Sample records for dhs workshop

  1. 75 FR 28051 - Public Workshop: Pieces of Privacy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary Public Workshop: Pieces of Privacy AGENCY: Privacy Office, DHS. ACTION: Notice announcing public workshop. SUMMARY: The Department of Homeland Security Privacy Office will host a public workshop, ``Pieces of Privacy.'' DATES: The workshop will be...

  2. 75 FR 8099 - Public Workshop on Marine Technology and Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Technology and Standards AGENCY: Coast Guard, DHS. ACTION: Notice. SUMMARY: The American Society of...-day public workshop in Washington DC on marine technology and standards. This public workshop will provide a unique opportunity for classification societies, industry groups, standards development...

  3. 78 FR 23574 - Public Workshop on Marine Technology and Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... Technology and Standards AGENCY: Coast Guard, DHS. ACTION: Notice. SUMMARY: The American Society of... workshop on marine technology and standards in Arlington, VA. We originally published a notice regarding... Engineers/United States Coast Guard (ASME/USCG) Workshop on Marine Technology and Standards provides a...

  4. Computer Simulation for Emergency Incident Management

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brown, D L

    2004-12-03

    This report describes the findings and recommendations resulting from the Department of Homeland Security (DHS) Incident Management Simulation Workshop held by the DHS Advanced Scientific Computing Program in May 2004. This workshop brought senior representatives of the emergency response and incident-management communities together with modeling and simulation technologists from Department of Energy laboratories. The workshop provided an opportunity for incident responders to describe the nature and substance of the primary personnel roles in an incident response, to identify current and anticipated roles of modeling and simulation in support of incident response, and to begin a dialog between the incident responsemore » and simulation technology communities that will guide and inform planned modeling and simulation development for incident response. This report provides a summary of the discussions at the workshop as well as a summary of simulation capabilities that are relevant to incident-management training, and recommendations for the use of simulation in both incident management and in incident management training, based on the discussions at the workshop. In addition, the report discusses areas where further research and development will be required to support future needs in this area.« less

  5. Cyber Mutual Assistance Workshop Report

    DTIC Science & Technology

    2018-02-01

    Information Technology, Nuclear Reactors, Materials/Waste, Defense Industrial Base, Critical Manufacturing, Food/ Agriculture Government Facilities and...Manufacturing, Food/ Agriculture Government Facilities and Chemical, Commercial Facilities [DHS 2017c]. Distributed Energy Resources (DER) are

  6. The future of infrastructure security :

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garcia, Pablo; Turnley, Jessica Glicken; Parrott, Lori K.

    2013-05-01

    Sandia National Laboratories hosted a workshop on the future of infrastructure security on February 27-28, 2013, in Albuquerque, NM. The 17 participants came from backgrounds as diverse as federal policy, the insurance industry, infrastructure management, and technology development. The purpose of the workshop was to surface key issues, identify directions forward, and lay groundwork for cross-sectoral and cross-disciplinary collaborations. The workshop addressed issues such as the problem space (what is included in infrastructure problems?), the general types of threats to infrastructure (such as acute or chronic, system-inherent or exogenously imposed) and definitions of secure and resilient infrastructures. The workshop concludedmore » with a consideration of stakeholders and players in the infrastructure world, and identification of specific activities that could be undertaken by the Department of Homeland Security (DHS) and other players.« less

  7. International Scavenging for First Responder Guidance and Tools: IAEA Products

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stern, W.; Berthelot, L.; Bachner, K.

    In fiscal years (FY) 2016 and 2017, with support from the U.S. Department of Homeland Security (DHS), Brookhaven National Laboratory (BNL) examined the International Atomic Energy Agency (IAEA) radiological emergency response and preparedness products (guidance and tools) to determine which of these products could be useful to U.S. first responders. The IAEA Incident and Emergency Centre (IEC), which is responsible for emergency preparedness and response, offers a range of tools and guidance documents for responders in recognizing, responding to, and recovering from radiation emergencies and incidents. In order to implement this project, BNL obtained all potentially relevant tools and productsmore » produced by the IAEA IEC and analyzed these materials to determine their relevance to first responders in the U.S. Subsequently, BNL organized and hosted a workshop at DHS National Urban Security Technology Laboratory (NUSTL) for U.S. first responders to examine and evaluate IAEA products to consider their applicability to the United States. This report documents and describes the First Responder Product Evaluation Workshop, and provides recommendations on potential steps the U.S. federal government could take to make IAEA guidance and tools useful to U.S. responders.« less

  8. Contribution of Asteroid Generated Tsunami to the Impact Hazard

    NASA Technical Reports Server (NTRS)

    Morrison, David; Venkatapathy, Ethiraj

    2017-01-01

    The long-standing uncertainty about the importance of asteroid-generated tsunami was addressed at a workshop in August 2016, co-sponsored by NASA and NOAA. Experts from NASA, NOAA, the DoE tri-labs (LLNL, SNL, and LANL), DHS, FEMA, and academia addressed the hazard of tsunami created by asteroid impacts, focusing primarily on NEAs with diameter less than 250m. Participants jointly identified key issues and shared information for nearly a year to coordinate their results for discussion at the workshop. They used modern computational tools to examine 1) Near-field wave generation by the impact; 2) Long-distance wave propagation; 3) Damage from coastal run-up and inundation, and associated hazard. The workshop resulted in broad consensus that the asteroid impact tsunami threat is not as great as previously thought.

  9. Augmented reality fluoroscopy simulation of the guide-wire insertion in DHS surgery: A proof of concept study.

    PubMed

    van Duren, B H; Sugand, K; Wescott, R; Carrington, R; Hart, A

    2018-05-01

    Hip fractures contribute to a significant clinical burden globally with over 1.6 million cases per annum and up to 30% mortality rate within the first year. Insertion of a dynamic hip screw (DHS) is a frequently performed procedure to treat extracapsular neck of femur fractures. Poorly performed DHS fixation of extracapsular neck of femur fractures can result in poor mobilisation, chronic pain, and increased cut-out rate requiring revision surgery. A realistic, affordable, and portable fluoroscopic simulation system can improve performance metrics in trainees, including the tip-apex distance (the only clinically validated outcome), and improve outcomes. We developed a digital fluoroscopic imaging simulator using orthogonal cameras to track coloured markers attached to the guide-wire which created a virtual overlay on fluoroscopic images of the hip. To test the accuracy with which the augmented reality system could track a guide-wire, a standard workshop femur was used to calibrate the system with a positional marker fixed to indicate the apex; this allowed for comparison between guide-wire tip-apex distance (TAD) calculated by the system to be compared to that physically measured. Tests were undertaken to determine: (1) how well the apex could be targeted; (2) the accuracy of the calculated TAD. (3) The number of iterations through the algorithm giving the optimal accuracy-time relationship. The calculated TAD was found to have an average root mean square error of 4.2 mm. The accuracy of the algorithm was shown to increase with the number of iterations up to 20 beyond which the error asymptotically converged to an error of 2 mm. This work demonstrates a novel augmented reality simulation of guide-wire insertion in DHS surgery. To our knowledge this has not been previously achieved. In contrast to virtual reality, augmented reality is able to simulate fluoroscopy while allowing the trainee to interact with real instrumentation and performing the procedure on workshop bone models. Copyright © 2018 IPEM. Published by Elsevier Ltd. All rights reserved.

  10. 75 FR 52769 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... Committee meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on September 28, 2010, in Washington, DC. The meeting will be open to the public. DATES: The DHS Data Privacy and... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2010-0060] DHS Data...

  11. 75 FR 8087 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on March 18, 2010, in Washington, DC. The meeting will be open to the public. DATES: The DHS Data Privacy and... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2010-0009] DHS Data...

  12. 77 FR 37061 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2012-0014] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on July 17, 2012, in Washington, DC. The meeting will be open to the public. DATES: The DHS...

  13. 76 FR 58524 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0076] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on October 5, 2011, in Arlington, VA. The meeting will be open to the public. DATES: The DHS...

  14. 76 FR 25361 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0022] DHS Data... of Federal Advisory Committee Meeting SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet by teleconference on May 19, 2011. The meeting will be open to the public. DATES: The DHS...

  15. 75 FR 25870 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... Federal Advisory Committee meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on May 25, 2010, in Washington, DC. The meeting will be open to the public. DATES: The DHS Data... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2010-0035] DHS Data...

  16. 76 FR 35459 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0046] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on July 11, 2011, in Washington, DC. The meeting will be open to the public. DATES: The DHS...

  17. 78 FR 7440 - Agency Information Collection Activities: Submission for Review; Information Collection Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... (DHS Form 10008); (9) Application for SAFETY Act Certification (DHS Form 10007); (10) SAFETY Act Block Designation Application (DHS Form 10005); and (11) SAFETY Act Block Certification Application (DHS Form 10004... distribution chain. The Department of Homeland Security Science & Technology Directorate (DHS S&T) currently...

  18. 76 FR 8754 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... Committee meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on March 9, 2011, in Washington, DC. The meeting will be open to the public. DATES: The DHS Data Privacy and Integrity... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0001] DHS Data...

  19. 76 FR 10385 - Agency Information Collection Activities: Various Contract Related Forms That Will be Included in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Forms That Will be Included in the Homeland Security Acquisition Regulation, DHS FORM 0700-01, DHS FORM 0700-02, DHS FORM 0700-03, DHS FORM 0700-04 AGENCY: Office of Chief Procurement Officer, Acquisition..., Acquisition Policy and Legislation Office, DHS will submit the following information collection request (ICR...

  20. One-electron redox processes in a cyclic selenide and a selenoxide: a pulse radiolysis study.

    PubMed

    Singh, Beena G; Thomas, Elizabeth; Kumakura, Fumio; Dedachi, Kenichi; Iwaoka, Michio; Priyadarsini, K Indira

    2010-08-19

    One-electron redox reactions of cyclic selenium compounds, DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)), and DL-trans-3,4-dihydroxy-1-selenolane oxide (DHS(ox)) were carried out in aqueous solutions using nanosecond pulse radiolysis, and the resultant transients were detected by absorption spectroscopy. Both *OH radical and specific one-electron oxidant, Br(2)(*-) radical reacted with DHS(red) to form similar transients absorbing at 480 nm, which has been identified as a dimer radical cation (DHS(red))(2)(*+). Secondary electron transfer reactions of the (DHS(red))(2)(*+) were studied with 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(2-)) and superoxide (O(2)(*-)) radicals. The bimolecular rate constants for the electron transfer reaction between (DHS(red))(2)(*+) with ABTS(2-) was determined as 2.4 +/- 0.4 x 10(9) M(-1) s(-1). From this reaction, the yield of (DHS(red))(2)(*+) formed on reaction with *OH radical was estimated in the presence of varying phosphate concentrations. (DHS(red))(2)(*+) reacted with O(2)(*-) radical with a bimolecular rate constant of 2.7 +/- 0.1 x 10(9) M(-1) s(-1) at pH 7. From the same reaction, the positive charge on (DHS(red))(2)(*+) was confirmed by the kinetic salt effect. HPLC analysis of the products formed in the reaction of (DHS(red))(2)(*+) with O(2)(*-) radicals showed formation of the selenoxide, DHS(ox). In order to know if a similar mechanism operated during the reduction of DHS(ox), its reactions with e(aq)(-) were studied at pH 7. The rate constant for this reaction was determined as 5.6 +/- 0.9 x 10(9) M(-1) s(-1), and no transient absorption could be observed in the wavelength region from 280 to 700 nm. It is proposed that the radical anion (DHS(ox))(*-) formed by a one-electron reduction would get protonated to form a hydroxyl radical adduct, which in presence of proton donors, would undergo dehydration to form DHS(*+). Evidence for this mechanism was obtained by converting DHS(*+) to (DHS(red))(2)(*+) with the addition of DHS(red) to the same system. Quantum chemical calculations provided supporting evidence for some of the redox reactions.

  1. 77 FR 32655 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... Officer, Data Privacy and Integrity Advisory Committee, Department of Homeland Security, 245 Murray Lane..., DHS Data Privacy and Integrity Advisory Committee, Department of Homeland Security, 245 Murray Lane SW... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2012-0029] DHS Data...

  2. Job satisfaction and job content in Dutch dental hygienists.

    PubMed

    Jerković-Ćosić, K; van Offenbeek, M A G; van der Schans, C P

    2012-08-01

    This study compares the scope of practice of Dutch dental hygienists (DHs) educated through a 2- or 3-year curriculum ('old-style DHs') with that of hygienists educated through a new extended 4-year curriculum leading to a bachelor's degree ('new-style DHs'), with the aim to investigate whether an extended scope of practice positively affects perceived skill variety, autonomy and job satisfaction. The questionnaires were obtained from old- and new-style DHs (n = 413, response 38%; n = 219, response 59%, respectively), in which respondents had recorded their dental tasks, perceived skill variety, autonomy and job satisfaction. T -tests were used to analyse differences between old- and new-style DHs, and regression analyses were performed to assess the relation between scope of practice and skill variety, autonomy and job satisfaction. New-style DHs have a more extended scope of practice compared with old-style DHs. Despite their more complex jobs, which are theoretically related to higher job satisfaction, new-style DHs perceive lower autonomy and job satisfaction (P < 0.05). Skill variety is the strongest predictor for DHs' job satisfaction (β = 0.462), followed by autonomy (β = 0.202) and caries decisive tasks, the last affecting job satisfaction negatively (β = -0.149). Self-employment is the strongest significant predictor for autonomy (β = 0.272). The core business of DHs remains the prevention and periodontology services. New-style DHs combine these tasks with extended tasks in the caries field, which can lead to comparatively less job satisfaction, because of a lower experienced autonomy in performing these extended tasks. © 2012 John Wiley & Sons A/S.

  3. 78 FR 51197 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2013-0055] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on September 12, 2013, in Washington, DC. The meeting will be open to the public. DATES: The...

  4. 77 FR 60131 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2012-0052] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on November 7, 2012, in Washington, DC. The meeting will be open to the public. DATES: The...

  5. 76 FR 70464 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0105] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on December 6, 2011, in Washington, DC. The meeting will be open to the public. DATES: The...

  6. 78 FR 75930 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-13

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2013-0080] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on January 30, 2014, in Washington, DC. The meeting will be open to the public. DATES: The...

  7. 77 FR 60130 - Agency Information Collection Activities: Submission for Review; Information Collection Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... SAFETY Act Certification (DHS Form 10007); (10) SAFETY Act Block Designation Application (DHS Form 10005); and (11) SAFETY Act Block Certification Application (DHS Form 10004). DATES: Comments are encouraged... chain. The Department of Homeland Security Science & Technology Directorate (DHS S&T) currently has...

  8. 76 FR 11254 - Submission for Review; Information Collection Extension Request for the DHS S&T First Responders...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0008] Submission for Review; Information... Homeland Security (DHS) invites the general public to comment on the data collection form for the DHS... select authorized non-first responder users to facilitate networking and formation of online communities...

  9. 76 FR 61725 - Agency Information Collection Activities: Case Submission Form, Case Assistance Form; (Form DHS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ..., Case Assistance Form; (Form DHS-7001), Online Ombudsman Form DHS-7001 AGENCY: Office of the Citizenship... System'' to ``Online Ombudsman Form DHS-7001''. The instructions have been updated to reflect the... Services Ombudsman--001 Virtual Ombudsman System (March 2010) to reflect the name change to Online...

  10. Wing-augmentation reduces femoral head cutting out of dynamic hip screw.

    PubMed

    Chen, Chih-Yu; Huang, Shu-Wei; Sun, Jui-Sheng; Lin, Shin-Yiing; Yu, Chih-Sheng; Pan, Hsu-Pin; Lin, Ping-Hung; Hsieh, Fan-Chun; Tsuang, Yang-Hwei; Lin, Feng-Huei; Yang, Rong-Sen; Cheng, Cheng-Kung

    2017-06-01

    The dynamic hip screw (DHS) is commonly used in the treatment of femoral intertrochanteric fracture with high satisfactory results. However, post-operative failure does occur and result in poor prognosis. The most common failure is femoral head varus collapse, followed by lag screw cut-out through the femoral head. In this study, a novel-designed DHS with two supplemental horizontal blades was used to improve the fixation stability. In this study, nine convention DHS and 9 Orthopaedic Device Research Center (ODRC) DHSs were tested in this study. Each implant was fixed into cellular polyurethane rigid foam as a surrogate of osteoporotic femoral head. Under biaxial rocking motion, all constructs were loaded to failure point (12mm axial displacement) or up to 20,000 cycles of 1.45kN peak magnitude were achieved, whichever occurred first. The migration kinematics was continuously monitored and recorded. The final tip-to-apex distance, rotational angle and varus deformation were also recorded. The results showed that the ODRC DHS sustained significantly more loading cycles and exhibited less axial migration in comparison to the conventional DHS. The ODRC DHS showed a significantly smaller bending strain and larger torsional strain compared to the conventional DHS. The changes in tip-to-apex distance (TAD), post-study varus angle, post-study rotational angle of the ODRC DHS were all significantly less than that of the conventional DHS (p < 0.05). We concluded that the ODRC DHS augmented with two horizontal wings would increase the bone-implant interface contact surface, dissipate the load to the screw itself, which improves the migration resistance and increases the anti-rotational implant effect. In conclusion, the proposed ODRC DHS demonstrated significantly better migration resistance and anti-rotational effect in comparison to the conventional DHS construct. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

  11. 75 FR 69688 - Agency Information Collection Activities: Various Contract Related Forms That Will Be Included in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ... Forms That Will Be Included in the Homeland Security Acquisition Regulation, DHS Form 0700-01, DHS Form 0700-02, DHS Form 0700-03, DHS FORM 0700-04 AGENCY: Office of Chief Procurement Officer, Acquisition..., Acquisition Policy and Legislation Office, will submit the following Information Collection Request (ICR) to...

  12. 8 CFR 208.5 - Special duties toward aliens in custody of DHS.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Special duties toward aliens in custody of DHS. 208.5 Section 208.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION... duties toward aliens in custody of DHS. (a) General. When an alien in the custody of DHS requests asylum...

  13. 20 CFR 655.855 - What notice shall be given to the Employment and Training Administration and the DHS of the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and the DHS of the decision regarding violations? (a) The Administrator shall notify the DHS and ETA... notify the DHS and ETA upon the earliest of the following events: (1) Where the Administrator determines....810(f). (d) ETA, upon receipt of the Administrator's notice pursuant to paragraph (a) of this section...

  14. Severe pain as a possible cause of dropped head syndrome that was attenuated after amputation of an ischemic lower limb.

    PubMed

    Maki, Satoshi; Koda, Masao; Furuya, Takeo; Takahashi, Kazuhisa; Yamazaki, Masashi

    2016-03-02

    Dropped head syndrome (DHS) is defined as weakness of the neck extensor muscles causing a correctable chin-on-the-chest deformity. Here we report the case of a patient with severe pain from lower leg ischemia showing DHS whose symptoms were attenuated by pain relief after amputation of the severely ischemic lower leg. To our knowledge this is the first report indicating that severe pain can cause DHS. A 64-year-old Asian woman was referred to our department with a 1-month history of DHS. She also suffered from severe right foot pain because of limb ischemia. She began to complain of DHS as her gangrenous foot pain worsened. She had neck pain and difficulty with forward gaze. We found no clinical or laboratory findings of neuromuscular disorder or isolated neck extensor myopathy. We amputated her leg below the knee because of progressive foot gangrene. Her severe foot pain resolved after the surgery and her DHS was attenuated. Severe pain can cause DHS. If a patient with DHS has severe pain in another part of the body, we recommend considering aggressive pain relief as a treatment option.

  15. 48 CFR 3052.219-71 - DHS mentor-protégé program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false DHS mentor-protégÃ... CONTRACT CLAUSES Text of Provisions and Clauses 3052.219-71 DHS mentor-protégé program. As prescribed in (HSAR) 48 CFR 3019.708-70(b), insert the following clause: DHS Mentor-Protégé Program (JUN 2006) (a...

  16. 6 CFR Appendix C to Part 5 - DHS Systems of Records Exempt From the Privacy Act

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DISCLOSURE OF RECORDS AND INFORMATION Pt. 5, App. C Appendix C to Part 5—DHS Systems of Records Exempt From... Homeland Security (DHS) Freedom of Information Act (FOIA) and Privacy Act (PA) Record System allows the DHS... information contained in other systems of records subject to such exemptions pursuant to 5 U.S.C. 552a(j)(2...

  17. Bifunctional activity of deoxyhypusine synthase/hydroxylase from Trichomonas vaginalis.

    PubMed

    Quintas-Granados, Laura Itzel; Carvajal Gamez, Bertha Isabel; Villalpando, Jose Luis; Ortega-Lopez, Jaime; Arroyo, Rossana; Azuara-Liceaga, Elisa; Álvarez-Sánchez, María Elizbeth

    2016-04-01

    The Trichomonas vaginalis genome analysis suggested the presence of a putative deoxyhypusine synthase (TvDHS) that catalyzes the posttranslational modification of eIF-5A. Herein, we expressed and purified the recombinant TvDHS (rTvDHS) protein (43 kDa) and the recombinant TveIF-5A (rTveIF-5A) precursor protein (46 kDa). A 41 kDa band of the native TvDHS was recognized by western blot analysis in T. vaginalis total protein extract by a mouse polyclonal anti-rTvDHS antibody. The enzymatic activity of rTvDHS was determined by in vitro rTveIF-5A precursor modification. The modification reaction was performed by using ((3)H)-spermidine, and the biochemical analysis showed that rTvDHS exhibited Km value of 0.6 μM. The rTvDHS activity was inhibited by the spermidine analog, N″-guanyl-1,7-diamino-heptane (GC7). Native gel electrophoresis analysis showed two bands corresponding to an rTvDHS-rTveIF-5A complex and an intermediate form of rTveIF-5A. The two forms were subsequently separated by ion exchange chromatography to identify the hypusine residue by MS/MS analysis. Moreover, mutations in TvDHS showed that the putative HE motif present in this enzyme is involved in the hydroxylation of TveIF-5A. We observed that only hypusine-containing TveIF-5A was bound to an RNA hairpin ERE structure from the cox-2 gene, which contains the AAAUGUCACAC consensus sequence. Interestingly, 2DE-WB assays, using parasites that were grown in DAB-culture conditions and transferred to exogenous putrescine, showed the new isoform of TveIF-5A. In summary, our results indicate that T. vaginalis contains an active TvDHS capable of modifying the precursor TveIF-5A protein, which subsequently exhibits RNA binding activity. Copyright © 2015. Published by Elsevier B.V.

  18. Dynamic Fluid Flow Mechanical Stimulation Modulates Bone Marrow Mesenchymal Stem Cells.

    PubMed

    Hu, Minyi; Yeh, Robbin; Lien, Michelle; Teeratananon, Morgan; Agarwal, Kunal; Qin, Yi-Xian

    2013-03-01

    Osteoblasts are derived from mesenchymal stem cells (MSCs), which initiate and regulate bone formation. New strategies for osteoporosis treatments have aimed to control the fate of MSCs. While functional disuse decreases MSC growth and osteogenic potentials, mechanical signals enhance MSC quantity and bias their differentiation toward osteoblastogenesis. Through a non-invasive dynamic hydraulic stimulation (DHS), we have found that DHS can mitigate trabecular bone loss in a functional disuse model via rat hindlimb suspension (HLS). To further elucidate the downstream cellular effect of DHS and its potential mechanism underlying the bone quality enhancement, a longitudinal in vivo study was designed to evaluate the MSC populations in response to DHS over 3, 7, 14, and 21 days. Five-month old female Sprague Dawley rats were divided into three groups for each time point: age-matched control, HLS, and HLS+DHS. DHS was delivered to the right mid-tibiae with a daily "10 min on-5 min off-10 min on" loading regime for five days/week. At each sacrifice time point, bone marrow MSCs of the stimulated and control tibiae were isolated through specific cell surface markers and quantified by flow cytometry analysis. A strong time-dependent manner of bone marrow MSC induction was observed in response to DHS, which peaked on day 14. After 21 days, this effect of DHS was diminished. This study indicates that the MSC pool is positively influenced by the mechanical signals driven by DHS. Coinciding with our previous findings of mitigation of disuse bone loss, DHS induced changes in MSC number may bias the differentiation of the MSC population towards osteoblastogenesis, thereby promoting bone formation under disuse conditions. This study provides insights into the mechanism of time-sensitive MSC induction in response to mechanical loading, and for the optimal design of osteoporosis treatments.

  19. 48 CFR 3052.219-72 - Evaluation of prime contractor participation in the DHS mentor-protégé program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... contractor participation in the DHS mentor-protégé program. 3052.219-72 Section 3052.219-72 Federal... Evaluation of prime contractor participation in the DHS mentor-protégé program. As prescribed in (HSAR) 48... the DHS Mentor-Protégé Program (JUN 2006) This solicitation contains a source selection factor or...

  20. Minocycline-Induced Drug Hypersensitivity Syndrome Followed by Multiple Autoimmune Sequelae

    PubMed Central

    Brown, Rebecca J.; Rother, Kristina I.; Artman, Henry; Mercurio, Mary Gail; Wang, Roger; Looney, R. John; Cowen, Edward W.

    2010-01-01

    Background Drug hypersensitivity syndrome (DHS) is a severe, multisystem adverse drug reaction that may occur following the use of numerous medications, including anticonvulsants, sulfonamides, and minocycline hydrochloride. Long-term autoimmune sequelae of DHS have been reported, including hypothyroidism. Observations A 15-year-old female adolescent developed DHS 4 weeks after starting minocycline therapy for acne vulgaris. Seven weeks later she developed autoimmune hyperthyroidism (Graves disease), and 7 months after discontinuing minocycline therapy she developed autoimmune type 1 diabetes mellitus. In addition, she developed elevated titers of several markers of systemic autoimmune disease, including antinuclear, anti-Sjögren syndrome A, and anti-Smith antibodies. Conclusions Minocycline-associated DHS may be associated with multiple autoimmune sequelae, including thyroid disease, type 1 diabetes mellitus, and elevated markers of systemic autoimmunity. Long-term follow-up is needed in patients with DHS to determine the natural history of DHS-associated sequelae. PMID:19153345

  1. 5 CFR 9701.410 - DHS responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its performance management system(s), DHS must— (a) Transfer ratings between subordinate organizations and to... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM...

  2. 5 CFR 9701.410 - DHS responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its performance management system(s), DHS must— (a) Transfer ratings between subordinate organizations and to... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM...

  3. 5 CFR 9701.410 - DHS responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its performance management system(s), DHS must— (a) Transfer ratings between subordinate organizations and to... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM...

  4. A survey of dental hygienists in the United Kingdom in 2011. Part 1--demographics and working patterns as dental hygienists.

    PubMed

    Eaton, K A; Harris, M; Ross, M K; Arevalo, C

    2012-11-01

    The aims of this survey were to establish the demographic profile of dental hygienists (DHs) and dental hygienist/therapists (DH/Ts) in the United Kingdom in 2011 and their patterns of practice as DHs. A 10% sample of all those registered with the General Dental Council as DHs or DH/Ts in April 2011 were sent a pre-piloted questionnaire, explanatory letter and stamped addressed envelope. The questionnaire contained a total of 100 questions, 24 of which related to demographics and working patterns. All 100 questions were solely on tasks/work performed by DH, none related to other types of work performed by DH/Ts. Three mailings were distributed between May and July 2011. The resulting data were entered into an Excel spreadsheet. Where appropriate, differences between the responses from DHs and DH/Ts were statistically tested with the chi-squared test. Five hundred and sixty-one DHs and DH/Ts were sent the questionnaire, by the third mailing 371 (66.1%) had responded and returned completed questionnaires. The respondents were 288 DHs, 79 DH/Ts and 4 who did not specify which category they were. The mean year of qualification of the DHs was 1990 and for the DH/Ts 2005. One hundred and twenty-four (33%) reported that they worked full-time, 235 (63%) part-time and the remainder that they were not working as DHs or DH/Ts or had retired. The average number of clinical hours worked per week was reported as 24.6 hours for DHs and 25 hours for DH/Ts, but there were regional variations. For DHs the mean percentage of patients treated under NHS contract was 15.5% and for DH/Ts it was 40.2%. Again there were regional variations and in Scotland these figures were 45.5% for DHs and 70% for DH/Ts. Two hundred and forty-eight (69%) of all respondents were either fully or partly self-employed and 221 (62.7%) worked in two or more locations. The results of this study provide a snapshot of the demographics and practice patterns of DHs and DH/Ts in the UK in the summer of 2011. They confirm the results of a survey that was conducted in England in early 2011 and of a survey that took place in Scotland in 2009.

  5. PCE solubilization and mobilization by commercial humic acid

    NASA Astrophysics Data System (ADS)

    Johnson, William P.; John, W. Wynn

    1999-01-01

    In this paper, comparison is made of terms describing solubilization of hydrophobic organic compounds (HOC) by dissolved humic substances (DHS) and commercial non-ionic surfactants. This paper examines the ability of a commercial humic acid (Aldrich humic acid) to solubilize and mobilize tetrachlorothene (PCE) residual in porous media. The constant for solubilization of PCE by Aldrich humic acid is shown to be a factor of two to thirty times less than that published for dodecyl alcohol ethoxylate surfactants, showing that Aldrich humic acid is less capable than some non-ionic surfactants at solubilizing residual PCE. The depression of PCE-water interfacial tension in the presence of DHS is shown to be significantly less than published values for a non-ionic surfactant, and surfactant mixtures, indicating that the DHS used in this study is less prone to cause mobilization of non-aqueous phase liquids relative to surfactants. Several possible advantages of DHS use in the remediation of subsurface media contaminated with HOC are described, including the ability of DHS to solubilize HOC irrespective of the DHS concentration, and potential lesser tendency of DHS to depress the interfacial tension between non-aqueous phases and water relative to surfactants (an advantage when mobilization is undesired).

  6. Dropped head syndrome after cervical laminoplasty: A case control study.

    PubMed

    Koda, Masao; Furuya, Takeo; Kinoshita, Tomoaki; Miyashita, Tomohiro; Ota, Mitsutoshi; Maki, Satoshi; Ijima, Yasushi; Saito, Junya; Takahashi, Kazuhisa; Yamazaki, Masashi; Aramomi, Masaaki; Mannoji, Chikato

    2016-10-01

    Dropped head syndrome (DHS) is characterized by apparent neck extensor muscle weakness and difficulty extending the neck to raise the head against gravity. The aim of the present study was to elucidate possible risk factors for DHS after cervical laminoplasty. Five patients who developed DHS after cervical laminoplasty (DHS group) and twenty age-matched patients who underwent laminoplasty without DHS after surgery (control group) were compared. The surgical procedure was single-door laminoplasty with strut grafting using resected spinous processes or hydroxyapatite spacers from C3 to C6 or C7. Analyses of preoperative images including the C2-C7 angle, C7-T1 kyphosis, T1 tilt, center of gravity line from the head-C7 sagittal vertical axis (CGH-C7 SVA) were performed on lateral plain cervical spine radiographs. Preoperative T2-weighted MRI at the C5 vertebral level was used to measure the cross-sectional area of the deep extensor muscles. Widths of the lateral gutters were assessed postoperatively using CT scans of the C5 vertebral body. The average preoperative C2-C7 angle was significantly smaller in the DHS group compared with the control group. The average preoperative C7-T1 angle was significantly larger in the DHS group compared with the control group. The average preoperative CGH-C7 SVA was significantly larger in the DHS group compared with the control group. In conclusion, patients with more pronounced preoperative C2-C7 kyphosis, C7-T1 kyphosis, and CGH-C7 SVA are more likely to develop DHS following laminoplasty. Copyright © 2016. Published by Elsevier Ltd.

  7. 49 CFR 1507.3 - Exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... exempt from the access provisions of subsection (d). (c) Personnel Background Investigation File System (DHS/TSA 004). The Personnel Background Investigation File System (PBIFS) (DHS/TSA 004) enables TSA to... Traveler Operations Files (DHS/TSA 015). The purpose of this system is to pre-screen and positively...

  8. 49 CFR 1507.3 - Exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... exempt from the access provisions of subsection (d). (c) Personnel Background Investigation File System (DHS/TSA 004). The Personnel Background Investigation File System (PBIFS) (DHS/TSA 004) enables TSA to... Traveler Operations Files (DHS/TSA 015). The purpose of this system is to pre-screen and positively...

  9. 49 CFR 1507.3 - Exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... exempt from the access provisions of subsection (d). (c) Personnel Background Investigation File System (DHS/TSA 004). The Personnel Background Investigation File System (PBIFS) (DHS/TSA 004) enables TSA to... Traveler Operations Files (DHS/TSA 015). The purpose of this system is to pre-screen and positively...

  10. 49 CFR 1507.3 - Exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... exempt from the access provisions of subsection (d). (c) Personnel Background Investigation File System (DHS/TSA 004). The Personnel Background Investigation File System (PBIFS) (DHS/TSA 004) enables TSA to... Traveler Operations Files (DHS/TSA 015). The purpose of this system is to pre-screen and positively...

  11. 78 FR 57643 - Agency Information Collection Activities: Department of Homeland Security (DHS) Cybersecurity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... Security (DHS) Cybersecurity Education Office (CEO) National Initiative for Cybersecurity Careers and Studies (NICCS) Cybersecurity Training and Education Catalog (Training Catalog) Collection AGENCY: Cybersecurity Education Office, DHS. ACTION: 30-Day Notice and request for comments; New Collection (Request for...

  12. 78 FR 35295 - Agency Information Collection Activities: Department of Homeland Security (DHS) Cybersecurity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... Security (DHS) Cybersecurity Education Office (CEO) National Initiative for Cybersecurity Careers and Studies (NICCS) Cybersecurity Training and Education Catalog (Training Catalog) Collection AGENCY: Cybersecurity Education Office, DHS. ACTION: 60-Day Notice and request for comments; New Collection (Request for...

  13. 76 FR 10384 - Agency Information Collection Activities: Regulation on Agency Protests

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Protests AGENCY: Office of Chief Procurement Officer, Acquisition Policy and Legislation Office, DHS... Department of Homeland Security, Office of Chief Procurement Officer, Acquisition Policy and Legislation... comments were received by DHS. DHS would also like to correct the Total Burden Cost (capital/startup): $4...

  14. 77 FR 13135 - Agency Information Collection Activities: Submission for Review; Information Collection Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... (DHS), Science and Technology, Protected Repository for the Defense of Infrastructure Against Cyber Threats (PREDICT) Program AGENCY: Science and Technology Directorate, DHS. ACTION: 30-Day notice and request for comment. SUMMARY: The Department of Homeland Security (DHS), Science & Technology (S&T...

  15. 5 CFR 9701.231 - Conversion of positions and employees to the DHS classification system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the DHS classification system. 9701.231 Section 9701.231 Administrative Personnel DEPARTMENT OF... MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Classification Transitional Provisions § 9701.231 Conversion of positions and employees to the DHS classification system. (a) This...

  16. 75 FR 12445 - Name Change of Two DHS Components

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection U.S. Immigration and Customs... Components AGENCY: U.S. Customs and Border Protection, DHS; U.S. Immigration and Customs Enforcement, DHS; Department of the Treasury. ACTION: Final rule. SUMMARY: On March 31, 2007, the name of the Bureau of Customs...

  17. ERCMExpress. Volume 2, Issue 4

    ERIC Educational Resources Information Center

    US Department of Education, 2006

    2006-01-01

    This issue of ERCMExpress alerts readers of the All-Hazard NOAA weather radio (NWR) network upgrade. In 2004, The National Oceanic and Atmospheric Administration NOAA and the U.S. Department of Homeland Security (DHS) collaborated to enable DHS to disseminate homeland security-related information over the NWR network. DHS's goal was to produce an…

  18. 75 FR 55529 - Homeland Security Acquisition Regulation (HSAR); Revision Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-13

    ... (b) of HSAR section 3003.1004 advises contracting officers that special posters and instructions may... DHS Hotline Poster described in the clause at FAR 52.203-14. Part 3004 Administrative Matters Revise...)(1) There may be different or additional DHS OIG hotline posters for specific events. When the DHS...

  19. 76 FR 60510 - DHS Data Privacy and Integrity Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... Arlington, Virginia. This notice supplements that original meeting notice. DATES: The DHS Data Privacy and... original notice. Please include the Docket Number (DHS 2011-0076) in your comments. A public comment period... original notice or sign up at the registration desk on the day of the meeting. FOR FURTHER INFORMATION...

  20. 76 FR 58814 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... the Web AGENCY: Privacy Office, DHS. ACTION: Notice of Publication of Privacy Impact Assessments (PIA... DHS. These assessments were approved and published on the Privacy Office's Web site between June 1, 2011 and August 31, 2011. DATES: The PIAs will be available on the DHS Web site until November 21, 2011...

  1. 77 FR 33683 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security, U.S. Customs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... Border Protection, DHS/CBP--017 Analytical Framework for Intelligence (AFI) System of Records AGENCY... Framework for Intelligence (AFI) System of Records'' and this proposed rulemaking. In this proposed... Protection, DHS/CBP--017 Analytical Framework for Intelligence (AFI) System of Records.'' AFI enhances DHS's...

  2. 78 FR 44957 - Agency Information Collection Activities: BioWatch Filter Holder Log, Filter Holder Log DHS Form...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... DEPARTMENT OF HOMELAND SECURITY Agency Information Collection Activities: BioWatch Filter Holder Log, Filter Holder Log DHS Form 9500 AGENCY: Office of Health Affairs, DHS. ACTION: 60-Day Notice and....: Daniel Yereb, [email protected] 703- 647-8052. SUPPLEMENTARY INFORMATION: Following collection, the filter...

  3. 2 CFR 3001.300 - Who in DHS does a recipient who is an individual notify about a criminal drug conviction?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Who in DHS does a recipient who is an... WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are Individuals § 3001.300 Who in DHS does... recipient currently has an award. ...

  4. 2 CFR 3001.300 - Who in DHS does a recipient who is an individual notify about a criminal drug conviction?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Who in DHS does a recipient who is an... WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are Individuals § 3001.300 Who in DHS does... recipient currently has an award. ...

  5. 2 CFR 3001.300 - Who in DHS does a recipient who is an individual notify about a criminal drug conviction?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Who in DHS does a recipient who is an... WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are Individuals § 3001.300 Who in DHS does... recipient currently has an award. ...

  6. 77 FR 74490 - Implementation of Immigrant Visa DHS Domestic Processing Fee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Docket No. USCIS-2009-0033] RIN 1615-ZB13 Implementation of Immigrant Visa DHS Domestic Processing Fee... will begin to collect a $165 Immigrant Visa DHS Domestic Processing Fee (USCIS Immigrant Fee) from individuals who have been issued immigrant visas by the U.S. Department of State (DOS) and are applying for...

  7. Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells.

    PubMed

    Da Silva, Daniel; Lachaud, Christophe; Cotelle, Valérie; Brière, Christian; Grat, Sabine; Mazars, Christian; Thuleau, Patrice

    2011-05-01

    Sphinganine or dihydrosphingosine (d18:0, DHS), one of the most abundant free sphingoid Long Chain Base (LCB) in plants, is known to induce a calcium dependent programmed cell death (PCD) in tobacco BY-2 cells. In addition, we have recently shown that DHS triggers a production of H2O2, via the activation of NADPH oxidase(s). However, this production of H2O2 is not correlated with the DHS-induced cell death but would rather be associated with basal cell defense mechanisms. In the present study, we extend our current knowledge of the DHS signaling pathway, by demonstrating that DHS also promotes a production of nitric oxide (NO) in tobacco BY-2 cells. As for H2O2, this NO production is not necessary for cell death induction. 

  8. Treatment of hazardous landfill leachate using Fenton process followed by a combined (UASB/DHS) system.

    PubMed

    Ismail, Sherif; Tawfik, Ahmed

    2016-01-01

    Fenton process for pre-treatment of hazardous landfill leachate (HLL) was investigated. Total, particulate and soluble chemical oxygen demand (CODt, CODp and CODs) removal efficiency amounted to 67%, 47% and 64%, respectively, at pH value of 3.5, molar ratio (H2O2/Fe(2+)) of 5, H2O2 dosage of 25 ml/L and contact time of 15 min. Various treatment scenarios were attempted and focused on studying the effect of pre-catalytic oxidation process on the performance of up-flow anaerobic sludge blanket (UASB), UASB/down-flow hanging sponge (DHS) and DHS system. The results obtained indicated that pre-catalytic oxidation process improved the CODt removal efficiency in the UASB reactor by a value of 51.4%. Overall removal efficiencies of CODt, CODs and CODp were 80 ± 6%, 80 ± 7% and 78 ± 16% for UASB/DHS treating pre-catalytic oxidation effluent, respectively. The removal efficiencies of CODt, CODs and CODp were, respectively, decreased to 54 ± 2%, 49 ± 2% and 71 ± 16% for UASB/DHS system without pre-treatment. However, the results for the combined process (UASB/DHS) system is almost similar to those obtained for UASB reactor treating pre-catalytic oxidation effluent. The DHS system achieved average removal efficiencies of 52 ± 4% for CODt, 51 ± 4% for CODs and 52 ± 15% for CODp. A higher COD fractions removal was obtained when HLL was pre-treated by Fenton reagent. The combined processes provided a removal efficiency of 85 ± 1% for CODt, 85 ± 1% for CODs and 83 ± 8% for CODp. The DHS system is not only effective for organics degradation but also for ammonia oxidation. Almost complete ammonia (NH4-N) removal (92 ± 3.6%) was occurred and the nitrate production amounted to 37 ± 6 mg/L in the treated effluent. This study strongly recommends applying Fenton process followed by DHS system for treatment of HLL.

  9. Removal of human pathogenic viruses in a down-flow hanging sponge (DHS) reactor treating municipal wastewater and health risks associated with utilization of the effluent for agricultural irrigation.

    PubMed

    Kobayashi, Naohiro; Oshiki, Mamoru; Ito, Toshihiro; Segawa, Takahiro; Hatamoto, Masashi; Kato, Tsuyoshi; Yamaguchi, Takashi; Kubota, Kengo; Takahashi, Masanobu; Iguchi, Akinori; Tagawa, Tadashi; Okubo, Tsutomu; Uemura, Shigeki; Harada, Hideki; Motoyama, Toshiki; Araki, Nobuo; Sano, Daisuke

    2017-03-01

    A down-flow hanging sponge (DHS) reactor has been developed as a cost-effective wastewater treatment system that is adaptable to local conditions in low-income countries. A pilot-scale DHS reactor previously demonstrated stable reduction efficiencies for chemical oxygen demand (COD) and ammonium nitrogen over a year at ambient temperature, but the pathogen reduction efficiency of the DHS reactor has yet to be investigated. In the present study, the reduction efficiency of a pilot-scale DHS reactor fed with municipal wastewater was investigated for 10 types of human pathogenic viruses (norovirus GI, GII and GIV, aichivirus, astrovirus, enterovirus, hepatitis A and E viruses, rotavirus, and sapovirus). DHS influent and effluent were collected weekly or biweekly for 337 days, and concentrations of viral genomes were determined by microfluidic quantitative PCR. Aichivirus, norovirus GI and GII, enterovirus, and sapovirus were frequently detected in DHS influent, and the log 10 reduction (LR) of these viruses ranged from 1.5 to 3.7. The LR values for aichivirus and norovirus GII were also calculated using a Bayesian estimation model, and the average LR (±standard deviation) values for aichivirus and norovirus GII were estimated to be 1.4 (±1.5) and 1.8 (±2.5), respectively. Quantitative microbial risk assessment was conducted to calculate a threshold reduction level for norovirus GII that would be required for the use of DHS effluent for agricultural irrigation, and it was found that LRs of 2.6 and 3.7 for norovirus GII in the DHS effluent were required in order to not exceed the tolerable burden of disease at 10 -4 and 10 -6 disability-adjusted life years loss per person per year, respectively, for 95% of the exposed population during wastewater reuse for irrigation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. 20 CFR 655.670 - Federal Register notice of determination of prevailing practice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... subparts F and G of this part; the DHS and ETA shall, upon notice from the Administrator, take the actions... § 655.655). The DHS and ETA shall upon notice from the Administrator, take the actions specified in... DHS and ETA. (1) Where the Secretary reverses the administrative law judge and determines that...

  11. 77 FR 46100 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ... the Web AGENCY: Privacy Office, DHS. ACTION: Notice of publication of Privacy Impact Assessments (PIA... published on the Privacy Office's Web site between March 1, 2012 and May 31, 2012. DATES: The PIAs will be available on the DHS Web site until October 1, 2012, after which they may be obtained by contacting the DHS...

  12. 76 FR 8761 - Privacy Act of 1974; U.S. Immigration and Customs Enforcement, DHS/ICE-004 Bond Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... 1974; U.S. Immigration and Customs Enforcement, DHS/ICE-004 Bond Management Information System (BMIS... Bond Management Information System (74 FR 57891, Dec. 21, 2009) expand the categories of records... a U.S. Immigration and Customs Enforcement system of records titled DHS/ICE-004 Bond Management...

  13. 75 FR 55335 - Privacy Act of 1974; Privacy Act of 1974: Department of Homeland Security/ALL-031 Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... in a system of records in the possession or under the control of DHS by complying with DHS Privacy... 1974; Privacy Act of 1974: Department of Homeland Security/ALL-031 Information Sharing Environment Suspicious Activity Reporting Initiative System of Records AGENCY: Privacy Office, DHS. ACTION: Notice of...

  14. 2 CFR 3001.225 - Who in DHS does a recipient other than an individual notify about a criminal drug conviction?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Who in DHS does a recipient other than an... does a recipient other than an individual notify about a criminal drug conviction? A recipient other... DHS office from which the recipient currently has an award. ...

  15. 2 CFR 3001.225 - Who in DHS does a recipient other than an individual notify about a criminal drug conviction?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Who in DHS does a recipient other than an... does a recipient other than an individual notify about a criminal drug conviction? A recipient other... DHS office from which the recipient currently has an award. ...

  16. 2 CFR 3001.225 - Who in DHS does a recipient other than an individual notify about a criminal drug conviction?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Who in DHS does a recipient other than an... does a recipient other than an individual notify about a criminal drug conviction? A recipient other... DHS office from which the recipient currently has an award. ...

  17. 8 CFR 1208.5 - Special duties toward aliens in custody of DHS.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the custody of DHS requests asylum or withholding of removal, or expresses a fear of persecution or...)(4) of the Act, except in the case of an alien who is in custody pending a credible fear determination under 8 CFR 1208.30 or a reasonable fear determination pursuant to 8 CFR 1208.31. Although DHS...

  18. Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells*

    PubMed Central

    Mao, Zhehao; Sun, Wei; Xu, Ruijuan; Novgorodov, Sergei; Szulc, Zdzislaw M.; Bielawski, Jacek; Obeid, Lina M.; Mao, Cungui

    2010-01-01

    Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has been implicated in the cytotoxicity of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in tumor cells. However, how 4-HPR increases DHS remains unclear. Here we demonstrate that 4-HPR increases the expression of ACER2, which catalyzes the hydrolysis of dihydroceramides to generate DHS, and that ACER2 up-regulation plays a key role in mediating the 4-HPR-induced generation of DHS as well as the cytotoxicity of 4-HPR in tumor cells. Treatment with 4-HPR induced the accumulation of dihydroceramides (DHCs) in tumor cells by inhibiting dihydroceramide desaturase (DES) activity, which catalyzes the conversion of DHCs to ceramides. Treatment with 4-HPR also increased ACER2 expression through a retinoic acid receptor-independent and caspase-dependent manner. Overexpression of ACER2 augmented the 4-HPR-induced generation of DHS as well as 4-HPR cytotoxicity, and 4-HPR-induced death in tumor cells, whereas knocking down ACER2 had the opposite effects. ACER2 overexpression, along with treatment with GT11, another DES inhibitor, markedly increased cellular DHS, leading to tumor cell death, whereas ACER2 overexpression or GT11 treatment alone failed to do so, suggesting that both ACER2 up-regulation and DES inhibition are necessary and sufficient to mediate 4-HPR-induced DHS accumulation, cytotoxicity, and death in tumor cells. Taken together, these results suggest that up-regulation of the ACER2/DHS pathway mediates the cytotoxicity of 4-HPR in tumor cells and that up-regulating or activating ACER2 may improve the anti-cancer activity of 4-HRR and other DHC-inducing agents. PMID:20628055

  19. 76 FR 66933 - Privacy Act of 1974; Department of Homeland Security U.S. Coast Guard DHS/USCG-014 Military Pay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... purpose of health and life insurance requests and eligibility and to the Department of Defense (DoD) for... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0072] Privacy Act of 1974; Department of Homeland Security U.S. Coast Guard DHS/USCG--014 Military Pay and Personnel System...

  20. 6 CFR Appendix A to Part 27 - DHS Chemicals of Interest

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false DHS Chemicals of Interest A Appendix A to Part 27 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Pt. 27, App. A Appendix A to Part 27—DHS Chemicals of Interest ER20NO07.008 ER20NO07.009...

  1. 6 CFR Appendix A to Part 27 - DHS Chemicals of Interest

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false DHS Chemicals of Interest A Appendix A to Part 27 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Pt. 27, App. A Appendix A to Part 27—DHS Chemicals of Interest ER20NO07.008 ER20NO07.009...

  2. 76 FR 49494 - Privacy Act of 1974; Department of Homeland Security United States Coast Guard DHS/USCG-027...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0062] Privacy Act of 1974; Department of Homeland Security United States Coast Guard DHS/USCG-027 Recruiting Files System of... accordance with the Privacy Act of 1974 the Department of Homeland Security proposes to update and reissue an...

  3. 6 CFR Appendix A to Part 27 - DHS Chemicals of Interest

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false DHS Chemicals of Interest A Appendix A to Part 27 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Pt. 27, App. A Appendix A to Part 27—DHS Chemicals of Interest ER20NO07.008 ER20NO07.009...

  4. 6 CFR Appendix A to Part 27 - DHS Chemicals of Interest

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false DHS Chemicals of Interest A Appendix A to Part 27 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Pt. 27, App. A Appendix A to Part 27—DHS Chemicals of Interest ER20NO07.008 ER20NO07.009...

  5. 6 CFR Appendix A to Part 27 - DHS Chemicals of Interest

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false DHS Chemicals of Interest A Appendix A to Part 27 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Pt. 27, App. A Appendix A to Part 27—DHS Chemicals of Interest ER20NO07.008 ER20NO07.009...

  6. 76 FR 81787 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security/ALL-030 Use of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... requirements for the agency (DHS) to respect individuals' rights to control their information in possession of... Database System of Records is a repository of information held by DHS in connection with its several and.... The DHS/ALL-030 Use of Terrorist Screening Database System of Records contains information that is...

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moroz, P.E.

    A new stellarator configuration, the Double-Helix Stellarator (DHS), is introduced. This novel configuration features a double-helix center post as the only helical element of the stellarator coil system. The DHS configuration has many unique characteristics. One of them is the extreme low plasma aspect ratio, A {approx} 1--1.2. Other advantages include a high enclosed volume, appreciable rotational transform, and a possibility of extreme-high-{beta} MHD equilibria. Moreover, the DHS features improved transport characteristics caused by the absence of the magnetic field ripple on the outboard of the torus. Compactness, simplicity and modularity of the coil system add to the DHS advantagesmore » for fusion applications.« less

  8. FY16 Analysis report: Financial systems dependency on communications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Beyeler, Walter E.

    Within the Department of Homeland Security (DHS), the Office of Cyber and Infrastructure Analysis (OCIA)'s National Infrastructure Simulation and Analysis Center (NISAC) develops capabilities to support the DHS mission and the resilience of the Nation’s critical infrastructure. At Sandia National Laboratories, under DHS/OCIA direction, NISAC is developing models of financial sector dependence on communications. This capability is designed to improve DHS's ability to assess potential impacts of communication disruptions to major financial services and the effectiveness of possible mitigations. This report summarizes findings and recommendations from the application of that capability as part of the FY2016 NISAC program plan.

  9. Characteristics of large thermal energy storage systems in Poland

    NASA Astrophysics Data System (ADS)

    Zwierzchowski, Ryszard

    2017-11-01

    In District Heating Systems (DHS) there are significant fluctuations in demand for heat by consumers during both the heating and the summer seasons. These variations are considered primarily in the 24-hour time horizon. These problems are aggravated further if the DHS is supplied by a CHP plant, because fluctuations in heat demand adversely affect to a significant degree the stable production of electricity at high overall efficiency. Therefore, introducing Thermal Energy Storage (TES) would be highly recommended on these grounds alone. The characteristics of Large (i.e. over 10 000 m3) TES in operation in Poland are presented. Information is given regarding new projects (currently in design or construction) that apply TES technology in DHS in Poland. The paper looks at the methodology used in Poland to select the TES system for a particular DHS, i.e., procedure for calculating capacity of the TES tank and the system to prevent water stored in the tank from absorbing oxygen from atmospheric air. Implementation of TES in DHS is treated as a recommended technology in the Polish District Heating sector. This technology offers great opportunities to improve the operating conditions of DHS, cutting energy production costs and emissions of pollutants to the atmosphere.

  10. Evaluation of the resilience of a full-scale down-flow hanging sponge reactor to long-term outages at a sewage treatment plant in India.

    PubMed

    Onodera, Takashi; Takayama, Daisuke; Ohashi, Akiyoshi; Yamaguchi, Takashi; Uemura, Shigeki; Harada, Hideki

    2016-10-01

    Resilience to process outages is an essential requirement for sustainable wastewater treatment systems in developing countries. In this study, we evaluated the ability of a full-scale down-flow hanging sponge (DHS) reactor to recover after a 10-day outage. The DHS tested in this study uses polyurethane sponge as packing material. This full-scale DHS reactor has been tested over a period of about 4 years in India with a flow rate of 500 m(3)/day. Water was not supplied to the DHS reactor that was subjected to the 10-day outage; however, the biomass did not dry out because the sponge was able to retain enough water. Soon after the reactor was restarted, a small quantity of biomass, amounting to only 0.1% of the total retained biomass, was eluted. The DHS effluent achieved satisfactory removal of suspended solids, chemical oxygen demand, and ammonium nitrogen within 90, 45, and 90 min, respectively. Conversely, fecal coliforms in the DHS effluent did not reach satisfactory levels within 540 min; instead, the normal levels of fecal coliforms were achieved within 3 days. Overall, the tests demonstrated that the DHS reactor was sufficiently robust to withstand long-term outages and achieved steady state soon after restart. This reinforces the suitability of this technology for developing countries. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. The Department of Homeland Security Intelligence Enterprise: Operational Overview and Oversight Challenges for Congress

    DTIC Science & Technology

    2009-05-27

    technology network architecture to connect various DHS elements and promote information sharing.17 • Establish a DHS State, Local, and Regional...A Strategic Plan; training, and the implementation of a comprehensive information systems architecture .65 As part of its integration...information technology network architecture was submitted to Congress last year. See DHS I&A, Homeland Security Information Technology Network

  12. Army Support during the Hurricane Katrina Disaster

    DTIC Science & Technology

    2009-01-01

    Human Capital Reform Act of 2004. 3. John D. Banusiewicz, “Bush Calls for Broader Military Disaster Response Role,” American Forces Press Service...Management (DHS/FEMA) ESF #6, Mass Care, Housing, and Human Services (DHS/FEMA) ESF #7, Resource Support (Government Services Administration) ESF #8...Public Health and Medical Services (Department of Health and Human Services) ESF #9, Urban Search and Rescue (DHS/FEMA) ESF #10, Oil and Hazardous

  13. The Department of Homeland Security Intelligence Enterprise: Operational Overview and Oversight Challenges for Congress

    DTIC Science & Technology

    2010-03-19

    network architecture to connect various DHS elements and promote information sharing.17 • Establish a DHS State, Local, and Regional Fusion Center...of reports; the I&A Strategic Plan; training, and the implementation of a comprehensive information systems architecture .73 As part of its...comprehensive information technology network architecture was submitted to Congress last year. See DHS I&A, Homeland Security Information Technology Network

  14. Energy saving system with high effluent quality for municipal sewage treatment by UASB-DHS.

    PubMed

    Tanaka, H; Takahashi, M; Yoneyama, Y; Syutsubo, K; Kato, K; Nagano, A; Yamaguchi, T; Harada, H

    2012-01-01

    An up-flow anaerobic sludge blanket (UASB) - down-flow hanging sponge (DHS) was applied to Japanese municipal sewage treatment, and its treatability, energy consumption, and sludge production were evaluated. The designed sewage load was 50 m(3)/d. The sewage typically had a chemical oxygen demand (COD) of 402 mg/L, a suspended solids (SS) content of 167 mg/L, and a temperature of 17-29 °C. The UASB and DHS exhibited theoretical hydraulic retention times of 9.7 and 2.5 h, respectively. The entire system was operated without temperature control. Operation was started with mesophilic anaerobic digested sludge for the UASB and various sponge media for the DHS. Continuous operational data suggest that although the cellulose decomposition and methanogenic process in the UASB are temperature sensitive, stable operation can be obtained by maintaining a satisfactory sludge volume index and sludge concentration. For the DHS, the cube-type medium G3-2 offers superior filling rates, biological preservation and operational execution. The SS derived from the DHS contaminated the effluent but could be removed by optional sand filtration. A comparison with conventional activated sludge (CAS) treatment confirmed that this system is adequate for municipal sewage treatment, with an estimated energy requirement and excess sludge production approximately 75 and 85% less than those of CAS, respectively.

  15. Chemical and spectroscopic characterization of dissolved humic substances in a mangrove-fringed estuary in the eastern coast of Hainan Island, China

    NASA Astrophysics Data System (ADS)

    Zhang, Yaoling; Du, Jinzhou; Peng, Bo; Zhang, Fenfen; Zhao, Xin; Zhang, Jing

    2013-03-01

    Mangrove-derived dissolved organic matter (DOM) has an important effect on estuarine and coastal area on a large scale. In order to improve the understanding of origin, composition, and fate of DOM in mangrove-fringed estuarine and coastal areas, dissolved humic substances (DHS) were isolated from one mangrove pore-water sample and one near-shore seawater sample downstream the mangrove pore-water site in the eastern coast of Hainan Island, South China. Fulvic acids, humic acids and XAD-4 fractions were obtained from the two water samples by using a two-column array of XAD-8 and XAD-4 resins. Chemical and spectroscopic methods were used to analyze the features of these DHS. Compared to the mangrove pore-water DHS, the near-shore seawater DHS were found rich in 13C with lower C/N ratios and more aliphatic compounds and carbohydrates, but less aromatic structures and carboxyl groups. As for the three fractions of the two DHS, XAD-4 fractions contain more aliphatics, carbohydrates, carboxyl groups, and enrich in 13C with respect to both fulvic and humic acids. Photo-oxidation transformation and contribution from marine-derived DOM were considered as the main reasons resulted in the difference in compositional features for these DHS in this study.

  16. Evaluation of the process performance of a down-flow hanging sponge reactor for direct treatment of domestic wastewater in Bangkok, Thailand.

    PubMed

    Miyaoka, Yuma; Yoochatchaval, Wilasinee; Sumino, Haruhiko; Banjongproo, Pathan; Yamaguchi, Takashi; Onodera, Takashi; Okadera, Tomohiro; Syutsubo, Kazuaki

    2017-08-24

    This study assesses the performance of an aerobic trickling filter, down-flow hanging sponge (DHS) reactor, as a decentralized domestic wastewater treatment technology. Also, the characteristic eukaryotic community structure in DHS reactor was investigated. Long-term operation of a DHS reactor for direct treatment of domestic wastewater (COD = 150-170 mg/L and BOD = 60-90 mg/L) was performed under the average ambient temperature ranged from 28°C to 31°C in Bangkok, Thailand. Throughout the evaluation period of 550 days, the DHS reactor at a hydraulic retention time of 3 h showed better performance than the existing oxidation ditch process in the removal of organic carbon (COD removal rate = 80-83% and BOD removal rate = 91%), nitrogen compounds (total nitrogen removal rate = 45-51% and NH 4 + -N removal rate = 95-98%), and low excess sludge production (0.04 gTS/gCOD removed). The clone library based on the 18S ribosomal ribonucleic acid gene sequence revealed that phylogenetic diversity of 18S rRNA gene in the DHS reactor was higher than that of the present oxidation ditch process. Furthermore, the DHS reactor also demonstrated sufficient COD and NH 4 + -N removal efficiency under flow rate fluctuation conditions that simulates a small-scale treatment facility. The results show that a DHS reactor could be applied as a decentralized domestic wastewater treatment technology in tropical regions such as Bangkok, Thailand.

  17. [A survivor of Hodgkin lymphoma manifesting dropped head syndrome as a late-onset complication of radiotherapy: a case report].

    PubMed

    Kaido, Misako; Yuasa, Yoshihito; Ikeda, Hiroshi

    2018-05-25

    We report the case of a 50-year-old female survivor of Hodgkin lymphoma (HL), who developed dropped head syndrome (DHS). The patient was diagnosed with HL at 20 years of age, and underwent chemo-radiotherapy, which led to complete remission. Undergoing supplemental therapy for post-radiation hypothyroidism, she had twin babies. She noticed white stains on her neck at the age of 30, and the decolored area gradually expanded. Sixteen years after the radiotherapy (RT), her posterior neck muscle strength began to decline. She had to make considerable efforts to keep her neck straight, and came to experience a severe pain in the neck and shoulders. The patient visited our department due to DHS at the age of 50. She had leukoderma, muscle weakness, and muscle atrophy in the neck and para-spinal region, which were consistent with the area of RT. The strength was preserved in the other parts of the muscle, including the proximal upper limbs. Sensory nerve disorder was not detected. The serum creatine kinase level was slightly elevated. Cervical spine or cervical cord disease that can cause DHS was not detected by MRI examination. The MRI and CT images revealed marked atrophy in the posterior neck and para-spinal muscles. The electromyogram revealed myopathic changes, and the cause of her DHS was diagnosed as radiation-induced myopathy. DHS is a well-known late-onset radiation injury, and Japanese cases have been reported in elderly persons with laryngeal or lung cancer. However, there have been no Japanese case reports of radiation-induced DHS due to RT against HL in younger persons. The patient had visited several clinics and hospitals before she came to our hospital, but RT-induced DHS had been overlooked. Greater recognition and consideration is required for DHS as one of the various issues arising after long passage of HL survivors.

  18. Extension of a dynamic headspace multi-volatile method to milliliter injection volumes with full sample evaporation: Application to green tea.

    PubMed

    Ochiai, Nobuo; Sasamoto, Kikuo; Tsunokawa, Jun; Hoffmann, Andreas; Okanoya, Kazunori; MacNamara, Kevin

    2015-11-20

    An extension of multi-volatile method (MVM) technology using the combination of a standard dynamic headspace (DHS) configuration, and a modified DHS configuration incorporating an additional vacuum module, was developed for milliliter injection volume of aqueous sample with full sample evaporation. A prior step involved investigation of water management by weighing of the water residue in the adsorbent trap. The extended MVM for 1 mL aqueous sample consists of five different DHS method parameter sets including choice of the replaceable adsorbent trap. An initial two DHS sampling sets at 25°C with the standard DHS configuration using a carbon-based adsorbent trap target very volatile solutes with high vapor pressure (>10 kPa) and volatile solutes with moderate vapor pressure (1-10 kPa). Subsequent three DHS sampling sets at 80°C with the modified DHS configuration using a Tenax TA trap target solutes with low vapor pressure (<1 kPa) and/or hydrophilic characteristics. After the five sequential DHS samplings using the same HS vial, the five traps are sequentially desorbed with thermal desorption in reverse order of the DHS sampling and the desorbed compounds are trapped and concentrated in a programmed temperature vaporizing (PTV) inlet and subsequently analyzed in a single GC-MS run. Recoveries of 21 test aroma compounds in 1 mL water for each separate DHS sampling and the combined MVM procedure were evaluated as a function of vapor pressure in the range of 0.000088-120 kPa. The MVM procedure provided high recoveries (>88%) for 17 test aroma compounds and moderate recoveries (44-71%) for 4 test compounds. The method showed good linearity (r(2)>0.9913) and high sensitivity (limit of detection: 0.1-0.5 ng mL(-1)) even with MS scan mode. The improved sensitivity of the method was demonstrated with analysis of a wide variety of aroma compounds in brewed green tea. Compared to the original 100 μL MVM procedure, this extension to 1 mL MVM allowed detection of nearly twice the number of aroma compounds, including 18 potent aroma compounds from top-note to base-note (e.g. 2,3-butanedione, coumarin, furaneol, guaiacol, cis-3-hexenol, linalool, maltol, methional, 3-methyl butanal, 2,3,5-trimethyl pyrazine, and vanillin). Sensitivity for 23 compounds improved by a factor of 3.4-15 under 1 mL MVM conditions. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. The interface between the national tuberculosis control programme and district hospitals in Cameroon: missed opportunities for strengthening the local health system -a multiple case study.

    PubMed

    Keugoung, Basile; Macq, Jean; Buve, Anne; Meli, Jean; Criel, Bart

    2013-03-22

    Tuberculosis remains a major public health problem in sub-Saharan Africa. District hospitals (DHs) play a central role in district-based health systems, and their relation with vertical programmes is very important. Studies on the impact of vertical programmes on DHs are rare. This study aims to fill this gap. Its purpose is to analyse the interaction between the National Tuberculosis Control Programme (NTCP) and DHs in Cameroon, especially its effects on the human resources, routine health information system (HIS) and technical capacity at the hospital level. We used a multiple case study methodology. From the Adamaoua Region, we selected two DHs, one public and one faith-based. We collected qualitative and quantitative data through document reviews, semi-structured interviews with district and regional staff, and observations in the two DHs. The NTCP trained and supervised staff, designed and provided tuberculosis data collection and reporting tools, and provided anti-tuberculosis drugs, reagents and microscopes to DHs. However, these interventions were limited to the hospital units designated as Tuberculosis Diagnostic and Treatment Centres and to staff dedicated to tuberculosis control activities. The NTCP installed a parallel HIS that bypassed the District Health Services. The DH that performs well in terms of general hospital care and that is well managed was successful in tuberculosis control. Based on the available resources, the two hospitals adapt the organisation of tuberculosis control to their settings. The management teams in charge of the District Health Services are not involved in tuberculosis control. In our study, we identified several opportunities to strengthen the local health system that have been missed by the NTCP and the health system managers. Well-managed DHs perform better in terms of tuberculosis control than DHs that are not well managed. The analysis of the effects of the NTCP on the human resources, HIS and technical capacity of DHs indicates that the NTCP supports, rather than strengthens, the local health system. Moreover, there is potential for this support to be enhanced. Positive synergies between the NTCP and district health systems can be achieved if opportunities to strengthen the district health system are seized. The question remains, however, of why managers do not take advantage of the opportunities to strengthen the health system.

  20. The interface between the national tuberculosis control programme and district hospitals in Cameroon: missed opportunities for strengthening the local health system –a multiple case study

    PubMed Central

    2013-01-01

    Background Tuberculosis remains a major public health problem in sub-Saharan Africa. District hospitals (DHs) play a central role in district-based health systems, and their relation with vertical programmes is very important. Studies on the impact of vertical programmes on DHs are rare. This study aims to fill this gap. Its purpose is to analyse the interaction between the National Tuberculosis Control Programme (NTCP) and DHs in Cameroon, especially its effects on the human resources, routine health information system (HIS) and technical capacity at the hospital level. Methods We used a multiple case study methodology. From the Adamaoua Region, we selected two DHs, one public and one faith-based. We collected qualitative and quantitative data through document reviews, semi-structured interviews with district and regional staff, and observations in the two DHs. Results The NTCP trained and supervised staff, designed and provided tuberculosis data collection and reporting tools, and provided anti-tuberculosis drugs, reagents and microscopes to DHs. However, these interventions were limited to the hospital units designated as Tuberculosis Diagnostic and Treatment Centres and to staff dedicated to tuberculosis control activities. The NTCP installed a parallel HIS that bypassed the District Health Services. The DH that performs well in terms of general hospital care and that is well managed was successful in tuberculosis control. Based on the available resources, the two hospitals adapt the organisation of tuberculosis control to their settings. The management teams in charge of the District Health Services are not involved in tuberculosis control. In our study, we identified several opportunities to strengthen the local health system that have been missed by the NTCP and the health system managers. Conclusion Well-managed DHs perform better in terms of tuberculosis control than DHs that are not well managed. The analysis of the effects of the NTCP on the human resources, HIS and technical capacity of DHs indicates that the NTCP supports, rather than strengthens, the local health system. Moreover, there is potential for this support to be enhanced. Positive synergies between the NTCP and district health systems can be achieved if opportunities to strengthen the district health system are seized. The question remains, however, of why managers do not take advantage of the opportunities to strengthen the health system. PMID:23521866

  1. Development of downflow hanging sponge (DHS) reactor as post treatment of existing combined anaerobic tank treating natural rubber processing wastewater.

    PubMed

    Watari, Takahiro; Cuong Mai, Trung; Tanikawa, Daisuke; Hirakata, Yuga; Hatamoto, Masashi; Syutsubo, Kazuaki; Fukuda, Masao; Nguyen, Ngoc Bich; Yamaguchi, Takashi

    2017-01-01

    Conventional aerated tank technology is widely applied for post treatment of natural rubber processing wastewater in Southeast Asia; however, a long hydraulic retention time (HRT) is required and the effluent standards are exceeded. In this study, a downflow hanging sponge (DHS) reactor was installed as post treatment of anaerobic tank effluent in a natural rubber factory in South Vietnam and the process performance was evaluated. The DHS reactor demonstrated removal efficiencies of 64.2 ± 7.5% and 55.3 ± 19.2% for total chemical oxygen demand (COD) and total nitrogen, respectively, with an organic loading rate of 0.97 ± 0.03 kg-COD m -3 day -1 and a nitrogen loading rate of 0.57 ± 0.21 kg-N m -3 day -1 . 16S rRNA gene sequencing analysis of the sludge retained in the DHS also corresponded to the result of reactor performance, and both nitrifying and denitrifying bacteria were detected in the sponge carrier. In addition, anammox bacteria was found in the retained sludge. The DHS reactor reduced the HRT of 30 days to 4.8 h compared with the existing algal tank. This result indicates that the DHS reactor could be an appropriate post treatment for the existing anaerobic tank for natural rubber processing wastewater treatment.

  2. Combining UASB and the "fourth generation" down-flow hanging sponge reactor for municipal wastewater treatment.

    PubMed

    Tandukar, M; Uemura, S; Ohashi, A; Harada, H

    2006-01-01

    A "fourth generation" down-flow hanging sponge (DHS) Reactor has been developed and proposed as an improved variant of post-treatment system for UASB treating domestic wastewater. This paper evaluates the potential of the proposed combination of UASB and DHS as a sewage treatment system, especially for developing countries. A pilot-scale UASB (1.15 m3) and DHS (0.38 m3; volume of sponge) was installed in a municipal sewage treatment site and constantly monitored for 2 years. UASB was operated at an HRT of 6 h corresponding to an organic load of 2.15 kg-COD/m3 per day. Subsequently, the organic load in DHS was 2.35 kg-COD/m3 per day, operated at an HRT of 2 h. Organic removal by the whole system was satisfactory, accomplishing 96% of unfiltered BOD removal and 91% of unfiltered COD removal. However, nitrification decreased from 56% during the startup period to 28% afterwards. Investigation on DHS sludge was made by quantifying it and evaluating oxygen uptake rates with various substrates. Average concentration of trapped biomass was 26 g-VSS/L of sponge volume, increasing the SRT of the system to 100-125 d. Removal of coliforms obtained was 3-4 log10 with the final count of 10(3) to 10(4) MPN/100 ml in DHS effluent.

  3. Assessment of UASB-DHS technology for sewage treatment: a comparative study from a sustainability perspective.

    PubMed

    Maharjan, Namita; Nomoto, Naoki; Tagawa, Tadashi; Okubo, Tsutomu; Uemura, Shigeki; Khalil, Nadeem; Hatamoto, Masashi; Yamaguchi, Takashi; Harada, Hideki

    2018-04-06

    This paper assesses the technical and economic sustainability of a combined system of an up-flow anaerobic sludge blanket (UASB)-down-flow hanging sponge (DHS) for sewage treatment. Additionally, this study compares UASB-DHS with current technologies in India like trickling filters (TF), sequencing batch reactor (SBR), moving bed biofilm reactor (MBBR), and other combinations of UASB with post-treatment systems such as final polishing ponds (FPU) and extended aeration sludge process (EASP). The sustainability of the sewage treatment plants (STPs) was evaluated using a composite indicator, which incorporated environmental, societal, and economic dimensions. In case of the individual sustainability indicator study, the results showed that UASB-FPU was the most economically sustainable system with a score of 0.512 and aeration systems such as MBBR, EASP, and SBR were environmentally sustainable, whereas UASB-DHS system was socially sustainable. However, the overall comparative analysis indicated that the UASB-DHS system scored the highest value of 2.619 on the global sustainability indicator followed by EASP and MBBR with scores of 2.322 and 2.279, respectively. The highlight of this study was that the most environmentally sustainable treatment plants were not economically and socially sustainable. Moreover, sensitivity analysis showed that five out of the seven scenarios tested, the UASB-DHS system showed good results amongst the treatment system.

  4. A nitrogen removal system to limit water exchange for recirculating freshwater aquarium using DHS-USB reactor.

    PubMed

    Adlin, Nur; Matsuura, Norihisa; Ohta, Yuki; Hirakata, Yuga; Maki, Shinya; Hatamoto, Masashi; Yamaguchi, Takashi

    2018-06-01

    This study proposes a biological nitrogen removal system for freshwater aquaria consisting of a down-flow hanging sponge (DHS) and an up-flow sludge blanket (USB). DHS-USB systems can perform nitrification and denitrification simultaneously, reducing ammonia (NH 3 ) and nitrate (NO 3 - ) toxicity in the water. The performance of the system was evaluated using on-site fresh water aquaria at ambient temperature (23-34°C) over 192 days. NH 3 and nitrite (NO 2 - ) were maintained at a detection limit of 0.01 mg N L -1 and NO 3 - was maintained below 10 mg N L -1 , despite limited water exchange. The 16S rRNA gene of microorganisms from the sludge retained in the bioreactors was sequenced to identify the microbial communities present. Microbial community analysis revealed that ammonia oxidizing archaea (AOA), Ca. Nitrososphaera and Nitrosopumilus, played an important role in nitrification in the DHS reactor, while denitrifying bacteria Thauera played an important role in denitrification in the USB reactor. The proposed DHS-USB system is a promising technological advancement in the development of lower maintenance aquaria.

  5. 48 CFR 3053.303 - Agency forms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... section illustrates agency-specified forms. To access these forms go to: http://www.dhs.gov (under “Business, Acquisition Information”) or https://dhsonline.dhs.gov/portal/jhtml/general/forms.jhtml. Form...

  6. 48 CFR 3053.303 - Agency forms.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... section illustrates agency-specified forms. To access these forms go to: http://www.dhs.gov (under “Business, Acquisition Information”) or https://dhsonline.dhs.gov/portal/jhtml/general/forms.jhtml. Form...

  7. 48 CFR 3053.303 - Agency forms.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... section illustrates agency-specified forms. To access these forms go to: http://www.dhs.gov (under “Business, Acquisition Information”) or https://dhsonline.dhs.gov/portal/jhtml/general/forms.jhtml. Form...

  8. 48 CFR 3053.303 - Agency forms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... section illustrates agency-specified forms. To access these forms go to: http://www.dhs.gov (under “Business, Acquisition Information”) or https://dhsonline.dhs.gov/portal/jhtml/general/forms.jhtml. Form...

  9. 48 CFR 3053.303 - Agency forms.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... section illustrates agency-specified forms. To access these forms go to: http://www.dhs.gov (under “Business, Acquisition Information”) or https://dhsonline.dhs.gov/portal/jhtml/general/forms.jhtml. Form...

  10. Assessment of a Strategic Partnership Between the U.S. Department of Homeland Security Science and Technology Directorate and the U.S. Army Developmental Test Command

    DTIC Science & Technology

    2011-05-01

    creation of a new material acquisition system. Although the DHS material acquisition system is not fully formed, it is rapidly evolving. Much like...basis to continue or grow in the success of the organization. These strengths can be as tangible as facilities or as intangible as intellectual...reports is the struggle to develop the DHS acquisition workforce. The acquisition workforce in DHS is currently growing , but is only concentrated on

  11. Multi-volatile method for aroma analysis using sequential dynamic headspace sampling with an application to brewed coffee.

    PubMed

    Ochiai, Nobuo; Tsunokawa, Jun; Sasamoto, Kikuo; Hoffmann, Andreas

    2014-12-05

    A novel multi-volatile method (MVM) using sequential dynamic headspace (DHS) sampling for analysis of aroma compounds in aqueous sample was developed. The MVM consists of three different DHS method parameters sets including choice of the replaceable adsorbent trap. The first DHS sampling at 25 °C using a carbon-based adsorbent trap targets very volatile solutes with high vapor pressure (>20 kPa). The second DHS sampling at 25 °C using the same type of carbon-based adsorbent trap targets volatile solutes with moderate vapor pressure (1-20 kPa). The third DHS sampling using a Tenax TA trap at 80 °C targets solutes with low vapor pressure (<1 kPa) and/or hydrophilic characteristics. After the 3 sequential DHS samplings using the same HS vial, the three traps are sequentially desorbed with thermal desorption in reverse order of the DHS sampling and the desorbed compounds are trapped and concentrated in a programmed temperature vaporizing (PTV) inlet and subsequently analyzed in a single GC-MS run. Recoveries of the 21 test aroma compounds for each DHS sampling and the combined MVM procedure were evaluated as a function of vapor pressure in the range of 0.000088-120 kPa. The MVM provided very good recoveries in the range of 91-111%. The method showed good linearity (r2>0.9910) and high sensitivity (limit of detection: 1.0-7.5 ng mL(-1)) even with MS scan mode. The feasibility and benefit of the method was demonstrated with analysis of a wide variety of aroma compounds in brewed coffee. Ten potent aroma compounds from top-note to base-note (acetaldehyde, 2,3-butanedione, 4-ethyl guaiacol, furaneol, guaiacol, 3-methyl butanal, 2,3-pentanedione, 2,3,5-trimethyl pyrazine, vanillin, and 4-vinyl guaiacol) could be identified together with an additional 72 aroma compounds. Thirty compounds including 9 potent aroma compounds were quantified in the range of 74-4300 ng mL(-1) (RSD<10%, n=5). Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  12. Dynamic hydraulic fluid stimulation regulated intramedullary pressure.

    PubMed

    Hu, Minyi; Serra-Hsu, Frederick; Bethel, Neville; Lin, Liangjun; Ferreri, Suzanne; Cheng, Jiqi; Qin, Yi-Xian

    2013-11-01

    Physical signals within the bone, i.e. generated from mechanical loading, have the potential to initiate skeletal adaptation. Strong evidence has pointed to bone fluid flow (BFF) as a media between an external load and the bone cells, in which altered velocity and pressure can ultimately initiate the mechanotransduction and the remodeling process within the bone. Load-induced BFF can be altered by factors such as intramedullary pressure (ImP) and/or bone matrix strain, mediating bone adaptation. Previous studies have shown that BFF induced by ImP alone, with minimum bone strain, can initiate bone remodeling. However, identifying induced ImP dynamics and bone strain factor in vivo using a non-invasive method still remains challenging. To apply ImP as a means for alteration of BFF, it was hypothesized that non-invasive dynamic hydraulic stimulation (DHS) can induce local ImP with minimal bone strain to potentially elicit osteogenic adaptive responses via bone-muscle coupling. The goal of this study was to evaluate the immediate effects on local and distant ImP and strain in response to a range of loading frequencies using DHS. Simultaneous femoral and tibial ImP and bone strain values were measured in three 15-month-old female Sprague Dawley rats during DHS loading on the tibia with frequencies of 1Hz to 10Hz. DHS showed noticeable effects on ImP induction in the stimulated tibia in a nonlinear fashion in response to DHS over the range of loading frequencies, where they peaked at 2Hz. DHS at various loading frequencies generated minimal bone strain in the tibiae. Maximal bone strain measured at all loading frequencies was less than 8με. No detectable induction of ImP or bone strain was observed in the femur. This study suggested that oscillatory DHS may regulate the local fluid dynamics with minimal mechanical strain in the bone, which serves critically in bone adaptation. These results clearly implied DHS's potential as an effective, non-invasive intervention for osteopenia and osteoporosis treatments. © 2013. Published by Elsevier Inc. All rights reserved.

  13. Measuring postnatal care contacts for mothers and newborns: An analysis of data from the MICS and DHS surveys

    PubMed Central

    Amouzou, Agbessi; Mehra, Vrinda; Carvajal–Aguirre, Liliana; Khan, Shane M.; Sitrin, Deborah; Vaz, Lara ME

    2017-01-01

    Background The postnatal period represents a vulnerable phase for mothers and newborns where both face increased risk of morbidity and death. WHO recommends postnatal care (PNC) for mothers and newborns to include a first contact within 24 hours following the birth of the child. However, measuring coverage of PNC in household surveys has been variable over time. The two largest household survey programs in low and middle–income countries, the UNICEF–supported Multiple Indicator Cluster Surveys (MICS) and USAID–funded Demographic and Health Surveys (DHS), now include modules that capture these measures. However, the measurement approach is slightly different between the two programs. We attempt to assess the possible measurement differences that might affect comparability of coverage measures. Methods We first review the standard questionnaires of the two survey programs to compare approaches to collecting data on postnatal contacts for mothers and newborns. We then illustrate how the approaches used can affect PNC coverage estimates by analysing data from four countries; Bangladesh, Ghana, Kygyz Republic, and Nepal, with both MICS and DHS between 2010–2015. Results We found that tools implemented todate by MICS and DHS (up to MICS round 5 and up to DHS phase 6) have collected PNC information in different ways. While MICS dedicated a full module to PNC and distinguishes immediate vs later PNC, DHS implemented a more blended module of pregnancy and postnatal and did not systematically distinguish those phases. The two survey programs differred in the way questions on postnatal care for mothers and newbors were framed. Subsequently, MICS and DHS surveys followed different methodological approach to compute the global indicator of postnatal contacts for mothers and newborns within two days following delivery. Regardless of the place of delivery, MICS estimates for postnatal contacts for mothers and newbors appeared consistently higher than those reported in DHS. The difference was however, far more pronounced in case of newborns. Conclusions Difference in questionnaires and the methodology adopted to measure PNC have created comparability issues in the coverage levels. Harmonization of survey instruments on postnatal contacts will allow comparable and better assessment of coverage levels and trends. PMID:29423179

  14. 77 FR 64818 - The Critical Infrastructure Partnership Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0033] The Critical Infrastructure Partnership... Infrastructure Partnership Advisory Council membership update. SUMMARY: The Department of Homeland Security (DHS) announced the [[Page 64819

  15. Department of Homeland Security

    MedlinePlus

    ... Release Joint Technical Alerts on Malicious North Korean Cyber Activity Today, DHS and FBI released a pair ... María Provide Feedback to DHS Protect Myself from Cyber Attacks Report Cyber Incidents Prepare My Family for ...

  16. How MCM loading and spreading specify eukaryotic DNA replication initiation sites.

    PubMed

    Hyrien, Olivier

    2016-01-01

    DNA replication origins strikingly differ between eukaryotic species and cell types. Origins are localized and can be highly efficient in budding yeast, are randomly located in early fly and frog embryos, which do not transcribe their genomes, and are clustered in broad (10-100 kb) non-transcribed zones, frequently abutting transcribed genes, in mammalian cells. Nonetheless, in all cases, origins are established during the G1-phase of the cell cycle by the loading of double hexamers of the Mcm 2-7 proteins (MCM DHs), the core of the replicative helicase. MCM DH activation in S-phase leads to origin unwinding, polymerase recruitment, and initiation of bidirectional DNA synthesis. Although MCM DHs are initially loaded at sites defined by the binding of the origin recognition complex (ORC), they ultimately bind chromatin in much greater numbers than ORC and only a fraction are activated in any one S-phase. Data suggest that the multiplicity and functional redundancy of MCM DHs provide robustness to the replication process and affect replication time and that MCM DHs can slide along the DNA and spread over large distances around the ORC. Recent studies further show that MCM DHs are displaced along the DNA by collision with transcription complexes but remain functional for initiation after displacement. Therefore, eukaryotic DNA replication relies on intrinsically mobile and flexible origins, a strategy fundamentally different from bacteria but conserved from yeast to human. These properties of MCM DHs likely contribute to the establishment of broad, intergenic replication initiation zones in higher eukaryotes.

  17. Protection of biomass from snail overgrazing in a trickling filter using sponge media as a biomass carrier: down-flow hanging sponge system.

    PubMed

    Onodera, Takashi; Syutsubo, Kazuaki; Yoochatchaval, Wilasinee; Sumino, Haruhiko; Mizuochi, Motoyuki; Harada, Hideki

    2015-01-01

    This study investigated down-flow hanging sponge (DHS) technology as a promising trickling filter (TF) using sponge media as a biomass carrier with an emphasis on protection of the biomass against macrofauna overgrazing. A pilot-scale DHS reactor fed with low-strength municipal sewage was operated under ambient temperature conditions for 1 year at a sewage treatment plant in Bangkok, Thailand. The results showed that snails (macrofauna) were present on the surface of the sponge media, but could not enter into it, because the sponge media with smaller pores physically protected the biomass from the snails. As a result, the sponge media maintained a dense biomass, with an average value of 22.3 gVSS/L sponge (58.1 gTSS/L sponge) on day 370. The snails could graze biomass on the surface of the sponge media. The DHS reactor process performance was also successful. The DHS reactor requires neither chemical treatments nor specific operations such as flooding for snail control. Overall, the results of this study indicate that the DHS reactor is able to protect biomass from snail overgrazing.

  18. 76 FR 32331 - Preliminary Plan for Retrospective Review of Existing Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ... review. In addition, DHS launched an IdeaScale Web page; this social media tool provided an additional... agency's regulatory program more effective or less burdensome in achieving its regulatory objectives. DHS...

  19. 77 FR 37685 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... familiar with the data privacy- related issues addressed by small to medium enterprises; and 3. Other... within or outside the agency. In certain circumstances, DHS may share this information on a case-by-case...

  20. 77 FR 26023 - President's National Security Telecommunications Advisory Committee; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0016] President's National Security Telecommunications Advisory Committee; Correction AGENCY: National Protection and Programs Directorate, DHS. [[Page... April 25, 2012, concerning the President's National Security Telecommunications Advisory Committee...

  1. 5 CFR 9701.410 - DHS responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its...

  2. A hybrid dynamic harmony search algorithm for identical parallel machines scheduling

    NASA Astrophysics Data System (ADS)

    Chen, Jing; Pan, Quan-Ke; Wang, Ling; Li, Jun-Qing

    2012-02-01

    In this article, a dynamic harmony search (DHS) algorithm is proposed for the identical parallel machines scheduling problem with the objective to minimize makespan. First, an encoding scheme based on a list scheduling rule is developed to convert the continuous harmony vectors to discrete job assignments. Second, the whole harmony memory (HM) is divided into multiple small-sized sub-HMs, and each sub-HM performs evolution independently and exchanges information with others periodically by using a regrouping schedule. Third, a novel improvisation process is applied to generate a new harmony by making use of the information of harmony vectors in each sub-HM. Moreover, a local search strategy is presented and incorporated into the DHS algorithm to find promising solutions. Simulation results show that the hybrid DHS (DHS_LS) is very competitive in comparison to its competitors in terms of mean performance and average computational time.

  3. pDHS-SVM: A prediction method for plant DNase I hypersensitive sites based on support vector machine.

    PubMed

    Zhang, Shanxin; Zhou, Zhiping; Chen, Xinmeng; Hu, Yong; Yang, Lindong

    2017-08-07

    DNase I hypersensitive sites (DHSs) are accessible chromatin regions hypersensitive to cleavages by DNase I endonucleases. DHSs are indicative of cis-regulatory DNA elements (CREs), all of which play important roles in global gene expression regulation. It is helpful for discovering CREs by recognition of DHSs in genome. To accelerate the investigation, it is an important complement to develop cost-effective computational methods to identify DHSs. However, there is a lack of tools used for identifying DHSs in plant genome. Here we presented pDHS-SVM, a computational predictor to identify plant DHSs. To integrate the global sequence-order information and local DNA properties, reverse complement kmer and dinucleotide-based auto covariance of DNA sequences were applied to construct the feature space. In this work, fifteen physical-chemical properties of dinucleotides were used and Support Vector Machine (SVM) was employed. To further improve the performance of the predictor and extract an optimized subset of nucleotide physical-chemical properties positive for the DHSs, a heuristic nucleotide physical-chemical property selection algorithm was introduced. With the optimized subset of properties, experimental results of Arabidopsis thaliana and rice (Oryza sativa) showed that pDHS-SVM could achieve accuracies up to 87.00%, and 85.79%, respectively. The results indicated the effectiveness of proposed method for predicting DHSs. Furthermore, pDHS-SVM could provide a helpful complement for predicting CREs in plant genome. Our implementation of the novel proposed method pDHS-SVM is freely available as source code, at https://github.com/shanxinzhang/pDHS-SVM. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Specific Location of Disc Hemorrhage is Linked to Nerve Fiber Layer Defects.

    PubMed

    Yoo, Young Cheol; Kim, Joon Mo; Park, Han Seok; Yoo, Chungkwon; Shim, Seong Hee; Won, Yu Sam; Park, Ki Ho; Chang, Robert T

    2017-06-01

    To investigate the relationship between retinal nerve fiber layer (RNFL) defects and the quadrant and proximal location of disc hemorrhages (DHs) in a large population examined for health screening. A total of 168,044 subjects older than 20 years underwent a single screening ophthalmic examination with color fundus photography as part of a comprehensive health screening program. The presence and location of DHs and RNFL defects were assessed. The DH locations were defined according to the quadrant location (inferotemporal, superotemporal, inferonasal, or superonasal) and the most proximal end of DHs relative to the disc center (cup base, cup margin, disc rim, or extrapapillary region). Using these two location descriptors as independent variables, a logistic regression analysis was conducted to explore the effects of DH location on RNFL defects. Two hundred twenty-six eyes had DH and 120 (53.1%) of them had RNFL defects. After adjusting for proximal location, DHs located in the inferotemporal quadrant accompanied RFNL defects 12 times more frequently than those in the superonasal quadrant (odds ratio [OR], 11.81; P = .004). Conversely, after adjusting for quadrant location, the ORs for an associated RNFL defect were 3.73 (P < .001), 16.54 (P < .001), and 8.91 (P = .002) for DHs with the proximal end at the disc rim, cup margin, and cup base, respectively. Among the four quadrants and four proximal locations, DHs were identified most frequently in the inferotemporal quadrant and outside the disc, respectively. Some DH locations, such as the inferotemporal quadrant and the cup margin, were associated with RNFL defects, whereas others were not.

  5. How MCM loading and spreading specify eukaryotic DNA replication initiation sites

    PubMed Central

    Hyrien, Olivier

    2016-01-01

    DNA replication origins strikingly differ between eukaryotic species and cell types. Origins are localized and can be highly efficient in budding yeast, are randomly located in early fly and frog embryos, which do not transcribe their genomes, and are clustered in broad (10-100 kb) non-transcribed zones, frequently abutting transcribed genes, in mammalian cells. Nonetheless, in all cases, origins are established during the G1-phase of the cell cycle by the loading of double hexamers of the Mcm 2-7 proteins (MCM DHs), the core of the replicative helicase. MCM DH activation in S-phase leads to origin unwinding, polymerase recruitment, and initiation of bidirectional DNA synthesis. Although MCM DHs are initially loaded at sites defined by the binding of the origin recognition complex (ORC), they ultimately bind chromatin in much greater numbers than ORC and only a fraction are activated in any one S-phase. Data suggest that the multiplicity and functional redundancy of MCM DHs provide robustness to the replication process and affect replication time and that MCM DHs can slide along the DNA and spread over large distances around the ORC. Recent studies further show that MCM DHs are displaced along the DNA by collision with transcription complexes but remain functional for initiation after displacement. Therefore, eukaryotic DNA replication relies on intrinsically mobile and flexible origins, a strategy fundamentally different from bacteria but conserved from yeast to human. These properties of MCM DHs likely contribute to the establishment of broad, intergenic replication initiation zones in higher eukaryotes. PMID:27635237

  6. 75 FR 32798 - Directorate for Management; DHS Diversity Forum: Building a Community for Women in the Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    .... DHS is committed to making the vision of a fully representative workforce a reality. Procedural: This...: Individuals requiring reasonable accommodations or alternate formats are asked to submit their requests to...

  7. 76 FR 39406 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... at least one individual who is familiar with the data concerns of small to medium enterprises; and 3... certain circumstances, DHS may share this information on a case-by-case basis as required by law or as...

  8. 78 FR 29145 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2013-0022] President's National Security Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... notice of a May 22, 2013, meeting of the President's National Security Telecommunications Advisory...

  9. 5 CFR 9701.314 - DHS responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9701.314 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Pay and Pay Administration Overview of Pay System § 9701.314 DHS...

  10. 75 FR 28051 - Intent To Request Renewal From OMB of One Current Public Collection of Information: Department of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... Immigration Services (CIS), U.S. Immigration and Customs Enforcement (ICE), U.S. Visitor and Immigration Status Indicator Technology (US-VISIT), DHS Office of Civil Rights and Civil Liberties (CRCL), DHS...

  11. 76 FR 41273 - National Emergency Communications Plan (NECP) Tribal Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0025] National Emergency Communications Plan... Communications (CS&C), Office of Emergency Communications (OEC), will submit the following information collection... concerning New Information Collection Request, National Emergency Communications Plan Tribal Report. DHS...

  12. 76 FR 14678 - Communications Unit Leader Prerequisite and Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0004] Communications Unit Leader Prerequisite... Security (DHS), National Protection and Programs Directorate (NPPD), Cybersecurity and Communications (CS&C), Office of Emergency Communications (OEC) will submit the following information collection request to the...

  13. 6 CFR 7.11 - Components' responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INFORMATION Administration § 7.11 Components' responsibilities. Each DHS component shall appoint a security... security information; (b) Report violations of the provisions of this regulation to the Chief Security... component acquire adequate security education and training, as required by the DHS classified information...

  14. 78 FR 16861 - The Critical Infrastructure Partnership Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0077] The Critical Infrastructure Partnership... Infrastructure Partnership Advisory Council membership update. SUMMARY: The Department of Homeland Security (DHS) announced the establishment of the Critical Infrastructure Partnership Advisory Council (CIPAC) in a Federal...

  15. Recovery and biological oxidation of dissolved methane in effluent from UASB treatment of municipal sewage using a two-stage closed downflow hanging sponge system.

    PubMed

    Matsuura, Norihisa; Hatamoto, Masashi; Sumino, Haruhiko; Syutsubo, Kazuaki; Yamaguchi, Takashi; Ohashi, Akiyoshi

    2015-03-15

    A two-stage closed downflow hanging sponge (DHS) reactor was used as a post-treatment to prevent methane being emitted from upflow anaerobic sludge blanket (UASB) effluents containing unrecovered dissolved methane. The performance of the closed DHS reactor was evaluated using real municipal sewage at ambient temperatures (10-28 °C) for one year. The first stage of the closed DHS reactor was intended to recover dissolved methane from the UASB effluent and produce a burnable gas with a methane concentration greater than 30%, and its recovery efficiency was 57-88%, although the amount of dissolved methane in the UASB effluent fluctuated in the range of 46-68 % of methane production greatly depending on the temperature. The residual methane was oxidized and the remaining organic carbon was removed in the second closed DHS reactor, and this reactor performed very well, removing more than 99% of the dissolved methane during the experimental period. The rate at which air was supplied to the DHS reactor was found to be one of the most important operating parameters. Microbial community analysis revealed that seasonal changes in the methane-oxidizing bacteria were key to preventing methane emissions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. 76 FR 50487 - Protected Critical Infrastructure Information (PCII) Stakeholder Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... Information (PCII) Stakeholder Survey AGENCY: National Protection and Programs Directorate, DHS. ACTION: 30... Collection Request, Protected Critical Infrastructure Information (PCII) Stakeholder Survey. DHS previously... homeland security duties. This survey is designed to gather information from PCII Officers that can be used...

  17. 78 FR 20119 - Broad Stakeholder Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0042] Broad Stakeholder Survey AGENCY... concerning the Broad Stakeholder Survey. DHS previously published this ICR in the Federal Register on August... across the Nation. The Broad Stakeholder Survey is designed to gather stakeholder feedback on the...

  18. 75 FR 69688 - Agency Information Collection Activities: Regulation on Agency Protests

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ... Protests AGENCY: Office of Chief Procurement Officer, Acquisition Policy and Legislation Office, DHS... Department of Homeland Security, Office of Chief Procurement Officer, Acquisition Policy and Legislation..., Acquisition Policy and Legislation Office, DHS Attn.: Camara Francis, Department of Homeland Security, Office...

  19. 78 FR 34665 - Homeland Security Information Network Advisory Committee (HSINAC); Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... DEPARTMENT OF HOMELAND SECURITY [DHS-2013-0037] Homeland Security Information Network Advisory... Committee Meeting. SUMMARY: The Homeland Security Information Network Advisory Committee (HSINAC) will meet... posted beforehand at this link: http://www.dhs.gov/homeland-security-information-network-advisory...

  20. 75 FR 68370 - Agency Information Collection Activities: Office of Infrastructure Protection; Chemical Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... DEPARTMENT OF HOMELAND SECURITY National Protection and Programs Directorate [Docket No. DHS-2010-0071] Agency Information Collection Activities: Office of Infrastructure Protection; Chemical Security...: The Department of Homeland Security (DHS), National Protection and Programs Directorate (NPPD), Office...

  1. Health determining concepts important to people with Crohn's disease and their coverage by patient-reported outcomes of health and wellbeing☆☆☆

    PubMed Central

    Dür, Mona; Sadloňová, Martina; Haider, Stefanie; Binder, Alexa; Stoffer, Michaela; Coenen, Michaela; Smolen, Josef; Dejaco, Clemens; Kautzky-Willer, Alexandra; Fialka-Moser, Veronika; Moser, Gabriele; Stamm, Tanja Alexandra

    2014-01-01

    Background and aims Busy clinical settings often restrict the possibility to focus on concepts that determine health in a positive way, commonly assessed by using patient-reported outcomes (PROs). We aimed to explore which determinants of health (DHs) are important to people with Crohn's disease (CD), to understand possible gender differences and to analyze whether these DHs are covered by PROs used in CD. Methods Two systematic literature reviews were done to identify relevant DHs and clinically relevant PROs. We conducted a qualitative narrative biographical study and mapped the patients' experiences to concepts that determine health in a positive way. Experiences, DHs and the items of the PROs were compared by the WHO International Classification of Functioning, Disability and Health (ICF) as a common framework. Results 15 people with CD with a median age of 46 years (IQR 34–60) and median disease duration of 15 years (IQR 8–30) participated. Self-efficacy, social support, job satisfaction and occupational balance were mentioned most frequently. While participation appeared to have greater meaning to men, appreciation and resilience seemed to be more important for women. Of 18 PROs the Perceived Stress Questionnaire (PSQ), the Inflammatory Bowel disease — Self-efficacy scale (IBD-SES), the Life Orientation Test — Revised (LOT-R) and the Patient Activation Measure 13 (PAM-13) cover most DHs. Conclusions This is the first study elaborating the coverage of patient's perspective by commonly used PROs in CD. The findings could support health professionals to focus on DHs in people with CD in clinical practice and research. PMID:23375212

  2. A Dental Hygiene Professional Practice Index (DHPPI) and access to oral health status and service use in the United States.

    PubMed

    Wing, Paul; Langelier, Margaret H; Continelli, Tracey A; Battrell, Ann

    2005-01-01

    The purpose of this article is to summarize a larger study that developed a statistical index that defines the professional practice environment of dental hygienists (DHs) in the United States, and to determine the extent to which the index scores are related to the number of DHs and dentists, the utilization of dental services, and selected oral health outcomes across the 50 states. A Dental Hygiene Professional Practice Index (DHPPI) defines the professional status, supervision requirements, tasks permitted, and reimbursement options for DHs in each of the 50 states and the District of Columbia, as of December 31, 2001. Spearman rank order correlations between the DHPPI and numbers of oral health professionals, utilization of oral health services, and oral health outcomes in the 50 states are also presented. The analyses revealed that: There are significant differences in the legal practice environments (as reflected in the DHPPI) across the 50 states and the District of Columbia. Between 1990 and 2001, the number of DHs per capita increased by 46% in the United States, while the number of dentists per 100,000 population increased by only 10%. The DHPPI was not significantly correlated with the number of DHs or dentists in the 50 states in 2001. The DHPPI was significantly positively correlated with the salaries of DHs in 2001. The DHPPI was also significantly and positively correlated with a number of indicators of utilization of oral health services and oral health outcomes. Both access to oral health services and oral health outcomes are positively correlated with the DHPPI. This suggests that states with low DHPPI scores would be logical candidates for revised DH practice statutes and regulations to accomplish these objectives.

  3. Anti-Cancer Efficacy of Silybin Derivatives - A Structure-Activity Relationship

    PubMed Central

    Agarwal, Chapla; Wadhwa, Ritambhara; Deep, Gagan; Biedermann, David; Gažák, Radek; Křen, Vladimír; Agarwal, Rajesh

    2013-01-01

    Silybin or silibinin, a flavonolignan isolated from Milk thistle seeds, is one of the popular dietary supplements and has been extensively studied for its antioxidant, hepatoprotective and anti-cancer properties. We have envisioned that potency of silybin could be further enhanced through suitable modification/s in its chemical structure. Accordingly, here, we synthesized and characterized a series of silybin derivatives namely 2,3-dehydrosilybin (DHS), 7-O-methylsilybin (7OM), 7-O-galloylsilybin (7OG), 7,23-disulphatesilybin (DSS), 7-O-palmitoylsilybin (7OP), and 23-O-palmitoylsilybin (23OP); and compared their anti-cancer efficacy using human bladder cancer HTB9, colon cancer HCT116 and prostate carcinoma PC3 cells. In all the 3 cell lines, DHS, 7OM and 7OG demonstrated better growth inhibitory effects and compared to silybin, while other silybin derivatives showed lesser or no efficacy. Next, we prepared the optical isomers (A and B) of silybin, DHS, 7OM and 7OG, and compared their anti-cancer efficacy. Isomers of these three silybin derivatives also showed better efficacy compared with respective silybin isomers, but in each, there was no clear cut silybin A versus B isomer activity preference. Further studies in HTB cells found that DHS, 7OM and 7OG exert better apoptotic activity than silibinin. Clonogenic assays in HTB9 cells further confirmed that both the racemic mixtures as well as pure optical isomers of DHS, 7OM and 7OG were more effective than silybin. Overall, these results clearly suggest that the anti-cancer efficacy of silybin could be significantly enhanced through structural modifications, and identify strong anti-cancer efficacy of silybin derivatives, namely DHS, 7OM, and 7OG, signifying that their efficacy and toxicity should be evaluated in relevant pre-clinical cancer models in rodents. PMID:23555889

  4. 75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0040] Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

  5. 76 FR 68486 - Agency Information Collection Activities: Submission for Review; Information Collection Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0077] Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS), Science and Technology, External S&T Collaboration Site (E-STCS) AGENCY: Science and Technology...

  6. 75 FR 53706 - Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0072] Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

  7. 77 FR 5681 - Establishment of Global Entry Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... Joint Declaration between DHS and the Secretariat of Governance of the United Mexican States, through... Global Entry, including airlines, hotels, travel and tourism companies, national business travelers... Nationals DHS, through CBP, has issued a Joint Declaration with the Secretariat of Governance of the United...

  8. 78 FR 29375 - Protected Critical Infrastructure Information (PCII) Office Self-Assessment Questionnaire

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ...), Office of Infrastructure Protection (IP), Infrastructure Information Collection Division (IICD... Forrest DHS/NPPD/IP/PCII, [email protected] . SUPPLEMENTARY INFORMATION: The PCII Program was... administered by DHS/ NPPD/IP/IICD. The PCII Program is responsible for ensuring compliance with the Regulation...

  9. A secure image encryption method based on dynamic harmony search (DHS) combined with chaotic map

    NASA Astrophysics Data System (ADS)

    Mirzaei Talarposhti, Khadijeh; Khaki Jamei, Mehrzad

    2016-06-01

    In recent years, there has been increasing interest in the security of digital images. This study focuses on the gray scale image encryption using dynamic harmony search (DHS). In this research, first, a chaotic map is used to create cipher images, and then the maximum entropy and minimum correlation coefficient is obtained by applying a harmony search algorithm on them. This process is divided into two steps. In the first step, the diffusion of a plain image using DHS to maximize the entropy as a fitness function will be performed. However, in the second step, a horizontal and vertical permutation will be applied on the best cipher image, which is obtained in the previous step. Additionally, DHS has been used to minimize the correlation coefficient as a fitness function in the second step. The simulation results have shown that by using the proposed method, the maximum entropy and the minimum correlation coefficient, which are approximately 7.9998 and 0.0001, respectively, have been obtained.

  10. DKIST visible broadband imager data processing pipeline

    NASA Astrophysics Data System (ADS)

    Beard, Andrew; Cowan, Bruce; Ferayorni, Andrew

    2014-07-01

    The Daniel K. Inouye Solar Telescope (DKIST) Data Handling System (DHS) provides the technical framework and building blocks for developing on-summit instrument quality assurance and data reduction pipelines. The DKIST Visible Broadband Imager (VBI) is a first light instrument that alone will create two data streams with a bandwidth of 960 MB/s each. The high data rate and data volume of the VBI require near-real time processing capability for quality assurance and data reduction, and will be performed on-summit using Graphics Processing Unit (GPU) technology. The VBI data processing pipeline (DPP) is the first designed and developed using the DKIST DHS components, and therefore provides insight into the strengths and weaknesses of the framework. In this paper we lay out the design of the VBI DPP, examine how the underlying DKIST DHS components are utilized, and discuss how integration of the DHS framework with GPUs was accomplished. We present our results of the VBI DPP alpha release implementation of the calibration, frame selection reduction, and quality assurance display processing nodes.

  11. Microbial Monitoring from the Frontlines to Space: Department of Defense Small Business Innovation Research Technology Aboard the International Space Station

    NASA Technical Reports Server (NTRS)

    Oubre, Cherie M.; Khodadad, Christina L.; Castro, Victoria A.; Ott, C. Mark; Flint, Stephanie; Pollack, Lawrence P.; Roman, Monserrate C.

    2017-01-01

    The RAZOR (trademark) EX, a quantitative Polymerase Chain Reaction (qPCR) instrument, is a portable, ruggedized unit that was designed for the Department of Defense (DoD) with its reagent chemistries traceable to a Small Business Innovation Research (SBIR) contract beginning in 2002. The PCR instrument's primary function post 9/11 was to enable frontline soldiers and first responders to detect biological threat agents and bioterrorism activities in remote locations to include field environments. With its success for DoD, the instrument has also been employed by other governmental agencies including Department of Homeland Security (DHS). The RAZOR (Trademark) EX underwent stringent testing by the vendor, as well as through the DoD, and was certified in 2005. In addition, the RAZOR (trademark) EX passed DHS security sponsored Stakeholder Panel on Agent Detection Assays (SPADA) rigorous evaluation in 2011. The identification and quantitation of microbial pathogens is necessary both on the ground as well as during spaceflight to maintain the health of astronauts and to prevent biofouling of equipment. Currently, culture-based monitoring technology has been adequate for short-term spaceflight missions but may not be robust enough to meet the requirements for long-duration missions. During a NASA-sponsored workshop in 2011, it was determined that the more traditional culture-based method should be replaced or supplemented with more robust technologies. NASA scientists began investigating innovative molecular technologies for future space exploration and as a result, PCR was recommended. Shortly after, NASA sponsored market research in 2012 to identify and review current, commercial, cutting edge PCR technologies for potential applicability to spaceflight operations. Scientists identified and extensively evaluated three candidate technologies with the potential to function in microgravity. After a thorough voice-of-the-customer trade study and extensive functional and safety evaluations, the RAZOR (trademark) EX PCR instrument(Bio-Fire Defense, Salt Lake City, UT) was selected as the most promising current technology for spaceflight monitoring applications.

  12. Measuring Coverage in MNCH: A Prospective Validation Study in Pakistan and Bangladesh on Measuring Correct Treatment of Childhood Pneumonia

    PubMed Central

    el Arifeen, Shams; Khan, Amira M.; Huque, M. Hamidul; Kazmi, Narjis; Roy, Sushmita; Abbasi, Saleem; Rahman, Qazi Sadeq-ur; Theodoratou, Evropi; Khorshed, Mahmuda Shayema; Rahman, Kazi Mizanur; Bari, Sanwarul; Kaiser, M. Mahfuzul Islam; Saha, Samir K.; Ahmed, A. S. M. Nawshad Uddin; Rudan, Igor; Bryce, Jennifer; Qazi, Shamim Ahmad; Campbell, Harry

    2013-01-01

    Background Antibiotic treatment for pneumonia as measured by Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS) is a key indicator for tracking progress in achieving Millennium Development Goal 4. Concerns about the validity of this indicator led us to perform an evaluation in urban and rural settings in Pakistan and Bangladesh. Methods and Findings Caregivers of 950 children under 5 y with pneumonia and 980 with “no pneumonia” were identified in urban and rural settings and allocated for DHS/MICS questions 2 or 4 wk later. Study physicians assigned a diagnosis of pneumonia as reference standard; the predictive ability of DHS/MICS questions and additional measurement tools to identify pneumonia versus non-pneumonia cases was evaluated. Results at both sites showed suboptimal discriminative power, with no difference between 2- or 4-wk recall. Individual patterns of sensitivity and specificity varied substantially across study sites (sensitivity 66.9% and 45.5%, and specificity 68.8% and 69.5%, for DHS in Pakistan and Bangladesh, respectively). Prescribed antibiotics for pneumonia were correctly recalled by about two-thirds of caregivers using DHS questions, increasing to 72% and 82% in Pakistan and Bangladesh, respectively, using a drug chart and detailed enquiry. Conclusions Monitoring antibiotic treatment of pneumonia is essential for national and global programs. Current (DHS/MICS questions) and proposed new (video and pneumonia score) methods of identifying pneumonia based on maternal recall discriminate poorly between pneumonia and children with cough. Furthermore, these methods have a low yield to identify children who have true pneumonia. Reported antibiotic treatment rates among these children are therefore not a valid proxy indicator of pneumonia treatment rates. These results have important implications for program monitoring and suggest that data in its current format from DHS/MICS surveys should not be used for the purpose of monitoring antibiotic treatment rates in children with pneumonia at the present time. Please see later in the article for the Editors' Summary PMID:23667339

  13. Challenges of DHS and MIS to capture the entire pattern of malaria parasite risk and intervention effects in countries with different ecological zones: the case of Cameroon.

    PubMed

    Massoda Tonye, Salomon G; Kouambeng, Celestin; Wounang, Romain; Vounatsou, Penelope

    2018-04-06

    In 2011, the demographic and health survey (DHS) in Cameroon was combined with the multiple indicator cluster survey. Malaria parasitological data were collected, but the survey period did not overlap with the high malaria transmission season. A malaria indicator survey (MIS) was also conducted during the same year, within the malaria peak transmission season. This study compares estimates of the geographical distribution of malaria parasite risk and of the effects of interventions obtained from the DHS and MIS survey data. Bayesian geostatistical models were applied on DHS and MIS data to obtain georeferenced estimates of the malaria parasite prevalence and to assess the effects of interventions. Climatic predictors were retrieved from satellite sources. Geostatistical variable selection was used to identify the most important climatic predictors and indicators of malaria interventions. The overall observed malaria parasite risk among children was 33 and 30% in the DHS and MIS data, respectively. Both datasets identified the Normalized Difference Vegetation Index and the altitude as important predictors of the geographical distribution of the disease. However, MIS selected additional climatic factors as important disease predictors. The magnitude of the estimated malaria parasite risk at national level was similar in both surveys. Nevertheless, DHS estimates lower risk in the North and Coastal areas. MIS did not find any important intervention effects, although DHS revealed that the proportion of population with an insecticide-treated nets access in their household was statistically important. An important negative relationship between malaria parasitaemia and socioeconomic factors, such as the level of mother's education, place of residence and the household welfare were captured by both surveys. Timing of the malaria survey influences estimates of the geographical distribution of disease risk, especially in settings with seasonal transmission. In countries with different ecological zones and thus different seasonal patterns, a single survey may not be able to identify all high risk areas. A continuous MIS or a combination of MIS, health information system data and data from sentinel sites may be able to capture the disease risk distribution in space across different seasons.

  14. Adolescent fertility and family planning in East Asia and the Pacific: a review of DHS reports

    PubMed Central

    2011-01-01

    Background Adolescent pregnancy has significant health and socio-economic consequences for women, their families and communities. Efforts to prevent too-early pregnancy rely on accurate information about adolescents' knowledge, behaviours and access to family planning, however available data are limited in some settings. Demographic and Health Survey (DHS) reports are recognised as providing nationally representative data that are accessible to policymakers and programmers. This paper reviews DHS reports for low and lower middle income countries in East Asia and the Pacific to determine what information regarding adolescent fertility and family planning is available, and summarises key findings. Methods The most recent DHS reports were sought for the 33 low and lower middle income countries in the East Asia and Pacific region as defined by UNICEF and World Bank. Age-disaggregated data for all indicators relevant to fertility and current use, knowledge and access to family planning information and services were sought to identify accessible information. Reported data were analysed using an Excel database to determine outcomes for adolescents and compare with adult women. Results DHS reports were available for eleven countries: Cambodia, Indonesia, Marshall Islands, Nauru, Papua New Guinea, Philippines, Samoa, Solomon Islands, Timor-Leste, Tuvalu and Vietnam. Twenty seven of 40 relevant DHS indicators reported outcomes for adolescent women aged 15-19 years. There were limited data for unmarried adolescents. A significant proportion of women commence sexual activity and childbearing during adolescence in the context of low contraceptive prevalence and high unmet need for contraception. Adolescent women have lower use of contraception, poorer knowledge of family planning and less access to information and services than adult women. Conclusion DHS reports provide useful and accessible data, however, they are limited by the failure to report data for unmarried adolescents and report age-disaggregated data for some indicators. Further research is required to better understand the barriers that both married and unmarried adolescents face accessing reproductive health information and services, and their information and service delivery preferences. PMID:21545708

  15. GPS disruptions : efforts to assess risks to critical infrastructure and coordinate agency actions should be enhanced.

    DOT National Transportation Integrated Search

    2013-11-01

    To assess the risks and potential effects from disruptions in the Global : Positioning System (GPS) on critical infrastructure, the Department of Homeland : Security (DHS) published the GPS National Risk Estimate (NRE) in 2012. In : doing so, DHS con...

  16. 75 FR 16491 - Science and Technology Directorate; Submission for Review; Information Collection Request for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0026] Science and Technology Directorate; Submission for Review; Information Collection Request for the Department of Homeland Security Science and Technology Directorate First Responders Community of Practice AGENCY: Science and Technology Directorate, DHS...

  17. 49 CFR 1507.3 - Exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... exempt from the access provisions of subsection (d). (e) Correspondence and Matters Tracking Records (DHS/TSA 006). The Correspondence and Matters Tracking Records (CMTR) (DHS/TSA 006) system allows TSA to... is not always possible for TSA or other agencies to know in advance what information is both relevant...

  18. 5 CFR 9701.405 - Performance management system requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Performance management system...

  19. 5 CFR 9701.405 - Performance management system requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Performance management system...

  20. 5 CFR 9701.405 - Performance management system requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Performance management system...

  1. 5 CFR 9701.405 - Performance management system requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Performance management system...

  2. 8 CFR 212.15 - Certificates for foreign health care workers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... for authorization to issue such certificates. The DHS will evaluate CGFNS' expertise with respect to... 8 CFR 103.3. (k) Standards for credentialing organizations. The DHS will evaluate organizations... resources to conduct the program(s) including the authority to approve selection of, evaluate, and initiate...

  3. 8 CFR 212.15 - Certificates for foreign health care workers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for authorization to issue such certificates. The DHS will evaluate CGFNS' expertise with respect to... 8 CFR 103.3. (k) Standards for credentialing organizations. The DHS will evaluate organizations... resources to conduct the program(s) including the authority to approve selection of, evaluate, and initiate...

  4. 8 CFR 212.15 - Certificates for foreign health care workers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for authorization to issue such certificates. The DHS will evaluate CGFNS' expertise with respect to... 8 CFR 103.3. (k) Standards for credentialing organizations. The DHS will evaluate organizations... resources to conduct the program(s) including the authority to approve selection of, evaluate, and initiate...

  5. 78 FR 14101 - Homeland Security Science and Technology Advisory Committee (HSSTAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Technology Advisory Committee (HSSTAC) AGENCY: Science and Technology Directorate, DHS. ACTION: Committee... Technology Advisory Committee (HSSTAC) will meet on March 21, 2013 in Washington, DC The meeting will be open... the Department of Homeland Security (DHS), Science and Technology Directorate, 1120 Vermont Avenue NW...

  6. DOE/DHS/DOT Volpe Technical Meeting on Electric Vehicle and Charging Station Cybersecurity Report

    DOT National Transportation Integrated Search

    2018-03-26

    On November 29-30, 2017, the U.S. Department of Energys (DOE) Office of Policy (OP), in collaboration with DOEs Vehicle Technology Office (VTO), the U.S. Department of Homeland Securitys (DHS) Science and Technology Directorate (S&T) Cyber S...

  7. 78 FR 69100 - Agency Information Collection Activities: Proposed Collection; Comment Request; Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2013-0045... AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency... written comments to Regulatory Affairs Division, Office of Chief Counsel, DHS/FEMA, 500 C Street SW., Room...

  8. 76 FR 50811 - Seventeenth Meeting: EUROCAE WG-72: RTCA Special Committee 216: Aeronautical Systems Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    .... Agenda Tuesday, September 6th (Pre-Meeting Events) 9 a.m. to 12 p.m. Optional--DHS National Cybersecurity... cooperation. 11:15 a.m.-12 p.m., DHS Briefing on the Cybersecurity Control System Security (CSSP) Program. 1 p...

  9. Photodegradation of 17α-ethynylestradiol in dissolved humic substances solution: Kinetics, mechanism and estrogenicity variation.

    PubMed

    Ren, Dong; Huang, Bin; Xiong, Dan; He, Huan; Meng, Xiangqi; Pan, Xuejun

    2017-04-01

    17α-Ethynylestradiol (EE2) in natural waters may cause adverse effects on organisms due to its high estrogenic potency. Laboratory studies were performed to study the effects of a local humic acid (LHA), fulvic acid (LFA) and Aldrich humic acid (AHA) on the photochemical behavior and estrogenic potency of EE2. Here photolytic experiments demonstrated that pure aqueous EE2 could undergo direct and self-sensitized photodegradation at a global rate of 0.0068hr -1 . Photodegradation rate of EE2 in 5.0mg/L dissolved humic substances (DHS) was determined to be 0.0274, 0.0296 and 0.0254hr -1 for LHA, LFA and AHA, respectively. Reactive oxygen species (ROS) and triplet dissolved humic substances ( 3 DHS*) scavenging experiments indicated that the promotion effect of DHS on EE2 photodegradation was mainly aroused by the reactions of HO (35%-50%), 1 O 2 (<10%) and 3 DHS* (22%-34%). However, the photodegradation of EE2 could also be inhibited when DHS exceeded the threshold of 10mg/L. Three hydroxylation products of EE2 were identified using GC-MS and their formation pathways were also proposed. In vitro estrogenicity tests showed that EE2 was transformed into chemicals without estrogenic potency. These findings could extend our knowledge on the photochemical behaviors of steroid estrogens in sunlit natural waters. Copyright © 2016. Published by Elsevier B.V.

  10. Extensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection

    PubMed Central

    Fedrigo, Olivier; Babbitt, Courtney C.; Wortham, Matthew; Tewari, Alok K.; London, Darin; Song, Lingyun; Lee, Bum-Kyu; Iyer, Vishwanath R.; Parker, Stephen C. J.; Margulies, Elliott H.; Wray, Gregory A.; Furey, Terrence S.; Crawford, Gregory E.

    2012-01-01

    Understanding the molecular basis for phenotypic differences between humans and other primates remains an outstanding challenge. Mutations in non-coding regulatory DNA that alter gene expression have been hypothesized as a key driver of these phenotypic differences. This has been supported by differential gene expression analyses in general, but not by the identification of specific regulatory elements responsible for changes in transcription and phenotype. To identify the genetic source of regulatory differences, we mapped DNaseI hypersensitive (DHS) sites, which mark all types of active gene regulatory elements, genome-wide in the same cell type isolated from human, chimpanzee, and macaque. Most DHS sites were conserved among all three species, as expected based on their central role in regulating transcription. However, we found evidence that several hundred DHS sites were gained or lost on the lineages leading to modern human and chimpanzee. Species-specific DHS site gains are enriched near differentially expressed genes, are positively correlated with increased transcription, show evidence of branch-specific positive selection, and overlap with active chromatin marks. Species-specific sequence differences in transcription factor motifs found within these DHS sites are linked with species-specific changes in chromatin accessibility. Together, these indicate that the regulatory elements identified here are genetic contributors to transcriptional and phenotypic differences among primate species. PMID:22761590

  11. Chemical characterization of fractions of dissolved humic substances from a marginal sea—a case from the Southern Yellow Sea

    NASA Astrophysics Data System (ADS)

    Zhang, Yaoling; Yang, Keli; Du, Jinzhou; Zhang, Fenfen; Dong, Yaping; Li, Wu

    2018-03-01

    Marine dissolved organic matter (DOM) is one of the largest dynamic pools of organic carbon in the global carbon cycle, yet DOM is still chemically poorly characterized. To better understand the origin, composition, and cycling of DOM in the China marginal sea, dissolved humic substances (DHS) were isolated from seawaters in two locations in the Southern Yellow Sea. The DHS were subdivided into fulvic acids (FAs), humic acids (HAs) and the XAD-4 fractions. Complementary analytical approaches were used to characterize the isolated DHS samples including stable carbon isotopic composition, Fourier transform infrared spectroscopy (FTIR), 13C cross polarization magic angle spinning (CP/MAS) nuclear magnetic resonance (NMR), and pyrolysis gas chromatography-mass spectrometry (Py-GC/MS). The results demonstrated that both DHS samples encountered the influences from marine source, indicating that algal and microbial-derived materials are the predominant precursors for the studied samples. The three fractions of DHS showed different properties. FAs presented more aromatic features, whereas HAs contained more aliphatic lipids and proteinaceous materials. The XAD-4 fractions were enriched in 13C and contained more carbohydrates but less aromatic compounds. The lower molecular weight and higher heteroatom content and number of carboxyl groups for the XAD-4 fractions may give them considerable geochemical significance for aspects of trace metal species, bioavailability of pollutants, mineral weathering and water acidification in marine environments.

  12. A Review on Dapsone Hypersensitivity Syndrome Among Chinese Patients with an Emphasis on Preventing Adverse Drug Reactions with Genetic Testing.

    PubMed

    Wang, Na; Parimi, Leela; Liu, Hong; Zhang, Furen

    2017-05-01

    AbstractDapsone is a bactericidal and bacteriostatic against Mycobacterium leprae , a causative agent of leprosy. Dapsone is also applied in a range of medical fields because of its anti-inflammatory and immunomodulatory effects. Dapsone hypersensitivity syndrome (DHS) is a rare yet serious adverse drug reaction (ADR) caused by dapsone involving multiple organs. We performed a systematic review of published articles describing dapsone-induced hypersensitivity syndrome, including all Chinese articles and the latest literature available in online databases published between October 2009 and October 2015. We determined the prevalence, clinical characteristics, and mortality rate of DHS. Importantly, we also summarized the recent advances in genetic testing allowing prediction of ADRs. In an initial systematic electronic search, we retrieved 191 articles. Subsequently, these articles were further filtered and ultimately 84 articles (60 Chinese case reports, 21 non-Chinese articles, and three epidemiological studies) were selected, which included 877 patients. The prevalence of DHS among Chinese patients was 1.5% with a fatality rate of 9.6%. Early withdrawal of dapsone and appropriate treatment reduced the fatality rate. Most importantly, genetic screening for the HLA-B*13:01 allele among high-risk populations showed a significant utility as a useful genetic marker to DHS. In conclusion, this review discusses the epidemiological and clinical characteristics of DHS among Chinese patients, which may help physicians to understand this syndrome.

  13. 77 FR 25185 - Agency Information Collection Activities: Submission for Review; Information Collection Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0013] Agency Information Collection... request for comment. SUMMARY: The Department of Homeland Security (DHS) invites the general public to... formation of online communities. All users are required to authenticate prior to entering the site. In...

  14. 78 FR 66036 - Agency Information Collection Activities: Submission for Review; Information Collection Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2013-0028] Agency Information Collection... request for comment. SUMMARY: The Department of Homeland Security (DHS) invites the general public to... formation of online communities. All users are required to authenticate prior to entering the site. In...

  15. 76 FR 34232 - Agency Information Collection Activities, Submission for Review; Information Collection Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0042] Agency Information Collection... request for comment. SUMMARY: The Department of Homeland Security (DHS) invites the general public to... formation of online communities. All users are required to authenticate prior to entering the site. In...

  16. 49 CFR 1549.3 - TSA inspection authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... transportation facilities; (vi) Review security plans; and (vii) Carry out such other duties, and exercise such... access media or identification media issued or approved by a certified cargo screening facility or other person, except that the TSA and DHS officials will have identification media issued by TSA or DHS. ...

  17. 6 CFR 11.7 - Private collection agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Private collection agencies. 11.7 Section 11.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS § 11.7 Private collection agencies. DHS will transfer delinquent DHS debts to the Treasury Department's Financial Management Service...

  18. 6 CFR 11.3 - Demand for payment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Demand for payment. 11.3 Section 11.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS § 11.3 Demand for payment. (a) Notice requirements. Generally, before DHS starts the collection actions described in this subpart, DHS...

  19. 6 CFR 11.9 - Collection in installments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Collection in installments. 11.9 Section 11.9 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS § 11.9 Collection in installments. DHS may accept payment of a DHS debt in regular installments, in accordance with the provisions...

  20. 6 CFR 11.9 - Collection in installments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Collection in installments. 11.9 Section 11.9 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS § 11.9 Collection in installments. DHS may accept payment of a DHS debt in regular installments, in accordance with the provisions...

  1. 75 FR 67383 - Extension of the Designation of Somalia for Temporary Protected Status

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services [CIS No. 2497-99; DHS... Status AGENCY: U.S. Citizenship and Immigration Services, Department of Homeland Security (DHS). ACTION... extension of their employment authorization documents (EADs) with U.S. Citizenship and Immigration Services...

  2. 77 FR 73669 - Response to Comments Received for the “The Menlo Report: Ethical Principles Guiding Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... Technology Research'' (``The Menlo Report'') for the Department of Homeland Security (DHS), Science and Technology, Cyber Security Division (CSD), Protected Repository for the Defense of Infrastructure Against Cyber Threats (PREDICT) Project AGENCY: Science and Technology Directorate, DHS. ACTION: Response...

  3. 75 FR 51468 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... research and development effort funded by DHS Science and Technology (S&T) Office of Small Business... Immigration Status Indicator Technology (US-VISIT) Program of DHS published this PIA to cover a new..., between the countries of Australia, Canada, New Zealand, United Kingdom, and the United States. The FCC...

  4. 75 FR 52542 - Extension of Agency Information Collection Activity Under OMB Review: Department of Homeland...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... Inquiry Program (DHS TRIP). The collection also involves a voluntary customer satisfaction survey to... customer satisfaction survey in accordance with the DHS Office of the Inspector General, Report on... completing customer satisfaction survey will take approximately 10 minutes per respondent. Number of...

  5. 77 FR 74685 - Chemical Facility Anti-Terrorism Standards (CFATS) Chemical-Terrorism Vulnerability Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... Programs Directorate (NPPD), Office of Infrastructure Protection (IP), Infrastructure Security Compliance... questions about this Information Collection Request should be forwarded to DHS/NPPD/IP/ISCD CFATS Program... to the DHS/NPPD/IP/ISCD CFATS Program Manager at the Department of Homeland Security, 245 Murray Lane...

  6. 77 FR 74677 - Chemical Facility Anti-Terrorism Standards (CFATS)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... Protection (IP), Infrastructure Security Compliance Division (ISCD) will submit the following Information... should be forwarded to DHS/NPPD/IP/ISCD CFATS Program Manager, 245 Murray Lane SW., Mail Stop 0610... should be appropriately marked and submitted by mail to the DHS/NPPD/IP/ISCD CFATS Program Manager, 245...

  7. 6 CFR 37.59 - DHS reviews of State compliance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 37.59 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S... compliance. State REAL ID programs will be subject to DHS review to determine whether the State meets the... review of the State's compliance at any time. In addition, the State must: (1) Provide any reasonable...

  8. 6 CFR 37.59 - DHS reviews of State compliance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 37.59 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S... compliance. State REAL ID programs will be subject to DHS review to determine whether the State meets the... review of the State's compliance at any time. In addition, the State must: (1) Provide any reasonable...

  9. 29 CFR 503.1 - Scope and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... 1184(c)(1) requires the Secretary of the Department of Homeland Security (DHS) to consult with... nonagricultural employment may not be approved by the Secretary of DHS unless the petitioner has applied for and received a temporary labor certification from the U.S. Secretary of Labor (Secretary). The temporary labor...

  10. 29 CFR 503.1 - Scope and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... 1184(c)(1) requires the Secretary of the Department of Homeland Security (DHS) to consult with... nonagricultural employment may not be approved by the Secretary of DHS unless the petitioner has applied for and received a temporary labor certification from the U.S. Secretary of Labor (Secretary). The temporary labor...

  11. 78 FR 8161 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2013-0005; OMB...: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency... comments to Docket Manager, Office of Chief Counsel, DHS/FEMA, 500 C Street SW., Room 835, Washington, DC...

  12. 48 CFR 3001.105-3 - Copies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

  13. 48 CFR 3001.105-3 - Copies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

  14. 48 CFR 3001.105-3 - Copies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

  15. 75 FR 39957 - Extension of the Initial Registration Period for Haitians Under the Temporary Protected Status...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services [CIS No. 2491-10; DHS... the Temporary Protected Status Program AGENCY: U.S. Citizenship and Immigration Services, DHS. ACTION..., Service Center Operations Directorate, U.S. Citizenship and Immigration Services, Department of Homeland...

  16. 75 FR 22609 - Agency Information Collection Activities; Proposals, Submissions, and Approvals: CIS Ombudsman...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... System AGENCY: Office of the Citizenship and Immigration Service Ombudsman, DHS. ACTION: 60-Day Notice... Department of Homeland Security, Office of the Citizenship and Immigration Service Ombudsman, will submit the... Request should be forwarded to Office of the Citizenship and Immigration Services Ombudsman, DHS, Attn...

  17. 78 FR 6827 - Public Availability of DHS Fiscal Year 2012 Service Contract Inventory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... Inventory AGENCY: Office of the Chief Procurement Officer, DHS. ACTION: Notice of availability. SUMMARY: In... availability of the FY 2012 Service Contract inventory. This inventory provides information on service contract... contracted resources are distributed throughout the agency. The inventory has been developed in accordance...

  18. 77 FR 4821 - Public Availability of DHS Fiscal Year 2011 Service Contract Inventory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Inventory AGENCY: Office of the Chief Procurement Officer, DHS. ACTION: Notice of availability. SUMMARY: In... availability of the FY 2011 Service Contract inventory. This inventory provides information on service contract... contracted resources are distributed throughout the agency. The inventory has been developed in accordance...

  19. 44 CFR 208.40 - Reimbursement of fringe benefit costs during Activation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... reimbursement sought from DHS. (c) DHS will not reimburse the Sponsoring Agency for fringe benefit costs for... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reimbursement of fringe... RESCUE RESPONSE SYSTEM Response Cooperative Agreements § 208.40 Reimbursement of fringe benefit costs...

  20. 75 FR 55290 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security/ALL-031...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ...; Department of Homeland Security/ALL-031 Information Sharing Environment Suspicious Activity Reporting... Environment Suspicious Activity Reporting Initiative System of Records'' and this proposed rulemaking. In this... establish a new DHS system of records titled, ``DHS/ALL-031 Information Sharing Environment (ISE) Suspicious...

  1. 76 FR 30952 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... the Web AGENCY: Privacy Office, DHS. ACTION: Notice of Publication of Privacy Impact Assessments (PIA... the Department. These assessments were approved and published on the Privacy Office's web site between January 8, 2011 and March 31, 2011. DATES: The PIAs will be available on the DHS Web site until July 26...

  2. 76 FR 78934 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... the Web AGENCY: Privacy Office, DHS. ACTION: Notice of Publication of Privacy Impact Assessments (PIA.... These assessments were approved and published on the Privacy Office's web site between September 1, 2011 and November 30, 2011. DATES: The PIAs will be available on the DHS Web site until February 21, 2012...

  3. 76 FR 19110 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... the Web AGENCY: Privacy Office, Department of Homeland Security (DHS). ACTION: Notice of Publication... the Privacy Office's Web site between May 3, 2010 and January 7, 2011. DATES: The Privacy Impact Assessments are available on the DHS Web site until June 6, 2011, after which they are obtained by contacting...

  4. 76 FR 37823 - Published Privacy Impact Assessments on the Web

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... the Web AGENCY: Privacy Office, DHS. ACTION: Notice of Publication of Privacy Impact Assessments (PIA... Department. These assessments were approved and published on the Privacy Office's Web site between March 31, 2011 and May 31, 2011. DATES: The PIAs will be available on the DHS Web site until August 29, 2011...

  5. Informing Food Protection Education: A Project to Define and Classify Resources for a Cross-Disciplinary Expert Community

    ERIC Educational Resources Information Center

    Schenck-Hamlin, Donna; Pierquet, Jennifer; McClellan, Chuck

    2011-01-01

    In the wake of the September 2001 attacks, the U.S. government founded the Department of Homeland Security (DHS) with responsibility to develop a National Infrastructure Protection Plan for securing critical infrastructures and key resources. DHS established interdisciplinary networks of academic expertise administered through Centers of…

  6. 76 FR 9034 - Privacy Act of 1974; Department of Homeland Security United States Citizenship and Immigration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... 1974; Department of Homeland Security United States Citizenship and Immigration Services--DHS/USCIS... of Homeland Security/ United States Citizenship and Immigration Services--SORN DHS/USCIS--013 E-Verify Self Check System of Records.'' The U.S. Citizenship and Immigration Services E-Verify Self Check...

  7. 77 FR 47767 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security U.S. Customs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... Protection, DHS/CBP--017 Analytical Framework for Intelligence (AFI) System of Records AGENCY: Privacy Office... Homeland Security/U.S. Customs and Border Protection, DHS/CBP--017 Analytical Framework for Intelligence... Analytical Framework for Intelligence (AFI) System of Records'' from one or more provisions of the Privacy...

  8. 78 FR 14103 - Request for Information (RFI) Regarding the Planned Biotechnology Development Module (BDM) as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... the United States Department of Agriculture (USDA), Agricultural Research Service (ARS) and Animal and...-ARS, USDA-APHIS, and DHS) to implement early product development initiatives in partnership with... will support customers from all three NBAF user groups (DHS S&T, ARS, and APHIS) as well as potential...

  9. 77 FR 70792 - Privacy Act of 1974; Retirement of Department of Homeland Security Transportation Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... from its inventory of record systems. TSA will rely upon DHS/ALL-017 General Legal Records (November 23, 2011, 76 FR 72428) to cover its legal activities. Eliminating the system of records notice DHS/TSA-009... Department of Homeland Security Transportation Security Administration System of Records AGENCY: Privacy...

  10. 76 FR 63206 - Supplemental Standards of Ethical Conduct for Employees of the Department of Homeland Security

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... [Docket No. DHS-2008-0168] RIN 1601-AA17; 3209-AA15 Supplemental Standards of Ethical Conduct for... of Government Ethics (OGE), is proposing supplemental standards of ethical conduct for DHS employees. The proposed regulations would supplement the OGE Standards of Ethical Conduct for Employees of the...

  11. 76 FR 39315 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security/ALL-030 Use of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... Terrorist Screening Database System of Records AGENCY: Privacy Office, DHS. ACTION: Notice of proposed... Use of the Terrorist Screening Database System of Records'' and this proposed rulemaking. In this... Use of the Terrorist Screening Database (TSDB) System of Records.'' DHS is maintaining a mirror copy...

  12. 77 FR 37912 - Committee Name: Homeland Security Academic Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ...Engagement@hq.dhs.gov or contact Lindsay Burton at 202-447-4686 as soon as possible. To facilitate public.... Email: AcademicEngagement@hq.dhs.gov . Include the docket number in the subject line of the message. Fax: 202-447-3713. Mail: Academic Engagement; MGMT/Office of Academic Engagement/Mailstop 0440; Department...

  13. 76 FR 75890 - Agency Information Collection Activities: Solicitation of Proposal Information for Award of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... burden. DHS S&T uses a secure Web site which the public can propose SBIR research topics and submit... submit SBIR research topics and submit response to DHS SBIR solicitations. Additionally, electronic web... Innovative Research (SBIR) and Small Business Technology Transfer (STTR) programs 15 U.S.C. 628. For...

  14. 78 FR 34014 - Proposed Flood Elevation Determinations for Bolivar County, Mississippi and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ..., identified by Docket No. FEMA-B- 1178, to Luis Rodriguez, Chief, Engineering Management Branch, Federal..., DC 20472, (202) 646-4064, or (email) fema.dhs.gov ">Luis[email protected] fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...

  15. Chemical Facility Preparedness: A Comprehensive Approach

    DTIC Science & Technology

    2006-09-01

    25 E. SWOT ANALYSIS & STRATEGIC ISSUE DEVELOPMENT ..............27 1. What can DHS do to Improve...be calculated and reviewed. Continuous benchmarking against best practices will be a necessity. E. SWOT ANALYSIS & STRATEGIC ISSUE DEVELOPMENT...In order to identify strategic issues for DHS, a Strength, Weakness, Opportunity and Threat ( SWOT ) analysis is necessary. Conducting this kind of

  16. 75 FR 56120 - Employment Authorization for Haitian F-1 Nonimmigrant Students Experiencing Severe Economic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... January 12, 2010 Earthquake in Haiti AGENCY: U.S. Immigration and Customs Enforcement; DHS. ACTION: Notice..., 2010 earthquake in Haiti. The Department of Homeland Security (DHS) is taking action to provide relief... severe economic hardship as a direct result of the January 12, 2010 earthquake in Haiti. This notice...

  17. 76 FR 53763 - Immigration Benefits Business Transformation, Increment I

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ...The Department of Homeland Security (DHS) is amending its regulations to enable U.S. Citizenship and Immigration Services (USCIS) to migrate from a paper file-based, non-integrated systems environment to an electronic customer-focused, centralized case management environment for benefit processing. This transformation process will allow USCIS to streamline benefit processing, eliminate the capture and processing of redundant data, and reduce the number of and automate its forms. This transformation process will be a phased multi-year initiative to restructure USCIS business processes and related information technology systems. DHS is removing references to form numbers, form titles, expired regulatory provisions, and descriptions of internal procedures, many of which will change during transformation. DHS is also finalizing interim rules that permitted submission of benefit requests with an electronic signature when such requests are submitted in an electronic format rather than on a paper form and that removed references to filing locations for immigration benefits. In addition, in this rule DHS is publishing the final rule for six other interim rules published during the past several years, most of which received no public comments.

  18. Optimal Operation System of the Integrated District Heating System with Multiple Regional Branches

    NASA Astrophysics Data System (ADS)

    Kim, Ui Sik; Park, Tae Chang; Kim, Lae-Hyun; Yeo, Yeong Koo

    This paper presents an optimal production and distribution management for structural and operational optimization of the integrated district heating system (DHS) with multiple regional branches. A DHS consists of energy suppliers and consumers, district heating pipelines network and heat storage facilities in the covered region. In the optimal management system, production of heat and electric power, regional heat demand, electric power bidding and sales, transport and storage of heat at each regional DHS are taken into account. The optimal management system is formulated as a mixed integer linear programming (MILP) where the objectives is to minimize the overall cost of the integrated DHS while satisfying the operation constraints of heat units and networks as well as fulfilling heating demands from consumers. Piecewise linear formulation of the production cost function and stairwise formulation of the start-up cost function are used to compute nonlinear cost function approximately. Evaluation of the total overall cost is based on weekly operations at each district heat branches. Numerical simulations show the increase of energy efficiency due to the introduction of the present optimal management system.

  19. Starting-Up the Irbene 16-m Fully Steerable Parabolic Antenna for Radioastronomic Observations

    NASA Astrophysics Data System (ADS)

    Bezrukov, V.; Berzinsh, A.; Gaigals, G.; Lesinsh, A.; Trokshs, J.

    2011-01-01

    The methodology proposed in the paper is based on the concept of Energy Efficiency Uninterrupted Development Cycle (EEUDC). The goal of the authors was to clarify how the district heating system (DHS) development is affected by the heat consumption. The primary emphasis was given to the hot water consumption, with its noticeable daily fluctuations as well as changes caused by those in the inhabitants' way of life. The methodology, which is in good agreement with the ideology of advanced management of DHS development, employs the ISO 14000 series of standards (widely applied in the sphere of environment management). In the work, experimental results are presented that have been obtained through monitoring the hot water consumption. The results evidence that this consumption and its usage indices correspond to the level achieved by Western (in particular, North-European) countries. This circumstance changes considerably the input data for calculation of DHS elements, making it possible to work out appropriate measures in order to improve the DHS efficiency through step-by-step replacement of the elements with high energy loss.

  20. iDHS-EL: identifying DNase I hypersensitive sites by fusing three different modes of pseudo nucleotide composition into an ensemble learning framework.

    PubMed

    Liu, Bin; Long, Ren; Chou, Kuo-Chen

    2016-08-15

    Regulatory DNA elements are associated with DNase I hypersensitive sites (DHSs). Accordingly, identification of DHSs will provide useful insights for in-depth investigation into the function of noncoding genomic regions. In this study, using the strategy of ensemble learning framework, we proposed a new predictor called iDHS-EL for identifying the location of DHS in human genome. It was formed by fusing three individual Random Forest (RF) classifiers into an ensemble predictor. The three RF operators were respectively based on the three special modes of the general pseudo nucleotide composition (PseKNC): (i) kmer, (ii) reverse complement kmer and (iii) pseudo dinucleotide composition. It has been demonstrated that the new predictor remarkably outperforms the relevant state-of-the-art methods in both accuracy and stability. For the convenience of most experimental scientists, a web server for iDHS-EL is established at http://bioinformatics.hitsz.edu.cn/iDHS-EL, which is the first web-server predictor ever established for identifying DHSs, and by which users can easily get their desired results without the need to go through the mathematical details. We anticipate that IDHS-EL: will become a very useful high throughput tool for genome analysis. bliu@gordonlifescience.org or bliu@insun.hit.edu.cn Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. Questions About Cervical and Breast Cancer Screening Knowledge, Practice, and Outcomes: A Review of Demographic and Health Surveys.

    PubMed

    Viens, Laura; Perin, Doug; Senkomago, Virginia; Neri, Antonio; Saraiya, Mona

    2017-05-01

    United Nation's Sustainable Development Goals and the World Health Organization's Global Monitoring Framework support a strong global commitment to reducing the high burden of cervical and breast cancers among low- and middle-income countries. Strategies include vaccination, screening, and early diagnosis. Population-based surveys, such as those conducted by the Demographic and Health Surveys (DHS) Program, can collect the information needed to guide cancer control efforts in a standardized comparable manner. We identified and evaluated the breadth of breast and cervical cancer screening information that was collected by the DHS from 1984 through 2015. Then, we determined if these surveys currently provide the specific and measurable data about both the quantity and quality of cancer screening needed to guide national efforts to reduce the overall effects of cervical and breast cancers. We searched the DHS website to identify surveys conducted between the start of the DHS Program in 1984 and November 2015 that included questions about breast and cervical cancer screening. The relevant questions were extracted from the questionnaire, translated into English, and grouped by themes. Of the 90 countries where DHS surveys have been implemented, cervical cancer screening questions were included in 22 countries (24.4%) and breast cancer screening questions in 18 countries (20.0%). The common themes identified were disease knowledge, screening knowledge, screening practice, and screening outcomes. Most countries with survey questionnaires available for review addressed at least one aspect of screening practice (88.9% of cervical and 87.5% of breast), although few countries queried knowledge and outcomes. Questions that assess varied aspects of breast and cervical cancer screening have been incorporated into relatively few DHS surveys. The themes identified could guide the design of a standard set of questions for use in future population-based surveys and enable evaluation beyond the existence of screening, which would include assessment of the quality and impact of cervical and breast cancer screening.

  2. Sliding hip screw versus sliding helical blade for intertrochanteric fractures: a propensity score-matched case control study.

    PubMed

    Fang, C; Lau, T W; Wong, T M; Lee, H L; Leung, F

    2015-03-01

    The spiral blade modification of the Dynamic Hip Screw (DHS) was designed for superior biomechanical fixation in the osteoporotic femoral head. Our objective was to compare clinical outcomes and in particular the incidence of loss of fixation. In a series of 197 consecutive patients over the age of 50 years treated with DHS-blades (blades) and 242 patients treated with conventional DHS (screw) for AO/OTA 31.A1 or A2 intertrochanteric fractures were identified from a prospectively compiled database in a level 1 trauma centre. Using propensity score matching, two groups comprising 177 matched patients were compiled and radiological and clinical outcomes compared. In each group there were 66 males and 111 females. Mean age was 83.6 (54 to 100) for the conventional DHS group and 83.8 (52 to 101) for the blade group. Loss of fixation occurred in two blades and 13 DHSs. None of the blades had observable migration while nine DHSs had gross migration within the femoral head before the fracture healed. There were two versus four implant cut-outs respectively and one side plate pull-out in the DHS group. There was no significant difference in mortality and eventual walking ability between the groups. Multiple logistic regression suggested that poor reduction (odds ratio (OR) 11.49, 95% confidence intervals (CI) 1.45 to 90.9, p = 0.021) and fixation by DHS (OR 15.85, 95%CI 2.50 to 100.3, p = 0.003) were independent predictors of loss of fixation. The spiral blade design may decrease the risk of implant migration in the femoral head but does not reduce the incidence of cut-out and reoperation. Reduction of the fracture is of paramount importance since poor reduction was an independent predictor for loss of fixation regardless of the implant being used. Cite this article: Bone Joint J 2015;97-B:398-404. ©2015 The British Editorial Society of Bone & Joint Surgery.

  3. [Stress test and clinical application of the minimal-invasive dynamic hip screw].

    PubMed

    Tong, Song-Lin; Chen, Jian-Lie; Lu, Wen-Jie; Pan, Zhi-Jun; Wang, Yi-Jin

    2008-05-01

    To recognize the effect of minimal-invasive dynamic hip screw (MIDHS) on the treatment of intertrochanteric fracture of the hip by biomechanical test and preliminary clinical application. Ten artifical made intertrochanteric fractures of femoral specimen from five cadavers were divided into two groups randomly. The fractures in first group were fixed by MIDHS and other group were fixed by dynamic hip (DHS). Biomechanical characteristics of two different devices were compared with the biomechanical character of load-straining, load-displacing, rigidity and strength of femur by statistic analysis. According to the Harris evaluation, healing effect of intertrochanteric fractures was evaluated clinically on the 15 cases. Straining changes of MIDHS were 14% and 11% less than that of DHS on the tensile side and the pressure side respectively; Sinking and horizontal displacement, were 19% and 22% less than that of DHS respectivly. But external and internal stress intensity,axial and bending rigidity were all higher than that of DHS, they were 12%, 11%, 19% and 37%. Maximal destroyed twisting moment (15%) and average twisting rigidity (15%) were both higher than that of DHS, but twisting angle was 18% less. Under the force, of 1 800 N, the open angle of the fracture on transverse section was 2.28 degrees,while the DHS's was 3.60 degrees . The data above were significant differences statistically (P < 0.01). The average Harris score of the 15 cases with intertrochanteric fractures treated by MIDHS was 91, excellent and good rate was 92.7%, without complications of internal fixation failure,postoperative infection and so on. The design of minimal-invasive dynamic hip screw is reasonable and effective against rotating, shearing and varus stress force of the fracture, and it provides possibility of implanting the internal fixation with minimal incision. So it is an ideal internal fixation device for the treatment of intertrochanteric fractures.

  4. Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters.

    PubMed

    Cremer, Marion; Schmid, Volker J; Kraus, Felix; Markaki, Yolanda; Hellmann, Ines; Maiser, Andreas; Leonhardt, Heinrich; John, Sam; Stamatoyannopoulos, John; Cremer, Thomas

    2017-08-07

    The association of active transcription regulatory elements (TREs) with DNAse I hypersensitivity (DHS[+]) and an 'open' local chromatin configuration has long been known. However, the 3D topography of TREs within the nuclear landscape of individual cells in relation to their active or inactive status has remained elusive. Here, we explored the 3D nuclear topography of active and inactive TREs in the context of a recently proposed model for a functionally defined nuclear architecture, where an active and an inactive nuclear compartment (ANC-INC) form two spatially co-aligned and functionally interacting networks. Using 3D structured illumination microscopy, we performed 3D FISH with differently labeled DNA probe sets targeting either sites with DHS[+], apparently active TREs, or DHS[-] sites harboring inactive TREs. Using an in-house image analysis tool, DNA targets were quantitatively mapped on chromatin compaction shaped 3D nuclear landscapes. Our analyses present evidence for a radial 3D organization of chromatin domain clusters (CDCs) with layers of increasing chromatin compaction from the periphery to the CDC core. Segments harboring active TREs are significantly enriched at the decondensed periphery of CDCs with loops penetrating into interchromatin compartment channels, constituting the ANC. In contrast, segments lacking active TREs (DHS[-]) are enriched toward the compacted interior of CDCs (INC). Our results add further evidence in support of the ANC-INC network model. The different 3D topographies of DHS[+] and DHS[-] sites suggest positional changes of TREs between the ANC and INC depending on their functional state, which might provide additional protection against an inappropriate activation. Our finding of a structural organization of CDCs based on radially arranged layers of different chromatin compaction levels indicates a complex higher-order chromatin organization beyond a dichotomic classification of chromatin into an 'open,' active and 'closed,' inactive state.

  5. Prevention of healthcare-associated infections: knowledge among dental students in seven Italian universities.

    PubMed

    Pasquarella, Cesira; Veronesi, Licia; Castiglia, Paolo; D'Alessandro, Daniela; Legnani, Pierpaolo; Minelli, Liliana; Montagna, Maria Teresa; Napoli, Christian; Righi, Elena; Strohmenger, Laura; Tesauro, Marina; Torre, Ida; Tanzi, Maria Luiza

    2015-01-01

    Lack of knowledge is the major reason for non-compliance with correct healthcare-associated infections (HAI) prevention procedures. The aim of this study was to evaluate knowledge of the Dental School (DSS) and Dental Hygiene (DHS) students with regard to the prevention of HAI, as basic knowledge for improving and harmonizing the educational content in the different Italian Universities. A cross-sectional study was carried out using an anonymous questionnaire that was completed by DSS (I, II, III, IV, and V year) in seven Universities and DHS (I, II, and III year) in three Universities. The questions dealt with three specific areas: healthcare-associated infections, standard precautions and hand hygiene. Factors associated with an unacceptable level of knowledge (score <17.5) were analyzed using a logistic regression model. A p value <0.05 was considered to be significant. Five hundred and four questionnaires were collected: 81.5% for DSS and 18.5% for DHS. Mean overall score (±DS) achieved by the total number of students was 18.2±2.93 on an overall perfect score of 25; 18.2±3.04 for DSS and 17.8±2.31 for DHS. Stratifying by area, the average score 2.7±1.07 (53%) for HAI, 10.3±1.61 (85.9%) for standard precautions, and 5.2±1.44 (64.8%) for hand hygiene was observed. A significantly different level of knowledge (p<0.001) between DSS and DHS was observed only for HAI (2.8±1.07 for DSS vs 2.1±0.96 for DHS). Significant differences among the academic years were found only for DSS concerning HAI and standard precautions. The logistic regression model showed that an age <23 years was a risk factor for lack of knowledge on HAI, but a protective factor for lack of knowledge about standard precautions and hand hygiene; attending DH degree course was associated with lack of knowledge on HAI. Although the overall score obtained both by DSS and DHS indicated an acceptable level of knowledge, lack of knowledge was highlighted, in particular, for hand hygiene. Therefore, it is necessary to implement and validate effective teaching models in undergraduate courses in order to provide the scientific basis and the theoretical and practical preparation for the prevention and control of HAI.

  6. Integrated Surveillance for the Next Generation Air Transportation System. Final Report of the Integrated Surveillance Study Team

    DTIC Science & Technology

    2008-10-31

    Navigation Services Working Group Jan de Regt FAA Tony Richardson JPDO Technical Support James Roberts DoD AFFSA Eric Rolfe JPDO Air Navigation...Kirsch DHS Drew Kuepper DoD eragency Architecture and Engineering Division Jay Merkle JPDO Int Paul Polski DHS ing GroupElizabeth Lynn ye JPDO Air

  7. 76 FR 67751 - Privacy Act of 1974; Department of Homeland Security, U.S. Customs and Border Protection, DHS/CBP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... System for Travel Authorization (ESTA) System of Records AGENCY: Privacy Office, DHS. ACTION: Notice of... Travel Authorization System of Records.'' This system collects and maintains a record of nonimmigrant aliens who want to travel to the United States under the Visa Waiver Program, and is used to determine...

  8. Reducing the Risk of Dangerous Chemicals Getting into the Wrong Hands

    ERIC Educational Resources Information Center

    Matthews, Nancy

    2008-01-01

    Under the Department of Homeland Security (DHS) Appropriations Act of 2007, DHS has the authority and funding to regulate security at facilities storing chemicals considered to be high-risk (P. L. 109-295, Section 550). This article discusses the Department's efforts to enhance the security of facilities that store chemicals that could be stolen…

  9. 77 FR 44642 - Privacy Act of 1974; Department of Homeland Security U.S. Customs and Border Protection-DHS/CBP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... 1974; Department of Homeland Security U.S. Customs and Border Protection-DHS/CBP-009 Electronic System for Travel Authorization (ESTA) System of Records AGENCY: Privacy Office, Department of Homeland Security. ACTION: Notice of Privacy Act system of records. SUMMARY: In accordance with the Privacy Act of...

  10. Doctorate Recipients from United States Universities. Summary Report 1980.

    ERIC Educational Resources Information Center

    Syverson, Peter D.

    A brief summary of data, in tables with some narrative, from the Survey of Earned Doctorates during fiscal year 1980 is presented. Both research and applied research doctorates with these degree designations are included: DAS, DArch, DA, DBA, JCD, DCJ, DCrim, EdD, DEng, DESc, ScDE, DEnv, DED, DFA, DF, DGS, DHS (Health and Safety), DHS (Hebrew…

  11. 76 FR 44451 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security/ALL-029 Civil...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... subsection (c)(3) (Accounting for Disclosures) because release of the accounting of disclosures could alert... DHS as well as the recipient agency. Disclosure of the accounting would, therefore, present a serious... external to DHS. The term ``routine use'' is defined, with respect to the disclosure of a record, as the...

  12. 76 FR 81517 - Submission for Review and Comment: “The Menlo Report: Ethical Principles Guiding Information and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ...'' (``Menlo Report'') for the Department of Homeland Security (DHS), Science and Technology, Cyber Security Division (CSD), Protected Repository for the Defense of Infrastructure Against Cyber Threats (PREDICT... be found at: http://www.cyber.st.dhs.gov/wp-content/uploads/2011/12/MenloPrinciplesCORE-20110915-r560...

  13. Homeland Security and Emergency Management Education: An Investigation into Workforce Needs

    ERIC Educational Resources Information Center

    Carlson, Cameron D.

    2017-01-01

    The U.S. Department of Homeland Security (DHS) was created in the wake of the September 11th 2001 terrorist events. DHS's formation, the largest reorganization of a governmental agency in over 50 years, brought a new emphasis on the protection of the nation, its citizens and its infrastructure to government emergency management policy. Previously,…

  14. Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation.

    PubMed

    Tai, Phillip W L; Wu, Hai; van Wijnen, André J; Stein, Gary S; Stein, Janet L; Lian, Jane B

    2017-01-01

    The ability to discover regulatory sequences that control bone-related genes during development has been greatly improved by massively parallel sequencing methodologies. To expand our understanding of cis-regulatory regions critical to the control of gene expression during osteoblastogenesis, we probed the presence of open chromatin states across the osteoblast genome using global DNase hypersensitivity (DHS) mapping. Our profiling of MC3T3 mouse pre-osteoblasts during differentiation has identified more than 224,000 unique DHS sites. Approximately 65% of these sites are dynamic during temporal stages of osteoblastogenesis, and a majority of them are located within non-promoter (intergenic and intronic) regions. Nearly half of all DHS sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 and/or the chromatin-related CTCF transcription factors. This finding reinforces the role of these regulatory proteins as essential components of the bone gene regulome. We observe a reduction in chromatin accessibility throughout the genome between pre-osteoblast and early osteoblasts. Our analysis also defined a class of differentially expressed genes that harbor DHS peaks centered within 1 kb downstream of transcriptional end sites (TES). These DHSs at the 3'-flanks of genes exhibit dynamic changes during differentiation that may impact regulation of the osteoblast genome. Taken together, the distribution of DHS regions within non-promoter locations harboring osteoblast and chromatin related transcription factor binding motifs, reflect novel cis-regulatory requirements to support temporal gene expression in differentiating osteoblasts.

  15. 20 CFR 655.665 - Notice to the Department of Homeland Security and the Employment and Training Administration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Training Administration. (a) The Administrator shall promptly notify the DHS and ETA of the entry of a... part, unless the Administrator notifies the DHS and ETA of the entry of a subsequent order lifting the... the cease and desist order, without having on file with ETA an attestation pursuant to § 655.520 of...

  16. 76 FR 41274 - Privacy Act of 1974; Department of Homeland Security/ALL-033 Reasonable Accommodations Records...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ..., telecommuting, or reassignment to a vacant position; and/or (3) acquisition or modification of equipment or... the control of an agency for which information is retrieved by the name of an individual or by some... possession or under the control of DHS by complying with DHS Privacy Act regulations, 6 CFR Part 5. The...

  17. 76 FR 67755 - Privacy Act of 1974; Department of Homeland Security U.S. Customs and Border Protection DHS/CBP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... 1974; Department of Homeland Security U.S. Customs and Border Protection DHS/CBP-003 Credit/Debit Card... Security/U.S Customs and Border Protection--003 Credit/Debit Card Data System of Records.'' This system... any credit and debit card transactions with it has with individuals. Additionally, the Department of...

  18. 76 FR 12269 - Minimum Standards for Driver's Licenses and Identification Cards Acceptable by Federal Agencies...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... compliant on or before May 11, 2011. Id. At the time DHS promulgated the REAL ID final rule, DHS recognized... time to ensure that the documents they issue meet the security requirements of the REAL ID Act. Without.... SUMMARY: Pursuant to the Department of Homeland Security's REAL ID regulations, States must be in full...

  19. Information Technology Strategic Plan 2009-2013

    DTIC Science & Technology

    2009-01-01

    and the absence of Enterprise funding models for shared services . Also, though progress has been made within the DHS IT community regarding...security access regulations for shared services ; and difficulties associated with 3 Office of the Chief Information Officer...infrastructure and shared services is the vision for the Infrastructure Transformation Program at DHS and is the means by which to reduce IT commodity

  20. Science and Technology for a Safer Nation

    DTIC Science & Technology

    2008-03-01

    facilities. “Harvesting Innovation” gathers detailed information about efforts supporting Laboratory-Directed Research and Development ( LDRD ...programs and shares this with DHS directors, division heads and program managers. Energy Department labs allocate some $400 million per year in LDRD ...correlate LDRD projects with DHS S&T strategic goals and ongoing programs as well as planned projects in all six S&T divisions. This minimizes

  1. A novel approach for toluene gas treatment using a downflow hanging sponge reactor.

    PubMed

    Yamaguchi, Tsuyoshi; Nakamura, Syoichiro; Hatamoto, Masashi; Tamura, Eisuke; Tanikawa, Daisuke; Kawakami, Shuji; Nakamura, Akinobu; Kato, Kaoru; Nagano, Akihiro; Yamaguchi, Takashi

    2018-05-01

    A novel gas-scrubbing bioreactor based on a downflow hanging sponge (DHS) reactor was developed as a new volatile organic compound (VOC) treatment system. In this study, the effects of varying the space velocity and gas/liquid ratio were investigated to assess the effectiveness of using toluene gas as a model VOC. Under optimal conditions, the toluene removal rate was greater than 80%, and the maximum elimination capacity was observed at approximately 13 g-C m -3  h -1 . The DHS reactor demonstrated slight pressure loss (20 Pa) and a high concentration of suspended solids (up to 30,000 mg/L-sponge). Cloning analysis of the 16S rRNA and functional genes of toluene degradation pathways (tmoA, todC, tbmD, xylA, and bssA) revealed that the clones belonging to the toluene-degrading bacterium Pseudomonas putida constituted the predominant species detected at the bottom of the DHS reactor. The toluene-degrading bacteria Pseudoxanthomonas spadix and Pseudomonas sp. were also detected by tmoA- and todC-targeted cloning analyses, respectively. These results demonstrate the potential for the industrial application of this novel DHS reactor for toluene gas treatment.

  2. Self-assembly in Dipolar Fluids

    NASA Astrophysics Data System (ADS)

    Ronti, Michela; Kantorovich, Sofia

    We are studying low temperature structural transitions in dipolar hard spheres (DHS), combining grand-canonical Monte Carlo simulations and direct analytical theoretical calculations. DHS is characterized by long-range anisotropic interactions: it consists of a point dipole at the center of a hard sphere. We are interested in low temperature and low density phase behaviour of DHS systems. From a theoretical point of view the process of self-assembly is not responsible for a phase transition; this belief was completely reverted by theoretical studies showing that the process of self-assembly is alone capable to induce phase transition. On the other hand in the last years it was proved that no sign of critical behaviour is observed, implementing efficient and tailored Monte Carlo algorithms. Moreover a theoretical approach based on Density Functional Theory was developed: a series of structural transitions were discovered providing evidence of a hierarchy in the structures on cooling. We are performing free-energy calculations in order to draw the phase diagram of DHS model. Comparing the numerical results with the theoretical ones shed light on the scenario of temperature induced structural transitions in magnetic nanocolloids. Etn-COLLDENSE (H2020-MCSA-ITN-2014, Grant No. 642774).

  3. A low-cost municipal sewage treatment system with a combination of UASB and the "fourth-generation" downflow hanging sponge reactors.

    PubMed

    Tandukar, M; Uemura, S; Machdar, I; Ohashi, A; Harada, H

    2005-01-01

    This paper presents an evaluation of the process performance of a pilot-scale "fourth generation" downflow hanging sponge (DHS) post-treatment system combined with a UASB pretreatment unit treating municipal wastewater. After the successful operation of the second- and third-generation DHS reactors, the fourth-generation DHS reactor was developed to overcome a few shortcomings of its predecessors. This reactor was designed to further enhance the treatment efficiency and simplify the construction process in real scale, especially for the application in developing countries. Configuration of the reactor was modified to enhance the dissolution of air into the wastewater and to avert the possible clogging of the reactor especially during sudden washout from the UASB reactor. The whole system was operated at a total hydraulic retention time (HRT) of 8 h (UASB: 6 h and DHS: 2 h) for a period of over 600 days. The combined system was able to remove 96% of unfiltered BOD with only 9 mg/L remaining in the final effluent. Likewise, F. coli were removed by 3.45 log with the final count of 10(3) to 10(4) MPN/100 ml. Nutrient removal by the system was also satisfactory.

  4. FOILFEST :community enabled security.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moore, Judy Hennessey; Johnson, Curtis Martin; Whitley, John B.

    2005-09-01

    The Advanced Concepts Group of Sandia National Laboratories hosted a workshop, ''FOILFest: Community Enabled Security'', on July 18-21, 2005, in Albuquerque, NM. This was a far-reaching look into the future of physical protection consisting of a series of structured brainstorming sessions focused on preventing and foiling attacks on public places and soft targets such as airports, shopping malls, hotels, and public events. These facilities are difficult to protect using traditional security devices since they could easily be pushed out of business through the addition of arduous and expensive security measures. The idea behind this Fest was to explore how themore » public, which is vital to the function of these institutions, can be leveraged as part of a physical protection system. The workshop considered procedures, space design, and approaches for building community through technology. The workshop explored ways to make the ''good guys'' in public places feel safe and be vigilant while making potential perpetrators of harm feel exposed and convinced that they will not succeed. Participants in the Fest included operators of public places, social scientists, technology experts, representatives of government agencies including DHS and the intelligence community, writers and media experts. Many innovative ideas were explored during the fest with most of the time spent on airports, including consideration of the local airport, the Albuquerque Sunport. Some provocative ideas included: (1) sniffers installed in passage areas like revolving door, escalators, (2) a ''jumbotron'' showing current camera shots in the public space, (3) transparent portal screeners allowing viewing of the screening, (4) a layered open/funnel/open/funnel design where open spaces are used to encourage a sense of ''communitas'' and take advantage of citizen ''sensing'' and funnels are technological tunnels of sensors (the tunnels of truth), (5) curved benches with blast proof walls or backs, (6) making it easy for the public to report, even if not sure/''non-event'' (e.g. ''I'm uncomfortable'') and processing those reports in aggregate not individually, (7) transforming the resident working population into a part-time undercover security/sensor force through more innovative training and (8) adding ambassadors/security that engage in unexpected conversation with the public. The group recommended that we take actions to pursue the following ideas next: (a) A concept for a mobile sensor transport (JMP); (b) Conduct a follow-on workshop; (c) Conduct social experiments/activities to see how people would react to the concepts related to community and security; (d) Explore further aesthetically pleasing, blast-resistance seating areas; and (e) The Art of Freedom (an educational, multi-media campaign).« less

  5. Satellite Surveillance: Domestic Issues

    DTIC Science & Technology

    2010-02-01

    overflights or of covert agents . Satellite imagery undergirded U.S. strategic planning for a quarter century and a series of arms control agreements...as the executive agent of what it termed a new Domestic Applications Office (DAO). This recommendation was based on the premise that “DHS was...departments for creating and maintaining geospatial information to support homeland security. In May 2007, the DNI designated DHS as the executive agent and

  6. Project Amistad (Friendship), a Joint Venture between DHS and Family Outreach. Final Report: Innovations in Protective Services.

    ERIC Educational Resources Information Center

    Dennis-Small, Lucretia

    Conducted by the Texas Department of Human Services (DHS), Project Amistad (Friendship) originally set out to recruit and train Black and Hispanic volunteers to conduct lay therapy sessions with Black and Hispanic families in which abuse and neglect of children had occurred. Start-up was significantly delayed due to personnel changes; as a result,…

  7. An Analysis of IT Governance Practices in the Federal Government: Protecting U.S. Critical Infrastructure from Cyber Terrorist Attacks

    ERIC Educational Resources Information Center

    Johnson, R. LeWayne

    2012-01-01

    Much of the governing process in the United States (U.S.) today depends on a reliable and well protected public information technology (IT) infrastructure. The Department of Homeland Security (DHS) is tasked with the responsibility of protecting the country's IT infrastructure. Critics contend that the DHS has failed to address planning and…

  8. Sources of global warming of the upper ocean on decadal period scales

    USGS Publications Warehouse

    White, Warren B.; Dettinger, M.D.; Cayan, D.R.

    2003-01-01

    Recent studies find global climate variability in the upper ocean and lower atmosphere during the twentieth century dominated by quasi-biennial, interannual, quasi-decadal and interdecadal signals. The quasi-decadal signal in upper ocean temperature undergoes global warming/cooling of ???0.1??C, similar to that occuring with the interannual signal (i.e., El Nin??o-Southern Oscillation), both signals dominated by global warming/cooling in the tropics. From the National Centers for Environmental Prediction troposphere reanalysis and Scripps Institution of Oceanography upper ocean temperature reanalysis we examine the quasi-decadal global tropical diabetic heat storage (DHS) budget from 1975 to 2000. We find the anomalous DHS warming tendency of 0.3-0.9 W m-2 driven principally by a downward global tropical latent-plus-sensible heat flux anomaly into the ocean, overwhelming the tendency by weaker upward shortwave-minus-longwave heat flux anomaly to drive an anomalous DHS cooling tendency. During the peak quasi-decadal warming the estimated dissipation of DHS anomaly of 0.2-0.5 W m-2 into the deep ocean and a similar loss to the overlying atmosphere through air-sea heat flux anomaly are balanced by a decrease in the net poleward Ekman heat advection out of the tropics of 0.4-0.7 W m-2. This scenario is nearly the opposite of that accounting for global tropical warming during the El Nin??o. These diagnostics confirm that even though the global quasi-decadal signal is phase-locked to the 11-year signal in the Sun's surface radiative forcing of ???0.1 W m-2, the anomalous global tropical DHS tendency cannot be driven by it directly.

  9. Silibinin and its 2,3-Dehydro-derivative Inhibit Basal Cell Carcinoma Growth via Suppression of Mitogenic Signaling and Transcription Factors Activation

    PubMed Central

    Tilley, Cynthia; Deep, Gagan; Agarwal, Chapla; Wempe, Michael F; Biedermann, David; Valentová, Kateřina; Kren, Vladimir; Agarwal, Rajesh

    2014-01-01

    Basal cell carcinoma (BCC) is the most common cancer worldwide, and its current treatment options are insufficient and toxic. Surprisingly, unlike several other malignancies, chemopreventive efforts against BCC are almost lacking. Silibinin, a natural agent from milk thistle seeds, has shown strong efficacy against several cancers including ultraviolet radiation-induced skin (squamous) cancer; however, its potential activity against BCC is not yet examined. Herein, for the first time, we report the efficacy of silibinin and its oxidation product 2,3-dehydrosilibinin (DHS) against BCC both in vitro and in vivo using ASZ (p53 mutated) and BSZ (p53 deleted) cell lines derived from murine BCC tumors. Both silibinin and DHS significantly inhibited cell growth and clonogenicity while inducing apoptosis in a dose- and time-dependent manner, with DHS showing higher activity at lower concentrations. Both agents also inhibited the mitogenic signaling by reducing EGFR, ERK1/2, Akt, and STAT3 phosphorylation and suppressed the activation of transcription factors NF-κB and AP-1. More importantly, in an ectopic allograft model, oral administration of silibinin and DHS (200 mg/kg body weight) strongly inhibited the ASZ tumor growth by 44 and 71% (p<0.05), respectively, and decreased the expression of proliferation biomarkers (PCNA and cyclin D1) as well as NF-κB p50 and c-Fos in the tumor tissues. Taken together, these results provide the first evidence for the efficacy and usefulness of silibinin and its derivative DHS against BCC, and suggest the need for additional studies with these agents in pre-clinical and clinical BCC chemoprevention and therapy models. PMID:25492239

  10. Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.

    PubMed

    Tilley, Cynthia; Deep, Gagan; Agarwal, Chapla; Wempe, Michael F; Biedermann, David; Valentová, Kateřina; Kren, Vladimir; Agarwal, Rajesh

    2016-01-01

    Basal cell carcinoma (BCC) is the most common cancer worldwide, and its current treatment options are insufficient and toxic. Surprisingly, unlike several other malignancies, chemopreventive efforts against BCC are almost lacking. Silibinin, a natural agent from milk thistle seeds, has shown strong efficacy against several cancers including ultraviolet radiation-induced skin (squamous) cancer; however, its potential activity against BCC is not yet examined. Herein, for the first time, we report the efficacy of silibinin and its oxidation product 2,3-dehydrosilibinin (DHS) against BCC both in vitro and in vivo using ASZ (p53 mutated) and BSZ (p53 deleted) cell lines derived from murine BCC tumors. Both silibinin and DHS significantly inhibited cell growth and clonogenicity while inducing apoptosis in a dose- and time-dependent manner, with DHS showing higher activity at lower concentrations. Both agents also inhibited the mitogenic signaling by reducing EGFR, ERK1/2, Akt, and STAT3 phosphorylation and suppressed the activation of transcription factors NF-κB and AP-1. More importantly, in an ectopic allograft model, oral administration of silibinin and DHS (200 mg/kg body weight) strongly inhibited the ASZ tumor growth by 44% and 71% (P < 0.05), respectively, and decreased the expression of proliferation biomarkers (PCNA and cyclin D1) as well as NF-κB p50 and c-Fos in the tumor tissues. Taken together, these results provide the first evidence for the efficacy and usefulness of silibinin and its derivative DHS against BCC, and suggest the need for additional studies with these agents in pre-clinical and clinical BCC chemoprevention and therapy models. © 2014 Wiley Periodicals, Inc.

  11. Comparison of Practices, Knowledge, Confidence, and Attitude toward Oral Cancer among Oral Health Professionals between Japan and Australia.

    PubMed

    Haresaku, Satoru; Makino, Michiko; Sugiyama, Seiichi; Naito, Toru; Mariño, Rodrigo Jose

    2018-04-01

    The purpose of this study was to investigate the practices, knowledge, confidence, and attitude toward oral cancer among Japanese oral health professionals (J-OHPs) and to identify Japanese-specific problems in oral cancer practices by comparing them between Japan and Australia. A questionnaire survey regarding oral cancer practices among Australian oral health professionals (Au-OHPs) was conducted in Australia in 2014-2015. The questionnaire was translated into Japanese, and a Web-based questionnaire survey was conducted among 131 Japanese dentists (J-Dentists) and 131 dental hygienists (J-DHs) in 2016. To compare the J-OHPs' findings with the Au-OHPs', the data of Australian dentists (Au-dentists) and Australian dental hygienists (Au-DHs) were extracted from the Australian survey. Those findings were then compared via a statistical analysis. Eighty-two J-Dentists, 55 J-DHs, 214 Au-Dentists, and 45 Au-DHs participated in this study. Only 34.1 % of J-Dentists and 36.4 % of J-DHs performed oral cancer screenings on their patients; J-OHPs were significantly less likely to perform them than Au-OHPs. The level of knowledge and confidence regarding oral cancer among JOHPs were significantly lower than among Au-OHPs. About 90 % of J-OHPs felt that they needed additional training in oral cancer practices. Less than 40 % of J-OHPs performed oral cancer screenings in their patients. The low level of knowledge and confidence regarding oral cancer among JOHPs may contribute to their low performance of oral cancer practices. Therefore, further education and training programs for oral cancer practices should be provided to Japanese OHPs for the prevention and early detection of oral cancer.

  12. Eukaryotic Community Shift in Response to Organic Loading Rate of an Aerobic Trickling Filter (Down-Flow Hanging Sponge Reactor) Treating Domestic Sewage.

    PubMed

    Miyaoka, Yuma; Hatamoto, Masashi; Yamaguchi, Takashi; Syutsubo, Kazuaki

    2017-05-01

    In this study, changes in eukaryotic community structure and water quality were investigated in an aerobic trickling filter (down-flow hanging sponge, DHS) treating domestic sewage under different organic loading rates (OLRs). The OLR clearly influenced both sponge pore water quality and relative flagellates and ciliates (free-swimming, carnivorous, crawling, and stalked protozoa) abundances in the retained sludge. Immediately after the OLR was increased from 1.05 to 1.97 kg chemical oxygen demand (COD) m -3  day -1 , COD and NH 4 + -N treatment efficiencies both deteriorated, and relative flagellates and ciliates abundances then increased from 2-8 % to 51-65 % total cells in the middle-bottom part of the DHS reactor. In a continuous operation at a stable OLR (2.01 kg COD m -3  day -1 ), effluent water quality improved, and relative flagellates and ciliates abundances decreased to 15-46 % total cells in the middle-bottom part of the DHS reactor. This result may indicate that flagellates and ciliates preferentially graze on dispersed bacteria, thus, stabilizing effluent water quality. Additionally, to investigate eukaryotic community structure, clone libraries based on the 18S ribosomal ribonucleic acid (rRNA) gene of the retained sludge were constructed. The predominant group was Nucletmycea phylotypes, representing approximately 29-56 % total clones. Furthermore, a large proportion of the clones had <97 % sequence identity in the NCBI database. This result indicates that phylogenetically unknown eukaryotes were present in the DHS reactor. These results provide insights into eukaryotic community shift in the DHS reactor treating domestic sewage.

  13. The prognostic value of tip-to-apex distance (TAD index) in intertrochanteric fractures fixed by dynamic hip screw.

    PubMed

    Sedighi, Ali; Sales, Jafar Ganjpour; Alavi, Sahar

    2012-11-02

    Intertrochanteric fractures (ITFs) are the most common type of fractures requiring surgical intervention. They also have the highest surgical mortality among orthopedic operations. Among the many different techniques used for fixation of this type of fracture, use of the Dynamic Hip Screw (DHS) has gained wide acceptance. This current study was designed to assess positive predictive value of tip-to-apex distance (TAD) index in the prognosis of patients treated with DHS. The study was designed according to a descriptive-analytic protocol, made up of 100 cases of ITFs caused by falling, treated in the Shohada Orthopedic Center, Tabriz, Iran. All patients underwent lateral and antero-posterior hip X-ray to measure TAD index. The cohort was followed for three months after DHS placement. Of a total of 100 cases (53 male, 47 female) with a mean age of 76.7 years (range 29-100 years), 43% had grade 4, 29% grade 3, 21% grade 5, 5% grade 2 and 2% grade 6 osteoporosis. The screw position was postero-inferior in 57%, central in 40% and superior in 3% of patients. Minimum and maximum TAD index were 20 and 28 mm, respectively. Mean TAD was 23.5 mm. There were no post-operative complications in 84% of cases. Screw failure was the most common complication in the remaining 16% of patients. The study shows a statistically significant correlation between TAD index and cut-off rate in patients with intertrochanteric fractures of femoral bone treated by DHS. This validates the use of TAD index in determining the prognosis of patients treated by DHS.

  14. The Department of Homeland Security’s Role in Protecting the National Economy

    DTIC Science & Technology

    2017-09-01

    national influence, power, and security. However, new characteristics of the modern trade environment have the potential to undermine U.S. economic ...prosperity. The Department of Homeland Security (DHS) claims that homeland security is inseparable from economic security and, as such, that the...department has a role to play in supporting national economic security goals. However, DHS has yet to fully reconcile the tension between its trade

  15. Report of the DHS Small Vessel Security Institute

    DTIC Science & Technology

    2007-10-19

    sector interests are integral parts of the nation’s strategy of “layered security” in the face of hostile intent. Since the earliest days of the ...and secure as possible while simultaneously protecting our citizen’s enjoyment of their maritime heritage. Today, the Department of Homeland Security...of the discussions (in a neutral, non- attribution format) to serve as the starting point of an ongoing, unprecedented partnership by DHS and the

  16. Critical Infrastructure: The National Asset Database

    DTIC Science & Technology

    2007-07-16

    Infrastructure: The National Asset Database 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...upon which federal resources, including infrastructure protection grants , are allocated. According to DHS, both of those assumptions are wrong. DHS...assets that it has determined are critical to the nation. Also, while the National Asset Database has been used to support federal grant -making

  17. Achieving Homeland Security in a Time of Diminishing Resources

    DTIC Science & Technology

    2012-06-08

    and merged over 22 federal agencies and programs under the DHS umbrella. The overall mission of DHS is to enact “ a concerted national effort to ensure... A concerted national effort to prevent terrorist attacks within the United States; reduce America’s vulnerability to terrorism, major disasters...activity or effort performed to protect a nation against attack or other threats National Security. Requirement to maintain the survival of the state

  18. Risk assessment methodology applied to counter IED research & development portfolio prioritization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shevitz, Daniel W; O' Brien, David A; Zerkle, David K

    2009-01-01

    In an effort to protect the United States from the ever increasing threat of domestic terrorism, the Department of Homeland Security, Science and Technology Directorate (DHS S&T), has significantly increased research activities to counter the terrorist use of explosives. More over, DHS S&T has established a robust Counter-Improvised Explosive Device (C-IED) Program to Deter, Predict, Detect, Defeat, and Mitigate this imminent threat to the Homeland. The DHS S&T portfolio is complicated and changing. In order to provide the ''best answer'' for the available resources, DHS S&T would like some ''risk based'' process for making funding decisions. There is a definitemore » need for a methodology to compare very different types of technologies on a common basis. A methodology was developed that allows users to evaluate a new ''quad chart'' and rank it, compared to all other quad charts across S&T divisions. It couples a logic model with an evidential reasoning model using an Excel spreadsheet containing weights of the subjective merits of different technologies. The methodology produces an Excel spreadsheet containing the aggregate rankings of the different technologies. It uses Extensible Logic Modeling (ELM) for logic models combined with LANL software called INFTree for evidential reasoning.« less

  19. A Role for Science in Responding to Health Crises

    PubMed Central

    Brothers, Reginald; Murata, Christina E.

    2016-01-01

    The Department of Homeland Security's (DHS) Science and Technology (S&T) Directorate plays a role in public health that extends beyond biodefense. These responsibilities were exercised as part of the 2014-16 Ebola outbreak, leading to productive and beneficial contributions to the international public health response and improved operations in the United States. However, we and others have identified numerous areas for improvement. Based on our successes and lessons learned, we propose a number of ways that DHS, the interagency, and academia can act now to ensure improved responses to future public health crises. These include pre-developing scientific capabilities to respond agnostically to threats, and disease-specific master question lists to organize and inform initial efforts. We are generating DHS-specific playbooks and tools for anticipating future needs and capturing requests from DHS components and our national and international partners, where efforts will also be used to refine and exercise communication and information-sharing practices. These experiences and improvement efforts have encouraged discussions on the role of science in developing government policy, specifically responding to public health crises. We propose specific considerations for both scientists and government decision makers to ensure that the best available science is incorporated into policy and operational decisions to facilitate highly effective responses to future health crises. PMID:27482881

  20. The NOAO NEWFIRM Data Handling System

    NASA Astrophysics Data System (ADS)

    Zárate, N.; Fitzpatrick, M.

    2008-08-01

    The NOAO Extremely Wide-Field IR Mosaic (NEWFIRM) is a new 1-2.4 micron IR camera that is now being commissioned for the 4m Mayall telescope at Kitt Peak. The focal plane consists of a 2x2 mosaic of 2048x2048 arrays offerring a field-of-view of 27.6' on a side. The use of dual MONSOON array controllers permits very fast readout, a scripting interface allows for highly efficient observing modes. We describe the Data Handling System (DHS) for the NEWFIRM camera which is designed to meet the performance requirements of the instrument as well as the observing environment in which in operates. It is responsible for receiving the data stream from the detector and instrument software, rectifying the image geometry, presenting a real-time display of the image to the user, final assembly of a science-grade image with complete headers, as well as triggering automated pipeline and archival functions. The DHS uses an event-based messaging system to control multiple processes on a distributed network of machines. The asynchronous nature of this processing means the DHS operates independently from the camera readout and the design of the system is inherently scalable to larger focal planes that use a greater number of array controllers. Current status and future plans for the DHS are also discussed.

  1. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydro-sphingosine 1-phosphate in human neural progenitor cells

    USDA-ARS?s Scientific Manuscript database

    In-vivo and in-vitro studies suggest a crucial role for Sphingosine 1-phosphate (S1P) and its receptors in the development of the nervous system. Dihydrosphingosine 1-phosphate (dhS1P), a reduced form of S1P, is an active ligand at S1P receptors, but the pharmacology and physiology of dhS1P has not...

  2. Student and Exchange Visitor Program: DHS Needs to Assess Risks and Strengthen Oversight Functions. Report to Congressional Requesters. GAO-12-572

    ERIC Educational Resources Information Center

    Gambler, Rebecca

    2012-01-01

    As of January 2012, more than 850,000 active foreign students were in the United States enrolled at over 10,000 U.S. schools. ICE, within DHS, is responsible for managing SEVP and certifying schools to accept foreign students. GAO was asked to review ICE's fraud prevention and detection procedures for SEVP. This report examines the extent to which…

  3. Network Interdependency Modeling for Risk Assessment on Built Infrastructure Systems

    DTIC Science & Technology

    2013-10-01

    does begin to address infrastructure decay as a source of risk comes from the Department of Homeland Security (DHS). In 2009, the DHS Science and...network of connected edges and nodes. The National Research Council (2005) reported that the study of networks as a science and applications of...principles from this science are still in its early stages. As modern infrastructures have become more interlinked, knowledge of an infrastructure’s network

  4. The Evaluation of Carpet Steam/Heat Cleaners as Biological Sampling Device

    DTIC Science & Technology

    2011-12-08

    Vacuum Cleaner Evaluation as sampling Device Test Plan DHS Page 16 of 16 Fumigants , and Issues Related to Laboratory-scale Studies. Appl. Environ...ECBC Wet/dry Vacuum Cleaner Evaluation as sampling Device Test Plan DHS Page 1 of 16 Test Plan for The Evaluation of Carpet Steam...b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 ECBC Wet/dry Vacuum Cleaner

  5. The 'dark matter' in the plant genomes: non-coding and unannotated DNA sequences associated with open chromatin.

    PubMed

    Jiang, Jiming

    2015-04-01

    Sequencing of complete plant genomes has become increasingly more routine since the advent of the next-generation sequencing technology. Identification and annotation of large amounts of noncoding but functional DNA sequences, including cis-regulatory DNA elements (CREs), have become a new frontier in plant genome research. Genomic regions containing active CREs bound to regulatory proteins are hypersensitive to DNase I digestion and are called DNase I hypersensitive sites (DHSs). Several recent DHS studies in plants illustrate that DHS datasets produced by DNase I digestion followed by next-generation sequencing (DNase-seq) are highly valuable for the identification and characterization of CREs associated with plant development and responses to environmental cues. DHS-based genomic profiling has opened a door to identify and annotate the 'dark matter' in sequenced plant genomes. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. High-performance data processing using distributed computing on the SOLIS project

    NASA Astrophysics Data System (ADS)

    Wampler, Stephen

    2002-12-01

    The SOLIS solar telescope collects data at a high rate, resulting in 500 GB of raw data each day. The SOLIS Data Handling System (DHS) has been designed to quickly process this data down to 156 GB of reduced data. The DHS design uses pools of distributed reduction processes that are allocated to different observations as needed. A farm of 10 dual-cpu Linux boxes contains the pools of reduction processes. Control is through CORBA and data is stored on a fibre channel storage area network (SAN). Three other Linux boxes are responsible for pulling data from the instruments using SAN-based ringbuffers. Control applications are Java-based while the reduction processes are written in C++. This paper presents the overall design of the SOLIS DHS and provides details on the approach used to control the pooled reduction processes. The various strategies used to manage the high data rates are also covered.

  7. Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis).

    PubMed

    Sterenczak, Katharina A; Kleinschmidt, Sven; Wefstaedt, Patrick; Eberle, Nina; Hewicker-Trautwein, Marion; Bullerdiek, Jörn; Nolte, Ingo; Murua Escobar, Hugo

    2011-05-01

    Disorders of histiocytic origin affecting humans and dogs share various similarities. Canine disseminated histiocytic sarcoma (DHS) (formerly known as malignant histiocytosis) is an aggressive neoplasm of interstitial dendritic cells (DCs). The receptor for glycation end products (RAGE) and the high mobility group box1 protein (HMGB1) have been shown to be required for the maturation and migration of DCs. Thus, deregulation of the expression of these genes could have a major effect on the progression of histiocytic disorders. Neoplastic canine DHS samples and non-neoplastic control samples were analysed immunohistochemically and via real-time PCR. Significant down-regulation of RAGE in the lung tumour samples and down-regulation of HMGB1 in the lung, lymph node and spleen tumour samples were detected compared to their non-neoplastic counterparts. RAGE and HMGB1 expression down-regulation in canine DHS points to a role in the progression of histiocytic disorders.

  8. Repeated Evolution of the Pyrrolizidine Alkaloid–Mediated Defense System in Separate Angiosperm LineagesW⃞

    PubMed Central

    Reimann, Andreas; Nurhayati, Niknik; Backenköhler, Anita; Ober, Dietrich

    2004-01-01

    Species of several unrelated families within the angiosperms are able to constitutively produce pyrrolizidine alkaloids as a defense against herbivores. In pyrrolizidine alkaloid (PA) biosynthesis, homospermidine synthase (HSS) catalyzes the first specific step. HSS was recruited during angiosperm evolution from deoxyhypusine synthase (DHS), an enzyme involved in the posttranslational activation of eukaryotic initiation factor 5A. Phylogenetic analysis of 23 cDNA sequences coding for HSS and DHS of various angiosperm species revealed at least four independent recruitments of HSS from DHS: one within the Boraginaceae, one within the monocots, and two within the Asteraceae family. Furthermore, sequence analyses indicated elevated substitution rates within HSS-coding sequences after each gene duplication, with an increased level of nonsynonymous mutations. However, the contradiction between the polyphyletic origin of the first enzyme in PA biosynthesis and the structural identity of the final biosynthetic PA products needs clarification. PMID:15466410

  9. Department of Homeland Security Summer Internship

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Olsen, Erika J.

    2010-07-30

    My time at Lawrence Livermore National Laboratory (LLNL) has been one of the most rewarding and exciting experiences of my life. When I first applied for a Department of Homeland Security (DHS) internship I was concerned that my major in Mass Communications and Emergency Management would not be suited for the hard science environment. Thankfully DHS and my mentor, Brooke Buddemeier, demonstrated that the skills and knowledge I possess are critical for the successful integration of good science into Homeland Security and emergency response, and allowed me the opportunity to work on an exciting project. This paper intends to givemore » an overview of my experiences while at LLNL, explain the project I have been a part of, explain my specific role within that project, discuss my achievements, explain how my internship has changed where I plan to take my career path, and, finally, discuss how I believe DHS can enhance their future internship programs.« less

  10. Effect of hydraulic retention time on the performance of down-flow hanging sponge system treating grey wastewater.

    PubMed

    Tawfik, Ahmed; Wahab, Rifaat Abdel; Al-Asmer, Azza; Matary, Fatma

    2011-08-01

    Grey wastewater (GW) treatment via down-flow hanging sponge (DHS) system was the subject of the study. The reactor was operated at different hydraulic retention times (HRTs) of 11.7, 5.8 and 2.9 h, corresponding to organic loading rates (OLRs) of 1.9, 3.6 and 6.8 kgCOD/m3 day, respectively. The results obtained revealed that decreasing the HRT from 11.7 to 2.9 h negatively affected on the performance of the DHS system. COD(total), COD(soluble), COD(particulate) and detergent removal efficiency were reduced from 96 ± 2.4 to 90 ± 2.3%, from 83 ± 10 to 69 ± 8%, from 98 ± 2 to 94 ± 3% and from 96 ± 12 to 88 ± 6.9%, respectively. However, the removal efficiency of the distinguished COD fractions and detergent remained unaffected when decreasing the HRT from 11.7 to 5.8 h. The DHS system provided a removal efficiency of 95 ± 1% for COD(total), 79 ± 8% for COD(soluble), 98 ± 2 for COD(particulate) and 94.7% for detergent at an HRT of 5.8 h. Based on these results, it is recommended to operate such a system at an HRT of 5.8 h and OLR not exceeding 3.6 kgCOD/m3 day for producing an effluent quality complying for reuse in unrestricted irrigation purposes. The removal of TKj-N and nitrification efficiency in the DHS system was significantly affected by increasing the OLR from 1.9 to 3.6 kgCOD/m3 day and from 3.6 to 6.8 kgCOD/m3 day. At an OLR of 1.9 kgCOD/m3 day, the DHS system removed 80 ± 12% of TKj-N and 91 ± 22% of ammonia which is significantly higher than that at an OLR of 3.6 (58.5 ± 13%) and 6.8 kgCOD/m3 day (26.8 ± 16%). Similar results were recorded for the removal of total coliform (TC), viz., the efficiencies dropped for TC from 99.8 ± 0.2 to 99.4 ± 0.8% and from 99.4 ± 0.8 to 90.0 ± 7.6%, respectively. DHS profile results showed that the major part of COD was removed in the upper portion of the system while the nitrification process was taken place in the lower part of the DHS system at OLR of 1.9 kgCOD/m3 day and HRT of 11.7 h.

  11. Biomechanical Evaluation of Four Methods for Internal Fixation of Comminuted Subtrochanteric Fractures.

    PubMed

    Wang, Jie; Ma, Jian-Xiong; Jia, Hao-Bo; Chen, Yang; Yang, Yang; Ma, Xin-Long

    2016-05-01

    Subtrochanteric fractures are common and result in significant morbidity and mortality. Various kinds of implants have been used to fix it. The aim of this study was to compare the biomechanical performance of PFN, DHS, DCS, and the PFLP in the treatment of subtrochanteric comminuted fractures.A total of 32 antiseptic human femurs from 16 donors were randomly allocated to 4 groups for fixation with PFN, DHS, DCS, and PFLP. A 2-cm cylindrical bone fragment was removed 1 cm below the lesser trochanter to simulate OTA/AO 32-C3.2 post instrumentation fracture. All specimens in single-leg stance situation were preloaded 5 times at 100 N in the axial direction to eliminate the time effect of relaxation and settling, followed by cyclic testing at a rate of 1 Hz with stepwise increasing load. Keeping the valley load at a constant level of 100 N during the entire cyclic test, the peak load, starting at 200 N, was increased by 100 N at 300-cycle steps until a maximum of 1500 cycles or until failure of the bone-implant construct occurred. Each specimen was kept unloaded under 100 N compression for 30 minutes between the 300-cycle steps.Femoral head displacement after 1500 cycles was 1.09 mm ± 0.13 for PFN, 1.78 mm ± 0.25 for DHS, 2.63 mm ± 0.46 for DCS, and 2.26 mm ± 0.16 for PFLP, with significant difference between any 2 implants (P < 0.01). The required load to reach 1-mm femoral head displacement was 563.04 N ± 158.34 for PFN, 485.73 N ± 147.27 for DHS, 258.44 N ± 97.23 for DCS, and 332.68 N ± 100.34 for PFLP. Significant differences were detected between any 2 implants (P < 0.001), except between DCS and PFLP and between DHS and PFN. The number of cycles until 1-mm femoral head displacement was 1458 ± 277 for PFN, 908 ± 184 for DHS, 369 ± 116 for DCS, and 603 ± 162 for PFLP. Significant differences were detected between any 2 implants (P < 0.01), except between DCS and PFLP.From biomechanical point of view, comminuted subtrochanteric fractures OTA/AO 32-C3.2 revealed in the current test setup highest fixation strength with PFN, followed by DHS, PFLP, and DCS.

  12. Biomechanical Evaluation of Four Methods for Internal Fixation of Comminuted Subtrochanteric Fractures

    PubMed Central

    Wang, Jie; Ma, Jian-xiong; Jia, Hao-bo; Chen, Yang; Yang, Yang; Ma, Xin-long

    2016-01-01

    Abstract Subtrochanteric fractures are common and result in significant morbidity and mortality. Various kinds of implants have been used to fix it. The aim of this study was to compare the biomechanical performance of PFN, DHS, DCS, and the PFLP in the treatment of subtrochanteric comminuted fractures. A total of 32 antiseptic human femurs from 16 donors were randomly allocated to 4 groups for fixation with PFN, DHS, DCS, and PFLP. A 2-cm cylindrical bone fragment was removed 1 cm below the lesser trochanter to simulate OTA/AO 32-C3.2 post instrumentation fracture. All specimens in single-leg stance situation were preloaded 5 times at 100 N in the axial direction to eliminate the time effect of relaxation and settling, followed by cyclic testing at a rate of 1 Hz with stepwise increasing load. Keeping the valley load at a constant level of 100 N during the entire cyclic test, the peak load, starting at 200 N, was increased by 100 N at 300-cycle steps until a maximum of 1500 cycles or until failure of the bone-implant construct occurred. Each specimen was kept unloaded under 100 N compression for 30 minutes between the 300-cycle steps. Femoral head displacement after 1500 cycles was 1.09 mm ± 0.13 for PFN, 1.78 mm ± 0.25 for DHS, 2.63 mm ± 0.46 for DCS, and 2.26 mm ± 0.16 for PFLP, with significant difference between any 2 implants (P < 0.01). The required load to reach 1-mm femoral head displacement was 563.04 N ± 158.34 for PFN, 485.73 N ± 147.27 for DHS, 258.44 N ± 97.23 for DCS, and 332.68 N ± 100.34 for PFLP. Significant differences were detected between any 2 implants (P < 0.001), except between DCS and PFLP and between DHS and PFN. The number of cycles until 1-mm femoral head displacement was 1458 ± 277 for PFN, 908 ± 184 for DHS, 369 ± 116 for DCS, and 603 ± 162 for PFLP. Significant differences were detected between any 2 implants (P < 0.01), except between DCS and PFLP. From biomechanical point of view, comminuted subtrochanteric fractures OTA/AO 32-C3.2 revealed in the current test setup highest fixation strength with PFN, followed by DHS, PFLP, and DCS. PMID:27175636

  13. Evaluation of existing district health management information systems a case study of the district health systems in Kenya.

    PubMed

    Odhiambo-Otieno, George W

    2005-09-01

    This paper discusses some of the issues and challenges of implementing appropriate and coordinated District Health Management Information System (DHMIS) in environments dependent on external support especially when insufficient attention has been given to the sustainability of systems. It also discusses fundamental issues which affect the usability of DHMIS to support District Health System (DHS), including meeting user needs and user education in the use of information for management; and the need for integration of data from all health-providing and related organizations in the district. This descriptive cross-sectional study was carried out in three DHSs in Kenya. Data was collected through use of questionnaires, focus group discussions and review of relevant literature, reports and operational manuals of the studied DHMISs. Key personnel at the DHS level were not involved in the development and implementation of the established systems. The DHMISs were fragmented to the extent that their information products were bypassing the very levels they were created to serve. None of the DHMISs was computerized. Key resources for DHMIS operation were inadequate. The adequacy of personnel was 47%, working space 40%, storage space 34%, stationery 20%, 73% of DHMIS staff were not trained, management support was 13%. Information produced was 30% accurate, 19% complete, 26% timely, 72% relevant; the level of confidentiality and use of information at the point of collection stood at 32% and 22% respectively and information security at 48%. Basic DHMIS equipment for information processing was not available. This inhibited effective and efficient provision of information services. An effective DHMIS is essential for DHS planning, implementation, monitoring and evaluation activities. Without accurate, timely, relevant and complete information the existing information systems are not capable of facilitating the DHS managers in their day-today operational management. The existing DHMISs were found not supportive of the DHS managers' strategic and operational management functions. Consequently DHMISs were found to be plagued by numerous designs, operational, resources and managerial problems. There is an urgent need to explore the possibilities of computerizing the existing manual systems to take advantage of the potential uses of microcomputers for DHMIS operations within the DHS. Information system designers must also address issues of cooperative partnership in information activities, systems compatibility and sustainability.

  14. Creating a Mix of Spooks and Suits: A New Role for Intelligence

    DTIC Science & Technology

    2003-03-01

    organizational structure the chapter defines the new role intelligence will play in DHS. B . PAVING THE WAY FOR DHS In June 2002 , President Bush...foreword by B . H . Liddell Hart (London: Oxford University Press, 1963) 84. 134 Channell, 1. 55 terrorists threats to Americans, their infrastructure...provided in Section 212 of the Agricultural Bioterrorism Protection Act of 2002 (7 U.S.C. § 8401), as amended by Section 1709( b ) of the Act

  15. 2006 National Small Business Conference - Meeting DOD/DHS Mission Needs in the 21st Century

    DTIC Science & Technology

    2006-05-10

    Untitled Document National Small Business Conference.html[7/7/2016 1:35:33 PM] National Small Business Conference "Meeting DoD/DHS Mission Needs in...Defense Systems (Will be available soon) Panel: Program Manager’s Perspective on Small Business Contributions to Major Programs • Mr. Michael Hoeffler...Vice President, Future Naval Capability, Raytheon Company Small Business Success Story Panel: • Mr. Jay Boyce, Foster-Miller, Inc. (Will be

  16. High sensitivity background absorption measurements in semiconductors

    NASA Astrophysics Data System (ADS)

    Giannini, Nathan; Silva, Junior R.; Wang, Chengao; Albrecht, Alexander R.; Melgaard, Seth D.; Sheik-Bahae, Mansoor

    2015-03-01

    Laser cooling in InGaP|GaAs double heterostructures (DHS) has been a sought after goal. Even though very high external quantum efficiency (EQE) has been achieved, background absorption has remained a bottleneck in achieving net cooling. The purpose of this study is to gain more insight into the source of the background absorption for InGaP|GaAs DHS as well as GaAs|AlGaAs DBRs by employing an excite-probe thermal Z-scan measurement.

  17. Modeling, Simulation, and Analysis for State and Local Emergency Planning and Response: Concept of Operations

    DTIC Science & Technology

    2009-01-01

    must be considered for each threat. The Department of Homeland Security (DHS) has defined 15 National Planning Scenarios ( NPSs ), along with a...considered how to incorporate the 15 NPSs and the Target Capabilities List developed by DHS. Finally, we considered the work being done by Dr. Charles...suite of models and other tools hampers effective planning and re- sponse for all hazards, including the NPSs . The ES community has many meth- ods

  18. Comparison of Intertrochanteric Fracture Fixation with Dynamic Hip Screw and Bipolar Hemiarthroplasty Techniques

    PubMed Central

    Emami, Mohamad; Manafi, Alireza; Hashemi, Behrooz; Nemati, Ali; Safari, Saeed

    2013-01-01

    Background: At present, there is no consensus on an appropriate treatment modality for intertrochanteric fractures in the elderly with background diseases. The aim of the present study was to compare treatment outcomes of intertrochanteric fractures reduced with dynamic hip screws (DHS) and bipolar hemiarthroplasty in elderly patients with background medical conditions. Methods: In this randomized clinical trial, 60 patients with intertrochanteric fractures, who were 45-60 years old, were randomly divided into DHS and bipolar groups. After treatment, the two groups were compared in relation to complications and mortality rates, functional status using the Harris Hip Score (HHS), range of movement and severity of pain using the visual analogue score (VAS). Results: HHS (86±9 vs. 75±7.6), range of flexion (105±11 degrees vs. 90±17 degrees) and external rotation (35±7 degrees vs. 20±7 degrees) were significantly higher in the bipolar group compared to the DHS group (P<0.05). However, there were no significant differences in pain severity between the two groups. Conclusion: Reduction of intertrochanteric fractures in elderly patients with background medical conditions is more effective and less problematic with the bipolar technique compared to DHS and is better tolerated by patients, because this technique is associated with improvements in functional status and hip joint movement range. PMID:25207277

  19. Measurement of Tip Apex Distance and Migration of Lag Screws and Novel Blade Screw Used for the Fixation of Intertrochanteric Fractures.

    PubMed

    Yang, Jesse Chieh-Szu; Chen, Hsin-Chang; Lai, Yu-Shu; Cheng, Cheng-Kung

    2017-01-01

    Fixation with a dynamic hip screw (DHS) is one of the most common methods for stabilizing intertrochanteric fractures, except for unstable and reverse oblique fracture types. However, failure is often observed in osteoporotic patients whereby the lag screw effectively 'cuts out' through the weak bone. Novel anti-migration blades have been developed to be used in combination with a lag screw ('Blade Screw') to improve the fixation strength in osteoporotic intertrochanteric fractures. An in-vitro biomechanical study and a retrospective clinical study were performed to evaluate lag screw migration when using the novel Blade Screw and a traditional threaded DHS. The biomechanical study showed both the Blade Screw and DHS displayed excessive migration (≥10 mm) before reaching 20,000 loading cycles in mild osteoporotic bone, but overall migration of the Blade Screw was significantly less (p ≤ 0.03). Among the patients implanted with a Blade Screw in the clinical study, there was no significant variation in screw migration at 3-months follow-up (P = 0.12). However, the patient's implanted with a DHS did display significantly greater migration (P<0.001) than those implanted with the Blade Screw. In conclusion, the Blade Screw stabilizes the bone fragments during dynamic loading so as to provide significantly greater resistance to screw migration in patients with mild osteoporosis.

  20. Discrepancies between UN models and DHS survey estimates of maternal orphan prevalence: insights from analyses of survey data from Zimbabwe

    PubMed Central

    Robertson, L; Gregson, S; Madanhire, C; Walker, N; Mushati, P; Garnett, G; Nyamukapa, C

    2008-01-01

    Objectives: Model-based estimates of maternal (but not paternal) orphanhood are higher than those based on data from demographic and health surveys (DHS). We investigate the consistency of reporting of parental survival status in data from Manicaland, Zimbabwe. Methods: We compared estimates of paternal and maternal orphan prevalence in three rounds of a prospective household census in Manicaland (1998–2005) with estimates from DHS surveys and UNAIDS model projections. We investigated the consistency of reporting of parental survival status across the three rounds and compared estimates of adult mortality from the orphan data with direct estimates from concurrent follow-up of a general population cohort. Qualitative data were collected on possible reasons for misreporting. Results: Paternal and maternal orphan prevalence is increasing in Zimbabwe. Mothers reported as deceased in round 1 of the Manicaland survey were more likely than fathers to be reported as alive in rounds 2 or 3 (33.3% vs 13.4%). This pattern was most apparent among younger children. The qualitative findings suggest that foster parents sometimes claim adopted children as their natural children. Conclusions: These results are consistent with misreporting of foster parents as natural parents. This appears to be particularly common among foster mothers and could partly explain the discrepancy between mathematical model and DHS estimates of maternal orphanhood. PMID:18647868

  1. Fractionated dynamic headspace sampling in the analysis of matrices of vegetable origin in the food field.

    PubMed

    Liberto, Erica; Cagliero, Cecilia; Cordero, Chiara; Rubiolo, Patrizia; Bicchi, Carlo; Sgorbini, Barbara

    2017-03-17

    Recent technological advances in dynamic headspace sampling (D-HS) and the possibility to automate this sampling method have lead to a marked improvement in its the performance, a strong renewal of interest in it, and have extended its fields of application. The introduction of in-parallel and in-series automatic multi-sampling and of new trapping materials, plus the possibility to design an effective sampling process by correctly applying the breakthrough volume theory, have make profiling more representative, and have enhanced selectivity, and flexibility, also offering the possibility of fractionated enrichment in particular for high-volatility compounds. This study deals with fractionated D-HS ability to produce a sample representative of the volatile fraction of solid or liquid matrices. Experiments were carried out on a model equimolar (0.5mM) EtOH/water solution, comprising 16 compounds with different polarities and volatilities, structures ranging from C5 to C15 and vapor pressures from 4.15kPa (2,3-pentandione) to 0.004kPa (t-β-caryophyllene), and on an Arabica roasted coffee powder. Three trapping materials were considered: Tenax TA™ (TX), Polydimethylsiloxane foam (PDMS), and a three-carbon cartridge Carbopack B/Carbopack C/Carbosieve S-III™ (CBS). The influence of several parameters on the design of successful fractionated D-HS sampling. Including the physical and chemical characteristics of analytes and matrix, trapping material, analyte breakthrough, purge gas volumes, and sampling temperature, were investigated. The results show that, by appropriately choosing sampling conditions, fractionated D-HS sampling, based on component volatility, can produce a fast and representative profile of the matrix volatile fraction, with total recoveries comparable to those obtained by full evaporation D-HS for liquid samples, and very high concentration factors for solid samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. The double burden household in sub-Saharan Africa: maternal overweight and obesity and childhood undernutrition from the year 2000: results from World Health Organization Data (WHO) and Demographic Health Surveys (DHS).

    PubMed

    Wojcicki, Janet M

    2014-10-31

    Previous studies have characterized an increasing trend of double burden households, or households with individuals experiencing both undernutrition and obesity, in countries undergoing a nutrition transition. Although most prior studies indicate the prevalence of double burden households is highest in middle-income countries, there is some support for an increase in double burden households in sub-Saharan African countries as well. Using data from the Demographic Health Surveys (DHS) and the World Health Organization (WHO), the prevalence of double burden households in sub-Saharan African countries was calculated and the associations between prevalence of overweight/obese adults and underweight, stunted and wasted children were evaluated at the country and household (DHS only) levels. Restricted analyses and frequencies were calculated using urban-only datasets. Surveys from 28 African countries were available using WHO data and 26 from the DHS surveys. Only surveys that were conducted after 2000 were included in analyses. Using the WHO datasets, there were inverse associations between the prevalence of overweight and obesity in adults and underweight, stunting and wasting in children. Correspondingly, there were positive associations between adult underweight and child underweight, stunting and wasting. These associations were not significant in a smaller sample size using urban-only surveys. The prevalence of double burden households in DHS datasets was low: under 5 percent for obese mothers and underweight, stunted or wasted child pairs with a slightly higher percentage for overweight mothers and children with undernutrition. Restricting the analysis to urban only populations did not increase the frequencies of double burden households significantly. There was a low prevalence of double burden households in recent data from sub-Saharan Africa. Countries that have a high prevalence of child undernutrition correspondingly have a high prevalence of adult underweight and low prevalence of adult overweight and obesity.

  3. Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

    PubMed

    Divers, Jasmin; Palmer, Nicholette D; Langefeld, Carl D; Brown, W Mark; Lu, Lingyi; Hicks, Pamela J; Smith, S Carrie; Xu, Jianzhao; Terry, James G; Register, Thomas C; Wagenknecht, Lynne E; Parks, John S; Ma, Lijun; Chan, Gary C; Buxbaum, Sarah G; Correa, Adolfo; Musani, Solomon; Wilson, James G; Taylor, Herman A; Bowden, Donald W; Carr, John Jeffrey; Freedman, Barry I

    2017-12-08

    Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences. To identify genes associated with CAC in AAs with type 2 diabetes (T2D), a genome-wide association study (GWAS) was performed using the Illumina 5 M chip in 691 African American-Diabetes Heart Study participants (AA-DHS), with replication in 205 Jackson Heart Study (JHS) participants with T2D. Genetic association tests were performed on the genotyped and 1000 Genomes-imputed markers separately for each study, and combined in a meta-analysis. Single nucleotide polymorphisms (SNPs), rs11353135 (2q22.1), rs16879003 (6p22.3), rs5014012, rs58071836 and rs10244825 (all on chromosome 7), rs10918777 (9q31.2), rs13331874 (16p13.3) and rs4459623 (18q12.1) were associated with presence and/or quantity of CAC in the AA-DHS and JHS, with meta-analysis p-values ≤8.0 × 10 -7 . The strongest result in AA-DHS alone was rs6491315 in the 13q32.1 region (parameter estimate (SE) = -1.14 (0.20); p-value = 9.1 × 10 -9 ). This GWAS peak replicated a previously reported AA-DHS CAC admixture signal (rs7492028, LOD score 2.8). Genetic association between SNPs on chromosomes 2, 6, 7, 9, 16 and 18 and CAC were detected in AAs with T2D from AA-DHS and replicated in the JHS. These data support a role for genetic variation on these chromosomes as contributors to CAC in AAs with T2D, as well as to variation in CAC between populations of African and European ancestry.

  4. The seasonal cycle of diabatic heat storage in the Pacific Ocean

    USGS Publications Warehouse

    White, Warren B.; Cayan, D.R.; Niiler, P.P.; Moisan, J.; Lagerloef, G.; Bonjean, F.; Legler, D.

    2005-01-01

    This study quantifies uncertainties in closing the seasonal cycle of diabatic heat storage (DHS) over the Pacific Ocean from 20??S to 60??N through the synthesis of World Ocean Circulation Experiment (WOCE) reanalysis products from 1993 to 1999. These products are DHS from Scripps Institution of Oceanography (SIO); near-surface geostrophic and Ekman currents from Earth and Space Research (ESR); and air-sea heat fluxes from Comprehensive Ocean-Atmosphere Data Set (COADS), National Centers for Environmental Prediction (NCEP), and European Center for Mid-Range Weather Forecasts (ECMWF). With these products, we compute residual heat budget components by differencing long-term monthly means from the long-term annual mean. This allows the seasonal cycle of the DHS tendency to be modeled. Everywhere latent heat flux residuals dominate sensible heat flux residuals, shortwave heat flux residuals dominate longwave heat flux residuals, and residual Ekman heat advection dominates residual geostrophic heat advection, with residual dissipation significant only in the Kuroshio-Oyashio current extension. The root-mean-square (RMS) of the differences between observed and model residual DHS tendencies (averaged over 10??latitude-by-20??longitude boxes) is <20 W m-2 in the interior ocean and <100 W m-2 in the Kuroshio-Oyashio current extension. This reveals that the residual DHS tendency is driven everywhere by some mix of residual latent heat flux, shortwave heat flux, and Ekman heat advection. Suppressing bias errors in residual air-sea turbulent heat fluxes and Ekman heat advection through minimization of the RMS differences reduces the latter to <10 W m-2 over the interior ocean and <25 W m -2 in the Kuroshio-Oyashio current extension. This reveals air-sea temperature and specific humidity differences from in situ surface marine weather observations to be a principal source of bias error, overestimated over most of ocean but underestimated near the Intertropical Convergence Zone. ?? 2005 Elsevier Ltd. All rights reserved.

  5. Improving the quality of adult mortality data collected in demographic surveys: validation study of a new siblings' survival questionnaire in Niakhar, Senegal.

    PubMed

    Helleringer, Stéphane; Pison, Gilles; Masquelier, Bruno; Kanté, Almamy Malick; Douillot, Laetitia; Duthé, Géraldine; Sokhna, Cheikh; Delaunay, Valérie

    2014-05-01

    In countries with limited vital registration, adult mortality is frequently estimated using siblings' survival histories (SSHs) collected during Demographic and Health Surveys (DHS). These data are affected by reporting errors. We developed a new SSH questionnaire, the siblings' survival calendar (SSC). It incorporates supplementary interviewing techniques to limit omissions of siblings and uses an event history calendar to improve reports of dates and ages. We hypothesized that the SSC would improve the quality of adult mortality data. We conducted a retrospective validation study among the population of the Niakhar Health and Demographic Surveillance System in Senegal. We randomly assigned men and women aged 15-59 y to an interview with either the DHS questionnaire or the SSC. We compared SSHs collected in each group to prospective data on adult mortality collected in Niakhar. The SSC reduced respondents' tendency to round reports of dates and ages to the nearest multiple of five or ten ("heaping"). The SSC also had higher sensitivity in recording adult female deaths: among respondents whose sister(s) had died at an adult age in the past 15 y, 89.6% reported an adult female death during SSC interviews versus 75.6% in DHS interviews (p = 0.027). The specificity of the SSC was similar to that of the DHS questionnaire, i.e., it did not increase the number of false reports of deaths. However, the SSC did not improve the reporting of adult deaths among the brothers of respondents. Study limitations include sample selectivity, limited external validity, and multiple testing. The SSC has the potential to collect more accurate SSHs than the questionnaire used in DHS. Further research is needed to assess the effects of the SSC on estimates of adult mortality rates. Additional validation studies should be conducted in different social and epidemiological settings. Controlled-Trials.com ISRCTN06849961

  6. National Aviation Security Policy, Strategy, and Mode-Specific Plans: Background and Considerations for Congress

    DTIC Science & Technology

    2008-01-02

    aviation security . The approach to aviation security was largely shaped by past events, such as the bombing of Pan Am flight 103 in December 1988, rather...2001 attacks, U.S. aviation security policy and strategy was closely linked to the changes called for in the Aviation and Transportation Security Act...sensitive thus limiting public discourse on the DHS strategy for aviation security . However, in June 2006 President Bush directed the DHS to establish and

  7. In Support of the Common Defense: A Homeland Defense and Security Journal. Volume 2

    DTIC Science & Technology

    2013-06-01

    out in our minds, it is worth remembering historic actions taken by the Army in support of civil authorities in cases like the Mississippi River...controlled by the state governor, who in most cases , places them on State Active Duty (SAD) for response. The CSTs are the only unit in the Guard...disseminate this classified information. There are reported cases where the FBI did not accept DHS security clearances; and others where DHS required

  8. Biosynthesis of the Caenorhabditis elegans dauer pheromone.

    PubMed

    Butcher, Rebecca A; Ragains, Justin R; Li, Weiqing; Ruvkun, Gary; Clardy, Jon; Mak, Ho Yi

    2009-02-10

    To sense its population density and to trigger entry into the stress-resistant dauer larval stage, Caenorhabditis elegans uses the dauer pheromone, which consists of ascaroside derivatives with short, fatty acid-like side chains. Although the dauer pheromone has been studied for 25 years, its biosynthesis is completely uncharacterized. The daf-22 mutant is the only known mutant defective in dauer pheromone production. Here, we show that daf-22 encodes a homolog of human sterol carrier protein SCPx, which catalyzes the final step in peroxisomal fatty acid beta-oxidation. We also show that dhs-28, which encodes a homolog of the human d-bifunctional protein that acts just upstream of SCPx, is also required for pheromone production. Long-term daf-22 and dhs-28 cultures develop dauer-inducing activity by accumulating less active, long-chain fatty acid ascaroside derivatives. Thus, daf-22 and dhs-28 are required for the biosynthesis of the short-chain fatty acid-derived side chains of the dauer pheromone and link dauer pheromone production to metabolic state.

  9. Comparing Estimates of Multiple and Concurrent Partnerships Across Population Based Surveys: Implications for Combination HIV Prevention

    PubMed Central

    Morris, Martina; Leslie-Cook, Ayn; Akom, Eniko; Stephen, Aloo; Sherard, Donna

    2014-01-01

    We compare estimates of multiple and concurrent sexual partnerships from Demographic and Health Surveys (DHS) with comparable Population Services International (PSI) surveys in four African countries (Kenya, Lesotho, Uganda, Zambia). DHS data produce significantly lower estimates of all indicators for both sexes in all countries. PSI estimates of multiple partnerships are 1.7 times higher [1.4 for men (M), 3.0 for women (W)], cumulative prevalence of concurrency is 2.4 times higher (2.2 M, 2.7 W), the point prevalence of concurrency is 3.5 times higher (3.5 M, 3.3 W), and the fraction of multi-partnered persons who report concurrency last year is 1.4 times higher (1.6 M, 0.9 W). These findings provide strong empirical evidence that DHS surveys systematically underestimate levels of multiple and concurrent partnerships. The underestimates will contaminate both empirical analyses of the link between sexual behavior and HIV infection, and theoretical models for combination prevention that use these data for inputs. PMID:24077973

  10. Comparing Estimates of Multiple and Concurrent Partnerships Across Population Based Surveys: Implications for Combination HIV Prevention.

    PubMed

    Morris, Martina; Vu, Lung; Leslie-Cook, Ayn; Akom, Eniko; Stephen, Aloo; Sherard, Donna

    2014-04-01

    We compare estimates of multiple and concurrent sexual partnerships from Demographic and Health Surveys (DHS) with comparable Population Services International (PSI) surveys in four African countries (Kenya, Lesotho, Uganda, Zambia). DHS data produce significantly lower estimates of all indicators for both sexes in all countries. PSI estimates of multiple partnerships are 1.7 times higher [1.4 for men (M), 3.0 for women (W)], cumulative prevalence of concurrency is 2.4 times higher (2.2 M, 2.7 W), the point prevalence of concurrency is 3.5 times higher (3.5 M, 3.3 W), and the fraction of multi-partnered persons who report concurrency last year is 1.4 times higher (1.6 M, 0.9 W). These findings provide strong empirical evidence that DHS surveys systematically underestimate levels of multiple and concurrent partnerships. The underestimates will contaminate both empirical analyses of the link between sexual behavior and HIV infection, and theoretical models for combination prevention that use these data for inputs.

  11. Decision Making in the Management of Extracapsular Fractures of the Proximal Femur - is the Dynamic Hip Screw the Prevailing Gold Standard?

    PubMed

    Jacob, Joshua; Desai, Ankit; Trompeter, Alex

    2017-01-01

    Currently, approximately half of all hip fractures are extracapsular, with an incidence as high as 50 in 100,000 in some countries. The common classification systems fail to explain the logistics of fracture classification and whether they all behave in the same manner. The Muller AO classification system is a useful platform to delineate stable and unstable fractures. The Dynamic hip screw (DHS) however, has remained the 'gold standard' implant of choice for application in all extracapsular fractures. The DHS relies on the integrity and strength of the lateral femoral wall as well as the postero-medial fragment. An analysis of several studies indicates significant improvements in design and techniques to ensure a better outcome with intramedullary nails. This article reviews the historical trends that helped to evolve the DHS implant as well as discussing if the surgeon should remain content with this implant. We suggest that the gold standard surgical management of extracapsular fractures can, and should, evolve.

  12. Discrete harmony search algorithm for scheduling and rescheduling the reprocessing problems in remanufacturing: a case study

    NASA Astrophysics Data System (ADS)

    Gao, Kaizhou; Wang, Ling; Luo, Jianping; Jiang, Hua; Sadollah, Ali; Pan, Quanke

    2018-06-01

    In this article, scheduling and rescheduling problems with increasing processing time and new job insertion are studied for reprocessing problems in the remanufacturing process. To handle the unpredictability of reprocessing time, an experience-based strategy is used. Rescheduling strategies are applied for considering the effect of increasing reprocessing time and the new subassembly insertion. To optimize the scheduling and rescheduling objective, a discrete harmony search (DHS) algorithm is proposed. To speed up the convergence rate, a local search method is designed. The DHS is applied to two real-life cases for minimizing the maximum completion time and the mean of earliness and tardiness (E/T). These two objectives are also considered together as a bi-objective problem. Computational optimization results and comparisons show that the proposed DHS is able to solve the scheduling and rescheduling problems effectively and productively. Using the proposed approach, satisfactory optimization results can be achieved for scheduling and rescheduling on a real-life shop floor.

  13. Probabilistic risk analysis and terrorism risk.

    PubMed

    Ezell, Barry Charles; Bennett, Steven P; von Winterfeldt, Detlof; Sokolowski, John; Collins, Andrew J

    2010-04-01

    Since the terrorist attacks of September 11, 2001, and the subsequent establishment of the U.S. Department of Homeland Security (DHS), considerable efforts have been made to estimate the risks of terrorism and the cost effectiveness of security policies to reduce these risks. DHS, industry, and the academic risk analysis communities have all invested heavily in the development of tools and approaches that can assist decisionmakers in effectively allocating limited resources across the vast array of potential investments that could mitigate risks from terrorism and other threats to the homeland. Decisionmakers demand models, analyses, and decision support that are useful for this task and based on the state of the art. Since terrorism risk analysis is new, no single method is likely to meet this challenge. In this article we explore a number of existing and potential approaches for terrorism risk analysis, focusing particularly on recent discussions regarding the applicability of probabilistic and decision analytic approaches to bioterrorism risks and the Bioterrorism Risk Assessment methodology used by the DHS and criticized by the National Academies and others.

  14. The Relationship between Resettlement and Birth Rates: The Case of Gambella, Ethiopia.

    PubMed

    Adugna, Aynalem; Kloos, Helmut

    2016-07-01

    This study aims to examine the possible impacts of resettlement on birth rates by using the length of stay variable in the 2000 Demographic and Health Survey (DHS). Data in all three rounds of Gambella Administrative Region's Demographic and Health Surveys (DHS) are analyzed. The neighboring administrative region of Benishangul-Gumuz is used as a control. The multivariate analysis of variance (MANOVA) is applied with duration of residence as a categorical independent variable. The statistical software SAS is used. In a univariate analysis of Gambella's DHS 2000, duration of residence has a significant effect on mothers' age at first birth (p < 0.001), the number of children born within the five years of the survey (p<0.001), and the total number of children ever born (P<0.001). In the MANOVA analysis, the duration effect on all three is also statistically significant (p<0.001). Resettlement had a disruptive effect on birth rates among females who were just coming into marriageable ages in places of origin but were resettled to Gambella. Although the disruptive effects waned over time, the initial shortfall resulted in reduced overall lifetime births for settler women who were not past the midpoint of their reproductive years at arrival. Based on the reproductive history of female settlers with different duration of residence in the resettlement schemes, we recommend the reinstatement of the length of residence question in future DHS surveys in Ethiopia to allow a longitudinal tracking of demographic trends among nonnative populations.

  15. Sorption-induced effects of humic substances on mass transfer of organic pollutants through aqueous diffusion boundary layers: the example of water/air exchange.

    PubMed

    Ramus, Ksenia; Kopinke, Frank-Dieter; Georgi, Anett

    2012-02-21

    This study examines the effect of dissolved humic substances (DHS) on the rate of water-gas exchange of organic compounds under conditions where diffusion through the aqueous boundary layer is rate-determining. A synthetic surfactant was applied for comparison. Mass-transfer coefficients were determined from the rate of depletion of the model compounds by means of an apparatus containing a stirred aqueous solution with continuous purging of the headspace above the solution. In addition, experiments with continuous passive dosing of analytes into the water phase were conducted to simulate a system where thermodynamic activity of the chemical in the aqueous phase is identical in the presence and absence of DHS. The experimental results show that DHS and surfactants can affect water-gas exchange rates by the superposition of two mechanisms: (1) hydrodynamic effects due to surface film formation ("surface smoothing"), and (2) sorption-induced effects. Whether sorption accelerates or retards mass transfer depends on its effect on the thermodynamic activity of the pollutant in the aqueous phase. Mass transfer will be retarded if the activity (or freely dissolved concentration) of the pollutant is decreased due to sorption. If it remains unchanged (e.g., due to fast equilibration with a sediment acting as a large source phase), then DHS and surfactant micelles can act as an additional shuttle for the pollutants, enhancing the flux through the boundary layer.

  16. Simplified Asset Indices to Measure Wealth and Equity in Health Programs: A Reliability and Validity Analysis Using Survey Data From 16 Countries

    PubMed Central

    Chakraborty, Nirali M; Fry, Kenzo; Behl, Rasika; Longfield, Kim

    2016-01-01

    ABSTRACT Background: Social franchising programs in low- and middle-income countries have tried using the standard wealth index, based on the Demographic and Health Survey (DHS) questionnaire, in client exit interviews to assess clients’ relative wealth compared with the national wealth distribution to ensure equity in service delivery. The large number of survey questions required to capture the wealth index variables have proved cumbersome for programs. Methods: Using an adaptation of the Delphi method, we developed shortened wealth indices and in February 2015 consulted 15 stakeholders in equity measurement. Together, we selected the best of 5 alternative indices, accompanied by 2 measures of agreement (percent agreement and Cohen’s kappa statistic) comparing wealth quintile assignment in the new indices to the full DHS index. The panel agreed that reducing the number of assets was more important than standardization across countries because a short index would provide strong indication of client wealth and be easier to collect and use in the field. Additionally, the panel agreed that the simplified index should be highly correlated with the DHS for each country (kappa ≥ 0.75) for both national and urban-specific samples. We then revised indices for 16 countries and selected the minimum number of questions and question options required to achieve a kappa statistic ≥ 0.75 for both national and urban populations. Findings: After combining the 5 wealth quintiles into 3 groups, which the expert panel deemed more programmatically meaningful, reliability between the standard DHS wealth index and each of 3 simplified indices was high (median kappa = 0.81, 086, and 0.77, respectively, for index B that included only the common questions from the DHS VI questionnaire, index D that included the common questions plus country-specific questions, and index E that found the shortest list of common and country-specific questions that met the minimum reliability criteria of kappa ≥ 0.75). Index E was the simplified index of choice because it was reliable in national and urban contexts while requiring the fewest number of survey questions—6 to 18 per country compared with 25 to 47 in the original DHS wealth index (a 66% average reduction). Conclusion: Social franchise clinics and other types of service delivery programs that want to assess client wealth in relation to a national or urban population can do so with high reliability using a short questionnaire. Future uses of the simplified asset questionnaire include a mobile application for rapid data collection and analysis. PMID:27016550

  17. Simplified Asset Indices to Measure Wealth and Equity in Health Programs: A Reliability and Validity Analysis Using Survey Data From 16 Countries.

    PubMed

    Chakraborty, Nirali M; Fry, Kenzo; Behl, Rasika; Longfield, Kim

    2016-03-01

    Social franchising programs in low- and middle-income countries have tried using the standard wealth index, based on the Demographic and Health Survey (DHS) questionnaire, in client exit interviews to assess clients' relative wealth compared with the national wealth distribution to ensure equity in service delivery. The large number of survey questions required to capture the wealth index variables have proved cumbersome for programs. Using an adaptation of the Delphi method, we developed shortened wealth indices and in February 2015 consulted 15 stakeholders in equity measurement. Together, we selected the best of 5 alternative indices, accompanied by 2 measures of agreement (percent agreement and Cohen's kappa statistic) comparing wealth quintile assignment in the new indices to the full DHS index. The panel agreed that reducing the number of assets was more important than standardization across countries because a short index would provide strong indication of client wealth and be easier to collect and use in the field. Additionally, the panel agreed that the simplified index should be highly correlated with the DHS for each country (kappa ≥ 0.75) for both national and urban-specific samples. We then revised indices for 16 countries and selected the minimum number of questions and question options required to achieve a kappa statistic ≥ 0.75 for both national and urban populations. After combining the 5 wealth quintiles into 3 groups, which the expert panel deemed more programmatically meaningful, reliability between the standard DHS wealth index and each of 3 simplified indices was high (median kappa = 0.81, 086, and 0.77, respectively, for index B that included only the common questions from the DHS VI questionnaire, index D that included the common questions plus country-specific questions, and index E that found the shortest list of common and country-specific questions that met the minimum reliability criteria of kappa ≥ 0.75). Index E was the simplified index of choice because it was reliable in national and urban contexts while requiring the fewest number of survey questions-6 to 18 per country compared with 25 to 47 in the original DHS wealth index (a 66% average reduction). Social franchise clinics and other types of service delivery programs that want to assess client wealth in relation to a national or urban population can do so with high reliability using a short questionnaire. Future uses of the simplified asset questionnaire include a mobile application for rapid data collection and analysis. © Chakraborty et al.

  18. Constructing vulnerabilty and protective measures indices for the enhanced critical infrastructure protection program.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fisher, R. E.; Buehring, W. A.; Whitfield, R. G.

    2009-10-14

    The US Department of Homeland Security (DHS) has directed its Protective Security Advisors (PSAs) to form partnerships with the owners and operators of assets most essential to the Nation's well being - a subclass of critical infrastructure and key resources (CIKR) - and to conduct site visits for these and other high-risk assets as part of the Enhanced Critical Infrastructure Protection (ECIP) Program. During each such visit, the PSA documents information about the facility's current CIKR protection posture and overall security awareness. The primary goals for ECIP site visits (DHS 2009) are to: (1) inform facility owners and operators ofmore » the importance of their facilities as an identified high-priority CIKR and the need to be vigilant in light of the ever-present threat of terrorism; (2) identify protective measures currently in place at these facilities, provide comparisons of CIKR protection postures across like assets, and track the implementation of new protective measures; and (3) enhance existing relationships among facility owners and operators; DHS; and various Federal, State, local tribal, and territorial partners. PSAs conduct ECIP visits to assess overall site security; educate facility owners and operators about security; help owners and operators identify gaps and potential improvements; and promote communication and information sharing among facility owners and operators, DHS, State governments, and other security partners. Information collected during ECIP visits is used to develop metrics; conduct sector-by-sector and cross-sector vulnerability comparisons; identify security gaps and trends across CIKR sectors and subsectors; establish sector baseline security survey results; and track progress toward improving CIKR security through activities, programs, outreach, and training (Snyder 2009). The data being collected are used in a framework consistent with the National Infrastructure Protection Plan (NIPP) risk criteria (DHS 2009). The NIPP framework incorporates consequence, threat, and vulnerability components and addresses all hazards. The analysis of the vulnerability data needs to be reproducible, support risk analysis, and go beyond protection. It also needs to address important security/vulnerability topics, such as physical security, cyber security, systems analysis, and dependencies and interdependencies. This report provides an overview of the approach being developed to estimate vulnerability and provide vulnerability comparisons for sectors and subsectors. the information will be used to assist DHS in analyzing existing protective measures and vulnerability at facilities, to identify potential ways to reduce vulnerabilities, and to assist in preparing sector risk estimates. The owner/operator receives an analysis of the data collected for a specific asset, showing a comparison between the facility's protection posture/vulnerability index and those of DHS sector/subsector sites visited. This comparison gives the owner/operator an indication of the asset's security strengths and weaknesses that may be contributing factors to its vulnerability and protection posture. The information provided to the owner/operator shows how the asset compares to other similar assets within the asset's sector or subsector. A 'dashboard' display is used to illustrate the results in a convenient format. The dashboard allows the owner/operator to analyze the implementation of additional protective measures and to illustrate how such actions would impact the asset's Protective Measures Index (PMI) or Vulnerability Index (VI).« less

  19. Aeromedical Transport Operations Using Helicopters during the 2016 Kumamoto Earthquake in Japan.

    PubMed

    Motomura, Tomokazu; Hirabayashi, Atsushi; Matsumoto, Hisashi; Yamauchi, Nobutaka; Nakamura, Mitsunobu; Machida, Hiroshi; Fujizuka, Kenji; Otsuka, Naomi; Satoh, Tomoko; Anan, Hideaki; Kondo, Hisayoshi; Koido, Yuichi

    2018-01-01

    More than 6,000 people died in the Great Hanshin (Kobe) Earthquake in 1995, and it was later reported that there were around 500 preventable trauma deaths. In response, the Japanese government developed the helicopter emergency medical service in 2001, known in Japan as the "Doctor-Heli" (DH), which had 46 DHs and 2 private medical helicopters as of April 2016. DHs transport physicians and nurses to provide pre-hospital medical care at the scene of medical emergencies. Following lessons learned in the Great East Japan Earthquake in 2011, a research group in the Ministry of Health, Labour and Welfare developed a command and control system for the DH fleet as well as the Disaster Relief Aircraft Management System Network (D-NET), which uses a satellite communications network to monitor the location of the fleet and weather in real-time during disasters. During the Kumamoto Earthquake disaster in April 2016, 75 patients were transported by 13 DHs and 1 private medical helicopter in the first 5 days. When medical demand for the DHs exceeded supply, 5 patients, 8 patients, and 1 patient were transported by Self-Defense Force, Fire Department, and Coast Guard helicopters, respectively. Of the 89 patients who were transported, 30 (34%) had trauma, 3 (3%) had pulmonary embolisms caused by sleeping in vehicles, and 17 (19%) were pregnant women or newborns. This was the first time that the command and control system for aeromedical transport and D-NET, established after the Great East Japan Earthquake in 2011, were operated in an actual large-scale disaster. Aeromedical transport by DHs and helicopters belonging to several other organizations was accomplished smoothly because the commanders of the involved organizations could communicate directly with each other in person within the Aviation Coordination Section of the prefectural government office. However, ongoing challenges in the detailed operating methods for aeromedical transport were highlighted and include improving shared knowledge and training across the organizational framework. These are particularly important issues to address given the Nankai Trough and Tokyo inland earthquakes that are predicted for the near future in Japan.

  20. Calcium- and Nitric Oxide-Dependent Nuclear Accumulation of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase in Response to Long Chain Bases in Tobacco BY-2 Cells.

    PubMed

    Testard, Ambroise; Da Silva, Daniel; Ormancey, Mélanie; Pichereaux, Carole; Pouzet, Cécile; Jauneau, Alain; Grat, Sabine; Robe, Eugénie; Brière, Christian; Cotelle, Valérie; Mazars, Christian; Thuleau, Patrice

    2016-10-01

    Sphinganine or dihydrosphingosine (d18:0, DHS), one of the most abundant free sphingoid long chain bases (LCBs) in plants, is known to induce a calcium-dependent programmed cell death (PCD) in plants. In addition, in tobacco BY-2 cells, it has been shown that DHS triggers a rapid production of H 2 O 2 and nitric oxide (NO). Recently, in analogy to what is known in the animal field, plant cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPC), a ubiquitous enzyme involved in glycolysis, has been suggested to fulfill other functions associated with its oxidative post-translational modifications such as S-nitrosylation on cysteine residues. In particular, in mammals, stress signals inducing NO production promote S-nitrosylation of GAPC and its subsequent translocation into the nucleus where the protein participates in the establishment of apoptosis. In the present study, we investigated the behavior of GAPC in tobacco BY-2 cells treated with DHS. We found that upon DHS treatment, an S-nitrosylated form of GAPC accumulated in the nucleus. This accumulation was dependent on NO production. Two genes encoding GAPCs, namely Nt(BY-2)GAPC1 and Nt(BY-2)GAPC2, were cloned. Transient overexpression of Nt(BY-2)GAPC-green fluorescent protein (GFP) chimeric constructs indicated that both proteins localized in the cytoplasm as well as in the nucleus. Mutating into serine the two cysteine residues thought to be S-nitrosylated in response to DHS did not modify the localization of the proteins, suggesting that S-nitrosylation of GAPCs was probably not necessary for their nuclear relocalization. Interestingly, using Förster resonance energy transfer experiments, we showed that Nt(BY-2)GAPCs interact with nucleic acids in the nucleus. When GAPCs were mutated on their cysteine residues, their interaction with nucleic acids was abolished, suggesting a role for GAPCs in the protection of nucleic acids against oxidative stress. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  1. Improving the Quality of Adult Mortality Data Collected in Demographic Surveys: Validation Study of a New Siblings' Survival Questionnaire in Niakhar, Senegal

    PubMed Central

    Helleringer, Stéphane; Pison, Gilles; Masquelier, Bruno; Kanté, Almamy Malick; Douillot, Laetitia; Duthé, Géraldine; Sokhna, Cheikh; Delaunay, Valérie

    2014-01-01

    Background In countries with limited vital registration, adult mortality is frequently estimated using siblings' survival histories (SSHs) collected during Demographic and Health Surveys (DHS). These data are affected by reporting errors. We developed a new SSH questionnaire, the siblings' survival calendar (SSC). It incorporates supplementary interviewing techniques to limit omissions of siblings and uses an event history calendar to improve reports of dates and ages. We hypothesized that the SSC would improve the quality of adult mortality data. Methods and Findings We conducted a retrospective validation study among the population of the Niakhar Health and Demographic Surveillance System in Senegal. We randomly assigned men and women aged 15–59 y to an interview with either the DHS questionnaire or the SSC. We compared SSHs collected in each group to prospective data on adult mortality collected in Niakhar. The SSC reduced respondents' tendency to round reports of dates and ages to the nearest multiple of five or ten (“heaping”). The SSC also had higher sensitivity in recording adult female deaths: among respondents whose sister(s) had died at an adult age in the past 15 y, 89.6% reported an adult female death during SSC interviews versus 75.6% in DHS interviews (p = 0.027). The specificity of the SSC was similar to that of the DHS questionnaire, i.e., it did not increase the number of false reports of deaths. However, the SSC did not improve the reporting of adult deaths among the brothers of respondents. Study limitations include sample selectivity, limited external validity, and multiple testing. Conclusions The SSC has the potential to collect more accurate SSHs than the questionnaire used in DHS. Further research is needed to assess the effects of the SSC on estimates of adult mortality rates. Additional validation studies should be conducted in different social and epidemiological settings. Trial Registration Controlled-Trials.com ISRCTN06849961 Please see later in the article for the Editors' Summary PMID:24866715

  2. Cultivation of methanogenic community from 2-km deep subseafloor coalbeds using a continuous-flow bioreactor

    NASA Astrophysics Data System (ADS)

    Imachi, H.; Tasumi, E.; Morono, Y.; Ito, M.; Takai, K.; Inagaki, F.

    2013-12-01

    Deep subseafloor environments associated with hydrocarbon reservoirs have been least explored by previous scientific drilling and hence the nature of deep subseafloor life and its ecological roles in the carbon cycle remain largely unknown. In this study, we performed cultivation of subseafloor methanogenic communities using a continuous-flow bioreactor with polyurethane sponges, called down-flow hanging sponge (DHS) reactor. The sample used for the reactor cultivation was obtained from 2 km-deep coalbeds off the Shimokita Peninsula of Japan, the northwestern Pacific, during the Integrated Ocean Drilling Program (IODP) Expedition 337 using a riser drilling technology of the drilling vessel Chikyu. The coalbed samples were incubated anaerobically in the DHS reactor at the in-situ temperature of 40°C. Synthetic seawater supplemented with a tiny amount of yeast extract, acetate, propionate and butyrate was provided into the DHS reactor. After 34 days of the bioreactor operation, a small production of methane was observed. The methane concentration was gradually increased and the stable carbon isotopic composition of methane was consistency 13C-depleted during the bioreactor operation, indicating the occurrence of microbial methanogenesis. Microscopic observation showed that the enrichment culture contained a variety of microorganisms, including methanogen-like rod-shaped cells with F420 auto-fluorescence. Interestingly, many spore-like particles were observed in the bioreactor enrichment. Phylogenetic analysis of 16S rRNA genes showed the growth of phylogenetically diverse bacteria and archaea in the DHS reactor. Predominant archaeal components were closely related to hydrogenotrophic methanogens within the genus Methanobacterium. Some predominant bacteria were related to the spore-formers within the class Clostridia, which are overall in good agreement with microscopic observations. By analyzing ion images using a nano-scale secondary ion mass spectrometry (NanoSIMS), 13C-bicarbonate incorporation of rod-shaped methanogens, as well as 13C-acetate incorporation of other cells, was observed. These microbiological data obtained from the DHS reactor generally support a geochemical indication that microbial processes contribute to the biogeochemical carbon cycle associated with 2 km-coalbeds in the deep subseafloor biosphere.

  3. In vitro evaluation of acaricidal activity of novel green silver nanoparticles against deltamethrin resistance Rhipicephalus (Boophilus) microplus.

    PubMed

    Avinash, B; Venu, R; Alpha Raj, M; Srinivasa Rao, K; Srilatha, Ch; Prasad, T N V K V

    2017-04-15

    An investigation was undertaken to study, for the first time, in vitro acaricidal activity of green silver nanoparticles on deltamethrin resistance Rhipicephalus (Boophilus) microplus. The compounds tested were neem coated silver nanoparticles (N-Ag NPs), deltamethrin neem coated silver nanoparticles (DN-Ag NPs), 2, 3 dehydrosalannol (2,3 DHS), 2, 3 DHS coated silver nanoparticles (2, 3-DHS-Ag NPs), Quercetin dihydrate (QDH) and QDH coated silver nanoparticles (QDH-Ag NPs). Also included in this study, for the purpose of comparison, were neem leaf extract (NLE), silver nitrate (AgNO 3 ) and deltamethrin (D). Acaricidal activity on larvae and adults of R. (B.) microplus was tested by larval packet test (LPT) and adult immersion test (AIT) respectively. In the LPT, 100% mortality was obtained at concentrations (ppm) of 360, 6000, 260, 200, 50, 300, 85, 600 and 200 for the compounds, D, NLE, Ag NO 3 , N-Ag NPs, DN-Ag NPs, 2, 3 DHS, 2, 3 DHS-Ag NPs, QDH, QDH-Ag NPs respectively. In AIT, the proportions of mortality and oviposition inhibition were proportionate but the reproductive index was inversely proportional to the concentration of the compounds used. The effect of DN-Ag NPs on mortality was the highest (93.33%) at 50ppm concentration. The mean reproductive index (0.01) and oviposition inhibition (99.16%) values were statistically significant when compared to control group. DN-Ag NPs showed significantly (P<0.05) lower LC 50 (3.87ppm; 21.95ppm) and LC 99 (53.05ppm; 90.06ppm) values against both the larvae and adults of R. (B.) microplus. The oviposition inhibiting ability of various compounds was determined to assess the reproductive performance of adult female ticks. The DN-Ag NPs had potent oviposition inhibitory activity with significantly lower IC 50 and IC 99 values compared to the rest of the treatments at 0.034 and 51.07ppm respectively. These results showed that the DN-Ag NPs had significant acaricidal activity against R. (B.) microplus. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Child anthropometry data quality from Demographic and Health Surveys, Multiple Indicator Cluster Surveys, and National Nutrition Surveys in the West Central Africa region: are we comparing apples and oranges?

    PubMed Central

    Corsi, Daniel J.; Perkins, Jessica M.; Subramanian, S. V.

    2017-01-01

    ABSTRACT Background: There has been limited work comparing survey characteristics and assessing the quality of child anthropometric data from population-based surveys. Objective: To investigate survey characteristics and indicators of quality of anthropometric data in children aged 0–59 months from 23 countries in the West Central Africa region. Methods: Using established methodologies and criteria to examine child age, sex, height, and weight, we conducted a comprehensive assessment and scoring of the quality of anthropometric data collected in 100 national surveys. Results: The Multiple Indicator Cluster Surveys (MICS) and Demographic and Health Surveys (DHS) collected data from a greater number of younger children than older children while the opposite was found for the National Nutrition Surveys (NNS). Missing or implausible height/weight data proportions were 12% and 8% in MICS and DHS compared to 3% in NNS. Average data quality scores were 14 in NNS, 33 in DHS, and 41 in MICS. Conclusions: Although our metric of data quality suggests that data from the NNS appear more consistent and robust, it is equally important to consider its disadvantages related to access and lack of broader socioeconomic information. In comparison, the DHS and MICS are publicly-accessable for research and provide socioeconomic context essential for assessing and addressing the burden of undernutrition within and between countries. The strengths and weaknesses of data from these three sources should be carefully considered when seeking to determine the burden of child undernutrition and its variation within countries. PMID:28641057

  5. Measuring Coverage in MNCH: Tracking Progress in Health for Women and Children Using DHS and MICS Household Surveys

    PubMed Central

    Hancioglu, Attila; Arnold, Fred

    2013-01-01

    Household surveys are the primary data source of coverage indicators for children and women for most developing countries. Most of this information is generated by two global household survey programmes—the USAID-supported Demographic and Health Surveys (DHS) and the UNICEF-supported Multiple Indicator Cluster Surveys (MICS). In this review, we provide an overview of these two programmes, which cover a wide range of child and maternal health topics and provide estimates of many Millennium Development Goal indicators, as well as estimates of the indicators for the Countdown to 2015 initiative and the Commission on Information and Accountability for Women's and Children's Health. MICS and DHS collaborate closely and work through interagency processes to ensure that survey tools are harmonized and comparable as far as possible, but we highlight differences between DHS and MICS in the population covered and the reference periods used to measure coverage. These differences need to be considered when comparing estimates of reproductive, maternal, newborn, and child health indicators across countries and over time and we discuss the implications of these differences for coverage measurement. Finally, we discuss the need for survey planners and consumers of survey results to understand the strengths, limitations, and constraints of coverage measurements generated through household surveys, and address some technical issues surrounding sampling and quality control. We conclude that, although much effort has been made to improve coverage measurement in household surveys, continuing efforts are needed, including further research to improve and refine survey methods and analytical techniques. PMID:23667333

  6. Training safer orthopedic surgeons. Construct validation of a virtual-reality simulator for hip fracture surgery.

    PubMed

    Akhtar, Kashif; Sugand, Kapil; Sperrin, Matthew; Cobb, Justin; Standfield, Nigel; Gupte, Chinmay

    2015-01-01

    Virtual-reality (VR) simulation in orthopedic training is still in its infancy, and much of the work has been focused on arthroscopy. We evaluated the construct validity of a new VR trauma simulator for performing dynamic hip screw (DHS) fixation of a trochanteric femoral fracture. 30 volunteers were divided into 3 groups according to the number of postgraduate (PG) years and the amount of clinical experience: novice (1-4 PG years; less than 10 DHS procedures); intermediate (5-12 PG years; 10-100 procedures); expert (> 12 PG years; > 100 procedures). Each participant performed a DHS procedure and objective performance metrics were recorded. These data were analyzed with each performance metric taken as the dependent variable in 3 regression models. There were statistically significant differences in performance between groups for (1) number of attempts at guide-wire insertion, (2) total fluoroscopy time, (3) tip-apex distance, (4) probability of screw cutout, and (5) overall simulator score. The intermediate group performed the procedure most quickly, with the lowest fluoroscopy time, the lowest tip-apex distance, the lowest probability of cutout, and the highest simulator score, which correlated with their frequency of exposure to running the trauma lists for hip fracture surgery. This study demonstrates the construct validity of a haptic VR trauma simulator with surgeons undertaking the procedure most frequently performing best on the simulator. VR simulation may be a means of addressing restrictions on working hours and allows trainees to practice technical tasks without putting patients at risk. The VR DHS simulator evaluated in this study may provide valid assessment of technical skill.

  7. Fish consumption and advisory awareness among older Wisconsin fishermen.

    PubMed

    Imm, Pamela; Anderson, Henry A; Schrank, Candy; Knobeloch, Lynda

    2013-06-01

    The provision of fish consumption advice issued by the Wisconsin Department of Health Services (DHS) and Department of Natural Resources (DNR) has evolved over the past 40 years. In 2010, DHS received a US Environmental Protection Agency Great Lakes Restoration Initiative (GLRI) grant to evaluate existing advisory approaches, identify gaps, and adapt current communication approaches. Previous research conducted by DHS found that older, male anglers eat more sport fish and have higher body burdens of persistent contaminants found in fish than other groups. As part of the GLRI, Wisconsin DHS and DNR aimed to engage this subpopulation and improve communication by using an Internet-based survey to collect information about fishing habits, consumption, and advisory awareness. At the end of the survey, participants were provided with answers to advisory questions and links to relevant online information. From fall 2011 through spring 2012, 827 men aged 50 and older completed this survey. Nearly all fishermen were aware of the existence of consumption advisories. Although awareness was high, penetration of traditional outreach materials was low with fewer than 35% having seen any of the pamphlets featured in the survey. Knowledge of the advisories was significantly higher among residents of counties along Lakes Michigan and Superior and among more frequent sport fish consumers. Men who were aware of these advisories were significantly more likely to have modified their consumption behavior. Wisconsin's experience suggests general awareness among older male anglers. Participation in the online survey and responses to sources of advisory information supports the need to expand the current outreach program to reach and inform the fish-consuming public.

  8. Child anthropometry data quality from Demographic and Health Surveys, Multiple Indicator Cluster Surveys, and National Nutrition Surveys in the West Central Africa region: are we comparing apples and oranges?

    PubMed

    Corsi, Daniel J; Perkins, Jessica M; Subramanian, S V

    2017-01-01

    There has been limited work comparing survey characteristics and assessing the quality of child anthropometric data from population-based surveys. To investigate survey characteristics and indicators of quality of anthropometric data in children aged 0-59 months from 23 countries in the West Central Africa region. Using established methodologies and criteria to examine child age, sex, height, and weight, we conducted a comprehensive assessment and scoring of the quality of anthropometric data collected in 100 national surveys. The Multiple Indicator Cluster Surveys (MICS) and Demographic and Health Surveys (DHS) collected data from a greater number of younger children than older children while the opposite was found for the National Nutrition Surveys (NNS). Missing or implausible height/weight data proportions were 12% and 8% in MICS and DHS compared to 3% in NNS. Average data quality scores were 14 in NNS, 33 in DHS, and 41 in MICS. Although our metric of data quality suggests that data from the NNS appear more consistent and robust, it is equally important to consider its disadvantages related to access and lack of broader socioeconomic information. In comparison, the DHS and MICS are publicly-accessable for research and provide socioeconomic context essential for assessing and addressing the burden of undernutrition within and between countries. The strengths and weaknesses of data from these three sources should be carefully considered when seeking to determine the burden of child undernutrition and its variation within countries.

  9. Preliminary report for analysis of genome wide mutations from four ciprofloxacin resistant B. anthracis Sterne isolates generated by Illumina, 454 sequencing and microarrays for DHS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jaing, Crystal; Vergez, Lisa; Hinckley, Aubree

    2011-06-21

    The objective of this project is to provide DHS a comprehensive evaluation of the current genomic technologies including genotyping, Taqman PCR, multiple locus variable tandem repeat analysis (MLVA), microarray and high-throughput DNA sequencing in the analysis of biothreat agents from complex environmental samples. As the result of a different DHS project, we have selected for and isolated a large number of ciprofloxacin resistant B. anthracis Sterne isolates. These isolates vary in the concentrations of ciprofloxacin that they can tolerate, suggesting multiple mutations in the samples. In collaboration with University of Houston, Eureka Genomics and Oak Ridge National Laboratory, we analyzedmore » the ciprofloxacin resistant B. anthracis Sterne isolates by microarray hybridization, Illumina and Roche 454 sequencing to understand the error rates and sensitivity of the different methods. The report provides an assessment of the results and a complete set of all protocols used and all data generated along with information to interpret the protocols and data sets.« less

  10. Predicting enhancer activity and variant impact using gkm-SVM.

    PubMed

    Beer, Michael A

    2017-09-01

    We participated in the Critical Assessment of Genome Interpretation eQTL challenge to further test computational models of regulatory variant impact and their association with human disease. Our prediction model is based on a discriminative gapped-kmer SVM (gkm-SVM) trained on genome-wide chromatin accessibility data in the cell type of interest. The comparisons with massively parallel reporter assays (MPRA) in lymphoblasts show that gkm-SVM is among the most accurate prediction models even though all other models used the MPRA data for model training, and gkm-SVM did not. In addition, we compare gkm-SVM with other MPRA datasets and show that gkm-SVM is a reliable predictor of expression and that deltaSVM is a reliable predictor of variant impact in K562 cells and mouse retina. We further show that DHS (DNase-I hypersensitive sites) and ATAC-seq (assay for transposase-accessible chromatin using sequencing) data are equally predictive substrates for training gkm-SVM, and that DHS regions flanked by H3K27Ac and H3K4me1 marks are more predictive than DHS regions alone. © 2017 Wiley Periodicals, Inc.

  11. Performance evaluation of the sulfur-redox-reaction-activated up-flow anaerobic sludge blanket and down-flow hanging sponge anaerobic/anoxic sequencing batch reactor system for municipal sewage treatment.

    PubMed

    Hatamoto, Masashi; Ohtsuki, Kota; Maharjan, Namita; Ono, Shinya; Dehama, Kazuya; Sakamoto, Kenichi; Takahashi, Masanobu; Yamaguchi, Takashi

    2016-03-01

    A sulfur-redox-reaction-activated up-flow anaerobic sludge blanket (UASB) and down-flow hanging sponge (DHS) system, combined with an anaerobic/anoxic sequencing batch reactor (A2SBR), has been used for municipal sewage treatment for over 2 years. The present system achieved a removal rate of 95±14% for BOD, 74±22% for total nitrogen, and 78±25% for total phosphorus, including low water temperature conditions. Sludge conversion rates during the operational period were 0.016 and 0.218 g-VSS g-COD-removed(-1) for the UASB, and DHS, respectively, which are similar to a conventional UASB-DHS system, which is not used of sulfur-redox-reaction, for sewage treatment. Using the sulfur-redox reaction made advanced treatment of municipal wastewater with minimal sludge generation possible, even in winter. Furthermore, the occurrence of a unique phenomenon, known as the anaerobic sulfur oxidation reaction, was confirmed in the UASB reactor under the winter season. Copyright © 2016. Published by Elsevier Ltd.

  12. Decision Making in the Management of Extracapsular Fractures of the Proximal Femur – is the Dynamic Hip Screw the Prevailing Gold Standard?

    PubMed Central

    Jacob, Joshua; Desai, Ankit; Trompeter, Alex

    2017-01-01

    Currently, approximately half of all hip fractures are extracapsular, with an incidence as high as 50 in 100,000 in some countries. The common classification systems fail to explain the logistics of fracture classification and whether they all behave in the same manner. The Muller AO classification system is a useful platform to delineate stable and unstable fractures. The Dynamic hip screw (DHS) however, has remained the ‘gold standard’ implant of choice for application in all extracapsular fractures. The DHS relies on the integrity and strength of the lateral femoral wall as well as the postero-medial fragment. An analysis of several studies indicates significant improvements in design and techniques to ensure a better outcome with intramedullary nails. This article reviews the historical trends that helped to evolve the DHS implant as well as discussing if the surgeon should remain content with this implant. We suggest that the gold standard surgical management of extracapsular fractures can, and should, evolve. PMID:29290858

  13. Drinking Water Consequences Tools. A Literature Review

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pasqualini, Donatella

    2016-05-12

    In support of the goals of Department of Homeland Security’s (DHS) National Protection and Programs Directorate and the Federal Emergency Management Agency, the DHS Office of Science and Technology is seeking to develop and/or modify consequence assessment tools to enable drinking water systems owner/operators to estimate the societal and economic consequences of drinking water disruption due to the threats and hazards. This work will expand the breadth of consequence estimation methods and tools using the best-available data describing water distribution infrastructure, owner/assetlevel economic losses, regional-scale economic activity, and health. In addition, this project will deploy the consequence methodology and capabilitymore » within a Web-based platform. This report is intended to support DHS effort providing a review literature review of existing assessment tools of water and wastewater systems consequences to disruptions. The review includes tools that assess water systems resilience, vulnerability, and risk. This will help to understand gaps and limitations of these tools in order to plan for the development of the next-generation consequences tool for water and waste water systems disruption.« less

  14. Low-energy proton induced M X-ray production cross sections for 70Yb, 81Tl and 82Pb

    NASA Astrophysics Data System (ADS)

    Shehla; Mandal, A.; Kumar, Ajay; Roy Chowdhury, M.; Puri, Sanjiv; Tribedi, L. C.

    2018-07-01

    The cross sections for production of Mk (k = Mξ, Mαβ, Mγ, Mm1) X-rays of 70Yb, 81Tl and 82Pb induced by 50-250 keV protons have been measured in the present work. The experimental cross sections have been compared with the earlier reported values and those calculated using the ionization cross sections based on the ECPSSR (Perturbed (P) stationary(S) state(S), incident ion energy (E) loss, Coulomb (C) deflection and relativistic (R) correction) model, the X-ray emission rates based on the Dirac-Fock model, the fluorescence and Coster-Kronig yields based on the Dirac-Hartree-Slater (DHS) model. In addition, the present measured proton induced X-ray production cross sections have also been compared with those calculated using the Dirac-Hartree-Slater (DHS) model based ionization cross sections and those based on the Plane wave Born Approximation (PWBA). The measured M X-ray production cross sections are, in general, found to be higher than the ECPSSR and DHS model based values and lower than the PWBA model based cross sections.

  15. Si based GeSn light emitter: mid-infrared devices in Si photonics

    NASA Astrophysics Data System (ADS)

    Yu, S. Q.; Ghetmiri, S. A.; Du, W.; Margetis, J.; Zhou, Y.; Mosleh, A.; Al-Kabi, S.; Nazzal, A.; Sun, G.; Soref, R. A.; Tolle, J.; Li, B.; Naseem, H. A.

    2015-02-01

    Ge1-xSnx/Ge thin films and Ge/Ge1-xSnx/Ge n-i-p double heterostructure (DHS) have been grown using commercially available reduced pressure chemical vapor deposition (RPCVD) reactor. The Sn compositional material and optical characteristics have been investigated. A direct bandgap GeSn material has been identified with Sn composition of 10%. The GeSn DHS samples were fabricated into LED devices. Room temperature electroluminescence spectra were studied. A maximum emission power of 28mW was obtained with 10% Sn LED under the injection current density of 800 A/cm2.

  16. Annual Report on the Activities and Publications of the DHS-DNDO-NTNFC Sponsored Post-doctoral Fellow at Los Alamos National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rim, Jung Ho; Tandon, Lav

    This report is a summary of the projects Jung Rim is working on as a DHS postdoctoral fellow at Los Alamos National Laboratory. These research projects are designed to explore different radioanalytical methods to support nuclear forensics applications. The current projects discussed here include development of alpha spectroscopy method for 240/239Pu Isotopic ratio measurement, non-destructive uranium assay method using gamma spectroscopy, and 236U non-destructive uranium analysis using FRAM code. This report documents the work that has been performed since the start of the postdoctoral appointment.

  17. Homeland security and public health: role of the Department of Veterans Affairs, the US Department of Homeland Security, and implications for the public health community.

    PubMed

    Koenig, Kristi L

    2003-01-01

    The terrorist attacks of 11 September 2001 led to the largest US Government transformation since the formation of the Department of Defense following World War II. More than 22 different agencies, in whole or in part, and >170,000 employees were reorganized to form a new Cabinet-level Department of Homeland Security (DHS), with the primary mission to protect the American homeland. Legislation enacted in November 2002 transferred the entire Federal Emergency Management Agency and several Department of Health and Human Services (HHS) assets to DHS, including the Office of Emergency Response, and oversight for the National Disaster Medical System, Strategic National Stockpile, and Metropolitan Medical Response System. This created a potential separation of "health" and "medical" assets between the DHS and HHS. A subsequent presidential directive mandated the development of a National Incident Management System and an all-hazard National Response Plan. While no Department of Veterans Affairs (VA) assets were targeted for transfer, the VA remains the largest integrated healthcare system in the nation with important support roles in homeland security that complement its primary mission to provide care to veterans. The Emergency Management Strategic Healthcare Group (EMSHG) within the VA's medical component, the Veteran Health Administration (VHA), is the executive agent for the VA's Fourth Mission, emergency management. In addition to providing comprehensive emergency management services to the VA, the EMSHG coordinates medical back-up to the Department of Defense, and assists the public via the National Disaster Medical System and the National Response Plan. This article describes the VA's role in homeland security and disasters, and provides an overview of the ongoing organizational and operational changes introduced by the formation of the new DHS. Challenges and opportunities for public health are highlighted.

  18. Measuring equity in utilization of emergency obstetric care at Wolisso Hospital in Oromiya, Ethiopia: a cross sectional study

    PubMed Central

    2013-01-01

    Introduction Improving equity in access to services for the treatment of complications that arise during pregnancy and childbirth, namely Emergency Obstetric Care (EmOC), is fundamental if maternal and neonatal mortality are to be reduced. Consequently, there is a growing need to monitor equity in access to EmOC. The objective of this study was to develop a simple questionnaire to measure equity in utilization of EmOC at Wolisso Hospital, Ethiopia and compare the wealth status of EmOC users with women in the general population. Methods Women in the Ethiopia 2005 Demographic and Health Survey (DHS) constituted our reference population. We cross-tabulated DHS wealth variables against wealth quintiles. Five variables that differentiated well across quintiles were selected to create a questionnaire that was administered to women at discharge from the maternity from January to August 2010. This was used to identify inequities in utilization of EmOC by comparison with the reference population. Results 760 women were surveyed. An a posteriori comparison of these 2010 data to the 2011 DHS dataset, indicated that women using EmOC were wealthier and more likely to be urban dwellers. On a scale from 0 (poorest) to 15 (wealthiest), 31% of women in the 2011 DHS sample scored less than 1 compared with 0.7% in the study population. 70% of women accessing EmOC belonged to the richest quintile with only 4% belonging to the poorest two quintiles. Transportation costs seem to play an important role. Conclusions We found inequity in utilization of EmOC in favour of the wealthiest. Assessing and monitoring equitable utilization of maternity services is feasible using this simple tool. PMID:23607604

  19. Requirements Definition for ORNL Trusted Corridors Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walker, Randy M; Hill, David E; Smith, Cyrus M

    2008-02-01

    The ORNL Trusted Corridors Project has several other names: SensorNet Transportation Pilot; Identification and Monitoring of Radiation (in commerce) Shipments (IMR(ic)S); and Southeastern Transportation Corridor Pilot (SETCP). The project involves acquisition and analysis of transportation data at two mobile and three fixed inspection stations in five states (Kentucky, Mississippi, South Carolina, Tennessee, and Washington DC). Collaborators include the State Police organizations that are responsible for highway safety, law enforcement, and incident response. The three states with fixed weigh-station deployments (KY, SC, TN) are interested in coordination of this effort for highway safety, law enforcement, and sorting/targeting/interdiction of potentially non-compliant vehicles/persons/cargo.more » The Domestic Nuclear Detection Office (DNDO) in the U.S. Department of Homeland Security (DHS) is interested in these deployments, as a Pilot test (SETCP) to identify Improvised Nuclear Devices (INDs) in highway transport. However, the level of DNDO integration among these state deployments is presently uncertain. Moreover, DHS issues are considered secondary by the states, which perceive this work as an opportunity to leverage these (new) dual-use technologies for state needs. In addition, present experience shows that radiation detectors alone cannot detect DHS-identified IND threats. Continued SETCP success depends on the level of integration of current state/local police operations with the new DHS task of detecting IND threats, in addition to emergency preparedness and homeland security. This document describes the enabling components for continued SETCP development and success, including: sensors and their use at existing deployments (Section 1); personnel training (Section 2); concept of operations (Section 3); knowledge discovery from the copious data (Section 4); smart data collection, integration and database development, advanced algorithms for multiple sensors, and network communications (Section 5); and harmonization of local, state, and Federal procedures and protocols (Section 6).« less

  20. Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias.

    PubMed

    Ziegler, Patrick; Chahoud, Tuhama; Wilhelm, Thomas; Pällman, Nora; Braig, Melanie; Wiehle, Valeska; Ziegler, Susanne; Schröder, Marcus; Meier, Chris; Kolodzik, Adrian; Rarey, Matthias; Panse, Jens; Hauber, Joachim; Balabanov, Stefan; Brümmendorf, Tim H

    2012-12-01

    Effective inhibition of BCR-ABL tyrosine kinase activity with Imatinib represents a breakthrough in the treatment of patients with chronic myeloid leukemia (CML). However, more than 30 % of patients with CML in chronic phase do not respond adequately to Imatinib and the drug seems not to affect the quiescent pool of BCR-ABL positive leukemic stem and progenitor cells. Therefore, despite encouraging clinical results, Imatinib can still not be considered a curative treatment option in CML. We recently reported downregulation of eukaryotic initiation factor 5A (eIF5A) in Imatinib treated K562 cells. Furthermore, the inhibition of eIF5A by siRNA in combination with Imatinib has been shown to exert synergistic cytotoxic effects on BCR-ABL positive cell lines. Based on the structure of known deoxyhypusine synthase (DHS) inhibitors such as CNI-1493, a drug design approach was applied to develop potential compounds targeting DHS. Here we report the biological evaluation of selected novel (DHSI-15) as compared to established (CNI-1493, deoxyspergualin) DHS inhibitors. We show that upon the compounds tested, DHSI-15 and deoxyspergualin exert strongest antiproliferative effects on BCR-ABL cells including Imatinib resistant mutants. However, this effect did not seem to be restricted to BCR-ABL positive cell lines or primary cells. Both compounds are able to induce apoptosis/necrosis during long term incubation of BCR-ABL positive BA/F3 derivates. Pharmacological synergism can be observed for deoxyspergualin and Imatinib, but not for DHSI-15 and Imatinib. Finally we show that deoxyspergualin is able to inhibit proliferation of CD34+ progenitor cells from CML patients. We conclude that inhibition of deoxyhypusine synthase (DHS) can be supportive for the anti-proliferative treatment of leukemia and merits further investigation including other cancers.

  1. Different relationships between temporal phylogenetic turnover and phylogenetic similarity and in two forests were detected by a new null model.

    PubMed

    Huang, Jian-Xiong; Zhang, Jian; Shen, Yong; Lian, Ju-yu; Cao, Hong-lin; Ye, Wan-hui; Wu, Lin-fang; Bin, Yue

    2014-01-01

    Ecologists have been monitoring community dynamics with the purpose of understanding the rates and causes of community change. However, there is a lack of monitoring of community dynamics from the perspective of phylogeny. We attempted to understand temporal phylogenetic turnover in a 50 ha tropical forest (Barro Colorado Island, BCI) and a 20 ha subtropical forest (Dinghushan in southern China, DHS). To obtain temporal phylogenetic turnover under random conditions, two null models were used. The first shuffled names of species that are widely used in community phylogenetic analyses. The second simulated demographic processes with careful consideration on the variation in dispersal ability among species and the variations in mortality both among species and among size classes. With the two models, we tested the relationships between temporal phylogenetic turnover and phylogenetic similarity at different spatial scales in the two forests. Results were more consistent with previous findings using the second null model suggesting that the second null model is more appropriate for our purposes. With the second null model, a significantly positive relationship was detected between phylogenetic turnover and phylogenetic similarity in BCI at a 10 m×10 m scale, potentially indicating phylogenetic density dependence. This relationship in DHS was significantly negative at three of five spatial scales. This could indicate abiotic filtering processes for community assembly. Using variation partitioning, we found phylogenetic similarity contributed to variation in temporal phylogenetic turnover in the DHS plot but not in BCI plot. The mechanisms for community assembly in BCI and DHS vary from phylogenetic perspective. Only the second null model detected this difference indicating the importance of choosing a proper null model.

  2. Federal technology transfer requirements :a focused study of principal agencies approaches with implications for the Department of Homeland Security.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koker, Denise; Micheau, Jill M.

    2006-07-01

    This report provides relevant information and analysis to the Department of Homeland Security (DHS) that will assist DHS in determining how to meet the requirements of federal technology transfer legislation. These legal requirements are grouped into five categories: (1) establishing an Office of Research and Technology Applications, or providing the functions thereof; (2) information management; (3) enabling agreements with non-federal partners; (4) royalty sharing; and (5) invention ownership/obligations. These five categories provide the organizing framework for this study, which benchmarks other federal agencies/laboratories engaged in technology transfer/transition Four key agencies--the Department of Health & Human Services (HHS), the U.S. Departmentmore » of Agriculture (USDA), the Department of Energy (DOE), and the Department of Defense (DoD)--and several of their laboratories have been surveyed. An analysis of DHS's mission needs for commercializing R&D compared to those agencies/laboratories is presented with implications and next steps for DHS's consideration. Federal technology transfer legislation, requirements, and practices have evolved over the decades as agencies and laboratories have grown more knowledgeable and sophisticated in their efforts to conduct technology transfer and as needs and opinions in the federal sector have changed with regards to what is appropriate. The need to address requirements in a fairly thorough manner has, therefore, resulted in a lengthy paper. There are two ways to find summary information. Each chapter concludes with a summary, and there is an overall ''Summary and Next Steps'' chapter on pages 57-60. For those readers who are unable to read the entire document, we recommend referring to these pages.« less

  3. Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium.

    PubMed

    Njuguna, James T; von Koschitzky, Imke; Gerhardt, Heike; Lämmerhofer, Michael; Choucry, Ali; Pink, Mario; Schmitz-Spahnke, Simone; Bakheit, Mohammed A; Strube, Christina; Kaiser, Annette

    2014-08-01

    East Coast fever (ECF) is a tick-borne disease caused by the parasite Theileria parva which infects cattle. In Sub-Saharan Africa it leads to enormous economic costs. After a bite of a tick, sporozoites invade the host lymphocytes and develop into schizonts. At this stage the parasite transforms host lymphocytes resulting in the clonal expansion of infected lymphocytes. Animals develop a lymphoma like disorder after infection which is rapidly fatal. Hitherto, a few drugs of the quinone type can cure the disease. However, therapy can only be successful after early diagnosis. The genera Theileria and Plasmodium, which includes the causative agent of human malaria, are closely related apicomplexan parasites. Enzymes of the hypusine pathway, a posttranslational modification in eukaryotic initiation factor EIF-5A, have shown to be druggable targets in Plasmodium. We identified the first enzyme of the hypusine pathway from T. parva, the deoxyhypusine synthase (DHS), which is located on chromosome 2 of the Muguga strain. Transcription is significantly increased in schizonts. The expressed T. parva DHS reveals an open reading frame (ORF) of 370 amino acids after expression in Escherichia coli Rosetta cells with a molecular size of 41.26 kDa and a theoretical pI of 5.26. Screening of the Malaria Box which consists of 400 active compounds resulted in a novel heterocyclic compound with a guanyl spacer which reduced the activity of T. parva DHS to 45%. In sum, the guanyl residue seems to be an important lead structure for inhibition of Theileria DHS. Currently, more different guanyl analogues from the Malaria Box are tested in inhibitor experiments to determine their efficacy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies.

    PubMed

    Szentkirályi, András; Völzke, Henry; Hoffmann, Wolfgang; Trenkwalder, Claudia; Berger, Klaus

    2014-06-03

    Our aim was to evaluate the association between the cumulative effect of comorbidity and the risk of restless legs syndrome (RLS) in 2 population-based German cohort studies. The Dortmund Health Study (DHS) (n = 1,312; median follow-up time: 2.1 years) and the Study of Health in Pomerania (SHIP) (n = 4,308; median follow-up time: 5.0 years) were used for the analyses. RLS was assessed at baseline and follow-up according to the RLS minimal criteria. A comorbidity index was calculated as a sum of the following conditions: diabetes, hypertension, myocardial infarction, obesity, stroke, cancer, renal disease, anemia, depression, thyroid disease, and migraine. The relationship between comorbidity and incident RLS was analyzed with multivariate logistic regression models. An increase in the number of comorbid conditions at baseline predicted prevalent RLS (DHS: trend odds ratio [OR] = 1.24, 95% confidence interval [CI] 0.99-1.56; SHIP: trend OR = 1.34, 95% CI 1.18-1.52) and incident RLS (DHS: trend OR = 1.32, 95% CI 1.04-1.68; SHIP: trend OR = 1.59, 95% CI 1.37-1.85) after adjustment for several covariates. The ORs for incident RLS associated with 3 or more comorbid diseases (DHS: OR = 2.51, 95% CI 1.18-5.34; SHIP: OR = 4.30, 95% CI 2.60-7.11) were higher than the ORs for any single disease. Multimorbidity was a strong risk factor for RLS in these 2 population-based cohort studies. The results support the hypothesis that cumulative disease burden is more important than the presence of a specific single disease in the pathophysiology of RLS. © 2014 American Academy of Neurology.

  5. Analysis of volatile compounds responsible for kiwifruit aroma by desiccated headspace gas chromatography-mass spectrometry.

    PubMed

    Zhang, Chun-Yun; Zhang, Qiong; Zhong, Cai-Hong; Guo, Ming-Quan

    2016-04-01

    A new method for desiccated headspace (DHS) sampling of aqueous sample to GC-MS for the analysis of volatile compounds responsible for kiwifruit aroma in different kiwifruit cultivars has been developed based on the complete hydrate formation between the sample solvent (water) with anhydrous salt (calcium chloride) at an elevated temperature (above the boiling point of the aqueous sample) in a non-contact format, which overcame the water-effect challenge to directly introduce aqueous sample into GC-MS analysis. By means of DHS, the volatile compounds in three different kiwifruit cultivars were analyzed and compared under the optimized operating conditions, mainly time and temperature for headspace equilibration, column temperature program for GC-MS measurement. As a result, 20 peaks of volatile compounds responsible for kiwifruit aroma were detected and remarkable differences were found in the relative contents of three major volatile compounds among the three different kiwifruit cultivars, i.e., acetaldehyde, ethanol and furfural. The DHS sampling technique used in the present method can make the GC-MS analysis of volatile compounds in the aqueous sample within complex matrix possible without contaminating the GC-MS instrument. In terms of the analysis of volatile compounds in kiwifruit, the present method enabled a direct measurement on the filtrate of the aqueous kiwifruit pulp, without intermediate trap phase for the extraction of analytes, which will be more reliable and simpler as compared with any other headspace method in use. Thus, DHS coupled with GC-MS will be a new valuable tool available for the kiwifruit related research and organoleptic quality control. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Gait training using a hybrid assistive limb (HAL) attenuates head drop: A case report.

    PubMed

    Miura, Kousei; Koda, Masao; Kadone, Hideki; Kubota, Shigeki; Shimizu, Yukiyo; Kumagai, Hiroshi; Nagashima, Katsuya; Mataki, Kentaro; Fujii, Kengo; Noguchi, Hiroshi; Funayama, Toru; Abe, Tetsuya; Sankai, Yoshiyuki; Yamazaki, Masashi

    2018-06-01

    Dropped head syndrome (DHS) is characterized by a chin-on-chest deformity, which can severely interfere with forward vision and impair activities of daily living. A standardized treatment strategy for DHS has not been established. To our knowledge, this is the first case report describing the efficacy of gait training using a hybrid assistive limb (HAL) for DHS. A 75-year-old man showed apparent head drop in a standing position, resulting in passively reducible chin-on-chest deformity. A radiograph image showed apparent cervical kyphosis. Center of gravity of the head (CGH)-C7 SVA was +115 mm, CL was -40°, and T1S 39°. The patient underwent a treatment program using HAL, in which gait training was mainly performed, 60 min a day, 5 days a week for 2 weeks (10 sessions). After 2-3 sessions, dropped head started to attenuate. At the end of 10 sessions, the patient was able to walk with normal posture and radiograph images showed cervical kyphosis dramatically decreased because of HAL training. CGH-C7 SVA was 42 mm, CL was -1.7°, and T1S was 30°. Three months' outpatient follow-up revealed a slight deterioration of cervical alignment. However, the patient was able to maintain a better cervical alignment than before HAL training and keep walking with forward vision. There were no complications in any HAL treatment session. In conclusion, gait training using HAL is an option for treatment of DHS in addition to previously reported neck extensor muscle training. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Hormone levels in vegetarian and nonvegetarian teenage girls: potential implications for breast cancer risk.

    PubMed

    Persky, V W; Chatterton, R T; Van Horn, L V; Grant, M D; Langenberg, P; Marvin, J

    1992-02-01

    Between September 1984 and June 1985, a total of 75 adolescent girls, 35 vegetarians residing in a Seventh-Day Adventist school and 40 nonvegetarians residing in a private non-Adventist boarding school, underwent measurement of their plasma hormone levels in the follicular and luteal phase of their menstrual cycles as well as dietary intake measured by 3-day food records, medical history, height, and weight. There were no significant differences between vegetarians and nonvegetarians in average age of the girls, weight, body mass index, age at menarche, years since the onset of menstruation, or percentage of girls with ovulatory cycles. Vegetarian girls had significantly higher levels of log follicular estradiol [2.00 +/- 0.27 (SD) versus 1.85 +/- 0.27 pg/ml, P less than or equal to 0.05] and luteal dehydroepiandrosterone sulfate (DHS) (1.88 +/- 0.71 versus 1.45 +/- 0.80 microgram/ml, P less than or equal to 0.05) than nonvegetarian girls. Follicular DHS was higher in vegetarians than in nonvegetarians (1.72 +/- 0.79 versus 1.45 +/- 0.95 microgram/ml), but the difference was not significant. The differences in follicular and luteal DHS, but not the difference in log estradiol, were significant (P less than or equal to 0.05) after controlling for ovulation, smoking, and alcohol intake with multivariable regression analysis. There were no significant differences in testosterone or in percentage free estradiol levels between vegetarians and nonvegetarians. Smoking was significantly associated with follicular and luteal DHS and with percentage free follicular estradiol, while alcohol use was significantly and inversely associated with percentage free follicular estradiol after controlling for other variables. The implications for breast cancer risk are discussed.

  8. Hybrid maize breeding with doubled haploids: I. One-stage versus two-stage selection for testcross performance.

    PubMed

    Longin, C Friedrich H; Utz, H Friedrich; Reif, Jochen C; Schipprack, Wolfgang; Melchinger, Albrecht E

    2006-03-01

    Optimum allocation of resources is of fundamental importance for the efficiency of breeding programs. The objectives of our study were to (1) determine the optimum allocation for the number of lines and test locations in hybrid maize breeding with doubled haploids (DHs) regarding two optimization criteria, the selection gain deltaG(k) and the probability P(k) of identifying superior genotypes, (2) compare both optimization criteria including their standard deviations (SDs), and (3) investigate the influence of production costs of DHs on the optimum allocation. For different budgets, number of finally selected lines, ratios of variance components, and production costs of DHs, the optimum allocation of test resources under one- and two-stage selection for testcross performance with a given tester was determined by using Monte Carlo simulations. In one-stage selection, lines are tested in field trials in a single year. In two-stage selection, optimum allocation of resources involves evaluation of (1) a large number of lines in a small number of test locations in the first year and (2) a small number of the selected superior lines in a large number of test locations in the second year, thereby maximizing both optimization criteria. Furthermore, to have a realistic chance of identifying a superior genotype, the probability P(k) of identifying superior genotypes should be greater than 75%. For budgets between 200 and 5,000 field plot equivalents, P(k) > 75% was reached only for genotypes belonging to the best 5% of the population. As the optimum allocation for P(k)(5%) was similar to that for deltaG(k), the choice of the optimization criterion was not crucial. The production costs of DHs had only a minor effect on the optimum number of locations and on values of the optimization criteria.

  9. Opposite Effects of Dihydrosphingosine 1-Phosphate and Sphingosine 1-Phosphate on Transforming Growth Factor-β/Smad Signaling Are Mediated through the PTEN/PPM1A-dependent Pathway*S⃞

    PubMed Central

    Bu, Shizhong; Kapanadze, Bagrat; Hsu, Tien; Trojanowska, Maria

    2008-01-01

    Transforming growth factor-β (TGF-β) is an important regulator of physiological connective tissue biosynthesis and plays a central role in pathological tissue fibrosis. Previous studies have established that a biologically active lipid mediator, sphingosine 1-phosphate (S1P), mimics some of the profibrotic functions of TGF-β through cross-activation of Smad signaling. Here we report that another product of sphingosine kinase, dihydrosphingosine 1-phosphate (dhS1P), has an opposite role in the regulation of TGF-β signaling. In contrast to S1P, dhS1P inhibits TGF-β-induced Smad2/3 phosphorylation and up-regulation of collagen synthesis. The effects of dhS1P require a lipid phosphatase, PTEN, a key modulator of cell growth and survival. dhS1P stimulates phosphorylation of the C-terminal domain of PTEN and its subsequent translocation into the nucleus. We demonstrate a novel function of nuclear PTEN as a co-factor of the Smad2/3 phosphatase, PPM1A. Complex formation of PTEN with PPM1A does not require the lipid phosphatase activity but depends on phosphorylation of the serine/threonine residues located in the C-terminal domain of PTEN. Upon complex formation with PTEN, PPM1A is protected from degradation induced by the TGF-β signaling. Consequently, overexpression of PTEN abrogates TGF-β-induced Smad2/3 phosphorylation. This study establishes a novel role for nuclear PTEN in the stabilization of PPM1A. PTEN-mediated cross-talk between the sphingolipid and TGF-β signaling pathways may play an important role in physiological and pathological TGF-β signaling. PMID:18482992

  10. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.

    PubMed

    Bu, Shizhong; Kapanadze, Bagrat; Hsu, Tien; Trojanowska, Maria

    2008-07-11

    Transforming growth factor-beta (TGF-beta) is an important regulator of physiological connective tissue biosynthesis and plays a central role in pathological tissue fibrosis. Previous studies have established that a biologically active lipid mediator, sphingosine 1-phosphate (S1P), mimics some of the profibrotic functions of TGF-beta through cross-activation of Smad signaling. Here we report that another product of sphingosine kinase, dihydrosphingosine 1-phosphate (dhS1P), has an opposite role in the regulation of TGF-beta signaling. In contrast to S1P, dhS1P inhibits TGF-beta-induced Smad2/3 phosphorylation and up-regulation of collagen synthesis. The effects of dhS1P require a lipid phosphatase, PTEN, a key modulator of cell growth and survival. dhS1P stimulates phosphorylation of the C-terminal domain of PTEN and its subsequent translocation into the nucleus. We demonstrate a novel function of nuclear PTEN as a co-factor of the Smad2/3 phosphatase, PPM1A. Complex formation of PTEN with PPM1A does not require the lipid phosphatase activity but depends on phosphorylation of the serine/threonine residues located in the C-terminal domain of PTEN. Upon complex formation with PTEN, PPM1A is protected from degradation induced by the TGF-beta signaling. Consequently, overexpression of PTEN abrogates TGF-beta-induced Smad2/3 phosphorylation. This study establishes a novel role for nuclear PTEN in the stabilization of PPM1A. PTEN-mediated cross-talk between the sphingolipid and TGF-beta signaling pathways may play an important role in physiological and pathological TGF-beta signaling.

  11. National Incident Management System (NIMS) Standards Review Panel Workshop Summary Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stenner, Robert D.; Kirk, Jennifer L.; Stanton, James R.

    The importance and need for full compliant implementation of NIMS nationwide was clearly demonstrated during the Hurricane Katrina event, which was clearly expressed in Secretary Chertoff's October 4, 2005 letter addressed to the State's governors. It states, ''Hurricane Katrina was a stark reminder of how critical it is for our nation to approach incident management in a coordinated, consistent, and efficient manner. We must be able to come together, at all levels of government, to prevent, prepare for, respond to, and recover from any emergency or disaster. Our operations must be seamless and based on common incident management doctrine, becausemore » the challenges we face as a nation are far greater than capabilities of any one jurisdiction.'' The NIMS is a system/architecture for organizing response on a ''national'' level. It incorporations ICS as a main component of that structure (i.e., it institutionalizes ICS in NIMS). In a paper published on the NIMS Website, the following statements were made: ''NIMS represents a core set of doctrine, principles, terminology, and organizational processes to enable effective, efficient and collaborative incident management at all levels. To provide the framework for interoperability and compatibility, the NIMS is based on a balance between flexibility and standardization.'' Thus the NIC is challenged with the need to adopt quality SDO generated standards to support NIMS compliance, but in doing so maintain the flexibility necessary so that response operations can be tailored for the specific jurisdictional and geographical needs across the nation. In support of this large and complex challenge facing the NIC, the Pacific Northwest National Laboratory (PNNL) was asked to provide technical support to the NIC, through their DHS Science and Technology ? Standards Portfolio Contract, to help identify, review, and develop key standards for NIMS compliance. Upon examining the challenge, the following general process appears to be a reasonable approach for identifying and establishing existing standards that would be applicable to NIMS compliance. The suggested generalized steps to establishing existing SDO generated standards for NIMS compliance are: (1) establish search criteria from the NIMS and its support documents, (2) search SDO databases to identify key existing nationally and/or internationally recognized standards that have potential application to NIMS compliance needs, (3) review the identified standards against the specific component needs of the NIMS, (4) identify the pertinent aspects/components of those identified standards that clearly address specific NIMS compliance needs, (5) establish a process to adopt the pertinent standards, which includes the generation of formalized FEMA Guidance that identifies the specific NIMS component compliance needs addressed in the respective standard, (6) develop performance criteria for which to measure compliance with the identified NIMS components addressed by the respective adopted standard, and (7) adopt the standard, publish the guidance and performance criteria, and incorporate it into routine FEMA/NIC NIMS management operations. This review process will also help identify real gaps in standards for which new NIMS specific standards should be developed. To jump start this process and hopefully identify some key ''low hanging fruit'' standards the NIC could use to begin such a process, a panel of first-responder experts (familiar with the current standards of common use in the first-responder community) from various response disciplines was formed and a workshop held. The workshop included a pre-workshop information gathering process. This report discusses the workshop and its findings in detail.« less

  12. 78 FR 73202 - Review and Revision of the National Critical Infrastructure Security and Resilience (NCISR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ...This Request for Information (RFI) notice informs the public that the Department of Homeland Security's (DHS) Science and Technology Directorate (S&T) is currently developing a National Critical Infrastructure Security and Resilience Research and Development Plan (NCISR R&D Plan) to conform to the requirements of Presidential Policy Directive 21, Critical Infrastructure Security and Resilience. As part of a comprehensive national review process, DHS solicits public comment on issues or language in the NCISR R&D Plan that need to be included. Critical infrastructure includes both cyber and physical components, systems, and networks for the sixteen established ``critical infrastructures''.

  13. Treatment of natural rubber processing wastewater using a combination system of a two-stage up-flow anaerobic sludge blanket and down-flow hanging sponge system.

    PubMed

    Tanikawa, D; Syutsubo, K; Hatamoto, M; Fukuda, M; Takahashi, M; Choeisai, P K; Yamaguchi, T

    2016-01-01

    A pilot-scale experiment of natural rubber processing wastewater treatment was conducted using a combination system consisting of a two-stage up-flow anaerobic sludge blanket (UASB) and a down-flow hanging sponge (DHS) reactor for more than 10 months. The system achieved a chemical oxygen demand (COD) removal efficiency of 95.7% ± 1.3% at an organic loading rate of 0.8 kg COD/(m(3).d). Bacterial activity measurement of retained sludge from the UASB showed that sulfate-reducing bacteria (SRB), especially hydrogen-utilizing SRB, possessed high activity compared with methane-producing bacteria (MPB). Conversely, the acetate-utilizing activity of MPB was superior to SRB in the second stage of the reactor. The two-stage UASB-DHS system can reduce power consumption by 95% and excess sludge by 98%. In addition, it is possible to prevent emissions of greenhouse gases (GHG), such as methane, using this system. Furthermore, recovered methane from the two-stage UASB can completely cover the electricity needs for the operation of the two-stage UASB-DHS system, accounting for approximately 15% of the electricity used in the natural rubber manufacturing process.

  14. Analysis of a combined heating and cooling system model under different operating strategies

    NASA Astrophysics Data System (ADS)

    Dzierzgowski, Mieczysław; Zwierzchowski, Ryszard

    2017-11-01

    The paper presents an analysis of a combined heating and cooling system model under different operating strategies. Cooling demand for air conditioning purposes has grown steadily in Poland since the early 1990s. The main clients are large office buildings and shopping malls in downtown locations. Increased demand for heat in the summer would mitigate a number of problems regarding District Heating System (DHS) operation at minimum power, affecting the average annual price of heat (in summertime the share of costs related to transport losses is a strong cost factor). In the paper, computer simulations were performed for different supply network water temperature, assuming as input, real changes in the parameters of the DHS (heat demand, flow rates, etc.). On the basis of calculations and taking into account investment costs of the Absorption Refrigeration System (ARS) and the Thermal Energy Storage (TES) system, an optimal capacity of the TES system was proposed to ensure smooth and efficient operation of the District Heating Plant (DHP). Application of ARS with the TES system in the DHS in question increases net profit by 19.4%, reducing the cooling price for consumers by 40%.

  15. Low temperature structural transitions in dipolar hard spheres: The influence on magnetic properties

    NASA Astrophysics Data System (ADS)

    Ivanov, A. O.; Kantorovich, S. S.; Rovigatti, L.; Tavares, J. M.; Sciortino, F.

    2015-06-01

    We investigate the structural chain-to-ring transition at low temperature in a gas of dipolar hard spheres (DHS). Due to the weakening of entropic contribution, ring formation becomes noticeable when the effective dipole-dipole magnetic interaction increases. It results in the redistribution of particles from usually observed flexible chains into flexible rings. The concentration (ρ) of DHS plays a crucial part in this transition: at a very low ρ only chains and rings are observed, whereas even a slight increase of the volume fraction leads to the formation of branched or defect structures. As a result, the fraction of DHS aggregated in defect-free rings turns out to be a non-monotonic function of ρ. The average ring size is found to be a slower increasing function of ρ when compared to that of chains. Both theory and computer simulations confirm the dramatic influence of the ring formation on the ρ-dependence of the initial magnetic susceptibility (χ) when the temperature decreases. The rings due to their zero total dipole moment are irresponsive to a weak magnetic field and drive to the strong decrease of the initial magnetic susceptibility.

  16. Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase–an Essential Enzyme of the Polyamine Metabolism

    PubMed Central

    Krossa, Sebastian; Faust, Annette; Ober, Dietrich; Scheidig, Axel J.

    2016-01-01

    The highly conserved bacterial homospermidine synthase (HSS) is a key enzyme of the polyamine metabolism of many proteobacteria including pathogenic strains such as Legionella pneumophila and Pseudomonas aeruginosa; The unique usage of NAD(H) as a prosthetic group is a common feature of bacterial HSS, eukaryotic HSS and deoxyhypusine synthase (DHS). The structure of the bacterial enzyme does not possess a lysine residue in the active center and thus does not form an enzyme-substrate Schiff base intermediate as observed for the DHS. In contrast to the DHS the active site is not formed by the interface of two subunits but resides within one subunit of the bacterial HSS. Crystal structures of Blastochloris viridis HSS (BvHSS) reveal two distinct substrate binding sites, one of which is highly specific for putrescine. BvHSS features a side pocket in the direct vicinity of the active site formed by conserved amino acids and a potential substrate discrimination, guiding, and sensing mechanism. The proposed reaction steps for the catalysis of BvHSS emphasize cation-π interaction through a conserved Trp residue as a key stabilizer of high energetic transition states. PMID:26776105

  17. Rectifying behavior in the GaN/graded-AlxGa1‑xN/GaN double heterojunction structure

    NASA Astrophysics Data System (ADS)

    Wang, Caiwei; Jiang, Yang; Ma, Ziguang; Zuo, Peng; Yan, Shen; Die, Junhui; Wang, Lu; Jia, Haiqiang; Wang, Wenxin; Chen, Hong

    2018-05-01

    Rectifying characteristics induced by the polarization fields are achieved in the GaN/graded-AlxGa1‑xN/GaN double heterojunction structure (DHS). By grading AlxGa1‑xN from x  =  0.4(0.3) to 0.1, the DHS displays a better conductivity for smaller reverse bias than for forward bias voltages (reverse rectifying behavior) which is opposite to p–n junction rectifying characteristics. The mechanism of reverse rectifying behavior is illustrated via calculating the energy band structures of the samples. The band gap narrowing caused by decreasing Al composition could compensate the for the band tilt due to the polarization effect in AlxGa1‑xN barriers, thus lowering the barrier height for electron transport from top to bottom. The reverse rectifying behavior could be enhanced by increasing the Al content and the thickness of the multi-layer graded AlxGa1‑xN barriers. This work gives a better understanding of the mechanism of carrier transport in a DHS and makes it possible to realize novel GaN-based heterojunction transistors.

  18. Computer-aided field editing in DHS: the Turkey experiment.

    PubMed

    1995-01-01

    A study comparing field editing using a Notebook computer, computer-aided field editing (CAFE), with that done manually in the standard manner, during the 1993 Demographic and Health Survey (DHS) in Turkey, demonstrated that there was less missing data and a lower mean number of errors for teams using CAFE. 6 of 13 teams used CAFE in the Turkey experiment; the computers were equipped with Integrated System for Survey Analysis (ISSA) software for editing the DHS questionnaires. The CAFE teams completed 2466 out of 8619 household questionnaires and 1886 out of 6649 individual questionnaires. The CAFE team editor entered data into the computer and marked any detected errors on the questionnaire; the errors were then corrected by the editor, in the field, based on other responses in the questionnaire, or on corrections made by the interviewer to which the questionnaire was returned. Errors in questionnaires edited manually are not identified until they are sent to the survey office for data processing, when it is too late to ask for clarification from respondents. There was one area where the error rate was higher for CAFE teams; the CAFE editors paid less attention to errors presented as warnings only.

  19. Similarity Evaluation of Different Origins and Species of Dendrobiums by GC-MS and FTIR Analysis of Polysaccharides

    PubMed Central

    Chen, Nai-Dong; Chen, Nai-Fu; Li, Jun; Cao, Cai-Yun; Wang, Jin-Mei; Huang, He-Ping

    2015-01-01

    GC-MS method combined with FTIR techniques by the analysis of polysaccharide was applied to evaluate the similarity between wild (W) and tissue-cultured (TC) Dendrobium huoshanense (DHS), Dendrobium officinale (DO), and Dendrobium moniliforme (DM) as well as 3 wild Dendrobium spp.: Dendrobium henanense (DHN), Dendrobium loddigesii (DL), and Dendrobium crepidatum (DC). Eight monosaccharides involving xylose, arabinose, rhamnose, glucose, mannose, fructose, galactose, and galacturonic acid were identified in the polysaccharide from each Dendrobium sample while the contents of the monosugars varied remarkably across origins and species. Further similarity evaluation based on GC-MS data showed that the r cor values of different origins of DHS, DO, and DM were 0.831, 0.865, and 0.884, respectively, while the r cor values ranged from 0.475 to 0.837 across species. FTIR files of the polysaccharides revealed that the similarity coefficients between W and TC-DHS, DO, and DM were 88.7%, 86.8%, and 88.5%, respectively, in contrast to the similarity coefficients varying from 57.4% to 82.6% across species. These results suggested that the structures of polysaccharides between different origins of the investigated Dendrobiums might be higher than what we had supposed. PMID:26539215

  20. Is there any place for the variable angle proximal femoral plate? A case matched cohort study against the Dynamic Hip Screw system.

    PubMed

    Tucker, A; Diamond, O; McDonald, S; Johnston, A; Neil, M; Kealey, D; Archbold, P

    2016-10-01

    The Variable angle Martin Plate (MP) is designed to offer patient-specific adaption for the treatment of intertrochanteric hip fractures. Its proposed benefits include optimization of lag screw placement, plate shaft congruence and reduced risk of failure. Often its use has been criticized as representing a poor reduction of the fracture. The purpose of this study was to assess for a poorer quality of reduction, and compare functional outcomes and mortality, using a MP to that of a fixed angle Dynamic Hip Screw (DHS) in a matched cohort of patients. A retrospective review of a prospective fracture database system was undertaken between 1st January 2004 to 31st December 2013. MP patients were matched to a cohort of DHS patients. Outcomes measure were a quality of procedure score(QPS), 1-year mortality rates, reoperation rates, and Barthel Index functional outcome. Minimum follow up was 12 months. A total of 77 Martin Plate patients were identified and case matched. The mean pre- and post-op Neck Shaft Angle (NSA) in the MPs was significantly different (132.97±7.78 Vs 126±8.62; p<0.0001). Conversely, the mean pre op DHS NSA and the mean post op NSA was not (p=0.397). Mean Tip-Apex Distance (TAD) was significantly different between groups; MP mean 26.51±9.09mm vs DHS 23.50±8.14mm (p=0.023). The QPS consisted of 4 variables. A significant inverse relationship between QPS and the incidence of construct related complications exists. TAD>25mm, and a change in AP NSA of >5°conveyed the greatest risk of complications. No difference occurred in complications, nor 12-month mortality. No statistical difference was found in the quality of reduction between MP and DHS in this group of matched patients. QPS demonstrated a significant inverse correlation with implant-related complications. No significant difference was noted in the incidence of complications, Barthel Index functional scores, or 12-month mortality between implants. A rationale exists regarding the use of MPs, particularly in patients with varus NSA. However, planning and adequate reduction are essential regardless of implant choice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Multi-temporal Scale Analysis of Environmental Control on Net Ecosystem Exchange of CO2 in Forest Ecosystems

    NASA Astrophysics Data System (ADS)

    Zhang, Mi; Yu, Guirui; Zhuang, Jie; Gentry, Randy; Koirala, Shesh; Zhang, Leiming; Sun, Xiaomin; Han, Shijie; Yan, Junhua

    2013-04-01

    Multi-temporal scale analysis of environmental control on forest ecosystem carbon budget is a basis for understanding the responses and adaptation of forest carbon cycle to climate change. In this study, we chose two typical forest ecosystems, Changbaishan temperate mixed forest (CBS) in northeastern China and Dinghushan subtropical evergreen broad-leaved forest (DHS) in southern China to identify the changes in environmental control on net ecosystem exchange of carbon dioxide (NEE) with the temporal scales. The analysis was made based on the flux and routine meteorological data measured during the period from 2005 to 2008. These time series data were analyzed using wavelet and cross wavelet transform. The results showed that NEE had significant daily and annual periodic variation in the two types of forest ecosystem. NEE at CBS and DHS showed semi-annual (176 days) and seasonal (88-104 days) periodic variations, respectively. Photosynthetically active radiation (PAR), vapor pressure deficient (VPD), air temperature (Ta), soil temperature (Ts, at 5-cm depth) controlled daily variation of NEE as indicated by the significant high common power of cross wavelet transform spectrums between NEE and these factors. Similarly, Ta, VPD, and precipitation (P) controlled annual variation of NEE at CBS. However, Ta, PAR, and soil water content (SWC, at 5-cm depth) dominated the annual variation of NEE at DHS. An anti-phase between NEE and PAR at daily scale in the two forest ecosystems demonstrated an agreement of the variation of NEE with PAR, with rising sunlight corresponding with increased net carbon uptake. At annual scale, phase angles between NEE and Ta and between NEE and P were -170° and 176°, respectively at CBS. At DHS, phase angle between NEE and VPD was smallest at annual scale. The results indicated that the peak of net carbon uptake seasonal variation and the peaks of P and Ta seasonal variations occurred at the same month at CBS. But, at DHS, seasonal variation of net carbon uptake was in agreement with that of VPD at annual scale. This study showed that wavelet analysis was an effective approach to identifying the temporal pattern of environmental control on carbon exchange between ecosystem and the atmosphere.

  2. Quantifying effectiveness in emergency management.

    PubMed

    Weaver, John Michael

    2014-01-01

    This study looked at the relationship between the Departments of Defense (DOD) and Homeland Security (DHS). Moreover, it reviewed the interface between their two subordinate organizations (Northern Command under DOD and the Federal Emergency Management Agency under DHS) with primacy over domestic disasters. Understanding the importance of intergovernmental relations (IGRs), the article dissected the interrelatedness of these organizations regarding hurricanes and the subsequent involvement of federal preparation and response efforts. The informal networked relationships were evaluated using regression analysis focusing on secondary sources of data and several variables. The vitality of collaborative networks is grounded in literature and has been espoused by Waugh and Streib in the world of emergency management; this study expanded on their premise.

  3. M sub shell X-ray emission cross section measurements for Pt, Au, Hg, Pb, Th and U at 8 and 10 keV synchrotron photons

    NASA Astrophysics Data System (ADS)

    Kaur, Gurpreet; Gupta, Sheenu; Tiwari, M. K.; Mittal, Raj

    2014-02-01

    M sub shell X-ray emission cross sections of Pt, Au, Hg, Pb, Th and U at 8 and 10 keV photon energies have been determined with linearly polarized photon beam from Indus-2 synchrotron source. The measured cross sections have been reported for the first time and were used to check the available theoretical Dirac-Hartree-Slater (DHS) and Dirac-Fock (DF) values reported in literature and also the presently derived Non Relativistic Hartree-Slater (NRHS), DF and DHS values for Mξ, Mδ, Mα, Mβ, Mγ, Mm1 and Mm2 group of X-rays.

  4. Characteristics of DO, organic matter, and ammonium profile for practical-scale DHS reactor under various organic load and temperature conditions.

    PubMed

    Nomoto, Naoki; Ali, Muntjeer; Jayaswal, Komal; Iguchi, Akinori; Hatamoto, Masashi; Okubo, Tsutomu; Takahashi, Masanobu; Kubota, Kengo; Tagawa, Tadashi; Uemura, Shigeki; Yamaguchi, Takashi; Harada, Hideki

    2018-04-01

    Profile analysis of the down-flow hanging sponge (DHS) reactor was conducted under various temperature and organic load conditions to understand the organic removal and nitrification process for sewage treatment. Under high organic load conditions (3.21-7.89 kg-COD m -3  day -1 ), dissolved oxygen (DO) on the upper layer of the reactor was affected by organic matter concentration and water temperature, and sometimes reaches around zero. Almost half of the COD Cr was removed by the first layer, which could be attributed to the adsorption of organic matter on sponge media. After the first layer, organic removal proceeded along the first-order reaction equation from the second to the fourth layers. The ammoniacal nitrogen removal ratio decreased under high organic matter concentration (above 100 mg L -1 ) and low DO (less than 1 mg L -1 ) condition. Ammoniacal nitrogen removal proceeded via a zero-order reaction equation along the reactor height. In addition, the profile results of DO, COD Cr , and NH 3 -N were different in the horizontal direction. Thus, it is thought the concentration of these items and microbial activities were not in a uniform state even in the same sponge layer of the DHS reactor.

  5. Female Genital Mutilation in Sierra Leone: Forms, Reliability of Reported Status, and Accuracy of Related Demographic and Health Survey Questions

    PubMed Central

    Grant, Donald S.; Berggren, Vanja

    2013-01-01

    Objective. To determine forms of female genital mutilation (FGM), assess consistency between self-reported and observed FGM status, and assess the accuracy of Demographic and Health Surveys (DHS) FGM questions in Sierra Leone. Methods. This cross-sectional study, conducted between October 2010 and April 2012, enrolled 558 females aged 12–47 from eleven antenatal clinics in northeast Sierra Leone. Data on demography, FGM status, and self-reported anatomical descriptions were collected. Genital inspection confirmed the occurrence and extent of cutting. Results. All participants reported FGM status; 4 refused genital inspection. Using the WHO classification of FGM, 31.7% had type Ib; 64.1% type IIb; and 4.2% type IIc. There was a high level of agreement between reported and observed FGM prevalence (81.2% and 81.4%, resp.). There was no correlation between DHS FGM responses and anatomic extent of cutting, as 2.7% reported pricking; 87.1% flesh removal; and 1.1% that genitalia was sewn closed. Conclusion. Types I and II are the main forms of FGM, with labia majora alterations in almost 5% of cases. Self-reports on FGM status could serve as a proxy measurement for FGM prevalence but not for FGM type. The DHS FGM questions are inaccurate for determining cutting extent. PMID:24204384

  6. Chromosomal position effects in chicken lysozyme gene transgenic mice are correlated with suppression of DNase I hypersensitive site formation.

    PubMed Central

    Huber, M C; Bosch, F X; Sippel, A E; Bonifer, C

    1994-01-01

    The complete chicken lysozyme gene locus is expressed copy number dependently and at a high level in macrophages of transgenic mice. Gene expression independent of genomic position can only be achieved by the concerted action of all cis regulatory elements located on the lysozyme gene domain. Position independency of expression is lost if one essential cis regulatory region is deleted. Here we compared the DNase I hypersensitive site (DHS) pattern formed on the chromatin of position independently and position dependently expressed transgenes in order to assess the influence of deletions within the gene domain on active chromatin formation. We demonstrate, that in position independently expressed transgene all DHSs are formed with the authentic relative frequency on all genes. This is not the case for position dependently expressed transgenes. Our results show that the formation of a DHS during cellular differentiation does not occur autonomously. In case essential regulatory elements of the chicken lysozyme gene domain are lacking, the efficiency of DHS formation on remaining cis regulatory elements during myeloid differentiation is reduced and influenced by the chromosomal position. Hence, no individual regulatory element on the lysozyme domain is capable of organizing the chromatin structure of the whole locus in a dominant fashion. Images PMID:7937145

  7. Effectiveness of treatment of transtrochanteric fractures with Dynamic Hip Screws using minimally invasive access☆

    PubMed Central

    de Abreu, Eduardo Lima; Sena, Caroline Brum; Saldanha Rodrigues Filho, Sergio Antonio

    2016-01-01

    Objective To analyze the short-term results from treating unstable intertrochanteric fractures with Dynamic Hip Screws (DHS), using a minimally invasive route, focusing on the functional aspects and complication and mortality rates of the method. Methods This was a prospective longitudinal study on 140 patients who underwent fixation of transtrochanteric fractures with the DHS system with a lateral minimally invasive access in the hip, between January and December 2013. The patients were evaluated pre and postoperatively (after six months of follow-up) by means of the Parker and Palmer mobility score. Women comprised 65.7% of the sample, and 54.3% of the fractures were on the right side. The patients’ mean age was 80 years, ranging from 60 to 93 years. Results We observed an overall decrease in the mobility score and an increase in the degree of dependence over the short term. However, we encountered only two deaths in the study sample and there were no cases of infection or nonunion. Conclusion Despite the efficacy of the treatment with DHS, with high rates of fracture consolidation and a low mortality rate, we noted that the patients still showed significant functional limitation at the follow-up six months after the operation. PMID:27069880

  8. Defining microbial community composition and seasonal variation in a sewage treatment plant in India using a down-flow hanging sponge reactor.

    PubMed

    Nomoto, Naoki; Hatamoto, Masashi; Hirakata, Yuga; Ali, Muntjeer; Jayaswal, Komal; Iguchi, Akinori; Okubo, Tsutomu; Takahashi, Masanobu; Kubota, Kengo; Tagawa, Tadashi; Uemura, Shigeki; Yamaguchi, Takashi; Harada, Hideki

    2018-05-01

    The characteristics of the microbial community in a practical-scale down-flow hanging sponge (DHS) reactor, high in organic matter and sulfate ion concentration, and the seasonal variation of the microbial community composition were investigated. Microorganisms related to sulfur oxidation and reduction (2-27%), as well as Leucobacter (7.50%), were abundant in the reactor. Anaerobic bacteria (27-38% in the first layer) were also in abundance and were found to contribute to the removal of organic matter from the sewage in the reactor. By comparing the Simpson index, the abundance-based coverage estimator (ACE) index, and the species composition of the microbial community across seasons (summer/dry, summer/rainy, autumn/dry, and winter/dry), the microbial community was found to change in composition only during the winter season. In addition to the estimation of seasonal variation, the difference in the microbial community composition along the axes of the DHS reactor was investigated for the first time. Although the abundance of each bacterial species differed along both axes of the reactor, the change of the community composition in the reactor was found to be greater along the vertical axis than the horizontal axis of the DHS reactor.

  9. Does video gaming affect orthopaedic skills acquisition? A prospective cohort-study.

    PubMed

    Khatri, Chetan; Sugand, Kapil; Anjum, Sharika; Vivekanantham, Sayinthen; Akhtar, Kash; Gupte, Chinmay

    2014-01-01

    Previous studies have suggested that there is a positive correlation between the extent of video gaming and efficiency of surgical skill acquisition on laparoscopic and endovascular surgical simulators amongst trainees. However, the link between video gaming and orthopaedic trauma simulation remains unexamined, in particular dynamic hip screw (DHS) stimulation. To assess effect of prior video gaming experience on virtual-reality (VR) haptic-enabled DHS simulator performance. 38 medical students, naïve to VR surgical simulation, were recruited and stratified relative to their video gaming exposure. Group 1 (n = 19, video-gamers) were defined as those who play more than one hour per day in the last calendar year. Group 2 (n = 19, non-gamers) were defined as those who play video games less than one hour per calendar year. Both cohorts performed five attempts on completing a VR DHS procedure and repeated the task after a week. Metrics assessed included time taken for task, simulated flouroscopy time and screw position. Median and Bonett-Price 95% confidence intervals were calculated for seven real-time objective performance metrics. Data was confirmed as non-parametric by the Kolmogorov-Smirnov test. Analysis was performed using the Mann-Whitney U test for independent data whilst the Wilcoxon signed ranked test was used for paired data. A result was deemed significant when a two-tailed p-value was less than 0.05. All 38 subjects completed the study. The groups were not significantly different at baseline. After ten attempts, there was no difference between Group 1 and Group 2 in any of the metrics tested. These included time taken for task, simulated fluoroscopy time, number of retries, tip-apex distance, percentage cut-out and global score. Contrary to previous literature findings, there was no correlation between video gaming experience and gaining competency on a VR DHS simulator.

  10. Dynamic hip system blade versus cannulated compression screw for the treatment of femoral neck fractures: A retrospective study.

    PubMed

    Chen, Chao; Yu, Li; Tang, Xin; Liu, Mo-Zhen; Sun, Li-Zhong; Liu, Changjian; Zhang, Zhen; Li, Chang-Zhou

    2017-10-01

    The aim of this study was to compare clinical outcomes of patients with femoral neck fractures treated with the dynamic hip system blade (DHS-BLADE) or cannulated compression screws. Eighty-six patients with femoral neck fractures were treated by closed reduction internal fixation with a DHS-BLADE (n = 42; 18 males and 24 females; mean age: 56.3 years (37-87)) or cannulated compression screws (n = 44; 20 males and 24 females; mean age: 53.8 years (26-83)) between March 2011 and August 2013. The groups were compared with Harris hip score, operation time, surgical blood loss, incision size, hospital stay, and related complications. The average follow-up time was 27 months (range, 24-36 months). There was no significant difference for the operation time, incision size, hospital stay, and Harris hip score between the groups. Also, no statistically significant differences in the rates of nonunion (4.5% vs. 0) and avascular necrosis of the femoral head (9.1% vs. 7.1%) were observed. However, the screw group experienced significantly less surgical blood loss (32.4 ± 24.7 ml) than the blade group (87.2 ± 46.6 ml; P = 0.041). The incidence of femoral neck shortening above 10 mm in the screw group was significantly higher than that in the blade group (15.9% vs. 2.4%, P = 0.031). The blade group had a significantly lower incidence of screw migration than the screw group (4.8% vs. 22.7%, P = 0.016). The DHS-BLADE and cannulated compression screws might be equally effective in terms of postoperative fracture union. However, the DHS-BLADE has advantages over cannulated compression screws for preventing femoral neck shortening, screw migration, and cut-out. Level III, Therapeutic study. Copyright © 2017 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.

  11. Plasma metabolic profiling on postoperative colorectal cancer patients with different traditional Chinese medicine syndromes.

    PubMed

    Hu, Xue-Qing; Wei, Bin; Song, Ya-Nan; Ji, Qing; Li, Qi; Luo, Yun-Quan; Wang, Wen-Hai; Su, Shi-Bing

    2018-02-01

    This study aims to investigate the metabolic profiles of postoperative colorectal cancer (PCRC) patients with different traditional Chinese medicine (TCM) syndromes and to discuss the metabolic mechanism under PCRC progression and TCM syndrome classification. Fifty healthy controls (HC) and 70 PCRC patients, including 10 Dampness and heat syndrome (DHS), 33 Spleen deficiency syndrome (SDS), 19 Liver and kidney Yin deficiency syndrome (LKYDS) and 8 with non-TCM syndrome (NS) were enrolled. Plasma metabolic profiles were detected by Gas chromatography-mass spectrometry (GC-MS) and analyzed by principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA). Furthermore, pathway enrichment was analyzed based on KEGG and DAVID databases and metabolic network was constructed via metaboanalyst and cytoscape. The top-3 metabolites with higher abundance in PCRC compared with HC were terephthalic acid (165.417-fold), ornithine (24.484-fold) and aminomalonic acid (21.346-fold). And the cholesterol (0.588-fold) level was decreased in PCRC. l-Alanine, 1, 2-ethanediamine, urea, glycerol, glycine, aminomalonic acid, creatinine and palmitic acid were specifically altered in the DHS, while d-tryptophan was exclusively changed in SDS, and l-proline, 1, 2, 3-propanetricarboxylic acid, d-galactose and 2-indolecarboxylic acids in LKYDS. The plasma metabolic profiles were perturbed in PCRC patients. Increased levels of terephthalic acid might indicate high risk of relapse and elevated ornithine may contribute to the post-operational recovery or may raise the susceptibility to PCRC recurrence. The metabolic profiles of DHS, SDS, LKYDS and NS were almost separately clustered, indicating the possibility of explaining TCM syndromes classification using metabolomics. Furthermore, creatinine and aminomalonic acid alternation might correlate with the formation of DHS, while d-tryptophan may associate with SDS and d-galactose and 1, 2, 3-propanetricarboxylic acid may relate to LKYDS. As numbers of patients in each TCM syndrome are small, further study is needed to verify those results. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Insulin Resistance and Risk Factors for Cardiovascular Disease in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

    PubMed Central

    Oeffinger, Kevin C.; Adams-Huet, Beverley; Victor, Ronald G.; Church, Timothy S.; Snell, Peter G.; Dunn, Andrea L.; Eshelman-Kent, Debra A.; Ross, Robert; Janiszewski, Peter M.; Turoff, Alicia J.; Brooks, Sandra; Vega, Gloria Lena

    2009-01-01

    Purpose To determine the prevalence of insulin resistance and other risk factors for cardiovascular disease (CVD) in young adult survivors of childhood acute lymphoblastic leukemia (ALL). Patients and Methods In this cross-sectional evaluation of 118 survivors of childhood ALL (median age, 23.0 years; range, 18 to 37 years), insulin resistance was estimated using the homeostasis model for assessment of insulin resistance (HOMA-IR). Sex-specific comparisons were made with a cohort of 30- to 37-year-old individuals from the same region participating in the Dallas Heart Study (DHS, N = 782). ALL survivors were stratified by treatment with and without cranial radiotherapy (CRT). Results Female ALL survivors had a significantly higher HOMA-IR (CRT, mean 4.6, 95% CI, 3.6 to 5.7; no CRT, mean 3.3, 95% CI, 2.8 to 3.8) in comparison with DHS women (mean 2.4, 95% CI, 2.2 to 2.7). Eighty percent of women treated with CRT had at least three of six CVD risk factors, and they were significantly more likely to have three or more risk factors compared with DHS women (odds ratio [OR], 5.96; 95% CI, 2.15 to 16.47). Male ALL survivors had a significantly higher HOMA-IR (CRT, mean 4.0, 95% CI, 2.8 to 5.6; no CRT, mean 3.4, 95% CI, 2.9 to 3.9) in comparison with DHS men (mean 2.3, 95% CI, 2.1 to 2.6), but were not more likely to have multiple CVD risk factors. Conclusion ALL survivors had an increased prevalence of insulin resistance in comparison with a cohort of older individuals from the same community. Importantly, women treated with CRT seem to have an increased prevalence of multiple CVD risk factors, warranting close monitoring and risk-reducing strategies. PMID:19564534

  13. The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase.

    PubMed

    Specht, Sabine; Sarite, Salem Ramadan; Hauber, Ilona; Hauber, Joachim; Görbig, Ulf F; Meier, Chris; Bevec, Dorian; Hoerauf, Achim; Kaiser, Annette

    2008-05-01

    Malaria is still a major cause of death in the tropics. There is an urgent need for new anti-malarial drugs because drug-resistant plasmodia frequently occur. Over recent years, we elucidated the biosynthesis of hypusine, a novel amino acid contained in eukaryotic initiation factor 5A (eIF-5A) in Plasmodium. Hypusine biosynthesis involves catalysis of deoxyhypusine synthase (DHS) in the first step of post-translational modification. In a screen for new inhibitors of purified plasmodium DHS, CNI-1493, a novel selective pro-inflammatory cytokine inhibitor used in clinical phase II for the treatment of Crohn's disease, inhibited the enzyme of the parasite 3-fold at a concentration of 2 microM. In vitro experiments with 200 microM CNI-1493 in Plasmodium-infected erythrocytes, which lack nuclei and DHS protein, showed a parasite clearance within 2 days. This can presumably be attributed to an anti-proliferating effect because of the inhibition of DHS by the parasite. The determined IC50 of CNI-1493 was 135.79 microM after 72 h. In vivo application of this substance in Plasmodium berghei ANKA-infected C57BL/6 mice significantly reduced parasitemia after dosage of 1 mg/kg or 4 mg/kg/body weight and prevented death of mice with cerebral malaria. This effect was paralleled by a decrease in serum TNF levels of the mice. We suggest that the new mechanism of CNI-1493 is caused by a decrease in modified eIF-5A biosynthesis with a downstream effect on the TNF synthesis of the host. From the current data, we consider CNI-1493 to be a promising drug for anti-malarial therapy because of its combined action, i.e., the decrease in eIF-5A biosynthesis of the parasite and host cell TNF biosynthesis.

  14. Estimating Contraceptive Prevalence Using Logistics Data for Short-Acting Methods: Analysis Across 30 Countries.

    PubMed

    Cunningham, Marc; Bock, Ariella; Brown, Niquelle; Sacher, Suzy; Hatch, Benjamin; Inglis, Andrew; Aronovich, Dana

    2015-09-01

    Contraceptive prevalence rate (CPR) is a vital indicator used by country governments, international donors, and other stakeholders for measuring progress in family planning programs against country targets and global initiatives as well as for estimating health outcomes. Because of the need for more frequent CPR estimates than population-based surveys currently provide, alternative approaches for estimating CPRs are being explored, including using contraceptive logistics data. Using data from the Demographic and Health Surveys (DHS) in 30 countries, population data from the United States Census Bureau International Database, and logistics data from the Procurement Planning and Monitoring Report (PPMR) and the Pipeline Monitoring and Procurement Planning System (PipeLine), we developed and evaluated 3 models to generate country-level, public-sector contraceptive prevalence estimates for injectable contraceptives, oral contraceptives, and male condoms. Models included: direct estimation through existing couple-years of protection (CYP) conversion factors, bivariate linear regression, and multivariate linear regression. Model evaluation consisted of comparing the referent DHS prevalence rates for each short-acting method with the model-generated prevalence rate using multiple metrics, including mean absolute error and proportion of countries where the modeled prevalence rate for each method was within 1, 2, or 5 percentage points of the DHS referent value. For the methods studied, family planning use estimates from public-sector logistics data were correlated with those from the DHS, validating the quality and accuracy of current public-sector logistics data. Logistics data for oral and injectable contraceptives were significantly associated (P<.05) with the referent DHS values for both bivariate and multivariate models. For condoms, however, that association was only significant for the bivariate model. With the exception of the CYP-based model for condoms, models were able to estimate public-sector prevalence rates for each short-acting method to within 2 percentage points in at least 85% of countries. Public-sector contraceptive logistics data are strongly correlated with public-sector prevalence rates for short-acting methods, demonstrating the quality of current logistics data and their ability to provide relatively accurate prevalence estimates. The models provide a starting point for generating interim estimates of contraceptive use when timely survey data are unavailable. All models except the condoms CYP model performed well; the regression models were most accurate but the CYP model offers the simplest calculation method. Future work extending the research to other modern methods, relating subnational logistics data with prevalence rates, and tracking that relationship over time is needed. © Cunningham et al.

  15. Estimating Contraceptive Prevalence Using Logistics Data for Short-Acting Methods: Analysis Across 30 Countries

    PubMed Central

    Cunningham, Marc; Brown, Niquelle; Sacher, Suzy; Hatch, Benjamin; Inglis, Andrew; Aronovich, Dana

    2015-01-01

    Background: Contraceptive prevalence rate (CPR) is a vital indicator used by country governments, international donors, and other stakeholders for measuring progress in family planning programs against country targets and global initiatives as well as for estimating health outcomes. Because of the need for more frequent CPR estimates than population-based surveys currently provide, alternative approaches for estimating CPRs are being explored, including using contraceptive logistics data. Methods: Using data from the Demographic and Health Surveys (DHS) in 30 countries, population data from the United States Census Bureau International Database, and logistics data from the Procurement Planning and Monitoring Report (PPMR) and the Pipeline Monitoring and Procurement Planning System (PipeLine), we developed and evaluated 3 models to generate country-level, public-sector contraceptive prevalence estimates for injectable contraceptives, oral contraceptives, and male condoms. Models included: direct estimation through existing couple-years of protection (CYP) conversion factors, bivariate linear regression, and multivariate linear regression. Model evaluation consisted of comparing the referent DHS prevalence rates for each short-acting method with the model-generated prevalence rate using multiple metrics, including mean absolute error and proportion of countries where the modeled prevalence rate for each method was within 1, 2, or 5 percentage points of the DHS referent value. Results: For the methods studied, family planning use estimates from public-sector logistics data were correlated with those from the DHS, validating the quality and accuracy of current public-sector logistics data. Logistics data for oral and injectable contraceptives were significantly associated (P<.05) with the referent DHS values for both bivariate and multivariate models. For condoms, however, that association was only significant for the bivariate model. With the exception of the CYP-based model for condoms, models were able to estimate public-sector prevalence rates for each short-acting method to within 2 percentage points in at least 85% of countries. Conclusions: Public-sector contraceptive logistics data are strongly correlated with public-sector prevalence rates for short-acting methods, demonstrating the quality of current logistics data and their ability to provide relatively accurate prevalence estimates. The models provide a starting point for generating interim estimates of contraceptive use when timely survey data are unavailable. All models except the condoms CYP model performed well; the regression models were most accurate but the CYP model offers the simplest calculation method. Future work extending the research to other modern methods, relating subnational logistics data with prevalence rates, and tracking that relationship over time is needed. PMID:26374805

  16. 76 FR 54244 - Telecommunications Service Priority System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Homeland Security (DHS), National Protection and Programs Directorate (NPPD), Office of Cybersecurity and... Programs Directorate, Office of Cybersecurity and Communications, National Communications System. Title...

  17. Measurement of fatigue following 18 msw dry chamber dives breathing air or enriched air nitrox.

    PubMed

    Harris, R J D; Doolette, D J; Wilkinson, D C; Williams, D J

    2003-01-01

    Many divers report less fatigue following diving breathing oxygen rich N2-O2 mixtures compared with breathing air. In this double blinded, randomized controlled study 11 divers breathed either air or Enriched Air Nitrox 36% (oxygen 36%, nitrogen 64%) during an 18 msw (281 kPa(a)) dry chamber dive for a bottom time of 40 minutes. Two periods of exercise were performed during the dive. Divers were assessed before and after each dive using the Multidimensional Fatigue Inventory-20, a visual analogue scale, Digit Span Tests, Stroop Tests, and Divers Health Survey (DHS). Diving to 18m produced no measurable difference in fatigue, attention levels, ability to concentrate or DHS scores, following dives using either breathing gas.

  18. 75 FR 47699 - Employment Authorization for Dependents of Foreign Officials

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ...The Department of Homeland Security (DHS) is amending its regulations governing the employment authorization for dependents of foreign officials classified as A-1, A-2, G-1, G-3, and G-4 nonimmigrants. This rule expands the list of dependents who are eligible for employment authorization from spouses, children, and qualifying sons and daughters of A or G foreign officials to include any other immediate family member who falls within a category of aliens designated by the Department of State as qualifying. This change to DHS regulations provides the Department of State with greater flexibility when entering into bilateral agreements and arrangements with other countries that would extend employment authorization to immediate family members who are recognized as such by the Department of State.

  19. Comparison of conventional therapies for dentin hypersensitivity versus medical hypnosis.

    PubMed

    Eitner, Stephan; Bittner, Christian; Wichmann, Manfred; Nickenig, Hans-Joachim; Sokol, Biljana

    2010-10-01

    This study compared the efficacy of conventional treatments for dentin hypersensitivity (DHS) and hypnotherapy. During a 1-month period at an urban practice in a service area of approximately 22,000 inhabitants, all patients were examined. A total of 102 individuals were included in the evaluation. Values of 186 teeth were analyzed. The comparison of the different treatment methods (desensitizer, fluoridation, and hypnotherapy) did not show significant differences in success rates. However, a noticeable difference was observed in terms of onset and duration of effect. For both desensitizer and hypnotherapy treatments, onset of effect was very rapid. Compared to the other methods studied, hypnotherapy effects had the longest duration. In conclusion, hypnotherapy was as effective as other methods in the treatment of DHS.

  20. Psychometric Properties of Newly Translated Spanish Life Events Inventory and Daily Hassles Scale.

    PubMed

    Hannan, Jean; Youngblut, JoAnne M; Brooten, Dorothy; Bazzani, Dianne; Romero, Norma R; Chavez, Blanca; Picanes, Joann

    2015-01-01

    Measuring stress in Hispanic Americans, the fastest growing U.S. minority, is problematic. The Life Events Inventory (LEI) and the Daily Hassles Scale (DHS), widely used stress instruments, are not available in Spanish. To test the psychometric properties of the translated Spanish versions of the LEI and DHS. A convenience sample of 63 Hispanic women completed both instruments in Spanish and English 2 weeks apart. Internal consistency reliability and stability were strong for both instruments (.85-.97). Reliability and validity evidence for the translated Spanish versions were strong and similar to the English version. Psychometric findings suggest that the newly translated Spanish versions are good representations of the English versions and that these newly translated instruments are ready for use.

  1. Bolivia 1998: results from the Demographic and Health Survey.

    PubMed

    2000-09-01

    This document presents the results of the Bolivia Demographic and Health Survey (DHS), or Encuesta Nacional de Demografia y Salud 1998, conducted by the Instituto Nacional de Estadistica, La Paz, Bolivia, within the framework of the DHS Program of Macro International. Data were collected from 12,109 households and complete interviews were conducted with 11,187 women aged 15-49. A male survey was also conducted, which collected data from 3780 men aged 15-64. The information collected include the following: 1) general characteristics of the population, 2) fertility, 3) fertility preferences, 4) current contraceptive use, 5) contraception, 6) marital and contraceptive status, 7) postpartum variables, 8) infant mortality, 9) health: disease prevention and treatment, and 10) nutritional status: anthropometric measures.

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Karpius, Peter Joseph; Myers, Steven Charles

    This presentation is a part of the DHS LSS spectroscopy course and provides an overview of the following concepts: detector system components, intrinsic and absolute efficiency, resolution and linearity, and operational issues and limits.

  3. Explosive Detection in Aviation Applications Using CT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martz, H E; Crawford, C R

    2011-02-15

    CT scanners are deployed world-wide to detect explosives in checked and carry-on baggage. Though very similar to single- and dual-energy multi-slice CT scanners used today in medical imaging, some recently developed explosives detection scanners employ multiple sources and detector arrays to eliminate mechanical rotation of a gantry, photon counting detectors for spectral imaging, and limited number of views to reduce cost. For each bag scanned, the resulting reconstructed images are first processed by automated threat recognition algorithms to screen for explosives and other threats. Human operators review the images only when these automated algorithms report the presence of possible threats.more » The US Department of Homeland Security (DHS) has requirements for future scanners that include dealing with a larger number of threats, higher probability of detection, lower false alarm rates and lower operating costs. One tactic that DHS is pursuing to achieve these requirements is to augment the capabilities of the established security vendors with third-party algorithm developers. A third-party in this context refers to academics and companies other than the established vendors. DHS is particularly interested in exploring the model that has been used very successfully by the medical imaging industry, in which university researchers develop algorithms that are eventually deployed in commercial medical imaging equipment. The purpose of this paper is to discuss opportunities for third-parties to develop advanced reconstruction and threat detection algorithms.« less

  4. 78 FR 20684 - Towing Safety Advisory Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... Government. DHS does not discriminate in employment on the basis of race, color, religion, sex, national origin, political affiliation, sexual orientation, gender identity, marital status, disabilities and...

  5. 75 FR 21011 - National Protection and Programs Directorate; Statewide Communication Interoperability Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... Directorate/Cybersecurity and Communications/Office of Emergency Communications, has submitted the following... Homeland Security (DHS), National Protection and Programs Directorate/Cybersecurity and Communications...

  6. 78 FR 71629 - Technical Resource for Incident Prevention (TRIPwire) User Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ...), Office of Infrastructure Protection (IP), Protective Security Coordination Division (PSCD), Office for... INFORMATION CONTACT: William Cooper, DHS/NPPD/IP/PSCD/OBP, [email protected] . SUPPLEMENTARY...

  7. Report for the NGFA-5 project.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jaing, C; Jackson, P; Thissen, J

    The objective of this project is to provide DHS a comprehensive evaluation of the current genomic technologies including genotyping, TaqMan PCR, multiple locus variable tandem repeat analysis (MLVA), microarray and high-throughput DNA sequencing in the analysis of biothreat agents from complex environmental samples. To effectively compare the sensitivity and specificity of the different genomic technologies, we used SNP TaqMan PCR, MLVA, microarray and high-throughput illumine and 454 sequencing to test various strains from B. anthracis, B. thuringiensis, BioWatch aerosol filter extracts or soil samples that were spiked with B. anthracis, and samples that were previously collected during DHS and EPAmore » environmental release exercises that were known to contain B. thuringiensis spores. The results of all the samples against the various assays are discussed in this report.« less

  8. A Report on the Activities, Publications, and Pending Research of DHS/DOD Sponsored Post-doctoral Research Associate at Los Alamos National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stanley, Floyd E.; Tandon, Lav

    Since beginning at Los Alamos National Laboratory in February of 2012, I have been working as a DHS./DNDO Postdoctoral Research Associate under the mentorship of Lav Tandon and Khalil Spencer (NA-22 and mass spectrometry). The focus of my efforts, in addition to pursuing needed training and qualifications, has been the application of various instrumental approaches (e.g. Thermal Ionization Mass Spectrometry; TIMS) to a range of systems of interest in materials characterization and nuclear forensics. Research to be pursued in the coming months shall include the continued use of such approaches to advance current methods for: modified total evaporation, monitoring criticalmore » minor isotope systems, and chronometry. Each of the above points will be discussed.« less

  9. Object tracking based on harmony search: comparative study

    NASA Astrophysics Data System (ADS)

    Gao, Ming-Liang; He, Xiao-Hai; Luo, Dai-Sheng; Yu, Yan-Mei

    2012-10-01

    Visual tracking can be treated as an optimization problem. A new meta-heuristic optimal algorithm, Harmony Search (HS), was first applied to perform visual tracking by Fourie et al. As the authors point out, many subjects are still required in ongoing research. Our work is a continuation of Fourie's study, with four prominent improved variations of HS, namely Improved Harmony Search (IHS), Global-best Harmony Search (GHS), Self-adaptive Harmony Search (SHS) and Differential Harmony Search (DHS) adopted into the tracking system. Their performances are tested and analyzed on multiple challenging video sequences. Experimental results show that IHS is best, with DHS ranking second among the four improved trackers when the iteration number is small. However, the differences between all four reduced gradually, along with the increasing number of iterations.

  10. Long-range Coulomb effect in above-threshold ionization of Ne subject to few-cycle and multicycle laser fields

    NASA Astrophysics Data System (ADS)

    Xu, SongPo; Quan, Wei; Chen, YongJu; Xiao, ZhiLei; Wang, YanLan; Kang, HuiPeng; Hua, LinQiang; Gong, Cheng; Lai, XuanYang; Liu, XiaoJun; Hao, XiaoLei; Hu, ShiLin; Chen, Jing

    2017-06-01

    The long-range Coulomb effect (LRCE) is demonstrated experimentally and theoretically by investigating the pulse duration dependence of low-energy structure (LES) in above-threshold ionization of Ne. It is found experimentally that at 800 nm the LES shows itself as a double-hump structure (DHS) in momentum distribution of singly charged ion for Ne, and moreover, this structure is more prominent for multicycle laser fields than for few-cycle cases. This result can be reproduced and explained qualitatively with a semiclassical model and attributed to the paramount role of LRCE. That is to say, after the laser field vanishes, the electrons decelerate while flying away from the core by the long-range tail of Coulomb potential, which eventually makes DHS less notable.

  11. Experimental validation of alternate integral-formulation method for predicting acoustic radiation based on particle velocity measurements.

    PubMed

    Ni, Zhi; Wu, Sean F

    2010-09-01

    This paper presents experimental validation of an alternate integral-formulation method (AIM) for predicting acoustic radiation from an arbitrary structure based on the particle velocities specified on a hypothetical surface enclosing the target source. Both the normal and tangential components of the particle velocity on this hypothetical surface are measured and taken as the input to AIM codes to predict the acoustic pressures in both exterior and interior regions. The results obtained are compared with the benchmark values measured by microphones at the same locations. To gain some insight into practical applications of AIM, laser Doppler anemometer (LDA) and double hotwire sensor (DHS) are used as measurement devices to collect the particle velocities in the air. Measurement limitations of using LDA and DHS are discussed.

  12. Summarizing my DHS Internship Experience

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roberts, D L

    2006-09-06

    In this paper, the author addresses four main topics: (1) A description of the topic of his internship at the U.S. Department of Homeland Security; (2) A description of his contributions to the project; (3) A discussion of research directions beneficial to the Department of Homeland Security (DHS); and (4) A discussion of the impact the internship experience had on his career aspirations. He feels the first three points can best be addressed using the contents of a paper his mentor, Dr. Tina Eliassi-Rad, and he have published based on their work this summer [Roberts and Eliassi-Rad, 2006]. Sections 2more » - 5 are intended for this purpose and have been excerpted from that paper. He concludes this paper in Section 6 with a discussion of the fourth point.« less

  13. Changing the paradigm: planning for ambulatory care expansion in Los Angeles County using a community-based and evidence-based model.

    PubMed

    Fielding, J E; Lamirault, I; Nolan, B; Bobrowsky, J

    2000-07-01

    In 1998, Los Angeles County's Department of Health Services (DHS) embarked on a planning process to expand ambulatory care services for the county's 2.7 million uninsured and otherwise medically indigent residents. This planning process was novel in two ways. First, it used a quantitative, needs-based approach for resource allocation to ensure an equitable distribution of safety-net ambulatory care services across the county. Second, it used a new community-based planning paradigm that took into consideration the specific needs of each of the county's eight geographic service planning areas. Together, the evidence-based approach to planning and the community-based decision-making will ensure that DHS can more equitably provide for the needs of Los Angeles County's medically indigent residents.

  14. 78 FR 49544 - Great Lakes Pilotage Advisory Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... Homeland Security (DHS) does not discriminate in employment on the basis of race, color, religion, sex, national origin, political affiliation, sexual orientation, gender identity, marital status, disability and...

  15. 78 FR 36790 - Commercial Fishing Safety Advisory Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... Homeland Security (DHS) does not discriminate in employment on the basis of race, color, religion, sex, national origin, political affiliation, sexual orientation, gender identity, marital status, disability and...

  16. 78 FR 16692 - Chemical Facility Anti-Terrorism Standards (CFATS)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... Protection (IP), Infrastructure Security Compliance Division (ISCD) will submit the following Information... submissions of responses. FOR FURTHER INFORMATION CONTACT: CFATS Program Manager, DHS/NPPD/IP/ ISCD, [email protected

  17. 44 CFR 208.12 - Maximum Pay Rate Table.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Physicians. DHS uses the latest Special Salary Rate Table Number 0290 for Medical Officers (Clinical... organizations, e.g., HMOs or medical or engineering professional associations, under the revised definition of...

  18. 5 CFR 9701.231 - Conversion of positions and employees to the DHS classification system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Classification Transitional...

  19. DHS National Technical Nuclear Forensics Program FY 10 Summary Report: Graduate Mentoring Assistance Program (GMAP)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martha R. Finck Ph.D.

    2011-10-01

    This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to the graduate student's formation as a member of the nuclear forensics community. The summary report details the student/mentor experience and future plans after the first summer practicum. This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to themore » graduate student's formation as a member of the nuclear forensics community. This final written report includes information concerning the overall mentoring experience, including benefits (to the lab, the mentors, and the students), challenges, student research contributions, and lab mentor interactions with students home universities. Idaho National Laboratory hosted two DHS Nuclear Forensics graduate Fellows (nuclear engineering) in summer 2011. Two more Fellows (radiochemistry) are expected to conduct research at the INL under this program starting in 2012. An undergraduate Fellow (nuclear engineering) who worked in summer 2011 at the laboratory is keenly interested in applying for the NF Graduate Fellowship this winter with the aim of returning to INL. In summary, this program appears to have great potential for success in supporting graduate level students who pursue careers in nuclear forensics. This relatively specialized field may not have been an obvious choice for some who have already shown talent in the traditional areas of chemistry or nuclear engineering. The active recruiting for this scholarship program for candidates at universities across the U.S. brings needed visibility to this field. Not only does this program offer critical practical training to these students, it brings attention to a very attractive field of work where young professionals are urgently required in order for the future. The effectiveness of retaining such talent remains to be seen and may be primarily controlled by the availability of DOE laboratory research funding in this field in the years to come.« less

  20. 10-Year Coronary Heart Disease Risk Prediction Using Coronary Artery Calcium and Traditional Risk Factors: Derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) With Validation in the HNR (Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study).

    PubMed

    McClelland, Robyn L; Jorgensen, Neal W; Budoff, Matthew; Blaha, Michael J; Post, Wendy S; Kronmal, Richard A; Bild, Diane E; Shea, Steven; Liu, Kiang; Watson, Karol E; Folsom, Aaron R; Khera, Amit; Ayers, Colby; Mahabadi, Amir-Abbas; Lehmann, Nils; Jöckel, Karl-Heinz; Moebus, Susanne; Carr, J Jeffrey; Erbel, Raimund; Burke, Gregory L

    2015-10-13

    Several studies have demonstrated the tremendous potential of using coronary artery calcium (CAC) in addition to traditional risk factors for coronary heart disease (CHD) risk prediction. However, to date, no risk score incorporating CAC has been developed. The goal of this study was to derive and validate a novel risk score to estimate 10-year CHD risk using CAC and traditional risk factors. Algorithm development was conducted in the MESA (Multi-Ethnic Study of Atherosclerosis), a prospective community-based cohort study of 6,814 participants age 45 to 84 years, who were free of clinical heart disease at baseline and followed for 10 years. MESA is sex balanced and included 39% non-Hispanic whites, 12% Chinese Americans, 28% African Americans, and 22% Hispanic Americans. External validation was conducted in the HNR (Heinz Nixdorf Recall Study) and the DHS (Dallas Heart Study). Inclusion of CAC in the MESA risk score offered significant improvements in risk prediction (C-statistic 0.80 vs. 0.75; p < 0.0001). External validation in both the HNR and DHS studies provided evidence of very good discrimination and calibration. Harrell's C-statistic was 0.779 in HNR and 0.816 in DHS. Additionally, the difference in estimated 10-year risk between events and nonevents was approximately 8% to 9%, indicating excellent discrimination. Mean calibration, or calibration-in-the-large, was excellent for both studies, with average predicted 10-year risk within one-half of a percent of the observed event rate. An accurate estimate of 10-year CHD risk can be obtained using traditional risk factors and CAC. The MESA risk score, which is available online on the MESA web site for easy use, can be used to aid clinicians when communicating risk to patients and when determining risk-based treatment strategies. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  1. 49 CFR 15.9 - Restrictions on the disclosure of SSI.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DOT or DHS component or agency. (d) Additional requirements for critical infrastructure information. In the case of information that is both SSI and has been designated as critical infrastructure...

  2. 49 CFR 15.9 - Restrictions on the disclosure of SSI.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DOT or DHS component or agency. (d) Additional requirements for critical infrastructure information. In the case of information that is both SSI and has been designated as critical infrastructure...

  3. 49 CFR 15.9 - Restrictions on the disclosure of SSI.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... DOT or DHS component or agency. (d) Additional requirements for critical infrastructure information. In the case of information that is both SSI and has been designated as critical infrastructure...

  4. 15 CFR 30.73 - Enforcement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... procedures approved by the Attorney General. (b) Department of Homeland Security (DHS). ICE and CBP may enforce the provisions of this part and ICE, as assisted by CBP may conduct investigations under this part. ...

  5. 15 CFR 30.73 - Enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... procedures approved by the Attorney General. (b) Department of Homeland Security (DHS). ICE and CBP may enforce the provisions of this part and ICE, as assisted by CBP may conduct investigations under this part. ...

  6. 15 CFR 30.73 - Enforcement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... procedures approved by the Attorney General. (b) Department of Homeland Security (DHS). ICE and CBP may enforce the provisions of this part and ICE, as assisted by CBP may conduct investigations under this part. ...

  7. 15 CFR 30.73 - Enforcement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... procedures approved by the Attorney General. (b) Department of Homeland Security (DHS). ICE and CBP may enforce the provisions of this part and ICE, as assisted by CBP may conduct investigations under this part. ...

  8. 15 CFR 30.73 - Enforcement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... procedures approved by the Attorney General. (b) Department of Homeland Security (DHS). ICE and CBP may enforce the provisions of this part and ICE, as assisted by CBP may conduct investigations under this part. ...

  9. 77 FR 12864 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, Inspection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ..., Inspection of Insured Structures by Communities AGENCY: Federal Emergency Management Agency, DHS. [email protected] . SUPPLEMENTARY INFORMATION: Collection of Information Title: Inspection of Insured Structures...

  10. 8 CFR 1003.104 - Filing of complaints; preliminary inquiries; resolutions; referral of complaints.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... practice before the Board and the Immigration Courts. Complaints of criminal, unethical, or unprofessional.... (2) Practitioners authorized to practice before DHS. Complaints of criminal, unethical, or...

  11. 8 CFR 1003.104 - Filing of complaints; preliminary inquiries; resolutions; referral of complaints.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... practice before the Board and the Immigration Courts. Complaints of criminal, unethical, or unprofessional.... (2) Practitioners authorized to practice before DHS. Complaints of criminal, unethical, or...

  12. 48 CFR 50.203 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... management protections for sellers of QATTs and others in the supply and distribution chain. (b) The SAFETY... website are block designations and block certifications granted by DHS. [72 FR 63030, Nov. 7, 2007, as...

  13. 48 CFR 50.203 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... management protections for sellers of QATTs and others in the supply and distribution chain. (b) The SAFETY... website are block designations and block certifications granted by DHS. [72 FR 63030, Nov. 7, 2007, as...

  14. 48 CFR 50.203 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... management protections for sellers of QATTs and others in the supply and distribution chain. (b) The SAFETY... website are block designations and block certifications granted by DHS. [72 FR 63030, Nov. 7, 2007, as...

  15. 48 CFR 50.203 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... management protections for sellers of QATTs and others in the supply and distribution chain. (b) The SAFETY... website are block designations and block certifications granted by DHS. [72 FR 63030, Nov. 7, 2007, as...

  16. DHS Cybersecurity Workforce Recruitment and Retention Act of 2014

    THOMAS, 113th Congress

    Sen. Carper, Thomas R. [D-DE

    2014-05-20

    Senate - 07/14/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 463. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  17. 20 CFR 655.80 - Notice to OFLC and DHS.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FOREIGN WORKERS IN THE UNITED STATES Labor Certification Process and Enforcement of Attestations for Temporary Employment in Occupations Other Than Agriculture or Registered Nursing in the United States (H-2B...

  18. 78 FR 29759 - Chemical Facility Anti-Terrorism Standards Personnel Surety Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ...), National Protection and Programs Directorate (NPPD), Office of Infrastructure Protection (IP... requirements and submitted by mail to the DHS/NPPD/IP/ ISCD CFATS Program Manager at the Department of Homeland...

  19. 75 FR 66115 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; FEMA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Request; FEMA Mitigation Success Story Database AGENCY: Federal Emergency Management Agency, DHS. ACTION... Database. Type of information collection: Revision of a currently approved information collection. [[Page...

  20. 77 FR 24656 - Extension of Port Limits of Indianapolis, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ...-0118. FOR FURTHER INFORMATION CONTACT: Roger Kaplan, Office of Field Operations, U.S. Customs and Border Protection, (202) 325-4543, or by email at Roger.Kaplan@dhs.gov . SUPPLEMENTARY INFORMATION: I...

  1. 48 CFR 3001.105-2 - Arrangement of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (FAR) 48 CFR 1.105-2. Guidance that is unique to a Component contains the organization's acronym or abbreviation directly following the title. The following acronyms apply: DHS Office of Procurement Operations...

  2. 48 CFR 3001.105-2 - Arrangement of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (FAR) 48 CFR 1.105-2. Guidance that is unique to a Component contains the organization's acronym or abbreviation directly following the title. The following acronyms apply: DHS Office of Procurement Operations...

  3. Staying Motivated During Tough Times

    NASA Technical Reports Server (NTRS)

    Cole, Jennifer H.

    2008-01-01

    This paper describes the problem of team motivation on a project. Our team was working with the Department of Homeland Security (DHS). The task consisted of figuring out how to safely control and land an airliner using just the thrust from the engines. This is called Throttles-Only Control (TOC). We weren't allowed to modify the airliner in any way, given the time and cost involved, and we had to use a stock airliner with line pilots. The idea was to give the pilots an emergency checklist which would provide them with the most useful information in the shortest time to learn how to fly TOC. The DHS Program office that was supporting us had its funding redirected, due to new priorities. The process of staying motivated for finishing as much of the project as possible is described.

  4. Reverse breeding: a novel breeding approach based on engineered meiosis.

    PubMed

    Dirks, Rob; van Dun, Kees; de Snoo, C Bastiaan; van den Berg, Mark; Lelivelt, Cilia L C; Voermans, William; Woudenberg, Leo; de Wit, Jack P C; Reinink, Kees; Schut, Johan W; van der Zeeuw, Eveline; Vogelaar, Aat; Freymark, Gerald; Gutteling, Evert W; Keppel, Marina N; van Drongelen, Paul; Kieny, Matthieu; Ellul, Philippe; Touraev, Alisher; Ma, Hong; de Jong, Hans; Wijnker, Erik

    2009-12-01

    Reverse breeding (RB) is a novel plant breeding technique designed to directly produce parental lines for any heterozygous plant, one of the most sought after goals in plant breeding. RB generates perfectly complementing homozygous parental lines through engineered meiosis. The method is based on reducing genetic recombination in the selected heterozygote by eliminating meiotic crossing over. Male or female spores obtained from such plants contain combinations of non-recombinant parental chromosomes which can be cultured in vitro to generate homozygous doubled haploid plants (DHs). From these DHs, complementary parents can be selected and used to reconstitute the heterozygote in perpetuity. Since the fixation of unknown heterozygous genotypes is impossible in traditional plant breeding, RB could fundamentally change future plant breeding. In this review, we discuss various other applications of RB, including breeding per chromosome.

  5. Reverse breeding: a novel breeding approach based on engineered meiosis

    PubMed Central

    Dirks, Rob; van Dun, Kees; de Snoo, C Bastiaan; van den Berg, Mark; Lelivelt, Cilia L C; Voermans, William; Woudenberg, Leo; de Wit, Jack P C; Reinink, Kees; Schut, Johan W; van der Zeeuw, Eveline; Vogelaar, Aat; Freymark, Gerald; Gutteling, Evert W; Keppel, Marina N; van Drongelen, Paul; Kieny, Matthieu; Ellul, Philippe; Touraev, Alisher; Ma, Hong; de Jong, Hans; Wijnker, Erik

    2009-01-01

    Reverse breeding (RB) is a novel plant breeding technique designed to directly produce parental lines for any heterozygous plant, one of the most sought after goals in plant breeding. RB generates perfectly complementing homozygous parental lines through engineered meiosis. The method is based on reducing genetic recombination in the selected heterozygote by eliminating meiotic crossing over. Male or female spores obtained from such plants contain combinations of non-recombinant parental chromosomes which can be cultured in vitro to generate homozygous doubled haploid plants (DHs). From these DHs, complementary parents can be selected and used to reconstitute the heterozygote in perpetuity. Since the fixation of unknown heterozygous genotypes is impossible in traditional plant breeding, RB could fundamentally change future plant breeding. In this review, we discuss various other applications of RB, including breeding per chromosome. PMID:19811618

  6. Effect of wave function on the proton induced L XRP cross sections for 62Sm and 74W

    NASA Astrophysics Data System (ADS)

    Shehla, Kaur, Rajnish; Kumar, Anil; Puri, Sanjiv

    2015-08-01

    The Lk(k= 1, α, β, γ) X-ray production cross sections have been calculated for 74W and 62Sm at different incident proton energies ranging 1-5 MeV using theoretical data sets of different physical parameters, namely, the Li(i=1-3) sub-shell X-ray emission rates based on the Dirac-Fork (DF) model, the fluorescence and Coster Kronig yields based on the Dirac- Hartree-Slater (DHS) model and two sets the proton ionization cross sections based on the DHS model and the ECPSSR in order to assess the influence of the wave function on the XRP cross sections. The calculated cross sections have been compared with the measured cross sections reported in the recent compilation to check the reliability of the calculated values.

  7. Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea

    PubMed Central

    Graf, Michael; Blaby, Ian K.; Makkay, Andrea M.; Starosta, Agata L.; Papke, R. Thane; Oshima, Tairo; Wilson, Daniel N.

    2016-01-01

    Translation initiation factor 5A (IF5A) is essential and highly conserved in Eukarya (eIF5A) and Archaea (aIF5A). The activity of IF5A requires hypusine, a posttranslational modification synthesized in Eukarya from the polyamine precursor spermidine. Intracellular polyamine analyses revealed that agmatine and cadaverine were the main polyamines produced in Haloferax volcanii in minimal medium, raising the question of how hypusine is synthesized in this halophilic Archaea. Metabolic reconstruction led to a tentative picture of polyamine metabolism and aIF5A modification in Hfx. volcanii that was experimentally tested. Analysis of aIF5A from Hfx. volcanii by LC-MS/MS revealed it was exclusively deoxyhypusinylated. Genetic studies confirmed the role of the predicted arginine decarboxylase gene (HVO_1958) in agmatine synthesis. The agmatinase-like gene (HVO_2299) was found to be essential, consistent with a role in aIF5A modification predicted by physical clustering evidence. Recombinant deoxyhypusine synthase (DHS) from S. cerevisiae was shown to transfer 4-aminobutyl moiety from spermidine to aIF5A from Hfx. volcanii in vitro. However, at least under conditions tested, this transfer was not observed with the Hfx. volcanii DHS. Furthermore, the growth of Hfx. volcanii was not inhibited by the classical DHS inhibitor GC7. We propose a model of deoxyhypusine synthesis in Hfx. volcanii that differs from the canonical eukaryotic pathway, paving the way for further studies. PMID:28053595

  8. Measuring Coverage in MNCH: Challenges in Monitoring the Proportion of Young Children with Pneumonia Who Receive Antibiotic Treatment

    PubMed Central

    Campbell, Harry; el Arifeen, Shams; Hazir, Tabish; O'Kelly, James; Bryce, Jennifer; Rudan, Igor; Qazi, Shamim Ahmad

    2013-01-01

    Pneumonia remains a major cause of child death globally, and improving antibiotic treatment rates is a key control strategy. Progress in improving the global coverage of antibiotic treatment is monitored through large household surveys such as the Demographic and Health Surveys (DHS) and the Multiple Indicator Cluster Surveys (MICS), which estimate antibiotic treatment rates of pneumonia based on two-week recall of pneumonia by caregivers. However, these survey tools identify children with reported symptoms of pneumonia, and because the prevalence of pneumonia over a two-week period in community settings is low, the majority of these children do not have true pneumonia and so do not provide an accurate denominator of pneumonia cases for monitoring antibiotic treatment rates. In this review, we show that the performance of survey tools could be improved by increasing the survey recall period or by improving either overall discriminative power or specificity. However, even at a test specificity of 95% (and a test sensitivity of 80%), the proportion of children with reported symptoms of pneumonia who truly have pneumonia is only 22% (the positive predictive value of the survey tool). Thus, although DHS and MICS survey data on rates of care seeking for children with reported symptoms of pneumonia and other childhood illnesses remain valid and important, DHS and MICS data are not able to give valid estimates of antibiotic treatment rates in children with pneumonia. PMID:23667338

  9. Trust and terrorism: citizen responses to anti-terrorism performance history.

    PubMed

    Johnson, Branden B

    2010-09-01

    The "intuitive detection theorists" model of trust posits greater trust for correctly distinguishing danger from safety and an activist response under uncertainty about danger. An American sample evaluated U.S. Department of Homeland Security (DHS) performance after two possible terrorism events in which DHS has the same activist or nonactivist response bias. Outcomes were two successes (bombing prevented or lack of threat accurately foretold), two failures (bombing or DHS action against high school prank leads to student deaths), or a mix. Hindsight empathy (a belief one would have made the same decision) differed across treatments but trust less so; contrary to a similar one-event experiment in Germany, an active but incorrect response did not raise trust relative to passive incorrect action. Political conservatives were much more trusting and empathetic than liberals, and all ideological groups (including moderates) exhibited little internal variation reflecting experimental conditions. Consistently accurate outcomes rated significantly higher in empathy than either inconsistent results or consistent inaccuracy (the lowest rated); trust exhibited no significant differences. Results in this study show actual (experimentally manipulated) performance being trumped by the interpretive screen of political ideology, but this seemed less the case in the earlier German study, despite its finding of a strong moderating effect of right-wing authoritarianism. Trust scholars need to attend more to effects of performance history (i.e., a sequence of events) and their limiting factors. More systematic testing of effects of ideology and performance history would enhance future research on trust. © 2010 Society for Risk Analysis.

  10. Influence of education level and experience on detection of approximal caries in digital dental radiographs. An in vitro study.

    PubMed

    Hellén-Halme, Kristina; Petersson, Gunnel Hänsel

    2010-01-01

    This study evaluated whether variations in education level and experience among dental staff influence the diagnostic accuracy of carious lesions on digital radiographs. Three student groups and a fourth group of general practitioners (Dentists) with more than five years of clinical experience participated in this study.The student groups were (i) dental students in their final (tenth) semester (DS-10), (ii) dental students in the sixth semester (DS-6) who just finished dental radiology training, and (iii) dental hygiene students (DHS) in their final (fourth) semester. Seven observers from each group participated. Standard radiographs of 100 extracted teeth (premolars and molars) were taken. The 28 observers evaluated the images for approximal carious lesions on a standard monitor. All evaluations were made in ambient light below 50 lux. Receiver operating characteristic curves were plotted to assess results. The standard criterion for healthy or carious lesions was a histological examination of sliced teeth. Kappa statistics evaluated intra-observer agreement. For carious lesions that had extended into the dentine, significant differences were found between (i) Dentists and all other groups, (ii) Dentists and DS-10 (p < 0.01), and (iii) Dentists and DS-6 and DHS (p < 0.001). Differences between DS-10 and DHS (p < or = 0.05) were also significant. In this study, education level and experience clearly influenced the diagnostic accuracy of approximal carious lesions that had extended into the dentine on digital radiographs.

  11. Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies

    PubMed Central

    Preukschas, Michael; Hagel, Christian; Schulte, Alexander; Weber, Kristoffer; Lamszus, Katrin; Sievert, Henning; Pällmann, Nora; Bokemeyer, Carsten; Hauber, Joachim; Braig, Melanie; Balabanov, Stefan

    2012-01-01

    Glioblastomas are highly aggressive brain tumors of adults with poor clinical outcome. Despite a broad range of new and more specific treatment strategies, therapy of glioblastomas remains challenging and tumors relapse in all cases. Recent work demonstrated that the posttranslational hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is a crucial regulator of cell proliferation, differentiation and an important factor in tumor formation, progression and maintenance. Here we report that eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient samples. Importantly, targeting eIF-5A and its hypusine modification with GC7, a specific DHS-inhibitor, showed a strong antiproliferative effect in glioblastoma cell lines in vitro, while normal human astrocytes were not affected. Furthermore, we identified p53 dependent premature senescence, a permanent cell cycle arrest, as the primary outcome in U87-MG cells after treatment with GC7. Strikingly, combined treatment with clinically relevant alkylating agents and GC7 had an additive antiproliferative effect in glioblastoma cell lines. In addition, stable knockdown of eIF-5A and DHS by short hairpin RNA (shRNA) could mimic the antiproliferative effects of GC7. These findings suggest that pharmacological inhibition of eIF-5A may represent a novel concept to treat glioblastomas and may help to substantially improve the clinical course of this tumor entity. PMID:22927971

  12. 48 CFR 22.1800 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Employment Eligibility Verification 22.1800 Scope. This... Security (DHS), United States Citizenship and Immigration Service's employment eligibility verification program (E-Verify) as the means for verifying employment eligibility of certain employees. ...

  13. 48 CFR 22.1800 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Employment Eligibility Verification 22.1800 Scope. This... Security (DHS), United States Citizenship and Immigration Service's employment eligibility verification program (E-Verify) as the means for verifying employment eligibility of certain employees. ...

  14. 77 FR 44641 - Critical Infrastructure Private Sector Clearance Program Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    .... DHS Sector Specialists or Protective Security Advisors email the form to the individual who then... clearance request form is signed by both the Federal official who nominated the applicant and the Assistant...

  15. 77 FR 61421 - Committee Name: Homeland Security Academic Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... social media and other means of communication to most effectively reach this audience; how to ensure that... findings and technologies that will make DHS operations more effective and efficient; how to create a...

  16. 76 FR 22911 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... discussions on professionalism of emergency management, approaches for National Incident Management System... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management...

  17. 33 CFR 101.510 - Assessment tools.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... may include: (a) DHS/TSA's vulnerability self-assessment tool located at http://www.tsa.gov/risk; and (b) USCG assessment tools, available from the cognizant COTP or at http://www.uscg.mil/hq/g-m/nvic...

  18. 78 FR 11671 - Advisory Committee on Commercial Operations of Customs and Border Protection (COAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... Term. 5. Discuss the Statement of Work and Next Steps regarding the Global Supply Chain Subcommittee... and Border Protection, Department of Homeland Security (DHS). ACTION: Committee Management; Notice of...

  19. 75 FR 18850 - National Protection and Programs Directorate; Chemical Facility Anti-Terrorism Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... Programs Directorate (NPPD), Office of Infrastructure Protection (IP), Infrastructure Security Compliance... submitted by mail to the DHS/NPPD/ IP/ISCD CFATS Program Manager at the Department of Homeland Security, 245...

  20. 6 CFR 11.4 - Collection by administrative offset.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... matter cannot be resolved by review of the documentary evidence alone. All travel expenses incurred by... submitted by both parties. (8) Burden of proof. DHS has the initial burden to prove the existence and amount...

  1. 75 FR 3912 - Agency Information Collection Activities: Proposed Collection; Comment Request, 1660-0076; Hazard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... Mitigation Grant Program Application and Reporting AGENCY: Federal Emergency Management Agency, DHS. ACTION... Hazard Mitigation Grant Program application and reporting requirements. DATES: Comments must be submitted... . [[Page 3913

  2. 48 CFR 3009.171-5 - Serious felonies prohibiting award.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Federal tax; (11) Trafficking in illegal drugs, alcohol, firearms, explosives, or other weapons; (12.... (b) The following is a list of offenses determined by DHS to be serious felonies for purposes of the...

  3. 48 CFR 3009.171-5 - Serious felonies prohibiting award.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Federal tax; (11) Trafficking in illegal drugs, alcohol, firearms, explosives, or other weapons; (12.... (b) The following is a list of offenses determined by DHS to be serious felonies for purposes of the...

  4. 48 CFR 3009.171-5 - Serious felonies prohibiting award.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Federal tax; (11) Trafficking in illegal drugs, alcohol, firearms, explosives, or other weapons; (12.... (b) The following is a list of offenses determined by DHS to be serious felonies for purposes of the...

  5. 8 CFR 292.3 - Professional conduct for practitioners-Rules and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... criminal, unethical, or unprofessional conduct, or in frivolous behavior, as set forth in 8 CFR 1003.102... before DHS. Complaints of criminal, unethical, or unprofessional conduct, or of frivolous behavior by a...

  6. 8 CFR 292.3 - Professional conduct for practitioners-Rules and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... criminal, unethical, or unprofessional conduct, or in frivolous behavior, as set forth in 8 CFR 1003.102... before DHS. Complaints of criminal, unethical, or unprofessional conduct, or of frivolous behavior by a...

  7. 8 CFR 292.3 - Professional conduct for practitioners-Rules and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... criminal, unethical, or unprofessional conduct, or in frivolous behavior, as set forth in 8 CFR 1003.102... before DHS. Complaints of criminal, unethical, or unprofessional conduct, or of frivolous behavior by a...

  8. 8 CFR 292.3 - Professional conduct for practitioners-Rules and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... criminal, unethical, or unprofessional conduct, or in frivolous behavior, as set forth in 8 CFR 1003.102... before DHS. Complaints of criminal, unethical, or unprofessional conduct, or of frivolous behavior by a...

  9. 75 FR 1799 - Terminate Long Range Aids to Navigation (Loran-C) Signal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... to Navigation (Loran-C) Signal AGENCY: U.S. Coast Guard, DHS. ACTION: Notice; correction. SUMMARY... 998). The document announced termination of the Long Range Aids to Navigation (Loran-C) Signal...

  10. 8 CFR 1003.47 - Identity, law enforcement, or security investigations or examinations relating to applications...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the record when the respondent receives the biometrics notice and instructions and the consequences... any biometric and other information necessary, DHS shall prepare such documents in keeping with...

  11. 8 CFR 1003.47 - Identity, law enforcement, or security investigations or examinations relating to applications...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the record when the respondent receives the biometrics notice and instructions and the consequences... any biometric and other information necessary, DHS shall prepare such documents in keeping with...

  12. 8 CFR 1003.47 - Identity, law enforcement, or security investigations or examinations relating to applications...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the record when the respondent receives the biometrics notice and instructions and the consequences... any biometric and other information necessary, DHS shall prepare such documents in keeping with...

  13. 8 CFR 1003.47 - Identity, law enforcement, or security investigations or examinations relating to applications...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the record when the respondent receives the biometrics notice and instructions and the consequences... any biometric and other information necessary, DHS shall prepare such documents in keeping with...

  14. 77 FR 51699 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... Operation Regulation; Cape Fear River, Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The Commander, Fifth Coast Guard District, has issued a temporary [[Page 51700

  15. DHS Accountability Act of 2012

    THOMAS, 112th Congress

    Rep. McCaul, Michael T. [R-TX-10

    2012-06-07

    Senate - 11/28/2012 Received in the Senate and Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  16. 77 FR 60901 - Safety Zone; Battle of Queenston Heights Bicentennial, Niagara River, Lewiston, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ..., Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of... Lower Niagara River near the Silo Restaurant, Lewiston, NY. The Captain of the Port Buffalo has...

  17. 48 CFR 3023.1004 - Requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Requirements. 3023.1004...-Know Laws and Pollution Requirements 3023.1004 Requirements. DHS Directive 023-02 Environmental... contain appropriate sustainable practices requirements, provisions and clauses. Contractors shall support...

  18. 48 CFR 3023.1004 - Requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Requirements. 3023.1004...-Know Laws and Pollution Requirements 3023.1004 Requirements. DHS Directive 023-02 Environmental... contain appropriate sustainable practices requirements, provisions and clauses. Contractors shall support...

  19. 48 CFR 3023.1004 - Requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Requirements. 3023.1004...-Know Laws and Pollution Requirements 3023.1004 Requirements. DHS Directive 023-02 Environmental... contain appropriate sustainable practices requirements, provisions and clauses. Contractors shall support...

  20. 76 FR 52672 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... instructions for submitting written comments. E-mail: [email protected]hq.dhs.gov . Include the docket number in the... call, the NSTAC members will receive an update regarding the progress of the NSTAC's Cloud Computing...

  1. Potential terrorist uses of highway-borne hazardous materials.

    DOT National Transportation Integrated Search

    2010-01-01

    The Department of Homeland Security (DHS) has requested that the Mineta Transportation Institutes National Transportation Security Center of Excellence (MTI NTSCOE) provide any research it has or insights it can provide on the security risks creat...

  2. 5 CFR 9701.212 - Bands.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... performance, recognizing and rewarding employees, and other associated duties. (c) DHS must document in... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF... MANAGEMENT SYSTEM Classification Classification Structure § 9701.212 Bands. (a) For purposes of identifying...

  3. 5 CFR 9701.212 - Bands.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... performance, recognizing and rewarding employees, and other associated duties. (c) DHS must document in... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF... MANAGEMENT SYSTEM Classification Classification Structure § 9701.212 Bands. (a) For purposes of identifying...

  4. 5 CFR 9701.212 - Bands.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... performance, recognizing and rewarding employees, and other associated duties. (c) DHS must document in... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF... MANAGEMENT SYSTEM Classification Classification Structure § 9701.212 Bands. (a) For purposes of identifying...

  5. 78 FR 65689 - Technical Mapping Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2013-0039] Technical Mapping Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management; Request for Applicants for Appointment to the Federal Emergency Management Agency's Technical...

  6. 48 CFR 3004.470-1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information Within Industry 3004.470-1 Scope. This section implements DHS's policies for assuring the security of unclassified facilities, Information Technology (IT) resources, and sensitive information during the...

  7. 48 CFR 3004.470-2 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... unclassified information. MD 4300.1, entitled Information Technology Systems Security, and the DHS Sensitive Systems Handbook, prescribe the policies and procedures on security for Information Technology resources... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information...

  8. A DHS Skunkworks Project: Defining and Addressing Homeland Security Grand Challenges

    DTIC Science & Technology

    2016-12-01

    Peter Diamandis, Ansari XPRIZE, market failure, technology, stealth technologies, Pasteur’s quadrant, Heilmeier Catechism, Homeland Security Advanced...Judging and Scoring ....................................................................27 D. OPTIMIZING FOR AN EMERGING MARKET ...37 Figure 3. Market /Technology Chart

  9. 78 FR 6732 - Changes to Standard Numbering System, Vessel Identification System, and Boating Accident Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... Boating Accident Report Database AGENCY: Coast Guard, DHS. ACTION: Rule; information collection approval... Identification System, and Boating Accident Report Database rule became effective on April 27, 2012. Under the...

  10. 77 FR 74630 - Medical Waivers for Merchant Mariner Credential Applicants With Anti-Tachycardia Devices or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... Cardioverter Defibrillators AGENCY: Coast Guard, DHS. ACTION: Notice to reopen public comment period. SUMMARY... implantable cardioverter defibrillators (ICDs). The public comment period for the notice expired on October 9...

  11. 76 FR 37269 - Safety Zone; Charleston Sharkfest Swim, Charleston Harbor, Charleston, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ...-AA00 Safety Zone; Charleston Sharkfest Swim, Charleston Harbor, Charleston, SC AGENCY: Coast Guard, DHS... waters of Charleston Harbor, in Charleston, South Carolina during the Charleston Sharkfest Swim on Sunday, [[Page 37270

  12. 77 FR 32656 - Critical Infrastructure Partnership Advisory Council (CIPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0008] Critical Infrastructure Partnership... Critical Infrastructure Partnership Advisory Council (CIPAC) by notice published in the Federal Register... Federal Officer, Critical Infrastructure Partnership Advisory Council, Sector Outreach and Programs...

  13. 77 FR 32655 - Critical Infrastructure Partnership Advisory Council (CIPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0009] Critical Infrastructure Partnership... the Critical Infrastructure Partnership Advisory Council (CIPAC) by notice published in the Federal... CONTACT: Larry May, Designated Federal Officer, Critical Infrastructure Partnership Advisory Council...

  14. 75 FR 21011 - Critical Infrastructure Partnership Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0032] Critical Infrastructure Partnership... Infrastructure Partnership Advisory Council (CIPAC) charter renewal. SUMMARY: The Department of Homeland Security... and Outreach Division, Office of Infrastructure Protection, National Protection and Programs...

  15. 75 FR 60771 - Critical Infrastructure Partnership Advisory Council (CIPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0080] Critical Infrastructure Partnership..., Section Chief Partnership Programs, Partnership and Outreach Division, Office of Infrastructure Protection... Outreach Division, Office of Infrastructure Protection, National Protection and Programs Directorate...

  16. 78 FR 54755 - Extension of Port Limits of Indianapolis, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ... INFORMATION CONTACT: Roger Kaplan, Office of Field Operations, U.S. Customs and Border Protection, by phone at (202) 325- 4543, or by email at Roger.Kaplan@dhs.gov . SUPPLEMENTARY INFORMATION: I. Background In a...

  17. 76 FR 3648 - NIMS Training Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2009-0012] NIMS Training Plan AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of availability; request for comments. SUMMARY: The Federal Emergency Management Agency (FEMA) is requesting public...

  18. DHS Internship Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    House, Samantha

    2014-09-01

    This summer I worked on projects that involved RNA sequencing of pathogens after an infection of host cells. The goal of these projects was to continue developing pathogen enrichment strategies for transcriptomic analysis, and also to perform hostpathogen interaction studies.

  19. 5 CFR 9701.107 - Program evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....107 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM General Provisions § 9701.107 Program evaluation. (a) DHS will establish...

  20. 5 CFR 9701.101 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES... establishment of a new human resources management system within the Department of Homeland Security (DHS), as...

  1. 5 CFR 9701.501 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES... Department's mission foremost in mind. The regulations also recognize the rights of DHS employees to organize...

  2. 78 FR 70569 - Technical Mapping Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2013-0039] Technical Mapping Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice... Technical Mapping Advisory Council (TMAC). The notice incorrectly stated that contractors and potential...

  3. Performance of Dispersed Fringe Sensor in the Presence of Segmented Mirror Aberrations: Modeling and Simulation

    NASA Technical Reports Server (NTRS)

    Shi, Fang; Basinger, Scott A.; Redding, David C.

    2006-01-01

    Dispersed Fringe Sensing (DFS) is an efficient and robust method for coarse phasing of a segmented primary mirror such as the James Webb Space Telescope (JWST). In this paper, modeling and simulations are used to study the effect of segmented mirror aberrations on the fringe image, DFS signals and DFS detection accuracy. The study has shown due to the pixilation spatial filter effect from DFS signal extraction the effect of wavefront error is reduced and DFS algorithm will be more robust against wavefront aberration by using multi-trace DFS approach. We also studied the JWST Dispersed Hartmann Sensor (DHS) performance in presence of wavefront aberrations caused by the gravity sag and we use the scaled gravity sag to explore the JWST DHS performance relationship with the level of the wavefront aberration. This also includes the effect from line-of-sight jitter.

  4. A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity

    PubMed Central

    Wollam, Joshua; Magner, Daniel B.; Magomedova, Lilia; Rass, Elisabeth; Shen, Yidong; Rottiers, Veerle; Habermann, Bianca; Cummins, Carolyn L.; Antebi, Adam

    2012-01-01

    Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs) regulate developmental timing and longevity through the conserved nuclear hormone receptor DAF-12, a homolog of mammalian sterol-regulated receptors LXR and FXR. Using metabolic genetics, mass spectrometry, and biochemical approaches, we identify new activities in DA biosynthesis and characterize an evolutionarily conserved short chain dehydrogenase, DHS-16, as a novel 3-hydroxysteroid dehydrogenase. Through regulation of DA production, DHS-16 controls DAF-12 activity governing longevity in response to signals from the gonad. Our elucidation of C. elegans bile acid biosynthetic pathways reveals the possibility of novel ligands as well as striking biochemical conservation to other animals, which could illuminate new targets for manipulating longevity in metazoans. PMID:22505847

  5. Consistency in reporting condom use between husbands and wives in Bangladesh.

    PubMed

    Islam, Mohammad Amirul; Padmadas, Sabu S; Smith, Peter W F

    2010-07-01

    Consistency in reporting contraceptive use between spouses is little understood, especially in developing settings. This research challenges the accuracy of measuring contraceptive prevalence rate, which is traditionally calculated based on women's responses. Multinomial logistic regression techniques are employed on a couple dataset from the 1999-2000 Bangladesh Demographic and Health Survey (DHS) to investigate the consistency in reporting condom use between husbands and wives. The level of inconsistency in reporting condom use was about 46%, of which about 32% was explained by husbands reporting condom use while wives did not, and 14% by wives reporting condom use while husbands did not. Regression analysis showed that couple education and age difference between the spouses are significant determinants of inconsistent reporting behaviour. The findings suggest the need for alternative approaches (questions) in the DHS to ensure consistency in the collection of data related to use of family planning methods.

  6. Effect of wave function on the proton induced L XRP cross sections for {sub 62}Sm and {sub 74}W

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shehla,; Kaur, Rajnish; Kumar, Anil

    The L{sub k}(k= 1, α, β, γ) X-ray production cross sections have been calculated for {sub 74}W and {sub 62}Sm at different incident proton energies ranging 1-5 MeV using theoretical data sets of different physical parameters, namely, the Li(i=1-3) sub-shell X-ray emission rates based on the Dirac-Fork (DF) model, the fluorescence and Coster Kronig yields based on the Dirac- Hartree-Slater (DHS) model and two sets the proton ionization cross sections based on the DHS model and the ECPSSR in order to assess the influence of the wave function on the XRP cross sections. The calculated cross sections have been compared withmore » the measured cross sections reported in the recent compilation to check the reliability of the calculated values.« less

  7. Trends in reproductive behavior among young single women in Colombia and Peru: 1985-1999.

    PubMed

    Ali, Mohamed M; Cleland, John; Shah, Iqbal H

    2003-11-01

    Using "calendar" data for single women aged 15-24 from successive Demographic and Health Surveys (DHS) conducted in Colombia and Peru during the 1990s, we document trends, year by year, in sexual activity, the use of contraceptives, and subsequent reproductive outcomes. We provide evidence of the important and hitherto largely untapped potential of DHS calendar data to draw complete sexual and reproductive profiles when data from various surveys are integrated. Over the period 1985-1999, young single women in both Colombia and Peru became sexually active at younger ages. The use of contraceptives, especially the use of condoms, increased but did not fully offset the rise in sexual activity, and thus the incidence of premarital conceptions rose among young single women. In both countries, sharp declines occurred in the proportion of premaritally conceived births that were reported as being wanted.

  8. Improving the Measurement of Fertility Regulation Practices: Findings from Qualitative Research in Ghana.

    PubMed

    Marston, Cicely; Renedo, Alicia; Nyaaba, Gertrude Nsorma; Machiyama, Kazuyo; Tapsoba, Placide; Cleland, John

    2017-09-01

    According to Demographic and Health Survey (DHS) data, highly educated urban women in some West African countries simultaneously have low rates of both contraceptive use and fertility-suggesting that the DHS may not be capturing a complete picture of women's contraceptive practices. Individual in-depth interviews and focus group discussions were conducted with a total of 48 women aged 18-49 in Accra, Ghana, who had at least a secondary education to explore their reproductive lives and relationships, and their views on and use of fertility regulation strategies. Data were analyzed using iterative thematic techniques. Women commonly reported using combinations of contraceptive methods, including "counting days" (using a calendar and the date of one's last menstrual period to estimate "unsafe" days-those on which the risk of conception is high), as well as withdrawal, condoms and frequent use of emergency contraceptive pills. Women described practicing "periodic contraception": for example, counting days to determine unsafe days and practicing contraception ad hoc on such days. Method use combinations varied from cycle to cycle-forming a "mosaic" of method use combinations over time. The fertility control strategies commonly reported by the study respondents-periodic contraception, and frequent use of traditional methods and emergency contraceptive pills-are likely not adequately captured in general surveys such as the DHS. Such surveys are also not well suited to measuring combinations of methods and mosaics of method combinations. New ways of capturing women's fertility regulation practices should be considered, including additional survey items, new question modules and specialist studies.

  9. Interagency Biological Restoration Demonstration (IBRD): a collaborative approach to biological incident recovery.

    PubMed

    Crockett, Katie

    2011-09-01

    Following the terrorist attacks in 2001, much time and effort has been put toward improving catastrophic incident response. But recovery--the period following initial response that focuses on the long-term viability of the affected area--has received less attention. Recognizing the importance of being able to recover an area following a catastrophic incident, the Department of Defense, through its Defense Threat Reduction Agency (DTRA), and the Department of Homeland Security, through its Science and Technology Directorate (DHS S&T), created the Interagency Biological Restoration Demonstration (IBRD) program. IBRD was a 4-year program jointly managed and funded by DTRA and DHS S&T, the goal of which was to reduce the time and resources necessary to recover a wide urban area from an intentional release of Bacillus anthracis. Specific program objectives included understanding the social, economic, and operational interdependencies that affect recovery; establishing long-term coordination between the Departments of Defense and Homeland Security; developing strategic recovery/restoration plans; identifying and demonstrating technologies that support recovery; and exercising recovery activities and technology solutions. IBRD has made important first steps toward improving national preparedness in the area biological incident recovery. Specifically, IBRD has helped enhance the efficacy and efficiency of recovering large urban areas by developing consequence management guidance; identifying key S&T capabilities and integrating them with planning and guidance documents; and establishing key relationships across the federal interagency, federal-to-regional, civilian-to-military, and public-to-private stakeholders. Upon completion of IBRD in fall 2010, both DTRA and DHS S&T planned follow-on programs.

  10. Development of an Autonomous Lidar Instrument for Use on a UAV Platform in Support of Homeland Security

    NASA Technical Reports Server (NTRS)

    McGill, Matthew; Famiglietti, Joe

    2005-01-01

    Researchers at NASA's Goddard Space Flight Center have developed an autonomous aerosol backscatter lidar instrument for use on the high-altitude ER-2 aircraft (for more information please visit http://cpl.gsfc.nasa.gov). Work is currently underway to transfer this instrument to a UAV platform such as Global Hawk. While the NASA applications are Earth science and satellite validation, there is clearly a Homeland Security application for such an instrument. One novel concept is to have a fleet of UAVs stationed around the country, each UAV having a payload including a lidar instrument. In the event of attack, the appropriate UAV(s) could be launched for purposes of, e.g., plume detection and tracking that are critical for decision support. While the existing lidar instrument is not directly capable of biological species discrimination, it is capable of plume tracking and thus can demonstrate to DHS the capabilities and utility of such instruments. Using NASA funding we will have an instrument ready to fly on Global Hawk by end of 2005. We would like to find partners, either within private industry or within DHS who would be willing to contribute aircraft access and flight hours for a demonstration flight. Longer-term partnerships to develop more advanced and more capable types of lidar instruments are also desirable. In this presentation we will detail the existing ER-2 lidar instrument and show measurement results, show the progress made on adapting to the Global Hawk platform, present concepts for DHS uses of such instruments, and openly pursue partnership opportunities.

  11. DOE/DHS INDUSTRIAL CONTROL SYSTEM CYBER SECURITY PROGRAMS: A MODEL FOR USE IN NUCLEAR FACILITY SAFEGUARDS AND SECURITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robert S. Anderson; Mark Schanfein; Trond Bjornard

    2011-07-01

    Many critical infrastructure sectors have been investigating cyber security issues for several years especially with the help of two primary government programs. The U.S. Department of Energy (DOE) National SCADA Test Bed and the U.S. Department of Homeland Security (DHS) Control Systems Security Program have both implemented activities aimed at securing the industrial control systems that operate the North American electric grid along with several other critical infrastructure sectors (ICS). These programs have spent the last seven years working with industry including asset owners, educational institutions, standards and regulating bodies, and control system vendors. The programs common mission is tomore » provide outreach, identification of cyber vulnerabilities to ICS and mitigation strategies to enhance security postures. The success of these programs indicates that a similar approach can be successfully translated into other sectors including nuclear operations, safeguards, and security. The industry regulating bodies have included cyber security requirements and in some cases, have incorporated sets of standards with penalties for non-compliance such as the North American Electric Reliability Corporation Critical Infrastructure Protection standards. These DOE and DHS programs that address security improvements by both suppliers and end users provide an excellent model for nuclear facility personnel concerned with safeguards and security cyber vulnerabilities and countermeasures. It is not a stretch to imagine complete surreptitious collapse of protection against the removal of nuclear material or even initiation of a criticality event as witnessed at Three Mile Island or Chernobyl in a nuclear ICS inadequately protected against the cyber threat.« less

  12. Investigating determinants of yawning in the domestic (Equus caballus) and Przewalski (Equus ferus przewalskii) horses.

    PubMed

    Górecka-Bruzda, Aleksandra; Fureix, Carole; Ouvrard, Anne; Bourjade, Marie; Hausberger, Martine

    2016-10-01

    Yawning is rare in herbivores which therefore may be an interesting group to disentangle the potential function(s) of yawning behaviour. Horses provide the opportunity to compare not only animals living in different conditions but also wild versus domestic species. Here, we tested three hypotheses by observing both domestic and Przewalski horses living in semi-natural conditions: (i) that domestic horses may show an elevated rate of yawning as a result of the domestication process (or as a result of life conditions), (ii) that individuals experiencing a higher level of social stress would yawn more than individuals with lower social stress and (iii) that males would yawn more often than females. The study involved 19 Przewalski horses (PHs) and 16 domestic horses (DHs) of different breeds living in large outdoor enclosures. The results showed that there was no difference between the PH and DH in yawning frequency (YF). PHs exhibited much higher levels of social interactions than DHs. There was a positive correlation between yawning frequency and aggressive behaviours in PHs, especially males, supporting the idea that yawning may be associated with more excitatory/stressful social situations. A correlation was found between yawning frequency and affiliative behaviours in DHs, which supports the potential relationship between yawning and social context. Finally, the entire males, but not castrated males, showed much higher levels of yawning than females in both species. The intensity (rather than the valence) of the interaction may be important in triggering yawning, which could therefore be a displacement activity that helps reduce tension.

  13. The association between female genital fistula symptoms and gender-based violence: A multicountry secondary analysis of household survey data.

    PubMed

    Mallick, Lindsay; Tripathi, Vandana

    2018-01-01

    The Demographic and Health Surveys (DHS), which include standardised questions on female genital fistula symptoms, provide a unique opportunity to evaluate the epidemiology of fistula. This study sought to examine associations between self-reported fistula symptoms and experience of gender-based violence (GBV) among women interviewed in DHS surveys. This study used data from thirteen DHS surveys with standardised fistula and domestic violence modules. Data from the most recent survey in each country were pooled, weighting each survey equally. Multivariable logistic regressions controlled for maternal and demographic factors. Prevalence of fistula symptoms in this sample of 95 625 women ranges from 0.3% to 1.8% by country. The majority of women reporting fistula symptoms (56%) have ever experienced physical violence, and more than one-quarter have ever experienced sexual violence (27%), compared with 38% and 13% among women with no symptoms, respectively. Similarly, 16% of women with fistula symptoms report recently experiencing sexual violence-twice the percentage among women not reporting symptoms (8%). Women whose first experience of sexual violence was from a non-partner have almost four times the odds of reporting fistula symptoms compared with women who never experienced sexual violence. These associations indicate a need to investigate temporal and causal relationships between violence and fistula. The increased risk of physical and sexual violence among women with fistula symptoms suggests that fistula programmes should incorporate GBV into provider training and services. © 2017 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

  14. Investigating determinants of yawning in the domestic ( Equus caballus) and Przewalski ( Equus ferus przewalskii) horses

    NASA Astrophysics Data System (ADS)

    Górecka-Bruzda, Aleksandra; Fureix, Carole; Ouvrard, Anne; Bourjade, Marie; Hausberger, Martine

    2016-10-01

    Yawning is rare in herbivores which therefore may be an interesting group to disentangle the potential function(s) of yawning behaviour. Horses provide the opportunity to compare not only animals living in different conditions but also wild versus domestic species. Here, we tested three hypotheses by observing both domestic and Przewalski horses living in semi-natural conditions: (i) that domestic horses may show an elevated rate of yawning as a result of the domestication process (or as a result of life conditions), (ii) that individuals experiencing a higher level of social stress would yawn more than individuals with lower social stress and (iii) that males would yawn more often than females. The study involved 19 Przewalski horses (PHs) and 16 domestic horses (DHs) of different breeds living in large outdoor enclosures. The results showed that there was no difference between the PH and DH in yawning frequency (YF). PHs exhibited much higher levels of social interactions than DHs. There was a positive correlation between yawning frequency and aggressive behaviours in PHs, especially males, supporting the idea that yawning may be associated with more excitatory/stressful social situations. A correlation was found between yawning frequency and affiliative behaviours in DHs, which supports the potential relationship between yawning and social context. Finally, the entire males, but not castrated males, showed much higher levels of yawning than females in both species. The intensity (rather than the valence) of the interaction may be important in triggering yawning, which could therefore be a displacement activity that helps reduce tension.

  15. Factors influencing leaf litter decomposition: An intersite decomposition experiment across China

    USGS Publications Warehouse

    Zhou, G.; Guan, L.; Wei, X.; Tang, X.; Liu, S.; Liu, J.; Zhang, Dongxiao; Yan, J.

    2008-01-01

    The Long-Term Intersite Decomposition Experiment in China (hereafter referred to as LTIDE-China) was established in 2002 to study how substrate quality and macroclimate factors affect leaf litter decomposition. The LTIDE-China includes a wide variety of natural and managed ecosystems, consisting of 12 forest types (eight regional broadleaf forests, three needle-leaf plantations and one broadleaf plantation) at eight locations across China. Samples of mixed leaf litter from the south subtropical evergreen broadleaf forest in Dinghushan (referred to as the DHS sample) were translocated to all 12 forest types. The leaf litter from each of other 11 forest types was placed in its original forest to enable comparison of decomposition rates of DHS and local litters. The experiment lasted for 30 months, involving collection of litterbags from each site every 3 months. Our results show that annual decomposition rate-constants, as represented by regression fitted k-values, ranged from 0.169 to 1.454/year. Climatic factors control the decomposition rate, in which mean annual temperature and annual actual evapotranspiration are dominant and mean annual precipitation is subordinate. Initial C/N and N/P ratios were demonstrated to be important factors of regulating litter decomposition rate. Decomposition process may apparently be divided into two phases controlled by different factors. In our study, 0.75 years is believed to be the dividing line of the two phases. The fact that decomposition rates of DHS litters were slower than those of local litters may have been resulted from the acclimation of local decomposer communities to extraneous substrate. ?? 2008 Springer Science+Business Media B.V.

  16. DHS Acquisition Accountability and Efficiency Act

    THOMAS, 113th Congress

    Rep. Duncan, Jeff [R-SC-3

    2014-03-13

    Senate - 06/10/2014 Received in the Senate and Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  17. 5 CFR 9701.601 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF... MANAGEMENT SYSTEM Adverse Actions General § 9701.601 Purpose. This subpart contains regulations prescribing..., or removed. DHS may issue implementing directives to carry out the provisions of this subpart. ...

  18. 5 CFR 9701.601 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF... MANAGEMENT SYSTEM Adverse Actions General § 9701.601 Purpose. This subpart contains regulations prescribing..., or removed. DHS may issue implementing directives to carry out the provisions of this subpart. ...

  19. 48 CFR 3019.201 - General policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (d) DHS is committed to a unified team approach involving senior management, small business specialists, acquisition personnel and program staff to support both critical homeland security missions and meet public policy objectives concerning small business participation in departmental procurements. The...

  20. 48 CFR 3019.201 - General policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (d) DHS is committed to a unified team approach involving senior management, small business specialists, acquisition personnel and program staff to support both critical homeland security missions and meet public policy objectives concerning small business participation in departmental procurements. The...

  1. 76 FR 72427 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ...: [email protected]hq.dhs.gov . Include the docket number in the subject line of the email message. Fax: (703) 235... receive an update from the Cloud Computing Subcommittee, and receive an update on the National Public...

  2. 76 FR 24503 - Agency Information Collection Activities: DHS Individual Complaint of Employment Discrimination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... employment for all persons, to prohibit discrimination in employment because of race, color, religion, sex... Act (Title VII) (42 U.S.C. 2000e et seq.) (race, color, religion, sex, national origin), the Age...

  3. 78 FR 15968 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management... Management Agency (FEMA) is requesting individuals who are interested in serving on the National Advisory...

  4. 77 FR 9953 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management... Management Agency (FEMA) is requesting individuals who are interested in serving on the National Advisory...

  5. 48 CFR 3023.1002 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Applicability. 3023.1002 Section 3023.1002 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND... 3023.1002 Applicability. DHS MD 5110, Environmental Compliance, provides guidance and direction for...

  6. 75 FR 6681 - National Disaster Recovery Framework

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2010-0004] National Disaster Recovery Framework AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of availability; request for comments. SUMMARY: The Federal Emergency Management Agency (FEMA), in coordination...

  7. 76 FR 55079 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0063] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...) 282-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445...

  8. 76 FR 58813 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0096] Homeland Security Advisory Council... meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445, 245...

  9. 77 FR 64532 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0064] Homeland Security Advisory Council... meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445, 245...

  10. 78 FR 64230 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... the data privacy- related issues addressed by small- to medium-sized enterprises; and 3. Other... information on a case-by-case basis as required by law or as necessary for a specific purpose, as described in...

  11. 75 FR 18524 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2008-0010] National Fire Academy Board of Visitors AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management; Notice of Open Federal Advisory Committee Meeting. [[Page 18525

  12. 77 FR 75182 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Friday, January 11, 2013, via... related to national security and emergency preparedness telecommunications policy. Agenda: The NSTAC...

  13. 78 FR 45255 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. [[Page 45256... President's National Security Telecommunications Advisory Committee (NSTAC) will meet on Tuesday, August 20... related to national security and emergency preparedness (NS/EP) telecommunications policy. Agenda: The...

  14. 77 FR 7597 - Waiver of Debt

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2012-0006] Waiver of Debt AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: FEMA is... SW., Washington, DC 20472. FOR FURTHER INFORMATION CONTACT: Keith Turi, Federal Emergency Management...

  15. 76 FR 20995 - Critical Infrastructure Partnership Advisory Council (CIPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0028] Critical Infrastructure Partnership... Critical Infrastructure Partnership Advisory Council (CIPAC) by notice published in the Federal Register... Infrastructure Protection, National Protection and Programs Directorate, U.S. Department of Homeland Security...

  16. 75 FR 82037 - National Protection and Programs Directorate; President's National Security Telecommunications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0050] National Protection and Programs Directorate; President's National Security Telecommunications Advisory Committee AGENCY: National Protection... Committee Meeting. SUMMARY: The President's National Security Telecommunications Advisory Committee (NSTAC...

  17. 77 FR 38306 - GFIRST Conference Stakeholder Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ...), National Cyber Security Division (NCSD), United States Computer Emergency Readiness Team (US-CERT) will...- CERT, [email protected] . SUPPLEMENTARY INFORMATION: GFIRST is DHS's premier cyber conference and continually seeks to enhance collaborative efforts among cyber constituencies, partners, and stakeholders. The...

  18. 6 CFR 11.14 - Receipt of offset requests by other Federal agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to the existence or the amount of the debt. When two or more agencies are seeking offsets from... offset simultaneously. For the purposes of this section, debts owed to DHS generally take precedence over...

  19. 6 CFR 11.14 - Receipt of offset requests by other Federal agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to the existence or the amount of the debt. When two or more agencies are seeking offsets from... offset simultaneously. For the purposes of this section, debts owed to DHS generally take precedence over...

  20. 76 FR 69755 - National Disaster Recovery Framework (NDRF)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2010-0004] National Disaster Recovery Framework (NDRF) AGENCY: Federal Emergency Management Agency, DHS. ACTION... Framework (NRF) to provide organizing constructs and principles solely focused on disaster recovery...

Some links on this page may take you to non-federal websites. Their policies may differ from this site.
Top