Advanced Automotive Diesel Assessment Program, executive summary

NASA Technical Reports Server (NTRS)

1983-01-01

The objectives of this analytical study were: to select one advanced automotive diesel engine (AAD) concept which would increase the tank mileage of a 3,000 pound passenger car from the present 35 mpg to at least 52 mpg; to identify long term component research and development work required to bring the selected concept to fruition; and to prepare a development strategy that will bring the selected concept to a prototype testing phase. Cummins Engine Company has completed this study. The selected concept is a 4 stroke cycle, direct injection, spark assisted, advanced adiabatic diesel engine with positive displacement compounding plus expander and part load air preheating. The engine does not use a liquid coolant nor liquid lubricants. It is a 4 cylinder, in-line, 77 mm bore x 77 mm stroke, 1.434 liters displacement engine weighing 300 lb, and rated at 70 BHP at 3000 rpm. Installation dimensions are 621 mm length x 589 mm width x 479 mm height (24.4 inch x 22 inch x 18.9 inch).

No Evidence from FTIR Difference Spectroscopy that Glutamate-189 of the D1 Polypeptide Ligates a Mn Ion that Undergoes Oxidation During the S0 to S1, S1 to S2, or S2 to S3 Transitions in Photosystem II†

PubMed Central

Strickler, Melodie A.; Hillier, Warwick; Debus, Richard J.

2008-01-01

In the recent X-ray crystallographic structural models of photosystem II, Glu189 of the D1 polypeptide is assigned as a ligand of the oxygen-evolving Mn4 cluster. To determine if D1-Glu189 ligates a Mn ion that undergoes oxidation during one or more of the S0 → S1, S1 → S2, and S2 → S3 transitions, the FTIR difference spectra of the individual S state transitions in D1-E189Q and D1-E189R mutant PSII particles from the cyanobacterium Synechocystis sp. PCC 6803 were compared with those in wild-type PSII particles. Remarkably, the data show that neither mutation significantly alters the mid-frequency regions (1800 − 1200 cm−1) of any of the FTIR difference spectra. Importantly, neither mutation eliminates any specific symmetric or asymmetric carboxylate stretching mode that might have been assigned to D1-Glu189. The small spectral alterations that are observed are similar in amplitude to those that are observed in wild-type PSII particles that have been exchanged into FTIR analysis buffer by different methods or those that are observed in D2-H189Q mutant PSII particles (the residue D2-His189 is located > 25 Å from the Mn4 cluster and accepts a hydrogen bond from Tyr YD). The absence of significant mutation-induced spectral alterations in the D1-Glu189 mutants shows that the oxidation of the Mn4 cluster does not alter the frequencies of the carboxylate stretching modes of D1-Glu189 during the S0 → S1, S1 → S2, or S2 → S3 transitions. One explanation of these data is that D1-Glu189 ligates a Mn ion that does not increase its charge or oxidation state during any of these S state transitions. However, because the same conclusion was reached previously for D1-Asp170, and because the recent X-ray crystallographic structural models assign D1-Asp170 and D1-Glu189 as ligating different Mn ions, this explanation requires that (1) the extra positive charge that develops on the Mn4 cluster during the S1 → S2 transition be localized on the Mn ion that is ligated by the α-COO− group of D1-Ala344 and (2) any increase in positive charge that develops on the Mn4 cluster during the S0 → S1 and S2 → S3 transitions be localized on the one Mn ion that is not ligated by D1-Asp170, D1-Glu189, or D1-Ala344. An alternative explanation of the FTIR data is that D1-Glu189 does not ligate the Mn4 cluster. This conclusion would be consistent with earlier spectroscopic analyses of D1-Glu189 mutants, but would require that the proximity of D1-Glu189 to manganese in the X-ray crystallographic structural models be an artifact of the radiation-induced reduction of the Mn4 cluster that occurred during the collection of the X-ray diffraction data. PMID:16846223

Nuclear Data Sheets for A=189

DOE PAGES

Johnson, T. D.; Singh, Balraj

2017-04-26

Evaluated experimental data are presented for 13 known mass 189 nuclides (Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po). Since the 2003Wu02 publication, structure and decay data from 25 new and primary publications have been incorporated in the current work, while adding a new 189Hf nuclide. New data have been added for all nuclides except 189Au and 189Hg. Moreover, several previous datasets were modified for β-decay Q values and conversion coefficients even when no new publications appeared since 2003Wu02. In spite of large amounts of data available for A=189 nuclides, several deficiencies remain, which aremore » pointed out below in the hope that further experimental work may improve our knowledge of structure of these nuclides. For 189Hf and 189Ta, ground-state half-lives, and their decay schemes are unknown. An isomer in 189Ta has recently been established but its decay characteristics are unknown, even though several gamma rays were connected with its decay. No excited states are known in 189W and only one in 189Po. The decay scheme of 189W is known poorly with most gamma rays left as unassigned. The decay schemes of 189Au and 189Pb g.s. suffer from incompleteness, while those for the g.s. and isomer of 189Tl are almost absent. The decay schemes of g.s. and isomer of 189Hg are very complex as apparent from the study by 1996Wo04. Evaluators feel that these two decay schemes could be improved with modern gamma-ray detector arrays. While several isomers are known in many of the A=189 nuclides, there is in general lack of information of level half-lives, thus limiting the knowledge of transition probabilities. High-spin structures, including SD bands in 189Hg and 189Tl, are known in 189Re, 189Ir, 189Pt, 189Au, 189Hg, 189Tl, 189Pb and 189Bi. Single-particle transfer data are available for 189Re, 189Os, and 189Pt; and two-neutron transfer data for 189Ir.« less

Nuclear Data Sheets for A=189

NASA Astrophysics Data System (ADS)

Johnson, T. D.; Singh, Balraj

2017-05-01

Evaluated experimental data are presented for 13 known mass 189 nuclides (Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po). Since the 2003Wu02 publication, structure and decay data from 25 new and primary publications have been incorporated in the current work, while adding a new 189Hf nuclide. New data have been added for all nuclides except 189Au and 189Hg. Moreover, several previous datasets were modified for β-decay Q values and conversion coefficients even when no new publications appeared since 2003Wu02. In spite of large amounts of data available for A=189 nuclides, several deficiencies remain, which are pointed out below in the hope that further experimental work may improve our knowledge of structure of these nuclides. For 189Hf and 189Ta, ground-state half-lives, and their decay schemes are unknown. An isomer in 189Ta has recently been established but its decay characteristics are unknown, even though several gamma rays were connected with its decay. No excited states are known in 189W and only one in 189Po. The decay scheme of 189W is known poorly with most gamma rays left as unassigned. The decay schemes of 189Au and 189Pb g.s. suffer from incompleteness, while those for the g.s. and isomer of 189Tl are almost absent. The decay schemes of g.s. and isomer of 189Hg are very complex as apparent from the study by 1996Wo04. Evaluators feel that these two decay schemes could be improved with modern gamma-ray detector arrays. While several isomers are known in many of the A=189 nuclides, there is in general lack of information of level half-lives, thus limiting the knowledge of transition probabilities. High-spin structures, including SD bands in 189Hg and 189Tl, are known in 189Re, 189Ir, 189Pt, 189Au, 189Hg, 189Tl, 189Pb and 189Bi. Single-particle transfer data are available for 189Re, 189Os, and 189Pt; and two-neutron transfer data for 189Ir.

Nuclear Data Sheets for A=189

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, T. D.; Singh, Balraj

Evaluated experimental data are presented for 13 known mass 189 nuclides (Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po). Since the 2003Wu02 publication, structure and decay data from 25 new and primary publications have been incorporated in the current work, while adding a new 189Hf nuclide. New data have been added for all nuclides except 189Au and 189Hg. Moreover, several previous datasets were modified for β-decay Q values and conversion coefficients even when no new publications appeared since 2003Wu02. In spite of large amounts of data available for A=189 nuclides, several deficiencies remain, which aremore » pointed out below in the hope that further experimental work may improve our knowledge of structure of these nuclides. For 189Hf and 189Ta, ground-state half-lives, and their decay schemes are unknown. An isomer in 189Ta has recently been established but its decay characteristics are unknown, even though several gamma rays were connected with its decay. No excited states are known in 189W and only one in 189Po. The decay scheme of 189W is known poorly with most gamma rays left as unassigned. The decay schemes of 189Au and 189Pb g.s. suffer from incompleteness, while those for the g.s. and isomer of 189Tl are almost absent. The decay schemes of g.s. and isomer of 189Hg are very complex as apparent from the study by 1996Wo04. Evaluators feel that these two decay schemes could be improved with modern gamma-ray detector arrays. While several isomers are known in many of the A=189 nuclides, there is in general lack of information of level half-lives, thus limiting the knowledge of transition probabilities. High-spin structures, including SD bands in 189Hg and 189Tl, are known in 189Re, 189Ir, 189Pt, 189Au, 189Hg, 189Tl, 189Pb and 189Bi. Single-particle transfer data are available for 189Re, 189Os, and 189Pt; and two-neutron transfer data for 189Ir.« less

Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction.

PubMed

Nawroth, Frank; Tandler-Schneider, Andreas; Bilger, Wilma

2015-01-01

This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH) using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic and undergoing ovulation induction (OI) alone or OI with intrauterine insemination. The primary endpoint was the proportion of patients who achieved monofollicular or bifollicular development (defined as one or two follicles ≥15 mm). Secondary endpoints included characteristics of ovulation stimulation treatment, such as mean total and mean daily r-hFSH doses. Data were analyzed for 3,193 patients from 30 German fertility centers. The proportion of patients with monofollicular or bifollicular development was 71.1% (n=2,270 of a total of 3,193 patients; intent-to-treat population). The mean±standard deviation total and daily doses of r-hFSH were 696.9±542.5 IU and 61.7±29.4 IU, respectively. The three doses prescribed most frequently were: 37.5 IU (n=703 from N=3,189; 22.0%), 50.0 IU (n=1,056 from N=3,189; 33.1%), and 75.0 IU (n=738 from N=3,189; 23.1%) on the first day of stimulation; and 37.5 IU (n=465 from N=3,189; 14.6%), 50.0 IU (n=922 from N=3,189; 28.9%), and 75.0 IU (n=895 from N=3,189; 28.1%) on the last day of stimulation. This noninterventional, post-marketing surveillance study found that monofollicular or bifollicular development was achieved in 71% of patients studied and the small dose increment (12.5 IU) of the redesigned follitropin alfa pen allowed individualized treatment of women undergoing OI.

Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction

PubMed Central

Nawroth, Frank; Tandler-Schneider, Andreas; Bilger, Wilma

2015-01-01

This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH) using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic and undergoing ovulation induction (OI) alone or OI with intrauterine insemination. The primary endpoint was the proportion of patients who achieved monofollicular or bifollicular development (defined as one or two follicles ≥15 mm). Secondary endpoints included characteristics of ovulation stimulation treatment, such as mean total and mean daily r-hFSH doses. Data were analyzed for 3,193 patients from 30 German fertility centers. The proportion of patients with monofollicular or bifollicular development was 71.1% (n=2,270 of a total of 3,193 patients; intent-to-treat population). The mean±standard deviation total and daily doses of r-hFSH were 696.9±542.5 IU and 61.7±29.4 IU, respectively. The three doses prescribed most frequently were: 37.5 IU (n=703 from N=3,189; 22.0%), 50.0 IU (n=1,056 from N=3,189; 33.1%), and 75.0 IU (n=738 from N=3,189; 23.1%) on the first day of stimulation; and 37.5 IU (n=465 from N=3,189; 14.6%), 50.0 IU (n=922 from N=3,189; 28.9%), and 75.0 IU (n=895 from N=3,189; 28.1%) on the last day of stimulation. This noninterventional, post-marketing surveillance study found that monofollicular or bifollicular development was achieved in 71% of patients studied and the small dose increment (12.5 IU) of the redesigned follitropin alfa pen allowed individualized treatment of women undergoing OI. PMID:25926755

Dollar Summary of Prime Contract Awards by State, Place, and Contractor, FY83, Part 1 (Adamsville, Alabama - Ferndale, Michigan).

DTIC Science & Technology

1983-01-01

ALABAMA 281 281 WESTON ROY F ANNISTON ALABAMA 585- 585- WESTON ROY F & HARRINGTON ETAL JV ANNISTON ALABAMA 52 52 WILLIAMS CONSTRUCTION CO INC ANNISTON...ALABAMA 33 33 ERNEST CONSTRUCTION CO BAY MINETTE ALABAMA 200 200 SYNTEX DENTAL CO BAY MINETTE ALABAMA 2,601 169 2,412 2,925 91 189 2,445 200 QUALITY...ALABAMA 1,235 1,235 WILLIAMS BURT CONST & REMODELNG C FORT RUCKER ALABAMA 160 160 WOODHAM & SHARPE FORT RUCKER ALABAMA 44 44 XEROX CORP FORT RUCKER

Kinase activity of OsBRI1 is essential for brassinosteroids to regulate rice growth and development.

PubMed

Zhao, Jinfeng; Wu, Chenxi; Yuan, Shoujiang; Yin, Liang; Sun, Wei; Zhao, Qinglei; Zhao, Baohua; Li, Xueyong

2013-02-01

Brassinosteroids (BRs) are steroid hormones that participate in multiple biological processes. In this paper, we characterized a classic rice mutant Fn189 (dwarf54, d54) showing semi-dwarf stature and erect leaves. The coleoptile elongation and root growth was less affected in Fn189 than wild-type plant by the exogenous application of eBL, the most active form of BRs. Lamina joint inclination assay and morphological analysis in darkness further showed that Fn189 mutant plant was insensitive to exogenous eBL. Through map-based cloning, Fn189 was found to be a novel allelic mutant of the DWARF 61 (D61) gene, which encodes the putative BRs receptor OsBRI1. A single base mutation caused the I834F substitution in the OsBRI1 kinase domain. Consequently, kinase activity of OsBRI1 was found to decrease dramatically. Taken together, the kinase activity of OsBRI1 is essential for brassinosteroids to regulate normal plant growth and development in rice. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Department of Defense Base Structure Report (A Summary of DoD’s Real Property Inventory). Fiscal Year 2004 Baseline

DTIC Science & Technology

2004-01-01

William T. Fitzsimons USARC Aurora 80045 4 163,390 21 21 32.5303-360-0963Army Reserve Buckley AFB Aurora 80011 157 2,046,358 3,872 3,283 705.7 2,554 419 0...945406-841-3009Army Guard Sgt Ernest Veuve Hall/AMSA #74 Missoula 59801 5 65,353 16 16 13.2 189 6 0 195406-728-0414Army Reserve Malmstrom AFB Augusta...Defense Fuel Support Point Cincinnati 45237 7 3,979 67 66 37.8AF Active Wright Patterson AFB Fairborn 45433 694 15,342,399 8,145 7,631 4,091.9 7,563

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batcheller, Thomas Aquinas; Taylor, Dean Dalton

Idaho Nuclear Technology and Engineering Center 300,000-gallon vessel WM-189 was filled in late 2001 with concentrated sodium bearing waste (SBW). Three airlifted liquid samples and a steam jetted slurry sample were obtained for quantitative analysis and characterization of WM-189 liquid phase SBW and tank heel sludge. Estimates were provided for most of the reported data values, based on the greater of (a) analytical uncertainty, and (b) variation of analytical results between nominally similar samples. A consistency check on the data was performed by comparing the total mass of dissolved solids in the liquid, as measured gravimetrically from a dried sample,more » with the corresponding value obtained by summing the masses of cations and anions in the liquid, based on the reported analytical data. After reasonable adjustments to the nitrate and oxygen concentrations, satisfactory consistency between the two results was obtained. A similar consistency check was performed on the reported compositional data for sludge solids from the steam jetted sample. In addition to the compositional data, various other analyses were performed: particle size distribution was measured for the sludge solids, sludge settling tests were performed, and viscosity measurements were made. WM-189 characterization results were compared with those for WM-180, and other Tank Farm Facility tank characterization data. A 2-liter batch of WM-189 simulant was prepared and a clear, stable solution was obtained, based on a general procedure for mixing SBW simulant that was develop by Dr. Jerry Christian. This WM-189 SBW simulant is considered suitable for laboratory testing for process development.« less

Advanced ETC/LSS computerized analytical models, CO2 concentration. Volume 1: Summary document

NASA Technical Reports Server (NTRS)

Taylor, B. N.; Loscutoff, A. V.

1972-01-01

Computer simulations have been prepared for the concepts of C02 concentration which have the potential for maintaining a C02 partial pressure of 3.0 mmHg, or less, in a spacecraft environment. The simulations were performed using the G-189A Generalized Environmental Control computer program. In preparing the simulations, new subroutines to model the principal functional components for each concept were prepared and integrated into the existing program. Sample problems were run to demonstrate the methods of simulation and performance characteristics of the individual concepts. Comparison runs for each concept can be made for parametric values of cabin pressure, crew size, cabin air dry and wet bulb temperatures, and mission duration.

Great Lakes/Saint Lawrence Seaway Regional Transportation Study for U.S. Army Corps of Engineers. Phase II. Summary Report.

DTIC Science & Technology

1982-03-01

electric utilities accounted for 68 percent of total coal use in the region and, excluding New York and Pennsylvania , accounted for 73 percent of total...center in Hamilton and the public utilities in Toronto. The vast majority of these shipments are loaded at U.S. Lake Erie ports. (2) The Great Lakes... Pennsylvania 37,249 23,281 192 3,870 64 New York 5,980 5,157 20 2,405 13 Total 189,784 60,889 2,360 26,753 279 Percent of Total 68 22 1 9 1 Total U.S. 454,861

Testing Genetic Pleiotropy with GWAS Summary Statistics for Marginal and Conditional Analyses.

PubMed

Deng, Yangqing; Pan, Wei

2017-12-01

There is growing interest in testing genetic pleiotropy, which is when a single genetic variant influences multiple traits. Several methods have been proposed; however, these methods have some limitations. First, all the proposed methods are based on the use of individual-level genotype and phenotype data; in contrast, for logistical, and other, reasons, summary statistics of univariate SNP-trait associations are typically only available based on meta- or mega-analyzed large genome-wide association study (GWAS) data. Second, existing tests are based on marginal pleiotropy, which cannot distinguish between direct and indirect associations of a single genetic variant with multiple traits due to correlations among the traits. Hence, it is useful to consider conditional analysis, in which a subset of traits is adjusted for another subset of traits. For example, in spite of substantial lowering of low-density lipoprotein cholesterol (LDL) with statin therapy, some patients still maintain high residual cardiovascular risk, and, for these patients, it might be helpful to reduce their triglyceride (TG) level. For this purpose, in order to identify new therapeutic targets, it would be useful to identify genetic variants with pleiotropic effects on LDL and TG after adjusting the latter for LDL; otherwise, a pleiotropic effect of a genetic variant detected by a marginal model could simply be due to its association with LDL only, given the well-known correlation between the two types of lipids. Here, we develop a new pleiotropy testing procedure based only on GWAS summary statistics that can be applied for both marginal analysis and conditional analysis. Although the main technical development is based on published union-intersection testing methods, care is needed in specifying conditional models to avoid invalid statistical estimation and inference. In addition to the previously used likelihood ratio test, we also propose using generalized estimating equations under the working independence model for robust inference. We provide numerical examples based on both simulated and real data, including two large lipid GWAS summary association datasets based on ∼100,000 and ∼189,000 samples, respectively, to demonstrate the difference between marginal and conditional analyses, as well as the effectiveness of our new approach. Copyright © 2017 by the Genetics Society of America.

Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189

PubMed Central

Reiner, Anton; Heldt, Scott A.; Presley, Chaela S.; Guley, Natalie H.; Elberger, Andrea J.; Deng, Yunping; D’Surney, Lauren; Rogers, Joshua T.; Ferrell, Jessica; Bu, Wei; Del Mar, Nobel; Honig, Marcia G.; Gurley, Steven N.; Moore, Bob M.

2014-01-01

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50–60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (CB2), we evaluated the effectiveness of the novel CB2 receptor inverse agonist SMM-189 in altering microglial activation and mitigating deficits after mild TBI. In vitro analysis indicated that SMM-189 converted human microglia from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype. Studies in mice showed that daily administration of SMM-189 for two weeks beginning shortly after blast greatly reduced the motor, visual, and emotional deficits otherwise evident after 50–60 psi blasts, and prevented brain injury that may contribute to these deficits. Our results suggest that treatment with the CB2 inverse agonist SMM-189 after a mild TBI event can reduce its adverse consequences by beneficially modulating microglial activation. These findings recommend further evaluation of CB2 inverse agonists as a novel therapeutic approach for treating mild TBI. PMID:25561230

Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.

PubMed

Reiner, Anton; Heldt, Scott A; Presley, Chaela S; Guley, Natalie H; Elberger, Andrea J; Deng, Yunping; D'Surney, Lauren; Rogers, Joshua T; Ferrell, Jessica; Bu, Wei; Del Mar, Nobel; Honig, Marcia G; Gurley, Steven N; Moore, Bob M

2014-12-31

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50-60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (CB2), we evaluated the effectiveness of the novel CB2 receptor inverse agonist SMM-189 in altering microglial activation and mitigating deficits after mild TBI. In vitro analysis indicated that SMM-189 converted human microglia from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype. Studies in mice showed that daily administration of SMM-189 for two weeks beginning shortly after blast greatly reduced the motor, visual, and emotional deficits otherwise evident after 50-60 psi blasts, and prevented brain injury that may contribute to these deficits. Our results suggest that treatment with the CB2 inverse agonist SMM-189 after a mild TBI event can reduce its adverse consequences by beneficially modulating microglial activation. These findings recommend further evaluation of CB2 inverse agonists as a novel therapeutic approach for treating mild TBI.

27 CFR 19.189 - Identification of structures, areas, apparatus, and equipment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... structures, areas, apparatus, and equipment. 19.189 Section 19.189 Alcohol, Tobacco Products and Firearms... Construction, Equipment, and Security Requirements Other Plant Requirements § 19.189 Identification of structures, areas, apparatus, and equipment. (a) Buildings. The proprietor must mark each building at a...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-7 - Examinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Examinations. 189.35-7 Section 189.35-7 Shipping COAST... CERTIFICATION Weight Handling Gear § 189.35-7 Examinations. (a) Examination of weight handling gear will normally consist of a visual examination with access covers removed. Suitability of the equipment for the...

10 CFR 26.189 - Determination of fitness.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Determination of fitness. 26.189 Section 26.189 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.189 Determination of fitness. (a) A determination of fitness is the process entered...

10 CFR 26.189 - Determination of fitness.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Determination of fitness. 26.189 Section 26.189 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.189 Determination of fitness. (a) A determination of fitness is the process entered...

Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope Cysteine Protease A Peptide-Based Nanovaccine

PubMed Central

Agallou, Maria; Margaroni, Maritsa; Athanasiou, Evita; Toubanaki, Dimitra K.; Kontonikola, Katerina; Karidi, Konstantina; Kammona, Olga; Kiparissides, Costas

2017-01-01

Background Through their increased potential to be engaged and processed by dendritic cells (DCs), nanovaccines consisting of Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with both antigenic moieties and adjuvants are attractive candidates for triggering specific defense mechanisms against intracellular pathogens. The aim of the present study was to evaluate the immunogenicity and prophylactic potential of a rationally designed multi-epitope peptide of Leishmania Cysteine Protease A (CPA160-189) co-encapsulated with Monophosphoryl lipid A (MPLA) in PLGA NPs against L. infantum in BALB/c mice and identify immune markers correlated with protective responses. Methodology/Principal Findings The DCs phenotypic and functional features exposed to soluble (CPA160-189, CPA160-189+MPLA) or encapsulated in PLGA NPs forms of peptide and adjuvant (PLGA-MPLA, PLGA-CPA160-189, PLGA-CPA160-189+MPLA) was firstly determined using BALB/c bone marrow-derived DCs. The most potent signatures of DCs maturation were obtained with the PLGA-CPA160-189+MPLA NPs. Subcutaneous administration of PLGA-CPA160-189+MPLA NPs in BALB/c mice induced specific anti-CPA160-189 cellular and humoral immune responses characterized by T cells producing high amounts of IL-2, IFN-γ and TNFα and IgG1/IgG2a antibodies. When these mice were challenged with 2x107 stationary phase L. infantum promastigotes, they displayed significant reduced hepatic (48%) and splenic (90%) parasite load at 1 month post-challenge. This protective phenotype was accompanied by a strong spleen lymphoproliferative response and high levels of IL-2, IFN-γ and TNFα versus low IL-4 and IL-10 secretion. Although, at 4 months post-challenge, the reduced parasite load was preserved in the liver (61%), an increase was detected in the spleen (30%), indicating a partial vaccine-induced protection. Conclusions/Significance This study provide a basis for the development of peptide-based nanovaccines against leishmaniasis, since it reveals that vaccination with well-defined Leishmania MHC-restricted epitopes extracted from various immunogenic proteins co-encapsulated with the proper adjuvant or/and phlebotomine fly saliva multi-epitope peptides into clinically compatible PLGA NPs could be a promising approach for the induction of a strong and sustainable protective immunity. PMID:28114333

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.35-1 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 189.35-1 Section 189.35-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Weight Handling Gear § 189.35-1 Application. (a) The requirements of this subpart shall apply to...

Generalized EC&LSS computer program configuration control

NASA Technical Reports Server (NTRS)

Blakely, R. L.

1976-01-01

The generalized environmental control and life support system (ECLSS) computer program (G189A) simulation of the shuttle orbiter ECLSS was upgraded. The G189A component model configuration was changed to represent the current PV102 and subsequent vehicle ECLSS configurations as defined by baseline ARS and ATCS schematics. The diagrammatic output schematics of the gas, water, and freon loops were also revised to agree with the new ECLSS configuration. The accuracy of the transient analysis was enhanced by incorporating the thermal mass effects of the equipment, structure, and fluid in the ARS gas and water loops and in the ATCS freon loops. The sources of the data used to upgrade the simulation are: (1) ATCS freon loop line sizes and lengths; (2) ARS water loop line sizes and lengths; (3) ARS water loop and ATCS freon loop component and equipment weights; and (4) ARS cabin and avionics bay thermal capacitance and conductance values. A single G189A combination master program library tape was generated which contains all of the master program library versions which were previously maintained on separate tapes. A new component subroutine, PIPETL, was developed and incorporated into the G189A master program library.

46 CFR 189.55-20 - Number of plans required.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Number of plans required. 189.55-20 Section 189.55-20... AND CERTIFICATION Plan Approval § 189.55-20 Number of plans required. (a) Three copies of each plan... additional approved plans, a suitable number should be submitted to permit the required distribution. [CGFR...

46 CFR 189.55-20 - Number of plans required.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Number of plans required. 189.55-20 Section 189.55-20... AND CERTIFICATION Plan Approval § 189.55-20 Number of plans required. (a) Three copies of each plan... additional approved plans, a suitable number should be submitted to permit the required distribution. [CGFR...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-25 - Hull equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Hull equipment. 189.25-25 Section 189.25-25 Shipping... CERTIFICATION Inspection for Certification § 189.25-25 Hull equipment. (a) At each inspection for certification and periodic inspection the inspector shall conduct the following tests and inspections of hull...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.20-10 - Plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Plans. 189.20-10 Section 189.20-10 Shipping COAST GUARD... Initial Inspection § 189.20-10 Plans. (a) Before application for inspection is made, and before construction is started, the owner or builder shall have plans approved by the Commandant indicating the...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Monochloroacetic acid. 189.155 Section 189.155... Prohibited From Direct Addition or Use as Human Food § 189.155 Monochloroacetic acid. (a) Monochloroacetic acid is the chemical chloroacetic acid, C2H3C1O2. It is a synthetic chemical not found in natural...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Certificates § 21.189 Issue of airworthiness certificate for limited category aircraft. (a) An applicant for an...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Certificates § 21.189 Issue of airworthiness certificate for limited category aircraft. (a) An applicant for an...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Certificates § 21.189 Issue of airworthiness certificate for limited category aircraft. (a) An applicant for an...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Addition to Human Food Through Food-Contact Surfaces § 189.220 Flectol H. (a) Flectol H is the chemical 1,2...

Generalized environmental control and life support system computer program (G189A) configuration control, phase 2

NASA Technical Reports Server (NTRS)

Mcenulty, R. E.

1977-01-01

The G189A simulation of the Shuttle Orbiter ECLSS was upgraded. All simulation library versions and simulation models were converted from the EXEC2 to the EXEC8 computer system and a new program, G189PL, was added to the combination master program library. The program permits the post-plotting of up to 100 frames of plot data over any time interval of a G189 simulation run. The overlay structure of the G189A simulations were restructured for the purpose of conserving computer core requirements and minimizing run time requirements.

46 CFR 189.25-45 - Fire hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Fire hazards. 189.25-45 Section 189.25-45 Shipping COAST... CERTIFICATION Inspection for Certification § 189.25-45 Fire hazards. At each inspection for certification and... that there is no accumulation of oil which might create a fire hazard. [CGFR 67-83, 33 FR 1118, Jan. 27...

21 CFR 189.240 - Lead solders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Lead solders. 189.240 Section 189.240 Food and...-Contact Surfaces § 189.240 Lead solders. (a) Lead solders are alloys of metals that include lead and are used in the construction of metal food cans. (b) Food packaged in any container that makes use of lead...

21 CFR 189.240 - Lead solders.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Lead solders. 189.240 Section 189.240 Food and... Addition to Human Food Through Food-Contact Surfaces § 189.240 Lead solders. (a) Lead solders are alloys of metals that include lead and are used in the construction of metal food cans. (b) Food packaged in any...

21 CFR 189.240 - Lead solders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Lead solders. 189.240 Section 189.240 Food and... Addition to Human Food Through Food-Contact Surfaces § 189.240 Lead solders. (a) Lead solders are alloys of metals that include lead and are used in the construction of metal food cans. (b) Food packaged in any...

21 CFR 189.240 - Lead solders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Lead solders. 189.240 Section 189.240 Food and... Addition to Human Food Through Food-Contact Surfaces § 189.240 Lead solders. (a) Lead solders are alloys of metals that include lead and are used in the construction of metal food cans. (b) Food packaged in any...

21 CFR 189.240 - Lead solders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Lead solders. 189.240 Section 189.240 Food and... Addition to Human Food Through Food-Contact Surfaces § 189.240 Lead solders. (a) Lead solders are alloys of metals that include lead and are used in the construction of metal food cans. (b) Food packaged in any...

Twitter Social Media is an Effective Tool for Breast Cancer Patient Education and Support: Patient-Reported Outcomes by Survey.

PubMed

Attai, Deanna J; Cowher, Michael S; Al-Hamadani, Mohammed; Schoger, Jody M; Staley, Alicia C; Landercasper, Jeffrey

2015-07-30

Despite reported benefits, many women do not attend breast cancer support groups. Abundant online resources for support exist, but information regarding the effectiveness of participation is lacking. We report the results of a Twitter breast cancer support community participant survey. The aim was to determine the effectiveness of social media as a tool for breast cancer patient education and decreasing anxiety. The Breast Cancer Social Media Twitter support community (#BCSM) began in July 2011. Institutional review board approval with a waiver of informed consent was obtained for a deidentified survey that was posted for 2 weeks on Twitter and on the #BCSM blog and Facebook page. There were 206 respondents to the survey. In all, 92.7% (191/206) were female. Respondents reported increased knowledge about breast cancer in the following domains: overall knowledge (80.9%, 153/189), survivorship (85.7%, 162/189), metastatic breast cancer (79.4%, 150/189), cancer types and biology (70.9%, 134/189), clinical trials and research (66.1%, 125/189), treatment options (55.6%, 105/189), breast imaging (56.6%, 107/189), genetic testing and risk assessment (53.9%, 102/189), and radiotherapy (43.4%, 82/189). Participation led 31.2% (59/189) to seek a second opinion or bring additional information to the attention of their treatment team and 71.9% (136/189) reported plans to increase their outreach and advocacy efforts as a result of participation. Levels of reported anxiety before and after participation were analyzed: 29 of 43 (67%) patients who initially reported "high or extreme" anxiety reported "low or no" anxiety after participation (P<.001). Also, no patients initially reporting low or no anxiety before participation reported an increase to high or extreme anxiety after participation. This study demonstrates that breast cancer patients' perceived knowledge increases and their anxiety decreases by participation in a Twitter social media support group.

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

150 {mu}A 18F{sup -} target and beam port upgrade for the IBA 18/9 cyclotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stokely, M. H.; Peeples, J. L.; Poorman, M. C.

2012-12-19

A high power ({approx}3 kW) target platform has been developed for the IBA 18/9 cyclotron. New designs for the airlock, collimator and target subsystems have been fabricated and deployed. The primary project goal is reliable commercial production of 18F{sup -} at 150 {mu}A or greater, while secondary goals include improving serviceability and extending service intervals relative to OEM systems. Reliable operation in a production environment has been observed at beam currents up to 140 {mu}A. Challenges include ion source lifetime and localized peaking in the beam intensity distribution.

46 CFR 189.60-1 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 189.60-1 Section 189.60-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-1 Application...

49 CFR 37.189 - Service requirement for OTRB demand-responsive systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Service requirement for OTRB demand-responsive systems. 37.189 Section 37.189 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.189 Service requirement...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

Development of km23-Based Diagnostics and Therapeutics

DTIC Science & Technology

2005-05-01

A107km23), instead of the wild-type 96-amino acid form of km23. Furthermore, five missense mutations (T381, S55G, T56S, 189V, and V90A) were detected in...acid form of 1um23. Furthermore, five TPR-I, and T41R-II can lead to disruption of TGF-P3-signaling missense mutations (T381, S55G, T56S, 189V, and V9OA...these alterations, the three other missense mutations detected (CKII) in km23. For these sites, the prediction scores for serine and in three other

46 CFR 189.20-20 - Specific tests and inspections.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Specific tests and inspections. 189.20-20 Section 189.20-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-20 Specific tests and inspections. The applicable tests and inspections as set forth in...

46 CFR 189.20-20 - Specific tests and inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Specific tests and inspections. 189.20-20 Section 189.20-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-20 Specific tests and inspections. The applicable tests and inspections as set forth in...

15 CFR 18.9 - Awards against other agencies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Awards against other agencies. 18.9 Section 18.9 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES General Provisions § 18.9 Awards against other agencies. If an applicant is entitled to an award...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General Provisions § 189.1 Substances prohibited...

Design and installation of a subsea multiwell drilling template at Garden Banks Block 189

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domangue, R.J.

1991-09-01

This paper describes the economics, design, and installation of a simple drilling template that was used to retain or save subsea exploratory and delineation wells in Garden Banks Block 189 (GB 189) in the Gulf of Mexico.

Airway clearance techniques in acute exacerbations of COPD: a survey of Australian physiotherapy practice.

PubMed

Osadnik, Christian R; McDonald, Christine F; Holland, Anne E

2013-06-01

To identify airway clearance techniques (ACTs) used to treat patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and identify factors underpinning their utilisation, including therapists' knowledge of the literature. Cross-sectional postal survey using Likert scales and multiple-choice responses. 112 'large' or 'principal referral' Australian public hospitals. 189 physiotherapists from 89 hospitals (response rate 81%). Purpose designed survey measuring self-reported rate of ACT prescription; perception of ACT indications, aims, importance and effectiveness; factors influencing ACT choice; and knowledge of the evidence. Most physiotherapists (123/189, 65%) prescribed ACTs for 60-100% of patients with AECOPDs. The most frequently prescribed ACTs were physical exercise (169/189, 89%), the forced expiratory technique (153/189, 81%) and the active cycle of breathing technique (149/189, 79%). Most were rated highly effective. Physiotherapists who perceived the role of ACTs to be important to patients' overall management (137/189, 73%) and those with less than 5 years cardiorespiratory experience (113/189, 60%) prescribed ACTs significantly more frequently than others. The main factors influencing ACT choice were precautions/contraindications to individual techniques (148/189, 78%) and degree of dyspnoea (136/189, 72%). The primary aim of ACT prescription was to clear sputum (178/189, 94%). Understanding of the evidence for ACTs in AECOPDs was mixed, with 43% citing it as supportive, 30% inconclusive and 19% unsure. Australian physiotherapists frequently prescribe ACTs for patients with AECOPDs and perceive their role to be important. Physical exercise is frequently prescribed for airway clearance and warrants further investigation. Copyright © 2012 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Flight instructor records. 61.189 Section...) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors Other than Flight Instructors With a Sport Pilot Rating § 61.189 Flight instructor records. (a) A flight instructor...

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Flight instructor records. 61.189 Section...) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors Other than Flight Instructors With a Sport Pilot Rating § 61.189 Flight instructor records. (a) A flight instructor...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10 Section 189.60-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-10 Cargo Ship Safety...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5 Section 189.60-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-5 Cargo Ship Safety...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section 189.60-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-15 Cargo Ship Safety Radio...

Inactivation of DNA-Binding Response Regulator Sak189 Abrogates β-Antigen Expression and Affects Virulence of Streptococcus agalactiae

PubMed Central

Rozhdestvenskaya, Anastasia S.; Totolian, Artem A.; Dmitriev, Alexander V.

2010-01-01

Background Streptococcus agalactiae is able to colonize numerous tissues employing different mechanisms of gene regulation, particularly via two-component regulatory systems. These systems sense the environmental stimuli and regulate expression of the genes including virulence genes. Recently, the novel two-component regulatory system Sak188/Sak189 was identified. In S. agalactiae genome, it was adjacent to the bac gene encoding for β-antigen, an important virulence factor. Methodology/Principal Findings In this study, the sak188 and sak189 genes were inactivated, and the functional role of Sak188/Sak189 two-component system in regulation of the β-antigen expression was investigated. It was demonstrated that both transcription of bac gene and expression of encoded β-antigen were controlled by Sak189 response regulator, but not Sak188 histidine kinase. It was also found that the regulation occurred at transcriptional level. Finally, insertional inactivation of sak189 gene, but not sak188 gene, significantly affected virulent properties of S. agalactiae. Conclusions/Significance Sak189 response regulator is necessary for activation of bac gene transcription. It also controls the virulent properties of S. agalactiae. Given that the primary functional role of Sak188/Sak189 two-component systems is a control of bac gene transcription, this system can be annotated as BgrR/S (bac gene regulatory system). PMID:20419089

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Flight instructor records. 61.189 Section 61.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... person that instructor has endorsed for a knowledge test or practical test, and the record shall also...

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight instructor records. 61.189 Section 61.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... person that instructor has endorsed for a knowledge test or practical test, and the record shall also...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... a condition for safe operation. (b) The Administrator prescribes limitations and conditions...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... a condition for safe operation. (b) The Administrator prescribes limitations and conditions...

Crew appliance computer program manual, volume 1

NASA Technical Reports Server (NTRS)

Russell, D. J.

1975-01-01

Trade studies of numerous appliance concepts for advanced spacecraft galley, personal hygiene, housekeeping, and other areas were made to determine which best satisfy the space shuttle orbiter and modular space station mission requirements. Analytical models of selected appliance concepts not currently included in the G-189A Generalized Environmental/Thermal Control and Life Support Systems (ETCLSS) Computer Program subroutine library were developed. The new appliance subroutines are given along with complete analytical model descriptions, solution methods, user's input instructions, and validation run results. The appliance components modeled were integrated with G-189A ETCLSS models for shuttle orbiter and modular space station, and results from computer runs of these systems are presented.

Generalized environmental control and life support system computer program (G189A) configuration control. [computer subroutine libraries for shuttle orbiter analyses

NASA Technical Reports Server (NTRS)

Blakely, R. L.

1973-01-01

A G189A simulation of the shuttle orbiter EC/lSS was prepared and used to study payload support capabilities. Two master program libraries of the G189A computer program were prepared for the NASA/JSC computer system. Several new component subroutines were added to the G189A program library and many existing subroutines were revised to improve their capabilities. A number of special analyses were performed in support of a NASA/JSC shuttle orbiter EC/LSS payload support capability study.

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Skim milk cheese for manufacturing. 133.189... (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.189 Skim milk cheese for manufacturing. (a) Skim milk cheese for...

14 CFR 125.189 - Demonstration of emergency evacuation procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the emergency evacuation procedures for each type and model of airplane with a seating of more than 44... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Demonstration of emergency evacuation procedures. 125.189 Section 125.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

38 CFR 18.9 - Hearings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Hearings. 18.9 Section 18... THE CIVIL RIGHTS ACT OF 1964 General § 18.9 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing is required by § 18.8(c), reasonable notice shall be given by registered or...

38 CFR 18.9 - Hearings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Hearings. 18.9 Section 18... THE CIVIL RIGHTS ACT OF 1964 General § 18.9 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing is required by § 18.8(c), reasonable notice shall be given by registered or...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

Screening Mammography and Digital Breast Tomosynthesis: Utilization Updates.

PubMed

Boroumand, Gilda; Teberian, Ida; Parker, Laurence; Rao, Vijay M; Levin, David C

2018-05-01

There have been many recent developments in breast imaging, including the 2009 revision of the U.S. Preventive Services Task Force's breast cancer screening guidelines and the approval of digital breast tomosynthesis (DBT) for clinical use in 2011. The objective of this study is to evaluate screening mammography utilization trends among the Medicare population from 2005 to 2015 and examine the volume of DBT studies performed in 2015, the first year for which procedural billing codes for DBT are available. We reviewed national Medicare Part B Physician/Supplier Procedure Summary master files from 2005 to 2015, to determine the annual utilization rate of screening mammography on the basis of procedure codes used for film-screen and digital screening mammography. We also used the Physician/Supplier Procedure Summary master files to determine the volume of screening and diagnostic DBT studies performed in 2015. The utilization rate of screening mammography per 1000 women in the Medicare fee-for-service population increased gradually every year, from 311.5 examinations in 2005 to a peak of 322.9 examinations in 2009, representing a compound annual growth rate of 0.9%. In 2010, the utilization rate abruptly decreased by 4.3% to 309.2 examinations, and it has not since recovered to pre-2010 levels. In 2015, 18.9% of screening and 16.2% of diagnostic digital mammography examinations included DBT as an add-on procedure. In contrast to the annual increase in screening mammography utilization from 2005 to 2009, an abrupt sustained decline in screening occurred beginning in 2010, coinciding with the release of U.S. Preventive Services Task Force recommendations. DBT utilization was somewhat limited in 2015, occurring in conjunction with less than 20% of digital mammography examinations.

40 CFR 93.101 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

...(c)(2)(A), 182(c)(2)(B), 187(a)(7), 187(g), 189(a)(1)(B), 189(b)(1)(A), and 189(d); sections 192(a... project, e.g., freeway, expressway, arterial highway, grade-separated highway, reserved right-of-way rail... person carrying capacity and control, e.g., number of lanes or tracks to be constructed or added, length...

40 CFR 93.101 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

...), 182(c)(2)(B), 187(a)(7), 187(g), 189(a)(1)(B), 189(b)(1)(A), and 189(d); sections 192(a) and 192(b... further progress or attainment). Design concept means the type of facility identified by the project, e.g... capacity and control, e.g., number of lanes or tracks to be constructed or added, length of project...

40 CFR 93.101 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

...), 182(c)(2)(B), 187(a)(7), 187(g), 189(a)(1)(B), 189(b)(1)(A), and 189(d); sections 192(a) and 192(b... further progress or attainment). Design concept means the type of facility identified by the project, e.g... capacity and control, e.g., number of lanes or tracks to be constructed or added, length of project...

Photosynthetic water oxidation in Synechocystis sp. PCC6803: mutations D1-E189K, R and Q are without influence on electron transfer at the donor side of photosystem II.

PubMed

Clausen, J; Winkler, S; Hays, A M; Hundelt, M; Debus, R J; Junge, W

2001-11-01

The oxygen-evolving manganese cluster (OEC) of photosynthesis is oxidised by the photochemically generated primary oxidant (P(+*)(680)) of photosystem II via a tyrosine residue (Y(Z), Tyr161 on the D1 subunit of Synechocystis sp. PCC6803). The redox span between these components is rather small and probably tuned by protonic equilibria. The very efficient electron transfer from Y(Z) to P(+*)(680) in nanoseconds requires the intactness of a hydrogen bonded network involving Y(Z), D1-His190, and presumably D1-Glu189. We studied photosystem II core particles from photoautotrophic mutants where the residue D1-E189 was replaced by glutamine, arginine and lysine which were expected to electrostatically differ from the glutamate in the wild-type (WT). Surprisingly, the rates of electron transfer from Y(Z) to P(+*)(680) as well as from the OEC to Y(ox)(Z) were the same as in the WT. With the generally assumed proximity between D1-His190 (and thus D1-Glu189) and Y(Z), the lack of any influence on the electron transfer around Y(Z) straightforwardly implies a strongly hydrophobic environment forcing Glu (acid) and Lys, Arg (basic) at position D1-189 into electro-neutrality. As one alternative, D1-Glu189 could be located at such a large distance from the OEC, Y(Z) and P(+*)(680) that a charge on D1-189X does not influence the electron transfer. This seems less likely in the light of the drastic influence of its direct neighbour, D1-His190, on Y(Z) function. Another alternative is that D1-Glu189 is negatively charged, but is located in a cluster of acid/base groups that compensates for an alteration of charge at position 189, leaving the overall net charge unchanged in the Gln, Lys, and Arg mutants.

United States Air Force Summary, Amended FY 1990/1991 Biennial Budget. Fifteenth Edition

DTIC Science & Technology

1989-12-15

v~t YEAR ...... Oaf Ml; JCI edl.l Ben/ 1960 48. 1 11 6 1.7 12.8 6.9 11.0 92.2 19t)1 49,6 4~;p ɡ.0.[. J$.4 •••<J~1~t••.• 1962 52.3 14.4 2.4 14.8...195 178 189 200 218 218 AFLEGAL SVCSCTR 513 ...... . . <.59t.525 .Ji43 566 � <~ 598 Officers 244 247 259 274 287 299 303 304 Enlisted 131 126 138 144...67 63 62 59 60 177 194 129 AF OFF SEC POUCE -: 72 113 123 ...135 131 127 t34 128 Officers 35 36 38 43 40 35 34 34 Enlisted 14 20 26 31 32 30 37 34

21 CFR 189.120 - Cobaltous salts and its derivatives.

Code of Federal Regulations, 2010 CFR

2010-04-01

... malt beverages as a foam stabilizer and to prevent “gushing.” (b) Food containing any added cobaltous... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cobaltous salts and its derivatives. 189.120 Section 189.120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2011 CFR

2011-04-01

... products, and has been used as a component of food packaging adhesives. (b) Food containing any added or... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2014 CFR

2014-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2011 CFR

2011-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2013 CFR

2013-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2012 CFR

2012-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2012 CFR

2012-04-01

... products, and has been used as a component of food packaging adhesives. (b) Food containing any added or... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2013 CFR

2013-04-01

... products, and has been used as a component of food packaging adhesives. (b) Food containing any added or... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.120 - Cobaltous salts and its derivatives.

Code of Federal Regulations, 2011 CFR

2011-04-01

... malt beverages as a foam stabilizer and to prevent “gushing.” (b) Food containing any added cobaltous... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Cobaltous salts and its derivatives. 189.120 Section 189.120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

Dynamic changes in the date palm fruit proteome during development and ripening

PubMed Central

Marondedze, Claudius; Gehring, Christoph; Thomas, Ludivine

2014-01-01

Date palm (Phoenix dactylifera) is an economically important fruit tree in the Middle East and North Africa and is characterized by large cultivar diversity, making it a good model for studies on fruit development and other important traits. Here in gel comparative proteomics combined with tandem mass spectrometry were used to study date fruit development and ripening. Total proteins were extracted using a phenol-based protocol. A total of 189 protein spots were differentially regulated (p≤0.05). The identified proteins were classified into 14 functional categories. The categories with the most proteins were ‘disease and defense’ (16.5%) and ‘metabolism’ (15.4%). Twenty-nine proteins have not previously been identified in other fleshy fruits and 64 showed contrasting expression patterns in other fruits. Abundance of most proteins with a role in abiotic stress responses increased during ripening with the exception of heat shock proteins. Proteins with a role in anthocyanin biosynthesis, glycolysis, tricarboxylic acid cycle and cell wall degradation were upregulated particularly from the onset of ripening and during ripening. In contrast, expression of pentose phosphate- and photosynthesis-related proteins decreased during fruit maturation. Although date palm is considered a climacteric species, the analysis revealed downregulation of two enzymes involved in ethylene biosynthesis, suggesting an ethylene-independent ripening of ‘Barhi’ fruits. In summary, this proteomics study provides insights into physiological processes during date fruit development and ripening at the systems level and offers a reference proteome for the study of regulatory mechanisms that can inform molecular and biotechnological approaches to further improvements of horticultural traits including fruit quality and yield. PMID:26504545

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2014 CFR

2014-04-01

... natural products and has been used as a polyurethane curing agent and as a component of food packaging... 21 Food and Drugs 3 2014-04-01 2014-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

Dimensions of the epilepsy foundation concerns index.

PubMed

Loring, David W; Larrabee, Glenn J; Meador, Kimford J; Lee, Gregory P

2005-05-01

We performed principal component analysis (PCA) of the Epilepsy Foundation Concerns Index scale in 189 patients undergoing evaluation for epilepsy surgery. We identified a five-factor solution in which there were no varimax-rotated factors consisting of fewer than two questions. Factor 1 reflects affective impact on enjoyment of life, Factor 2 reflects general autonomy concerns, Factor 3 reflects fear of seizure recurrence, Factor 4 reflects concern of being a burden to one's family, and Factor 5 reflects a perceived lack of understanding by others. Multiple regression using the Quality of Life in Epilepsy--89 question version; Minnesota Multiphasic Personality Inventory--2; Wechsler Adult Intelligence Scale--third edition; and verbal and visual memory tests as predictors demonstrated a different pattern of association with the factor and summary scores. We conclude that the Epilepsy Foundation Concerns Index is multidimensional, and using a global score based on all items may mask specific concerns that may be relevant when applied to individual patients.

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... (d) For the purposes of this section, “skim milk” means cow's milk from which the milk fat has been... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Skim milk cheese for manufacturing. 133.189... Standardized Cheese and Related Products § 133.189 Skim milk cheese for manufacturing. (a) Skim milk cheese for...

21 CFR 189.301 - Tin-coated lead foil capsules for wine bottles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Tin-coated lead foil capsules for wine bottles. 189... Substances Prohibited From Indirect Addition to Human Food Through Food-Contact Surfaces § 189.301 Tin-coated lead foil capsules for wine bottles. (a) Tin-coated lead foil is composed of a lead foil coated on one...

Verification of a national water data base using a geographic information system

USGS Publications Warehouse

Harrison, H.E.

1994-01-01

The National Water Data Exchange (NAWDEX) was developed to assist users of water-resource data in the identification, location, and acquisition of data. The Master Water Data Index (MWDI) of NAWDEX currently indexes the data collected by 423 organizations from nearly 500,000 sites throughout the United Stales. The utilization of new computer technologies permit the distribution of the MWDI to the public on compact disc. In addition, geographic information systems (GIS) are now available that can store and analyze these data in a spatial format. These recent innovations could increase access and add new capabilities to the MWDI. Before either of these technologies could be employed, however, a quality-assurance check of the MWDI needed to be performed. The MWDI resides on a mainframe computer in a tabular format. It was copied onto a workstation and converted to a GIS format. The GIS was used to identify errors in the MWDI and produce reports that summarized these errors. The summary reports were sent to the responsible contributing agencies along with instructions for submitting their corrections to the NAWDEX Program Office. The MWDI administrator received reports that summarized all of the errors identified. Of the 494,997 sites checked, 93,440 sites had at least one error (18.9 percent error rate).

7 CFR 4288.138-4288.189 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false [Reserved] 4288.138-4288.189 Section 4288.138-4288.189 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

7 CFR 4288.138-4288.189 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false [Reserved] 4288.138-4288.189 Section 4288.138-4288.189 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

7 CFR 4288.138-4288.189 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false [Reserved] 4288.138-4288.189 Section 4288.138-4288.189 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Master's responsibility. 189.35-13 Section 189.35-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION... appropriate showing such items as inspections, tests, important repairs and casualties experienced. This...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

Annual summary of ground-water conditions in Arizona, Spring 1981 to Spring 1982

USGS Publications Warehouse

,

1982-01-01

The withdrawal of ground water was about 5.4 million acre-feet in Arizona in 1981, which is about 800,000 acre-feet more than the amount withdrawn in 1980. Most of the increase in 1981 was in the amount of ground water used for irrigation in the Basin and Range lowlands province. Through 1981, slightly more than 189 million acre-feet of ground water had been withdrawn from the ground-water reservoirs in Arizona. The report contains two small-scale maps that show ground-water pumpage by areas and the status of the ground-water inventory in the State. The main map, which is at a scale of 1:500,000, shows potential well production, depth to water in selected wells in spring 1982, and change in water level in selected wells from 1977 to 1982. A brief text summarizes the current ground-water conditions in the State. (USGS)

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Safrole. 189.180 Section 189.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.113 - Cinnamyl anthranilate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cinnamyl anthranilate. 189.113 Section 189.113 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189.165 Nordihydroguaiaretic acid (NDGA...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.250 - Mercaptoimidazoline and 2-mercaptoimidazoline.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Mercaptoimidazoline and 2-mercaptoimidazoline. 189.250 Section 189.250 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

30 CFR 18.9 - Conduct of investigations and tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Conduct of investigations and tests. 18.9 Section 18.9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES General...

46 CFR 189.45-5 - Inspection required.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Inspection required. 189.45-5 Section 189.45-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... partial depending upon the circumstances, shall be made whenever any important repairs or alterations are...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES General Information and Correspondence in...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.140 - Diethylpyrocarbonate (DEPC).

Code of Federal Regulations, 2010 CFR

2010-04-01

... alcoholic and nonalcoholic beverages. (b) Food containing any added or detectable level of DEPC is deemed to... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Diethylpyrocarbonate (DEPC). 189.140 Section 189.140 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 2 2011-04-01 2011-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 2 2012-04-01 2012-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

46 CFR 189.40-1 - Definitions relating to hull examinations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Definitions relating to hull examinations. 189.40-1 Section 189.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... fuel oil tanks. (c) Underwater survey means the examination, while the vessel is afloat, of all...

46 CFR 189.40-1 - Definitions relating to hull examinations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Definitions relating to hull examinations. 189.40-1 Section 189.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... fuel oil tanks. (c) Underwater survey means the examination, while the vessel is afloat, of all...

46 CFR 189.40-1 - Definitions relating to hull examinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Definitions relating to hull examinations. 189.40-1 Section 189.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... fuel oil tanks. (c) Underwater survey means the examination, while the vessel is afloat, of all...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2014 CFR

2014-04-01

... component of food packaging adhesives. (b) Food containing any added or detectable level of this substance... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

34 CFR 668.189 - General requirements for adjusting official cohort default rates and for appealing their...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false General requirements for adjusting official cohort default rates and for appealing their consequences. 668.189 Section 668.189 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF...

18 CFR 367.1890 - Account 189, Unamortized loss on reacquired debt.

Code of Federal Regulations, 2010 CFR

2010-04-01

... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Deferred Debits § 367.1890 Account 189... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account 189, Unamortized loss on reacquired debt. 367.1890 Section 367.1890 Conservation of Power and Water Resources...

25 CFR 900.189 - Does this coverage extend to subcontractors of self-determination contracts?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Does this coverage extend to subcontractors of self-determination contracts? 900.189 Section 900.189 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... this coverage extend to subcontractors of self-determination contracts? No. Subcontractors or...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2012 CFR

2012-04-01

... detecting coumarin in food are in sections 19.016-19.024 of the “Official Methods of Analysis of the... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2014 CFR

2014-04-01

... method used for detecting NDGA in food is in section 20.008(b) of the “Official Methods of Analysis of... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2014 CFR

2014-04-01

... monochloroacetic acid in food are in sections 20.067-20.072 of the “Official Methods of Analysis of the Association... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2013 CFR

2013-04-01

... detecting coumarin in food are in sections 19.016-19.024 of the “Official Methods of Analysis of the... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... detecting coumarin in food are in sections 19.016-19.024 of the “Official Methods of Analysis of the... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

IGF-I Polymorphism is Associated with Lean Mass, Exercise Economy and Performance Among Premenopausal Women

PubMed Central

López-Alarcón, Mardya; Hunter, Gary R.; Gower, Barba A.; Fernández, José R.

2007-01-01

Background We undertook this study to investigate the association of a genetic polymorphism of the insulin-like growth factor, IGF-I189, on body composition, exercise performance and exercise economy, after controlling for the independent effect of race as assessed by African genetic admixture (AFADM). Methods A total of 114 premenopausal sedentary women were genotyped for IGF-I189, obtaining measures of fat mass, lean body mass, VO2 during cycling and stairclimbing, time on treadmill and leg strength. A quantitative value for AFADM was derived from genotypic information of approximately 40 ancestry informative markers and used as covariate in statistical models. Results After adjusting for AFADM, IGF-I189 was negatively associated with lean body mass (p = 0.029) and lean leg mass (p = 0.050). Leg strength was not associated with the presence/absence of IGF-I189 (p = 0.380), but carriers of the allele demonstrated a longer time on the treadmill (p = 0.015) after adjusting for AFADM. There was also a negative relationship between oxygen uptake during cycling and presence of the IGF-I189 independent of AFADM (p = 0.010). Conclusion Independent of AFADM, individuals with IGF-I189 are more likely to have low leg lean mass and to perform better in activities requiring exercise economy and endurance performance. PMID:17174724

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2014 CFR

2014-04-01

... manufacture of rigid vinyl chloride polymer bottles. (b) Food containing any added or detectable levels of... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2011 CFR

2011-04-01

... component of food packaging adhesives and polyurethane resins. (b) Food containing any added or detectable... 21 Food and Drugs 3 2011-04-01 2011-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2013 CFR

2013-04-01

... component of food packaging adhesives and polyurethane resins. (b) Food containing any added or detectable... 21 Food and Drugs 3 2013-04-01 2013-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2012 CFR

2012-04-01

... component of food packaging adhesives and polyurethane resins. (b) Food containing any added or detectable... 21 Food and Drugs 3 2012-04-01 2012-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM...

The ability of an arginine to tryptophan substitution in Saccharomyces cerevisiae tRNA nucleotidyltransferase to alleviate a temperature-sensitive phenotype suggests a role for motif C in active site organization.

PubMed

Goring, Mark E; Leibovitch, Matthew; Gea-Mallorqui, Ester; Karls, Shawn; Richard, Francis; Hanic-Joyce, Pamela J; Joyce, Paul B M

2013-10-01

We report that the temperature-sensitive (ts) phenotype in Saccharomyces cerevisiae associated with a variant tRNA nucleotidyltransferase containing an amino acid substitution at position 189 results from a reduced ability to incorporate AMP and CMP into tRNAs. We show that this defect can be compensated for by a second-site suppressor converting residue arginine 64 to tryptophan. The R64W substitution does not alter the structure or thermal stability of the enzyme dramatically but restores catalytic activity in vitro and suppresses the ts phenotype in vivo. R64 is found in motif A known to be involved in catalysis and nucleotide triphosphate binding while E189 lies within motif C previously thought only to connect the head and neck domains of the protein. Although mutagenesis experiments indicate that residues R64 and E189 do not interact directly, our data suggest a critical role for residue E189 in enzyme structure and function. Both R64 and E189 may contribute to the organization of the catalytic domain of the enzyme. These results, along with overexpression and deletion analyses, show that the ts phenotype of cca1-E189F does not arise from thermal instability of the variant tRNA nucleotidyltransferase but instead from the inability of a partially active enzyme to support growth only at higher temperatures. © 2013.

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2012 CFR

2012-04-01

... resins are used in the manufacture of rigid vinyl chloride polymer bottles. (b) Food containing any added... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2013 CFR

2013-04-01

... resins are used in the manufacture of rigid vinyl chloride polymer bottles. (b) Food containing any added... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

Funding Public Higher Education in Colorado: How Has the College Opportunity Funding Model Impacted Educational Funding and Performance?

ERIC Educational Resources Information Center

Middlemist, George Edward

2017-01-01

During the 2004 legislative session, the Colorado General Assembly enacted Senate Bill 189 (SB189), which established the first system of college vouchers in the United States. The supporters of SB189 hoped that the voucher system, called the College Opportunity Fund (COF), would: 1) stabilize the flow of state funding to higher education; 2)…

Corporations now included under Section 189

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arlinghaus, B.P.; Anderson, D.T.

1983-12-01

This article examines some of the issues, including the ''real property'' question, that corporations may encounter in implementing the provisions of Code Section 189 and its regulations. The extension of 189 to regular corporations represents a significant change in congressional intent, since it was originally enacted as a reform measure and is now primarily a provision to raise revenue at a time when Congress is facing a large dificit. Code Section 189 was conceived and enacted in haste, however, and this expansion will undoubtedly have an adverse impact on capital investment at a time when stimulation is needed for themore » economy as a whole. The workload of the courts and the Internal Revenue Service will certainly increase. Careful drafting of the regulations could anticipate potential issues and clarify them in the drafting stage. The meaning of real property, capitalization rate, capitalization period, and self-constructed assets all need to be carefully addressed. 18 references.« less

An Interactive Psychoeducational Intervention for Women at Risk of Developing an Eating Disorder

ERIC Educational Resources Information Center

Zabinski, Marion F.; Wilfley, Denise E.; Calfas, Karen J.; Winzelberg, Andrew J.; Taylor, C. Barr

2004-01-01

This study evaluated a synchronous Internet-delivered intervention (chat room) for improving eating habits and body image in college-age women at risk for developing an eating disorder. Sixty at-risk women (mean age = 18.9, SD = 2.4; 65.0% Caucasian, 19% Latino/Hispanic, 8% Asian/Pacific Islander, 3% African American, 5% other; mean body mass…

Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk

PubMed Central

Rohmah, Rista Nikmatu; Hardiyanti, Ferlany; Fatchiyah, Fatchiyah

2015-01-01

Background: RA is a systemic inflammatory disease that causes developing comorbidity conditions. This condition can cause by overproduction of pro-inflammatory cytokine. In a previous study, we have found bioactive peptide CSN1S2 from Ethawah goat milk for anti-inflammatory for repair the ileum destruction. However, the signaling transduction cascade of bioactive peptides inhibits inflammation still not clear yet. Therefore, we analyzed the signaling transduction cascade via JAK-STAT3 pathway by in vivo and in silico. Methods: The ileum was isolated DNA and amplification with specific primer. The sequence was analyzed using the Sanger sequencing method. Modeling 3D-structure was predicted by SWISS-MODEL and virtual interaction was analyzed by docking system using Pymol and Discovery Studio 4.0 software. Results: This study showed that STAT3 has target gene 480bp. The normal group and normal treating- CSN1S2 of goat milk have similarity from gene bank. Whereas, RA group had transversion mutation that the purine change into pyrimidine even cause frameshift mutation. Interestingly, after treating with the CSN1S2 protein of goat milk shows reverse to the normal acid sequence group. Based on in silico study, from eight peptides, only three peptides of CSN1S2 protein, which carried by PePT1 to enter the small intestine. The fragments are PepT1-41-NMAIHPR-47; PepT1-182-KISQYYQK-189 and PepT1-214-TNAIPYVR-221. We have found just one bioactive peptide of f182-KISQYYQK-189 is able bind to STAT3. The energy binding of f182-KISQYYQK-189 and RA-STAT3 amino acid, it was Σ = -402.43 kJ/mol and the energy binding of f182-KISQYYQK-189 and RAS-STAT3 amino acid is decreasing into Σ = -407.09 kJ/mol. Conclusion: This study suggested that the fragment 182-KISQYYQK-189 peptides from Ethawah goat milk may act as an anti-inflammatory agent via JAK-STAT3 signal transduction cascade at the cellular level. PMID:26483598

Roadmapping towards Sustainability Proficiency in Engineering Education

ERIC Educational Resources Information Center

Rodriguez-Andara, Alejandro; Río-Belver, Rosa María; Rodríguez-Salvador, Marisela; Lezama-Nicolás, René

2018-01-01

Purpose: The purpose of this paper is to deliver a roadmap that displays pathways to develop sustainability skills in the engineering curricula. Design/methodology/approach: The selected approach to enrich engineering students with sustainability skills was active learning methodologies. First, a survey was carried out on a sample of 189 students…

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

A Comparison of Radical Perineal, Radical Retropubic, and Robot-Assisted Laparoscopic Prostatectomies in a Single Surgeon Series

PubMed Central

Mirza, Moben; Art, Kevin; Wineland, Logan; Tawfik, Ossama; Thrasher, J. Brantley

2011-01-01

Objective. We sought to compare positive surgical margin rates (PSM), estimated blood loss (EBL), and quality of life outcomes (QOL) among perineal (RPP), retropubic (RRP), and robot-assisted laparoscopic (RALP) prostatectomies. Methods. Records from 463 consecutive men undergoing RPP (92), RRP (180), or RALP (191) for clinically localized prostate cancer were retrospectively reviewed. Age, percent tumor volume, Gleason score, stage, EBL, PSM, and QOL using the expanded prostate cancer index composite (EPIC) were compared. Results. PSM were similar when adjusted for stage, grade, and volume. EBL was significantly less in the RALP (189 ml) group compared to both RPP (475 ml) and RRP (999 ml) groups. When corrected for nerve sparing, there were no differences in erectile function and sexual function amongst the three groups. Urinary summary and pad usage scores showed no significant differences. Conclusion. RPP, RRP, and RALP offer similar surgical and QOL outcomes. RALP and RPP demonstrate less EBL compared to RRP. PMID:22111001

Effect of Pseudomonas fluorescens RB4 and Bacillus subtilis 189 on the phytoremediation potential of Catharanthus roseus (L.) in Cu and Pb-contaminated soils.

PubMed

Khan, Waheed Ullah; Ahmad, Sajid Rashid; Yasin, Nasim Ahmad; Ali, Aamir; Ahmad, Aqeel

2017-06-03

The remediation of heavy metal-contaminated soils has become a critical issue due to toxic effects of these metals on living organisms. The current research was conducted to study the effect of Pseudomonas fluorescens RB4 and Bacillus subtilis 189 on the growth and phytoremediation potential of Catharanthus roseus in Cu- and Pb-contaminated soils. The bacterial strains exhibited significantly higher level of water-extractable Pb and Cu in Pb, Cu, and Cu+Pb-contaminated. The P. fluorescens RB4 inoculated plants, produced 102%, 48%, and 45% higher fresh weight (FW) in soils contaminated with Cu, Pb, and both elements, respectively, as compared to un-inoculated control plants. Similarly, B. subtilis 189 inoculated plants produced 108%, 43%, and 114% more FW in the presence of Cu, Pb, and both elements. The plants co-cultivated with both bacteria exhibited 121%, 102%, and 177% higher FW, in Cu, Pb, and both elements contaminated soils, as compared to respective un-inoculated control. Co-cultivation of P. fluorescens RB4, B. subtilis 189, and P. fluorescens RB4 + B. subtilis 189 resulted in higher accumulation of Cu and Pb in shoots of the C. roseus grown in contaminated soils as compared to un-inoculated control. Bacterial treatments also improved the translocation and metal bioconcentration factors. The growth and phytoextraction capability of C. roseus was improved by inoculation of P. fluorescens RB4 and B. subtilis 189.

A World Fit for Children: Millennium Development Goals; Special Session on Children Documents; The Convention on the Rights of the Child.

ERIC Educational Resources Information Center

United Nations Children's Fund, New York, NY.

In May 2002, participants at the United Nations General Assembly's Special Session on Children committed to a set of specific goals for children and youth and a basic framework for meeting these goals. This report compiles the commitments that were part of the Special Session: (1) the Millennium Development Goals, earlier pledged to by all 189…

Through education we can grow.

PubMed

Pierce, R M

1981-01-01

A Registry Examination for optometric technicians was administered to 189 students and graduate optometric technicians on April 19, 1980. Those who passed this examination will be designated as members of the National paraoptometric Registry. A Registry Examination for optometric assistants is being developed for administration in April 1981. This article will outline how these Registry Examination were developed and what implications they have for the profession. A paraoptometric career ladder will also be presented.

DISSPLA plotting routines for the G-189A EC/LS computer program

NASA Technical Reports Server (NTRS)

Simpson, C. D.

1982-01-01

Data from a G-189A execution is formatted and plotted. The plotting may be done at the time of execution of the program. DISSPLA plot packages are used. The user has the choice of FR80 or TEKTRONIX output.

Increased expression of VEGF121/VEGF165-189 ratio results in a significant enhancement of human prostate tumor angiogenesis.

PubMed

Catena, Raul; Muniz-Medina, Vanessa; Moralejo, Beatriz; Javierre, Biola; Best, Carolyn J M; Emmert-Buck, Michael R; Green, Jeffrey E; Baker, Carl C; Calvo, Alfonso

2007-05-15

Vascular endothelial growth factor (VEGF) is a proangiogenic factor upregulated in many tumors. The alternative splicing of VEGF mRNA renders 3 major isoforms of 121, 165 and 189 amino-acids in humans (1 less amino-acid for each mouse VEGF isoform). We have designed isoform specific real time QRT-PCR assays to quantitate VEGF transcripts in mouse and human normal and malignant prostates. In the human normal prostate, VEGF(165) was the predominant isoform (62.8% +/- 5.2%), followed by VEGF(121) (22.5% +/- 6.3%) and VEGF(189) (p < 0.001) (14.6% +/- 2.1%). Prostate tumors showed a significant increase in the percentage of VEGF(121) and decreases in VEGF(165) (p < 0.01) and VEGF(189) (p < 0.05). However, the amount of total VEGF mRNA was similar between normal and malignant prostates. VEGF(164) was the transcript with the highest expression in the mouse normal prostate. Unlike human prostate cancer, tumors from TRAMP mice demonstrated a significant increase in total VEGF mRNA levels and in each of the VEGF isoforms, without changes in the relative isoform ratios. Morpholino phosphorodiamide antisense oligonucleotide technology was used to increase the relative amount of VEGF(121) while proportionally decreasing VEGF(165) and VEGF(189) levels in human prostate cell lines, through the modification of alternative splicing, without changing transcription levels and total amount of VEGF. The increase in the VEGF(121)/VEGF(165-189) ratio in PC3 cells resulted in a dramatic increase in prostate tumor angiogenesis in vivo. Our results underscore the importance of VEGF(121) in human prostate carcinoma and demonstrate that the relative expression of the different VEGF isoforms has an impact on prostate carcinogenesis. (c) 2007 Wiley-Liss, Inc.

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Airplanes: Turbine engine powered: Takeoff... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Airplanes: Turbine engine powered: Takeoff... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Airplanes: Turbine engine powered: Takeoff... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a...

Plasmodium falciparum Infection Status among Children with Schistosoma in Sub-Saharan Africa: A Systematic Review and Meta-analysis

PubMed Central

Degarege, Abraham; Degarege, Dawit; Veledar, Emir; Erko, Berhanu; Nacher, Mathieu; Beck-Sague, Consuelo M.; Madhivanan, Purnima

2016-01-01

Background It has been suggested that Schistosoma infection may be associated with Plasmodium falciparum infection or related reduction in haemoglobin level, but the nature of this interaction remains unclear. This systematic review synthesized evidence on the relationship of S. haematobium or S. mansoni infection with the occurrence of P. falciparum malaria, Plasmodium density and related reduction in haemoglobin level among children in sub-Saharan Africa (SSA). Methodology/Principal findings A systematic review in according with PRISMA guidelines was conducted. All published articles available in PubMed, Embase, Cochrane library and CINAHL databases before May 20, 2015 were searched without any limits. Two reviewers independently screened, reviewed and assessed all the studies. Cochrane Q and Moran’s I2 were used to assess heterogeneity and the Egger test was used to examine publication bias. The summary odds ratio (OR), summary regression co-efficient (β) and 95% confidence intervals (CI) were estimated using a random-effects model. Out of 2,920 citations screened, 12 articles (five cross-sectional, seven prospective cohort) were eligible to be included in the systematic review and 11 in the meta-analysis. The 12 studies involved 9,337 children in eight SSA countries. Eight studies compared the odds of asymptomatic/uncomplicated P. falciparum infection, two studies compared the incidence of uncomplicated P. falciparum infection, six studies compared P. falciparum density and four studies compared mean haemoglobin level between children infected and uninfected with S. haematobium or S. mansoni. Summary estimates of the eight studies based on 6,018 children showed a higher odds of asymptomatic/uncomplicated P. falciparum infection in children infected with S. mansoni or S. haematobium compared to those uninfected with Schistosoma (summary OR: 1.82; 95%CI: 1.41, 2.35; I2: 52.3%). The increase in odds of asymptomatic/uncomplicated P. falciparum infection among children infected with Schistosoma remained significant when subgroup analysis was conducted for S. haematobium (summary OR: 1.68; 95%CI: 1.18, 2.41; I2: 53.2%) and S. mansoni (summary OR: 2.15; 95%CI: 1.89, 2.46: I2: 0.0%) infection. However, the density of P. falciparum infection was lower in children co-infected with S. haematobium compared to those uninfected with Schistosoma (summary-β: -0.14; 95% CI: -0.24, -0.01; I2: 39.7%). The mean haemoglobin level was higher among children co-infected with S. haematobium and P. falciparum than those infected with only P. falciparum (summary-mean haemoglobin difference: 0.49; 95% CI: 0.04, 0.95; I2: 66.4%) Conclusions/Significance The current review suggests S. mansoni or S. haematobium co-infection may be associated with increased prevalence of asymptomatic/uncomplicated P. falciparum infection in children, but may protect against high density P. falciparum infection and related reduction in haemoglobin level. PMID:27926919

Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity.

PubMed

Seidman, M M; Bredberg, A; Seetharam, S; Kraemer, K H

1987-07-01

Mutagenesis was studied at the DNA-sequence level in human fibroblast and lymphoid cells by use of a shuttle vector plasmid, pZ189, containing a suppressor tRNA marker gene. In a series of experiments, 62 plasmids were recovered that had two to six base substitutions in the 160-base-pair marker gene. Approximately 20-30% of the mutant plasmids that were recovered after passing ultraviolet-treated pZ189 through a repair-proficient human fibroblast line contained these multiple mutations. In contrast, passage of ultraviolet-treated pZ189 through an excision-repair-deficient (xeroderma pigmentosum) line yielded only 2% multiple base substitution mutants. Introducing a single-strand nick in otherwise unmodified pZ189 adjacent to the marker, followed by passage through the xeroderma pigmentosum cells, resulted in about 66% multiple base substitution mutants. The multiple mutations were found in a 160-base-pair region containing the marker gene but were rarely found in an adjacent 170-base-pair region. Passing ultraviolet-treated or nicked pZ189 through a repair-proficient human B-cell line also yielded multiple base substitution mutations in 20-33% of the mutant plasmids. An explanation for these multiple mutations is that they were generated by an error-prone polymerase while filling gaps. These mutations share many of the properties displayed by mutations in the immunoglobulin hypervariable regions.

Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist

PubMed Central

Bu, Wei; Ren, Huiling; Deng, Yunping; Del Mar, Nobel; Guley, Natalie M.; Moore, Bob M.; Honig, Marcia G.; Reiner, Anton

2016-01-01

We have previously reported that mild TBI created by focal left-side cranial blast in mice produces widespread axonal injury, microglial activation, and a variety of functional deficits. We have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid type-2 (CB2) receptors using 2-week daily administration of the CB2 inverse agonist SMM-189. CB2 inverse agonists stabilize the G-protein coupled CB2 receptor in an inactive conformation, leading to increased phosphorylation and nuclear translocation of the cAMP response element binding protein (CREB), and thus bias activated microglia from a pro-inflammatory M1 to a pro-healing M2 state. In the present study, we showed that SMM-189 boosts nuclear pCREB levels in microglia in several brain regions by 3 days after TBI, by using pCREB/CD68 double immunofluorescent labeling. Next, to better understand the basis of motor deficits and increased fearfulness after TBI, we used unbiased stereological methods to characterize neuronal loss in cortex, striatum, and basolateral amygdala (BLA) and assessed how neuronal loss was affected by SMM-189 treatment. Our stereological neuron counts revealed a 20% reduction in cortical and 30% reduction in striatal neurons bilaterally at 2–3 months post blast, with SMM-189 yielding about 50% rescue. Loss of BLA neurons was restricted to the blast side, with 33% of Thy1+ fear-suppressing pyramidal neurons and 47% of fear-suppressing parvalbuminergic (PARV) interneurons lost, and Thy1-negative fear-promoting pyramidal neurons not significantly affected. SMM-189 yielded 50–60% rescue of Thy1+ and PARV neuron loss in BLA. Thus, fearfulness after mild TBI may result from the loss of fear-suppressing neuron types in BLA, and SMM-189 may reduce fearfulness by their rescue. Overall, our findings indicate that SMM-189 rescues damaged neurons and thereby alleviates functional deficits resulting from TBI, apparently by selectively modulating microglia to the beneficial M2 state. CB2 inverse agonists thus represent a promising therapeutic approach for mitigating neuroinflammation and neurodegeneration. PMID:27766068

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2011 CFR

2011-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189.180 Safrole. (a) Safrole is the chemical 4-allyl-1,2...

Y-STR INRA189 polymorphisms in Chinese yak breeds.

PubMed

Ma, Z J; Chen, S M; Sun, Y G; Xi, Y L; Li, R Z; Xu, J T; Lei, C Z

2015-12-29

To further explore Y-STR INRA189 polymorphisms in the yak, and to determine the genetic differences among yak breeds, genotyping analysis of INRA189 in 102 male yak individuals from three yak breeds in Qinghai Province of China was performed. Genotyping revealed the presence of four alleles, with sizes of 149, 155, 157, and 159 bp, respectively. Of these, the 157-bp allele, which was found with the highest frequency in the three yak breeds, was the dominant allele. Interestingly, the 149-bp allele was only detected in the Gaoyuan breed, and the 159-bp allele was only found in the Huanhu and Datong breeds. Only the 157- and 155-bp alleles were found in all three yak breeds. Taking the three yak breeds as a single population, the frequency of these four alleles was 0.0294, 0.0686, 0.8628, and 0.0392, respectively. The average polymorphism information content in the three yak breeds was 0.2379, indicating that the INRA189 was a low polymorphic Y-STR marker in yak.

MANUAL: BEST MANAGEMENT PRACTICES FOR POLLUTION PREVENTION IN THE SLABSTOCK AND MOLDED FLEXIBLE POLYURETHANE FOAM INDUSTRY

EPA Science Inventory

The 1990 Clean Air Act Amendments require EPA to develop standards for major emission sources of 189 hazardous air pollutants (HAPs). EPA has identified the flexible polyurethane foam industry as a large emitter of HAPs and has slated the industry for regulation under Title III, ...

Integrating Requirements Engineering, Modeling, and Verification Technologies into Software and Systems Engineering

DTIC Science & Technology

2007-10-28

Software Engineering, FASE󈧉, volume 3442 of Lecture Notes in Computer Science, pages 175--189. Springer, 2005. Andreas Bauer, Martin Leucker, and Jonathan ...of Personnel receiving masters degrees NAME Markus Strohmeier Gerrit Hanselmann Jonathan Streit Ernst Sassen 4Total Number: Names of personnel...developed and documented mainly within the master thesis by Jonathan Streit [Str06]: • Jonathan Streit. Development of a programming language like tem

G-189A analytical simulation of the integrated waste management-water system using radioisotopes for thermal energy

NASA Technical Reports Server (NTRS)

Coggi, J. V.; Loscutoff, A. V.; Barker, R. S.

1973-01-01

An analytical simulation of the RITE-Integrated Waste Management and Water Recovery System using radioisotopes for thermal energy was prepared for the NASA-Manned Space Flight Center (MSFC). The RITE system is the most advanced concept water-waste management system currently under development and has undergone extended duration testing. It has the capability of disposing of nearly all spacecraft wastes including feces and trash and of recovering water from usual waste water sources: urine, condensate, wash water, etc. All of the process heat normally used in the system is produced from low penalty radioisotope heat sources. The analytical simulation was developed with the G189A computer program. The objective of the simulation was to obtain an analytical simulation which can be used to (1) evaluate the current RITE system steady state and transient performance during normal operating conditions, and also during off normal operating conditions including failure modes; and (2) evaluate the effects of variations in component design parameters and vehicle interface parameters on system performance.

PHOTOGRAPH NUMBERS 40, 39, 38 FORM A 189 DEGREE PANORAMA ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PHOTOGRAPH NUMBERS 40, 39, 38 FORM A 189 DEGREE PANORAMA FROM LEFT TO RIGHT. PHOTOGRAPH NUMBER 38 LOOKING NORTHEAST TO SKYLINE FROM ROOF OF POLSON BUILDING; PHOTOGRAPH NUMBER 39 VIEW NORTH; PHOTOGRAPH NUMBER 40 VIEW NORTHWEST. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

46 CFR 189.25-20 - Fire extinguishing equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire extinguishing equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire extinguishing equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire-extinguishing equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire-extinguishing equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

Publications - GMC 189 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 189 Publication Details Title: Apatite and zircon fission track analyses of 9 selected wells analyses of 9 selected wells in the NPRA, Alaska: Alaska Division of Geological & Geophysical Surveys

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Airplanes: Turbine engine powered: Takeoff... Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a turbine engine powered airplane may take off that airplane at a weight greater than that listed in the...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplanes: Turbine engine powered: Takeoff... Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a turbine engine powered airplane may take off that airplane at a weight greater than that listed in the...

78 FR 38922 - Foreign-Trade Zone 189-Kent/Ottawa/Muskegon Counties, Michigan; Authorization of Production...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-19-2013] Foreign-Trade Zone 189--Kent/Ottawa/Muskegon Counties, Michigan; Authorization of Production Activity; Southern Lithoplate, Inc. (Aluminum Printing Plates); Grand Rapids, Michigan On February 22, 2013, Southern Lithoplate, Inc. submitted a...

14 CFR 91.189 - Category II and III operations: General operating rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... pilot who is controlling the aircraft has appropriate instrumentation for the type of flight control... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Flight Rules Instrument Flight Rules § 91.189 Category II and III operations: General operating rules. (a) No...

14 CFR 91.189 - Category II and III operations: General operating rules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... pilot who is controlling the aircraft has appropriate instrumentation for the type of flight control... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Flight Rules Instrument Flight Rules § 91.189 Category II and III operations: General operating rules. (a) No...

14 CFR 91.189 - Category II and III operations: General operating rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... pilot who is controlling the aircraft has appropriate instrumentation for the type of flight control... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Flight Rules Instrument Flight Rules § 91.189 Category II and III operations: General operating rules. (a) No...

28 CFR 115.189 - Data storage, publication, and destruction.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Data storage, publication, and... ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Data Collection and Review § 115.189 Data storage, publication, and destruction. (a) The agency shall ensure that data collected pursuant to § 115.187 are...

28 CFR 115.189 - Data storage, publication, and destruction.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Data storage, publication, and... ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Data Collection and Review § 115.189 Data storage, publication, and destruction. (a) The agency shall ensure that data collected pursuant to § 115.187 are...

28 CFR 115.189 - Data storage, publication, and destruction.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Data storage, publication, and... ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Data Collection and Review § 115.189 Data storage, publication, and destruction. (a) The agency shall ensure that data collected pursuant to § 115.187 are...

46 CFR 189.35-90 - Weight handling gear manufactured prior to March 1, 1968.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Weight Handling Gear § 189.35-90 Weight handling..., will be accepted on the basis of appropriate tests and examinations should plans or other technical...

Ultraviolet mutagenesis in a plasmid vector replicated in lymphoid cells from patient with the melanoma-prone disorder dysplastic nevus syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seetharam, S.; Waters, H.L.; Seidman, M.M.

The hereditary dysplastic nevus syndrome (DNS) is an autosomal dominant disorder in which affected individuals have increased numbers of dysplastic (premalignant) nevi and a greater than 100-fold increased risk of developing cutaneous melanoma. Epstein-Barr virus-transformed lymphoblastoid cell lines from patients with hereditary DNS have been shown to be hypermutable to UV radiation. To examine the mechanism involved in this UV hypermutability, we used a shuttle vector plasmid, pZ189, which carries a 160-base pair marker gene, supF, and can replicate in human cells. pZ189 was treated with UV radiation and transfected into DNS6BE, a lymphoblastoid cell line from a patient withmore » hereditary DNS. Plasmid survival after UV was similar with the DNS6BE line and with a lymphoblastoid cell line from a normal donor. Plasmid mutation frequency was greater with the DNS line in accord with the DNS cellular hypermutability. Base sequence analysis was performed on 69 mutated plasmids recovered from the DNS line. There were significantly more plasmids with single base substitution mutations (P less than 0.01) in comparison to UV-treated plasmids passed through normal fibroblasts. pZ189 hypermutability and an increased frequency of single base substitutions was previously found with a cell line from a melanoma-prone xeroderma pigmentosum patient. These differences may be related to the increased melanoma susceptibility in both DNS and xeroderma pigmentosum.« less

Shape-Coexistence in ^191Tl and ^189Tl.

NASA Astrophysics Data System (ADS)

Reviol, W.; Riedinger, L. L.; Carpenter, M. P.; Fischer, S. M.; Janssens, R. V. F.; Nisius, D.; Moore, E. F.

1997-10-01

The Tl isotopes at A ~ 190 are, like the neighboring Hg and Pb nuclei, recognized for a multiplicity of shapes. These shapes reach from spherical or weakly deformed oblate to well-deformed and superdeformed prolate, as mainly inferred from γ -ray spectroscopic studies. We have previously reported on shape-coexistence phenomena in ^191Tl and ^189Tl(W. Reviol et al., Phys. Scr. T56, 167 (1995), and references therein.). Here, we will focus on new results on the ``normally" deformed states in both nuclei obtained from a recent and an upcoming experiment at GAMMASPHERE. The states in ^191Tl and ^189Tl are populated by the reactions ^159Tb(^36S,4n)^191Tl at E_lab = 165 MeV and ^156Gd(^37Cl,4n)^189Tl at E_lab = 171 MeV, respectively. One of the questions to be addressed is about the main level structure in the positive-parity branch of ^191Tl^2. Whether this structure is oblate-collective in nature, like the [505]9/2^- yrast band, we will try to answer on the basis of the available lifetime data.

Gender Differences in the Development of Managers: How Women Managers Learn from Experience.

ERIC Educational Resources Information Center

Van Velsor, Ellen; Hughes, Martha W.

This study investigated gender differences associated with experiential learning. The data come from two studies of general management level men and women. The first, conducted between 1981 and 1984, involved 189 men and 2 women, and utilized interviews and questionnaires. In 1984-85, a second study interviewed 76 women. In each study, managers…

The Case Study Method: Guidelines, Practices, and Applications for Vocational Education. Research and Development Series No. 189.

ERIC Educational Resources Information Center

Spirer, Janet E.

In comparison with traditional experimental design, which is concerned with what happened, a case study approach is more appropriate for answering the question of why or how something happened. As an alternative complementary-vocational-education-evaluation approach, the case study attempts to describe and analyze some program in comprehensive…

Child Development Programs (CDPs)

DTIC Science & Technology

1993-01-19

Child Abuse Training Modules for Caregivers, DoD Child Abuse Training Modules for Family Child Care Providers, DoD Family Child Care Training Modules, DoD CDP Standards and Inspection Checklist, DoD Child Development Need Survey, The DoD School-Age Care Training Modules, and DD Form 2636, DoD Certificate to Operate Child Development Programs, consistent with reference (9). 4. Implements Pub. L. No. 101-189, Title XV (reference (h)). 5. Replaces references (i) through

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

12. General Arrangement Plan, Building 189D, U.S. Atomic Energy Commission, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. General Arrangement Plan, Building 189-D, U.S. Atomic Energy Commission, General Electric Company, Dwg. No. H-1-11068, 1958. - D-Reactor Complex, Deaeration Plant-Refrigeration Buildings, Area 100-D, Richland, Benton County, WA

The Effects of the Science Curriculum Improvement Study on a Child's Self-Concept

ERIC Educational Resources Information Center

Krockover, Gerald H.; Malcolm, Marshall D.

1977-01-01

Describes research undertaken to determine if Science Curriculum Improvement Study (SCIS) can be instrumental in helping children either maintain or develop a positive self-concept. A total of 189 students in grades 3-6 were assigned to treatment and control groups for a period of four and one-half months. Findings did not reveal overall…

49 CFR 192.189 - Vaults: Drainage and waterproofing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.189 Vaults: Drainage and waterproofing. (a) Each vault must be designed so as to minimize... applicable requirements of Class 1, Group D, of the National Electrical Code, ANSI/NFPA 70. [35 FR 13257, Aug...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

Development and Experimental Operation of a Flashboard Plasma Cathode Test Stand

DTIC Science & Technology

2012-06-01

grid-controlled system [31]. J.R. Bayless and his group developed a new type of plasma cathode electron gun qualified for pulsed and continuous...Interferometry of flashboard and cable- gun plasma opening switches on hawk,” IEEE Trans. Plasma Sci., vol. 25, no. 2, pp. 189–195, Apr. 1997. [29] C...The plasma -cathode electron gun ,” IEEE Journal of Quantum Electronics, vol. 10, no. 2, pp. 213–218, Feb 1974. [33] Ady Hershcovitch

21 CFR 1303.22 - Procedure for applying for individual manufacturing quotas.

Code of Federal Regulations, 2010 CFR

2010-04-01

... manufacturing quotas. Any person who is registered to manufacture any basic class of controlled substance listed in Schedule I or II and who desires to manufacture a quantity of such class shall apply on DEA Form 189 for a manufacturing quota for such quantity of such class. Copies of DEA Form 189 may be obtained...

Analysis and Design of Crew Sleep Station for ISS

NASA Technical Reports Server (NTRS)

Keener, John F.; Paul, Thomas; Eckhardt, Bradley; Smith, Fredrick

2002-01-01

This paper details the analysis and design of the Temporary Sleep Station (TeSS) environmental control system for International Space Station (ISS). The TeSS will provide crewmembers with a private and personal space, to accommodate sleeping, donning and doffing of clothing, personal communication and performance of recreational activities. The need for privacy to accommodate these activities requires adequate ventilation inside the TeSS. This study considers whether temperature, carbon dioxide, and humidity within the TeSS remain within crew comfort and safety levels for various expected operating scenarios. Evaluation of these scenarios required the use and integration of various simulation codes. An approach was adapted for this study, whereby results from a particular code were integrated with other codes when necessary. Computational Fluid Dynamics (CFD) methods were used to evaluate the flow field inside the TeSS, from which local gradients for temperature, velocity, and species concentration such as CO (sub 2) could be determined. A model of the TeSS, containing a human, as well as equipment such as a laptop computer, was developed in FLUENT, a finite-volume code. Other factors, such as detailed analysis of the heat transfer through the structure, radiation, and air circulation from the TeSS to the US Laboratory Aisle, where the TeSS is housed, were considered in the model. A complementary model was developed in G189A, a code which has been used by NASA/JSC for environmental control systems analyses since the Apollo program. Boundary conditions were exchanged between the FLUENT and G189A TeSS models. G189A provides human respiration rates to the FLUENT model, while the FLUENT model provides local convective heat transfer coefficients to G189A model. An additional benefit from using an approach with both a systems simulation and CFD model, is the capability to verify the results of each model by comparison to the results of the other model. The G189A and FLUENT models were used to evaluate various ventilation designs for the TeSS over a range of operating conditions with varying crew metabolic load, equipment operating modes, ventilation flow rates, and with the TeSS doors open and closed. Results from the study were instrumental in the optimization of a design for the TeSS ventilation hardware. A special case was considered where failure of the TeSS ventilation system occurred. In this case, a study was conducted in order to determine the time required for the CO (sub 2) concentration inside the TeSS to increase to ISS limit values under transient conditions. A lumped-capacitance code, SINDA-FLUINT was used in this case to provide accurate predictions of the human reaction to the TeSS cabin conditions including core and skin temperatures and body heat storage. A simple two-dimensional CFD model of a crewmember inside the TeSS was developed in FLUENT in order to determine the volume envelope of the respired air from the human, which maintained a minimum velocity profile. This volume was then used in the SINDA-FLUINT model to facilitate the calculations of CO (sub 2) concentrations, dry bulb temperatures and humidity levels inside the TeSS.

A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice.

PubMed

Qin, Yangjun; Poirier, Christophe; Truong, Cavatina; Schumacher, Armin; Agoulnik, Alexander I; Bishop, Colin E

2003-03-01

We have previously reported a dominant mouse mutant, Odd sex (Ods), in which XX Ods/+ mice on the FVB/N background show complete sex reversal, associated with expression of Sox9 in the fetal gonads. Remarkably, when crossed to the A/J strain approximately 95% of the (AXFVB) F(1) XX Ods/+ mice developed as fully fertile, phenotypic females, the remainder developing as males or hermaphrodites. Using a (AXFVB) F(2) population, we conducted a genome-wide linkage scan to identify the number and chromosomal location of potential Ods modifier genes. A single major locus termed Odsm1 was mapped to chromosome 18, tightly linked to D18Mit189 and D18Mit210. Segregation at this locus could account for the presence of sex reversal in 100% of XX Ods/+ mice which develop as males, for the absence of sex reversal in approximately 92% of XX Ods/+ mice which develop as females, and for the mixed sexual phenotype in approximately 72% of XX Ods/+ mice that develop with ambiguous genitalia. We propose that homozygosity for the FVB-derived allele strongly favors Ods sex reversal, whereas homozygosity for the A/J-derived allele inhibits it. In mice heterozygous at Odsm1, the phenotypic outcome, male, female or hermaphrodite, is determined by a complex interaction of several minor modifying loci. The close proximity of Smad2, Smad7 and Smad4 to D18Mit189/210 provides a potential mechanism through which Odsm1 might act.

An Analysis of Coast Guard HH-65 Engine Reliability: A Comparison of Malfunctions to Component Removals

DTIC Science & Technology

2004-03-01

developed while the HH-65 was still in the developmental phase and a Full Authority Digital Engine Control ( FADEC ) system (Chisom, 1984:189). In 1982...Lucas Aerospace developed a FADEC system for the HH-65. While test flights of this system were successful in demonstrating the feasibility of the...Lucas FADEC for the HH-65, there were problems associated with a lack of redundancy of the Engine Control Computer software and lack of cockpit

THE DEVELOPMENT AND BACKGROUND OF THE POSITION ANALYSIS QUESTIONNAIRE

DTIC Science & Technology

The report deals with the background and the development of the Position Analysis Questionnaire ( PAQ ), which was used as the basic job analysis...instrument in the research program. The PAQ (Form A) used in the study includes 189 job elements of an essentially ’worker-oriented’ nature, these elements...characterize certain aspects of the context within which human work is performed. The job elements of the PAQ have been used as the basis for deriving various

1. 185/189D in center, north end west facades (190D front ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. 185/189-D in center, north end west facades (190-D front left and west facade; 195-D rear right). Looking south. - D-Reactor Complex, Deaeration Plant-Refrigeration Buildings, Area 100-D, Richland, Benton County, WA

Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells

PubMed Central

Fink, Brian D.; Herlein, Judith A.; Yorek, Mark A.; Fenner, Amanda M.; Kerns, Robert J.

2012-01-01

Mitochondrial-targeted analogs of coenzyme Q (CoQ) are under development to reduce oxidative damage induced by a variety of disease states. However, there is a need to understand the bioenergetic effects of these agents and whether or not these effects are related to redox properties, including their known pro-oxidant effects. We examined the bioenergetic effects of two mitochondrial-targeted CoQ analogs in their quinol forms, mitoquinol (MitoQ) and plastoquinonyl-decyl-triphenylphosphonium (SkQ1), in bovine aortic endothelial cells. We used an extracellular oxygen and proton flux analyzer to assess mitochondrial action at the intact-cell level. Both agents, in dose-dependent fashion, reduced the oxygen consumption rate (OCR) directed at ATP turnover (OCRATP) (IC50 values of 189 ± 13 nM for MitoQ and 181 ± 7 for SKQ1; difference not significant) while not affecting or mildly increasing basal oxygen consumption. Both compounds increased extracellular acidification in the basal state consistent with enhanced glycolysis. Both compounds enhanced mitochondrial superoxide production assessed by using mitochondrial-targeted dihydroethidium, and both increased H2O2 production from mitochondria of cells treated before isolation of the organelles. The manganese superoxide dismutase mimetic manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin did not alter or actually enhanced the actions of the targeted CoQ analogs to reduce OCRATP. In contrast, N-acetylcysteine mitigated this effect of MitoQ and SkQ1. In summary, our data demonstrate the important bioenergetic effects of targeted CoQ analogs. Moreover, these effects are mediated, at least in part, through superoxide production but depend on conversion to H2O2. These bioenergetic and redox actions need to be considered as these compounds are developed for therapeutic purposes. PMID:22661629

Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells.

PubMed

Fink, Brian D; Herlein, Judith A; Yorek, Mark A; Fenner, Amanda M; Kerns, Robert J; Sivitz, William I

2012-09-01

Mitochondrial-targeted analogs of coenzyme Q (CoQ) are under development to reduce oxidative damage induced by a variety of disease states. However, there is a need to understand the bioenergetic effects of these agents and whether or not these effects are related to redox properties, including their known pro-oxidant effects. We examined the bioenergetic effects of two mitochondrial-targeted CoQ analogs in their quinol forms, mitoquinol (MitoQ) and plastoquinonyl-decyl-triphenylphosphonium (SkQ1), in bovine aortic endothelial cells. We used an extracellular oxygen and proton flux analyzer to assess mitochondrial action at the intact-cell level. Both agents, in dose-dependent fashion, reduced the oxygen consumption rate (OCR) directed at ATP turnover (OCR(ATP)) (IC₅₀ values of 189 ± 13 nM for MitoQ and 181 ± 7 for SKQ1; difference not significant) while not affecting or mildly increasing basal oxygen consumption. Both compounds increased extracellular acidification in the basal state consistent with enhanced glycolysis. Both compounds enhanced mitochondrial superoxide production assessed by using mitochondrial-targeted dihydroethidium, and both increased H₂O₂ production from mitochondria of cells treated before isolation of the organelles. The manganese superoxide dismutase mimetic manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin did not alter or actually enhanced the actions of the targeted CoQ analogs to reduce OCR(ATP). In contrast, N-acetylcysteine mitigated this effect of MitoQ and SkQ1. In summary, our data demonstrate the important bioenergetic effects of targeted CoQ analogs. Moreover, these effects are mediated, at least in part, through superoxide production but depend on conversion to H₂O₂. These bioenergetic and redox actions need to be considered as these compounds are developed for therapeutic purposes.

R-189 (C-620) air compressor control logic software documentation. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walter, K.E.

1995-06-08

This relates to FFTF plant air compressors. Purpose of this document is to provide an updated Computer Software Description for the software to be used on R-189 (C-620-C) air compressor programmable controllers. Logic software design changes were required to allow automatic starting of a compressor that had not been previously started.

Development Genetic Analysis of General Cognitive Ability from 1 to 12 Years in a Sample of Adoptees, Biological Siblings, and Twins.

ERIC Educational Resources Information Center

Bishop, E. G.; Cherny, Stacey S.; Corley, Robin; Plomin, Robert; DeFries, John C.; Hewitt, John K.

2003-01-01

Studied continuity and change in general cognitive ability from infancy to adolescence in adoptees (107 children), biological siblings (87 pairs), and twins (224 monozygotic and 189 dyzygotic pairs). Findings generally support previous findings about genetic and environmental factors, with the exception that in the transition to adolescence,…

A Catalogue of Data in the Statistical Information Centre, March 1976. (Catalogue de donnees du Centre d'information statistique, Mars 1976.)

ERIC Educational Resources Information Center

Department of Indian Affairs and Northern Development, Ottawa (Ontario).

Over 189 materials which cover aspects of the Administration, Parks Canada, Indian and Eskimo Affairs, and Northern Development Programs are cited in this bilingual catalogue (English and French). Information given for each entry is: reference number, statistics available, years covered, and whether the statistics are available by area, region,…

What Are Extraordinary Gifted Children like (Equal to or above 189 IQ)? A Study of 10 Cases

ERIC Educational Resources Information Center

Mate, Yolanda Benito

2009-01-01

After a short introduction about previous studies on extraordinarily gifted children with an IQ of over 170, this article refers to the descriptive characteristics of ten children with IQ of over 189. After this, the developmental and learning characteristics of these children are described and finally empirical research about aspects that…

21 CFR 189.301 - Tin-coated lead foil capsules for wine bottles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Tin-coated lead foil capsules for wine bottles... Substances Prohibited From Indirect Addition to Human Food Through Food-Contact Surfaces § 189.301 Tin-coated lead foil capsules for wine bottles. (a) Tin-coated lead foil is composed of a lead foil coated on one...

21 CFR 189.301 - Tin-coated lead foil capsules for wine bottles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Tin-coated lead foil capsules for wine bottles... Substances Prohibited From Indirect Addition to Human Food Through Food-Contact Surfaces § 189.301 Tin-coated lead foil capsules for wine bottles. (a) Tin-coated lead foil is composed of a lead foil coated on one...

21 CFR 189.301 - Tin-coated lead foil capsules for wine bottles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Tin-coated lead foil capsules for wine bottles... Substances Prohibited From Indirect Addition to Human Food Through Food-Contact Surfaces § 189.301 Tin-coated lead foil capsules for wine bottles. (a) Tin-coated lead foil is composed of a lead foil coated on one...

21 CFR 1303.22 - Procedure for applying for individual manufacturing quotas.

Code of Federal Regulations, 2011 CFR

2011-04-01

... in Schedule I or II and who desires to manufacture a quantity of such class shall apply on DEA Form 189 for a manufacturing quota for such quantity of such class. Copies of DEA Form 189 may be obtained... Administration. See the Table of DEA Mailing Addresses in § 1321.01 of this chapter for the current mailing...

Examining the Epistemological Beliefs and Problem Solving Skills of Preservice Teachers during Teaching Practice

ERIC Educational Resources Information Center

Erdamar, Gurcu; Alpan, Gulgun

2013-01-01

This study aims to examine the development of preservice teachers' epistemological beliefs and problem solving skills in the process of teaching practice. Participants of this descriptive study were senior students from Gazi University's Faculty of Vocational Education ("n" = 189). They completed the Epistemological Belief Scale and…

Small Schools Mathematics Curriculum, 9-12: Scope Objectives, Activities, Resources, Monitoring Procedures.

ERIC Educational Resources Information Center

Nelson, JoAnne, Ed.; And Others

The grade 9-12 mathematics curriculum learning objectives, activities, monitoring procedures and resources for small schools were developed during 1978-79 through the cooperative efforts of 10 Snohomish and Island County school districts, Educational Service District 189 and the Washington State Office of Public Instruction. The objectives were…

Estimation of Δ R/ R values by benchmark study of the Mössbauer Isomer shifts for Ru, Os complexes using relativistic DFT calculations

NASA Astrophysics Data System (ADS)

Kaneko, Masashi; Yasuhara, Hiroki; Miyashita, Sunao; Nakashima, Satoru

2017-11-01

The present study applies all-electron relativistic DFT calculation with Douglas-Kroll-Hess (DKH) Hamiltonian to each ten sets of Ru and Os compounds. We perform the benchmark investigation of three density functionals (BP86, B3LYP and B2PLYP) using segmented all-electron relativistically contracted (SARC) basis set with the experimental Mössbauer isomer shifts for 99Ru and 189Os nuclides. Geometry optimizations at BP86 theory of level locate the structure in a local minimum. We calculate the contact density to the wavefunction obtained by a single point calculation. All functionals show the good linear correlation with experimental isomer shifts for both 99Ru and 189Os. Especially, B3LYP functional gives a stronger correlation compared to BP86 and B2PLYP functionals. The comparison of contact density between SARC and well-tempered basis set (WTBS) indicated that the numerical convergence of contact density cannot be obtained, but the reproducibility is less sensitive to the choice of basis set. We also estimate the values of Δ R/ R, which is an important nuclear constant, for 99Ru and 189Os nuclides by using the benchmark results. The sign of the calculated Δ R/ R values is consistent with the predicted data for 99Ru and 189Os. We obtain computationally the Δ R/ R values of 99Ru and 189Os (36.2 keV) as 2.35×10-4 and -0.20×10-4, respectively, at B3LYP level for SARC basis set.

21 CFR 189.301 - Tin-coated lead foil capsules for wine bottles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Tin-coated lead foil capsules for wine bottles... Addition to Human Food Through Food-Contact Surfaces § 189.301 Tin-coated lead foil capsules for wine bottles. (a) Tin-coated lead foil is composed of a lead foil coated on one or both sides with a thin layer...

189. Photographic copy of original construction drawing dated December 10, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

189. Photographic copy of original construction drawing dated December 10, 1932 (from Record Group 115, Denver Branch of the National Archives, Denver). TUNNEL NO.1 CONTROLLING WORKS; WATER TIGHT DOOR; CHANNEL VENT INLETS-PIER NOSE ANGLES. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

46 CFR 189.55-5 - Plans and specifications required for new construction.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Plan Approval § 189.55-5 Plans and specifications..., carbon dioxide, foam and sprinkling systems. (e) Marine engineering. For plans required for marine engineering equipment and systems. See Subchapter F (Marine Engineering) of this chapter. (f) Electrical...

46 CFR 189.55-5 - Plans and specifications required for new construction.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Plan Approval § 189.55-5 Plans and specifications..., carbon dioxide, foam and sprinkling systems. (e) Marine engineering. For plans required for marine engineering equipment and systems. See Subchapter F (Marine Engineering) of this chapter. (f) Electrical...

20 CFR 661.400 - What is the purpose of the General Statutory and Regulatory Waiver Authority provided at section...

Code of Federal Regulations, 2010 CFR

2010-04-01

... and Regulatory Waiver Authority provided at section 189(i)(4) of the Workforce Investment Act? 661.400... AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT... Authority provided at section 189(i)(4) of the Workforce Investment Act? (a) The purpose of the general...

Criticality Safety Basics for INL FMHs and CSOs

DOE Office of Scientific and Technical Information (OSTI.GOV)

V. L. Putman

2012-04-01

Nuclear power is a valuable and efficient energy alternative in our energy-intensive society. However, material that can generate nuclear power has properties that require this material be handled with caution. If improperly handled, a criticality accident could result, which could severely harm workers. This document is a modular self-study guide about Criticality Safety Principles. This guide's purpose it to help you work safely in areas where fissionable nuclear materials may be present, avoiding the severe radiological and programmatic impacts of a criticality accident. It is designed to stress the fundamental physical concepts behind criticality controls and the importance of criticalitymore » safety when handling fissionable materials outside nuclear reactors. This study guide was developed for fissionable-material-handler and criticality-safety-officer candidates to use with related web-based course 00INL189, BEA Criticality Safety Principles, and to help prepare for the course exams. These individuals must understand basic information presented here. This guide may also be useful to other Idaho National Laboratory personnel who must know criticality safety basics to perform their assignments safely or to design critically safe equipment or operations. This guide also includes additional information that will not be included in 00INL189 tests. The additional information is in appendices and paragraphs with headings that begin with 'Did you know,' or with, 'Been there Done that'. Fissionable-material-handler and criticality-safety-officer candidates may review additional information at their own discretion. This guide is revised as needed to reflect program changes, user requests, and better information. Issued in 2006, Revision 0 established the basic text and integrated various programs from former contractors. Revision 1 incorporates operation and program changes implemented since 2006. It also incorporates suggestions, clarifications, and additional information from readers and from personnel who took course 00INL189. Revision 1 also completely reorganized the training to better emphasize physical concepts behind the criticality controls that fissionable material handlers and criticality safety officers must understand. The reorganization is based on and consistent with changes made to course 00INL189 due to a review of course exam results and to discussions with personnel who conduct area-specific training.« less

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bredberg, A.; Kraemer, K.H.; Seidman, M.M.

1986-11-01

A shuttle vector plasmid, pZ189, carrying a bacterial suppressor tRNA marker gene, was treated with ultraviolet radiation and propagated in cultured skin cells from a patient with the skin-cancer-prone, DNA repair-deficient disease xeroderma pigmentosum and in repair-proficient cells. After replication in the human cells, progeny plasmids were purified. Plasmid survival and mutations inactivating the marker gene were scored by transforming an indicator strain of Escherichia coli carrying a suppressible amber mutation in the beta-galactosidase gene. Plasmid survival in the xeroderma pigmentosum cells was less than that of pZ189 harvested from repair-proficient human cells. The point-mutation frequency in the 150-base-pair tRNAmore » marker gene increased up to 100-fold with ultraviolet dose. Sequence analysis of 150 mutant plasmids revealed that mutations were infrequent at potential thymine-thymine dimer sites. Ninety-three percent of the mutant plasmids from the xeroderma pigmentosum cells showed G X C----A X T transitions, compared to 73% in the normal cells (P less than 0.002). There were significantly fewer transversions (P less than 0.002) (especially G X C----T X A) and multiple base substitutions (P less than 0.00001) than when pZ189 was passaged in repair-proficient cells. The subset of mutational changes that are common to ultraviolet-treated plasmids propagated in both repair-proficient and xeroderma pigmentosum skin cells may be associated with the development of ultraviolet-induced skin cancer in humans.« less

50 CFR 216.189 - Renewal of Letters of Authorization.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Array Sensor System Low Frequency Active (SURTASS LFA sonar) Sonar § 216.189 Renewal of Letters of... each SURTASS LFA sonar operation; (3) Timely receipt of the monitoring reports required under § 216.185... comment on the proposed modification. Amending the areas for upcoming SURTASS LFA sonar operations is not...

50 CFR 216.189 - Renewal of Letters of Authorization.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Array Sensor System Low Frequency Active (SURTASS LFA sonar) Sonar § 216.189 Renewal of Letters of... each SURTASS LFA sonar operation; (3) Timely receipt of the monitoring reports required under § 216.185... comment on the proposed modification. Amending the areas for upcoming SURTASS LFA sonar operations is not...

189. Photocopy of drawing, Twin Falls Canal Company, date unknown. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

189. Photocopy of drawing, Twin Falls Canal Company, date unknown. ROCK CREEK CROSSING, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; BLUEPRINT. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

Effect of Back Massage Intervention on Anxiety, Comfort, and Physiologic Responses in Patients with Congestive Heart Failure

PubMed Central

Chen, Wei-Ling; Liu, Gin-Jen; Chiang, Ming-Chu; Fu, Mao-Young; Hsieh, Yuan-Kai

2013-01-01

Abstract Background Patients suffering from congestive heart failure (CHF) frequently feel physical suffering and anxiety. Objectives The researchers investigated whether back massage could reduce anxiety, discomfort, and physical suffering in patients with CHF. The effects of gender and severity-dependent response of back massage on anxiety and discomfort in patients were also analyzed. Design The study used a quasi-experimental design with one group pretest and posttest. Participants Sixty-four participants were recruited in southern Taiwan. Outcome measures The modified State Anxiety Inventory, the discomfort Visual Analogue Scale, electronic blood pressure (BP) gauges, stethoscopes and the pulse oximetry were used in this study. Results The participants' systolic BP (F (3, 189)=18.91, p<0.01), diastolic BP (F (3, 189)=13.40, p<0.01), heart rate (F (3, 189)=26.28, p<0.01), and respiratory rates (F (3, 189)=5.77, p<0.01) were significantly decreased after back massage. Oxygen saturation levels showed significant increases (F (3, 189)=42.82, p<0.01). Male participants revealed a more significant reduction in anxiety than the female participants (F (1, 50)=7.27, p=0.01). Those with more severe heart failure and greater levels of anxiety (F (2, 61)=4.31, p=0.02) and systolic BP (F (2, 61)=3.86, p=0.03) demonstrated significantly greater responses to back massage. Conclusions Back massage significantly reduced anxiety in the study population. Systolic BP decreased to a greater degree in the male participants, particularly in those with severe heart failure and greater levels of anxiety and higher systolic BP. This study was conducted without a control group. Randomized clinical trials are needed to validate the effectiveness of back massage on patients with CHF. PMID:23186129

Effect of back massage intervention on anxiety, comfort, and physiologic responses in patients with congestive heart failure.

PubMed

Chen, Wei-Ling; Liu, Gin-Jen; Yeh, Shu-Hui; Chiang, Ming-Chu; Fu, Mao-Young; Hsieh, Yuan-Kai

2013-05-01

Patients suffering from congestive heart failure (CHF) frequently feel physical suffering and anxiety. The researchers investigated whether back massage could reduce anxiety, discomfort, and physical suffering in patients with CHF. The effects of gender and severity-dependent response of back massage on anxiety and discomfort in patients were also analyzed. The study used a quasi-experimental design with one group pretest and posttest. Sixty-four participants were recruited in southern Taiwan. The modified State Anxiety Inventory, the discomfort Visual Analogue Scale, electronic blood pressure (BP) gauges, stethoscopes and the pulse oximetry were used in this study. The participants' systolic BP (F (3, 189)=18.91, p<0.01), diastolic BP (F (3, 189)=13.40, p<0.01), heart rate (F (3, 189)=26.28, p<0.01), and respiratory rates (F (3, 189)=5.77, p<0.01) were significantly decreased after back massage. Oxygen saturation levels showed significant increases (F (3, 189)=42.82, p<0.01). Male participants revealed a more significant reduction in anxiety than the female participants (F (1, 50)=7.27, p=0.01). Those with more severe heart failure and greater levels of anxiety (F (2, 61)=4.31, p=0.02) and systolic BP (F (2, 61)=3.86, p=0.03) demonstrated significantly greater responses to back massage. Back massage significantly reduced anxiety in the study population. Systolic BP decreased to a greater degree in the male participants, particularly in those with severe heart failure and greater levels of anxiety and higher systolic BP. This study was conducted without a control group. Randomized clinical trials are needed to validate the effectiveness of back massage on patients with CHF.

Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania

PubMed Central

Tustin, Aaron W.; Hirsch, Annemarie G.; Rasmussen, Sara G.; Casey, Joan A.; Bandeen-Roche, Karen; Schwartz, Brian S.

2016-01-01

Background: Unconventional natural gas development (UNGD) produces environmental contaminants and psychosocial stressors. Despite these concerns, few studies have evaluated the health effects of UNGD. Objectives: We investigated associations between UNGD activity and symptoms in a cross-sectional study in Pennsylvania. Methods: We mailed a self-administered questionnaire to 23,700 adult patients of the Geisinger Clinic. Using standardized and validated questionnaire items, we identified respondents with chronic rhinosinusitis (CRS), migraine headache, and fatigue symptoms. We created a summary UNGD activity metric that incorporated well phase, location, total depth, daily gas production and inverse distance–squared to patient residences. We used logistic regression, weighted for sampling and response rates, to assess associations between quartiles of UNGD activity and outcomes, both alone and in combination. Results: The response rate was 33%. Of 7,785 study participants, 1,850 (24%) had current CRS symptoms, 1,765 (23%) had migraine headache, and 1,930 (25%) had higher levels of fatigue. Among individuals who met criteria for two or more outcomes, adjusted odds ratios for the highest quartile of UNGD activity compared with the lowest were [OR (95% CI)] 1.49 (0.78, 2.85) for CRS plus migraine, 1.88 (1.08, 3.25) for CRS plus fatigue, 1.95 (1.18, 3.21) for migraine plus fatigue, and 1.84 (1.08, 3.14) for all three outcomes together. Significant associations were also present in some models of single outcomes. Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281 PMID:27561132

Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania.

PubMed

Tustin, Aaron W; Hirsch, Annemarie G; Rasmussen, Sara G; Casey, Joan A; Bandeen-Roche, Karen; Schwartz, Brian S

2017-02-01

Unconventional natural gas development (UNGD) produces environmental contaminants and psychosocial stressors. Despite these concerns, few studies have evaluated the health effects of UNGD. We investigated associations between UNGD activity and symptoms in a cross-sectional study in Pennsylvania. We mailed a self-administered questionnaire to 23,700 adult patients of the Geisinger Clinic. Using standardized and validated questionnaire items, we identified respondents with chronic rhinosinusitis (CRS), migraine headache, and fatigue symptoms. We created a summary UNGD activity metric that incorporated well phase, location, total depth, daily gas production and inverse distance-squared to patient residences. We used logistic regression, weighted for sampling and response rates, to assess associations between quartiles of UNGD activity and outcomes, both alone and in combination. The response rate was 33%. Of 7,785 study participants, 1,850 (24%) had current CRS symptoms, 1,765 (23%) had migraine headache, and 1,930 (25%) had higher levels of fatigue. Among individuals who met criteria for two or more outcomes, adjusted odds ratios for the highest quartile of UNGD activity compared with the lowest were [OR (95% CI)] 1.49 (0.78, 2.85) for CRS plus migraine, 1.88 (1.08, 3.25) for CRS plus fatigue, 1.95 (1.18, 3.21) for migraine plus fatigue, and 1.84 (1.08, 3.14) for all three outcomes together. Significant associations were also present in some models of single outcomes. This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189-197; http://dx.doi.org/10.1289/EHP281.

United States Army Officer Development And Procurement During World War I and II: How The Army Grew Its Officer Corps

DTIC Science & Technology

2016-05-26

the United States wanted no part of it. Even after a German U-boat sank the Lusitania in 1915, President Woodrow Wilson won re-election with a slogan...of the Lusitania by a German U-boat on May 7, 1915 sent a shock through the world. The attack killed 1,189 passengers, including 124 Americans. This

Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics.

PubMed

Zhou, Mingliang; Xie, Longxiang; Yang, Zhaozhen; Zhou, Jiahai; Xie, Jianping

2017-04-01

Lysine succinylation (Ksucc) is a newly identified protein posttranslational modification (PTM), which may play an important role in cellular physiology. However, the role of lysine succinylation in antibiotic resistance remains elusive. Isocitrate lyase (ICL) is crucial for broad-spectrum antibiotics tolerance in Mycobacterium tuberculosis (Mtb). We previously found that MtbICL (Rv0467) has at least three succinylated lysine residues, namely K189, K322, and K334.To explore the effect of succinylation on the activity of MtbICL, mutants' mimicry of the lysine succinylation were generated by site-directed mutagenesis. ICL-K189E mutant strain is more sensitive than the wild-type to rifampicin and streptomycin, but not isoniazid. For the in vitro activity of the purified isocitrate lyase, only K189E mutant showed significantly decreased activity. Crystal structure analysis showed that Lys189 Glu dramatically increased the pKa of Glu188 and decreased the pKa of Lys190, whereas had negligible effect on other residues within 5 Å as well as disruption of the electrostatic interaction between Lys189 and Glu182, which might prevent the closure of the active site loop and cause severe reduction of the enzyme activity. Considering the genetic, biochemical, and crystallographical evidences together, the succinylation of specific ICL residue can fine-tune the bacterial resistance to selected antibiotics. The decreased enzymatic activity resulting from the succinylation-changed electrostatic interaction might underlie this phenotype. This study provided the first insight into the link between lysine succinylation and antibiotic resistance.

Hypophosphataemia at a large academic hospital in South Africa.

PubMed

Hoffmann, M; Zemlin, A E; Meyer, W P; Erasmus, R T

2008-10-01

The aim of this study was to determine the most common causes of hypophosphataemia (

Department of Agriculture Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... Import Restrictions on Certain 0579-AC74 Live Fish 189 Scrapie in Sheep and Goats 0579-AC92 190 Plant..., Farming Experience as an Eligibility Requirement; 5201, Eligibility of Equine Farmers and Ranchers for... Phone: 301 734-8695 RIN: 0579-AC74 189. SCRAPIE IN SHEEP AND GOATS Legal Authority: 7 USC 8301 to 8317...

Simultaneous LOFAR and AMI-LA observations of MAXI J1820+070

NASA Astrophysics Data System (ADS)

Broderick, Jess; Bright, Joe; Russell, Thomas; Rowlinson, Antonia; Fender, Rob; Done, Chris

2018-05-01

We report on the detection of MAXI J1820+070 (e.g. ATel #11399, #11418, #11420) with the Low-Frequency Array (LOFAR). Observations in the high band (115-189 MHz) were carried out from 2018 April 27 02:32:33.0-04:32:33.0 UTC (MJD 58235.106-58235.189).

47 CFR 87.189 - Requirements for public correspondence equipment and operations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AVIATION SERVICES Aircraft Stations § 87.189 Requirements for... continuous watch must be maintained on the frequencies used for safety and regularity of flight while public... interfere with message pertaining to safety of life and property or regularity of flight, or when ordered by...

Pilot Research Summaries, 1967-1970.

ERIC Educational Resources Information Center

Casey, James L.; Hayes, Larry K.

This report contains one-page summaries of a majority of the 134 research studies funded through the Oklahoma Consortium on Research Development. The research covers the whole spectrum of academic topics , from nursing to ecology to art to politics.. Brief summaries of a majority of the 37 development seminars funded through the Consortium are…

Women in surgery: a survey in Switzerland.

PubMed

Kaderli, Reto; Guller, Ulrich; Muff, Brigitte; Stefenelli, Ulrich; Businger, Adrian

2010-11-01

An increasing proportion of women work in medicine; however, only few choose surgical specialties. The objective of this study was to analyze the current situation of female surgeons and surgical residents in Switzerland concerning their personal and professional fulfillment. Of 318 female surgeons and surgical residents included in our study, 189 (59.4%) returned the anonymous questionnaire. Mentor-mentee relationships were mentioned by 110 (58.2%) of the 189 respondents. On the basis of a 7-point Likert scale, these women responded that they were moderately satisfied with their professional (mean score [SD], 2.7 [1.3]) and personal (mean score [SD], 3.0 [1.7]) lives. Of the 189 respondents, 113 (59.8%) mentioned that they felt underappreciated. The most important ways suggested for increasing the attractiveness of a surgical career for women were a reduction in workload (49 respondents [25.9%]), more flexible working hours (38 respondents [20.1%]), and better structured residency programs (23 respondents [12.2%]).

49 CFR 572.186 - Abdomen assembly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... part of the dummy assembly shown in drawing 175-0000 including load sensors specified in § 572.189(e... measuring sensor in the abdomen as shown in Figure U5; (5) The impactor impacts the dummy's abdomen at 4.0 m... of the forces of the three abdominal load sensors, specified in 572.189(e), shall be not less than...

A Comparison of Psychotomimetic Drug Effects on Rat Brain Norepinephrine Metabolism

DTIC Science & Technology

1973-02-19

189, No. I Copyright a 1974 by The Williams & Wilkins Co. inted in U.S.A. 7:’... .. .A K. (PA COMPARISON OF PSYCHOTOMIMETIC,_RUG EFFECTS ON...GOLDSTEIN, WILLIAM BOGGAN AND DANIEL X. FREEDMAN: A comparison of psychotomimetic drug effects on rat brain norepinephrine metabolism. J. Pharmacol. Exp...Thor. 189: 42-50,1974. V The effects of LSD, psilocybin, mescaline, amphetamine and cold water swimming stress on the metabolism of ’H-norepinephrine

The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens.

PubMed

Holdsworth, R; Hurley, C K; Marsh, S G E; Lau, M; Noreen, H J; Kempenich, J H; Setterholm, M; Maiers, M

2009-02-01

The 2008 report of the human leukocyte antigen (HLA) data dictionary presents serologic equivalents of HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, and -DQB1 alleles. The dictionary is an update of the one published in 2004. The data summarize equivalents obtained by the World Health Organization Nomenclature Committee for Factors of the HLA System, the International Cell Exchange, UCLA, the National Marrow Donor Program, recent publications, and individual laboratories. The 2008 edition includes information on 832 new alleles (685 class I and 147 class II) and updated information on 766 previously listed alleles (577 class I and 189 class II). The tables list the alleles with remarks on the serologic patterns and the equivalents. The serological equivalents are listed as expert assigned types, and the data are useful for identifying potential stem cell donors who were typed by either serology or DNA-based methods. The tables with HLA equivalents are available as a searchable form on the IMGT/HLA database Web site (http://www.ebi.ac.uk/imgt/hla/dictionary.html).

Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189

PubMed Central

McAfee, Samuel S.; Guley, Natalie M.; Del Mar, Nobel; Bu, Wei; Heldt, Scott A.; Honig, Marcia G.; Moore, Bob M.

2017-01-01

Abstract Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model. We evaluated mPFC, hippocampus CA1, and primary somatosensory/visual cortical areas (S1/V1). Although mTBI did not alter the power of oscillations, it did cause increased coherence of θ (4-10 Hz) and β (10-30 Hz) oscillations within mPFC and S1/V1, reduced CA1 sharp-wave ripple (SWR)-evoked LFP activity in mPFC, downshifted SWR frequencies in CA1, and enhanced θ-γ phase-amplitude coupling (PAC) within mPFC. These abnormalities might be linked to the impaired memory, depression, and persevering fear seen after mTBI. Treatment with the cannabinoid type-2 (CB2) receptor inverse agonist SMM-189 has been shown to mitigate functional deficits and neuronal injury after mTBI in mice. We found that SMM-189 also reversed most of the observed neurophysiological abnormalities. This neurophysiological rescue is likely to stem from the previously reported reduction in neuron loss and/or the preservation of neuronal function and connectivity resulting from SMM-189 treatment, which appears to stem from the biasing of microglia from the proinflammatory M1 state to the prohealing M2 state by SMM-189. PMID:28828401

Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189.

PubMed

Liu, Yu; McAfee, Samuel S; Guley, Natalie M; Del Mar, Nobel; Bu, Wei; Heldt, Scott A; Honig, Marcia G; Moore, Bob M; Reiner, Anton; Heck, Detlef H

2017-01-01

Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model. We evaluated mPFC, hippocampus CA1, and primary somatosensory/visual cortical areas (S1/V1). Although mTBI did not alter the power of oscillations, it did cause increased coherence of θ (4-10 Hz) and β (10-30 Hz) oscillations within mPFC and S1/V1, reduced CA1 sharp-wave ripple (SWR)-evoked LFP activity in mPFC, downshifted SWR frequencies in CA1, and enhanced θ-γ phase-amplitude coupling (PAC) within mPFC. These abnormalities might be linked to the impaired memory, depression, and persevering fear seen after mTBI. Treatment with the cannabinoid type-2 (CB2) receptor inverse agonist SMM-189 has been shown to mitigate functional deficits and neuronal injury after mTBI in mice. We found that SMM-189 also reversed most of the observed neurophysiological abnormalities. This neurophysiological rescue is likely to stem from the previously reported reduction in neuron loss and/or the preservation of neuronal function and connectivity resulting from SMM-189 treatment, which appears to stem from the biasing of microglia from the proinflammatory M1 state to the prohealing M2 state by SMM-189.

Towards a Definition for Health Care–Associated Infection

PubMed Central

Friedman, N Deborah; Levit, Dana; Taleb, Eyal; Marcus, Gil; Michaeli, Leah; Broide, Mor; Mengesha, Bethlehem; Zaidenstein, Ronit; Lazarovitch, Tsilia; Dadon, Mor; Kaye, Keith S; Marchaim, Dror

2018-01-01

Abstract Background Health care–associated infection (HcAI) is a term frequently used to describe community-onset infections likely to be caused by multidrug-resistant organisms (MDROs). The most frequently used definition was developed at Duke University Medical Center in 2002 (Duke-2002). Although some professional societies have based management recommendations on Duke-2002 (or modifications thereof), neither Duke-2002 nor other variations have had their performance measured. Methods A case–control study was conducted at Assaf Harofeh Medical Center (AHMC) of consecutive adult bloodstream infections (BSIs). A multivariable model was used to develop a prediction score for HcAI, measured by the presence of MDRO infection on admission. The performances of this new score and previously developed definitions at predicting MDRO infection on admission were measured. Results Of the 504 BSI patients enrolled, 315 had a BSI on admission and 189 had a nosocomial BSI. Patients with MDRO-BSI on admission (n = 100) resembled patients with nosocomial infections (n = 189) in terms of epidemiological characteristics, illness acuity, and outcomes more than patients with non-MDRO-BSI on admission (n = 215). The performances of both the newly developed score and the Duke-2002 definition to predict MDRO infection on admission were suboptimal (area under the receiver operating characteric curve, 0.76 and 0.68, respectively). Conclusions Although the term HcAI is frequently used, its definition does not perform well at predicting MDRO infection present on admission to the hospital. A validated score that calculates the risk of MDRO infection on admission is still needed to guide daily practice and improve patient outcomes.

A hospital discharge summary quality improvement program featuring individual and team-based feedback and academic detailing.

PubMed

Axon, Robert N; Penney, Fletcher T; Kyle, Thomas R; Zapka, Jane; Marsden, Justin; Zhao, Yumin; Mauldin, Patrick D; Moran, William P

2014-06-01

Discharge summaries are an important component of hospital care transitions typically completed by interns in teaching hospitals. However, these documents are often not completed in a timely fashion or do not include pertinent details of hospitalization. This report outlines the development and impact of a curriculum intervention to improve the quality of discharge summaries by interns and residents in Internal Medicine. A previous study demonstrated that a discharge summary curriculum featuring individualized feedback was associated with improved summary quality, but few subsequent studies have described implementation of similar curricula. No information exists on the utility of other strategies such as team-based feedback or academic detailing. Study participants were 96 Internal Medicine intern and resident physicians at an academic medical center-based training program. A comprehensive evidence-based discharge summary quality improvement program was developed and implemented that featured a discharge summary template to facilitate summary preparation, individual feedback, team-based feedback, academic detailing and an objective discharge summary evaluation instrument. The discharge summary evaluation instrument had moderate interrater reliability (κ = 0.72). Discharge summary scores improved from mean score of 70% to 82% (P = 0.05). Interns and residents participating in this program also reported increased confidence in producing and critiquing summaries. A comprehensive discharge summary curriculum can be feasibly implemented within the context of a residency program. Team-based feedback and academic detailing may serve to reinforce individual feedback and extend program reach.

Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure.

PubMed

Pudney, Christopher R; McGrory, Tom; Lafite, Pierre; Pang, Jiayun; Hay, Sam; Leys, David; Sutcliffe, Michael J; Scrutton, Nigel S

2009-05-25

Mutation of an active-site residue in morphinone reductase leads to a conformationally rich landscape that enhances the rate of hydride transfer from NADH to FMN at standard pressure (1 bar). Increasing the pressure causes interconversion between different conformational substates in the mutant enzyme. While high pressure reduces the donor-acceptor distance in the wild-type enzyme, increased conformational freedom "dampens" its effect in the mutant.We show that hydride transfer from NADH to FMN catalysed by the N189A mutant of morphinone reductase occurs along parallel "chemical" pathways in a conformationally rich free-energy landscape. We have developed experimental kinetic and spectroscopic tools by using hydrostatic pressure to explore this free-energy landscape. The crystal structure of the N189A mutant enzyme in complex with the unreactive coenzyme analogue NADH(4) indicates that the nicotinamide moiety of the analogue is conformationally less restrained than the corresponding structure of the wild-type NADH(4) complex. This increased degree of conformational freedom in the N189A enzyme gives rise to the concept of multiple reactive configurations (MRCs), and we show that the relative population of these states across the free-energy landscape can be perturbed experimentally as a function of pressure. Specifically, the amplitudes of individual kinetic phases that were observed in stopped-flow studies of the hydride transfer reaction are sensitive to pressure; this indicates that pressure drives an altered distribution across the energy landscape. We show by absorbance spectroscopy that the loss of charge-transfer character of the enzyme-coenzyme complex is attributed to the altered population of MRCs on the landscape. The existence of a conformationally rich landscape in the N189A mutant is supported by molecular dynamics simulations at low and high pressure. The work provides firm experimental and computational support for the existence of parallel pathways arising from multiple conformational states of the enzyme-coenzyme complex. Hydrostatic pressure is a powerful and general probe of multidimensional energy landscapes that can be used to analyse experimentally parallel pathways for enzyme-catalysed reactions. We suggest that this is especially the case following directed mutation of a protein, which can lead to increased population of reactant states that are essentially inaccessible in the free-energy landscape of wild-type enzyme.

Baseline Serum Clinical Chemistry Values in African Green Monkeys Before and After Sulfur Mustard

DTIC Science & Technology

2007-05-01

aspartate transaminase (189 %), blood urea nitrogen (75 %), creatine kinase (721 %), and lactate dehydrogenase (114 %) one day after HD exposure...ALT, 93 %), aspartate transaminase (AST, 189 %), blood urea nitrogen (BUN, 75 %), creatine kinase (CK, 721 %), and lactate dehydrogenase (LDH, 114...alkaline phosphate (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), calcium (Ca2+), creatine kinase (CK

Corrigendum to ;Numerical dissipation control in high order shock-capturing schemes for LES of low speed flows; [J. Comput. Phys. 307 (2016) 189-202

NASA Astrophysics Data System (ADS)

Kotov, D. V.; Yee, H. C.; Wray, A. A.; Sjögreen, Björn; Kritsuk, A. G.

2018-01-01

The authors regret for the typographic errors that were made in equation (4) and missing phrase after equation (4) in the article "Numerical dissipation control in high order shock-capturing schemes for LES of low speed flows" [J. Comput. Phys. 307 (2016) 189-202].

Research Program in Tropical Infectious Diseases

DTIC Science & Technology

1992-12-01

Individ- patiis B and delta in the southeast of Chiapas , Mexico . uals~~~~~~~~~~~~~ inetdwt B h r oiiefrHeuae Aivosdelrimstigdcon Medica ( Mexico ). 20, 189...patterns of drug resistance of Neisseria gonorrhea in various regions . 4. Determine patterns of malaria transmission; maintain surveillance for chloroquine...remote sensing models developed for use in predicting temporal and spatial changes in malaria vector abundance in Mexico , in a second ecologically

Experiments in Developing Wakes

DTIC Science & Technology

2014-04-27

uncorrected and the right is corrected. The top row plots Mrms and the bottom row Wrms. All axis scales are the same. The measurements in a...water (dashed). Timesteps are M= 0, 0.52, 1.03, 1.89. The top row plots Mrms and the bottom row Wrm*. The uncertainty in velocity profile...reconstructions, which ought to be uniform vertically, is about 10% of the peak disturbance quantity. The profile from pure water does not differ

Current Effects of Army Materiel Command Operation Order 16 189 at TACOM LCMC

DTIC Science & Technology

2017-05-25

Alexandria, VA: CNA Corporation. 78 Creswell, J. W. (2015). Educational Research: Planning, Conducting, and Evaluating Quantitative and Qualitative...research and development that relate to military requirements and test and evaluation . (d)(3) The Secretary shall establish or designate a single office or...for research. 4. Collect data. 5. Analyze and interpret the data. 42 6. Report and evaluate the research. Step 4 of the research process is

Accelerator Production and Separations for High Specific Activity Rhenium-186

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jurisson, Silvia S.; Wilbur, D. Scott

2016-04-01

Tungsten and osmium targets were evaluated for the production of high specific activity rhenium-186. Rhenium-186 has potential applications in radiotherapy for the treatment of a variety of diseases, including targeting with monoclonal antibodies and peptides. Methods were evaluated using tungsten metal, tungsten dioxide, tungsten disulfide and osmium disulfide. Separation of the rhenium-186 produced and recycling of the enriched tungsten-186 and osmium-189 enriched targets were developed.

Anti-inflammatory activity of cannabinoid receptor 2 ligands in primary hPDL fibroblasts.

PubMed

Abidi, Ammaar H; Presley, Chaela S; Dabbous, Mustafa; Tipton, David A; Mustafa, Suni M; Moore, Bob M

2018-03-01

Approximately 65 million adults in the US have periodontitis, causing tooth loss and decreased quality of life. Cannabinoids modulate immune responses, and endocannabinoids are prevalent during oral cavity inflammation. Targets for intervention in periodontal inflammation are cannabinoid type 1 and 2 receptors (CB1R, CB2R), particularly CB2R because its levels increase during inflammation. We previously demonstrated that SMM-189 (CB2R inverse agonist) decreased pro-inflammatory cytokine production in primary microglial cells. The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-α, or IL-1β. Cytotoxic effects of cannabinoid compounds (10 -4 -10 -6.5  M), LPS (1-1000 ng/ml), TNFα (10 ng/ml) and IL-1β (1 ng/ml) were assessed by measuring effects on cellular dehydrogenase activity. IL-6 and MCP-1 production were measured using Mesoscale Discovery (MSD) Human Pro-Inflammatory IL-6 and MSD Human Chemokine MCP-1 kits and analyzed using MSD Sector 2400 machine. EC 50 values for AEA, SMM-189, and HU-308 were 16 μM, 13 μM, and 7.3 μM respectively. LPS (1 μg/ml), TNF-α (10 ng/ml), and IL-1β (1 ng/ml) increased IL-6 and MCP-1 production, which were inhibited by AEA, SMM-189, and HU-308. AEA alone significantly increased IL-6, but not MCP-1 levels, but the other cannabinoids alone had no effect. The effective inhibition of LPS, TNF-α, IL-1β stimulated IL-6 and MCP-1 production by CB2R ligands in hPDLFs suggests that targeting the endocannabinoid system may lead to development of novel drugs for periodontal therapy, aiding strategies to improve oral health. Copyright © 2017 Elsevier Ltd. All rights reserved.

12 CFR 1805.101 - Summary.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Summary. 1805.101 Section 1805.101 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM General Provisions § 1805.101 Summary. Under the Community...

Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.

PubMed Central

Kinsella, B T; Erdman, R A; Maltese, W A

1991-01-01

ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e., Cys-Ali-Ali-Ser/Met (where Ali represents an aliphatic residue). In other low molecular mass GTP-binding proteins, cysteines are modified by 20-carbon geranylgeranyl groups within a Cys-Ali-Ali-Leu motif. We changed the terminal Ser-189 of Ha-ras p21 to Leu-189 by site-directed mutagenesis and found that the protein was modified by [3H]geranylgeranyl instead of [3H]farnesyl in an in vitro assay. Gel-permeation chromatography of [3H]mevalonate-labeled hydrocarbons released from immunoprecipitated ras proteins overexpressed in COS cells indicated that Ha-ras p21(Leu-189) was also a substrate for 20-carbon isoprenyl modification in vivo. Additional steps in Ha-ras p21 processing, normally initiated by farnesylation, appear to be supported by geranylgeranylation, based on metabolic labeling of Ha-ras p21(Leu-189) with [3H]palmitate and its subcellular localization in a particulate fraction from COS cells. These observations indicate that the amino acid occupying the terminal position (Xaa) in the Cys-Ali-Ali-Xaa motif constitutes a key structural feature by which Ha-ras p21 and other proteins with ras-like COOH-terminal isoprenylation sites are distinguished as substrates for farnesyl- or geranylgeranyltransferases. Images PMID:1924354

Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kinsella, B.T.; Erdman, R.A.; Maltese, W.A.

ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e., Cys-Ali-Ali-Ser/Met (where Ali represents an aliphatic residue). In other low molecular mass GTP-binding proteins, cysteines are modified by 20-carbon geranylgeranyl groups within a Cys-Ali-Ali-Leu motif. The authors changed the terminal Ser-189 of Ha-ras p21 to Leu-189 by site-directed mutagenesis and found that the protein was modified by ({sup 3}H)geranylgeranyl instead of ({sup 3}H)farnesyl in an in vitro assay. Gel-permeation chromatography of ({sup 3}H)mevalonate-labeled hydrocarbons released from immunoprecipitated ras proteins overexpressed in COS cells indicated that Ha-ras p21 (Leu-189) wasmore » also a substrate for 20-carbon isoprenyl modification in vivo. Additional steps in Ha-ras p21 processing, normally initiated by farnesylation, appear to be supported by geranylgeranylation, based on metabolic labeling of Ha-ras p21 (Leu-189) with ({sup 3}H) palmitate and its subcellular localization in a particulate fraction from COS cells. These observations indicate that the amino acid occupying the terminal position (Xaa) in the Cys-Ali-Ali-Xaa motif constitutes a key structural feature by which Ha-ras p21 and other proteins with ras-like COOH-terminal isoprenylation sites are distinguished as substrates for farnesyl- or geranylgeranyltransferases.« less

Overgeneral autobiographical memory effect in older depressed adults.

PubMed

Ricarte, Jorge J; Latorre, José M; Ros, Laura; Navarro, Beatriz; Aguilar, María J; Serrano, Juan Pedro

2011-11-01

This research aims to investigate the characteristics of autobiographical retrieval in a group of older depressed adults compared with a control group of the same age. The sample was recruited from local primary care services. All participants were administered a demographic questionnaire and completed the Mini-Mental State Examination (MMSE; Lobo, A., Ezquerra, J., Gómez-Burgada, F., Sala, J.M., & Seva-Díaz, A. (1979). El Mini-Examen Cognoscitivo: Un test sencillo y práctico para detectar alteraciones intelectuales en pacientes médicos. Actas Luso-Españolas de Neurología, Psiquiatría y Ciencia, 3, 189-202), the Life Satisfaction Index (LSI; Stock, W., Okun, M., & Gómez, J. (1994). Subjective well-being measures: Reliability and validity among Spanish elders. International Journal of Aging and Human Development, 38, 221-235), and the Beck Hopelessness Scale (BHS; Beck, A.T., Weissman, A., Lester, D., & Trexler, L. (1974). The measurement of pessimism: The hopelessness scale. Journal of Consulting and Clinical Psychology, 42, 861-865). Finally, all participants completed the Autobiographical Memory Test (AMT; Williams, J.M.G., & Broadbent, K. (1986). Autobiographical memory in suicide attempters. Journal of Abnormal Psychology, 95, 144-149). Older adults with depression were less specific in their memories than the controls. Higher categoric retrieval for negative cue words compared with positive cue words was only found for older adults with depression. Specific retrieval in the group without depression was positively related to Life Satisfaction and negatively to hopelessness. The overgeneral effect appeared for older adults with depression due to the higher presence of extended memories (events lasting for more than 24 h) rather than categoric retrievals (summary of repeated events). The strong correlation between specific memories and Life Satisfaction among non-depressed older adults suggests its potential role as a protective factor for depression.

Phase I of the Near Term Hybrid Passenger Vehicle Development Program. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-10-01

The results of Phase I of the Near-Term Hybrid Vehicle Program are summarized. This phase of the program ws a study leading to the preliminary design of a 5-passenger hybrid vehicle utilizing two energy sources (electricity and gasoline/diesel fuel) to minimize petroleum usage on a fleet basis. This report presents the following: overall summary of the Phase I activity; summary of the individual tasks; summary of the hybrid vehicle design; summary of the alternative design options; summary of the computer simulations; summary of the economic analysis; summary of the maintenance and reliability considerations; summary of the design for crash safety;more » and bibliography.« less

DIVISION OF ISOTOPES DEVELOPMENT RESEARCH AND DEVELOPMENT PROJECTS: 1968. Progress Reports on Sponsored Work.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1969-01-01

This is the second edition of the Division of Isotopes Development project summaries. It presents a short summary of objectives, results, and future plans for each research or development project sponsored by the Division within each of eight program areas.

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Priestley, E. Scott; De Lucca, Indawati; Zhou, Jinglan

A 6-amidinotetrahydroquinoline screening hit was driven to a structurally novel, potent, and selective FVIIa inhibitor through a combination of library synthesis and rational design. An efficient gram-scale synthesis of the active enantiomer BMS-593214 was developed, which required significant optimization of the key Povarov annulation. Importantly, BMS-593214 showed antithrombotic efficacy in a rabbit arterial thrombosis model. A crystal structure of BMS-593214 bound to FVIIa highlights key contacts with Asp 189, Lys 192, and the S2 pocket.

75 FR 54806 - Approval and Promulgation of Implementation Plans-Maricopa County (Phoenix) PM-10 Nonattainment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... program is codified in ARS 49-457 and Arizona Administrative Code (AsAC) R18-2-610 and R18-2-611. ARS 49... proposing to fully approve the amendment to ARS-457 which was submitted with the 189(d) plan, we do not... registered with the control officer. These measures are implemented through ARS 49-474.05. See 189(d) plan...

Automatic and user-centric approaches to video summary evaluation

NASA Astrophysics Data System (ADS)

Taskiran, Cuneyt M.; Bentley, Frank

2007-01-01

Automatic video summarization has become an active research topic in content-based video processing. However, not much emphasis has been placed on developing rigorous summary evaluation methods and developing summarization systems based on a clear understanding of user needs, obtained through user centered design. In this paper we address these two topics and propose an automatic video summary evaluation algorithm adapted from teh text summarization domain.

Development of Fiber Reinforced Track Pad Materials

DTIC Science & Technology

1986-04-01

Transfer and Vulcanization of Rubber , I.R.I. Monograph, Elsevier, 1971. 12 Bergstrom, E.W., " Wear Resistant Rubber Tank Track Pads," Rock Island Arsenal...Fracture Mechanics to Rubber Articles, Including Tyres ," Phil. Trans. R. Soc. Lond. A299,,189-202 (1981). 10 Gent, Fielding-Russell, Livingston, and...System for Rubber Bonded to Brass-Plated Steel Tyre Cord," NR Technology, vol 11, Part 2, 1980, pp 21-27. 16 Lindley, P.B., Engineering Design with

Development of a Cancer Care Summary Through the Electronic Health Record.

PubMed

Carr, Laurie L; Zelarney, Pearlanne; Meadows, Sarah; Kern, Jeffrey A; Long, M Bronwyn; Kern, Elizabeth

2016-02-01

Our objective was to improve communication concerning lung cancer patients by developing and distributing a Cancer Care Summary that would provide clinically useful information about the patient's diagnosis and care to providers in diverse settings. We designed structured, electronic forms for the electronic health record (EHR), detailing tumor staging, classification, and treatment. To ensure completeness and accuracy of the information, we implemented a data quality cycle, composed of reports that are reviewed by oncology clinicians. The data from the EHR forms are extracted into a structured query language database system on a daily basis, from which the Summaries are derived. We conducted focus groups regarding the utility, format, and content of the Summary. Cancer Care Summaries are automatically generated 4 months after a patient's date of diagnosis, then every 6 months for those receiving treatment, and on an as-needed basis for urgent care or hospital admission. The product of our improvement project is the Cancer Care Summary. To date, 102 individual patient Summaries have been generated. These documents are automatically entered into the National Jewish Health (NJH) EHR, attached to correspondence to primary care providers, available to patients as electronic documents on the NJH patient portal, and faxed to emergency departments and admitting physicians on patient evaluation. We developed a sustainable tool to improve cancer care communication. The Cancer Care Summary integrates information from the EHR in a timely manner and distributes the information through multiple avenues. Copyright © 2016 by American Society of Clinical Oncology.

TEN-YEAR FOLLOW UP OF A PHASE II STUDY OF DOSE-INTENSE PACLITAXEL WITH CISPLATIN AND CYCLOPHOSPHAMIDE AS INITIAL THERAPY FOR POOR-PROGNOSIS ADVANCED-STAGE EPITHELIAL OVARIAN CANCER

PubMed Central

Sarosy, Gisele A.; Hussain, Mahrukh M.; Seiden, Michael V.; Fuller, A.F.; Nikrui, N.; Goodman, Annekathryn; Minasian, Lori; Reed, Eddie; Steinberg, Seth M.; Kohn, Elise C.

2009-01-01

SUMMARY Background To assess activity and toxicity in newly diagnosed advanced stage epithelial ovarian cancer (EOC) patients receiving dose-intense paclitaxel, cyclophosphamide, cisplatin, and filgrastim delivered with a flexible dosing schedule. Methods Patients with Stage III/IV EOC received cyclophosphamide 750 mg/m2, followed by 24 hr infusion of paclitaxel 250 mg/m2, and cisplatin 75 mg/m2 on day 2. Filgrastim began on day 3 at 10 μg/kg/d × 9d. Patients received six cycles of all drugs. Those with pathologic complete response or microscopic residual disease at the conclusion of six cycles of therapy received an additional cycles two to four cycles of paclitaxel with cyclophosphamide. Patients with objective response continued cyclophosphamide and paclitaxel. Results 62 patients were enrolled. Thirty-two of these 62 patients had stage IIIC disease, and 26 of 62 had stage IV disease. Using an intent to treat analysis, 55 (89%) experienced clinical complete remission (CCR). With a median potential follow-up of 11.4 years, the median progression free survival is 18.9 months and median survival is 5.4 years. The most serious toxicity was grade 3/4 neutropenic fever (35%). Although all participants developed peripheral neuropathy, improvement in neuropathic symptoms began with decrease or cessation of paclitaxel. Conclusions This regimen yielded a high response rate and encouraging overall survival. These data and those of the Japanese Gynecologic Oncology Group suggest that further study of dose dense or intense paclitaxel regimens in women with newly diagnosed advanced stage EOC is warranted. PMID:20091841

Large River Sediment Transport and Deposition: An Annotated Bibliography.

DTIC Science & Technology

1998-04-01

Guttenberg, Iowa, to Cairo, Illinois. Maps are developed by using 1:24,000 color infrared aerial photography flown in mid-August 1975. Aquatic, marsh...National Technical Information Service, Springfield, Virginia. Technical Report M-76-6. 56 pp. Sequential color- infrared aerial photos and corresponding...Journal of Waterways, Harbors, and Coastlines (Engineering Division) 102( WW2 ): 189-202. The Potamology Section of the U.S. Army Corps of Engineers

Summary of Development as a Reflective Practitioner

ERIC Educational Resources Information Center

Quan, Hong; Yang, Shihua; Chen, Honglin

2010-01-01

This paper is a summary which explores the effectiveness and evaluation of my development as a reflective practitioner. It focuses on development with two useful theories about learning and teaching. They are about deep learning & surface learning and levels of teaching. Actually, when I put these theories to practice reflectively, the result…

Reliability Modeling Development and Its Applications for Ceramic Capacitors with Base-Metal Electrodes (BMEs)

NASA Technical Reports Server (NTRS)

Liu, Donhang

2014-01-01

This presentation includes a summary of NEPP-funded deliverables for the Base-Metal Electrodes (BMEs) capacitor task, development of a general reliability model for BME capacitors, and a summary and future work.

Prenatal Treatment for Serious Neurological Sequelae of Congenital Toxoplasmosis: An Observational Prospective Cohort Study

PubMed Central

Cortina-Borja, Mario; Tan, Hooi Kuan; Wallon, Martine; Paul, Malgorzata; Prusa, Andrea; Buffolano, Wilma; Malm, Gunilla; Salt, Alison; Freeman, Katherine; Petersen, Eskild; Gilbert, Ruth E.

2010-01-01

Background The effectiveness of prenatal treatment to prevent serious neurological sequelae (SNSD) of congenital toxoplasmosis is not known. Methods and Findings Congenital toxoplasmosis was prospectively identified by universal prenatal or neonatal screening in 14 European centres and children were followed for a median of 4 years. We evaluated determinants of postnatal death or SNSD defined by one or more of functional neurological abnormalities, severe bilateral visual impairment, or pregnancy termination for confirmed congenital toxoplasmosis. Two-thirds of the cohort received prenatal treatment (189/293; 65%). 23/293 (8%) fetuses developed SNSD of which nine were pregnancy terminations. Prenatal treatment reduced the risk of SNSD. The odds ratio for prenatal treatment, adjusted for gestational age at maternal seroconversion, was 0.24 (95% Bayesian credible intervals 0.07–0.71). This effect was robust to most sensitivity analyses. The number of infected fetuses needed to be treated to prevent one case of SNSD was three (95% Bayesian credible intervals 2–15) after maternal seroconversion at 10 weeks, and 18 (9–75) at 30 weeks of gestation. Pyrimethamine-sulphonamide treatment did not reduce SNSD compared with spiramycin alone (adjusted odds ratio 0.78, 0.21–2.95). The proportion of live-born infants with intracranial lesions detected postnatally who developed SNSD was 31.0% (17.0%–38.1%). Conclusion The finding that prenatal treatment reduced the risk of SNSD in infected fetuses should be interpreted with caution because of the low number of SNSD cases and uncertainty about the timing of maternal seroconversion. As these are observational data, policy decisions about screening require further evidence from a randomized trial of prenatal screening and from cost-effectiveness analyses that take into account the incidence and prevalence of maternal infection. Please see later in the article for the Editors' Summary PMID:20967235

Demonstration of helicase activity in the nonstructural protein, NSs, of the negative-sense RNA virus, groundnut bud necrosis virus.

PubMed

Bhushan, Lokesh; Abraham, Ambily; Choudhury, Nirupam Roy; Rana, Vipin Singh; Mukherjee, Sunil Kumar; Savithri, Handanahal Subbarao

2015-04-01

The nonstructural protein NSs, encoded by the S RNA of groundnut bud necrosis virus (GBNV) (genus Tospovirus, family Bunyaviridae) has earlier been shown to possess nucleic-acid-stimulated NTPase and 5' α phosphatase activity. ATP hydrolysis is an essential function of a true helicase. Therefore, NSs was tested for DNA helicase activity. The results demonstrated that GBNV NSs possesses bidirectional DNA helicase activity. An alanine mutation in the Walker A motif (K189A rNSs) decreased DNA helicase activity substantially, whereas a mutation in the Walker B motif resulted in a marginal decrease in this activity. The parallel loss of the helicase and ATPase activity in the K189A mutant confirms that NSs acts as a non-canonical DNA helicase. Furthermore, both the wild-type and K189A NSs could function as RNA silencing suppressors, demonstrating that the suppressor activity of NSs is independent of its helicase or ATPase activity. This is the first report of a true helicase from a negative-sense RNA virus.

Pentahydroxyscirpene—Producing Strains, Formation In Planta, and Natural Occurrence

PubMed Central

Varga, Elisabeth; Wiesenberger, Gerlinde; Fruhmann, Philipp; Malachová, Alexandra; Svoboda, Thomas; Lemmens, Marc; Adam, Gerhard; Berthiller, Franz

2016-01-01

Trichothecenes are a class of structurally diverse mycotoxins with more than 200 naturally occurring compounds. Previously, a new compound, pentahydroxyscirpene (PHS), was reported as a byproduct of a nivalenol producing Fusarium strain, IFA189. PHS contains a hydroxy group at C-8 instead of the keto group of type B trichothecenes. In this work, we demonstrate that IFA189 belongs to the species Fusarium kyushuense using molecular tools. Production of PHS in vitro was also observed for several isolates of other Fusarium species producing nivalenol. Furthermore, we report the formation of 4-acetyl-PHS by F. kyushuense on inoculated rice. Wheat ears of the variety Remus were infected with IFA189 and the in planta production of PHS was confirmed. Natural occurrence of PHS was verified in barley samples from the Czech Republic using a liquid chromatographic-tandem mass spectrometric method validated for this purpose. Toxicity of PHS to wheat ribosomes was evaluated with a coupled in vitro transcription and translation assay, which showed that PHS inhibits protein biosynthesis slightly less than nivalenol and deoxynivalenol. PMID:27754401

Correlation, evaluation, and extension of linearized theories for tire motion and wheel shimmy

NASA Technical Reports Server (NTRS)

Smiley, Robert F

1957-01-01

An evaluation is made of the existing theories of a linearized tire motion and wheel shimmy. It is demonstrated that most of the previously published theories represent varying degrees of approximation to a summary theory developed in this report which is a minor modification of the basic theory of Von Schlippe and Dietrich. In most cases where strong differences exist between the previously published theories and summary theory, the previously published theories are shown to possess certain deficiencies. A series of systematic approximations to the summary theory is developed for the treatment of problems too simple to merit the use of the complete summary theory, and procedures are discussed for applying the summary theory and its systematic approximations to the shimmy of more complex landing-gear structures than have previously been considered. Comparisons of the existing experimental data with the predictions of the summary theory and the systematic approximations provide a fair substantiation of the more detailed approximate theories.

Summaries of Research - Fiscal Year 1983.

DTIC Science & Technology

1984-02-01

computerized dental emergency diagnosis and treatment programs in development at NDRI, has been determined. Portable electrically driven handpiece systems...AD-A140 259 SUMMARIES OF RESEARCH - FISCAL YEAR 1983U NAVAL DENTAL RESEARCH INST GREAT LAKES IL FEB 84U UC’AIE. NDRI-PR-84-01 UNCLASSIFIED F/G 6/5 NL...SUMMARIE-S OF RESEARCH FISCAL YEAR 1983 -CTE SAPR 19 1984 . A NAA.1 DENTAL RESEARCH INSTITUTE Naval Medical Research and Development Command 84 04 18

G189A analytical simulation of the RITE Integrated Waste Management-Water System

NASA Technical Reports Server (NTRS)

Coggi, J. V.; Clonts, S. E.

1974-01-01

This paper discusses the computer simulation of the Integrated Waste Management-Water System Using Radioisotopes for Thermal Energy (RITE) and applications of the simulation. Variations in the system temperature and flows due to particular operating conditions and variations in equipment heating loads imposed on the system were investigated with the computer program. The results were assessed from the standpoint of the computed dynamic characteristics of the system and the potential applications of the simulation to system development and vehicle integration.

Prevalence of Mycoplasma genitalium in different population groups: systematic review andmeta-analysis.

PubMed

Baumann, Lukas; Cina, Manuel; Egli-Gany, Dianne; Goutaki, Myrofora; Halbeisen, Florian S; Lohrer, Gian-Reto; Ali, Hammad; Scott, Pippa; Low, Nicola

2018-06-01

Mycoplasma genitalium is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of M. genitalium in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. We included studies with 500 participants or more. Two reviewers independently screened and selected studies and extracted data. We examined forest plots and conducted random-effects meta-analysis to estimate prevalence, if appropriate. Between-study heterogeneity was examined using the I 2 statistic and meta-regression. Of 3316 screened records, 63 were included. In randomly selected samples from the general population, the summary prevalence was 1.3% (95% CI 1.0% to 1.8%, I 2 41.5%, three studies, 9091 people) in countries with higher levels of development and 3.9% (95% CI 2.2 to 6.7, I 2 89.2%, three studies, 3809 people) in countries with lower levels. Prevalence was similar in women and men (P=0.47). In clinic based samples, prevalence estimates were higher, except in asymptomatic patients (0.8%, 95% CI 0.4 to 1.4, I 2 0.0%, three studies, 2889 people). Summary prevalence estimates were, in the following groups: pregnant women 0.9% (95% CI 0.6% to 1.4%, I 2 0%, four studies, 3472 people), MSM in the community 3.2% (95% CI 2.1 to 5.1, I 2 78.3%, five studies, 3012 people) and female CSWs in the community 15.9% (95% CI 13.5 to 18.9, I 2 79.9%, four studies, 4006 people). This systematic review can inform testing guidelines for M. genitalium . The low estimated prevalence of M. genitalium in the general population, pregnant women and asymptomatic attenders at clinics does not support expansion of testing to these groups. PROSPERO: CRD42015020420. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Work Disability Associated with Cancer Survivorship and Other Chronic Conditions

PubMed Central

Short, Pamela Farley; Vasey, Joseph J.; BeLue, Rhonda

2014-01-01

Summary The long-term effects of cancer and its treatment on employment and productivity are a major concern for the 40% of cancer survivors in the U.S. who are working age. This study’s objectives were (1) to quantify the increase in work disability attributable to cancer in a cohort of adult survivors who were an average of 46 months post-diagnosis and (2) to compare disability rates in cancer survivors to individuals with other chronic conditions. Data from the Penn State Cancer Survivor Study (PSCSS) and the Health and Retirement Study (HRS) were compared. The PSCSS sample included 647 survivors age 55–65, diagnosed at four medical centers in Pennsylvania and Maryland. There were 5988 similarly aged subjects without cancer in the HRS. Adjusted odds ratios for work disability were estimated for cancer survivorship, heart disease, stroke, diabetes, lung disease, and arthritis/rheumatism with multivariate logistic regression. Even for cancer-free survivors, the disability rate was significantly higher in comparison to adults with no chronic conditions (female OR=1.94; male OR=1.89). There were few significant differences between disability rates for cancer and other conditions. The elevated disability rate is another argument for viewing cancer survivorship as a chronic condition potentially requiring a broad range of psychosocial services. PMID:17429835

The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.

PubMed

Chen, Lihua; Liu, Min; Bao, Jing; Xia, Yunbao; Zhang, Jiuquan; Zhang, Lin; Huang, Xuequan; Wang, Jian

2013-01-01

To perform a meta-analysis exploring the correlation between the apparent diffusion coefficient (ADC) and tumor cellularity in patients. We searched medical and scientific literature databases for studies discussing the correlation between the ADC and tumor cellularity in patients. Only studies that were published in English or Chinese prior to November 2012 were considered for inclusion. Summary correlation coefficient (r) values were extracted from each study, and 95% confidence intervals (CIs) were calculated. Sensitivity and subgroup analyses were performed to investigate potential heterogeneity. Of 189 studies, 28 were included in the meta-analysis, comprising 729 patients. The pooled r for all studies was -0.57 (95% CI: -0.62, -0.52), indicating notable heterogeneity (P<0.001). After the sensitivity analysis, two studies were excluded, and the pooled r was -0.61 (95% CI: -0.66, -0.56) and was not significantly heterogeneous (P = 0.127). Regarding tumor type subgroup analysis, there were sufficient data to support a strong negative correlation between the ADC and cellularity for brain tumors. There was no notable evidence of publication bias. There is a strong negative correlation between the ADC and tumor cellularity in patients, particularly in the brain. However, larger, prospective studies are warranted to validate these findings in other cancer types.

Ciprofloxacin and Trimethoprim Cause Phage Induction and Virulence Modulation in Staphylococcus aureus

PubMed Central

Goerke, Christiane; Köller, Johanna; Wolz, Christiane

2006-01-01

In Staphylococcus aureus strains of human origin, phages which integrate into the chromosomal gene coding for β-hemolysin (hlb) are widely distributed. Most of them encode accessory virulence determinants such as staphylokinase (sak) or enterotoxins. Here, we analyzed the effects of ciprofloxacin and trimethoprim on phage induction and expression of phage-encoded virulence factors by using isolates from patients with cystic fibrosis for which the induction of hlb-converting phages was demonstrated in vivo (C. Goerke, S. Matias y Papenberg, S. Dasbach, K. Dietz, R. Ziebach, B. C. Kahl, and C. Wolz, J. Infect. Dis. 189:724-734, 2004) as well as a φ13 lysogen of phage-cured strain 8325-4. Treatment of lysogens with subinhibitory concentrations of either antibiotic resulted in (i) delysogenization of strains resembling the isolates picked up after chronic lung infection and (ii) replication of phages in the bacterial host in a dose-dependent manner. Ciprofloxacin treatment resulted in enhanced recA transcription, indicating involvement of the SOS response in phage mobilization. Induction of φ13 was linked to elevated expression of the phage-encoded virulence gene sak, chiefly due to the activation of latent phage promoters. In summary, we could show the induction of hlb-converting phages and a subsequent virulence modulation of the host bacterium by ciprofloxacin and trimethoprim. PMID:16377683

Beverage Consumption Patterns and Micronutrient and Caloric Intake from Beverages in Older Adults with Mild Cognitive Impairment.

PubMed

Venci, Brittany; Hodac, Nicole; Lee, Seung-Yeon; Shidler, Marcelle; Krikorian, Robert

2015-01-01

The purpose of this study was to determine total water intake and patterns of beverage consumption, and its contribution to total daily micronutrients and calories in older adults with mild memory decline. A descriptive, cross-sectional study was used with 60 independent community-dwelling older adults (71.7 ± 5.4 years) with mild cognitive impairment, who were mostly female, well-educated, and white. Three-day food records were analyzed using the Nutrition Data Systems for Research. Descriptive statistics were conducted for a summary of demographics, the average intakes of beverages, and the contribution of beverages to total calorie and micronutrient intakes. Total daily water intake was 53.6 ± 26.7 fl oz and milk, plain water, and tea/coffee were beverages consumed most frequently. Beverage consumption contributed substantially to the intake of vitamin D (29.4%), calcium (26.4%), riboflavin (22.0%), magnesium (18.9%), and vitamin C (18.1%), but constituted only ∼12.5% of total energy. These findings suggest that nutrient-dense beverages play a fundamental role in overall micronutrient intake, despite comprising a small component of daily caloric intake. Incorporating adequate amounts of such beverages in meals and snacks may help older adults meet their nutrient recommendations.

12 CFR 1805.101 - Summary.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM General Provisions § 1805.101 Summary. Under the Community Development Financial Institutions Program, the Fund will provide financial and technical assistance to...

12 CFR 1805.101 - Summary.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM General Provisions § 1805.101 Summary. Under the Community Development Financial Institutions Program, the Fund will provide financial and technical assistance to...

12 CFR 1805.101 - Summary.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM General Provisions § 1805.101 Summary. Under the Community Development Financial Institutions Program, the Fund will provide financial and technical assistance to...

12 CFR 1805.101 - Summary.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM General Provisions § 1805.101 Summary. Under the Community Development Financial Institutions Program, the Fund will provide financial and technical assistance to...

12 CFR 1806.101 - Summary.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Summary. 1806.101 Section 1806.101 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY BANK ENTERPRISE AWARD PROGRAM General Provisions § 1806.101 Summary. (a) Under the Bank Enterprise Award Program, the...

Comparison of PCR primer-based strategies for characterization of ammonia oxidizer communities in environmental samples.

PubMed

Mahmood, Shahid; Freitag, Thomas E; Prosser, James I

2006-06-01

PCR-based techniques are commonly used to characterize microbial communities, but are subject to bias that is difficult to assess. This study aimed to evaluate bias of several PCR primer-based strategies used to study diversity of autotrophic ammonia oxidizers. 16S rRNA genes from soil- or sediment-DNA were amplified using primers considered either selective or specific for betaproteobacterial ammonia oxidizers. Five approaches were assessed: (a) amplification with primers betaAMO143f-betaAMO1315r; (b) amplification with primers CTO189f-CTO654r; (c) nested amplification with betaAMO143f-betaAMO1315r followed by CTO189f-CTO654r primers; (d) nested amplification with betaAMO143f-betaAMO1315r and CTO189f-Pf1053r primers; (e) nested amplification with 27f-1492r and CTO189f-CTO654r primers. Amplification products were characterized by denaturing gradient gel electrophoresis (DGGE) analysis after further amplification with 357f-GC-518r primers. DGGE profiles of soil communities were heterogeneous and depended on the approach followed. Ammonia oxidizer diversity was higher using approaches (b), (c) and (e) than using (a) and (d), where sequences of the most prominent bands showed similarities to nonammonia oxidizers. Profiles from marine sediments were more consistent, regardless of the approach adopted, and sequence analysis of excised bands indicated that these consisted of ammonia oxidizers only. The study demonstrates the importance of choice of primer, of screening for sequences of nontarget organisms and use of several approaches when characterizing microbial communities in natural environments.

Fatigue Strength of Welded Joints and Fatigue Strength of Welded Joints: A Review of the Literature to July 1, 1936

DTIC Science & Technology

1936-12-02

a1loying. The first part of this statement Is simple to under- - td and is along the lines suggested by our studies of beet effeet am " union 189"t pwpestie...38, Feb. 1931. 189. Hodge, J. C., Amer. Weld. Soc. Jnl. 9, 93-116, Oct. 1930. 190. Hawkins, H. W., Proc. Rugby Engg. Soc., 27, 41-65 (1), (1932-1933...Construction, Gosstroyizdat, Moscow, 1933, 43-46; All- Union Scientific Engg. Soc. Welders, Research Works on Welding, 1934, 163-171. 262. Iller, R. W. Autog

Apollo Program Summary Report: Synopsis of the Apollo Program Activities and Technology for Lunar Exploration

NASA Technical Reports Server (NTRS)

1975-01-01

Overall program activities and the technology developed to accomplish lunar exploration are discussed. A summary of the flights conducted over an 11-year period is presented along with specific aspects of the overall program, including lunar science, vehicle development and performance, lunar module development program, spacecraft development testing, flight crew summary, mission operations, biomedical data, spacecraft manufacturing and testing, launch site facilities, equipment, and prelaunch operations, and the lunar receiving laboratory. Appendixes provide data on each of the Apollo missions, mission type designations, spacecraft weights, records achieved by Apollo crewmen, vehicle histories, and a listing of anomalous hardware conditions noted during each flight beginning with Apollo 4.

Monitoring and treatment of coagulation abnormalities in burn patients. an international survey on current practices

PubMed Central

Lavrentieva, A.; Depetris, N.; Kaimakamis, E.; Berardino, M.; Stella, M.

2016-01-01

Summary The magnitude of coagulation abnormalities, and the definition and treatment of coagulopathy in burn patients are inadequately understood and continue to be discussed in the literature. We aimed to analyse physicians’ views on monitoring and treating coagulation abnormalities in burn patients. A total of 350 questionnaires were distributed electronically to burn ICU physicians. Participation was voluntary and anonymous. Responses were analysed electronically and comparisons were made according to the region of the ICU or the specialty of the physician. Of the 350 questionnaires distributed, 55 (15.7%) were returned. The majority of burn specialists consider sepsis-induced coagulopathy to be the most frequent coagulopathy in burn patients, and 74.5% declare that they do not use any specific definition/scoring system in their department to detect coagulopathy. The majority of specialists (70.8%) use standard coagulation tests. The most frequent indications for plasma transfusion are massive bleeding (32.8%) and Disseminated Intravascular Coagulation syndrome treatment (20%). The main specific factors reported in our study are cryoprecipitate (23.2%) and fibrinogen concentrate (18.9%). 21.1% of respondents state that they do not use any specific coagulation factor substitution in burn patients. Specific coagulation factor substitution is not a routine practice. The low response rate precludes the generalization of our results. PMID:28149244

Statistical validation of brain tumor shape approximation via spherical harmonics for image-guided neurosurgery.

PubMed

Goldberg-Zimring, Daniel; Talos, Ion-Florin; Bhagwat, Jui G; Haker, Steven J; Black, Peter M; Zou, Kelly H

2005-04-01

Surgical planning now routinely uses both two-dimensional (2D) and three-dimensional (3D) models that integrate data from multiple imaging modalities, each highlighting one or more aspects of morphology or function. We performed a preliminary evaluation of the use of spherical harmonics (SH) in approximating the 3D shape and estimating the volume of brain tumors of varying characteristics. Magnetic resonance (MR) images from five patients with brain tumors were selected randomly from our MR-guided neurosurgical practice. Standardized mean square reconstruction errors (SMSRE) by tumor volume were measured. Validation metrics for comparing performances of the SH method against segmented contours (SC) were the dice similarity coefficient (DSC) and standardized Euclidean distance (SED) measure. Tumor volume range was 22,413-85,189 mm3, and range of number of vertices in triangulated models was 3674-6544. At SH approximations with degree of at least 30, SMSRE were within 1.66 x 10(-5) mm(-1). Summary measures yielded a DSC range of 0.89-0.99 (pooled median, 0.97 and significantly >0.7; P < .001) and an SED range of 0.0002-0.0028 (pooled median, 0.0005). 3D shapes of tumors may be approximated by using SH for neurosurgical applications.

A Summary of Publications on Methods and Tools for Assessing Cumulative Risk, Project Summary

EPA Science Inventory

This collection of eight publications on cumulative risk assessment was developed collaboratively among scientists within EPA’s Office of Research and Development and three other organizations. These include scientific collaborations through an Interagency Agreement with Argonne...

The NASA High Speed ASE Project: Computational Analyses of a Low-Boom Supersonic Configuration

NASA Technical Reports Server (NTRS)

Silva, Walter A.; DeLaGarza, Antonio; Zink, Scott; Bounajem, Elias G.; Johnson, Christopher; Buonanno, Michael; Sanetrik, Mark D.; Yoo, Seung Y.; Kopasakis, George; Christhilf, David M.;

Determining the Sensitivity of CAT-ASVAB (Computerized Adaptive Testing- Armed Services Vocational Aptitude Battery) Scores to Changes in Item Response Curves with the Medium of Administration

DTIC Science & Technology

1986-08-01

most examinees. Therefore it appears psychometrically ac - ceptable for the CAT -ASVAB project to proceed without item recalibration based on...MEMORANDUM DETERMINING THE SENSITIVITY OF CAT -ASVAB SCORES TO CHANGES IN ITEM RESPONSE CURVES WITH THE MEDIUM OF ADMINISTRATION D. R. Divgi...Subj: Center for Naval Analyses Research Memorandum 86-189 End: (1) CNA Research Memorandum 86-189, "Determining the Sensitivity of CAT -ASVAB

Green Infrastructure for Stormwater Control: Gauging its Effectiveness with Community Partners, Summary of EPA GI Reports

EPA Science Inventory

This document is a summary of the green infrastructure reports, journal articles, and conference proceedings published to date. This summary will be updated as more reports are completed. The Environmental Protection Agency’s Office of Research and Development has an ambitious ...

Does This Patient Have Infectious Mononucleosis?: The Rational Clinical Examination Systematic Review.

PubMed

Ebell, Mark H; Call, Marlene; Shinholser, JoAnna; Gardner, Jack

2016-04-12

Early, accurate diagnosis of infectious mononucleosis can help clinicians target treatment, avoid antibiotics, and provide an accurate prognosis. To systematically review the literature regarding the value of the clinical examination and white blood cell count for the diagnosis of mononucleosis. The databases of PubMed (from 1966-2016) and EMBASE (from 1947-2015) were searched and a total of 670 articles and abstracts were reviewed for eligibility. Eleven studies were included that reported data sufficient to calculate sensitivity, specificity, or both for clinical examination findings and white blood cell count parameters compared with a valid reference standard. Data were abstracted from each article by at least 2 reviewers, with discrepancies reconciled by consensus. Clinical findings evaluated in only 1 study are reported with sensitivity, specificity, likelihood ratio (LR), and 95% confidence interval, which were calculated from the available data. Findings evaluated in only 2 studies were summarized with their range, findings evaluated in 3 studies were summarized with a univariate random-effects summary, and findings evaluated in 4 or more studies were summarized with a bivariate random-effects meta-analysis. Sensitivity, specificity, and LRs for the diagnosis of mononucleosis. Mononucleosis is most commonly present among patients aged 5 to 25 years (especially those aged 16-20 years, among whom approximately 1 in 13 patients presenting with sore throat has mononucleosis). The likelihood of mononucleosis is reduced with the absence of any lymphadenopathy (summary sensitivity, 0.91; positive LR range, 0.23-0.44), whereas the likelihood increases with the presence of posterior cervical adenopathy (summary specificity, 0.87; positive LR, 3.1 [95% CI, 1.6-5.9]), inguinal or axillary adenopathy (specificity range, 0.82-0.91; positive LR range, 3.0-3.1), palatine petechiae (specificity, 0.95; positive LR, 5.3 [95% CI, 2.1-13]), and splenomegaly (specificity range, 0.71-0.99; positive LR range, 1.9-6.6). Symptoms are of limited value for the diagnosis of mononucleosis; sore throat and fatigue are sensitive (range, 0.81-0.83) but nonspecific. The presence of atypical lymphocytosis significantly increases the likelihood of mononucleosis (summary LR, 11.4 [95% CI, 2.7-35] for atypical lymphocytes ≥10%, 26 [95% CI, 9.6-68] for those with 20%, and 50 [95% CI, 38-64] for those with 40%). The combination of a patient having greater than 50% lymphocytes and greater than 10% atypical lymphocytes also is useful (specificity, 0.99; positive LR, 54 [95% CI, 8.4-189]). In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical lymphocytosis is associated with an increased likelihood of mononucleosis.

On the development of a theory of traveler attitude-behavior interrelationships. Volume 3 : executive summary : overview of methods, results, and conclusions

DOT National Transportation Integrated Search

1978-08-01

The executive summary of this Final Report offers an overview of : methods, results, and conclusions which support the development of a : theory of traveler attitude-behavior interrelationships. Such a theory : will be useful in the design of transpo...

Oyster Shell Dredging in Atchafalaya Bay and Adjacent Waters, Louisiana. Draft Environmental Impact Statement and Appendixes,

DTIC Science & Technology

1987-04-01

importance with the development of the Atchafalaya Delta region (Thompson and Deegan , 1980). Although several works have been prepared which dealt with the...47:189-228. Craig , N.J., R.E. Turner, and J.W. Day, Jr. 1979. Land loss in coastal Louisiana (USA). J. Environ. Management 3(1): 133-144. Cratsley, D.W...University, Baton Rouge. 285 pp. EI-114 Thompson, B.A and L.A. Deegan . 1983. The Atchafalaya River delta: a "new" fishery nursery with recommendations for

Workforce Development Institute: 1995 Summary Report.

ERIC Educational Resources Information Center

Jones, Ansleigh, Ed.

This report provides a summary of the American Association of Community Colleges' (AACC's) second Workforce Development Institute (WDI), held January 18 to 21, 1995 to provide community college workforce service providers with resources and training. Introductory materials describe the WDI, its regional forums, the AACC's related National…

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing.

PubMed

Lord, Megan S; Ellis, April L; Farrugia, Brooke L; Whitelock, John M; Grenett, Hernan; Li, Chuanyu; O'Grady, Robert L; DeCarlo, Arthur A

2017-03-28

The repair of dermal wounds, particularly in the diabetic population, poses a significant healthcare burden. The impaired wound healing of diabetic wounds is attributed to low levels of endogenous growth factors, including vascular endothelial growth factor (VEGF), that normally stimulate multiple phases of wound healing. In this study, chitosan scaffolds were prepared via freeze drying and loaded with plasmid DNA encoding perlecan domain I and VEGF189 and analyzed in vivo for their ability to promote dermal wound healing. The plasmid DNA encoding perlecan domain I and VEGF189 loaded scaffolds promoted dermal wound healing in normal and diabetic rats. This treatment resulted in an increase in the number of blood vessels and sub-epithelial connective tissue matrix components within the wound beds compared to wounds treated with chitosan scaffolds containing control DNA or wounded controls. These results suggest that chitosan scaffolds containing plasmid DNA encoding VEGF189 and perlecan domain I have the potential to induce angiogenesis and wound healing. Copyright © 2017 Elsevier B.V. All rights reserved.

Characterization of the proton beam from an IBA Cyclone 18/9 with radiochromic film EBT2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sansaloni, F.; Lagares, J. I.; Arce, P.

2012-12-19

The use of radiochromic films is widespread in different areas of medical physics like radiotherapy and hadrontherapy; however, radiochromic films have been scarcely used in the characterization of proton or deuteron beams generated in biomedical cyclotrons. In this paper the radiochromic film EBT2 was used to study the beam size and the proton beam energy of an IBA Cyclone 18/9 cyclotron. The results indicate that the beam size can be easily measured at a very low expense; however, an accurate determination of the beam energy might require the implementation of certain experimental improvements.

Reconsidering the Rules for Space Security

DTIC Science & Technology

2008-04-01

orbit.187 Elon Musk , the owner of SpaceX, has invested $100 mil- lion of his own money and hopes to recoup his investment by developing another rocket...2007, http://www.space.com/news/070328_spacex_falc1test_updt.html. 188. NSSLRP, National Security Space Launch Report, 35. 189. Musk is currently...expen- sive than he anticipated. Even before the March 2006 inaugural Falcon 1 launch failure, Musk had invested twice as much of his own money in SpaceX

Measuring software development characteristics in the local environment. [considering project requirements for spacecraft control

NASA Technical Reports Server (NTRS)

Basili, V. R.; Zelkowitz, M. V.

1978-01-01

In a brief evaluation of software-related considerations, it is found that suitable approaches for software development depend to a large degree on the characteristics of the particular project involved. An analysis is conducted of development problems in an environment in which ground support software is produced for spacecraft control. The amount of work involved is in the range from 6 to 10 man-years. Attention is given to a general project summary, a programmer/analyst survey, a component summary, a component status report, a resource summary, a change report, a computer program run analysis, aspects of data collection on a smaller scale, progress forecasting, problems of overhead, and error analysis.

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge.

PubMed

Brayford, Simon; Bryce, Nicole S; Schevzov, Galina; Haynes, Elizabeth M; Bear, James E; Hardeman, Edna C; Gunning, Peter W

2016-05-23

At the leading edge of migrating cells, protrusion of the lamellipodium is driven by Arp2/3-mediated polymerization of actin filaments [1]. This dense, branched actin network is promoted and stabilized by cortactin [2, 3]. In order to drive filament turnover, Arp2/3 networks are remodeled by proteins such as GMF, which blocks the actin-Arp2/3 interaction [4, 5], and coronin 1B, which acts by directing SSH1L to the lamellipodium where it activates the actin-severing protein cofilin [6, 7]. It has been shown in vitro that cofilin-mediated severing of Arp2/3 actin networks results in the generation of new pointed ends to which the actin-stabilizing protein tropomyosin (Tpm) can bind [8]. The presence of Tpm in lamellipodia, however, is disputed in the literature [9-19]. Here, we report that the Tpm isoforms 1.8/9 are enriched in the lamellipodium of fibroblasts as detected with a novel isoform-specific monoclonal antibody. RNAi-mediated silencing of Tpm1.8/9 led to an increase of Arp2/3 accumulation at the cell periphery and a decrease in the persistence of lamellipodia and cell motility, a phenotype consistent with cortactin- and coronin 1B-deficient cells [2, 7]. In the absence of coronin 1B or cofilin, Tpm1.8/9 protein levels are reduced while, conversely, inhibition of Arp2/3 with CK666 leads to an increase in Tpm1.8/9 protein. These findings establish a novel regulatory mechanism within the lamellipodium whereby Tpm collaborates with Arp2/3 to promote lamellipodial-based cell migration. Copyright © 2016 Elsevier Ltd. All rights reserved.

Development of a Blended Instructional Model via Weblog to Enhance English Summary Writing Ability of Thai Undergraduate Students

ERIC Educational Resources Information Center

Termsinsuk, Saisunee

2015-01-01

The objective of this research and development was to develop an effective blended instructional model via weblog to enhance English summary writing ability of Thai undergraduate students. A sample group in the English program of Nakhon Ratchasima Rajabhat University was studied in academic year 2010-2013. The research instruments were an…

The Arts Educator and Children with Special Needs: Conference Report.

ERIC Educational Resources Information Center

CEMREL, Inc., St. Louis, MO.

The document contains eight summaries of position statements and a summary of strategies to develop personnel preparation programs arising from a national symposium on arts education for children with handicaps. Symposium participants devised five approaches for expanding the development of programs to train arts personnel to teach handicapped…

[Drug-related claims in the Norwegian system of compensation to patients].

PubMed

Baardseth, Mari; Lynghei, Ellen; Flåte, Sølvi; Spigset, Olav; Slørdal, Lars

2013-01-22

Patients subjected to drug-related injuries can, in accordance with Norwegian legislation, seek compensation from the Norwegian System of Patient Injury Compensation (NPE). The aim of this study was to examine what drugs and injuries instigate claims against NPE, and how these cases are resolved. We have assessed anonymised summaries of 992 consecutive indemnity applications received and evaluated by NPE over the period 2003-2009. We recorded the age and gender of applicants, treatment diagnosis, drugs implicated, outcome, and NPE's decision in each case. A total of 964 claims were included. The most commonly implicated drugs were those affecting the nervous system (34.6%) and the musculoskeletal system (26.1%). Rofecoxib at 18.9% was the predominant single drug implicated. In two-thirds of the cases, adverse effects were given as the reason for the claim, whereas the last one-third consisted of claims for medication errors. The most common injuries were related to cardiovascular diseases (28.7%) or non-specific conditions (17.5%). 8.4% of the cases related to fatalities. In all, 26.3% of the claims resulted in compensations. Few patients made use of the NPE. Most of the compensation claims in the years 2003-2009 involved rofecoxib and psychoactive drugs, and the majority of claims were rejected.

Assessment of surgical discharge summaries and evaluation of a new quality improvement model.

PubMed

Stein, Ran; Neufeld, David; Shwartz, Ivan; Erez, Ilan; Haas, Ilana; Magen, Ada; Glassberg, Elon; Shmulevsky, Pavel; Paran, Haim

2014-11-01

Discharge summaries after hospitalization provide the most reliable description and implications of the hospitalization. A concise discharge summary is crucial for maintaining continuity of care through the transition from inpatient to ambulatory care. Discharge summaries often lack information and are imprecise. Errors and insufficient recommendations regarding changes in the medical regimen may harm the patient's health and may result in readmission. To evaluate a quality improvement model and training program for writing postoperative discharge summaries for three surgical procedures. Medical records and surgical discharge summaries were reviewed and scored. Essential points for communication between surgeons and family physicians were included in automated forms. Staff was briefed twice regarding required summary contents with an interim evaluation. Changes in quality were evaluated. Summaries from 61 cholecystectomies, 42 hernioplasties and 45 colectomies were reviewed. The average quality score of all discharge summaries increased from 72.1 to 78.3 after the first intervention (P < 0.0005) to 81.0 following the second intervention. As the discharge summary's quality improved, its length decreased significantly. Discharge summaries lack important information and are too long. Developing a model for discharge summaries and instructing surgical staff regarding their contents resulted in measurable improvement. Frequent interventions and supervision are needed to maintain the quality of the surgical discharge summary.

Development of Geography and Geology Terminology in British Sign Language

NASA Astrophysics Data System (ADS)

Meara, Rhian; Cameron, Audrey; Quinn, Gary; O'Neill, Rachel

2016-04-01

The BSL Glossary Project, run by the Scottish Sensory Centre at the University of Edinburgh focuses on developing scientific terminology in British Sign Language for use in the primary, secondary and tertiary education of deaf and hard of hearing students within the UK. Thus far, the project has developed 850 new signs and definitions covering Chemistry, Physics, Biology, Astronomy and Mathematics. The project has also translated examinations into BSL for students across Scotland. The current phase of the project has focused on developing terminology for Geography and Geology subjects. More than 189 new signs have been developed in these subjects including weather, rivers, maps, natural hazards and Geographical Information Systems. The signs were developed by a focus group with expertise in Geography and Geology, Chemistry, Ecology, BSL Linguistics and Deaf Education all of whom are deaf fluent BSL users.

Sulfated polysaccharide from the leaves of Artemisia Princeps activates heparin cofactor II independently of the Lys173 and Arg189 residues of heparin cofactor II.

PubMed

Hayashi, T; Hayakawa, Y; Hayashi, T; Sasaki, H; Sakuragawa, N

1997-07-01

A sulfated polysaccharide (AFE-HCD) purified from the leaves of Artemisia princeps Pamp selectively accelerated the rate of thrombin inhibition by heparin cofactor II (HCII). By using plasma derived HCII and bacterial expressed recombinant HCII molecules, the interaction between each HCII molecule and AFE-HCD was analyzed. AFE-HCD accelerated thrombin inhibition by plasma derived HCII or bacterial expressed wild type HCII to the same extent (IC50: 0.056 micrograms/ml for plasma derived HCII and 0.066 micrograms/ml for recombinant HCII under the experimental condition). The recombinant HCII (rHCII) molecule with Lys173-->Leu or Arg189-->His substitution, which is defective in interactions with heparin and dermatan sulfate, respectively, is activated by AFE-HCD to inhibit thrombin in a manner similar to wild type rHCII. These results suggested that activation of HCII was independent of its Lys173 or Arg189 residue. Although AFE-HCD is a selective activator of HCII like dermatan sulfate, the amino acid residue required for the activation of HCII was distinct form that of dermatan sulfate as well as heparin.

Reading Comprehension II. Bibliographies and Summaries of Selected Articles. Volume 6. Research Review Series.

ERIC Educational Resources Information Center

MacGinitie, Walter H.; And Others

Summaries of several papers are presented to develop a working theoretical analysis of reading comprehension and an understanding of development in language comprehension based upon empirical studies. Contributions from the areas of assessment, artificial intelligence, cognition (including schema theory), instruction, linguistics, learning…

Assessment of the components of the Kalimantan and Sulawesi power development project: Volume 1 -- Executive summary. Export trade information

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-03-31

This report, conducted by Utility Consulting was funded by the US Trade and Development Agency. The report concerns a power development project on the islands of Kalimantan and Sulawesi. This is Volume 1, The Executive Summary, and it summarizes the findings, conclusions and recommendations of this three volume study.

Solid State Lighting OLED Manufacturing Roundtable Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2010-03-31

Summary of a meeting of OLED experts to develop proposed priority tasks for the Manufacturing R&D initiative, including task descriptions, discussion points, recommendations, and presentation highlights.

User Guide for State Summaries

EPA Pesticide Factsheets

The EPA developed state-level summaries of chemical and water use using the project database developed from FracFocus 1.0 disclosures with some limited background information on oil and gas production, geology, and regulations for the state.

Development of the Runway Incursion Advisory and Alerting System (RIAAS): Research Summary

NASA Technical Reports Server (NTRS)

Jones, Denise R. (Technical Monitor); Cassell, Rick

2005-01-01

This report summarizes research conducted on an aircraft based Runway Incursion Advisory and Alerting System (RIAAS) developed under a cooperative agreement between Rannoch Corporation and the NASA Langley Research Center. A summary of RIAAS is presented along with results from simulation and flight testing, safety benefits, and key technical issues.

Evaluating Fluorscence-Based Metrics for Early Detection of ...

EPA Pesticide Factsheets

Summary: This paper discusses the results of an ongoing Water Research Foundation project on developing a fluorescence sensor system for early detection of distribution system nitrification Summary: This paper discusses the results of an ongoing Water Research Foundation project on developing a fluorescence sensor system for early detection of distribution system nitrification

Computerized summary scoring: crowdsourcing-based latent semantic analysis.

PubMed

Li, Haiying; Cai, Zhiqiang; Graesser, Arthur C

2017-11-03

In this study we developed and evaluated a crowdsourcing-based latent semantic analysis (LSA) approach to computerized summary scoring (CSS). LSA is a frequently used mathematical component in CSS, where LSA similarity represents the extent to which the to-be-graded target summary is similar to a model summary or a set of exemplar summaries. Researchers have proposed different formulations of the model summary in previous studies, such as pregraded summaries, expert-generated summaries, or source texts. The former two methods, however, require substantial human time, effort, and costs in order to either grade or generate summaries. Using source texts does not require human effort, but it also does not predict human summary scores well. With human summary scores as the gold standard, in this study we evaluated the crowdsourcing LSA method by comparing it with seven other LSA methods that used sets of summaries from different sources (either experts or crowdsourced) of differing quality, along with source texts. Results showed that crowdsourcing LSA predicted human summary scores as well as expert-good and crowdsourcing-good summaries, and better than the other methods. A series of analyses with different numbers of crowdsourcing summaries demonstrated that the number (from 10 to 100) did not significantly affect performance. These findings imply that crowdsourcing LSA is a promising approach to CSS, because it saves human effort in generating the model summary while still yielding comparable performance. This approach to small-scale CSS provides a practical solution for instructors in courses, and also advances research on automated assessments in which student responses are expected to semantically converge on subject matter content.

Installation Restoration Program Environmental Technology Development. Biodegradation of DIMP, Dieldrin, Isodrin, DBCP, and PCPMSO in Rocky Mountain Arsenal Soils

DTIC Science & Technology

1989-01-30

D-007 & Hazardous Materials Agency 1 CETHA-TE Task No. 11 . ADDRESS (City, State, and ZIP Code) 10. SOURCE OF FUNDING NUMBERS ATTN: CETHA-TE-D...PROGRAM IPROJECT TASK IWORK UNIT Aberdeen Proving Ground, MD 21010-5401 ELEMENT NO. NO. NO. ACCESSION NO. 1 . TITLE (Include SecurityClassification...Peter J. Marks 3a. TYPE OF REPORT 13b. TIME COVERED T14. DATE OF REPORT (Year, Month, Day) 115. PAGE COUNT Final FROM 1 /87 TO_1/89 11989 January 3 6

Development of NASA's Sample Cartridge Assembly: Summary of GEDS Design, Development Testing, and Thermal Analyses

NASA Technical Reports Server (NTRS)

O'Connor, Brian; Hernandez, Deborah; Hornsby, Linda; Brown, Maria; Horton-Mullins, Kathryn

2017-01-01

Outline: Background of ISS (International Space Station) Material Science Research Rack; NASA SCA (Sample Cartridge Assembly) Design; GEDS (Gravitational Effects in Distortion in Sintering) Experiment Ampoule Design; Development Testing Summary; Thermal Modeling and Analysis. Summary: GEDS design development challenging (GEDS Ampoule design developed through MUGS (Microgravity) testing; Short duration transient sample processing; Unable to measure sample temperatures); MUGS Development testing used to gather data (Actual LGF (Low Gradient Furnace)-like furnace response; Provided sample for sintering evaluation); Transient thermal model integral to successful GEDS experiment (Development testing provided furnace response; PI (Performance Indicator) evaluation of sintering anchored model evaluation of processing durations; Thermal transient model used to determine flight SCA sample processing profiles).

Ada (Trade Name) Compiler Validation Summary Report: International Business Machines Corporation. IBM Development System for the Ada Language System, Version 1.1.0, IBM 4381 under MVS.

DTIC Science & Technology

1988-05-22

TITLE (andSubtile) 5. TYPE OF REPORT & PERIOD COVERED Ada Compler Validation Summary Report: 22 May 1987 to 22 May 1988 International Business Machines...IBM Development System for the Ada Language System, Version 1.1.0, International Business Machines Corporation, Wright-Patterson AFB. IBM 4381 under...SUMMARY REPORT: International Business Machines Corporation IBM Development System f’or the Ada Language System, Version 1.1.0 IBM 4381 under MVS

Interoperability Assets for Patient Summary Components: A Gap Analysis.

PubMed

Heitmann, Kai U; Cangioli, Giorgio; Melgara, Marcello; Chronaki, Catherine

2018-01-01

The International Patient Summary (IPS) standards aim to define the specifications for a minimal and non-exhaustive Patient Summary, which is specialty-agnostic and condition-independent, but still clinically relevant. Meanwhile, health systems are developing and implementing their own variation of a patient summary while, the eHealth Digital Services Infrastructure (eHDSI) initiative is deploying patient summary services across countries in the Europe. In the spirit of co-creation, flexible governance, and continuous alignment advocated by eStandards, the Trillum-II initiative promotes adoption of the patient summary by engaging standards organizations, and interoperability practitioners in a community of practice for digital health to share best practices, tools, data, specifications, and experiences. This paper compares operational aspects of patient summaries in 14 case studies in Europe, the United States, and across the world, focusing on how patient summary components are used in practice, to promote alignment and joint understanding that will improve quality of standards and lower costs of interoperability.

Design and implementation of web-based discharge summary note based on service-oriented architecture.

PubMed

Chen, Chi-Huang; Hsieh, Sung-Huai; Su, Yu-Shuan; Hsu, Kai-Ping; Lee, Hsiu-Hui; Lai, Feipei

2012-02-01

Discharge summary note is one of the essential clinical data in medical records, and it concisely capsules a patient's status during hospitalization. In the article, we adopt web-based architecture in developing a new discharge summary system for the Healthcare Information System of National Taiwan University Hospital, to improve the traditional client/sever architecture. The article elaborates the design approaches and implementation illustrations in detail, including patients' summary query and searching, model and phrase quoted, summary check list, major editing blocks as well as other functionalities. The system has been on-line and achieves successfully since October 2009.

N-Cadherin in Prostate Cancer: Downstream Pathways and their Translational Application for Castrate-Resistant Prostate Cancer

DTIC Science & Technology

2012-09-01

2008). 22. Mason , M.J., Fan, G ., Plath, K., Zhou, Q. & Horvath , S. Signed weighted gene co-expression network analysis of transcriptional regulation... G , Gimond C. The dual-specificity MAP kinase phosphatases: critical roles in development and cancer. Am J Physiol Cell Physiol.299:C189-202. 9...Tanaka H. KE, Tran C. P., Miyazaki H., Yamashiro J., Shimomura T., Lada F., Wada R., Juang J., Vessella R. L., An J., Horvath S., Gleave M., Rettig M

The comparison of severity and prevalence of major depressive disorder, general anxiety disorder and eating disorders before and after bariatric surgery.

PubMed

Matini, Diana; Ghanbari Jolfaei, Atefeh; Pazouki, Abdolreza; Pishgahroudsari, Mohadeseh; Ehtesham, Mehdi

2014-01-01

Severe obesity is highly co-morbid with psychiatric disorders and may have effect on the quality of life. This study aimed to compare severity and prevalence rate of depression, anxiety and eating disorders and quality of life in severe obese patients before and 6 months after the gastric bypass surgery. This was a prospective observational study which conducted at Hazarat Rasool-Akram Hospital in Tehran, 2012. Questionnaires included demographic questions, eating disorder Inventory (EDI), The Short Form Health Survey (SF-36) for quality of life, Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I) and Hamilton Rating Scale for Depression (HRSD) and anxiety (HRSA). Participants were interviewed two times, before surgery and six months after, to determine changes of the disorders. Patients with the history of bariatric surgery, individuals younger than 18 year old and those who disagreed to join the study were excluded. In assessing the eating disorder inventory-3rd version (EDI-3), Significant reduction in drive for thinness (DT) (p= 0.010), bulimia (B) (p< 0.0001) and body dissatisfaction mean (BD) (0.038) was observed at the 6-month follow-up. At this period, the mean for physical component summary of SF36, significantly decreased (p< 0.0001), however mental component summary did not significantly differ (p= 0.368); Also differences in severity of anxiety (p= 0.852), and depression in HRSD (p= 0.311), prevalence of depression (p= 0.189) and prevalence of general anxiety disorder according to SCID (p=0.167) did not differ significantly, at this period. Although weight loss after bariatric surgery improved the physical component of quality of life, this improvement did not affect the mental aspect of life, depression and anxiety and it seems that these psychopathologies need attention and treatment in addition to weight loss treatments in patients with obesity.

A Study on Creating Writing Strategy and Evaluation Tool for Book Summary

ERIC Educational Resources Information Center

Konuk, Sümeyye; Ören, Zeyneb; Benzer, Ahmet; Sefer, Aysegül

2016-01-01

Summarizing is restating the most important ideas from an original text briefly. Students often need summary writing skill along the education life since it provides understanding and remembering the reading material. This study aims to apply book summary writing strategy which is based on in-class implementations, and to develop the students book…

A Development Program for Metropolitan Junior College, Kansas City. Volume One: Executive Summary.

ERIC Educational Resources Information Center

Little (Arthur D.), Inc., San Francisco, CA.

This five-part report provides a summary of the findings and recommendations resulting from a study conducted to determine the most suitable sites for three Metropolitan Junior College (MJC) campuses and to formulate long-range plans for the development of a comprehensive institution. After presenting introductory material, Part I notes problems…

NASA Remediation Technology Collaboration Development Task, Overview and Project Summaries

NASA Technical Reports Server (NTRS)

Romeo, James G.

2014-01-01

An overview presentation of NASA's Remediation Technology Collaboration Development Task including the following project summaries: in situ groundwater monitor, in situ chemical oxidation, in situ bioremediation, horizontal multi-port well, and high resolution site characterization.

Summary Report of a Peer Involvement Workshop on the Development of An Exposure Factors Handbook for the Aging

EPA Science Inventory

EPA has released the final workshop report, Summary Report of a Peer Involvement Workshop on the Development of an Exposure Factors Handbook for the Aging. This report provides an overview of a meeting held February 14-15, 2007 which was organized to discuss factors affec...

Superdeformed shapes and configurations in thallium nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reviol, W.; Mueller, W.F.; Riedinger, L.L.

1997-09-01

Superdeformation studies in {sup 189,191,192}Tl at Gammasphere are discussed. New results on {sup 191}Tl are the observation of interband transitions between the signature partner E2 bands and the measurement of an average quadrupole moment (Q{sub 0} = 18 {+-} 1 eb) for these superdeformed structures. These data enable them to derive absolute M1 strengths and confirm that the 81st proton occupies the [642]5/2 orbital. Tentative data for one superdeformed sequence in {sup 189}Tl are consistent with the prediction of a decrease in quadrupole deformation for the lightest nuclei at the limit of this island of superdeformation.

Do evidence summaries increase policy-makers' use of evidence from systematic reviews: A systematic review protocol.

PubMed

Petkovic, Jennifer; Welch, Vivian; Tugwell, Peter

2015-09-28

Systematic reviews are important for decision-makers. They offer many potential benefits but are often written in technical language, are too long, and do not contain contextual details which makes them hard to use for decision-making. There are many organizations that develop and disseminate derivative products, such as evidence summaries, from systematic reviews for different populations or subsets of decision-makers. This systematic review will assess the effectiveness of systematic review summaries on increasing policymakers' use of systematic review evidence and to identify the components or features of these summaries that are most effective. We will include studies of policy-makers at all levels as well as health-system managers. We will include studies examining any type of "evidence summary," "policy brief," or other products derived from systematic reviews that present evidence in a summarized form. The primary outcomes are the following: (1) use of systematic review summaries decision-making (e.g., self-reported use of the evidence in policy-making, decision-making) and (2) policy-maker understanding, knowledge, and/or beliefs (e.g., changes in knowledge scores about the topic included in the summary). We will conduct a systematic review of randomized controlled trials (RCTs), non-randomized controlled trials (NRCTs), controlled before-after studies (CBA), and interrupted time series (ITS) studies. The results of this review will inform the development of future systematic review summaries to ensure that systematic review evidence is accessible to and used by policy-makers making health-related decisions.

Mercury Lander Mission Concept Study Summary

NASA Astrophysics Data System (ADS)

Eng, D. A.

2018-05-01

Provides a summary of the Mercury Lander Mission Concept Study performed as part of the last Planetary Decadal Survey. The presentation will focus on engineering trades and the challenges of developing a Mercury lander mission.

Childhood burns: an analysis of 124 admissions in the Gaza Strip

PubMed Central

Elsous, A.; Salah, M.; Ouda, M.

2015-01-01

Summary Burns are a serious public health problem among paediatrics. Little is known about the epidemiological profile and outcomes of hospitalized paediatric burns in the Gaza Strip. A cross-sectional retrospective review was conducted of medical records of patients aged 15 years and below, admitted to the Al Alamy burn centre in the Al Shifa Medical Complex from 30 June, 2013 to 01 July, 2014. There were 189 admissions; 124 (65.6%) of them were below 15 years, their mean age ± SD being 4.02 ± 2.85 years. 72 of these cases (58.1%) were males, giving a male to female ratio of 1.6:1. 89.5% of the injuries were accidents and 96% were home-located. Scalds, which were a common cause of burns, represented 83.9% of cases. Mean TBSA was 10.72 ± 8.15%: half of the patients (50.8%) sustained second-degree burns, while 34.7% were a mix of second- and third-degree. Mean length of hospital stay was 10.23 ± 10.60 days. Only two children died during the study period, giving a case fatality rate and total mortality rate of 1.6% and 1.0% respectively. In conclusion, there is a need to focus on home safety and parents’ education as a means of reducing childhood burns. PMID:27777545

The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries.

PubMed

Costa, A C C; Coelho, E B; Lanchote, V L; Correia, B V; Abumansur, J T; Lauretti, G R; de Moraes, N V

2017-08-01

Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene encoding OATP1A2) genetic polymorphism on ROC pharmacokinetics was never described before. The objective of this work was to evaluate the influence of genetic polymorphisms of SLCO1A2 on the pharmacokinetics of rocuronium (ROC). Patients undergoing elective surgeries under general anesthesia using rocuronium as a neuromuscular blocker were genotyped for SLCO1A2 polymorphisms in the coding region (41A>G, 382A>T, 404A>T, 502C>T, 516A>C, 559G>A, 830C>A, and 833delA) and in the promoter region (-1105G>A, -1032G>A, -715T>C, -361G>A, and -189_-188insA). Rocuronium pharmacokinetic parameters were estimated by non-compartmental analysis. None of the patients had heterozygous or homozygous variant of 404A>T, 382A>T, 502C>T, 833delA, 830C>A, 41A>G, and -715T>C. A linkage disequilibrium was found between -1105G>A and -1032G>A genotypes. Patients genotyped as -A or AA (n = 17) for SLCO1A2 -189_-188InsA showed reduced total clearance of ROC compared to patients genotyped as -/- (n = 13) (151.6 vs 207.1 mL/min, p ≤ 0.05). The pharmacokinetics parameters of ROC were not significantly different between other SLCO1A2 genotypes. SLCO1A2 -189_-188InsA polymorphism is related to the reduced clearance of rocuronium in patients submitted to elective surgeries under general anesthesia. NCT 02399397 ( ClinicalTrials.gov ).

2004 South Dakota motor vehicle traffic crash summary

DOT National Transportation Integrated Search

2005-01-01

The South Dakota Motor Vehicle Traffic Crash Summary was developed to provide an overview of : the South Dakota traffic crash picture, as well as make frequently requested information available. : Beginning in 2004, South Dakota developed its Crash D...

2005 South Dakota motor vehicle traffic crash summary

DOT National Transportation Integrated Search

2006-05-01

The South Dakota Motor Vehicle Traffic Crash Summary was developed to provide an overview of : the South Dakota traffic crash picture, as well as make frequently requested information available. : Beginning in 2004, South Dakota developed its Crash D...

The European Perspective of HRD: A Debate on Selected Issues Put Forward By the EHRD Network. Symposium at ECER (Lisbon, Portugal, September 11-14, 2002).

ERIC Educational Resources Information Center

Manning, Sabine, Ed.

This document contains 13 presentations/discussion summaries and 10 supporting 'thesis' papers from a symposium on selected issues in human resources development (HRD) in Europe. The following summaries are included: "Introduction" (Sabine Manning); "Developing Flexibility in Pursuit of Competitiveness" (Nick Boreham);…

Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis.

PubMed

Santos, Ana M; Peña, Paola; Avila, Mabel; Briceño, Ignacio; Jaramillo, Carlos; Vargas-Alarcon, Gilberto; Rueda, Juan C; Saldarriaga, Eugenia-Lucia; Angarita, Jose-Ignacio; Martinez-Rodriguez, Nancy; Londono, John

2017-04-01

There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, HLA-DRB1*01 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB1*04 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this population, we found a strong association between the presence of HLA-B27 and the diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were associated in a cohort of patients with SpA from Colombia.

A Summary of the Foundation Research Program.

DTIC Science & Technology

1980-03-01

Electrical Engineering Sponsor: NPS Foundation Research Program Objective: To develop a new method for solving transient electromagnetic problems. Summary...This is a new project that is still in the start up phase. During the nt"t year, our goal is to develop a new iterativ, in-’rse scattering method for...unlimited Prepared for: Chief of Naval Research Arlington, Virginia 22217 and Chief of Naval Development Washington, D. C. 20360 80 5 20091 NAVAL

A single-item global job satisfaction measure is associated with quantitative blood immune indices in white-collar employees.

PubMed

Nakata, Akinori; Irie, Masahiro; Takahashi, Masaya

2013-01-01

Although a single-item job satisfaction measure has been shown to be reliable and inclusive as multiple-item scales in relation to health, studies including immunological data are few. The purpose of this study was to evaluate the validity of single-item job and family life satisfaction based on its association with immune indices. A total of 189 white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), total T, and B cell counts as well as plasma immunoglobulin (Ig) G concentrations and completed single-item job and family life satisfaction measures, respectively. The response options for satisfaction measures were 'dissatisfied' (coded 1) to 'satisfied' (coded 4). Spearman's partial correlations controlling for cofactors revealed that increased job satisfaction was positively associated with NK cells (rsp=0.201, p=0.007) and IgG (rsp=0.178, p=0.018), while family life satisfaction was unrelated to immune indices. Those who reported a combination of low job/low family life satisfaction had significantly lower NK and higher B cell counts than those with a high job/high family life satisfaction. Our study suggests that the single-item summary measure of job satisfaction, but not family life satisfaction, may be a valid tool to evaluate immune status in healthy white-collar employees.

Active case finding of undetected tuberculosis among chronic coughers in a slum setting in Kampala, Uganda

PubMed Central

Sekandi, J. N.; Neuhauser, D.; Smyth, K.; Whalen, C. C.

2010-01-01

SUMMARY SETTING Kisenyi slum in peri-urban Kampala, Uganda. OBJECTIVES Using chronic cough (≥2 weeks) inquiry as a screening tool to identify undetected smear-positive tuberculosis (TB) cases and to describe the characteristics of smear-positive TB cases detected by active case finding. DESIGN A house-to-house survey was conducted in five randomly selected villages in Kampala between June and August 2005. A sample of households was visited; adults aged ≥15 years were consecutively interviewed to identify those with chronic cough. Three sputum specimens were collected and examined by smear microscopy. RESULTS Among 930 individuals, we identified 189 (20%) chronic coughers. Of these, we found 33 (18%) undiagnosed smear-positive cases. The newly detected cases had an even sex distribution (P = 0.47), a median age of 30 years, a median cough duration of 1 month and 55% had acid-fast bacilli 1+ sputum smear grade. CONCLUSION These findings suggest that active case finding could supplement DOTS to yield additional smear-positive TB cases, lead to early diagnosis and thus shorten the duration of infectiousness before effective chemotherapy is initiated. In communities such as Kisenyi, this is a feasible strategy that may prove useful for TB control, but its cost-effectiveness needs to be evaluated. Early health care seeking for cough should be emphasized. PMID:19335958

A Single-item Global Job Satisfaction Measure Is Associated with Quantitative Blood Immune Indices in White-collar Employees

PubMed Central

Nakata, Akinori; Irie, Masahiro; Takahashi, Masaya

2015-01-01

Although a single-item job satisfaction measure has been shown to be reliable and inclusive as multiple-item scales in relation to health, studies including immunological data are few. The purpose of this study was to evaluate the validity of single-item job and family life satisfaction based on its association with immune indices. A total of 189 white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), total T, and B cell counts as well as plasma immunoglobulin (Ig) G concentrations and completed single-item job and family life satisfaction measures, respectively. The response options for satisfaction measures were ‘dissatisfied’ (coded 1) to ‘satisfied’ (coded 4). Spearman’s partial correlations controlling for cofactors revealed that increased job satisfaction was positively associated with NK cells (rsp=0.201, p=0.007) and IgG (rsp=0.178, p=0.018), while family life satisfaction was unrelated to immune indices. Those who reported a combination of low job/low family life satisfaction had significantly lower NK and higher B cell counts than those with a high job/high family life satisfaction. Our study suggests that the single-item summary measure of job satisfaction, but not family life satisfaction, may be a valid tool to evaluate immune status in healthy white-collar employees. PMID:23196390

Generation of gas-phase sodiated arenes such as [(Na3(C6H4)+] from benzene dicarboxylate salts.

PubMed

Attygalle, Athula B; Chan, Chang-Ching; Axe, Frank U; Bolgar, Mark

2010-01-01

Upon collision-induced activation, gaseous sodium adducts generated by electrospray ionization of disodium salts of 1,2- 1,3-, and 1,4-benzene dicarboxylic acids (m/z 233) undergo an unprecedented expulsion of CO(2) by a rearrangement process to produce an ion of m/z 189 in which all three sodium atoms are retained. When isolated in a collision cell of a tandem-in-space mass spectrometer, and subjected to collision-induced dissociation (CID), only the m/z 189 ions derived from the meta and para isomers underwent a further CO(2) loss to produce a peak at m/z 145 for a sodiated arene of formula (Na(3)C(6)H(4))(+). This previously unreported m/z 145 ion, which is useful to differentiate meta and para benzene dicarboxylates from their ortho isomer, is in fact the sodium adduct of phenelenedisodium. Moreover, the m/z 189 ion from all three isomers readily expelled a sodium radical to produce a peak at m/z 166 for a radical cation [(*C(6)H(4)CO(2)Na(2))(+)], which then eliminated CO(2) to produce a peak at m/z 122 for the distonic cation (*C(6)H(4)Na(2))(+). Copyright 2009 John Wiley & Sons, Ltd.

BT-Nurse: computer generation of natural language shift summaries from complex heterogeneous medical data.

PubMed

Hunter, James; Freer, Yvonne; Gatt, Albert; Reiter, Ehud; Sripada, Somayajulu; Sykes, Cindy; Westwater, Dave

2011-01-01

The BT-Nurse system uses data-to-text technology to automatically generate a natural language nursing shift summary in a neonatal intensive care unit (NICU). The summary is solely based on data held in an electronic patient record system, no additional data-entry is required. BT-Nurse was tested for two months in the Royal Infirmary of Edinburgh NICU. Nurses were asked to rate the understandability, accuracy, and helpfulness of the computer-generated summaries; they were also asked for free-text comments about the summaries. The nurses found the majority of the summaries to be understandable, accurate, and helpful (p<0.001 for all measures). However, nurses also pointed out many deficiencies, especially with regard to extra content they wanted to see in the computer-generated summaries. In conclusion, natural language NICU shift summaries can be automatically generated from an electronic patient record, but our proof-of-concept software needs considerable additional development work before it can be deployed.

BT-Nurse: computer generation of natural language shift summaries from complex heterogeneous medical data

PubMed Central

Freer, Yvonne; Gatt, Albert; Reiter, Ehud; Sripada, Somayajulu; Sykes, Cindy; Westwater, Dave

2011-01-01

The BT-Nurse system uses data-to-text technology to automatically generate a natural language nursing shift summary in a neonatal intensive care unit (NICU). The summary is solely based on data held in an electronic patient record system, no additional data-entry is required. BT-Nurse was tested for two months in the Royal Infirmary of Edinburgh NICU. Nurses were asked to rate the understandability, accuracy, and helpfulness of the computer-generated summaries; they were also asked for free-text comments about the summaries. The nurses found the majority of the summaries to be understandable, accurate, and helpful (p<0.001 for all measures). However, nurses also pointed out many deficiencies, especially with regard to extra content they wanted to see in the computer-generated summaries. In conclusion, natural language NICU shift summaries can be automatically generated from an electronic patient record, but our proof-of-concept software needs considerable additional development work before it can be deployed. PMID:21724739

Involving patients in a multidisciplinary European consensus process and in the development of a 'patient summary of the consensus document for colon and rectal cancer care'.

PubMed

Boelens, Petra G; Taylor, Claire; Henning, Geoffrey; Marang-van de Mheen, Perla J; Espin, Eloy; Wiggers, Theo; Gore-Booth, Jola; Moss, Barbara; Valentini, Vincenzo; van de Velde, Cornelis J H

2014-01-01

High-quality cancer care should be accessible for patients and healthcare professionals. Involvement of patients as partners in guideline formation and consensus processes is still rarely found. EURECCA, short for European Registration of Cancer Care, is the platform to improve outcomes of cancer care by reducing variation in the diagnostic and treatment process. EURECCA acknowledges the important role of patients in implementation of consensus information in clinical practice. The aim of this article is to describe the process of involving patients in the consensus process and in developing the patient summary of the consensus for colon and rectal cancer care. The Delphi method for achieving consensus was used. Three online voting rounds and one tele-voting round were offered to an expert panel of oncology professionals and patient representatives. At four different stages, patients and/or patient representatives were involved in the process: (1) during the consensus process, (2) lecturing about the role of the patient, (3) development of the patient summary, and (4) testing the patient summary. Representatives were invited to the voting and commenting rounds of this process and given an equal vote. Although patients were not consulted during the planning stages of this process, patient involvement increased following the panel's discussion of the implementation of the consensus among the patient population. After the consensus meeting, the patient summary was written by patient representatives, oncologists and nurses. A selection of proactive patients reviewed the draft patient summary; responses were positive and several patient-reported outcomes were added. Questionnaires to evaluate the use and implementation of the patient summary in daily practice are currently being developed and tested. Patient consultation will be needed in future planning for selection of topics. The present study may function as a model for future consensus processes to involve patients at different stages and to implement both patient and healthcare professional versions in daily practice.

Naturalistic study of guideline implementation tool use via evaluation of website access and physician survey.

PubMed

Armstrong, Melissa J; Gronseth, Gary S; Dubinsky, Richard; Potrebic, Sonja; Penfold Murray, Rebecca; Getchius, Thomas S D; Rheaume, Carol; Gagliardi, Anna R

2017-01-13

Clinical guidelines support decision-making at the point-of-care but the onus is often on individual users such as physicians to implement them. Research shows that the inclusion of implementation tools in or with guidelines (GItools) is associated with guideline use. However, there is little research on which GItools best support implementation by individual physicians. The purpose of this study was to investigate naturalistic access and use of GItools produced by the American Academy of Neurology (AAN) to inform future tool development. Website accesses over six months were summarized for eight AAN guidelines and associated GItools published between July 2012 and August 2013. Academy members were surveyed about use of tools accompanying the sport concussion guideline. Data were analyzed using summary statistics and the Chi-square test. The clinician summary was accessed more frequently (29.0%, p < 0.001) compared with the slide presentation (26.8%), patient summary (23.2%) or case study (20.9%), although this varied by guideline topic. For the sport concussion guideline, which was accompanied by a greater variety of GItools, the mobile phone quick reference check application was most frequently accessed, followed by the clinician summary, patient summary, and slide presentation. For the sports concussion guideline survey, most respondents (response rate 21.8%, 168/797) were aware of the guideline (88.1%) and had read the guideline (78.6%). For GItool use, respondents indicated reading the reference card (51.2%), clinician summary (45.2%), patient summary (28.0%), mobile phone application (26.2%), and coach/athletic trainer summary (20.2%). Patterns of sports concussion GItool use were similar between respondents who said they had and had not yet implemented the guideline. Developers faced with resource limitations may wish to prioritize the development of printable or mobile application clinician summaries, which were accessed significantly more than other types of GItools. Further research is needed to understand how to optimize the design of such GItools.

EPA State-level Summaries of FracFocus 1 Hydraulic Fracturing Data

EPA Pesticide Factsheets

The EPA developed state-level summaries of chemical and water use using the project database developed from FracFocus 1.0 disclosures with some limited background information on oil and gas production, geology, and regulations for the state.

Maternal risk factors for HIV infection in infants in northeastern Brazil

PubMed Central

de Lemos, Lígia M.D.; Lippi, Joseph; Rutherford, George W.; Duarte, Gabriella S.; Martins, Nágyla G.R.; Santos, Victor S.; Gurgel, Ricardo Q.

2017-01-01

SUMMARY Introduction While the rate of vertically transmitted HIV infection has fallen in most regions of Brazil, there have been no similar decreases in northern and northeastern Brazil. Objective The objective of this study was to evaluate the risk factors associated with vertical transmission in the state of Sergipe in northeastern Brazil. Methods This was a retrospective cohort study. We recorded clinic and registry data for all HIV-infected pregnant women and exposed children diagnosed in Sergipe from 1990 to 2011. Results We identified 538 deliveries and 561 HIV-exposed infants (23 sets of twins). One hundred one (18.9%) infants were HIV-infected. In the multivariate analysis, infant antiretroviral prophylaxis was a significant protective factor (adjusted odds ratio (aOR) 0.07, 95% confidence interval (CI) 0.01–0.41, p=0.003). Breastfeeding was marginally associated with an increased odds of perinatal transmission (aOR 4.52, 95% CI 0.78–26.17, p = 0.092). The attributable risk percentage for breastfeeding over the study period was 91.0%. Transmission decreased from 91 per 100 live births before 1997 to 2 per 100 in 2011 following the adoption of the prevention protocol. Conclusion Transmission declined over the study period. The screening of pregnant women and timely initiation of prophylaxis and therapy are issues that require further attention. PMID:23791426

[An essay on Quebec's demographic development from 1534 to 2034].

PubMed

Charbonneau, H

1984-04-01

A general review of the development of the population of Quebec since 1534 is presented in the form of separate summaries for each 50-year period. Topics discussed include sources of data, estimates of the North American Indian population, and estimates of immigration. Some consideration is given to projections to the year 2034. (summary in ENG, SPA)

Induction of cell death by tospoviral protein NSs and the motif critical for cell death does not control RNA silencing suppression activity.

PubMed

Singh, Ajeet; Permar, Vipin; Jain, R K; Goswami, Suneha; Kumar, Ranjeet Ranjan; Canto, Tomas; Palukaitis, Peter; Praveen, Shelly

2017-08-01

Groundnut bud necrosis virus induces necrotic symptoms in different hosts. Previous studies showed reactive oxygen species-mediated programmed cell death (PCD) resulted in necrotic symptoms. Transgenic expression of viral protein NSs mimics viral symptoms. Here, we showed a role for NSs in influencing oxidative burst in the cell, by analyzing H 2 O 2 accumulation, activities of antioxidant enzymes and expression levels of vacuolar processing enzymes, H 2 O 2 -responsive microRNA 319a.2 plus its possible target metacaspase-8. The role of NSs in PCD, was shown using two NSs mutants: one in the Trp/GH3 motif (a homologue of pro-apototic domain) (NSs S189R ) and the other in a non-Trp/GH3 motif (NSs L172R ). Tobacco rattle virus (TRV) expressing NSs S189R enhanced the PCD response, but not TRV-NSs L172R , while RNA silencing suppression activity was lost in TRV-NSs L172R , but not in TRV-NSs S189R . Therefore, we propose dual roles of NSs in RNA silencing suppression and induction of cell death, controlled by different motifs. Copyright © 2017 Elsevier Inc. All rights reserved.

Effectiveness of real-time polymerase chain reaction assay for the detection of Mycobacterium tuberculosis in pathological samples: a systematic review and meta-analysis.

PubMed

Babafemi, Emmanuel O; Cherian, Benny P; Banting, Lee; Mills, Graham A; Ngianga, Kandala

2017-10-25

Rapid and accurate diagnosis of tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Many established diagnostic methods suffer from low sensitivity or delay of timely results and are inadequate for rapid detection of Mycobacterium tuberculosis (MTB) in pulmonary and extra-pulmonary clinical samples. This study examined whether a real-time polymerase chain reaction (RT-PCR) assay, with a turn-a-round time of 2 h, would prove effective for routine detection of MTB by clinical microbiology laboratories. A systematic literature search was performed for publications in any language on the detection of MTB in pathological samples by RT-PCR assay. The following sources were used MEDLINE via PubMed, EMBASE, BIOSIS Citation Index, Web of Science, SCOPUS, ISI Web of Knowledge and Cochrane Infectious Diseases Group Specialised Register, grey literature, World Health Organization and Centres for Disease Control and Prevention websites. Forty-six studies met set inclusion criteria. Generated pooled summary estimates (95% CIs) were calculated for overall accuracy and bivariate meta-regression model was used for meta-analysis. Summary estimates for pulmonary TB (31 studies) were as follows: sensitivity 0.82 (95% CI 0.81-0.83), specificity 0.99 (95% CI 0.99-0.99), positive likelihood ratio 43.00 (28.23-64.81), negative likelihood ratio 0.16 (0.12-0.20), diagnostic odds ratio 324.26 (95% CI 189.08-556.09) and area under curve 0.99. Summary estimates for extra-pulmonary TB (25 studies) were as follows: sensitivity 0.70 (95% CI 0.67-0.72), specificity 0.99 (95% CI 0.99-0.99), positive likelihood ratio 29.82 (17.86-49.78), negative likelihood ratio 0.33 (0.26-0.42), diagnostic odds ratio 125.20 (95% CI 65.75-238.36) and area under curve 0.96. RT-PCR assay demonstrated a high degree of sensitivity for pulmonary TB and good sensitivity for extra-pulmonary TB. It indicated a high degree of specificity for ruling in TB infection from sampling regimes. This was acceptable, but may better as a rule out add-on diagnostic test. RT-PCR assays demonstrate both a high degree of sensitivity in pulmonary samples and rapidity of detection of TB which is an important factor in achieving effective global control and for patient management in terms of initiating early and appropriate anti-tubercular therapy. PROSPERO CRD42015027534 .

Determinants of workplace violence against clinical physicians in hospitals.

PubMed

Wu, Jeng-Cheng; Tung, Tao-Hsin; Chen, Peter Y; Chen, Ying-Lin; Lin, Yu-Wen; Chen, Fu-Li

2015-01-01

Workplace violence in the health sector is a worldwide concern. Physicians play an essential role in health-care teamwork; thus, understanding how organizational factors influence workplace violence against physicians is critical. A total of 189 physicians from three public hospitals and one private hospital in Northern Taiwan completed a survey, and the response rate was 47.1%. This study was approved by the institutional review board of each participating hospital. The 189 physicians were selected from the Taipei area, Taiwan. The results showed that 41.5% of the respondents had received at least one workplace-related physical or verbal violent threat, and that 9.8% of the respondents had experienced at least one episode of sexual harassment in the 3 months before the survey. Logistic regression analysis revealed that physicians in psychiatry or emergency medicine departments received more violent threats and sexual harassment than physicians in other departments. Furthermore, physicians with a lower workplace safety climate (OR=0.89; 95% CI=0.81-0.98) and more job demands (OR=1.15; 95% CI=1.02-1.30) were more likely to receive violent threats. This study found that workplace violence was associated with job demands and the workplace safety climate. Therefore, determining how to develop a workplace safety climate and ensure a safe job environment for physicians is a crucial management policy issue for health-care systems.

Modular space station phase B extension period executive summary

NASA Technical Reports Server (NTRS)

Tischler, A. A.; Could, C. L.

1972-01-01

A narrative summary is presented of technical, programmatic, and planning information developed during the space station definition study extension period. The modular space station is emphasized, but tasks pertaining to shuttle sorties missions and information management advanced development are included. A series of program options considering technical, schedule, and programmatic alternatives to the baseline program are defined and evaluated.

Analysis of Human Resource Development and Utilization in Nigeria, Summary and Conclusions.

ERIC Educational Resources Information Center

Education and World Affairs, New York, NY.

This report is a second synthesis of the observations and recommendations of the Education and Human Resource Development Committee's Nigerian Project Task Force, which have been in the process of formulation since early 1965. A summary report, this paper does not include substantiation of all points: it is meant to present an overview of the Task…

Marine Corps Maneuver Squad Leader Mastery Model

DTIC Science & Technology

2012-12-17

developed a set of five competencies (sensemaking, adaptability, problem solving,  metacognition , and attentional control) and ten enabling cognitive and... metacognition ,  and  attentional  control)  and  the  ten  CARS  (cognitive  flexibility,  resilience,  anomaly  detection, change detection...practice  and  education.  Bulletin  of  Science,  Technology   &  Society, 24(3), 189‐199.  Bennett, M. J. (1993). Towards Ethnorelativism: A

Incidence and Outcomes of Inferior Vena Cava Filter Thrombus during Catheter-directed Thrombolysis for Proximal Deep Venous Thrombosis.

PubMed

Jiang, Jianguang; Tu, Jianfei; Jia, Zhongzhi; Chen, Jiezhong; Cao, Haitao; Meng, Qingli; Fuller, Tyler A; Tian, Feng

2017-01-01

The aim of the study was to retrospectively evaluate the incidence and outcomes of inferior vena cava (IVC) filter thrombus during catheter-directed thrombolysis (CDT) for acute proximal deep venous thrombosis (DVT). From October 2006 to June 2015, patients diagnosed with acute proximal DVT and received CDT after a retrievable IVC filter was placed were included. The incidence, treatment, and outcomes of IVC filter thrombus during CDT were recorded and analyzed. A total of 189 patients (91 women, 98 men; mean age, 57.6 ± 9.8 years; range, 24-85 years) were included in this study. Among the 189 cases, the DVTs involved popliteal iliofemoral veins in 54 patients, iliofemoral veins in 113 patients, and iliac veins in 22 patients, of which 18 patients had thrombus extended into the IVC. Of the 189 patients, a total of 8 (4.2%, 8 of 189) patients were identified with IVC filter thrombus during CDT. The IVC filter thrombus was detected on a median of 2 days (range, 2-4 days) of CDT therapy, including small-size (n = 6) and large-size (n = 2) filter thrombus. Of the 8 patients, CDTs were performed with a mean 7.6 ± 1.1 days (range, 6-11 days) after the presence of symptoms for the treatment of proximal DVT, and all the IVC filter thrombi were lysed during CDT for the proximal DVT. All the IVC filters were removed successfully with a mean of 12.8 ± 0.93 days from placement. There were no procedure- or thrombolysis-related major complications, and no symptomatic pulmonary embolism breakthrough was seen in any of the patients after the filter placement. IVC filter thrombus during CDT for the acute proximal DVT is uncommon, and all of them did not need any additional treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

Generation of Natural-Language Textual Summaries from Longitudinal Clinical Records.

PubMed

Goldstein, Ayelet; Shahar, Yuval

2015-01-01

Physicians are required to interpret, abstract and present in free-text large amounts of clinical data in their daily tasks. This is especially true for chronic-disease domains, but holds also in other clinical domains. We have recently developed a prototype system, CliniText, which, given a time-oriented clinical database, and appropriate formal abstraction and summarization knowledge, combines the computational mechanisms of knowledge-based temporal data abstraction, textual summarization, abduction, and natural-language generation techniques, to generate an intelligent textual summary of longitudinal clinical data. We demonstrate our methodology, and the feasibility of providing a free-text summary of longitudinal electronic patient records, by generating summaries in two very different domains - Diabetes Management and Cardiothoracic surgery. In particular, we explain the process of generating a discharge summary of a patient who had undergone a Coronary Artery Bypass Graft operation, and a brief summary of the treatment of a diabetes patient for five years.

MEASUREMENT OF THE CROSS-SECTION FOR THE γ γ -> p/line{p} PROCESS AT √ {s} = 183 - 189\\ GeV AT LEP

NASA Astrophysics Data System (ADS)

Barillari, T.

2002-07-01

The OPAL detector at LEP has been used to study the exclusive production of proton antiproton pairs in the collisions of two quasi-real photons using data taken at √ {s} = 183\\ GeV and 189 GeV. The results here presented are for γγ invariant masses, W, in the range 2.15 GeV < W < 3.95 GeV. The cross-section measurements are compared with previous data and with recent analytic calculations based on the quark-diquark model predictions.

Legionella pollution in cooling tower water of air-conditioning systems in Shanghai, China.

PubMed

Lin, H; Xu, B; Chen, Y; Wang, W

2009-02-01

To determine Legionella pollution prevalence, describe the amount of Legionellae with respect to temperature in Shanghai cooling tower water (CTWs) in various types of public sites. Six urban districts were selected as the study fields, adopting multiple-phase sampling methods. Routine culture was used to identify Legionellae. Of the samples, 58.9% (189/321) were observed to be positive, 19.9% were isolated over 100 CFU ml(-1). Legionella pneumophila serogroup 1 was the most frequently isolated species (155/189, 82.0%), followed by Leg. micdadei that was at the second place (44/189, 23.3%). The mean CFU ml(-1) of Legionellae in CTWs reached its peak from July to September. Over all 15.4% of the samples exceeding 100 CFU ml(-1) were observed in a hospital setting. The prevalence of Legionella pollution in CTWs, especially in CTWs of subway stations and hospitals, is worrying, and the positive rate and CFU ml(-1) of Legionellae in CTWs have a close relationship with air temperature. The study demonstrates pollution prevalence rates in different types of sites and various seasons, and provides a proportion of different serogroups of Legionellae. It illuminates an urgent need for dealing with the potential risk of legionellosis in Shanghai, through improved control and prevention strategies.

Resource management and operations in central North Dakota: Climate change scenario planning workshop summary November 12-13, 2015, Bismarck, ND

USGS Publications Warehouse

Fisichelli, Nicholas A.; Schuurman, Gregor; Symstad, Amy J.; Ray, Andrea; Friedman, Jonathan M.; Miller, Brian; Rowland, Erika

2016-01-01

The Scaling Climate Change Adaptation in the Northern Great Plains through Regional Climate Summaries and Local Qualitative-Quantitative Scenario Planning Workshops project synthesizes climate data into 3-5 distinct but plausible climate summaries for the northern Great Plains region; crafts quantitative summaries of these climate futures for two focal areas; and applies these local summaries by developing climate-resource-management scenarios through participatory workshops and, where possible, simulation models. The two focal areas are central North Dakota and southwest South Dakota (Figure 1). The primary objective of this project is to help resource managers and scientists in a focal area use scenario planning to make management and planning decisions based on assessments of critical future uncertainties.This report summarizes project work for public and tribal lands in the central North Dakota focal area, with an emphasis on Knife River Indian Villages National Historic Site. The report explainsscenario planning as an adaptation tool in general, then describes how it was applied to the central North Dakota focal area in three phases. Priority resource management and climate uncertainties were identified in the orientation phase. Local climate summaries for relevant, divergent, and challenging climate scenarios were developed in the second phase. In the final phase, a two-day scenario planning workshop held November 12-13, 2015 in Bismarck, ND, featured scenario development and implications, testing management decisions, and methods for operationalizing scenario planning outcomes.

Resource management and operations in southwest South Dakota: Climate change scenario planning workshop summary January 20-21, 2016, Rapid City, SD

USGS Publications Warehouse

Fisichelli, Nicholas A.; Schuurman, Gregor W.; Symstad, Amy J.; Ray, Andrea; Miller, Brian; Cross, Molly; Rowland, Erika

2016-01-01

The Scaling Climate Change Adaptation in the Northern Great Plains through Regional Climate Summaries and Local Qualitative-Quantitative Scenario Planning Workshops project synthesizes climate data into 3-5 distinct but plausible climate summaries for the northern Great Plains region; crafts quantitative summaries of these climate futures for two focal areas; and applies these local summaries by developing climate-resource-management scenarios through participatory workshops and, where possible, simulation models. The two focal areas are central North Dakota and southwest South Dakota (Figure 1). The primary objective of this project is to help resource managers and scientists in a focal area use scenario planning to make management and planning decisions based on assessments of critical future uncertainties.This report summarizes project work for public and tribal lands in the southwest South Dakota grasslands focal area, with an emphasis on Badlands National Park and Buffalo Gap National Grassland. The report explains scenario planning as an adaptation tool in general, then describes how it was applied to the focal area in three phases. Priority resource management and climate uncertainties were identified in the orientation phase. Local climate summaries for relevant, divergent, and challenging climate scenarios were developed in the second phase. In the final phase, a two-day scenario planning workshop held January 20-21, 2016 in Rapid City, South Dakota, featured scenario development and implications, testing management decisions, and methods for operationalizing scenario planning outcomes.

45 CFR 1303.12 - Summary suspension and opportunity to show cause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Summary suspension and opportunity to show cause... HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN... PROSPECTIVE DELEGATE AGENCIES Appeals by Grantees § 1303.12 Summary suspension and opportunity to show cause...

Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kB-dependent signaling

PubMed Central

Castri, Paola; Lee, Yang-ja; Ponzio, Todd; Maric, Dragan; Spatz, Maria; Bembry, Joliet; Hallenbeck, John

2014-01-01

Poly(ADP-ribose) polymerase-1 (PARP-1) and its cleavage products regulate cell viability and NF-kB activity when expressed in neurons. PARP-1 cleavage generates a 24kDa (PARP-124) and an 89kDa fragment (PARP-189). Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1UNCL) or of PARP-124 conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-189 was cytotoxic. Viability experiments were performed in SH-SY5Y, a human neuroblastoma cell line, as well as in rat primary cortical neurons. Following OGD, the higher viability in the presence of PARP-1UNCL or PARP-124 was not accompanied with decreased formation of poly(ADP-riboses) or higher NAD levels. PARP-1 is a known cofactor for NF-kB, hence we investigated whether PARP-1 cleavage influences the inflammatory response. All PARP-1 constructs mimicked PARP-1WT in regards to induction of NF-kB translocation into the nucleus and its increased activation during ischemic challenge. However, expression of PARP-189 construct induced significantly higher NF-kB activity than PARP-1WT; and the same was true for NF-kB-dependent iNOS promoter binding activity. At a protein level, PARP-1UNCL and PARP-124 decreased iNOS (and lower levels of iNOS transcript) and COX-2, and increased Bcl-xL. The increased levels of NF-kB and iNOS transcriptional activities, seen with cytotoxic PARP-189, were accompanied by higher protein expression of COX-2 and iNOS (and higher levels of iNOS transcript) and lower protein expression of Bcl-xL. Taken together, these findings suggest that PARP-1 cleavage products may regulate cellular viability and inflammatory responses in opposing ways during in vitro models of “ischemia”. PMID:24333653

Virtual patients to explore and develop clinical case summary statement skills amongst Japanese resident physicians: a mixed methods study.

PubMed

Heist, Brian S; Kishida, Naoki; Deshpande, Gautam; Hamaguchi, Sugihiro; Kobayashi, Hiroyuki

2016-02-01

In Western clinical training, formulation of a summary statement (SS) is a core exercise for articulation, evaluation, and improvement of clinical reasoning (CR). In Japanese clinical training, structured guidance in developing CR, including opportunity for SS practice, is uncommon, and the present status of case summarization skills is unclear. We used Virtual Patients (VPs) to explore Japanese junior residents' SS styles and the effectiveness of VPs on improving SS quality. All first-year junior resident physicians at 4 residency programs (n = 54) were assigned randomized sequences of 5 VP modules, rolled out at 6 day intervals. During each module, participants free-texted a case summary and then reviewed a model summary. Thematic analysis was used to identify SS styles and each SS was categorized accordingly. Frequency of SS styles, and SS CR quality determined by 1) an internally developed Key Feature rubric and 2) demonstration of semantic qualification, were compared across modules. Four SS styles were identified: numbered features matched to differential diagnoses, differential diagnoses with supportive comments, feature listing, and narrative summarization. From module #1 to #5, significant increases in the narrative summarization SS style (p = 0.016), SS CR quality score (p = 0.021) and percentage of semantically driven SS (p = 0.003) were observed. Our study of Japanese junior residents identified distinct clinical case summary statement styles, and observed adoption of the narrative summarization style and improvement in the CR quality of summary statements during a series of VP cases.

Major thermal springs of Utah

USGS Publications Warehouse

Mundorff, J.C.

1970-01-01

As part of a study of the springs of Utah, reconnaissance data were obtained on the thermal, chemical, and geologic characteristics of the major thermal springs or Utah. Only three of the springs have temperatures near the boiling point of water; the maximum recorded temperatures of these springs range from 185° to 189° F. All three springs are in or near areas of late Tertiary or Quaternary volcanism.Temperatures of the thermal springs studied ranged from 68° to 189° F. Nearly all thermal springs in Utah are in or near fault zones. Very few of these springs issue from volcanic rocks, but several springs are close to areas of late Tertiary or Quaternary volcanic rocks.

Poverty and development: pulling forces and the challenges for nursing in Africa.

PubMed

Klopper, Hester C

2007-12-01

In September 2000 the United Nations Millennium Declaration was adopted and endorsed by 189 countries, translating into eight Millennium Development Goals (MDGs) to be reached by 2015. At the midpoint between the MDG adoption in 2000 and the 2015 target date for achieving the goals, Sub-Saharan Africa (SSA) is not on track to achieve their MDGs. Poverty and development are pulling forces and impact on the ability to achieve the MDGs in SSA, thus the main purpose of this article is to participate in the debate concerning the global theme of poverty and development and the challenges for the nursing profession. In this article the concepts of poverty and development are explored, and the existing trends with specific reference to SSA are investigated. An evaluation of the present status of SSA in reaching the MDG's is examined and the article concludes with a discussion of the challenges for nursing in Africa.

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.

PubMed

Moosajee, Mariya; Gregory-Evans, Kevin; Ellis, Charles D; Seabra, Miguel C; Gregory-Evans, Cheryl Y

2008-12-15

The extensive molecular genetic heterogeneity seen with inherited eye disease is a major barrier to the development of gene-based therapeutics. The underlying molecular pathology in a considerable proportion of these diseases however are nonsense mutations leading to premature termination codons. A therapeutic intervention targeted at this abnormality would therefore potentially be relevant to a wide range of inherited eye diseases. We have taken advantage of the ability of aminoglycoside drugs to suppress such nonsense mutations and partially restore full-length, functional protein in a zebrafish model of choroideraemia (chm(ru848); juvenile chorio-retinal degeneration) and in two models of ocular coloboma (noi(tu29a) and gup(m189); congenital optic fissure closure defects). In vitro cell-based assays showed significant readthrough with two drugs, gentamicin and paromomycin, which was confirmed by western blot and in vitro prenylation assays. The presence of either aminoglycoside during zebrafish development in vivo showed remarkable prevention of mutant ocular phenotypes in each model and a reduction in multisystemic defects leading to a 1.5-1.7-fold increase in survival. We also identified a significant reduction in abnormal cell death shown by TUNEL assay. To test the hypothesis that optic fissure closure was apoptosis-dependent, the anti-apoptotic agents, curcumin and zVAD-fmk, were tested in gup(m189) embryos. Both drugs were found to reduce the size of the coloboma, providing molecular evidence that cell death is required for optic fissure remodelling. These findings draw attention to the value of zebrafish models of eye disease as useful preclinical drug screening tools in studies to identify molecular mechanisms amenable to therapeutic intervention.

1956 bibliography of Pacific Northwest forest soils publications.

Treesearch

Robert F. Tarrant

1957-01-01

In 1956, a summary of references on Pacific Northwest forest soils research was developed to begin a systematic annual recording of regionally published material in this comparatively new field. This summary included references for all years through 1955.

Design considerations for bridge deck joint-sealing systems : summary report.

DOT National Transportation Integrated Search

1992-07-01

This is a report summary which summarizes a three year research effort related to the study of bridge deck expansion joint movements. Bridge deck expansion joint systems often develop serious problems requiring extensive and expensive maintenance. Th...

Three dominant awnless genes in common wheat: Fine mapping, interaction and contribution to diversity in awn shape and length

PubMed Central

Ohno, Ryoko; Kimura, Tatsuro; Enoki, Hiroyuki; Nishimura, Satoru; Nasuda, Shuhei

2017-01-01

The awn is a long needle-like structure formed at the tip of the lemma in the florets of some grass species. It plays a role in seed dispersal and protection against animals, and can contribute to the photosynthetic activity of spikes. Three main dominant inhibitors of awn development (Hd, B1 and B2) are known in hexaploid wheat, but the causal genes have not been cloned yet and a genetic association with awn length diversity has been found only for the B1 allele. To analyze the prevalence of these three awning inhibitors, we attempted to predict the genotypes of 189 hexaploid wheat varieties collected worldwide using markers tightly linked to these loci. Using recombinant inbred lines derived from two common wheat cultivars, Chinese Spring and Mironovskaya 808, both with short awns, and a high-density linkage map, we performed quantitative trait locus analysis to identify tightly linked markers. Because this linkage map was constructed with abundant array-based markers, we converted the linked markers to PCR-based markers and determined the genotypes of 189 hexaploids. A significant genotype-phenotype correlation was observed at the Hd and B1 regions. We also found that interaction among these three awning inhibitors is involved in development of a membranous outgrowth at the base of awn resembling the Hooded mutants of barley. For the hooded awn phenotype, presence of the Hd dominant allele was essential but not sufficient, so B2 and other factors appear to act epistatically to produce the ectopic tissue. On the other hand, the dominant B1 allele acted as a suppressor of the hooded phenotype. These three awning inhibitors largely contribute to the genetic variation in awn length and shape of common wheat. PMID:28437453

Three dominant awnless genes in common wheat: Fine mapping, interaction and contribution to diversity in awn shape and length.

PubMed

Yoshioka, Motohiro; Iehisa, Julio C M; Ohno, Ryoko; Kimura, Tatsuro; Enoki, Hiroyuki; Nishimura, Satoru; Nasuda, Shuhei; Takumi, Shigeo

2017-01-01

The awn is a long needle-like structure formed at the tip of the lemma in the florets of some grass species. It plays a role in seed dispersal and protection against animals, and can contribute to the photosynthetic activity of spikes. Three main dominant inhibitors of awn development (Hd, B1 and B2) are known in hexaploid wheat, but the causal genes have not been cloned yet and a genetic association with awn length diversity has been found only for the B1 allele. To analyze the prevalence of these three awning inhibitors, we attempted to predict the genotypes of 189 hexaploid wheat varieties collected worldwide using markers tightly linked to these loci. Using recombinant inbred lines derived from two common wheat cultivars, Chinese Spring and Mironovskaya 808, both with short awns, and a high-density linkage map, we performed quantitative trait locus analysis to identify tightly linked markers. Because this linkage map was constructed with abundant array-based markers, we converted the linked markers to PCR-based markers and determined the genotypes of 189 hexaploids. A significant genotype-phenotype correlation was observed at the Hd and B1 regions. We also found that interaction among these three awning inhibitors is involved in development of a membranous outgrowth at the base of awn resembling the Hooded mutants of barley. For the hooded awn phenotype, presence of the Hd dominant allele was essential but not sufficient, so B2 and other factors appear to act epistatically to produce the ectopic tissue. On the other hand, the dominant B1 allele acted as a suppressor of the hooded phenotype. These three awning inhibitors largely contribute to the genetic variation in awn length and shape of common wheat.

Screening Ultrasound as an Adjunct to Mammography in Women with Mammographically Dense Breasts

PubMed Central

Scheel, John R.; Lee, Janie M.; Sprague, Brian L.; Lee, Christoph I.; Lehman, Constance D.

2015-01-01

There is increasing interest in the potential benefits and harms of screening ultrasound to supplement mammographic screening of women with dense breast tissue. We review the current evidence regarding adjunctive screening breast ultrasound (US) and provide a summary for clinicians who counsel patients with dense breasts. We conducted a comprehensive literature review of published clinical trials and observational cohort studies assessing the efficacy of screening handheld US (HHUS) and automated breast US (ABUS) to supplement mammography among women with dense breasts. From a total of 189 peer-reviewed publications on the performance of screening US, 12 studies were relevant to our analysis. The reporting of breast cancer risk factors varied across studies; however, the study populations tended to be at greater than average risk for developing breast cancer. There is consistent evidence that adjunctive screening US detects more invasive cancers compared to mammography alone, but there is currently no evidence of associated long-term breast cancer mortality reduction. The studies also collectively found that US was associated with an additional 11.7–106.6 biopsies/1,000 examinations (Median 52.2), and detected an additional 0.3–7.7 cancers/1,000 examinations (Median 4.2). The associated number of unnecessary breast biopsies resulting from adjunct US screening exceeds that observed with screening mammography alone by approximately 5-fold. Adjunctive screening with ultrasound should also be considered in the context of screening mammography. It is important for clinicians to be aware that improvements in cancer detection in mammographically dense breasts have been achieved with the transition from film to digital mammography, reducing a limitation of film mammography. Clinicians should discuss breast density as one of several important breast cancer risk factors, consider the potential harms of adjunctive screening, and arrive at a shared decision consistent with each woman’s preferences and values. PMID:24959654

The Development of Performance-Based Auditory Aviation Classification Standards in the U.S. Navy,

DTIC Science & Technology

1987-12-01

Gerontology, Vol. 24(2), pp. 189-192, 1969. 10. Palva, A. and Jokinen, K., ’The Role of the Binaural Test in Filtered Speech Audiometry." Acta Oto...BEAD BEAT BEAN REEL HEEL EEL PAVE PALE PAY WIG RIG FIG GALE MALE TALE PAGE PANE PACE PIG BIG DIG PALE SALE BALE DID DIN DIP SAP SAG SAD SIN WIN...SEEN SEED SEEK CAME GAME SAME NEAT BEAT SEAT SEEM SEETHE SEEP PAD PASS PATH PARK MARK HARK SIP RIP TIP PACK PAN PAT DARK LARK BARK LIP HIP DIP LED

Association Between Genes Involved in Craniofacial Development and Nonsyndromic Cleft Lip and/or Palate in the Brazilian Population.

PubMed

Machado, Renato Assis; Messetti, Ana Camila; de Aquino, Sibele Nascimento; Martelli-Júnior, Hercílio; Swerts, Mário Sérgio Oliveira; de Almeida Reis, Silvia Regina; Moreira, Helenara Salvati Bertolossi; Persuhn, Darlene Camati; Coletta, Ricardo D

2016-09-01

To determine the association of single-nucleotide polymorphisms (SNPs) in genes related to craniofacial development, which were previously identified as susceptibility signals for nonsyndromic oral clefts, in Brazilians with nonsyndromic cleft lip and/or palate (NSCL/P). The SNPs rs748044 (TNP1), rs1106514 (MSX1), rs28372960, rs15251 and rs2569062 (TCOF1), rs7829058 (FGFR1), rs1793949 (COL2A1), rs11653738 (WNT3), and rs242082 (TIMP3) were assessed in a family-based transmission disequilibrium test (TDT) and a structured case-control analysis based on the individual ancestry proportions. The SNPs were initially analyzed by TDT, and polymorphisms showing a trend toward excess transmission were subsequently studied in an independent case-control sample. The study sample consisted of 189 case-parent trios of nonsyndromic cleft lip with or without cleft palate (NSCL±P), 107 case-parent trios of nonsyndromic cleft palate (NSCP), 318 isolated samples of NSCL±P, 189 isolated samples of NSCP, and 599 healthy controls. Association of alleles with NSCL/P pathogenesis. Preferential transmission of SNPs rs28372960 and rs7829058 in NSCL±P trios and rs11653738 in NSCP trios (P = .04) were observed, although the structured case-control analysis did not confirm these associations. The haplotype T-C-C formed by TCOF1 SNPs rs28372960, rs15251, and rs2569062 was more frequently transmitted from healthy parents to NSCL±P offspring, but the P value (P = .01) did not withstand Bonferroni correction for multiple tests. With the modest associations, our results do not support the hypothesis that TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3, and TIMP3 variants are risk factors for nonsyndromic oral clefts in the Brazilian population.

An Analysis of the Evolution of Government Patent Policy in Research and Development Contracts.

DTIC Science & Technology

1981-03-01

LAW AMENDMENTS OF 1980 ------- 94 G. SUMMARY 98 VI . CONCLUSIONS AND RECOMMENDATIONS 100 A. GENERAL --- 100 B. SUMMARY ----- 100 C. CONCLUSIONS 103 D...Note: Appendix D contains a complete text of the 1980 amendments, Public Law 96-517. Chapter VI provides a summary to the evolution of Government...to but a small percentage of Federal R & D contracts. 99 VI . CONCLUSIONS AND RECOMMENDATIONS A. GENERAL This chapter is divided into three sections

Mechanistic-empirical design, implementation, and monitoring for flexible pavements : a project summary.

DOT National Transportation Integrated Search

2014-05-01

This document is a summary of tasks performed for Project ICT-R27-060. : Mechanistic-empirical (M-E)based flexible pavement design concepts and procedures were : developed in previous Illinois Cooperative Highway Research Program projects (IHR-510...

Stirling Space Engine Program. Volume 2; Appendixes A, B, C and D

NASA Technical Reports Server (NTRS)

Dhar, Manmohan

1999-01-01

The objective of this program was to develop the technology necessary for operating Stirling power converters in a space environment and to demonstrate this technology in full-scale engine tests. Volume 2 of the report includes the following appendices: Appendix A: Heater Head Development (Starfish Heater Head Program, 1/10th Segment and Full-Scale Heat Pipes, and Sodium Filling and Processing); Appendix B: Component Test Power Converter (CTPC) Component Development (High-temperature Organic Materials, Heat Exchanger Fabrication, Beryllium Issues, Sodium Issues, Wear Couple Tests, Pressure Boundary Penetrations, Heating System Heaters, and Cooler Flow Test); Appendix C: Udimet Testing (Selection of the Reference Material for the Space Stirling Engine Heater Head, Udimet 720LI Creep Test Result Update, Final Summary of Space Stirling Endurance Engine Udimet 720L1 Fatigue Testing Results, Udimet 720l1 Weld Development Summary, and Udimet 720L1 Creep Test Final Results Summary), and Appendix D: CTPC Component Development Photos.

Biodegradation of DIMP, Dieldrin, Isodrin, DBCP, and PCPMSO in Rocky Mountain Arsenal Soils. Installation Restoration Program, Environmental Technology Development

DTIC Science & Technology

1989-01-01

Number DAAK- 1 1 -85-D-007 Report Number CETHA-TE-CR-89006 January 1989 Prepared for: COMMANDER, U.S. ARMY TOXIC AND HAZARDOUS MATERIALS AGENCY Aberdeen...UNIT Aberdeen Proving Ground, MD 21010-5401 ELEMENT NO. NO. NO. ACCESSION NO. 1 . TITLE (Include Security Classification) - Biodegradation of DIMP...TYPE OF REPORT 113b. TIME COVERED 114. DATE OF REPORT (Year, Month, Day) 15. PAGE COUNT Final I FROM 1 /87 TO_1/89 1989 January 30 6. SUPPLEMENTARY

Executive Information Systems for Providing Next Generation Strategic Information: An Evaluation of EIS (Executive Information System) Software and Recommended Applicability within the FAA Computing Environment

DTIC Science & Technology

1989-01-01

the FAA Computing Environment 7. Author(s) S. Performing Organization Report No. MT/O1-89. Al 9. Performing Organization Name and Address 10. Work Unit...him in advance by analysts and developers -- an electronic3 version of the Performance Indicators report. Ease of Use. pcEXPRESS has an automatic link...overcome within the required timeframe. I These advanced features of the EXPRESS system allow the fastest possible response to changing executive information

Mechanics of Ballast Compaction. Volume 5 : Summary Report.

DOT National Transportation Integrated Search

1982-03-01

This report summarizes the results of research on the mechanics of ballast compaction. Details are provided in four preceeding reports. The scope of this summary includes: (1) a description of ballast physical state, (2) methods developed for measuri...

Project English Summaries, March 1970.

ERIC Educational Resources Information Center

Haughey, Charles F.; And Others

Information concerning Project English, which is being carried out at 14 universities and 1 State Department of Education through the support of the Office of Education, is provided in summary format. Project English is concerned with the development of English curriculum for Grades K through 12 and with the development of curriculum for…

Definition of technology development missions for early space station, orbit transfer vehicle servicing. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1983-01-01

Orbital Transfer Vehicle (OTV) servicing study scope, propellant transfer, storage and reliquefaction technology development missions (TDM), docking and berthing TDM, maintenance TDM, OTV/payload integration TDM, combined TDMS design, summary space station accomodations, programmatic analysis, and TDM equipment operational usage are discussed.

Comparison of Alternative Evidence Summary and Presentation Formats in Clinical Guideline Development: A Mixed-Method Study

PubMed Central

Opiyo, Newton; Shepperd, Sasha; Musila, Nyokabi; Allen, Elizabeth; Nyamai, Rachel; Fretheim, Atle; English, Mike

2013-01-01

Background Best formats for summarising and presenting evidence for use in clinical guideline development remain less well defined. We aimed to assess the effectiveness of different evidence summary formats to address this gap. Methods Healthcare professionals attending a one-week Kenyan, national guideline development workshop were randomly allocated to receive evidence packaged in three different formats: systematic reviews (SRs) alone, systematic reviews with summary-of-findings tables, and ‘graded-entry’ formats (a ‘front-end’ summary and a contextually framed narrative report plus the SR). The influence of format on the proportion of correct responses to key clinical questions, the primary outcome, was assessed using a written test. The secondary outcome was a composite endpoint, measured on a 5-point scale, of the clarity of presentation and ease of locating the quality of evidence for critical neonatal outcomes. Interviews conducted within two months following completion of trial data collection explored panel members’ views on the evidence summary formats and experiences with appraisal and use of research information. Results 65 (93%) of 70 participants completed questions on the prespecified outcome measures. There were no differences between groups in the odds of correct responses to key clinical questions. ‘Graded-entry’ formats were associated with a higher mean composite score for clarity and accessibility of information about the quality of evidence for critical neonatal outcomes compared to systematic reviews alone (adjusted mean difference 0.52, 95% CI 0.06 to 0.99). There was no difference in the mean composite score between SR with SoF tables and SR alone. Findings from interviews with 16 panelists indicated that short narrative evidence reports were preferred for the improved clarity of information presentation and ease of use. Conclusions Our findings suggest that ‘graded-entry’ evidence summary formats may improve clarity and accessibility of research evidence in clinical guideline development. Trial Registration Controlled-Trials.com ISRCTN05154264 PMID:23372813

NOAA's State Climate Summaries for the National Climate Assessment: A Sustained Assessment Product

NASA Astrophysics Data System (ADS)

Kunkel, K.; Champion, S.; Frankson, R.; Easterling, D. R.; Griffin, J.; Runkle, J. D.; Stevens, L. E.; Stewart, B. C.; Sun, L.; Veasey, S.

2016-12-01

A set of State Climate Summaries have been produced for all 50 U.S. states as part of the National Climate Assessment Sustained Assessment and represent a NOAA contribution to this process. Each summary includes information on observed and projected climate change conditions and impacts associated with future greenhouse gas emissions pathways. The summaries focus on the physical climate and coastal issues as a part of NOAA's mission. Core climate data and simulations used to produce these summaries have been previously published, and have been analyzed to represent a targeted synthesis of historical and plausible future climate conditions. As these are intended to be supplemental to major climate assessment development, the scope of the content remains true to a "summary" style document. Each state's Climate Summary includes its climatology and projections of future temperatures and precipitation, which are presented in order to provide a context for the assessment of future impacts. The climatological component focuses on temperature, precipitation, and noteworthy weather events specific to each state and relevant to the climate change discussion. Future climate scenarios are also briefly discussed, using well-known and consistent sets of climate model simulations based on two possible futures of greenhouse gas emissions. These future scenarios present an internally consistent climate picture for every state and are intended to inform the potential impacts of climate change. These 50 State Climate Summaries were produced by NOAA's National Centers for Environmental Information (NCEI) and the North Carolina State University Cooperative Institute for Climate and Satellites - NC (CICS-NC) with additional input provided by climate experts, including the NOAA Regional Climate Centers and State Climatologists. Each summary document also underwent a comprehensive and anonymous peer review. Each summary contains text, figures, and an interactive web presentation. A full suite of the comprehensive analyses and metadata are also available. The audience is targeted as both decision-makers and informed non-scientists. This presentation will discuss the scientific development for the project, demonstrate the suite of information, and provide examples of noteworthy figures from select states.

Construction and demolition waste indicators.

PubMed

Mália, Miguel; de Brito, Jorge; Pinheiro, Manuel Duarte; Bravo, Miguel

2013-03-01

The construction industry is one of the biggest and most active sectors of the European Union (EU), consuming more raw materials and energy than any other economic activity. Furthermore, construction waste is the commonest waste produced in the EU. Current EU legislation sets out to implement construction and demolition waste (CDW) prevention and recycling measures. However it lacks tools to accelerate the development of a sector as bound by tradition as the building industry. The main objective of the present study was to determine indicators to estimate the amount of CDW generated on site both globally and by waste stream. CDW generation was estimated for six specific sectors: new residential construction, new non-residential construction, residential demolition, non-residential demolition, residential refurbishment, and non-residential refurbishment. The data needed to develop the indicators was collected through an exhaustive survey of previous international studies. The indicators determined suggest that the average composition of waste generated on site is mostly concrete and ceramic materials. Specifically for new residential and new non-residential construction the production of concrete waste in buildings with a reinforced concrete structure lies between 17.8 and 32.9 kg m(-2) and between 18.3 and 40.1 kg m(-2), respectively. For the residential and non-residential demolition sectors the production of this waste stream in buildings with a reinforced concrete structure varies from 492 to 840 kg m(-2) and from 401 to 768 kg/m(-2), respectively. For the residential and non-residential refurbishment sectors the production of concrete waste in buildings lies between 18.9 and 45.9 kg/m(-2) and between 18.9 and 191.2 kg/m(-2), respectively.

Developing Conceptual Models for Assessing Climate Change Impacts to Contaminant Availability in Terrestrial Ecosystems

DTIC Science & Technology

2015-03-01

Stressors Secondary Source/ Stressors Measures of Effect Score Summary Individual Scores Compile Results Land Management (e.g., controlled fire ...Secondary Source/ Stressors Measures of Effect Score Summary Individual Scores Compile Results Land Management (e.g., controlled fire , timber...Greenberg 2005), effects of dredged material (PIANC 2006), and ecosystem restoration (Fischenich 2008) among others. The process of developing a conceptual

Summary of strategies for planning Productivity Improvement and Quality Enhancement (PIQE)

NASA Technical Reports Server (NTRS)

1986-01-01

The Summary of NASA Strategies for Productivity Improvement and Quality Enhancement respond to NASA's eighth top goal: Establish NASA as a leader in the development and application of advanced technology and management practices which contribute to significant increases in both Agency and national productivity. The Strategies provide the framework for development of the agency-wide Productivity Improvement and Quality Enhancement (PIQE) Plans.

Plain Language Summary: Adult Sinusitis (Sinus Infection).

PubMed

Caspersen, Leslie A; Walter, Lindsey M; Walsh, Sandra A; Rosenfeld, Richard M; Piccirillo, Jay F

2015-08-01

This plain language summary serves as an overview in explaining sinusitis (pronounced sign-you-side-tis). The purpose of this plain language summary is to provide patients with standard language explaining their condition in an easy-to-read format. This summary applies to those 18 years of age or older with sinusitis. The summary is featured as an FAQ (frequently asked question) format. The summary addresses how to manage and treat sinusitis symptoms. Adult sinusitis is often called a sinus infection. A healthcare provider may refer to a sinus infection as rhinosinusitis (pronounced rhi-no-sign-you-side-tis). This includes the nose as well as the sinuses in the name. A sinus infection is the swelling of the sinuses and nasal cavity.The summary is based on the published 2015 "Clinical Practice Guideline: Adult Sinusitis." The evidence-based guideline includes research to support more effective diagnosis and treatment of adult sinus infections. The guideline was developed as a quality improvement opportunity for managing sinus infections by creating clear recommendations to use in medical practice. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

Medical and social issues related to posttraumatic seizures in persons with traumatic brain injury.

PubMed

Bushnik, Tamara; Englander, Jeffrey; Duong, Thao

2004-01-01

The incidence of late posttraumatic seizures (LPTS) in individuals with traumatic brain injury (TBI) ranges anywhere from 5% to 18.9% in civilian populations up to 32% to 50% in military personnel. This article reviews the current knowledge about the incidence and prevalence of LPTS following a TBI, the risk factors for developing LPTS, and the options available for preventing the development of LPTS. The psychosocial ramifications of LPTS following a TBI have not been well explored. As a result, the psychosocial findings from the current literature on epilepsy will be reviewed with the hope that the need for future TBI outcomes research to investigate the impact of LPTS following a TBI or, at least, to include LPTS as a potential contributing factor will be recognized.

Fundamentals of Physics, Part 2 (Chapters 12-20)

NASA Astrophysics Data System (ADS)

Halliday, David; Resnick, Robert; Walker, Jearl

2003-12-01

Chapter 12 Equilibrium and Elasticity. What injury can occur to a rock climber hanging by a crimp hold? 12-1 What Is Physics? 12-2 Equilibrium. 12-3 The Requirements of Equilibrium. 12-4 The Center of Gravity. 12-5 Some Examples of Static Equilibrium. 12-6 Indeterminate Structures. 12-7 Elasticity. Review & Summary Questions Problems. Chapter 13 Gravitation. What lies at the center of our Milky Way galaxy? 13-1 What Is Physics? 13-2 Newton's Law of Gravitation. 13-3 Gravitation and the Principle of Superposition. 13-4 Gravitation Near Earth's Surface. 13-5 Gravitation Inside Earth. 13-6 Gravitational Potential Energy. 13-7 Planets and Satellites: Kepler's Laws. 13-8 Satellites: Orbits and Energy. 13-9 Einstein and Gravitation. Review & Summary Questions Problems. Chapter 14 Fluids. What causes ground effect in race car driving? 14-1 What Is Physics? 14-2 What Is a Fluid? 14-3 Density and Pressure. 14-4 Fluids at Rest. 14-5 Measuring Pressure. 14-6 Pascal's Principle. 14-7 Archimedes' Principle. 14-8 Ideal Fluids in Motion. 14-9 The Equation of Continuity. 14-10 Bernoulli's Equation. Review & SummaryQuestionsProblems. Chapter 15 Oscillations. What is the "secret" of a skilled diver's high catapult in springboard diving? 15-1 What Is Physics? 15-2 Simple Harmonic Motion. 15-3 The Force Law for Simple Harmonic Motion. 15-4 Energy in Simple Harmonic Motion. 15-5 An Angular Simple Harmonic Oscillator. 15-6 Pendulums. 15-7 Simple Harmonic Motion and Uniform Circular Motion. 15-8 Damped Simple Harmonic Motion. 15-9 Forced Oscillations and Resonance. Review & Summary Questions Problems. Chapter 16 Waves--I. How can a submarine wreck be located by distant seismic stations? 16-1 What Is Physics? 16-2 Types of Waves. 16-3 Transverse and Longitudinal Waves. 16-4 Wavelength and Frequency. 16-5 The Speed of a Traveling Wave. 16-6 Wave Speed on a Stretched String. 16-7 Energy and Power of a Wave Traveling Along a String. 16-8 The Wave Equation. 16-9 The Principle of Superposition for Waves. 16-10 Interference of Waves. 16-11 Phasors. 16-12 Standing Waves. 16-13 Standing Waves and Resonance. Review & Summary Questions Problems. Chapter 17 Waves--II. How can an emperor penguin .nd its mate among thousands of huddled penguins? 17-1 What Is Physics? 17-2 Sound Waves. 17-3 The Speed of Sound. 17-4 Traveling Sound Waves. 17-5 Interference. 17-6 Intensity and Sound Level. 17-7 Sources of Musical Sound. 17-8 Beats. 17-9 The Doppler Effect. 17-10 Supersonic Speeds, Shock Waves. Review & Summary Questions Problems. Chapter 18 Temperature, Heat, and the First Law of Thermodynamics. How can a dead rattlesnake detect and strike a reaching hand? 18-1 What Is Physics?. 18-2 Temperature. 18-3 The Zeroth Law of Thermodynamics. 18-4 Measuring Temperature. 18-5 The Celsius and Fahrenheit Scales. 18-6 Thermal Expansion. 18-7 Temperature and Heat. 18-8 The Absorption of Heat by Solids and Liquids. 18-9 A Closer Look at Heat and Work. 18-10 The First Law of Thermodynamics. 18-11 Some Special Cases of the First Law of Thermodynamics. 18-12 Heat Transfer Mechanisms. Review & Summary Questions Problems. Chapter 19 The Kinetic Theory of Gases. How can cooling steam inside a railroad tank car cause the car to be crushed? 19-1 What Is Physics? 19-2 Avogadro's Number. 19-3 Ideal Gases. 19-4 Pressure, Temperature, and RMS Speed. 19-5 Translational Kinetic Energy. 19-6 Mean Free Path. 19-7 The Distribution of Molecular Speeds. 19-8 The Molar Speci.c Heats of an Ideal Gas. 19-9 Degrees of Freedom and Molar Speci.c Heats. 19-10 A Hint of Quantum Theory. 19-11 The Adiabatic Expansion of an Ideal Gas. Review & Summary Questions Problems. Chapter 20 Entropy and the Second Law of Thermodynamics. Why is the popping of popcorn irreversible? 20-1 What Is Physics? 20-2 Irreversible Processes and Entropy. 20-3 Change in Entropy. 20-4 The Second Law of Thermodynamics. 20-5 Entropy in the Real World: Engines. 20-6 Entropy in the Real World: Refrigerators. 20-7 The Ef.ciencies of Real Engines. 20-8 A Statistical View of Entropy. Review & Summary Questions Problems. Appendices. A The International System of Units (SI). B Some Fundamental Constants of Physics. C Some Astronomical Data. D Conversion Factors. E Mathematical Formulas. F Properties of the Elements. G Periodic Table of the Elements. Answers to Checkpoints and Odd-Numbered Questions and Problems. Index.

PROMIS®-29 v2.0 profile physical and mental health summary scores.

PubMed

Hays, Ron D; Spritzer, Karen L; Schalet, Benjamin D; Cella, David

2018-03-22

The PROMIS-29 v2.0 profile assesses pain intensity using a single 0-10 numeric rating item and seven health domains (physical function, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, and sleep disturbance) using four items per domain. This paper describes the development of physical and mental health summary scores for the PROMIS-29 v2.0. We conducted factor analyses of PROMIS-29 scales on data collected from two internet panels (n = 3000 and 2000). Confirmatory factor analyses provided support for a physical health factor defined by physical function, pain (interference and intensity), and ability to participate in social roles and activities, and a mental health factor defined primarily by emotional distress (anxiety and depressive symptoms). Reliabilities for these two summary scores were 0.98 (physical health) and 0.97 (mental health). Correlations of the PROMIS-29 v2.0 physical and mental health summary scores with chronic conditions and other health-related quality of life measures were consistent with a priori hypotheses. This study develops and provides preliminary evidence supporting the reliability and validity of PROMIS-29 v2.0 physical and mental health summary scores that can be used in future studies to assess impacts of health care interventions and track changes in health over time. Further evaluation of these and alternative summary measures is recommended.

Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.

PubMed

Beauchet, Olivier; Annweiler, Cédric; Callisaya, Michele L; De Cock, Anne-Marie; Helbostad, Jorunn L; Kressig, Reto W; Srikanth, Velandai; Steinmetz, Jean-Paul; Blumen, Helena M; Verghese, Joe; Allali, Gilles

2016-06-01

Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms "Gait" OR "Gait Disorders, Neurologic" OR "Gait Apraxia" OR "Gait Ataxia" AND "Dementia" OR "Frontotemporal Dementia" OR "Dementia, Multi-Infarct" OR "Dementia, Vascular" OR "Alzheimer Disease" OR "Lewy Body Disease" OR "Frontotemporal Dementia With Motor Neuron Disease" (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P < .001 for any dementia, pooled HR = 1.79 with P < .001 for VaD, HR = 1.89 with P value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD. Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

Fractal pharmacokinetics of the drug mibefradil in the liver

NASA Astrophysics Data System (ADS)

Fuite, J.; Marsh, R.; Tuszyński, J.

2002-08-01

We explore the ramifications of the fractal geometry of the key organ for drug elimination, the liver, on pharmacokinetic data analysis. A formalism is developed for the use of a combination of well-stirred Euclidean and fractal compartments in the body. Perturbation analysis is carried out to obtain analytical solutions for the drug concentration time evolution. These results are then fitted to experimental data collected from clinically instrumented dogs [see, A. Skerjanec et al., J. Pharm. Sci. 85, 189 (1995)] using the drug mibefradil. The thus obtained spectral fractal dimension has a range of values that is consistent with the value found in independently performed ultrasound experiments on the liver.

Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin.

PubMed

Pozzi, Nicola; Zerbetto, Mirco; Acquasaliente, Laura; Tescari, Simone; Frezzato, Diego; Polimeno, Antonino; Gohara, David W; Di Cera, Enrico; De Filippis, Vincenzo

2016-07-19

Thrombin exists as an ensemble of active (E) and inactive (E*) conformations that differ in their accessibility to the active site. Here we show that redistribution of the E*-E equilibrium can be achieved by perturbing the electrostatic properties of the enzyme. Removal of the negative charge of the catalytic Asp102 or Asp189 in the primary specificity site destabilizes the E form and causes a shift in the 215-217 segment that compromises substrate entrance. Solution studies and existing structures of D102N document stabilization of the E* form. A new high-resolution structure of D189A also reveals the mutant in the collapsed E* form. These findings establish a new paradigm for the control of the E*-E equilibrium in the trypsin fold.

Mechanical features of the shuttle rotating service structure

NASA Technical Reports Server (NTRS)

Crump, J. M.

1985-01-01

With the development of the space shuttle launching facilities, it became mandatory to develop a shuttle rotating service structure to provide for the insertion and/or removal of payloads at the launch pads. The rotating service structure is a welded tubular steel space frame 189 feet high, 65 feet wide, and weighing 2100 tons. At the pivot column the structure is supported on a 30 inch diameter hemispherical bearing. At the opposite terminus the structure is supported on two truck assemblies each having eight 36 inch diameter double flanged wheels. The following features of the rotating service structure are discussed: (1) thermal expansion and contraction; (2) hurricane tie downs; (3) payload changeout room; (4) payload ground handling mechanism; (5) payload and orbiter access platforms; and (6) orbiter cargo bay access.

Medical imaging, PACS, and imaging informatics: retrospective.

PubMed

Huang, H K

2014-01-01

Historical reviews of PACS (picture archiving and communication system) and imaging informatics development from different points of view have been published in the past (Huang in Euro J Radiol 78:163-176, 2011; Lemke in Euro J Radiol 78:177-183, 2011; Inamura and Jong in Euro J Radiol 78:184-189, 2011). This retrospective attempts to look at the topic from a different angle by identifying certain basic medical imaging inventions in the 1960s and 1970s which had conceptually defined basic components of PACS guiding its course of development in the 1980s and 1990s, as well as subsequent imaging informatics research in the 2000s. In medical imaging, the emphasis was on the innovations at Georgetown University in Washington, DC, in the 1960s and 1970s. During the 1980s and 1990s, research and training support from US government agencies and public and private medical imaging manufacturers became available for training of young talents in biomedical physics and for developing the key components required for PACS development. In the 2000s, computer hardware and software as well as communication networks advanced by leaps and bounds, opening the door for medical imaging informatics to flourish. Because many key components required for the PACS operation were developed by the UCLA PACS Team and its collaborative partners in the 1980s, this presentation is centered on that aspect. During this period, substantial collaborative research efforts by many individual teams in the US and in Japan were highlighted. Credits are due particularly to the Pattern Recognition Laboratory at Georgetown University, and the computed radiography (CR) development at the Fuji Electric Corp. in collaboration with Stanford University in the 1970s; the Image Processing Laboratory at UCLA in the 1980s-1990s; as well as the early PACS development at the Hokkaido University, Sapporo, Japan, in the late 1970s, and film scanner and digital radiography developed by Konishiroku Photo Ind. Co. Ltd. (Konica-Minolta), Japan, in the 1980-1990s. Major support from the US National Institutes of Health and other federal agencies and private medical imaging industry are appreciated. The NATO (North Atlantic Treaty Organization) Advanced Study Institute (ASI) sponsored the International PACS Conference at Evian, France, in 1990, the contents and presentations of which convinced a half dozen high-level US military healthcare personnel, including surgeons and radiologists, that PACS was feasible and would greatly streamline the current military healthcare services. The impact of the post-conference summary by these individuals to their superiors opened the doors for long-term support of PACS development by the US Military Healthcare Services. PACS and imaging informatics have thus emerged as a daily clinical necessity.

Satellite power system: Concept development and evaluation program. Volume 3: Power transmission and reception. Technical summary and assessment

NASA Technical Reports Server (NTRS)

Dietz, R. H.; Arndt, G. D.; Seyl, J. W.; Leopold, L.; Kelley, J. S.

1981-01-01

Efforts in the DOE/NASA concept development and evaluation program are discussed for the solar power satellite power transmission and reception system. A technical summary is provided together with a summary of system assessment activities. System options and system definition drivers are described. Major system assessment activities were in support of the reference system definition, solid state system studies, critical technology supporting investigations, and various system and subsystem tradeoffs. These activities are described together with reference system updates and alternative concepts for each of the subsystem areas. Conclusions reached as a result of the numerous analytical and experimental evaluations are presented. Remaining issues for a possible follow-on program are identified.

Service Learning in the Middle School Curriculum: Supplement.

ERIC Educational Resources Information Center

Schukar, Ron; Singleton, Laurel; Parisi, Lynn

This supplement contains five unit summaries on service learning that were developed during the 1996 summer institutes conducted by the Social Science Education Consortium (SSEC) for teams of middle school teachers selected from the western United States. Each unit summary in the supplement has been developed to correspond in style to unit…

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

PubMed

Dai, D; Tang, J; Rose, R; Hodgson, E; Bienstock, R J; Mohrenweiser, H W; Goldstein, J A

2001-12-01

CYP3A4 is the most abundant isoform of cytochrome P450 (CYP) in adult human liver. It metabolizes numerous clinically, physiologically, and toxicologically important compounds. The expression of CYP3A4 varies 40-fold in individual human livers, and metabolism of CYP3A4 substrates varies at least 10-fold in vivo. Single nucleotide polymorphisms (SNPs) in CYP3A4 were identified by direct sequencing of genomic DNA in 72 individuals from three different ethnic groups, including Caucasians, Blacks (African-Americans and African pygmies), and Asians. A total of 28 SNPs were identified, including five which produced coding changes M445T (CYP3A4*3), R162Q (CYP3A4*15), F189S (CYP3A4*17), L293P (CYP3A4*18), and P467S (CYP3A4*19). The latter four represent new alleic variants. Racial variability was observed for the frequency of individual SNPs. CYP3A R162Q was identified only in Black populations with an allelic frequency of 4%. CYP3A4 F189S and CYP3A4 M445T were identified in Caucasians with allelic frequencies 2% and 4%, respectively. L293P and P467S were only observed in Asians at allelic frequencies of 2%. The cDNAs for the F189S, L293P, M445T, and P467S mutant alleles were constructed by site-directed mutagenesis and expressed in an Escherichia coli expression system. Testosterone and the insecticide chlorpyrifos were used to assess the catalytic activities of the most common CYP3A4 allele (CYP3A4*1) and its allelic variants. CYP3A4 F189S exhibited lower turnover numbers for testosterone and chlorpyrifos, while CYP3A4 L293P had higher turnover numbers for both substrates. The turnover numbers of the CYP3A4 M445T and P467S alleles to metabolize these compounds were not significantly different from those of wild-type CYP3A4.

Acute Toxicity Grade 3 and 4 After Irradiation in Children and Adolescents: Results From the IPPARCA Collaboration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pixberg, Caroline; Koch, Raphael; Eich, Hans Theodor, E-mail: Hans.Eich@ukmuenster.de

Purpose: In the context of oncologic therapy for children, radiation therapy is frequently indicated. This study identified the frequency of and reasons for the development of high-grade acute toxicity and possible sequelae. Materials and Methods: Irradiated children have been prospectively documented since 2001 in the Registry for the Evaluation of Side Effects After Radiation in Childhood and Adolescence (RiSK) database in Germany and since 2008 in the registry for radiation therapy toxicity (RADTOX) in Sweden. Data were collected using standardized, published forms. Toxicity classification was based on Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Results: Asmore » of June 2013, 1500 children have been recruited into the RiSK database and 485 into the RADTOX registry leading to an analysis population of 1359 patients (age range 0-18). A total of 18.9% (n=257) of all investigated patients developed high-grade acute toxicity (grades 3/4). High-grade toxicity of the bone marrow was documented for 63.8% (n=201) of those patients, oral mucositis for 7.6% (n=24), and dermatitis for 7.6% (n=24). Patients with high-grade acute toxicity received concomitant chemotherapy more frequently (56%) than patients with no or lower acute toxicity (31.5%). In multivariate analyses, concomitant chemotherapy, diagnosis of Ewing sarcoma, and total radiation dose showed a statistically noticeable effect (P≤.05) on acute toxicity, whereas age, concomitant chemotherapy, Hodgkin lymphoma, Ewing sarcoma, total radiation dose, and acute toxicity influenced the time until maximal late toxicity. Conclusions: Generally, high-grade acute toxicity after irradiation in children and adolescence occurs in a moderate proportion of patients (18.9%). As anticipated, the probability of acute toxicity appeared to depend on the prescribed dose as well as concomitant chemotherapy. The occurrence of chronic toxicity correlates with the prior acute toxicity grade. Age seems to influence the time until maximal late toxicity but not the development of acute toxicity.« less