Modifying homes for persons with physical disabilities in Thailand.

PubMed

Tongsiri, Sirinart; Ploylearmsang, Chanuttha; Hawsutisima, Katanyu; Riewpaiboon, Wachara; Tangcharoensathien, Viroj

2017-02-01

Thailand passed the Persons with Disabilities Empowerment Act in 2007. The Act, which is in compliance with the United Nations Convention on the Rights of Persons with Disabilities , ensures that registered persons with disabilities are entitled to home environment modifications' benefits up to a maximum of 20 000 baht (670 United States dollars); however, the Act's enforcement is still weak in Thailand. In 2013, researchers developed a home modification programme, consisting of a multidisciplinary team of medical and nonmedical practitioners and volunteers, to modify homes for persons with disabilities. The programme recruited participants with physical disabilities and assessed their functioning difficulties. Participants' homes were modified to address identified functioning difficulties. The project was implemented in four provinces in collaboration with staff from 27 district hospitals located in north-eastern Thailand. After the home modifications, all 43 recruited participants reported reduced difficulties in all areas, except for participants with severe degrees of difficulties, such as those reporting being unable to walk and unable to get up from the floor. The participants' quality of life had also improved. The average EQ-5D-5L score, measuring quality of life, increased by 0.203 - from 0.346 at baseline to 0.549 after the modifications. Home modifications in low-resourced settings are technically and financially feasible and can lead to reducing functioning difficulties and improving the quality of life of persons with disabilities. Implementation requires government subsidies to finance home modifications and the availability of technical guidelines and training on home modifications for implementing agents.

The computational nature of memory modification.

PubMed

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-03-15

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature.

Conserving Our Energy. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 11.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P9 SIS unit deals with: (1) the importance of energy in students' everyday lives; (2) energy forms and…

Living Things Reproduce. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 6.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P8 SIS unit focuses on reproduction in animals and in flowering plants. Particular topics examined include the…

Conserving Our Health. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 12.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P9 SIS unit deals with conserving health, focusing on such body processes as breathing, digestion, excretion,…

Conserving Our Environment. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 13.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P9 SIS unit focuses on: (1) basic ecological and conservation concepts; (2) problems and complexities of…

Water. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 3.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P7 SIS unit focuses on: (1) the importance of water in students' daily lives; (2) the need to purify drinking…

78 FR 45597 - Modification of the Harmonized Tariff Schedule of the United States for Certain Cheeses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE Modification of the Harmonized Tariff Schedule of the United States for Certain Cheeses AGENCY: Office of the United States Trade Representative. ACTION... and Romania in the EU-27, the tariff-rate quota (TRQ) allocations for certain cheeses from the EU-25...

Requirements to the procedure and stages of innovative fuel development

NASA Astrophysics Data System (ADS)

Troyanov, V.; Zabudko, L.; Grachyov, A.; Zhdanova, O.

2016-04-01

According to the accepted current understanding under the nuclear fuel we will consider the assembled active zone unit (Fuel assembly) with its structural elements, fuel rods, pellet column, structural materials of fuel rods and fuel assemblies. The licensing process includes justification of safe application of the proposed modifications, including design-basis and experimental justification of the modified items under normal operating conditions and in violation of normal conditions, including accidents as well. Besides the justification of modified units itself, it is required to show the influence of modifications on the performance and safety of the other Reactor Unit’ and Nuclear Plant’ elements (e.g. burst can detection system, transportation and processing operations during fuel handling), as well as to justify the new standards of fuel storage etc. Finally, the modified fuel should comply with the applicable regulations, which often becomes a very difficult task, if only because those regulations, such as the NP-082-07, are not covered modification issues. Making amendments into regulations can be considered as the only solution, but the process is complicated and requires deep grounds for amendments. Some aspects of licensing new nuclear fuel are considered the example of mixed nitride uranium -plutonium fuel application for the BREST reactor unit.

Air and Weather Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 2.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P7 SIS unit focuses on: (1) the importance of air and air pressure in students' everyday lives; (2) oxidation…

Techniques and Measurements. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 1.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P7 SIS unit is designed to: (1) introduce students to and familiarize them with working in the school laboratory;…

Magnets and Electricity. Seychelles Integrated Science [Teacher and Pupil Booklets]. Unit 8.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P8 SIS unit focuses on: (1) elementary concepts in magnetic theory and the role magnets and magnetism play in…

Acids and Alkalis. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 9.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P8 SIS unit focuses on: (1) the uses of acids and bases (alkalis) in students' everyday lives, stressing their…

Heat and Molecules. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 10.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P8 SIS unit deals with: (1) changes in temperature which make matter expand and contract (and how this affects…

The computational nature of memory modification

PubMed Central

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-01-01

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature. DOI: http://dx.doi.org/10.7554/eLife.23763.001 PMID:28294944

Gas and water recycling system for IOC vivarium experiments

NASA Technical Reports Server (NTRS)

Nitta, K.; Otsubo, K.

1986-01-01

Water and gas recycling units designed as one of the common experiment support system for the life science experiment facilities used in the Japanese Experiment Module are discussed. These units will save transportation and operation costs for the life science experiments in the space station. These units are also designed to have interfaces so simple that the connection to another life science experiment facilities such as the Research Animal Holding Facility developed by the Rockheed Missiles and Space Company can be easily done with small modification.

International transferability of accident modification functions for horizontal curves.

PubMed

Elvik, Rune

2013-10-01

Studies of the relationship between characteristics of horizontal curves and accident rate have been reported in several countries. The characteristic most often studied is the radius of a horizontal curve. Functions describing the relationship between the radius of horizontal curves and accident rate have been developed in Australia, Canada, Denmark, Germany, Great Britain, New Zealand, Norway, Portugal, Sweden, and the United States. Other characteristics of horizontal curves that have been studied include deflection angle, curve length, the presence of transition curves, super-elevation in curves and distance to adjacent curves. This paper assesses the international transferability of mathematical functions (accident modification functions) that have been developed to relate the radius of horizontal curves to their accident rate. The main research problem is whether these functions are similar, which enhances international transferability, or dissimilar, which reduces international transferability. Accident modification functions for horizontal curve radius developed in the countries listed above are synthesised. The sensitivity of the functions to other characteristics of curves than radius is examined. Accident modification functions developed in different countries have important similarities. The functions diverge with respect to accident rate in the sharpest curves. Copyright © 2013 Elsevier Ltd. All rights reserved.

Development of a Low Cost Graphics Terminal.

ERIC Educational Resources Information Center

Lehr, Ted

1985-01-01

Describes modifications made to expand the capabilities of a display unit (Lear Siegler ADM-3A) to include medium resolution graphics. The modifying circuitry is detailed along with software subroutined written in Z-80 machine language for controlling the video display. (JN)

Addendum to the Closure Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

2008-10-01

This document constitutes an addendum to the July 2003, Closure Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications.

Soil and Living Things. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 4.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P7 SIS unit focuses on: (1) the structure of the two main soil types in Seychelles; (2) the role of roots in…

Interlanguage Pragmatic Development: Internal and External Modification in L2 Arabic Requests

ERIC Educational Resources Information Center

Al Masaeed, Khaled

2017-01-01

This study investigated the way in which American university students learning Arabic as a foreign language in the United States developed the ability to make and modify requests both internally, through an addition of mitigating or aggravating modality markers, and externally, via supportive moves before or after the main request in formal and…

Use of SSDs in the USA – endangered species and water quality criteria

EPA Science Inventory

Species sensitivity distributions (SSDs) are used in the United States (US) in the development of national ambient water quality criteria (AWQC), with site-specific and numeric modifications to protect sensitive taxa including threatened and endangered species. The US Environment...

Orbiter Auxiliary Power Unit Flight Support Plan

NASA Technical Reports Server (NTRS)

Guirl, Robert; Munroe, James; Scott, Walter

1990-01-01

This paper discussed the development of an integrated Orbiter Auxiliary Power Unit (APU) and Improved APU (IAPU) Flight Suuport Plan. The plan identifies hardware requirements for continued support of flight activities for the Space Shuttle Orbiter fleet. Each Orbiter vehicle has three APUs that provide power to the hydraulic system for flight control surface actuation, engine gimbaling, landing gear deployment, braking, and steering. The APUs contain hardware that has been found over the course of development and flight history to have operating time and on-vehicle exposure time limits. These APUs will be replaced by IAPUs with enhanced operating lives on a vehicle-by-vehicle basis during scheduled Orbiter modification periods. This Flight Support Plan is used by program management, engineering, logistics, contracts, and procurement groups to establish optimum use of available hardware and replacement quantities and delivery requirements for APUs until vehicle modifications and incorporation of IAPUs. Changes to the flight manifest and program delays are evaluated relative to their impact on hardware availability.

Novel Galvanic Corrosion Inhibitors: Synthesis, Characterization, Fabrication and Testing

DTIC Science & Technology

2007-09-30

have attempted to develop methods based on chemical structural modification to prevent galvanically-induced composite corrosion. [9, 10-12] These...of the two metallopolymers 11 and 12 show characteristic MLCT (metal-to-ligand charge transfer) absorption band of tris(bipyridyl)Ru(II) unit at k...showed absorption band at 450 nm and emission band at 325 nm of tris(bipyridyl)Ru(II) units in its respective UV-vis and fluorescence spectra. Very

Modifying homes for persons with physical disabilities in Thailand

PubMed Central

Ploylearmsang, Chanuttha; Hawsutisima, Katanyu; Riewpaiboon, Wachara; Tangcharoensathien, Viroj

2017-01-01

Abstract Problem Thailand passed the Persons with Disabilities Empowerment Act in 2007. The Act, which is in compliance with the United Nations Convention on the Rights of Persons with Disabilities, ensures that registered persons with disabilities are entitled to home environment modifications’ benefits up to a maximum of 20 000 baht (670 United States dollars); however, the Act’s enforcement is still weak in Thailand. Approach In 2013, researchers developed a home modification programme, consisting of a multidisciplinary team of medical and nonmedical practitioners and volunteers, to modify homes for persons with disabilities. The programme recruited participants with physical disabilities and assessed their functioning difficulties. Participants’ homes were modified to address identified functioning difficulties. Local setting The project was implemented in four provinces in collaboration with staff from 27 district hospitals located in north-eastern Thailand. Relevant changes After the home modifications, all 43 recruited participants reported reduced difficulties in all areas, except for participants with severe degrees of difficulties, such as those reporting being unable to walk and unable to get up from the floor. The participants’ quality of life had also improved. The average EQ-5D-5L score, measuring quality of life, increased by 0.203 – from 0.346 at baseline to 0.549 after the modifications. Lessons learnt Home modifications in low-resourced settings are technically and financially feasible and can lead to reducing functioning difficulties and improving the quality of life of persons with disabilities. Implementation requires government subsidies to finance home modifications and the availability of technical guidelines and training on home modifications for implementing agents. PMID:28250515

Addendum to the Corrective Action Decision Document/Closure Report for Corrective Action Unit 406: Area 3 Building 03-74 & Building 03-58 Underground Discharge Points and Corrective Action Unit 429: Area 3 Building 03-55 & Area 9 Building 09-52 Underground Discharge Points, Tonopah Test Range, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the March 2000, Corrective Action Decision Document / Closure Report for Corrective Action Unit 406: Area 3 Building 03-74 & 03-58 Underground Discharge Points and Corrective Action Unit 429: Area 3 Building 03-55 & Area 9 Building 09-52 Underground Discharge Points (TTR) as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. Themore » approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 03-51-001-0355 – Photo Shop UDP, Drains in CAU 429. It should be noted that there are no changes to CAU 406. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Ink jet printing of silver metallization for photovoltaics

NASA Technical Reports Server (NTRS)

Vest, R. W.

1985-01-01

Progress was made in the continuing development of the ink jet printing system for thick film circuits. The unit being used is a prototype ink jet printer. One of the first tasks completed was the complete documentation of this ink jet printing system as it existed. It was determined that this was an essential step in deciding what modifications were needed to the system and how these modifications would be implemented. Design modification studies were started for electronic, mechanical, and programming aspects of the ystem. The areas needeing improvement were discussed and applicable changes decided upon. Some improvments were completed. Although the general areas needing improving were identified and some changes decided upon, the exact details of how other changes can be implemented are yet been decided.

Spray drift reduction evaluations of spray nozzles using a standardized testing protocol

USDA-ARS?s Scientific Manuscript database

The development and testing of drift reduction technologies has come to the forefront of application research in the past few years in the United States. Drift reduction technologies (DRTs) can be spray nozzles, sprayer modifications, spray delivery assistance, spray property modifiers (adjuvants),...

Thio-amide functionalized polymers via polymerization or post-polymerization modification

NASA Astrophysics Data System (ADS)

Ozcam, Ali; Henke, Adam; Stibingerova, Iva; Srogl, Jiri; Genzer, Jan

2011-03-01

Decreasing supplies of fresh water and increasing population necessitates development of advanced water cleaning technologies, which would facilitate the removal of water pollutants. Amongst the worst of such contaminants are heavy metals and cyanides, infamous for their high toxicity. To assist the water purification processes, we aim to synthesize functionalized macromolecules that would contribute in the decontamination processes by scavenging detrimental chemicals. Epitomizing this role thio-amide unit features remarkable chemical flexibility that facilitates reversible catch-release of the ions, where the behavior controlled by subtle red-ox changes in the environment. Chemical tunability of the thio-amide moiety enables synthesis of thio-amide based monomers and post-polymerization modification agents. Two distinct synthetic pathways, polymerization and post-polymerization modification, have been exploited, leading to functional thioamide-based macromolecules: thioamide-monomers were copolymerized with N-isopropylacrylamide and post-polymerization modifications of poly(dimethylaminoethyl methacrylate) and poly(propargyl methacrylate) were accomplished via quarternization and ``click'' reactions, respectively.

Crystal Growth Furnace System Configuration and Planned Experiments on the Second United States Microgravity Laboratory Mission

NASA Technical Reports Server (NTRS)

Srinivas, R.; Hambright, G.; Ainsworth, M.; Fiske, M.; Schaefer, D.

1995-01-01

The Crystal Growth Furnace (CGF) is currently undergoing modifications and refurbishment and is currently undergoing modifications and refurbishment and is manifested to refly on the Second United States Microgravity Laboratory (USML-2) mission scheduled for launch in September 1995. The CGF was developed for the National Aeronautics and Space Administration (NASA) under the Microgravity Science and Applications Division (MSAD) programs at NASA Headquarters. The refurbishment and reflight program is being managed by the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. Funding and program support for the CGF project is provided to MSFC by the office of Life and Microgravity Sciences and Applications at NASA Headquarters. This paper presents an overview of the CGF system configuration for the USML-2 mission, and provides a brief description of the planned on-orbit experiment operation.

Description of a dual fail operational redundant strapdown inertial measurement unit for integrated avionics systems research

NASA Technical Reports Server (NTRS)

Bryant, W. H.; Morrell, F. R.

1981-01-01

An experimental redundant strapdown inertial measurement unit (RSDIMU) is developed as a link to satisfy safety and reliability considerations in the integrated avionics concept. The unit includes four two degree-of-freedom tuned rotor gyros, and four accelerometers in a skewed and separable semioctahedral array. These sensors are coupled to four microprocessors which compensate sensor errors. These microprocessors are interfaced with two flight computers which process failure detection, isolation, redundancy management, and general flight control/navigation algorithms. Since the RSDIMU is a developmental unit, it is imperative that the flight computers provide special visibility and facility in algorithm modification.

15 CFR 908.5 - Interim reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.5 Interim reports. (a) Any person engaged in a weather modification project or activity in the United States on January 1 in any year shall submit to the... actual modification activities took place; (2) Number of days on which weather modification activities...

76 FR 61555 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... pieces unit welded, instead of 4 pieces unit with 3 welds (old design) as pictured in Appendix 1 of this... pre-modification 02447. Blue and Green. A300 airplanes post-modification 02447 Blue. A300-600 airplanes Blue. A310 airplanes Green. Table 2--Applicable Service Information Airbus Mandatory Service...

Including Students with Visual Impairments: Softball

ERIC Educational Resources Information Center

Brian, Ali; Haegele, Justin A.

2014-01-01

Research has shown that while students with visual impairments are likely to be included in general physical education programs, they may not be as active as their typically developing peers. This article provides ideas for equipment modifications and game-like progressions for one popular physical education unit, softball. The purpose of these…

78 FR 1759 - Notice of Approval of Clean Air Act Outer Continental Shelf Minor Source/Title V Minor Permit...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... Outer Continental Shelf Minor Source/Title V Minor Permit Modification Issued to Shell Offshore, Inc. for the Kulluk Conical Drilling Unit AGENCY: United States Environmental Protection Agency (EPA... decision granting Shell Offshore Inc.'s (``Shell'') request for minor modifications of Clean Air Act Outer...

75 FR 20774 - Modification of Jet Routes J-37 and J-55; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-21

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-0003; Airspace Docket No. 09-ANE-104] Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies Jet...

75 FR 77919 - Carolina Power & Light Company Shearon Harris Nuclear Power Plant, Unit 1; Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-14

... involves important physical modifications to the HNP, Unit 1 security system. There are several issues... in which some important security modifications are planned. A direct outside access route to the... implementation deadline, the licensee currently maintains a security system acceptable to the NRC and that will...

77 FR 5733 - Proposed Modification of Area Navigation (RNAV) Route Q-62; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Docket No. FAA-2011-1407; Airspace Docket No. 11-AGL-25 RIN 2120-AA66 Proposed Modification of Area Navigation (RNAV) Route Q-62; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

Change management methodologies trained for automotive infotainment projects

NASA Astrophysics Data System (ADS)

Prostean, G.; Volker, S.; Hutanu, A.

2017-01-01

An Automotive Electronic Control Units (ECU) development project embedded within a car Environment is constantly under attack of a continuous flow of modifications of specifications throughout the life cycle. Root causes for those modifications are for instance simply software or hardware implementation errors or requirement changes to satisfy the forthcoming demands of the market to ensure the later commercial success. It is unavoidable that from the very beginning until the end of the project “requirement changes” will “expose” the agreed objectives defined by contract specifications, which are product features, budget, schedule and quality. The key discussions will focus upon an automotive radio-navigation (infotainment) unit, which challenges aftermarket devises such as smart phones. This competition stresses especially current used automotive development processes, which are fit into a 4 Year car development (introduction) cycle against a one-year update cycle of a smart phone. The research will focus the investigation of possible impacts of changes during all phases of the project: the Concept-Validation, Development and Debugging-Phase. Building a thorough understanding of prospective threats is of paramount importance in order to establish the adequate project management process to handle requirement changes. Personal automotive development experiences and Literature review of change- and configuration management software development methodologies led the authors to new conceptual models, which integrates into the structure of traditional development models used in automotive projects, more concretely of radio-navigation projects.

Lighting design in the neonatal intensive care unit: practical applications of scientific principles.

PubMed

White, Robert D

2004-06-01

Meeting the varied lighting needs of infants, caregivers, and families has become more complex as our understanding of visual development and perception and the effect of light on circadian rhythms advances. Optimal lighting strategies are discussed for new unit construction, as well as modifications to consider for existing units. In either case, the key concept is that lighting should be provided for the individual needs of each person, rather than the full-room lighting schemes previously used. Ideas gleaned from nonhospital settings, re-introduction of natural light into the neonatal intensive care unit, and new devices such as light-emitting diodes will dramatically change the lighting and visual environment of future neonatal intensive care units.

On Precipitation Modification by Major Urban Areas: A New Perspective from TRMM

NASA Technical Reports Server (NTRS)

Pierce, Harold; Shepherd, J. Marshall; Starr, David OC. (Technical Monitor)

2001-01-01

By year 2025, 80% of the world's population will live in cities, according to a 1999 United Nation's report. As cities continue to grow, urban sprawl creates unique challenges related to land use planning, transportation, agriculture, housing, pollution, and development. Urban expansion also has measurable impact on environmental process.

Ecosystem classification, Chapter 2

Treesearch

M.J. Robin-Abbott; L.H. Pardo

2011-01-01

The ecosystem classification in this report is based on the ecoregions developed through the Commission for Environmental Cooperation (CEC) for North America (CEC 1997). Only ecosystems that occur in the United States are included. CEC ecoregions are described, with slight modifications, below (CEC 1997) and shown in Figures 2.1 and 2.2. We chose this ecosystem...

TiO2 induced structural modifications in Cs containing borosilicate glasses: Raman and infrared studies

NASA Astrophysics Data System (ADS)

Pandey, M.; Banerjee, D.; Sudarsan, V.; Kshirsagar, R. J.

2018-04-01

Effect of TiO2 addition in Cs containing Sodium-borosilicate glasses is studied using Raman and infrared spectroscopic techniques. As revealed from infrared and Raman studies, TiO2 does not form segregated phase, but instead enters into the borosilicate network. It is further observed that TiO2 addition results in modifications of the borate and silicate structural units by transforming into tetraborates and metasilicate structural units. These structural modifications are responsible for Cs immobilization, leach rate and chemical durability of these glasses.

75 FR 5704 - Proposed Modification of Jet Routes J-37 and J-55; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-0003; Airspace Docket No. 09-ANE-104] RIN 2120-AA66 Proposed Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

Identifying Corridors among Large Protected Areas in the United States

PubMed Central

Belote, R. Travis; Dietz, Matthew S.; McRae, Brad H.; Theobald, David M.; McClure, Meredith L.; Irwin, G. Hugh; McKinley, Peter S.; Gage, Josh A.; Aplet, Gregory H.

2016-01-01

Conservation scientists emphasize the importance of maintaining a connected network of protected areas to prevent ecosystems and populations from becoming isolated, reduce the risk of extinction, and ultimately sustain biodiversity. Keeping protected areas connected in a network is increasingly recognized as a conservation priority in the current era of rapid climate change. Models that identify suitable linkages between core areas have been used to prioritize potentially important corridors for maintaining functional connectivity. Here, we identify the most “natural” (i.e., least human-modified) corridors between large protected areas in the contiguous Unites States. We aggregated results from multiple connectivity models to develop a composite map of corridors reflecting agreement of models run under different assumptions about how human modification of land may influence connectivity. To identify which land units are most important for sustaining structural connectivity, we used the composite map of corridors to evaluate connectivity priorities in two ways: (1) among land units outside of our pool of large core protected areas and (2) among units administratively protected as Inventoried Roadless (IRAs) or Wilderness Study Areas (WSAs). Corridor values varied substantially among classes of “unprotected” non-core land units, and land units of high connectivity value and priority represent diverse ownerships and existing levels of protections. We provide a ranking of IRAs and WSAs that should be prioritized for additional protection to maintain minimal human modification. Our results provide a coarse-scale assessment of connectivity priorities for maintaining a connected network of protected areas. PMID:27104683

Identifying Corridors among Large Protected Areas in the United States.

PubMed

Belote, R Travis; Dietz, Matthew S; McRae, Brad H; Theobald, David M; McClure, Meredith L; Irwin, G Hugh; McKinley, Peter S; Gage, Josh A; Aplet, Gregory H

2016-01-01

Conservation scientists emphasize the importance of maintaining a connected network of protected areas to prevent ecosystems and populations from becoming isolated, reduce the risk of extinction, and ultimately sustain biodiversity. Keeping protected areas connected in a network is increasingly recognized as a conservation priority in the current era of rapid climate change. Models that identify suitable linkages between core areas have been used to prioritize potentially important corridors for maintaining functional connectivity. Here, we identify the most "natural" (i.e., least human-modified) corridors between large protected areas in the contiguous Unites States. We aggregated results from multiple connectivity models to develop a composite map of corridors reflecting agreement of models run under different assumptions about how human modification of land may influence connectivity. To identify which land units are most important for sustaining structural connectivity, we used the composite map of corridors to evaluate connectivity priorities in two ways: (1) among land units outside of our pool of large core protected areas and (2) among units administratively protected as Inventoried Roadless (IRAs) or Wilderness Study Areas (WSAs). Corridor values varied substantially among classes of "unprotected" non-core land units, and land units of high connectivity value and priority represent diverse ownerships and existing levels of protections. We provide a ranking of IRAs and WSAs that should be prioritized for additional protection to maintain minimal human modification. Our results provide a coarse-scale assessment of connectivity priorities for maintaining a connected network of protected areas.

78 FR 45565 - Notice of Lodging of Proposed Modification to Settlement Agreement Under the Clean Water Act

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... DEPARTMENT OF JUSTICE Notice of Lodging of Proposed Modification to Settlement Agreement Under the Clean Water Act On July 23, 2013, the Department of Justice lodged a proposed Third Modification to the Settlement Agreement and Final Order (``Third Modification'') in United States and State of California ex rel. California Regional Water Quality...

76 FR 79140 - Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

...-0654; Airspace Docket No. 11-AWP-8] RIN 2120-AA66 Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... omnidirectional range (VOR) Federal airways V-135 and V-137 by extending the airways to the Mexicali, Mexico VOR...

A New Sand-Culture Apparatus for Tree Nutrition Research

Treesearch

B. G. Blackmon; N. E. Linnartz

1970-01-01

Research in tree nutrition often necessitates the use of rather large-scale installations of sand-culture equipment. The apparatus described below was developed during the course of experiments at Louisiana State University and provided daily irrigation to 102 culture units of loblolly pine (Pinus taeda L.) for a period of 10 months. This apparatus is a modification of...

Taper models for commercial tree species in the northeastern United States

Treesearch

James A. Westfall; Charles T. Scott

2010-01-01

A new taper model was developed based on the switching taper model of Valentine and Gregoire; the most substantial changes were reformulation to incorporate estimated join points and modification of a switching function. Random-effects parameters were included that account for within-tree correlations and allow for customized calibration to each individual tree. The...

New GIS approaches to wild land mapping in Europe

Treesearch

Steffen Fritz; Steve Carver; Linda See

2000-01-01

This paper outlines modifications and new approaches to wild land mapping developed specifically for the United Kingdom and European areas. In particular, national level reconnaissance and local level mapping of wild land in the UK and Scotland are presented. A national level study for the UK is undertaken, and a local study focuses on the Cairngorm Mountains in...

Oak Seedlings: Quality Improved Available Now Genetically Improved Available Soon

Treesearch

S.E. Schlarbaum; Paul P. Kormanik; T. Tibbs; L.R. Barber

1997-01-01

Technology for obtaining natural oak regeneration on low quality upland sites, e.g. site indices of 60-65 or less, was developed in the Central Statesregion and has been successfully applied throughout the eastern United States (Sanderand Graney 1993, Clark 1993, Sander 1972). Modification of this technology for use on high quality mesic sites, productive coves and...

15 CFR 908.4 - Initial report.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.4 Initial report. (a) Any person intending to engage in any weather modification project or activity in the United States shall provide a report of his... operator for the project or activity; (2) The following dates for weather modification activities: (i) The...

Land-atmosphere interactions over the continental United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, Xubin

This paper briefly discusses four suggested modifications for land surface modeling in climate models. The impact of the modifications on climate simulations is analyzed with the Biosphere-Atmosphere Transfer Scheme (BATS) land surface model. It is found that the modifications can improve BATS simulations. In particular, the sensitivity of BATS to the prescribed value of physical root fraction which cannot be observed from satellite remote sensing or field experiments is improved. These modifications significantly reduce the excessive summer land surface temperature over the continental United States simulated by the National Center for Atmospheric Research Community Climate Model (CCM2) coupled with BATS.more » A land-atmosphere interaction mechanism involving energy and water cycles is proposed to explain the results. 9 refs., 1 fig.« less

Lipoprotein Profile Modifications during Gestation: A Current Approach to Cardiovascular risk surrogate markers and Maternal-fetal Unit Complications.

PubMed

Santos, Ana Paula Caires Dos; Couto, Ricardo David

2018-05-16

Several changes occur in lipid metabolism during gestation due to hormonal and metabolic changes, which are essential to satisfy the nutritional demands of the maternal-fetal unit development. The gestation shows two distinct periods that begin with fat accumulation, mainly in maternal adipose tissue, and the late phase, characterized by accelerated catabolism, with the increase of fatty acids in the circulation that causes hyperlipidemia, especially the one characterized as hypertriglyceridemia. Maternal hyperlipidemia may be associated with the development of maternal-fetal complications (preterm birth, preeclampsia, vascular complications) and the development of long-term cardiovascular disease. The cardiovascular risk may not only be related to lipoproteins cholesterol content, but also to the number and functionality of circulating lipoprotein particles. This review reports the major changes that occur in lipoprotein metabolism during pregnancy and that are associated with the development of dyslipidemias, lipoprotein atherogenic phenotype, and maternal-fetal unit complications. Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil.

Embedding technology into inter-professional best practices in home safety evaluation.

PubMed

Burns, Suzanne Perea; Pickens, Noralyn Davel

2017-08-01

To explore inter-professional home evaluators' perspectives and needs for building useful and acceptable decision-support tools for the field of home modifications. Twenty semi-structured interviews were conducted with a range of home modification professionals from different regions of the United States. The interview transcripts were analyzed with a qualitative, descriptive, perspective approach. Technology supports current best practice and has potential to inform decision making through features that could enhance home evaluation processes, quality, efficiency and inter-professional communication. Technological advances with app design have created numerous opportunities for the field of home modifications. Integrating technology and inter-professional best practices will improve home safety evaluation and intervention development to meet client-centred and societal needs. Implications for rehabilitation Understanding home evaluators technology needs for home safety evaluations contributes to the development of app-based assessments. Integrating inter-professional perspectives of best practice and technological needs in an app for home assessments improves processes. Novice and expert home evaluators would benefit from decision support systems embedded in app-based assessments. Adoption of app-based assessment would improve efficiency while remaining client-centred.

Modification of a pollen trap design to capture airborne conidia of Entomophaga maimaiga and detection of conidia by quantitative PCR

Treesearch

Tonya D. Bittner; Ann E. Hajek; Andrew M. Liebhold; Harold Thistle; Dan Cullen

2017-01-01

The goal of this study was to develop effective and practical field sampling methods for quantification of aerial deposition of airborne conidia of Entomophaga maimaiga over space and time. This important fungal pathogen is a major cause of larval death in invasive gypsy moth (Lymantria dispar) populations in the United States...

15 CFR 908.2 - Persons subject to reporting.

Code of Federal Regulations, 2013 CFR

2013-01-01

...-ORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.2 Persons subject to reporting. Any person engaged or intending to engage in any weather modification activity in the United States...

15 CFR 908.2 - Persons subject to reporting.

Code of Federal Regulations, 2014 CFR

2014-01-01

...-ORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.2 Persons subject to reporting. Any person engaged or intending to engage in any weather modification activity in the United States...

15 CFR 908.2 - Persons subject to reporting.

Code of Federal Regulations, 2012 CFR

2012-01-01

...- ORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.2 Persons subject to reporting. Any person engaged or intending to engage in any weather modification activity in the United States...

15 CFR 908.2 - Persons subject to reporting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... RECORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.2 Persons subject to reporting. Any person engaged or intending to engage in any weather modification activity in the United States...

75 FR 7627 - Notice of Lodging of Material Modification to Consent Decree under the Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... proposed First Material Modification to Consent Decree (``First Decree Modification'') in United States, et al. v. Bunge North America, Inc., et al., Civil Action No. 2:06-cv-02209- MPM-DGB (C.D. Ill.) was... owned and operated by Bunge North America, Inc. and several affiliated entities (collectively referred...

Superfund explanation of significant difference for the record of decision (EPA region 2): Love Canal, Niagara Falls, NY, September 5, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The United States Environmental Protection Agency (EPA) and the New York State Department of Environmental Conservation (NYSDEC) announce this Explanation of Significant Differences (ESD) to explain modifications to the selected remedy for the final destruction and disposal of Love Canal dioxin-contaminated sewer and creek sediments. These modifications are embodied in proposed changes to a partial consent decree between the United States and the State of New York and the Occidental Chemical Corporation (OCC) in the United States District Court for the Western District of New York.

KSC-03pd0262

NASA Image and Video Library

2003-02-04

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians install thermal protection system tiles on Space Shuttle Discovery. Discovery is undergoing its Orbiter Major Modification Period, a regularly scheduled structural inspection and modification downtime, which began in September 2002. .

Addendum to the Closure Report for Corrective Action Unit 335: Area 6 Injection Well and Drain Pit Nevada Test Site, Nevada, Revison 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the June 2003, Closure Report for Corrective Action Unit 335: Area 6 Injection Well and Drain Pit as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consistsmore » of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 06-20-02, 20-inch Cased Hole • CAS 06-23-03, Drain Pit These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Addendum to the Closure Report for Corrective Action Unit 356: Mud Pits and Disposal Sites Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the November 2002, Closure Report for Corrective Action Unit 356: Mud Pits and Disposal Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: •more » This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 03-04-01, Area 3 Change House Septic System • CAS 03-09-04, Mud Pit These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Addendum to the Closure Report for Corrective Action Unit 398: Area 25 Spill Sites, Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the April 2003, Closure Report for Corrective Action Unit 398: Area 25 Spill Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • Thismore » cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 25-25-17, Subsurface Hydraulic Oil Spill. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Addendum to the Closure Report for Corrective Action Unit 214: Bunkers and Storage Areas Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the September 2006, Closure Report for Corrective Action Unit 214: Bunkers and Storage Areas as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • Thismore » cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 25-23-01, Contaminated Materials • CAS 25-23-19, Radioactive Material Storage These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Addendum to the Closure Report for Corrective Action Unit 342: Area 23 Mercury Fire Training Pit Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the April 2000, Closure Report for Corrective Action Unit 342: Area 23 Mercury Fire Training Pit as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of:more » • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 23-56-01, Former Mercury Fire Training Pit. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Addendum to the Closure Report for Corrective Action Unit 322: Areas 1 & 3 Release Sites and Injection Wells Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the June 2006, Closure Report for Corrective Action Unit 322: Areas 1 & 3 Release Sites and Injection Wells as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, thismore » addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 01-25-01, AST Release • CAS 03-25-03, Mud Plant AST Diesel Release These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

40 CFR 63.1281 - Control equipment requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... dehydration unit baseline operations (as defined in § 63.1271). Records of glycol dehydration unit baseline... the Administrator's satisfaction, the conditions for which glycol dehydration unit baseline operations... emission reduction of 95.0 percent for the glycol dehydration unit process vent. Only modifications in...

40 CFR 63.1281 - Control equipment requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... dehydration unit baseline operations (as defined in § 63.1271). Records of glycol dehydration unit baseline... the Administrator's satisfaction, the conditions for which glycol dehydration unit baseline operations... emission reduction of 95.0 percent for the glycol dehydration unit process vent. Only modifications in...

Trophic interaction modifications: an empirical and theoretical framework.

PubMed

Terry, J Christopher D; Morris, Rebecca J; Bonsall, Michael B

2017-10-01

Consumer-resource interactions are often influenced by other species in the community. At present these 'trophic interaction modifications' are rarely included in ecological models despite demonstrations that they can drive system dynamics. Here, we advocate and extend an approach that has the potential to unite and represent this key group of non-trophic interactions by emphasising the change to trophic interactions induced by modifying species. We highlight the opportunities this approach brings in comparison to frameworks that coerce trophic interaction modifications into pairwise relationships. To establish common frames of reference and explore the value of the approach, we set out a range of metrics for the 'strength' of an interaction modification which incorporate increasing levels of contextual information about the system. Through demonstrations in three-species model systems, we establish that these metrics capture complimentary aspects of interaction modifications. We show how the approach can be used in a range of empirical contexts; we identify as specific gaps in current understanding experiments with multiple levels of modifier species and the distributions of modifications in networks. The trophic interaction modification approach we propose can motivate and unite empirical and theoretical studies of system dynamics, providing a route to confront ecological complexity. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

Nesting pair density and abundance of ferruginous hawks (Buteo regalis) and golden eagles (Aquila chrysaetos) from aerial surveys in Wyoming

Treesearch

Lucretia E. Olson; Robert J. Oakleaf; John R. Squires; Zachary P. Wallace; Patricia L. Kennedy

2015-01-01

Raptors that inhabit sagebrush steppe and grassland ecosystems in the western United States may be threatened by continued loss and modification of their habitat due to energy development, conversion to agriculture, and human encroachment. Actions to protect these species are hampered by a lack of reliable data on such basic information as population size and...

Sustaining a "culture of silence" in the neonatal intensive care unit during nonemergency situations: a grounded theory on ensuring adherence to behavioral modification to reduce noise levels.

PubMed

Swathi, S; Ramesh, A; Nagapoornima, M; Fernandes, Lavina M; Jisina, C; Rao, P N Suman; Swarnarekha, A

2014-01-01

The aim of this study was to generate a substantive theory explaining how the staff in a resource-limited neonatal intensive care unit (NICU) of a developing nation manage to ensure adherence to behavioral modification components of a noise reduction protocol (NsRP) during nonemergency situations. The study was conducted after implementation of an NsRP in a level III NICU of south India. The normal routine of the NICU is highly dynamic because of various categories of staff conducting clinical rounds followed by care-giving activities. This is unpredictably interspersed with very noisy emergency management of neonates who suddenly fall sick. In-depth interviews were conducted with 36 staff members of the NICU (20 staff nurses, six nursing aides, and 10 physicians). Group discussions were conducted with 20 staff nurses and six nursing aides. Data analysis was done in line with the reformulated grounded theory approach, which was based on inductive examination of textual information. The results of the analysis showed that the main concern was to ensure adherence to behavioral modification components of the NsRP. This was addressed by using strategies to "sustain a culture of silence in NICU during nonemergency situations" (core category). The main strategies employed were building awareness momentum, causing awareness percolation, developing a sense of ownership, expansion of caring practices, evolution of adherence, and displaying performance indicators. The "culture of silence" reconditions the existing staff and conditions new staff members joining the NICU. During emergency situations, a "noisy culture" prevailed because of pragmatic neglect of behavioral modification when life support overrode all other concerns. In addition to this, the process of operant conditioning should be formally conducted once every 18 months. The results of this study may be adapted to create similar strategies and establish context specific NsRPs in NICUs with resource constraints.

77 FR 57010 - Modification of Area Navigation (RNAV) Route Q-62; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-17

...; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY... proposed rulemaking to modify RNAV route Q-62 in Northeast United States by extending it further west (77...

Research pressure instrumentation for NASA Space Shuttle main engine, modification no. 5

NASA Technical Reports Server (NTRS)

Anderson, P. J.; Nussbaum, P.; Gustafson, G.

1984-01-01

The purpose of Modification No. 5 of this contract is to expand the scope of work (Task C) of this research study effort to develop pressure instrumentation for the SSME. The objective of this contract (Task C) is to direct Honeywell's Solid State Electronics Division's (SSED) extensive experience and expertise in solid state sensor technology to develop prototype pressure transducers which are targeted to meet the SSME performance design goals and to fabricate, test and deliver a total of 10 prototype units. SSED's basic approach is to effectively utilize the many advantages of silicon piezoresistive strain sensing technology to achieve the objectives of advanced state-of-the-art pressure sensors in terms of reliability, accuracy and ease of manufacture. More specifically, integration of multiple functions on a single chip is the key attribute of this technology which will be exploited during this research study.

Lunar module voice recorder

NASA Technical Reports Server (NTRS)

1974-01-01

A feasibility unit suitable for use as a voice recorder on the space shuttle was developed. A modification, development, and test program is described. A LM-DSEA recorder was modified to achieve the following goals: (1) redesign case to allow in-flight cartridge change; (2) time code change from LM code to IRIG-B 100 pps code; (3) delete cold plate requirements (also requires deletion of long-term thermal vacuum operation at 0.00001 MMHg); (4) implement track sequence reset during cartridge change; (5) reduce record time per cartridge because of unavailability of LM thin-base tape; and (6) add an internal Vox key circuit to turn on/off transport and electronics with voice data input signal. The recorder was tested at both the LM and shuttle vibration levels. The modified recorder achieved the same level of flutter during vibration as the DSEA recorder prior to modification. Several improvements were made over the specification requirements. The high manufacturing cost is discussed.

Patterned Colloidal Photonic Crystals.

PubMed

Hou, Jue; Li, Mingzhu; Song, Yanlin

2018-03-01

Colloidal photonic crystals (PCs) have been well developed because they are easy to prepare, cost-effective, and versatile with regards to modification and functionalization. Patterned colloidal PCs contribute a novel approach to constructing high-performance PC devices with unique structures and specific functions. In this review, an overview of the strategies for fabricating patterned colloidal PCs, including patterned substrate-induced assembly, inkjet printing, and selective immobilization and modification, is presented. The advantages of patterned PC devices are also discussed in detail, for example, improved detection sensitivity and response speed of the sensors, control over the flow direction and wicking rate of microfluidic channels, recognition of cross-reactive molecules through an array-patterned microchip, fabrication of display devices with tunable patterns, well-arranged RGB units, and wide viewing-angles, and the ability to construct anti-counterfeiting devices with different security strategies. Finally, the perspective of future developments and challenges is presented. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Suggestions for Modifications in the Teaching of General Chemistry to Accommodate Learning Disabled Students: Alternative Techniques for Teaching General Chemistry to Learning Disabled Students in the University.

ERIC Educational Resources Information Center

Habib, H. S.

A professor involved with the HELDS project (Higher Education for Learning Disabled Students) describes modifications in a general chemistry course. A syllabus lists program objectives for eight text chapters, evaluation components, and course rules. Two units are described in detail, with information presented on modifications made for LD…

Addendum to the Closure Report for Corrective Action Unit 427: Area 3 Septic Waste Systems 2, 6, Tonopah Test Range, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the April 1999, Closure Report for Corrective Action Unit 427: Area 3 Septic Waste Systems 2, 6, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modificationmore » document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 03-05-002-SW02, Septic Waste System • CAS 03-05-002-SW06, Septic Waste System These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Addendum to the Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 454: Historical Undrground Storage Tank Release Sites, Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the April 1998, Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 454: Historical Underground Storage Tank Release Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modificationmore » document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 12-25-09, Spill 960722-02 (from UST 12-B-3). This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Addendum to the Corrective Action Decision Document/Closure Report for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the August 2001, Corrective Action Decision Document / Closure Report for Corrective Action Unit 321: Area 22 Weather Station Fuel Storage as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modificationmore » document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 22-99-05, Fuel Storage Area. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Addendum to the Closure Report for Corrective Action Unit 423: Area 3 Building 03-60 Underground Discharge Point, Tonopah Test Range, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the July 1999, Closure Report for Corrective Action Unit 423: Area 3 Building 0360 Underground Discharge Point, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modificationmore » document, this addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the UR for CAS 03-02-002-0308, Underground Discharge Point. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove the UR because contamination is not present at the site above the risk-based FALs. Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Continued urbanization of the United States is causing the deterioration of the central city; costly suburban developments; and increases in congestion, pollution, crime, violence and alienation

NASA Technical Reports Server (NTRS)

1975-01-01

It is shown that urban sprawl and the abuses of technological industries result in substantial environmental and economic costs at the expense of center city locations and populations. Socioeconomic deterioration and modification of the biosphere triggers climatic and environmental changes leading to ecosystem damage and destruction, health consequences and international conflict.

Near hybrid passenger vehicle development program, phase 1. Appendices C and D, Volume 2

NASA Technical Reports Server (NTRS)

1979-01-01

Results of tradeoff studies are presented in summary form. Various aspects of the overall vehicle design discussed include selection of the base vehicle, the battery pack configuration, structural modifications, occupant protection, vehicle dynamics, and aerodynamics. The drivetrain design and integration, power conditioning unit, battery subsystem, control system, environmental system are described. Specifications, weight breakdown, and energy consumption measures, and advanced technology components are included.

Modifications to the NRAD Reactor, 1977 to present

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weeks, A.A.; Pruett, D.P.; Heidel, C.C.

1986-01-01

Argonne National Laboratory-West, operated by the University of Chicago, is located near Idaho Falls, ID, on the Idaho National Engineering laboratory Site. ANL-West performs work in support of the Liquid Metal Fast Breeder Reactor Program (LMFBR) sponsored by the United States Department of Energy. The NRAD reactor is located at the Argonne Site within the Hot Fuel Examination Facility/North, a large hot cell facility where both non-destructive and destructive examinations are performed on highly irradiated reactor fuels and materials in support of the LMFBR program. The NRAD facility utilizes a 250-kW TRIGA reactor and is completely dedicated to neutron radiographymore » and the development of radiography techniques. Criticality was first achieved at the NRAD reactor in October of 1977. Since that time, a number of modifications have been implemented to improve operational efficiency and radiography production. This paper describes the modifications and changes that significantly improved operational efficiency and reliability of the reactor and the essential auxiliary reactor systems.« less

Fractal-Inspired Subwavelength Geometric Inclusions for Improvement of High-Frequency Electromagnetic Devices

NASA Astrophysics Data System (ADS)

Smith, Kathryn Leigh

This dissertation presents research results demonstrating the efficacy of fractal-inspired subwavelength geometric inclusions for improvement of high-frequency electromagnetic devices. It begins with a review of the open literature in the area of fractal applications in antennas and metamaterials. This is followed by a detailed discussion of three high-frequency electromagnetic devices that demonstrate performance improvement through incorporation of subwavelength geometric design elements. The first of these devices is a spherical spiral metamaterial unit cell that was developed as a three-dimensional fractal expansion of the traditional split ring resonator, and is shown to be capable of producing broadband negative permeability, negative permittivity, or both, depending solely on the orientation of the unit cells with respect to the incident electric field. The second device is a ringed rectangular patch antenna that has four resonant frequencies. All four of these operative frequencies are shown to produce similar radiation patterns, which also closely match the pattern of a traditional patch antenna. Several minor geometric modifications of the basic shape of the device are also presented, and are shown to enable modification of the number of resonances, as well as tuning of frequencies of resonance. The third and final topic is a modified horn antenna that incorporates a spiral metamaterial as a phase-shifting device in order to achieve circularly polarized radiation. The handedness of the radiated wave is shown to be tunable through simple reorientation of the loading unit cells. In each of these cases, electrically-small geometric modification of existing device geometries is shown to greatly affect performance, either by increasing bandwidth, by inducing multiband behavior, or by enabling exotic radiation characteristics.

15 CFR 908.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.1 Definitions. As used in this part, terms shall... contractor of the Federal government. (c) Weather modification activity. Any activity performed with the... territory or insular possession of the United States. (e) Persons whose activities relate to weather...

15 CFR 908.1 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.1 Definitions. As used in this part, terms shall... contractor of the Federal government. (c) Weather modification activity. Any activity performed with the... territory or insular possession of the United States. (e) Persons whose activities relate to weather...

15 CFR 908.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.1 Definitions. As used in this part, terms shall... contractor of the Federal government. (c) Weather modification activity. Any activity performed with the... territory or insular possession of the United States. (e) Persons whose activities relate to weather...

15 CFR 908.1 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.1 Definitions. As used in this part, terms shall... contractor of the Federal government. (c) Weather modification activity. Any activity performed with the... territory or insular possession of the United States. (e) Persons whose activities relate to weather...

15 CFR 908.1 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.1 Definitions. As used in this part, terms shall... contractor of the Federal government. (c) Weather modification activity. Any activity performed with the... territory or insular possession of the United States. (e) Persons whose activities relate to weather...

Solar stills for agricultural purposes

NASA Technical Reports Server (NTRS)

Selcuk, M. K.; Tran, V. V.

1975-01-01

Basic concepts of using desalinated water for agricultural purposes are outlined. A mathematical model describing heat and mass transfer in a system combining a solar still with a greenhouse, its solution, and test results of a small-scale unit built at the Middle East Technical University, Ankara, Turkey, are discussed. The unit was employed to demonstrate the technical feasibility of the system. Further development and modifications are necessary for larger-scale operations. The basis of an optimization study which is underway at the Brace Research Institute of McGill University in Montreal, Canada, aimed at finding the best combination of design and operation parameters is also presented.

Using ant-behavior-based simulation model AntWeb to improve website organization

NASA Astrophysics Data System (ADS)

Li, Weigang; Pinheiro Dib, Marcos V.; Teles, Wesley M.; Morais de Andrade, Vlaudemir; Alves de Melo, Alba C. M.; Cariolano, Judas T.

2002-03-01

Some web usage mining algorithms showed the potential application to find the difference among the organizations expected by visitors to the website. However, there are still no efficient method and criterion for a web administrator to measure the performance of the modification. In this paper, we developed an AntWeb, a model inspired by ants' behavior to simulate the sequence of visiting the website, in order to measure the efficient of the web structure. We implemented a web usage mining algorithm using backtrack to the intranet website of the Politec Informatic Ltd., Brazil. We defined throughput (the number of visitors to reach their target pages per time unit relates to the total number of visitors) as an index to measure the website's performance. We also used the link in a web page to represent the effect of visitors' pheromone trails. For every modification in the website organization, for example, putting a link from the expected location to the target object, the simulation reported the value of throughput as a quick answer about this modification. The experiment showed the stability of our simulation model, and a positive modification to the intranet website of the Politec.

Addendum to the Closure Report for Corrective Action Unit 358: Areas 18, 19, 20 Cellars/Mud Pits Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the January 2004, Closure Report for Corrective Action Unit 358: Areas 18, 19, 20 Cellars/Mud Pits as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of:more » • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 20-23-02, Postshot Cellar • CAS 20-23-03, Cellar • CAS 20-23-04, Postshot Cellar • CAS 20-23-05, Postshot Cellar • CAS 20-23-06, Cellar • CAS 20-37-01, Cellar & Mud Pit • CAS 20-37-05, Cellar These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Addendum to the Closure Report for Corrective Action Unit 394: Areas 12, 18, and 29 Spill/Release Sites Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the September 2003, Closure Report for Corrective Action Unit 394: Areas 12, 18, and 29 Spill/Release Sites as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consistsmore » of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 12-25-04, UST 12-16-2 Waste Oil Release • CAS 18-25-01, Oil Spills • CAS 18-25-02, Oil Spills • CAS 18-25-03, Oil Spill • CAS 29-44-01, Fuel Spill These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Hollow cathode heater development for the Space Station plasma contactor

NASA Technical Reports Server (NTRS)

Soulas, George C.

1993-01-01

A hollow cathode-based plasma contactor has been selected for use on the Space Station. During the operation of the plasma contactor, the hollow cathode heater will endure approximately 12000 thermal cycles. Since a hollow cathode heater failure would result in a plasma contactor failure, a hollow cathode heater development program was established to produce a reliable heater design. The development program includes the heater design, process documents for both heater fabrication and assembly, and heater testing. The heater design was a modification of a sheathed ion thruster cathode heater. Three heaters have been tested to date using direct current power supplies. Performance testing was conducted to determine input current and power requirements for achieving activation and ignition temperatures, single unit operational repeatability, and unit-to-unit operational repeatability. Comparisons of performance testing data at the ignition input current level for the three heaters show the unit-to-unit repeatability of input power and tube temperature near the cathode tip to be within 3.5 W and 44 degrees C, respectively. Cyclic testing was then conducted to evaluate reliability under thermal cycling. The first heater, although damaged during assembly, completed 5985 ignition cycles before failing. Two additional heaters were subsequently fabricated and have completed 3178 cycles to date in an on-going test.

Automated solar panel assembly line

NASA Technical Reports Server (NTRS)

Somberg, H.

1981-01-01

The initial stage of the automated solar panel assembly line program was devoted to concept development and proof of approach through simple experimental verification. In this phase, laboratory bench models were built to demonstrate and verify concepts. Following this phase was machine design and integration of the various machine elements. The third phase was machine assembly and debugging. In this phase, the various elements were operated as a unit and modifications were made as required. The final stage of development was the demonstration of the equipment in a pilot production operation.

Modifying Softball for Maximizing Learning Outcomes in Physical Education

ERIC Educational Resources Information Center

Brian, Ali; Ward, Phillip; Goodway, Jacqueline D.; Sutherland, Sue

2014-01-01

Softball is taught in many physical education programs throughout the United States. This article describes modifications that maximize learning outcomes and that address the National Standards and safety recommendations. The modifications focus on tasks and equipment, developmentally appropriate motor-skill acquisition, increasing number of…

19 CFR 210.74 - Modification of reporting requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Modification of reporting requirements. 210.74 Section 210.74 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Enforcement Procedures and Advisory Opinions § 210.74...

SRB Altitude Switch Assembly Wire Harness Failure

NASA Technical Reports Server (NTRS)

Blanche, Jim

2002-01-01

This paper presents an assessment of two wire harness failures that had occurred in Solid Rocket Booster Altitude Switch Assemblies S/N 200001 and S/N 20002. A list of modifications to EDU #4 and modification of qualification units 2000001 and 2000002 are also presented.

Divisions of geologic time-major chronostratigraphic and geochronologic units

USGS Publications Warehouse

,

2010-01-01

Effective communication in the geosciences requires consistent uses of stratigraphic nomenclature, especially divisions of geologic time. A geologic time scale is composed of standard stratigraphic divisions based on rock sequences and is calibrated in years. Over the years, the development of new dating methods and the refinement of previous methods have stimulated revisions to geologic time scales. Advances in stratigraphy and geochronology require that any time scale be periodically updated. Therefore, Divisions of Geologic Time, which shows the major chronostratigraphic (position) and geochronologic (time) units, is intended to be a dynamic resource that will be modified to include accepted changes of unit names and boundary age estimates. This fact sheet is a modification of USGS Fact Sheet 2007-3015 by the U.S. Geological Survey Geologic Names Committee.

40 CFR 49.153 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... this section). (C) Step 3. If any of the emissions units affected by your proposed modification result... not subject to this program. (2) Increase in an emissions unit's annual allowable emissions limit. If... emissions unit's allowable emissions of a regulated NSR pollutant above its existing annual allowable...

40 CFR 49.153 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... this section). (C) Step 3. If any of the emissions units affected by your proposed modification result... not subject to this program. (2) Increase in an emissions unit's annual allowable emissions limit. If... emissions unit's allowable emissions of a regulated NSR pollutant above its existing annual allowable...

40 CFR 49.153 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... this section). (C) Step 3. If any of the emissions units affected by your proposed modification result... not subject to this program. (2) Increase in an emissions unit's annual allowable emissions limit. If... emissions unit's allowable emissions of a regulated NSR pollutant above its existing annual allowable...

Surface Modification of Orthodontic Bracket Models via Ion Implantation: Effect on Coefficients of Friction

DTIC Science & Technology

1989-01-01

FEB 2 2 1990 Stephen Walter Andrews, D.M.D. The University of North Carolina at Chapel Hill Department of Orthodontics School of Dentistry 1989 Robert...PROJECT TASK WORK UNIT ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (Include Security Classification) (UNCLASSIFIED) SURFACE MODIFICATION OF ORTHODONTIC ...Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE AFIT/CI "OVERPRINT" SURFACE MODIFICATION OF ORTHODONTIC BRACKET MODELS VIA ION

19 CFR 210.74 - Modification of reporting requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Modification of reporting requirements. 210.74 Section 210.74 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR... assist the U.S. Customs Service in ascertaining that there has been compliance with an outstanding...

19 CFR 210.74 - Modification of reporting requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Modification of reporting requirements. 210.74 Section 210.74 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR... assist the U.S. Customs Service in ascertaining that there has been compliance with an outstanding...

19 CFR 210.74 - Modification of reporting requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Modification of reporting requirements. 210.74 Section 210.74 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR... assist the U.S. Customs Service in ascertaining that there has been compliance with an outstanding...

78 FR 48286 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... installed on both LH and RH sides (Airbus modification 153655 applied in production, or modified in-service... unit (LGCIU) interlink communication ARINC 429 (applied in production through Airbus Modification (mod... of MLG actuator Part Number (P/N) 114122014 through Airbus SB A320-32-1407 (Airbus production mod...

Optimising the Inflammatory Bowel Disease Unit to Improve Quality of Care: Expert Recommendations.

PubMed

Louis, Edouard; Dotan, Iris; Ghosh, Subrata; Mlynarsky, Liat; Reenaers, Catherine; Schreiber, Stefan

2015-08-01

The best care setting for patients with inflammatory bowel disease [IBD] may be in a dedicated unit. Whereas not all gastroenterology units have the same resources to develop dedicated IBD facilities and services, there are steps that can be taken by any unit to optimise patients' access to interdisciplinary expert care. A series of pragmatic recommendations relating to IBD unit optimisation have been developed through discussion among a large panel of international experts. Suggested recommendations were extracted through systematic search of published evidence and structured requests for expert opinion. Physicians [n = 238] identified as IBD specialists by publications or clinical focus on IBD were invited for discussion and recommendation modification [Barcelona, Spain; 2014]. Final recommendations were voted on by the group. Participants also completed an online survey to evaluate their own experience related to IBD units. A total of 60% of attendees completed the survey, with 15% self-classifying their centre as a dedicated IBD unit. Only half of respondents indicated that they had a defined IBD treatment algorithm in place. Key recommendations included the need to develop a multidisciplinary team covering specifically-defined specialist expertise in IBD, to instil processes that facilitate cross-functional communication and to invest in shared care models of IBD management. Optimising the setup of IBD units will require progressive leadership and willingness to challenge the status quo in order to provide better quality of care for our patients. IBD units are an important step towards harmonising care for IBD across Europe and for establishing standards for disease management programmes. © European Crohn’s and Colitis Organisation 2015.

Optimising the Inflammatory Bowel Disease Unit to Improve Quality of Care: Expert Recommendations

PubMed Central

Dotan, Iris; Ghosh, Subrata; Mlynarsky, Liat; Reenaers, Catherine; Schreiber, Stefan

2015-01-01

Introduction: The best care setting for patients with inflammatory bowel disease [IBD] may be in a dedicated unit. Whereas not all gastroenterology units have the same resources to develop dedicated IBD facilities and services, there are steps that can be taken by any unit to optimise patients’ access to interdisciplinary expert care. A series of pragmatic recommendations relating to IBD unit optimisation have been developed through discussion among a large panel of international experts. Methods: Suggested recommendations were extracted through systematic search of published evidence and structured requests for expert opinion. Physicians [n = 238] identified as IBD specialists by publications or clinical focus on IBD were invited for discussion and recommendation modification [Barcelona, Spain; 2014]. Final recommendations were voted on by the group. Participants also completed an online survey to evaluate their own experience related to IBD units. Results: A total of 60% of attendees completed the survey, with 15% self-classifying their centre as a dedicated IBD unit. Only half of respondents indicated that they had a defined IBD treatment algorithm in place. Key recommendations included the need to develop a multidisciplinary team covering specifically-defined specialist expertise in IBD, to instil processes that facilitate cross-functional communication and to invest in shared care models of IBD management. Conclusions: Optimising the setup of IBD units will require progressive leadership and willingness to challenge the status quo in order to provide better quality of care for our patients. IBD units are an important step towards harmonising care for IBD across Europe and for establishing standards for disease management programmes. PMID:25987349

Interactive graphical computer-aided design system

NASA Technical Reports Server (NTRS)

Edge, T. M.

1975-01-01

System is used for design, layout, and modification of large-scale-integrated (LSI) metal-oxide semiconductor (MOS) arrays. System is structured around small computer which provides real-time support for graphics storage display unit with keyboard, slave display unit, hard copy unit, and graphics tablet for designer/computer interface.

75 FR 27002 - Petitions for Modification

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

...,000 feet of the working face, which contain the Hubble Breathable Air Unit Emergency Supply Container, (``HBA Unit Emergency Supply Container''), and otherwise complying with all applicable provisions set forth in 30 CFR 75.1506(b) through (g). The HBA Unit Emergency Supply Container is a steel reinforced...

78 FR 14835 - Investigations: Terminations, Modifications and Rulings: Certain Consumer Electronics and Display...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-07

..., Modifications and Rulings: Certain Consumer Electronics and Display Devices and Products Containing Same AGENCY... the sale within the United States after importation of certain consumer electronics devices and..., Washington; LG Electronics, Inc. of Seoul, South Korea; LG Electronics, Mobilecomm U.S.A., Inc. of San Diego...

Modification of cellulose with succinic anhydride in TBAA/DMSO mixed solvent under catalyst-free conditions

USDA-ARS?s Scientific Manuscript database

Homogeneous modification of cellulose with succinic anhydride was performed in tetrabutylammonium acetate (TBAA)/dimethyl sulfoxide (DMSO) mixed solvent. The molar ratio of succinic anhydride (SA) to free hydroxyl groups in the anhydroglucose units (AGU) and TBAA dosage were investigated as paramete...

Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients.

PubMed

Tetteh, Raymond A; Nartey, Edmund T; Lartey, Margaret; Mantel-Teeuwisse, Aukje K; Leufkens, Hubert G M; Yankey, Barbara A; Dodoo, Alexander N O

2016-11-01

Patients initiated on highly active antiretroviral therapy (HAART) generally remain on medication indefinitely. A modification in the HAART regimen may become necessary because of possible acute or chronic toxicities, concomitant clinical conditions, development of virological failure or the advent of adverse drug events. The study documents adverse drug events of HIV-positive Ghanaian patients with HAART modifications. It also investigates the association between documented adverse drug events and HAART modification using an unmatched case-control study design. The study was conducted in the Fevers Unit of the Korle Bu Teaching Hospital and involved patients who attended the HIV Care Clinic between January 2004 and December 2009. Data from 298 modified therapy patients (cases) were compared with 298 continuing therapy patients (controls) who had been on treatment for at least 1 month before the end of study. Controls were sampled from the same database of a cohort of HIV-positive patients on HAART, at the time a case occurred, in terms of treatment initiation ±1 month. Data were obtained from patients' clinical folders and the HIV clinic database linked to the pharmacy database. The nature of the documented adverse drug events of the cases was described and the association between the documented adverse drug events and HAART modification was determined by logistic regression with reported odds ratios (ORs) and their 95 % confidence interval (CI). Among the 298 modified therapy patients sampled in this study, 52.7 % of them had at least one documented adverse drug event. The most documented adverse drug event was anaemia, recorded in 18.5 % of modified therapy patients, all of whom were on a zidovudine-based regimen. The presence of documented adverse drug events was significantly associated with HAART modification [adjusted OR = 2.71 (95 % CI 2.11-3.48), p < 0.001]. Among HIV patients on HAART, adverse drug events play a major role in treatment modification. Occurrence of adverse drug events may be used as a predictor for possible therapy modification. We recommend the institution of active pharmacovigilance in HIV treatment programmes as it permits the proper identification and characterisation of drug-related adverse events. This can help develop approaches towards their management and also justify therapy modifications.

Biomarker and Clinical Trial Design Support for Disease-Modifying Therapies: Report of a Survey of the EU/US: Alzheimer's Disease Task Force.

PubMed

Cummings, J; Fox, N; Vellas, B; Aisen, P; Shan, G

2018-01-01

Disease-modifying therapies are urgently needed for the treatment of Alzheimer's disease (AD). The European Union/United States (EU/US) Task Force represents a broad range of stakeholders including biopharma industry personnel, academicians, and regulatory authorities. The EU/US Task Force represents a community of knowledgeable individuals who can inform views of evidence supporting disease modification and the development of disease-modifying therapies (DMTs). We queried their attitudes toward clinical trial design and biomarkers in support of DMTs. A survey of members of the EU/US Alzheimer's Disease Task Force was conducted. Ninety-three members (87%) responded. The details were analyzed to understand what clinical trial design and biomarker data support disease modification. Task Force members favored the parallel group design compared to delayed start or staggered withdrawal clinical trial designs to support disease modification. Amyloid biomarkers were regarded as providing mild support for disease modification while tau biomarkers were regarded as providing moderate support. Combinations of biomarkers, particularly combinations of tau and neurodegeneration, were regarded as providing moderate to marked support for disease modification and combinations of all three classes of biomarkers were regarded by a majority as providing marked support for disease modification. Task Force members considered that evidence derived from clinical trials and biomarkers supports clinical meaningfulness of an intervention, and when combined with a single clinical trial outcome, nearly all regarded the clinical trial design or biomarker evidence as supportive of disease modification. A minority considered biomarker evidence by itself as indicative of disease modification in prevention trials. Levels of evidence (A,B,C) were constructed based on these observations. The survey indicates the view of knowledgeable stakeholders regarding evidence derived from clinical trial design and biomarkers in support of disease modification. Results of this survey can assist in designing clinical trials of DMTs.

High Efficiency Room Air Conditioner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bansal, Pradeep

This project was undertaken as a CRADA project between UT-Battelle and Geberal Electric Company and was funded by Department of Energy to design and develop of a high efficiency room air conditioner. A number of novel elements were investigated to improve the energy efficiency of a state-of-the-art WAC with base capacity of 10,000 BTU/h. One of the major modifications was made by downgrading its capacity from 10,000 BTU/hr to 8,000 BTU/hr by replacing the original compressor with a lower capacity (8,000 BTU/hr) but high efficiency compressor having an EER of 9.7 as compared with 9.3 of the original compressor. However,more » all heat exchangers from the original unit were retained to provide higher EER. The other subsequent major modifications included- (i) the AC fan motor was replaced by a brushless high efficiency ECM motor along with its fan housing, (ii) the capillary tube was replaced with a needle valve to better control the refrigerant flow and refrigerant set points, and (iii) the unit was tested with a drop-in environmentally friendly binary mixture of R32 (90% molar concentration)/R125 (10% molar concentration). The WAC was tested in the environmental chambers at ORNL as per the design rating conditions of AHAM/ASHRAE (Outdoor- 95F and 40%RH, Indoor- 80F, 51.5%RH). All these modifications resulted in enhancing the EER of the WAC by up to 25%.« less

Glycan Reader is improved to recognize most sugar types and chemical modifications in the Protein Data Bank.

PubMed

Park, Sang-Jun; Lee, Jumin; Patel, Dhilon S; Ma, Hongjing; Lee, Hui Sun; Jo, Sunhwan; Im, Wonpil

2017-10-01

Glycans play a central role in many essential biological processes. Glycan Reader was originally developed to simplify the reading of Protein Data Bank (PDB) files containing glycans through the automatic detection and annotation of sugars and glycosidic linkages between sugar units and to proteins, all based on atomic coordinates and connectivity information. Carbohydrates can have various chemical modifications at different positions, making their chemical space much diverse. Unfortunately, current PDB files do not provide exact annotations for most carbohydrate derivatives and more than 50% of PDB glycan chains have at least one carbohydrate derivative that could not be correctly recognized by the original Glycan Reader. Glycan Reader has been improved and now identifies most sugar types and chemical modifications (including various glycolipids) in the PDB, and both PDB and PDBx/mmCIF formats are supported. CHARMM-GUI Glycan Reader is updated to generate the simulation system and input of various glycoconjugates with most sugar types and chemical modifications. It also offers a new functionality to edit the glycan structures through addition/deletion/modification of glycosylation types, sugar types, chemical modifications, glycosidic linkages, and anomeric states. The simulation system and input files can be used for CHARMM, NAMD, GROMACS, AMBER, GENESIS, LAMMPS, Desmond, OpenMM, and CHARMM/OpenMM. Glycan Fragment Database in GlycanStructure.Org is also updated to provide an intuitive glycan sequence search tool for complex glycan structures with various chemical modifications in the PDB. http://www.charmm-gui.org/input/glycan and http://www.glycanstructure.org. wonpil@lehigh.edu. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Modification and fixed-point analysis of a Kalman filter for orientation estimation based on 9D inertial measurement unit data.

PubMed

Brückner, Hans-Peter; Spindeldreier, Christian; Blume, Holger

2013-01-01

A common approach for high accuracy sensor fusion based on 9D inertial measurement unit data is Kalman filtering. State of the art floating-point filter algorithms differ in their computational complexity nevertheless, real-time operation on a low-power microcontroller at high sampling rates is not possible. This work presents algorithmic modifications to reduce the computational demands of a two-step minimum order Kalman filter. Furthermore, the required bit-width of a fixed-point filter version is explored. For evaluation real-world data captured using an Xsens MTx inertial sensor is used. Changes in computational latency and orientation estimation accuracy due to the proposed algorithmic modifications and fixed-point number representation are evaluated in detail on a variety of processing platforms enabling on-board processing on wearable sensor platforms.

Procurement of a fully licensed radioisotope thermoelectric generator transportation system

NASA Astrophysics Data System (ADS)

Adkins, Harold E.; Bearden, Thomas E.

The present transportation system for radioisotope thermoelectric generators and heater units is being developed to comply with all applicable U.S. DOT regulations, including a doubly-contained 'bell jar' concept for the required double-containment of plutonium. Modifications in handling equipment and procedures are entailed by this novel packaging design, and will affect high-capacity forklifts, overhead cranes, He-backfilling equipment, etc. Attention is given to the design constraints involved, and to the Federal procurement process.

A Module Experimental Process System Development Unit (MEPSDU)

NASA Technical Reports Server (NTRS)

1982-01-01

Restructuring research objectives from a technical readiness demonstration program to an investigation of high risk, high payoff activities associated with producing photovoltaic modules using non-CZ sheet material is reported. Deletion of the module frame in favor of a frameless design, and modification in cell series parallel electrical interconnect configuration are reviewed. A baseline process sequence was identified for the fabrication of modules using the selected dendritic web sheet material, and economic evaluations of the sequence were completed.

Development and integration of a scalable low NOx combustion chamber for a hydrogen-fueled aerogas turbine

NASA Astrophysics Data System (ADS)

Boerner, S.; Funke, H. H.-W.; Hendrick, P.; Recker, E.; Elsing, R.

2013-03-01

The usage of alternative fuels in aircraft industry plays an important role of current aero engine research and development processes. The micromix burning principle allows a secure and low NOx combustion of gaseous hydrogen. The combustion principle is based on the fluid phenomenon of jet in cross flow and achieves a significant lowering in NOx formation by using multiple miniaturized flames. The paper highlights the development and the integration of a combustion chamber, based on the micromix combustion principle, into an Auxiliary Power Unit (APU) GTCP 36-300 with regard to the necessary modifications on the gas turbine and on the engine controller.

77 FR 31683 - Notice of Effective Date of Modifications to a Rule of Origin of the United States-Australia Free...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... Rule of Origin of the United States-Australia Free Trade Agreement AGENCY: Office of the United States... to a product-specific rule of origin under the United States-Australia Free Trade Agreement (USAFTA). SUMMARY: In Proclamation 8334 of December 31, 2008, the President modified the rules of origin for certain...

Climate control: United States weather modification in the cold war and beyond.

PubMed

Harper, Kristine C

2008-03-01

Rainmaking, hail busting, fog lifting, snowpack enhancing, lightning suppressing, hurricane snuffing...weather control. At the lunatic fringe of scientific discussion in the early twentieth century--and the subject of newspaper articles with tones ranging from skeptical titters to awestruck wonder--weather modification research became more serious after World War II. In the United States, the 'seeds' of silver iodide and dry ice purported to enhance rainfall and bust hailstorms soon became seeds of controversy from which sprouted attempts by federal, state and local government to control the controllers and exploit 'designer weather' for their own purposes.

Antibacterial Drug Releasing Materials by Post-Polymerization Surface Modification

NASA Astrophysics Data System (ADS)

Chng, Shuyun; Moloney, Mark G.; Wu, Linda Y. L.

Functional materials are available by the post-polymerization surface modification of diverse polymers in a three-step process mediated, firstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modification with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodified controls, and observable antibacterial biocidal activity.

37 CFR 5.5 - Permit to disclose or modification of secrecy order.

Code of Federal Regulations, 2011 CFR

2011-07-01

... consigned prior to being lodged in the foreign patent office. The petition should include a statement... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Permit to disclose or modification of secrecy order. 5.5 Section 5.5 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND...

19 CFR 210.76 - Modification or rescission of exclusion orders, cease and desist orders, and consent orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Modification or rescission of exclusion orders, cease and desist orders, and consent orders. 210.76 Section 210.76 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT...

37 CFR 5.5 - Permit to disclose or modification of secrecy order.

Code of Federal Regulations, 2012 CFR

2012-07-01

... consigned prior to being lodged in the foreign patent office. The petition should include a statement... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Permit to disclose or modification of secrecy order. 5.5 Section 5.5 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND...

37 CFR 5.5 - Permit to disclose or modification of secrecy order.

Code of Federal Regulations, 2013 CFR

2013-07-01

... consigned prior to being lodged in the foreign patent office. The petition should include a statement... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Permit to disclose or modification of secrecy order. 5.5 Section 5.5 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND...

37 CFR 5.5 - Permit to disclose or modification of secrecy order.

Code of Federal Regulations, 2014 CFR

2014-07-01

... consigned prior to being lodged in the foreign patent office. The petition should include a statement... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Permit to disclose or modification of secrecy order. 5.5 Section 5.5 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND...

Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions.

PubMed

Claeys, Bart; De Coen, Ruben; De Geest, Bruno G; de la Rosa, Victor R; Hoogenboom, Richard; Carleer, Robert; Adriaensens, Peter; Remon, Jean Paul; Vervaet, Chris

2013-11-01

Polymethacrylates such as Eudragit® polymers are well established as drug delivery matrix. Here, we synthesize several Eudragit E PO (n-butyl-, dimethylaminoethyl-, methyl-methacrylate-terpolymer) analogues via free radical polymerization. These polymers are processed via hot melt extrusion, followed by injection molding and evaluated as carriers to produce immediate release solid solution tablets. Three chemical modifications increased the glass transition temperature of the polymer: (a) substitution of n-butyl by t-butyl groups, (b) reduction of the dimethylaminoethyl methacrylate (DMAEMA) content, and (c) incorporation of a bulky isobornyl repeating unit. These structural modifications revealed the possibility to increase the mechanical stability of the tablets via altering the polymer Tg without influencing the drug release characteristics and glassy solid solution forming properties. The presence of DMAEMA units proved to be crucial with respect to API/polymer interaction (essential in creating glassy solid solutions) and drug release characteristics. Moreover, these chemical modifications accentuate the need for a more rational design of (methacrylate) polymer matrix excipients for drug formulation via hot melt extrusion and injection molding. Copyright © 2013 Elsevier B.V. All rights reserved.

Emergence of a scientific and commercial research and development infrastructure for human gene therapy.

PubMed

Crofts, Christine; Krimsky, Sheldon

2005-02-01

A research and clinical subfield known as "human gene therapy" has grown rapidly since 1990, when the first human trials were approved in the United States. Using quantitative data, this paper describes and analyzes the research and commercial infrastructure, including academic centers, publications, intellectual property, and biotechnology firms, that has developed around the goal of discovering clinical applications for the modification and transport of DNA to somatic cells. Despite setbacks and few documented successes, the subfield of human gene therapy continues to serve as an influential clinical paradigm for the treatment of inherited and noninherited diseases.

KSC-05pd2533

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility Bay 2, United Space Alliance technician Michael Vanwart installs thermal protection system blankets in the nose cap of space shuttle Endeavour. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

KSC-05pd2531

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility bay 2, United Space Alliance technician Michael Vanwart prepares to install thermal protection system blankets in the nose cap of space shuttle Endeavour. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

KSC-05pd2532

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility Bay 2, United Space Alliance technician Michael Vanwart installs thermal protection system blankets in the nose cap of space shuttle Endeavour. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

78 FR 53239 - Establishment, Modification and Cancellation of Air Traffic Service (ATS) Routes; Northeast...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... Traffic Service (ATS) Routes; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT... northeast United States. This action is necessary due to the decommissioning of the Lake Henry, PA, VHF... navigation (RNAV) routes; and cancel two VOR Federal airways in the northeast United States (78 FR 38236...

16 CFR 305.10 - Ranges of comparability on the required labels.

Code of Federal Regulations, 2013 CFR

2013-01-01

... modification under this section need not be relabeled. (b) Representative average unit energy cost. The Representative Average Unit Energy Cost to be used on labels as required by § 305.11 and disclosures as required... Representative Average Unit Energy Cost figures every five years beginning in 2012 in the Federal Register. When...

16 CFR 305.10 - Ranges of comparability on the required labels.

Code of Federal Regulations, 2010 CFR

2010-01-01

... modification under this section need not be relabeled. (b) Representative average unit energy cost. The Representative Average Unit Energy Cost to be used on labels as required by § 305.11 and disclosures as required... Representative Average Unit Energy Cost figures every five years beginning in 2012 in the Federal Register. When...

16 CFR 305.10 - Ranges of comparability on the required labels.

Code of Federal Regulations, 2012 CFR

2012-01-01

... modification under this section need not be relabeled. (b) Representative average unit energy cost. The Representative Average Unit Energy Cost to be used on labels as required by § 305.11 and disclosures as required... Representative Average Unit Energy Cost figures every five years beginning in 2012 in the Federal Register. When...

16 CFR 305.10 - Ranges of comparability on the required labels.

Code of Federal Regulations, 2011 CFR

2011-01-01

... modification under this section need not be relabeled. (b) Representative average unit energy cost. The Representative Average Unit Energy Cost to be used on labels as required by § 305.11 and disclosures as required... Representative Average Unit Energy Cost figures every five years beginning in 2012 in the Federal Register. When...

Demonstration of a Large-Scale Tank Assembly via Circumferential Friction Stir Welds

NASA Technical Reports Server (NTRS)

Jones, Clyde S.; Adams, Glynn; Colligan, Kevin

2000-01-01

A collaborative effort between NASA/Marshall Space Flight Center and the Michoud Unit of Lockheed Martin Space Systems Company was undertaken to demonstrate assembly of a large-scale aluminum tank using circumferential friction stir welds. The hardware used to complete this demonstration was fabricated as a study of near-net- shape technologies. The tooling used to complete this demonstration was originally designed for assembly of a tank using fusion weld processes. This presentation describes the modifications and additions that were made to the existing fusion welding tools required to accommodate circumferential friction stir welding, as well as the process used to assemble the tank. The tooling modifications include design, fabrication and installation of several components. The most significant components include a friction stir weld unit with adjustable pin length capabilities, a continuous internal anvil for 'open' circumferential welds, a continuous closeout anvil, clamping systems, an external reaction system and the control system required to conduct the friction stir welds and integrate the operation of the tool. The demonstration was intended as a development task. The experience gained during each circumferential weld was applied to improve subsequent welds. Both constant and tapered thickness 14-foot diameter circumferential welds were successfully demonstrated.

Proposal for Creating a Pocket of Innovation and Adaptability Within a Bureaucratic Enterprise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nichols, T. T.; Millet, C. B.

2001-07-02

A conceptual framework is developed that is based on a behavioral model for organizations that rely upon innovation and adaptability for their survival in the market place. The model supports the assertion that change efforts aimed at performance improvement need a systems approach because contributions to an organization's performance cross functional lines and are systemic in nature. The model implies four conclusions for a unit trying to effectuate change within a greater bureaucracy. First, the desired behaviors are currently neither evaluated nor rewarded enough by either the enterprise or the local unit. Second, the model has to be applied tomore » the local unit, treating the unit as a distinct enterprise itself. Third, a misalignment between the unit's new form and that of the rest of the enterprise will invariably be created. Fourth, this misalignment has to be minimized enough by the local unit to avoid the larger enterprise from responding negatively to the change effort. The mode l results in a change approach that constrains localized behavior modification by the need to remain aligned with the overall structure of the complete enterprise. The conceptual framework is used to develop a proposal for effectuating behavioral change within the High-Level Waste (HLW) Program at the Idaho National Engineering and Environmental Laboratory (INEEL). A ''strawman'' involving a set of critical systems, performance and evaluation measures, and tactics is presented as a starting point for further discussion and development within the Program organization.« less

Proposal for Creating a Pocket of Innovation & Adaptability within a Bureaucratic Enterprise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nichols, Todd Travis; Millet, C. D.

2001-07-01

A conceptual framework is developed that is based on a behavioral model for organizations that rely upon innovation and adaptability for their survival in the market place. The model supports the assertion that change efforts aimed at performance improvement need a systems approach because contributions to an organization's performance cross functional lines and are systemic in nature. The model implies four conclusions for a unit trying to effectuate change within a greater bureaucracy. First, the desired behaviors are currently neither evaluated nor rewarded enough by either the enterprise or the local unit. Second, the model has to be applied tomore » the local unit, treating the unit as a distinct enterprise itself. Third, a misalignment between the unit's new form and that of the rest of the enterprise will invariably be created. Fourth, this misalignment has to be minimized enough by the local unit to avoid the larger enterprise from responding negatively to the change effort. The model results in a change approach that constrains localized behavior modification by the need to remain aligned with the overall structure of the complete enterprise. The conceptual framework is used to develop a proposal for effectuating behavioral change within the High-Level Waste (HLW) Program at the Idaho National Engineering and Environmental Laboratory (INEEL). A "strawman" involving a set of critical systems, performance and evaluation measures, and tactics is presented as a starting point for further discussion and development within the Program organization.« less

Addendum to the Closure Report for Corrective Action Unit 271: Areas 25, 26, and 27 Septic Systems Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the August 2004, Closure Report for Corrective Action Unit 271, Areas 25, 26, and 27 Septic Systems as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consistsmore » of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the modification of the UR for CAS 27-05-02, Leachfield. This UR was established as part of a Federal Facility Agreement and Consent Order (FFACO) corrective action and is based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to modify the UR to an administrative UR. Administrative URs differ from standard URs in that they do not require onsite postings (i.e., signs) or other physical barriers (e.g., fencing, monuments), and they do not require periodic inspections (see Section 6.2 of the Industrial Sites Project Establishment of Final Action Levels [NNSA/NSO, 2006c]). This Administrative UR was based on an “Occasional Use Area” future land use scenario that was used to calculate the FAL. The administrative UR will protect workers from an exposure exceeding that used in the calculation of the FAL (i.e., 400 total work hours). Any proposed activity within this use restricted area that would potentially cause an exposure exceeding this exposure limit would require approval from the Nevada Division of Environmental Protection (NDEP). Requirements for inspecting and maintaining postings at this UR will be canceled, and the postings and signage at this site will be removed. Fencing and posting may be present at this site that are unrelated to the FFACO UR such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at this site.« less

Transforming a Traditional Inquiry-Based Science Unit into a STEM Unit for Elementary Pre-service Teachers: A View from the Trenches

NASA Astrophysics Data System (ADS)

Schmidt, Matthew; Fulton, Lori

2016-04-01

The need to prepare students with twenty-first-century skills through STEM-related teaching is strong, especially at the elementary level. However, most teacher education preparation programs do not focus on STEM education. In an attempt to provide an exemplary model of a STEM unit, we used a rapid prototyping approach to transform an inquiry-based unit on moon phases into one that integrated technology in a meaningful manner to develop technological literacy and scientific concepts for pre-service teachers (PSTs). Using qualitative case study methodology, we describe lessons learned related to the development and implementation of a STEM unit in an undergraduate elementary methods course, focusing on the impact the inquiry model had on PSTs' perceptions of inquiry-based science instruction and how the integration of technology impacted their learning experience. Using field notes and survey data, we uncovered three overarching themes. First, we found that PSTs held absolutist beliefs and had a need for instruction on inquiry-based learning and teaching. Second, we determined that explicit examples of effective and ineffective technology use are needed to help PSTs develop an understanding of meaningful technology integration. Finally, the rapid prototyping approach resulted in a successful modification of the unit, but caused the usability of our digital instructional materials to suffer. Our findings suggest that while inquiry-based STEM units can be implemented in existing programs, creating and testing these prototypes requires significant effort to meet PSTs' learning needs, and that iterating designs is essential to successful implementation.

An Analysis of Attendance Patterns in the Experimental Food Service System at Travis Air Force Base

DTIC Science & Technology

1974-12-01

Food Service System Study was undertaken to develop wideranging improvements in current Air Force food service operations. Of particular concern was the need to increase consumer attendance and utilization of the dining facilities. A number of changes were implemented during the experiment including menu modifications, dining hall renovations, and the introduction of three new food service operations - a modular fast food unit, a flight line facility, and an ethnic, specialty meal service provided by one of the renovated dining

Composite casting/bonding construction of an air-cooled, high temperature radial turbine wheel

NASA Technical Reports Server (NTRS)

Hammer, A. N.; Aigret, G.; Rodgers, C.; Metcalfe, A. G.

1983-01-01

A composite casting/bonding technique has been developed for the fabrication of a unique air-cooled, high temperature radial inflow turbine wheel design applicable to auxilliary power units with small rotor diameters and blade entry heights. The 'split blade' manufacturing procedure employed is an alternative to complex internal ceramic coring. Attention is given to both aerothermodynamic and structural design, of which the latter made advantageous use of the exploration of alternative cooling passage configurations through CAD/CAM system software modification.

Korean immigrant women's lived experience of childbirth in the United States.

PubMed

Seo, Jin Young; Kim, Wooksoo; Dickerson, Suzanne S

2014-01-01

To understand Korean immigrant women's common experiences and practices of utilizing health care services in the United States during childbirth. A qualitative interpretive phenomenological research design. Recruitment was conducted through advertisement on the MissyUSA.com website, which is the largest online community for married Korean women who live in North America. A purposive sample of 15 Korean immigrant women who experienced childbirth in the United States within the past 5 years was recruited. Data were collected using semistructured telephone interviews and were analyzed using the Heideggerian hermeneutical methodology. During childbirth in the United States, participants faced multifaceted barriers in unfamiliar sociocultural contexts yet maintained their own cultural heritages. They navigated the unfamiliar health care system and developed their own strategies to overcome barriers to health care access. Korean immigrant women actively sought health information on the Internet and through social networking during childbirth. Korean immigrant women selectively accepted new cultural beliefs with some modifications from their own cultural contexts and developed their own distinct birth cultures. Understanding a particular culture and respecting women's traditions, beliefs, and practices about their childbirth could help nurses to provide culturally sensitive care. © 2014 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

40 CFR 52.2454 - Prevention of significant deterioration of air quality for Merck & Co., Inc.'s Stonewall Plant in...

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Significant modifications for the purposes of this section are defined as changes to an existing process unit... responsible official that to his belief, based on reasonable inquiry, the information submitted in the report.... (1) Permit modifications that require public participation. For any change that does not meet the...

78 FR 65570 - Modification of Significant New Uses of 1-Propene, 2,3,3,3-tetrafluoro-

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-01

... include, but are not limited to: Manufacturers or processors of the subject chemical substance (NAICS... by this action. Other types of entities not listed in this unit could also be affected. The North... modification. One of the commenters also noted a potential ambiguity in the proposed regulatory text. Part of...

Modification of cellulose with succinic anhydride in TBAA/DMSO mixed solvent under catalyst-free conditions

Treesearch

Ping-Ping Xin; Yao-Bing Huang; Chung-Yun Hse; Huai N. Cheng; Chaobo Huang; Hui Pan

2017-01-01

Homogeneous modification of cellulose with succinic anhydride was performed using tetrabutylammonium acetate (TBAA)/dimethyl sulfoxide (DMSO) mixed solvent. The molar ratio of succinic anhydride (SA) to free hydroxyl groups in the anhydroglucose units (AGU), TBAA dosage, reaction temperature, and reaction time were investigated. The highest degree of substitution (DS)...

75 FR 53871 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Modification of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-02

...; Modification of the Common Pool Day-at-Sea Accounting and Possession Prohibition for Witch Flounder AGENCY... fishing under common pool regulations for the 2010 fishing year (FY) when fishing in the Inshore Gulf of... exceed the subcomponent of the annual catch limit (ACL) allocated to the common pool during FY 2010 (May...

Fuelbreaks and other fuel modification for wildland fire control

Treesearch

Lisle Green

1977-01-01

In Mediterranean climates, the shrubby plant cover and the coniferous forest above it are vulnerable to frequent large fires. The fuelbreak, a strip of land in a strategic area-such as a ridgetop-where fuel modification and often type conversion can be accomplished, is an approach to fire suppression being widely applied in the Western United States, particularly...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Prior to 1978, the Wilsonville Advanced Coal Liquefaction facility material balance surrounded only the thermal liquefaction unit and involved analyses of only the slurry stream and individual gas streams. The distillate solvent yield was determined by difference. Subsequently, several modifications and additional process units were introduced to this single unit system. With the inclusion of the deashing unit in 1978 and the catalytic hydrogenation unit in 1981, the process has evolved into a sophisticated two-stage coal liquefaction process and has the potential for various modes of integration. This report presents an elemental balancing procedure and a simplified presentation format thatmore » is sufficiently flexible to meet current and future needs. The development of the elemental balancing technique and the relevant computer programs to handle the calculations have been addressed. This will be useful in modelling individual unit performance as well as determining the impact of each unit on the overall liquefaction system, provided the units are on a steady-state basis. Five different material balance envelopes are defined. Three of these envelopes pertain to the individual units (the thermal liquefaction or TL unit, the Critical Solvent Deashing or CSD unit and the H-Oil Ebullated Bed Hydrotreating or HTR unit). The fourth or single stage material balance envelope combines the TL and CSD units. The fifth envelope is the two-stage configuration combining all three units. 3 references.« less

Periscopic Spine Surgery.

DTIC Science & Technology

2000-02-01

radiation medicine, the neurosurgery intensive care unit (ICU), and the pediatrics ICU [Geary 1999a]. The major procedures impacted are spine tumor...radiation medicine, and the pediatric intensive care unit . Hardware and software problems addressed included modifications of patient positioning...planning. Attempts have been made to link mechanical tissue properties to cellular interaction through electrical impedance [7] and to Hounsfield units

75 FR 68153 - To Adjust the Rules of Origin Under the United States-Bahrain Free Trade Agreement, Implement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-04

... Part IV The President Proclamation 8596--To Adjust the Rules of Origin Under the United States... Adjust the Rules of Origin Under the United States-Bahrain Free Trade Agreement, Implement Modifications... the HTS the schedule of duty reductions and rules of origin necessary or appropriate to carry out the...

77 FR 59241 - Notice of Effective Date of Modifications to Certain Textile and Apparel Rules of Origin of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-26

... Rules of Origin of the Dominican Republic-Central America- United States Free Trade Agreement AGENCY... Certain Textile and Apparel Rules of Origin of the Dominican Republic-Central America- United States Free...- Central America-United States Free Trade Agreement Implementation Act (the ``CAFTA-DR Act'') approved the...

The Aquarium: A Marine Education Infusion Unit. Northern New England Marine Education Project.

ERIC Educational Resources Information Center

Maine Univ., Orono. Coll. of Education.

This interdisciplinary unit is intended for use in second grade classes; however, it can be used K-8 with modifications. The unit seeks to demonstrate that aquatic organisms interact in complex ecosystems and that these organisms react to their environment in different ways. Specific directions are given for setting up an aquarium and populating…

Subscale Water Based Phase Change Material Heat Exchanger Development

NASA Technical Reports Server (NTRS)

Sheth, Rubik; Hansen, Scott

2016-01-01

Supplemental heat rejection devices are required in many spacecraft as the radiators are not sized to meet the full heat rejection demand. One means of obtaining additional heat rejection is through the use of phase change material heat exchangers (PCM HX's). PCM HX's utilize phase change to store energy in unfavorable thermal environments (melting) and reject the energy in favorable environments (freezing). Traditionally, wax has been used as a PCM on spacecraft. However, water is an attractive alternative because it is capable of storing about 40% more energy per unit mass due to its higher latent heat of fusion. The significant problem in using water as a PCM is its expansion while freezing, leading to structural integrity concerns when housed in an enclosed heat exchanger volume. Significant investigation and development has taken place over the past five years to understand and overcome the problems associated with water PCM HX's. This paper reports on the final efforts by Johnson Space Center's Thermal Systems Branch to develop a water based PCM HX. The test article developed and reported on is a subscale version of the full-scale water-based PCM HX's constructed by Mezzo Technologies. The subscale unit was designed by applying prior research on freeze front propagation and previous full-scale water PCM HX development. Design modifications to the subscale unit included use of urethane bladder, decreased aspect ratio, perforated protection sheet, and use of additional mid-plates. Testing of the subscale unit was successful and 150 cycles were completed without fail.

Severely deranged vital signs as triggers for acute treatment modifications on an intensive care unit in a low-income country.

PubMed

Schell, Carl Otto; Castegren, Markus; Lugazia, Edwin; Blixt, Jonas; Mulungu, Moses; Konrad, David; Baker, Tim

2015-07-25

Critical care saves lives of the young with reversible disease. Little is known about critical care services in low-income countries. In a setting with a shortage of doctors the actions of the nurse bedside are likely to have a major impact on the outcome of critically ill patients with rapidly changing physiology. Identification of severely deranged vital signs and subsequent treatment modifications are the basis of modern routines in critical care, for example goal directed therapy and rapid response teams. This study assesses how often severely deranged vital signs trigger an acute treatment modification on an Intensive Care Unit (ICU) in Tanzania. A medical records based, observational study. Vital signs (conscious level, respiratory rate, oxygen saturation, heart rate and systolic blood pressure) were collected as repeated point prevalences three times per day in a 1-month period for all adult patients on the ICU. Severely deranged vital signs were identified and treatment modifications within 1 h were noted. Of 615 vital signs studied, 126 (18%) were severely deranged. An acute treatment modification was in total indicated in 53 situations and was carried out three times (6%) (2/32 for hypotension, 0/8 for tachypnoea, 1/6 for tachycardia, 0/4 for unconsciousness and 0/3 for hypoxia). This study suggests that severely deranged vital signs are common and infrequently lead to acute treatment modifications on an ICU in a low-income country. There may be potential to improve outcome if nurses are guided to administer acute treatment modifications by using a vital sign directed approach. A prospective study of a vital sign directed therapy protocol is underway.

In situ lignocellulosic unlocking mechanism for carbohydrate hydrolysis in termites: crucial lignin modification

PubMed Central

2011-01-01

Background Termites are highly effective at degrading lignocelluloses, and thus can be used as a model for studying plant cell-wall degradation in biological systems. However, the process of lignin deconstruction and/or degradation in termites is still not well understood. Methods We investigated the associated structural modification caused by termites in the lignin biomolecular assembly in softwood tissues crucial for cell-wall degradation. We conducted comparative studies on the termite-digested (i.e. termite feces) and native (control) softwood tissues with the aid of advanced analytical techniques: 13C crosspolarization magic angle spinning and nuclear magnetic resonance (CP-MAS-NMR) spectroscopy, flash pyrolysis with gas chromatography mass spectrometry (Py-GC/MS), and Py-GC-MS in the presence of tetramethylammonium hydroxide (Py-TMAH)-GC/MS. Results The 13C CP/MAS NMR spectroscopic analysis revealed an increased level of guaiacyl-derived (G unit) polymeric framework in the termite-digested softwood (feces), while providing specific evidence of cellulose degradation. The Py-GC/MS data were in agreement with the 13C CP/MAS NMR spectroscopic studies, thus indicating dehydroxylation and modification of selective intermonomer side-chain linkages in the lignin in the termite feces. Moreover, Py-TMAH-GC/MS analysis showed significant differences in the product distribution between control and termite feces. This strongly suggests that the structural modification in lignin could be associated with the formation of additional condensed interunit linkages. Conclusion Collectively, these data further establish: 1) that the major β-O-4' (β-aryl ether) was conserved, albeit with substructure degeneracy, and 2) that the nature of the resulting polymer in termite feces retained most of its original aromatic moieties (G unit-derived). Overall, these results provide insight into lignin-unlocking mechanisms for understanding plant cell-wall deconstruction, which could be useful in development of new enzymatic pretreatment processes mimicking the termite system for biochemical conversion of lignocellulosic biomass to fuels and chemicals. PMID:21672247

First results from quality assurance testing of MaPMTs for the LHCb RICH upgrade

NASA Astrophysics Data System (ADS)

Gambetta, S.; LHCb RICH Collaboration

2017-12-01

In 2019 the LHCb RICH detector will be upgraded to increase the read out rate from 1 MHz to 40 MHz. As a consequence, the current Hybrid Photon Detectors will have to be replaced. Multi-anode Photomultiplier Tubes (MaPMTs) from Hamamatsu with 64-channels will be used: the 1-in. R13742 and the 2-in. R13743 MaPMTs (custom modifications of the MaPMTs R11625 and R12699). Quality assurance testing of these MaPMTs using custom-developed readout electronics has started. We present the design and realisation of the test facilities to ensure consistency in testing and validation. A total of 3100 units of the R13742 and 450 units of the R13743 will be tested requiring high efficiency and reliability from the test stations. We report on the test programme and protocols, characterising the units and assuring compliance with specifications. First results of testing and detector characterisation will be presented, based on the pre-series production, comprising 54 units of R13742 and 20 units of R13743.

Health care-associated infections in Iran: A national update for the year 2015.

PubMed

Eshrati, Babak; Masoumi Asl, Hossein; Afhami, Shirin; Pezeshki, Zahra; Seifi, Arash

2018-06-01

A national surveillance system for health care-associated infections (HAIs) in Iran is relatively new, and an update on incidence and mortality rates can aid clinicians and stakeholders in development of new guidelines and imperative modifications to be made. Data were extracted from the national HAIs surveillance software for more than 7 million hospitalizations during 2015. Data regarding age, gender, deaths, ward of admission, and microbiologic findings were collected and analyzed. From 491 hospitals, 7,018,393 hospitalizations were reported during 2015; 82,950 patients had been diagnosed with at least 1 HAI, 6,355 of whom died (crude fatality rate, 7.7). Men comprised 51.4% of the patients. The incidence rate was calculated to be 1.18. Urinary tract infections and pneumonia were the most commonly reported infections (27.9% and 23.8%) and 33% of patients were older than age 65 years. Intensive care units had the highest incidence rates, followed by burn units with incidence rates close to 9. Highest percentages of deaths were reported among patients with an HAI in the intensive care unit (20.6%) and those with pneumonia (39.6%). Although the underreporting of HAIs hinders accurate calculation of incidence, the present study provides a general update. The results can help in modification of national guidelines and appropriate choice of antimicrobial agents in the management of HAIs. Copyright © 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Development of a solar powered residential air conditioner (General optimization)

NASA Technical Reports Server (NTRS)

Lowen, D. J.

1976-01-01

A commercially available 3-ton residential Lithium Bromide (LiBr) absorption air conditioner was modified for use with lower temperature solar heated water. The modification included removal of components such as the generator, concentration control chamber, liquid trap, and separator; and the addition of a Chrysler designed generator, an off-the-shelf LiBr-solution pump. The design goal of the modified unit was to operate with water as the heat-transfer fluid at a target temperature of 85 C (185 F), 29.4 C (85 F) cooling water inlet, producing 10.5 kW (3 tons) of cooling. Tests were performed on the system before and after modification to provide comparative data. At elevated temperatures (96 C, 205 F), the test results show that Lithium Bromide was carried into the condenser due to the extremely violent boiling and degraded the evaporator performance.

pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications.

PubMed

Vega-Chacón, Jaime; Arbeláez, María Isabel Amaya; Jorge, Janaina Habib; Marques, Rodrigo Fernando C; Jafelicci, Miguel

2017-08-01

A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe 3 O 4 ) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel. The surface modification in each step was confirmed by DRIFTS, TEM and zeta potential measurements. The hydrodynamic diameter of the nanosystems decreases as the pH value decreases. The nanosystems showed high colloidal stability in water and no cytotoxicity was detected, which make these nanosystems suitable for biomedical applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Direct runoff assessment using modified SME method in catchments in the Upper Vistula River Basin

NASA Astrophysics Data System (ADS)

Wałęga, A.; Rutkowska, A.; Grzebinoga, M.

2017-04-01

Correct determination of direct runoff is crucial for proper and safe dimensioning of hydroengineering structures. It is commonly assessed using SCS-CN method developed in the United States. However, due to deficiencies of this method, many improvements and modifications have been proposed. In this paper, a modified Sahu-Mishra-Eldo (SME) method was introduced and tested for three catchments located in the upper Vistula basin. Modification of SME method involved a determination of maximum potential retention S based on CN parameter derived from SCS-CN method. The modified SME method yielded direct runoff values very similar to those observed in the investigated catchments. Moreover, it generated significantly smaller errors in the direct runoff estimation as compared with SCS-CN and SME methods in the analyzed catchments. This approach may be used for estimating the runoff in uncontrolled catchments.

77 FR 27804 - Entergy Operations, Inc.; Grand Gulf Nuclear Station, Unit 1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... modification to the auxiliary cooling tower and the addition of two 60-gallon lube oil tanks associated with... modification of the auxiliary cooling tower and the addition of two 60-gallon lube oil tanks for the new radial... Mississippi River water is the Southeast Wood Fiber company located at the Claiborne County Port facility, 0.8...

Development and initial validation of the Swedish Family Satisfaction Intensive Care Questionnaire (SFS-ICQ).

PubMed

Thermaenius, Johan; Schandl, Anna; Sluys, Kerstin Prignitz

2018-06-20

Measuring patients satisfaction is an important part of continuous quality improvement in health care. In intensive care, family satisfaction is often used as a proxy for patient experience. At present, no suitable instrument to measure this has been fully validated in Sweden. The purpose of this study was to develop and validate a questionnaire intended to evaluate families' satisfaction of quality of care in Swedish intensive care units. Based on literature and the modification of pertinent items in two existing North American questionnaires, a Swedish questionnaire was developed. Content validity was assessed by experts, and the cognitive method Think Aloud was used with twelve family members of intensive care patients in two different intensive care units. Data was analysed using qualitative content analysis. Seven items in the questionnaire were identified as problematic, causing eight problems concerning questioning of content and 23 concerning misunderstanding. Six of these items were changed in order to be understood the way they were intended, and one item was removed. A family satisfaction questionnaire applicable in Swedish intensive care units has been developed and validated for respondents' understanding of the questions being asked. However, further psychometric testing should be performed when more data are available. Copyright © 2018 Elsevier Ltd. All rights reserved.

75 FR 14629 - Notice of Lodging of Second Modification to Consent Decree Under Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

... case of United States, et al. v. Marathon Ashland Petroleum LLC, Civil Action No. 01-40119 (PVG), was..., DC 20044-7611, and should refer to United States, et al. v. Marathon Ashland Petroleum LLC, D.J. Ref...

40 CFR 60.100 - Applicability, designation of affected facility, and reconstruction.

Code of Federal Regulations, 2013 CFR

2013-07-01

... petroleum refineries: fluid catalytic cracking unit catalyst regenerators, fuel gas combustion devices, and... petroleum refinery. (b) Any fluid catalytic cracking unit catalyst regenerator or fuel gas combustion device... regenerator under paragraph (b) of this section which commences construction, reconstruction, or modification...

40 CFR 60.100 - Applicability, designation of affected facility, and reconstruction.

Code of Federal Regulations, 2014 CFR

2014-07-01

... petroleum refineries: fluid catalytic cracking unit catalyst regenerators, fuel gas combustion devices, and... petroleum refinery. (b) Any fluid catalytic cracking unit catalyst regenerator or fuel gas combustion device... regenerator under paragraph (b) of this section which commences construction, reconstruction, or modification...

Effect of radiation light characteristics on surface hardness of paint-on resin for shade modification.

PubMed

Arikawa, Hiroyuki; Kanie, Takahito; Fujii, Koichi; Ban, Seiji

2005-12-01

The purpose of this study was to investigate the effect of radiation light characteristics--of different types of clinical light-curing unit--on polymerization efficiency, as determined by the surface hardness of light-cured paint-on resins. Four shades of paint-on resin for shade modification of restorative resins were used. Materials were cured using one laboratory and three clinical light-curing units with different light sources, namely tungsten-halogen, LED, plasma arc, and xenon flash lamps. Knoop hardness measurements were taken at both the top and bottom surfaces of the specimens to assess the mechanical properties and degree of polymerization. Both LED and plasma arc light units caused significantly poorer surface hardness than the halogen and laboratory xenon lights. In addition, the transparent shade was more sensitive to surface hardness than other chromatic shades. Our results indicated that the polymerization efficiency of paint-on resin was significantly influenced by the radiation light characteristics of clinical light-curing units.

Advance information on the supply of pulpwood in survey unit #1

Treesearch

L.F. Eldredge; Southern Forest Survey Staff

1935-01-01

This report presents information concerning the quantity of pulpwood in survey unit #1, Florida. The geographic location of this unit which includes twenty-one counties in the northeastern part of the state is shown in Figure 1. The boundary of the Ocala National Forest. The data given in this release are preliminary and are subject to correction and modification when...

43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

Code of Federal Regulations, 2012 CFR

2012-10-01

... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

Code of Federal Regulations, 2013 CFR

2013-10-01

... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

Code of Federal Regulations, 2014 CFR

2014-10-01

... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

Addendum to the Closure Report for Corrective Action Unit 355: Area 2 Cellars/Mud Pits Nevada Test Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the November 2003, Closure Report for Corrective Action Unit 355: Area 2 Cellars/Mud Pits as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, this addendum consists of: • Thismore » cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS 02-37-01, Cellar & Mud Pit • CAS 02-37-03, Cellar & Mud Pit • CAS 02-37-04, Cellar & Mud Pit • CAS 02-37-05, Cellar & Mud Pit • CAS 02-37-06, Cellar & Mud Pit • CAS 02-37-07, Cellar & Mud Pit • CAS 02-37-10, Cellar & Mud Pit • CAS 02-37-11, Cellar & Mud Pit • CAS 02-37-12, Cellar & Mud Pit • CAS 02-37-13, Cellar & Mud Pit • CAS 02-37-14, Cellar & Mud Pit • CAS 02-37-15, Cellar & Mud Pit • CAS 02-37-16, Cellar & Mud Pit • CAS 02-37-17, Cellar • CAS 02-37-18, Cellar & Tanks These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to remove these URs because contamination is not present at these sites above the risk-based FALs. Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Status of Hollow Cathode Heater Development for the Space Station Plasma Contactor

NASA Technical Reports Server (NTRS)

Soulas, George C.

1994-01-01

A hollow cathode-based plasma contactor has been selected for use on the Space Station. During the operation of the plasma contactor, the hollow cathode heater will endure approximately 12000 thermal cycles. Since a hollow cathode heater failure would result in a plasma contactor failure, a hollow cathode heater development program was established to produce a reliable heater. The development program includes the heater design, process documents for both heater fabrication and assembly, and heater testing. The heater design was a modification of a sheathed ion thruster cathode heater. Heater tests included testing of the heater unit alone and plasma contactor and ion thruster testing. To date, eight heaters have been or are being processed through heater unit testing, two through plasma contactor testing and three through ion thruster testing, all using direct current power supplies. Comparisons of data from heater unit performance tests before cyclic testing, plasma contactor tests, and ion thruster tests at the ignition input current level show the average deviation of input power and tube temperature near the cathode tip to be +/-0.9 W and +/- 21 C, respectively. Heater unit testing included cyclic testing to evaluate reliability under thermal cycling. The first heater, although damaged during assembly, completed 5985 ignition cycles before failing. Four additional heaters successfully completed 6300, 6300, 700, and 700 cycles. Heater unit testing is currently ongoing for three heaters which have to date accumulated greater than 7250, greater than 5500, and greater than 5500 cycles, respectively.

Status of the Development of Flight Power Processing Units for the NASAs Evolutionary Xenon Thruster - Commercial (NEXT-C) Project

NASA Technical Reports Server (NTRS)

Aulisio, Michael V.; Pinero, Luis R.; White, Brandon L.; Hickman, Tyler A.; Bontempo, James J.; Hertel, Thomas A.; Birchenough, Arthur G.

2016-01-01

A pathfinder prototype unit and two flight power processing units (PPUs) are being developed by the Aerojet Rocketdyne Corporation in Redmond, Washington and ZIN Technologies in Cleveland, Ohio, in support of the NEXT-C Project. This project is being led by the NASA Glenn Research Center in Cleveland, Ohio, and will also yield two flight thrusters. This hardware is being considered to be provided as Government Furnished Equipment for the New Frontiers Program, and is applicable to a variety of planetary science missions and astrophysics science missions. The design of the NEXT-C PPU evolves from the hardware fabricated under the NEXT technology development project. The power processing unit operates from two sources: a wide input 80 to 160 V high-power bus and a nominal 28 V low-power bus. The unit includes six power supplies. Four power supplies (beam, accelerator, discharge, and neutralizer keeper) are needed for steady state operation, while two cathode heater power supplies (neutralizer and discharge) are utilized during thruster startup. The unit in total delivers up to 7 kW of regulated power to a single gridded-ion thruster. Significant modifications to the initial design include: high-power adaptive-delay control, upgrade of design to EEE-INST-002 compliance, telemetry accuracy improvements, incorporation of telemetry to detect plume-mode operation, and simplification of the design in select areas to improve manufacturability and commercialization potential. The project is presently in the prototype phase and preparing for qualification level environmental testing.

Modification of the Ames 40- by 80-foot wind tunnel for component acoustic testing for the second generation supersonic transport

NASA Technical Reports Server (NTRS)

Schmitz, F. H.; Allmen, J. R.; Soderman, P. T.

1994-01-01

The development of a large-scale anechoic test facility where large models of engine/airframe/high-lift systems can be tested for both improved noise reduction and minimum performance degradation is described. The facility development is part of the effort to investigate economically viable methods of reducing second generation high speed civil transport noise during takeoff and climb-out that is now under way in the United States. This new capability will be achieved through acoustic modifications of NASA's second largest subsonic wind tunnel: the 40-by 80-Foot Wind Tunnel at the NASA Ames Research Center. Three major items are addressed in the design of this large anechoic and quiet wind tunnel: a new deep (42 inch (107 cm)) test section liner, expansion of the wind tunnel drive operating envelope at low rpm to reduce background noise, and other promising methods of improving signal-to-noise levels of inflow microphones. Current testing plans supporting the U.S. high speed civil transport program are also outlined.

Structural modification of polysaccharides: A biochemical-genetic approach

NASA Technical Reports Server (NTRS)

Kern, Roger G.; Petersen, Gene R.

1991-01-01

Polysaccharides have a wide range of industrial and biomedical applications. An industry trend is underway towards the increased use of bacteria to produce polysaccharides. Long term goals of this work are the adaptation and enhancement of saccharide properties for electronic and optic applications. In this report we illustrate the application of enzyme-bearing bacteriophage on strains of the enteric bacterium Klebsiella pneumoniae, which produces a polysaccharide with the relatively rare rheological property of drag-reduction. This has resulted in the production of new polysaccharides with enhanced rheological properties. Our laboratory is developing techniques for processing and structurally modifying bacterial polysaccharides and oligosaccharides which comprise their basic polymeric repeat units. Our research has focused on bacteriophage which produce specific polysaccharide degrading enzymes. This has lead to the development of enzymes generated by bacteriophage as tools for polysaccharide modification and purification. These enzymes were used to efficiently convert the native material to uniform-sized high molecular weight polymers, or alternatively into high-purity oligosaccharides. Enzyme-bearing bacteriophage also serve as genetic selection tools for bacteria that produce new families of polysaccharides with modified structures.

Addendum to the Closure Report for Corrective Action Unit 404: Roller Coaster Sewage Lagoons and North Disposal Trench, Tonopah Test Range, Nevada, Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the September 1998, Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, thismore » addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the modification of the UR for CAS TA-03-001-TARC Roller Coaster Lagoons. This UR was established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and was based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since this UR was established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, this UR was re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This reevaluation consisted of comparing the original data (used to define the need for the UR) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to modify the UR for CAS TA-03-001-TARC to an administrative UR. Administrative URs differ from standard URs in that they do not require onsite postings (i.e., signs) or other physical barriers (e.g., fencing, monuments), and they do not require periodic inspections (see Section 6.2 of the Industrial Sites Project Establishment of Final Action Levels [NNSA/NSO, 2006c]). This Administrative UR was based on a “Remote Work Sites” future land use scenario that was used to calculate the FAL. The administrative UR will protect workers from an exposure exceeding that used in the calculation of the FAL (i.e., 336 hours per year). Any proposed activity within these use restricted areas that would potentially cause an exposure exceeding this exposure limit would require approval from the Nevada Division of Environmental Protection (NDEP). Requirements for inspecting and maintaining this UR will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

PubMed Central

Gaiti, Federico; Jindrich, Katia; Fernandez-Valverde, Selene L; Roper, Kathrein E; Degnan, Bernard M; Tanurdžić, Miloš

2017-01-01

Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity. DOI: http://dx.doi.org/10.7554/eLife.22194.001 PMID:28395144

Testing and analysis of the impact on engine cycle parameters and control system modifications using hydrogen or methane as fuel in an industrial gas turbine

NASA Astrophysics Data System (ADS)

Funke, H. H.-W.; Keinz, J.; Börner, S.; Hendrick, P.; Elsing, R.

2016-07-01

The paper highlights the modification of the engine control software of the hydrogen (H2) converted gas turbine Auxiliary Power Unit (APU) GTCP 36-300 allowing safe and accurate methane (CH4) operation achieved without mechanical changes of the metering unit. The acceleration and deceleration characteristics of the engine controller from idle to maximum load are analyzed comparing H2 and CH4. Also, the paper presents the influence on the thermodynamic cycle of gas turbine resulting from the different fuels supported by a gas turbine cycle simulation of H2 and CH4 using the software GasTurb.

77 FR 23113 - Modification of VOR Federal Airways V-135 and V-137; Southwest United States

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

...-0654; Airspace Docket No. 11-AWP-8] RIN 2120-AA66 Modification of VOR Federal Airways V-135 and V-137...: This action modifies VHF omnidirectional range (VOR) Federal airways V-135 and V-137 by extending the... published in the Federal Register a notice of proposed rulemaking (NPRM) to modify V-135 and V-137 in the...

Methodological guidelines for developing accident modification functions.

PubMed

Elvik, Rune

2015-07-01

This paper proposes methodological guidelines for developing accident modification functions. An accident modification function is a mathematical function describing systematic variation in the effects of road safety measures. The paper describes ten guidelines. An example is given of how to use the guidelines. The importance of exploratory analysis and an iterative approach in developing accident modification functions is stressed. The example shows that strict compliance with all the guidelines may be difficult, but represents a level of stringency that should be strived for. Currently the main limitations in developing accident modification functions are the small number of good evaluation studies and the often huge variation in estimates of effect. It is therefore still not possible to develop accident modification functions for very many road safety measures. Copyright © 2015 Elsevier Ltd. All rights reserved.

77 FR 15803 - Notice of Lodging of Stipulated Order Regarding Modification of Consent Decree in United States v...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... Decree in United States v. Kentucky Utilities Company Under the Clean Air Act Under 28 CFR 50.7, notice... Decree (``Stipulated Order'') between Kentucky Utilities Company (``Kentucky Utilities'') and the United... provisions of the Clean Air Act, 42 U.S.C. 7401, et seq., in connection with its operation of the E.W. Brown...

40 CFR 75.19 - Optional SO2, NOX, and CO2 emissions calculation for low mass emissions (LME) units.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), manufacturer and model, and must have the same history of modifications (e.g., have the same controls installed... (or group of identical units) equipped with SCR (or SNCR) and uses dry low-NOX technology to control... with add-on NOX emission controls, and for units that use dry low-NOX technology, the owner or operator...

76 FR 30902 - Shasta Lake Management Unit, Shasta-Trinity National Forest; California; Green-Horse Habitat...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... management strategy to allow modification of treatments if necessary during implementation. A project-level... to 15 tons per acre for those two management prescriptions. This project-level amendment is proposed... Management Unit, Shasta-Trinity National Forest; California; Green-Horse Habitat Restoration and Maintenance...

Preservation Building Survey Form for Freestanding Library Unit.

ERIC Educational Resources Information Center

Huff, Susan M.

A modification of a University of Michigan form, this survey form is designed to obtain information on a freestanding library unit for preservation. The questionnaire covers the following areas: (1) library facility construction--e.g., primary building materials, characteristics of the foundation and roof, recent problems; (2) heating and cooling…

The UN's water torture.

PubMed

Miller, Henry I

2010-01-01

The United Nations is a bastion of corruption, profligacy and incompetence that is a particular threat to the inhabitants of poor nations. Its policies, programs and agencies have made a growth industry of the unscientific regulation of important technologies-of which gene-splicing [also known as recombinant DNA technology or genetic modification (GM)] is only one. The UN's actions regularly defy scientific consensus and common sense, instead pandering to extremists. The result is vastly inflated research and development costs, less innovation, and diminished exploitation of superior techniques and products that could offer monumental humanitarian and economic benefits.

Acclimation of isoprene emission and photosynthesis to growth temperature in hybrid aspen: resolving structural and physiological controls

PubMed Central

Rasulov, Bahtijor; Bichele, Irina; Hüve, Katja; Vislap, Vivian; Niinemets, Ülo

2018-01-01

Acclimation of foliage to growth temperature involves both structural and physiological modifications, but the relative importance of these two mechanisms of acclimation is poorly known, especially for isoprene emission responses. We grew hybrid aspen (Populus tremula x P. tremuloides) under control (day/night temperature of 25/20 °C) and high temperature conditions (35/27 °C) to gain insight into the structural and physiological acclimation controls. Growth at high temperature resulted in larger and thinner leaves with smaller and more densely packed chloroplasts and with lower leaf dry mass per area (MA). High growth temperature also led to lower photosynthetic and respiration rates, isoprene emission rate and leaf pigment content and isoprene substrate dimethylallyl diphosphate pool size per unit area, but to greater stomatal conductance. However, the declining characteristics were similar when expressed per unit dry mass, indicating that the area-based differences were primarily driven by MA. Acclimation to high temperature further increased heat stability of photosynthesis, and increased activation energies for isoprene emission and isoprene synthase rate constant. This study demonstrates that temperature acclimation of photosynthetic and isoprene emission characteristics per unit leaf area was primarily driven by structural modifications, and we argue that future studies investigating acclimation to growth temperature must consider structural modifications. PMID:25158785

Assessing managerial information needs: Modification and evaluation of the Hospital Shift Leaders' Information Needs Questionnaire.

PubMed

Peltonen, Laura-Maria; Lundgrén-Laine, Heljä; Siirala, Eriikka; Löyttyniemi, Eliisa; Aantaa, Riku; Salanterä, Sanna

2018-03-01

The aims were (1) to evaluate the modified version of the Intensive Care Unit Information Need Questionnaire for the broader hospital setting, and (2) to describe the differences in respondents' managerial activities and information needs according to the position held by the respondent and the type of hospital unit. Information systems do not support managerial decision-making sufficiently and information needed in the day-to-day operations management in hospital units is unknown. An existing questionnaire was modified and evaluated. Shift leaders, that is, the nurses and physicians responsible for the day-to-day operations management in hospital units were reached using purposive sampling (n = 258). The questionnaire ascertained the importance of information. Cronbach's α ranged from .85-.96 for the subscales. Item - total correlations showed good explanatory power. Managerial activities and information needs differed between respondents in different positions, although all shared about one-third of important information needs. The response rate was 26% (n = 67). The validity and reliability of the questionnaire were good. Attention should be paid to the positions of shift leaders when developing information systems. The questionnaire can be used to determine important information when developing information systems to support day-to-day operations management in hospitals. © 2018 John Wiley & Sons Ltd.

Antibacterial modification of an injectable, biodegradable, non-cytotoxic block copolymer-based physical gel with body temperature-stimulated sol-gel transition and controlled drug release.

PubMed

Wang, Xiaowen; Hu, Huawen; Wang, Wenyi; Lee, Ka I; Gao, Chang; He, Liang; Wang, Yuanfeng; Lai, Chuilin; Fei, Bin; Xin, John H

2016-07-01

Biomaterials are being extensively used in various biomedical fields; however, they are readily infected with microorganisms, thus posing a serious threat to the public health care. We herein presented a facile route to the antibacterial modification of an important A-B-A type biomaterial using poly (ethylene glycol) methyl ether (mPEG)- poly(ε-caprolactone) (PCL)-mPEG as a typical model. Inexpensive, commercial bis(2-hydroxyethyl) methylammonium chloride (DMA) was adopted as an antibacterial unit. The effective synthesis of the antibacterial copolymer mPEG-PCL-∼∼∼-PCL-mPEG (where ∼∼∼ denotes the segment with DMA units) was well confirmed by FTIR and (1)H NMR spectra. At an appropriate modification extent, the DMA unit could render the copolymer mPEG-PCL-∼∼∼-PCL-mPEG highly antibacterial, but did not largely alter its fascinating intrinsic properties including the thermosensitivity (e.g., the body temperature-induced sol-gel transition), non-cytotoxicity, and controlled drug release. A detailed study on the sol-gel-sol transition behavior of different copolymers showed that an appropriate extent of modification with DMA retained a sol-gel-sol transition, despite the fact that a too high extent caused a loss of sol-gel-sol transition. The hydrophilic and hydrophobic balance between mPEG and PCL was most likely broken upon a high extent of quaternization due to a large disturbance effect of DMA units at a large quantity (as evidenced by the heavily depressed PCL segment crystallinity), and thus the micelle aggregation mechanism for the gel formation could not work anymore, along with the loss of the thermosensitivity. The work presented here is highly expected to be generalized for synthesis of various block copolymers with immunity to microorganisms. Light may also be shed on understanding the phase transition behavior of various multiblock copolymers. Copyright © 2016 Elsevier B.V. All rights reserved.

Grass flower development.

PubMed

Hirano, Hiro-Yuki; Tanaka, Wakana; Toriba, Taiyo

2014-01-01

Grasses bear unique flowers lacking obvious petals and sepals in special inflorescence units, the florets and the spikelet. Despite this, grass floral organs such as stamens and lodicules (petal homologs) are specified by ABC homeotic genes encoding MADS domain transcription factors, suggesting that the ABC model of eudicot flower development is largely applicable to grass flowers. However, some modifications need to be made for the model to fit grasses well: for example, a YABBY gene plays an important role in carpel specification. In addition, a number of genes are involved in the development of the lateral organs that constitute the spikelet. In this review, we discuss recent progress in elucidating the genes required for flower and spikelet development in grasses, together with those involved in fate determination of the spikelet and flower meristems.

77 FR 66869 - Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... entitled United States, et al. v. Marathon Ashland Petroleum LLC, Civil Action No. 01-40119 (PVG). Under the original 2001 consent decree, Marathon Ashland Petroleum LLC (``Marathon'') agreed to implement... particulate matter from refinery process units at seven refineries then owned and operated by Marathon...

Methods and strategies for future reactor safety goals

NASA Astrophysics Data System (ADS)

Arndt, Steven Andrew

There have been significant discussions over the past few years by the United States Nuclear Regulatory Commission (NRC), the Advisory Committee on Reactor Safeguards (ACRS), and others as to the adequacy of the NRC safety goals for use with the next generation of nuclear power reactors to be built in the United States. The NRC, in its safety goals policy statement, has provided general qualitative safety goals and basic quantitative health objectives (QHOs) for nuclear reactors in the United States. Risk metrics such as core damage frequency (CDF) and large early release frequency (LERF) have been used as surrogates for the QHOs. In its review of the new plant licensing policy the ACRS has looked at the safety goals, as has the NRC. A number of issues have been raised including what the Commission had in mind when it drafted the safety goals and QHOs, how risk from multiple reactors at a site should be combined for evaluation, how the combination of a new and old reactor at the same site should be evaluated, what the criteria for evaluating new reactors should be, and whether new reactors should be required to be safer than current generation reactors. As part of the development and application of the NRC safety goal policy statement the Commissioners laid out the expectations for the safety of a nuclear power plant but did not address the risk associated with current multi-unit sites, potential modular reactor sites, and hybrid sites that could contain current generation reactors, new passive reactors, and/or modular reactors. The NRC safety goals and the QHOs refer to a "nuclear power plant," but do not discuss whether a "plant" refers to only a single unit or all of the units on a site. There has been much discussion on this issue recently due to the development of modular reactors. Additionally, the risk of multiple reactor accidents on the same site has been largely ignored in the probabilistic risk assessments (PRAs) done to date, and in most risk-informed analyses and discussions. This dissertation examines potential approaches to updating the safety goals that include the establishment of new quantitative safety goal associated with the comparative risk of generating electricity by viable competing technologies and modifications of the goals to account for multi-plant reactor sites, and issues associated with the use of safety goals in both initial licensing and operational decision making. This research develops a new quantitative health objective that uses a comparable benefit risk metric based on the life-cycle risk of the construction, operation and decommissioning of a comparable non-nuclear electric generation facility, as well as the risks associated with mining and transportation. This dissertation also evaluates the effects of using various methods for aggregating site risk as a safety metric, as opposed to using single plant safety goals. Additionally, a number of important assumptions inherent in the current safety goals, including the effect of other potential negative societal effects such as the generation of greenhouse gases (e.g., carbon dioxide) have on the risk of electric power production and their effects on the setting of safety goals, is explored. Finally, the role risk perception should play in establishing safety goals has been explored. To complete this evaluation, a new method to analytically compare alternative technologies of generating electricity was developed, including development of a new way to evaluate risk perception, and a new method was developed for evaluating the risk at multiple units on a single site. To test these modifications to the safety goals a number of possible reactor designs and configurations were evaluated using these new proposed safety goals to determine the goals' usefulness and utility. The results of the analysis showed that the modifications provide measures that more closely evaluate the potential risk to the public from the operation of nuclear power plants than the current safety goals, while still providing a straight-forward process for assessment of reactor design and operation.

A historical review of additives and modifiers used in paving asphalt refining processes in the United States.

PubMed

Mundt, Diane J; Adams, Robert C; Marano, Kristin M

2009-11-01

The U.S. asphalt paving industry has evolved over time to meet various performance specifications for liquid petroleum asphalt binder (known as bitumen outside the United States). Additives to liquid petroleum asphalt produced in the refinery may affect exposures to workers in the hot mix paving industry. This investigation documented the changes in the composition and distribution of the liquid petroleum asphalt products produced from petroleum refining in the United States since World War II. This assessment was accomplished by reviewing documents and interviewing individual experts in the industry to identify current and historical practices. Individuals from 18 facilities were surveyed; the number of facilities reporting use of any material within a particular class ranged from none to more than half the respondents. Materials such as products of the process stream, polymers, elastomers, and anti-strip compounds have been added to liquid petroleum asphalt in the United States over the past 50 years, but modification has not been generally consistent by geography or time. Modifications made to liquid petroleum asphalt were made generally to improve performance and were dictated by state specifications.

Addendum to the Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn Kidman

This document constitutes an addendum to the September 1998, Closure Report for Corrective Action Unit 404: Roller Coaster Lagoons and Trench, Tonopah Test Range, Nevada as described in the document Recommendations and Justifications for Modifications for Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office Federal Facility Agreement and Consent Order (UR Modification document) dated February 2008. The UR Modification document was approved by NDEP on February 26, 2008. The approval of the UR Modification document constituted approval of each of the recommended UR modifications. In conformance with the UR Modification document, thismore » addendum consists of: • This cover page that refers the reader to the UR Modification document for additional information • The cover and signature pages of the UR Modification document • The NDEP approval letter • The corresponding section of the UR Modification document This addendum provides the documentation justifying the cancellation of the URs for: • CAS TA-03-001-TARC Roller Coaster Lagoons • CAS TA-21-001-TARC Roller Coaster N. Disposal Trench These URs were established as part of Federal Facility Agreement and Consent Order (FFACO) corrective actions and were based on the presence of contaminants at concentrations greater than the action levels established at the time of the initial investigation (FFACO, 1996; as amended August 2006). Since these URs were established, practices and procedures relating to the implementation of risk-based corrective actions (RBCA) have changed. Therefore, these URs were re-evaluated against the current RBCA criteria as defined in the Industrial Sites Project Establishment of Final Action Levels (NNSA/NSO, 2006c). This re-evaluation consisted of comparing the original data (used to define the need for the URs) to risk-based final action levels (FALs) developed using the current Industrial Sites RBCA process. The re-evaluation resulted in a recommendation to modify these URs to administrative URs. Administrative URs differ from standard URs in that they do not require onsite postings (i.e., signs) or other physical barriers (e.g., fencing, monuments), and they do not require periodic inspections (see Section 6.2 of the Industrial Sites Project Establishment of Final Action Levels [NNSA/NSO, 2006c]). These Administrative URs were based on a “Remote Work Sites” future land use scenario that was used to calculate the FAL. The administrative UR will protect workers from an exposure exceeding that used in the calculation of the FAL (i.e., 336 hours per year). Any proposed activity within these use restricted areas that would potentially cause an exposure exceeding this exposure limit would require approval from the Nevada Division of Environmental Protection (NDEP). Requirements for inspecting and maintaining these URs will be canceled, and the postings and signage at each site will be removed. Fencing and posting may be present at these sites that are unrelated to the FFACO URs such as for radiological control purposes as required by the NV/YMP Radiological Control Manual (NNSA/NSO, 2004f). This modification will not affect or modify any non-FFACO requirements for fencing, posting, or monitoring at these sites.« less

Estimating aquatic toxicity as determined through laboratory tests of great lakes sediments containing complex mixtures of environmental contaminants

USGS Publications Warehouse

1996-01-01

We developed and evaluated a total toxic units modeling approach for predicting mean toxicity as measured in laboratory tests for Great Lakes sediments containing complex mixtures of environmental contaminants (e.g., polychlorinated biphenyls, polycyclic aromatic hydrocarbons, pesticides, chlorinated dioxins, and metals). The approach incorporates equilibrium partitioning and organic carbon control of bioavailability for organic contaminants and acid volatile sulfide (AVS) control for metals, and includes toxic equivalency for planar organic chemicals. A toxic unit is defined as the ratio of the estimated pore-water concentration of a contaminant to the chronic toxicity of that contaminant, as estimated by U.S. Environmental Protection Agency Ambient Water Quality Criteria (AWQC). The toxic unit models we developed assume complete additivity of contaminant effects, are completely mechanistic in form, and were evaluated without any a posteriori modification of either the models or the data from which the models were developed and against which they were tested. A linear relationship between total toxic units, which included toxicity attributable to both iron and un-ionized ammonia, accounted for about 88% of observed variability in mean toxicity; a quadratic relationship accounted for almost 94%. Exclusion of either bioavailability components (i.e., equilibrium partitioning control of organic contaminants and AVS control of metals) or iron from the model substantially decreased its ability to predict mean toxicity. A model based solely on un-ionized ammonia accounted for about 47% of the variability in mean toxicity. We found the toxic unit approach to be a viable method for assessing and ranking the relative potential toxicity of contaminated sediments.

Application of laws, policies, and guidance from the United States and Canada to the regulation of food and feed derived from genetically modified crops: interpretation of composition data.

PubMed

Price, William D; Underhill, Lynne

2013-09-04

With the development of recombinant DNA techniques for genetically modifying plants to exhibit beneficial traits, laws and regulations were adopted to ensure the safety of food and feed derived from such plants. This paper focuses on the regulation of genetically modified (GM) plants in Canada and the United States, with emphasis on the results of the compositional analysis routinely utilized as an indicator of possible unintended effects resulting from genetic modification. This work discusses the mandate of Health Canada and the Canadian Food Inspection Agency as well as the U.S. Food and Drug Administration's approach to regulating food and feed derived from GM plants. This work also addresses how publications by the Organisation for Economic Co-operation and Development and Codex Alimentarius fit, particularly with defining the importance and purpose of compositional analysis. The importance of study design, selection of comparators, use of literature, and commercial variety reference values is also discussed.

Wildlife conservation and solar energy development in the Desert Southwest, United States

USGS Publications Warehouse

Lovich, Jeffrey E.; Ennen, Josua R.

2011-01-01

Large areas of public land are currently being permitted or evaluated for utility-scale solar energy development (USSED) in the southwestern United States, including areas with high biodiversity and protected species. However, peer-reviewed studies of the effects of USSED on wildlife are lacking. The potential effects of the construction and the eventual decommissioning of solar energy facilities include the direct mortality of wildlife; environmental impacts of fugitive dust and dust suppressants; destruction and modification of habitat, including the impacts of roads; and off-site impacts related to construction material acquisition, processing, and transportation. The potential effects of the operation and maintenance of the facilities include habitat fragmentation and barriers to gene flow, increased noise, electromagnetic field generation, microclimate alteration, pollution, water consumption, and fire. Facility design effects, the efficacy of site-selection criteria, and the cumulative effects of USSED on regional wildlife populations are unknown. Currently available peer-reviewed data are insufficient to allow a rigorous assessment of the impact of USSED on wildlife.

Capacitor blocks for linear transformer driver stages.

PubMed

Kovalchuk, B M; Kharlov, A V; Kumpyak, E V; Smorudov, G V; Zherlitsyn, A A

2014-01-01

In the Linear Transformer Driver (LTD) technology, the low inductance energy storage components and switches are directly incorporated into the individual cavities (named stages) to generate a fast output voltage pulse, which is added along a vacuum coaxial line like in an inductive voltage adder. LTD stages with air insulation were recently developed, where air is used both as insulation in a primary side of the stages and as working gas in the LTD spark gap switches. A custom designed unit, referred to as a capacitor block, was developed for use as a main structural element of the transformer stages. The capacitor block incorporates two capacitors GA 35426 (40 nF, 100 kV) and multichannel multigap gas switch. Several modifications of the capacitor blocks were developed and tested on the life time and self breakdown probability. Blocks were tested both as separate units and in an assembly of capacitive module, consisting of five capacitor blocks. This paper presents detailed design of capacitor blocks, description of operation regimes, numerical simulation of electric field in the switches, and test results.

A clinical audit of postoperative urinary retention in the postanesthesia care unit.

PubMed

McLeod, Laura; Southerland, Kerry; Bond, Jade

2013-08-01

Postoperative urinary retention (PUR) is a common postsurgical complication. Early detection and management of PUR is of particular concern to nurses working in the postanesthesia care unit (PACU) because a single episode of bladder distention may result in permanent bladder damage. A clinical audit (CA) was conducted that examined the risk factors that may contribute to the development of PUR in the PACU. The CA was conducted over a 1-week time period and used a data collection tool that was developed from the current literature. A total of 34 patients met the inclusion criteria for the CA, and a prevalence rate of 20.6% was reported, which was consistent with prevalence rates reported by larger research studies. Despite the small sample size of this CA, results suggested that PUR should be of concern to nurses in the PACU. Recommendations included the development and implementation of a guideline relating to bladder scanning in the PACU and modification of existing PACU discharge criteria to include bladder management. Copyright © 2013 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

Complex Interplay among DNA Modification, Noncoding RNA Expression and Protein-Coding RNA Expression in Salvia miltiorrhiza Chloroplast Genome

PubMed Central

Chen, Haimei; Zhang, Jianhui; Yuan, George; Liu, Chang

2014-01-01

Salvia miltiorrhiza is one of the most widely used medicinal plants. As a first step to develop a chloroplast-based genetic engineering method for the over-production of active components from S. miltiorrhiza, we have analyzed the genome, transcriptome, and base modifications of the S. miltiorrhiza chloroplast. Total genomic DNA and RNA were extracted from fresh leaves and then subjected to strand-specific RNA-Seq and Single-Molecule Real-Time (SMRT) sequencing analyses. Mapping the RNA-Seq reads to the genome assembly allowed us to determine the relative expression levels of 80 protein-coding genes. In addition, we identified 19 polycistronic transcription units and 136 putative antisense and intergenic noncoding RNA (ncRNA) genes. Comparison of the abundance of protein-coding transcripts (cRNA) with and without overlapping antisense ncRNAs (asRNA) suggest that the presence of asRNA is associated with increased cRNA abundance (p<0.05). Using the SMRT Portal software (v1.3.2), 2687 potential DNA modification sites and two potential DNA modification motifs were predicted. The two motifs include a TATA box–like motif (CPGDMM1, “TATANNNATNA”), and an unknown motif (CPGDMM2 “WNYANTGAW”). Specifically, 35 of the 97 CPGDMM1 motifs (36.1%) and 91 of the 369 CPGDMM2 motifs (24.7%) were found to be significantly modified (p<0.01). Analysis of genes downstream of the CPGDMM1 motif revealed the significantly increased abundance of ncRNA genes that are less than 400 bp away from the significantly modified CPGDMM1motif (p<0.01). Taking together, the present study revealed a complex interplay among DNA modifications, ncRNA and cRNA expression in chloroplast genome. PMID:24914614

Complex interplay among DNA modification, noncoding RNA expression and protein-coding RNA expression in Salvia miltiorrhiza chloroplast genome.

PubMed

Chen, Haimei; Zhang, Jianhui; Yuan, George; Liu, Chang

2014-01-01

Salvia miltiorrhiza is one of the most widely used medicinal plants. As a first step to develop a chloroplast-based genetic engineering method for the over-production of active components from S. miltiorrhiza, we have analyzed the genome, transcriptome, and base modifications of the S. miltiorrhiza chloroplast. Total genomic DNA and RNA were extracted from fresh leaves and then subjected to strand-specific RNA-Seq and Single-Molecule Real-Time (SMRT) sequencing analyses. Mapping the RNA-Seq reads to the genome assembly allowed us to determine the relative expression levels of 80 protein-coding genes. In addition, we identified 19 polycistronic transcription units and 136 putative antisense and intergenic noncoding RNA (ncRNA) genes. Comparison of the abundance of protein-coding transcripts (cRNA) with and without overlapping antisense ncRNAs (asRNA) suggest that the presence of asRNA is associated with increased cRNA abundance (p<0.05). Using the SMRT Portal software (v1.3.2), 2687 potential DNA modification sites and two potential DNA modification motifs were predicted. The two motifs include a TATA box-like motif (CPGDMM1, "TATANNNATNA"), and an unknown motif (CPGDMM2 "WNYANTGAW"). Specifically, 35 of the 97 CPGDMM1 motifs (36.1%) and 91 of the 369 CPGDMM2 motifs (24.7%) were found to be significantly modified (p<0.01). Analysis of genes downstream of the CPGDMM1 motif revealed the significantly increased abundance of ncRNA genes that are less than 400 bp away from the significantly modified CPGDMM1motif (p<0.01). Taking together, the present study revealed a complex interplay among DNA modifications, ncRNA and cRNA expression in chloroplast genome.

Development and industrial application of oil-reburning for NO{sub x} emission control in utility boilers

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Michele, G.; Pasini, S.; Tarli, R.

1996-01-01

ENEL is conducting a comprehensive modification program within its generating system, in order to comply with the new Italian air quality standards for fossil fuel-fired power plants, which set a limit for NO{sub x} of 200 mg/Nm{sup 3} corrected to 3% O{sub 2} for oil and gas and to 6% O{sub 2} for coal. Among all combustion modification technologies reburning has proven particularly attractive, since it has been demonstrated that it generally permits to satisfy the regulatory requirements in gas and oil fired units, thus avoiding the use of SCR. The ENEL generating system essentially employs tangentially fired (TF) andmore » front/opposed wall fired boilers belonging, respectively, to the CEI and Babcock & Wilcox (B&W) technology, designed and constructed by Ansaldo and Franco Tosi (now bought by Ansaldo). In this framework ENEL has signed respectively with Ansaldo Energia and Combustion Engineering Inc. (CEI), and with Ansaldo Energia two separate agreements to apply Reburn Technology in oil and gas, tangentially-fired (TF) utility boilers, the first, and oil and gas wall-fired (WF) utility boilers, the second, both in Italy and abroad. This paper outlines the technical knowledge available for the design of reburn systems for a retrofit application and describes the main results obtained, after retrofit, at Torvaldaliga No. 2 power station, 320 MW{sub e} (TF), firing both oil and gas as reburn fuels, and at Cassano unit No. 1, 75 MW{sub e} (WF), firing gas as main and reburn fuels. Reference is also made to the development of the projects for the application of the technology at Monfalcone, 320 MW{sub e} (WF), in the oil over oil configuration, whose demonstration is planned for the Autumn of 1995, and at Porto Tolle unit No. 1, 660 MW{sub e} (TF), that is planned to start in January 1996.« less

Analytical resource assessment method for continuous (unconventional) oil and gas accumulations - The "ACCESS" Method

USGS Publications Warehouse

Crovelli, Robert A.; revised by Charpentier, Ronald R.

2012-01-01

The U.S. Geological Survey (USGS) periodically assesses petroleum resources of areas within the United States and the world. The purpose of this report is to explain the development of an analytic probabilistic method and spreadsheet software system called Analytic Cell-Based Continuous Energy Spreadsheet System (ACCESS). The ACCESS method is based upon mathematical equations derived from probability theory. The ACCESS spreadsheet can be used to calculate estimates of the undeveloped oil, gas, and NGL (natural gas liquids) resources in a continuous-type assessment unit. An assessment unit is a mappable volume of rock in a total petroleum system. In this report, the geologic assessment model is defined first, the analytic probabilistic method is described second, and the spreadsheet ACCESS is described third. In this revised version of Open-File Report 00-044 , the text has been updated to reflect modifications that were made to the ACCESS program. Two versions of the program are added as appendixes.

Modification of the supramolecular structure of collagen with nanodisperse hydroxyapatite

NASA Astrophysics Data System (ADS)

Voloskova, E. V.; Berdnikova, L. K.; Poluboyarov, V. A.; Gur'yanova, T. I.

2015-02-01

The influence of nanodisperse particles of hydroxyapatite on the structure of films based on collagen with a molecular mass of 360 kDa was studied. When coatings formed, the collagen macromolecules aggregated into spherulites; modification led to structural changes related to the decomposition of the spherulite structure and the formation of a grain structure. The variation of the physicomechanical properties of film materials directly depends on the size of the structural units.

Shallow Water Marine UXO Detection Survey, United States Marine Corps Base, Camp Lejeune, North Carolina

DTIC Science & Technology

2011-04-01

resolution time-domain EM metal detector that is capable of detecting both ferrous and nonferrous metallic objects. The EM61 consists of air-cored...modifications to the Geonics EM61 metal detector . Modifications include higher transmitter power and frequency, faster sampling rates, and flexible...towed array (UUTA) electromagnetic system designed by 3Dgeophysics.com (3Dg) utilizes modified and improved Geonics, Ltd. electromagnetic (EM)61 metal

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

43 CFR 3931.50 - Exploration plan and plan of development modifications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Exploration plan and plan of development... EXPLORATION AND LEASES Plans of Development and Exploration Plans § 3931.50 Exploration plan and plan of development modifications. (a) The operator or lessee may apply in writing to the BLM for modification of the...

Frictional Performance Assessment of Cemented Carbide Surfaces Textured by Laser

NASA Astrophysics Data System (ADS)

Fang, S.; Llanes, L.; Klein, S.; Gachot, C.; Rosenkranz, A.; Bähre, D.; Mücklich, F.

2017-10-01

Cemented carbides are advanced engineering materials often used in industry for manufacturing cutting tools or supporting parts in tribological system. In order to improve service life, special attention has been paid to change surface conditions by means of different methods, since surface modification can be beneficial to reduce the friction between the contact surfaces as well as to avoid unintended damage. Laser surface texturing is one of the newly developed surface modification methods. It has been successfully introduced to fabricate some basic patterns on cemented carbide surfaces. In this work, Direct Laser Interference Patterning Technique (DLIP) is implemented to produce special line-like patterns on a cobalt (Co) and nickel (Ni) based cemented tungsten carbide grade. It is proven that the laser-produced patterns have high geometrical precision and quality stability. Furthermore, tribology testing using a nano-tribometer unit shows that friction is reduced by the line-like patterns, as compared to the polished one, under both lubricated and dry testing regimes, and the reduction is more pronounced in the latter case.

Ground motion models used in the 2014 U.S. National Seismic Hazard Maps

USGS Publications Warehouse

Rezaeian, Sanaz; Petersen, Mark D.; Moschetti, Morgan P.

2015-01-01

The National Seismic Hazard Maps (NSHMs) are an important component of seismic design regulations in the United States. This paper compares hazard using the new suite of ground motion models (GMMs) relative to hazard using the suite of GMMs applied in the previous version of the maps. The new source characterization models are used for both cases. A previous paper (Rezaeian et al. 2014) discussed the five NGA-West2 GMMs used for shallow crustal earthquakes in the Western United States (WUS), which are also summarized here. Our focus in this paper is on GMMs for earthquakes in stable continental regions in the Central and Eastern United States (CEUS), as well as subduction interface and deep intraslab earthquakes. We consider building code hazard levels for peak ground acceleration (PGA), 0.2-s, and 1.0-s spectral accelerations (SAs) on uniform firm-rock site conditions. The GMM modifications in the updated version of the maps created changes in hazard within 5% to 20% in WUS; decreases within 5% to 20% in CEUS; changes within 5% to 15% for subduction interface earthquakes; and changes involving decreases of up to 50% and increases of up to 30% for deep intraslab earthquakes for most U.S. sites. These modifications were combined with changes resulting from modifications in the source characterization models to obtain the new hazard maps.

Acclimation of isoprene emission and photosynthesis to growth temperature in hybrid aspen: resolving structural and physiological controls.

PubMed

Rasulov, Bahtijor; Bichele, Irina; Hüve, Katja; Vislap, Vivian; Niinemets, Ülo

2015-04-01

Acclimation of foliage to growth temperature involves both structural and physiological modifications, but the relative importance of these two mechanisms of acclimation is poorly known, especially for isoprene emission responses. We grew hybrid aspen (Populus tremula x P. tremuloides) under control (day/night temperature of 25/20 °C) and high temperature conditions (35/27 °C) to gain insight into the structural and physiological acclimation controls. Growth at high temperature resulted in larger and thinner leaves with smaller and more densely packed chloroplasts and with lower leaf dry mass per area (MA). High growth temperature also led to lower photosynthetic and respiration rates, isoprene emission rate and leaf pigment content and isoprene substrate dimethylallyl diphosphate pool size per unit area, but to greater stomatal conductance. However, all physiological characteristics were similar when expressed per unit dry mass, indicating that the area-based differences were primarily driven by MA. Acclimation to high temperature further increased heat stability of photosynthesis and increased activation energies for isoprene emission and isoprene synthase rate constant. This study demonstrates that temperature acclimation of photosynthetic and isoprene emission characteristics per unit leaf area were primarily driven by structural modifications, and we argue that future studies investigating acclimation to growth temperature must consider structural modifications. © 2014 John Wiley & Sons Ltd.

TEACHERS' GUIDE. NINTH GRADE PLANE AND SOLID GEOMETRY FOR THE ACADEMICALLY TALENTED.

ERIC Educational Resources Information Center

HORN, R.A.

MATERIALS ARE INTENDED FOR A UNIFIED AND ACCELERATED PLANE AND SOLID GEOMETRY COURSE AND FOR EASY MODIFICATION AND ADAPTATION BY EXPERIENCED OR INEXPERIENCED TEACHER. TEXTBOOKS TO WHICH THE GUIDE HAS BEEN KEYED ARE LISTED. UNITS ARE GIVEN FOR BOTH SEMESTERS WITH TIME ALLOTMENTS RECOMMENDED. EACH UNIT IS SUBDIVIDED INTO TOPICS AND OBJECTIVES,…

78 FR 63506 - Exelon Generation Company, LLC; Peach Bottom Atomic Power Station, Units 2 and 3; Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-24

... Environs PBAPS consists of Units 1, 2, and 3 located on approximately 620 acres of land in Peach Bottom... proposed EPU are summarized below. Non-Radiological Impacts Land Use and Aesthetic Impacts Potential land... plant modifications. Therefore, land use conditions and visual aesthetics would not change significantly...

Therapeutic communities, old and new.

PubMed

Jones, M

1979-01-01

The author attempts to clarify two largely different uses of term, Therapeutic Community (TC). By "old" TC he describes a movement which originated in psychiatry in the United Kingdom at the end of World War II. This was an attempt to establish a democratic system in hospitals where the domination of the doctors was replaced by open communication of content and feeling, information sharing, shared decision making, and problem solving shared as far as possible with all patients and staff. Daily meetings of all patients and staff formed the nucleus of this process. In recent years developments in the areas of systems theory, learning theory, and organization development have contributed to a better understanding of social organization and change. The "new" TCs derive from the more recent developments in the treatment of substance abuse. Central to this movement is Synanon and its many modification which use the clients' peer group to solve their own problems, largely eliminating mental health professionals. Linked with these "new" TCs is the development of Asklepieion units in prisons, which use Synanon "games" along with transactional analysis. An attempt is made to distinguish the methodologies used in TCs, "old" and "new".

Microcontroller based resonance tracking unit for time resolved continuous wave cavity-ringdown spectroscopy measurements.

PubMed

Votava, Ondrej; Mašát, Milan; Parker, Alexander E; Jain, Chaithania; Fittschen, Christa

2012-04-01

We present in this work a new tracking servoloop electronics for continuous wave cavity-ringdown absorption spectroscopy (cw-CRDS) and its application to time resolved cw-CRDS measurements by coupling the system with a pulsed laser photolysis set-up. The tracking unit significantly increases the repetition rate of the CRDS events and thus improves effective time resolution (and/or the signal-to-noise ratio) in kinetics studies with cw-CRDS in given data acquisition time. The tracking servoloop uses novel strategy to track the cavity resonances that result in a fast relocking (few ms) after the loss of tracking due to an external disturbance. The microcontroller based design is highly flexible and thus advanced tracking strategies are easy to implement by the firmware modification without the need to modify the hardware. We believe that the performance of many existing cw-CRDS experiments, not only time-resolved, can be improved with such tracking unit without any additional modification to the experiment. © 2012 American Institute of Physics

Advanced Understanding of Convection Initiation and Optimizing Cloud Seeding by Advanced Remote Sensing and Land Cover Modification over the United Arab Emirates

NASA Astrophysics Data System (ADS)

Wulfmeyer, V.; Behrendt, A.; Branch, O.; Schwitalla, T.

2016-12-01

A prerequisite for significant precipitation amounts is the presence of convergence zones. These are due to land surface heterogeneity, orography as well as mesoscale and synoptic scale circulations. Only, if these convergence zones are strong enough and interact with an upper level instability, deep convection can be initiated. For the understanding of convection initiation (CI) and optimal cloud seeding deployment, it is essential that these convergence zones are detected before clouds are developing in order to preempt the decisive microphysical processes for liquid water and ice formation. In this presentation, a new project on Optimizing Cloud Seeding by Advanced Remote Sensing and Land Cover Modification (OCAL) is introduced, which is funded by the United Arab Emirates Rain Enhancement Program (UAEREP). This project has two research components. The first component focuses on an improved detection and forecasting of convergence zones and CI by a) operation of scanning Doppler lidar and cloud radar systems during two seasonal field campaigns in orographic terrain and over the desert in the UAE, and b) advanced forecasting of convergence zones and CI with the WRF-NOAHMP model system. Nowcasting to short-range forecasting of convection will be improved by the assimilation of Doppler lidar and the UAE radar network data. For the latter, we will apply a new model forward operator developed at our institute. Forecast uncertainties will be assessed by ensemble simulations driven by ECMWF boundaries. The second research component of OCAL will study whether artificial modifications of land surface heterogeneity are possible through plantations or changes of terrain, leading to an amplification of convergence zones. This is based on our pioneering work on high-resolution modeling of the impact of plantations on weather and climate in arid regions. A specific design of the shape and location of plantations can lead to the formation of convergence zones, which can strengthen convergent flows already existing in the region of interest, thus amplifying convection and precipitation. We expect that this method can be successfully applied in regions with pre-existing land-surface heterogeneity and orography such as coastal areas with land-sea breezes and the Al Hajar Mountain range.

The m/r SEBT: development of a functional screening tool for dance educators.

PubMed

Wilson, Margaret; Batson, Glenna

2014-12-01

Dance screenings provide direct and indirect data bearing on a dancer's readiness to undertake rigorous physical training. Rarely, however, are dance teachers able to translate results from these screenings into practical technical knowledge. In this article, an example of a preseason assessment tool is presented that translates scientific findings into useful information for dance teachers conducting auditions. Designed as a baseline assessment of the dancer during auditioning, the m/r SEBT tool helps teachers stratify technical levels, identify injury risk, and consequently assist with immediate and appropriate recommendations for supplemental training and//or follow-up with a medical professional. The tool evolved out of more than 3 years of collaborative, multisite research utilizing the Star Excursion Balance Test (SEBT) as a dynamic test of balance. Modifications were made to render the test more dance-specific and to increase balance challenges. Within the 3-year period, more than 100 dancers were tested in four sites, two in the United States and two in the United Kingdom. Despite the relatively large collective sample size, neither the original SEBT nor its modifications (m/r SEBT) held robust face or content validity as balance screens. What did emerge, however, were qualitative criteria that the authors organized into a feasible assessment tool for preseason auditions. While this tool awaits further validation, its current evolution helps serve as a bridge between dance teachers' clinical and practical knowledge.

Inventory of native vegetation and related resources from space photography

NASA Technical Reports Server (NTRS)

Poulton, C. E.; Johnson, J. R.; Mouat, D. A.

1970-01-01

The application of space and high flight photography to vegetational resources in Arizona is discussed. Ecologically based vegetation-landform and land use maps are prepared. The use of material from the Apollo 9 flight and high flight aerial photography are discussed. Land uses that result in a conversion or strong modification of the natural vegetation are presented. The vegetation-landform units have an ecological basis and are meaningful from a land use point of view because they identify areas with unique potentials or limitations for use or development under various land uses. Examples of these relationships are given.

VIEW OF BUILDING 440 LOOKING WEST, NORTHWEST. BUILDING 440, THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF BUILDING 440 LOOKING WEST, NORTHWEST. BUILDING 440, THE TRANSPORT MODIFICATION CENTER, CONSISTS OF FOUR HIGH-BAY CORRUGATED METAL STRUCTURES. BUILDING 440 WAS USED FOR PACKAGING AND STAGING SPECIAL NUCLEAR MATERIALS AND DEPLETED URANIUM FOR SHIPMENT AND TO MODIFY VEHICLES TO MEET SPECIFIC UNITED STATES DEPARTMENT OF ENERGY REQUIREMENTS. (2/8/84) - Rocky Flats Plant, Transport Modification Center, North of Cactus Avenue, approximately 400 feet east of Third Street, Golden, Jefferson County, CO

Assessing energy efficiency of electric car bottom furnaces intended for thermal energization of minerals

NASA Astrophysics Data System (ADS)

Nizhegorodov, A. I.

2017-01-01

The paper deals with a new concept of electric furnaces for roasting and thermal energization of vermiculite and other minerals with vibrational transportation of a single-layer mass under constant thermal field. The paper presents performance calculation and comparative assessment of energy data for furnaces of different modifications: flame and electric furnaces with three units, furnaces with six units and ones with series-parallel connection of units, and furnaces of new concept.

A Closed-Loop Proportional-Integral (PI) Control Software for Fully Mechanically Controlled Automated Electron Microscopic Tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

REN, GANG; LIU, JINXIN; LI, HONGCHANG

A closed-loop proportional-integral (PI) control software is provided for fully mechanically controlled automated electron microscopic tomography. The software is developed based on Gatan DigitalMicrograph, and is compatible with Zeiss LIBRA 120 transmission electron microscope. However, it can be expanded to other TEM instrument with modification. The software consists of a graphical user interface, a digital PI controller, an image analyzing unit, and other drive units (i.e.: image acquire unit and goniometer drive unit). During a tomography data collection process, the image analyzing unit analyzes both the accumulated shift and defocus value of the latest acquired image, and provides the resultsmore » to the digital PI controller. The digital PI control compares the results with the preset values and determines the optimum adjustments of the goniometer. The goniometer drive unit adjusts the spatial position of the specimen according to the instructions given by the digital PI controller for the next tilt angle and image acquisition. The goniometer drive unit achieves high precision positioning by using a backlash elimination method. The major benefits of the software are: 1) the goniometer drive unit keeps pre-aligned/optimized beam conditions unchanged and achieves position tracking solely through mechanical control; 2) the image analyzing unit relies on only historical data and therefore does not require additional images/exposures; 3) the PI controller enables the system to dynamically track the imaging target with extremely low system error.« less

Mu-driven transposition of recombinant mini-Mu unit DNA in the Corynebacterium glutamicum chromosome.

PubMed

Gorshkova, Natalya V; Lobanova, Juliya S; Tokmakova, Irina L; Smirnov, Sergey V; Akhverdyan, Valerii Z; Krylov, Alexander A; Mashko, Sergey V

2018-03-01

A dual-component Mu-transposition system was modified for the integration/amplification of genes in Corynebacterium. The system consists of two types of plasmids: (i) a non-replicative integrative plasmid that contains the transposing mini-Mu(LR) unit bracketed by the L/R Mu ends or the mini-Mu(LER) unit, which additionally contains the enhancer element, E, and (ii) an integration helper plasmid that expresses the transposition factor genes for MuA and MuB. Efficient transposition in the C. glutamicum chromosome (≈ 2 × 10 -4 per cell) occurred mainly through the replicative pathway via cointegrate formation followed by possible resolution. Optimizing the E location in the mini-Mu unit significantly increased the efficiency of Mu-driven intramolecular transposition-amplification in C. glutamicum as well as in gram-negative bacteria. The new C. glutamicum genome modification strategy that was developed allows the consequent independent integration/amplification/fixation of target genes at high copy numbers. After integration/amplification of the first mini-Mu(LER) unit in the C. glutamicum chromosome, the E-element, which is bracketed by lox-like sites, is excised by Cre-mediated fashion, thereby fixing the truncated mini-Mu(LR) unit in its position for the subsequent integration/amplification of new mini-Mu(LER) units. This strategy was demonstrated using the genes for the citrine and green fluorescent proteins, yECitrine and yEGFP, respectively.

46 CFR 272.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Spare Parts. (h) Improvement means work to be performed on an Eligible Vessel which is a modification... self-contained operable units of machinery or equipment, as well as those items generally recognized...

46 CFR 272.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Spare Parts. (h) Improvement means work to be performed on an Eligible Vessel which is a modification... self-contained operable units of machinery or equipment, as well as those items generally recognized...

46 CFR 272.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Spare Parts. (h) Improvement means work to be performed on an Eligible Vessel which is a modification... self-contained operable units of machinery or equipment, as well as those items generally recognized...

Ultraviolet Imaging with Low Cost Smartphone Sensors: Development and Application of a Raspberry Pi-Based UV Camera.

PubMed

Wilkes, Thomas C; McGonigle, Andrew J S; Pering, Tom D; Taggart, Angus J; White, Benjamin S; Bryant, Robert G; Willmott, Jon R

2016-10-06

Here, we report, for what we believe to be the first time, on the modification of a low cost sensor, designed for the smartphone camera market, to develop an ultraviolet (UV) camera system. This was achieved via adaptation of Raspberry Pi cameras, which are based on back-illuminated complementary metal-oxide semiconductor (CMOS) sensors, and we demonstrated the utility of these devices for applications at wavelengths as low as 310 nm, by remotely sensing power station smokestack emissions in this spectral region. Given the very low cost of these units, ≈ USD 25, they are suitable for widespread proliferation in a variety of UV imaging applications, e.g., in atmospheric science, volcanology, forensics and surface smoothness measurements.

77 FR 22756 - Modification of Temporary Denial Order Making Temporary Denial of Export Privileges Applicable to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... Gatewick Freight & Cargo Services, a/k/a/ Gatewick Aviation Services, G 22 Dubai Airport Free Zone, P.O... Airport Free Zone, P.O. Box 393754, Dubai, United Arab Emirates; and P.O. Box 52404, Dubai, United Arab.... Kerman Aviation, a/k/a GIE Kerman Aviation, 42 Avenue Montaigne 75008, Paris, France. Sirjanco Trading, P...

19 CFR 205.6 - Investigations under section 301(e)(3) of the Trade Act of 1974.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Investigations under section 301(e)(3) of the Trade Act of 1974. 205.6 Section 205.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS TO DETERMINE THE PROBABLE ECONOMIC EFFECT ON THE ECONOMY OF THE UNITED STATES OF PROPOSED MODIFICATIONS OF...

19 CFR 205.6 - Investigations under section 301(e)(3) of the Trade Act of 1974.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Investigations under section 301(e)(3) of the Trade Act of 1974. 205.6 Section 205.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS TO DETERMINE THE PROBABLE ECONOMIC EFFECT ON THE ECONOMY OF THE UNITED STATES OF PROPOSED MODIFICATIONS OF...

40 CFR 60.1145 - What must I do with any public comments I receive during the public comment period on my siting...

Code of Federal Regulations, 2012 CFR

2012-07-01

... PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is Commenced After August 30, 1999 or for Which Modification or Reconstruction is... your municipal waste combustion unit. You must distribute the document at least to the main public...

Radiation quantities and units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-04-15

This report supersedes ICRU Report 19. Since ICRU Report 19 was published, a number of discussions have taken place between members of the Report Committee on Fundamental Quantities and Units and other workers in the field. Some of these discussions have resulted in the acceptance of certain modifications in the material set out in Report 19 and these modifications are incorporated in the current report. In addition, there has been some expansion and rearrangement of the material in the earlier report. In line, with providing more didactic material and useful source material for other ICRU reports, the general considerations inmore » subsection 1.A of Report 19 have been expanded and placed in a separate subsection. The additional material includes discussions of four terms that are used in this document - quantity, unit, stochastic, and non-stochastic - along with a brief discussion of the mathematical formalism used in ICRU reports. As in ICRU Report 19, the definitions of quantities and units specifically designed for radiation protection (Part B) are separated from those of the general quantities (Part A). The inclusion of the index concept outlined in ICRU Report 25(4) required an extension of Part B.« less

MAS2-8 radar and digital control unit

NASA Technical Reports Server (NTRS)

Oberg, J. M.; Ulaby, F. T.

1974-01-01

The design of the MAS 2-8 (2 to 8 GHz microwave-active spectrometer), a ground-based sensor system, is presented. A major modification in 1974 to the MAS 2-8, that of a control subsystem to automate the data-taking operation, is the prime focus. The digital control unit automatically changes all system parameters except FM rate and records the return signal on paper tape. The overall system operation and a detailed discussion of the design and operation of the digital control unit are presented.

AQUIFEM-SALT; a finite-element model for aquifers containing a seawater interface

USGS Publications Warehouse

Voss, C.I.

1984-01-01

Described are modifications to AQUIFEM, a finite element areal ground-water flow model for aquifer evaluation. The modified model, AQUIFEM-SALT, simulates an aquifer containing a freshwater body that freely floats on seawater. Parts of the freshwater lens may be confined above and below by less permeable units. Theory, code modifications, and model verification are discussed. A modified input data list is included. This report is intended as a companion to the original AQUIFEM documentation. (USGS)

Identification of histone modifications in biomedical text for supporting epigenomic research

PubMed Central

Kolářik, Corinna; Klinger, Roman; Hofmann-Apitius, Martin

2009-01-01

Background Posttranslational modifications of histones influence the structure of chromatine and in such a way take part in the regulation of gene expression. Certain histone modification patterns, distributed over the genome, are connected to cell as well as tissue differentiation and to the adaption of organisms to their environment. Abnormal changes instead influence the development of disease states like cancer. The regulation mechanisms for modifying histones and its functionalities are the subject of epigenomics investigation and are still not completely understood. Text provides a rich resource of knowledge on epigenomics and modifications of histones in particular. It contains information about experimental studies, the conditions used, and results. To our knowledge, no approach has been published so far for identifying histone modifications in text. Results We have developed an approach for identifying histone modifications in biomedical literature with Conditional Random Fields (CRF) and for resolving the recognized histone modification term variants by term standardization. For the term identification F1 measures of 0.84 by 10-fold cross-validation on the training corpus and 0.81 on an independent test corpus have been obtained. The standardization enabled the correct transformation of 96% of the terms from training and 98% from test the corpus. Due to the lack of terminologies exhaustively covering specific histone modification types, we developed a histone modification term hierarchy for use in a semantic text retrieval system. Conclusion The developed approach highly improves the retrieval of articles describing histone modifications. Since text contains context information about performed studies and experiments, the identification of histone modifications is the basis for supporting literature-based knowledge discovery and hypothesis generation to accelerate epigenomic research. PMID:19208128

Identification of histone modifications in biomedical text for supporting epigenomic research.

PubMed

Kolárik, Corinna; Klinger, Roman; Hofmann-Apitius, Martin

2009-01-30

Posttranslational modifications of histones influence the structure of chromatine and in such a way take part in the regulation of gene expression. Certain histone modification patterns, distributed over the genome, are connected to cell as well as tissue differentiation and to the adaption of organisms to their environment. Abnormal changes instead influence the development of disease states like cancer. The regulation mechanisms for modifying histones and its functionalities are the subject of epigenomics investigation and are still not completely understood. Text provides a rich resource of knowledge on epigenomics and modifications of histones in particular. It contains information about experimental studies, the conditions used, and results. To our knowledge, no approach has been published so far for identifying histone modifications in text. We have developed an approach for identifying histone modifications in biomedical literature with Conditional Random Fields (CRF) and for resolving the recognized histone modification term variants by term standardization. For the term identification F1 measures of 0.84 by 10-fold cross-validation on the training corpus and 0.81 on an independent test corpus have been obtained. The standardization enabled the correct transformation of 96% of the terms from training and 98% from test the corpus. Due to the lack of terminologies exhaustively covering specific histone modification types, we developed a histone modification term hierarchy for use in a semantic text retrieval system. The developed approach highly improves the retrieval of articles describing histone modifications. Since text contains context information about performed studies and experiments, the identification of histone modifications is the basis for supporting literature-based knowledge discovery and hypothesis generation to accelerate epigenomic research.

Adherence to recommended lifestyle modifications and factors associated for hypertensive patients attending chronic follow-up units of selected public hospitals in Addis Ababa, Ethiopia

PubMed Central

Tibebu, Abel; Mengistu, Daniel; Negesa, Lemma

2017-01-01

Introduction One of the most prevalent noncommunicable diseases is hypertension (HTN). The availability of effective antihypertensive medications does not result in the expected outcomes in terms of controlling blood pressure. The rationale for these and other findings of uncontrolled HTN points toward poor adherence. The most neglected causes of uncontrolled HTN are unhealthy lifestyles. Few studies have been conducted to show the gap and magnitude of self-management adherence. Objective This study aimed to assess adherence to recommended lifestyle modifications of hypertensive patients undergoing follow-up at chronic follow-up units of public health hospitals in Addis Ababa, Ethiopia, 2016. Methods Institutional-based cross-sectional study was conducted in four public health hospitals which were selected by drawing lots. Systematic random sampling was used to select study subjects. The results of the descriptive statistics were expressed as percentages and frequencies. Associations between lifestyle modification and independent variables were ana-lyzed using bivariate and multivariate logistic regression analysis. The study was conducted from February 15, 2016 to April 15, 2016. Results The study included 404 respondents with a 97% response rate; 210 (52%) were male and the mean age was 54.00±10.77 years. The respondents’ adherence to lifestyle modifications was 23%. The lifestyle adherence was found to be better in females, patients who had comorbidities, and had been knowledgeable about the disease and was poor among young adult respondents. Conclusion The rates of adherence to lifestyle changes were generally found to be low. Educational sessions that especially focus on lifestyle modifications and ongoing support for patients should be designed and studies which assess all the components of self-management should be conducted for comparison among different subgroups. PMID:28280305

Dish Stirling solar receiver program

NASA Technical Reports Server (NTRS)

Haglund, R. A.

1980-01-01

A technology demonstration of a Dish Stirling solar thermal electric system can be accomplished earlier and at a much lower cost than previous planning had indicated by employing technical solutions that allow already existing hardware, with minimum modifications, to be integrated into a total system with a minimum of development. The DSSR operates with a modified United Stirling p-40 engine/alternator and the JPL Test Bed Concentrator as a completely integrated solar thermal electric system having a design output of 25 kWe. The system is augmented by fossil fuel combustion which ensures a continuous electrical output under all environmental conditions. Technical and economic studies by government and industry in the United States and abroad identify the Dish Stirling solar electric system as the most appropriate, efficient and economical method for conversion of solar energy to electricity in applications when the electrical demand is 10 MWe and less.

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy (left) looks at an external tank door corrosion work being done on Endeavour. At right, Tom Roberts, Airframe Engineering System specialist with United Space Alliance, is describing the work. At right is Kathy Laufenberg, Orbiter Airframe Engineering ground area manager,also with USA. Endeavour is in its Orbiter Major Modification period, which began in December 2003.

NASA Image and Video Library

2004-02-25

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy (left) looks at an external tank door corrosion work being done on Endeavour. At right, Tom Roberts, Airframe Engineering System specialist with United Space Alliance, is describing the work. At right is Kathy Laufenberg, Orbiter Airframe Engineering ground area manager,also with USA. Endeavour is in its Orbiter Major Modification period, which began in December 2003.

The vastus lateralis neuromuscular activity during all-out cycling exercise.

PubMed

Bercier, Stephane; Halin, Renaud; Ravier, Philippe; Kahn, Jean-Francois; Jouanin, Jean-Claude; Lecoq, Anne-Marie; Buttelli, Olivier

2009-10-01

The objective of this work was to study modifications in motor control through surface electromyographic (sEMG) activity during a very short all-out cycling exercise. Twelve male cyclists (age 23+/-4 years) participated in this study. After a warm-up period, each subject performed three all-out cycling exercises of 6s separated by 2 min of complete rest. This protocol was repeated three times with a minimum of 2 days between each session. The braking torque imposed on cycling motion was 19 Nm. The sEMG of the vastus lateralis was recorded during the first seven contractions of the sprint. Time-frequency analysis of sEMG was performed using continuous wavelet transform. The mean power frequency (MPF, qualitative modifications in the recruitment of motor units) and signal energy (a quantitative indicator of modifications in the motor units recruitment) were computed for the frequency range 10-500 Hz. sEMG energy increased (P0.05) between contraction number 1 and 2, decreased (P < or =0.05) between contraction number 2 and 3 then stabilized between contraction number 3 and 7 during the all-out test. MPF increased (P < or =0.05) during the all-out test. This increase was more marked during the first two contractions. The decrease in energy and the increase in the sEMG MPF suggest a large spatial recruitment of motor units (MUs) at the beginning of the sprint followed by a preferential recruitment of faster MUs at the end of the sprint, respectively.

Engineering Large Animal Species to Model Human Diseases.

PubMed

Rogers, Christopher S

2016-07-01

Animal models are an important resource for studying human diseases. Genetically engineered mice are the most commonly used species and have made significant contributions to our understanding of basic biology, disease mechanisms, and drug development. However, they often fail to recreate important aspects of human diseases and thus can have limited utility as translational research tools. Developing disease models in species more similar to humans may provide a better setting in which to study disease pathogenesis and test new treatments. This unit provides an overview of the history of genetically engineered large animals and the techniques that have made their development possible. Factors to consider when planning a large animal model, including choice of species, type of modification and methodology, characterization, production methods, and regulatory compliance, are also covered. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Implementation of NGA-West2 ground motion models in the 2014 U.S. National Seismic Hazard Maps

USGS Publications Warehouse

Rezaeian, Sanaz; Petersen, Mark D.; Moschetti, Morgan P.; Powers, Peter; Harmsen, Stephen C.; Frankel, Arthur D.

2014-01-01

The U.S. National Seismic Hazard Maps (NSHMs) have been an important component of seismic design regulations in the United States for the past several decades. These maps present earthquake ground shaking intensities at specified probabilities of being exceeded over a 50-year time period. The previous version of the NSHMs was developed in 2008; during 2012 and 2013, scientists at the U.S. Geological Survey have been updating the maps based on their assessment of the “best available science,” resulting in the 2014 NSHMs. The update includes modifications to the seismic source models and the ground motion models (GMMs) for sites across the conterminous United States. This paper focuses on updates in the Western United States (WUS) due to the use of new GMMs for shallow crustal earthquakes in active tectonic regions developed by the Next Generation Attenuation (NGA-West2) project. Individual GMMs, their weighted combination, and their impact on the hazard maps relative to 2008 are discussed. In general, the combined effects of lower medians and increased standard deviations in the new GMMs have caused only small changes, within 5–20%, in the probabilistic ground motions for most sites across the WUS compared to the 2008 NSHMs.

Development of Flexi-Burn™ CFB Power Plant to Meet the Challenge of Climate Change

NASA Astrophysics Data System (ADS)

Hackt, Horst; Fant, Zhen; Seltzert, Andrew; Hotta, Arto; Erikssoni, Timo; Sippu, Ossi

Carbon-dioxide capture and storage (CCS) offers the potential for major reductions in carbon- dioxide emissions of fossil fuel-based power generation in the fairly short term, and oxyfuel combustion is one of the identified CCS technology options. Foster Wheeler (FW) is working on reduction of carbon-dioxide with its integrated Flexi-Burn™ CFB technology. The proven high efficiency circulating fluidized-bed (CFB) technology, when coupled with air separation units and carbon purification units, offers a solution for carbon dioxide reduction both in re-powering and in greenfield power plants. CFB technology has the advantages over pulverized coal technology of a more uniform furnace heat flux, increased fuel flexibility and offers the opportunity to further reduce carbon dioxide emissions by co-firing coal with bio-fuels. Development and design of an integrated Flexi-Bum™ CFB steam generator and balance of plant system was conducted for both air mode and oxyfuel mode. Through proper configuration and design, the same steam generator can be switched from air mode to oxyfuel mode without the need for unit shutdown for modifications. The Flexi-Burn™ CFB system incorporates features to maximize plant efficiency and power output when operating in the oxy-firing mode through firing more fuel in the same boiler.

Information Access in Rural Areas of the United States: The Public Library's Role in the Digital Divide and the Implications of Differing State Funding Models

ERIC Educational Resources Information Center

Thiele, Jennifer

2016-01-01

In the United States, individual states have different means of determining and distributing funding. This influences library service and access to information particularly as it pertains to critical Internet access. Funding and service trends have changed, especially as it relates to public libraries, with some modifications working to their…

78 FR 41425 - In the Matter of Duke Energy Carolinas, LLC; (Oconee Nuclear Station, Units 1, 2, and 3...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... SSF diesel generator during a fire for which the SSF is credited. This modification along with... SSF equipment in the event of a failure of the SSF diesel generator during a fire for which the SSF is... provide water to the steam generators of all three units sufficient to remove decay heat following...

Battery Test Manual For Electric Vehicles, Revision 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christophersen, Jon P.

2015-06-01

This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Office. It is based on technical targets for commercial viability established for energy storage development projects aimed at meeting system level DOE goals for Electric Vehicles (EV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for EVs. However, it does share some methods described in the previously published battery test manual for plug-in hybrid electric vehicles. Due to the complexity of some of themore » procedures and supporting analysis, future revisions including some modifications and clarifications of these procedures are expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices. The DOE-United States Advanced Battery Consortium (USABC), Technical Advisory Committee (TAC) supported the development of the manual. Technical Team points of contact responsible for its development and revision are Chul Bae of Ford Motor Company and Jon P. Christophersen of the Idaho National Laboratory. The development of this manual was funded by the Unites States Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Technical direction from DOE was provided by David Howell, Energy Storage R&D Manager and Hybrid Electric Systems Team Leader. Comments and questions regarding the manual should be directed to Jon P. Christophersen at the Idaho National Laboratory (jon.christophersen@inl.gov).« less

Circulating water traveling screen modifications to improve impinged fish survival and debris handling at Salem Generating Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ronafalvy, J.P.; Cheesman, R.R.; Matejek, W.M.

This paper summarizes modifications made to the Salem Generating Station`s (Salem) Circulating Water Traveling Screens (CWTS) as required by Salem`s New Jersey Pollutant Discharge Elimination System Permit (NJPDES Permit). The modifications incorporated newly designed CWTS baskets with hydrodynamically improved fish buckets (greatly reduced turbulence in the bucket); smooth woven mesh screens with 0.250 x 0.500 inch rectangular mesh openings (formerly 0.375 inch square mesh openings); lighter composite basket frame material allowing increased screen rotation speed; improved low and high pressure spray wash patterns; improved screen to sluice trough flap seal design and miscellaneous reliability improvements. In order to address themore » overall effects of the CWTS modifications on fish losses, the effect of both entrainment and impingement by fish size was addressed in a comparison study between modified and unmodified units. The results of the assessment indicate a 51% reduction in overall weakfish (Cynoscion regales) losses (expressed as equivalent adults, larger than 187 mm total length individuals). These modifications also enhanced debris removal capability of the CWTSs. 5 refs., 5 figs.« less

An epigenetic view of developmental diseases: new targets, new therapies.

PubMed

Xie, Pei; Zang, Li-Qun; Li, Xue-Kun; Shu, Qiang

2016-08-01

Function of epigenetic modifications is one of the most competitive fields in life science. Over the past several decades, it has been revealed that epigenetic modifications play essential roles in development and diseases including developmental diseases. In the present review, we summarize the recent progress about the function of epigenetic regulation, especially DNA and RNA modifications in developmental diseases. Original research articles and literature reviews published in PubMed-indexed journals. DNA modifications including methylation and demethylation can regulate gene expression, and are involved in development and multiple diseases including Rett syndrome, Autism spectrum disorders, congenital heart disease and cancer, etc. RNA methylation and demethylation play important roles in RNA processing, reprogramming, circadian, and neuronal activity, and then modulate development. DNA and RNA modifications play important roles in development and diseases through regulating gene expression. Epigenetic components could serve as novel targets for the treatment of developmental diseases.

CNTs in polymer melt: The influence on dispersion by sonication

NASA Astrophysics Data System (ADS)

Bischoff, M.; Köhler, T.; Bandelin, J.; Möhricke, J.; Jung, R.; Gries, T.

2017-10-01

Nanocomposites have become more important as the implementation of nanoparticles in polymer allows additional functions in common industrial parts. Especially in the fabrication of filaments or fibres nanomodification is crucial, as only very small fillers can be added to the very fine fibres (common fibre diameter is 20 μm, fine filaments are 1 μm). [1,2] Discharging fibres, conductive fibres and many other functional fibres raise in their importance nowadays, as the need for highly functional but flexible surfaces, such as textiles rises. Especially the dispersion quality is essential for the final enhancement of the filament properties. Homogeneously distributed particles serve function throughout the full fibre giving equal mechanical and functional properties over the length of the fibre and of the manufactured textile [3,4]. Counteracting this requirement nanoparticles tend to form agglomerates due to their high specific surface area during the manufacturing of those nanocomposites [5]. In this paper the distribution and dispersion methods are introduced. The homogenization of carbon nanoparticles in polymer melt is enhanced by a novel sonication unit of ITA and BANDELIN electronic GmbH & Co. KG. The first development steps of the semi-industrial unit fabrication as well as the first experimental results in the lab scale of the modification of the dispersion will be shown. Special focus will be laid on the sealing of the new sonication unit as well as the positioning and equipment size when being implemented in an existing melt spinning unit. The paper will show the status of the project as well as the next steps, to show other participants the potential of the newly developed unit.

"Mitochondrial Replacement" Technologies and Human Germline Nuclear Modification.

PubMed

Lane, Alyssa; Nisker, Jeff

2016-08-01

In 2015 the United Kingdom became the first jurisdiction to approve "mitochondrial replacement techniques" (MRT), thereby dropping prohibitions against creating human embryos with a permanently altered genetic make-up for purposes of reproduction. MRT is a misnomer because in fact it is the nucleus of the oocyte of the woman who wants a genetically related child that is transferred to the enucleated oocyte of a woman paid to undergo IVF to provide the oocyte. MRT thus constitutes nuclear transfer, which is prohibited by criminal sanctions under sections of laws on reproductive cloning in Canada, the United States, Australia, and European countries that regulate assisted reproduction. By adopting policies permitting the use of MRT, the United Kingdom has become the first jurisdiction to counteract an international consensus prohibiting germline modification. Analyses of the legal, ethical, and societal implications of MRT in assisted human reproduction are essential. Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.

15 CFR 2011.103 - Entry into the United States.

Code of Federal Regulations, 2010 CFR

2010-01-01

... percent. Such tolerance may be modified by the Secretary if the Secretary finds that such modification is... amount of sugar (raw value) entered is determined fo purposes of administering the quota. [55 FR 40648...

28 CFR 527.46 - Receiving United States citizens from other countries.

Code of Federal Regulations, 2010 CFR

2010-07-01

... appropriate, competent judicial authority of the transferring country and any modifications thereof; (2) A... credits to which the offender is entitled, such as work done, good behavior, pre-trial confinement, etc...

77 FR 27612 - Modifications to Definition of United States Property

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... the total combined voting power of which, immediately after the CFC's acquisition of stock in such... margin payment made on a daily or intraday basis between the counterparties to a contract to protect...

Architecture and data processing alternatives for the TSE computer. Volume 3: Execution of a parallel counting algorithm using array logic (Tse) devices

NASA Technical Reports Server (NTRS)

Metcalfe, A. G.; Bodenheimer, R. E.

1976-01-01

A parallel algorithm for counting the number of logic-l elements in a binary array or image developed during preliminary investigation of the Tse concept is described. The counting algorithm is implemented using a basic combinational structure. Modifications which improve the efficiency of the basic structure are also presented. A programmable Tse computer structure is proposed, along with a hardware control unit, Tse instruction set, and software program for execution of the counting algorithm. Finally, a comparison is made between the different structures in terms of their more important characteristics.

Functional Performance of an Enabling Atmosphere Revitalization Subsystem Architecture for Deep Space Exploration Missions

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Abney, Morgan B.; Frederick, Kenneth R.; Greenwood, Zachary W.; Kayatin, Matthew J.; Newton, Robert L.; Parrish, Keith J.; Roman, Monsi C.; Takada, Kevin C.; Miller, Lee A.;

Genome Modification Technologies and Their Applications in Avian Species.

PubMed

Lee, Hong Jo; Kim, Young Min; Ono, Tamao; Han, Jae Yong

2017-10-26

The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as lentiviral systems and piggyBac transposition have been used to produce transgenic birds for diverse purposes. In recent years, newly developed programmable genome editing tools such as transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) have also been successfully adopted in avian systems with primordial germ cell (PGC)-mediated genome modification. These genome modification technologies are expected to be applied to practical uses beyond system development itself. The technologies could be used to enhance economic traits in poultry such as acquiring a disease resistance or producing functional proteins in eggs. Furthermore, novel avian models of human diseases or embryonic development could also be established for research purposes. In this review, we discuss diverse genome modification technologies used in avian species, and future applications of avian biotechnology.

Genome Modification Technologies and Their Applications in Avian Species

PubMed Central

Lee, Hong Jo; Kim, Young Min; Ono, Tamao

2017-01-01

The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as lentiviral systems and piggyBac transposition have been used to produce transgenic birds for diverse purposes. In recent years, newly developed programmable genome editing tools such as transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) have also been successfully adopted in avian systems with primordial germ cell (PGC)-mediated genome modification. These genome modification technologies are expected to be applied to practical uses beyond system development itself. The technologies could be used to enhance economic traits in poultry such as acquiring a disease resistance or producing functional proteins in eggs. Furthermore, novel avian models of human diseases or embryonic development could also be established for research purposes. In this review, we discuss diverse genome modification technologies used in avian species, and future applications of avian biotechnology. PMID:29072628

A noninvasive technique for real-time detection of bruises in apple surface based on machine vision

NASA Astrophysics Data System (ADS)

Zhao, Juan; Peng, Yankun; Dhakal, Sagar; Zhang, Leilei; Sasao, Akira

2013-05-01

Apple is one of the highly consumed fruit item in daily life. However, due to its high damage potential and massive influence on taste and export, the quality of apple has to be detected before it reaches the consumer's hand. This study was aimed to develop a hardware and software unit for real-time detection of apple bruises based on machine vision technology. The hardware unit consisted of a light shield installed two monochrome cameras at different angles, LED light source to illuminate the sample, and sensors at the entrance of box to signal the positioning of sample. Graphical Users Interface (GUI) was developed in VS2010 platform to control the overall hardware and display the image processing result. The hardware-software system was developed to acquire the images of 3 samples from each camera and display the image processing result in real time basis. An image processing algorithm was developed in Opencv and C++ platform. The software is able to control the hardware system to classify the apple into two grades based on presence/absence of surface bruises with the size of 5mm. The experimental result is promising and the system with further modification can be applicable for industrial production in near future.

Data management system CIU and DIU. Appendix A: CIU and DIU schematics

NASA Technical Reports Server (NTRS)

1975-01-01

The Computer Interface Unit (CIU) and the Data Interface Unit (DIU) of the Data Management System (DMS) were described as to their functional location, purpose and function. This describes the CIU and DIU at the unit level illustrating their interface thru the Data Bus (DBUS) and to other DMS units. All unit level interfaces are defined as to function and characteristics. The controls, indicators, test points and connectors are listed and function, location and application are described for each. The mechanical configuration is defined and illustrated to provide card and component location for modification or repair purposes. Unique disassembly and assembly requirements are outlined where applicable. A unit internal functional block diagram level description is provided.

The pharmacological treatment and management of obesity.

PubMed

Hussain, Syed Sufyan; Bloom, Stephen Robert

2011-01-01

Obesity is a pandemic with many complications that increase the societal disease burden and cost of health care, and decrease longevity and quality of life. Currently, 1 in 3 adults in the United States is obese. Physicians must therefore regularly confront obesity and its consequent diseases, and develop strategies for effective treatment and management. This article summarizes current lifestyle modifications, pharmacological treatment, and surgical options for the management of obesity and discusses the benefits, limitations, and risks of each. As insights are gained into the pathophysiology of a gut-brain neurochemical feedback axis governing satiety and feeding behavior, targets for new pharmacotherapies are being developed. In particular, gut hormone analogs are an attractive antiobesity therapy because they appear to lack the adverse effects historically associated with central nervous system-acting agents.

Ultraviolet Imaging with Low Cost Smartphone Sensors: Development and Application of a Raspberry Pi-Based UV Camera

PubMed Central

Wilkes, Thomas C.; McGonigle, Andrew J. S.; Pering, Tom D.; Taggart, Angus J.; White, Benjamin S.; Bryant, Robert G.; Willmott, Jon R.

2016-01-01

Here, we report, for what we believe to be the first time, on the modification of a low cost sensor, designed for the smartphone camera market, to develop an ultraviolet (UV) camera system. This was achieved via adaptation of Raspberry Pi cameras, which are based on back-illuminated complementary metal-oxide semiconductor (CMOS) sensors, and we demonstrated the utility of these devices for applications at wavelengths as low as 310 nm, by remotely sensing power station smokestack emissions in this spectral region. Given the very low cost of these units, ≈ USD 25, they are suitable for widespread proliferation in a variety of UV imaging applications, e.g., in atmospheric science, volcanology, forensics and surface smoothness measurements. PMID:27782054

Characterization of fast neutron spectrum in the TRIGA for hardness testing of electronic components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, George W.

1986-07-01

Argonne National Laboratory-West, operated by the University of Chicago, is located near Idaho Falls, ID, on the Idaho National Engineering Laboratory Site. ANL-West performs work in support of the Liquid Metal Fast Breeder Reactor Program (LMFBR) sponsored by the United States Department of Energy. The NRAD reactor is located at the Argonne Site within the Hot Fuel Examination Facility/North, a large hot cell facility where both non-destructive and destructive examinations are performed on highly irradiated reactor fuels and materials in support of the LMFBR program. The NRAD facility utilizes a 250-kW TRIGA reactor and is completely dedicated to neutron radiographymore » and the development of radiography techniques. Criticality was first achieved at the NRAD reactor in October of 1977. Since that time, a number of modifications have been implemented to improve operational efficiency and radiography production. This paper describes the modifications and changes that significantly improved operational efficiency and reliability of the reactor and the essential auxiliary reactor systems. (author)« less

Data management system DIU test system

NASA Technical Reports Server (NTRS)

1976-01-01

An operational and functional description is given of the data management system. Descriptions are included for the test control unit, analog stimulus panel, discrete stimulus panel, and the precision source. The mechanical configuration is defined and illustrated to provide card and component location for modification or repair. The unit level interfaces are mirror images of the DIU interfaces and are described in the Final Technical Report for NASA-MSFC contract NAS8-29155.

Diagnosing causes of increased NO{sub x} at Potomac River Unit 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

D`Agostini, M.; Levy, E.; Blankenship, D.

1996-12-31

Potomac River Unit 4, a 108 MW unit, has a corner-fired boiler with conventional burners. Through the use of combustion optimization techniques, the NO{sub x} emissions had been reduced from baseline levels of 0.6 lb/MBtu to values below 0.45 lb/MBtu over the load range, and had been routinely dispatched at this reduced emissions level for extended periods of operation. After a scheduled outage in Fall 1995 for boiler maintenance, windbox modifications and a superheater replacement, the unit was returned to service, and it was found that the full-load NO{sub x} level had increased by approximately 0.1 lb/MBtu. A week ofmore » tests was performed and pre- and post-outage data analyzed to determine the factors contributing to the increase in NO{sub x} emissions. The principal cause was found to be a reduction in the amount of boiler air in-leakage arising from boiler casing repairs, and leading to higher air-to-fuel ratios in the furnace. Other, secondary, causes were also determined. Results from the analysis indicate the windbox modifications were actually effective in reducing NO{sub x}, although the benefits were obscured due to the intervening circumstances. This paper describes the diagnostic process which was followed and discusses the findings from the investigation.« less

The Interaction between Epigenetics, Nutrition and the Development of Cancer

PubMed Central

Bishop, Karen S.; Ferguson, Lynnette R.

2015-01-01

Unlike the genome, the epigenome can be modified and hence some epigenetic risk markers have the potential to be reversed. Such modifications take place by means of drugs, diet or environmental exposures. It is widely accepted that epigenetic modifications take place during early embryonic and primordial cell development, but it is also important that we gain an understanding of the potential for such changes later in life. These “later life” epigenetic modifications in response to dietary intervention are the focus of this paper. The epigenetic modifications investigated include DNA methylation, histone modifications and the influence of microRNAs. The epigenotype could be used not only to predict susceptibility to certain cancers but also to assess the effectiveness of dietary modifications to reduce such risk. The influence of diet or dietary components on epigenetic modifications and the impact on cancer initiation or progression has been assessed herein. PMID:25647662

Exploring Quadratic Functions with Logger "Pro"

ERIC Educational Resources Information Center

Pope, Derek

2018-01-01

The author shares the lesson that he used to introduce the quadratic unit to students in an extended second-year algebra class, demonstrate why it was appropriate for his struggling learners, and discuss possible future modifications to this lesson.

The incorporation of plotting capability into the Unified Subsonic Supersonic Aerodynamic Analysis program, version B

NASA Technical Reports Server (NTRS)

Winter, O. A.

1980-01-01

The B01 version of the United Subsonic Supersonic Aerodynamic Analysis program is the result of numerous modifications and additions made to the B00 version. These modifications and additions affect the program input, its computational options, the code readability, and the overlay structure. The following are described: (1) the revised input; (2) the plotting overlay programs which were also modified, and their associated subroutines, (3) the auxillary files used by the program, the revised output data; and (4) the program overlay structure.

Misuse and modification of fireworks with fatal injury.

PubMed

Fulcher, James; Luttrell, Harrison; Harvey, Whit; Ward, Michael

2015-06-01

Fireworks deaths are a rare event in the United States with minor injuries comprising most adverse events. We report the case of misuse and modification of a large "mortar" firework with fatal results. In this case, the firework charge was modified with additional fuses and placed into the launcher upside down. The decedent then held the mortar base closely to his chest and lit the modified fuse. The resulting explosion caused severe blunt force trauma with significant hydrostatic shock damage to the heart and liver. This cause highlights the dangers of fireworks, particularly when misused.

Rolling scheduling of electric power system with wind power based on improved NNIA algorithm

NASA Astrophysics Data System (ADS)

Xu, Q. S.; Luo, C. J.; Yang, D. J.; Fan, Y. H.; Sang, Z. X.; Lei, H.

2017-11-01

This paper puts forth a rolling modification strategy for day-ahead scheduling of electric power system with wind power, which takes the operation cost increment of unit and curtailed wind power of power grid as double modification functions. Additionally, an improved Nondominated Neighbor Immune Algorithm (NNIA) is proposed for solution. The proposed rolling scheduling model has further improved the operation cost of system in the intra-day generation process, enhanced the system’s accommodation capacity of wind power, and modified the key transmission section power flow in a rolling manner to satisfy the security constraint of power grid. The improved NNIA algorithm has defined an antibody preference relation model based on equal incremental rate, regulation deviation constraints and maximum & minimum technical outputs of units. The model can noticeably guide the direction of antibody evolution, and significantly speed up the process of algorithm convergence to final solution, and enhance the local search capability.

Solid state recording current meter conversion

USGS Publications Warehouse

Cheng, Ralph T.; Wang, Lichen

1985-01-01

The authors describe the conversion of an Endeco-174 current meter to a solid-state recording current meter. A removable solid-state module was designed to fit in the space originally occupied by an 8-track tape cartridge. The module contains a CPU and 128 kilobytes of nonvolatile CMOS memory. The solid-state module communicates with any terminal or computer using an RS-232C interface at 4800 baud rate. A primary consideration for conversion was to keep modifications of the current meter to a minimum. The communication protocol was designed to emulate the Endeco tape translation unit, thus the need for a translation unit was eliminated and the original data reduction programs can be used without any modification. After conversion, the data recording section of the current meter contains no moving parts; the storage capacity of the module is equivalent to that of the original tape cartridge.

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy and Deputy Director Woodrow Whitlow Jr. (center, left and right) talk with Kathy Laufenberg, Orbiter Airframe Engineering ground rea manager, and Tom Roberts, Airframe Engineering System specialist, both with United Space Alliance. At far right is Bruce Buckingham, assistant to Dr. Whitlow. They are standing in front of the aft base heatshield of Endeavour, which is in its Orbiter Major Modification period that began in December 2003.

NASA Image and Video Library

2004-02-25

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy and Deputy Director Woodrow Whitlow Jr. (center, left and right) talk with Kathy Laufenberg, Orbiter Airframe Engineering ground rea manager, and Tom Roberts, Airframe Engineering System specialist, both with United Space Alliance. At far right is Bruce Buckingham, assistant to Dr. Whitlow. They are standing in front of the aft base heatshield of Endeavour, which is in its Orbiter Major Modification period that began in December 2003.

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy and Deputy Director Woodrow Whitlow Jr. (center, left and right) talk with Kathy Laufenberg, Orbiter Airframe Engineering ground area manager, and Tom Roberts, Airframe Enginering System specialist, both with United Space Alliance. At far right is Bruce Buckingham, assistant to Dr. Whitlow. They are standing in front of the aft base heatshield of Endeavour, which is in its Orbiter Major Modification period that began in December 2003.

NASA Image and Video Library

2004-02-25

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy and Deputy Director Woodrow Whitlow Jr. (center, left and right) talk with Kathy Laufenberg, Orbiter Airframe Engineering ground area manager, and Tom Roberts, Airframe Enginering System specialist, both with United Space Alliance. At far right is Bruce Buckingham, assistant to Dr. Whitlow. They are standing in front of the aft base heatshield of Endeavour, which is in its Orbiter Major Modification period that began in December 2003.

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy (left) listens to Kathy Laufenberg, Orbiter Airframe Engineering ground area manager, with United Space Alliance, about corrosion work being done on the external tank door of orbiter Endeavour. On either side of Laufenberg are Tom Roberts, Airframe Engineering System specialist, also with USA, and Joy Huff, with KSC Space Shuttle Processing. Endeavour is in its Orbiter Major Modification period, which began in December 2003.

NASA Image and Video Library

2004-02-25

KENNEDY SPACE CENTER, FLA. - On a tour of the Orbiter Processing Facility, Center Director Jim Kennedy (left) listens to Kathy Laufenberg, Orbiter Airframe Engineering ground area manager, with United Space Alliance, about corrosion work being done on the external tank door of orbiter Endeavour. On either side of Laufenberg are Tom Roberts, Airframe Engineering System specialist, also with USA, and Joy Huff, with KSC Space Shuttle Processing. Endeavour is in its Orbiter Major Modification period, which began in December 2003.

Modification split type air conditioning unit by installing internal heat exchanger and condenser precooling

NASA Astrophysics Data System (ADS)

Ambarita, H.

2018-03-01

In this paper, a modified of air conditioning (AC) system is proposed. In the modified system, an internal heat exchanger and condenser precooling unit are installed. The objective is to explore the effect of the additional equipment to the performance of the system. An AC with compressor power of 1 PK is modified and compared with the original one. The results show that ER of the modified system is higher than the original one in order of 3.6%. The work of the compressor of the modified system is 12.5% lower than work of the compressor without modification. Finally, the COP of the modified system is 11.71% higher than the original one. These facts reveal that the combination of IHX and condenser precooling shows positive impact on the performance of the AC. It is recommended to use the modified system to improve the energy efficiency of the Air Conditioning system.

Conversion of an 800 MW oil fired generating unit to burn Orimulsion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blum, J.; Halpin, M.; Morgan, D.

1998-07-01

Florida Power and Light Company (FPL) is proposing to convert the two existing 800 megawatt (MW) residual oil fired generating units at its Manatee Plant located in Parrish, Florida, to burn Ormulsion. Ormulsion is the registered trademark name for a mixture of water and a naturally occurring heavy hydrocarbon known as bitumen. Orimulsion, which originates in Venezuela, will be shipped to Port Manatee in double-hulled vessels, stored at FPL's existing Port Manatee Terminal, and transported via FPL's existing fuel pipeline to the Manatee Plant. The proposed conversion involves modifications of the existing fuel handling facilities, enhancements of the boiler heatmore » transfer surfaces and soot blowing system, and addition of new pollution control equipment. The Manatee Orimulsion conversion will result in overall environmental benefits and significant savings to FPL's customers. This paper summarizes the overall objectives of the project and briefly describes these modifications.« less

Conversion of an 800 MW oil fired generating unit to burn Orimulsion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blum, J.; Halpin, M.; Morgan, D.

1998-04-01

Florida Power & Light Company (FPL) is proposing to convert the two existing 800 megawatt (MW) residual oil fired generating units at its Manatee Plant located in Parrish, Florida, to burn Orimulsion. Orimulsion is the registered trademark name for a mixture of water and a naturally occurring heavy hydrocarbon known as bitumen. Orimulsion, which originates in Venezuela, will be shipped to Port Manatee in double-hulled vessels, stored at FPL`s existing Port Manatee Terminal, and transported via FPL`s existing fuel pipeline to the Manatee Plant. The proposed conversion involves modifications of the existing fuel handling facilities, enhancements of the boiler heatmore » transfer surfaces and soot blowing system, and addition of new pollution control equipment. The Manatee Orimulsion conversion will result in overall environmental benefits and significant savings to FPL`s customers. This paper summarizes the overall objectives of the project and briefly describes these modifications.« less

Development of a Groundwater Transport Simulation Tool for Remedial Process Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ivarson, Kristine A.; Hanson, James P.; Tonkin, M.

2015-01-14

The groundwater remedy for hexavalent chromium at the Hanford Site includes operation of five large pump-and-treat systems along the Columbia River. The systems at the 100-HR-3 and 100-KR-4 groundwater operable units treat a total of about 9,840 liters per minute (2,600 gallons per minute) of groundwater to remove hexavalent chromium, and cover an area of nearly 26 square kilometers (10 square miles). The pump-and-treat systems result in large scale manipulation of groundwater flow direction, velocities, and most importantly, the contaminant plumes. Tracking of the plumes and predicting needed system modifications is part of the remedial process optimization, and is amore » continual process with the goal of reducing costs and shortening the timeframe to achieve the cleanup goals. While most of the initial system evaluations are conducted by assessing performance (e.g., reduction in contaminant concentration in groundwater and changes in inferred plume size), changes to the well field are often recommended. To determine the placement for new wells, well realignments, and modifications to pumping rates, it is important to be able to predict resultant plume changes. In smaller systems, it may be effective to make small scale changes periodically and adjust modifications based on groundwater monitoring results. Due to the expansive nature of the remediation systems at Hanford, however, additional tools were needed to predict the plume reactions to system changes. A computer simulation tool was developed to support pumping rate recommendations for optimization of large pump-and-treat groundwater remedy systems. This tool, called the Pumping Optimization Model, or POM, is based on a 1-layer derivation of a multi-layer contaminant transport model using MODFLOW and MT3D.« less

Knowledge-based system verification and validation

NASA Technical Reports Server (NTRS)

Johnson, Sally C.

1990-01-01

The objective of this task is to develop and evaluate a methodology for verification and validation (V&V) of knowledge-based systems (KBS) for space station applications with high reliability requirements. The approach consists of three interrelated tasks. The first task is to evaluate the effectiveness of various validation methods for space station applications. The second task is to recommend requirements for KBS V&V for Space Station Freedom (SSF). The third task is to recommend modifications to the SSF to support the development of KBS using effectiveness software engineering and validation techniques. To accomplish the first task, three complementary techniques will be evaluated: (1) Sensitivity Analysis (Worchester Polytechnic Institute); (2) Formal Verification of Safety Properties (SRI International); and (3) Consistency and Completeness Checking (Lockheed AI Center). During FY89 and FY90, each contractor will independently demonstrate the user of his technique on the fault detection, isolation, and reconfiguration (FDIR) KBS or the manned maneuvering unit (MMU), a rule-based system implemented in LISP. During FY91, the application of each of the techniques to other knowledge representations and KBS architectures will be addressed. After evaluation of the results of the first task and examination of Space Station Freedom V&V requirements for conventional software, a comprehensive KBS V&V methodology will be developed and documented. Development of highly reliable KBS's cannot be accomplished without effective software engineering methods. Using the results of current in-house research to develop and assess software engineering methods for KBS's as well as assessment of techniques being developed elsewhere, an effective software engineering methodology for space station KBS's will be developed, and modification of the SSF to support these tools and methods will be addressed.

MSR performance enhancements and modifications at St. Lucie Power Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubano, V.F.; Ugelow, A.G.; Menocal, A.G.

1989-01-01

The St. Lucie Power Plant provides an excellent historical prospective on various moisture separator/reheater improvements. Between the two essentially identical units there is a total of 14 years of operating experience with various moisture separator/reheater configurations, with a combination of four different heat transfer surfaces and three moisture removal configurations. Through various modifications and enhancements, the performance and the reliability of the moisture separator/reheaters at the St. Lucie Power Plant and consequently the overall plant performance has been improved. This improvement has taken place over several years and involves changes in both the heat transfer and moisture removal areas. Thismore » paper provides an overview of the history and description of moisture separator/reheater modifications at the St. Lucie Power Plant with the resulting performance improvements.« less

Health-related quality-of-life assessments in diverse population groups in the United States.

PubMed

Stewart, A L; Nápoles-Springer, A

2000-09-01

Effectiveness research needs to represent the increasing diversity of the United States. Health-related quality-of-life (HRQOL) measures are often included as secondary treatment outcomes. Because most HRQOL measures were developed in nonminority, well-educated samples, we must determine whether such measures are conceptually and psychometrically equivalent in diverse subgroups. Without equivalence, overall findings and observed group differences may contain measurement bias. The objectives of this work were to discuss the nature of diversity, importance of ensuring the adequacy of HRQOL measures in diverse groups, methods for assessing comparability of HRQOL measures across groups, and methodological and analytical challenges. Integration of qualitative and quantitative methods is needed to achieve measurement adequacy in diverse groups. Little research explores conceptual equivalence across US subgroups; of the few studies of psychometric comparability, findings are inconsistent. Evidence is needed regarding whether current measures are comparable or need modifications to meet universality assumptions, and we need to determine the best methods for evaluating this. We recommend coordinated efforts to develop guidelines for assessing measurement adequacy across diverse subgroups, allocate resources for measurement studies in diverse populations, improve reporting of and access to measurement results by subgroups, and develop strategies for optimizing the universality of HRQOL measures and resolving inadequacies. We advocate culturally sensitive research that involves cultural subgroups throughout the research process. Because examining the cultural equivalence of HRQOL measures within the United States is somewhat new, we have a unique opportunity to shape the direction of this work through development and dissemination of appropriate methods.

The TOPSAR interferometric radar topographic mapping instrument

NASA Technical Reports Server (NTRS)

Zebker, Howard A.; Madsen, Soren N.; Martin, Jan; Alberti, Giovanni; Vetrella, Sergio; Cucci, Alessandro

1992-01-01

The NASA DC-8 AIRSAR instrument was augmented with a pair of C-band antennas displaced across track to form an interferometer sensitive to topographic variations of the Earth's surface. The antennas were developed by the Italian consortium Co.Ri.S.T.A., under contract to the Italian Space Agency (ASI), while the AIRSAR instrument and modifications to it supporting TOPSAR were sponsored by NASA. A new data processor was developed at JPL for producing the topographic maps, and a second processor was developed at Co.Ri.S.T.A. All the results presented below were processed at JPL. During the 1991 DC-8 flight campaign, data were acquired over several sites in the United States and Europe, and topographic maps were produced from several of these flight lines. Analysis of the results indicate that statistical errors are in the 2-3 m range for flat terrain and in the 4-5 m range for mountainous areas.

Current biotechnological developments in Belgium.

PubMed

Masschelein, C A; Callegari, J P; Laurent, M; Simon, J P; Taeymans, D

1989-01-01

In recent years, actions have been undertaken by the Belgian government to promote process innovation and technical diversification. Research programs are initiated and coordinated by the study committee for biotechnology setup within the Institute for Scientific Research in Industry and Agriculture (IRSIA). As a result of this action, the main areas where biotechnological processes are developed or commercially exploited include plant genetics, protein engineering, hybridoma technology, biopesticides, production by genetic engineering of vaccines and drugs, monoclonal detection of human and animal deseases, process reactors for aerobic and anaerobic wastewater treatment, and genetic modification of yeast and bacteria as a base for biomass and energy. Development research also includes new fermentation technologies principally based on immobilization of microorganisms, reactor design, and optimization of unit operations involved in downstream processing. Food, pharmaceutical, and chemical industries are involved in genetic engineering and biotechnology and each of these sectors is overviewed in this paper.

PINS Testing and Modification for Explosive Identification

DOE Office of Scientific and Technical Information (OSTI.GOV)

E.H. Seabury; A.J. Caffrey

2011-09-01

The INL's Portable Isotopic Neutron Spectroscopy System (PINS)1 non-intrusively identifies the chemical fill of munitions and sealed containers. PINS is used routinely by the U.S. Army, the Defense Threat Reduction Agency, and foreign military units to determine the contents of munitions and other containers suspected to contain explosives, smoke-generating chemicals, and chemical warfare agents such as mustard and nerve gas. The objects assayed with PINS range from softball-sized M139 chemical bomblets to 200 gallon DOT 500X ton containers. INL had previously examined2 the feasibility of using a similar system for the identification of explosives, and based on this proof-of-principle test,more » the development of a dedicated system for the identification of explosives in an improvised nuclear device appears entirely feasible. INL has been tasked by NNSA NA-42 Render Safe Research and Development with the development of such a system.« less

Investigations of Volcanic and Volatile-Driven Processes Northeast of Hellas Basin, Mars

NASA Astrophysics Data System (ADS)

Mest, S. C.; Crown, D. A.; Michalski, J.; Chuang, F. C.; Price Blount, K.; Bleamaster, L. F.

2018-06-01

We are mapping the geologic units and features in three MTM quadrangles northeast of Hellas basin at 1:1M scale. The area displays evidence for volcanism and widespread volatile-related modification of the surface.

40 CFR 60.1030 - Can the Administrator delegate authority to enforce these Federal new source performance...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is Commenced After August 30, 1999 or for Which Modification or...

40 CFR 60.1030 - Can the Administrator delegate authority to enforce these Federal new source performance...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is Commenced After August 30, 1999 or for Which Modification or...

40 CFR 60.1030 - Can the Administrator delegate authority to enforce these Federal new source performance...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is Commenced After August 30, 1999 or for Which Modification or...

Development and validation of an observation tool for the assessment of nursing pain management practices in intensive care unit in a standardized clinical simulation setting.

PubMed

Gosselin, Emilie; Bourgault, Patricia; Lavoie, Stephan; Coleman, Robin-Marie; Méziat-Burdin, Anne

2014-12-01

Pain management in the intensive care unit is often inadequate. There is no tool available to assess nursing pain management practices. The aim of this study was to develop and validate a measuring tool to assess nursing pain management in the intensive care unit during standardized clinical simulation. A literature review was performed to identify relevant components demonstrating optimal pain management in adult intensive care units and to integrate them in an observation tool. This tool was submitted to an expert panel and pretested. It was then used to assess pain management practice during 26 discrete standardized clinical simulation sessions with intensive care nurses. The Nursing Observation Tool for Pain Management (NOTPaM) contains 28 statements grouped into 8 categories, which are grouped into 4 dimensions: subjective assessment, objective assessment, interventions, and reassessment. The tool's internal consistency was calculated at a Cronbach's alpha of 0.436 for the whole tool; the alpha varies from 0.328 to 0.518 for each dimension. To evaluate the inter-rater reliability, intra-class correlation coefficient was used, which was calculated at 0.751 (p < .001) for the whole tool, with variations from 0.619 to 0.920 (p < .01) between dimensions. The expert panel was satisfied with the content and face validity of the tool. The psychometric qualities of the NOTPaM developed in this study are satisfactory. However, the tool could be improved with slight modifications. Nevertheless, it was useful in assessing intensive care nurses' pain management in a standardized clinical simulation. The NOTPaM is the first tool created for this purpose. Copyright © 2014 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.

Plasma surface modification of rigid contact lenses decreases bacterial adhesion.

PubMed

Wang, Yingming; Qian, Xuefeng; Zhang, Xiaofeng; Xia, Wei; Zhong, Lei; Sun, Zhengtai; Xia, Jing

2013-11-01

Contact lens safety is an important topic in clinical studies. Corneal infections usually occur because of the use of bacteria-carrying contact lenses. The current study investigated the impact of plasma surface modification on bacterial adherence to rigid contact lenses made of fluorosilicone acrylate materials. Boston XO and XO2 contact lenses were modified using plasma technology (XO-P and XO2-P groups). Untreated lenses were used as controls. Plasma-treated and control lenses were incubated in solutions containing Staphylococcus aureus or Pseudomonas aeruginosa. MTT colorimetry, colony-forming unit counting method, and scanning electron microscopy were used to measure bacterial adhesion. MTT colorimetry measurements showed that the optical density (OD) values of XO-P and XO2-P were significantly lower than those of XO and XO2, respectively, after incubation with S. aureus (P < 0.01). The OD value of XO-P was also much lower than that of XO after incubation with P. aeruginosa (P < 0.01). Colony-forming unit counting revealed that a significantly lower number of bacterial colonies attached to the XO-P versus XO lenses and to the XO2-P versus XO2 lenses incubated with S. aureus (P < 0.01). Fewer bacterial colonies attached to the XO-P versus XO lenses incubated with P. aeruginosa (P < 0.01). Further, scanning electron microscopy suggested different bacterial adhesion morphology on plasma-treated versus control lenses. Plasma surface modification can significantly decrease bacterial adhesion to fluorosilicone acrylate contact lenses. This study provides important evidence of a unique benefit of plasma technology in contact lens surface modification.

[Genome editing of industrial microorganism].

PubMed

Zhu, Linjiang; Li, Qi

2015-03-01

Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

Heart Rate Variability (HRV) modifications in adult hemiplegic patients after botulinum toxin type A (nt-201) injection.

PubMed

Invernizzi, M; Carda, S; Molinari, C; Stagno, D; Cisari, C; Baricich, A

2015-08-01

The most important adverse effect of BoNT-A is the systemic diffusion of the toxin. There is some evidence that the administration of high doses can increase the risk of systemic diffusion and the development of clinically evident adverse effects, however an international consensus does not exist about its maximum dose. The aim of this study was to evaluate changes in autonomic heart drive induced by high doses (higher than 600 units) of incobotulinumtoxinA injection in spastic stroke patients. Moreover, the treatment safety by monitoring adverse events occurrence was assessed. Case control study. Eleven stroke survivors with spastic hemiplegia. Patients were treated with intramuscular focal injections of IncobotulinumtoxinA (NT 201; Xeomin®, Merz Pharmaceuticals GmbH, Frankfurt, Germany). Doses were below 12 units/Kg. Each patient underwent an ECG recording before injection and 10 days after treatment. Linear and non-linear Heart Rate variability (HRV) measures were derived from ECGs with a dedicated software. None of the variable considered showed statistically significant changes after BoNT-A injection. The use of incobotulinumtoxinA in adult patients at doses up to 12 units/kg seems to be safe regarding autonomic heart drive. The use of IncobotulinumtoxinA up to 600 units could be a safe therapeutic option in spastic hemiplegic stroke survivors.

U.S. Department of Energy Vehicle Technologies Program: Battery Test Manual For Plug-In Hybrid Electric Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christophersen, Jon P.

2014-09-01

This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Office. It is based on technical targets for commercial viability established for energy storage development projects aimed at meeting system level DOE goals for Plug-in Hybrid Electric Vehicles (PHEV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for PHEV’s. However, it does share some methods described in the previously published battery test manual for power-assist hybrid electric vehicles. Due to the complexity of somemore » of the procedures and supporting analysis, future revisions including some modifications and clarifications of these procedures are expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices. The DOE-United States Advanced Battery Consortium (USABC), Technical Advisory Committee (TAC) supported the development of the manual. Technical Team points of contact responsible for its development and revision are Renata M. Arsenault of Ford Motor Company and Jon P. Christophersen of the Idaho National Laboratory. The development of this manual was funded by the Unites States Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Technical direction from DOE was provided by David Howell, Energy Storage R&D Manager and Hybrid Electric Systems Team Leader. Comments and questions regarding the manual should be directed to Jon P. Christophersen at the Idaho National Laboratory (jon.christophersen@inl.gov).« less

Determination of Optimum Cross-section for Oran Highway Revetment

NASA Astrophysics Data System (ADS)

Sogut, E.; Velioglu, D.; Guler, I.

2016-12-01

Revetments are shore parallel, sloping coastal structures which are built to provide protection from the negative effects of the sea. The revetment mentioned in this study is located in the City of Oran, Algeria and is currently under construction. This study investigates the determination of the optimum revetment cross section for Oran highway, considering both the hydraulic stability of the revetment and economy. The existence of cliffs in the region and the settlement of the City of Oran created a necessity to re-align Oran highway; therefore, it was shifted towards the Gulf of Oran. Approximately 1 km of the highway is to be constructed on the Mediterranean Sea due to the new alignment. In order to protect the sea side of the road from the adverse effects of the sea, a revetment was designed. The proposed cross section had an armour layer composed of 23 tons of antifer units and regular placement of armour units was recommended. In order to check the hydraulic stability of the proposed section, physical model tests were performed in the laboratory of LEM (Laboratoire d'Etudes Maritimes) in Algeria, using the pre-determined design wave conditions. The physical model tests revealed that the trunk of the revetment was totaly damaged. Accordingly, the proposed section was found insufficient and certain modifications were required. The first modification was made in the arrangement of armour units, changing them from regular to irregular. After testing the new cross section, it was observed that the revetment was vulnerable to breaking wave attack due to the toe geometry and thus the toe of the revetment had to be re-shaped. Therefore, the second option was to reduce the toe elevation. It was observed that even though the revetment trunk was safe, the damage in the toe was not in acceptable limits. The new cross section was found insufficient and as the final option, the weight of the antifer units used in the armour layer was increased, the toe length of the structure was increased and the size of the armour units in the toe was decreased. After the modifications, the new section was tested physically and it was selected as the most optimum option.

ITE Trip Generation Modification Factors for Louisiana : Research Project Capsule

DOT National Transportation Integrated Search

2017-12-01

Using data from studies conducted in the United States over the last 50-60 years, the Institute of Transportation Engineers (ITE) has published trip generation rates for different land uses. Over time, observations from new studies have been incorpor...

Lightweight concrete modification factor for shear friction.

DOT National Transportation Integrated Search

2013-10-01

This report describes the results of a study initiated to examine the influence of concrete unit weight on the direct shear transfer across an interface of concretes cast at different times. This type of interface is common with structural precast co...

Flexible shielding system for radiation protection

NASA Technical Reports Server (NTRS)

Babin, A.

1972-01-01

Modular construction of low cost flexible radiation shielding panels consists of water filled steels cans, zinc bromide windows, turntable unit, master-slave manipulators, and interlocking lead bricks. Easy modifications of shielding wall thicknesses are obtained by rearranging overall geometry of portable components.

Space Shuttle 750 psi Helium Regulator Application on Mars Science Laboratory Propulsion

NASA Technical Reports Server (NTRS)

Mizukami, Masashi; Yankura, George; Rust, Thomas; Anderson, John R.; Dien, Anthony; Garda, Hoshang; Bezer, Mary Ann; Johnson, David; Arndt, Scott

2009-01-01

The Mars Science Laboratory (MSL) is NASA's next major mission to Mars, to be launched in September 2009. It is a nuclear powered rover designed for a long duration mission, with an extensive suite of science instruments. The descent and landing uses a unique 'skycrane' concept, where a rocket-powered descent stage decelerates the vehicle, hovers over the ground, lowers the rover to the ground on a bridle, then flies a safe distance away for disposal. This descent stage uses a regulated hydrazine propulsion system. Performance requirements for the pressure regulator were very demanding, with a wide range of flow rates and tight regulated pressure band. These indicated that a piloted regulator would be needed, which are notoriously complex, and time available for development was short. Coincidentally, it was found that the helium regulator used in the Space Shuttle Orbiter main propulsion system came very close to meeting MSL requirements. However, the type was out of production, and fabricating new units would incur long lead times and technical risk. Therefore, the Space Shuttle program graciously furnished three units for use by MSL. Minor modifications were made, and the units were carefully tuned to MSL requirements. Some of the personnel involved had built and tested the original shuttle units. Delta qualification for MSL application was successfully conducted on one of the units. A pyrovalve slam start and shock test was conducted. Dynamic performance analyses for the new application were conducted, using sophisticated tools developed for Shuttle. Because the MSL regulator is a refurbished Shuttle flight regulator, it will be the only part of MSL which has physically already been in space.

Effect of age and gender on the number of motor units in healthy subjects estimated by the multipoint incremental MUNE method.

PubMed

Gawel, Malgorzata; Kostera-Pruszczyk, Anna

2014-06-01

Motor unit number estimation (MUNE) is a tool for estimating the number of motor units. The aim was to evaluate the multipoint incremental MUNE method in a healthy population, to analyze whether aging, gender, and the dominant hand side influence the motor unit number, and to assess reproducibility of MUNE with the Shefner modification. We studied 60 volunteers (mean age, 47 ± 17.7 years) in four groups aged 18 to 30, 31 to 45, 46 to 60, and above 60 years. Motor unit number estimation was calculated in the abductor pollicis brevis (APB) and the abductor digiti minimi (ADM) by dividing the single motor unit action potential amplitude into the maximal compound motor action potential amplitude. Test-retest variability was 7%. The mean value of MUNE for APB was 133.2 ± 43 and for ADM was 157.1 ± 39.4. Significant differences in MUNE results were found between groups aged 18 to 30 and 60 years or older and between groups aged 31 to 45 and 60 years or older. Motor unit number estimation results correlated negatively with the age of subjects for both APB and ADM. Single motor unit action potential, reflecting the size of motor unit, increased with the age of subjects only in APB. Compound motor action potential amplitude correlated negatively with the age of subjects in APB and ADM. Significant correlations were seen between MUNE in APB or ADM and compound motor action potential amplitude in these muscles and the age of female subjects. A similar relationship was not found in males. Multipoint incremental MUNE method with the Shefner modification is a noninvasive, easy to perform method with high reproducibility. The loss of motor neurons because of aging could be confirmed by our MUNE study and seems to be more pronounced in females.

Eighth Annual Report of the United States Geological Survey to the Secretary of the Interior, 1886-1887: Part 1

USGS Publications Warehouse

Powell, J.W.

1889-01-01

The Geological Survey was organized, with Mr. Clarence King as Director, in March, 1879. In March, 1881, Mr. King resigned and the present Director was appointed. From its organization to the present time the Survey has steadily grown as Congress has enlarged its functions and increased its appropriations. During this time the scientific organization has gradually developed to the condition set forth in the last annual report. It seems advisable now to describe fully the business organization and methods of the Survey, which has heretofore been done only in part. Under the act of July 7, 1884, a joint commission was created to consider the organization of certain scientific bureaus. In the volume of testimony prepared by that commission the business operations of the Geological Survey were in part set forth; but this partial presentation was unsystematic, the facts recorded being elicited in irregular order by interrogatories arising in the course of a long investigation. It is designed here to make a more thorough exposition oi the subject. The business system of the Geological Survey is subordinate to the scientific organization and its character is dependent thereon. The development of the divisions of the Survey whose function is the transaction of business has therefore followed the development of the purely scientific divisions, and overy modification of plan for the scientific work may carry with it some modification of the business organization.

13 CFR 304.3 - District modification and termination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... termination. 304.3 Section 304.3 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.3 District modification and termination. (a... for economic development. (b) Termination. EDA may, upon sixty (60) days prior written notice to the...

Adjoint sensitivity analysis of chaotic dynamical systems with non-intrusive least squares shadowing

NASA Astrophysics Data System (ADS)

Blonigan, Patrick J.

2017-11-01

This paper presents a discrete adjoint version of the recently developed non-intrusive least squares shadowing (NILSS) algorithm, which circumvents the instability that conventional adjoint methods encounter for chaotic systems. The NILSS approach involves solving a smaller minimization problem than other shadowing approaches and can be implemented with only minor modifications to preexisting tangent and adjoint solvers. Adjoint NILSS is demonstrated on a small chaotic ODE, a one-dimensional scalar PDE, and a direct numerical simulation (DNS) of the minimal flow unit, a turbulent channel flow on a small spatial domain. This is the first application of an adjoint shadowing-based algorithm to a three-dimensional turbulent flow.

[Oxygen and the superoxide anion. Modulation of NADPH oxidase?].

PubMed

Delbosc, S; Cristol, J P; Descomps, B; Chénard, J; Sirois, P

2001-01-01

Oxidative stress which results from an imbalance between oxidant production and antioxidant defense mechanisms can promote modifications of lipids, proteins and nucleic acids. This review focuses on the different pathways leading to Reactive Oxygen Species (ROS) production in particular on NADPH oxidase activation. This enzyme is localized in numerous cells including phagocytes and vascular cells and composed of membrane and cytosolic sub-units. The activation of the NADPH oxidase is largely involved in inflammation associated diseases such as asthma, Systemic Inflammatory Response Syndrome and aging associated diseases such as atherosclerosis and neurodeneratives diseases. The modulation of NADPH oxidase could be a way to limit or prevent the development of these diseases.

Block-copolymer-controlled growth of CaCO3 microrings.

PubMed

Gao, Yun-Xiang; Yu, Shu-Hong; Cong, Huaiping; Jiang, Jun; Xu, An-Wu; Dong, W F; Cölfen, Helmut

2006-04-06

A novel way for directed solution growth of hollow superstructures of CaCO3 has been successfully developed on the basis of controlled self-assembly and polymer concentration gradients using a double-hydrophilic block copolymer with a hydrophobic modification as a directing agent. A formation mechanism of such rings is proposed on the basis of the formation of CaCO3 nanoparticles in unstructured block copolymer assemblies with subsequent aggregation of these primary nanoparticles. This leads to the formation of a polymer concentration gradient from the inside to the outside of the particle. As the polymer contains multiple chelating units, this leads to a selective dissolution of the center of the particle.

Performance evaluation and calibration of a modular multiband radiometer for remote sensing field research

NASA Technical Reports Server (NTRS)

Robinson, B. F.; Buckley, R. E.; Burgess, J. A. (Principal Investigator)

1982-01-01

A multiband radiometer suitable for operation from helicopter, small plane, truck, or tripod platforms was developed. The standard unit is equipped with the seven thematic mapper spectral bands with an added band from 1.5 to 1.30 microns; however, up to eight user specified bands from 0.4 to 15 microns may be installed under clean field conditions. Results of prototype tests of the spectral responsivity of the detectors, the transmittance of the optical filters as a function of wavelength, the fields of view, and the system linearity, temperature stability, noise performance, and dynamic range were evaluated. Minor modifications were made to the instrument and the results of final testing are reported.

Low cost solar array project production process and equipment task: A Module Experimental Process System Development Unit (MEPSDU)

NASA Technical Reports Server (NTRS)

1981-01-01

Several major modifications were made to the design presented at the PDR. The frame was deleted in favor of a "frameless" design which will provide a substantially improved cell packing factor. Potential shaded cell damage resulting from operation into a short circuit can be eliminated by a change in the cell series/parallel electrical interconnect configuration. The baseline process sequence defined for the MEPSON was refined and equipment design and specification work was completed. SAMICS cost analysis work accelerated, format A's were prepared and computer simulations completed. Design work on the automated cell interconnect station was focused on bond technique selection experiments.

Modular evolution of the Cetacean vertebral column.

PubMed

Buchholtz, Emily A

2007-01-01

Modular theory predicts that hierarchical developmental processes generate hierarchical phenotypic units that are capable of independent modification. The vertebral column is an overtly modular structure, and its rapid phenotypic transformation in cetacean evolution provides a case study for modularity. Terrestrial mammals have five morphologically discrete vertebral series that are now known to be coincident with Hox gene expression patterns. Here, I present the hypothesis that in living Carnivora and Artiodactyla, and by inference in the terrestrial ancestors of whales, the series are themselves components of larger precaudal and caudal modular units. Column morphology in a series of fossil and living whales is used to predict the type and sequence of developmental changes responsible for modification of that ancestral pattern. Developmental innovations inferred include independent meristic additions to the precaudal column in basal archaeocetes and basilosaurids, stepwise homeotic reduction of the sacral series in protocetids, and dissociation of the caudal series into anterior tail and fluke subunits in basilosaurids. The most dramatic change was the novel association of lumbar and anterior caudal vertebrae in a module that crosses the precaudal/caudal boundary. This large unit is defined by shared patterns of vertebral morphology, count, and size in all living whales (Neoceti).

The Role of DNA Methylation in the Development and Progression of Lung Adenocarcinoma

PubMed Central

Kerr, Keith M.; Galler, Janice S.; Hagen, Jeffrey A.; Laird, Peter W.; Laird-Offringa, Ite A.

2007-01-01

Lung cancer, caused by smoking in ∼87% of cases, is the leading cause of cancer death in the United States and Western Europe. Adenocarcinoma is now the most common type of lung cancer in men and women in the United States, and the histological subtype most frequently seen in never-smokers and former smokers. The increasing frequency of adenocarcinoma, which occurs more peripherally in the lung, is thought to be at least partially related to modifications in cigarette manufacturing that have led to a change in the depth of smoke inhalation. The rising incidence of lung adenocarcinoma and its lethal nature underline the importance of understanding the development and progression of this disease. Alterations in DNA methylation are recognized as key epigenetic changes in cancer, contributing to chromosomal instability through global hypomethylation, and aberrant gene expression through alterations in the methylation levels at promoter CpG islands. The identification of sequential changes in DNA methylation during progression and metastasis of lung adenocarcinoma, and the elucidation of their interplay with genetic changes, will broaden our molecular understanding of this disease, providing insights that may be applicable to the development of targeted drugs, as well as powerful markers for early detection and patient classification. PMID:17325423

Formal verification of a set of memory management units

NASA Technical Reports Server (NTRS)

Schubert, E. Thomas; Levitt, K.; Cohen, Gerald C.

1992-01-01

This document describes the verification of a set of memory management units (MMU). The verification effort demonstrates the use of hierarchical decomposition and abstract theories. The MMUs can be organized into a complexity hierarchy. Each new level in the hierarchy adds a few significant features or modifications to the lower level MMU. The units described include: (1) a page check translation look-aside module (TLM); (2) a page check TLM with supervisor line; (3) a base bounds MMU; (4) a virtual address translation MMU; and (5) a virtual address translation MMU with memory resident segment table.

Frequency doubling crystals

DOEpatents

Wang, Francis; Velsko, Stephan P.

1989-01-01

A systematic approach to the production of frequency conversion crystals is described in which a chiral molecule has attached to it a "harmonic generating unit" which contributes to the noncentrosymmetry of the molecule. Certain preferred embodiments of such harmonic generating units include carboxylate, guanadyly and imidazolyl units. Certain preferred crystals include L-arginine fluoride, deuterated L-arginine fluoride, L-arginine chloride monohydrate, L-arginine acetate, dithallium tartrate, ammonium N-acetyl valine, N-acetyl tyrosine and N-acetyl hydroxyproline. Chemical modifications of the chiral molecule, such as deuteration, halogenation and controlled counterion substitution are available to adapt the dispersive properties of a crystal in a particular wavelength region.

High voltage and current, gate assisted, turn-off thyristor development

NASA Technical Reports Server (NTRS)

Nowalk, T. P.; Brewster, J. B.; Kao, Y. C.

1972-01-01

An improved high speed power switch with unique turn-off capability was developed. This gate assisted turn-off thyristor (GATT) was rated 1000 volts and 100 amperes with turn-off times of 2 microseconds. Fifty units were delivered for evaluation. In addition, test circuits designed to relate to the series inverter application were built and demonstrated. In the course of this work it was determined that the basic device design is adequate to meet the static characteristics and dynamic turn-off specification. It was further determined that the turn-on specification is critically dependent on the gate drive circuit due to the distributive nature of the cathode-gate geometry. Future work should emphasize design modifications which reduce the gate current required for fast turn-on, thereby opening the way to higher power (current) devices.

Potential for reduction of odorous compounds in swine manure through diet modification.

PubMed

Sutton, A L; Kephart, K B; Verstegen, M W; Canh, T T; Hobbs, P J

1999-02-01

Recent public concern about air pollution from pork production units has prompted more research to develop methods to reduce and control odors. Masking agents, enzymes and bacterial preparations, feed additives, chemicals, oxidation processes, air scrubbers, biofilters, and new ventilation systems have been studied. Research relating the effects of the swine diet on manure odors has been scarce. Introducing feed additives to bind ammonia, change digesta pH, affect specific enzyme activity, and mask odors has been either costly or not consistently successful. Recent research emphasis has focused on manipulating the diet 1) to increase the nutrient utilization of the diet to reduce excretion products, 2) to enhance microbial metabolism in the lower digestive tract to reduce excretion of odor-causing compounds, and 3) to change the physical characteristics of urine and feces to reduce odor emissions. Primary odor-causing compounds evolve from excess degradable proteins and lack of specific fermentable carbohydrates during microbial fermentation. Reductions in ammonia emissions by 28 to 79% through diet modifications have been reported. Limited research on reduction of other odorous volatile organic compounds through diet modifications is promising. Use of synthetic amino acids with reduced intact protein levels in diets significantly reduces nitrogen excretions and odor production. Addition of nonstarch polysaccharides and specific oligosaccharides further alters the pathway of nitrogen excretion and reduces odor emission. Continued nutritional and microbial research to incorporate protein degradation products, especially sulfur-containing organics, with fermentable carbohydrates in the lower gastrointestinal tract of pigs will further control odors from manure.

Evaluating environmental impact caused by industrial activities - Implementation of the WTP-WTA approach

NASA Astrophysics Data System (ADS)

Kopsidas, Odysseas; Batzias, Fragiskos

2012-12-01

In this work, a methodological framework under the form of an algorithmic procedure, including 28 activity stages and 6 decision nodes, has been developed for evaluating environmental impact caused by industrial activities. The main part of this procedure is a modification of the Contingent Valuation Method (CVM), which is heavily relied on survey-based estimation of WTP-WTA (willingness to pay/accept, respectively). The survey may take place either under a strictly controlled environment or in situ and as-is ('laboratory conditions' or 'field conditions', respectively, in the terminology of experimental economics). Implementation of this methodology is presented, referring to three cases of industrial pollution (in three different sites) caused by (i) a cement producing units, (ii) an oil refinery complex, and (iii) an industrialized small city with an intensively polluted port, where several industrial units co-exist, all of them located in the vicinity of Athens, Greece. The results are interpreted/discussed and conclusions are drawn.

Bad data detection in two stage estimation using phasor measurements

NASA Astrophysics Data System (ADS)

Tarali, Aditya

The ability of the Phasor Measurement Unit (PMU) to directly measure the system state, has led to steady increase in the use of PMU in the past decade. However, in spite of its high accuracy and the ability to measure the states directly, they cannot completely replace the conventional measurement units due to high cost. Hence it is necessary for the modern estimators to use both conventional and phasor measurements together. This thesis presents an alternative method to incorporate the new PMU measurements into the existing state estimator in a systematic manner such that no major modification is necessary to the existing algorithm. It is also shown that if PMUs are placed appropriately, the phasor measurements can be used to detect and identify the bad data associated with critical measurements by using this model, which cannot be detected by conventional state estimation algorithm. The developed model is tested on IEEE 14, IEEE 30 and IEEE 118 bus under various conditions.

An Advanced Photovoltaic Array Regulator Module

NASA Technical Reports Server (NTRS)

Button, Robert M.

1996-01-01

Current trends in satellite design are focused on developing small, reliable, and inexpensive spacecraft. To that end, a modular power management and distribution system is proposed which will help transition the aerospace industry towards an assembly line approach to building spacecraft. The modular system is based on an innovative DC voltage boost converter called the Series Connected Boost Unit (SCBU). The SCBU uses any isolating DC-DC converter and adds a unique series connection. This simple modification provides the SCBU topology with many advantages over existing boost converters. Efficiencies of 94-98%, power densities above 1,000 W/kg, and inherent fault tolerance are just a few of the characteristics presented. Limitations of the SCBU technology are presented, and it is shown that the SCBU makes an ideal photovoltaic an-ay regulator. A set of photovoltaic power system requirements are presented that can be applied to almost any low Earth orbit satellite. Finally, a modular design based on the series connected boost unit is outlined and functional descriptions of the components are given.

Electrophoretic mobility shift scanning using an automated infrared DNA sequencer.

PubMed

Sano, M; Ohyama, A; Takase, K; Yamamoto, M; Machida, M

2001-11-01

Electrophoretic mobility shift assay (EMSA) is widely used in the study of sequence-specific DNA-binding proteins, including transcription factors and mismatch binding proteins. We have established a non-radioisotope-based protocol for EMSA that features an automated DNA sequencer with an infrared fluorescent dye (IRDye) detection unit. Our modification of the elec- trophoresis unit, which includes cooling the gel plates with a reduced well-to-read length, has made it possible to detect shifted bands within 1 h. Further, we have developed a rapid ligation-based method for generating IRDye-labeled probes with an approximately 60% cost reduction. This method has the advantages of real-time scanning, stability of labeled probes, and better safety associated with nonradioactive methods of detection. Analysis of a promoter from an industrially important filamentous fungus, Aspergillus oryzae, in a prototype experiment revealed that the method we describe has potential for use in systematic scanning and identification of the functionally important elements to which cellular factors bind in a sequence-specific manner.

Turbomachinery group for cold energy concept application

NASA Astrophysics Data System (ADS)

Alavi, S.; Arpi, A.; Ascani, M.; Cerri, G.; Chennaoui, L.; Manni, A.

2017-08-01

The paper discusses a special attempt to improve COP and compressor capacity. Theoretical and experimental results are presented, and they show a very positive trend. Compressor and Expander Group impellers are selected among the Car Engine Turbocharger Units. Modifications are proposed to achieve the best performance, taking the peculiar characteristics of the refrigerant into consideration. Tests have confirmed the positive saving trend, which can reach up to 22%-24% for an optimized bleed vapour generator and turbomachinery-based booster unit.

Functional Rehabilitation With a Foot Plate Modification for Circular External Fixation

DTIC Science & Technology

2013-04-05

5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) United States Army Institute of...Surgical Research, JBSA Fort Sam Houston, TX 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR...patient was able to perform . Results: Eleven patients were identified. All patients were treated by the same physical therapist. All 11 patients were able

Antifreeze (glyco)protein mimetic behavior of poly(vinyl alcohol): detailed structure ice recrystallization inhibition activity study.

PubMed

Congdon, Thomas; Notman, Rebecca; Gibson, Matthew I

2013-05-13

This manuscript reports a detailed study on the ability of poly(vinyl alcohol) to act as a biomimetic surrogate for antifreeze(glyco)proteins, with a focus on the specific property of ice-recrystallization inhibition (IRI). Despite over 40 years of study, the underlying mechanisms that govern the action of biological antifreezes are still poorly understood, which is in part due to their limited availability and challenging synthesis. Poly(vinyl alcohol) (PVA) has been shown to display remarkable ice recrystallization inhibition activity despite its major structural differences to native antifreeze proteins. Here, controlled radical polymerization is used to synthesize well-defined PVA, which has enabled us to obtain the first quantitative structure-activity relationships, to probe the role of molecular weight and comonomers on IRI activity. Crucially, it was found that IRI activity is "switched on" when the polymer chain length increases from 10 and 20 repeat units. Substitution of the polymer side chains with hydrophilic or hydrophobic units was found to diminish activity. Hydrophobic modifications to the backbone were slightly more tolerated than side chain modifications, which implies an unbroken sequence of hydroxyl units is necessary for activity. These results highlight that, although hydrophobic domains are key components of IRI activity, the random inclusion of addition hydrophobic units does not guarantee an increase in activity and that the actual polymer conformation is important.

Measurement Invariance of the Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) between the United States of America, India and the United Kingdom.

PubMed

Pontes, Halley M; Stavropoulos, Vasileios; Griffiths, Mark D

2017-11-01

The Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) has been extensively used worldwide to assess Internet Gaming Disorder (IGD) behaviors. Therefore, investigating cultural limitations and implications in its applicability is necessary. The cross-cultural feasibility of a test can be psychometrically evaluated with measurement invariance analyses. Thus, the present study used Multigroup Confirmatory Factor Analysis (MGCFA) to examine the IGDS9-SF measurement invariance across gamers from the United States of America (USA), India, and the United Kingdom (UK). A total of 1013 gamers from the USA (n = 405), India (n = 336), and the UK (n = 272) were recruited. Although the one-factor structure of the IGD construct was supported, cross-country variations were demonstrated considering the way that this was reflected on items assessing preoccupation/salience, tolerance, deception, gaming escapism/mood modification, as well as daily activities' impairment related to gaming. Furthermore, the same scores on items assessing withdrawal symptoms, tolerance, lack of control over gaming engagement, escapism/mood modification and daily activities impairment associated to gaming, have been found to reflect various levels of IGD severity across the three groups. The implications of these results are further discussed in the context of existing evidence regarding the assessment of IGD. Copyright © 2017 Elsevier B.V. All rights reserved.

United States Postal Service's CSRS Obligation Modification Act of 2010

THOMAS, 111th Congress

Rep. Lynch, Stephen F. [D-MA-9

2010-07-15

House - 07/21/2010 Forwarded by Subcommittee to Full Committee in the Nature of a Substitute by the Yeas and Nays: 8 - 1 . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

22 CFR 144.110 - Self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF STATE § 144.110 Self... modifications. (b) The agency shall provide an opportunity to interested persons, including handicapped persons...

22 CFR 144.110 - Self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF STATE § 144.110 Self... modifications. (b) The agency shall provide an opportunity to interested persons, including handicapped persons...

22 CFR 144.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF STATE § 144.110 Self... modifications. (b) The agency shall provide an opportunity to interested persons, including handicapped persons...

22 CFR 144.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF STATE § 144.110 Self... modifications. (b) The agency shall provide an opportunity to interested persons, including handicapped persons...

48 CFR 52.215-11 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... affirmative action to bring the character of the data to the attention of the Contracting Officer. (iii) The... price reduction, the Contractor shall be liable to and shall pay the United States at the time such...

48 CFR 52.215-11 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... affirmative action to bring the character of the data to the attention of the Contracting Officer. (iii) The... price reduction, the Contractor shall be liable to and shall pay the United States at the time such...

48 CFR 52.215-11 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... affirmative action to bring the character of the data to the attention of the Contracting Officer. (iii) The... price reduction, the Contractor shall be liable to and shall pay the United States at the time such...

Systems design study of the Pioneer Venus spacecraft. Appendices to volume 1, sections 8-11 (part 3 of 3). [power subsystem/cost tradeoffs for Venus probe

NASA Technical Reports Server (NTRS)

1973-01-01

Power subsystem cost/weight tradeoffs are discussed for the Venus probe spacecraft. The cost estimations of power subsystem units were based upon DSCS-2, DSP, and Pioneer 10 and 11 hardware design and development and manufacturing experience. Parts count and degree of modification of existing hardware were factored into the estimate of manufacturing and design and development costs. Cost data includes sufficient quantities of units to equip probe bus and orbiter versions. It was based on the orbiter complement of equipment, but the savings in fewer slices for the probe bus balance the cost of the different probe bus battery. The preferred systems for the Thor/Delta and for the Atlas/Centaur are discussed. The weights of the candidate designs were based upon slice or tray weights for functionally equivalent circuitry measured on existing hardware such as Pioneers 10 and 11, Intelsat 3, DSCS-2, or DSP programs. Battery weights were based on measured cell weight data adjusted for case weight or off-the-shelf battery weights. The solar array weight estimate was based upon recent hardware experience on DSCS-2 and DSP arrays.

Rapid Crop Cover Mapping for the Conterminous United States.

PubMed

Dahal, Devendra; Wylie, Bruce; Howard, Danny

2018-06-05

Timely crop cover maps with sufficient resolution are important components to various environmental planning and research applications. Through the modification and use of a previously developed crop classification model (CCM), which was originally developed to generate historical annual crop cover maps, we hypothesized that such crop cover maps could be generated rapidly during the growing season. Through a process of incrementally removing weekly and monthly independent variables from the CCM and implementing a 'two model mapping' approach, we found it viable to generate conterminous United States-wide rapid crop cover maps at a resolution of 250 m for the current year by the month of September. In this approach, we divided the CCM model into one 'crop type model' to handle the classification of nine specific crops and a second, binary model to classify the presence or absence of 'other' crops. Under the two model mapping approach, the training errors were 0.8% and 1.5% for the crop type and binary model, respectively, while test errors were 5.5% and 6.4%, respectively. With spatial mapping accuracies for annual maps reaching upwards of 70%, this approach demonstrated a strong potential for generating rapid crop cover maps by the 1 st of September.

Liquid phase methanol LaPorte process development unit: Modification, operation, and support studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The objectives of the present work can be divided into three parts. The first objective was to develop a best-fit model for the older methanol synthesis catalyst (BASF S3-85) data base. At the time that this work commenced (June 1989), the BASF S3-85 data base contained many rate measurements accumulated over a few years. The newer catalyst (BASF S3-86) data base, at that time, contained only a few observations and did not include a broad range of conditions. Thus, a second objective of this work was to expand the BASF S3-86 data base to include more rate observations over amore » broader range of conditions. Finally, after expansion of the BASF S3-86 data base, the third objective was to develop a rate expression to describe this data base. This would include the application of rate expressions developed for the BASF S3-85 catalyst, as well as new models. (VC)« less

Obesity pharmacotherapy: What is next?

PubMed Central

Colon-Gonzalez, Francheska; Kim, Gilbert W.; Lin, Jieru E.; Valentino, Michael A.; Waldman, Scott A.

2014-01-01

The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modifications are the most straightforward way to control weight, a large portion of the population may not be able to rely on this modality alone. Thus, the development of anti-obesity therapeutics represents a major unmet medical need. Historically, anti-obesity pharmacotherapies have been unsafe and minimally efficacious. A better understanding of the biology of appetite and metabolism provides an opportunity to develop drugs that may offer safer and more effective alternatives for weight management. This review discusses drugs that are currently on the market and in development as anti-obesity therapeutics based on their target and mechanism of action. It should serve as a roadmap to establish expectations for the near future for anti-obesity drug development. PMID:23103610

DOE Office of Scientific and Technical Information (OSTI.GOV)

Evans, G.C.

The Environmental Restoration Disposal Facility (ERDF) is to accept both CERCLA (EPA-regulated) and RCRA (Ecology-regulated) remediation waste. The ERDF is considered part of the overall remediation strategy on the Hanford Site, and as such, determination of ERDF viability has followed both RCRA and CERCLA decision making processes. Typically, determination of the viability of a unit, such as the ERDF, would occur as part of record of decision (ROD) or permit modification for each remediation site before construction of the ERDF. However, because construction of the ERDF may take a significant amount of time, it is necessary to begin design andmore » construction of the ERDF before final RODs/permit modifications for the remediation sites. This will allow movement of waste to occur quickly once the final remediation strategy for the RCRA and CERCLA past-practice units is determined. Construction of the ERDF is a unique situation relative to Hanford Facility cleanup, requiring a Hanford Facility specific process be developed for implementing the ERDF that would satisfy both RCRA and CERCLA requirements. While the ERDF will play a significant role in the remediation process, initiation of the ERDF does not preclude the evaluation of remedial alternatives at each remediation site. To facilitate this, the January 1994 amendment to the Tri-Party Agreement recognizes the necessity for the ERDF, and the Tri-Party Agreement states: ``Ecology, EPA, and DOE agree to proceed with the steps necessary to design, approve, construct, and operate such a ... facility.`` The Tri-Party Agreement requires the DOE-RL to prepare a comprehensive ``package`` for the EPA and Ecology to consider in evaluating the ERDF. The package is to address the criteria listed in 40 CFR 264.552(c) for corrective action management unit (CAMU) designation and a CERCLA ROD. This CAMU application is submitted as part of the Tri-Party Agreement-required information package.« less

Shuttle Upgrade Using 5-Segment Booster (FSB)

NASA Technical Reports Server (NTRS)

Sauvageau, Donald R.; Huppi, Hal D.; McCool, A. A. (Technical Monitor)

2000-01-01

In support of NASA's continuing effort to improve the over-all safety and reliability of the Shuttle system- a 5-segment booster (FSB) has been identified as an approach to satisfy that overall objective. To assess the feasibility of a 5-segment booster approach, NASA issued a feasibility study contract to evaluate the potential of a 5-segment booster to improve the overall capability of the Shuttle system, especially evaluating the potential to increase the system reliability and safety. In order to effectively evaluate the feasibility of the 5-segment concept, a four-member contractor team was established under the direction of NASA Marshall Space Flight Center (MSFC). MSFC provided the overall program oversight and integration as well as program contractual management. The contractor team consisted of Thiokol, Boeing North American Huntington Beach (BNA), Lockheed Martin Michoud Space Systems (LMMSS) and United Space Alliance (USA) and their subcontractor bd Systems (Control Dynamics Division, Huntsville, AL). United Space Alliance included the former members of United Space Booster Incorporated (USBI) who managed the booster element portion of the current Shuttle solid rocket boosters. Thiokol was responsible for the overall integration and coordination of the contractor team across all of the booster elements. They were also responsible for all of the motor modification evaluations. Boeing North American (BNA) was responsible for all systems integration analyses, generation of loads and environments. and performance and abort mode capabilities. Lockheed Martin Michoud Space Systems (LMMSS) was responsible for evaluating the impacts of any changes to the booster on the external tank (ET), and evaluating any design changes on the external tank necessary to accommodate the FSB. USA. including the former USBI contingent. was responsible for evaluating any modifications to facilities at the launch site as well as any booster component design modifications.

Strategies for the acquisition of transcriptional and epigenetic information in single cells.

PubMed

Li, Guang; Dzilic, Elda; Flores, Nick; Shieh, Alice; Wu, Sean M

2017-03-01

As the basic unit of living organisms, each single cell has unique molecular signatures and functions. Our ability to uncover the transcriptional and epigenetic signature of single cells has been hampered by the lack of tools to explore this area of research. The advent of microfluidic single cell technology along with single cell genome-wide DNA amplification methods had greatly improved our understanding of the expression variation in single cells. Transcriptional expression profile by multiplex qPCR or genome-wide RNA sequencing has enabled us to examine genes expression in single cells in different tissues. With the new tools, the identification of new cellular heterogeneity, novel marker genes, unique subpopulations, and spatial locations of each single cell can be acquired successfully. Epigenetic modifications for each single cell can also be obtained via similar methods. Based on single cell genome sequencing, single cell epigenetic information including histone modifications, DNA methylation, and chromatin accessibility have been explored and provided valuable insights regarding gene regulation and disease prognosis. In this article, we review the development of strategies to obtain single cell transcriptional and epigenetic data. Furthermore, we discuss ways in which single cell studies may help to provide greater understanding of the mechanisms of basic cardiovascular biology that will eventually lead to improvement in our ability to diagnose disease and develop new therapies.

Hospitalization Drug Regimen Changes in Geriatric Patients and Adherence to Modifications by General Practitioners in Primary Care.

PubMed

Rouch, L; Farbos, F; Cool, C; McCambridge, C; Hein, C; Elmalem, S; Rolland, Y; Vellas, B; Cestac, P

2018-01-01

To evaluate the overall rate of adherence by general practitioners (GPs) to treatment modifications suggested at discharge from hospital and to assess the way communication between secondary and primary care could be improved. Observational prospective cohort study. Patients hospitalized from the emergency department to the acute geriatric care unit of a university hospital. 206 subjects with a mean age of 85 years. Changes in drug regimen undertaken during hospitalization were collected with the associated justifications. Adherence at one month by GPs to treatment modifications was assessed as well as modifications implemented in primary care with their rationale in case of non-adherence. Community pharmacists' and GPs' opinions about quality of communication and information transfer at hospital-general practice interface were investigated. 5.5 ± 2.8 drug regimen changes were done per patient during hospitalization. The rate of adherence by GPs to treatment modifications suggested at discharge from hospital was 83%. In most cases, non-adherence by GPs to treatment modifications done during hospitalization was due to dosage adjustments, symptoms resolution but also worsening of symptoms. The last of which was particularly true for psychotropic drugs. All GPs received their patients' discharge letters but the timely dissemination still needs to be improved. Only 6.6% of community pharmacists were informed of treatment modifications done during their patients' hospitalization. Our findings showed a successful rate of adherence by GPs to treatment modifications suggested at discharge from hospital, due to the fact that optimization was done in a collaborative way between geriatricians and hospital pharmacists and that justifications for drug regimen changes were systematically provided in discharge letters. Communication processes at the interface between secondary and primary care, particularly with community pharmacists, must be strengthened to improve seamless care.

Behavioral management of the obese patient

USDA-ARS?s Scientific Manuscript database

Despite countless diets, exercise regimens, drugs, and behavior modification strategies, the prevalence of obesity continues its relentless increase in both developed and developing nations. Although many necessary components to treat obesity have been identified, behavior modification remains the b...

Lessons From the Dot Contraceptive Efficacy Study: Analysis of the Use of Agile Development to Improve Recruitment and Enrollment for mHealth Research

PubMed Central

2018-01-01

Background Smartphone apps that provide women with information about their daily fertility status during their menstrual cycles can contribute to the contraceptive method mix. However, if these apps claim to help a user prevent pregnancy, they must undergo similar rigorous research required for other contraceptive methods. Georgetown University’s Institute for Reproductive Health is conducting a prospective longitudinal efficacy trial on Dot (Dynamic Optimal Timing), an algorithm-based fertility app designed to help women prevent pregnancy. Objective The aim of this paper was to highlight decision points during the recruitment-enrollment process and the effect of modifications on enrollment numbers and demographics. Recruiting eligible research participants for a contraceptive efficacy study and enrolling an adequate number to statistically assess the effectiveness of Dot is critical. Recruiting and enrolling participants for the Dot study involved making decisions based on research and analytic data, constant process modification, and close monitoring and evaluation of the effect of these modifications. Methods Originally, the only option for women to enroll in the study was to do so over the phone with a study representative. On noticing low enrollment numbers, we examined the 7 steps from the time a woman received the recruitment message until she completed enrollment and made modifications accordingly. In modification 1, we added call-back and voicemail procedures to increase the number of completed calls. Modification 2 involved using a chat and instant message (IM) features to facilitate study enrollment. In modification 3, the process was fully automated to allow participants to enroll in the study without the aid of study representatives. Results After these modifications were implemented, 719 women were enrolled in the study over a 6-month period. The majority of participants (494/719, 68.7%) were enrolled during modification 3, in which they had the option to enroll via phone, chat, or the fully automated process. Overall, 29.2% (210/719) of the participants were enrolled via a phone call, 19.9% (143/719) via chat/IM, and 50.9% (366/719) directly through the fully automated process. With respect to the demographic profile of our study sample, we found a significant statistical difference in education level across all modifications (P<.05) but not in age or race or ethnicity (P>.05). Conclusions Our findings show that agile and consistent modifications to the recruitment and enrollment process were necessary to yield an appropriate sample size. An automated process resulted in significantly higher enrollment rates than one that required phone interaction with study representatives. Although there were some differences in demographic characteristics of enrollees as the process was modified, in general, our study population is diverse and reflects the overall United States population in terms of race/ethnicity, age, and education. Additional research is proposed to identify how differences in mode of enrollment and demographic characteristics may affect participants’ performance in the study. Trial Registration ClinicalTrials.gov NCT02833922; http://clinicaltrials.gov/ct2/show/NCT02833922 (Archived by WebCite at http://www.webcitation.org/6yj5FHrBh) PMID:29678802

High-pressure polymorphism of As2S3 and new AsS2 modification with layered structure

NASA Astrophysics Data System (ADS)

Bolotina, N. B.; Brazhkin, V. V.; Dyuzheva, T. I.; Katayama, Y.; Kulikova, L. F.; Lityagina, L. V.; Nikolaev, N. A.

2014-01-01

At normal pressure, the As2S3 compound is the most stable equilibrium modification with unique layered structure. The possibility of high-pressure polymorphism of this substance remains questionable. Our research showed that the As2S3 substance was metastable under pressures P > 6 GPa decomposing into two high-pressure phases: As2S3 → AsS2 + AsS. New AsS2 phase can be conserved in the single crystalline form in metastable state at room pressure up to its melting temperature (470 K). This modification has the layered structure with P1211 monoclinic symmetry group; the unit-cell values are a = 7.916(2) Å, b = 9.937(2) Å, c = 7.118(1) Å, β = 106.41° ( Z = 8, density 3.44 g/cm3). Along with the recently studied AsS high-pressure modification, the new AsS2 phase suggests that high pressure polymorphism is a very powerful tool to create new layered-structure phases with "wrong" stoichiometry.

40 CFR 51.166 - Prevention of significant deterioration of air quality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... building supports and foundations, laying of underground pipework, and construction of permanent storage... source or modification through application of production processes or available methods, systems, and... application of measurement methodology to a particular emissions unit would make the imposition of an...

Improving the quality of aquatic toxicity tests: Lessons learned and proficiency needs

EPA Science Inventory

Aquatic toxicity testing methodologies have been widely used to assess potential adverse effects of chemicals and wastewater discharges on aquatic life in the United States since the 1970’s. Over the years, continued method modifications, increased training, and technical r...

The National Ambient Air Monitoring Stategy: Rethinking the Role of National Networks

EPA Science Inventory

A current re-engineering of the United States routine ambient monitoring networks intended to improve the balance in addressing both regulatory and scientific objectives is addressed in this paper. Key attributes of these network modifications include the addition of collocated ...

48 CFR 52.214-27 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications-Sealed Bidding.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Contractor or subcontractor took no affirmative action to bring the character of the data to the attention of... and shall pay the United States at the time such overpayment is repaid— (1) Interest compounded daily...

48 CFR 52.214-27 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications-Sealed Bidding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Contractor or subcontractor took no affirmative action to bring the character of the data to the attention of... and shall pay the United States at the time such overpayment is repaid— (1) Interest compounded daily...

48 CFR 52.214-27 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications-Sealed Bidding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Contractor or subcontractor took no affirmative action to bring the character of the data to the attention of... and shall pay the United States at the time such overpayment is repaid— (1) Interest compounded daily...

77 FR 11591 - Certain Ground Fault Circuit Interrupters and Products Containing Same, Investigations...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-739] Certain Ground Fault Circuit Interrupters and Products Containing Same, Investigations: Terminations, Modifications and Rulings AGENCY: U.S... importation, and the sale within the United States after importation of certain ground fault circuit...

A new tool for supervised classification of satellite images available on web servers: Google Maps as a case study

NASA Astrophysics Data System (ADS)

García-Flores, Agustín.; Paz-Gallardo, Abel; Plaza, Antonio; Li, Jun

2016-10-01

This paper describes a new web platform dedicated to the classification of satellite images called Hypergim. The current implementation of this platform enables users to perform classification of satellite images from any part of the world thanks to the worldwide maps provided by Google Maps. To perform this classification, Hypergim uses unsupervised algorithms like Isodata and K-means. Here, we present an extension of the original platform in which we adapt Hypergim in order to use supervised algorithms to improve the classification results. This involves a significant modification of the user interface, providing the user with a way to obtain samples of classes present in the images to use in the training phase of the classification process. Another main goal of this development is to improve the runtime of the image classification process. To achieve this goal, we use a parallel implementation of the Random Forest classification algorithm. This implementation is a modification of the well-known CURFIL software package. The use of this type of algorithms to perform image classification is widespread today thanks to its precision and ease of training. The actual implementation of Random Forest was developed using CUDA platform, which enables us to exploit the potential of several models of NVIDIA graphics processing units using them to execute general purpose computing tasks as image classification algorithms. As well as CUDA, we use other parallel libraries as Intel Boost, taking advantage of the multithreading capabilities of modern CPUs. To ensure the best possible results, the platform is deployed in a cluster of commodity graphics processing units (GPUs), so that multiple users can use the tool in a concurrent way. The experimental results indicate that this new algorithm widely outperform the previous unsupervised algorithms implemented in Hypergim, both in runtime as well as precision of the actual classification of the images.

KSC-08pd1859

NASA Image and Video Library

2008-07-01

CAPE CANAVERAL, Fla. – In the Assembly and Refurbishment Facility at NASA's Kennedy Space Center, a crane is lowered over the aft skirt for the Ares 1-X rocket. The segment is being lifted into a machine shop work stand for drilling modifications. The modifications will prepare it for the installation of the auxiliary power unit controller, the reduced-rate gyro unit, the booster decelerator motors and the booster tumble motors. Ares I is an in-line, two-stage rocket that will transport the Orion crew exploration vehicle to low-Earth orbit. Ares I-X is a test rocket. The Ares I first stage will be a five-segment solid rocket booster based on the four-segment design used for the shuttle. Ares I’s fifth booster segment allows the launch vehicle to lift more weight and reach a higher altitude before the first stage separates from the upper stage, which ignites in midflight to propel the Orion spacecraft to Earth orbit. Photo credit: NASA/Jim Grossmann

Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity.

PubMed

Ui, Mihoko; Harima, Kousuke; Takei, Toshiaki; Tsumoto, Kouhei; Tabata, Kazuhito V; Noji, Hiroyuki; Endo, Sumire; Akiyama, Kimio; Muraoka, Takahiro; Kinbara, Kazushi

2014-12-01

The chemical modification of proteins to provide desirable functions and/or structures broadens their possibilities for use in various applications. Usually, proteins can acquire new functions and characteristics, in addition to their original ones, via the introduction of synthetic functional moieties. Here, we adopted a more radical approach to protein modification, i.e., the replacement of a functional domain of proteins with alternative chemical compounds to build "cyborg proteins." As a proof of concept model, we chose staphylococcal α-hemolysin (Hla), which is a well-studied, pore-forming toxin. The hemolytic activity of Hla mutants was dramatically decreased by truncation of the stem domain, which forms a β-barrel pore in the membrane. However, the impaired hemolytic activity was significantly restored by attaching a pyrenyl-maleimide unit to the cysteine residue that was introduced in the remaining stem domain. In contrast, negatively charged fluorescein-maleimide completely abolished the remaining activity of the mutants.

Low NO{sub x} burner modifications to front-fired pulverized coal boilers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Broderick, R.G.; Wagner, M.

1998-07-01

Madison Gas and Electric Blount Street Station Units 8 and 9 are Babcock and Wilcox pulverized coal fired and natural gas fired boilers. These boilers were build in the late 1950's and early 1960's with each boiler rated at 425,000 lb./hr of steam producing 50 MW of electricity. The boilers are rated at 9,500 F at 1,350 psig. Each unit is equipped with one Ljungstroem air heater and two B and W EL pulverizers. These units burn subbituminous coal with higher heating value of 10,950 Btu/LB on an as-received basis. The nitrogen content is approximately 1.23% with 15% moisture. Inmore » order to comply with the new Clean Air Act Madison Gas and Electric needs to reduce NO{sub x} on these units to less than .5 LB/mmBtu. Baseline NO{sub x} emissions on these units range between .8--.9 lb./mmBtu. LOIs average approximately 8%. Madison Gas and Electric contracted with RJM Corporation to modify the existing burners to achieve this objective. These modifications consisted of adding patented circumferentially and radially staged flame stabilizers, modifying the coal pipe, and replacing the coal impeller with a circumferentially staged coal spreader. RJM Corporation utilized computational fluid dynamics modeling in order to design the equipment to modify these burners. The equipment was installed during the March 1997 outage and start-up and optimization was conducted in April 1997. Final performance results and economic data will be included in the final paper.« less

Prevention: lessons from video display installations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Margach, C.B.

1983-04-01

Workers interacting with video display units for periods in excess of two hours per day report significantly increased visual discomfort, fatigue and inefficiencies, as compared with workers performing similar tasks, but without the video viewing component. Difficulties in focusing and the appearance of myopia are among the problems being described. With a view to preventing or minimizing such problems, principles and procedures are presented providing for (a) modification of physical features of the video workstation and (b) improvement in the visual performances of the individual video unit operator.

Surface Modification and Nanojunction Fabrication with Molecular Wires

DTIC Science & Technology

2016-11-02

currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ORGANIZATION . 1. REPORT DATE (DD-MM-YYYY)      02-11-2016 2. REPORT TYPE...NUMBER 5f.  WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) PURDUE UNIV LAFAYETTE IN 610 Purdue Mall WEST LAFAYETTE, IN 47907-2051 US...8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) AOARD UNIT 45002 APO AP 96338-5002 10. SPONSOR

Challenges and Issues with the Further Aging of U.S. Air Force Aircraft: Policy Options for Effective Life-Cycle Management of Resources

DTIC Science & Technology

2009-01-01

maintenance , and modifications. Value-adding products from this domain could include sufficiency review/analysis for satisfaction of sustainment...c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 This product is part of the RAND Corporation technical...Airplanes, Military—United States— Maintenance and repair. 3. United States. Air Force—Planning. 4. Airplanes—Airworthiness. I. Title. UG1243.G429

Crowdsourcing the Moral Limits of Human Gene Editing?

PubMed

Juengst, Eric T

2017-05-01

In 2015, a flourish of "alarums and excursions" by the scientific community propelled CRISPR/Cas9 and other new gene-editing techniques into public attention. At issue were two kinds of potential gene-editing experiments in humans: those making inheritable germ-line modifications and those designed to enhance human traits beyond what is necessary for health and healing. The scientific consensus seemed to be that while research to develop safe and effective human gene editing should continue, society's moral uncertainties about these two kinds of experiments needed to be better resolved before clinical trials of either type should be attempted. In the United States, the National Academies of Science, Engineering and Medicine (NASEM) convened the Committee on Human Gene Editing: Scientific, Medical and Ethical Considerations to pursue that resolution. The committee's 2017 consensus report has been widely interpreted as "opening the door" to inheritable human genetic modification and holding a line against enhancement interventions. But on a close reading it does neither. There are two reasons for this eccentric conclusion, both of which depend upon the strength of the committee's commitment to engaging diverse public voices in the gene-editing policy-making process. © 2017 The Hastings Center.

Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals.

PubMed

Maynard, Jason C; Burlingame, Alma L; Medzihradszky, Katalin F

2016-11-01

Intracellular GlcNAcylation of Ser and Thr residues is a well-known and widely investigated post-translational modification. This post-translational modification has been shown to play a significant role in cell signaling and in many regulatory processes within cells. O-GlcNAc transferase is the enzyme responsible for glycosylating cytosolic and nuclear proteins with a single GlcNAc residue on Ser and Thr side-chains. Here we report that the same enzyme may also be responsible for S-GlcNAcylation, i.e. for linking the GlcNAc unit to the peptide by modifying a cysteine side-chain. We also report that O-GlcNAcase, the enzyme responsible for removal of O-GlcNAcylation does not appear to remove the S-linked sugar. Such Cys modifications have been detected and identified in mouse and rat samples. This work has established the occurrence of 14 modification sites assigned to 11 proteins unambiguously. We have also identified S-GlcNAcylation from human Host Cell Factor 1 isolated from HEK-cells. Although these site assignments are primarily based on electron-transfer dissociation mass spectra, we also report that S-linked GlcNAc is more stable under collisional activation than O-linked GlcNAc derivatives. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Genetic modification of human trabecular meshwork with lentiviral vectors.

PubMed

Loewen, N; Fautsch, M P; Peretz, M; Bahler, C K; Cameron, J D; Johnson, D H; Poeschla, E M

2001-11-20

Glaucoma, a group of optic neuropathies, is the leading cause of irreversible blindness. Neuronal apoptosis in glaucoma is primarily associated with high intraocular pressure caused by chronically impaired outflow of aqueous humor through the trabecular meshwork, a reticulum of mitotically inactive endothelial-like cells located in the angle of the anterior chamber. Anatomic, genetic, and expression profiling data suggest the possibility of using gene transfer to treat glaucomatous intraocular pressure dysregulation, but this approach will require stable genetic modification of the differentiated aqueous outflow tract. We injected transducing unit-normalized preparations of either of two lentiviral vectors or an oncoretroviral vector as a single bolus into the aqueous circulation of cultured human donor eyes, under perfusion conditions that mimicked natural anterior chamber flow and maintained viability ex vivo. Reporter gene expression was assessed in trabecular meshwork from 3 to 16 days after infusion of 1.0 x 10(8) transducing units of each vector. The oncoretroviral vector failed to transduce the trabecular meshwork. In contrast, feline immunodeficiency virus and human immunodeficiency virus vectors produced efficient, localized transduction of the trabecular meshwork in situ. The results demonstrate that lentiviral vectors permit efficient genetic modification of the human trabecular meshwork when delivered via the afferent aqueous circulation, a clinically accessible route. In addition, controlled comparisons in this study establish that feline and human immunodeficiency virus vectors are equivalently efficacious in delivering genes to this terminally differentiated human tissue.

Web-based Education for Low-literate Parents in Neonatal Intensive Care Unit: Development of a Website and Heuristic Evaluation and Usability Testing

PubMed Central

Choi, Jeungok; Bakken, Suzanne

2010-01-01

Purpose Low health literacy has been associated with poor health-related outcomes. The purposes are to report the development of a website for low-literate parents in the Neonatal Intensive Care Unit (NICU), and the findings of heuristic evaluation and a usability testing of this website. Methods To address low literacy of NICU parents, multimedia educational Website using visual aids (e.g., pictographs, photographs), voice-recorded text message in addition to a simplified text was developed. The text was created at the 5th grade readability level. The heuristic evaluation was conducted by three usability experts using 10 heuristics. End-users’ performance was measured by counting the time spent completing tasks and number of errors, as well as recording users’ perception of ease of use and usefulness (PEUU) in a sample of 10 NICU parents. Results Three evaluators identified 82 violations across the 10 heuristics. All violations, however, received scores <2, indicating minor usability problems. Participants’ time to complete task varies from 81.2 seconds (SD=30.9) to 2.2 seconds (SD=1.3). Participants rated the Website as easy to use and useful (PEUU Mean= 4.52, SD=0.53). Based on the participants’ comments, appropriate modifications were made. Discussion and Conclusions Different types of visuals on the Website were well accepted by low-literate users and agreement of visuals with text improved understanding of the educational materials over that with text alone. The findings suggest that using concrete and realistic pictures and pictographs with clear captions would maximize the benefit of visuals. One emerging theme was “simplicity” in design (e.g., limited use of colors, one font type and size), content (e.g., avoid lengthy text), and technical features (e.g., limited use of pop-ups). The heuristic evaluation by usability experts and the usability test with actual users provided complementary expertise, which can give a richer assessment of a design for low literacy Website. These results facilitated design modification and implementation of solutions by categorizing and prioritizing the usability problems. PMID:20617546

Web-based education for low-literate parents in Neonatal Intensive Care Unit: development of a website and heuristic evaluation and usability testing.

PubMed

Choi, Jeungok; Bakken, Suzanne

2010-08-01

Low health literacy has been associated with poor health-related outcomes. The purposes are to report the development of a website for low-literate parents in the Neonatal Intensive Care Unit (NICU), and the findings of heuristic evaluation and a usability testing of this website. To address low literacy of NICU parents, multimedia educational Website using visual aids (e.g., pictographs, photographs), voice-recorded text message in addition to a simplified text was developed. The text was created at the 5th grade readability level. The heuristic evaluation was conducted by three usability experts using 10 heuristics. End-users' performance was measured by counting the time spent completing tasks and number of errors, as well as recording users' perception of ease of use and usefulness (PEUU) in a sample of 10 NICU parents. Three evaluators identified 82 violations across the 10 heuristics. All violations, however, received scores <2, indicating minor usability problems. Participants' time to complete task varies from 81.2 s (SD = 30.9) to 2.2 s (SD = 1.3). Participants rated the Website as easy to use and useful (PEUU mean = 4.52, SD = 0.53). Based on the participants' comments, appropriate modifications were made. Different types of visuals on the Website were well accepted by low-literate users and agreement of visuals with text improved understanding of the educational materials over that with text alone. The findings suggest that using concrete and realistic pictures and pictographs with clear captions would maximize the benefit of visuals. One emerging theme was "simplicity" in design (e.g., limited use of colors, one font type and size), content (e.g., avoid lengthy text), and technical features (e.g., limited use of pop-ups). The heuristic evaluation by usability experts and the usability test with actual users provided complementary expertise, which can give a richer assessment of a design for low literacy Website. These results facilitated design modification and implementation of solutions by categorizing and prioritizing the usability problems.

Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.

PubMed

Mishima, Eikan; Jinno, Daisuke; Akiyama, Yasutoshi; Itoh, Kunihiko; Nankumo, Shinnosuke; Shima, Hisato; Kikuchi, Koichi; Takeuchi, Yoichi; Elkordy, Alaa; Suzuki, Takehiro; Niizuma, Kuniyasu; Ito, Sadayoshi; Tomioka, Yoshihisa; Abe, Takaaki

2015-01-01

The biological roles of RNA modifications are still largely not understood. Thus, developing a method for detecting RNA modifications is important for further clarification. We developed a method for detecting RNA modifications called immuno-northern blotting (INB) analysis and herein introduce its various capabilities. This method involves the separation of RNAs using either polyacrylamide or agarose gel electrophoresis, followed by transfer onto a nylon membrane and subsequent immunoblotting using antibodies against modified nucleosides for the detection of specific modifications. We confirmed that INB with the antibodies for 1-methyladenosine (m1A), N6-methyladenosine (m6A), pseudouridine, and 5-methylcytidine (m5C) showed different modifications in a variety of RNAs from various species and organelles. INB with the anti-m5C antibody revealed that the antibody cross-reacted with another modification on DNA, suggesting the application of this method for characterization of the antibody for modified nucleosides. Additionally, using INB with the antibody for m1A, which is a highly specific modification in eukaryotic tRNA, we detected tRNA-derived fragments known as tiRNAs under the cellular stress response, suggesting the application for tracking target RNA containing specific modifications. INB with the anti-m6A antibody confirmed the demethylation of m6A by the specific demethylases fat mass and obesity-associated protein (FTO) and ALKBH5, suggesting its application for quantifying target modifications in separated RNAs. Furthermore, INB demonstrated that the knockdown of FTO and ALKBH5 increased the m6A modification in small RNAs as well as in mRNA. The INB method has high specificity, sensitivity, and quantitative capability, and it can be employed with conventional experimental apparatus. Therefore, this method would be useful for research on RNA modifications and metabolism.

12 CFR 1710.30 - Modification of certain provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Modification of certain provisions. 1710.30 Section 1710.30 Banks and Banking OFFICE OF FEDERAL HOUSING ENTERPRISE OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS CORPORATE GOVERNANCE Modification of Certain Provisions...

Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics

NASA Astrophysics Data System (ADS)

Aguilar, Carlos A.; Craighead, Harold G.

2013-10-01

Deoxyribonucleic acid (DNA) is the blueprint on which life is based and transmitted, but the way in which chromatin -- a dynamic complex of nucleic acids and proteins -- is packaged and behaves in the cellular nucleus has only begun to be investigated. Epigenetic modifications sit 'on top of' the genome and affect how DNA is compacted into chromatin and transcribed into ribonucleic acid (RNA). The packaging and modifications around the genome have been shown to exert significant influence on cellular behaviour and, in turn, human development and disease. However, conventional techniques for studying epigenetic or conformational modifications of chromosomes have inherent limitations and, therefore, new methods based on micro- and nanoscale devices have been sought. Here, we review the development of these devices and explore their use in the study of DNA modifications, chromatin modifications and higher-order chromatin structures.

75 FR 6225 - Northern States Power Company-Minnesota; Prairie Island Nuclear Generating Plant Units 1 and 2...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... modifications of this scope, and the impediments to construction such as the planned refueling outages at both... on the Internet at the NRC Web site: http://www.nrc.gov/reading-rm/adams.html . Persons who do not...

33 CFR 332.1 - Purpose and general considerations.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., mitigation banks, and in-lieu fee mitigation to offset unavoidable impacts to waters of the United States... available credits and opportunities for mitigation, provide for regional variations in wetland conditions... and the Corps at the national or regional level. No modifications to the basic application, meaning...

40 CFR 230.91 - Purpose and general considerations.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., mitigation banks, and in-lieu fee mitigation to offset unavoidable impacts to waters of the United States..., provide for regional variations in wetland conditions, functions, and values, and apply equivalent... national or regional level. No modifications to the basic application, meaning, or intent of this subpart...

33 CFR 332.1 - Purpose and general considerations.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., mitigation banks, and in-lieu fee mitigation to offset unavoidable impacts to waters of the United States... available credits and opportunities for mitigation, provide for regional variations in wetland conditions... and the Corps at the national or regional level. No modifications to the basic application, meaning...

The Greenhouse Gases. UNEP/GEMS Environment Library No. 1.

ERIC Educational Resources Information Center

United Nations Environment Programme, Nairobi (Kenya).

Since the United Nations Environment Program (UNEP) was created, more than a dozen years ago, public understanding of the environmental issues confronting our planet has increased enormously. The Global Environment Monitoring System (GEMS) has provided several environmental assessments including urban air pollution, climate modification,…

Energy and Educational Facilities: Costs and Conservation.

ERIC Educational Resources Information Center

Educational Facilities Labs., Inc., New York, NY.

An analysis of energy costs and conservation in educational facilities in the United States is presented in this report. Tables and text give dollar figures for energy expenditures in education since the first oil embargo. Energy conservation through facilities management and through facilities modification is stressed. Recommendations are…

Are High School Students Prepared for a Brave New World?

ERIC Educational Resources Information Center

Blake, Deborah

1984-01-01

Describes Notre Dame High School's (California) integrated bioethics course, which contains units on basic concepts of goals, rights, and duty ethics; reproductive technologies; genetic technologies; death and dying; behavior modification; and experiments with human subjects. Provides a bibliography of student and teacher materials. (DMM)

Selected topics from classical bacterial genetics.

PubMed

Raleigh, Elisabeth A; Elbing, Karen; Brent, Roger

2002-08-01

Current cloning technology exploits many facts learned from classical bacterial genetics. This unit covers those that are critical to understanding the techniques described in this book. Topics include antibiotics, the LAC operon, the F factor, nonsense suppressors, genetic markers, genotype and phenotype, DNA restriction, modification and methylation and recombination.

78 FR 29117 - After Final Consideration Pilot Program 2.0

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

...] After Final Consideration Pilot Program 2.0 AGENCY: United States Patent and Trademark Office, Commerce... Final Consideration Pilot Program (AFCP) to create the After Final Consideration Pilot Program 2.0 (AFCP... without modifications) depending on feedback from the participants and the effectiveness of the pilot...

75 FR 10818 - Proposed Modifications to the Harmonized Tariff Schedule of the United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... international Harmonized System nomenclature. The Recommendation--the fourth in a series--is part of the WCO's... amendments to the international Convention on the Harmonized Commodity Description and Coding System (Harmonized System), and the Protocol thereto, are recommended by [[Page 10819

Development of a Next Generation Air Quality Modeling System

EPA Science Inventory

In the presentation we will describe our modifications to MPAS to improve its suitability for retrospective air quality applications and show evaluations of global and regional meterological simulations. Our modifications include addition of physics schemes that we developed for...

Software Development Standard for Mission Critical Systems

DTIC Science & Technology

2014-03-17

new development, modification, reuse, reengineering, maintenance , or any other activity or combination of activities resulting in products . Within...develops” includes new development, modification, integration, reuse, reengineering, maintenance , or any other activity that results in products ... Maintenance organization. The organization that is responsible for modifying and otherwise sustaining the software and other software products and

Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.

PubMed

Peyrin-Biroulet, Laurent; Billioud, Vincent; D'Haens, Geert; Panaccione, Remo; Feagan, Brian; Panés, Julian; Danese, Silvio; Schreiber, Stefan; Ogata, Haruhiko; Hibi, Toshifumi; Higgins, Peter D R; Beaugerie, Laurent; Chowers, Yehuda; Louis, Edouard; Steinwurz, Flávio; Reinisch, Walter; Rutgeerts, Paul; Colombel, Jean-Frédéric; Travis, Simon; Sandborn, William J

2012-12-01

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.

Cultural traits as units of analysis.

PubMed

O'Brien, Michael J; Lyman, R Lee; Mesoudi, Alex; VanPool, Todd L

2010-12-12

Cultural traits have long been used in anthropology as units of transmission that ostensibly reflect behavioural characteristics of the individuals or groups exhibiting the traits. After they are transmitted, cultural traits serve as units of replication in that they can be modified as part of an individual's cultural repertoire through processes such as recombination, loss or partial alteration within an individual's mind. Cultural traits are analogous to genes in that organisms replicate them, but they are also replicators in their own right. No one has ever seen a unit of transmission, either behavioural or genetic, although we can observe the effects of transmission. Fortunately, such units are manifest in artefacts, features and other components of the archaeological record, and they serve as proxies for studying the transmission (and modification) of cultural traits, provided there is analytical clarity over how to define and measure the units that underlie this inheritance process.

Cultural traits as units of analysis

PubMed Central

O'Brien, Michael J.; Lyman, R. Lee; Mesoudi, Alex; VanPool, Todd L.

2010-01-01

Cultural traits have long been used in anthropology as units of transmission that ostensibly reflect behavioural characteristics of the individuals or groups exhibiting the traits. After they are transmitted, cultural traits serve as units of replication in that they can be modified as part of an individual's cultural repertoire through processes such as recombination, loss or partial alteration within an individual's mind. Cultural traits are analogous to genes in that organisms replicate them, but they are also replicators in their own right. No one has ever seen a unit of transmission, either behavioural or genetic, although we can observe the effects of transmission. Fortunately, such units are manifest in artefacts, features and other components of the archaeological record, and they serve as proxies for studying the transmission (and modification) of cultural traits, provided there is analytical clarity over how to define and measure the units that underlie this inheritance process. PMID:21041205

24 CFR 401.460 - Modification or refinancing of first mortgage.

Code of Federal Regulations, 2013 CFR

2013-04-01

... modification under the Restructuring Plan. The debt service coverage used by the PAE must be adequate for... RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET) Restructuring Plan § 401.460 Modification or refinancing of first...

In silico prediction of post-translational modifications.

PubMed

Liu, Chunmei; Li, Hui

2011-01-01

Methods for predicting protein post-translational modifications have been developed extensively. In this chapter, we review major post-translational modification prediction strategies, with a particular focus on statistical and machine learning approaches. We present the workflow of the methods and summarize the advantages and disadvantages of the methods.

Modifications to the Objective Lightning Probability Forecast Tool at Kennedy Space Center/Cape Canaveral Air Force Station, Florida

NASA Technical Reports Server (NTRS)

Crawford, Winifred; Roeder, William

2010-01-01

The 45th Weather Squadron (45 WS) at Cape Canaveral Air Force Station (CCAFS) includes the probability of lightning occurrence in their 24-Hour and Weekly Planning Forecasts, briefed at 0700 EDT for daily operations planning on Kennedy Space Center (KSC) and CCAFS. This forecast is based on subjective analyses of model and observational data and output from an objective tool developed by the Applied Meteorology Unit (AMU). This tool was developed over two phases (Lambert and Wheeler 2005, Lambert 2007). It consists of five equations, one for each warm season month (May-Sep), that calculate the probability of lightning occurrence for the day and a graphical user interface (GUI) to display the output. The Phase I and II equations outperformed previous operational tools by a total of 56%. Based on this success, the 45 WS tasked the AMU with Phase III to improve the tool further.

Development of flame resistant treatment for Nomex fibrous structures

NASA Technical Reports Server (NTRS)

Toy, M. S.

1977-01-01

Flame resistant fibrous materials for space shuttle application were developed through chemical modification of commercially available aromatic polyamide fibrous products. The new surface treatment was achieved in the laboratory by ultraviolet activation of the fabric in the presence of fluoroolefin monomers and a diluent gas. The monomers grafted under these conditions provide the improved properties of the fabric in flame resistance, chemical inertness, and nonwettability without the sacrifice of color or physical properties. The laboratory reaction vessel was scaled-up to a batch continuous process, which treats ten yards of the commercial width textiles. The treated commercial width Nomex (HT-10-41) from the scaled-up reactor is self-extinguishing in an oxygen-enriched environment, water-repellent, soft, silky, and improved in chemical resistance. Unlike most textile processes, the grafting unit operates under dry conditions and no chemical by-products have to be washed out of the finished product.

Hardware fault insertion and instrumentation system: Mechanization and validation

NASA Technical Reports Server (NTRS)

Benson, J. W.

1987-01-01

Automated test capability for extensive low-level hardware fault insertion testing is developed. The test capability is used to calibrate fault detection coverage and associated latency times as relevant to projecting overall system reliability. Described are modifications made to the NASA Ames Reconfigurable Flight Control System (RDFCS) Facility to fully automate the total test loop involving the Draper Laboratories' Fault Injector Unit. The automated capability provided included the application of sequences of simulated low-level hardware faults, the precise measurement of fault latency times, the identification of fault symptoms, and bulk storage of test case results. A PDP-11/60 served as a test coordinator, and a PDP-11/04 as an instrumentation device. The fault injector was controlled by applications test software in the PDP-11/60, rather than by manual commands from a terminal keyboard. The time base was especially developed for this application to use a variety of signal sources in the system simulator.

Portable Medical System

NASA Technical Reports Server (NTRS)

1982-01-01

Portable Medical Status and Treatment System (PMSTS) is designed for use in remote areas where considerable time may elapse before a patient can be transported to a hospital. First units were delivered to the Department of Transportation last year and tested in two types of medical emergency environments: one in a rural Pennsylvania community and another aboard a U.S. Coast Guard rescue helicopter operating along Florida's Gulf Coast. The system has the capability to transmit vital signs to a distantly located physician, who can perform diagnosis and relay treatment instructions to the attendant at the scene. The battery powered PMSTS includes a vital signs monitor and a defibrillator. Narco has also developed a companion system, called Porta-Fib III designed for use in a hospital environment with modifications accordingly. Both systems are offshoots of an earlier NASA project known as the Physician's Black Bag developed by Telecare, Inc., a company now acquired by NARCO.

Pretreatment and Membrane Hydrophilic Modification to Reduce Membrane Fouling

PubMed Central

Sun, Wen; Liu, Junxia; Chu, Huaqiang; Dong, Bingzhi

2013-01-01

The application of low pressure membranes (microfiltration/ultrafiltration) has undergone accelerated development for drinking water production. However, the major obstacle encountered in its popularization is membrane fouling caused by natural organic matter (NOM). This paper firstly summarizes the two factors causing the organic membrane fouling, including molecular weight (MW) and hydrophilicity/hydrophobicity of NOM, and then presents a brief introduction of the methods which can prevent membrane fouling such as pretreatment of the feed water (e.g., coagulation, adsorption, and pre-oxidation) and membrane hydrophilic modification (e.g., plasma modification, irradiation grafting modification, surface coating modification, blend modification, etc.). Perspectives of further research are also discussed. PMID:24956947

Genetic modification and genetic determinism

PubMed Central

Resnik, David B; Vorhaus, Daniel B

2006-01-01

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions. PMID:16800884

Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins.

PubMed

Deming, Timothy J

2017-03-15

Recent developments in the modification of methionine and other thioether-containing residues in peptides, polypeptides, and proteins are reviewed. Properties and potential applications of the resulting functionalized products are also discussed. While much of this work is focused on natural Met residues, modifications at other side-chain residues have also emerged as new thioether-containing amino acids have been incorporated into peptidic materials. Functional modification of thioether-containing amino acids has many advantages and is a complementary methodology to the widely utilized methods for modification at cysteine residues.

Engineering aids for the design of survivable defense communications transmission capability

NASA Astrophysics Data System (ADS)

Stover, H. A.

1984-01-01

Adequate military communications are essential to the security of the United States, especially in the various stages of major wars. Enough communications must survive to make effective use of our military forces and weaponry, even in the face of a concerted enemy effort to destroy those communications. An evolutionary approach to provide survivability is recommended. It must be provided by the design engineer. Afterthought and modification must be replaced with foresight and design. The engineer must make survivability a criterion in every design decision. The design engineer needs help with the challenges and associated details of successfully accomplishing this. The author discusses and recommends development of convenient-to-use survivability engineering design tools to provide this help.

[Comparative anatomy of the mandible. Functional aspects].

PubMed

Denoix, J M

1983-12-01

The structural morphology of the mandibula is presented and correlated to various types of mastication in several Mammalian species. The latter include: Carnivores (Dog, Cat, Cheetah, Lion); Omnivores (Man, Chimpanzee, Hog); Herbivores (Horse, Ox, Goat, Camel, Rabbit). While the mandibula is studied as a composite unit, a more analytical, segmental approach has been included, and both are illustrated by X-rays. The aspects presented underline the distribution as well as the local modifications of compact bone, and in addition, the arrangement and the development of spongy bone trabeculae. A preliminary classification with respect to structural elements has been suggested from two viewpoints: that of tension, the other of compression. Are also presented those variations linked to diet and alimentary intake, as well as their functional correlates.

Solar thermal plant impact analysis and requirements definition

NASA Technical Reports Server (NTRS)

Gupta, Y. P.

1980-01-01

Progress on a continuing study comprising of ten tasks directed at defining impact and requirements for solar thermal power systems (SPS), 1 to 10 MWe each in capacity, installed during 1985 through year 2000 in a utility or a nonutility load in the United States is summarized. The point focus distributed receiver (PFDR) solar power systems are emphasized. Tasks 1 through 4, completed to date, include the development of a comprehensive data base on SPS configurations, their performance, cost, availability, and potential applications; user loads, regional characteristics, and an analytic methodology that incorporates the generally accepted utility financial planning methods and several unique modifications to treat the significant and specific characteristics of solar power systems deployed in either central or distributed power generation modes, are discussed.

Post-Translational Modifications of Nucleosomal Histones in Oligodendrocyte Lineage Cells in Development and Disease

PubMed Central

Shen, Siming; Casaccia-Bonnefil, Patrizia

2008-01-01

The role of epigenetics in modulating gene expression in the development of organs and tissues and in disease states is becoming increasingly evident. Epigenetics refers to the several mechanisms modulating inheritable changes in gene expression that are independent of modifications of the primary DNA sequence and include post-translational modifications of nucleosomal histones, changes in DNA methylation, and the role of microRNA. This review focuses on the epigenetic regulation of gene expression in oligodendroglial lineage cells. The biological effects that post-translational modifications of critical residues in the N-terminal tails of nucleosomal histones have on oligodendroglial cells are reviewed, and the implications for disease and repair are critically discussed. PMID:17999198

Organization of the BcgI restriction-modification protein for the cleavage of eight phosphodiester bonds in DNA

PubMed Central

Smith, Rachel M.; Marshall, Jacqueline J. T.; Jacklin, Alistair J.; Retter, Susan E.; Halford, Stephen E.; Sobott, Frank

2013-01-01

Type IIB restriction-modification systems, such as BcgI, feature a single protein with both endonuclease and methyltransferase activities. Type IIB nucleases require two recognition sites and cut both strands on both sides of their unmodified sites. BcgI cuts all eight target phosphodiester bonds before dissociation. The BcgI protein contains A and B polypeptides in a 2:1 ratio: A has one catalytic centre for each activity; B recognizes the DNA. We show here that BcgI is organized as A2B protomers, with B at its centre, but that these protomers self-associate to assemblies containing several A2B units. Moreover, like the well known FokI nuclease, BcgI bound to its site has to recruit additional protomers before it can cut DNA. DNA-bound BcgI can alternatively be activated by excess A subunits, much like the activation of FokI by its catalytic domain. Eight A subunits, each with one centre for nuclease activity, are presumably needed to cut the eight bonds cleaved by BcgI. Its nuclease reaction may thus involve two A2B units, each bound to a recognition site, with two more A2B units bridging the complexes by protein–protein interactions between the nuclease domains. PMID:23147005

The WINCOF-I code: Detailed description

NASA Technical Reports Server (NTRS)

Murthy, S. N. B.; Mullican, A.

1993-01-01

The performance of an axial-flow fan-compressor unit is basically unsteady when there is ingestion of water along with the gas phase. The gas phase is a mixture of air and water vapor in the case of a bypass fan engine that provides thrust power to an aircraft. The liquid water may be in the form of droplets and film at entry to the fan. The unsteadiness is then associated with the relative motion between the gas phase and water, at entry and within the machine, while the water undergoes impact on material surfaces, centrifuging, heat and mass transfer processes, and reingestion in blade wakes, following peal off from blade surfaces. The unsteadiness may be caused by changes in atmospheric conditions and at entry into and exit from rain storms while the aircraft is in flight. In a multi-stage machine, with an uneven distribution of blade tip clearance, the combined effect of various processes in the presence of steady or time-dependent ingestion is such as to make the performance of a fan and a compressor unit time-dependent from the start of ingestion up to a short time following termination of ingestion. The original WINCOF code was developed without accounting for the relative motion between gas and liquid phases in the ingested fluid. A modification of the WINCOF code was developed and named WINCOF-1. The WINCOF-1 code can provide the transient performance of a fan-compressor unit under a variety of input conditions.

Hydrologic restoration in a dynamic subtropical mangrove-to-marsh ecotone

USGS Publications Warehouse

Howard, Rebecca J.; Day, Richard H.; Krauss, Ken W.; From, Andrew S.; Allain, Larry K.; Cormier, Nicole

2017-01-01

Extensive hydrologic modifications in coastal regions across the world have occurred to support infrastructure development, altering the function of many coastal wetlands. Wetland restoration success is dependent on the existence of hydrologic regimes that support development of appropriate soils and the growth and persistence of wetland vegetation. In Florida, United States, the Comprehensive Everglades Restoration Program (CERP) seeks to restore, protect, and preserve water resources of the greater Everglades region. Herein we describe vegetation dynamics in a mangrove-to-marsh ecotone within the impact area of a CERP hydrologic restoration project currently under development. Vegetation communities are also described for a similar area outside the project area. We found that vegetation shifts within the impact area occurred over a 7-year period; cover of herbaceous species varied by location, and an 88% increase in the total number of mangrove seedlings was documented. We attribute these shifts to the existing modified hydrologic regime, which is characterized by a low volume of freshwater sheet flow compared with historical conditions (i.e. before modification), as well as increased tidal influence. We also identified a significant trend of decreasing soil surface elevation at the impact area. The CERP restoration project is designed to increase freshwater sheet flow to the impact area. Information from our study characterizing existing vegetation dynamics prior to implementation of the restoration project is required to allow documentation of long-term project effects on plant community composition and structure within a framework of background variation, thereby allowing assessment of the project's success in restoring critical ecosystem functions.

21 CFR 26.0 - General.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Between the United States of America and the European Community” (the MRA), signed at London May 18, 1998. For codification purposes, certain provisions of the MRA have been modified for use in this part. This modification is done for purposes of clarity only and shall not affect the text of the MRA concluded between...

21 CFR 26.0 - General.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Between the United States of America and the European Community” (the MRA), signed at London May 18, 1998. For codification purposes, certain provisions of the MRA have been modified for use in this part. This modification is done for purposes of clarity only and shall not affect the text of the MRA concluded between...

21 CFR 26.0 - General.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Between the United States of America and the European Community” (the MRA), signed at London May 18, 1998. For codification purposes, certain provisions of the MRA have been modified for use in this part. This modification is done for purposes of clarity only and shall not affect the text of the MRA concluded between...

21 CFR 26.0 - General.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Between the United States of America and the European Community” (the MRA), signed at London May 18, 1998. For codification purposes, certain provisions of the MRA have been modified for use in this part. This modification is done for purposes of clarity only and shall not affect the text of the MRA concluded between...

263. Photocopy of drawing (1977 piping drawing by StearnsRoger Incorporated) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

263. Photocopy of drawing (1977 piping drawing by Stearns-Roger Incorporated) NOAA MODIFICATION, SECTIONS FOR NITROGEN SUPPLY CABINET FOR INERTIAL MEASUREMENT UNIT, SHEET 501-P8 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

77 FR 16066 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-19

... addressing Privacy Act amendment appeals; and minor modifications throughout the notice to reflect the name... DEPARTMENT OF JUSTICE [CPCLO Order No. 004-2012] Privacy Act of 1974; System of Records AGENCY: United States Department of Justice. ACTION: Modified system of records. SUMMARY: Pursuant to the Privacy...

78 FR 12368 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... POSTAL SERVICE Privacy Act of 1974; System of Records AGENCY: Postal Service\\TM\\. ACTION: Notice of modification to existing system of records. SUMMARY: The United States Postal Service[supreg] is proposing to modify a General Privacy Act System of Records. These updates are being made due to changes to...

75 FR 27229 - Proposed Modification of Class B Airspace; Chicago, IL

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... International (HAI), the United States Parachute Association (USPA), airline pilot groups, airlines, soaring... overlay the airfields where the Sky Soaring Glider Club (Hampshire, IL) and Windy City Soaring Association... entities. International Trade Impact Assessment The Trade Agreements Act of 1979 (Pub. L. 96-39), as...

REDUCING DIESEL NOX AND SOOT EMISSIONS VIA PARTICLE-FREE EXHAUST GAS RECIRCULATION - PHASE I

EPA Science Inventory

Diesel engines play an important role in the United States economy for power generation and transportation. However, NOx and soot emissions from both stationary and mobile diesel engines are a major contributor to air pollution. Many engine modifications and exhaust-after-t...

Getting Results: Small Changes, Big Cohorts and Technology

ERIC Educational Resources Information Center

Kenney, Jacqueline L.

2012-01-01

This paper presents an example of constructive alignment in practice. Integrated technology supports were deployed to increase the consistency between learning objectives, activities and assessment and to foster student-centred, higher-order learning processes in the unit. Modifications took place over nine iterations of a second-year Marketing…

The colloidal chemistry of ceramic clays

NASA Technical Reports Server (NTRS)

Phelps, G. W.

1984-01-01

The colloidal chemistry and mineralogy of two argil minerals were studied. Deposits of kaolin and of ceramic clays in the United States and England are discussed for the probable mechanism of formation. The structural modifications of the bed, original material associated with the clays and the proper use of flocculants are discussed.

77 FR 34211 - Modification of Multiple Compulsory Reporting Points; Continental United States, Alaska and Hawaii

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... previously updated in the FAA aeronautical database without accompanying regulatory action being taken. The... to ensure it matches the information contained in the FAA's aeronautical database and to ensure the... position information contained in the FAA's aeronautical database for the reporting points. When these...

10 CFR 430.24 - Units to be tested.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the method includes an ARM/simulation adjustment factor(s), determine the value(s) of the factors(s... process. (v) If request for approval is for an updated ARM, manufacturers must identify modifications made to the ARM since the last submittal, including any ARM/simulation adjustment factor(s) added since...

A bill to amend title 49, United States Code, to make technical and minor modifications to the positive train control requirements under chapter 201.

THOMAS, 112th Congress

Sen. Hutchison, Kay Bailey [R-TX

2011-02-08

Senate - 02/08/2011 Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

75 FR 61572 - Change to “Procedures To Qualify for Bulk Purchase of Silver Bullion Coins”

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... effective immediately. Significant modifications include the addition of the America the Beautiful Silver... ``Marketing Support'' section, and adjustments to the ``Experienced Market-Maker in Silver Bullion Coins... FURTHER INFORMATION CONTACT: B. B. Craig, Associate Director for Sales and Marketing; United States Mint...

75 FR 53024 - Change to “Procedures To Qualify for Bulk Purchase of Gold Bullion Coins”

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

....usmint.gov/consumer/index.cfm?action=AmericanEagles ) These changes apply to new applications effective immediately. Significant modifications include clarifications to the ``Purpose'' section and ``Marketing... FURTHER INFORMATION CONTACT: B. B. Craig, Associate Director for Sales and Marketing; United States Mint...

A Signalling Device for Non-Oral Communicators.

ERIC Educational Resources Information Center

King, Thomas W.

1991-01-01

This article describes simple modifications to a basic 9-volt portable transistor radio to serve as a durable, inexpensive signalling device operable by a single external switch. The unit still functions as a radio, but can also help partially speaking students and users of communication aids to signal for help. (Author/PB)

75 FR 41529 - Petitions for Modification

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-16

... number'' on the subject line, by any of the following methods: 1. Electronic Mail: Standards-Petitions... permissible pump trailing cables will not be smaller than 10 American Wire Gauge (AWG); (4) all circuit... will have an instantaneous trip unit calibrated to trip at 70 percent of phase-to-phase short-circuit...

75 FR 12793 - Petitions for Modification

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

... number'' on the subject line, by any of the following methods: 1. Electronic Mail: Standards-Petitions... cables will be no smaller than 10 American Wire Gauge (AWG); (4) all circuit breakers used to protect... unit calibrated to trip at 70% of phase to phase short circuit current. The trip setting of these...

Novel plasticity rule can explain the development of sensorimotor intelligence

PubMed Central

Der, Ralf; Martius, Georg

2015-01-01

Grounding autonomous behavior in the nervous system is a fundamental challenge for neuroscience. In particular, self-organized behavioral development provides more questions than answers. Are there special functional units for curiosity, motivation, and creativity? This paper argues that these features can be grounded in synaptic plasticity itself, without requiring any higher-level constructs. We propose differential extrinsic plasticity (DEP) as a new synaptic rule for self-learning systems and apply it to a number of complex robotic systems as a test case. Without specifying any purpose or goal, seemingly purposeful and adaptive rhythmic behavior is developed, displaying a certain level of sensorimotor intelligence. These surprising results require no system-specific modifications of the DEP rule. They rather arise from the underlying mechanism of spontaneous symmetry breaking, which is due to the tight brain body environment coupling. The new synaptic rule is biologically plausible and would be an interesting target for neurobiological investigation. We also argue that this neuronal mechanism may have been a catalyst in natural evolution. PMID:26504200

Potential reduction of non-residential solid waste in Sukomanunggal district West Surabaya

NASA Astrophysics Data System (ADS)

Warmadewanthi, I. D. A. A.; Reswari, S. A.

2018-01-01

Sukomanunggal district a development unit 8 with the designation as a regional trade and services, industrial, education, healthcare, offices, and shopping center. The development of this region will make an increasing solid waste generation, especially waste from non-residential facilities. The aims of this research to know the potential reduction of waste source. The method used is the Likert scale questionnaire to determine the knowledge, attitude, and behavior of non-residential facilities manager. Results from this research are the existing reduction of non-residential solid waste is 5.34%, potential reduction of the waste source is optimization of plastic and paper waste with the reduction rate up to 19,52%. The level of public participation existing amounted to 46.79% with a willingness to increase recycling efforts amounted to 72.87%. Efforts that can be developed to increase public awareness of 3R are providing three types of bins, modification of solid waste collection schedule according to a type of waste that has been sorted, the provision of the communal bin.

Overview of NASA Lewis Research Center free-piston Stirling engine activities

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1984-01-01

A generic free-piston Stirling technology project is being conducted to develop technologies generic to both space power and terrestrial heat pump applications in a cooperative, cost-shared effort. The generic technology effort includes extensive parametric testing of a 1 kW free-piston Stirling engine (RE-1000), development of a free-piston Stirling performance computer code, design and fabrication under contract of a hydraulic output modification for RE-1000 engine tests, and a 1000-hour endurance test, under contract, of a 3 kWe free-piston Stirling/alternator engine. A newly initiated space power technology feasibility demonstration effort addresses the capability of scaling a free-piston Stirling/alternator system to about 25 kWe; developing thermodynamic cycle efficiency or equal to 70 percent of Carnot at temperature ratios in the order of 1.5 to 2.0; achieving a power conversion unit specific weight of 6 kg/kWe; operating with noncontacting gas bearings; and dynamically balancing the system. Planned engine and component design and test efforts are described.

Optimized methods of chromatin immunoprecipitation for profiling histone modifications in industrial microalgae Nannochloropsis spp.

PubMed

Wei, Li; Xu, Jian

2018-06-01

Epigenetic factors such as histone modifications play integral roles in plant development and stress response, yet their implications in algae remain poorly understood. In the industrial oleaginous microalgae Nannochloropsis spp., the lack of an efficient methodology for chromatin immunoprecipitation (ChIP), which determines the specific genomic location of various histone modifications, has hindered probing the epigenetic basis of their photosynthetic carbon conversion and storage as oil. Here, a detailed ChIP protocol was developed for Nannochloropsis oceanica, which represents a reliable approach for the analysis of histone modifications, chromatin state, and transcription factor-binding sites at the epigenetic level. Using ChIP-qPCR, genes related to photosynthetic carbon fixation in this microalga were systematically assessed. Furthermore, a ChIP-Seq protocol was established and optimized, which generated a genome-wide profile of histone modification events, using histone mark H3K9Ac as an example. These results are the first step for appreciation of the chromatin landscape in industrial oleaginous microalgae and for epigenetics-based microalgal feedstock development. © 2018 Phycological Society of America.

Determination of Optimum Cross-section for Oran Highway Revetment

NASA Astrophysics Data System (ADS)

Velioglu, Deniz; Sogut, Erdinc; Guler, Isikhan

2017-04-01

Revetments are shore parallel, sloping coastal structures which are built to provide protection from the negative effects of the sea. The revetment mentioned in this study is located in the City of Oran, Algeria and is currently under construction. This study investigates the determination of the optimum revetment cross section for Oran highway, considering both the hydraulic stability of the revetment and economy. The existence of cliffs in the region and the settlement of the City of Oran created a necessity to re-align Oran highway; therefore, it was shifted towards the Gulf of Oran. Approximately 1 km of the highway is to be constructed on the Mediterranean Sea due to the new alignment. In order to protect the sea side of the road from the adverse effects of the sea, a revetment was designed. The proposed cross section had an armour layer composed of 23 tons of antifer units and regular placement of armour units was recommended. In order to check the hydraulic stability of the proposed section, physical model tests were performed in the laboratory of LEM (Laboratoire d'Etudes Maritimes) in Algeria, using the pre-determined design wave conditions. The physical model tests revealed that the trunk of the revetment was totaly damaged. Accordingly, the proposed section was found insufficient and certain modifications were required. The first modification was made in the arrangement of armour units, changing them from regular to irregular. After testing the new cross section, it was observed that the revetment was vulnerable to breaking wave attack due to the toe geometry and thus the toe of the revetment had to be re-shaped. Therefore, the second option was to reduce the toe elevation. It was observed that even though the revetment trunk was safe, the damage in the toe was not in acceptable limits. The new cross section was found insufficient and as the final option, the weight of the antifer units used in the armour layer was increased, the toe length of the structure was increased and the size of the armour units in the toe was decreased. After the modifications, the new section was tested physically and it was selected as the most optimum option. Acknowledgements: Yuksel Proje Uluslararasi A.S. is acknowledged for its contributon to this study.

Germline Modification and Engineering in Avian Species

PubMed Central

Lee, Hong Jo; Lee, Hyung Chul; Han, Jae Yong

2015-01-01

Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies. PMID:26333275

77 FR 58983 - New England Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-25

...-0492. SUPPLEMENTARY INFORMATION: The Habitat Advisory Panel and Plan Development Team will review and further develop alternatives for Omnibus Essential Fish Habitat Amendment 2. Related to gear modification options for Habitat Management Areas, they will discuss ground cable modification options in general and...

Effects of ionospheric modification on system performance

NASA Astrophysics Data System (ADS)

Ganguly, Suman

1989-12-01

Controlled ionospheric modification can be used for disrupting as well as facilitating communication and radar systems. After briefly describing the results achieved with the present day ionospheric modification facilities, a scenario is presented for the generation of strong and significant ionospheric modification. A few schemes are presented for the development of modern high power facilities using the state of the art technology and then the impact of such facilities on the system performance is described.

Change of the isoelectric point of hemoglobin at the air/water interface probed by the orientational flip-flop of water molecules.

PubMed

Devineau, Stéphanie; Inoue, Ken-Ichi; Kusaka, Ryoji; Urashima, Shu-Hei; Nihonyanagi, Satoshi; Baigl, Damien; Tsuneshige, Antonio; Tahara, Tahei

2017-04-19

Elucidation of the molecular mechanisms of protein adsorption is of essential importance for further development of biotechnology. Here, we use interface-selective nonlinear vibrational spectroscopy to investigate protein charge at the air/water interface by probing the orientation of interfacial water molecules. We measured the Im χ (2) spectra of hemoglobin, myoglobin, serum albumin and lysozyme at the air/water interface in the CH and OH stretching regions using heterodyne-detected vibrational sum frequency generation (HD-VSFG) spectroscopy, and we deduced the isoelectric point of the protein by monitoring the orientational flip-flop of water molecules at the interface. Strikingly, our measurements indicate that the isoelectric point of hemoglobin is significantly lowered (by about one pH unit) at the air/water interface compared to that in the bulk. This can be predominantly attributed to the modifications of the protein structure at the air/water interface. Our results also suggest that a similar mechanism accounts for the modification of myoglobin charge at the air/water interface. This effect has not been reported for other model proteins at interfaces probed by conventional VSFG techniques, and it emphasizes the importance of the structural modifications of proteins at the interface, which can drastically affect their charge profiles in a protein-specific manner. The direct experimental approach using HD-VSFG can unveil the changes of the isoelectric point of adsorbed proteins at various interfaces, which is of major relevance to many biological applications and sheds new light on the effect of interfaces on protein charge.

A Standardized Relative Resource Cost Model for Medical Care: Application to Cancer Control Programs

PubMed Central

2013-01-01

Medicare data represent 75% of aged and permanently disabled Medicare beneficiaries enrolled in the fee-for-service (FFS) indemnity option, but the data omit 25% of beneficiaries enrolled in Medicare Advantage health maintenance organizations (HMOs). Little research has examined how longitudinal patterns of utilization differ between HMOs and FFS. The Burden of Cancer Study developed and implemented an algorithm to assign standardized relative costs to HMO and Medicare FFS data consistently across time and place. Medicare uses 15 payment systems to reimburse FFS providers for covered services. The standardized relative resource cost algorithm (SRRCA) adapts these various payment systems to utilization data. We describe the rationale for modifications to the Medicare payment systems and discuss the implications of these modifications. We applied the SRRCA to data from four HMO sites and the linked Surveillance, Epidemiology, and End Results–Medicare data. Some modifications to Medicare payment systems were required, because data elements needed to categorize utilization were missing from both data sources. For example, data were not available to create episodes for home health services received, so we assigned costs per visit based on visit type (nurse, therapist, and aide). For inpatient utilization, we modified Medicare’s payment algorithm by changing it from a flat payment per diagnosis-related group to daily rates for diagnosis-related groups to differentiate shorter versus longer stays. The SRRCA can be used in multiple managed care plans and across multiple FFS delivery systems within the United States to create consistent relative cost data for economic analyses. Prior to international use of the SRRCA, data need to be standardized. PMID:23962514

O-Linked β-N-acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy.

PubMed

Gurel, Zafer; Sheibani, Nader

2018-01-31

The incidence of diabetes continues to rise among all ages and ethnic groups worldwide. Diabetic retinopathy (DR) is a complication of diabetes that affects the retinal neurovasculature causing serious vision problems, including blindness. Its pathogenesis and severity is directly linked to the chronic exposure to high glucose conditions. No treatments are currently available to stop the development and progression of DR. To develop new and effective therapeutic approaches, it is critical to better understand how hyperglycemia contributes to the pathogenesis of DR at the cellular and molecular levels. We propose alterations in O-GlcNAc modification of target proteins during diabetes contribute to the development and progression of DR. The O-GlcNAc modification is regulated through hexosamine biosynthetic pathway. We showed this pathway is differentially activated in various retinal vascular cells under high glucose conditions perhaps due to their selective metabolic activity. O-GlcNAc modification can alter protein stability, activity, interactions, and localization. By targeting the same amino acid residues (serine and threonine) as phosphorylation, O-GlcNAc modification can either compete or cooperate with phosphorylation. Here we will summarize the effects of hyperglycemia-induced O-GlcNAc modification on the retinal neurovasculature in a cell-specific manner, providing new insight into the role of O-GlcNAc modification in early loss of retinal pericytes and the pathogenesis of DR. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Modification and optimization of the united-residue (UNRES) potential-energy function for canonical simulations. I. Temperature dependence of the effective energy function and tests of the optimization method with single training proteins

PubMed Central

Liwo, Adam; Khalili, Mey; Czaplewski, Cezary; Kalinowski, Sebastian; Ołdziej, Stanisław; Wachucik, Katarzyna; Scheraga, Harold A.

2011-01-01

We report the modification and parameterization of the united-residue (UNRES) force field for energy-based protein-structure prediction and protein-folding simulations. We tested the approach on three training proteins separately: 1E0L (β), 1GAB (α), and 1E0G (α + β). Heretofore, the UNRES force field had been designed and parameterized to locate native-like structures of proteins as global minima of their effective potential-energy surfaces, which largely neglected the conformational entropy because decoys composed of only lowest-energy conformations were used to optimize the force field. Recently, we developed a mesoscopic dynamics procedure for UNRES, and applied it with success to simulate protein folding pathways. How ever, the force field turned out to be largely biased towards α-helical structures in canonical simulations because the conformational entropy had been neglected in the parameterization. We applied the hierarchical optimization method developed in our earlier work to optimize the force field, in which the conformational space of a training protein is divided into levels each corresponding to a certain degree of native-likeness. The levels are ordered according to increasing native-likeness; level 0 corresponds to structures with no native-like elements and the highest level corresponds to the fully native-like structures. The aim of optimization is to achieve the order of the free energies of levels, decreasing as their native-likeness increases. The procedure is iterative, and decoys of the training protein(s) generated with the energy-function parameters of the preceding iteration are used to optimize the force field in a current iteration. We applied the multiplexing replica exchange molecular dynamics (MREMD) method, recently implemented in UNRES, to generate decoys; with this modification, conformational entropy is taken into account. Moreover, we optimized the free-energy gaps between levels at temperatures corresponding to a predominance of folded or unfolded structures, as well as to structures at the putative folding-transition temperature, changing the sign of the gaps at the transition temperature. This enabled us to obtain force fields characterized by a single peak in the heat capacity at the transition temperature. Furthermore, we introduced temperature dependence to the UNRES force field; this is consistent with the fact that it is a free-energy and not a potential-energy function. PMID:17201450

α-Amino acid containing degradable polymers as functional biomaterials: rational design, synthetic pathway, and biomedical applications.

PubMed

Sun, Huanli; Meng, Fenghua; Dias, Aylvin A; Hendriks, Marc; Feijen, Jan; Zhong, Zhiyuan

2011-06-13

Currently, biomedical engineering is rapidly expanding, especially in the areas of drug delivery, gene transfer, tissue engineering, and regenerative medicine. A prerequisite for further development is the design and synthesis of novel multifunctional biomaterials that are biocompatible and biologically active, are biodegradable with a controlled degradation rate, and have tunable mechanical properties. In the past decades, different types of α-amino acid-containing degradable polymers have been actively developed with the aim to obtain biomimicking functional biomaterials. The use of α-amino acids as building units for degradable polymers may offer several advantages: (i) imparting chemical functionality, such as hydroxyl, amine, carboxyl, and thiol groups, which not only results in improved hydrophilicity and possible interactions with proteins and genes, but also facilitates further modification with bioactive molecules (e.g., drugs or biological cues); (ii) possibly improving materials biological properties, including cell-materials interactions (e.g., cell adhesion, migration) and degradability; (iii) enhancing thermal and mechanical properties; and (iv) providing metabolizable building units/blocks. In this paper, recent developments in the field of α-amino acid-containing degradable polymers are reviewed. First, synthetic approaches to prepare α-amino acid-containing degradable polymers will be discussed. Subsequently, the biomedical applications of these polymers in areas such as drug delivery, gene delivery and tissue engineering will be reviewed. Finally, the future perspectives of α-amino acid-containing degradable polymers will be evaluated.

Development and research program for a soil-based bioregenerative agriculture system to feed a four person crew at a Mars base

NASA Astrophysics Data System (ADS)

Silverstone, S.; Nelson, M.; Alling, A.; Allen, J.

For humans to survive during long-term missions on the Martian surface, bioregenerative life support systems including food production will decrease requirements for launch of Earth supplies, and increase mission safety. It is proposed that the development of ``modular biospheres''- closed system units that can be air-locked together and which contain soil-based bioregenerative agriculture, horticulture, with a wetland wastewater treatment system is an approach for Mars habitation scenarios. Based on previous work done in long-term life support at Biosphere 2 and other closed ecological systems, this consortium proposes a research and development program called Mars On Earth™ which will simulate a life support system designed for a four person crew. The structure will consist of /6 × 110 square meter modular agricultural units designed to produce a nutritionally adequate diet for 4 people, recycling all air, water and waste, while utilizing a soil created by the organic enrichment and modification of Mars simulant soils. Further research needs are discussed, such as determining optimal light levels for growth of the necessary range of crops, energy trade-offs for agriculture (e.g. light intensity vs. required area), capabilities of Martian soils and their need for enrichment and elimination of oxides, strategies for use of human waste products, and maintaining atmospheric balance between people, plants and soils.

A comprehensive space management model for facilitating programmatic research.

PubMed

Libecap, Ann; Wormsley, Steven; Cress, Anne; Matthews, Mary; Souza, Angie; Joiner, Keith A

2008-03-01

In FY04, the authors developed and implemented models to manage existing and incremental research space, and to facilitate programmatic research, at the University of Arizona College of Medicine. Benchmarks were set for recovery of total sponsored research dollars and for facilities and administrative (F&A) dollars/net square foot (nsf) of space, based on college-wide metrics. Benchmarks were applied to units (departments, centers), rather than to individual faculty. Performance relative to the benchmark was assessed using three-year moving averages, and applied to existing blocks of space. Space was recaptured or allocated, in all cases to programmatic themes, using uniform policies. F&A revenues were returned on the basis of performance relative to a benchmark. During the first two years after implementation of the model (FY05 and FY06), and for the 24 units occupying research space, median total sponsored research revenue/nsf increased from $393.96 to $474.46 (20.4%), and median F&A revenue/nsf increased from $57.42 to $91.86 (60.0%). These large increases in median values are driven primarily from redistribution and recapturing of space. Recruiting policies for unit heads were developed to facilitate joint hires among units. In combination, these policies created a comprehensive space management model for facilitating programmatic research. Although challenges remain in implementing the programmatic recruitment strategy, and selected modifications to the original policy were introduced later (e.g., research space for newly recruited junior faculty is now exempted from calculations for three years), overall, the models have created a climate of transparency that is now accepted and that allows efficient and equitable management of research space.

A coumaroyl-ester-3-hydroxylase Insertion Mutant Reveals the Existence of Nonredundant meta-Hydroxylation Pathways and Essential Roles for Phenolic Precursors in Cell Expansion and Plant Growth1[W][OA

PubMed Central

Abdulrazzak, Nawroz; Pollet, Brigitte; Ehlting, Jürgen; Larsen, Kim; Asnaghi, Carole; Ronseau, Sebastien; Proux, Caroline; Erhardt, Mathieu; Seltzer, Virginie; Renou, Jean-Pierre; Ullmann, Pascaline; Pauly, Markus; Lapierre, Catherine; Werck-Reichhart, Danièle

2006-01-01

Cytochromes P450 monooxygenases from the CYP98 family catalyze the meta-hydroxylation step in the phenylpropanoid biosynthetic pathway. The ref8 Arabidopsis (Arabidopsis thaliana) mutant, with a point mutation in the CYP98A3 gene, was previously described to show developmental defects, changes in lignin composition, and lack of soluble sinapoyl esters. We isolated a T-DNA insertion mutant in CYP98A3 and show that this mutation leads to a more drastic inhibition of plant development and inhibition of cell growth. Similar to the ref8 mutant, the insertion mutant has reduced lignin content, with stem lignin essentially made of p-hydroxyphenyl units and trace amounts of guaiacyl and syringyl units. However, its roots display an ectopic lignification and a substantial proportion of guaiacyl and syringyl units, suggesting the occurrence of an alternative CYP98A3-independent meta-hydroxylation mechanism active mainly in the roots. Relative to the control, mutant plantlets produce very low amounts of sinapoyl esters, but accumulate flavonol glycosides. Reduced cell growth seems correlated with alterations in the abundance of cell wall polysaccharides, in particular decrease in crystalline cellulose, and profound modifications in gene expression and homeostasis reminiscent of a stress response. CYP98A3 thus constitutes a critical bottleneck in the phenylpropanoid pathway and in the synthesis of compounds controlling plant development. CYP98A3 cosuppressed lines show a gradation of developmental defects and changes in lignin content (40% reduction) and structure (prominent frequency of p-hydroxyphenyl units), but content in foliar sinapoyl esters is similar to the control. The purple coloration of their leaves is correlated to the accumulation of sinapoylated anthocyanins. PMID:16377748

Spatially restricted dental regeneration drives pufferfish beak development

PubMed Central

Thiery, Alexandre P.; Shono, Takanori; Kurokawa, Daisuke; Britz, Ralf; Johanson, Zerina

2017-01-01

Vertebrate dentitions are extraordinarily diverse in both morphology and regenerative capacity. The teleost order Tetraodontiformes exhibits an exceptional array of novel dental morphologies, epitomized by constrained beak-like dentitions in several families, i.e., porcupinefishes, three-toothed pufferfishes, ocean sunfishes, and pufferfishes. Modification of tooth replacement within these groups leads to the progressive accumulation of tooth generations, underlying the structure of their beaks. We focus on the dentition of the pufferfish (Tetraodontidae) because of its distinct dental morphology. This complex dentition develops as a result of (i) a reduction in the number of tooth positions from seven to one per quadrant during the transition from first to second tooth generations and (ii) a dramatic shift in tooth morphogenesis following the development of the first-generation teeth, leading to the elongation of dental units along the jaw. Gene expression and 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) lineage tracing reveal a putative dental epithelial progenitor niche, suggesting a highly conserved mechanism for tooth regeneration despite the development of a unique dentition. MicroCT analysis reveals restricted labial openings in the beak, through which the dental epithelium (lamina) invades the cavity of the highly mineralized beak. Reduction in the number of replacement tooth positions coincides with the development of only four labial openings in the pufferfish beak, restricting connection of the oral epithelium to the dental cavity. Our data suggest the spatial restriction of dental regeneration, coupled with the unique extension of the replacement dental units throughout the jaw, are primary contributors to the evolution and development of this unique beak-like dentition. PMID:28507130

Epigenetic Modifications in Essential Hypertension

PubMed Central

Wise, Ingrid A.; Charchar, Fadi J.

2016-01-01

Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world’s leading public health problems. Furthermore, there is increasing evidence that epigenetic modifications are as important as genetic predisposition in the development of EH. Indeed, a complex and interactive genetic and environmental system exists to determine an individual’s risk of EH. Epigenetics refers to all heritable changes to the regulation of gene expression as well as chromatin remodelling, without involvement of nucleotide sequence changes. Epigenetic modification is recognized as an essential process in biology, but is now being investigated for its role in the development of specific pathologic conditions, including EH. Epigenetic research will provide insights into the pathogenesis of blood pressure regulation that cannot be explained by classic Mendelian inheritance. This review concentrates on epigenetic modifications to DNA structure, including the influence of non-coding RNAs on hypertension development. PMID:27023534

Quantifying the thermal heat requirement of Brassica in assessing biophysical parameters under semi-arid microenvironments

NASA Astrophysics Data System (ADS)

Adak, Tarun; Chakravarty, N. V. K.

2010-07-01

Evaluation of the thermal heat requirement of Brassica spp. across agro-ecological regions is required in order to understand the further effects of climate change. Spatio-temporal changes in hydrothermal regimes are likely to affect the physiological growth pattern of the crop, which in turn will affect economic yields and crop quality. Such information is helpful in developing crop simulation models to describe the differential thermal regimes that prevail at different phenophases of the crop. Thus, the current lack of quantitative information on the thermal heat requirement of Brassica crops under debranched microenvironments prompted the present study, which set out to examine the response of biophysical parameters [leaf area index (LAI), dry biomass production, seed yield and oil content] to modified microenvironments. Following 2 years of field experiments on Typic Ustocrepts soils under semi-arid climatic conditions, it was concluded that the Brassica crop is significantly responsive to microenvironment modification. A highly significant and curvilinear relationship was observed between LAI and dry biomass production with accumulated heat units, with thermal accumulation explaining ≥80% of the variation in LAI and dry biomass production. It was further observed that the economic seed yield and oil content, which are a function of the prevailing weather conditions, were significantly responsive to the heat units accumulated from sowing to 50% physiological maturity. Linear regression analysis showed that growing degree days (GDD) could indicate 60-70% variation in seed yield and oil content, probably because of the significant response to differential thermal microenvironments. The present study illustrates the statistically strong and significant response of biophysical parameters of Brassica spp. to microenvironment modification in semi-arid regions of northern India.

Lessons From the Dot Contraceptive Efficacy Study: Analysis of the Use of Agile Development to Improve Recruitment and Enrollment for mHealth Research.

PubMed

Shattuck, Dominick; Haile, Liya T; Simmons, Rebecca G

2018-04-20

Smartphone apps that provide women with information about their daily fertility status during their menstrual cycles can contribute to the contraceptive method mix. However, if these apps claim to help a user prevent pregnancy, they must undergo similar rigorous research required for other contraceptive methods. Georgetown University's Institute for Reproductive Health is conducting a prospective longitudinal efficacy trial on Dot (Dynamic Optimal Timing), an algorithm-based fertility app designed to help women prevent pregnancy. The aim of this paper was to highlight decision points during the recruitment-enrollment process and the effect of modifications on enrollment numbers and demographics. Recruiting eligible research participants for a contraceptive efficacy study and enrolling an adequate number to statistically assess the effectiveness of Dot is critical. Recruiting and enrolling participants for the Dot study involved making decisions based on research and analytic data, constant process modification, and close monitoring and evaluation of the effect of these modifications. Originally, the only option for women to enroll in the study was to do so over the phone with a study representative. On noticing low enrollment numbers, we examined the 7 steps from the time a woman received the recruitment message until she completed enrollment and made modifications accordingly. In modification 1, we added call-back and voicemail procedures to increase the number of completed calls. Modification 2 involved using a chat and instant message (IM) features to facilitate study enrollment. In modification 3, the process was fully automated to allow participants to enroll in the study without the aid of study representatives. After these modifications were implemented, 719 women were enrolled in the study over a 6-month period. The majority of participants (494/719, 68.7%) were enrolled during modification 3, in which they had the option to enroll via phone, chat, or the fully automated process. Overall, 29.2% (210/719) of the participants were enrolled via a phone call, 19.9% (143/719) via chat/IM, and 50.9% (366/719) directly through the fully automated process. With respect to the demographic profile of our study sample, we found a significant statistical difference in education level across all modifications (P<.05) but not in age or race or ethnicity (P>.05). Our findings show that agile and consistent modifications to the recruitment and enrollment process were necessary to yield an appropriate sample size. An automated process resulted in significantly higher enrollment rates than one that required phone interaction with study representatives. Although there were some differences in demographic characteristics of enrollees as the process was modified, in general, our study population is diverse and reflects the overall United States population in terms of race/ethnicity, age, and education. Additional research is proposed to identify how differences in mode of enrollment and demographic characteristics may affect participants' performance in the study. ClinicalTrials.gov NCT02833922; http://clinicaltrials.gov/ct2/show/NCT02833922 (Archived by WebCite at http://www.webcitation.org/6yj5FHrBh). ©Dominick Shattuck, Liya T Haile, Rebecca G Simmons. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 20.04.2018.

The Development of a Design and Construction Process Protocol to Support the Home Modification Process Delivered by Occupational Therapists

PubMed Central

Ormerod, Marcus; Newton, Rita

2018-01-01

Modifying the home environments of older people as they age in place is a well-established health and social care intervention. Using design and construction methods to redress any imbalance caused by the ageing process or disability within the home environment, occupational therapists are seen as the experts in this field of practice. However, the process used by occupational therapists when modifying home environments has been criticised for being disorganised and not founded on theoretical principles and concepts underpinning the profession. To address this issue, research was conducted to develop a design and construction process protocol specifically for home modifications. A three-stage approach was taken for the analysis of qualitative data generated from an online survey, completed by 135 occupational therapists in the UK. Using both the existing occupational therapy intervention process model and the design and construction process protocol as the theoretical frameworks, a 4-phase, 9-subphase design and construction process protocol for home modifications was developed. Overall, the study is innovative in developing the first process protocol for home modifications, potentially providing occupational therapists with a systematic and effective approach to the design and delivery of home modification services for older and disabled people. PMID:29682348

The Development of a Design and Construction Process Protocol to Support the Home Modification Process Delivered by Occupational Therapists.

PubMed

Russell, Rachel; Ormerod, Marcus; Newton, Rita

2018-01-01

Modifying the home environments of older people as they age in place is a well-established health and social care intervention. Using design and construction methods to redress any imbalance caused by the ageing process or disability within the home environment, occupational therapists are seen as the experts in this field of practice. However, the process used by occupational therapists when modifying home environments has been criticised for being disorganised and not founded on theoretical principles and concepts underpinning the profession. To address this issue, research was conducted to develop a design and construction process protocol specifically for home modifications. A three-stage approach was taken for the analysis of qualitative data generated from an online survey, completed by 135 occupational therapists in the UK. Using both the existing occupational therapy intervention process model and the design and construction process protocol as the theoretical frameworks, a 4-phase, 9-subphase design and construction process protocol for home modifications was developed. Overall, the study is innovative in developing the first process protocol for home modifications, potentially providing occupational therapists with a systematic and effective approach to the design and delivery of home modification services for older and disabled people.

Gap model development, validation, and application to succession of secondary subtropical dry forests of Puerto Rico

Treesearch

Jennifer A. Holm; H.H. Shugart; Skip J. Van Bloem; G.R. Larocque

2012-01-01

Because of human pressures, the need to understand and predict the long-term dynamics and development of subtropical dry forests is urgent. Through modifications to the ZELIG simulation model, including the development of species- and site-specific parameters and internal modifications, the capability to model and predict forest change within the 4500-ha Guanica State...

Application Reuse Library for Software, Requirements, and Guidelines

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Thronesbery, Carroll

1994-01-01

Better designs are needed for expert systems and other operations automation software, for more reliable, usable and effective human support. A prototype computer-aided Application Reuse Library shows feasibility of supporting concurrent development and improvement of advanced software by users, analysts, software developers, and human-computer interaction experts. Such a library expedites development of quality software, by providing working, documented examples, which support understanding, modification and reuse of requirements as well as code. It explicitly documents and implicitly embodies design guidelines, standards and conventions. The Application Reuse Library provides application modules with Demo-and-Tester elements. Developers and users can evaluate applicability of a library module and test modifications, by running it interactively. Sub-modules provide application code and displays and controls. The library supports software modification and reuse, by providing alternative versions of application and display functionality. Information about human support and display requirements is provided, so that modifications will conform to guidelines. The library supports entry of new application modules from developers throughout an organization. Example library modules include a timer, some buttons and special fonts, and a real-time data interface program. The library prototype is implemented in the object-oriented G2 environment for developing real-time expert systems.

Inferring nucleosome positions with their histone mark annotation from ChIP data

PubMed Central

Mammana, Alessandro; Vingron, Martin; Chung, Ho-Ryun

2013-01-01

Motivation: The nucleosome is the basic repeating unit of chromatin. It contains two copies each of the four core histones H2A, H2B, H3 and H4 and about 147 bp of DNA. The residues of the histone proteins are subject to numerous post-translational modifications, such as methylation or acetylation. Chromatin immunoprecipitiation followed by sequencing (ChIP-seq) is a technique that provides genome-wide occupancy data of these modified histone proteins, and it requires appropriate computational methods. Results: We present NucHunter, an algorithm that uses the data from ChIP-seq experiments directed against many histone modifications to infer positioned nucleosomes. NucHunter annotates each of these nucleosomes with the intensities of the histone modifications. We demonstrate that these annotations can be used to infer nucleosomal states with distinct correlations to underlying genomic features and chromatin-related processes, such as transcriptional start sites, enhancers, elongation by RNA polymerase II and chromatin-mediated repression. Thus, NucHunter is a versatile tool that can be used to predict positioned nucleosomes from a panel of histone modification ChIP-seq experiments and infer distinct histone modification patterns associated to different chromatin states. Availability: The software is available at http://epigen.molgen.mpg.de/nuchunter/. Contact: chung@molgen.mpg.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23981350

Development Of Simulation Model For Fluid Catalytic Cracking

NASA Astrophysics Data System (ADS)

Ghosh, Sobhan

2010-10-01

Fluid Catalytic Cracking (FCC) is the most widely used secondary conversion process in the refining industry, for producing gasoline, olefins, and middle distillate from heavier petroleum fractions. There are more than 500 units in the world with a total processing capacity of about 17 to 20% of the crude capacity. FCC catalyst is the highest consumed catalyst in the process industry. On one hand, FCC is quite flexible with respect to it's ability to process wide variety of crudes with a flexible product yield pattern, and on the other hand, the interdependence of the major operating parameters makes the process extremely complex. An operating unit is self balancing and some fluctuations in the independent parameters are automatically adjusted by changing the temperatures and flow rates at different sections. However, a good simulation model is very useful to the refiner to get the best out of the process, in terms of selection of the best catalyst, to cope up with the day to day changing of the feed quality and the demands of different products from FCC unit. In addition, a good model is of great help in designing the process units and peripherals. A simple empirical model is often adequate to monitor the day to day operations, but they are not of any use in handling the other problems such as, catalyst selection or, design / modification of the plant. For this, a kinetic based rigorous model is required. Considering the complexity of the process, large number of chemical species undergoing "n" number of parallel and consecutive reactions, it is virtually impossible to develop a simulation model based on the kinetic parameters. The most common approach is to settle for a semi empirical model. We shall take up the key issues for developing a FCC model and the contribution of such models in the optimum operation of the plant.

A study experiment of auto idle application in the excavator engine performance

NASA Astrophysics Data System (ADS)

Purwanto, Wawan; Maksum, Hasan; Putra, Dwi Sudarno; Azmi, Meri; Wahyudi, Retno

2016-03-01

The purpose of this study was to analyze the effect of applying auto idle to excavator engine performance, such as machine unitization and fuel consumption in Excavator. Steps to be done are to modify the system JA 44 and 67 in Vehicle Electronic Control Unit (V-ECU). The modifications will be obtained from the pattern of the engine speed. If the excavator attachment is not operated, the engine speed will return to the idle speed automatically. From the experiment results the auto idle reduces fuel consumption in excavator engine.

A study experiment of auto idle application in the excavator engine performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Purwanto, Wawan, E-mail: wawan5527@gmail.com; Maksum, Hasan; Putra, Dwi Sudarno, E-mail: dwisudarnoputra@ft.unp.ac.id

2016-03-29

The purpose of this study was to analyze the effect of applying auto idle to excavator engine performance, such as machine unitization and fuel consumption in Excavator. Steps to be done are to modify the system JA 44 and 67 in Vehicle Electronic Control Unit (V-ECU). The modifications will be obtained from the pattern of the engine speed. If the excavator attachment is not operated, the engine speed will return to the idle speed automatically. From the experiment results the auto idle reduces fuel consumption in excavator engine.

Polarization-selective transmission in stacked two-dimensional complementary plasmonic crystal slabs

NASA Astrophysics Data System (ADS)

Iwanaga, Masanobu

2010-02-01

It has been experimentally and numerically shown that transmission at near infrared wavelengths is selectively controlled by polarizations in two-dimensional complementary plasmonic crystal slabs (2D c-PlCSs) of stacked unit cell. This feature is naturally derived by taking account of Babinet's principle. Moreover, the slight structural modification of the unit cell has been found to result in a drastic change in linear optical responses of stacked 2D c-PlCSs. These results substantiate the feasibility of 2D c-PlCSs for producing efficient polarizers with subwavelength thickness.

The fretted terrain of the Nilosyrtis Mensae region of Mars: Clues to the timing of dichotomy formation and the emplacement of the northern plains

NASA Technical Reports Server (NTRS)

Detroye, Jeff E.; Williams, Steven H.

1994-01-01

Geologic mapping of the fretted terrain of the Nilosyrtis Mensae region of Mars has revealed geomorphic evidence that the breakup of the plateau units to the south of Nilosyrtis occurred well before the plains units to the north were emplaced in the late Hesperian time. The plains units were deposited against the fretted terrain which has undergone some modification by mass wasting but not significant backwasting. The morphology observed at the contact between plains and the fretted terrain is consistent with that expected where the edge of a pile of sedimentary debris has undergone mass wasting and other erosion.

Preliminary geologic map of the Piru 7.5' quadrangle, southern California: a digital database

USGS Publications Warehouse

Yerkes, R.F.; Campbell, Russell H.

1995-01-01

This Open-File report is a digital geologic map database. This pamphlet serves to introduce and describe the digital data. There is no paper map included in the Open-File report. This digital map database is compiled from previously published sources combined with some new mapping and modifications in nomenclature. The geologic map database delineates map units that are identified by general age and lithology following the stratigraphic nomenclature of the U. S. Geological Survey. For detailed descriptions of the units, their stratigraphic relations and sources of geologic mapping consult Yerkes and Campbell (1995). More specific information about the units may be available in the original sources.

Addendum to the Closure Report for Corrective Action Unit 113: Area 25 R-MAD Facility, Nevada National Security Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

NSTec Environmental Restoration

2011-02-24

This addendum to the Closure Report for Corrective Action Unit 113: Area 25, Reactor Maintenance, Assembly, and Disassembly Facility, Building 3110, Nevada Test Site, Nevada, DOE/NV--891-VOL I-Rev. 1, dated July 2003, provides details of demolition, waste disposal, and use restriction (UR) modification for Corrective Action Unit 113, Area 25 R-MAD Facility. Demolition was completed on July 15, 2010, when the last of the building debris was disposed. Final field activities were concluded on August 30, 2010, after all equipment was demobilized and UR signs were posted. This work was funded by the American Recovery and Reinvestment Act.

Role of Pumped Storage Hydro Resources in Electricity Markets and System Operation: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ela, E.; Kirby, B.; Botterud, A.

2013-05-01

The most common form of utility- sized energy storage system is the pumped storage hydro system. Originally, these types of storage systems were economically viable simply because they displace more expensive generating units. However, over time, as those expensive units became more efficient and costs declined, pumped hydro storage units no longer have the operational edge. As a result, in the current electricity market environment, pumped storage hydro plants are struggling. To offset this phenomenon, certain market modifications should be addressed. This paper will introduce some of the challenges faced by pumped storage hydro plants in today's markets and purposemore » some solutions to those problems.« less

Rapid crop cover mapping for the conterminous United States

USGS Publications Warehouse

Dahal, Devendra; Wylie, Bruce K.; Howard, Daniel

2018-01-01

Timely crop cover maps with sufficient resolution are important components to various environmental planning and research applications. Through the modification and use of a previously developed crop classification model (CCM), which was originally developed to generate historical annual crop cover maps, we hypothesized that such crop cover maps could be generated rapidly during the growing season. Through a process of incrementally removing weekly and monthly independent variables from the CCM and implementing a ‘two model mapping’ approach, we found it viable to generate conterminous United States-wide rapid crop cover maps at a resolution of 250 m for the current year by the month of September. In this approach, we divided the CCM model into one ‘crop type model’ to handle the classification of nine specific crops and a second, binary model to classify the presence or absence of ‘other’ crops. Under the two model mapping approach, the training errors were 0.8% and 1.5% for the crop type and binary model, respectively, while test errors were 5.5% and 6.4%, respectively. With spatial mapping accuracies for annual maps reaching upwards of 70%, this approach demonstrated a strong potential for generating rapid crop cover maps by the 1st of September.

Potential Air Pollutant Emissions and Permitting Classifications for Two Biorefinery Process Designs in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eberle, Annika; Bhatt, Arpit; Zhang, Yimin

Advanced biofuel production facilities (biorefineries), such as those envisioned by the United States (U.S.) Renewable Fuel Standard and U.S. Department of Energy's research and development programs, often lack historical air pollutant emissions data, which can pose challenges for obtaining air emission permits that are required for construction and operation. To help fill this knowledge gap, we perform a thorough regulatory analysis and use engineering process designs to assess the applicability of federal air regulations and quantify air pollutant emissions for two feasibility-level biorefinery designs. We find that without additional emission-control technologies both biorefineries would likely be required to obtain majormore » source permits under the Clean Air Act's New Source Review program. The permitting classification (so-called 'major' or 'minor') has implications for the time and effort required for permitting and therefore affects the cost of capital and the fuel selling price. Consequently, we explore additional technically feasible emission-control technologies and process modifications that have the potential to reduce emissions to achieve a minor source permitting classification. Finally, our analysis of air pollutant emissions and controls can assist biorefinery developers with the air permitting process and inform regulatory agencies about potential permitting pathways for novel biorefinery designs.« less

Potential Air Pollutant Emissions and Permitting Classifications for Two Biorefinery Process Designs in the United States

DOE PAGES

Eberle, Annika; Bhatt, Arpit; Zhang, Yimin; ...

2017-04-26

Advanced biofuel production facilities (biorefineries), such as those envisioned by the United States (U.S.) Renewable Fuel Standard and U.S. Department of Energy's research and development programs, often lack historical air pollutant emissions data, which can pose challenges for obtaining air emission permits that are required for construction and operation. To help fill this knowledge gap, we perform a thorough regulatory analysis and use engineering process designs to assess the applicability of federal air regulations and quantify air pollutant emissions for two feasibility-level biorefinery designs. We find that without additional emission-control technologies both biorefineries would likely be required to obtain majormore » source permits under the Clean Air Act's New Source Review program. The permitting classification (so-called 'major' or 'minor') has implications for the time and effort required for permitting and therefore affects the cost of capital and the fuel selling price. Consequently, we explore additional technically feasible emission-control technologies and process modifications that have the potential to reduce emissions to achieve a minor source permitting classification. Finally, our analysis of air pollutant emissions and controls can assist biorefinery developers with the air permitting process and inform regulatory agencies about potential permitting pathways for novel biorefinery designs.« less

Potential Air Pollutant Emissions and Permitting Classifications for Two Biorefinery Process Designs in the United States.

PubMed

Eberle, Annika; Bhatt, Arpit; Zhang, Yimin; Heath, Garvin

2017-06-06

Advanced biofuel production facilities (biorefineries), such as those envisioned by the United States (U.S.) Renewable Fuel Standard and U.S. Department of Energy's research and development programs, often lack historical air pollutant emissions data, which can pose challenges for obtaining air emission permits that are required for construction and operation. To help fill this knowledge gap, we perform a thorough regulatory analysis and use engineering process designs to assess the applicability of federal air regulations and quantify air pollutant emissions for two feasibility-level biorefinery designs. We find that without additional emission-control technologies both biorefineries would likely be required to obtain major source permits under the Clean Air Act's New Source Review program. The permitting classification (so-called "major" or "minor") has implications for the time and effort required for permitting and therefore affects the cost of capital and the fuel selling price. Consequently, we explore additional technically feasible emission-control technologies and process modifications that have the potential to reduce emissions to achieve a minor source permitting classification. Our analysis of air pollutant emissions and controls can assist biorefinery developers with the air permitting process and inform regulatory agencies about potential permitting pathways for novel biorefinery designs.

Advanced Turbine Technology Applications Project (ATTAP) 1993 annual report

NASA Technical Reports Server (NTRS)

1994-01-01

This report summarizes work performed by AlliedSignal Engines, a unit of AlliedSignal Aerospace Company, during calendar year 1993, toward development and demonstration of structural ceramic technology for automotive gas turbine engines. This work was performed for the U.S. Department of Energy (DOE) under National Aeronautics and Space Administration (NASA) Contract DEN3-335, Advanced Turbine Technology Applications Project (ATFAP). During 1993, the test bed used to demonstrate ceramic technology was changed from the AlliedSignal Engines/Garrett Model AGT101 regenerated gas turbine engine to the Model 331-200(CT) engine. The 331-200(CT) ceramic demonstrator is a fully-developed test platform based on the existing production AlliedSignal 331-200(ER) gas turbine auxiliary power unit (APU), and is well suited to evaluating ceramic turbine blades and nozzles. In addition, commonality of the 331-200(CT) engine with existing gas turbine APU's in commercial service provides the potential for field testing of ceramic components. The 1993 ATTAP activities emphasized design modifications of the 331-200 engine test bed to accommodate ceramic first-stage turbine nozzles and blades, fabrication of the ceramic components, ceramic component proof and rig tests, operational tests of the test bed equipped with the ceramic components, and refinement of critical ceramic design technologies.

Carbon capture test unit design and development using amine-based solid sorbent

DOE Office of Scientific and Technical Information (OSTI.GOV)

Breault, Ronald W.; Spenik, James L.; Shadle, Lawrence J.

This study presents the design and development of a reactor system and the subsequent modifications to evaluate an integrated process to scrub carbon dioxide (CO 2) from synthetic flue gas using amine based solid sorbents. The paper presents the initial system design and then discusses the various changes implemented to address the change in sorbent from a 180 μm Geldart group B material to a 115 μm Geldart group A material as well as issues discovered during experimental trials where the major obstacle in system operation was the ability to maintain a constant circulation of a solid sorbent stemming frommore » this change in sorbent material. The system primarily consisted of four fluid beds, through which an amine impregnated solid sorbent was circulated and adsorption, pre-heat, regeneration, and cooling processes occurred. Instrumentation was assembled to characterize thermal, hydrodynamic, and gas adsorption performance in this integrated unit. A series of shakedown tests were performed and the configuration altered to meet the needs of the sorbent performance and achieve desired target capture efficiencies. Finally, methods were identified, tested, and applied to continuously monitor critical operating parameters including solids circulation rate, adsorbed and desorbed CO 2, solids inventories, and pressures.« less

tRNAmodpred: a computational method for predicting posttranscriptional modifications in tRNAs

PubMed Central

Machnicka, Magdalena A.; Dunin-Horkawicz, Stanislaw; de Crécy-Lagard, Valerie; Bujnicki, Janusz M.

2016-01-01

tRNA molecules contain numerous chemically altered nucleosides, which are formed by enzymatic modification of the primary transcripts during the complex tRNA maturation process. Some of the modifications are introduced by single reactions, while other require complex series of reactions carried out by several different enzymes. The location and distribution of various types of modifications vary greatly between different tRNA molecules, organisms and organelles. We have developed a computational method tRNAmodpred, for predicting modifications in tRNA sequences. Briefly, our method takes as an input one or more unmodified tRNA sequences and a set of protein sequences corresponding to a proteome of a cell. Subsequently it identifies homologs of known tRNA modification enzymes in the proteome, predicts tRNA modification activities and maps them onto known pathways of RNA modification from the MODOMICS database. Thereby, theoretically possible modification pathways are identified, and products of these modification reactions are proposed for query tRNAs. This method allows for predicting modification patterns for newly sequenced genomes as well as for checking tentative modification status of tRNAs from one species treated with enzymes from another source, e.g. to predict the possible modifications of eukaryotic tRNAs expressed in bacteria. tRNAmodpred is freely available as web server at http://genesilico.pl/trnamodpred/. PMID:27016142

Mitochondrial Replacement Techniques, Scientific Tourism, and the Global Politics of Science.

PubMed

Chan, Sarah; Palacios-González, César; De Jesús Medina Arellano, María

2017-09-01

The United Kingdom is the first and so far only country to pass explicit legislation allowing for the licensed use of the new reproductive technology known as mitochondrial replacement therapy. The techniques used in this technology may prevent the transmission of mitochondrial DNA diseases, but they are controversial because they involve the manipulation of oocytes or embryos and the transfer of genetic material. Some commentators have even suggested that MRT constitutes germline genome modification. All eyes were on the United Kingdom as the most likely location for the first MRT birth, so it was a shock when, on September 27, 2016, an announcement went out that the first baby to result from use of the intervention had already been born. In New York City, United States-based scientist John Zhang used maternal spindle transfer (one of the recognized MRT methods) to generate five embryos for a woman carrying oocytes with deleterious mutations of the mitochondrial DNA. Zhang then shipped the only euploid embryo to Mexico, where it was transferred to the mother's uterus. Zhang's team's travel across international borders to carry out experimental procedures represents a form of scientific tourism that has not been properly ethically explored; it can, however, have seriously detrimental effects for developing countries. © 2017 The Hastings Center.

Exercise Countermeasure Hardware Evolution on ISS: The First Decade.

PubMed

Korth, Deborah W

2015-12-01

The hardware systems necessary to support exercise countermeasures to the deconditioning associated with microgravity exposure have evolved and improved significantly during the first decade of the International Space Station (ISS), resulting in both new types of hardware and enhanced performance capabilities for initial hardware items. The original suite of countermeasure hardware supported the first crews to arrive on the ISS and the improved countermeasure system delivered in later missions continues to serve the astronauts today with increased efficacy. Due to aggressive hardware development schedules and constrained budgets, the initial approach was to identify existing spaceflight-certified exercise countermeasure equipment, when available, and modify it for use on the ISS. Program management encouraged the use of commercial-off-the-shelf (COTS) hardware, or hardware previously developed (heritage hardware) for the Space Shuttle Program. However, in many cases the resultant hardware did not meet the additional requirements necessary to support crew health maintenance during long-duration missions (3 to 12 mo) and anticipated future utilization activities in support of biomedical research. Hardware development was further complicated by performance requirements that were not fully defined at the outset and tended to evolve over the course of design and fabrication. Modifications, ranging from simple to extensive, were necessary to meet these evolving requirements in each case where heritage hardware was proposed. Heritage hardware was anticipated to be inherently reliable without the need for extensive ground testing, due to its prior positive history during operational spaceflight utilization. As a result, developmental budgets were typically insufficient and schedules were too constrained to permit long-term evaluation of dedicated ground-test units ("fleet leader" type testing) to identify reliability issues when applied to long-duration use. In most cases, the exercise unit with the most operational history was the unit installed on the ISS.

Wetland survey of the X-10 Bethel Valley and Melton Valley groundwater operable units at Oak Ridge National Labortory Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosensteel, B.A.

1996-03-01

Executive Order 11990, Protection of Wetlands, (May 24, 1977) requires that federal agencies avoid, to the extent possible, adverse impacts associated with the destruction and modification of wetlands and that they avoid direct and indirect support of wetlands development when there is a practicable alternative. In accordance with Department of Energy (DOE) Regulations for Compliance with Floodplains and Wetlands Environmental Review Requirements (Subpart B, 10 CFR 1022.11), surveys for wetland presence or absence were conducted in both the Melton Valley and the Bethel Valley Groundwater Operable Units (GWOU) on the DOE Oak Ridge Reservation (ORR) from October 1994 through Septembermore » 1995. As required by the Energy and Water Development Appropriations Act of 1992, wetlands were identified using the criteria and methods set forth in the Wetlands Delineation Manual (Army Corps of Engineers, 1987). Wetlands were identified during field surveys that examined and documented vegetation, soils, and hydrologic evidence. Most of the wetland boundary locations and wetland sizes are approximate. Boundaries of wetlands in Waste Area Grouping (WAG) 2 and on the former proposed site of the Advanced Neutron Source in the upper Melton Branch watershed were located by civil survey during previous wetland surveys; thus, the boundary locations and areal sizes in these areas are accurate. The wetlands were classified according to the system developed by Cowardin et al. (1979) for wetland and deepwater habitats of the United States. A total of 215 individual wetland areas ranging in size from 0.002 ha to 9.97 ha were identified in the Bethel Valley and Melton Valley GWOUs. The wetlands are classified as palustrine forested broad-leaved deciduous (PFO1), palustrine scrub-shrub broad-leaved deciduous (PSS1), and palustrine persistent emergent (PEM1).« less

Genome-wide identification of sweet orange (Citrus sinensis) histone modification gene families and their expression analysis during the fruit development and fruit-blue mold infection process.

PubMed

Xu, Jidi; Xu, Haidan; Liu, Yuanlong; Wang, Xia; Xu, Qiang; Deng, Xiuxin

2015-01-01

In eukaryotes, histone acetylation and methylation have been known to be involved in regulating diverse developmental processes and plant defense. These histone modification events are controlled by a series of histone modification gene families. To date, there is no study regarding genome-wide characterization of histone modification related genes in citrus species. Based on the two recent sequenced sweet orange genome databases, a total of 136 CsHMs (Citrus sinensis histone modification genes), including 47 CsHMTs (histone methyltransferase genes), 23 CsHDMs (histone demethylase genes), 50 CsHATs (histone acetyltransferase genes), and 16 CsHDACs (histone deacetylase genes) were identified. These genes were categorized to 11 gene families. A comprehensive analysis of these 11 gene families was performed with chromosome locations, phylogenetic comparison, gene structures, and conserved domain compositions of proteins. In order to gain an insight into the potential roles of these genes in citrus fruit development, 42 CsHMs with high mRNA abundance in fruit tissues were selected to further analyze their expression profiles at six stages of fruit development. Interestingly, a numbers of genes were expressed highly in flesh of ripening fruit and some of them showed the increasing expression levels along with the fruit development. Furthermore, we analyzed the expression patterns of all 136 CsHMs response to the infection of blue mold (Penicillium digitatum), which is the most devastating pathogen in citrus post-harvest process. The results indicated that 20 of them showed the strong alterations of their expression levels during the fruit-pathogen infection. In conclusion, this study presents a comprehensive analysis of the histone modification gene families in sweet orange and further elucidates their behaviors during the fruit development and the blue mold infection responses.

Environmental factors that influence the location of crop agriculture in the conterminous United States

USGS Publications Warehouse

Baker, Nancy T.; Capel, Paul D.

2011-01-01

Most crops are grown on land with shallow slope where the temperature, precipitation, and soils are favorable. In areas that are too steep, wet, or dry, landscapes have been modified to allow cultivation. Some of the limitations of the environmental factors that determine the location of agriculture can be overcome through modifications, but others cannot. On a larger-than-field scale, agricultural modifications commonly influence water availability through irrigation and (or) drainage and soil fertility and (or) organic-matter content through amendments such as manure, commercial fertilizer and lime. In general, it is not feasible to modify the other environmental factors, soil texture, soil depth, soil mineralogy, temperature, and terrain at large scales.

Computer program for computing the properties of seventeen fluids. [cryogenic liquids

NASA Technical Reports Server (NTRS)

Brennan, J. A.; Friend, D. G.; Arp, V. D.; Mccarty, R. D.

1992-01-01

The present study describes modifications and additions to the MIPROPS computer program for calculating the thermophysical properties of 17 fluids. These changes include adding new fluids, new properties, and a new interface to the program. The new program allows the user to select the input and output parameters and the units to be displayed for each parameter. Fluids added to the MIPROPS program are carbon dioxide, carbon monoxide, deuterium, helium, normal hydrogen, and xenon. The most recent modifications to the MIPROPS program are the addition of viscosity and thermal conductivity correlations for parahydrogen and the addition of the fluids normal hydrogen and xenon. The recently added interface considerably increases the program's utility.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitledge, T.E.; Malloy, S.C.; Patton, C.J.

This manual was assembled for use as a guide for analyzing the nutrient content of seawater samples collected in the marine coastal zone of the Northeast United States and the Bering Sea. Some modifications (changes in dilution or sample pump tube sizes) may be necessary to achieve optimum measurements in very pronounced oligotrophic, eutrophic or brackish areas. Information is presented under the following section headings: theory and mechanics of automated analysis; continuous flow system description; operation of autoanalyzer system; cookbook of current nutrient methods; automated analyzer and data analysis software; computer interfacing and hardware modifications; and trouble shooting. The threemore » appendixes are entitled: references and additional reading; manifold components and chemicals; and software listings. (JGB)« less

Can environmental purchasing reduce mercury in U.S. health care?

PubMed Central

Eagan, Patrick D; Kaiser, Barb

2002-01-01

Environmental purchasing represents an innovative approach to mercury control for the health care sector in the United States. The U.S. health care sector creates significant environmental impacts, including the release of toxic substances such as mercury. Our goal in this study was to provide the health care industry with a method of identifying the environmental impacts associated with the products they use. The Health Care Environmental Purchasing Tool (HCEPT) was developed and tested at nine health care facilities in the Great Lakes region of the United States. As a result, more than 1 kg of mercury was removed from four facilities. The complexity of the supply chain inhibits a direct environmental information exchange between health-care decision makers and suppliers. However, a dialogue is starting within the health care supply chain to address environmental issues. The HCEPT has been shown to assist health care facilities with that dialogue by identifying products that have environmental consequences. This promising tool is now available for further experimentation and modification, to facilitate overall environmental improvement, and to provide a systematic method for environmental assessment of health care products. PMID:12204816

Mood and anxiety problems in perinatal Indigenous women in Australia, New Zealand, Canada, and the United States: a critical review of the literature.

PubMed

Bowen, Angela; Duncan, Vicky; Peacock, Shelley; Bowen, Rudy; Schwartz, Laura; Campbell, Diane; Muhajarine, Nazeem

2014-02-01

We conducted a review of research literature related to anxiety, depression, and mood problems in Indigenous women in Canada, the United States (including Hawaii), Australia, and New Zealand. Quantitative and qualitative research studies published between 1980 and March 2010 were reviewed. The initial search revealed 396 potential documents, and after being checked for relevance by two researchers, data were extracted from 16 quantitative studies, one qualitative research article, and one dissertation. Depression is a common problem in Indigenous pregnant and postpartum women; however, the prevalence and correlates of anxiety and mood disorders are understudied. The review identified four key areas where further research is needed: (a) longitudinal, population-based studies; (b) further validation and modification of appropriate screening tools; (c) exploration of cultural diversity and meaning of the lived experiences of antenatal and postpartum depression, anxiety, and mood disorders; and (d) development of evidence-informed practices for researchers and practitioners through collaborations with Aboriginal communities to better understand and improve mental health of women of childbearing age.

DON modification in naturally-contaminated wheat samples using microorganisms isolated from the environment

USDA-ARS?s Scientific Manuscript database

The fungus Fusarium graminearum produces the toxic compound deoxynivalenol (DON) that contaminates wheat, barley, and maize. New strategies are needed to mitigate DON in the United States. Microbes were isolated from different soil types, and cultured in a mineral salt media using 100 ppm DON as the...

Modifying Exposure-Based CBT for Cambodian Refugees with Posttraumatic Stress Disorder

ERIC Educational Resources Information Center

Otto, Michael W.; Hinton, Devon E.

2006-01-01

Cambodian refugees represent a severely traumatized population living in the United States. In this paper, we describe the modification of a cognitive-behavior therapy program to facilitate delivery of an exposure-based treatment for posttraumatic stress disorder while addressing some of the challenges brought by differences in language and…

Streamflow Modification Through Management of Eastern Forests

Treesearch

James E. Douglass; Wayne T. Swank

1972-01-01

Protection of the water resource was a primary objective in establishing the National Forest System in America, and improving quantity, quality, and timing of streamflow is an important objective of forest management in certain regions of the United States.Effective management of the forest for increased streamflow presupposes that impact of various management...

19 CFR 181.100 - Effect of NAFTA advance ruling letters; modification and revocation.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., may be applied to entries for consumption and warehouse withdrawals for consumption which are... qualifies for duty-free treatment under § 181.64 of this part when the good re-enters the United States... be applied to entries or warehouse withdrawals for consumption which were made prior to the effective...

19 CFR 181.100 - Effect of NAFTA advance ruling letters; modification and revocation.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., may be applied to entries for consumption and warehouse withdrawals for consumption which are... qualifies for duty-free treatment under § 181.64 of this part when the good re-enters the United States... be applied to entries or warehouse withdrawals for consumption which were made prior to the effective...

19 CFR 181.100 - Effect of NAFTA advance ruling letters; modification and revocation.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., may be applied to entries for consumption and warehouse withdrawals for consumption which are... qualifies for duty-free treatment under § 181.64 of this part when the good re-enters the United States... be applied to entries or warehouse withdrawals for consumption which were made prior to the effective...

BOILER DESIGN CRITERIA FOR DRY SORBENT SO2 CONTROL WITH LOW-NOX BURNERS: NEW UNIT APPLICATIONS

EPA Science Inventory

The report describes a study to define boiler modifications required to achieve 70% SO2 removal with sorbent injection on a large tangentially fired utility boiler without supplemental spray drying. The study is a follow on to a recently completed broader evaluation of boiler des...

Adaptations for English Language Learners: Differentiating between Linguistic and Instructional Accommodations

ERIC Educational Resources Information Center

Pappamihiel, N. Eleni; Lynn, C. Allen

2016-01-01

While many teachers and teacher educators in the United States K-12 system acknowledge that the English language learners (ELLs) in our schools need modifications and accommodations to help them succeed in school, few attempt to parse out how different types of accommodations may affect learning in the mainstream classroom, specifically linguistic…

262. Photocopy of drawing (1976 piping drawing by StearnsRoger Incorporated) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

262. Photocopy of drawing (1976 piping drawing by Stearns-Roger Incorporated) GLOBAL POSITIONING SYSTEM MODIFICATIONS, PAYLOAD PRESSURIZATION UNIT HIGH PRESSURE GASEOUS NITROGEN AND HELIUM LINES FOR LSB, SHEET 501-P3 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Identification of ICD Codes Suggestive of Child Maltreatment

ERIC Educational Resources Information Center

Schnitzer, Patricia G.; Slusher, Paula L.; Kruse, Robin L.; Tarleton, Molly M.

2011-01-01

Objective: In order to be reimbursed for the care they provide, hospitals in the United States are required to use a standard system to code all discharge diagnoses: the International Classification of Disease, 9th Revision, Clinical Modification (ICD-9). Although ICD-9 codes specific for child maltreatment exist, they do not identify all…

77 FR 51853 - Fisheries of the Northeastern United States; Atlantic Mackerel, Squid, and Butterfish Fisheries...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... rule. SUMMARY: NMFS is modifying the Mid-Atlantic Fishery Management Council's risk policy regarding... Management Council in order to clarify its tolerance for risk for such stocks. The modification will allow... 648.20) and a risk policy (Sec. 648.21) to guide the Council's Scientific and Statistical Committee...

SEVENTH GRADE MATHEMATICS FOR THE ACADEMICALLY TALENTED, TEACHERS' GUIDE.

ERIC Educational Resources Information Center

HORN, R.A.

MATERIALS FOR BOTH ENRICHED AND ACCELERATED MATHEMATICS COURSES ARE GIVEN. THE PRESENTATION OF THE MATERIALS IS INTENDED FOR EASY ADAPTATION OF MODIFICATION TO MEET THE NEEDS OF MOST MATHEMATICS CLASSES. SUGGESTIONS AND SUPPLEMENTARY REFERENCES IN EACH UNIT ARE OFFERED AS AIDS TO THE MATHEMATICS TEACHER IN REGULAR OR ACCELERATED CLASS. UNITS…