chemically synthesized, coupled to bovine serum albumin with N-hydroxysuccinimidyl p-azido-benzoate, and used in immunoblot and enzyme-linked immunosorbent assays to show it was capable of reacting with anti-EDP208 pilus antibodies. Antibodies raised against the synthetic peptide conjugate were also capable of reacting with whole pili in these assays. To further examine the specific residues responsible for the antigenicity of this site, several peptide analogs were chemically synthesized. The relative affinity of these peptides for anti-EDP208 pilus antibodies was determined by a competitive enzyme-linked immunosorbent assay using the Fab fragment of anti-EDP208 pilus immunoglobulin G. From these results we established that the antigenic region of this peptide was the N-terminal pentapeptide, N-acetyl-Thr-Asp-Leu-Leu-Ala, and the key residues responsible for the antibody-antigen interaction are the N-acetyl-Thr1, Leu3, and Leu4. Hydrophobic interactions involving the methyl of the acetyl group and the leucine side chains make the largest contributions to the antigen-antibody interaction, while a lesser contribution is made by the Thr1 hydroxyl. The side chains of Asp2 and Ala5 contribute only weakly to the stabilization of the antigen-antibody complex.

Brain networks during free viewing of complex erotic movie: new insights on psychogenic erectile dysfunction.

PubMed

Cera, Nicoletta; Di Pierro, Ezio Domenico; Ferretti, Antonio; Tartaro, Armando; Romani, Gian Luca; Perrucci, Mauro Gianni

2014-01-01

Psychogenic erectile dysfunction (ED) is defined as a male sexual dysfunction characterized by a persistent or recurrent inability to attain adequate penile erection due predominantly or exclusively to psychological or interpersonal factors. Previous fMRI studies were based on the common occurrence in the male sexual behaviour represented by the sexual arousal and penile erection related to viewing of erotic movies. However, there is no experimental evidence of altered brain networks in psychogenic ED patients (EDp). Some studies showed that fMRI activity collected during non sexual movie viewing can be analyzed in a reliable manner with independent component analysis (ICA) and that the resulting brain networks are consistent with previous resting state neuroimaging studies. In the present study, we investigated the modification of the brain networks in EDp compared to healthy controls (HC), using whole-brain fMRI during free viewing of an erotic video clip. Sixteen EDp and nineteen HC were recruited after RigiScan evaluation, psychiatric, and general medical evaluations. The performed ICA showed that visual network (VN), default-mode network (DMN), fronto-parietal network (FPN) and salience network (SN) were spatially consistent across EDp and HC. However, between-group differences in functional connectivity were observed in the DMN and in the SN. In the DMN, EDp showed decreased connectivity values in the inferior parietal lobes, posterior cingulate cortex and medial prefrontal cortex, whereas in the SN decreased and increased connectivity was observed in the right insula and in the anterior cingulate cortex respectively. The decreased levels of intrinsic functional connectivity principally involved the subsystem of DMN relevant for the self relevant mental simulation that concerns remembering of past experiences, thinking to the future and conceiving the viewpoint of the other's actions. Moreover, the between group differences in the SN nodes suggested a decreased recognition of autonomical and sexual arousal changes in EDp.

Brain Networks during Free Viewing of Complex Erotic Movie: New Insights on Psychogenic Erectile Dysfunction

PubMed Central

Cera, Nicoletta; Di Pierro, Ezio Domenico; Ferretti, Antonio; Tartaro, Armando; Romani, Gian Luca; Perrucci, Mauro Gianni

2014-01-01

Psychogenic erectile dysfunction (ED) is defined as a male sexual dysfunction characterized by a persistent or recurrent inability to attain adequate penile erection due predominantly or exclusively to psychological or interpersonal factors. Previous fMRI studies were based on the common occurrence in the male sexual behaviour represented by the sexual arousal and penile erection related to viewing of erotic movies. However, there is no experimental evidence of altered brain networks in psychogenic ED patients (EDp). Some studies showed that fMRI activity collected during non sexual movie viewing can be analyzed in a reliable manner with independent component analysis (ICA) and that the resulting brain networks are consistent with previous resting state neuroimaging studies. In the present study, we investigated the modification of the brain networks in EDp compared to healthy controls (HC), using whole-brain fMRI during free viewing of an erotic video clip. Sixteen EDp and nineteen HC were recruited after RigiScan evaluation, psychiatric, and general medical evaluations. The performed ICA showed that visual network (VN), default-mode network (DMN), fronto-parietal network (FPN) and salience network (SN) were spatially consistent across EDp and HC. However, between-group differences in functional connectivity were observed in the DMN and in the SN. In the DMN, EDp showed decreased connectivity values in the inferior parietal lobes, posterior cingulate cortex and medial prefrontal cortex, whereas in the SN decreased and increased connectivity was observed in the right insula and in the anterior cingulate cortex respectively. The decreased levels of intrinsic functional connectivity principally involved the subsystem of DMN relevant for the self relevant mental simulation that concerns remembering of past experiences, thinking to the future and conceiving the viewpoint of the other’s actions. Moreover, the between group differences in the SN nodes suggested a decreased recognition of autonomical and sexual arousal changes in EDp. PMID:25126947

Inferring Polar Ion Outflows from Topside Ionograms

NASA Astrophysics Data System (ADS)

Sojka, J. J.; Rice, D. D.; Eccles, V.; Schunk, R. W.; David, M.; Benson, R. F.; James, H. G.

2017-12-01

The high-latitude topside ionosphere is dominated by O+ ions from the F-region peak around 300 km to over 1000 km altitude. The O+ profile shape provides information on the thermal structure, field aligned plasma dynamics, and outflows into the magnetosphere. Topside electron density profiles (EDP) are either obtained from topside sounders or Incoherent Scatter Radars. There is a large archive of topside sounder ionograms and hand scaled EDPs from the Alouette and ISIS satellites between 1962 and 1990. Recent NASA data enhancement efforts have augmented these EDP archives by producing digital topside ionograms both from the 7-track analog telemetry tapes and from 35 mm topside film ionograms. Rice et al [2017] in their 35 mm ionogram recovery emphasized high latitude ionograms taken during disturbed conditions. The figure below contrasts ISIS-II EDPs extracted from 35 mm films before and during a major storm (Dst -200nT) on 9 April 1972 (left panel: quiet period before the storm; right panel: during the peak of the storm). Both satellite passes used for these EDPs were centered on the Resolute Bay location that in 1972 was close to the magnetic pole. They begin at auroral latitudes around 2100 MLT and end on the dayside around 0900MLT. We will present results of how ionospheric models replicate both the quiet and disturbed conditions shown in the figure. Three types of models will be contrasted: an empirical ionosphere (IRI), a physics based ionospheric model (TDIM), and a fluid-based polar-wind model (PW). During the storm pass, when it is expected that substantial heating is present, the ISIS-II topside EDPs provide severe constraints on the usage of these models. These constraints enable estimates of the outflow fluxes as well as the heating that has occurred. The comparisons with the empirical model establish how well the pre-storm topside is modeled and identifies the challenges as the storm magnitude increases. The physics-based TDIM does have storm drivers but is limited in how the 800 km topside boundary is set. In contrast, the polar wind model extends out to many Earth radii and, hence, physically handles ionospheric heating and ion outflows during storms. These topside EDP data will provide a means to establish the sensitivity of various ionospheric heating mechanisms that drive the ion outflow.

A Distributed Algorithm for Economic Dispatch Over Time-Varying Directed Networks With Delays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Tao; Lu, Jie; Wu, Di

In power system operation, economic dispatch problem (EDP) is designed to minimize the total generation cost while meeting the demand and satisfying generator capacity limits. This paper proposes an algorithm based on the gradient-push method to solve the EDP in a distributed manner over communication networks potentially with time-varying topologies and communication delays. It has been shown that the proposed method is guaranteed to solve the EDP if the time-varying directed communication network is uniformly jointly strongly connected. Moreover, the proposed algorithm is also able to handle arbitrarily large but bounded time delays on communication links. Numerical simulations are usedmore » to illustrate and validate the proposed algorithm.« less

Enzymatic Enantioselective Decarboxylative Protonation of Heteroaryl Malonates

PubMed Central

Lewin, Ross; Goodall, Mark; Thompson, Mark L; Leigh, James; Breuer, Michael; Baldenius, Kai; Micklefield, Jason

2015-01-01

The enzyme aryl/alkenyl malonate decarboxylase (AMDase) catalyses the enantioselective decarboxylative protonation (EDP) of a range of disubstituted malonic acids to give homochiral carboxylic acids that are valuable synthetic intermediates. AMDase exhibits a number of advantages over the non-enzymatic EDP methods developed to date including higher enantioselectivity and more environmentally benign reaction conditions. In this report, AMDase and engineered variants have been used to produce a range of enantioenriched heteroaromatic α-hydroxycarboxylic acids, including pharmaceutical precursors, from readily accessible α-hydroxymalonates. The enzymatic method described here represents an improvement upon existing synthetic chemistry methods that have been used to produce similar compounds. The relationship between the structural features of these new substrates and the kinetics associated with their enzymatic decarboxylation is explored, which offers further insight into the mechanism of AMDase. PMID:25766433

Status of Galileo interim radiation electron model

NASA Technical Reports Server (NTRS)

Garrett, H. B.; Jun, I.; Ratliff, J. M.; Evans, R. W.; Clough, G. A.; McEntire, R. W.

2003-01-01

Measurements of the high energy, omni-directional electron environment by the Galileo spacecraft Energetic Particle Detector (EDP) were used to develop a new model of Jupiter's trapped electron radiation in the jovian equatorial plane for the range 8 to 16 Jupiter radii.

Localization of the major antigenic determinant of EDP208 pili at the N-terminus of the pilus protein.

PubMed Central

Worobec, E A; Taneja, A K; Hodges, R S; Paranchych, W

1983-01-01

Trypsin digestion of pilin monomers from EDP208 conjugative pili causes cleavage of Lys12 to yield an N-terminal dodecapeptide, ET1 (Mr approximately equal to 1,500), and the remaining C-terminal fragment, ER (Mr approximately equal to 10,000). Using the amino acid sequence for ET1 provided by Frost et al. (J. Bacteriol. 153:950-954), we synthesized the N-terminal dodecapeptide chemically, conjugated it to bovine serum albumin, and subjected it to immunological studies. Antisera prepared against intact EDP208 pili as well as against the synthetic ET1-BSA conjugate were used in experiments involving an enzyme-linked immunosorbant assay and electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to nitrocellulose sheets. Both experimental approaches showed strong reactivity between the synthetic dodecapeptide and antiserum raised against whole pili. It was also found that antiserum raised against the synthetic peptide was reactive against intact pilus protein, indicating that the N-terminal dodecapeptide is an important antigenic determinant of the EDP208 pilus protein. Additional studies showed that the C-terminal fragment, ER, may contain one or two additional antigenic sites. Images PMID:6185467

Localization of the major antigenic determinant of EDP208 pili at the N-terminus of the pilus protein.

PubMed

Worobec, E A; Taneja, A K; Hodges, R S; Paranchych, W

1983-02-01

Trypsin digestion of pilin monomers from EDP208 conjugative pili causes cleavage of Lys12 to yield an N-terminal dodecapeptide, ET1 (Mr approximately equal to 1,500), and the remaining C-terminal fragment, ER (Mr approximately equal to 10,000). Using the amino acid sequence for ET1 provided by Frost et al. (J. Bacteriol. 153:950-954), we synthesized the N-terminal dodecapeptide chemically, conjugated it to bovine serum albumin, and subjected it to immunological studies. Antisera prepared against intact EDP208 pili as well as against the synthetic ET1-BSA conjugate were used in experiments involving an enzyme-linked immunosorbant assay and electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to nitrocellulose sheets. Both experimental approaches showed strong reactivity between the synthetic dodecapeptide and antiserum raised against whole pili. It was also found that antiserum raised against the synthetic peptide was reactive against intact pilus protein, indicating that the N-terminal dodecapeptide is an important antigenic determinant of the EDP208 pilus protein. Additional studies showed that the C-terminal fragment, ER, may contain one or two additional antigenic sites.

Russian University Education in Nuclear Safeguards and Security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, Cristen L.; Kryuchkov, Eduard F.; Geraskin, Nikolay I.

2009-03-15

As safeguards and security (S&S) systems are installed and upgraded in nuclear facilities throughout Russia, it becomes increasingly important to develop mechanisms for educating future Russian nuclear scientists and engineers in the technologies and methodologies of physical protection (PP) and nuclear material control and accounting (MC&A). As part of the U.S. Department of Energy’s (DOE) program to secure nuclear materials in Russia, the Education Project supports technical S&S degree programs at key Russian universities and nonproliferation education initiatives throughout the Russian Federation that are necessary to achieve the overall objective of fostering qualified and vigilant Russian S&S personnel. The Educationmore » Project supports major educational degree programs at the Moscow Engineering Physics Institute (MEPhI) and Tomsk Polytechnic University (TPU). The S&S Graduate Program is available only at MEPhI and is the world’s first S&S degree program. Ten classes of students have graduated with a total of 79 Masters Degrees as of early 2009. At least 84% of the graduates over the ten years are still working in the S&S field. Most work at government agencies or research organizations, and some are pursuing their PhD. A 5½ year Engineering Degree Program (EDP) in S&S is currently under development at MEPhI and TPU. The EDP is more tailored to the needs of nuclear facilities. The program’s first students (14) graduated from MEPhI in February 2007. Similar-sized classes are graduating from MEPhI each February. All of the EDP graduates are working in the S&S field, many at nuclear facilities. TPU also established an EDP and graduated its first class of approximately 18 students in February 2009. For each of these degree programs, the American project team works with MEPhI and TPU to develop appropriate curriculum, identify and acquire various training aids, develop and publish textbooks, and strengthen instructor skills. The project has also supported the instruction of policy-oriented nonproliferation courses at various Russian universities. These courses are targeted towards future workers in the nuclear field to help build an effective nonproliferation awareness within the nuclear complex. A long-range goal of this project is to assist the educational programs at MEPhI and TPU in becoming self-sustainable and therefore able to maintain the three degree programs without DOE support. This paper describes current development of these education programs and new initiatives. The paper also describes general nonproliferation education activities supported by DOE that complement the more technical S&S degree programs.« less

On the possible use of radio occultation middle latitude electron density profiles to retrieve thermospheric parameters

NASA Astrophysics Data System (ADS)

Mikhailov, Andrei V.; Belehaki, Anna; Perrone, Loredanna; Zolesi, Bruno; Tsagouri, Ioanna

2014-04-01

This paper investigates possible use of middle latitude daytime COSMIC and CHAMP ionospheric radio occultation (IRO) electron density profiles (EDPs) to retrieve thermospheric parameters, based on the Mikhailov et al. (2012) method. The aim of this investigation is to assess the applicability of this type of observations for the routine implementation of the method. According to the results extracted from the analysis presented here, about half of COSMIC IRO EDP observed under solar minimum (2007-2008) conditions gave neutral gas density with an inaccuracy close to the declared absolute inaccuracy ±(10-15)% of CHAMP observations, with the results being better than the empirical models JB-2008 and MSISE-00 provide. For the other half of IRO EDP, either the solution provided by the method had to be rejected due to insufficient accuracy or no solution could be obtained. For these cases, the parameters foF2 and hmF2 extracted from the corresponding IRO profiles have been found to be inconsistent with the classic mid-latitude daytime F2-layer formalism that the method relies on, and they are incompatible with the general trend provided by the IRI model. For solar maximum conditions (2002) the method was tested with IRO EDP from CHAMP and it is indicated that its performance is quite stable in the sense that a solution could be obtained for all the cases analyzed here. However available CHAMP EDP are confined by ~ 400 km in altitude and this might be the reason for the 20% bias of the retrieved densities toward larger values in respect to the observed densities. IRO observations up to 600 km under solar maximum are required to confirm the exact performance of the method.

Analysis of Endocrine Disrupting Pesticides by Capillary GC with Mass Spectrometric Detection

PubMed Central

Matisová, Eva; Hrouzková, Svetlana

2012-01-01

Endocrine disrupting chemicals, among them many pesticides, alter the normal functioning of the endocrine system of both wildlife and humans at very low concentration levels. Therefore, the importance of method development for their analysis in food and the environment is increasing. This also covers contributions in the field of ultra-trace analysis of multicomponent mixtures of organic pollutants in complex matrices. With this fact conventional capillary gas chromatography (CGC) and fast CGC with mass spectrometric detection (MS) has acquired a real importance in the analysis of endocrine disrupting pesticide (EDP) residues. This paper provides an overview of GC methods, including sample preparation steps, for analysis of EDPs in a variety of matrices at ultra-trace concentration levels. Emphasis is put on separation method, mode of MS detection and ionization and obtained limits of detection and quantification. Analysis time is one of the most important aspects that should be considered in the choice of analytical methods for routine analysis. Therefore, the benefits of developed fast GC methods are important. PMID:23202677

SU-F-T-322: A Comparison of Two Si Detectors for in Vivo Dosimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Talarico, O; Krylova, T; Lebedenko, I

Purpose: To compare two types of semiconductor detectors for in vivo dosimetry by their dependence from various parameters in different conditions. Methods: QED yellow (Sun Nuclear) and EDP (Scanditronix) Si detectors were radiated by a Varian Clinac 2300 ix with 6 and 18 MV energies. 10 cm thickness water equivalent phantom consisted of 30×30 cm{sup 2} squared plates was used for experiments. Dose dependencies for different beam angles (0 – 180°), field size (3–40 cm), dose (50 – 300 MU), and dose rates (50 – 300 MU/min) were obtained and calibrated with Standard Farmer chamber (PTW). Results: Reproducibility, linearity, dosemore » rate, angular dependence, and field size dependence were obtained for QED and EDP. They show no dose-rate dependence in available clinical dose rate range (100–600 MU/min). Both diodes have linear dependence with increasing the dose. Therefore even in case of high radiation therapy (including total body irradiation) it is not necessary to apply an additional correction during in vivo dosimetry. The diodes have different behavior for angular and field size dependencies. QED diode showed that dose value is stable for beam angles from 0 to 60°, for 60–180° correction factor has to be applied for each beam angle during in vivo measurements. For EDP diode dose value is sensitive to beam angle in whole range of angles. Conclusion: The study shows that QED diode is more suitable for in vivo dosimetry due to dose value independence from incident beam angle in the range 0–60°. There is no need in correction factors for increasing of dose and dose rate for both diodes. The next step will be to carry out measurements in non-standard conditions of total body irradiation. After this modeling of these experiments with Monte Carlo simulation for comparison calculated and obtained data is planned.« less

An ionospheric occultation inversion technique based on epoch difference

NASA Astrophysics Data System (ADS)

Lin, Jian; Xiong, Jing; Zhu, Fuying; Yang, Jian; Qiao, Xuejun

2013-09-01

Of the ionospheric radio occultation (IRO) electron density profile (EDP) retrievals, the Abel based calibrated TEC inversion (CTI) is the most widely used technique. In order to eliminate the contribution from the altitude above the RO satellite, it is necessary to utilize the calibrated TEC to retrieve the EDP, which introduces the error due to the coplanar assumption. In this paper, a new technique based on the epoch difference inversion (EDI) is firstly proposed to eliminate this error. The comparisons between CTI and EDI have been done, taking advantage of the simulated and real COSMIC data. The following conclusions can be drawn: the EDI technique can successfully retrieve the EDPs without non-occultation side measurements and shows better performance than the CTI method, especially for lower orbit mission; no matter which technique is used, the inversion results at the higher altitudes are better than those at the lower altitudes, which could be explained theoretically.

Portable, one-step, and rapid GMR biosensor platform with smartphone interface.

PubMed

Choi, Joohong; Gani, Adi Wijaya; Bechstein, Daniel J B; Lee, Jung-Rok; Utz, Paul J; Wang, Shan X

2016-11-15

Quantitative immunoassay tests in clinical laboratories require trained technicians, take hours to complete with multiple steps, and the instruments used are generally immobile-patient samples have to be sent in to the labs for analysis. This prevents quantitative immunoassay tests to be performed outside laboratory settings. A portable, quantitative immunoassay device will be valuable in rural and resource-limited areas, where access to healthcare is scarce or far away. We have invented Eigen Diagnosis Platform (EDP), a portable quantitative immunoassay platform based on Giant Magnetoresistance (GMR) biosensor technology. The platform does not require a trained technician to operate, and only requires one-step user involvement. It displays quantitative results in less than 15min after sample insertion, and each test costs less than US$4. The GMR biosensor employed in EDP is capable of detecting multiple biomarkers in one test, enabling a wide array of immune diagnostics to be performed simultaneously. In this paper, we describe the design of EDP, and demonstrate its capability. Multiplexed assay of human immunoglobulin G and M (IgG and IgM) antibodies with EDP achieves sensitivities down to 0.07 and 0.33 nanomolar, respectively. The platform will allow lab testing to be performed in remote areas, and open up applications of immunoassay testing in other non-clinical settings, such as home, school, and office. Copyright © 2016 Elsevier B.V. All rights reserved.

Disciplinary Literacies in an Engineering Club: Exploring Productive Communication and the Engineering Design Process

ERIC Educational Resources Information Center

Shanahan, Lynn E.; McVee, Mary B.; Slivestri, Katarina N.; Haq, Kate

2016-01-01

This conceptual article addresses the question: What are the disciplinary literacy practices surrounding the Engineering Design Process (EDP) at the elementary level? Recent attention has focused on developing science, technology, engineering, and math (STEM) skills for U.S. students. In the United States, the Next Generation Science Standards and…

Fortran Program for X-Ray Photoelectron Spectroscopy Data Reformatting

NASA Technical Reports Server (NTRS)

Abel, Phillip B.

1989-01-01

A FORTRAN program has been written for use on an IBM PC/XT or AT or compatible microcomputer (personal computer, PC) that converts a column of ASCII-format numbers into a binary-format file suitable for interactive analysis on a Digital Equipment Corporation (DEC) computer running the VGS-5000 Enhanced Data Processing (EDP) software package. The incompatible floating-point number representations of the two computers were compared, and a subroutine was created to correctly store floating-point numbers on the IBM PC, which can be directly read by the DEC computer. Any file transfer protocol having provision for binary data can be used to transmit the resulting file from the PC to the DEC machine. The data file header required by the EDP programs for an x ray photoelectron spectrum is also written to the file. The user is prompted for the relevant experimental parameters, which are then properly coded into the format used internally by all of the VGS-5000 series EDP packages.

Pros and cons of rotating ground motion records to fault-normal/parallel directions for response history analysis of buildings

USGS Publications Warehouse

Kalkan, Erol; Kwong, Neal S.

2014-01-01

According to the regulatory building codes in the United States (e.g., 2010 California Building Code), at least two horizontal ground motion components are required for three-dimensional (3D) response history analysis (RHA) of building structures. For sites within 5 km of an active fault, these records should be rotated to fault-normal/fault-parallel (FN/FP) directions, and two RHAs should be performed separately (when FN and then FP are aligned with the transverse direction of the structural axes). It is assumed that this approach will lead to two sets of responses that envelope the range of possible responses over all nonredundant rotation angles. This assumption is examined here, for the first time, using a 3D computer model of a six-story reinforced-concrete instrumented building subjected to an ensemble of bidirectional near-fault ground motions. Peak values of engineering demand parameters (EDPs) were computed for rotation angles ranging from 0 through 180° to quantify the difference between peak values of EDPs over all rotation angles and those due to FN/FP direction rotated motions. It is demonstrated that rotating ground motions to FN/FP directions (1) does not always lead to the maximum responses over all angles, (2) does not always envelope the range of possible responses, and (3) does not provide maximum responses for all EDPs simultaneously even if it provides a maximum response for a specific EDP.

Management Information System for Vocational Education. MISVE Technical Description. Research and Development Series No. 127E.

ERIC Educational Resources Information Center

Hulse, Ira; And Others

One of six documents describing the Management Information System for Vocational Education (MISVE), this document is intended for MISVE managers and electronic data processing (EDP) operations staff who would be responsible for the implementation and maintenance of the MISVE on the computer. (MISVE was designed to provide users with an advanced…

Combination of Entner-Doudoroff Pathway with MEP Increases Isoprene Production in Engineered Escherichia coli

PubMed Central

Liu, Huaiwei; Sun, Yuanzhang; Ramos, Kristine Rose M.; Nisola, Grace M.; Valdehuesa, Kris Niño G.; Lee, Won–Keun; Park, Si Jae; Chung, Wook-Jin

2013-01-01

Embden-Meyerhof pathway (EMP) in tandem with 2-C-methyl-D-erythritol 4-phosphate pathway (MEP) is commonly used for isoprenoid biosynthesis in E. coli. However, this combination has limitations as EMP generates an imbalanced distribution of pyruvate and glyceraldehyde-3-phosphate (G3P). Herein, four glycolytic pathways—EMP, Entner-Doudoroff Pathway (EDP), Pentose Phosphate Pathway (PPP) and Dahms pathway were tested as MEP feeding modules for isoprene production. Results revealed the highest isoprene production from EDP containing modules, wherein pyruvate and G3P were generated simultaneously; isoprene titer and yield were more than three and six times higher than those of the EMP module, respectively. Additionally, the PPP module that generates G3P prior to pyruvate was significantly more effective than the Dahms pathway, in which pyruvate production precedes G3P. In terms of precursor generation and energy/reducing-equivalent supply, EDP+PPP was found to be the ideal feeding module for MEP. These findings may launch a new direction for the optimization of MEP-dependent isoprenoid biosynthesis pathways. PMID:24376679

European Cooperation in Development Information and Documentation. Report of the International Conference (Berlin, October 9-14, 1983).

ERIC Educational Resources Information Center

German Foundation for International Development, Bonn (West Germany).

This conference, which was attended by librarians and documentalists from 12 European countries (East and West) and, for the first time, some Third World countries, emphasized the role of electronic data processing (EDP) in information and documentation, particularly in terms of one possible means by which to overcome the barriers in international…

Nanoscale structure of the oil-water interface

DOE PAGES

Fukuto, M.; Ocko, B. M.; Bonthuis, D. J.; ...

2016-12-15

X-ray reflectivity (XR) and atomistic molecular dynamics (MD) simulations, carried out to determine the structure of the oil-water interface, provide new insight into the simplest liquid-liquid interface. For several oils (hexane, dodecane, and hexadecane) the XR shows very good agreement with a monotonic interface-normal electron density profile (EDP) broadened only by capillary waves. Similar agreement is also found for an EDP including a sub-Å thick electron depletion layer separating the oil and the water. As a result, the XR and MD derived depletions are much smaller than reported for the interface between solid-supported hydrophobic monolayers and water.

Astrocyte and Neuronal Plasticity in the Somatosensory System

PubMed Central

Sims, Robert E.; Butcher, John B.; Parri, H. Rheinallt; Glazewski, Stanislaw

2015-01-01

Changing the whisker complement on a rodent's snout can lead to two forms of experience-dependent plasticity (EDP) in the neurons of the barrel cortex, where whiskers are somatotopically represented. One form, termed coding plasticity, concerns changes in synaptic transmission and connectivity between neurons. This is thought to underlie learning and memory processes and so adaptation to a changing environment. The second, called homeostatic plasticity, serves to maintain a restricted dynamic range of neuronal activity thus preventing its saturation or total downregulation. Current explanatory models of cortical EDP are almost exclusively neurocentric. However, in recent years, increasing evidence has emerged on the role of astrocytes in brain function, including plasticity. Indeed, astrocytes appear as necessary partners of neurons at the core of the mechanisms of coding and homeostatic plasticity recorded in neurons. In addition to neuronal plasticity, several different forms of astrocytic plasticity have recently been discovered. They extend from changes in receptor expression and dynamic changes in morphology to alteration in gliotransmitter release. It is however unclear how astrocytic plasticity contributes to the neuronal EDP. Here, we review the known and possible roles for astrocytes in the barrel cortex, including its plasticity. PMID:26345481

Required number of records for ASCE/SEI 7 ground-motion scaling procedure

USGS Publications Warehouse

Reyes, Juan C.; Kalkan, Erol

2011-01-01

The procedures and criteria in 2006 IBC (International Council of Building Officials, 2006) and 2007 CBC (International Council of Building Officials, 2007) for the selection and scaling ground-motions for use in nonlinear response history analysis (RHA) of structures are based on ASCE/SEI 7 provisions (ASCE, 2005, 2010). According to ASCE/SEI 7, earthquake records should be selected from events of magnitudes, fault distance, and source mechanisms that comply with the maximum considered earthquake, and then scaled so that the average value of the 5-percent-damped response spectra for the set of scaled records is not less than the design response spectrum over the period range from 0.2Tn to 1.5Tn sec (where Tn is the fundamental vibration period of the structure). If at least seven ground-motions are analyzed, the design values of engineering demand parameters (EDPs) are taken as the average of the EDPs determined from the analyses. If fewer than seven ground-motions are analyzed, the design values of EDPs are taken as the maximum values of the EDPs. ASCE/SEI 7 requires a minimum of three ground-motions. These limits on the number of records in the ASCE/SEI 7 procedure are based on engineering experience, rather than on a comprehensive evaluation. This study statistically examines the required number of records for the ASCE/SEI 7 procedure, such that the scaled records provide accurate, efficient, and consistent estimates of" true" structural responses. Based on elastic-perfectly-plastic and bilinear single-degree-of-freedom systems, the ASCE/SEI 7 scaling procedure is applied to 480 sets of ground-motions. The number of records in these sets varies from three to ten. The records in each set were selected either (i) randomly, (ii) considering their spectral shapes, or (iii) considering their spectral shapes and design spectral-acceleration value, A(Tn). As compared to benchmark (that is, "true") responses from unscaled records using a larger catalog of ground-motions, it is demonstrated that the ASCE/SEI 7 scaling procedure is overly conservative if fewer than seven ground-motions are employed. Utilizing seven or more randomly selected records provides a more accurate estimate of the EDPs accompanied by reduced record-to-record variability of the responses. Consistency in accuracy and efficiency is achieved only if records are selected on the basis of their spectral shape and A(Tn).

[3D imaging benefits in clinical pratice of orthodontics].

PubMed

Frèrejouand, Emmanuel

2016-12-01

3D imaging possibilities raised up in the last few years in the orthodontic field. In 2016, it can be used for diagnosis improvement and treatment planning by using digital set up combined to CBCT. It is relevant for orthodontic mechanic updating by creating visible or invisible customised appliances. It forms the basis of numerous scientific researches. The author explains the progress 3D imaging brings to diagnosis and clinics but also highlights the requirements it creates. The daily use of these processes in orthodontic clinical practices needs to be regulated regarding the benefit/risk ratio and the patient satisfaction. The command of the digital work flow created by these technics requires habits modifications from the orthodontist and his staff. © EDP Sciences, SFODF, 2016.

Managing Computer Systems Development: Understanding the Human and Technological Imperatives.

DTIC Science & Technology

1985-06-01

for their organization’s use? How can they predict tle impact of future systems ca their management control capabilities ? Cf equal importance is the...commercial organizations discovered that there was only a limited capability of interaction between various types of computers. These organizations were...Viewed together, these three interrelated subsystems, EDP, MIS, and DSS, establish the framework of an overall systems capability known as a Computer

ONR K-16 Engineering Pipeline: Engineering Success in STEM Project

DTIC Science & Technology

2016-10-19

contributed to fewer items being rated as significantly higher on the post - test . Most of these items were designed to assess confidence with specific...the second group talked about the application of the EDP in many different content areas. One stated , "What I like about the engineering design ... designating a point person at each school and providing some direction for unit development to get groups started. One example was the suggestion to

Information Interface Related Standards, Guidelines, and Recommended Practices.

DTIC Science & Technology

1985-07-01

Application Workshop, IEEE, October 1984 (11) Software Portability and Standards, by Ingemar Dahlstrand, Ellis Horwood Ltd., 1984 (12) World of EDP...March 29, 1985, p. 42-48 * 9. "IBM’s Topview Plays to Poor Reviews of Early Users," Computer World , March 4, 1985, p. 5 10. "Lack of Software Standards...Information Symbols ISOiTR 7239-1984 - Development and Principles for Application of Public Information Symbols ISO/TR 8545 -1984 - Technical Drawings

Discrepancy between social and nonsocial decision-making under uncertainty following prefrontal lobe damage: the impact of an interactionist approach.

PubMed

Besnard, J; Le Gall, D; Chauviré, V; Aubin, G; Etcharry-Bouyx, F; Allain, P

2017-08-01

Deficits in decision-making are thought to contribute significantly to socio-behavioral impairments of patients with frontal lobe damage. The purpose of this study was to test the hypothesis of whether the inappropriate social behavior of patients with frontal lesions can be viewed as the product of a general failure of decision-making ability or as the result of socio-cognitive impairment. We studied a group of patients with prefrontal lesions (FL patients, n = 15) and a group of matched healthy controls (n = 30) on the Iowa Gambling task (IGT) of nonsocial decision-making, environmental dependency phenomena (EDP) during social interaction, and the "reading the mind in the eyes" and "character intention task" of theory of mind (TOM) tasks. The FL patients were impaired in both TOM and EDP protocols but, surprisingly, they behaved appropriately in the IGT. In addition, FL patients with EDP did not differ in executive functioning, IGT and TOM measures from those who did not demonstrate these behavioral disorders. The right orbitofrontal cortex was associated with social decision-making deficits. By adopting an interactionist approach, this study raises the possibility of identifying components of social and nonsocial decision-making, which could be helpful in understanding the behavioral disorders of FL patients.

Performance analysis and kernel size study of the Lynx real-time operating system

NASA Technical Reports Server (NTRS)

Liu, Yuan-Kwei; Gibson, James S.; Fernquist, Alan R.

1993-01-01

This paper analyzes the Lynx real-time operating system (LynxOS), which has been selected as the operating system for the Space Station Freedom Data Management System (DMS). The features of LynxOS are compared to other Unix-based operating system (OS). The tools for measuring the performance of LynxOS, which include a high-speed digital timer/counter board, a device driver program, and an application program, are analyzed. The timings for interrupt response, process creation and deletion, threads, semaphores, shared memory, and signals are measured. The memory size of the DMS Embedded Data Processor (EDP) is limited. Besides, virtual memory is not suitable for real-time applications because page swap timing may not be deterministic. Therefore, the DMS software, including LynxOS, has to fit in the main memory of an EDP. To reduce the LynxOS kernel size, the following steps are taken: analyzing the factors that influence the kernel size; identifying the modules of LynxOS that may not be needed in an EDP; adjusting the system parameters of LynxOS; reconfiguring the device drivers used in the LynxOS; and analyzing the symbol table. The reductions in kernel disk size, kernel memory size and total kernel size reduction from each step mentioned above are listed and analyzed.

A prospective, randomised trial of different matching procedures for structured mentoring programmes in medical education.

PubMed

Schäfer, Matthias; Pander, Tanja; Pinilla, Severin; Fischer, Martin R; von der Borch, Philip; Dimitriadis, Konstantinos

2016-09-01

Spontaneous formation of mentoring relationships can be seen as the gold standard in mentoring. Unfortunately, it happens very infrequently. The purpose of structured mentoring programmes is to facilitate the formation of mentoring relationships. This remains a challenging task, especially for large institutions. We set out to investigate and compare three methods of matchmaking in the setting of our structured mentoring programme. In a prospective, randomised trial we compared personal matching (PM) by an experienced expert to two different electronic data processing (EDP)-supported matching procedures: "online algorithm" (OA) versus "online search" (OS). PM was performed after structured interviews of prospective protégés by one founder of our mentoring programme. The OA provides students with a choice of 10 potential mentors based on comparison of online profiles. OS lets students filter and search through all available mentor profiles. One hundred and ninty medical students were randomised into the three groups. One year later, we evaluated the endpoints 1. "establishment of a mentoring relationship" and 2. "satisfaction with the mentoring relationship". Satisfaction with the mentoring relationship was assessed using Munich-Evaluation-of-Mentoring-Questionnaire (MEMeQ). One hundred sixty-five out of the 190 study participants found a mentor. With regards to endpoint one we found an advantage of PM compared to both EDP-supported matching procedures. There was no significant difference between OA and OS. Concerning endpoint two the differences between the investigated matching procedures were not significant. PM is superior as to the number of mentoring relationships formed per participating student compared to EDP-supported methods. In our data, there was no significant difference in the level of satisfaction. Considering the high investments associated with PM of mentors and protégés, EDP-supported matching procedures seem a viable compromise between effectiveness and efficiency especially for large-scale structured mentoring programmes in medical education.

Effect of weak measurement on entanglement distribution over noisy channels.

PubMed

Wang, Xin-Wen; Yu, Sixia; Zhang, Deng-Yu; Oh, C H

2016-03-03

Being able to implement effective entanglement distribution in noisy environments is a key step towards practical quantum communication, and long-term efforts have been made on the development of it. Recently, it has been found that the null-result weak measurement (NRWM) can be used to enhance probabilistically the entanglement of a single copy of amplitude-damped entangled state. This paper investigates remote distributions of bipartite and multipartite entangled states in the amplitudedamping environment by combining NRWMs and entanglement distillation protocols (EDPs). We show that the NRWM has no positive effect on the distribution of bipartite maximally entangled states and multipartite Greenberger-Horne-Zeilinger states, although it is able to increase the amount of entanglement of each source state (noisy entangled state) of EDPs with a certain probability. However, we find that the NRWM would contribute to remote distributions of multipartite W states. We demonstrate that the NRWM can not only reduce the fidelity thresholds for distillability of decohered W states, but also raise the distillation efficiencies of W states. Our results suggest a new idea for quantifying the ability of a local filtering operation in protecting entanglement from decoherence.

Effect of weak measurement on entanglement distribution over noisy channels

PubMed Central

Wang, Xin-Wen; Yu, Sixia; Zhang, Deng-Yu; Oh, C. H.

2016-01-01

Being able to implement effective entanglement distribution in noisy environments is a key step towards practical quantum communication, and long-term efforts have been made on the development of it. Recently, it has been found that the null-result weak measurement (NRWM) can be used to enhance probabilistically the entanglement of a single copy of amplitude-damped entangled state. This paper investigates remote distributions of bipartite and multipartite entangled states in the amplitudedamping environment by combining NRWMs and entanglement distillation protocols (EDPs). We show that the NRWM has no positive effect on the distribution of bipartite maximally entangled states and multipartite Greenberger-Horne-Zeilinger states, although it is able to increase the amount of entanglement of each source state (noisy entangled state) of EDPs with a certain probability. However, we find that the NRWM would contribute to remote distributions of multipartite W states. We demonstrate that the NRWM can not only reduce the fidelity thresholds for distillability of decohered W states, but also raise the distillation efficiencies of W states. Our results suggest a new idea for quantifying the ability of a local filtering operation in protecting entanglement from decoherence. PMID:26935775

Evaluation of fault-normal/fault-parallel directions rotated ground motions for response history analysis of an instrumented six-story building

USGS Publications Warehouse

Kalkan, Erol; Kwong, Neal S.

2012-01-01

According to regulatory building codes in United States (for example, 2010 California Building Code), at least two horizontal ground-motion components are required for three-dimensional (3D) response history analysis (RHA) of buildings. For sites within 5 km of an active fault, these records should be rotated to fault-normal/fault-parallel (FN/FP) directions, and two RHA analyses should be performed separately (when FN and then FP are aligned with the transverse direction of the structural axes). It is assumed that this approach will lead to two sets of responses that envelope the range of possible responses over all nonredundant rotation angles. This assumption is examined here using a 3D computer model of a six-story reinforced-concrete instrumented building subjected to an ensemble of bidirectional near-fault ground motions. Peak responses of engineering demand parameters (EDPs) were obtained for rotation angles ranging from 0° through 180° for evaluating the FN/FP directions. It is demonstrated that rotating ground motions to FN/FP directions (1) does not always lead to the maximum responses over all angles, (2) does not always envelope the range of possible responses, and (3) does not provide maximum responses for all EDPs simultaneously even if it provides a maximum response for a specific EDP.

Decompression Sickness and U-2 Operations: Summary of Research, Findings, and Recommendations Regarding Use of Exercise During Prebreathe

DTIC Science & Technology

2010-03-01

Research Laboratory Hypobaric DCS Research Database developed at Brooks AFB, TX, which has detailed information on over 3,000 research chamber... hyperbaric oxygen therapy resulting in complete resolution of all symptoms. After instituting EDP, the same pilot flew 36 U-2 high flights without any...consultation with base SGP and USAFSAM Hyperbarics and MAJCOM/SGPA. Earlier guidance in the 1980’s was much more restrictive and, in fact, permanently

Electro-deposition painting process improvement of cab truck by Six Sigma concept

NASA Astrophysics Data System (ADS)

Kawitu, Kitiya; Chutima, Parames

2017-06-01

The case study company is a manufacturer of trucks and currently facing a high rework cost due to the thickness of the electro-deposited paint (EDP) of the truck cab is lower than standard. In addition, the process capability is very low. The Six Sigma concept consisting of 5 phases (DMAIC) is applied to determine new parameter settings for each significant controllable factor. After the improvement, EDP thickness of the truck cab increases from 17.88μ to 20μ (i.e. standard = 20 ± 3μ). Moreover, the process capability indexes (Cp and Cpk) are increased from 0.9 to 1.43, and from 0.27 to 1.43, respectively. This improvement could save the rework cost about 1.6M THB per year.

Physiological control of dual rotary pumps as a biventricular assist device using a master/slave approach.

PubMed

Stevens, Michael C; Wilson, Stephen; Bradley, Andrew; Fraser, John; Timms, Daniel

2014-09-01

Dual rotary left ventricular assist devices (LVADs) can provide biventricular mechanical support during heart failure. Coordination of left and right pump speeds is critical not only to avoid ventricular suction and to match cardiac output with demand, but also to ensure balanced systemic and pulmonary circulatory volumes. Physiological control systems for dual LVADs must meet these objectives across a variety of clinical scenarios by automatically adjusting left and right pump speeds to avoid catastrophic physiological consequences. In this study we evaluate a novel master/slave physiological control system for dual LVADs. The master controller is a Starling-like controller, which sets flow rate as a function of end-diastolic ventricular pressure (EDP). The slave controller then maintains a linear relationship between right and left EDPs. Both left/right and right/left master/slave combinations were evaluated by subjecting them to four clinical scenarios (rest, postural change, Valsalva maneuver, and exercise) simulated in a mock circulation loop. The controller's performance was compared to constant-rotational-speed control and two other dual LVAD control systems: dual constant inlet pressure and dual Frank-Starling control. The results showed that the master/slave physiological control system produced fewer suction events than constant-speed control (6 vs. 62 over a 7-min period). Left/right master/slave control had lower risk of pulmonary congestion than the other control systems, as indicated by lower maximum EDPs (15.1 vs. 25.2-28.4 mm Hg). During exercise, master/slave control increased total flow from 5.2 to 10.1 L/min, primarily due to an increase of left and right pump speed. Use of the left pump as the master resulted in fewer suction events and lower EDPs than when the right pump was master. Based on these results, master/slave control using the left pump as the master automatically adjusts pump speed to avoid suction and increases pump flow during exercise without causing pulmonary venous congestion. Copyright © 2014 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Erosion Prediction Analysis and Landuse Planning in Gunggung Watershed, Bali, Indonesia

NASA Astrophysics Data System (ADS)

Trigunasih, N. M.; Kusmawati, T.; Yuli Lestari, N. W.

2018-02-01

The purpose of this research is to predict the erosion that occurs in Gunggung watershed and sustainable landuse management plan. This research used the USLE (Universal Soil Loss Equation) methodology. The method used observation / field survey and soil analysis at the Soil Laboratory of Faculty of Agriculture, Udayana University. This research is divided into 5 stages, (1) land unit determination, (2) Field observation and soil sampling, (3) Laboratory analysis and data collection, (4) Prediction of erosion using USLE (Universal Soil Loss Equation) method, (5) The permissible erosion determination (EDP) then (6) determines the level of erosion hazard based on the depth of the soil, as well as the soil conservation plan if the erosion is greater than the allowed erosion, and (7) determining landuse management plan for sustainable agriculture. Erosion which value is smaller than soil loss tolerance can be exploited in a sustainable manner, while erosion exceeds allowable erosion will be conservation measures. Conservation action is the improvement of vegetation and land management. Land management like improvements the terrace, addition of organic matter, increase plant density, planting ground cover and planting layered header system will increase the land capability classes. Land use recommended after management is mixed plantation high density with forest plants, mix plantation high density with patio bench construction, seasonal cultivation and perennial crops, cultivation of perennial crops and cultivation of seasonal crops.

[Orthodontic and orthognathic protocoles: systematization of the consultation of announcement and contribution of integrative medicine].

PubMed

Racy, Emmanuel; Le Norcy, Elvire

2017-12-01

The consultation of announcement is one of the key periods in an orthodontic and surgical process. The aim of this consultation is not only to make an aesthetic and orthodontic diagnosis but also a fine psychological analysis of the patient and his family before proposing a treatment plan. Integrative medical therapies, a recent evolution of medicine within the framework of the doctor-patient relation, have shown the positive impact on the treatment success of a good relationship. The preliminary collection of information on the patient's psyches is now part of the treatment guidelines and has a positive impact on treatment observance, management of pre- and post-operative care or more simply surgery acceptance. Therefore, a systematized patient record process including global medical assessment of the patient and not only orthodontic and cephalometric diagnosis is a key factor for the treatment outcome. © EDP Sciences, SFODF, 2017.

Environmental audit: III. Improving the management of environmental information for toxic substances

NASA Astrophysics Data System (ADS)

Sokolik, Stanley L.; Schaeffer, David J.

1986-05-01

Environmental programs have been commonly driven by a preoccupation with the collection of data in the mistaken belief that data is synonymous with information. The distinction between data (that is, the quantified and qualitative attributes of a particular environment) and information (specifically, data processed so as to focus upon a particular environmental problem) will become far more important to environmental managers. They will increasingly manage their information through use of what has become known as information resource management (IRM) and the attendant use of critical success factors methodology. Environmental managers will thereby move away from concerns about data and specific EDP hardware and applications toward managing information as a valuable agency resource. In applying IRM, they will find it helpful to include a number of planning elements and to resolve early a number of issues critical to its successful use.

Effects of dry period length and concentrate protein content in late lactation on body condition score change and subsequent lactation performance of thin high genetic merit dairy cows.

PubMed

Dale, A J; Purcell, P J; Wylie, A R G; Gordon, A W; Ferris, C P

2017-03-01

Improving body condition score of thin cows in late lactation is necessary, because cows that are thin at drying off exhibit decreased fertility postpartum and are at increased risk of disease and of being culled in the subsequent lactation. Offering a diet low in crude protein (CP) content in late lactation may help to improve body condition score (BCS) at drying off, whereas imposing an extended dry period (EDP) has been advocated as another way to increase BCS at calving. To test these hypotheses, 65 thin cows (mean BCS 2.25 at 14 wk precalving) were managed on 1 of 3 treatments between 13 and 9 wk prepartum: normal protein control {NP; grass silage + 5 kg/d of a normal protein concentrate [228 g of CP/kg of dry matter (DM)]}, low protein [LP; grass silage + 5 kg/d of a low-protein concentrate (153 g of CP/kg of DM)], or EDP (cows dried off at 13 wk precalving and offered a grass silage-only diet). Both NP and LP cows were dried off at wk 8 prepartum, after which all cows were offered a grass silage-only diet until calving. After calving, all cows were offered a common diet (supplying 11.1 kg of concentrate DM/cow per day) for 19 wk. Between 13 and 9 wk prepartum, LP cows had lower DM intake, milk yield, and body weight than NP cows. Whereas EDP cows had lower serum β-hydroxybutyrate and fatty acid concentrations than those of NP cows, BCS at wk 9 prepartum did not differ between treatments. Cows on the LP treatment continued to have lower DMI and BW than those of NP and EDP cows between 8 wk prepartum and calving, but only EDP cows had a higher BCS at calving. Treatment did not affect calving difficulty score or calf birth weight. Although all cows were offered a common diet postpartum, cows on the LP treatment had lower DM intake and milk fat + plus protein yield than cows on any other treatment during the 19-wk period postpartum, but we found no differences in any postpartum indicator of body tissue reserves. The treatments imposed from wk 13 to 9 prepartum had no effect on any fertility or health parameters examined postpartum. Extending the dry period for thin cows improved their BCS at calving but did not allow these cows to achieve the target BCS of 2.75, and we found no beneficial effects of this treatment on cow performance postpartum. Offering a lower-protein diet to thin cows in late lactation did not improve BCS at calving above that of cows on a normal protein diet, but had unexplained long-term negative effects on cow performance. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

On the feasibility of closed-loop control of intra-aortic balloon pumping

NASA Technical Reports Server (NTRS)

Clark, J. W., Jr.; Bourland, H. M.; Kane, G. R.

1973-01-01

A closed-loop control scheme for the control of intra-aortic balloon pumping has been developed and tested in dog experiments. A performance index reflecting the general objectives of balloon-assist pumping is developed and a modified steepest ascent control algorithm is utilized for the selection of a proper operating point for the balloon during its pumping cycle. This paper attempts to indicate the feasibility of closed-loop control of balloon pumping, and particularly its flexibility in achieving both diastolic augmentation of mean aortic pressure and control of the level of end-diastolic pressure (EDP) an important factor in reducing heart work.

[Orthodontics and cosmetic composite for treatment ending: ultra conservative approach of the smile restoring].

PubMed

Grossetti, François

2013-12-01

Thanks to alignment, bleaching and bonding, cosmetic dentistry is rising. The cases presented in this article are treated through minimal invasive dentistry linked to orthodontics. © EDP Sciences, SFODF, 2013.

High-efficient entanglement distillation from photon loss and decoherence.

PubMed

Wang, Tie-Jun; Wang, Chuan

2015-11-30

We illustrate an entanglement distillation protocol (EDP) for a mixed photon-ensemble which composed of four kinds of entangled states and vacuum states. Exploiting the linear optics and local entanglement resource (four-qubit entangled GHZ state), we design the nondemolition parity-checking and qubit amplifying (PCQA) setup for photonic polarization degree of freedom which are the key device of our scheme. With the PCQA setup, a high-fidelity entangled photon-pair system can be achieved against the transmission losses and the decoherence in noisy channels. And in the available purification range for our EDP, the fidelity of this ensemble can be improved to the maximal value through iterated operations. Compared to the conventional entanglement purification schemes, our scheme largely reduces the initialization requirement of the distilled mixed quantum system, and overcomes the difficulties posed by inherent channel losses during photon transmission. All these advantages make this scheme more useful in the practical applications of long-distance quantum communication.

Investigations of gain redshift in high peak power Ti:sapphire laser systems

NASA Astrophysics Data System (ADS)

Wu, Fenxiang; Yu, Linpeng; Zhang, Zongxin; Li, Wenkai; Yang, Xiaojun; Wu, Yuanfeng; Li, Shuai; Wang, Cheng; Liu, Yanqi; Lu, Xiaoming; Xu, Yi; Leng, Yuxin

2018-07-01

Gain redshift in high peak power Ti:sapphire laser systems can result in narrowband spectral output and hence lengthen the compressed pulse duration. In order to realize broadband spectral output in 10 PW-class Ti:sapphire lasers, the influence on gain redshift induced by spectral pre-shaping, gain distribution of cascaded amplifiers and Extraction During Pumping (EDP) technique have been investigated. The theoretical and experimental results show that the redshift of output spectrum is sensitive to the spectral pre-shaping and the gain distribution of cascaded amplifiers, while insensitive to the pumping scheme with or without EDP. Moreover, the output spectrum from our future 10 PW Ti:sapphire laser is theoretically analyzed based on the investigations above, which indicates that a Fourier-transform limited (FTL) pulse duration of 21 fs can be achieved just by optimizing the spectral pre-shaping and gain distribution in 10 PW-class Ti:sapphire lasers.

Thin Disk Ti:Sapphire amplifiers for Joule-class ultrashort pulses with high repetition rate (Conference Presentation)

NASA Astrophysics Data System (ADS)

Nagymihály, Roland S.; Cao, Huabao; Kalashnikov, Mikhail P.; Khodakovskiy, Nikita; Ehrentraut, Lutz; Osvay, Károly; Chvykov, Vladimir V.

2017-05-01

High peak power CPA laser systems can deliver now few petawatt pulses [1]. Reaching the high energies with broad spectral bandwidth necessary for these pulses was possible by the use of large aperture Ti:Sa crystals as final amplifier media. Wide applications for these systems will be possible if the repetition rate could be increased. Therefore, thermal deposition in Ti:Sa amplifiers is a key issue, which has to be solved in case of high average power pumping. The thin disk (TD) laser technology, which is intensively developed nowadays by using new laser materials, is able to overcome thermal distortions and damages of laser crystals [2]. TD technique also has the potential to be used in systems with both high peak and average power. For this, the commonly used laser materials with low absorption and emission cross sections, also low heat conductivity, like Yb:YAG, need to be replaced by a gain medium that supports broad enough emission spectrum and high thermal conductivity to obtain few tens of fs pulses with high repetition rates. Parasitic effects during the amplification process however seriously limit the energy that can be extracted from the gain medium and also they distort the gain profile. Nevertheless, the application of the Extraction During Pumping (EDP) technique can mitigate the depopulation losses in the gain medium with high aspect ratio [3]. We proposed to use Ti:Sa in combination with TD and EDP techniques to reach high energies at high repetition rates, and we presented numerical simulations for different amplifier geometries and parameters of the amplification [4,5]. We present the results of the proof-of-principle experiment, where a EDP-TD Ti:Sa amplifier was tested for the first time. In our experiment, the final cryogenically cooled Ti:Sa amplifier in a 100 TW/10 Hz/28 fs laser system was replaced with the EDP-TD room temperature cooled arrangement. Amplified seed pulse energy of 2.6 J was reached only for 3 passes through TD with 0.5 J of input seed and 5 J of absorbed pump energy. We verified the excellent heat extraction capabilities of our amplifier module. Results of the scaling simulations on the base of this experiment for 100s of TW peak power laser systems operating at up to 100 Hz will be also presented. References 1. Y. Chu et al, Opt. Lett. 40, 5011-5014 (2015). 2. C. R. E. Baer et al, Opt. Exp. 20, 7054-7065 (2012). 3. V. Chvykov et al, Opt. Comm. 285, 2134-2136 (2012). 4. V. Chvykov, R. S. Nagymihaly, H. Cao, M. Kalashnikov, K. Osvay, Opt. Exp. 24, 3721 (2016). 5. V.Chvykov, R. S. Nagymihaly, H. Cao, M. Kalashnikov, K. Osvay, Opt. Lett. 41,13, 3017 (2016).

The EDP-5E

ERIC Educational Resources Information Center

Lottero-Perdue, Pamela; Bolotin, Sonja; Benyameen, Ruth; Brock, Erin; Metzger, Ellen

2015-01-01

Many preservice and practicing elementary teachers are familiar with the 5E learning cycle. This cycle provides a relatively simple, alliteratively memorable framework for teaching science in which lessons (or even entire units of instruction) consist of five distinct phases: Engagement, Exploration, Explanation, Elaboration/Extension (hereafter,…

Speckle-Tracking Echocardiography Improves Pre-operative Risk Stratification Before the Total Cavopulmonary Connection.

PubMed

Park, Patsy W; Atz, Andrew M; Taylor, Carolyn L; Chowdhury, Shahryar M

2017-05-01

Single-ventricle patients with elevated pulmonary vascular resistance (PVR) or end-diastolic pressure (EDP) are excluded from undergoing total cavopulmonary connection (TCPC). However, a subset of patients deemed to be at acceptable risk experience prolonged length of stay (LOS) after TCPC. Routine assessment of ventricular function has been inadequate in identifying these high-risk patients. Speckle-tracking echocardiography (STE) is a novel method for assessment of myocardial deformation that may be useful in single-ventricle patients. The aim of this study was to perform a contemporary preoperative risk assessment for prolonged LOS to determine whether STE improves risk stratification before TCPC. Our single institution's perioperative data were retrospectively collected. The primary outcome was postoperative LOS >14 days. Longitudinal and circumferential STE deformation measures were analyzed on echocardiograms obtained during preoperative catheterization. Patient-specific, echocardiographic, and catheterization data were included in multivariable logistic regression. Receiver operating characteristic area under the curves (AUC) were analyzed. From 2007 to 2014, 135 patients who underwent TCPC were included in the analysis. The median LOS was 11 (IQR 9-14) days. The PVR (P < .01) and circumferential strain rate (CSR) (P < .01) were the only variables independently associated with LOS >14 days. For every 0.1 s -1 CSR increased, there was a 20% increased odds of prolonged LOS. The AUC for CSR was 0.70. The AUC for PVR and EDP combined was 0.68. The AUC for PVR, EDP, and CSR combined was 0.73. Preoperative CSR is independently associated with LOS >14 days and improves preoperative risk stratification in patients undergoing TCPC. Copyright © 2017 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.

Design study on the efficiency of the thermal scheme of power unit of thermal power plants in hot climates

NASA Astrophysics Data System (ADS)

Sedlov, A.; Dorokhov, Y.; Rybakov, B.; Nenashev, A.

2017-11-01

At the stage of pre-proposals unit of the thermal power plants for regions with a hot climate requires a design study on the efficiency of possible options for the structure of the thermal circuit and a set of key parameters. In this paper, the thermal circuit of the condensing unit powerfully 350 MW. The main feature of the external conditions of thermal power plants in hot climates is the elevated temperature of cooling water of the turbine condensers. For example, in the Persian Gulf region as the cooling water is sea water. In the hot season of the year weighted average sea water temperature of 30.9 °C and during the cold season to 22.8 °C. From the turbine part of the steam is supplied to the distillation-desalination plant. In the hot season of the year heat scheme with pressure fresh pair of 23.54 MPa, temperature 570/560 °C and feed pump with electric drive (EDP) is characterized by a efficiency net of 0.25% higher than thermal schem with feed turbine pump (TDP). However, the supplied power unit with PED is less by 11.6 MW. Calculations of thermal schemes in all seasons of the year allowed us to determine the difference in the profit margin of units of the TDP and EDP. During the year the unit with the TDP provides the ability to obtain the profit margin by 1.55 million dollars more than the unit EDP. When using on the market subsidized price of electricity (Iran) marginal profit of a unit with TDP more at 7.25 million dollars.

[Beauty and esthetics: juridical approach].

PubMed

Béry, Alain; Delprat, Laurent

2014-03-01

Although beauty is increasingly becoming a right mostly as it relates to objects, people are now beginning to make a new demand - the right to personal beauty: the right to live in and surrounded by beauty and the right to be beautiful. © EDP Sciences, SFODF, 2014.

Understanding how police officers think about mental/emotional disturbance calls

PubMed Central

Watson, Amy C; Swartz, James; Bohrman, Casey; Kriegel, Liat S.; Draine, Jeffrey

2014-01-01

Police officers frequently respond to calls involving persons with mental illnesses and in doing so, they are key gatekeepers of access to mental health treatment as well as entry into the criminal justice system. Programs such as Crisis Intervention Teams (CIT) are being implemented across the United States and elsewhere to train officers to respond more effectively and facilitate access to mental health services when appropriate. These programs would benefit from a thorough understanding of these encounters from the perspective of police officers. We take as a premise that officers develop frames of reference or “schema” for understanding and responding to these encounters that are shaped by socialization, training, and their experience as police officers. In this study, we examine police officer schema of mental/emotional disturbance (M/EDP) calls. Qualitative interviews provided the foundation to develop the Needs on the Street Interview (NOSI) to tap officer schema of four types of M/EDP scenarios. The NOSI was administered to 147 officers in Chicago and Philadelphia. Latent Class Analysis (LCA) was conducted separately for each scenario to examine groups of officers with different schema as well as predictors of schema group. For three of the four scenarios, officers were classified into a two category or schema model, for the fourth (crime reported) a three category model was supported. Schema groups tended to be differentiated by ratings of level of resistance/threat and substance use. Contrary to our expectations, CIT and law enforcement experience did not predict officer schema group. While the CIT model emphasizes de-escalation skills to reduce resistance and the need for officers to use force, CIT and other training programs may want to consider increasing content related to factors such as co-occurring substance use and managing resistance. PMID:24656216

[Scientific role of German ophthalmology in the European telecommunication project OPHTEL].

PubMed

Mertz, M; Mann, G; Zahlmann, G; Obermaier, M

1997-07-01

In Denmark, France, Germany, Great Britain and Italy, the OPHTEL project combines clinical centers of ophthalmology and internal medicine, an institute for medical informatics and health services research, a publishing company and different industrial partners in the EDP market. With the aid of visual telecommunication and rapid data transfer, methods and conditions will be developed and proved so that any physician can very easily obtain sufficient information for treating his patient. Thus, the regional differences in the quality of structured health service (e.g., urban/ rural) will be overcome throughout Europe. SCIENTIFIC TASKS: A multilingual diagnostic and therapeutic thesaurus has to be worked out in order to create standards for communication and quality control. Based on literature, images and image analysis in a knowledge-based data bank, a monitoring system (containing watch-dog functions) and the basic aspects of an ophthalmological patient/disease register will be investigated. (In parallel, a technical development of synchronous and asynchronous telecommunication between eye physicians is taking place in close cooperation with the regional Bavarian project Teleopathalmology in Bavaria on-line). State of the art 6 months after starting the project:the knowledge-based image data bank has been founded and also an ophthalmological 8 language thesaurus and definition standard. All data transfer lines are installed. The project is taking place amid diverging sections of medicine: ophthalmology and internal medicine, health politics and data protection, individual treatment and common interest (health care), product management and office organization. Thus, the scientific quality of the transferred ophthalmological content must undergo sophisticated controls. FUTURE STEPS: Intense cooperation with the big German associations for ophthalmology (DOG, BVA) and the European ophthalmological societies concerning EDP, classification and quality control.

A novel essential domain perspective for exploring gene essentiality.

PubMed

Lu, Yao; Lu, Yulan; Deng, Jingyuan; Peng, Hai; Lu, Hui; Lu, Long Jason

2015-09-15

Genes with indispensable functions are identified as essential; however, the traditional gene-level studies of essentiality have several limitations. In this study, we characterized gene essentiality from a new perspective of protein domains, the independent structural or functional units of a polypeptide chain. To identify such essential domains, we have developed an Expectation-Maximization (EM) algorithm-based Essential Domain Prediction (EDP) Model. With simulated datasets, the model provided convergent results given different initial values and offered accurate predictions even with noise. We then applied the EDP model to six microbial species and predicted 1879 domains to be essential in at least one species, ranging 10-23% in each species. The predicted essential domains were more conserved than either non-essential domains or essential genes. Comparing essential domains in prokaryotes and eukaryotes revealed an evolutionary distance consistent with that inferred from ribosomal RNA. When utilizing these essential domains to reproduce the annotation of essential genes, we received accurate results that suggest protein domains are more basic units for the essentiality of genes. Furthermore, we presented several examples to illustrate how the combination of essential and non-essential domains can lead to genes with divergent essentiality. In summary, we have described the first systematic analysis on gene essentiality on the level of domains. huilu.bioinfo@gmail.com or Long.Lu@cchmc.org Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

[Perfecting smile esthetics: keep it pink!

PubMed

Monnet-Corti, Virginie; Antezack, Angeline; Pignoly, Marion

2018-03-01

Smile aesthetics is based on numerical, physical, physiological and psychological data regarding beauty, while taking into account the desires of the patient. It is determined by the shape, colour and position of the lips, teeth and gingival tissues. Periodontal examination in both the facial and labial settings supports analysis of the gingival display during natural and forced smiling, the health of the periodontium, the gingival contours, the aesthetic gingival line, and the presence of the papillae. All these data will help establish a gingival aesthetic score to determine the causes of disharmony and possible treatment. During implementation of the global orthodontic treatment plan, periodontal plastic surgery can change the gingival appearance and morphology in order to restore the harmony of the smile. Subtractive periodontal plastic surgery treats biological space defects and excess tissue during incomplete passive eruption by gingivectomy or apically positioned flap, combined, or not, with osteoplasty or osteoectomy. Finally, injections of hyaluronic acid in the papillae can plump them up and minimize the size of any black holes. © EDP Sciences, SFODF, 2018.

Putting 3D modelling and 3D printing into practice: virtual surgery and preoperative planning to reconstruct complex post-traumatic skeletal deformities and defects.

PubMed

Tetsworth, Kevin; Block, Steve; Glatt, Vaida

2017-01-01

3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application, patient-specific 3D printed titanium truss cages represent a novel approach for managing the challenge of segmental bone defects. This review illustrates the potential indications of this innovative technique using 3D printed titanium truss cages in conjunction with the Masquelet technique. These implants are custom designed during a virtual surgical planning session with the combined input of an orthopaedic surgeon, an orthopaedic engineering professional and a biomedical design engineer. The ability to 3D model an identical replica of the original intact bone in a virtual procedure is of vital importance when attempting to precisely reconstruct normal anatomy during the actual procedure. Additionally, other important factors must be considered during the planning procedure, such as the three-dimensional configuration of the implant. Meticulous design is necessary to allow for successful implantation through the planned surgical exposure, while being aware of the constraints imposed by local anatomy and prior implants. This review will attempt to synthesize the current state of the art as well as discuss our personal experience using this promising technique. It will address implant design considerations including the mechanical, anatomical and functional aspects unique to each case. © The Authors, published by EDP Sciences, 2017.

77 FR 38587 - Marine Mammals; File No. 14325

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... appointment in the following offices: Permits and Conservation Division, Office of Protected Resources, NMFS... restraint of pups in the eastern Distinct Population Segment (eDPS) and western DPS (wDPS); capture of adult... have a significant adverse impact on the human environment. As required by the ESA, issuance of this...

Teaching Engineering Design Through Paper Rockets

ERIC Educational Resources Information Center

Welling, Jonathan; Wright, Geoffrey A.

2018-01-01

The paper rocket activity described in this article effectively teaches the engineering design process (EDP) by engaging students in a problem-based learning activity that encourages iterative design. For example, the first rockets the students build typically only fly between 30 and 100 feet. As students test and evaluate their rocket designs,…

Blueberry and EpidiferphaneTM (EDP) enhance calcium buffering in rat hippocampal cells and reduce stress signalling in microglial cells

USDA-ARS?s Scientific Manuscript database

Age-related decrements are thought to result from increased susceptibility to and accumulating effects of oxidative stress and inflammation. Some foods and food compounds contain bioactive phytochemicals that exhibit potent antioxidant and anti-inflammatory activities, and these foods have been show...

[The prehistory of orthodontics].

PubMed

Philippe, Julien

2015-06-01

Orthodontics came into being in 1728. Previously, practitioners were at a loss when confronted with crooked teeth. A Latin philosopher had an ingenious flash of orthodontic inspiration. Other authors were content to either extract the malposed teeth or to modify their shape. However, interest in an approach to preventive orthodontics had now begun. © EDP Sciences, SFODF, 2015.

Ethylidene-bridged Flavan-3-ols in red wine and correlation with wine age.

PubMed

Drinkine, Jessica; Lopes, Paulo; Kennedy, James A; Teissedre, Pierre-Louis; Saucier, Cedric

2007-07-25

Condensed tannins are responsible for astringency and bitterness and participate in the color stability of red wines. During wine making and aging, they undergo chemical changes including, for example, acetaldehyde-induced polymerization. Following this study, the ethylidene-bridged flavan-3-ols were monitored in different vintage wines made from grapes collected in the same vineyard in three wineries in Bordeaux, Pauillac, and Saint Julien. Flavan-3-ol ethylidene bridges were quantified by wine 2,2'-ethylidenediphloroglucinol (EDP) phloroglucinolysis. This method was based upon the analysis of EDP, a product formed after acid-catalyzed cleavage of wine flavan-3-ols in the presence of excess phloroglucinol. The flavan-3-ol ethylidene bridges were then compared to flavan-3-ol contents (phloroglucinolysis), phenolic contents, and color measurements. Low amounts of flavan-3-ol ethylidene bridges (0.8-2.5 mg L(-1)) were quantified in wines. Flavan-3-ol ethylidene bridges represent less than 4% of flavan-3-ol bonds, but the proportion of these linkages relative to native interflavan bonds increased with wine age. This proportion correlated with pigmented polymers.

Matrix ageing and vascular impacts: focus on elastin fragmentation.

PubMed

Duca, Laurent; Blaise, Sébastien; Romier, Béatrice; Laffargue, Muriel; Gayral, Stéphanie; El Btaouri, Hassan; Kawecki, Charlotte; Guillot, Alexandre; Martiny, Laurent; Debelle, Laurent; Maurice, Pascal

2016-06-01

Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

[Activity of the hypophyseal-thyroid gland system in relation to the funcitonal state of the sex glands. Report I].

PubMed

Babichev, V N; Samsonova, V M

1975-01-01

Experiments were conducted on intact female rats; it was revealed that the content of protein-bound iodine (PBI) in the blood depended on the stage of the estral cycle. It was decreased at the metestrus and diestrus stages. Castration produced an even greater reduction in the blood PBI content. The blood PBI content proved to elevate in administration of estradiol dipropionate (EDP) to castrated rats. The TSH content in the hypophysis increased at the metestrus and diestrus stages and decreased at the proestrus and estrus stages. The relationship was reverse in the case with the blood TTH content. Castration was followed by a marked increase in the TSH content in the hypophysis accompanied by a reduction in the blood hormone level. The TSH concentration in the hypophysis decreased and in the blood increased under the effect of EDP in castrated animals. The data obtained indicated that the interrelationship between the thyroid gland and the sex glands was realized at the level of the hypophysis, and possibly, of the hypothalamus.

Accounting for the environment.

PubMed

Lutz, E; Munasinghe, M

1991-03-01

Environmental awareness in the 1980s has led to efforts to improve the current UN System of National Accounts (SNA) for better measurement of the value of environmental resources when estimating income. National governments, the UN, the International Monetary Fund, and the World Bank are interested in solving this issue. The World Bank relies heavily on national aggregates in income accounts compiled by means of the SNA that was published in 1968 and stressed gross domestic product (GDP). GDP measures mainly market activity, but it takes does not consider the consumption of natural capital, and indirectly inhibits sustained development. The deficiencies of the current method of accounting are inconsistent treatment of manmade and natural capital, the omission of natural resources and their depletion from balance sheets, and pollution cleanup costs from national income. In the calculation of GDP pollution is overlooked, and beneficial environmental inputs are valued at zero. The calculation of environmentally adjusted net domestic product (EDP) and environmentally adjusted net income (ENI) would lower income and growth rate, as the World Resources Institute found with respect to Indonesia for 1971-84. When depreciation for oil, timber, and top soil was included the net domestic product (NDP) was only 4% compared with a 7.1% GDP. The World Bank has advocated environmental accounting since 1983 in SNA revisions. The 1989 revised Blue Book of the SNA takes environment concerns into account. Relevant research is under way in Mexico and Papua New Guinea using the UN Statistical Office framework as a system for environmentally adjusted economic accounts that computes EDP and ENI and integrates environmental data with national accounts while preserving SNA concepts.

Effect of elastin-derived peptides on the production of tissue inhibitor of metalloproteinase-1, -2, and -3 and the ratios in various endothelial cell lines.

PubMed

Siemianowicz, Krzysztof; Likus, Wirginia; Francuz, Tomasz; Garczorz, Wojciech

2015-06-01

Tissue inhibitors of metalloproteinases (TIMPs) control the activity of metalloproteinases. Elastin-derived peptides (EDPs) are generated as a result of the degradation of elastin fibers. The EDPs bind to the elastin receptor and exert numerous biological effects. The aim of the present study was to compare the production of TIMP-1, TIMP-2 and TIMP-3 and their ratios in human endothelial cells (ECs) derived from three clinically important vascular localizations (coronary arteries, aorta and iliac artery), and evaluate the influence of a well-known EDP, κ-elastin. The highest concentration of TIMP-1 was identified in the aortic ECs, while the lowest concentration was observed in the ECs derived from the coronary artery. The opposite pattern was observed for TIMP-2 production. When the TIMP-3 concentration was analyzed in the three EC lines, no statistically significant differences were observed. Application of κ-elastin was found to decrease the TIMP-1 concentration in the aortic ECs, while an increase in the TIMP-1 concentration was observed in the ECs derived from the iliac artery. The most significant decrease in TIMP-2 concentration following κ-elastin administration was observed in the ECs obtained from the coronary arteries. Furthermore, the highest concentration of κ-elastin resulted in an increase in TIMP-3 production in the ECs derived from the coronary arteries. The following ratios of the TIMP concentrations were calculated: TIMP-1/TIMP-2, TIMP-1/TIMP-3 and TIMP-2/TIMP-3. Each ratio presented different values for the ECs obtained from the various localizations. In the majority of cases, the addition of κ-elastin did not significantly change these proportions. Therefore, these indicators may be characteristic features that can be used to describe ECs in various clinically important vascular localizations.

Effect of elastin-derived peptides on the production of tissue inhibitor of metalloproteinase-1, -2, and -3 and the ratios in various endothelial cell lines

PubMed Central

SIEMIANOWICZ, KRZYSZTOF; LIKUS, WIRGINIA; FRANCUZ, TOMASZ; GARCZORZ, WOJCIECH

2015-01-01

Tissue inhibitors of metalloproteinases (TIMPs) control the activity of metalloproteinases. Elastin-derived peptides (EDPs) are generated as a result of the degradation of elastin fibers. The EDPs bind to the elastin receptor and exert numerous biological effects. The aim of the present study was to compare the production of TIMP-1, TIMP-2 and TIMP-3 and their ratios in human endothelial cells (ECs) derived from three clinically important vascular localizations (coronary arteries, aorta and iliac artery), and evaluate the influence of a well-known EDP, κ-elastin. The highest concentration of TIMP-1 was identified in the aortic ECs, while the lowest concentration was observed in the ECs derived from the coronary artery. The opposite pattern was observed for TIMP-2 production. When the TIMP-3 concentration was analyzed in the three EC lines, no statistically significant differences were observed. Application of κ-elastin was found to decrease the TIMP-1 concentration in the aortic ECs, while an increase in the TIMP-1 concentration was observed in the ECs derived from the iliac artery. The most significant decrease in TIMP-2 concentration following κ-elastin administration was observed in the ECs obtained from the coronary arteries. Furthermore, the highest concentration of κ-elastin resulted in an increase in TIMP-3 production in the ECs derived from the coronary arteries. The following ratios of the TIMP concentrations were calculated: TIMP-1/TIMP-2, TIMP-1/TIMP-3 and TIMP-2/TIMP-3. Each ratio presented different values for the ECs obtained from the various localizations. In the majority of cases, the addition of κ-elastin did not significantly change these proportions. Therefore, these indicators may be characteristic features that can be used to describe ECs in various clinically important vascular localizations. PMID:26136968

Video-Out Projection and Lecture Hall Set-Up. Microcomputing Working Paper Series.

ERIC Educational Resources Information Center

Gibson, Chris

This paper details the considerations involved in determining suitable video projection systems for displaying the Apple Macintosh's screen to large groups of people, both in classrooms with approximately 25 people, and in lecture halls with approximately 250. To project the Mac screen to groups in lecture halls, the Electrohome EDP-57 video…

40 CFR 60.393 - Performance test and compliance provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... per volume of applied coating solids (G) during each calendar month for each affected facility by the following equation: EC16NO91.030 (E) For each EDP prime coat operation, calculate the turnover ratio (RT) by....392(a). (ii) If the volume weighted average mass of VOC per volume of applied coating solids (G...

Preventing Internal Computer Abuse

DTIC Science & Technology

1986-12-01

abusers of computer systems are individuals who are -’’internal" to and working for the victim organization (these include full-time employees , part...Moonlighting * Organizational Property * Nonuse/nondisclosure * Substance Abuse * Gambling Employee Assistance Program "Whistle Blower" Policy EDP Auditor 1...sensitive computer systems. Of all the controls discussed so far. the Employee Assistance Program ’ EAP

Physical Mechanism of the Lower-Hybrid-Drift Instability in a Collisional Plasma.

DTIC Science & Technology

1981-01-30

8217 70Q SaCE .A-.D A> AT TN R~~ . WIL.IAMRS 01CI " CUT% 755O -řA ol2’ 4’TN E_."D-NP F. WIMItNITZ 01:y A’ ’N. LOGE 02CY ATTN D’E_,D).p C. MOAZED 0:2’ All% c

Introducing Engineering Design to a Science Teaching Methods Course through Educational Robotics and Exploring Changes in Views of Preservice Elementary Teachers

ERIC Educational Resources Information Center

Kaya, Erdogan; Newley, Anna; Deniz, Hasan; Yesilyurt, Ezgi; Newley, Patrick

2017-01-01

Engineering has become an important subject in the Next Generation Science Standards (NGSS), which have raised engineering design to the same level as scientific inquiry when teaching science disciplines at all levels. Therefore, preservice elementary teachers (PSTs) need to know how to integrate the engineering design process (EDP) into their…

Application configuration selection for energy-efficient execution on multicore systems

DOE PAGES

Wang, Shinan; Luo, Bing; Shi, Weisong; ...

2015-09-21

Balanced performance and energy consumption are incorporated in the design of modern computer systems. Several runtime factors, such as concurrency levels, thread mapping strategies, and dynamic voltage and frequency scaling (DVFS) should be considered in order to achieve optimal energy efficiency fora workload. Selecting appropriate run-time factors, however, is one of the most challenging tasks because the run-time factors are architecture-specific and workload-specific. And while most existing works concentrate on either static analysis of the workload or run-time prediction results, we present a hybrid two-step method that utilizes concurrency levels and DVFS settings to achieve the energy efficiency configuration formore » a worldoad. The experimental results based on a Xeon E5620 server with NPB and PARSEC benchmark suites show that the model is able to predict the energy efficient configuration accurately. On average, an additional 10% EDP (Energy Delay Product) saving is obtained by using run-time DVFS for the entire system. An off-line optimal solution is used to compare with the proposed scheme. Finally, the experimental results show that the average extra EDP saved by the optimal solution is within 5% on selective parallel benchmarks.« less

Fingolimod Hydrochloride Gel for Dermatological Applications: Optimization of Formulation Strength and Effect of Colloidal Oatmeal (Aveeno®) as Penetration Enhancer.

PubMed

Tamakuwala, M; Stagni, G

2016-08-01

Fingolimod (FNGL) is an immune-modulatory agent prescribed for relapsing forms of multiple sclerosis. Because of its mechanism of action, FNGL is potentially a treatment for chronic, non-curable T-lymphocyte-driven inflammatory skin diseases (TLDISD) such as psoriasis and atopic dermatitis. Since severe side effects limit the systemic administration of FNGL, the objective of this study is to develop a hydroxypropyl cellulose (2%) FNGL gel for dermatological applications. First, the effect of FNGL strength (0.05%, 0.10%, 0.50%, and 1.00%) on skin permeability and retention was investigated. We carried out several permeation studies with vertical Franz diffusion cells and (i) cellulose or (ii) excised dorsal porcine ear skin (EDPES) as membrane. We also quantified FNGL in the stratum corneum and in dermis with the tape-stripping method. Permeability parameters as well as the amount retained in skin increased significantly (p < 0.01) with strength; however, there was no statistically significant difference between the 0.50% and 1.00% gels for both cellulose and EDPES. Therefore, we selected the 0.50% gel to investigate the effect of colloidal oatmeal (0%, 1%, 3%, 6%, and 10%) on FNGL in vitro permeability and skin retention. Colloidal oatmeal has beneficial dermatological properties for TLDISD and may complement FNGL activity. Permeability increased significantly (p < 0.001) with colloidal oatmeal at the 6% and 10% strength with an enhancement ratio of 3.5 and 2.4, respectively, whereas the amount retained in the skin decreased significantly (p < 0.001) compared to the base gel. In conclusion, the 0.50% FNGL(.)HCL gel with 6% Aveeno® has very promising permeability characteristics for delivery of FNGL to the skin.

Assessment of modal-pushover-based scaling procedure for nonlinear response history analysis of ordinary standard bridges

USGS Publications Warehouse

Kalkan, E.; Kwong, N.

2012-01-01

The earthquake engineering profession is increasingly utilizing nonlinear response history analyses (RHA) to evaluate seismic performance of existing structures and proposed designs of new structures. One of the main ingredients of nonlinear RHA is a set of ground motion records representing the expected hazard environment for the structure. When recorded motions do not exist (as is the case in the central United States) or when high-intensity records are needed (as is the case in San Francisco and Los Angeles), ground motions from other tectonically similar regions need to be selected and scaled. The modal-pushover-based scaling (MPS) procedure was recently developed to determine scale factors for a small number of records such that the scaled records provide accurate and efficient estimates of “true” median structural responses. The adjective “accurate” refers to the discrepancy between the benchmark responses and those computed from the MPS procedure. The adjective “efficient” refers to the record-to-record variability of responses. In this paper, the accuracy and efficiency of the MPS procedure are evaluated by applying it to four types of existing Ordinary Standard bridges typical of reinforced concrete bridge construction in California. These bridges are the single-bent overpass, multi-span bridge, curved bridge, and skew bridge. As compared with benchmark analyses of unscaled records using a larger catalog of ground motions, it is demonstrated that the MPS procedure provided an accurate estimate of the engineering demand parameters (EDPs) accompanied by significantly reduced record-to-record variability of the EDPs. Thus, it is a useful tool for scaling ground motions as input to nonlinear RHAs of Ordinary Standard bridges.

Simulations of simple Bovine and Homo sapiens outer cortex ocular lens membrane models with a majority concentration of cholesterol.

PubMed

Adams, Mark; Wang, Eric; Zhuang, Xiaohong; Klauda, Jeffery B

2017-11-21

The lipid composition of bovine and human ocular lens membranes has been probed, and a variety of lipids have been found including phosphatidylcholine (PC), phosphatidylethanolamine (PE), sphingomyelin (SM), and cholesterol (CHOL) with cholesterol being present in particularly high concentrations. In this study, we use the all-atom CHARMM36 force field to simulate binary, ternary, and quaternary mixtures as models of the ocular lens. High concentration of cholesterol, in combination with different and varying diversity of phospholipids (PL) and sphingolipids (SL), affect the structure of the ocular lens lipid bilayer. The following analyses were done for each simulation: surface area per lipid, component surface area per lipid, deuterium order parameters (S CD ), electron density profiles (EDP), membrane thickness, hydrogen bonding, radial distribution functions, clustering, and sterol tilt angle distribution. The S CD show significant bilayer alignment and packing in cholesterol-rich bilayers. The EDP show the transition from liquid crystalline to liquid ordered with the addition of cholesterol. Hydrogen bonds in our systems show the tendency for intramolecular interactions between cholesterol and fully saturated lipid tails for less complex bilayers. But with an increased number of components in the bilayer, the acyl chain of the lipids becomes a less important characteristic, and the headgroup of the lipid becomes more significant. Overall, cholesterol is the driving force of membrane structure of the ocular lens membrane where interactions between cholesterol, PL, and SL determine structure and function of the biomembrane. The goal of this work is to develop a baseline for further study of more physiologically realistic ocular lens lipid membranes. This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by Marjorie Longo. Copyright © 2017 Elsevier B.V. All rights reserved.

DCAA Contract Audit Manual. Volume 1, Chapters 1 - 11

DTIC Science & Technology

1995-01-01

Office de Carvalho, Jenny Alexandria Branch Office Davids, Steve J. Melbourne Branch Office Dean, Clay Defense Contract Audit Institute Desert Valley...Justice DOL Department of Labor DOT Department of Transportation DPRO Defense Plant Representative Offices EAC Estimate At Completion (Cost) EDP...in the Department of De - vide accounting and financial advisory fense- services regarding contracts and subcon- tracts to all Department of Defense

Integrated Optoelectronic Networks for Application-Driven Multicore Computing

DTIC Science & Technology

2017-05-08

hybrid photonic torus, the all-optical Corona crossbar, and the hybrid hierarchical Firefly crossbar. • The key challenges for waveguide photonics...improves SXR but with relatively higher EDP overhead. Our evaluation results indicate that the encoding schemes improve worst-case-SXR in Corona and...photonic crossbar architectures ( Corona and Firefly) indicate that our approach improves worst-case signal-to-noise ratio (SNR) by up to 51.7

West Europe Report. No. 2189

DTIC Science & Technology

1983-08-12

NOTICIAS, 5 Jul 83) 29 Spreading Tax Evasion Noted, Fiscal Reform Seen Needed (Editorial; DIARIO DE NOTICIAS, 6 Jul 83...in parenthesis. Super gasoline, 84 escudos (74); regular gasoline, 81 escudos (70); kerosene for lamps, 46 escudos (40); kerosene, 47 escudos (41...diesel fuel, 46 escudos (40); fuel oil, one percent, 21 escudos (19); fuel oil, 3.5 percent, 19.50 escudos (17.50); fuel oil, one percent (EDP

Information systems in ADOT : an analysis of intra-function flow, decision support needs, existing systems utility and user attitudes. Final report, volume 2 : manual for evaluation of needs and attitudes of EDP users

DOT National Transportation Integrated Search

1985-03-01

A report is offered on a study of the information activities within the Right-of-Way section of ADOT. The objectives of the study were to adapt and apply techniques to measure user-perceived needs, satisfaction and utility of services provided Right-...

Topography and Higher Order Corneal Aberrations of the Fellow Eye in Unilateral Keratoconus.

PubMed

Aksoy, Sibel; Akkaya, Sezen; Özkurt, Yelda; Kurna, Sevda; Açıkalın, Banu; Şengör, Tomris

2017-10-01

Comparison of topography and corneal higher order aberrations (HOA) data of fellow normal eyes of unilateral keratoconus patients with keratoconus eyes and control group. The records of 196 patients with keratoconus were reviewed. Twenty patients were identified as unilateral keratoconus. The best corrected visual acuity (BCVA), topography and aberration data of the unilateral keratoconus patients' normal eyes were compared with their contralateral keratoconus eyes and with control group eyes. For statistical analysis, flat and steep keratometry values, average corneal power, cylindrical power, surface regularity index (SRI), surface asymmetry index (SAI), inferior-superior ratio (I-S), keratoconus prediction index, and elevation-depression power (EDP) and diameter (EDD) topography indices were selected. Mean age of the unilateral keratoconus patients was 26.05±4.73 years and that of the control group was 23.6±8.53 years (p>0.05). There was no statistical difference in BCVA between normal and control eyes (p=0.108), whereas BCVA values were significantly lower in eyes with keratoconus (p=0.001). Comparison of quantitative topographic indices between the groups showed that all indices except the I-S ratio were significantly higher in the normal group than in the control group (p<0.05). The most obvious differences were in the SRI, SAI, EDP, and EDD values. All topographic indices were higher in the keratoconus eyes compared to the normal fellow eyes. There was no difference between normal eyes and the control group in terms of spherical aberration, while coma, trefoil, irregular astigmatism, and total HOA values were higher in the normal eyes of unilateral keratoconus patients (p<0.05). All HOA values were higher in keratoconus eyes than in the control group. According to our study, SRI, SAI, EDP, EDD values, and HOA other than spherical aberration were higher in the clinically and topographically normal fellow eyes of unilateral keratoconus patients when compared to a control group. This finding may be due to the mild asymmetric and morphologic changes in the subclinical stage of keratoconus leading to deterioration in the indicators of corneal irregularity and elevation changes. Therefore, these eyes may be exhibiting the early form of the disease.

Should ground-motion records be rotated to fault-normal/parallel or maximum direction for response history analysis of buildings?

USGS Publications Warehouse

Reyes, Juan C.; Kalkan, Erol

2012-01-01

In the United States, regulatory seismic codes (for example, California Building Code) require at least two sets of horizontal ground-motion components for three-dimensional (3D) response history analysis (RHA) of building structures. For sites within 5 kilometers (3.1 miles) of an active fault, these records should be rotated to fault-normal and fault-parallel (FN/FP) directions, and two RHAs should be performed separately—when FN and then FP direction are aligned with transverse direction of the building axes. This approach is assumed to lead to two sets of responses that envelope the range of possible responses over all nonredundant rotation angles. The validity of this assumption is examined here using 3D computer models of single-story structures having symmetric (torsionally stiff) and asymmetric (torsionally flexible) layouts subjected to an ensemble of near-fault ground motions with and without apparent velocity pulses. In this parametric study, the elastic vibration period is varied from 0.2 to 5 seconds, and yield-strength reduction factors, R, are varied from a value that leads to linear-elastic design to 3 and 5. Further validations are performed using 3D computer models of 9-story structures having symmetric and asymmetric layouts subjected to the same ground-motion set. The influence of the ground-motion rotation angle on several engineering demand parameters (EDPs) is examined in both linear-elastic and nonlinear-inelastic domains to form benchmarks for evaluating the use of the FN/FP directions and also the maximum direction (MD). The MD ground motion is a new definition for horizontal ground motions for use in site-specific ground-motion procedures for seismic design according to provisions of the American Society of Civil Engineers/Seismic Engineering Institute (ASCE/SEI) 7-10. The results of this study have important implications for current practice, suggesting that ground motions rotated to MD or FN/FP directions do not necessarily provide the most critical EDPs in nonlinear-inelastic domain; however, they tend to produce larger EDPs than as-recorded (arbitrarily oriented) motions.

The Future of Air Traffic Management

NASA Technical Reports Server (NTRS)

Denery, Dallas G.; Erzberger, Heinz; Edwards, Thomas A. (Technical Monitor)

1998-01-01

A system for the control of terminal area traffic to improve productivity, referred to as the Center-TRACON Automation System (CTAS), is being developed at NASA's Ames Research Center under a joint program with the FAA. CTAS consists of a set of integrated tools that provide computer-generated advisories for en-route and terminal area controllers. The premise behind the design of CTAS has been that successful planning of traffic requires accurate trajectory prediction. Data bases consisting of representative aircraft performance models, airline preferred operational procedures and a three dimensional wind model support the trajectory prediction. The research effort has been the design of a set of automation tools that make use of this trajectory prediction capability to assist controllers in overall management of traffic. The first tool, the Traffic Management Advisor (TMA), provides the overall flow management between the en route and terminal areas. A second tool, the Final Approach Spacing Tool (FAST) provides terminal area controllers with sequence and runway advisories to allow optimal use of the runways. The TMA and FAST are now being used in daily operations at Dallas/Ft. Worth airport. Additional activities include the development of several other tools. These include: 1) the En Route Descent Advisor that assist the en route controller in issuing conflict free descents and ascents; 2) the extension of FAST to include speed and heading advisories and the Expedite Departure Path (EDP) that assists the terminal controller in management of departures; and 3) the Collaborative Arrival Planner (CAP) that will assist the airlines in operational decision making. The purpose of this presentation is to review the CTAS concept and to present the results of recent field tests. The paper will first discuss the overall concept and then discuss the status of the individual tools.

[Dento-facial orthopedics and kinesthetic therapy: partners in patient management].

PubMed

Alvarado-Faysse, Caroline

2014-09-01

Orthodontic treatment alone, or combined with maxillo-facial surgery, can benefit from a kinesthetic therapy approach. This method of functional management, set in place as soon as the orthodontic diagnosis is made, will allow for a comprehensive therapeutic approach to patients, marked by a dialogue, between the different players involved in treatment, orthodontists and maxillofacial surgeons who intelligently work in concert. © EDP Sciences, SFODF, 2014.

[Invisible and almost invisible orthodontic appliances].

PubMed

Baron, Pascal

2014-03-01

Patient demand for invisible esthetic orthodontic appliances is steadily increasing. Two types of orthodontic appliances have a high rate of patient acceptance. The lingual technique has continually evolved by offering both prefabricated brackets or custom-made brackets. The various techniques have been improved over time, and the results are better than ever. Thermoplastic aligners are an alternative to lingual devices and their use is rapidly growing. Their specific properties make it easier to assess their indications and limitations. A review of the literature, the development of these systems and a presentation of some clinical examples of treated cases will help us to provide some of the basics for understanding each of these two types of appliances and to demonstrate the advantages and disadvantages of each system. © EDP Sciences, SFODF, 2014.

JPSS Common Ground System Multimission Support

NASA Astrophysics Data System (ADS)

Jamilkowski, M. L.; Miller, S. W.; Grant, K. D.

2013-12-01

NOAA & NASA jointly acquire the next-generation civilian operational weather satellite: Joint Polar Satellite System (JPSS). JPSS contributes the afternoon orbit & restructured NPOESS ground system (GS) to replace the current Polar-orbiting Operational Environmental Satellite (POES) system run by NOAA. JPSS sensors will collect meteorological, oceanographic, climatological & solar-geophysical observations of the earth, atmosphere & space. The JPSS GS is the Common Ground System (CGS), consisting of Command, Control, & Communications (C3S) and Interface Data Processing (IDPS) segments, both developed by Raytheon Intelligence, Information & Services (IIS). CGS now flies the Suomi National Polar-orbiting Partnership (S-NPP) satellite, transfers its mission data between ground facilities and processes its data into Environmental Data Records for NOAA & Defense (DoD) weather centers. CGS will expand to support JPSS-1 in 2017. The JPSS CGS currently does data processing (DP) for S-NPP, creating multiple TBs/day across over two dozen environmental data products (EDPs). The workload doubles after JPSS-1 launch. But CGS goes well beyond S-NPP & JPSS mission management & DP by providing data routing support to operational centers & missions worldwide. The CGS supports several other missions: It also provides raw data acquisition, routing & some DP for GCOM-W1. The CGS does data routing for numerous other missions & systems, including USN's Coriolis/Windsat, NASA's SCaN network (including EOS), NSF's McMurdo Station communications, Defense Meteorological Satellite Program (DMSP), and NOAA's POES & EUMETSAT's MetOp satellites. Each of these satellite systems orbits the Earth 14 times/day, downlinking data once or twice/orbit at up to 100s of MBs/second, to support the creation of 10s of TBs of data/day across 100s of EDPs. Raytheon and the US government invested much in Raytheon's mission-management, command & control and data-processing products & capabilities. CGS's flexible, multimission capabilities offer major chances for cost reduction & improved information integration across missions. Raytheon has a unique ability to provide complex, highly-secure, multi-mission GSs. As disaggregation, hosted CGS multimission payloads, and other space-architecture trades are implemented and new sensors come on line that collect orders of magnitude more data, the importance of a flexible, expandable and virtualized modern GS architecture increases. The CGS offers that solution support. JPSS CGS supports 5 global ground stations that can receive S-NPP & JPSS-1 mission data. These, linked with high-bandwidth commercial fiber, quickly transport data to the IDPS for EDP creation & delivery. CGS will process & deliver JPSS-1 data to US operational users in < 80 minutes from time of collection. And CGS leverages this fiber network to provide added data routing for a wide array of global missions. The JPSS CGS is a mature, tested solution for support to operational weather forecasting for civil, military and international partners and climate research. It features a flexible design handling order-of-magnitude increases in data over legacy satellite GSs and meets demanding science accuracy needs. The Raytheon-built JPSS CGS gives the full GS capability, from design & development through operations & sustainment. This lays the foundation for CGS future evolution to support additional missions like Polar Free Flyers.

Investigation of Ionospheric Precursors of 23 October 2011, Mw=7.2 Earthquake in Van, Turkey

NASA Astrophysics Data System (ADS)

Deviren, M. N.; Arikan, F.; Sezen, U.; Arikan, O.

2012-04-01

In recent years, a strong coupling between ionospheric disturbances and seismic activity has been observed through the increase of ion temperatures, critical frequencies of ionospheric layers and Total Electron Content (TEC) before high magnitude earthquakes. TEC is defined as total number of electrons over a ray path through the ionosphere. TEC can be estimated in a cost-effective way with dual-frequency Global Positioning Satellite (GPS) System receivers. The unit of TEC is given by TECU where 1 TECU = 1016 el/m2. In this study, the disturbances in daily TEC values before 23 October 2011, Mw=7.2 Earthquake in Van, Turkey are investigated using Turkish National Permanent GPS Network (TNPGN-Active). Earthquake Day Period (EDP) is chosen between October 1 and 31, 2011. Daily TEC values, for each station and each day, are estimated as IONOLAB-TEC (www.ionolab.org ) with 30 s time resolution. EDP-TEC values are compared with an Average Quiet Day TEC (AQDT) which is obtained by averaging the TEC values between 25 and 28 March, 2011. Statistical comparison is accomplished using Symmetric Kullback-Leibler Divergence (SKLD), which is also a method for measuring entropy of a system. It has been previously observed that SKLD is a better method for measuring the amount of disturbances compared to L2 norm and cross-correlation coefficient. AQDT is also compared with magnetically Quiet Day Period (QDP) from 25 to 28 April, 2011, during which Kp and Dst indices indicate a very quiet ionospheric and magnetospheric period. Also, in order to measure the variability between the consecutive days, TEC values for each day during EDP and QDP are compared with the TEC values of the following day. A third measure of W-index is also applied to identify the local disturbances in the ionosphere, where TEC of a given day is compared to the median of seven days prior to the day of investigation logarithmically. Since W-index is obtained for each epoch, the within-the-day variability can also be monitored. It has been observed that peak TEC values for all stations in TNPGN increase 10 to 15 TECU two days prior to the earthquake. The SKLD values for comparison of EDP and AQDT also peak on 21st of October, 2011, two days prior to the earthquake. Since ionospheric disturbance can be observed on all days prior to the earthquake, comparison of TEC for consecutive days for each station using SKLD does not provide extra information. The W-index values indicate that there may be small scale variability for stations closer to the earthquake epicenter. When compared with previous earthquakes that occurred in Turkey with magnitudes 4.5 and 5.2 on Richter scale, this 7.2 magnitude earthquake has been felt as an ionospheric disturbance for stations especially on Northern Anatolian Fault. The results also indicate the need for constant monitoring and statistical decision theory for detection of earthquake precursors. This study is supported by TUBITAK EEEAG Grant 109E055.

Work fluctuations for a Brownian particle between two thermostats

NASA Astrophysics Data System (ADS)

Visco, Paolo

2006-06-01

We explicitly determine the large deviation function of the energy flow of a Brownian particle coupled to two heat baths at different temperatures. This toy model, initially introduced by Derrida and Brunet (2005, Einstein aujourd'hui (Les Ulis: EDP Sciences)), not only allows us to sort out the influence of initial conditions on large deviation functions but also allows us to pinpoint various restrictions bearing upon the range of validity of the Fluctuation Relation.

Serum levels of brain-derived neurotrophic factor (BNDF) in multiple sclerosis patients with Trichuris suis ova therapy.

PubMed

Rosche, Berit; Werner, Jonas; Benzel, Friderike Joëlle; Harms, Lutz; Danker-Hopfe, Heidi; Hellweg, Rainer

2013-01-01

We previously analysed clinical and immunological parameters under Trichuris suis ova (TSO) therapy in four patients with secondary progressive multiple sclerosis. The serum Brain-derived neurotrophic factor (BDNF) levels of these four patients were assessed before, during and after therapy with TSO and showed significant decrease of BDNF during TSO therapy (p < 0.05). © B. Rosche et al., published by EDP Sciences, 2013.

Structures and Techniques For Implementing and Packaging Complex, Large Scale Microelectromechanical Systems Using Foundry Fabrication Processes.

DTIC Science & Technology

1996-06-01

switches 5-43 Figure 5-27. Mechanical interference between ’Pull Spring’ devices 5-45 Figure 5-28. Array of LIGA mechanical relay switches 5-49...like coating DM Direct metal interconnect technique DMD ™ Digital Micromirror Device EDP Ethylene, diamine, pyrocatechol and water; silicon anisotropic...mechanical systems MOSIS MOS Implementation Service PGA Pin grid array, an electronic die package PZT Lead-zirconate-titanate LIGA Lithographie

Determination of Ionospheric Electron Density Profiles from Satellite UV (Ultraviolet) Emission Measurements, Fiscal Year 1984.

DTIC Science & Technology

1985-04-26

distribution function. It is from the calculated distribution function that the photoelectron flux can be derived. The VUV daytime emissions that we are...OECLASSIPICATIONUOOWNdGRADING SCHEDULE Apoe o ulcrlae N/A distribution unlimited .PE RPORMING ORGANIZATION REPORT NUMBER41S( 5. MONITORING ORGANIZATION REPORT...EDP for systems users. This report considers the following ionospheric subregions: (a) the daytime mid- latitude ionosphere from, 90 to 1000 km, (b

Rocky Mountain Arsenal Ecological Chemical Data (1984-1985)

DTIC Science & Technology

1986-03-01

Type Wet Areas Code Area LK Lake MT Marshy Type PD Pond C-1 APPENDIX D TISSUE CODES Code Tissue BRA Brain FIL Filet EDP Edible Portion LIV Liver MUS...ctus 472 Craton texcisis Crotoni 473 Cryptantha fcndleri Fcnder’s Cryptantha 474 Cucurbita foctidissinma Wild Gourd 475 Cytroptcrus montanus Pink Cym...adcrnocaulon Nlorthern wilIlow- herb 484 Eragrostis cilianensis Stinkgrass 485 Erfcgonum annuum Tall Erlogonum 486 Erigercn divergcns Spreading Fleabine 487

[Skeletal anchorage in the past, today and tomorrow].

PubMed

Melsen, Birte; Dalstra, Michel

2017-03-01

Skeletal anchorage was not introduced as an alternative to conventional anchorage modalities. The first skeletal anchorage was a ligature through a hole in the infrazygomatic crest. This was replaced by surgical screws and finally the TADs, which were optimized with respect to the material and morphology, were developed. A bracket-like head allows for the use of the mini-implant as indirect anchorage, but should not be a tool for lost control resulting from badly planned biomechanics or failing compliance. Skeletal anchorage should serve as an adjunct to correct biomechanics, to enable treatments that could not be performed prior to the introduction of skeletal anchorage. The aim of this study was to test the hypothesis that temporary anchorage mini-screws help maintain bone density, height and width of alveolar processes in the extraction sites, and thus prevent the thinning of the alveolar ridge usually observed. In adult patients with degenerated dentitions the application of skeletal anchorage can allow for the displacement of teeth where no anchorage units are present, but also for the redevelopment and maintenance of atrophic alveolar bone. The basis for the optimal use of skeletal anchorage is that the correct line of action for the desired tooth displacement is defined and the necessary force system constructed either with the skeletal anchorage as direct or as indirect anchorage. After a period, during which osseointegrated implants were used as anchorage for tooth movement and bone maintenance, it was accepted that the mini-implants could serve also as anchorage for skeletal displacements avoiding loading of teeth. © EDP Sciences, SFODF, 2017.

Simulating the elimination of sleeping sickness with an agent-based model.

PubMed

Grébaut, Pascal; Girardin, Killian; Fédérico, Valentine; Bousquet, François

2016-01-01

Although Human African Trypanosomiasis is largely considered to be in the process of extinction today, the persistence of human and animal reservoirs, as well as the vector, necessitates a laborious elimination process. In this context, modeling could be an effective tool to evaluate the ability of different public health interventions to control the disease. Using the Cormas ® system, we developed HATSim, an agent-based model capable of simulating the possible endemic evolutions of sleeping sickness and the ability of National Control Programs to eliminate the disease. This model takes into account the analysis of epidemiological, entomological, and ecological data from field studies conducted during the last decade, making it possible to predict the evolution of the disease within this area over a 5-year span. In this article, we first present HATSim according to the Overview, Design concepts, and Details (ODD) protocol that is classically used to describe agent-based models, then, in a second part, we present predictive results concerning the evolution of Human African Trypanosomiasis in the village of Lambi (Cameroon), in order to illustrate the interest of such a tool. Our results are consistent with what was observed in the field by the Cameroonian National Control Program (CNCP). Our simulations also revealed that regular screening can be sufficient, although vector control applied to all areas with human activities could be significantly more efficient. Our results indicate that the current model can already help decision-makers in planning the elimination of the disease in foci. © P. Grébaut et al., published by EDP Sciences, 2016.

Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega − 3 polyunsaturated fatty acids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agbor, Larry N.; Walsh, Mary T.; Boberg, Jason R.

In vitro cytochrome P4501A1 (CYP1A1) metabolizes omega − 3 polyunsaturated fatty acids (n − 3 PUFAs); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), primarily to 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP), respectively. These metabolites have been shown to mediate vasodilation via increases in nitric oxide (NO) and activation of potassium channels. We hypothesized that genetic deletion of CYP1A1 would reduce vasodilatory responses to n − 3 PUFAs, but not the metabolites, and increase blood pressure (BP) due to decreases in NO. We assessed BP by radiotelemetry in CYP1A1 wildtype (WT) and knockout (KO) mice ± NO synthase (NOS) inhibitor.more » We also assessed vasodilation to acetylcholine (ACh), EPA, DHA, 17,18-EEQ and 19,20-EDP in aorta and mesenteric arterioles. Further, we assessed vasodilation to an NO donor and to DHA ± inhibitors of potassium channels. CYP1A1 KO mice were hypertensive, compared to WT, (mean BP in mm Hg, WT 103 ± 1, KO 116 ± 1, n = 5/genotype, p < 0.05), and exhibited a reduced heart rate (beats per minute, WT 575 ± 5; KO 530 ± 7; p < 0.05). However, BP responses to NOS inhibition and vasorelaxation responses to ACh and an NO donor were normal in CYP1A1 KO mice, suggesting that NO bioavailability was not reduced. In contrast, CYP1A1 KO mice exhibited significantly attenuated vasorelaxation responses to EPA and DHA in both the aorta and mesenteric arterioles, but normal vasorelaxation responses to the CYP1A1 metabolites, 17,18-EEQ and 19,20-EDP, and normal responses to potassium channel inhibition. Taken together these data suggest that CYP1A1 metabolizes n − 3 PUFAs to vasodilators in vivo and the loss of these vasodilators may lead to increases in BP. -- Highlights: ► CYP1A1 KO mice are hypertensive. ► CYP1A1 KO mice exhibit reduced vasodilation responses to n-3 PUFAs. ► Constitutive CYP1A1 expression regulates blood pressure and vascular function.« less

Post-hypothermic cardiac left ventricular systolic dysfunction after rewarming in an intact pig model

PubMed Central

2010-01-01

Introduction We developed a minimally invasive, closed chest pig model with the main aim to describe hemodynamic function during surface cooling, steady state severe hypothermia (one hour at 25°C) and surface rewarming. Methods Twelve anesthetized juvenile pigs were acutely catheterized for measurement of left ventricular (LV) pressure-volume loops (conductance catheter), cardiac output (Swan-Ganz), and for vena cava inferior occlusion. Eight animals were surface cooled to 25°C, while four animals were kept as normothermic time-matched controls. Results During progressive cooling and steady state severe hypothermia (25°C) cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), maximal deceleration of pressure in the cardiac cycle (dP/dtmin), indexes of LV contractility (preload recruitable stroke work, PRSW, and maximal acceleration of pressure in the cardiac cycle, dP/dtmax) and LV end diastolic and systolic volumes (EDV and ESV) were significantly reduced. Systemic vascular resistance (SVR), isovolumetric relaxation time (Tau), and oxygen content in arterial and mixed venous blood increased significantly. LV end diastolic pressure (EDP) remained constant. After rewarming all the above mentioned hemodynamic variables that were depressed during 25°C remained reduced, except for CO that returned to pre-hypothermic values due to an increase in heart rate. Likewise, SVR and EDP were significantly reduced after rewarming, while Tau, EDV, ESV and blood oxygen content normalized. Serum levels of cardiac troponin T (TnT) and tumor necrosis factor-alpha (TNF-α) were significantly increased. Conclusions Progressive cooling to 25°C followed by rewarming resulted in a reduced systolic, but not diastolic left ventricular function. The post-hypothermic increase in heart rate and the reduced systemic vascular resistance are interpreted as adaptive measures by the organism to compensate for a hypothermia-induced mild left ventricular cardiac failure. A post-hypothermic increase in TnT indicates that hypothermia/rewarming may cause degradation of cardiac tissue. There were no signs of inadequate global oxygenation throughout the experiments. PMID:21092272

Regional 3-D ionospheric electron density specification on the basis of data assimilation of ground-based GNSS and radio occultation data

NASA Astrophysics Data System (ADS)

Aa, Ercha; Liu, Siqing; Huang, Wengeng; Shi, Liqin; Gong, Jiancun; Chen, Yanhong; Shen, Hua; Li, Jianyong

2016-06-01

In this paper, a regional 3-D ionospheric electron density specification over China and adjacent areas (70°E-140°E in longitude, 15°N-55°N in latitude, and 100-900 km in altitude) is developed on the basis of data assimilation technique. The International Reference Ionosphere (IRI) is used as a background model, and a three-dimensional variational technique is used to assimilate both the ground-based Global Navigation Satellite System (GNSS) observations from the Crustal Movement Observation Network of China (CMONOC) and International GNSS Service (IGS) and the ionospheric radio occultation (RO) data from FORMOSAT-3/COSMIC (F3/C) satellites. The regional 3-D gridded ionospheric electron densities can be generated with temporal resolution of 5 min in universal time, horizontal resolution of 2° × 2° in latitude and longitude, and vertical resolution of 20 km between 100 and 500 km and 50 km between 500 and 900 km. The data assimilation results are validated through extensive comparison with several sources of electron density information, including (1) ionospheric total electron content (TEC); (2) Abel-retrieved F3/C electron density profiles (EDPs); (3) ionosonde foF2 and bottomside EDPs; and (4) the Utah State University Global Assimilation of Ionospheric Measurements (USU-GAIM) under both geomagnetic quiet and disturbed conditions. The validation results show that the data assimilation procedure pushes the climatological IRI model toward the observation, and a general accuracy improvement of 15-30% can be expected. Thecomparisons also indicate that the data assimilation results are more close to the Center for Orbit Determination of Europe (CODE) TEC and Madrigal TEC products than USU-GAIM. These initial results might demonstrate the effectiveness of the data assimilation technique in improving specification of local ionospheric morphology.

40 CFR Appendix III to Part 86 - Constant Volume Sampler Flow Calibration

Code of Federal Regulations, 2014 CFR

2014-07-01

... ETI °F ±.1°F. Pressure depression upstream of LFE EPI “H20 ±.1“H20. Pressure drop across the LFE matrix EDP “H20 ±.005“H20. Air temperature at CVS pump inlet PTI °F ±.5°F. Pressure depression at CVS... condition in an increment of pump inlet depression (about 4″ H2O) that will yield a minimum of six data...

40 CFR Appendix III to Part 86 - Constant Volume Sampler Flow Calibration

Code of Federal Regulations, 2010 CFR

2010-07-01

... ETI °F ±.1 °F. Pressure depression upstream of LFE EPI “H20 ±.1“H20. Pressure drop across the LFE matrix EDP “H20 ±.005“H20. Air temperature at CVS pump inlet PTI °F ±.5 °F. Pressure depression at CVS... condition in an increment of pump inlet depression (about 4″ H2O) that will yield a minimum of six data...

40 CFR Appendix III to Part 86 - Constant Volume Sampler Flow Calibration

Code of Federal Regulations, 2013 CFR

2013-07-01

... ETI °F ±.1 °F. Pressure depression upstream of LFE EPI “H20 ±.1“H20. Pressure drop across the LFE matrix EDP “H20 ±.005“H20. Air temperature at CVS pump inlet PTI °F ±.5 °F. Pressure depression at CVS... condition in an increment of pump inlet depression (about 4″ H2O) that will yield a minimum of six data...

40 CFR Appendix III to Part 86 - Constant Volume Sampler Flow Calibration

Code of Federal Regulations, 2011 CFR

2011-07-01

... ETI °F ±.1 °F. Pressure depression upstream of LFE EPI “H20 ±.1“H20. Pressure drop across the LFE matrix EDP “H20 ±.005“H20. Air temperature at CVS pump inlet PTI °F ±.5 °F. Pressure depression at CVS... condition in an increment of pump inlet depression (about 4″ H2O) that will yield a minimum of six data...

40 CFR Appendix III to Part 86 - Constant Volume Sampler Flow Calibration

Code of Federal Regulations, 2012 CFR

2012-07-01

... ETI °F ±.1 °F. Pressure depression upstream of LFE EPI “H20 ±.1“H20. Pressure drop across the LFE matrix EDP “H20 ±.005“H20. Air temperature at CVS pump inlet PTI °F ±.5 °F. Pressure depression at CVS... condition in an increment of pump inlet depression (about 4″ H2O) that will yield a minimum of six data...

Multiphase Modeling of Water Injection on Flame Deflector

NASA Technical Reports Server (NTRS)

Vu, Bruce T.; Bachchan, Nili; Peroomian, Oshin; Akdag, Vedat

2013-01-01

This paper describes the use of an Eulerian Dispersed Phase (EDP) model to simulate the water injected from the flame deflector and its interaction with supersonic rocket exhaust from a proposed Space Launch System (SLS) vehicle. The Eulerian formulation, as part of the multi-phase framework, is described. The simulations show that water cooling is only effective over the region under the liquid engines. Likewise, the water injection provides only minor effects over the surface area under the solid engines.

Relationship Between Job Satisfaction and Career Intent of D.P. Personnel in the Korean Military E.D.P. System.

DTIC Science & Technology

1980-03-01

sincere appreciation to those persons who have been always around me in my mind and in their mind. I wish to thank my thesis advisor, Professor Charles W...different environments. Individual behavior in organizations is a function of the person and of his or her environmental situation (Ref 3:217). The...satisfaction is defined by Robert Hoppock as follows: "Any combination of psychological, physiological, and environmental circumstances that causes a person

[Methodology for clinical research in Orthodontics, the assets of the beOrtho website].

PubMed

Ruiz, Martial; Thibult, François

2014-06-01

The rules applying to the "evidence-based" methodology strongly influenced the clinical research in orthodontics. However, the implementation of clinical studies requires rigour, important statistical and methodological knowledge, as well as a reliable environment in order to compile and store the data obtained from research. We developed the project "beOrtho.com" (based on orthodontic evidence) in order to fill up the gap between our desire to drive clinical research and the necessity of methodological rigour in the exploitation of its results. BeOrtho website was created to answer the issue of sample recruitment, data compilation and storage, while providing help for the methodological design of clinical studies. It allows the development and monitoring of clinical studies, as well as the creation of databases. On the other hand, we designed an evaluation grid for clinical studies which helps developing systematic reviews. In order to illustrate our point, we tested a research protocol evaluating the interest of the mandibular advancement in the framework of Class II treatment. © EDP Sciences, SFODF, 2014.

[A perspective on the use of bone anchorage as opposed to other types of anchorage techniques].

PubMed

Le Gall, Michel; Chevalier, Émilie; Bachet, Christophe; Dameron, Cyril; Dorison-Bachet, Damienne; Philip-Alliez, Camille

2016-12-01

To convert our objectives into the desired treatment results, we need to control our mechanics and thus the anchorage used by avoiding any unwanted movements. It now seems unthinkable, at the dawn of the 21 st century, to ignore the useful contribution of orthodontic screw-borne anchorage. Nevertheless, we are entitled to raise a number of legitimate questions. Do these forms of anchorage offer an alternative to all types of mechanics? Will they permit us to manage clinical situations which are beyond the scope of a more classical approach? Can they enhance the quality of our treatments? Each of the authors describes clinical situations using screw-borne anchorage and compares with a conventional approach in order to make a non-exhaustive analysis of the mechanics applied, in their own office, and then highlights the most effective technique. With 15 years experience in the use of miniscrews, orthodontists have now adopted them with their many advantages as an integral item in their therapeutic armamentarium. However, treatment plans must be coherent. Our mechanics must be well thought-out and represent a cogent entity under the control of the practitioner. Creating screw-borne anchorage demands total control over anchorage stability. © EDP Sciences, SFODF, 2016.

[Muscle and function management by the physiotherapist in orthodontic and orthodonto-surgical treatment. Oral myofunctional rehabilitation].

PubMed

Girard, Marion; Leroux, Claire

2015-03-01

Can we hope to dispense with muscle and function management in orthodontic and orthodonto-surgical treatment plans? How can the specialized physiotherapist assist, facilitate and stabilize the work done by the orthodontist and maxillo-facial surgeon and help avoid relapses? Treatment aims to achieve dental alignment and occlusal balance in direct association with balance of the tongue muscles, cutaneous muscles, masticatory and postural muscles and functions in the orofacial region. Restoration of balance between agonist and antagonist muscles is achieved by relaxing contracted muscles and by gradually building up weak muscle tone. If effective and lasting treatment results are to be obtained, active patient participation is mandatory during rehabilitation of oro-maxillo-facial disorders and must encompass the tongue, lips, cheeks, masticatory system, ventilation and general posture as well as management of the parafunctions. These procedures are essential in dentofacial orthopedic treatment of both children and adults. Practical cases will be used to demonstrate the contribution that myofunctional rehabilitation can make. Regarding natural functions, very satisfactory results are obtained provided patients do daily muscle exercises and day-long training in the correct postures and practical drills they have been taught over a period of at least six months and under the supervision of the physiotherapist. © EDP Sciences, SFODF, 2015.

Development and Verification of the Soil-Pile Interaction Extension for SubDyn

DOE Office of Scientific and Technical Information (OSTI.GOV)

Damiani, Rick R; Wendt, Fabian F

SubDyn is the substructure structural-dynamics module for the aero-hydro-servo-elastic tool FAST v8. SubDyn uses a finite-element model (FEM) to simulate complex multimember lattice structures connected to conventional turbines and towers, and it can make use of the Craig-Bampton model reduction. Here we describe the newly added capability to handle soil-pile stiffness and compare results for monopile and jacket-based offshore wind turbines as obtained with FAST v8, SACS, and EDP (the latter two are modeling software packages commonly used in the offshore oil and gas industry). The level of agreement in terms of modal properties and loads for the entire offshoremore » wind turbine components is excellent, thus allowing SubDyn and FAST v8 to accurately simulate offshore wind turbines on fixed-bottom structures and accounting for the effect of soil dynamics, thus reducing risk to the project.« less

A Monte Carlo and experimental investigation of the dosimetric behavior of low- and medium-perturbation diodes used for entrance in vivo dosimetry in megavoltage photon beams.

PubMed

Mosleh-Shirazi, Mohammad Amin; Karbasi, Sareh; Shahbazi-Gahrouei, Daryoush; Monadi, Shahram

2012-11-08

Full buildup diodes can cause significant dose perturbation if they are used on most or all of radiotherapy fractions. Given the importance of frequent in vivo measurements in complex treatments, using thin buildup (low-perturbation) diodes instead is gathering interest. However, such diodes are strictly unsuitable for high-energy photons; therefore, their use requires evaluation and careful measurement of correction factors (CFs). There is little published data on such factors for low-perturbation diodes, and none on diode characterization for 9 MV X-rays. We report on MCNP4c Monte Carlo models of low-perturbation (EDD5) and medium-perturbation (EDP10) diodes, and a comparison of source-to-surface distance, field size, temperature, and orientation CFs for cobalt-60 and 9 MV beams. Most of the simulation results were within 4% of the measurements. The results suggest against the use of the EDD5 in axial angles beyond ± 50° and exceeding the range 0° to +50° tilt angle at 9 MV. Outside these ranges, although the EDD5 can be used for accurate in vivo dosimetry at 9 MV, its CF variations were found to be 1.5-7.1 times larger than the EDP10 and, therefore, should be applied carefully. Finally, the MCNP diode models are sufficiently reliable tools for independent verification of potentially inaccurate measurements.

Adjustments of the TaD electron density reconstruction model with GNSS-TEC parameters for operational application purposes

NASA Astrophysics Data System (ADS)

Kutiev, Ivan; Marinov, Pencho; Fidanova, Stefka; Belehaki, Anna; Tsagouri, Ioanna

2012-12-01

Validation results on the latest version of TaD model (TaDv2) show realistic reconstruction of the electron density profiles (EDPs) with an average error of 3 TECU, similar to the error obtained from GNSS-TEC calculated paremeters. The work presented here has the aim to further improve the accuracy of the TaD topside reconstruction, adjusting the TEC parameter calculated from TaD model with the TEC parameter calculated by GNSS transmitting RINEX files provided by receivers co-located with the Digisondes. The performance of the new version is tested during a storm period demonstrating further improvements in respect to the previous version. Statistical comparison of modeled and observed TEC confirms the validity of the proposed adjustment. A significant benefit of the proposed upgrade is that it facilitates the real-time implementation of TaD. The model needs a reliable measure of the scale height at the peak height, which is supposed to be provided by Digisondes. Oftenly, the automatic scaling software fails to correctly calculate the scale height at the peak, Hm, due to interferences in the receiving signal. Consequently the model estimated topside scale height is wrongly calculated leading to unrealistic results for the modeled EDP. The proposed TEC adjustment forces the model to correctly reproduce the topside scale height, despite the inaccurate values of Hm. This adjustment is very important for the application of TaD in an operational environment.

Reintroduction of the invasive mosquito species Aedes albopictus in Belgium in July 2013.

PubMed

Boukraa, Slimane; Raharimalala, Fara N; Zimmer, Jean-Yves; Schaffner, Francis; Bawin, Thomas; Haubruge, Eric; Francis, Frédéric

2013-01-01

Since its first report in 2000, the invasive mosquito Aedes albopictus was not found any more during the different entomological inspections performed at its place of introduction in Belgium between 2001 and 2012. In July 2013, one adult male was captured at the same site (a platform of imported used tires located in Vrasene, Oost-Vlaanderen Province), during a monitoring using CO2-baited trap. This finding suggests the reintroduction of the species in Belgium via the used tire trade. © S. Boukraa et al., published by EDP Sciences, 2013.

[Effect of dental arch length decrease during orthodontic treatment in the upper airway development. A review].

PubMed

Haddad, Stéphanie; Kerbrat, Jean-Baptiste; Schouman, Thomas; Goudot, Patrick

2017-03-01

A possible relation between an upper airway space decrease and the development of obstructive sleep apnea syndrom explains the importance to know the effect of the modification of dental arch length on the upper airway during orthodontic treatment. The aim of this article is to expose recent knowledge about upper airway development and dental arch length decrease factors, to determine the influence of this decrease on upper airway development. A review was done to determine the upper airway normal development, to define dental arch to specify if an ideal position of dental arch on apical base exists. All of the length dental arch decrease factors during orthodontic treatment (dental extraction, dental agenesis and dental malpositions) and their upper airway resounding were searched. Some authors found a diminution of upper airway space after premolars extractions while others didn't found this diminution after extractions premolars when incisor retraction is finished. A decrease of transversal maxillary diameter and nasal cavity may be due to absence of permanent teeth. The effect of dental arch length decrease during orthodontic treatment in the upper airway development was not scientifically proved. However we had to be vigilant and adapt our orthodontic treatment case by case to avoid an upper airway modification. © EDP Sciences, SFODF, 2017.

A Monte Carlo and experimental investigation of the dosimetric behavior of low‐ and medium‐perturbation diodes used for entrance in vivo dosimetry in megavoltage photon beams

PubMed Central

Mosleh‐Shirazi, Mohammad Amin; Shahbazi‐Gahrouei, Daryoush; Monadi, Shahram

2012-01-01

Full buildup diodes can cause significant dose perturbation if they are used on most or all of radiotherapy fractions. Given the importance of frequent in vivo measurements in complex treatments, using thin buildup (low‐perturbation) diodes instead is gathering interest. However, such diodes are strictly unsuitable for high‐energy photons; therefore, their use requires evaluation and careful measurement of correction factors (CFs). There is little published data on such factors for low‐perturbation diodes, and none on diode characterization for 9 MV X‐rays. We report on MCNP4c Monte Carlo models of low‐perturbation (EDD5) and medium‐perturbation (EDP10) diodes, and a comparison of source‐to‐surface distance, field size, temperature, and orientation CFs for cobalt‐60 and 9 MV beams. Most of the simulation results were within 4% of the measurements. The results suggest against the use of the EDD5 in axial angles beyond ±50° and exceeding the range 0° to +50° tilt angle at 9 MV. Outside these ranges, although the EDD5 can be used for accurate in vivo dosimetry at 9 MV, its CF variations were found to be 1.5–7.1 times larger than the EDP10 and, therefore, should be applied carefully. Finally, the MCNP diode models are sufficiently reliable tools for independent verification of potentially inaccurate measurements. PACS numbers: 87.10.Rt; 87.50.cm; 87.55.km; 87.56.Fc PMID:23149783

X-ray Reflectivity Study of Ionic Liquids at Electrified Surfaces

NASA Astrophysics Data System (ADS)

Chu, Miaoqi

X-ray reflectivity (XRR) versatile technique that characterize the surface structures. However, due to the lack of phase information of X-ray data, the reconstruction of electron density profile (EDP) from XRR data is an ill-posed inverse problem that requires extra attention. In Chapter 1, several key concepts in XRR data analysis are reviewed. The typical XRR data acquisition procedure and methods of modeling electron density are introduced. The widely used logarithm form of merit function is justified with mathematical deduction and numerical experiment. A scheme that generates artificial reflectivity data with theoretical statistical error but not systematical error is proposed. With the methods and schemes described in Chapter 1, simulated reflectivity data of a simple one-slab model is generated and fitted to test the efficient of EDP reconstruction. By isolating the parameters, the effects of slab width, electron density contrast and maximal wave transfer are studied individually. It?s demonstrated that best-fit/global minima, result reported by most XRR studies, don?t necessary reflect the real EDP. By contrast, mapping the merit function in the parametric space can capture much more details. Additionally, the widely accepted concept about the XRR theoretical spatial resolution (pi/q_{max}) as well the using Patterson function are brought to test. In the perspective of XRR data analysis, this chapter puts forward general rules to design and optimize XRR experiments. It also demonstrates how susceptible the fitting result will be if it?s not done carefully. In Chapter 3, the interface between hydrophobic OTS film and several solvents is studied with XRR in a transmission-cell setup. The solvents, from water, acetone, to alcohol (methanol, ethanol, 1-propanol), to alkane (pentane, hexane and heptane), vary significantly in terms of polarity and hydrogen bonding. However, the XRR data from different solvents are subtle. The methods and principles elicited in previous chapters are employed to extract information about the solid-liquid interface. Electron density depletion due to methyl terminal of solvent molecules (methyl gap) and due to the reduced surface density compared to the bulk density (density gap) are analyzed. In the next Chapter, XRR technique is employed to study the structures and dynamics of room temperature ionic liquids (RTILs) at an electrified surface. RTILs are molten salts at room temperature, consisted purely by anions and cations, with potential applications in energy storage, electro-synthesis, electrodeposition etc. The solvent-free and high charge concentrated novel liquids process many unique properties that not seen in normal dilute salt solution. It is predicted that when a surface isn't highly charged, RTILs form alternating layers of anion/cation to screen the surface charge; when it's highly charged, a crowding layer with ions with like charge forms. The alternating structure has been observed experimentally but not the crowding layer. Following the rules of optimization XRR experiment in Chapter 2, conductive silicon which has small electron density is used which maximize the EDP contrast. This makes it possible to directly observe the formation of crowding layer. The thickness of this crowding layer, charge distributions and compositions as a function of applied voltage. The dynamics of anion/cation reorganization in RTILs determine the power density for RTILs? energy application. In Chapter 5, the time-dependence of the formation and dissipation of the crowding layer is studied with XRR. An ultra-slow dynamic, much longer than the typical RC time constant, is revealed. Comparisons with theoretical predications and experiments studies are made in order to understand the origin of this process. The thesis is summarized in Chapter 6, along with several proposals for future work.

[Reversible damages: loss of chance].

PubMed

Béry, Alain

2013-03-01

Chance is the probability that a particular event may or may not occur and, in this sense, a loss of chance∗∗ can be defined as the missed opportunities resulting from the loss of the possibility that a favorable event will occur (a contrario, the failure to take risks)∗∗∗. This is a self-imposed liability that should be distinguished from the final damage. Moral damage is a notion that is very close to loss of chance although it is based on indemnification from the final damage of an affliction or malady. © EDP Sciences, SFODF, 2013.

Localization of excitons by molecular layer formation in a polymer film

NASA Astrophysics Data System (ADS)

Chattopadhyay, S.; Datta, A.

2005-10-01

Spin coated films of atactic polystyrene of two different molecular weights have been studied with uv spectroscopy and x-ray reflectivity, the film thickness (d) varying from ˜2Rg to ˜12Rg where Rg is the unperturbed radius of gyration of the polymer. uv extinction due to the pure electronic singlet A1g1→E1u1 is seen to increase with d-1 for 4Rg⩽d⩽12Rg (region 1). This suggests excitonic interaction along d . The variation of total exciton energy (E) of the A1g→E1u singlet with d in region 1 can be well explained by formation of linear J -aggregates of polystyrene molecules, in a lattice with spacing “ a ” (in Å) Rg0 at d≃4Rg , where the exciton is still delocalized. Layering reduces the Hamaker constant (AH) , deciding the cohesive force, between the layers and this reduction, ΔAH , is found to be less than Ae at d⩾4Rg , where iAe/ℏ is the amplitude for exciton transfer between neighboring molecules in the excitonic lattice of region 1. On the other hand, ΔAH in region 2 starts from a value larger than Ae . This indicates that ΔAH acts as a barrier between the layer, which localizes the exciton within the layers.

A new data management system for the French National Registry of human alveolar echinococcosis cases.

PubMed

Charbonnier, Amandine; Knapp, Jenny; Demonmerot, Florent; Bresson-Hadni, Solange; Raoul, Francis; Grenouillet, Frédéric; Millon, Laurence; Vuitton, Dominique Angèle; Damy, Sylvie

2014-01-01

Alveolar echinococcosis (AE) is an endemic zoonosis in France due to the cestode Echinococcus multilocularis. The French National Reference Centre for Alveolar Echinococcosis (CNR-EA), connected to the FrancEchino network, is responsible for recording all AE cases diagnosed in France. Administrative, epidemiological and medical information on the French AE cases may currently be considered exhaustive only on the diagnosis time. To constitute a reference data set, an information system (IS) was developed thanks to a relational database management system (MySQL language). The current data set will evolve towards a dynamic surveillance system, including follow-up data (e.g. imaging, serology) and will be connected to environmental and parasitological data relative to E. multilocularis to better understand the pathogen transmission pathway. A particularly important goal is the possible interoperability of the IS with similar European and other databases abroad; this new IS could play a supporting role in the creation of new AE registries. © A. Charbonnier et al., published by EDP Sciences, 2014.

Evaluation of modal pushover-based scaling of one component of ground motion: Tall buildings

USGS Publications Warehouse

Kalkan, Erol; Chopra, Anil K.

2012-01-01

Nonlinear response history analysis (RHA) is now increasingly used for performance-based seismic design of tall buildings. Required for nonlinear RHAs is a set of ground motions selected and scaled appropriately so that analysis results would be accurate (unbiased) and efficient (having relatively small dispersion). This paper evaluates accuracy and efficiency of recently developed modal pushover–based scaling (MPS) method to scale ground motions for tall buildings. The procedure presented explicitly considers structural strength and is based on the standard intensity measure (IM) of spectral acceleration in a form convenient for evaluating existing structures or proposed designs for new structures. Based on results presented for two actual buildings (19 and 52 stories, respectively), it is demonstrated that the MPS procedure provided a highly accurate estimate of the engineering demand parameters (EDPs), accompanied by significantly reduced record-to-record variability of the responses. In addition, the MPS procedure is shown to be superior to the scaling procedure specified in the ASCE/SEI 7-05 document.

Color M-mode Doppler flow propagation velocity is a preload insensitive index of left ventricular relaxation: animal and human validation.

PubMed

Garcia, M J; Smedira, N G; Greenberg, N L; Main, M; Firstenberg, M S; Odabashian, J; Thomas, J D

2000-01-01

To determine the effect of preload in color M-mode Doppler flow propagation velocity (v(p)). The interpretation of Doppler filling patterns is limited by confounding effects of left ventricular (LV) relaxation and preload. Color M-mode v(p) has been proposed as a new index of LV relaxation. We studied four dogs before and during inferior caval (IVC) occlusion at five different inotropic stages and 14 patients before and during partial cardiopulmonary bypass. Left ventricular (LV) end-diastolic volumes (LV-EDV), the time constant of isovolumic relaxation (tau), left atrial (LA) pre-A and LV end-diastolic pressures (LV-EDP) were measured. Peak velocity during early filling (E) and v(p) were extracted by digital analysis of color M-mode Doppler images. In both animals and humans, LV-EDV and LV-EDP decreased significantly from baseline to IVC occlusion (both p < 0.001). Peak early filling (E) velocity decreased in animals from 56 +/- 21 to 42 +/- 17 cm/s (p < 0.001) without change in v(p) (from 35 +/- 15 to 35 +/- 16, p = 0.99). Results were similar in humans (from 69 +/- 15 to 53 +/- 22 cm/s, p < 0.001, and 37 +/- 12 to 34 +/- 16, p = 0.30). In both species, there was a strong correlation between LV relaxation (tau) and v(p) (r = 0.78, p < 0.001, r = 0.86, p < 0.001). Our results indicate that color M-mode Doppler v(p) is not affected by preload alterations and confirms that LV relaxation is its main physiologic determinant in both animals during varying lusitropic conditions and in humans with heart disease.

Color M-mode Doppler flow propagation velocity is a preload insensitive index of left ventricular relaxation: animal and human validation

NASA Technical Reports Server (NTRS)

Garcia, M. J.; Smedira, N. G.; Greenberg, N. L.; Main, M.; Firstenberg, M. S.; Odabashian, J.; Thomas, J. D.

2000-01-01

OBJECTIVES: To determine the effect of preload in color M-mode Doppler flow propagation velocity (v(p)). BACKGROUND: The interpretation of Doppler filling patterns is limited by confounding effects of left ventricular (LV) relaxation and preload. Color M-mode v(p) has been proposed as a new index of LV relaxation. METHODS: We studied four dogs before and during inferior caval (IVC) occlusion at five different inotropic stages and 14 patients before and during partial cardiopulmonary bypass. Left ventricular (LV) end-diastolic volumes (LV-EDV), the time constant of isovolumic relaxation (tau), left atrial (LA) pre-A and LV end-diastolic pressures (LV-EDP) were measured. Peak velocity during early filling (E) and v(p) were extracted by digital analysis of color M-mode Doppler images. RESULTS: In both animals and humans, LV-EDV and LV-EDP decreased significantly from baseline to IVC occlusion (both p < 0.001). Peak early filling (E) velocity decreased in animals from 56 +/- 21 to 42 +/- 17 cm/s (p < 0.001) without change in v(p) (from 35 +/- 15 to 35 +/- 16, p = 0.99). Results were similar in humans (from 69 +/- 15 to 53 +/- 22 cm/s, p < 0.001, and 37 +/- 12 to 34 +/- 16, p = 0.30). In both species, there was a strong correlation between LV relaxation (tau) and v(p) (r = 0.78, p < 0.001, r = 0.86, p < 0.001). CONCLUSIONS: Our results indicate that color M-mode Doppler v(p) is not affected by preload alterations and confirms that LV relaxation is its main physiologic determinant in both animals during varying lusitropic conditions and in humans with heart disease.

Impact of Pre-Stage II Hemodynamics and Pulmonary Artery Anatomy on 12-Month Outcome in the Single Ventricle Reconstruction Trial

PubMed Central

Aiyagari, Ranjit; Rhodes, John F.; Shrader, Peter; Radtke, Wolfgang A.; Bandisode, Varsha M.; Bergersen, Lisa; Gillespie, Matthew J.; Gray, Robert G.; Guey, Lin T.; Hill, Kevin D.; Hirsch, Russel; Kim, Dennis W.; Lee, Kyong-Jin; Pelech, Andrew N.; Ringewald, Jeremy; Takao, Cheryl; Vincent, Julie A.; Ohye, Richard G.

2014-01-01

Objective To compare interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for Single Ventricle Reconstruction (SVR) trial. Background The SVR trial, which randomized subjects to modified Blalock-Taussig shunt (MBTS) or right ventricle-to-pulmonary artery shunt (RVPAS) for the Norwood procedure, demonstrated RVPAS was associated with smaller pulmonary artery diameter, but superior 12-month transplant-free survival. Methods We analyzed pre-stage II catheterization data for SVR trial subjects. Hemodynamic variables and shunt and pulmonary angiography were compared between shunt types; their association with 12-month transplant-free survival was also evaluated. Results Of 549 randomized subjects, 389 underwent pre-stage II catheterization. Smaller size, lower aortic and superior vena cava saturation, and higher ventricular end-diastolic pressure (EDP) were associated with worse 12-month transplant-free survival. MBTS subjects had lower coronary perfusion pressure (27mmHg vs. 32mmHg, P<0.001) and higher Qp:Qs ratio (1.1 vs. 1.0, P=0.009). Higher Qp:Qs ratio increased the risk of death or transplant only in the RVPAS group (P=0.01). MBTS subjects had fewer shunt (14% vs. 28%, P=0.004) and severe left pulmonary artery stenoses (0.7% vs. 9.2%, P=0.003), larger mid-main branch pulmonary artery diameters and higher Nakata index (164 vs. 134, P<0.001). Conclusions Compared with RVPAS subjects, MBTS subjects had more hemodynamic abnormalities related to shunt physiology, while RVPAS subjects had more shunt or pulmonary obstruction of a severe degree, and inferior pulmonary artery growth at pre-stage II catheterization. Lower BSA, higher ventricular EDP, and lower SVC saturation were associated with worse 12-month transplant-free survival. PMID:24332668

Cyanobacterial carbon metabolism: Fluxome plasticity and oxygen dependence: Cyanobacterial Carbon Metabolism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wan, Ni; DeLorenzo, Drew M.; He, Lian

Synechocystis sp. strain PCC 6803 has been widely used as a photo-biorefinery chassis. Based on its genome annotation, this species contains a complete TCA cycle, an Embden-Meyerhof-Parnas pathway (EMPP), an oxidative pentose phosphate pathway (OPPP), and an Entner–Doudoroff pathway (EDP). To evaluate how Synechocystis 6803 catabolizes glucose under heterotrophic conditions, we performed 13C metabolic flux analysis, metabolite pool size analysis, gene knockouts, and heterologous expressions. The results revealed a cyclic mode of flux through the OPPP. Small, but non-zero, fluxes were observed through the TCA cycle and the malic shunt. Independent knockouts of 6-phosphogluconate dehydrogenase (gnd) and malic enzyme (me)more » corroborated these results, as neither mutant could grow under dark heterotrophic conditions. Our data also indicate that Synechocystis 6803 metabolism relies upon oxidative phosphorylation to generate ATP from NADPH under dark or insufficient light conditions. The pool sizes of intermediates in the TCA cycle, particularly acetyl-CoA, were found to be several fold lower in Synechocystis 6803 (compared to E. coli metabolite pool sizes), while its sugar phosphate intermediates were several-fold higher. Moreover, negligible flux was detected through the native, or heterologous, EDP in the wild type or Δgnd strains under heterotrophic conditions. Comparing photoautotrophic, photomixotrophic, and heterotrophic conditions, the Calvin cycle, OPPP, and EMPP in Synechocystis 6803 possess the ability to regulate their fluxes under various growth conditions (plastic), whereas its TCA cycle always maintains at low levels (rigid). This work also demonstrates how genetic profiles do not always reflect actual metabolic flux through native or heterologous pathways. Biotechnol. Bioeng. 2017;114: 1593–1602. © 2017 Wiley Periodicals, Inc.« less

[Imaging of temporo-mandibular disorders].

PubMed

Felizardo, Rufino; Foucart, Jean-Michel; Pizelle, Christophe

2012-03-01

Dominated for years by standard films (tomographic mouth open and mouth closed X-rays, MRI) radiographs of the TMJ have progressively lost their usefulness to diagnosticians who have progressively increased their reliance on well codified clinical examinations, which suffice in a great majority of cases.The indications for and diagnostic worth of radiological studies and the impact they have on the management of TMJ disorders are today quite low especially when the high cost of procedures like MRI, computerized tomography, and CBCT is taken into account. In this article we discuss the various maladies that dentists might encounter and the situations in which radiological examinations are still indicated. © EDP Sciences, SFODF, 2012.

Anti-infective activity of apolipoprotein domain derived peptides in vitro: identification of novel antimicrobial peptides related to apolipoprotein B with anti-HIV activity

PubMed Central

2010-01-01

Background Previous reports have shown that peptides derived from the apolipoprotein E receptor binding region and the amphipathic α-helical domains of apolipoprotein AI have broad anti-infective activity and antiviral activity respectively. Lipoproteins and viruses share a similar cell biological niche, being of overlapping size and displaying similar interactions with mammalian cells and receptors, which may have led to other antiviral sequences arising within apolipoproteins, in addition to those previously reported. We therefore designed a series of peptides based around either apolipoprotein receptor binding regions, or amphipathic α-helical domains, and tested these for antiviral and antibacterial activity. Results Of the nineteen new peptides tested, seven showed some anti-infective activity, with two of these being derived from two apolipoproteins not previously used to derive anti-infective sequences. Apolipoprotein J (151-170) - based on a predicted amphipathic alpha-helical domain from apolipoprotein J - had measurable anti-HSV1 activity, as did apolipoprotein B (3359-3367) dp (apoBdp), the latter being derived from the LDL receptor binding domain B of apolipoprotein B. The more active peptide - apoBdp - showed similarity to the previously reported apoE derived anti-infective peptide, and further modification of the apoBdp sequence to align the charge distribution more closely to that of apoEdp or to introduce aromatic residues resulted in increased breadth and potency of activity. The most active peptide of this type showed similar potent anti-HIV activity, comparable to that we previously reported for the apoE derived peptide apoEdpL-W. Conclusions These data suggest that further antimicrobial peptides may be obtained using human apolipoprotein sequences, selecting regions with either amphipathic α-helical structure, or those linked to receptor-binding regions. The finding that an amphipathic α-helical region of apolipoprotein J has antiviral activity comparable with that for the previously reported apolipoprotein AI derived peptide 18A, suggests that full-length apolipoprotein J may also have such activity, as has been reported for full-length apolipoprotein AI. Although the strength of the anti-infective activity of the sequences identified was limited, this could be increased substantially by developing related mutant peptides. Indeed the apolipoprotein B-derived peptide mutants uncovered by the present study may have utility as HIV therapeutics or microbicides. PMID:20298574

[Limiting factors in the class III camouflage treatment: a potential protocol].

PubMed

Chaques Asensi, José

2016-06-01

The Class III skeletal malocclusion has been traditionally treated with a combined approach of orthodontics and orthognathic surgery or with a strategy of orthodontic camouflage. Some severe cases can be identified as ideal candidates for a surgical treatment whereas some others can be handled with orthodontics alone, with a reasonable expectation of an acceptable result. However, the problem remains for the borderline patient. In fact, limited information is available in the literature regarding the identification of the factors that can help in establishing the limits for one treatment modality or the other. Furthermore, the quantification of some of these factors, for practical purposes, is practically missing or very seldom suggested. Therefore, the decision making process remains a subjective reflection based on the "good clinical sense" of the orthodontist or just reduced to an "educated guess". In order to add some information, hopefully useful in deciding the most suitable treatment option for the individual patient, we propose a clinical protocol based on four different factors. Namely: the skeletal discrepancy, the occlusal discrepancy, the periodontal condition and facial aesthetics. For each one of these factors several parameters will be evaluated and, for some of them, an attempt to provide some reference numerical values will be made. Finally, clinical examples will be presented to illustrate the concepts discussed and the treatment alternatives, final treatment plan and treatment outcome will be analyzed for each one of them. © EDP Sciences, SFODF, 2016.

External control of the Drosophila melanogaster egg to imago development period by specific combinations of 3D low-frequency electric and magnetic fields.

PubMed

Makarov, Vladimir I; Khmelinskii, Igor

2016-01-01

We report that the duration of the egg-to-imago development period of the Drosophila melanogaster, and the imago longevity, are both controllable by combinations of external 3-dimensional (3D) low-frequency electric and magnetic fields (LFEMFs). Both these periods may be reduced or increased by applying an appropriate configuration of external 3D LFEMFs. We report that the longevity of D. melanogaster imagoes correlates with the duration of the egg-to-imago development period of the respective eggs. We infer that metabolic processes in both eggs and imago are either accelerated (resulting in reduced time periods) or slowed down (resulting in increased time periods). We propose that external 3D LFEMFs induce electric currents in live systems as well as mechanical vibrations on sub-cell, whole-cell and cell-group levels. These external fields induce media polarization due to ionic motion and orientation of electric dipoles that could moderate the observed effects. We found that the longevity of D. melanogaster imagoes is affected by action of 3D LFEMFs on the respective eggs in the embryonic development period (EDP). We interpret this effect as resulting from changes in the regulation mechanism of metabolic processes in D. melanogaster eggs, inherited by the resulting imagoes. We also tested separate effects of either 3D electric or 3D magnetic fields, which were significantly weaker.

The CINMa index: assessing the potential impact of GM crop management across a heterogeneous landscape.

PubMed

Collier, Marcus J; Mullins, Ewen

2010-01-01

While significant progress has been made on the modification of crops for the benefit of producers, the same cannot be said in regards to eliciting the potential impact that these crops may have on the wider landscape and the diversity of life therein. Management impacts can create difficulties when making policy, regulation and licensing decisions in those countries where agriculture has a significant social and ecological position in the landscape. To begin to gauge the potential impacts of the management of a selection of GM crops on an agricultural landscape, four key biodiversity stressors (Chemicals, Introgression, Nutrients and Management: CINMa) were identified and a grading system developed using published data. Upon application to five selected GM crops in a case study area, CINMa identifies areas in the wider landscape where biodiversity is likely to be negatively or positively impacted, as well as agricultural zones which may benefit from the land use change associated with the management of GM crops and their associated post market environmental monitoring. © ISBR, EDP Sciences, 2011.

Distribution and abundance of hematophagous flies (Glossinidae, Stomoxys, and Tabanidae) in two national parks of Gabon.

PubMed

Bitome Essono, Paul Yannick; Dechaume-Moncharmont, François-Xavier; Mavoungou, Jacques; Obiang Mba, Régis; Duvallet, Gérard; Bretagnolle, François

2015-01-01

In order to minimize risks of pathogen transmission with the development of ecotourism in Gabon, a seasonal inventory has been performed in five contrasted biotopes in Ivindo (INP) and Moukalaba-Doudou (MDNP) National Parks. A total of 10,033 hematophagous flies were captured. The Glossinidae, with six different species identified, was the most abundant group and constitutes about 60% of the captured flies compared to the Stomoxys (6 species also identified) and Tabanidae with 28% and 12%, respectively. The Glossinidae showed a higher rate of capture in primary forest and in research camps. In INP, the Stomoxys showed a higher rate of capture in secondary forest and at village borders, whereas in MDNP the Stomoxys were captured more in the savannah area. Thus, each fly group seemed to reach maximum abundance in different habitats. The Glossinidae were more abundant in primary forest and near research camps while Stomoxys were more abundant in secondary forest and savannah. The Tabanidae did not show a clear habitat preference. © P.Y. Bitome Essono et al., published by EDP Sciences, 2015.

Concentrated energy addition for active drag reduction in hypersonic flow regime

NASA Astrophysics Data System (ADS)

Ashwin Ganesh, M.; John, Bibin

2018-01-01

Numerical optimization of hypersonic drag reduction technique based on concentrated energy addition is presented in this study. A reduction in wave drag is realized through concentrated energy addition in the hypersonic flowfield upstream of the blunt body. For the exhaustive optimization presented in this study, an in-house high precision inviscid flow solver has been developed. Studies focused on the identification of "optimum energy addition location" have revealed the existence of multiple minimum drag points. The wave drag coefficient is observed to drop from 0.85 to 0.45 when 50 Watts of energy is added to an energy bubble of 1 mm radius located at 74.7 mm upstream of the stagnation point. A direct proportionality has been identified between energy bubble size and wave drag coefficient. Dependence of drag coefficient on the upstream added energy magnitude is also revealed. Of the observed multiple minimum drag points, the energy deposition point (EDP) that offers minimum wave drag just after a sharp drop in drag is proposed as the most optimum energy addition location.

New preparations of the elemental diet and the clinical application.

PubMed

Ogoshi, S; Sato, H

1981-01-01

In 1978, we designed a new elemental diet, ED-AC, which modified after Vivonex-HN with the co-operation of Ajinomoto Co., Japan and Morton-Norwich Co., U.S.A.. ED-AC is now being used widely in Japan for enteral hyper-alimentation, even in case of pediatric surgery. We have new prepared another elemental diet, this time for infants, ED-P (pediatric). The ratio of amino acids in both ED was determined according the proposal of Professor Goro Inoue, Department of Nutrition, Tokushima University. The application of ED, particularly for surgical patients, has been most effective. the use of this diet for enteral hyperalimentation should find a wide application in surgical and medical practice.

[Treatment goals in FACE philosophy].

PubMed

Martin, Domingo; Maté, Amaia; Zabalegui, Paula; Valenzuela, Jaime

2017-03-01

The FACE philosophy is characterized by clearly defined treatment goals: facial esthetics, dental esthetics, periodontal health, functional occlusion, neuromuscular mechanism and joint function. The purpose is to establish ideal occlusion with good facial esthetics and an orthopedic stable joint position. The authors present all the concepts of FACE philosophy and illustrate them through one case report. Taking into account all the FACE philosophy concepts increases diagnostic ability and improves the quality and stability of treatment outcomes. The goal of this philosophy is to harmonize the facial profile, tooth alignment, periodontium, functional occlusion, neuromuscular mechanism and joint function. The evaluation and treatment approach to vertical problems are unique to the philosophy. © EDP Sciences, SFODF, 2017.

Evidence for robots.

PubMed

Shenoy, Ravikiran; Nathwani, Dinesh

2017-01-01

Robots have been successfully used in commercial industry and have enabled humans to perform tasks which are repetitive, dangerous and requiring extreme force. Their role has evolved and now includes many aspects of surgery to improve safety and precision. Orthopaedic surgery is largely performed on bones which are rigid immobile structures which can easily be performed by robots with great precision. Robots have been designed for use in orthopaedic surgery including joint arthroplasty and spine surgery. Experimental studies have been published evaluating the role of robots in arthroscopy and trauma surgery. In this article, we will review the incorporation of robots in orthopaedic surgery looking into the evidence in their use. © The Authors, published by EDP Sciences, 2017.

Inter-Population Movements of Steller Sea Lions in Alaska with Implications for Population Separation

PubMed Central

Jemison, Lauri A.; Pendleton, Grey W.; Fritz, Lowell W.; Hastings, Kelly K.; Maniscalco, John M.; Trites, Andrew W.; Gelatt, Tom S.

2013-01-01

Genetic studies and differing population trends support the separation of Steller sea lions (Eumetopias jubatus) into a western distinct population segment (WDPS) and an eastern DPS (EDPS) with the dividing line between populations at 144° W. Despite little exchange for thousands of years, the gap between the breeding ranges narrowed during the past 15–30 years with the formation of new rookeries near the DPS boundary. We analyzed >22,000 sightings of 4,172 sea lions branded as pups in each DPS from 2000–2010 to estimate probabilities of a sea lion born in one DPS being seen within the range of the other DPS (either ‘West’ or ‘East’). Males from both populations regularly traveled across the DPS boundary; probabilities were highest at ages 2–5 and for males born in Prince William Sound and southern Southeast Alaska. The probability of WDPS females being in the East at age 5 was 0.067 but 0 for EDPS females which rarely traveled to the West. Prince William Sound-born females had high probabilities of being in the East during breeding and non-breeding seasons. We present strong evidence that WDPS females have permanently emigrated to the East, reproducing at two ‘mixing zone’ rookeries. We documented breeding bulls that traveled >6,500 km round trip from their natal rookery in southern Alaska to the northern Bering Sea and central Aleutian Islands and back within one year. WDPS animals began moving East in the 1990s, following steep population declines in the central Gulf of Alaska. Results of our study, and others documenting high survival and rapid population growth in northern Southeast Alaska suggest that conditions in this mixing zone region have been optimal for sea lions. It is unclear whether eastward movement across the DPS boundary is due to less-optimal conditions in the West or a reflection of favorable conditions in the East. PMID:23940543

Inter-population movements of steller sea lions in Alaska with implications for population separation.

PubMed

Jemison, Lauri A; Pendleton, Grey W; Fritz, Lowell W; Hastings, Kelly K; Maniscalco, John M; Trites, Andrew W; Gelatt, Tom S

2013-01-01

Genetic studies and differing population trends support the separation of Steller sea lions (Eumetopias jubatus) into a western distinct population segment (WDPS) and an eastern DPS (EDPS) with the dividing line between populations at 144° W. Despite little exchange for thousands of years, the gap between the breeding ranges narrowed during the past 15-30 years with the formation of new rookeries near the DPS boundary. We analyzed >22,000 sightings of 4,172 sea lions branded as pups in each DPS from 2000-2010 to estimate probabilities of a sea lion born in one DPS being seen within the range of the other DPS (either 'West' or 'East'). Males from both populations regularly traveled across the DPS boundary; probabilities were highest at ages 2-5 and for males born in Prince William Sound and southern Southeast Alaska. The probability of WDPS females being in the East at age 5 was 0.067 but 0 for EDPS females which rarely traveled to the West. Prince William Sound-born females had high probabilities of being in the East during breeding and non-breeding seasons. We present strong evidence that WDPS females have permanently emigrated to the East, reproducing at two 'mixing zone' rookeries. We documented breeding bulls that traveled >6,500 km round trip from their natal rookery in southern Alaska to the northern Bering Sea and central Aleutian Islands and back within one year. WDPS animals began moving East in the 1990s, following steep population declines in the central Gulf of Alaska. Results of our study, and others documenting high survival and rapid population growth in northern Southeast Alaska suggest that conditions in this mixing zone region have been optimal for sea lions. It is unclear whether eastward movement across the DPS boundary is due to less-optimal conditions in the West or a reflection of favorable conditions in the East.

Early detection of radiation-induced heart disease using (99m)Tc-MIBI SPECT gated myocardial perfusion imaging in patients with oesophageal cancer during radiotherapy.

PubMed

Zhang, Peng; Hu, Xudong; Yue, Jinbo; Meng, Xue; Han, Dali; Sun, Xindong; Yang, Guoren; Wang, Shijiang; Wang, Xiaohui; Yu, Jinming

2015-05-01

The primary aim of this prospective study was to investigate the value of (99m)Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) gated myocardial perfusion imaging (GMPI) in the detection of radiation-induced heart disease (RIHD) as early as during radiotherapy (RT) for oesophageal cancer (EC). The second aim was to analyse the correlation between cardiac toxicity and the dose-volume factors. The (99m)Tc-MIBI SPECT GMPI was performed both pre-RT and during RT (40Gray). The results of the SPECT were quantitatively analysed with QGS/QPS software and read by two experienced nuclear medicine physicians. The correlation between the changes in the SPECT parameters and the RT dosimetric data was analysed. Eighteen patients with locally advanced EC were enrolled in the study. Compared with the baseline, the imaging during RT showed not only significant decreases in the wall motion (WM) (1/20 segments), wall thickening (WT) (2/20 segments), end-diastolic perfusion (EDP) (5/20 segments) and end-systolic perfusion (ESP) (8/20 segments) (p<0.05) but also a significant increase in the heart rate (74.63±7.79 vs 81.49±9.90, p=0.036). New myocardial perfusion defects were observed in 8 of the 18 patients. The V37-V40 was significantly higher (p<0.05) in the patients with the new perfusion defects during RT than in the patients who did not exhibit these defects. Radiotherapy for EC induces cardiac damage from an early stage. (99m)Tc-MIBI SPECT GMPI can detect the occurrence of cardiac impairment during RT. The WM, WT, EDP and ESP may be valuable as early indicators of RIHD. The percentage of the heart volume that receives a high dose is an important factor that is correlated with RIHD. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Localization of excitons by molecular layer formation in a polymer film

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chattopadhyay, S.; Datta, A.

2005-10-15

Spin coated films of atactic polystyrene of two different molecular weights have been studied with uv spectroscopy and x-ray reflectivity, the film thickness (d) varying from {approx}2R{sub g} to {approx}12R{sub g} where R{sub g} is the unperturbed radius of gyration of the polymer. uv extinction due to the pure electronic singlet {sup 1}A{sub 1g}{yields}{sup 1}E{sub 1u} is seen to increase with d{sup -1} for 4R{sub g}{<=}d{<=}12R{sub g} (region 1). This suggests excitonic interaction along d. The variation of total exciton energy (E) of the A{sub 1g}{yields}E{sub 1u} singlet with d in region 1 can be well explained by formation ofmore » linear J-aggregates of polystyrene molecules, in a lattice with spacing 'a' (in A) R{sub g}0 at d{approx_equal}4R{sub g}, where the exciton is still delocalized. Layering reduces the Hamaker constant (A{sub H}), deciding the cohesive force, between the layers and this reduction, {delta}A{sub H}, is found to be less than A{sub e} at d{>=}4R{sub g}, where iA{sub e}/({Dirac_h}/2{pi}) is the amplitude for exciton transfer between neighboring molecules in the excitonic lattice of region 1. On the other hand, {delta}A{sub H} in region 2 starts from a value larger than A{sub e}. This indicates that {delta}A{sub H} acts as a barrier between the layer, which localizes the exciton within the layers.« less

[White spot lesions and orthodontic treatment. Prevention and treatment].

PubMed

Morrier, Jean-Jacques

2014-09-01

Decalcification of the enamel surface adjacent to fixed orthodontic appliances, in the form of white spot lesions, is a common and frequent well-known side-effect of orthodontic treatment. Fixed appliances and the bonding materials increase the retention of biofilm and encourage the formation of white spot lesions. Management of these lesions begins with a good oral hygiene regime and needs to be associated with use of fluoride agents (fluoridated toothpaste, fluoride containing mouth rinse, gel, varnish, bonding materials, elastic ligature), CPP-ACP, antiseptics, LASER, tooth whitening, resin infiltration, micro-abrasion. The purpose of this review is to access the direct evidence regarding the prevention and management of white spot lesions during and after orthodontic treatment. © EDP Sciences, SFODF, 2014.

Final EDP Ti: sapphire amplifiers for ELI project

NASA Astrophysics Data System (ADS)

Chvykov, Vladimir; Kalashnikov, Mikhail; Osvay, Károly

2015-05-01

Recently several ultrahigh intensity Chirped Pulse Amplification (CPA) laser systems have reached petawatt output powers [1, 2] setting the next milestone at tens or even hundreds petawatts for the next three to ten years [3, 4]. These remarkable results were reached when laser amplifiers (opposite to Optical Parametric Amplification (OPA) [5]) were used as final ones and from them Ti:Sapphire crystals supposed to be the working horses as well in the future design of these laser systems. Nevertheless, the main limitation that arises on the path toward ultrahigh output power and intensity is the restriction on the pumping and extraction energy imposed by Transverse Amplified Spontaneous Emission (TASE) [6] and/or transverse parasitic generation (TPG) [7] within the large aperture of the disc-shape amplifier volume.

Seroprevalence and risk factors of Neospora caninum infection among domestic sheep in Henan province, central China.

PubMed

Wang, Shuai; Li, Lingjuan; Lu, Yi; Zhang, Haizhu; Xie, Qing; Zhang, Zhenchao

2018-01-01

This study aimed to determine the frequency of antibodies to Neospora caninum in domestic sheep raised in Henan province, central China. Serum samples from 779 domestic sheep were collected from March 2015 to May 2016, and antibodies to N. caninum were evaluated using an enzyme-linked immunosorbent assay (ELISA). The results showed an overall IgG positive rate of 7.32% (57/779). The risk factors significantly related to seropositivity to N. caninum in sheep were the age, the presence of dogs, and the rearing system. This is the first report of N. caninum infection and associated risk factors in domestic sheep in central China. © S. Wang et al., published by EDP Sciences, 2018.

Inorganic Bi/In thermal resist as a high-etch-ratio patterning layer for CF4/CHF3/O2 plasma etch

NASA Astrophysics Data System (ADS)

Tu, Yuqiang; Chapman, Glenn H.; Peng, Jun

2004-05-01

Bimetallic thin films containing indium and with low eutectic points, such as Bi/In, have been found to form highly sensitive thermal resists. They can be exposed by lasers with a wide range of wavelengths and be developed by diluted RCA2 solutions. The exposed bimetallic resist Bi/In can work as an etch masking layer for alkaline-based (KOH, TMAH and EDP) "wet" Si anisotropic etching. Current research shows that it can also act as a patterning and masking layer for Si and SiO2 plasma "dry" etch using CF4/CHF3. The profile of etched structures can be tuned by adding CHF3 and other gases such as Ar, and by changing the CF4/CHF3 ratio. Depending on the fluorocarbon plasma etching recipe the etch rate of laser exposed Bi/In can be as low as 0.1nm/min, 500 times lower than organic photoresists. O2 plasma ashing has little etching effect on exposed Bi/In, indicating that laser exposure is an oxidation process. Experiment result shows that single metal Indium film and bilayer Sn/In exhibit thermal resist characteristics but at higher exposure levels. They can be developed in diluted RCA2 solution and used as etch mask layers for Si anisotropic etch and plasma etch.

Probable hepatic capillariosis and hydatidosis in an adolescent from the late Roman period buried in Amiens (France).

PubMed

Mowlavi, Gholamreza; Kacki, Sacha; Dupouy-Camet, Jean; Mobedi, Iraj; Makki, Mahsasadat; Harandi, Majid Fasihi; Naddaf, Saied Reza

2014-01-01

Two calcified objects recovered from a 3rd to 4th-century grave of an adolescent in Amiens (Northern France) were identified as probable hydatid cysts. By using thin-section petrographic techniques, probable Calodium hepaticum (syn. Capillaria hepatica) eggs were identified in the wall of the cysts. Human hepatic capillariosis has not been reported from archaeological material so far, but could be expected given the poor level of environmental hygiene prevalent in this period. Identification of tissue-dwelling parasites such as C. hepaticum in archaeological remains is particularly dependent on preservation conditions and taphonomic changes and should be interpreted with caution due to morphological similarities with Trichuris sp. eggs. © G. Mowlavi et al., published by EDP Sciences, 2014.

Redescription of Clinostomum phalacrocoracis metacercariae (Digenea: Clinostomidae) in cichlids from Lake Kinneret, Israel.

PubMed

Caffara, Monica; Davidovich, Nadav; Falk, Rama; Smirnov, Margarita; Ofek, Tamir; Cummings, David; Gustinelli, Andrea; Fioravanti, Maria L

2014-01-01

Clinostomidae are digeneans characterized by a complex taxonomic history, continuously under revision based on both morphological and molecular analysis. Among the 14 species considered valid so far Clinostomum phalacrocoracis has been well described only at the adult stage, whereas the morphology of the metacercarial stage has been reported only once. During a parasitological survey carried out on 262 wild cichlids sampled from Lake Kinneret (Israel) metacercariae referable to C. phalacrocoracis were found in 18 fingerlings. In this study, we report this clinostomid species for the first time in wild fish from Israel describing the metacercarial stage of Clinostomum phalacrocoracis, coupling its morphological description with molecular analysis carried out on ITS rDNA and COI mtDNA sequences. © M. Caffara et al., published by EDP Sciences, 2014.

Immunological aspects of Giardia infections.

PubMed

Heyworth, Martin F

2014-01-01

Immunodeficiency, particularly antibody deficiency, predisposes to increased intensity and persistence of Giardia infections. Giardia-infected immunocompetent hosts produce serum and intestinal antibodies against Giardia trophozoites. The number of Giardia muris trophozoites, in mice with G. muris infection, is reduced by intra-duodenal administration of anti-G. muris antibody. Giardia intestinalis antigens that are recognised by human anti-trophozoite antibodies include variable (variant-specific) and invariant proteins. Nitric oxide (NO) appears to contribute to host clearance of Giardia trophozoites. Arginine is a precursor of NO and is metabolised by Giardia trophozoites, possibly reducing its availability for generation of NO by the host. Work with mice suggests that T lymphocytes and interleukin-6 (IL-6) contribute to clearance of Giardia infection via mechanisms independent of antibodies. © M.F. Heyworth, published by EDP Sciences, 2014.

Seroprevalence of Toxoplasma gondii infection and risk factors in domestic sheep in Henan province, central China.

PubMed

Zhang, Nian; Wang, Shuai; Wang, Dong; Li, Chaoying; Zhang, Zhenchao; Yao, Zhijun; Li, Tingting; Xie, Qing; Liu, Shiguo; Zhang, Haizhu

2016-01-01

Sheep are highly susceptible to infections with Toxoplasma gondii and play a major role in the transmission of toxoplasmosis to humans. In the present study, 779 serum samples from sheep were collected from Henan province, central China from March 2015 to May 2016, and antibodies to T. gondii were detected by modified agglutination test (MAT). The overall seroprevalence of T. gondii in sheep was 12.71% (99/779). The risk factors significantly associated with T. gondii seroprevalence were the geographical origin, age, presence of cats, and the rearing system. This is the first report of T. gondii infection in sheep in Henan province, central China, and of an association of seropositivity to T. gondii with risk factors. © N. Zhang et al., published by EDP Sciences, 2016.

Preface

NASA Astrophysics Data System (ADS)

Lexcellent, C.; Patoor, E.

2004-06-01

This international conference was held between the 18 and the 23th may 2003, in the "Villa Clythia" belonging to the CAES of the french "Comité National de la Recherche Scientifique CNRS" at Fréjus (France). The scope of this EMMC7 conference was about the use of smart materials which permits the conception of some adaptive systems for industrial applications. A special attention was devoted to active and passive controls of damping in structures. The use of this new class of materials (shape memory alloys, piezoelectric ceramics, TRIP steels, ferromagnetic shape memory alloys, ...) implies the development of numerical tools for computer assisted design process. Complexity of the involved material behaviour requires a deep understanding of strain mechanisms (martensitic phase transformation, reorientation process of domains), the use of accurate experimental techniques and advanced modelling approaches at various scale (micro, meso, macroscopic). In this purpose, it is necessary to use some coupled calculations connecting different fields of physics such as thermal, electromagnetism, electricity and mechanics of materials ones. The conference topic gave the opportunity of fruitful discussions between the mechanics of materials communauty and the specialists of damping or passive control. The scientific program contains nine oral sessions and one poster session. - Experimental characterization of the shape memory alloys thermomechanical behavior (two sessions) - Modeling of the shape memory alloy thermomechanical behavior (two sessions) - Ferromagnetic shape memory alloys behavior (one session) - Piezoelectric ceramics behavior (one session) - Transformation induced plasticity steel behavior (one session) - Hybrid structures including smart materials as sensor or actuator (one session) - Adaptive structure for vibration control (one session) - Poster session. The conference programm contains 50 lectures. 57 scientists were present and come from 14 different countries: 20 from France, 7 from Germany, 6 from Italy, 4 from Russia, 4 from Finland and 5 from USA ... This scientific programm allows all the participants interesting exchanges on "the state of art" about smart materials and adaptive systems. In the aim of its publication in the Proceedings of the EMMC7 Conference (EDP Sciences "Journal de Physique IV") each paper was expertised by two reviewers belonging to the International Scientific Committee and also other specialists. On that occasion, we will thank them for their very important contribution of the scientific level quality of the Proceedings. We will also thank: the sponsors of the Conference: Délégation Générale aux Armements (DGA), le Ministère de la Recherche, l'Université de Metz, l'ENSAM, le CNRS, l'Association Française de Mécanique et l'Institut des Microtechniques de Franche-Comté, the members of the organizing committee, the MECAMAT committee for trusting us, EDP Sciences for the Proceedings, The "Villa Clythia" team for his nice help in the material organization, ... and all the participants. The Co-chairmen Christian LEXCELLENT et Étienne PATOOR

[How to manage with rigour but flexibility an orthodontic practice].

PubMed

Binhas, Edmond; Binhas, Corinne

2017-03-01

An orthodontic office owner must understand the context and then combine logic, emotion, intuition and common sense. The productivity approach is no longer acceptable. It is necessary to combine rigour, flexibility and pragmatism. The obsessive perfectionism is ineffective. In fact, there are four ways to demonstrate a flexible determination: persevere when appropriate, win the support of your entourage, back on some decisions, appeal to the collective will. Another needed feature is to have the flexibility to change its own habits and change the ones of others. Some practical examples based on the five available resources (time, money, people, training and equipment) illustrate the concepts discussed. Both qualities are necessary for the orthodontic business manager today: strong leadership and flexibility. The best attitude lies in the combination of these two seemingly contradictory requirements. © EDP Sciences, SFODF, 2017.

Balantidium grimi n. sp. (Ciliophora, Litostomatea), a new species inhabiting the rectum of the frog Quasipaa spinosa from Lishui, China.

PubMed

Zhao, Weishan; Li, Can; Zhang, Dong; Wang, Runqiu; Zheng, Yingzhen; Zou, Hong; Li, Wenxiang; Wu, Shangong; Wang, Guitang; Li, Ming

2018-01-01

Balantidium grimi n. sp. is described from the rectum of the frog Quasipaa spinosa (Amphibia, Dicroglossidae) from Lishui, Zhejiang Province, China. The new species is described by both light microscopy (LM) and scanning electron microscopy (SEM), and a molecular phylogenetic analysis is also presented. This species has unique morphological features in that the body shape is somewhat flattened and the vestibulum is "V"-shaped, occupying nearly 3/8 to 4/7 of the body length. Only one contractile vacuole, situated at the posterior body, was observed. The phylogenetic analysis based on SSU-rDNA indicates that B. grimi groups together with B. duodeni and B. entozoon. In addition, the genus Balantidium is clearly polyphyletic. © W. Zhao et al., published by EDP Sciences, 2018.

Fatal Toxoplasma gondii infection in the giant panda.

PubMed

Ma, Hongyu; Wang, Zedong; Wang, Chengdong; Li, Caiwu; Wei, Feng; Liu, Quan

2015-01-01

Toxoplasma gondii can infect nearly all warm-blooded animals. We report an acute fatal T. gondii infection in the endangered giant panda (Ailuropoda melanoleuca) in a zoo in China, characterized by acute gastroenteritis and respiratory symptoms. T. gondii infection was confirmed by immunological and molecular methods. Multilocus nested PCR-RFLP revealed clonal type I at the SAG1 and c29-2 loci, clonal type II at the SAG2, BTUB, GRA6, c22-8, and L358 loci, and clonal type III at the alternative SAG2 and SAG3 loci, thus, a potential new genotype of T. gondii in the giant panda. Other possible pathogens were not detected. To our knowledge, this is the first report of clinical toxoplasmosis in a giant panda. © H. Ma et al., published by EDP Sciences, 2015.

Lossless medical image compression using geometry-adaptive partitioning and least square-based prediction.

PubMed

Song, Xiaoying; Huang, Qijun; Chang, Sheng; He, Jin; Wang, Hao

2018-06-01

To improve the compression rates for lossless compression of medical images, an efficient algorithm, based on irregular segmentation and region-based prediction, is proposed in this paper. Considering that the first step of a region-based compression algorithm is segmentation, this paper proposes a hybrid method by combining geometry-adaptive partitioning and quadtree partitioning to achieve adaptive irregular segmentation for medical images. Then, least square (LS)-based predictors are adaptively designed for each region (regular subblock or irregular subregion). The proposed adaptive algorithm not only exploits spatial correlation between pixels but it utilizes local structure similarity, resulting in efficient compression performance. Experimental results show that the average compression performance of the proposed algorithm is 10.48, 4.86, 3.58, and 0.10% better than that of JPEG 2000, CALIC, EDP, and JPEG-LS, respectively. Graphical abstract ᅟ.

A pulse-shape discrimination method for improving Gamma-ray spectrometry based on a new digital shaping filter

NASA Astrophysics Data System (ADS)

Qin, Zhang-jian; Chen, Chuan; Luo, Jun-song; Xie, Xing-hong; Ge, Liang-quan; Wu, Qi-fan

2018-04-01

It is a usual practice for improving spectrum quality by the mean of designing a good shaping filter to improve signal-noise ratio in development of nuclear spectroscopy. Another method is proposed in the paper based on discriminating pulse-shape and discarding the bad pulse whose shape is distorted as a result of abnormal noise, unusual ballistic deficit or bad pulse pile-up. An Exponentially Decaying Pulse (EDP) generated in nuclear particle detectors can be transformed into a Mexican Hat Wavelet Pulse (MHWP) and the derivation process of the transform is given. After the transform is performed, the baseline drift is removed in the new MHWP. Moreover, the MHWP-shape can be discriminated with the three parameters: the time difference between the two minima of the MHWP, and the two ratios which are from the amplitude of the two minima respectively divided by the amplitude of the maximum in the MHWP. A new type of nuclear spectroscopy was implemented based on the new digital shaping filter and the Gamma-ray spectra were acquired with a variety of pulse-shape discrimination levels. It had manifested that the energy resolution and the peak-Compton ratio were both improved after the pulse-shape discrimination method was used.

Defining an additivity framework for mixture research in inducible whole-cell biosensors

NASA Astrophysics Data System (ADS)

Martin-Betancor, K.; Ritz, C.; Fernández-Piñas, F.; Leganés, F.; Rodea-Palomares, I.

2015-11-01

A novel additivity framework for mixture effect modelling in the context of whole cell inducible biosensors has been mathematically developed and implemented in R. The proposed method is a multivariate extension of the effective dose (EDp) concept. Specifically, the extension accounts for differential maximal effects among analytes and response inhibition beyond the maximum permissive concentrations. This allows a multivariate extension of Loewe additivity, enabling direct application in a biphasic dose-response framework. The proposed additivity definition was validated, and its applicability illustrated by studying the response of the cyanobacterial biosensor Synechococcus elongatus PCC 7942 pBG2120 to binary mixtures of Zn, Cu, Cd, Ag, Co and Hg. The novel method allowed by the first time to model complete dose-response profiles of an inducible whole cell biosensor to mixtures. In addition, the approach also allowed identification and quantification of departures from additivity (interactions) among analytes. The biosensor was found to respond in a near additive way to heavy metal mixtures except when Hg, Co and Ag were present, in which case strong interactions occurred. The method is a useful contribution for the whole cell biosensors discipline and related areas allowing to perform appropriate assessment of mixture effects in non-monotonic dose-response frameworks

[Orthodontic Management of the Impacted Mandibular Second Molar Tooth].

PubMed

Mah, Michael; Takada, Kenji

2016-09-01

When the mandibular permanent second molar becomes impacted, it is identified as a malocclusion that needs treatment as it often leads to unwanted complications such as caries and periodontitis of the adjacent permanent first molar. Other less common complications include root resorption of the adjacent first molar root or continued root development to be in close proximity to the inferior dental alveolar nerve. This paper seeks to differentiate various levels of severity of impaction and review treatment options that are considered clinically available for the proper management of the impacted mandibular permanent second molar. Treatment options that will be discussed in this article include timing of second molar removal for replacement by the third molar, relief of impaction via second premolar removal, surgical repositioning and the combination of third molar removal, surgical exposure and orthodontic uprighting of the impacted tooth. Depending on the severity of the impaction, most impactions can be easily and predictably corrected with nickel titanium archwires or auxillary open coil springs or uprighting springs. Uncommonly, the mandibular permanent second molar can become severely impacted and in close proximity to the inferior dentoalveolar nerve. In these instances, the use of temporary anchorage devices such as microimplants has shown to be successful in uprighting the severely impacted mandibular permanent second molars. © EDP Sciences, SFODF, 2016.

Do developmental initiatives influence local attitudes toward conservation? A case study from the Kalakad-Mundanthurai Tiger Reserve, India.

PubMed

Arjunan, M; Holmes, Christopher; Puyravaud, Jean-Philippe; Davidar, Priya

2006-04-01

We evaluated the conservation attitudes of the local villagers living adjacent to the Kalakad-Mundanthurai Tiger Reserve in southern India 6 years after implementation of a World Bank funded eco-development project. We assessed attitudes towards three facets of conservation: the tiger, an emblematic species signifying India's commitment to wildlife conservation; the forest, a principle source of fuel-wood and other products; and the Forest Department, which manages the forest. More specifically we predicted that (i) attitudes would be an effective predictor of resource use interest in the forest and (ii) benefits obtained from the EDP would create more favorable attitudes towards conservation and the protected area employees. Twelve villages located within 3 km from the reserve boundary were chosen and 2-3% of the households interviewed with regard to their attitudes towards these three facets of conservation, their household resource use patterns, wealth, sex, age and length of residency. We found significant associations between wealth, sex, age and both tiger and forest conservation. Providing benefits has not changed the underlying attitudes of the communities. The poorer sections of society, whether receiving benefits or not, tended to support tiger conservation because conserving wildlife did not affect their livelihood in any way, whereas both the rich and poor had misgivings about forest conservation due to dependency on forest products. We conclude that the eco-development project has not effectively addressed the most important of the local concerns.

Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins.

PubMed

Villalba, Juan J; Miller, James; Ungar, Eugene D; Landau, Serge Y; Glendinning, John

2014-01-01

Gastrointestinal helminths challenge ruminants in ways that reduce their fitness. In turn, ruminants have evolved physiological and behavioral adaptations that counteract this challenge. Ruminants display anorexia and avoidance behaviors, which tend to reduce the incidence of parasitism. In addition, ruminants appear to learn to self-medicate against gastrointestinal parasites by increasing consumption of plant secondary compounds with antiparasitic actions. This selective feeding improves health and fitness. Here, we review the evidence for self-medication in ruminants, propose a hypothesis to explain self-medicative behaviors (based on post-ingestive consequences), and discuss mechanisms (e.g., enhanced neophilia, social transmission) that may underlie the ontogeny and spread of self-medicative behaviors in social groups. A better understanding of the mechanisms that underlie and trigger self-medication in parasitized animals will help scientists devise innovative and more sustainable management strategies for improving ruminant health and well-being. © J.J. Villalba et al., published by EDP Sciences, 2014.

New insights into sub-ion scale turbulence in Earth's magnetosheath using MMS data

NASA Astrophysics Data System (ADS)

Breuillard, Hugo; Andriopoulou, Maria; Graham, Daniel; Le Contel, Olivier; Huang, Shiyong; Hadid, Lina; Sahraoui, Fouad; Alexandrova, Olga; Berthomier, Matthieu; Retino, Alessandro; Nakamura, Rumi; Baumjohann, Wolfgang

2017-04-01

On January 22nd 2016, MMS was located in Earth's magnetosheath and detected intense lion roars showing a secondary bandwidth. Detailed polarization analysis, using burst data from SCM and EDP instruments, and numerical simulation, using WHAMP, are performed in this study. They show that these mainly perpendicular fluctuations are highly nonlinear whistler wave packets, and that a high sampling rate is needed to pick up the peaks of the signal. As a result, their amplitude might have been underestimated in previous missions such as Cluster, which can have a significant impact on electron dynamics. Using FPI burst data, we show that electron velocity distribution functions exhibit a gyrophase-bunched signature in the presence of these lion roars. The analysis of magnetic and density fluctuations, inferred from spacecraft potential, also show the highly-compressible nature of turbulence up to electron scales.

First record of the invasive Asian fish tapeworm Bothriocephalus acheilognathi in Honduras, Central America.

PubMed

Salgado-Maldonado, Guillermo; Matamoros, Wilfredo A; Kreiser, Brian R; Caspeta-Mandujano, Juan Manuel; Mendoza-Franco, Edgar F

2015-01-01

This paper provides the first report of the invasive Asian fish tapeworm, Bothriocephalus acheilognathi Yamaguti, 1934, in Honduras. The cestode was found in Profundulus portillorum (Cyprinodontiformes: Profundulidae), which represents a new host record, and which is a member of a genus faced with a variety of conservation challenges, now potentially complicated by the presence of this pathogenic cestode. Nearly complete sequence data from the ITS-1 5.8S and ITS-2 regions corroborate the determination based on morphological characteristics. Several species of carp were introduced to Honduras for aquaculture purposes in the early 1980s and the presence of the Asian fish tapeworm in Honduras may be related to these introductions. In addition, this report documents the currently known geographical distribution of this parasite in Central America, first recorded from Panamá and now from Honduras. © G. Salgado-Maldonado et al., published by EDP Sciences, 2015.

Micromachined mold-type double-gated metal field emitters

NASA Astrophysics Data System (ADS)

Lee, Yongjae; Kang, Seokho; Chun, Kukjin

1997-12-01

Electron field emitters with double gates were fabricated using micromachining technology and the effect of the electric potential of the focusing gate (or second gate) was experimentally evaluated. The molybdenum field emission tip was made by filling a cusplike mold formed when a conformal film was deposited on the hole-trench that had been patterned on stacked metals and dielectric layers. The hole-trench was patterned by electron beam lithography and reactive ion etching. Each field emitter has a 0960-1317/7/4/009/img1 diameter extraction gate (or first gate) and a 0960-1317/7/4/009/img2 diameter focusing gate (or second gate). To make a path for the emitted electrons, silicon bulk was etched anisotropically in KOH and EDP (ethylene-diamine pyrocatechol) solution successively. The I - V characteristics and anode current change due to the focusing gate potential were measured.

[Reciprocal relationships between orthodontics and periodontics in esthetic treatments].

PubMed

Monnet-Corti, Virginie; Barrin, Arnaud; Goubron, Cyril

2012-06-01

The objective of this article is to review various unsightly periodontal defects and the treatments that have previously been used to eliminate them in order to establish guidelines for future therapy. The inter-relationship between orthodontic and periodontal disciplines is well established and needs no defense here. Periodontal tissues change throughout life and the same is true for the smile. The periodontium is an essential component of the appearance of the face as well as the lips. These are dynamic esthetic criteria while the gingiva and the static character of the dentition also contribute to the character of an individual's smile. In order to conduct orthodontic therapy most effectively it is essential that orthodontists and periodontists utilize a coordinated approach. From the beginning, they must establish an etiological diagnosis of any esthetic defects that will insure that their joint therapy is conducted appropriately and at the proper moment. © EDP Sciences, SFODF, 2012.

[Can orthodontic treatment generate temporomandibular disorders and pain? A review].

PubMed

Gebeile-Chauty, Sarah; Robin, Olivier; Messaoudi, Yassine; Aknin, Jean-Jacques

2010-03-01

While considered for years to play the primary role in the etiology of temporo-mandibular joint disturbances (TMD), occlusal discrepancies are now considered to be just one causative factor among many. Recent studies, literature reviews or meta-analyses, and longitudinal studies with follow-up of children treated for many years all conclude that there is no risk of orthodontic treatment giving rise to episodes of temporo-mandibular disorders. The signs of TMD appearing during the course of orthodontic treatment should be considered in the context of the epidemiology of the disorder, which is characterized by a strong increase in its occurrence during adolescence. In conclusion, it should be stated that if orthodontic treatment can no longer be considered as one of the etiopathogenic factors in the TMD complex, there are no scientific arguments to justify the converse, that there are indications for orthodontic treatment whose sole goal would be the treatment of TMD. EDP Sciences, SFODF, 2010.

Constraint-Based Local Search for Constrained Optimum Paths Problems

NASA Astrophysics Data System (ADS)

Pham, Quang Dung; Deville, Yves; van Hentenryck, Pascal

Constrained Optimum Path (COP) problems arise in many real-life applications and are ubiquitous in communication networks. They have been traditionally approached by dedicated algorithms, which are often hard to extend with side constraints and to apply widely. This paper proposes a constraint-based local search (CBLS) framework for COP applications, bringing the compositionality, reuse, and extensibility at the core of CBLS and CP systems. The modeling contribution is the ability to express compositional models for various COP applications at a high level of abstraction, while cleanly separating the model and the search procedure. The main technical contribution is a connected neighborhood based on rooted spanning trees to find high-quality solutions to COP problems. The framework, implemented in COMET, is applied to Resource Constrained Shortest Path (RCSP) problems (with and without side constraints) and to the edge-disjoint paths problem (EDP). Computational results show the potential significance of the approach.

[The pendulis appliance: a palatal miniscrew supported molar distalization device].

PubMed

Nappée-Miévilly, Magali; Nappée, François-Joseph; Kerbrat, Jean-Baptiste; Goudot, Patrick

2014-09-01

The maxillary molar distalization is a valuable therapeutic option in some clinical cases. Its biomechanics is challenging and difficult to obtain. Historically, various devices have been described offering successful solutions to this problem such as the Hilgers Pendulum Appliance (1992) and variants linked to mini screws which recently have shown interesting clinical potential. This article presents a new Pendulum variant using a miniscrew, the "pendulis". It follows the original concept (titanium-molybdenum alloy distalization springs and polymethyl-methacrylate pellet) but dental support is replaced by a single palatal miniscrew (median adults, para-median in children) to which the device is fixed by means of a metal welded cap easily positioned and removable by the practitioner. This allows for better control of the oral hygiene and completely controlled extraoral activation. Fabrication steps are described and instruction of use is illustrated with clinical documentation. © EDP Sciences, SFODF, 2014.

[Normal and pathologic mandible development: practical deductions in maxillo-dento-facial orthopedics].

PubMed

Salagnac, Jean-Michel

2016-09-01

The mandible consists of different segments, each of which possess its own specific characteristics regarding emergence, ossification during growth and pathologies. Orthodontists need to be very familiar with these developmental anomalies if they are to avoid failure in their orthopedic or orthodontic treatments and in order to understand the reasons for the lack of success of "conventional" treatments. Each segment must develop correctly if the mandible is to achieve optimal development and occupy a normal position within the cranio-facial complex. The position of the mandible in the cranio-facial block is also conditioned by its attachment to the base of the skull. Combining a detailed semiologic study and a three-dimensional architectural and structural radiologic analysis of clinical cases, this article investigates the various anomalies affecting the mandibular segments and their impact on the craniofacial structure as a whole. An understanding of these anomalies and this analytical method can enable clinicians to perform early diagnosis, avoid undertaking orthopedic and orthodontic treatments which are likely to fail, understand the reasons for unsuccessful "conventional" treatments, provide an orthopedic-surgical guide and make it possible to inform patients correctly. Anomalies affecting the growth of the mandible and its position on the cranial base and their impact on cranio-facial skeletal balance are clearly revealed by structural and architectural analysis, which pinpoints the different clinical elements in skeletal Class II et III cases. In maxilla-dento-facial orthopedics when confronted with a pathology of mandibular origin, it is essential to carefully study the radiographs of each segment of the mandible, to seek out the minor forms of the anomalies and to calculate the position of the mandible on the cranial base relative to the neighboring structures; the skull, the cervical vertebrae and the maxilla. © EDP Sciences, SFODF, 2016.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mori, Koichiro, E-mail: kmori@iis.u-tokyo.ac.jp; Christodoulou, Aris, E-mail: aris.christodoulou@ucl.ac.uk

The purpose of this paper is to discuss conceptual requirements for a City Sustainability Index (CSI) and to review existing major sustainability indices/indicators in terms of the requirements. The following indices are reviewed: Ecological Footprint (EF), Environmental Sustainability Index (ESI), Dashboard of Sustainability (DS), Welfare Index, Genuine Progress Indicator (GPI), Index of Sustainable Economic Welfare, City Development Index, emergy/exergy, Human Development Index (HDI), Environmental Vulnerability Index (EVI), Environmental Policy Index (EPI), Living Planet Index (LPI), Environmentally-adjusted Domestic Product (EDP), Genuine Saving (GS), and some applications of composite indices or/and multivariate indicators to local or regional context as case studies. Themore » key conceptual requirements for an adequate CSI are: (i) to consider environmental, economic and social aspects (the triple bottom line of sustainability) from the viewpoint of strong sustainability; (ii) to capture external impacts (leakage effects) of city on other areas beyond the city boundaries particularly in terms of environmental aspects; (iii) to create indices/indicators originally for the purpose of assessing city sustainability; and (iv) to be able to assess world cities in both developed and developing countries using common axes of evaluation. Based on the review, we conclude that it is necessary to create a new CSI that enables us to assess and compare cities' sustainability performance in order to understand the global impact of cities on the environment and human life as compared with their economic contribution. In the future, the CSI will be able to provide local authorities with guidance toward sustainable paths. - Highlights: Black-Right-Pointing-Pointer We derive the four key requirements for a new City Sustainability Index (CSI) system. Black-Right-Pointing-Pointer First, the triple bottom line must be considered in terms of strong sustainability. Black-Right-Pointing-Pointer Second, environmental leakage effects beyond city boundaries should be captured. Black-Right-Pointing-Pointer Third, 'city sustainability' should be originally considered when CSI is created. Black-Right-Pointing-Pointer Fourth, cities in developed and developing countries can be evaluated without bias.« less

Anisotropic Reinforcement of Acute Anteroapical Infarcts Improves Pump Function

PubMed Central

Fomovsky, Gregory M.; Clark, Samantha A.; Parker, Katherine M.; Ailawadi, Gorav; Holmes, Jeffrey W.

2012-01-01

Background We hypothesize that a therapy that improves LV pump function early after infarction should decrease the need for compensation through sympathetic activation and dilation, thereby reducing the risk of developing heart failure. The mechanical properties of healing myocardial infarcts are an important determinant of left ventricular (LV) function, yet improving function by altering infarct properties has proven unexpectedly difficult. Using a computational model, we recently predicted that stiffening a large anterior infarct anisotropically (in only one direction) would improve LV function, while isotropic stiffening, the focus of previous studies and therapies, would not. The goal of this study was to test the novel strategy of anisotropic infarct reinforcement. Methods and Results We tested the effects of anisotropic infarct reinforcement in 10 open-chest dogs with large anteroapical infarcts that depressed LV pump function. We measured regional mechanics, LV volumes, and cardiac output at a range of preloads at Baseline, 45 minutes after coronary ligation (Ischemia), and 30 minutes later, following surgical reinforcement in the longitudinal direction (Anisotropic). Ischemia shifted the end-systolic pressure-volume relationship (ESPVR) and cardiac output curves rightward, decreasing cardiac output at matched end-diastolic pressure (EDP) by 44%. Anisotropic reinforcement significantly improved systolic function without impairing diastolic function, recovering half the deficit in overall LV function. Conclusions We conclude that anisotropic reinforcement is a promising new approach to improving LV function following a large myocardial infarction. PMID:22665716

Next Generation CTAS Tools

NASA Technical Reports Server (NTRS)

Erzberger, Heinz

2000-01-01

The FAA's Free Flight Phase 1 Office is in the process of deploying the current generation of CTAS tools, which are the Traffic Management Advisor (TMA) and the passive Final Approach Spacing Tool (pFAST), at selected centers and airports. Research at NASA is now focussed on extending the CTAS software and computer human interfaces to provide more advanced capabilities. The Multi-center TMA (McTMA) is designed to operate at airports where arrival flows originate from two or more centers whose boundaries are in close proximity to the TRACON boundary. McTMA will also include techniques for routing arrival flows away from congested airspace and around airspace reserved for arrivals into other hub airports. NASA is working with FAA and MITRE to build a prototype McTMA for the Philadelphia airport. The active Final Approach Spacing Tool (aFAST) provides speed and heading advisories to help controllers achieve accurate spacing between aircraft on final approach. These advisories will be integrated with those in the existing pFAST to provide a set of comprehensive advisories for controlling arrival traffic from the TRACON boundary to touchdown at complex, high-capacity airports. A research prototype of aFAST, designed for the Dallas-Fort Worth is in an advanced stage of development. The Expedite Departure Path (EDP) and Direct-To tools are designed to help controllers guide departing aircraft out of the TRACON airspace and to climb to cruise altitude along the most efficient routes.

[Condylar hyperplasia: qualitative and quantitative study of temporomandibular joints remodeling before and after condylectomy].

PubMed

Rojare, Camille; Wojcik, Thomas; Coussens, Camille; Ferri, Joël; Pertuzon, Bruno; Raoul, Gwénaël

2014-06-01

This retrospective study aimed to evaluate bone remodeling of temporo-mandibular joints (TMJ) using computed tomography (CT) before and after condylectomy for condylar hyperplasia. TMJ bone remodeling was studied by comparing the pre and postoperative CT scan of ten patients. Qualitative evaluation was performed by two-dimensional analysis. Three-dimensional analysis superimpositions were done after digital condylar units isolation. Condylar volume modifications were measured and compared on both sides. Lastly, before and after surgery, we studied the radio-clinic correlations. After surgery, all the operated condyles developed a new cortical bone. We noticed also a thickening of the glenoid fossa. Surgical condylectomy leaded to a 43.5% volume reduction on the operated side and 2.14% on the controlateral side. On the controlateral side, most of abnormalities seen preoperatively disappeared after surgery. For two patients, the condylar resection took away over 80% of the initial volume. For these patients, we observed major radiologic modifications on the controlateral TMJ associated with symptoms of dysfunction. These problems did not worsen their quality of life. Both TMJ presented with bone remodelling after condylectomy. In condylar hyperplasia, condylectomy provides orthopaedic results on dysmorphia and removal of the pathological prechondroblastic zone. In the future, an earlier detection of this pathology may help the surgeon to treat in childhood. This would limit surgical excision and would avoid important dysmorphia. © EDP Sciences, SFODF, 2014.

Host specificity and the structure of helminth parasite communities of fishes in a Neotropical river in Mexico.

PubMed

Salgado-Maldonado, Guillermo; Novelo-Turcotte, María Teresa; Caspeta-Mandujano, Juan Manuel; Vazquez-Hurtado, Gabriela; Quiroz-Martínez, Benjamin; Mercado-Silva, Norman; Favila, Mario

2016-01-01

In a tropical locality of Río La Antigua, Veracruz, Mexico, 11 fish species, represented by 244 individual fish from six freshwater fish families living sympatrically and synchronically, were examined for helminth parasites. A total of 36 taxa of helminths were recorded, 24 autogenic and 12 allogenic forms, including 6 monogeneans, 14 trematodes, 1 cestode, and 15 nematodes. Most helminth taxa were recovered for 10/11 of the component communities we analyzed. The results contribute empirical evidence that host specificity is an important force in the development of helminth communities of freshwater fishes. Each fish family has their own set of parasites, host species belonging to the same taxon share parasite species. High component community similarity among related host species was recorded, demonstrated by high prevalence and abundance, as well as dominance, of autogenic specialist species in each component community. Most autogenic helminth species are numerically and reproductively successful in relatively few host species. Autogenic helminths common in one host species are not common in others. Our findings give empirical support to the idea that low levels of sharing of parasites favor animal coexistence and high species richness, because large phylogenetic differences allow potentially competing animals to consume the same resources without being sensitive of another's parasites. © G. Salgado-Maldonado et al., published by EDP Sciences, 2016.

M4AST - A Tool for Asteroid Modelling

NASA Astrophysics Data System (ADS)

Birlan, Mirel; Popescu, Marcel; Irimiea, Lucian; Binzel, Richard

2016-10-01

M4AST (Modelling for asteroids) is an online tool devoted to the analysis and interpretation of reflection spectra of asteroids in the visible and near-infrared spectral intervals. It consists into a spectral database of individual objects and a set of routines for analysis which address scientific aspects such as: taxonomy, curve matching with laboratory spectra, space weathering models, and mineralogical diagnosis. Spectral data were obtained using groundbased facilities; part of these data are precompiled from the literature[1].The database is composed by permanent and temporary files. Each permanent file contains a header and two or three columns (wavelength, spectral reflectance, and the error on spectral reflectance). Temporary files can be uploaded anonymously, and are purged for the property of submitted data. The computing routines are organized in order to accomplish several scientific objectives: visualize spectra, compute the asteroid taxonomic class, compare an asteroid spectrum with similar spectra of meteorites, and computing mineralogical parameters. One facility of using the Virtual Observatory protocols was also developed.A new version of the service was released in June 2016. This new release of M4AST contains a database and facilities to model more than 6,000 spectra of asteroids. A new web-interface was designed. This development allows new functionalities into a user-friendly environment. A bridge system of access and exploiting the database SMASS-MIT (http://smass.mit.edu) allows the treatment and analysis of these data in the framework of M4AST environment.Reference:[1] M. Popescu, M. Birlan, and D.A. Nedelcu, "Modeling of asteroids: M4AST," Astronomy & Astrophysics 544, EDP Sciences, pp. A130, 2012.

Echinococcus metacestode: in search of viability markers.

PubMed

Gottstein, Bruno; Wang, Junhua; Blagosklonov, Oleg; Grenouillet, Frédéric; Millon, Laurence; Vuitton, Dominique A; Müller, Norbert

2014-01-01

Epidemiological studies have demonstrated that most humans infected with Echinococcus spp. exhibit resistance to disease. When infection leads to disease, the parasite is partially controlled by host immunity: in case of immunocompetence, the normal alveolar echinococcosis (AE) or cystic echinococcosis (CE) situation, the metacestode grows slowly, and first clinical signs appear years after infection; in case of impaired immunity (AIDS; other immunodeficiencies), uncontrolled proliferation of the metacestode leads to rapidly progressing disease. Assessing Echinococcus multilocularis viability in vivo following therapeutic interventions in AE patients may be of tremendous benefit when compared with the invasive procedures used to perform biopsies. Current options are F18-fluorodeoxyglucose-positron emission tomography (FDG-PET), which visualizes periparasitic inflammation due to the metabolic activity of the metacestode, and measurement of antibodies against recEm18, a viability-associated protein, that rapidly regresses upon metacestode inactivation. For Echinococcus granulosus, similar prognosis-associated follow-up parameters are still lacking but a few candidates may be listed. Other possible markers include functional and diffusion-weighted Magnetic Resonance Imaging (MRI), and measurement of products from the parasite (circulating antigens or DNA), and from the host (inflammation markers, cytokines, or chemokines). Even though some of them have been promising in pilot studies, none has been properly validated in an appropriate number of patients until now to be recommended for further use in clinical settings. There is therefore still a need to develop reliable tools for improved viability assessment to provide the sufficient information needed to reliably withdraw anti-parasite benzimidazole chemotherapy, and a basis for the development of new alternative therapeutic tools. © B. Gottstein et al., published by EDP Sciences, 2014.

Correlations between Energy and Displacement Demands for Performance-Based Seismic Engineering

NASA Astrophysics Data System (ADS)

Mollaioli, Fabrizio; Bruno, Silvia; Decanini, Luis; Saragoni, Rodolfo

2011-01-01

The development of a scientific framework for performance-based seismic engineering requires, among other steps, the evaluation of ground motion intensity measures at a site and the characterization of their relationship with suitable engineering demand parameters (EDPs) which describe the performance of a structure. In order to be able to predict the damage resulting from earthquake ground motions in a structural system, it is first necessary to properly identify ground motion parameters that are well correlated with structural response and, in turn, with damage. Since structural damage during an earthquake ground motion may be due to excessive deformation or to cumulative cyclic damage, reliable methods for estimating displacement demands on structures are needed. Even though the seismic performance is directly related to the global and local deformations of the structure, energy-based methodologies appear more helpful in concept, as they permit a rational assessment of the energy absorption and dissipation mechanisms that can be effectively accomplished to balance the energy imparted to the structure. Moreover, energy-based parameters are directly related to cycles of response of the structure and, therefore, they can implicitly capture the effect of ground motion duration, which is ignored by conventional spectral parameters. Therefore, the identification of reliable relationships between energy and displacement demands represents a fundamental issue in both the development of more reliable seismic code provisions and the evaluation of seismic vulnerability aimed at the upgrading of existing hazardous facilities. As these two aspects could become consistently integrated within a performance-based seismic design methodology, understanding how input and dissipated energy are correlated with displacement demands emerges as a decisive prerequisite. The aim of the present study is the establishment of functional relationships between input and dissipated energy (that can be considered as parameters representative of the amplitude, frequency content and duration of earthquake ground motions) and displacement-based response measures that are well correlated to structural and non-structural damage. For the purpose of quantifying the EDPs to be related to the energy measures, for comprehensive range of ground motion and structural characteristics, both simplified and more accurate numerical models will be used in this study for the estimation of local and global displacement and energy demands. Parametric linear and nonlinear time-history analyses will be performed on elastic and inelastic SDOF and MDOF systems, in order to assume information on the seismic response of a wide range of current structures. Hysteretic models typical of frame force/displacement behavior will be assumed for the local inelastic cyclic response of the systems. A wide range of vibration periods will be taken into account so as to define displacement, interstory drift and energy spectra for MDOF systems. Various scalar measures related to the deformation demand will be used in this research. These include the spectral displacements, the peak roof drift ratio, and the peak interstory drift ratio. A total of about 900 recorded ground motions covering a broad variety of condition in terms of frequency content, duration and amplitude will be used as input in the dynamic analyses. The records are obtained from 40 earthquakes and grouped as a function of magnitude of the event, source-to-site condition and site soil condition. In addition, in the data-set of records a considerable number of near-fault signals is included, in recognition of the particular significance of pulse-like time histories in causing large seismic demands to the structures.

Advantages of statistical analysis of giant vesicle flickering for bending elasticity measurements.

PubMed

Méléard, P; Pott, T; Bouvrais, H; Ipsen, J H

2011-10-01

We show how to greatly improve precision when determining bending elasticity of giant unilamellar vesicles. Taking advantage of the well-known quasi-spherical model of liposome flickering, we analyze the full probability distributions of the configurational fluctuations instead of limiting the analysis to the second moment measurements only as usually done in previously published works. This leads to objective criteria to reject vesicles that do not behave according to the model. As a result, the confidence in the bending elasticity determination of individual vesicles that fit the model is improved and, consequently, the reproducibility of this measurement for a given membrane system. This approach uncovers new possibilities for bending elasticity studies like detection of minute influences by solutes in the buffer or into the membrane. In the same way, we are now able to detect the inhomogeneous behavior of giant vesicle systems such as the hazardous production of peroxide in bilayers containing fluorescent dyes. © EDP Sciences / Società Italiana di Fisica / Springer-Verlag 2011

Boiling sheep liver or lung for 30 minutes is necessary and sufficient to kill Echinococcus granulosus protoscoleces in hydatid cysts.

PubMed

Li, Jun; Wu, Chuanchuan; Wang, Hui; Liu, Huanyuan; Vuitton, Dominique A; Wen, Hao; Zhang, Wenbao

2014-01-01

Proper disposal of carcasses and offal after home slaughter is difficult in poor and remote communities and therefore dogs readily have access to hydatid cysts containing offal from livestock, thus completing the parasite cycle of Echinococcus granulosus and putting communities at risk of cystic echinococcosis. Boiling livers and lungs which contain hydatid cysts could be a simple, efficient and energy- and time-saving way to kill the infectious protoscoleces. The aim of this study was to provide precise practical recommendations to livestock owners. Our results show that boiling the whole sheep liver and/or lung, with single or multiple hydatid cysts, for 30 min is necessary and sufficient to kill E. granulosus protoscoleces in hydatid cysts. Advertising on this simple rule in at-risk communities would be an efficient and cheap complement to other veterinary public health operations to control cystic echinococcosis. © J. Li et al., published by EDP Sciences, 2014.

Meningoencephalitis due to the amoeboflagellate Naegleria fowleri in ruminants in Algeria.

PubMed

Benterki, Mohamed Seghir; Ayachi, Ammar; Bennoune, Omar; Régoudis, Estelle; Pélandakis, Michel

2016-01-01

Primary amoebic meningoencephalitis (PAM) is a fatal infection in most cases, caused by the amoeba flagellate Naegleria fowleri. This report describes the first cases of PAM in Algeria, in a cow and a ewe from Batna, north-eastern Algeria. The death of both ruminants occurred a week after the first clinical manifestations. The cerebrospinal fluid, after staining with May-Grünwald-Giemsa, showed the presence of amoebae cells. Histological sections revealed numerous amoebae in all parts of the brain. The presence of N. fowleri was confirmed using a species-specific real-time PCR in histological tissue sections. The two PAM cases were reported during the hot season, and the source of infection is very likely the water where the cattle came to drink. Particular attention should be focused on this type of infection in aquatic environments when the temperature is high and preventive measures must be taken to avoid the proliferation of N. fowleri. © M. Benterki et al., published by EDP Sciences, 2016.

Seroprevalence of Toxoplasma gondii infection in zoo and domestic animals in Jiangxi Province, China.

PubMed

Luo, Houqiang; Li, Kun; Zhang, Hui; Gan, Ping; Shahzad, Muhammad; Wu, Xiaoxing; Lan, Yanfang; Wang, Jiaxiang

2017-01-01

Toxoplasma gondii is a zoonotic protozoan parasite that infects a wide range of warm-blooded animals throughout the world. In the present study, antibodies to T. gondii were determined using a commercial indirect hemagglutination (IHA) test in wild animals in a zoo. Three of 11 giraffes (Giraffa camelopardalis) (27%), 1 of 5 wolves (Canis lupus laniger) (20%), 1 of 6 hippopotamuses (Hippopotamus amphibious) (17%), and 2 of 9 tundra swans (Cygnus columbianus) (22%) were found to be positive. No antibodies were detected in leopards (Panthera pardus), wild geese (Anser cygnoides), and Eastern grey kangaroos (Macropus giganteus). Domestic species from 13 counties of Jiangxi Province, China were also investigated by an indirect hemagglutination (IHA) test. Thirty-five of 340 goats (10%), 94 of 560 water buffaloes (17%), and 4 of 35 cattle (11%) were found to be seropositive. This is the first report of T. gondii infection in animals kept in zoos and domestic animals in this province. © H. Luo et al., published by EDP Sciences, 2017.

Factor Structure and Psychometric Properties of English and Spanish Versions of the Edinburgh Postnatal Depression Scale Among Hispanic Women in a Primary Care Setting

PubMed Central

Hartley, Chelsey M.; Barroso, Nicole; Rey, Yasmin; Pettit, Jeremy W.; Bagner, Daniel M.

2015-01-01

Background Although a number of studies have examined the factor structure of the Edinburgh Postnatal Depression Scale (EPDS) in predominately White or African American samples, no published research has reported on the factor structure among Hispanic women who reside in the United States. Objective The current study examined the factor structure of the EPDS among Hispanic mothers in the United States. Method Among 220 Hispanic women, drawn from a pediatric primary care setting, with an infant aged 0 to 10 months, 6 structural models guided by the empirical literature were evaluated using confirmatory factor analysis. Results Results supported a 2-factor model of depression and anxiety as the best fitting model. Multigroup models supported the factorial invariance across women who completed the EDPS in English and Spanish. Conclusion These findings provide initial support for the 2-factor structure of the EPDS among Hispanic women in the United States. PMID:24807217

[Influence of trigeminal nerve lesion on facial growth: study of two cases of Goldenhar syndrome].

PubMed

Darris, Pierre; Treil, Jacques; Marchal-Sixou, Christine; Baron, Pascal

2015-06-01

This cases report confirms the hypothesis that embryonic and maxillofacial growth are influenced by the peripheral nervous system, including the trigeminal nerve (V). So, it's interesting to use the stigma of the trigeminal nerve as landmarks to analyze the maxillofacial volume and understand its growth. The aim of this study is to evaluate the validity of the three-dimensional cephalometric analysis of Treil based on trigeminal landmarks. The first case is a caucasian female child with Goldenhar syndrome. The second case is a caucasian male adult affected by the same syndrome. In both cases, brain MRI showed an unilateral trigeminal nerve lesion, ipsilateral to the facial dysmorphia. The results of this radiological study tend to prove the primary role of the trigeminal nerve in craniofacial growth. These cases demonstrate the validity of the theory of Moss. They are one of anatomo-functional justifications of the three-dimensional cephalometric biometry of Treil based on trigeminal nerve landmarks. © EDP Sciences, SFODF, 2015.

[Craniomandibular relations and anti-gravity posture: stabilometric study disclusion wedges].

PubMed

Decocq, Philippe; Honoré, Jacques; Auclair-Assaad, Catherine; Sequeira, Henrique; Bocquet, Emmanuelle

2015-06-01

Cephalometric parameters are thought to influence static posture. The present work evaluates the relationships between skeletal class or facial divergency, on one hand, and body posture, on the other hand. ANB and FMA angles were measured from profile cephalograms in twenty healthy adults. From each, stabilograms were recorded, with eyes open or shut, and with or without disclusion splints. Without splints, ANB and FMA proved to correlate with the accuracy of postural control. Adding splints changes the average position of the center of pressure exerted on the ground by the body, the anterior-posterior axis, and this effect is consistent with that of the typology. It also alters the displacement of the center of pressure on the same axis. These effects depend on whether the eyes are open or closed. The data reinforces the notion of the impact of cephalometric parameters and their mechanical changes on the static posture. They invite us to take greater account of postural impact of splints used in orthodontic practice. © EDP Sciences, SFODF, 2015.

Factor structure and psychometric properties of english and spanish versions of the edinburgh postnatal depression scale among Hispanic women in a primary care setting.

PubMed

Hartley, Chelsey M; Barroso, Nicole; Rey, Yasmin; Pettit, Jeremy W; Bagner, Daniel M

2014-12-01

Although a number of studies have examined the factor structure of the Edinburgh Postnatal Depression Scale (EPDS) in predominately White or African American samples, no published research has reported on the factor structure among Hispanic women who reside in the United States. The current study examined the factor structure of the EPDS among Hispanic mothers in the United States. Among 220 Hispanic women, drawn from a pediatric primary care setting, with an infant aged 0 to 10 months, 6 structural models guided by the empirical literature were evaluated using confirmatory factor analysis. Results supported a 2-factor model of depression and anxiety as the best fitting model. Multigroup models supported the factorial invariance across women who completed the EDPS in English and Spanish. These findings provide initial support for the 2-factor structure of the EPDS among Hispanic women in the United States. © 2014 Wiley Periodicals, Inc.

[Course of action in front of children or adolescent suffering from temporomandibular disorders].

PubMed

Robin, Olivier

2013-03-01

Temporomandibular disorders are described in children from the age of 4. Their prevalence and severity increase strongly during the second decade, which corresponds to the period of orthodontic treatments. At this age the most common symptoms are joint clicking sounds (more than 70% of the cases), sometimes accompanied by episodes of intermittent locking. They would be favored by oral parafunctional activities (gum chewing, biting habits, bruxism...), ligamentous hyperlaxity and modification of the intra-articular space relations during growth. The questioning of the patient and his parents and clinical examination (muscular, articular and occlusal) are essential and very often sufficient for establishing the diagnosis. Even more than in the adult, the therapeutic attitude must rely on conservative and non-irreversible methods (explanations, suppression of the parafunctions, occlusal splints in the case of severe bruxism). These considerations are illustrated by the presentation of two representative clinical cases of temporomandibular disorders frequently encountered in children and adolescents. © EDP Sciences, SFODF, 2013.

Prevalence of Dermanyssus gallinae (Mesostigmata: Dermanyssidae) in industrial poultry farms in North-East Tunisia.

PubMed

Gharbi, Mohamed; Sakly, Nadhem; Darghouth, Mohamed Aziz

2013-01-01

Dermanyssus gallinae (Mesostigmata: Dermanyssidae), a mite of poultry, represents the most important ecotoparasite of egg-laying poultry in several countries. We estimated the prevalence of D. gallinae infestation in 38 industrial poultry farms (28 egg-laying and 10 reproductive hen farms) in the governorate of Nabeul (North-East Tunisia). Traps were placed in two locations of each farm during 24 h in August. The overall prevalence at the farms was estimated to be 34%. A total number of 329 D. gallinae were collected, giving an intensity of 0.0028 and an abundance of 0.0015. Infestation intensity and abundance were significantly higher in egg production farms than reproductive farms. There was no correlation between the intensity of infestation and temperature. An exponential correlation was observed between the birds' age and infestation intensity. We recommend a systematic survey of poultry farms during the whole breeding period. Prompt treatment is recommended to avoid the exponential increase of mite population. © M. Gharbi et al., published by EDP Sciences, 2013.

[Diagnosis and treatment of temporo-mandibular disorders in orthodontics].

PubMed

Bocquet, Emmanuelle; Moreau, Alexis; Danguy, Michel; Danguy, Chantal

2010-03-01

Orthodontists are fully prepared to treat the problems of occlusion that they are called upon to deal with every day. On the other hand temporo-mandibular joint disorders present more obscure difficulties from the point of view of detection and diagnosis as well the management of their treatment. That is why a profound understanding of the anatomical and physiological functioning of the temporo-mandibular joint has become indispensable for today's orthodontists who are now asked to detect and diagnose an assortment of TMJ disturbances whose etiology may vary greatly. By performing a rigorous diagnostic procedure, based on a thorough clinical examination supported by careful axiographic and radiological studies, of temporo-mandibular malfunctioning and its underlying etiological causes, which are primarily dento-alveolar and occlusal in nature, orthodontists will be able to adopt an appropriate therapeutic approach that might be purely orthodontic or multi-disciplinary and carried out with the collaboration of specialists in occlusion, oral surgery, and even osteopathy. EDP Sciences, SFODF, 2010.

[Maxillo-facial surgery in skeletal Class II: repercussions on the temporo-mandibular joints].

PubMed

Manière-Ezvan, Armelle; Savoldelli, Charles; Busson, Floriant; Oueiss, Arlette; Orthlieb, Jean-Daniel

2016-03-01

These interventions usually aimed at the correction of the skeletal discrepancy by mandibular retrognatism with an advancement of the distal portion of the mandible after mandibular osteotomy. The position of the condyle is determined during the osteosynthesis with miniplates. Condyles are set back in relation with the supine position of the patient and the weakness of his (her) curarized muscle. All studies show that surgery of mandibular advancement causes a lateral, torque and backward movement of the condyles, all harmful to the condyles. Factors that predispose to condylar resorption are "the patient": a woman, young (between 15 and 40), high mandibular angle, with a history of temporo-mandibular disorders and surgical overload applied to the condyles. What are the possible solutions to avoid failures? Patient preparation before surgery and surgery simulation with an articulator, condylar position control during surgery, working with surgeons to achieve a condylar portion stabilization system (with the CAD), quickly set up a mobilization of the mandible by physiotherapy. © EDP Sciences, SFODF, 2016.

Seroprevalence of Toxoplasma gondii in wild boars, red deer and roe deer in Poland.

PubMed

Witkowski, Lucjan; Czopowicz, Michał; Nagy, Dan Alexandru; Potarniche, Adrian Valentin; Aoanei, Monica Adriana; Imomov, Nuriddin; Mickiewicz, Marcin; Welz, Mirosław; Szaluś-Jordanow, Olga; Kaba, Jarosław

2015-01-01

Little is known about the prevalence of Toxoplasma gondii in wild life, particularly game animals in Poland. Meat juice collected during the 2009/2010 and 2010/2011 hunting seasons from 552 red deer (Cervus elaphus), 367 wild boars (Sus scrofa) and 92 roe deer (Capreolus capreolus) was tested for T. gondii antibodies using the multi-species ID Screen Toxoplasmosis Indirect kit (IDvet, Montpellier, France). Antibodies to T. gondii were detected in 24.1% of red deer (95% CI: 20.7%, 27.8%), 37.6% of wild boar (95% CI: 32.8%, 42.7%) and 30.4% of roe deer (95% CI: 22.0%, 40.5%). To the authors' best knowledge, this is the first epidemiological report of T. gondii prevalence in red deer, roe deer and wild boars in Poland. T. gondii is present in wildlife animal tissues and consumption of the game may be a potential source of infection for humans. © L. Witkowski et al., published by EDP Sciences, 2015.

Developing risk hypotheses and selecting species for assessing non-target impacts of GM trees with novel traits: the case of altered-lignin pine trees.

PubMed

Malone, Louise A; Todd, Jacqui H; Burgess, Elisabeth P J; Walter, Christian; Wagner, Armin; Barratt, Barbara I P

2010-01-01

A procedure is presented for developing environmental risk hypotheses associated with the deployment of forest trees genetically modified to have altered wood properties and for selecting non-target species to test these hypotheses. Altered-lignin Pinus radiata trees intended for use in New Zealand are used as a hypothetical case study to illustrate our approach. Firstly, environmental management goals (such as wood production, flood control or preservation of biodiversity) were identified and linked to the forest attributes they require. Necessary conditions for each attribute were listed and appropriate assessment endpoints for them developed. For example, biological control of pests may be one condition necessary for a forest to have healthy trees, and the diversity and abundance of natural enemy species in the forest could be an appropriate assessment endpoint for measuring this condition. A conceptual model describing the relationships between an altered-lignin GM pine tree and potentially affected invertebrates and micro-organisms in a plantation forest was used to develop a set of risk hypotheses describing how the GM trees might affect each assessment endpoint. Because purified lignin does not represent the properties it imparts to wood, maximum hazard dose tests with non-target organisms, as are used to inform toxin risk assessment, cannot be conducted. Alternative experiments, based on current knowledge of the responses of organisms to lignin, must be designed. A screening method was adapted and applied to a database of invertebrate species known to inhabit New Zealand pine forests to identify and prioritize non-target invertebrate species that could be used as experimental subjects for examining these hypotheses. The screening model and its application are presented, along with a set of recommendations for pre-release tests with GM pines and potentially affected invertebrates and micro-organisms. © ISBR, EDP Sciences, 2011.

Developing biosafety risk hypotheses for invertebrates exposed to GM plants using conceptual food webs: a case study with elevated triacylglyceride levels in ryegrass.

PubMed

Barratt, Barbara I P; Todd, Jacqui H; Burgess, Elisabeth P J; Malone, Louise A

2010-01-01

Regulators are acutely aware of the need for meaningful risk assessments to support decisions on the safety of GM crops to non-target invertebrates in determining their suitability for field release. We describe a process for developing appropriate, testable risk hypotheses for invertebrates in agroecosystems that might be exposed to plants developed by GM and future novel technologies. An existing model (PRONTI) generates a ranked list of invertebrate species for biosafety testing by accessing a database of biological, ecological and food web information about species which occur in cropping environments and their potential interactions with a particular stressor (Eco Invertebase). Our objective in this contribution is to explore and further utilise these resources to assist in the process of problem formulation by identifying potentially significant effects of the stressor on the invertebrate community and the ecosystem services they provide. We propose that for high ranking species, a conceptual food web using information in Eco Invertebase is constructed, and using an accepted regulatory risk analysis framework, the likelihood of risk, and magnitude of impact for each link in the food web is evaluated. Using as filters only those risks evaluated as likely to extremely likely, and the magnitude of an effect being considered as moderate to massive, the most significant potential effects can be identified. A stepwise approach is suggested to develop a sequence of appropriate tests. The GM ryegrass plant used as the "stressor" in this study has been modified to increase triacylglyceride levels in foliage by 100% to increase the metabolisable energy content of forage for grazing animals. The high-ranking "test" species chosen to illustrate the concept are New Zealand native species Wiseana cervinata (Walker) (Lepidoptera: Hepialidae), Persectania aversa (Walker) (Lepidoptera: Noctuidae), and the self-introduced grey field slug, Deroceras reticulatum (Müller). © ISBR, EDP Sciences, 2011.

MED: a new non-supervised gene prediction algorithm for bacterial and archaeal genomes.

PubMed

Zhu, Huaiqiu; Hu, Gang-Qing; Yang, Yi-Fan; Wang, Jin; She, Zhen-Su

2007-03-16

Despite a remarkable success in the computational prediction of genes in Bacteria and Archaea, a lack of comprehensive understanding of prokaryotic gene structures prevents from further elucidation of differences among genomes. It continues to be interesting to develop new ab initio algorithms which not only accurately predict genes, but also facilitate comparative studies of prokaryotic genomes. This paper describes a new prokaryotic genefinding algorithm based on a comprehensive statistical model of protein coding Open Reading Frames (ORFs) and Translation Initiation Sites (TISs). The former is based on a linguistic "Entropy Density Profile" (EDP) model of coding DNA sequence and the latter comprises several relevant features related to the translation initiation. They are combined to form a so-called Multivariate Entropy Distance (MED) algorithm, MED 2.0, that incorporates several strategies in the iterative program. The iterations enable us to develop a non-supervised learning process and to obtain a set of genome-specific parameters for the gene structure, before making the prediction of genes. Results of extensive tests show that MED 2.0 achieves a competitive high performance in the gene prediction for both 5' and 3' end matches, compared to the current best prokaryotic gene finders. The advantage of the MED 2.0 is particularly evident for GC-rich genomes and archaeal genomes. Furthermore, the genome-specific parameters given by MED 2.0 match with the current understanding of prokaryotic genomes and may serve as tools for comparative genomic studies. In particular, MED 2.0 is shown to reveal divergent translation initiation mechanisms in archaeal genomes while making a more accurate prediction of TISs compared to the existing gene finders and the current GenBank annotation.

Haemonchotolerance in West African Dwarf goats: contribution to sustainable, anthelmintics-free helminth control in traditionally managed Nigerian dwarf goats.

PubMed

Chiejina, Samuel N; Behnke, Jerzy M; Fakae, Barineme B

2015-01-01

West African Dwarf (WAD) goats are extremely important in the rural village economy of West Africa, but still little is known about their biology, ecology and capacity to cope with gastrointestinal nematode (GIN) infections. Here, we summarise the history of this breed and explain its economic importance in rural West Africa. We review recent work showing that Nigerian WAD goats are highly trypanotolerant and resist infections with Haemonchus contortus more effectively than other breeds of domestic goat (haemonchotolerance). We believe that haemonchotolerance is largely responsible for the generally low level GIN infections and absence of clinical haemonchosis in WADs under field conditions, and has contributed to the relatively successful and sustainable, anthelmintics-free, small-scale system of goat husbandry in Nigeria's humid zone, and is immunologically based and genetically controlled. If haemonchotolerance can be shown to be genetically controlled, it should be possible to exploit the underlying genes to improve GIN resistance among productive fibre and milk producing breeds of goats, most of which are highly susceptible to nematode infections. Genetic resistance to GIN and trypanosome infections would obviate the need for expensive chemotherapy, mostly unaffordable to small-holder farmers in Africa, and a significant cost of goat husbandry in more developed countries. Either introgression of resistance alleles into susceptible breeds by conventional breeding, or transgenesis could be used to develop novel parasite-resistant, but highly productive breeds, or to improve the resistance of existing breeds, benefitting the local West African rural economy as well as global caprine livestock agriculture. © S.N. Chiejina et al., published by EDP Sciences, 2015.

Bi/In thermal resist for both Si anisotropic wet etching and Si/SiO2 plasma etching

NASA Astrophysics Data System (ADS)

Chapman, Glenn H.; Tu, Yuqiang; Peng, Jun

2004-01-01

Bi/In thermal resist is a bilayer structure of Bi over In films which can be exposed by laser with a wide range of wavelengths and can be developed by diluted RCA2 solutions. Current research shows bimetallic resist can work as etch masking layer for both dry plasma etching and wet anisotropic etching. It can act as both patterning and masking layers for Si and SiO2 with plasma "dry" etch using CF4/CHF3. The etching condition is CF4 flow rate 50 sccm, pressure 150 mTorr, and RF power 100 - 600W. The profile of etched structures can be tuned by adding CHF3 and other gases such as Ar, and by changing the CF4/CHF3 ratio. Depending on the fluorocarbon plasma etching recipe the etch rate of laser exposed Bi/In can be as low as 0.1 nm/min, 500 times lower than organic photoresists. O2 plasma ashing has little etching effect on exposed Bi/In. Bi/In also creates etch masking layers for alkaline-based (KOH, TMAH and EDP) "wet" anisotropic bulk Si etch without the need of SiO2 masking steps. The laser exposed Bi/In etches two times more slowly than SiO2. Experiment result shows that single metal Indium film exhibits thermal resist characteristics but at twice the exposure levels. It can be developed in diluted RCA2 solution and used as an etch mask layer for Si anisotropic etch. X-ray diffraction analysis shows that laser exposure causes both Bi and In single film to oxidize. In film may become amorphous when exposed to high laser power.

A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice.

PubMed

Carbone, Salvatore; Mauro, Adolfo G; Mezzaroma, Eleonora; Kraskauskas, Donatas; Marchetti, Carlo; Buzzetti, Raffaella; Van Tassell, Benjamin W; Abbate, Antonio; Toldo, Stefano

2015-11-01

Heart failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, exercise intolerance and cardiac dysfunction. Unhealthy diet has been associated with increased risk of obesity and heart disease, but whether it directly affects cardiac function, and promotes the development and progression of HF is unknown. We fed 8-week old male or female CD-1 mice with a standard diet (SD) or a diet rich in saturated fat and sugar, resembling a "Western" diet (WD). Cardiac systolic and diastolic function was measured at baseline and 4 and 8 weeks by Doppler echocardiography, and left ventricular (LV) end-diastolic pressure (EDP) by cardiac catheterization prior to sacrifice. An additional group of mice received WD for 4 weeks followed by SD (wash-out) for 8 weeks. WD-fed mice experienced a significant decreased in LV ejection fraction (LVEF), reflecting impaired systolic function, and a significant increase in isovolumetric relaxation time (IRT), myocardial performance index (MPI), and LVEDP, showing impaired diastolic function, without any sex-related differences. Switching to a SD after 4 weeks of WD partially reversed the cardiac systolic and diastolic dysfunction. A diet rich in saturated fat and sugars (WD) impairs cardiac systolic and diastolic function in the mouse. Further studies are required to define the mechanism through which diet affects cardiac function, and whether dietary interventions can be used in patients with, or at risk for, HF. Published by Elsevier Ireland Ltd.

Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s.

PubMed

Akono Ntonga, Patrick; Baldovini, Nicolas; Mouray, Elisabeth; Mambu, Lengo; Belong, Philippe; Grellier, Philippe

2014-01-01

The biological activities of essential oils from three plants grown in Cameroon: Ocimum basilicum, Ocimum canum, and Cymbopogon citratus were tested against Plasmodium falciparum and mature-stage larvae of Anopheles funestus. Gas chromatography and gas chromatography - mass spectrometry analyses showed that the main compounds are geranial, 1,8-cineole and linalool in C. citratus, O. canum and O. basilicum, respectively. Larvicidal tests carried out according to the protocol recommended by the World Health Organization showed that the essential oil of leaves of C. citratus is the most active against larvae of An. funestus (LC50 values = 35.5 ppm and 34.6 ppm, respectively, for larval stages III and IV after 6 h of exposure). Besides, the in vitro anti-plasmodial activity evaluated by the radioisotopic method showed that the C. citratus oil is the most active against P. falciparum, with an IC50 value of 4.2 ± 0.5 μg/mL compared with O. canum (20.6 ± 3.4 μg/mL) and O. basilicum (21 ± 4.6 μg/mL). These essential oils can be recommended for the development of natural biocides for fighting the larvae of malaria vectors and for the isolation of natural products with anti-malarial activity. © P. Akono Ntonga et al., published by EDP Sciences, 2014.

Detection of Toxoplasma gondii DNA by qPCR in the feces of a cat that recently ingested infected prey does not necessarily imply oocyst shedding.

PubMed

Poulle, Marie-Lazarine; Forin-Wiart, Marie-Amélie; Josse-Dupuis, Émilie; Villena, Isabelle; Aubert, Dominique

2016-01-01

Detection of Toxoplasma gondii DNA in cat feces is considered indicative of the presence of T. gondii oocysts. This study aims to demonstrate that the high sensitivity of qPCR can lead to T. gondii DNA detection in cat feces in the absence of oocysts. A cat immune to toxoplasmosis was fed with a mouse experimentally infected with T. gondii. Detection of DNA of this parasite was performed by qPCR on feces passed: (i) on the day the cat ingested the infected prey; (ii) during the three previous days; and (iii) during the three following days. The kinetics of qPCR results are clearly not linked to oocyst shedding and this result demonstrates that qPCR can detect T. gondii DNA related to bradyzoites from an infected prey, in the absence of oocysts. Caution is thus recommended when interpreting T. gondii qPCR results for samples of cat feces. © M.-L. Poulle et al., published by EDP Sciences, 2016.

Application of source biasing technique for energy efficient DECODER circuit design: memory array application

NASA Astrophysics Data System (ADS)

Gupta, Neha; Parihar, Priyanka; Neema, Vaibhav

2018-04-01

Researchers have proposed many circuit techniques to reduce leakage power dissipation in memory cells. If we want to reduce the overall power in the memory system, we have to work on the input circuitry of memory architecture i.e. row and column decoder. In this research work, low leakage power with a high speed row and column decoder for memory array application is designed and four new techniques are proposed. In this work, the comparison of cluster DECODER, body bias DECODER, source bias DECODER, and source coupling DECODER are designed and analyzed for memory array application. Simulation is performed for the comparative analysis of different DECODER design parameters at 180 nm GPDK technology file using the CADENCE tool. Simulation results show that the proposed source bias DECODER circuit technique decreases the leakage current by 99.92% and static energy by 99.92% at a supply voltage of 1.2 V. The proposed circuit also improves dynamic power dissipation by 5.69%, dynamic PDP/EDP 65.03% and delay 57.25% at 1.2 V supply voltage.

[Indirect usage of miniscrew anchorage to intrude overerupted mandibular incisors in a Class II patient with a deep overbite].

PubMed

Ishihara, Yoshihito; Kuroda, Shingo; Sugawara, Yasuyo; Balam, Tarek A; Takano-Yamamoto, Teruko; Yamashiro, Takashi

2016-06-01

Vertical dentoalveolar discrepancies are a common problem in orthodontic patients but are often difficult to treat with traditional mechanics. This case report illustrates the successful treatment of overerupted mandibular incisors via the indirect use of miniscrew anchorage. A woman (age, 22 years 9 months) had chief complaints of maxillary incisor protrusion and crooked teeth. An excessive curve of Spee caused by elongation of the mandibular incisors was also found. The patient was diagnosed with a severe Class II Division 1 malocclusion and a deep overbite. After extraction of the mandibular first premolars and the subsequent leveling phase, the elongated incisors were intruded with a novel method, which involved the combined use of sectional archwires and miniscrews placed in the premolar areas. After the procedure, the mandibular incisors had been intruded by 6.5 mm with no undesirable side effects. The total active treatment period was 42 months. The resultant occlusion and satisfactory facial profile were maintained after 30 months of retention. Our novel intrusion approach shows potential for correcting a deep overbite. © EDP Sciences, SFODF, 2016.

Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico.

PubMed

Yeargan, Michelle R; Alvarado-Esquivel, Cosme; Dubey, Jitender P; Howe, Daniel K

2013-01-01

Equine protozoal myeloencephalitis (EPM) is a debilitating disease of horses caused by Sarcocystis neurona and Neospora hughesi. Sera from 495 horses in Durango State, Mexico were tested for anti-protozoal antibodies using enzyme-linked immunosorbent assays (ELISAs) based on major surface antigens of these two parasites. Antibodies to S. neurona were detected in 240 (48.5%) of the 495 horse sera tested with the rSnSAG2/4/3 trivalent ELISA. Multivariate analysis showed that exposure to S. neurona was associated with age, feeding grains and crops, and small herd size. Antibodies to N. hughesi were found in 15 (3.0%) of the 495 horse sera tested with the rNhSAG1 ELISA and confirmed by Western blot of N. hughesi tachyzoite antigen. This is the first report of S. neurona and N. hughesi exposure in horses in Mexico, and it affirms that EPM should be in the differential diagnosis for horses exhibiting signs of neurologic disease in this country. © M.R. Yeargan et al., published by EDP Sciences, 2013.

Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles.

PubMed

Palm, Mélanie; Garigliany, Mutien-Marie; Cornet, François; Desmecht, Daniel

2010-01-01

The interferon-induced Mx proteins of vertebrates are dynamin-like GTPases, some isoforms of which can additionally inhibit the life cycle of certain RNA viruses. Here we show that the porcine Mx1 protein (poMx1) inhibits replication of influenza A virus and we attempt to identify the step at which the viral life cycle is blocked. In infected cells expressing poMx1, the level of transcripts encoding the viral nucleoprotein is significantly lower than normal, even when secondary transcription is prevented by exposure to cycloheximide. This reveals that a pretranscriptional block participates to the anti-influenza activity. Binding and internalization of incoming virus particles are normal in the presence of poMx1 but centripetal traffic to the late endosomes is interrupted. Surprisingly but decisively, poMx1 significantly alters binding of early endosome autoantigen 1 to early endosomes and/or early endosome size and spatial distribution. This is compatible with impairment of traffic of the endocytic vesicles to the late endosomes. INRA, EDP Sciences, 2010.

First molecular investigation of Cryptosporidium spp. in young calves in Algeria.

PubMed

Benhouda, Djahida; Hakem, Ahcène; Sannella, Anna Rosa; Benhouda, Afaf; Cacciò, Simone M

2017-01-01

To date, no information is available on the prevalence and genetic identity of Cryptosporidium spp. in cattle in Algeria. In this study, 17 dairy farms in the province of Batna, located in the northeast of the country, were visited to collect 132 fecal samples from young calves (< 8 weeks old). Samples were examined microscopically using the modified Ziehl-Neelsen acid-fast staining method, and at least one sample per farm was submitted for molecular analysis. Amplification of a fragment of the small subunit ribosomal RNA gene was positive for 24 of the 61 samples (40%), and sequence analysis identified three species, namely Cryptosporidium bovis (n = 14), C. ryanae (n = 6), and C. parvum (n = 4). The C. parvum IIaA13G2R1 subtype, an uncommon zoonotic subtype, was identified in two isolates from a single farm by sequencing a fragment of the GP60 gene. This is the first report about genotyping and subtyping of Cryptosporidium in calves in Algeria. © D. Benhouda et al., published by EDP Sciences, 2017.

EELS Analysis of Nylon 6 Nanofibers Reinforced with Nitroxide-Functionalized Graphene Oxide.

PubMed

Leyva-Porras, César; Ornelas-Gutiérrez, C; Miki-Yoshida, M; Avila-Vega, Yazmín I; Macossay, Javier; Bonilla-Cruz, José

2014-01-01

A detailed analysis by transmission electron microscopy (TEM) and electron energy loss spectroscopy (EELS) of nitroxide-functionalized graphene oxide layers (GOFT) dispersed in Nylon 6 nanofibers is reported herein. The functionalization and exfoliation process of graphite oxide to GOFT was confirmed by TEM using electron diffraction patterns (EDP), wherein 1 to 4 graphene layers of GOFT were observed. The distribution and alignment of GOFT layers within a sample of Nylon 6 nanofiber reveals that GOFT platelets are mainly within the fiber, but some were partially protruding from it. Furthermore, Nylon 6 nanofibers exhibit an average diameter of 225 nm with several microns in length. GOFT platelets embedded into the fiber, the pristine fiber, and amorphous carbon were analyzed by EELS where each spectra [corresponding to the carbon edge (C-K)] exhibited changes in the fine structure, allowing a clear distinction between: i) GOFT single-layers, ii) Nylon-6 nanofibers, and iii) the carbon substrate. EELS analysis is presented here for the first time as a powerful tool to identify functionalized graphene single-layers (< 4 layers of GOFT) into a Nylon 6 nanofiber composite.

[How to evaluate psychological risks: an ethics of aesthetic demand in orthodontics].

PubMed

Benkimoun, Franck

2015-12-01

Evaluating risks is part of the day-to-day practice of all orthodontists. Most of the time we forget that healing a patient also requires an evaluation of what is called the psychological risk. Indeed, focusing on harmonisation matters, we tend to omit that patient's requests, especially aesthetic requests, may conceal psychological problems. Such a risk is even higher when it comes to orthodontic-surgical protocols, as the physical changes are more radical. We will discuss the specificities of aesthetical demand, its links with the social discourse and the way self-esteem and reflection in the mirror are closely intermingled. Should we forget to take into account the psychological dimension of any patient, this could be a breach of professional ethics. We will furthermore consider the means we have to recognize patients with a high psychological risk. It is not in our hands to help these patients psychologically. It is in the hands of a mental health specialist, whose adress and phone number we should know in order to refer our patients to him/her. © EDP Sciences, SFODF, 2015.

EELS Analysis of Nylon 6 Nanofibers Reinforced with Nitroxide-Functionalized Graphene Oxide

PubMed Central

Leyva-Porras, César; Ornelas-Gutiérrez, C.; Miki-Yoshida, M.; Avila-Vega, Yazmín I.; Macossay, Javier; Bonilla-Cruz, José

2014-01-01

A detailed analysis by transmission electron microscopy (TEM) and electron energy loss spectroscopy (EELS) of nitroxide-functionalized graphene oxide layers (GOFT) dispersed in Nylon 6 nanofibers is reported herein. The functionalization and exfoliation process of graphite oxide to GOFT was confirmed by TEM using electron diffraction patterns (EDP), wherein 1 to 4 graphene layers of GOFT were observed. The distribution and alignment of GOFT layers within a sample of Nylon 6 nanofiber reveals that GOFT platelets are mainly within the fiber, but some were partially protruding from it. Furthermore, Nylon 6 nanofibers exhibit an average diameter of 225 nm with several microns in length. GOFT platelets embedded into the fiber, the pristine fiber, and amorphous carbon were analyzed by EELS where each spectra [corresponding to the carbon edge (C-K)] exhibited changes in the fine structure, allowing a clear distinction between: i) GOFT single-layers, ii) Nylon-6 nanofibers, and iii) the carbon substrate. EELS analysis is presented here for the first time as a powerful tool to identify functionalized graphene single-layers (< 4 layers of GOFT) into a Nylon 6 nanofiber composite. PMID:24634536

[Alveolar bone thickness in A point area : how to avoid periodontal failures in front of upper incisors].

PubMed

Chevalier, Émilie; Philip-Alliez, Camille; Le Gall, Michel

2016-03-01

Studies on orthodontic-periodontics relationships are numerous but few have benefited from the contribution of new 3D imaging techniques that emphasize iatrogenic effects that orthodontics may have on the periodontium. Periodontal risk in terms of fenestration, bone dehiscences next maxillary incisors are real during or after orthodontic treatment. The accurate assessment of the initial situation in terms of bone quantity in this dental arch anterior segment is thus very important. Our study aimed to evaluate the reliability of conventional lateral cephalograms to quantify alveolar bone thickness in relation to the maxillary incisors by comparing it with data from CT scans. The second objective was to identify an at risk patient profile by assessing possible correlations between this thickness and dysmorphia components. The results revealed a half of assessment error in the estimation of bone thickness and increased risk in case of hyperdivergence typology, Class III skeletal relationships and dento-alveolar protrusion. Finally, in view of these data, we discussed the clinical procedures to avoid such periodontal failures in this anterior segment of the dental arch. © EDP Sciences, SFODF, 2016.

Seroepidemiology of Sarcocystis neurona and Neospora hughesi infections in domestic donkeys (Equus asinus) in Durango, Mexico.

PubMed

Alvarado-Esquivel, Cosme; Howe, Daniel K; Yeargan, Michelle R; Alvarado-Esquivel, Domingo; Alfredo Zamarripa-Barboza, José; Dubey, Jitender P

2017-01-01

There is currently no information regarding Sarcocystis neurona and Neospora hughesi infections in donkeys in Mexico. Here, we determined the presence of antibodies against S. neurona and N. hughesi in donkeys in the northern Mexican state of Durango. Serum samples of 239 domestic donkeys (Equus asinus) were assayed for S. neurona and N. hughesi antibodies using home-made enzyme-linked immunoassays; six (2.5%) of the 239 donkeys tested seropositive for S. neurona. The seroprevalence of S. neurona infection was comparable among donkeys regardless of their origin, health status, or sex. Multivariate analysis showed that seropositivity to S. neurona was associated with increased age (OR = 2.95; 95% CI: 1.11-7.82; p = 0.02). Antibodies to N. hughesi were found in two (0.8%) of the 239 donkeys. Both exposed donkeys were healthy, 3- and 6-year-old females. This is the first evidence of S. neurona and N. hughesi infections in donkeys in Mexico. © C. Alvarado-Esquivel et al., published by EDP Sciences, 2017.

[Cervical vertebrae: Mandibular growth dynamism indicators?].

PubMed

Raberin, Monique; Cozor, Ilinca; Gobert-Jacquart, Stéphanie

2012-03-01

A study of mandibular growth maturation was performed on a population of 103 patients during orthodontic treatment (69 girls and 34 boys) from 11 to 16 years, having initially a Class II skeletal discrepancy. The relationship between wrist maturation indices and the cervical vertebrae maturation was studied by Lamparski classification. Significant correlations were found between Björk stages, MP3=, MP3 cap and MP3 U and respectively Lamparski stages as CVS 2, CVS 3-4 and CVS 5-6. This retrospective longitudinal study identified three mandibular variables at three different maturation stages according to Björk classification and to the six stages of Lamparski classification. The relationships between these different maturation stages and a quantitative mandibular response permit to estimate optimal time for our orthodontic therapy. The results indicate a significant increase in mandibular length between CVS 4 and CVS 5, suggesting the persistence of a condylar response to a stimulation therapy after CVS3 or CVS 4 stages (MP3 cap). Mandibular growth seems to continue after MP3 U stage or CVS 5 stage. © EDP Sciences, SFODF, 2012.

[Relations between extraction of wisdom teeth and temporomandibular disorders: a case/control study].

PubMed

Duval, Florian; Leroux, Agathe; Bertaud, Valérie; Meary, Fleur; Le Padellec, Clément; Refuveille, Laura; Lemaire, Arnaud; Sorel, Olivier; Chauvel-Lebret, Dominique

2015-09-01

The aim of this study was to assess the impact of extraction of third molars on the occurrence of temporo-mandibular disorders (TMD). A review of the literature and a case-control study have been conducted. The case-control study compares the frequency of extraction of third molars between the sample with TMD (case) and the sample without TMD (control). The proportion of patients who had undergone extractions of wisdom teeth was higher in the case group than in the control group. The difference was statistically significant when patients had undergone extraction of all four wisdom teeth or when the extraction of four wisdom teeth underwent in one sitting or under general anesthesia. The study of patients in case sample shows that all signs of TMD were more common in patients who had undergone extractions in several sessions and under local anesthesia. The temporomandibular joint sounds are significantly more frequent with local anesthesia. In the case group, 85 to 92% of patients have parafunctions and 5 to 11% have malocclusion. This demonstrates the multifactorial etiology of temporomandibular disorders. © EDP Sciences, SFODF, 2015.

A review of data on laboratory colonies of bed bugs (Cimicidae), an insect of emerging medical relevance.

PubMed

Cannet, Arnaud; Akhoundi, Mohammad; Berenger, Jean-Michel; Michel, Gregory; Marty, Pierre; Delaunay, Pascal

2015-01-01

Cimicidae are hematophagous Heteroptera, feeding on human blood, that have been the subject of significant medical investigation. In particular, they have been colonized under laboratory conditions to study their medical relevance. Laboratory colonization of these bugs is a multifactorial phenomenon. Our goal was to conduct a comparative literature review to classify the published data, demonstrating preferred bed bug colony conditions. We show that physical factors including temperature, relative humidity and photoperiod, and physiological factors such as type and frequency of blood meals play important roles in laboratory colonies. Any change in these factors produces changes in life-cycle duration. Temperature and blood meal are the most important factors, with a marked impact on the life-cycle of laboratory populations, depending on the species. A wide range of temperatures (15-34 °C) and relative humidity (46-75%) with an average of 25 °C and 59% were found for these colonies. Two widely used blood sources for the colonies were rabbits and humans. © A. Cannet et al., published by EDP Sciences, 2015.

The effects of climate factors on scabies. A 14-year population-based study in Taiwan.

PubMed

Liu, Jui-Ming; Wang, Hsiao-Wei; Chang, Fung-Wei; Liu, Yueh-Ping; Chiu, Feng-Hsiang; Lin, Yi-Chun; Cheng, Kuan-Chen; Hsu, Ren-Jun

2016-01-01

Scabies is a common infectious disease and can cause severe outbreaks if not controlled quickly. Besides personal contact history, environmental factors are also important. This study analyzed the effects of environmental climate factors on the incidence of scabies in Taiwan. We conducted a 14-year nationwide population-based study: a total of 14,883 patients with scabies infestation were enrolled. Monthly climate data were collected from Taiwan's Central Weather Bureau, including data on temperature, relative humidity, total rainfall, total rain days, and total sunshine hours. The linear relationships between these climate factors and scabies infestations or other risk factors were examined by Pearson's correlation analysis. Overall, the incidence of scabies was negatively correlated with temperature (γ = -0.152, p < 0.001), while being positively correlated with humidity (γ = 0.192, p < 0.001). This useful information may provide evidence for lowering humidity at nursing facilities, hospitals, and military camps with scabies infestations, which may help to reduce its spread and prevent outbreaks. © J.-M. Liu et al., published by EDP Sciences, 2016.

Trypanosoma (Megatrypanum) lainsoni n. sp. from Mesomys hispidus (Rodentia: Echimyidae) in Brazil: trypomastigotes described from experimentally infected laboratory mice.

PubMed

Naiff, Roberto Daibes; Barrett, Toby Vincent

2013-01-01

We report the detection, isolation and description of Trypanosoma (Megatrypanum) lainsoni n. sp. from a caviomorph rodent, Mesomys hispidus (Rodentia: Echimyidae), obtained in the Rio Negro region of the state of Amazonas, in northern Brazil. Laboratory-bred white mice (Mus musculus) and rats (Rattus rattus) were inoculated with large numbers of culture forms by intraperitoneal route, and trypomastigotes appeared in their blood 3-8 days post-inoculation. One single epimastigote was also found in Mus musculus. Similar attempts to infect Rattus norvegicus, hamsters (Mesocricetus auratus), the opossum Didelphis marsupialis, the anteater Tamandua tetradactyla and triatomine bugs were unsuccessful, following six months of observations and microscopic examinations of blood films and blood cultures. As we have found no previous record of a Trypanosoma (Megatrypanum) species naturally infecting a member of the family Echimyidae, or any other caviomorph rodent, we conclude that this is the first time such an infection has been reported. The new species is unusual in the subgenus for its infectivity to laboratory mice. © R.D. Naiff et al., published by EDP Sciences, 2013.

[The birth of Edgewise or the last and best Angle's mechanisms].

PubMed

Philippe, Julien

2016-09-01

Mechanical forces applied to the teeth constitute a not-insignificant feature of orthodontic treatment. Edgewise, the most commonly used type of mechanics, was introduced 88 years ago and has become a standard worldwide. The invention of Edgewise by E.H. Angle in 1928 is an event in the history of orthodontics which deserves to be recalled. Starting with the initial search for this method and leading up to a presentation of the technique itself, this paper provides an overview of the history of Angle mechanics. In order to demonstrate the first mechanical system to function in the three planes of space, Angle provided precise diagrams and instructions for use while insisting, on several occasions, that his mechanics was not complicated and that careful study should allow users to overcome any potential difficulties. The mechanism as devised by Angle, who died shortly after launching his invention, was only used for a short length of time. However, all subsequently invented therapeutic techniques incorporated the mechanical principles underpinning Edgewise, paying tribute in this way to a great invention. © EDP Sciences, SFODF, 2016.

Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia.

PubMed

Wasfi, Fares; Dowall, Stuart; Ghabbari, Tayssir; Bosworth, Andrew; Chakroun, Mohamed; Varghese, Anitha; Tiouiri, Hanene; Ben Jemaa, Mounir; Znazen, Abir; Hewson, Roger; Zhioua, Elyes; Letaief, Amel

2016-01-01

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease associated with a high case fatality rate and transmitted mainly by Hyalomma marginatum. The geographical distribution of H. marginatum covers most of the Western Mediterranean basin. We aimed to investigate whether CCHF virus (CCHFv) is circulating in Tunisia. Samples from unexplained acute febrile patients (n = 181) and a high risk group of humans, mainly slaughter workers (n = 38), were collected in the summer of 2014 and analyzed for exposure to CCHFv using serological tests and real-time RT-PCR. Ticks were collected from Northern and Southern Tunisia during May-June 2014 and examined for the presence of CCHFv by real-time RT-PCR. Of the 181 febrile patients, 5 showed only high titers of IgM suggesting a recent exposure to CCHFv. Among 38 slaughter workers, 2 had IgG anti-CCHFv responses yielding a seroprevalence of 5.2%. No CCHFv was detected in ticks and sera. Our results provide evidence of human exposure to CCHFv in Tunisia. © F. Wasfi et al., published by EDP Sciences, 2016.

Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross.

PubMed

Buckwalter, M S; Katz, R W; Camper, S A

1991-07-01

Ames dwarf (df) is an autosomal recessive mutation characterized by severe dwarfism and infertility. This mutation provides a mouse model for panhypopituitarism. The dwarf phenotype results from failure in the differentiation of the cells which produce growth hormone, prolactin, and thyroid stimulating hormone. Using the backcross (DF/B-df/df X CASA/Rk) X DF/B-df/df, we confirmed the assignment of df to mouse chromosome 11 and demonstrated recombination between df and the growth hormone gene. This backcross is an invaluable resource for screening candidate genes for the df mutation. The df locus maps to less than 1 cM distal to Pad-1 (0.85 +/- 0.85 cM). Two new genes localized on mouse chromosome 11, Rpo2-1, and Edp-1, map to a region of conserved synteny with human chromosome 17. The localization of the alpha 1 adrenergic receptor, Adra-1, extends a known region of synteny conservation between mouse chromosome 11 and human chromosome 5, and suggests that a human counterpart to df would map to human chromosome 5.

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

Influence of elastin-derived peptides, glucose, LDL and oxLDL on nitric oxide synthase expression in human umbilical artery endothelial cells.

PubMed

Garczorz, Wojciech; Francuz, Tomasz; Gmiński, Jan; Likus, Wirginia; Siemianowicz, Krzysztof; Jurczak, Teresa; Strzałka-Mrozik, Barbara

2011-01-01

Endothelial dysfunction plays an important role in the development of atherosclerosis. Elastin-derived peptides (EDP), hyperglycemia, hypercholesterolemia and oxidized LDL have a proven proatherosclerotic potential. Nitric oxide generated by endothelial nitric oxide synthase (eNOS; EC 1.14.13.39) is an important vasorelaxant. Here we studied the influence of those proatherosclerotic factors on eNOS gene and protein expression in artery-derived endothelial cells. Human umbilical artery endothelial cells (HUAEC) were incubated with or without: glucose (270 mg/dl), LDL (200 mg/dl), oxidized LDL (oxLDL 25 mg/dl) or κ-elastin (0.5 and 2.5 µg/ml). Gene expression was assessed by real time RT-PCR, whilst the eNOS protein by ELISA. In cells incubated with 2.5 µg/ml of κ-elastin, a 31 % increase of eNOS mRNA expression was observed, but the protein level remained unchanged. OxLDL, LDL and glucose decreased the eNOS protein level by 74 %, 37 % and 29 %, respectively. OxLDL decreased eNOS mRNA by 42 %. LDL non-significantly decreased eNOS mRNA expression. An elevated glucose level did not affect the eNOS mRNA expression. Hyperglycemia and an elevated level of LDL, particularly oxLDL, decreased the level of eNOS protein in endothelial cells. As κ-elastin did not decrease the expression of eNOS gene in HUAEC, the proatherogenic properties of elastin-derived peptides are unlikely to be due to their influence on eNOS.

Epidemiological survey of ticks and tick-borne pathogens in pet dogs in south-eastern China.

PubMed

Zhang, Jianwei; Liu, Qingbiao; Wang, Demou; Li, Wanmeng; Beugnet, Frédéric; Zhou, Jinlin

2017-01-01

To understand the epidemiology of tick infestation and tick-borne diseases in pet dogs in south-eastern China and to develop a reference for their prevention and treatment, we collected 1550 ticks parasitizing 562 dogs in 122 veterinary clinics from 20 cities of south-eastern China. Dogs were tested for common tick-borne pathogens; collected ticks were identified and processed for the detection of tick-borne pathogens. The use of an in vitro ELISA diagnostic kit for antibody detection (SNAP®4Dx® Plus) on dog sera found the infection rates with Borrelia burgdorferi sensu lato, Ehrlichia canis, and Anaplasma spp. to be 0.4%, 1.3% and 2.7%, respectively. By using a specific ELISA method, the infection rate with Babesia gibsoni was 3.9%. Rhipicephalus sanguineus sensu lato, Haemaphysalis longicornis and Rhipicephalus haemaphysaloides were the major tick species identified on pet dogs. PCR tests were conducted to detect five tick-borne pathogens in 617 ticks. The infection rate was 10.2% for E. canis, 3.4% for Anaplasma platys, 2.3% for B. gibsoni, 0.3% for B. burgdorferi s.l. and 0% for Babesia canis. Some ticks were co-infected with two (1.46%) or three pathogens (0.16%). These results indicate the infestation of pet dogs by ticks infected with tick-borne pathogens in south-eastern China, and the need for effective treatment and routine prevention of tick infestations in dogs. © J. Zhang et al., published by EDP Sciences, 2017.

Emerging and re-emerging viruses of the honey bee (Apis mellifera L.).

PubMed

Genersch, Elke; Aubert, Michel

2010-01-01

Until the late 1980s, specific viral infections of the honey bee were generally considered harmless in all countries. Then, with the worldwide introduction of the ectoparasite mite Varroa destructor, beekeepers encountered increasing difficulties in maintaining their colonies. Epidemiological surveys and laboratory experiments have demonstrated that the newly acquired virulence of several viruses belonging to the family Dicistroviridae (acute bee paralysis virus, Kashmir bee virus and Israeli acute paralysis virus) in Europe and the USA had been observed in relation with V. destructor acting as a disseminator of these viruses between and within bee colonies and as an activator of virus multiplication in the infected individuals: bee larvae and adults. Equal emphasis is given to deformed wing virus (DWV) belonging to the Iflaviridae. Overt outbreaks of DWV infections have been shown to be linked to the ability of V. destructor to act not only as a mechanical vector of DWV but also as a biological vector. Its replication in mites prior to its vectoring into pupae seemed to be necessary and sufficient for the induction of a overt infection in pupae developing in non-viable bees with deformed wings. DWV in V. destructor infested colonies is now considered as one of the key players of the final collapse. Various approaches for combating bee viral diseases are described: they include selection of tolerant bees, RNA interference and prevention of new pathogen introduction. None of these approaches are expected to lead to enhanced bee-health in the short term. © INRA, EDP Sciences, 2010.

Using existing data to predict and quantify the risks of GM forage to a population of a non-target invertebrate species: a New Zealand case study.

PubMed

O'Callaghan, Maureen; Soboleva, Tanya K; Barratt, Barbara I P

2010-01-01

Determining the effects of genetically modified (GM) crops on non-target organisms is essential as many non-target species provide important ecological functions. However, it is simply not possible to collect field data on more than a few potential non-target species present in the receiving environment of a GM crop. While risk assessment must be rigorous, new approaches are necessary to improve the efficiency of the process. Utilisation of published information and existing data on the phenology and population dynamics of test species in the field can be combined with limited amounts of experimental biosafety data to predict possible outcomes on species persistence. This paper presents an example of an approach where data from laboratory experiments and field studies on phenology are combined using predictive modelling. Using the New Zealand native weevil species Nicaeana cervina as a case study, we could predict that oviposition rates of the weevil feeding on a GM ryegrass could be reduced by up to 30% without threat to populations of the weevil in pastoral ecosystems. In addition, an experimentally established correlation between feeding level and oviposition led to the prediction that a consistent reduction in feeding of 50% or higher indicated a significant risk to the species and could potentially lead to local extinctions. This approach to biosafety risk assessment, maximising the use of pre-existing field and laboratory data on non-target species, can make an important contribution to informed decision-making by regulatory authorities and developers of new technologies. © ISBR, EDP Sciences, 2011.

7 CFR 1924.5 - Planning development work.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Planning development work. 1924.5 Section 1924.5... Planning development work. (a) Extent of development. For an FO loan, the plans for development will... for development work. The total cash cost of all planned development will be shown on Form FmHA or its...

Guidelines for Analysis of Health Facilities Planning in Developing Countries. Volume 5: Health Facilities Planning. International Health Planning Methods Series.

ERIC Educational Resources Information Center

Porter, Dennis R.; And Others

Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this fifth of ten manuals in the International Health Planning Methods Series deals with health facilities planning in developing countries. While several specific…

Bidirectional psychoneuroimmune interactions in the early postpartum period influence risk of postpartum depression.

PubMed

Corwin, Elizabeth J; Pajer, Kathleen; Paul, Sudeshna; Lowe, Nancy; Weber, Mary; McCarthy, Donna O

2015-10-01

More than 500,000 U.S. women develop postpartum depression (PPD) annually. Although psychosocial risks are known, the underlying biology remains unclear. Dysregulation of the immune inflammatory response and the hypothalamic-pituitary-adrenal (HPA) axis are associated with depression in other populations. While significant research on the contribution of these systems to the development of PPD has been conducted, results have been inconclusive. This is partly because few studies have focused on whether disruption in the bidirectional and dynamic interaction between the inflammatory response and the HPA axis together influence PPD. In this study, we tested the hypothesis that disruption in the inflammatory-HPA axis bidirectional relationship would increase the risk of PPD. Plasma pro- and anti-inflammatory cytokines were measured in women during the 3rd trimester of pregnancy and on Days 7 and 14, and Months 1, 2, 3, and 6 after childbirth. Saliva was collected 5 times the day preceding blood draws for determination of cortisol area under the curve (AUC) and depressive symptoms were measured using the Edinburgh Postpartum Depression Survey (EPDS). Of the 152 women who completed the EPDS, 18% were depressed according to EDPS criteria within the 6months postpartum. Cortisol AUC was higher in symptomatic women on Day 14 (p=.017). To consider the combined effects of cytokines and cortisol on predicting symptoms of PPD, a multiple logistic regression model was developed that included predictors identified in bivariate analyses to have an effect on depressive symptoms. Results indicated that family history of depression, day 14 cortisol AUC, and the day 14 IL8/IL10 ratio were significant predictors of PPD symptoms. One unit increase each in the IL8/IL10 ratio and cortisol AUC resulted in 1.50 (p=0.06) and 2.16 (p=0.02) fold increases respectively in the development of PPD. Overall, this model correctly classified 84.2% of individuals in their respective groups. Findings suggest that variability in the complex interaction between the inflammatory response and the HPA axis influence the risk of PPD. Copyright © 2015 Elsevier Inc. All rights reserved.

24 CFR 570.205 - Eligible planning, urban environmental design and policy-planning-management-capacity building...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Eligible planning, urban... ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT..., urban environmental design and policy-planning-management-capacity building activities. (a) Planning...

Guidelines for Analysis of Communicable Disease Control Planning in Developing Countries. Volume 1: Communicable Diseases Control Planning. International Health Planning Methods Series.

ERIC Educational Resources Information Center

Chin, James

Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this first of ten manuals in the International Health Planning Methods Series deals with planning and evaluation of communicable disease control programs. The first…

Guidelines for Analysis of Environmental Health Planning in Developing Countries. Volume 2: Environmental Health Planning. International Health Planning Methods Series.

ERIC Educational Resources Information Center

Fraser, Renee White; Shani, Hadasa

Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this second of ten manuals in the International Health Planning Methods Series deals with assessment, planning, and evaluation in the field of environmental health.…

Space Station Mission Planning System (MPS) development study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Klus, W. J.

1987-01-01

The basic objective of the Space Station (SS) Mission Planning System (MPS) Development Study was to define a baseline Space Station mission plan and the associated hardware and software requirements for the system. A detailed definition of the Spacelab (SL) payload mission planning process and SL Mission Integration Planning System (MIPS) software was derived. A baseline concept was developed for performing SS manned base payload mission planning, and it was consistent with current Space Station design/operations concepts and philosophies. The SS MPS software requirements were defined. Also, requirements for new software include candidate programs for the application of artificial intelligence techniques to capture and make more effective use of mission planning expertise. A SS MPS Software Development Plan was developed which phases efforts for the development software to implement the SS mission planning concept.

43 CFR 1610.4-2 - Development of planning criteria.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Development of planning criteria. 1610.4-2... Management Planning § 1610.4-2 Development of planning criteria. (a) The Field Manager will prepare criteria to guide development of the resource management plan or revision, to ensure: (1) It is tailored to...

Teacher Performance Assessment Instruments: Plans for Practice Rating.

ERIC Educational Resources Information Center

Capie, William; And Others

This manual consists of lesson plans developed to train data collectors in the use of the Teacher Performance Assessment Instruments (TPAI). Each set of plans was designed for one of three purposes. Lesson plans developed for the Teaching Plans and Materials Instrument (TPM) simulate a portfolio prepared by the teacher. One-day plans developed for…

7 CFR 1781.15 - Planning and performing development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Planning and performing development. 1781.15 Section..., DEPARTMENT OF AGRICULTURE (CONTINUED) RESOURCE CONSERVATION AND DEVELOPMENT (RCD) LOANS AND WATERSHED (WS) LOANS AND ADVANCES § 1781.15 Planning and performing development. Planning and performing development...

7 CFR 1781.15 - Planning and performing development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Planning and performing development. 1781.15 Section..., DEPARTMENT OF AGRICULTURE (CONTINUED) RESOURCE CONSERVATION AND DEVELOPMENT (RCD) LOANS AND WATERSHED (WS) LOANS AND ADVANCES § 1781.15 Planning and performing development. Planning and performing development...

78 FR 57450 - State Rail Plan Guidance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-18

... development of State rail plans, as appropriate. A commenter recommended that the FRA Regional Manager be... integration of State rail plan development within the statewide/nonmetropolitan transportation planning... Guidance is to describe the processes for the development, submission, and acceptance of State rail plans...

National Data Program for the Marine Environment Technical Development Plan. Final Report, Volume Two.

ERIC Educational Resources Information Center

System Development Corp., Santa Monica, CA.

A national data program for the marine environment is recommended. Volume 2 includes: (1) objectives, scope, and methodology; (2) summary of the technical development plan; (3) agency development plans - Great Lakes and coastal development and (4) marine data network development plans. (Author)

24 CFR 972.230 - Conversion plan components.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Conversion plan components. 972.230... DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Voluntary Conversion of Public Housing Developments Conversion Plans § 972.230 Conversion plan components. A conversion plan must: (a) Describe the...

24 CFR 972.230 - Conversion plan components.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Conversion plan components. 972.230... DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Voluntary Conversion of Public Housing Developments Conversion Plans § 972.230 Conversion plan components. A conversion plan must: (a) Describe the...

The National Plan for Research and Development In Support of Critical Infrastructure Protection

DTIC Science & Technology

2004-01-01

vulnerabilities and highlight areas for improvement. As part of this effort, CIP &CP has cre- ated a research and development agenda aimed at improving...Infrastructure Protection Research and Development Plan 13 LONG-TERM DIRECTION PROVIDED BY THE CIP R&D PLAN The creation of a national critical...Research and Development Plan 20 Mapping to Other National R&D Plans The many R&D plans outside the direct context of CIP underway within DHS, other

Transfusion service disaster planning.

PubMed

Bundy, K L; Foss, M L; Stubbs, J R

2008-01-01

The Mayo Clinic, in Rochester, Minnesota, recently set forth a directive to develop a Mayo Emergency Incident Command System (MEICS) plan to respond to major disasters. The MEICS plan that was developed interfaces with national response plans to ensure effective communication and coordination between our institution and local, state, and federal agencies to establish a common language and communication structure. The MEICS plan addresses multiple aspects of dealing with resource needs during a crisis, including the need for blood and transfusion medicine services. The MEICS plan was developed to supplement our current local emergency preparedness procedures and provide a mechanism for responding to the escalating severity of an emergency to deal with situations of a magnitude that is outside the normal experience. A plan was developed to interface the existing Transfusion Medicine disaster plan standard operating procedures (SOP) with the institutional and Department of Laboratory Medicine (DLMP) MEICS plans. The first step in developing this interface was defining MEICS. Other major steps were defining the chain of command, developing a method for visually indicating who is "in charge," planning communication, defining the actions to be taken, assessing resource needs, developing flowcharts and updating SOPs, and developing a blood rationing team to deal with anticipated blood shortages. Several key features of the interface and updated disaster plan that were developed are calling trees for response personnel, plans for relocating leadership to alternative command centers, and action sheets to assist with resource assessment. The action sheets also provide documentation of key actions by response personnel.

Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression.

PubMed

Escotte-Binet, Sandie; Huguenin, Antoine; Aubert, Dominique; Martin, Anne-Pascaline; Kaltenbach, Matthieu; Florent, Isabelle; Villena, Isabelle

2018-01-01

Metallopeptidases are a family of proteins with domains that remain highly conserved throughout evolution. These hydrolases require divalent metal cation(s) to activate the water molecule in order to carry out their catalytic action on peptide bonds by nucleophilic attack. Metallopeptidases from parasitic protozoa, including Toxoplasma, are investigated because of their crucial role in parasite biology. In the present study, we screened the T. gondii database using PFAM motifs specific for metallopeptidases in association with the MEROPS peptidase Database (release 10.0). In all, 49 genes encoding proteins with metallopeptidase signatures were identified in the Toxoplasma genome. An Interpro Search enabled us to uncover their domain/motif organization, and orthologs with the highest similarity by BLAST were used for annotation. These 49 Toxoplasma metallopeptidases clustered into 15 families described in the MEROPS database. Experimental expression analysis of their genes in the tachyzoite stage revealed transcription for all genes studied. Further research on the role of these peptidases should increase our knowledge of basic Toxoplasma biology and provide opportunities to identify novel therapeutic targets. This type of study would also open a path towards the comparative biology of apicomplexans. © S. Escotte-Binet et al., published by EDP Sciences, 2018.

[Autotransplantation of a maxillary incisor and orthodontic care: a case study].

PubMed

Charpentier, Valentine; Makaremi, Masrour; Brondeau, François de

2017-12-01

Severely impacted teeth with atypical root anatomy do not respond well to orthodontic traction after surgical exposure. Consequently, they are often removed, but replacing them with dental prostheses can prove difficult in patients who are still growing. Thus, autotransplantation seems to be the only way to preserve a natural tooth and the alveolar bone. An upper central incisor impacted in the region of the nasal cavities with an open apex was diagnosed in an 8.5-year-old female patient. The tooth displayed a curved root pressed against the maxillary cortical bone preventing orthodontic traction treatment. Through this clinical case involving autotransplantation of a maxillary incisor report and a review of the literature, this article explores the indications and exposes the different stages of this orthodontic-surgical protocol. In this case, autotransplantation enabled restoration of maxillary arch continuity. After two years of orthodontic treatment, the bone reconstruction of the extraction site was very satisfactory. The benefits of this technique and the precautions to be taken are discussed as well as the various protocols. The increasing success rate of this surgical procedure makes it possible to consider it as a protocol for the future. © EDP Sciences, SFODF, 2017.

Efficiency of colored modified box traps for sampling of tabanids.

PubMed

Krčmar, Stjepan; Radolić, Vanja; Lajoš, Petar; Lukačević, Igor

2014-01-01

The efficiency of ten differently colored modified box traps for collecting tabanids was studied in the Monjoroš Forest in eastern Croatia. A total of 5,436 specimens belonging to 16 species of tabanids grouped into six genera were collected. The genus Tabanus was the most represented with 98% of all collected tabanids. Tabanus bromius comprised 90% of tabanids collected, and was the most abundant species collected in all box traps. The majority of tabanids (74%) were collected from black, brown, bordeaux, red, and blue traps (dark group), whereas 26% were collected from green, light violet, white, orange, and yellow traps (light group). The black modified trap was the most successful and collected 20% of all collected tabanids, whereas the yellow trap was the least effective with 1%. The number of collected specimens of species T. bromius differed significantly between the dark and light group of traps. Traps with lower reflectance from green color collected 77% of T. bromius. The most species of tabanids (12) was collected in the brown trap, whereas the least number of species (6) was collected in the yellow trap. © S. Krčmar et al., published by EDP Sciences, 2014.

[Effectiveness of selective alveolar decortication in accelerating orthodontic treatment: a systematic review].

PubMed

Fau, Victor; Diep, Dany; Bader, Gérard; Brézulier, Damien; Sorel, Olivier

2017-06-01

The number of scientific publications on accelerating orthodontic treatment, and especially surgical alveolar corticotomies techniques, has grown exponentially over the years. The objective of this systematic literature review was to assess the effectiveness of these corticotomies basing on human studies. The review was conducted from Medline and Web of Science Core Collection to identify prospective controlled clinical trials with duration of orthodontic treatment or the tooth movement rate for primary endpoint. Eleven studies respected all inclusion criteria. Six investigated the duration of treatment and found shorter values in experimental group than in control group, with a gain of 8 to 34 weeks. Five investigated the tooth movement rate and found 2.3 times higher values on average during the first month in experimental groups, 1.9 times during the second and third months, and 1.3 times during the fourth month. The technique also seemed to decrease the risk of root resorption and improve molar anchorage. Moreover, it exhibited good periodontal tolerance. Current literature highlights the effectiveness of surgical decortications during the first three to four months after surgery. Longer prospective studies are needed to assess their long term effects. © EDP Sciences, SFODF, 2017.

Sarcocystis spp. in domestic sheep in Kunming City, China: prevalence, morphology, and molecular characteristics.

PubMed

Hu, Jun-Jie; Huang, Si; Wen, Tao; Esch, Gerald W; Liang, Yu; Li, Hong-Liang

2017-01-01

Sheep (Ovis aries) are intermediate hosts for at least six named species of Sarcocystis: S. tenella, S. arieticanis, S. gigantea, S. medusiformis, S. mihoensis, and S. microps. Here, only two species, S. tenella and S. arieticanis, were found in 79 of 86 sheep (91.9%) in Kunming, China, based on their morphological characteristics. Four genetic markers, i.e., 18S rRNA gene, 28S rRNA gene, mitochondrial cox1 gene, and ITS-1 region, were sequenced and characterized for the two species of Sarcocystis. Sequences of the three former markers for S. tenella shared high identities with those of S. capracanis in goats, i.e., 99.0%, 98.3%, and 93.6%, respectively; the same three marker sequences of S. arieticanis shared high identities with those of S. hircicanis in goats, i.e., 98.5%, 96.5%, and 92.5%, respectively. No sequences in GenBank were found to significantly resemble the ITS-1 regions of S. tenella and S. arieticanis. Identities of the four genetic markers for S. tenella and S. arieticanis were 96.3%, 95.4%, 82.5%, and 66.2%, respectively. © J.-J. Hu et al., published by EDP Sciences, 2017.

Structural morphology study of Cd2+ induced Langmuir Blodgett multilayer films of arachidic acid

NASA Astrophysics Data System (ADS)

Roy, Dhrubojyoti; Das, Nayan Mani; Gupta, P. S.

2013-04-01

The organization and headgroup co-ordination of Cadmium Arachidate (CdAA) molecule in Langmuir-Blodgett (LB) multilayer films deposited on hydrophilic Glass (SiO2) and Silicon (100) substrate at normal subphase pH (6.8) are studied. X-ray diffraction (XRD) and X-ray reflectivity (XRR) study reveals ordered layer by layer organization with uniform packing of CdAA molecules, and with a small tilt angle of alkyl chain of CdAA molecule equal to 6.8° ± 1.75°. Electron density profiles (EDPs) shows that the coverage of films remains almost constant with increase in bilayer thickness which indicate very little presence of pinhole defects. AFM study for 25 ML shows that coverage of the film remain intact upto 22nd ML and then decreases sharply due to presence of pinhole defects. Fourier transform infrared spectroscopy (FTIR) study is also consistent with XRD and XRR study of ordered deposition of CdAA molecule. FTIR and X-ray photoelectron spectroscopy (XPS) study indicates the formation of unidentate bridging metal-carboxylate coordination type headgroups consistent with one cadmium metal ion between two carboxylate (COO) groups in each headgroup structure.

Human spiruridiasis due to Physaloptera spp. (Nematoda: Physalopteridae) in a grave of the Shahr-e Sukhteh archeological site of the Bronze Age (2800-2500 BC) in Iran.

PubMed

Makki, Mahsasadat; Dupouy-Camet, Jean; Seyed Sajjadi, Seyed Mansour; Moravec, František; Reza Naddaf, Saied; Mobedi, Iraj; Malekafzali, Hossein; Rezaeian, Mostafa; Mohebali, Mehdi; Kargar, Faranak; Mowlavi, Gholamreza

2017-01-01

Evidence of rare human helminthiasis in paleoparasitological records is scarce. we report here the finding of Physaloptera spp. eggs in a soil sample collected in the pelvic and sacrum bones area of a skeleton excavated from a grave of Shahr-e Sukhteh archeological site dating back to the Bronze Age. The site is located in southeastern Iran and has attracted the attention of numerous archeological teams owing to its vast expanse and diverse archeological findings since 1997. The spirurid nematodes Physaloptera spp. are rarely the cause of human helminthiasis nowadays, but this infection might not have been so rare in ancient populations such as those in the Shahr-e Sukhteh. Out of 320 skeletons analyzed in this study, only one parasitized individual was detected. This surprising result led us to suspect the role of nematophagous fungi and other taphonomic processes in possible false-negative results. This is the first paleoparasitological study on human remains in this archeological site and the first record of ancient human physalopterosis in the Middle East. © M. Makki et al., published by EDP Sciences, 2017.

7 CFR 1778.22 - Planning development and procurement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Planning development and procurement. 1778.22 Section 1778.22 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Planning development and procurement. Planning development and procurement for grants made under this part...

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2014 CFR

2014-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan... facilities, and (4) Development of schedules of implementation. (d) The State plan should encourage private...

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2012 CFR

2012-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan... facilities, and (4) Development of schedules of implementation. (d) The State plan should encourage private...

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2013 CFR

2013-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan... facilities, and (4) Development of schedules of implementation. (d) The State plan should encourage private...

24 CFR 572.315 - Rating criteria for planning grants.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Rating criteria for planning grants... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF... (HOPE 3) Selection Process § 572.315 Rating criteria for planning grants. Any planning grants made by...

24 CFR 572.205 - Planning grants-eligible activities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Planning grants-eligible activities... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF... (HOPE 3) Grants § 572.205 Planning grants—eligible activities. Any planning grants made by HUD under the...

76 FR 9044 - Notice of Extension of Information Collection for Public Comment; Consolidated Plan and Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

... the Assistant Secretary for Community Planning and Development, HUD. ACTION: Notice of Extension of... requirements for Consolidated Planning for Community Planning and Development (CPD) programs described below... INFORMATION CONTACT: Salvatore Sclafani, Office of Community Planning & Development, telephone (202) 402-4364...

Payload crew activity planning integration. Task 2: Inflight operations and training for payloads

NASA Technical Reports Server (NTRS)

Hitz, F. R.

1976-01-01

The primary objectives of the Payload Crew Activity Planning Integration task were to: (1) Determine feasible, cost-effective payload crew activity planning integration methods. (2) Develop an implementation plan and guidelines for payload crew activity plan (CAP) integration between the JSC Orbiter planners and the Payload Centers. Subtask objectives and study activities were defined as: (1) Determine Crew Activity Planning Interfaces. (2) Determine Crew Activity Plan Type and Content. (3) Evaluate Automated Scheduling Tools. (4) Develop a draft Implementation Plan for Crew Activity Planning Integration. The basic guidelines were to develop a plan applicable to the Shuttle operations timeframe, utilize existing center resources and expertise as much as possible, and minimize unnecessary data exchange not directly productive in the development of the end-product timelines.

Automating Space Station operations planning

NASA Technical Reports Server (NTRS)

Ziemer, Kathleen A.

1989-01-01

The development and implementation of the operations planning processes for the Space Station are discussed. A three level planning process, consisting of strategic, tactical, and execution level planning, is being developed. The integration of the planning procedures into a tactical planning system is examined and the planning phases are illustrated.

Lessons Learned In Developing Multiple Distributed Planning Systems for the International Space Station

NASA Technical Reports Server (NTRS)

Maxwell, Theresa G.; McNair, Ann R. (Technical Monitor)

2002-01-01

The planning processes for the International Space Station (ISS) Program are quite complex. Detailed mission planning for ISS on-orbit operations is a distributed function. Pieces of the on-orbit plan are developed by multiple planning organizations, located around the world, based on their respective expertise and responsibilities. The "pieces" are then integrated to yield the final detailed plan that will be executed onboard the ISS. Previous space programs have not distributed the planning and scheduling functions to this extent. Major ISS planning organizations are currently located in the United States (at both the NASA Johnson Space Center (JSC) and NASA Marshall Space Flight Center (MSFC)), in Russia, in Europe, and in Japan. Software systems have been developed by each of these planning organizations to support their assigned planning and scheduling functions. Although there is some cooperative development and sharing of key software components, each planning system has been tailored to meet the unique requirements and operational environment of the facility in which it operates. However, all the systems must operate in a coordinated fashion in order to effectively and efficiently produce a single integrated plan of ISS operations, in accordance with the established planning processes. This paper addresses lessons learned during the development of these multiple distributed planning systems, from the perspective of the developer of one of the software systems. The lessons focus on the coordination required to allow the multiple systems to operate together, rather than on the problems associated with the development of any particular system. Included in the paper is a discussion of typical problems faced during the development and coordination process, such as incompatible development schedules, difficulties in defining system interfaces, technical coordination and funding for shared tools, continually evolving planning concepts/requirements, programmatic and budget issues, and external influences. Techniques that mitigated some of these problems will also be addressed, along with recommendations for any future programs involving the development of multiple planning and scheduling systems. Many of these lessons learned are not unique to the area of planning and scheduling systems, so may be applied to other distributed ground systems that must operate in concert to successfully support space mission operations.

Lessons Learned in Developing Multiple Distributed Planning Systems for the International Space Station

NASA Technical Reports Server (NTRS)

Maxwell, Theresa G.

2002-01-01

The planning processes for the International Space Station (ISS) Program are quite complex. Detailed mission planning for ISS on-orbit operations is a distributed function. Pieces of the on-orbit plan are developed by multiple planning organizations, located around the world, based on their respective expertise and responsibilities. The pieces are then integrated to yield the final detailed plan that will be executed onboard the ISS. Previous space programs have not distributed the planning and scheduling functions to this extent. Major ISS planning organizations are currently located in the United States (at both the NASA Johnson Space Center (JSC) and NASA Marshall Space Flight Center (MSFC)), in Russia, in Europe, and in Japan. Software systems have been developed by each of these planning organizations to support their assigned planning and scheduling functions. Although there is some cooperative development and sharing of key software components, each planning system has been tailored to meet the unique requirements and operational environment of the facility in which it operates. However, all the systems must operate in a coordinated fashion in order to effectively and efficiently produce a single integrated plan of ISS operations, in accordance with the established planning processes. This paper addresses lessons learned during the development of these multiple distributed planning systems, from the perspective of the developer of one of the software systems. The lessons focus on the coordination required to allow the multiple systems to operate together, rather than on the problems associated with the development of any particular system. Included in the paper is a discussion of typical problems faced during the development and coordination process, such as incompatible development schedules, difficulties in defining system interfaces, technical coordination and funding for shared tools, continually evolving planning concepts/requirements, programmatic and budget issues, and external influences. Techniques that mitigated some of these problems will also be addressed, along with recommendations for any future programs involving the development of multiple planning and scheduling systems. Many of these lessons learned are not unique to the area of planning and scheduling systems, so may be applied to other distributed ground systems that must operate in concert to successfully support space mission operations.

The Electronic Documentation Project in the NASA mission control center environment

NASA Technical Reports Server (NTRS)

Wang, Lui; Leigh, Albert

1994-01-01

NASA's space programs like many other technical programs of its magnitude is supported by a large volume of technical documents. These documents are not only diverse but also abundant. Management, maintenance, and retrieval of these documents is a challenging problem by itself; but, relating and cross-referencing this wealth of information when it is all on a medium of paper is an even greater challenge. The Electronic Documentation Project (EDP) is to provide an electronic system capable of developing, distributing and controlling changes for crew/ground controller procedures and related documents. There are two primary motives for the solution. The first motive is to reduce the cost of maintaining the current paper based method of operations by replacing paper documents with electronic information storage and retrieval. And, the other is to improve the efficiency and provide enhanced flexibility in document usage. Initially, the current paper based system will be faithfully reproduced in an electronic format to be used in the document viewing system. In addition, this metaphor will have hypertext extensions. Hypertext features support basic functions such as full text searches, key word searches, data retrieval, and traversal between nodes of information as well as speeding up the data access rate. They enable related but separate documents to have relationships, and allow the user to explore information naturally through non-linear link traversals. The basic operational requirements of the document viewing system are to: provide an electronic corollary to the current method of paper based document usage; supplement and ultimately replace paper-based documents; maintain focused toward control center operations such as Flight Data File, Flight Rules and Console Handbook viewing; and be available NASA wide.

[Translation and cultural adaptation of a french version of the psychosocial impact of dental aesthetics questionnaire: PIDAQ].

PubMed

Ngom, Papa Ibrahima; Attebi, Pascaline; Diouf, Joseph Samba; Diop Ba, Khady; Badiane, Alpha; Diagne, Falou

2013-12-01

The Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) is a tool developed and validated to specifically assess subject's quality of life related to orthodontic anomalies. The aims of the present study were to translate and culturally adapt the PIDAQ's native English version into French, and to test the psychometric characteristics of the version thereby obtained. Toward these ends, the PIDAQ's original English version was translated into French and back-translated into English following the prescribed guidelines. Each of the versions obtained from the translation process was further subjected to a committee review. The final French version which is named QIPEO underwent an analysis of psychometric properties on a sample of 42 subjects (33 females and 9 males, aged 24.60 ± 8.66 years). Internal consistency was good with Cronbach ff coefficients ranging from 0.67 for "aesthetic concerns" to 0.87 for "social impact". The reproducibility of the responses given by 14 subjects after 15 days interval was correct with intraclass coefficients ranging from 0.72 for "social impact" to 0.90 for "aesthetic concerns". Furthermore, the different subscales of the French version of the PIDAQ showed excellent correlation with the perception of aesthetics and fairly good correlation with self-perception of orthodontic treatment need. Definite need for orthodontic treatment, as assessed normatively by the IOTN, was significantly associated with lower scores of "self-confidence" and higher scores of "social impact", "psychological impact" and "aesthetic concerns". Overall, the French version of the PIDAQ was shown to be reliable and has some validity for use in this population. Further studies including a larger sample size is recommended to reassess the validation and the responsiveness of this French version. © EDP Sciences, SFODF, 2013.

Comparison of the serological tests ICT and ELISA for the diagnosis of alveolar echinococcosis in France.

PubMed

Knapp, Jenny; Sako, Yasuhito; Grenouillet, Frédéric; Bresson-Hadni, Solange; Richou, Carine; Gbaguidi-Haore, Houssein; Ito, Akira; Millon, Laurence

2014-01-01

Serological diagnosis of alveolar echinococcosis (AE) is a key element for efficient patient treatment management. A rapid immunochromatography test kit (ICT) using the recombinant Em18 antigen (rEm18) was recently developed. The aim of our study was to assess this test on a panel of sera from French patients with alveolar echinococcosis and control patients. In a blind test, a total of 112 serum samples were tested including samples of AE (n = 30), cystic echinococcosis [CE] (n = 15), and polycystic echinococcosis [PE] (n = 1). For the comparison, 66 sera from patients with hepatocarcinoma, fascioliasis, toxocariasis, Caroli's disease, or autoimmune chronic active hepatitis were used. The diagnostic test sets we used were the rEm18-ICT and two validated ELISAs with rEm18 and Em2-Em18 antigens, respectively. For the ICT, 27/30 sera from AE patients, 4/15 sera from CE patients and the PE patient serum were positive. One serum from the control panel (toxocariasis) was positive for the ICT. The rEm18-ICT sensitivity (90.0%) and specificity (92.7%) for detection of Em18-specific antibodies confirmed it as a relevant tool for AE diagnosis. The rEm18-ELISA had a sensitivity of 86.7% and specificity of 91.5%, and the Em2-Em18-ELISA had a sensitivity of 96.7% and specificity of 87.8%. However, when AE patient sera are recorded as weak in intensity with the ICT, we recommend a double reading and use of a reference sample if the ICT is used for patient follow-up. © J. Knapp et al., published by EDP Sciences, 2014.

Modulatory Effect of Association of Brain Stimulation by Light and Binaural Beats in Specific Brain Waves

PubMed Central

Calomeni, Mauricio Rocha; Furtado da Silva, Vernon; Velasques, Bruna Brandão; Feijó, Olavo Guimarães; Bittencourt, Juliana Marques; Ribeiro de Souza e Silva, Alair Pedro

2017-01-01

Introduction: One of the positive effects of brain stimulation is interhemispheric modulation as shown in some scientific studies. This study examined if a type of noninvasive stimulation using binaural beats with led-lights and sound would show different modulatory effects upon Alfa and SMR brain waves of elderlies and children with some disease types. Subjects: The sample included 75 individuals of both genders, being, randomly, divided in 6 groups. Groups were named elderly without dementia diagnosis (EWD), n=15, 76±8 years, elderly diagnosed with Parkinson’s disease (EDP), n=15, 72±7 years, elderly diagnosed with Alzheimer’s disease (EDA), n=15, 81±6 years. The other groups were named children with Autism (CA), n=10, 11±4 years, children with Intellectual Impairment (CII), n=10, 12 ±5 years and children with normal cognitive development (CND), n=10, 11±4 years. Instruments and procedure: Instruments were the Mini Mental State Examination Test (MMSE), EEG-Neurocomputer instrument for brain waves registration, brain stimulator, Digit Span Test and a Protocol for working memory training. Data collection followed a pre and post-conjugated stimulation version. Results: The results of the inferential statistics showed that the stimulation protocol had different effects on Alpha and SMR brain waves of the patients. Also, indicated gains in memory functions, for both, children and elderlies as related to gains in brain waves modulation. Conclusion: The results may receive and provide support to a range of studies examining brain modulation and synaptic plasticity. Also, it was emphasized in the results discussion that there was the possibility of the technique serving as an accessory instrument to alternative brain therapies. PMID:29238390

Modulatory Effect of Association of Brain Stimulation by Light and Binaural Beats in Specific Brain Waves.

PubMed

Calomeni, Mauricio Rocha; Furtado da Silva, Vernon; Velasques, Bruna Brandão; Feijó, Olavo Guimarães; Bittencourt, Juliana Marques; Ribeiro de Souza E Silva, Alair Pedro

2017-01-01

One of the positive effects of brain stimulation is interhemispheric modulation as shown in some scientific studies. This study examined if a type of noninvasive stimulation using binaural beats with led-lights and sound would show different modulatory effects upon Alfa and SMR brain waves of elderlies and children with some disease types. The sample included 75 individuals of both genders, being, randomly, divided in 6 groups. Groups were named elderly without dementia diagnosis (EWD), n=15, 76±8 years, elderly diagnosed with Parkinson's disease (EDP), n=15, 72±7 years, elderly diagnosed with Alzheimer's disease (EDA), n=15, 81±6 years. The other groups were named children with Autism (CA), n=10, 11±4 years, children with Intellectual Impairment (CII), n=10, 12 ±5 years and children with normal cognitive development (CND), n=10, 11±4 years. Instruments were the Mini Mental State Examination Test (MMSE), EEG-Neurocomputer instrument for brain waves registration, brain stimulator, Digit Span Test and a Protocol for working memory training. Data collection followed a pre and post-conjugated stimulation version. The results of the inferential statistics showed that the stimulation protocol had different effects on Alpha and SMR brain waves of the patients. Also, indicated gains in memory functions, for both, children and elderlies as related to gains in brain waves modulation. The results may receive and provide support to a range of studies examining brain modulation and synaptic plasticity. Also, it was emphasized in the results discussion that there was the possibility of the technique serving as an accessory instrument to alternative brain therapies.

Documentation for assessment of modal pushover-based scaling procedure for nonlinear response history analysis of "ordinary standard" bridges

USGS Publications Warehouse

Kalkan, Erol; Kwong, Neal S.

2010-01-01

The earthquake engineering profession is increasingly utilizing nonlinear response history analyses (RHA) to evaluate seismic performance of existing structures and proposed designs of new structures. One of the main ingredients of nonlinear RHA is a set of ground-motion records representing the expected hazard environment for the structure. When recorded motions do not exist (as is the case for the central United States), or when high-intensity records are needed (as is the case for San Francisco and Los Angeles), ground motions from other tectonically similar regions need to be selected and scaled. The modal-pushover-based scaling (MPS) procedure recently was developed to determine scale factors for a small number of records, such that the scaled records provide accurate and efficient estimates of 'true' median structural responses. The adjective 'accurate' refers to the discrepancy between the benchmark responses and those computed from the MPS procedure. The adjective 'efficient' refers to the record-to-record variability of responses. Herein, the accuracy and efficiency of the MPS procedure are evaluated by applying it to four types of existing 'ordinary standard' bridges typical of reinforced-concrete bridge construction in California. These bridges are the single-bent overpass, multi span bridge, curved-bridge, and skew-bridge. As compared to benchmark analyses of unscaled records using a larger catalog of ground motions, it is demonstrated that the MPS procedure provided an accurate estimate of the engineering demand parameters (EDPs) accompanied by significantly reduced record-to-record variability of the responses. Thus, the MPS procedure is a useful tool for scaling ground motions as input to nonlinear RHAs of 'ordinary standard' bridges.

[Preventive and therapeutic advantages of sugar-free chewing gums in orthodontics. A study conducted on practitioners and patients].

PubMed

Ferney, Pauline; Clauss, François; Offner, Damien; Wagner, Delphine

2017-09-01

The objective of this study is to assess the level of knowledge in a cohort of oral health professionals and patients about preventive and therapeutic actions of sugar-free chewing gums. A forward-looking monocentric study of perception regarding the level of information about the effects of sugar-free chewing gums consumption was conducted on 135 young patients, from 11 to 17 years old, carriers of fixed orthodontic appliances and treated in the Department of Orthodontics in the Oral Medicine and Surgery Center of the University Hospitals of Strasbourg. Besides, 34 practitioners in the Department of Orthodontics and Pediatric Dentistry were also included. Data were collected between May 2016 and July 2016. A specific questionnaire, using the adapted terminology and dealing with the same items was developed for each studied population. The majority of the individuals of both studied populations believe that the consumption of sugar-free chewing gum leads to a greater risk of orthodontic device unsticking or fracture and that it is not associated to a decrease of the orthodontic pain. Our results confirm the fact that the knowledge, mainly acquired in an empirical way, is against the data of the current literature. The evaluation of the level of knowledge demonstrated that there is a real lack of information about the preventive interests of the consumption of sugar-free chewing gums during orthodontic treatment. This study highlights the need for information campaigns and oral prevention in general population, as well as in healthcare professionals, concerning the preventive and analgesic interests of sugar-free chewing gums during orthodontic treatments. © EDP Sciences, SFODF, 2017.

Contingency plan implementation.

PubMed

Neurath, D; Cober, N; Owens, W; Giulivi, A

2012-06-01

Although the National blood system in Canada reduces the risk of inventory shortages the possibility of a blood supply shortage still exists. The Ontario Ministry of Health and Long-Term Care developed a provincial plan to manage blood transfusion needs and inventory in the event of a National blood shortage. The Ontario plan was developed to align with the National plan as well as other provincial plans in order to ensure consistency in blood management strategies across the country. The Ontario plan was released in 2008, along with a toolkit to aid hospitals in developing their facility specific plans. In the Champlain region of Ontario, a group of 16 hospitals worked collaboratively to develop a regional blood shortage plan. A provincial blood shortage simulation exercise was held in 2010 to test out these plans. The Director of Transfusion Medicine of the largest facility in the group of 16 hospitals (The Ottawa Hospital) took the lead in the development of the regional blood shortage management plan. Working groups from all 16 sites contributed to the plan development. The proposed plan was presented to the Medical Advisory Committee for approval. The plan consists of activities relating to the severity of the supply shortage as defined by Amber, Red, Recovery and Green phases. The plan includes a communication plan for notifying stakeholders including patients whose treatment may be affected. Inventory management and triage guidelines are provided to reduce the demand for blood and to conserve inventory for those patients whose need is prioritized as highest. The regional blood shortage management plan was tested successfully during the provincial simulation exercise. Where regional hospitals work together to provide healthcare, it is beneficial to develop a standardized plan to provide guidance to hospital personnel in response to a blood supply shortage. A consistent plan will ensure patient care is provided in a consistent manner across a health region. Mock or simulation exercises can aid in testing plans and raising the awareness of stakeholders. Copyright © 2012 Elsevier Ltd. All rights reserved.

78 FR 18674 - Invitation for Public Comment on Draft DOT Research, Development and Technology Strategic Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

...-0002] Invitation for Public Comment on Draft DOT Research, Development and Technology Strategic Plan... for public comment on its draft strategic plan, U.S. Department of Transportation, Research, Development and Technology Strategic Plan FY 2013-2018. The new five-year strategic plan will guide the...

42 CFR 417.920 - Planning and initial development.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Planning and initial development. 417.920 Section... and initial development. (a) Under section 1304 of the PHS Act, grants and loan guarantees were awarded for projects for planning and initial development of HMOs. (b) Planning projects included projects...

24 CFR 972.130 - Conversion plan components.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Conversion plan components. 972.130... DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Required Conversion of Public Housing Developments Conversion Plans § 972.130 Conversion plan components. (a) With respect to any development that is...

24 CFR 972.130 - Conversion plan components.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Conversion plan components. 972.130... DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Required Conversion of Public Housing Developments Conversion Plans § 972.130 Conversion plan components. (a) With respect to any development that is...

34 CFR 200.27 - Development of a schoolwide program plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Development of a schoolwide program plan. (a)(1) A school operating a schoolwide program must develop a comprehensive plan to improve teaching and learning throughout the school. (2) The school must develop the comprehensive plan in consultation with the LEA and its school support team or other technical assistance...

34 CFR 200.27 - Development of a schoolwide program plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Development of a schoolwide program plan. (a)(1) A school operating a schoolwide program must develop a comprehensive plan to improve teaching and learning throughout the school. (2) The school must develop the comprehensive plan in consultation with the LEA and its school support team or other technical assistance...

34 CFR 200.27 - Development of a schoolwide program plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Development of a schoolwide program plan. (a)(1) A school operating a schoolwide program must develop a comprehensive plan to improve teaching and learning throughout the school. (2) The school must develop the comprehensive plan in consultation with the LEA and its school support team or other technical assistance...

34 CFR 200.27 - Development of a schoolwide program plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Development of a schoolwide program plan. (a)(1) A school operating a schoolwide program must develop a comprehensive plan to improve teaching and learning throughout the school. (2) The school must develop the comprehensive plan in consultation with the LEA and its school support team or other technical assistance...

7 CFR 625.12 - The HFRP restoration plan development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false The HFRP restoration plan development. 625.12 Section... CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.12 The HFRP restoration plan development. (a) The development of the HFRP restoration plan shall be made...

Adaptive Planning: Understanding Organizational Workload to Capability/ Capacity through Modeling and Simulation

NASA Technical Reports Server (NTRS)

Hase, Chris

2010-01-01

In August 2003, the Secretary of Defense (SECDEF) established the Adaptive Planning (AP) initiative [1] with an objective of reducing the time necessary to develop and revise Combatant Commander (COCOM) contingency plans and increase SECDEF plan visibility. In addition to reducing the traditional plan development timeline from twenty-four months to less than twelve months (with a goal of six months)[2], AP increased plan visibility to Department of Defense (DoD) leadership through In-Progress Reviews (IPRs). The IPR process, as well as the increased number of campaign and contingency plans COCOMs had to develop, increased the workload while the number of planners remained fixed. Several efforts from collaborative planning tools to streamlined processes were initiated to compensate for the increased workload enabling COCOMS to better meet shorter planning timelines. This paper examines the Joint Strategic Capabilities Plan (JSCP) directed contingency planning and staffing requirements assigned to a combatant commander staff through the lens of modeling and simulation. The dynamics of developing a COCOM plan are captured with an ExtendSim [3] simulation. The resulting analysis provides a quantifiable means by which to measure a combatant commander staffs workload associated with development and staffing JSCP [4] directed contingency plans with COCOM capability/capacity. Modeling and simulation bring significant opportunities in measuring the sensitivity of key variables in the assessment of workload to capability/capacity analysis. Gaining an understanding of the relationship between plan complexity, number of plans, planning processes, and number of planners with time required for plan development provides valuable information to DoD leadership. Through modeling and simulation AP leadership can gain greater insight in making key decisions on knowing where to best allocate scarce resources in an effort to meet DoD planning objectives.

Planning for transit-supportive development : a practitioner's guide. Section 2 : general transit-supportive development planning topics.

DOT National Transportation Integrated Search

2014-06-01

Planning for Transit-Supportive Development: A Practitioners Guide is a toolkit of practical and innovative measures to help : Metropolitan Planning Organizations (MPOs), regional planners, transit agencies, and local government elected o...

Planning for transit-supportive development : a practitioner's guide. Section 5 : local planning and transit-supportive development.

DOT National Transportation Integrated Search

2014-06-01

Planning for Transit-Supportive Development: A Practitioners Guide is a toolkit of practical and innovative measures to help : Metropolitan Planning Organizations (MPOs), regional planners, transit agencies, and local government elected o...

Planning for transit-supportive development : a practitioner's guide. Section 4 : corridor planning and transit-supportive development.

DOT National Transportation Integrated Search

2014-06-01

Planning for Transit-Supportive Development: A Practitioners Guide is a toolkit of practical and innovative measures to help : Metropolitan Planning Organizations (MPOs), regional planners, transit agencies, and local government elected o...

24 CFR 984.201 - Action Plan.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Action Plan. 984.201 Section 984... § 984.201 Action Plan. (a) Requirement for Action Plan. A PHA must have a HUD-approved Action Plan that... program is a mandatory or voluntary program. (b) Development of Action Plan. The Action Plan shall be...

24 CFR 984.201 - Action Plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Action Plan. 984.201 Section 984... § 984.201 Action Plan. (a) Requirement for Action Plan. A PHA must have a HUD-approved Action Plan that... program is a mandatory or voluntary program. (b) Development of Action Plan. The Action Plan shall be...

Planning to Serve: Using Backwards Planning to Design Service-Learning Lesson Plans in the Preservice Curriculum

ERIC Educational Resources Information Center

Stiler, Gary

2009-01-01

The author describes how the Understanding by Design (backwards planning) lesson plan format was used by his preservice K-12 students to develop service-learning lesson plans. Preservice teachers in a multicultural education course were given an assignment to develop service-learning lesson plans using the Understanding by Design planning process.…

Planning for transit-supportive development : a practitioner's guide. Section 3 : regional vision planning and transit-supportive development.

DOT National Transportation Integrated Search

2014-06-01

Planning for Transit-Supportive Development: A Practitioners Guide is a toolkit of practical and innovative measures to help : Metropolitan Planning Organizations (MPOs), regional planners, transit agencies, and local government elected o...

43 CFR 3183.6 - Plan of development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Plan of development. 3183.6 Section 3183.6... Filing and Approval of Documents § 3183.6 Plan of development. Three counterparts of all plans of development and operation shall be submitted for approval under an approved agreement. [48 FR 26766, June 10...

25 CFR 115.419 - Who develops a minor's distribution plan?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Who develops a minor's distribution plan? 115.419 Section... FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Minors § 115.419 Who develops a minor's distribution plan? A social service provider will develop a minor's distribution plan for approval by the BIA after...

25 CFR 115.419 - Who develops a minor's distribution plan?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Who develops a minor's distribution plan? 115.419 Section... FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Minors § 115.419 Who develops a minor's distribution plan? A social service provider will develop a minor's distribution plan for approval by the BIA after...

The 30/20 GHz flight experiment system, phase 2. Volume 4: Experiment system development plan

NASA Technical Reports Server (NTRS)

Bronstein, L.; Kawamoto, Y.; Riberich, J. J.; Scope, J. R.; Forman, B. J.; Bergman, S. G.; Reisenfeld, S.

1981-01-01

The development plan for the 30/20 GHz flight experiment system is presented. A master program schedule with detailed development plans for each subsystem is planned with careful attention given to how technology items to ensure a minimal risk. The work breakdown structure shows the organization of the program management with detailed task definitions. The ROM costs based on the development plan are also given.

14 CFR 151.111 - Advance planning proposals: General.

Code of Federal Regulations, 2013 CFR

2013-01-01

... airport layout plan, under § 151.5(a), or the development of plans designed to lead to a project... proposal must relate to an airport layout plan or plans and specifications for the development of a new...

14 CFR 151.111 - Advance planning proposals: General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... airport layout plan, under § 151.5(a), or the development of plans designed to lead to a project... proposal must relate to an airport layout plan or plans and specifications for the development of a new...

14 CFR 151.111 - Advance planning proposals: General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... airport layout plan, under § 151.5(a), or the development of plans designed to lead to a project... proposal must relate to an airport layout plan or plans and specifications for the development of a new...

14 CFR 151.111 - Advance planning proposals: General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... airport layout plan, under § 151.5(a), or the development of plans designed to lead to a project... proposal must relate to an airport layout plan or plans and specifications for the development of a new...

Guidelines for Analysis of Health Manpower Planning. Volume 3: Health Manpower Planning. International Health Planning Methods Series.

ERIC Educational Resources Information Center

Staff, Robert J.; Porter, Dennis R.

Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this third of ten manuals in the International Health Planning Methods Series deals with health manpower planning and assessment. It provides a conceptual and…

Influences of different land use spatial control schemes on farmland conversion and urban development.

PubMed

Zhou, Min; Tan, Shukui; Zhang, Lu

2015-01-01

Land use planning is always officially implemented as an effective tool to control urban development and protect farmland. However, its impact on land use change remains untested in China. Using a case study of Hang-Jia-Hu region, the main objective of this paper was to investigate the influence of different land use spatial control schemes on farmland conversion and urban development. Comparisons of farmland conversion and urban development patterns between the urban planning area and the non-urban planning area were characterized by using remote sensing, geographical information systems, and landscape metrics. Results indicated that farmland conversion in the non-urban planning area was more intensive than that in the urban planning area, and that farmland patterns was more fragmented in the non-urban planning area. Built-up land patterns in the non-urban planning area showed a trend of aggregation, while those in the urban planning area had a dual trend of fragmentation and aggregation. Existing built-up areas had less influence on built-up land sprawl in the non-urban planning area than that in the urban planning area. Built-up land sprawl in the form of continuous development in the urban planning area led to farmland conversion; and in the non-urban planning area, built-up land sprawl in the form of leapfrogging development resulted in farmland areal declines and fragmentation. We argued that it is a basic requirement to integrate land use plans in urban and non-urban planning areas for land use planning and management.

Influences of Different Land Use Spatial Control Schemes on Farmland Conversion and Urban Development

PubMed Central

Zhou, Min; Tan, Shukui; Zhang, Lu

2015-01-01

Land use planning is always officially implemented as an effective tool to control urban development and protect farmland. However, its impact on land use change remains untested in China. Using a case study of Hang-Jia-Hu region, the main objective of this paper was to investigate the influence of different land use spatial control schemes on farmland conversion and urban development. Comparisons of farmland conversion and urban development patterns between the urban planning area and the non-urban planning area were characterized by using remote sensing, geographical information systems, and landscape metrics. Results indicated that farmland conversion in the non-urban planning area was more intensive than that in the urban planning area, and that farmland patterns was more fragmented in the non-urban planning area. Built-up land patterns in the non-urban planning area showed a trend of aggregation, while those in the urban planning area had a dual trend of fragmentation and aggregation. Existing built-up areas had less influence on built-up land sprawl in the non-urban planning area than that in the urban planning area. Built-up land sprawl in the form of continuous development in the urban planning area led to farmland conversion; and in the non-urban planning area, built-up land sprawl in the form of leapfrogging development resulted in farmland areal declines and fragmentation. We argued that it is a basic requirement to integrate land use plans in urban and non-urban planning areas for land use planning and management. PMID:25915897

Building foundations for the future: the NHS Scotland advanced practice succession planning development pathway.

PubMed

Currie, Kay; Grundy, Maggie

2011-10-01

To highlight implications for managers from the implementation of a national advanced practice succession planning development pathway within Scotland. Internationally, advanced practice posts have often developed in an ad-hoc manner, with little organizational attention to succession planning. Evaluation of a pilot national succession planning development pathway identified mechanisms which facilitate or hamper effective planning for advanced practice roles. A responsive evaluation design incorporating semi-structured questionnaires to pathway participants (n = 15) and semi-structured telephone interviews with case-site pathway participants (n = 7) and their line managers. Managers believed the development pathway was worthwhile; however, there was limited strategic planning to match individuals' development to service need. Practitioners generally perceived managers as interested in their development, although levels of practical support varied. There is concern from both managers and practitioners regarding ongoing funding for advanced practice development. The present evaluation study reiterates the need for organizational commitment to succession planning including robust service needs analysis mechanisms and adequate funding for development processes. Nurse managers are viewed as the 'gatekeepers' to opportunities for developing advanced nurse practitioners; scare resources must be targeted effectively to support succession planning through the development of selected individuals for future advanced practice posts, justified by service need. © 2011 Blackwell Publishing Ltd.

Management Development: The State of the Art as Perceived by HRD Professionals.

ERIC Educational Resources Information Center

Rothwell, William J.; Kazanas, H. C.

1994-01-01

Reviews the literature on management development and summarizes results of a survey of human resources development (HRD) professionals' perceptions about management development practices. Topics discussed include identifying management development needs; strategic business plans, succession plans, and individual development plans; frequency and…

30 CFR 254.53 - Submitting a response plan developed under State requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Submitting a response plan developed under... of the Coast Line § 254.53 Submitting a response plan developed under State requirements. (a) You may submit a response plan to BSEE for approval that you developed in accordance with the laws or regulations...

30 CFR 254.53 - Submitting a response plan developed under State requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Submitting a response plan developed under... of the Coast Line § 254.53 Submitting a response plan developed under State requirements. (a) You may submit a response plan to BSEE for approval that you developed in accordance with the laws or regulations...

30 CFR 254.53 - Submitting a response plan developed under State requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Submitting a response plan developed under... Waters Seaward of the Coast Line § 254.53 Submitting a response plan developed under State requirements. (a) You may submit a response plan to MMS for approval that you developed in accordance with the laws...

30 CFR 254.53 - Submitting a response plan developed under State requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Submitting a response plan developed under... of the Coast Line § 254.53 Submitting a response plan developed under State requirements. (a) You may submit a response plan to BSEE for approval that you developed in accordance with the laws or regulations...

24 CFR 598.605 - Implementation plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Implementation plan. 598.605 Section 598.605 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.605 Implementation plan. (a) Implementation plan content. An EZ must submit an...

43 CFR 10005.17 - Plan development process.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Plan development process. 10005.17 Section 10005.17 Public Lands: Interior Regulations Relating to Public Lands (Continued) UTAH RECLAMATION...'S MITIGATION AND CONSERVATION PLAN § 10005.17 Plan development process. Following adoption of the...

14 CFR 151.5 - General policies.

Code of Federal Regulations, 2012 CFR

2012-01-01

... planning and engineering proposal or airport development project must provide for the planning or..., approval of an advance planning and engineering proposal or a project application is limited to planning or airport development necessary for civil aviation. (d) Stage development. In any case in which airport...

14 CFR 151.5 - General policies.

Code of Federal Regulations, 2013 CFR

2013-01-01

... planning and engineering proposal or airport development project must provide for the planning or..., approval of an advance planning and engineering proposal or a project application is limited to planning or airport development necessary for civil aviation. (d) Stage development. In any case in which airport...

14 CFR 151.5 - General policies.

Code of Federal Regulations, 2014 CFR

2014-01-01

... planning and engineering proposal or airport development project must provide for the planning or..., approval of an advance planning and engineering proposal or a project application is limited to planning or airport development necessary for civil aviation. (d) Stage development. In any case in which airport...

14 CFR 151.5 - General policies.

Code of Federal Regulations, 2011 CFR

2011-01-01

... planning and engineering proposal or airport development project must provide for the planning or..., approval of an advance planning and engineering proposal or a project application is limited to planning or airport development necessary for civil aviation. (d) Stage development. In any case in which airport...

14 CFR 151.5 - General policies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... planning and engineering proposal or airport development project must provide for the planning or..., approval of an advance planning and engineering proposal or a project application is limited to planning or airport development necessary for civil aviation. (d) Stage development. In any case in which airport...

36 CFR 910.10 - General.

Code of Federal Regulations, 2011 CFR

2011-07-01

... AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.10 General. To facilitate review of each development proposal in light of the identified urban planning and design goals of the Plan, the following urban...

36 CFR 910.10 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.10 General. To facilitate review of each development proposal in light of the identified urban planning and design goals of the Plan, the following urban...

A model of succession planning for mental health nurse practitioners.

PubMed

Hampel, Sally; Procter, Nicholas; Deuter, Kate

2010-08-01

This paper reviews current literature on succession planning for mental health nurse practitioners (NPs) and discusses a model of succession planning that is underpinned by principals of leadership development, workforce participation and client engagement. The paper identifies succession planning as a means of managing a present and future workforce, while simultaneously addressing individual and organizational learning and practice development needs. A discussion of the processes attendant upon sustainable succession planning - collegial support, career planning and development, information exchange, capacity building, and mentoring is framed within the potential interrelationships between existing NP, developing NP and service directors and/or team managers. Done effectively and in partnership with wider clinical services, succession planning has the potential to build NP leadership development and leadership transition more broadly within mental health services.

NASCOM system development plan: System description, capabilities, and plans, FY 94-2

NASA Technical Reports Server (NTRS)

1994-01-01

The Nascom System Development Plan (NSDP) for FY 94-2 contains 17 sections. It is a management document containing the approved plan for maintaining the Nascom Network System. Topics covered include an overview of Nascom systems and services, major ground communication support systems, low-speed data system, voice system, high-speed data system, Nascom support for NASA networks, Nascom planning for NASA missions, and network upgrade and advanced systems developments and plans.

24 CFR 598.400 - HUD grants for planning activities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... process describes the procedures for award of these planning grants, post-award reporting requirements... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false HUD grants for planning activities... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF...

24 CFR 598.605 - Implementation plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Implementation plan. 598.605 Section 598.605 Housing and Urban Development Regulations Relating to Housing and Urban Development... Empowerment Zone Grants § 598.605 Implementation plan. (a) Implementation plan content. An EZ must submit an...

24 CFR 598.605 - Implementation plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Implementation plan. 598.605 Section 598.605 Housing and Urban Development Regulations Relating to Housing and Urban Development... Empowerment Zone Grants § 598.605 Implementation plan. (a) Implementation plan content. An EZ must submit an...

44 CFR 78.5 - Flood Mitigation Plan development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Flood Mitigation Plan development. 78.5 Section 78.5 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... MITIGATION ASSISTANCE § 78.5 Flood Mitigation Plan development. A Flood Mitigation Plan will articulate a...

44 CFR 78.5 - Flood Mitigation Plan development.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Flood Mitigation Plan development. 78.5 Section 78.5 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... MITIGATION ASSISTANCE § 78.5 Flood Mitigation Plan development. A Flood Mitigation Plan will articulate a...

36 CFR 910.58 - Development.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE..., planned unit development, or project resulting from the process of planning, land acquisition, demolition...

36 CFR 910.58 - Development.

Code of Federal Regulations, 2011 CFR

2011-07-01

... GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE..., planned unit development, or project resulting from the process of planning, land acquisition, demolition...

Climate Action Planning Process | Climate Neutral Research Campuses | NREL

Science.gov Websites

Action Planning Process Climate Action Planning Process For research campuses, NREL has developed a five-step process to develop and implement climate action plans: Determine baseline energy consumption Analyze technology options Prepare a plan and set priorities Implement the climate action plan Measure and

Planning and Second Language Development in Task-Based Synchronous Computer-Mediated Communication

ERIC Educational Resources Information Center

Hsu, Hsiu-Chen

2012-01-01

This dissertation explored the effect of two planning conditions (the multiple planning condition with rehearsal and online planning time, and the single planning condition with online planning time only) on L2 production complexity and accuracy and the subsequent development of these two linguistic areas in the context of written synchronous…

44 CFR 350.6 - Assistance in development of State and local plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

... State and local plans. 350.6 Section 350.6 Emergency Management and Assistance FEDERAL EMERGENCY... radiological emergency response plans, and will review plans and observe exercises to evaluate the adequacy of... RADIOLOGICAL EMERGENCY PLANS AND PREPAREDNESS § 350.6 Assistance in development of State and local plans. (a...

36 CFR 910.15 - New development design.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.15 New development design. (a) All new development shall represent the best contemporary architectural and urban planning concepts...

36 CFR 910.15 - New development design.

Code of Federal Regulations, 2011 CFR

2011-07-01

... GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.15 New development design. (a) All new development shall represent the best contemporary architectural and urban planning concepts...

Developing Service Plans: A Resource Manual for American Indian/Alaska Native Head Start/Early Head Start Grantees

ERIC Educational Resources Information Center

Academy for Educational Development, 2006

2006-01-01

This "Developing Service Plans" guide is a tool to assist grantees in the development of written service plans. It provides a structure that can be tailored to meet the needs of individual grantees. Services Plans are a management tool for planning, organizing and implementing Head Start program services to children and families. As stated in the…

23 CFR 710.303 - Planning.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Planning. 710.303 Section 710.303 Highways FEDERAL... ESTATE Project Development § 710.303 Planning. State and local governments conduct metropolitan and statewide planning to develop coordinated, financially constrained system plans to meet transportation needs...

Information Communication Technology Planning in Developing Countries

ERIC Educational Resources Information Center

Malapile, Sandy; Keengwe, Jared

2014-01-01

This article explores major issues related to Information Communication Technology (ICT) in education and technology planning. Using the diffusion of innovation theory, the authors examine technology planning opportunities and challenges in Developing countries (DCs), technology planning trends in schools, and existing technology planning models…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaks, D; Fletcher, R; Salamon, S

Purpose: To develop an online framework that tracks a patient’s plan from initial simulation to treatment and that helps automate elements of the physics plan checks usually performed in the record and verify (RV) system and treatment planning system. Methods: We have developed PlanTracker, an online plan tracking system that automatically imports new patients tasks and follows it through treatment planning, physics checks, therapy check, and chart rounds. A survey was designed to collect information about the amount of time spent by medical physicists in non-physics related tasks. We then assessed these non-physics tasks for automation. Using these surveys, wemore » directed our PlanTracker software development towards the automation of intra-plan physics review. We then conducted a systematic evaluation of PlanTracker’s accuracy by generating test plans in the RV system software designed to mimic real plans, in order to test its efficacy in catching errors both real and theoretical. Results: PlanTracker has proven to be an effective improvement to the clinical workflow in a radiotherapy clinic. We present data indicating that roughly 1/3 of the physics plan check can be automated, and the workflow optimized, and show the functionality of PlanTracker. When the full system is in clinical use we will present data on improvement of time use in comparison to survey data prior to PlanTracker implementation. Conclusion: We have developed a framework for plan tracking and automatic checks in radiation therapy. We anticipate using PlanTracker as a basis for further development in clinical/research software. We hope that by eliminating the most simple and time consuming checks, medical physicists may be able to spend their time on plan quality and other physics tasks rather than in arithmetic and logic checks. We see this development as part of a broader initiative to advance the clinical/research informatics infrastructure surrounding the radiotherapy clinic. This research project has been financially supported by Varian Medical Systems, Palo Alto, CA, through a Varian MRA.« less

Planning for Interagency Cooperation in Rural Development. CARD Report 45.

ERIC Educational Resources Information Center

Rogers, David L.; Glick, Edward L.

With a major emphasis on cooperative planning in rural development, three elements of development process were identified: (1) integration of units involved, occurring when several organizations contribute to a larger collective effort; (2) decentralized planning and local initiative, occurring when planning initiative is at the local level; (3)…

15 CFR 921.13 - Management plan and environmental impact statement development.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Management plan and environmental... Selection, Post Site Selection and Management Plan Development § 921.13 Management plan and environmental... of acquisition and development. A categorical exclusion, environmental assessment, or EIS may be...

15 CFR 921.13 - Management plan and environmental impact statement development.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Management plan and environmental... Selection, Post Site Selection and Management Plan Development § 921.13 Management plan and environmental... of acquisition and development. A categorical exclusion, environmental assessment, or EIS may be...

15 CFR 921.13 - Management plan and environmental impact statement development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Management plan and environmental... Selection, Post Site Selection and Management Plan Development § 921.13 Management plan and environmental... of acquisition and development. A categorical exclusion, environmental assessment, or EIS may be...

34 CFR 200.27 - Development of a schoolwide program plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... school year. (2) The school must develop the comprehensive plan with the involvement of parents... comprehensive plan to improve teaching and learning throughout the school. (2) The school must develop the..., parents, and the public. (2) Information in the plan must be— (i) In an understandable and uniform format...

77 FR 4824 - Notice of Revised Information Collection for Public Comment; Consolidated Plan & Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

... Secretary for Community Planning and Development, HUD. ACTION: Notice of revised information collection for... Community Planning and Development (CPD) programs described below will be submitted to the Office of... Community Planning and Development, telephone (202) 402-3669 (this is not a toll- free number...

23 CFR 450.318 - Transportation planning studies and project development.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Transportation planning studies and project development... § 450.318 Transportation planning studies and project development. (a) Pursuant to section 1308 of the... transportation operator(s) may undertake a multimodal, systems-level corridor or subarea planning study as part...

7 CFR 761.10 - Planning and performing construction and other development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 7 2011-01-01 2011-01-01 false Planning and performing construction and other... Provisions § 761.10 Planning and performing construction and other development. (a) Purpose. This section describes Agency policies regarding the planning and performing of construction and other development work...

Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan. [Contains glossary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This plan covers robotics Research, Development, Demonstration, Testing, activities in the Program for the next five years. These activities range from bench-scale R D to fullscale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and an initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management operations at DOE sites to be safer, faster and cheaper. Fivemore » priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. This 5-Year Program Plan discusses the overall approach to be adopted by the RTDP to aggressively develop robotics technology and contains discussions of the Program Management Plan, Site Visit and Needs Summary, Approach to Needs-Directed Technical Development, Application-Specific Technical Development, and Cross-Cutting and Advanced Technology. Integrating application-specific ER WM needs, the current state of robotics technology, and the potential benefits (in terms of faster, safer, and cheaper) of new technology, the Plan develops application-specific road maps for robotics RDDT E for the period FY 1991 through FY 1995. In addition, the Plan identifies areas where longer-term research in robotics will have a high payoff in the 5- to 20-year time frame. 12 figs.« less

CRI planning and scheduling for space

NASA Technical Reports Server (NTRS)

Aarup, Mads

1994-01-01

Computer Resources International (CRI) has many years of experience in developing space planning and scheduling systems for the European Space Agency. Activities range from AIT/AIV planning over mission planning to research in on-board autonomy using advanced planning and scheduling technologies in conjunction with model based diagnostics. This article presents four projects carried out for ESA by CRI with various subcontractors: (1) DI, Distributed Intelligence for Ground/Space Systems is an on-going research project; (2) GMPT, Generic Mission Planning Toolset, a feasibility study concluded in 1993; (3) OPTIMUM-AIV, Open Planning Tool for AIV, development of a knowledge based AIV planning and scheduling tool ended in 1992; and (4) PlanERS-1, development of an AI and knowledge-based mission planning prototype for the ERS-1 earth observation spacecraft ended in 1991.

36 CFR 219.5 - Planning framework.

Code of Federal Regulations, 2014 CFR

2014-07-01

... and allows the Forest Service to adapt to changing conditions, including climate change, and improve... need to change the plan based on the assessment, development of a proposed plan, consideration of the... for amending a plan includes: Preliminary identification of the need to change the plan, development...

36 CFR 219.5 - Planning framework.

Code of Federal Regulations, 2012 CFR

2012-07-01

... and allows the Forest Service to adapt to changing conditions, including climate change, and improve... need to change the plan based on the assessment, development of a proposed plan, consideration of the... for amending a plan includes: Preliminary identification of the need to change the plan, development...

36 CFR 219.5 - Planning framework.

Code of Federal Regulations, 2013 CFR

2013-07-01

... and allows the Forest Service to adapt to changing conditions, including climate change, and improve... need to change the plan based on the assessment, development of a proposed plan, consideration of the... for amending a plan includes: Preliminary identification of the need to change the plan, development...

23 CFR 450.212 - Transportation planning studies and project development.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Transportation planning studies and project development. 450.212 Section 450.212 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450...

Science-based strategic planning for hazardous fuel treatment.

Treesearch

D.L. Peterson; M.C. Johnson

2007-01-01

A scientific foundation coupled with technical support is needed to develop long-term strategic plans for fuel and vegetation treatments on public lands. These plans are developed at several spatial scales and are typically a component of fire management plans and other types of resource management plans. Such plans need to be compatible with national, regional, and...

Busting myths and building resilience: Practices and approaches that go beyond mere plan development.

PubMed

Armour, Mark

Dwight D. Eisenhower is often quoted as saying: 'In battle, plans are useless but planning is indispensable'. How many in the business continuity profession actually think about that statement and what it really means? Audit, compliance and regulatory requirements as well as the expectations of executives and business leaders result in an inordinate amount of time and effort devoted to plan development with scant attention paid to actual planning. Practitioners need to realise that the value of the plans they develop is not derived from the finished documents but from the work devoted to completing them. Experience and practice win out above detailed plans. One need look no further than Eisenhower's D-Day invasion of Normandy as evidence. Practitioners need to learn how to be better at instituting preparedness and not simply developing better plans.

24 CFR 91.315 - Strategic plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Strategic plan. 91.315 Section 91... CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS State Governments; Contents of Consolidated Plan § 91.315 Strategic plan. (a) General. For the categories described in paragraphs (b), (c), (d...

24 CFR 570.415 - Community Development Work Study Program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and economic development, community planning, and community management. The primary objectives of the... economic development, community planning, and community management, and to provide a cadre of well... economic development, community planning, community management, land use and housing activities. Community...

Creating Partnerships for a Better Tennessee. Master Plan, 2005-2010

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2010

2010-01-01

The Tennessee Higher Education Commission is statutorily charged to develop a statewide master plan for the future development of public higher education. In response to this, the Master Plan, "Creating Partnerships for a Better Tennessee," was developed for 2005-2010. The Master Plan is a collaborative effort with the Tennessee Board of…

Development of an Updated Strategic Marketing Plan for Fox Valley Technical College.

ERIC Educational Resources Information Center

May, Susan A.

This project was conducted to develop a comprehensive strategic marketing plan for Fox Valley Technical College (FVTC). Components included a review of the literature, establishing criteria for the plan, validation of the criteria, the actual development of the plan involving a formative committee, and the review of institutional marketing plans…

30 CFR 254.53 - Submitting a response plan developed under State requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Submitting a response plan developed under....53 Submitting a response plan developed under State requirements. (a) You may submit a response plan... Federal officials and response personnel if there is a spill. (3) Identify any private personnel and...

Developing the plan

NASA Technical Reports Server (NTRS)

1975-01-01

The basic sequence in the planning development process is discussed. Alternative ways of satisfying estimated needs, and the selection of an alternative are described along with the development of a plan to implement the selected alternative.

Planning guidance for the Chemical Stockpile Emergency Preparedness Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shumpert, B.L.; Watson, A.P.; Sorensen, J.H.

1995-02-01

This planning guide was developed under the direction of the U.S. Army and the Federal Emergency Management Agency (FEMA) which jointly coordinate and direct the development of the Chemical Stockpile Emergency Preparedness Program (CSEPP). It was produced to assist state, local, and Army installation planners in formulating and coordinating plans for chemical events that may occur at the chemical agent stockpile storage locations in the continental United States. This document provides broad planning guidance for use by both on-post and off-post agencies and organizations in the development of a coordinated plan for responding to chemical events. It contains checklists tomore » assist in assuring that all important aspects are included in the plans and procedures developed at each Chemical Stockpile Disposal Program (CSDP) location. The checklists are supplemented by planning guidelines in the appendices which provide more detailed guidance regarding some issues. The planning guidance contained in this document will help ensure that adequate coordination between on-post and off-post planners occurs during the planning process. This planning guide broadly describes an adequate emergency planning base that assures that critical planning decisions will be made consistently at every chemical agent stockpile location. This planning guide includes material drawn from other documents developed by the FEMA, the Army, and other federal agencies with emergency preparedness program responsibilities. Some of this material has been developed specifically to meet the unique requirements of the CSEPP. In addition to this guidance, other location-specific documents, technical studies, and support studies should be used as needed to assist in the planning at each of the chemical agent stockpile locations to address the specific hazards and conditions at each location.« less

Airport Capital Improvement Planning: Stewardship for Airport Development

DOT National Transportation Integrated Search

1997-09-01

"Airport Capital Improvement Planning: Stewardship for Airport Development", was : originally written in October, 1995. It documented an effort to implement the : concept of capital improvement planning with the airport development industry. : Airpor...

75 FR 80850 - Development of Strategic Plan 2011-2015

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... intended for use as LSC embarks on its planning process. LSC anticipates publishing a draft Strategic Plan... process to develop a Strategic Plan for the years 2011-2015. Toward that end, LSC is soliciting... strategic planning efforts. In addition, Among other sources, LSC is considering the guidance provided by...

30 CFR 250.286 - What is a DWOP?

Code of Federal Regulations, 2010 CFR

2010-07-01

... OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Deepwater Operations Plans (dwop) § 250.286 What is a DWOP? (a) A DWOP is a plan that provides sufficient information for MMS to review a deepwater... the regulations such as Exploration Plans, Development and Production Plans, and Development...

36 CFR 910.11 - Comprehensive urban planning and design.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Comprehensive urban planning... CORPORATION GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.11 Comprehensive urban planning...

46 CFR 126.330 - Plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Plans. 126.330 Section 126.330 Shipping COAST GUARD... Inspection § 126.330 Plans. Before construction starts, the owner, operator, or builder shall develop plans indicating the proposed arrangement and construction of the vessel. (The list of plans to be developed and...

24 CFR 572.200 - Planning grants.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Planning grants. 572.200 Section...) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN....200 Planning grants. Any planning grants made by HUD under the HOPE 3 program will continue to be...

23 CFR 420.107 - What is the minimum required expenditure of State planning and research funds for research...

Code of Federal Regulations, 2010 CFR

2010-04-01

... planning and research funds for research development and technology transfer? 420.107 Section 420.107 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING AND... minimum required expenditure of State planning and research funds for research development and technology...

Space Station Mission Planning Study (MPS) development study. Volume 3: Software development plan

NASA Technical Reports Server (NTRS)

Klus, W. L.

1987-01-01

A software development plan is presented for the definition, design, and implementation of the Space Station (SS) Payload Mission Planning System (MPS). This plan is an evolving document and must be updated periodically as the SS design and operations concepts as well as the SS MPS concept evolve. The major segments of this plan are as follows: an overview of the SS MPS and a description of its required capabilities including the computer programs identified as configurable items with an explanation of the place and function of each within the system; an overview of the project plan and a detailed description of each development project activity breaking each into lower level tasks where applicable; identification of the resources required and recommendations for the manner in which they should be utilized including recommended schedules and estimated manpower requirements; and a description of the practices, standards, and techniques recommended for the SS MPS Software (SW) development.

Health workforce development planning in the Sultanate of Oman: a case study.

PubMed

Ghosh, Basu

2009-06-11

Oman's recent experience in health workforce development may be viewed against the backdrop of the situation just three or four decades ago, when it had just a few physicians and nurses (mostly expatriate). All workforce categories in Oman have grown substantially over the last two decades. Increased self-reliance was achieved despite substantial growth in workforce stocks. Stocks of physicians and nurses grew significantly during 1985-2007. This development was the outcome of well-considered national policies and plans. This case outlines how Oman is continuing to turn around its excessive dependence on expatriate workforce through strategic workforce development planning. The Sultanate's early development initiatives focused on building a strong health care infrastructure by importing workforce. However, the policy-makers stressed national workforce development for a sustainable future. Beginning with the formulation of a strategic health workforce development plan in 1991, the stage was set for adopting workforce planning as an essential strategy for sustainable health development and workforce self-reliance. Oman continued to develop its educational infrastructure, and began to produce as much workforce as possible, in order to meet health care demands and achieve workforce self-reliance. Other policy initiatives with a beneficial impact on Oman's workforce development scenario were: regionalization of nursing institutes, active collaboration with universities and overseas specialty boards, qualitative improvement of the education system, development of a strong continuing professional development system, efforts to improve workforce management, planned change management and needs-based micro/macro-level studies. Strong political will and bold policy initiatives, dedicated workforce planning and educational endeavours have all contributed to help Oman to develop its health workforce stocks and gain self-reliance. Oman has successfully innovated workforce planning within a favorable policy environment. Its intensive and extensive workforce planning efforts, with the close involvement of policy-makers, educators and workforce managers, have ensured adequacy of suitable workforce in health institutions and its increased self-reliance in the health workforce. Oman's experience in workforce planning and development presents an illustration of a country benefiting from successful application of workforce planning concepts and tools. Instead of being complacent about its achievements so far, every country needs to improve or sustain its planning efforts in this way, in order to circumvent the current workforce deficiencies and to further increase self-reliance and improve workforce efficiency and effectiveness.

Health workforce development planning in the Sultanate of Oman: a case study

PubMed Central

Ghosh, Basu

2009-01-01

Introduction Oman's recent experience in health workforce development may be viewed against the backdrop of the situation just three or four decades ago, when it had just a few physicians and nurses (mostly expatriate). All workforce categories in Oman have grown substantially over the last two decades. Increased self-reliance was achieved despite substantial growth in workforce stocks. Stocks of physicians and nurses grew significantly during 1985–2007. This development was the outcome of well-considered national policies and plans. This case outlines how Oman is continuing to turn around its excessive dependence on expatriate workforce through strategic workforce development planning. Case description The Sultanate's early development initiatives focused on building a strong health care infrastructure by importing workforce. However, the policy-makers stressed national workforce development for a sustainable future. Beginning with the formulation of a strategic health workforce development plan in 1991, the stage was set for adopting workforce planning as an essential strategy for sustainable health development and workforce self-reliance. Oman continued to develop its educational infrastructure, and began to produce as much workforce as possible, in order to meet health care demands and achieve workforce self-reliance. Other policy initiatives with a beneficial impact on Oman's workforce development scenario were: regionalization of nursing institutes, active collaboration with universities and overseas specialty boards, qualitative improvement of the education system, development of a strong continuing professional development system, efforts to improve workforce management, planned change management and needs-based micro/macro-level studies. Strong political will and bold policy initiatives, dedicated workforce planning and educational endeavours have all contributed to help Oman to develop its health workforce stocks and gain self-reliance. Discussion and evaluation Oman has successfully innovated workforce planning within a favorable policy environment. Its intensive and extensive workforce planning efforts, with the close involvement of policy-makers, educators and workforce managers, have ensured adequacy of suitable workforce in health institutions and its increased self-reliance in the health workforce. Conclusion Oman's experience in workforce planning and development presents an illustration of a country benefiting from successful application of workforce planning concepts and tools. Instead of being complacent about its achievements so far, every country needs to improve or sustain its planning efforts in this way, in order to circumvent the current workforce deficiencies and to further increase self-reliance and improve workforce efficiency and effectiveness. PMID:19519912

BOOK REVIEW : Future Professional Communication in Astronomy. Proceedings of the Colloquium held at the Palace of the Academies, Brussels, 10-13 June 2007

NASA Astrophysics Data System (ADS)

Duerbeck, H. W.; Heck, A.; Houziaux, L.

These are the timely and well-edited proceedings of a colloquium dealing with the present state and the future of "communication'' in astronomy. While communication in the past was mainly restricted to printed journals, conferences and colloquia, things have changed dramatically in the last decades. Journals have gone online, and runs of paper copies are slowly declining. 25 astronomers and representatives of various publishing institutions met in Brussels in June 2007 to discuss the future and the different options of information communication and -exchange. 16 contributions are supplemented by summaries of discussions held at the meeting. After a general overview of one of the organizers, who has played a key role in various aspects of information exchange, several representatives discuss future plans of their publications: K.B. Marvel presents the AAS journals (ApJ parts I and II, ApJS, AJ, which are just being transferred from the University of Chicago Press to Institute of Physics Publishing). P. Murdin represents the RAS and its main journal, the MNRAS. "Open Access'' is of course one of the key words of this conference. Producing a journal (either on paper or electronically) is expensive. For the AAS journals, these costs are shared between authors andsubscribers. Future plans are to abandon "paper copies'' at all, although "printable pages'' will continue to be provided. For MNRAS, it is the subscribers who pay. And if it would have "open access'', authors would have to be charged for publication.Some research funding agencies demand that scientific results that they have sponsored should appear online, and freely available (at least after a certaintime). Various approaches were outlined by representatives of publishers (Wiley-Blackwell, Springer, Elsevier, EDP Sciences). S. Plaszczynski introduced a project for "open access'' in the field of high energy physics. To replace "repositories'' and collections of "preprints'' that may have never made it to the pages of journals for various reasons, a SCOAP model was initiated. This "Sponsoring Consortium for Open Access Publishing in Particle Physics'' will be a global network of funding agencies, laboratories and libraries that will provide the necessary funding for publishing material in the main journals for high energy physics (involving four publishers). M. Kurtz outlined the "Open access policy'' of Smithsonian/NASA Astrophysics Data System (ADS), while T. Mahoney voiced some caution, since open access may lead to a deterioration or even collapse of the publication process. W. B. Burton and H. A. Abt discussed long-term trends in research literature, while C. Madsen and L. L. Christensen discussed aspects of communication of specialists with politicians and the public. We could only give a brief summary of this book. Many thought-provoking ideas simply defied being abstracted. Anyone who is interested in the publication process in astronomy and its aspects in the future will find a lot of interesting reading in these proceedings.

33 CFR 154.1045 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Response plan development and... (CONTINUED) POLLUTION FACILITIES TRANSFERRING OIL OR HAZARDOUS MATERIAL IN BULK Response Plans for Oil Facilities § 154.1045 Response plan development and evaluation criteria for facilities that handle, store, or...

33 CFR 154.1045 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Response plan development and... (CONTINUED) POLLUTION FACILITIES TRANSFERRING OIL OR HAZARDOUS MATERIAL IN BULK Response Plans for Oil Facilities § 154.1045 Response plan development and evaluation criteria for facilities that handle, store, or...

33 CFR 154.1045 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Response plan development and... (CONTINUED) POLLUTION FACILITIES TRANSFERRING OIL OR HAZARDOUS MATERIAL IN BULK Response Plans for Oil Facilities § 154.1045 Response plan development and evaluation criteria for facilities that handle, store, or...

33 CFR 154.1045 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Response plan development and... (CONTINUED) POLLUTION FACILITIES TRANSFERRING OIL OR HAZARDOUS MATERIAL IN BULK Response Plans for Oil Facilities § 154.1045 Response plan development and evaluation criteria for facilities that handle, store, or...

7 CFR 22.306 - Financing rural development planning.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Financing rural development planning. 22.306 Section 22.306 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION Roles and... Department of Housing and Urban Development planning and management assistance program or other available...

24 CFR 91.215 - Strategic plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Strategic plan. 91.215 Section 91.215 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS Local Governments; Contents of...

24 CFR 91.215 - Strategic plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Strategic plan. 91.215 Section 91.215 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS Local Governments; Contents of...

24 CFR 91.215 - Strategic plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Strategic plan. 91.215 Section 91.215 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS Local Governments; Contents of...

Enroute flight planning: Evaluating design concepts for the development of cooperative problem-solving concepts

NASA Technical Reports Server (NTRS)

Smith, Philip J.; Mccoy, C. Elaine

1991-01-01

The goals of this research were to develop design concepts to support the task of enroute flight planning. And within this context, to explore and evaluate general design concepts and principles to guide the development of cooperative problem solving systems. A detailed model is to be developed of the cognitive processes involved in flight planning. Included in this model will be the identification of individual differences of subjects. Of particular interest will be differences between pilots and dispatchers. The effect will be studied of the effect on performance of tools that support planning at different levels of abstraction. In order to conduct this research, the Flight Planning Testbed (FPT) was developed, a fully functional testbed environment for studying advanced design concepts for tools to aid in flight planning.

Streamlining Collaborative Planning in Spacecraft Mission Architectures

NASA Technical Reports Server (NTRS)

Misra, Dhariti; Bopf, Michel; Fishman, Mark; Jones, Jeremy; Kerbel, Uri; Pell, Vince

2000-01-01

During the past two decades, the planning and scheduling community has substantially increased the capability and efficiency of individual planning and scheduling systems. Relatively recently, research work to streamline collaboration between planning systems is gaining attention. Spacecraft missions stand to benefit substantially from this work as they require the coordination of multiple planning organizations and planning systems. Up to the present time this coordination has demanded a great deal of human intervention and/or extensive custom software development efforts. This problem will become acute with increased requirements for cross-mission plan coordination and multi -spacecraft mission planning. The Advanced Architectures and Automation Branch of NASA's Goddard Space Flight Center is taking innovative steps to define collaborative planning architectures, and to identify coordinated planning tools for Cross-Mission Campaigns. Prototypes are being developed to validate these architectures and assess the usefulness of the coordination tools by the planning community. This presentation will focus on one such planning coordination too], named Visual Observation Layout Tool (VOLT), which is currently being developed to streamline the coordination between astronomical missions

24 CFR 972.133 - Public and resident consultation process for developing a conversion plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Public and resident consultation process for developing a conversion plan. 972.133 Section 972.133 Housing and Urban Development... ASSISTANCE Required Conversion of Public Housing Developments Conversion Plans § 972.133 Public and resident...

24 CFR 903.12 - What are the streamlined Annual Plan requirements for small PHAs?

Code of Federal Regulations, 2010 CFR

2010-04-01

... Plan requirements for small PHAs? 903.12 Section 903.12 Housing and Urban Development Regulations... HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT PUBLIC HOUSING AGENCY PLANS PHA Plans § 903.12 What are the streamlined Annual Plan requirements for small PHAs? (a) General. PHAs with less than 250...

Statewide ITS development and deployment plan

DOT National Transportation Integrated Search

2002-10-01

This plan was developed to create a means to implement the ongoing, short-term and long-term activities identified in the Statewide ITS Action Plan. As part of the process for organizing the approximately seventy-five Action Plan activities, these we...

Strategic planning: getting from here to there.

PubMed

Kaleba, Richard

2006-11-01

Hospitals should develop a strategic plan that defines specific actions in a realistic time frame. Hospitals can follow a five-phase process to develop a strategic plan. The strategic planning process requires a project leader and medical staff buy-in.

Momentum: "Developing Masterful Marketing Plans."

ERIC Educational Resources Information Center

Meservey, Lynne D.

1988-01-01

Describes how directors can plan and develop a written marketing plan which can increase enrollment at child care centers. Components of successful marketing plans include parent retention; program merchandising; staff and director training; sales promotions; networking; and enrichment programs/fundraising. (NH)

7 CFR 22.306 - Financing rural development planning.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Financing rural development planning. 22.306 Section 22.306 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION Roles and Responsibilities of State Governments § 22.306 Financing rural development planning. States will be required to...

24 CFR 91.235 - Special case; abbreviated consolidated plan.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Special case; abbreviated consolidated plan. 91.235 Section 91.235 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS...

24 CFR 91.235 - Special case; abbreviated consolidated plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Special case; abbreviated consolidated plan. 91.235 Section 91.235 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS...

24 CFR 91.235 - Special case; abbreviated consolidated plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Special case; abbreviated consolidated plan. 91.235 Section 91.235 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS...

24 CFR 91.235 - Special case; abbreviated consolidated plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Special case; abbreviated consolidated plan. 91.235 Section 91.235 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS...

24 CFR 91.235 - Special case; abbreviated consolidated plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Special case; abbreviated consolidated plan. 91.235 Section 91.235 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS...

An Analysis of Current Operational Contract Support Planning Doctrine

DTIC Science & Technology

2015-09-01

P). This project argues for the balanced development of OCS planning acquisition and non-acquisition focused resources to effectively integrate this...planning guidance developed is appropriate for initial entry operations applicable to various levels of theater maturity. 14. SUBJECT TERMS...balanced development of OCS planning acquisition and non- acquisition focused resources to effectively integrate this function across disciplines. The

43 CFR 3931.10 - Exploration plans and plans of development for mining and in situ operations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... for mining and in situ operations. 3931.10 Section 3931.10 Public Lands: Interior Regulations Relating....10 Exploration plans and plans of development for mining and in situ operations. (a) The POD must... development of the oil shale resources in the lease. (b) The operator must submit to the proper BLM office an...

43 CFR 3931.10 - Exploration plans and plans of development for mining and in situ operations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... for mining and in situ operations. 3931.10 Section 3931.10 Public Lands: Interior Regulations Relating....10 Exploration plans and plans of development for mining and in situ operations. (a) The POD must... development of the oil shale resources in the lease. (b) The operator must submit to the proper BLM office an...

43 CFR 3931.10 - Exploration plans and plans of development for mining and in situ operations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for mining and in situ operations. 3931.10 Section 3931.10 Public Lands: Interior Regulations Relating....10 Exploration plans and plans of development for mining and in situ operations. (a) The POD must... development of the oil shale resources in the lease. (b) The operator must submit to the proper BLM office an...

43 CFR 3931.10 - Exploration plans and plans of development for mining and in situ operations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... for mining and in situ operations. 3931.10 Section 3931.10 Public Lands: Interior Regulations Relating....10 Exploration plans and plans of development for mining and in situ operations. (a) The POD must... development of the oil shale resources in the lease. (b) The operator must submit to the proper BLM office an...

Typical and Atypical (Cerebral Palsy) Development of Unimanual and Bimanual Grasp Planning

ERIC Educational Resources Information Center

Janssen, Loes; Steenbergen, Bert

2011-01-01

In the present study we tested 13 children with cerebral palsy (CP) and 24 typically developing children (7-12 years old) in a unimanual and bimanual motor planning task. We focused on two research questions: (1) How does motor planning develop in children with and without CP? and (2) Is motor planning facilitated when the task is performed with…

14 CFR 152.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... use of land near a public airport, that— (1) Obstructs the airspace required for the flight of... and proposed airport facilities. Airport master planning means the development for planning purposes... specific airport. Airport system planning means the development for planning purposes of information and...

14 CFR 152.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... use of land near a public airport, that— (1) Obstructs the airspace required for the flight of... and proposed airport facilities. Airport master planning means the development for planning purposes... specific airport. Airport system planning means the development for planning purposes of information and...

14 CFR 152.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... use of land near a public airport, that— (1) Obstructs the airspace required for the flight of... and proposed airport facilities. Airport master planning means the development for planning purposes... specific airport. Airport system planning means the development for planning purposes of information and...

14 CFR 152.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... use of land near a public airport, that— (1) Obstructs the airspace required for the flight of... and proposed airport facilities. Airport master planning means the development for planning purposes... specific airport. Airport system planning means the development for planning purposes of information and...

14 CFR 152.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... use of land near a public airport, that— (1) Obstructs the airspace required for the flight of... and proposed airport facilities. Airport master planning means the development for planning purposes... specific airport. Airport system planning means the development for planning purposes of information and...

Systems design study of the Pioneer Venus spacecraft. Volume 2. Preliminary program development plan

NASA Technical Reports Server (NTRS)

1973-01-01

The preliminary development plan for the Pioneer Venus program is presented. This preliminary plan treats only developmental aspects that would have a significant effect on program cost. These significant development areas were: master program schedule planning; test planning - both unit and system testing for probes/orbiter/ probe bus; ground support equipment; performance assurance; and science integration Various test planning options and test method techniques were evaluated in terms of achieving a low-cost program without degrading mission performance or system reliability. The approaches studied and the methodology of the selected approach are defined.

Motivations and Barriers for Policymakers to Developing State Adaptation Plans

NASA Astrophysics Data System (ADS)

Miller, R.; Sylak-Glassman, E.

2016-12-01

Current approaches for developing high-quality adaptation plan require significant resources. In recent years, communities have grown to embrace adaptive plans across multiple forms, including adaptive capacity assessments, resilience strategies, and vulnerability assessments. Across the United States, as of this writing, 14 states have established adaptation plans, with another 8 states having begun the process. Given the high resources requirements and increasing interest in the development of adaptation plans, we aim to examine patterns behind the establishment of resilience plans at the state level. We examine demographic, financial, political, and physical characteristics associated with different states in an effort to explore the reasoning behind investing in the development of adaptation plans. This analysis considers quantitative and qualitative factors, including recent elections for political parties, politicians' climate-related statements and campaign promises, demographics, budgets, and regional climate threats. The analysis aims to identify motivations for state leadership taking action to develop adaptation plans. Results from the analysis seek to identify the primary drivers and barriers associated with state-wide resilience planning. These results could inform the design of scientific communication tools or approaches to aid future adaptation responses to climate change.

Development of model infectious disease protocols for fire and EMS personnel.

PubMed

Miller, Nancy L; Gudmestad, Tom; Eisenberg, Mickey S

2005-01-01

To develop model infectious disease exposure plans for emergency medical services agencies in King County, Washington. All fire departments in King County, Washington, were surveyed to determine their pathogen exposure policies. After these agencies were surveyed, model response plans were developed for both bloodborne and airborne pathogen exposure. Twenty-four of the 35 fire departments in King County submitted infectious disease exposure policies. There was diversity among the plans, and not all were deemed able to provide prophylaxis in a timely fashion. Based on this lack of uniformity among response plans, model response plans were developed for bloodborne and airborne infectious disease pathogens. Great variety was present throughout the exposure plans currently in use throughout King County, Washington. Model plans would likely universalize response to pathogen exposure and help to ensure prompt and appropriate postexposure prophylaxis.

49 CFR 37.137 - Paratransit plan development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Paratransit plan development. 37.137 Section 37... development. (a) Survey of existing services. Each submitting entity shall survey the area to be covered by... development of its paratransit plan, including at least the following: (1) Outreach. Each submitting entity...

Accomplishing and applying National Fire Plan research and development from 2001-2005

Treesearch

Baldwin V. Jr. Clark

2007-01-01

This report highlights selected accomplishments achieved by USDA Forest Service National Fire Plan Research and Development projects from 2001 through 2006. The projects highlighted here are examples of the broad range of knowledge and tools developed by the National Fire Plan Research and Development, beginning in 2001.

The Difficulties of School Development Planning

ERIC Educational Resources Information Center

Xaba, Mgadla

2006-01-01

The South African Schools Act No. 84 of 1996 requires that school governing bodies develop school mission statements and, by implication, school development plans. The Gauteng Regulations and Rules for Public School Governing Bodies specifically direct school governing bodies to draw up and amend school development plans. Whilst training in…

76 FR 20364 - Notice of Proposed Information Collection: Comment Request; Technical Assistance for Community...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... Information Collection: Comment Request; Technical Assistance for Community Planning and Development Programs AGENCY: Office of the Assistant Secretary for Community Planning And Development, HUD. ACTION: Notice... Community Planning and Development, Department of Housing Urban and Development, 451 7th Street, SW., Room...

Alaska Department of Labor and Workforce Development

Science.gov Websites

; Workforce Development > Alaska Maritime Workforce Development Plan FIND A MARITIME JOB SIGN UP TO RECEIVE MARITIME JOB UPDATES REQUEST A PRESENTATION OF THE PLAN TO YOUR ORGANIZATION CONTACT US Homer Marine Trades Association Resolution in Support of the Alaska Maritime Workforce Development Plan Kenai Peninsula Borough

7 CFR 4284.621 - Eligible grant purposes.

Code of Federal Regulations, 2011 CFR

2011-01-01

... by providing technical assistance for business development and economic development planning. Grant...-county economic development planning; (5) Establish centers for training, technology, and trade that will... professional services necessary to conduct the technical assistance, training, or planning functions. (b...

Maintaining technical excellence requires a national plan

NASA Technical Reports Server (NTRS)

Davidson, T. F.

1991-01-01

To meet the challenge of technical excellence, AIA established a rocket propulsion committee to develop the National Rocket Propulsion Strategic Plan. Developing such a plan required a broad spectrum of experience and disciplines. The Strategic Plan team needed the participation of industry, government, and academia. The plan provides, if followed, a means for the U.S. to maintain technical excellence and world leadership in rocket propulsion. To implement the National Rocket Propulsion Strategic Plan is to invest in the social, economic, and technological futures of America. The plan lays the basis for upgrading existing propulsion systems and a firm base for future full scale development, production, and operation of rocket propulsion systems for space, defense, and commercial applications.

Language Planning and Development Aid: The (In)Visibility of Language in Development Aid Discourse

ERIC Educational Resources Information Center

Taylor-Leech, Kerry; Benson, Carol

2017-01-01

Despite the essential role of local, regional, national and international languages in human development, there is little reference to language planning in development aid discourse. Beginning with definitions of development aid and language planning, the paper examines how the two were linked in pre- and post-colonial times, showing how language…

An Evaluation on Medical Education, Research and Development of AYUSH Systems of Medicine through Five Year Plans of India.

PubMed

Samal, Janmejaya; Dehury, Ranjit Kumar

2016-05-01

Indian system of medicine has its origin in India. The system is currently renamed as AYUSH, an acronym for Ayurveda, Yoga & Naturopathy, Unani, Sidha and Homeopathy. These are the six Indian systems of medicine prevalent and practiced in India and in few neighboring Asian countries. The primary objective of this review was to gain insight in to the prior and existing initiatives which would enable reflection and assist in the identification of future change. A review was carried out based on the five year plan documents, obtained from the planning commission web portal of Govt. of India, on medical education, research and development of AYUSH systems of medicine. Post independence, the process of five year planning took its birth with the initiation of long term planning in India. The planning process embraced all the social and technology sectors in it. Since the beginning of five year planning, health and family welfare planning became imperative as a social sector planning. Planning regarding Indian Systems of Medicine became a part of health and family welfare planning since then. During the entire planning process a progressive path of development could be observed as per this evaluation. A relatively sluggish process of development was observed up to seventh plan however post eighth plan the growth took its pace. Eighth plan onwards several innovative development processes could be noticed. Despite the relative developments and growth of Indian systems of medicine these systems have to face lot of criticism and appraisal owing to their various characteristic features. In the beginning the system thrived with great degree of uncertainty, as described in 1(st) five year plan, however progressed ahead with a vision to be a globally accepted system, as envisaged in 11(th) five year plan. A very strong optimistic approach in spreading India's own medical heritage is the need of the hour. The efforts are neither completely insufficient nor sufficient enough; hence a continuous endeavor for the revival and dissemination of India's own medical inheritance for the welfare of the society at large is highly desirable.

An Evaluation on Medical Education, Research and Development of AYUSH Systems of Medicine through Five Year Plans of India

PubMed Central

Dehury, Ranjit Kumar

2016-01-01

Introduction Indian system of medicine has its origin in India. The system is currently renamed as AYUSH, an acronym for Ayurveda, Yoga & Naturopathy, Unani, Sidha and Homeopathy. These are the six Indian systems of medicine prevalent and practiced in India and in few neighboring Asian countries. Objective The primary objective of this review was to gain insight in to the prior and existing initiatives which would enable reflection and assist in the identification of future change. Materials and Methods A review was carried out based on the five year plan documents, obtained from the planning commission web portal of Govt. of India, on medical education, research and development of AYUSH systems of medicine. Results Post independence, the process of five year planning took its birth with the initiation of long term planning in India. The planning process embraced all the social and technology sectors in it. Since the beginning of five year planning, health and family welfare planning became imperative as a social sector planning. Planning regarding Indian Systems of Medicine became a part of health and family welfare planning since then. During the entire planning process a progressive path of development could be observed as per this evaluation. A relatively sluggish process of development was observed up to seventh plan however post eighth plan the growth took its pace. Eighth plan onwards several innovative development processes could be noticed. Despite the relative developments and growth of Indian systems of medicine these systems have to face lot of criticism and appraisal owing to their various characteristic features. In the beginning the system thrived with great degree of uncertainty, as described in 1st five year plan, however progressed ahead with a vision to be a globally accepted system, as envisaged in 11th five year plan. Conclusion A very strong optimistic approach in spreading India’s own medical heritage is the need of the hour. The efforts are neither completely insufficient nor sufficient enough; hence a continuous endeavor for the revival and dissemination of India’s own medical inheritance for the welfare of the society at large is highly desirable. PMID:27437245

A ten-step process to develop case management plans.

PubMed

Tahan, Hussein A

2002-01-01

The use of case management plans has contained cost and improved quality of care successfully. However, the process of developing these plans remains a great challenge for healthcare executives, in this article, the author presents the answer to this challenge by discussing a 10-step formal process that administrators of patient care services and case managers can adapt to their institutions. It also can be used by interdisciplinary team members as a practical guide to develop a specific case management plan. This process is applicable to any care setting (acute, ambulatory, long term, and home care), diagnosis, or procedure. It is particularly important for those organizations that currently do not have a deliberate and systematic process to develop case management plans and are struggling with how to improve the efficiency and productivity of interdisciplinary teams charged with developing case management plans.

Planning in the Continuous Operations Environment of the International Space Station

NASA Technical Reports Server (NTRS)

Maxwell, Theresa; Hagopian, Jeff

1996-01-01

The continuous operation planning approach developed for the operations planning of the International Space Station (ISS) is reported on. The approach was designed to be a robust and cost-effective method. It separates ISS planning into two planning functions: long-range planning for a fixed length planning horizon which continually moves forward as ISS operations progress, and short-range planning which takes a small segment of the long-range plan and develops a detailed operations schedule. The continuous approach is compared with the incremental approach, the short and long-range planning functions are described, and the benefits and challenges of implementing a continuous operations planning approach for the ISS are summarized.

The Galaxy Plan in Industrial Education. [Materials] Developed in The Experienced Teacher Fellowship Program.

ERIC Educational Resources Information Center

McClea, Kenneth R., Ed.; And Others

These materials inform school administrators of the rationale of the Detroit Galaxy Plan and provide procedures for implementing the Plan. This program of occupational education for secondary Grades 7 through 12 is planned for students who intend to enter college, apprenticeships, or employment after high school. The Plan, developed by 24…

Five Year Strategic Plan, 1993-1997, Lakeland Community College.

ERIC Educational Resources Information Center

Lakeland Community Coll., Mentor, OH.

In 1990, the newly formed Planning Advisory Committee at Lakewood Community College (LCC) in Mentor, Ohio, developed the college's first 5-year strategic plan with input from across the campus. This plan for 1993-97 updates the original 1990-95 plan and is designed to assist in the development of annual goals and objectives. Following an…

Heat flow in chains driven by thermal noise

NASA Astrophysics Data System (ADS)

Fogedby, Hans C.; Imparato, Alberto

2012-04-01

We consider the large deviation function for a classical harmonic chain composed of N particles driven at the end points by heat reservoirs, first derived in the quantum regime by Saito and Dhar (2007 Phys. Rev. Lett. 99 180601) and in the classical regime by Saito and Dhar (2011 Phys. Rev. E 83 041121) and Kundu et al (2011 J. Stat. Mech. P03007). Within a Langevin description we perform this calculation on the basis of a standard path integral calculation in Fourier space. The cumulant generating function yielding the large deviation function is given in terms of a transmission Green's function and is consistent with the fluctuation theorem. We find a simple expression for the tails of the heat distribution, which turns out to decay exponentially. We, moreover, consider an extension of a single-particle model suggested by Derrida and Brunet (2005 Einstein Aujourd'hui (Les Ulis: EDP Sciences)) and discuss the two-particle case. We also discuss the limit for large N and present a closed expression for the cumulant generating function. Finally, we present a derivation of the fluctuation theorem on the basis of a Fokker-Planck description. This result is not restricted to the harmonic case but is valid for a general interaction potential between the particles.

An updated checklist of mosquito species (Diptera: Culicidae) from Madagascar.

PubMed

Tantely, Michaël Luciano; Le Goff, Gilbert; Boyer, Sébastien; Fontenille, Didier

2016-01-01

An updated checklist of 235 mosquito species from Madagascar is presented. The number of species has increased considerably compared to previous checklists, particularly the last published in 2003 (178 species). This annotated checklist provides concise information on endemism, taxonomic position, developmental stages, larval habitats, distribution, behavior, and vector-borne diseases potentially transmitted. The 235 species belong to 14 genera: Aedeomyia (3 species), Aedes (35 species), Anopheles (26 species), Coquillettidia (3 species), Culex (at least 50 species), Eretmapodites (4 species), Ficalbia (2 species), Hodgesia (at least one species), Lutzia (one species), Mansonia (2 species), Mimomyia (22 species), Orthopodomyia (8 species), Toxorhynchites (6 species), and Uranotaenia (73 species). Due to non-deciphered species complexes, several species remain undescribed. The main remarkable characteristic of Malagasy mosquito fauna is the high biodiversity with 138 endemic species (59%). Presence and abundance of species, and their association, in a given location could be a bio-indicator of environmental particularities such as urban, rural, forested, deforested, and mountainous habitats. Finally, taking into account that Malagasy culicidian fauna includes 64 species (27%) with a known medical or veterinary interest in the world, knowledge of their biology and host preference summarized in this paper improves understanding of their involvement in pathogen transmission in Madagascar. © M.L. Tantely et al., published by EDP Sciences, 2016.

Complete life cycle of a pennellid Peniculus minuticaudae Shiino, 1956 (Copepoda: Siphonostomatoida) infecting cultured threadsail filefish, Stephanolepis cirrhifer.

PubMed

Ismail, Norshida; Ohtsuka, Susumu; Maran, Balu Alagar Venmathi; Tasumi, Satoshi; Zaleha, Kassim; Yamashita, Hirofumi

2013-01-01

The complete life cycle of a pennellid copepod Peniculus minuticaudae Shiino, 1956 is proposed based on the discovery of all post-embryonic stages together with the post-metamorphic adult females infecting the fins of threadsail filefish Stephanolepis cirrhifer (Monacanthidae) cultured in a fish farm at Ehime Prefecture, Japan. The hatching stage was the infective copepodid. The life cycle of P. minuticaudae consists of six stages separated by moults: the copepodid, four chalimi and adult. In this study, the adult males were observed frequently in precopulatory amplexus with various stages of females however, copulation occurs only between adults. Fertilized pre-metamorphic adult females carrying spermatophores may detach from the host and settle again before undergoing massive differential growth into the post-metamorphic adult female. Comparison of the life cycle of P. minuticaudae has been made with three known pennellids: Lernaeocera branchialis (Linnaeus, 1767), Cardiodectes medusaeus (Wilson, 1908) and Lernaeenicus sprattae (Sowerby, 1806). Among the compared species, P. minuticaudae is the first ectoparasitic pennellid to be discovered to complete its life cycle on a single host without any change in infection site preferences between infective copepodid and fertilized pre-metamorphic female. © N. Ismail et al., published by EDP Sciences, 2013.

Echinococcus multilocularis in North America: the great unknown.

PubMed

Massolo, Alessandro; Liccioli, Stefano; Budke, Christine; Klein, Claudia

2014-01-01

Over the last decade, studies have begun to shed light on the distribution and genetic characterization of Echinococcus multilocularis, the causative agent of alveolar echinococcosis (AE), in North America. Recent findings indicate that the parasite is likely expanding its range in the central region of the United States and Canada and that invasions of European strains might have occurred. In our review, we present the available data on E. multilocularis infections in wild and domestic animals and humans in North America and emphasize the lack of knowledge on the distribution of the parasite in wild and domestic hosts. Furthermore, we stress the need to better understand the complexity of host communities and their roles in shaping the transmission and distribution of the parasite. We hypothesize that a lack of knowledge about AE by North American physicians might result in the misdiagnosis of cases and an underestimation of disease incidence. The endemic presence of the parasite in urban areas and a recent human case in Alberta, Canada, suggest that the scientific community may need to reconsider the local public health risks, re-assess past cases that might have been overlooked and increase surveillance efforts to identify new cases of human AE. © A. Massolo et al., published by EDP Sciences, 2014.

Entrance and exit dose measurements with semiconductors and thermoluminescent dosemeters: a comparison of methods and in vivo results.

PubMed

Loncol, T; Greffe, J L; Vynckier, S; Scalliet, P

1996-11-01

In order to compare diodes and TLD for in vivo dosimetry, systematic measurements of entrance and exit doses were performed with semiconductor detectors and thermoluminescent dosemeters for brain and head and neck patients treated isocentrically with external photon beam therapy. Scanditronix EDP-20 diodes and 7LiF thermoluminescent chips, irradiated in a 8 MV linac, were studied with similar build-up cap geometries and materials in order to assure an equivalent electronic equilibrium. Identical calibration methodology was applied to both detectors for the dose determination in clinical conditions. For the entrance dose evaluation over 249 field measurements, the ratio of the measured dose to the expected dose, calculated from tabulated tissue maximum ratios, was equal to 1.010 +/- 0.028 (1 s.d.) from diodes and 1.013 +/- 0.041 from thermoluminescent crystals. For the exit dose measurements, these ratios were equal to 0.998 +/- 0.049 and 1.016 +/- 0.070 for diodes and TLDs, respectively, after application of a simple inhomogeneity correction to the calculation of the expected exit dose. Thermoluminescence and semiconductors led to identical results for entrance and exit dose evaluation but TLDs were characterised by a lower reproducibility inherent to the TL process itself and to the acquisition and annihilation procedures.

Efficacy of a topical application of Certifect® (fipronil 6.26% w/v, amitraz 7.48% w/v, (S)-methoprene 5.63% w/v) for the treatment of canine generalized demodicosis.

PubMed

Fourie, Josephus; Dumont, Pascal; Halos, Lénaïg; Beugnet, Frederic; Pollmeier, Matthias

2013-01-01

The efficacy of the treatment with Certifect ® (containing fipronil 6.26% w/v, amitraz 7.48% w/v, (S)-methoprene 5.63% w/v) applied topically was assessed in 18 dogs diagnosed with clinical generalized demodicosis. Three treatment regimens were compared over a 3-month period. Starting at Day 0, dogs were treated monthly (group 1) or every two weeks (group 2) with the combination of fipronil, amitraz, and (S)-methoprene or with monthly topical applications of the combination of amitraz and metaflumizone (group 3, reference treatment). Clinical examinations including deep skin scrapings were performed every month in order to evaluate the resolution of clinical signs and the reduction in mite counts. On Day 84, the percentage reduction of mite counts in group 1 was 99.8%, whereas no Demodex canis could be detected in groups 2 and 3 (i.e. 100% parasitological efficacy). As a result of the Demodex mite count reduction, the skin condition of the dogs improved significantly in all groups. This study illustrates, that both monthly and bi-weekly treatments with Certifect were effective in treating dogs with generalized demodicosis over a 3-month period. © J. Fourie et al., published by EDP Sciences, 2013.

Heat induced generation of the mitogenic substance(s) responding to murine splenocytes obtained from sclerotia of Sclerotinia sclerotiorum IFO 9395.

PubMed

Shinohara, H; Ohno, N; Yadomae, T

1990-08-01

We have demonstrated that hot water extracts of sclerotia of Sclerotinia sclerotiorum IFO 9395 (TSHW) show various immunomodulating activities and mitogenic substance(s) were recovered from the beta-1,3-glucanase resistant-fraction (EDP) (Shinohara et al. Chem. Pharm. Bull., 37, 2174 (1989]. In this paper, we examined whether or not the mitogenic substance(s) were also obtained from the other methods, phosphate buffer extraction. Although the native extracts (3S-M) sterilized with a membrane filter showed a slight mitogenicity to murine splenocytes, 3S-M denatured in boiling water (3S-MB) showed significant activity. Treatment of 3S-M for only 1 min in boiling water or 10 min at 70 degrees C was sufficient to show significant mitogenic activity. After heat treatment of 3S-M in boiling water for 30 s, the main band corresponding to that of 3S-M was not clearly observed. Instead, new bands appeared at the top of the gel in normal-polyacrylamide gel electrophoresis (normal-PAGE), suggesting that many physicochemical changes occurred during the heat treatment. These findings suggest that heat denaturation of the substance(s) from sclerotia was one of the triggering mechanisms expressing mitogenic activity to murine splenocytes.

Orthopedic surgeons' knowledge regarding risk of radiation exposition: a survey analysis.

PubMed

Tunçer, Nejat; Kuyucu, Ersin; Sayar, Şafak; Polat, Gökhan; Erdil, İrem; Tuncay, İbrahim

2017-01-01

The purpose of this study is to evaluate the knowledge levels of orthopedic surgeons working in Turkey about the uses and possible risks of fluoroscopy and assess methods for preventing radiation damage. A questionnaire with a total of 12 questions was sent to 1121 orthopedic surgeons working in Turkey. The questionnaire evaluated participants' knowledge about the uses and risks of fluoroscopy and methods for preventing damage. One thousand and twenty-four orthopedic surgeons were found to be suitable for inclusion in the study. The effects of fluoroscopy on patients were not assessed in our study. The data obtained were statistically evaluated. Of the surveyed surgeons, 313 (30%) had used fluoroscopy in over 50% of their operations. The average number of fluoroscopy shots per case was 54.5. A lead apron was the most commonly used (88%) protection from the harmful effects of radiation. Fluoroscopy shots were performed with the help of operating room personnel (86%). A dosimeter was used 5% of the time. According to the survey results, the need for fluoroscopy was very high in orthopedic surgery. However, orthopedic surgeons have inadequate knowledge about the uses and risks of fluoroscopy and methods for preventing damage. Therefore, we believe that training on this topic should be provided to all orthopedic surgeons. © The Authors, published by EDP Sciences, 2017.

Method for forming suspended micromechanical structures

DOEpatents

Fleming, James G.

2000-01-01

A micromachining method is disclosed for forming a suspended micromechanical structure from {111} crystalline silicon. The micromachining method is based on the use of anisotropic dry etching to define lateral features of the structure which are etched down into a {111}-silicon substrate to a first etch depth, thereby forming sidewalls of the structure. The sidewalls are then coated with a protection layer, and the substrate is dry etched to a second etch depth to define a spacing of the structure from the substrate. A selective anisotropic wet etchant (e.g. KOH, EDP, TMAH, NaOH or CsOH) is used to laterally undercut the structure between the first and second etch depths, thereby forming a substantially planar lower surface of the structure along a {111} crystal plane that is parallel to an upper surface of the structure. The lateral extent of undercutting by the wet etchant is controlled and effectively terminated by either timing the etching, by the location of angled {111}-silicon planes or by the locations of preformed etch-stops. This present method allows the formation of suspended micromechanical structures having large vertical dimensions and large masses while allowing for detailed lateral features which can be provided by dry etch definition. Additionally, the method of the present invention is compatible with the formation of electronic circuitry on the substrate.

The Golden jackal (Canis aureus) as an indicator animal for Trichinella britovi in Iran.

PubMed

Shamsian, Aliakbar; Pozio, Edoardo; Fata, Abdolmajid; Navi, Zahra; Moghaddas, Elham

2018-01-01

Nematodes of the genus Trichinella are zoonotic parasites causing trichinellosis. In Iran, these parasites occur in several animal species and rare cases have been recorded in humans. To monitor the epidemiological pattern of these parasites in the Khorasan-e-Razavi province, Northeastern Iran, muscle tissues were collected from the tongues of roadkill animals between 2016 and 2017: 295 stray dogs, one red fox (Vulpes vulpes), 12 golden jackals (Canis aureus), and one wild boar (Sus scrofa). Trichinella spp. larvae were retrieved using the artificial digestion method and identified to the species level by multiplex PCR. Larvae identified as Trichinella britovi were detected in five stray dogs (1.7%) and one golden jackal (8.3%). The results confirm the circulation of T. britovi in animals of the Khorasan-e-Razavi province, as previously documented. A review of the literature on Trichinella spp. in animals in Iran showed that these parasites were previously detected in 20.02% and 0.04% of carnivore and omnivore mammals, respectively, and that golden jackals can be screened as indicator animals for these zoonotic nematodes. Convenient sampling of Trichinella susceptible roadkill animals may provide a suitable method of monitoring the circulation of these parasites within any given region. © A. Shamsian et al., published by EDP Sciences, 2018.

The Poisson-Helmholtz-Boltzmann model.

PubMed

Bohinc, K; Shrestha, A; May, S

2011-10-01

We present a mean-field model of a one-component electrolyte solution where the mobile ions interact not only via Coulomb interactions but also through a repulsive non-electrostatic Yukawa potential. Our choice of the Yukawa potential represents a simple model for solvent-mediated interactions between ions. We employ a local formulation of the mean-field free energy through the use of two auxiliary potentials, an electrostatic and a non-electrostatic potential. Functional minimization of the mean-field free energy leads to two coupled local differential equations, the Poisson-Boltzmann equation and the Helmholtz-Boltzmann equation. Their boundary conditions account for the sources of both the electrostatic and non-electrostatic interactions on the surface of all macroions that reside in the solution. We analyze a specific example, two like-charged planar surfaces with their mobile counterions forming the electrolyte solution. For this system we calculate the pressure between the two surfaces, and we analyze its dependence on the strength of the Yukawa potential and on the non-electrostatic interactions of the mobile ions with the planar macroion surfaces. In addition, we demonstrate that our mean-field model is consistent with the contact theorem, and we outline its generalization to arbitrary interaction potentials through the use of a Laplace transformation. © EDP Sciences / Società Italiana di Fisica / Springer-Verlag 2011

13 CFR 303.9 - Requirements for short-term Planning Investments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Planning Investments. 303.9 Section 303.9 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PLANNING INVESTMENTS AND COMPREHENSIVE ECONOMIC DEVELOPMENT STRATEGIES § 303.9 Requirements for short-term Planning Investments. (a) In addition to providing support for CEDS...

13 CFR 303.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 303.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PLANNING INVESTMENTS AND COMPREHENSIVE ECONOMIC DEVELOPMENT STRATEGIES § 303.1 Purpose and scope. The purpose of EDA Planning Investments is to provide support to Planning Organizations for the development...

7 CFR 1948.53 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... program. (l) Growth management planning. Planning for the orderly development of an approved designated... services needed; overall plans for the coordinated development of all approved designated areas within a... identification of: housing sites; housing site development needs; data and resource needs; funding needs...

7 CFR 1948.53 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... program. (l) Growth management planning. Planning for the orderly development of an approved designated... services needed; overall plans for the coordinated development of all approved designated areas within a... identification of: housing sites; housing site development needs; data and resource needs; funding needs...

7 CFR 1948.53 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... program. (l) Growth management planning. Planning for the orderly development of an approved designated... services needed; overall plans for the coordinated development of all approved designated areas within a... identification of: housing sites; housing site development needs; data and resource needs; funding needs...

Planning Construction Research of Modern Urban Landscape

NASA Astrophysics Data System (ADS)

Xiao, Z. Q.; Chen, W.

With the development and expansion of the city's traditional urban landscape planning methods have been difficult to adapt to the requirements of modern urban development, in the new urban construction, planning what kind of urban landscape is a new research topic. The article discusses the principles of modern urban landscape planning and development, promote the adoption of new concepts and theories, building more regional characteristics, more humane, more perfect, more emphasis on urban landscape pattern natural ecological protection and construction can sustainable development of urban living environment, and promote the development and construction of the city.

36 CFR 910.59 - Development parcel.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE... goals of comprehensive planning and design for that particular coordinated planning area. ...

36 CFR 910.59 - Development parcel.

Code of Federal Regulations, 2011 CFR

2011-07-01

... GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE... goals of comprehensive planning and design for that particular coordinated planning area. ...

Anticipatory Action Planning Increases from 3 to 10 Years of Age in Typically Developing Children

ERIC Educational Resources Information Center

Jongbloed-Pereboom, Marjolein; Nijhuis-van der Sanden, Maria W. G.; Saraber-Schiphorst, Nicole; Craje, Celine; Steenbergen, Bert

2013-01-01

The primary aim of this study was to assess the development of action planning in a group of typically developing children aged 3 to 10 years (N = 351). The second aim was to assess reliability of the action planning task and to relate the results of the action planning task to results of validated upper limb motor performance tests. Participants…

Achieving Success in Small Business. A Self-Instruction Program for Small Business Owner-Managers. Developing Your Sales Promotion Plan.

ERIC Educational Resources Information Center

Virginia Polytechnic Inst. and State Univ., Blacksburg. Div. of Vocational-Technical Education.

This self-instructional module on developing your sales promotion plan is the fifth in a set of twelve modules designed for small business owner-managers. Competencies for this module are (1) describe the role of advertising, display, and personal selling in a sales promotion plan and (2) develop an effective sales promotion plan which…

Geospatial Based Information System Development in Public Administration for Sustainable Development and Planning in Urban Environment

NASA Astrophysics Data System (ADS)

Kouziokas, Georgios N.

2016-09-01

It is generally agreed that the governmental authorities should actively encourage the development of an efficient framework of information and communication technology initiatives so as to advance and promote sustainable development and planning strategies. This paper presents a prototype Information System for public administration which was designed to facilitate public management and decision making for sustainable development and planning. The system was developed by using several programming languages and programming tools and also a Database Management System (DBMS) for storing and managing urban data of many kinds. Furthermore, geographic information systems were incorporated into the system in order to make possible to the authorities to deal with issues of spatial nature such as spatial planning. The developed system provides a technology based management of geospatial information, environmental and crime data of urban environment aiming at improving public decision making and also at contributing to a more efficient sustainable development and planning.

Locate, Plan, Develop, Use An Outdoor Classroom.

ERIC Educational Resources Information Center

Soil Conservation Service (USDA), Upper Darby, PA.

Designed to aid educational institutions and community organizations in selecting, planning, developing and using outdoor learning areas as outdoor classrooms, this guide includes: (1) Learning by Discovery (scientific, cultural, and recreational goals); (2) The Initial Planning Effort (use of: a planning committee including teachers,…

75 FR 20783 - Approval and Promulgation of Implementation Plans: Tennessee; Visibility Impairment Prevention...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-21

...-2010-0150,'' Regulatory Development Section, Air Planning Branch, Air, Pesticides and Toxics Management... Planning Branch, Air, Pesticides and Toxics Management Division, U.S. Environmental Protection Agency... at the Regulatory Development Section, Air Planning Branch, Air, Pesticides and Toxics Management...

Bibliography on Life/Career Planning.

ERIC Educational Resources Information Center

Snyder, Jane

Developed for use in a university life/career planning course, this bibliography applies the principles of business management to personal and occupational planning and career development. The first part of the document contains the model for life/career planning which includes student activities in decisionmaking, personal and environmental…

24 CFR 582.120 - Consolidated plan.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES SHELTER PLUS CARE Assistance Provided § 582.120 Consolidated plan. (a... is required to have, or has, a complete consolidated plan, or that is applying for Shelter Plus Care...

44 CFR 78.5 - Flood Mitigation Plan development.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Flood Mitigation Plan..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION ASSISTANCE § 78.5 Flood Mitigation Plan development. A Flood Mitigation Plan will articulate a...

44 CFR 78.5 - Flood Mitigation Plan development.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Flood Mitigation Plan..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION ASSISTANCE § 78.5 Flood Mitigation Plan development. A Flood Mitigation Plan will articulate a...

44 CFR 78.5 - Flood Mitigation Plan development.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Flood Mitigation Plan..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION ASSISTANCE § 78.5 Flood Mitigation Plan development. A Flood Mitigation Plan will articulate a...

The Design and Development of an Intelligent Planning Aid

DTIC Science & Technology

1986-07-01

reasons why widening the scope of TACPLAK’s applicability make sense. First# plan execution and monitoring (and the re-planning that then occurs) are...Orsssnu, contracting officer’s representative I», KKY voees o Decision Making Tactical Planning Taxonomy Problem Solving ii M ifrntitr *r MM* I...planning aid. It documents the development of a decision- making , planning, and decision-aiding analytical framework comprising a set of models, s generic

Development and clinical introduction of automated radiotherapy treatment planning for prostate cancer

NASA Astrophysics Data System (ADS)

Winkel, D.; Bol, G. H.; van Asselen, B.; Hes, J.; Scholten, V.; Kerkmeijer, L. G. W.; Raaymakers, B. W.

2016-12-01

To develop an automated radiotherapy treatment planning and optimization workflow to efficiently create patient specifically optimized clinical grade treatment plans for prostate cancer and to implement it in clinical practice. A two-phased planning and optimization workflow was developed to automatically generate 77Gy 5-field simultaneously integrated boost intensity modulated radiation therapy (SIB-IMRT) plans for prostate cancer treatment. A retrospective planning study (n  =  100) was performed in which automatically and manually generated treatment plans were compared. A clinical pilot (n  =  21) was performed to investigate the usability of our method. Operator time for the planning process was reduced to  <5 min. The retrospective planning study showed that 98 plans met all clinical constraints. Significant improvements were made in the volume receiving 72Gy (V72Gy) for the bladder and rectum and the mean dose of the bladder and the body. A reduced plan variance was observed. During the clinical pilot 20 automatically generated plans met all constraints and 17 plans were selected for treatment. The automated radiotherapy treatment planning and optimization workflow is capable of efficiently generating patient specifically optimized and improved clinical grade plans. It has now been adopted as the current standard workflow in our clinic to generate treatment plans for prostate cancer.

24. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass, Climatic Building, First Floor Plan, Architectural. Drawing No. 35-07-01, Sheet 2 of 72, 1952, updated to 1985. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

40 CFR 109.5 - Development and implementation criteria for State, local and regional oil removal contingency plans.

Code of Federal Regulations, 2012 CFR

2012-07-01

... OIL REMOVAL CONTINGENCY PLANS § 109.5 Development and implementation criteria for State, local and regional oil removal contingency plans. Criteria for the development and implementation of State, local and... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Development and implementation...

Education and Modernization of Micronesia: A Case Study in Development and Development Planning.

ERIC Educational Resources Information Center

Pearse, Richard; Bezanson, Keith A.

The case study examined the development of an overall education plan for the Trust Territory of the Pacific Islands. The methodology of multidisciplinary education planning through the use of general comparative analysis models of political, economic, and social development is explained: Almond and Powell's framework for the analysis of political…

25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass. Climatic Building, First Floor Plan, Refrigeration and Engineering. Drawing No. 35-07-01, Sheet 52 of 72, 1952. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

77 FR 31974 - Order of Succession for the Office of Community Planning and Development

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5642-D-02] Order of Succession for the Office of Community Planning and Development AGENCY: Office of the Secretary, HUD. ACTION: Notice of Order of Succession for the Office of Community Planning and Development. SUMMARY: In this notice, the...

77 FR 38851 - Redelegation of Authority to Directors and Deputy Directors of Community Planning and Development...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Assistance and Management, Office of Community Planning and Development, Department of Housing and Urban... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5642-D-04] Redelegation of Authority to Directors and Deputy Directors of Community Planning and Development in Field Offices AGENCY: Office of the...

76 FR 64364 - Order of Succession for the Office of Community Planning and Development

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-18

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5556-D-02] Order of Succession for the Office of Community Planning and Development AGENCY: Office of the Assistant Secretary for Community Planning and Development, HUD. ACTION: Notice of Order of Succession. SUMMARY: In this notice, the...

DEVELOPMENT OF A MULTIMODAL MONTE CARLO BASED TREATMENT PLANNING SYSTEM.

PubMed

Kumada, Hiroaki; Takada, Kenta; Sakurai, Yoshinori; Suzuki, Minoru; Takata, Takushi; Sakurai, Hideyuki; Matsumura, Akira; Sakae, Takeji

2017-10-26

To establish boron neutron capture therapy (BNCT), the University of Tsukuba is developing a treatment device and peripheral devices required in BNCT, such as a treatment planning system. We are developing a new multimodal Monte Carlo based treatment planning system (developing code: Tsukuba Plan). Tsukuba Plan allows for dose estimation in proton therapy, X-ray therapy and heavy ion therapy in addition to BNCT because the system employs PHITS as the Monte Carlo dose calculation engine. Regarding BNCT, several verifications of the system are being carried out for its practical usage. The verification results demonstrate that Tsukuba Plan allows for accurate estimation of thermal neutron flux and gamma-ray dose as fundamental radiations of dosimetry in BNCT. In addition to the practical use of Tsukuba Plan in BNCT, we are investigating its application to other radiation therapies. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

24 CFR 91.5 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS General § 91.5 Definitions. The terms..., community development plan, and submissions for funding under any of the Community Planning and Development... domestic violence, youth, and persons with HIV/AIDS. Jurisdiction. A State or unit of general local...

Low Impact Development Master Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loftin, Samuel R.

This project creates a Low Impact Development (LID) Master Plan to guide and prioritize future development of LID projects at Los Alamos National Laboratory (LANL or the Laboratory). The LID Master Plan applies to developed areas across the Laboratory and focuses on identifying opportunities for storm water quality and hydrological improvements in the heavily urbanized areas of Technical Areas 03, 35 and 53. The LID Master Plan is organized to allow the addition of LID projects for other technical areas as time and funds allow in the future.

Montana geothermal commercialization planning. Semi-annual progress report, January 1, 1979-June 30, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Birkby, J.; Brown, K.; Chapman, M.

1979-06-01

Area development plans were prepared which describe geothermal resources and their potential use on a county or multicounty basis. Development plans for two areas are presented. Cost analyses show that the proximity of the geothermal resource to the end user is the most important criterion in geothermal energy development. Thirteen tentative site-specific plans are being revised. The analysis of institutional factors affecting geothermal development, the outreach, and the state geothermal are discussed briefly. (MHR)

A Plan for the Development and Demonstration of Optical Communications for Deep Space

NASA Technical Reports Server (NTRS)

Lesh, J. R.; Deutsch, L. J.; Weber, W. J.

1990-01-01

In this article, an overall plan for the development and demonstration of optical communications for deep-space applications is presented. The current state of the technology for optical communications is presented. Then, the development and demonstration plan is presented in two parts: the overall major systems activities, followed by the generic technology developments that will enable them. The plan covers the path from laboratory subsystems demonstrations out to a full-scale flight experiment system for the proposed Mars Communications Relay Orbiter mission.

Strategic Planning and Doctor Of Nursing Practice Education: Developing Today's and Tomorrow's Leaders.

PubMed

Falk, Nancy L; Garrison, Kenneth F; Brown, Mary-Michael; Pintz, Christine; Bocchino, Joseph

2015-01-01

Strategic planning and thinking skills are essential for today's nurse leaders. Doctor of nursing practice (DNP) programs provide an opportunity for developing effective nurse strategists. A well-designed strategy course can stimulate intellectual growth at all levels of Bloom's Taxonomy. Discussion forums in online education provide new opportunities for rich interaction among peers en route to development of well-informed strategic plans. An interprofessional perspective adds a rich and vital aspect to doctoral nursing education and it serves to inform strategic plan development. A roadmap for teaching strategic planning to current and future nursing leaders will guide the integration of essential content into DNP programs.

The Missouri Career Development and Teacher Excellence Plan: An Initial Study of Missouri's Career Ladder Program. A Technical Report.

ERIC Educational Resources Information Center

Schofer, Richard C.; And Others

The Missouri Plan provides for direct participation of teachers in the planning, development, and implementation of the district career ladder plan. This study analyzed the appropriateness of the Missouri teacher incentive plan. In particular, the study sought to determine why districts did or did not choose to implement career ladder programs;…