Van Gogh and lithium. Creativity and bipolar disorder: perspective of a writer/photographer.

PubMed

Dennison, D

1999-12-01

Diana Dennison has suffered from manic depression since her teenage years in the 1960s but only realised that she had the condition when, in her 30s, she learnt that her uncle was manic depressive. Diana endured her low states with either no medication or with what was for her the unsatisfactory effect of tricyclic antidepressants. Her untreated hypomanic states cut a swathe through her life. She has never been hospitalised for her condition. Her marriage did not survive but her daughters did and she is now a proud and doting grandmother who skis and scuba dives. Only in the last 4 years did Diana seek help for the treatment of her condition. Diana is a free-lance writer, researcher and photographer.

Literary Crossover in the Domingo Del Monte "Tertulia": Anselmo Suárez Y Romero's and Cirilo Villaverde's C. Valdés Protagonists

ERIC Educational Resources Information Center

Myers, Megan Jeanette

2017-01-01

This article charts the similarities between the first short story appearance in 1839 of what later became Cirilo Villaverde's well-known nineteenth-century novel, "Cecilia Valdés" (1882), and Anselmo Suárez y Romero's "Carlota Valdés" (1838). The study considers the circle of influence in Cuba for writers during this time…

DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows.

PubMed

Paraskevopoulou, Maria D; Georgakilas, Georgios; Kostoulas, Nikos; Vlachos, Ioannis S; Vergoulis, Thanasis; Reczko, Martin; Filippidis, Christos; Dalamagas, Theodore; Hatzigeorgiou, A G

2013-07-01

MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression through mRNA degradation and/or translation repression, affecting many biological processes. DIANA-microT web server (http://www.microrna.gr/webServer) is dedicated to miRNA target prediction/functional analysis, and it is being widely used from the scientific community, since its initial launch in 2009. DIANA-microT v5.0, the new version of the microT server, has been significantly enhanced with an improved target prediction algorithm, DIANA-microT-CDS. It has been updated to incorporate miRBase version 18 and Ensembl version 69. The in silico-predicted miRNA-gene interactions in Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans exceed 11 million in total. The web server was completely redesigned, to host a series of sophisticated workflows, which can be used directly from the on-line web interface, enabling users without the necessary bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses. For instance, one available pipeline performs miRNA target prediction using different thresholds and meta-analysis statistics, followed by pathway enrichment analysis. DIANA-microT web server v5.0 also supports a complete integration with the Taverna Workflow Management System (WMS), using the in-house developed DIANA-Taverna Plug-in. This plug-in provides ready-to-use modules for miRNA target prediction and functional analysis, which can be used to form advanced high-throughput analysis pipelines.

DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows

PubMed Central

Paraskevopoulou, Maria D.; Georgakilas, Georgios; Kostoulas, Nikos; Vlachos, Ioannis S.; Vergoulis, Thanasis; Reczko, Martin; Filippidis, Christos; Dalamagas, Theodore; Hatzigeorgiou, A.G.

2013-01-01

MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression through mRNA degradation and/or translation repression, affecting many biological processes. DIANA-microT web server (http://www.microrna.gr/webServer) is dedicated to miRNA target prediction/functional analysis, and it is being widely used from the scientific community, since its initial launch in 2009. DIANA-microT v5.0, the new version of the microT server, has been significantly enhanced with an improved target prediction algorithm, DIANA-microT-CDS. It has been updated to incorporate miRBase version 18 and Ensembl version 69. The in silico-predicted miRNA–gene interactions in Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans exceed 11 million in total. The web server was completely redesigned, to host a series of sophisticated workflows, which can be used directly from the on-line web interface, enabling users without the necessary bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses. For instance, one available pipeline performs miRNA target prediction using different thresholds and meta-analysis statistics, followed by pathway enrichment analysis. DIANA-microT web server v5.0 also supports a complete integration with the Taverna Workflow Management System (WMS), using the in-house developed DIANA-Taverna Plug-in. This plug-in provides ready-to-use modules for miRNA target prediction and functional analysis, which can be used to form advanced high-throughput analysis pipelines. PMID:23680784

Diana H. Wall, ESA President 1999-2000

USGS Publications Warehouse

Baron, Jill S.; Parsons, A.

2000-01-01

A more polite term for workaholic is over-achiever, and Diana Harrison Wall could easily serve as the type specimen for both words. Her ability to multi-task is a great boon for the Ecological Society of America. That characteristic drive has also been essential to Wall’s own personal success, since it pushed her to persevere during the lean years when a woman’s place was NOT in the field or laboratory. Diana is a very strong role model for young ecologists through her enthusiasm for science, her remarkable scientific achievements, and her leadership skills. In addition to advising her many graduate students, Diana-as-role-model has been featured in many news media, including PBS TV shows such as “Horizons” and “Discovery,” National Geographic magazine, and the New York Times. She is highlighted on the ESA Web site: “What Do Ecologists Do? Focus on Ecologists.”

Addressing Commanders’ Needs for Information on Soft Factors

DTIC Science & Technology

2011-01-01

international aFFairs law and Business national seCurity population and aging puBliC saFety sCienCe and teChnology terrorism and homeland seCurity this...Operations, by Eric V. Larson, Richard E. Darilek, Dalia Dassa Kaye, Forrest E. Morgan, Brian Nichiporuk, Diana Dunham-Scott, Cathryn Quantic Thurston...Richardson, Lowell H. Schwartz, and Cathryn Quantic Thurston, MG-654-A, 2009 (available at http://www.rand.org/pubs/monographs/MG654.html) and

Operation minute gun, shot Diana Moon. Summary report. (Sanitized version)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bower, J.A.B.; Nance, O.A.

1973-12-31

Typical device diagnostic experiments such as filter fluorescers, a calorimeter, a pinhole camera, a bent crystal spectrometer, and passive dosimetry were also present on Diana Moon. The test was considered a complete success with over 95 percent of the experimental data being recovered.

DIANA - A deep underground accelerator for nuclear astrophysics experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winklehner, Daniel; Leitner, Daniela; Lemut, Alberto

DIANA (Dakota Ion Accelerator for Nuclear Astrophysics) is a proposed facility designed to be operated deep underground. The DIANA collaboration includes nuclear astrophysics groups from Lawrence Berkeley National Laboratory, Michigan State University, Western Michigan University, Colorado School of Mines, and the University of North Carolina, and is led by the University of Notre Dame. The scientific goals of the facility are measurements of low energy nuclear cross-sections associated with sun and pre-supernova stars in a laboratory setup at energies that are close to those in stars. Because of the low stellar temperatures associated with these environments, and the high Coulombmore » barrier, the reaction cross-sections are extremely low. Therefore these measurements are hampered by small signal to background ratios. By going underground the background due to cosmic rays can be reduced by several orders of magnitude. We report on the design status of the DIANA facility with focus on the 3 MV electrostatic accelerator.« less

DIANA: A multi-phase, multi-component hydrodynamic model for the analysis of severe accidents in heavy water reactors with multiple-tube assemblies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tentner, A.M.

1994-03-01

A detailed hydrodynamic fuel relocation model has been developed for the analysis of severe accidents in Heavy Water Reactors with multiple-tube Assemblies. This model describes the Fuel Disruption and Relocation inside a nuclear fuel assembly and is designated by the acronym DIANA. DIANA solves the transient hydrodynamic equations for all the moving materials in the core and treats all the relevant flow regimes. The numerical solution techniques and some of the physical models included in DIANA have been developed taking advantage of the extensive experience accumulated in the development and validation of the LEVITATE (1) fuel relocation model of SAS4Amore » [2, 3]. The model is designed to handle the fuel and cladding relocation in both voided and partially voided channels. It is able to treat a wide range of thermal/ hydraulic/neutronic conditions and the presence of various flow regimes at different axial locations within the same hydrodynamic channel.« less

Diana Al-Hadid: Identity and Heritage

ERIC Educational Resources Information Center

Jungerberg, Tom; Smith, Anna; Borsh, Colleen

2012-01-01

Diana Al-Hadid's sculptures reflect the many locations, cultures, histories, and mythologies that have shaped her as an artist. In large-scale works which have the appearance of architectural ruins, Al-Hadid employs imagery drawn from many diverse interests including science and technology, history, and literature. She also incorporates images and…

Approaches to Research Priorities for Policy: A Comparative Study. Occasional Paper

ERIC Educational Resources Information Center

Wilkinson, Diana

2010-01-01

Diana Wilkinson, Chief Social Researcher with the Scottish Government, assisted National Centre for Vocational Education Research (NCVER) to facilitate a forum to discuss the development of national research priorities for the vocational education and training sector. This paper summarises Diana Wilkinson's impression of the forum and uses two…

Diana Leonard and Materialist Feminism

ERIC Educational Resources Information Center

Jackson, Stevi

2013-01-01

This tribute to Diana Leonard focuses on her contribution to materialist feminism, both through bringing the work of key French theorists to the attention of an Anglophone audience and through her own sociological work on the family, marriage and childhood. In so doing it draws attention to the importance of her work as editor and…

Taking a Giant Step into Our Technological Future. A Talk with Diana Oshiro.

ERIC Educational Resources Information Center

Speidel, Gisela E.

1995-01-01

Diana Oshiro, Assistant Superintendent for the Office of Information and Telecommunications Services, Hawaii State Department of Education, supervises voice, data, video, and information systems serving the department. This article presents an interview in which she discusses the importance of technology in education and describes the need for…

DIANA-microT web server: elucidating microRNA functions through target prediction.

PubMed

Maragkakis, M; Reczko, M; Simossis, V A; Alexiou, P; Papadopoulos, G L; Dalamagas, T; Giannopoulos, G; Goumas, G; Koukis, E; Kourtis, K; Vergoulis, T; Koziris, N; Sellis, T; Tsanakas, P; Hatzigeorgiou, A G

2009-07-01

Computational microRNA (miRNA) target prediction is one of the key means for deciphering the role of miRNAs in development and disease. Here, we present the DIANA-microT web server as the user interface to the DIANA-microT 3.0 miRNA target prediction algorithm. The web server provides extensive information for predicted miRNA:target gene interactions with a user-friendly interface, providing extensive connectivity to online biological resources. Target gene and miRNA functions may be elucidated through automated bibliographic searches and functional information is accessible through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The web server offers links to nomenclature, sequence and protein databases, and users are facilitated by being able to search for targeted genes using different nomenclatures or functional features, such as the genes possible involvement in biological pathways. The target prediction algorithm supports parameters calculated individually for each miRNA:target gene interaction and provides a signal-to-noise ratio and a precision score that helps in the evaluation of the significance of the predicted results. Using a set of miRNA targets recently identified through the pSILAC method, the performance of several computational target prediction programs was assessed. DIANA-microT 3.0 achieved there with 66% the highest ratio of correctly predicted targets over all predicted targets. The DIANA-microT web server is freely available at www.microrna.gr/microT.

DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.

PubMed

Vlachos, Ioannis S; Paraskevopoulou, Maria D; Karagkouni, Dimitra; Georgakilas, Georgios; Vergoulis, Thanasis; Kanellos, Ilias; Anastasopoulos, Ioannis-Laertis; Maniou, Sofia; Karathanou, Konstantina; Kalfakakou, Despina; Fevgas, Athanasios; Dalamagas, Theodore; Hatzigeorgiou, Artemis G

2015-01-01

microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation sequencing data sets. DIANA-TarBase was initially released in 2006 and it was the first database aiming to catalog published experimentally validated miRNA:gene interactions. DIANA-TarBase v7.0 (http://www.microrna.gr/tarbase) aims to provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users to easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments. More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database. DIANA-TarBase v7.0 is freely available. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Spatial distribution of marine fishes along a cross-shelf gradient containing a continuum of mangrove seagrass coral reefs off southwestern Puerto Rico

NASA Astrophysics Data System (ADS)

Aguilar-Perera, Alfonso; Appeldoorn, Richard S.

2008-01-01

Despite an extensive study of the fish community off southwestern Puerto Rico, little information is available on the fish spatial distribution along an inshore-offshore, cross-shelf gradient containing a continuum of mangrove-seagrass-coral reefs. We investigated the spatial distribution of reef-associated fish species using a stratified sampling procedure. A total of 52,138 fishes were recorded, representing 102 species belonging to 32 families. Significant differences in mean fish density were evident among strata. Mean densities at shallow fore reefs and deep fore reefs (Romero key) were significantly higher compared to the rest of strata along the gradient. Mean densities of fishes in mangroves and seagrass (Montalva Bay) were comparable to those at shallow back reefs and deep fore reefs offshore (Turrumote), but lower to those inshore (Romero); the lowest fish densities were found in mangroves and seagrass (Montalva Bay) and seagrass (Romero and Corral). At least 17 species, in 7 families, were among the most common in terms of relative abundance representing 76% of the total individuals sampled. A detrended correspondence analysis (DCA) applied to more abundant fish species showed a spatial pattern in density distribution. Three major groupings were evident corresponding to mangroves and seagrass (Montalva Bay), shallow and deep reefs (Romero), and shallow and deep reefs (Corral and Turrumote). A cluster analysis on mean fish densities of the more abundant species revealed a consistent spatial distribution according to biotope by separating the ichthyofauna associated with mangroves, seagrass and that of shallow (back and fore) reefs, and deep fore reefs.

Condolence Books: Language and Meaning in the Mourning for Hillsborough and Diana

ERIC Educational Resources Information Center

Brennan, Michael

2008-01-01

This article reports empirical research into public books of condolence signed following two key mourning events within British culture: the 1989 Hillsborough soccer stadium disaster and the death of Diana, Princess of Wales, in 1997. The author suggests that not only do condolence books provide valuable historical record of the way contemporary…

Using Controversy as a Teaching Tool: An Interview with Diana Hess

ERIC Educational Resources Information Center

Richardson, Joan

2018-01-01

In a time of hyperpolarization and hyper partisanship, preparing students to deliberate about their differences becomes even more important. In this interview, Diana Hess, dean of the School of Education at the University of Wisconsin-Madison and co-author of The Political Classroom, describes the challenge of ensuring that students have access to…

Cephenemyia stimulator and Hypoderma diana infection of roe deer in the Czech Republic over an 8-year period.

PubMed

Salaba, Ondrej; Vadlejch, Jaroslav; Petrtyl, Miloslav; Valek, Petr; Kudrnacova, Marie; Jankovska, Ivana; Bartak, Miroslav; Sulakova, Hana; Langrova, Iva

2013-04-01

A survey of naso-pharyngeal and subcutaneous myiasis affecting roe deer (Capreolus capreolus) was conducted in the Czech Republic over an 8-year period (1999-2006). A total of 503 bucks and 264 does from six hunting localities were examined. The sampling area comprised predominantly agricultural lowlands and a mountain range primarily covered by forest. Since 1997, the deer have been treated each winter across the board with ivermectin (150 mg/kg, CERMIX® pulvis, Biopharm, CZ). Parasites found were the larvae of Hypoderma diana and Cephenemyia stimulator. There were no significant differences in warble fly infection among captured animals in the individual hunting localities. Overall, 146 (28.8%) of 503 animals (bucks) were infected with Cephenemyia stimulator larvae; body size of the second instar larva reached 13-18 mm. The prevalence ranged from 16.1 to 42.9% per year, and the mean intensity from 6 to 11 larvae per animal. Additionally, a total of 264 roe deer (does) were examined for H. diana larvae, and 77 (29.1%) were found to be positive; body size of the second instar larva reached 17 mm. The prevalence ranged from 18.8 to 50.0% per year, and the mean intensity from 13 to 22 larvae per animal. The results showed that the bot flies, Cephenemyia stimulator as well as H. diana, are common parasites in roe deer in the Czech Republic, and that through the help of treatment (ivermectin), it is possible to keep parasite levels low. The body weights of infected and non-infected H. diana deer did not differ significantly.

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Jazz pianist and singer Diana Krall performs at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Diana Krall talked about her love of space flight and showed off her temporary tattoo that honors Canadian Astronaut Bob Thirsk who is currently onboard the International Space Station. Photo Credit: (NASA/Bill Ingalls)

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Jazz pianist and singer Diana Krall performs at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Diana Krall talked about her love of space flight and showed off her temporary tattoo that honors Canadian Astronaut Bob Thirsk who is currently onboard the International Space Station. Photo Credit: (NASA/Carla Cioffi)

"Deluded and Ruined": Diana Bastian--Enslaved African Canadian Teenager and White Male Privilege

ERIC Educational Resources Information Center

Cooper, Afua

2017-01-01

This essay explores the vulnerability of enslaved African Canadian Black women by examining the death of Diana Bastian, an enslaved Black teenager who in 1792 was raped by George More, a member of the Governing Council of Cape Breton, Nova Scotia. Though Bastian begged for assistance during the resultant pregnancy, More denied her such aid and…

Kinetics of thermophilic anaerobes in fixed-bed reactors.

PubMed

Perez, M; Romero, L I; Sales, D

2001-08-01

The main objective of this study is to estimate growth kinetic constants and the concentration of "active" attached biomass in two anaerobic thermophilic reactors which contain different initial sizes of immobilized anaerobic mixed cultures and decompose distillery wastewater. This paper studies the substrate decomposition in two lab-scale fixed-bed reactors operating at batch conditions with corrugated tubes as support media. It can be demonstrated that high micro-organisms-substrate ratios favor the degradation activity of the different anaerobic cultures, allowing the stable operation without lag-phases and giving better quality in effluent. The kinetic parameters obtained--maximum specific growth rates (mu(max)), non-biodegradable substrate (S(NB)) and "active or viable biomass" concentrations (X(V0))--were obtained by applying the Romero kinetic model [L.I. Romero, 1991. Desarrollo de un modelo matemático general para los procesos fermentativos, Cinética de la degradación anaerobia, Ph.D. Thesis, University of Cádiz (Spain), Serv. Pub. Univ. Cádiz], with COD as substrate and methane (CH4) as the main product of the anaerobic process. This method is suitable to calculate and to differentiate the main kinetic parameters of both the total anaerobic mixed culture and the methanogenic population. Comparison of experimental measured concentration of volatile attached solids (VS(att)) in both reactors with the estimated "active" biomass concentrations obtained by applying Romero kinetic model [L.I. Romero, 1991. Desarrollo de un modelo matemático general para los procesos fermentativos, Cinética de la degradación anaerobia, Ph.D. Thesis, University of Cádiz (Spain), Serv. Pub. Univ. Cádiz] shows that a large amount of inert matter is present in the fixed-bed reactor.

U-Pb age of the Diana Complex and Adirondack granulite petrogenesis

USGS Publications Warehouse

Basu, A.R.; Premo, W.R.

2001-01-01

U-Pb isotopic analyses of eight single and multi-grain zircon fractions separated from a syenite of the Diana Complex of the Adirondack Mountains do not define a single linear array, but a scatter along a chord that intersects the Concordia curve at 1145 ?? 29 and 285 ?? 204 Ma. For the most concordant analyses, the 207Pb/206Pb ages range between 1115 and 1150 Ma. Detailed petrographic studies revealed that most grains contained at least two phases of zircon growth, either primary magmatic cores enclosed by variable thickness of metamorphic overgrowths or magmatic portions enclosing presumably older xenocrystic zircon cores. The magmatic portions are characterized by typical dipyramidal prismatic zoning and numerous black inclusions that make them quite distinct from adjacent overgrowths or cores when observed in polarizing light microscopy and in back-scattered electron micrographs. Careful handpicking and analysis of the "best" magmatic grains, devoid of visible overgrowth of core material, produced two nearly concordant points that along with two of the multi-grain analyses yielded an upper-intercept age of 1118 ?? 2.8 Ma and a lower-intercept age of 251 ?? 13 Ma. The older age is interpreted as the crystallization age of the syenite and the younger one is consistent with late stage uplift of the Appalachian region. The 1118 Ma age for the Diana Complex, some 35 Ma younger than previously believed, is now approximately synchronous with the main Adirondack anorthosite intrusion, implying a cogenetic relationship among the various meta-igneous rocks of the Adirondacks. The retention of a high-temperature contact metamorphic aureole around Diana convincingly places the timing of Adirondack regional metamorphism as early as 1118 Ma. This result also implies that the sources of anomalous high-temperature during granulite metamorphism are the syn-metamorphic intrusions, such as the Diana Complex.

Process Waste Assessment for the Diana Laser Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, N.M.

1993-12-01

This Process Waste Assessment was conducted to evaluate the Diana Laser Laboratory, located in the Combustion Research Facility. It documents the hazardous chemical waste streams generated by the laser process and establishes a baseline for future waste minimization efforts. This Process Waste Assessment will be reevaluated in approximately 18 to 24 months, after enough time has passed to implement recommendations and to compare results with the baseline established in this assessment.

Minute gun series: Diana mist event. Project officers report (sanitized version). Summary report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schiff, A.T.; Tiano, D.E.

1971-12-27

Diana Mist was a Department of Defense underground nuclear test executed on 11 February 1970 in the n.06 drift of the U12n tunnel complex. Test chambers were located in an evacuated horizontal line-of-sight pipe at 400, 640, 755, 905, and 1110 feet from the nuclear source. The objectives of practically all other experiments were achieved through active measurements and/or posttest examination.

Laser systems for the combustion research facility - Diana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, C.K.; Lavasek, J.W.; Jones, E.D.

1982-03-01

A 5-Joule/pulse, 1.8-..mu..s-pulse-width, 10-ppS flashlamp-pumped tunable-dye-laser system, called Diana, has been built for use in experiments to be performed at the Combustion Research Facility, Sandia National Laboratories, Livermore. Design specifications for the system and details of construction are described, and it is noted that performance of the laser meets or exceeds all design criteria. Areas for further performance improvements are discussed, and updates are suggested to enhance system usefulness.

Tamarugite from Diana Cave (SW Romania) -first true karst occurrence

NASA Astrophysics Data System (ADS)

Pušcaš, C. M.; Onac, B. P.; Effenberger, H. S.; Povarǎ, I.

2012-04-01

Diana Cave is located within the town limits of Baile Herculane (SW Romania) and develops as a 14 m long, westward oriented, unique passage guided by the Diana fault [1]. At the far end of the cave, the thermo-mineral Diana Spring wells forth. In the early 1970s a mine gallery that intersected the cave was created to drain the water into a pumping station and the original cave passage was somewhat altered and reinforced with concrete. Today the concrete and the silty limestone cave walls are heavily corroded by H2SO4 outgassing from the hot water (ca. 50°C) and display abundant gypsum crusts, soggy aggregates of native S, and a variety of more exotic sulfates. Among them, a mineral that has been previously identified in caves only in connection to volcanic activity, either as thermal springs or fumaroles [2]: tamarugite [NaAl(SO4)26H2O]. It was [3] that first mentioned the occurrence of this Na and Al sulfate in Diana Cave, our research aiming to give a detailed description of this mineral, its paragenesis, and mechanisms of precipitation. Recently, tamarugite has also been identified in a sulfuric acid cave from Greece [4]. Along with powder X-ray diffractions coupled with Rietveld refinement, scanning electron microscope, and electron probe micro-analysis, δ18O and δ34S compositions of the sulfate mineral as well as precipitates from the water were analyzed to identify and better constrain the genesis of this rare sulfate. Regrettably, the crystal size of our specimens is inappropriate for identification by means of single crystal X-ray diffraction. Physical and chemical parameters of Diana Spring were as well measured on several occasions. Geochemical analysis suggests that the minute, white tamarugite flakes precipitated in Diana Cave as a result of the interactions between the thermo-mineral water or water vapor and the original limestone bedrock and concrete that blankets the mine gallery. [1] Povara, I., Diaconu, G., Goran, C. (1972). Observations préliminaires sur les grottes influencées par les eaux thermo-minérales de la zone Baile-Herculane. Trav. Inst. Speol. "Emile Racovitza", XI, 355-365. [2] Rodgers, K.A., Hamlin, K.A., Browne, P.R.L., Campbell, K.A., Martin, R. (2000). The steam condensate alteration mineralogy of Ruatapu cave, Orakei Korako geothermal field, Taupo Volcanic Zone, New Zealand. Mineralogical magazine, 64(1), 125-142. [3] Onac, B.P., Sumrall, J., Tama?¸ T., Povara, I., Kerns, J., Dârmiceanu, V., Vere?¸ D., Lascu, C. (2009). The relationship between cave minerals and H2S-rich thermal waters along the Cerna Valley (SW Romania). Acta Carsologica, 38(1), 27-39. [4] Lazaridis G, Melfos, V, Papadopoulou L (2011). The first cave occurrence of orpiment (As2S3) from the sulfuric acid caves of Aghia Paraskevi (Kassandra Peninsula, N. Greece). International Journal of Speleology, 40(2): 133-139.

Geologic Map of the Diana Chasma Quadrangle (V-37), Venus

USGS Publications Warehouse

Hansen, V.L.; DeShon, H.R.

2002-01-01

Diana Chasma quadrangle hosts some of the steepest topography on Venus. Altimetry measurements range from -2.5 to 4.7 km (0.0 = mean planetary radius), with a surface mean of 0.6 km. Fractures and faults within the central fracture/rift zone create large blocks of down-dropped material, especially along the east-central edge of the map area. The Dali and Diana chasmata display slopes of >30°, the steepest and deepest trenches on Venus. Both chasmata host landslide deposits presumably sourced from the steep chasmata walls. The tessera inlier, coronae, and ridge belts sit topographically above Rusalka and Zhibek planitiae. Rusalka Planitia topography describes broad undulations having northwest-trending ridges spaced ~200 km apart. The most distinctive ridge, Vetsorgo Dorsum, centered at 6.5° S., 163° E., is a Class I ridge belt owing to its simple arch morphology. The central interior of Markham crater sits topographically lower than the surrounding region, which slopes downward to the east.

Sofia Ionescu, the first woman neurosurgeon in the world.

PubMed

Ciurea, Alexandru-Vlad; Moisa, Horatiu Alexandru; Mohan, Dumitru

2013-11-01

The authors present the activity of Mrs. Sofia Ionescu, the one female surgeon who was nominated as the first woman neurosurgeon in the world. Sofia Ionescu worked in the field of neurosurgery for 47 years, performing all the known neurosurgical procedures of the time. She made herself known through her incredible surgical skill and her enormous work power. Due to her incredible modesty and workload, she never participated at international congresses or manifestations. The nomination as first woman neurosurgery took place in Marrakech, Morocco, during the 2005 WFNS Congress. Although some claim that Diana Beck was the first woman neurosurgeon in the world, our theory suggests otherwise. The first documented surgical intervention performed by Diana Beck dates to 1952. Sofia Ionescu operated for the first time on a human brain as early as 1944. Furthermore, Diana Beck's actions surfaced in the year 1947, long after the war had ended and Sofia Ionescu had become a neurosurgeon. Copyright © 2013. Published by Elsevier Inc.

Badlands: Regolith, Forms and Processes. A review of the scientific research in Spain

NASA Astrophysics Data System (ADS)

Nadal-Romero, Estela; Cerdà, Artemi

2014-05-01

Badlands are usually defined as 'intensely dissected natural landscapes where vegetation is sparse or absent and which are useless for agriculture' (Bryan and Yair, 1982). Badlands are widerspread around the world (Nadal-Romero, 2007; Dickie and Parsons, 2012; Haregeweyn et al., 2012). In Spain due to the climatic and geological conditions badlands are widespread. Badlands research has national and foreign pioneers (Harvey, 1982; Clotet et al., 1988; Alexander and Calvo, 1990; Calvo et al., 1991; Alexander et al., 1994). Almería, Granada, Murcia, Alicante, the Ebro Valley, and the Pyrenees are good examples of the variety and diversity of badlands in Spain (García-Ruiz and López-Bermúdez, 2009). The research on badlands paid attention to the infiltration and runoff generation (Cerdà, 1999a), piping (Romero-Diaz et al., 2011), the role of parent material on the regolith morphology (Regués, 1995; Cerdà, 1998b) and the soil development (Regués, 1993), and the interaction of the vegetation and soil erosion (Cerdà and García Fayos, 1997; Solé et al., 1997) vegetation varied, whereas the percentage of studies on erosion rates increased steadily over time. During the 90s badlands research was flowering and research on badlands developments, forms and soil physical properties influence was done. The 00's were a period with research focused on processes (infiltration, runoff and erosion) but in general the interest on badland decreased. However, badlands are intensively researched in the Ebro Valley (Nadal-Romero et al., 2007; 2008; Nadal-Romero and Regués; 2009; 2010) and new research is being developed on degraded soils following the knowledge found on badlands (Cerdà, 2007; García Fayos et al., 2010). The future is moving to study vegetation dynamics and badlands reclamation, the effect of climatic change in badland areas, and erosion processes and rates (Nadal-Romero et al., 2013). The use of new non-invasive technologies (remote sensing, Terrestrial Laser Scanner, photogrammetry) helps to develop new research scenarios. Acknowledgements The research projects GL2008-02879/BTE, LEDDRA 243857 and RECARE FP7 project 603498supported this research. References Alexander, RW., Calvo, A. 1990. The influence of lichens on slope processes in some Spanish badlands. In: Vegetation and erosion. Processes and environments (Thorne, J.B., eds.). John Wiley & Sons, Chichester, pp. 385-398. Alexander, RW., Harvey, AM., Calvo, A., James, PA., Cerdà, A. 1994. Natural stabilization mechanisms on badland slopes: Tabernas, Almería, Spain. In: Environmental change in drylands: Biogeographical and geomorphological perspectives (Millington, C., Pye, K., eds.). Wiley, Chichester, pp. 85-111. Bryan, RB., Yair, A. 1982. Badland Geomorphology and piping. GeoBooks, Norwich, pp. 408. Calvo, A., Harvey, AM., Paya, J., Alexander, R. 1991. A response of badland surfaces in south east Spain to simulated rainfall. Cuaternario y Geomorfología, 5: 3-14. Cerdà, A., García-Fayos, P.1997. The influence of slope angle on sediment, water and seed losses on badland landscapes. Geomorphology, 18, 77-90. Cerdà, A. 1999a. Seasonal and spatial variations in infiltration rates in badland surfaces under Mediterranean climatic conditions. Water Resources Research, 35 (1) 319-328. Cerdà, A. 1999b. Parent material and vegetation affect soil erosion in eastern Spain. Soil Science Society of America Journal, 63, 362-368. Cerdà, A. 2007. Soil water erosion on road enbankments in eastern Spain. Science of the Total Environment, 378, 151-155. Clotet, N., Gallart, F., Balasch, J. 1988. Medium term erosion rates in a small scarcely vegetated catchment in the Pyrenees. Catena Supplement, 13: 37-47. Desir, G., Marin, C. 2007. Factors controlling the erosion rates on a semiarid zone (Bardenas Reales, NE Spain). Catena, 71, 31-44. García-Fayos, P., Bochet, E., Cerdà, A. 2010. Seed removal susceptibility through soil erosion shapes vegetation composition. Plant and Soil 334: 289-297. García-Ruiz, JM., López-Bermúdez, F. 2009. La erosión del suelo en España. Sociedad Española de Geomorfología, Zaragoza, pp. 441. Haregeweyn, N., Poesen, J., Verstraeten, G., Govers, G., de Vente, J., Nyssen, J., Deckers, J., Moeyersons, J. 2013. Assessing the performance of a Spatially distributed soil erosion and sediment delivery model (WATEM/SEDEM) in Northern Ethiopia. Land Degradation & Development 24, 188-204. DOI 10.1002/ldr.1121 Harvey, A. 1982. The role of piping in the development of badlands and gully systems in southeast Spain. In: Badland geomorphology and piping (Bryan, RB., Yair, A., eds.). GeoBooks, Norwich, pp. 317-336. Nadal Romero, E. Regüés, D. Martí-Bono, C. Serrano-Muela, P., 2007. Badland dynamics in the Central Pyrenees: temporal and spatial patterns of weathering processes. Earth Surface Processes and Landforms, 32, 888-904. Nadal Romero, E., Latron, J., Lana-Renault, N., Serrano-Muela, P., Martí-Bono, C., Regüés, D. 2008. Temporal variability in hydrological response within a small catchment with badland areas, Central Pyrenees. Hydrological Science Journal, 53, 629-639. Nadal-Romero, E., Torri, D., Yair, A. 2013. Updating the badlands experience. Catena, 106: 1-3. Nadal Romero, E., Regüés, D. 2009. Detachment and infiltration variations as consequence of regolith development in a Pyrenean badland system. Earth Surface Processes and Landforms, 34 (6): 824-838. Nadal Romero, E., Regüés, D. 2010. Geomorphological dynamics of subhumid mountain badland areas - weathering, hydrological and suspended sediment transport processes: A case study in the Araguas catchment (Central Pyrenees) and implications for altered hydroclimatic regimes. Progress in Physical Geography 34 (2): 123-150. Regüés D., Llorens P., Pardini G., Pini R., Gallart F. 1993. Physical weathering and regolith behaviour in a high erosion rate badland area at the Pyrenees: research design and first results. Pirineos, 141-142, 63-8. Regüés D., Pardini G., Gallart F. 1995. Regolith behaviour and physical weathering of clayey mudrock as dependent on seasonal weather conditions in a badland area at Vallcebre, Eastern Pyrenees. Catena, 25, 199-212. Romero Díaz, A., Alonso Sarria, F., Sánchez Soriano. A. 2011. Influencia de los factores topográficos en los procesos de piping, Murcia (España). Cuadernos de Investigación Geográfica, 37, 41-66. Solé, A., Calvo, A., Cerdà, A., Lázaro, R., Pini, R. & Barbero, J. 1997. Influences of micro-relief patterns and plant cover on runoff related processes in badlands from Tabernas (SE Spain). Catena, 31, 23-38.

Enterovirus D68

MedlinePlus

Non-polio enterovirus ... Centers for Disease Control and Prevention website. Enterovirus D68. www.cdc.gov/non-polio-enterovirus/about/ev-d68.html#us . Updated October 20, 2017. Accessed October 26, 2017. Romero JR, Modlin ...

10. June 25, 1963 SEED BUILDING UNDER CONSTRUCTION Looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. June 25, 1963 SEED BUILDING UNDER CONSTRUCTION Looking northeast showing west wall of Machinery Shed - Tucson Plant Material Center, Machinery Shed, 3241 North Romero Road, Tucson, Pima County, AZ

Diana Reference Manual. Revision 3,

DTIC Science & Technology

1983-02-28

will help the reader to understand DIANA. Section 1. 1. 1 presents those principles that motivated the original design of DIAN. and Section 1. 1. 2...parenthesized node whose offspring was the addition, since ADA’s parsing rules require the parentheses. The motivation for this requirement Is to ease the...3.7. a 41neA~olm S3.I. C, S.1. F] 51. 52 number 3.1, 3.2.8] 33, 33 numw_d [3.2.83e 35 number rep C4.4.0] 43 nummicUteral [4:4.0] 43 ps4 . I.A 46

4. MACHINERY SHED AND STORAGE ROOM ADDITION, SOUTH AND WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. MACHINERY SHED AND STORAGE ROOM ADDITION, SOUTH AND WEST WALL LOOKING NORTHEAST SEED STORAGE BUILDING (1963) BEHIND - Tucson Plant Material Center, Machinery Shed, 3241 North Romero Road, Tucson, Pima County, AZ

Tamarugite in the Steam-Condensate Alteration Paragenesis in Diana Cave (SW Romania)

NASA Astrophysics Data System (ADS)

Puscas, C. M.; Onac, B. P.; Effenberger, H. S.; Povară, I.

2012-12-01

The double-salt hydrate tamarugite [NaAl(SO4)2 6H2O] is an uncommon mineral in the cave environment, forming as a result of chemical reactions between water and bedrock only under very specific conditions. The Diana Cave hosts a unique tamarugite occurrence, the first one to be reported from a typical karst environment. The cave is located within the limits of Băile Herculane township in the Cerna Mountains, SW Romania. It consists of a 14 m long, westward-oriented single passage, developed along the Diana Fault. In 1974 a concrete-clad mine gallery was created to channel the thermal water (Diana 1+2 Spring) flowing through the cave to a pumping station. The spring's chemical and physical parameters fluctuated through time, averaging 51.98° C, discharge of 0.96 Ls-1, pH of 7.46, 5768.66 ppm TDS, 9303 μScm-1 conductivity, 5.02 salinity. The major chemical components of the thermo-mineral water in Diana Cave are, Na+ (1392.57 ppm), K+ (58.55 ppm), Ca2+ (725.16 ppm), Mg2+ (10.78 ppm), Cl- (3376.83 ppm), and SO42- (92.27 ppm), and H2S (24.05 ppm), with traces of Si, Fe2+, Br+, I-, and Li+. The general air circulation pattern within the cave is fairly simple: cold air from the outside sweeps into the cave along the floor, heats up at the contact with the thermo-mineral water, ascends, and exists the cave along the ceiling. At the contact with the cold walls of the Diana Cave, the hot steam condenses and gives rise to a rich and exotic sulfate-mineral paragenesis (including halotrichite-series minerals, gypsum, bassanite, anhydrite, epsomite, alunite, halite, native sulfur, etc.). The most exotic minerals precipitate at or below the contact between the Tithonic - Neocomian limestone and the overlaying Cretaceous shaly limestone, as a result of steam-condensate alteration. Minerogenetic mechanisms responsible for the peculiar sulfate mineral assemblage in Diana Cave are evaporation, oxidation, hydrolysis, double exchange reactions, and deposition from vapours or possibly aerosols. This highly aggressive alteration of the carbonate rock (known as sulfuric acid speleogenesis) extends from the ceiling of the cave downward to, or slightly below, the water table and is responsible for further enlargement of cave passages. Given the availability of SO42-, gypsum replacement crusts form in the subaerial part of the cave, as well as thin gypsum rafts at the water surface. The presence of tamarugite indicates sufficiently strong acid conditions in the steam-condensate film to dissolve clay minerals, releasing Na+ and Al3+ into the geochemical system. Conditions conducive to tamarugite precipitation in carbonate caves seem to be the presence of: 1) thermo-mineral water, which through surface evaporation and condensation on the cold cave walls causes steam-condensate alteration processes, 2) sulfuric acid, and 3) a constant source of Al3+ and Na+. Such conditions are seldom fulfilled in any ordinary limestone caves. The bedrock geology and the particular tectonics and hydrogeology of the Băile Herculane area seem to be the essential prerequisites, not only for the development of hypogene karst, but also for producing an outstanding cave mineral assemblage.

Application of hybrid clustering using parallel k-means algorithm and DIANA algorithm

NASA Astrophysics Data System (ADS)

Umam, Khoirul; Bustamam, Alhadi; Lestari, Dian

2017-03-01

DNA is one of the carrier of genetic information of living organisms. Encoding, sequencing, and clustering DNA sequences has become the key jobs and routine in the world of molecular biology, in particular on bioinformatics application. There are two type of clustering, hierarchical clustering and partitioning clustering. In this paper, we combined two type clustering i.e. K-Means (partitioning clustering) and DIANA (hierarchical clustering), therefore it called Hybrid clustering. Application of hybrid clustering using Parallel K-Means algorithm and DIANA algorithm used to clustering DNA sequences of Human Papillomavirus (HPV). The clustering process is started with Collecting DNA sequences of HPV are obtained from NCBI (National Centre for Biotechnology Information), then performing characteristics extraction of DNA sequences. The characteristics extraction result is store in a matrix form, then normalize this matrix using Min-Max normalization and calculate genetic distance using Euclidian Distance. Furthermore, the hybrid clustering is applied by using implementation of Parallel K-Means algorithm and DIANA algorithm. The aim of using Hybrid Clustering is to obtain better clusters result. For validating the resulted clusters, to get optimum number of clusters, we use Davies-Bouldin Index (DBI). In this study, the result of implementation of Parallel K-Means clustering is data clustered become 5 clusters with minimal IDB value is 0.8741, and Hybrid Clustering clustered data become 13 sub-clusters with minimal IDB values = 0.8216, 0.6845, 0.3331, 0.1994 and 0.3952. The IDB value of hybrid clustering less than IBD value of Parallel K-Means clustering only that perform at 1ts stage. Its means clustering using Hybrid Clustering have the better result to clustered DNA sequence of HPV than perform parallel K-Means Clustering only.

9. May 20, 1963 SEED BUILDING FOUNDATION WALLS Under Construction. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. May 20, 1963 SEED BUILDING FOUNDATION WALLS Under Construction. Looking southeast showing north and west walls of Machinery Shed - Tucson Plant Material Center, Machinery Shed, 3241 North Romero Road, Tucson, Pima County, AZ

Genetics Home Reference: SATB2-associated syndrome

MedlinePlus

... factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell- ... Citation on PubMed or Free article on PubMed Central Britanova O, de Juan Romero C, Cheung A, ...

"The black and white of it": Barbara Grier editing and publishing women of color.

PubMed

Enszer, Julie R

2014-01-01

In the 1970s and 1980s, lesbian-feminist writing and publishing expressed new theoretical insights about race and envisioned new, intersectional identities. Using texts published and edited by Grier in The Ladder and subsequent Ladder anthologies published by Diana Press, archival documents from Diana Press, and the Grier-Naiad Press papers, this article explores Grier's editorial practices and compares Grier's work to other lesbian-feminist editors and publishers to illuminate different generational understandings of racial-ethnic and class formations within lesbianism and feminism and highlight some of the strategies that White publishers like Grier utilized to realize a vision of multicultural publishing.

Lesbian (in)visibility in Italian Renaissance culture: Diana and other cases of donna con donna.

PubMed

Simons, P

1994-01-01

Current conceptualizations of sexual identity in the West are not necessarily useful to an historian investigating "lesbianism" in the social history and visual representations of different periods. After an overview of Renaissance documents treating donna con donna relations which examines the potentially positive effects of condemnation and silence, the paper focuses on Diana, the goddess of chastity, who bathed with her nymphs as an exemplar of female bodies preserved for heterosexual, reproductive pleasures. Yet the self-sufficiency and bodily contact sometimes represented in images of this secluded all-female gathering might suggest "deviant" responses from their viewers.

"Sir insulin monk versus the evil Diana betes": a program addressing type 2 diabetes education and prevention in youth.

PubMed

Fenn, Jeanne; Rosales, Cecilia; Logue, Claire

2007-01-01

The purpose of this article is to share an innovative method of integrating community resources into a program designed to deliver age-appropriate and culturally appropriate diabetes education to youth. The educational program involves an interactive dialogue that engages school-aged children in an active process of learning about diabetes. School or community-based settings provide the best venue for presenting information to youth on diabetes. In addition, peer education is an excellent method of creating interest among youth. Many adults have received diabetes education simply by observing the program. This program has become an appealing and interactive method of delivering type 2 diabetes prevention information to children of all ages.

Policy. IDRA Focus.

ERIC Educational Resources Information Center

IDRA Newsletter, 1997

1997-01-01

This newsletter includes five articles about educational and school policies, primarily related to equality of educational opportunity. "Texas Legislature Considers Much for Education, Accomplishes Little" (Albert Cortez, Anna Alicia Romero) summarizes educational legislation considered by the Texas legislature in the session ending in…

78 FR 68019 - Performance Review Board Appointments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

....; Chasteen, G. Taylor; Christian, Lisa A.; Clanton, Michael W.; Coffee, Richard; Cook, Cheryl L.; Davenport....; Paul, Matt; Pfaeffle, Frederick; Pino, Lisa; Repass, Todd; Robinson, Quinton; Romero, Ramona; Ruiz..., Lisa; Wright, Ann; Young, Benjamin; Young, Mike; Zehren, Christopher J. Marketing and Regulatory...

[Anesthesiological systems "Polinarkon-Vita" with microprocessor for artificial lung ventilation apparatuses and monitoring].

PubMed

Trushin, A I; Uliakov, G I; Reĭderman, E N

2005-01-01

The anesthesiological systems Polinarkon-Vita for adults and children are described. These systems were developed at VNIIMP-VITA, Ltd. on the basis of basic model of the anesthesiological system Polinarkon-E-Vita. The following new important units of the fifth generation apparatuses for inhalation anesthesia (IA) are described: Anestezist-4 monocomponent evaporator for liquid anesthetics (enfluran and isofluran); Diana, Diana-Det, and Elan-NR apparatuses for mechanical lung ventilation (MLV); dosimeters of medical gases, etc. These systems implement monitoring of vitally important functions of patient and parameters of IN and MLV. The anesthesiological systems Polinarkon-Vita are recommended for medical practice and commercially available from VNIIMP-VITA, Ltd. as small lots.

DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

PubMed

Bonfill, Xavier; Osorio, Dimelza; Solà, Ivan; Pijoan, Jose Ignacio; Balasso, Valentina; Quintana, Maria Jesús; Puig, Teresa; Bolibar, Ignasi; Urrútia, Gerard; Zamora, Javier; Emparanza, José Ignacio; Gómez de la Cámara, Agustín; Ferreira-González, Ignacio

2016-01-01

To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database. Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own. We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability. Future efforts should be focused on assessing the impact of these appraisals in the clinical practice.

DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis

PubMed Central

Bonfill, Xavier; Osorio, Dimelza; Solà, Ivan; Pijoan, Jose Ignacio; Balasso, Valentina; Quintana, Maria Jesús; Puig, Teresa; Bolibar, Ignasi; Urrútia, Gerard; Zamora, Javier; Emparanza, José Ignacio; Gómez de la Cámara, Agustín; Ferreira-González, Ignacio

2016-01-01

Objective To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database. Methods and Findings Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own. Conclusions We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability. Future efforts should be focused on assessing the impact of these appraisals in the clinical practice. PMID:26840451

A Beautiful Britto Still Life

ERIC Educational Resources Information Center

Coy, Mary

2012-01-01

Romero Britto is a wonderful artist for young students to study when learning the building blocks of art and design. Colorful, linear, and full of bold patterns, Britto's work blends a contemporary cubist style and pop art commercial appeal. Themes of this contemporary artist's work include animals, flowers, still life, and people in joyful…

Planting the Seeds: Frontiers of Justice.

ERIC Educational Resources Information Center

Mischler-Philbin, Jim; Murphy, Katie (with an introduction by Eileen Emerson)

2000-01-01

Contains articles written by two former Frontiers of Justice participants about their experiences and reflections on the legacy message of the Church in El Salvador. Also includes a poem written by the Archbishop Oscar Romero, and an extensive bibliography of resources in English on the Church in El Salvador. (VWC)

First detection of Echinococcus multilocularis infection in two species of nonhuman primates raised in a zoo: a fatal case in Cercopithecus diana and a strongly suspected case of spontaneous recovery in Macaca nigra.

PubMed

Yamano, Kimiaki; Kouguchi, Hirokazu; Uraguchi, Kohji; Mukai, Takeshi; Shibata, Chikako; Yamamoto, Hideaki; Takaesu, Noboru; Ito, Masaki; Makino, Yoshinori; Takiguchi, Mitsuyoshi; Yagi, Kinpei

2014-08-01

The causative parasite of alveolar echinococcosis, Echinococcus multilocularis, maintains its life cycle between red foxes (Vulpes vulples, the definitive hosts) and voles (the intermediate hosts) in Hokkaido, Japan. Primates, including humans, and some other mammal species can be infected by the accidental ingestion of eggs in the feces of red foxes. In August 2011, a 6-year-old zoo-raised female Diana monkey (Cercopithecus diana) died from alveolar echinococcosis. E. multilocularis infection was confirmed by histopathological examination and detection of the E. multilocularis DNA by polymerase chain reaction (PCR). A field survey in the zoo showed that fox intrusion was common, and serodiagnosis of various nonhuman primates using western blotting detected a case of a 14-year-old female Celebes crested macaque (Macaca nigra) that was weakly positive for E. multilocularis. Computed tomography revealed only one small calcified lesion (approximately 8mm) in the macaque's liver, and both western blotting and enzyme-linked immunosorbent assay (ELISA) showed a gradual decline of antibody titer. These findings strongly suggest that the animal had recovered spontaneously. Until this study, spontaneous recovery from E. multilocularis infection in a nonhuman primate had never been reported. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

John Simon | NREL

Science.gov Websites

novel crystalline substrates for growth of III-V Nitride semiconductors for solid-state lighting applications. Since then he has been involved in various projects involving the growth of III-V semiconductor .; Romero, M.; and Lee, M.J. "Metamorphic GaAsP buffers for growth of wide-bandgap InGaP solar cells

Improving School Attendance through Collaboration: A Catalyst for Community Involvement and Change

ERIC Educational Resources Information Center

Childs, Joshua; Grooms, Ain A.

2018-01-01

Chronic absenteeism is often referred to as a problem hidden in plain sight (Chang & Romero, 2008). In recent years, more communities around the United States have been intentional on improving student attendance and limiting the impact of chronic absenteeism. Using qualitative interviews, we sought to understand how one community was…

Dynamical Analysis of the Boundary Layer and Surface Wind Responses to Mesoscale SST Perturbations

DTIC Science & Technology

2010-02-01

latitude (e.g., Gille and Romero 2003; Lumpkin and Pazos 2007). We thus expect that inclusion of ocean current effects in the surface stress computations...Niiler, 2007: Ocean–atmosphere interaction over Agulhas Extension meanders. J. Climate, 20, 5784–5797. Lumpkin, R., and M. Pazos , 2007: Measuring surface

78 FR 76399 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

... Charles A. Adams, Jr. (CT), Thomas W. Allee (WI), J.D. Ashcraft, Jr. (AL), Robert J. Berger III (PA). Michael E. Bingham (WA), Danny W. Bradley (DE), Richard A. Clark (GA), Winfred G. Clemenson (WA), Romero...), Carolyn C. Gardner (CT), Brian L. Gregory (IL), Alfonso Grijalva (CA), Jason E. Jacobus (KY), Ervin A...

Issues of Class and Culture in Today's Community Colleges.

ERIC Educational Resources Information Center

Rendon, Laura I.

New researchers on community colleges, such as Rob Rhoads, Estela Bensimon, Bill Tierney, James Valadez, Berta Laden, and Romero Jalomo, are exploring new conceptual frameworks to guide thinking about the transformation of community colleges from mere open-access institutions into colleges that make a difference in the lives of students who have…

Romero Britto Stopped by Our Art Room

ERIC Educational Resources Information Center

Knappenberger, Jenny

2012-01-01

Art teachers often get stuck teaching students about "classical" artists who lived over 500 years ago. As art enthusiasts, teachers may be very interested in their importance, but children might be wondering why they have to learn about yet another dead artist. In this article, the author describes how her eighth-grade art students created their…

Race and Ethnicity in Empirical Research: An 18-Year Review

ERIC Educational Resources Information Center

Shelton, Kimber L.; Delgado-Romero, Edward A.; Wells, Eliza M.

2009-01-01

Extending previous research (E. A. Delgado-Romero, N. Galvan, P. Maschino, & M. Rowland, 2005) regarding race and ethnicity in counseling and counseling psychology, this article examined how race and ethnicity were reported and used in empirical studies published in diversity-focused journals from 1990 to 2007. The results are discussed and…

DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts

PubMed Central

Paraskevopoulou, Maria D.; Vlachos, Ioannis S.; Karagkouni, Dimitra; Georgakilas, Georgios; Kanellos, Ilias; Vergoulis, Thanasis; Zagganas, Konstantinos; Tsanakas, Panayiotis; Floros, Evangelos; Dalamagas, Theodore; Hatzigeorgiou, Artemis G.

2016-01-01

microRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like function of lncRNAs introduces an extra layer of complexity in the miRNA interactome. DIANA-LncBase v1 provided a database of experimentally supported and in silico predicted miRNA Recognition Elements (MREs) on lncRNAs. The second version of LncBase (www.microrna.gr/LncBase) presents an extensive collection of miRNA:lncRNA interactions. The significantly enhanced database includes more than 70 000 low and high-throughput, (in)direct miRNA:lncRNA experimentally supported interactions, derived from manually curated publications and the analysis of 153 AGO CLIP-Seq libraries. The new experimental module presents a 14-fold increase compared to the previous release. LncBase v2 hosts in silico predicted miRNA targets on lncRNAs, identified with the DIANA-microT algorithm. The relevant module provides millions of predicted miRNA binding sites, accompanied with detailed metadata and MRE conservation metrics. LncBase v2 caters information regarding cell type specific miRNA:lncRNA regulation and enables users to easily identify interactions in 66 different cell types, spanning 36 tissues for human and mouse. Database entries are also supported by accurate lncRNA expression information, derived from the analysis of more than 6 billion RNA-Seq reads. PMID:26612864

Global Self-Worth in Latino Youth: The Role of Acculturation and Acculturation Risk Factors

ERIC Educational Resources Information Center

Kapke, Theresa L.; Gerdes, Alyson C.; Lawton, Kathryn E.

2017-01-01

Background: Despite Latino youth being at increased risk of developing mental health problems, they are less likely to receive adequate treatment (Gonzales et al. in "Handbook of U.S. Latino psychology: developmental and community-based perspectives." Sage, Thousand Oaks, pp 115-134, 2009; Romero et al. in "Ethn Health"…

27. AERIAL VIEW OF ARVFS FIELD TEST SITE AS IT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. AERIAL VIEW OF ARVFS FIELD TEST SITE AS IT LOOKED IN 1983. OBLIQUE VIEW FACING EAST. BUNKER IS IN FOREGROUND, PROTECTIVE SHED FOR WFRP AT TOP OF IMAGE. INEL PHOTO NUMBER 83-574-12-1, TAKEN IN 1983. PHOTOGRAPHER: ROMERO. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

shinyCircos: an R/Shiny application for interactive creation of Circos plot.

PubMed

Yu, Yiming; Ouyang, Yidan; Yao, Wen

2018-04-01

Creation of Circos plot is one of the most efficient approaches to visualize genomic data. However, the installation and use of existing tools to make Circos plot are challenging for users lacking of coding experiences. To address this issue, we developed an R/Shiny application shinyCircos, a graphical user interface for interactive creation of Circos plot. shinyCircos can be easily installed either on computers for personal use or on local or public servers to provide online use to the community. Furthermore, various types of Circos plots could be easily generated and decorated with simple mouse-click. shinyCircos and its manual are freely available at https://github.com/venyao/shinyCircos. shinyCircos is deployed at https://yimingyu.shinyapps.io/shinycircos/ and http://shinycircos.ncpgr.cn/ for online use. diana1983941@mail.hzau.edu.cn or yaowen@henau.edu.cn.

Autonomy and autonomy competencies: a practical and relational approach.

PubMed

Atkins, Kim

2006-10-01

This essay will address a general philosophical concern about autonomy, namely, that a conception of autonomy focused on freedom of the will alone is inadequate, once we consider the effects of oppressive forms of socialization on individuals' formation of choices. In response to this problem, I will present a brief overview of Diana Meyers's account of autonomy as relational and practical. On this view, autonomy consists in a set of socially acquired practical competencies in self-discovery, self-definition, self-knowledge, and self-direction. This account provides a distinction between choices that express unreflectively internalized social norms and those that are the result of a critical 'self-reading'. I conclude that this practical conception of autonomy makes much higher demands upon nurses (and patients) than has previously been thought. In fact, if nurses are to be expected to genuinely promote autonomy, they are going to need specific training in counselling-type communication skills.

Application of PIXE to the study of Renaissance style enamelled gold jewelry

NASA Astrophysics Data System (ADS)

Weldon, M.; Carlson, J.; Reedy, S.; Swann, C. P.

1996-04-01

This study examines and compares three pieces of Renaissance style gold and enamelled jewelry owned by the Walters Art Gallery, Baltimore, MD, USA. These are a 16th century Hat Badge of Adam and Eve, a 19th century Fortitude Pendant and a Diana Pendant presumed to be of the 16th century (The Walters Art Gallery, Jewelry, Ancient to Modern (Viking, New York, 1979)), Ref. [1]. PIXE spectroscopy was applied to examine the elemental composition of the gold and of the enamels. Compositional differences, including the use of post-Renaissance colorants, were found between the enamels in separate regions of each of the three pieces. The modern colorant, chromium, was, in fact, found in all of the pieces and uranium was found in only the Diana Pendant. There are some differences in the gold purity of the three objects; there are significant differences in the solders used even within one object, the Fortitude Pendant.

Modelling soil organic carbon stocks along topographic transects under climate change scenarios using CarboSOIL

NASA Astrophysics Data System (ADS)

Kotb Abd-Elmabod, Sameh; Muñoz-Rojas, Miriam; Jordán, Antonio; Anaya-Romero, María; de la Rosa, Diego

2014-05-01

CarboSOIL is a land evaluation model for soil organic carbon (SOC) accounting under global change scenarios (Muñoz-Rojas et al., 2013a; 2013b) and is a new component of the MicroLEIS Decision Support System. MicroLEIS is a tool for decision-makers dealing with specific agro-ecological problems as, for example, soil contamination risks (Abd-Elmabod et al., 2010; Abd-Elmabod et al., 2012)which has been designed as a knowledge-based approach incorporating a set of interlinked data bases. Global change and land use changes in recent decades have caused relevant impacts in vegetation carbon stocks (Muñoz-Rojas et al., 2011) and soil organic carbon stocks, especially in sensible areas as the Mediterranean region (Muñoz-Rojas et al., 2012a; 2012b). This study aims to investigate the influence of topography, climate, land use and soil factors on SOC stocks by the application of CarboSOIL in a representative area of the Mediterranean region (Seville, Spain). Two topographic transects (S-N and W-E oriented) were considered, including 63 points separated 4 km each. These points are associated to 41 soil profiles extracted from the SDBm soil data base (De la Rosa et al., 2001) and climatic information (average minimum temperature, average maximum temperature and average rainfall per month) extracted from raster data bases (Andalusian Environmental Information Network, REDIAM). CarboSOIL has been applied along topographic transects at different soil depths and under different climate change scenarios. Climate scenarios have been calculated according to the global climate model (CNRMCM3) by extracting spatial climate data under IPCC A1B scenario for the current period (average data from 1960-2000), 2040, 2070 and 2100. In the current scenario, results show that the highest SOC stock values located on Typic Haploxeralfs under olive groves for soil sections 0-25 cm and for 25-50 cm, but the highest values were determined on fruit-cropped Rendolic Xerothent in the 50-75cm section. On the other hand, lowest SOC stock values have been observed on sections 0-25 and 25-50 cm from Aquic Haploxeralf under wheat, cotton and other annual crops and vineyards, respectively. The lowest SOC values were determined in section 50-75 cm from Typic Ochraqualfs under olive groves. CarboSOIL predicted increases of SOC stocks in future climate scenarios in the upper soil section (0-25 cm) for areas under rotating wheat, cotton and other annual crops. In this case, SOC stocks increases are considerably larger in the areas above 400 masl. In the 25-50 cm soil section, SOC stocks are expected to decrease in the 2040 scenario and then increase in the following 2070 and 2100 scenarios, particularly in olive-cropped areas. Oppositely, SOC stocks from olive-cropped soils will decrease in the 50-75 soil section in the 2070 scenario. Key words: Carbon sequestration, Global change, Land evaluation, MicroLEIS DSS, Topography. References Abd-Elmabod, S.K., Ali, R.R., Anaya-Romero, M., De la Rosa, D. 2010. Evaluating soil contamination risks using MicroLEIS DSS in El-Fayoum province, Egypt. In: 2nd International Conference on Chemical, Biological and Environmental Engineering (ICBEE), 2-4 November, 2010. Cairo. Pp.: 1-5. DOI: 10.1109/ICBEE.2010.5651591. Abd-Elmabod, S.K., Ali, R.R., Anaya-Romero, M., Jordán, A., Muñoz-Rojas, M., Abdelmageed, T.A., Zavala, L.M., De la Rosa, D. 2012. Evaluating soil degradation under different scenarios of agricultural land management in Mediterranean región. Nature and Science 10, 103-116. De la Rosa, D., Mayol, F., Moreno, F., Cabrera, F., Díaz-Pereira, E., Antoine, J. 2002. A multilingual soil profile database (SDBm Plus) as an essential part of land resources information systems. Environmental Modelling & Software 17, 721-730. DOI: 10.1016/S1364-8152(02)00031-2 Muñoz-Rojas, M., De la Rosa, D., Zavala, L.M., Jordán, A., Anaya-Romero, M. 2011. Changes in land cover and vegetation carbon stocks in Andalusia, Southern Spain (1956-2007). Science of the Total Environment 409, 2796-2806. DOI: 10.1016/j.scitotenv.2011.04.009. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., De la Rosa, D., Abd-Elmabod, S.K., Anaya-Romero, M. 2012a. Impact of land use and land cover changes on organic carbon stocks in Mediterranean soils (1956-2007). Land Degradation & Development. In press. DOI: 10.1002/ldr.2194. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., De la Rosa, D., Abd-Elmabod, S.K., Anaya-Romero, M. 2012b. Organic carbon stocks in Mediterranean soil types under different land uses (Southern Spain). Solid Earth 3, 375-386. DOI: 10.5194/se-3-375-2012. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., González-Peñaloza, F.A., De la Rosa, D., Anaya-Romero, M. 2013a. Modelling soil organic carbon stocks in global change scenarios: a CarboSOIL application. Biogeosciences Discussions 10, 10997-11035. DOI: 10.5194/bgd-10-10997-2013. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., De la Rosa, D., González-Peñaloza, F.A., Abd-Elmabod, S.K., Anaya-Romero, M. 2013b. Climate change impacts on carbon stocks of Mediterranean soils: a CarboSOIL model application. Geophysical Research Abstracts 15, EGU2013 1676.

Shigella gets captured to gain entry.

PubMed

McCormick, Beth A

2011-06-16

The type III secretion system-dependent epithelial invasion and dissemination of Shigella is stimulated by ATP released through hemichannels. Romero et al. (2011) show that prior to epithelial contact, Shigella is captured by nanometer-thin micropodial extensions at a distance from the cell surface, in a process involving ATP and connexin-mediated signaling. Copyright © 2011 Elsevier Inc. All rights reserved.

DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts.

PubMed

Paraskevopoulou, Maria D; Vlachos, Ioannis S; Karagkouni, Dimitra; Georgakilas, Georgios; Kanellos, Ilias; Vergoulis, Thanasis; Zagganas, Konstantinos; Tsanakas, Panayiotis; Floros, Evangelos; Dalamagas, Theodore; Hatzigeorgiou, Artemis G

2016-01-04

microRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like function of lncRNAs introduces an extra layer of complexity in the miRNA interactome. DIANA-LncBase v1 provided a database of experimentally supported and in silico predicted miRNA Recognition Elements (MREs) on lncRNAs. The second version of LncBase (www.microrna.gr/LncBase) presents an extensive collection of miRNA:lncRNA interactions. The significantly enhanced database includes more than 70 000 low and high-throughput, (in)direct miRNA:lncRNA experimentally supported interactions, derived from manually curated publications and the analysis of 153 AGO CLIP-Seq libraries. The new experimental module presents a 14-fold increase compared to the previous release. LncBase v2 hosts in silico predicted miRNA targets on lncRNAs, identified with the DIANA-microT algorithm. The relevant module provides millions of predicted miRNA binding sites, accompanied with detailed metadata and MRE conservation metrics. LncBase v2 caters information regarding cell type specific miRNA:lncRNA regulation and enables users to easily identify interactions in 66 different cell types, spanning 36 tissues for human and mouse. Database entries are also supported by accurate lncRNA expression information, derived from the analysis of more than 6 billion RNA-Seq reads. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Control of Anion in Corporation in the Molecular Beam Epitaxy of Ternary Antimonide Superlattices for Very Long Wavelength Infrared Detection (Postprint)

DTIC Science & Technology

2015-10-01

ASSIGNED DISTRIBUTION STATEMENT. //Signature// //Signature// GAIL J. BROWN DIANA M. CARLIN, Chief Nanoelectronic ...Materials Branch Nanoelectronic Materials Branch Functional Materials Division Functional Materials Division //Signature// KAREN

76 FR 52934 - Submission for OMB Review; Comment Request

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2011-08-24

... DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will... Auxiliary members report observations of changes that require additions, corrections or revisions to... writing Diana Hynek, Departmental Paperwork Clearance Officer, (202) 482-0266, Department of Commerce...

The Legal Implication of Cultural Bias in the Intelligence Testing of Disadvantaged School Children

ERIC Educational Resources Information Center

Georgetown Law Journal, 1973

1973-01-01

The court cases and legal codes cited in this article include: Brown v. Board of Education, 1954; Hobson v. Hansen, 1967; Diana v. State Board of Education (Calif.), 1970; and, California Education Code, 1972. (SF)

Maximum heat of mass concrete - phase 2.

DOT National Transportation Integrated Search

2016-11-01

The main findings and recommendations from this study are as follows: : (1) The database of adiabatic temperature rise tables which was developed in this study can be used in the DIANA software for the modeling of mass concrete structures. : (2) Clas...

77 FR 26779 - Endangered Species; Receipt of Applications for Permit

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... Boidae Genera: Panthera Tragopan Species: snow leopard (Uncia uncia) black-footed cat (Felis nigripes... diana) mandrill (Mandrillus sphinx) lar gibbon (Hylobates lar) siamang (Symphalangus syndactylus) snow leopard (Uncia uncia) leopard (Panthera pardus) cheetah (Acinonyx jubatus) South American tapir (Tapirus...

75 FR 12532 - International Energy Agency Meetings

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... DEPARTMENT OF ENERGY International Energy Agency Meetings AGENCY: Department of Energy. ACTION: Notice of meetings. SUMMARY: The Industry Advisory Board (IAB) to the International Energy Agency (IEA...: Diana D. Clark, Assistant General for International and National Security Programs, Department of Energy...

75 FR 55799 - Government-Owned Inventions; Availability for Licensing

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2010-09-14

... against polyomaviruses. Development Status: Pre-clinical. Inventors: Christopher B. Buck and Diana V... can serve as positive controls in chemokine receptor studies designed to identify novel... chemokine studies. Experimental verification of response to CXC family chemokines: The scientists have...

Radar Cross Section (RCS) Simulation for Wind Turbines

DTIC Science & Technology

2013-06-01

SECTION (RCS) SIMULATION FOR WIND TURBINES by Cuong Ton June 2013 Thesis Advisor: David C. Jenn Second Reader: Ric Romero THIS PAGE...TITLE AND SUBTITLE RADAR CROSS SECTION (RCS) SIMULATION FOR WIND TURBINES 5. FUNDING NUMBERS 6. AUTHOR(S) Cuong Ton 7. PERFORMING ORGANIZATION...ABSTRACT (maximum 200 words) Wind - turbine power provides energy-independence and greenhouse-gas reduction benefits, but if wind turbines are built

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... DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will... certificates, and 30 minutes for certificate change notifications and exception to procedures. Needs and Uses... writing Diana Hynek, Departmental Paperwork Clearance Officer, (202) 482-0266, Department of Commerce...

77 FR 63314 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

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... (E. Ann Worthy, Vice President) 2200 North Pearl Street, Dallas, Texas 75201-2272: 1. James Leon... Irrevocable Trust; Diana McBay Bradley, James Leon Bradley, Jr.; and Christopher Richard Bradley, all of...

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... DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will... occasion. Respondent's Obligation: Required to obtain or retain benefits. OMB Desk Officer: OIRA_Submission... writing Diana Hynek, Departmental Paperwork Clearance Officer, (202) 482-0266, Department of Commerce...

Technology, Education, and the Changing Nature of Resistance.

ERIC Educational Resources Information Center

Rickard, Wendy

1999-01-01

Discusses information technology in higher education. Includes comments from Educom Medal Awards winners honored for contributions made to improving undergraduate education through information technology: Paul Velleman, Cornell; Diana Eck, Harvard; Richard Larson, Stony Brook; David Fulker, University Corporation; and Stephen Ressler, Military…

AAHE Bulletin, 1996-97.

ERIC Educational Resources Information Center

Marchese, Theodore J., Ed.

1997-01-01

The 10 issues of this bulletin present reports, reviews and essays on issues concerning the advancement of higher education. Major articles include: "Learning, Teaching Technology"--an interview with Diana Laurillard of Britain's Open University; "Learning, Technology, and the Way We Work" (Russ Edgerton and Barbara Leigh…

77 FR 66956 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

...://www.regulations.gov . Follow the instructions for submitting comments. Mail: Federal Docket Management... Transportation Command, Command Change Management, ATTN: Diana Roach, 508 Scott Drive, Scott Air Force Base, IL... more effective in providing global mobility solutions to support customer requirements in peace and war...

Detection of pathogenic Yersinia enterocolitica in foods and water by immunomagnetic separation, nested polymerase chain reactions, and colorimetric detection of amplified DNA.

PubMed Central

Kapperud, G; Vardund, T; Skjerve, E; Hornes, E; Michaelsen, T E

1993-01-01

A two-step polymerase chain reaction (PCR) procedure with two nested pairs of primers specific for the yadA gene of Yersinia enterocolitica was developed. The PCR assay identified all common pathogenic serogroups (O:3, O:5,27, O:8, O:9, O:13, and O:21) from three continents and differentiated pathogenic Y. enterocolitica from Y. pseudotuberculosis and from a variety of nonpathogenic yersiniae representing 25 serogroups and four species. The performance of the method was evaluated with seeded food and water samples. We compared two procedures for sample preparation prior to PCR: one was based on immunomagnetic separation of the target bacteria from the sample, using magnetic particles coated with immunoglobulin antibodies to Y. enterocolitica serogroup O:3, and the other method consisted of a series of centrifugation steps combined with proteinase treatment. Regardless of the method used, the PCR assay was capable of detecting 10 to 30 CFU/g of meat in 10(6)-fold excess of indigenous bacteria. When the samples were enriched overnight in a nonselective medium, the sensitivity was increased to approximately 2 CFU/g, except for samples with an extremely high background flora (> 10(7) CFU/g). We compared gel electrophoretic detection of PCR products with a colorimetric detection method designated DIANA (detection of immobilized amplified nucleic acids), which enabled easy visualization of amplified fragments in a microtiter plate format with an optical density reader. DIANA and gel electrophoresis showed complete concordance in their discrimination between positive and negative samples. The combination of immunomagnetic separation, nested PCR, and DIANA makes possible the development of a fully automated analytic process which requires a minimum of laboratory manipulations. Images PMID:8215366

3DIANA: 3D Domain Interaction Analysis: A Toolbox for Quaternary Structure Modeling

PubMed Central

Segura, Joan; Sanchez-Garcia, Ruben; Tabas-Madrid, Daniel; Cuenca-Alba, Jesus; Sorzano, Carlos Oscar S.; Carazo, Jose Maria

2016-01-01

Electron microscopy (EM) is experiencing a revolution with the advent of a new generation of Direct Electron Detectors, enabling a broad range of large and flexible structures to be resolved well below 1 nm resolution. Although EM techniques are evolving to the point of directly obtaining structural data at near-atomic resolution, for many molecules the attainable resolution might not be enough to propose high-resolution structural models. However, accessing information on atomic coordinates is a necessary step toward a deeper understanding of the molecular mechanisms that allow proteins to perform specific tasks. For that reason, methods for the integration of EM three-dimensional maps with x-ray and NMR structural data are being developed, a modeling task that is normally referred to as fitting, resulting in the so called hybrid models. In this work, we present a novel application—3DIANA—specially targeted to those cases in which the EM map resolution is medium or low and additional experimental structural information is scarce or even lacking. In this way, 3DIANA statistically evaluates proposed/potential contacts between protein domains, presents a complete catalog of both structurally resolved and predicted interacting regions involving these domains and, finally, suggests structural templates to model the interaction between them. The evaluation of the proposed interactions is computed with DIMERO, a new method that scores physical binding sites based on the topology of protein interaction networks, which has recently shown the capability to increase by 200% the number of domain-domain interactions predicted in interactomes as compared to previous approaches. The new application displays the information at a sequence and structural level and is accessible through a web browser or as a Chimera plugin at http://3diana.cnb.csic.es. PMID:26772592

Implementation of hybrid clustering based on partitioning around medoids algorithm and divisive analysis on human Papillomavirus DNA

NASA Astrophysics Data System (ADS)

Arimbi, Mentari Dian; Bustamam, Alhadi; Lestari, Dian

2017-03-01

Data clustering can be executed through partition or hierarchical method for many types of data including DNA sequences. Both clustering methods can be combined by processing partition algorithm in the first level and hierarchical in the second level, called hybrid clustering. In the partition phase some popular methods such as PAM, K-means, or Fuzzy c-means methods could be applied. In this study we selected partitioning around medoids (PAM) in our partition stage. Furthermore, following the partition algorithm, in hierarchical stage we applied divisive analysis algorithm (DIANA) in order to have more specific clusters and sub clusters structures. The number of main clusters is determined using Davies Bouldin Index (DBI) value. We choose the optimal number of clusters if the results minimize the DBI value. In this work, we conduct the clustering on 1252 HPV DNA sequences data from GenBank. The characteristic extraction is initially performed, followed by normalizing and genetic distance calculation using Euclidean distance. In our implementation, we used the hybrid PAM and DIANA using the R open source programming tool. In our results, we obtained 3 main clusters with average DBI value is 0.979, using PAM in the first stage. After executing DIANA in the second stage, we obtained 4 sub clusters for Cluster-1, 9 sub clusters for Cluster-2 and 2 sub clusters in Cluster-3, with the BDI value 0.972, 0.771, and 0.768 for each main cluster respectively. Since the second stage produce lower DBI value compare to the DBI value in the first stage, we conclude that this hybrid approach can improve the accuracy of our clustering results.

Age and petrogenesis of the Diana Complex, Adirondack Mountains, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grant, N.; Yang, Yingping; Cliff, R.

1992-01-01

U-Pb zircon data show that the Diana Complex was emplaced 1152[plus minus]12 Ma ago along the Carthage-Colton Mylonite Zone (CCMZ), that marks the boundary between the Adirondack Highlands and the Lowlands. The tectonic setting of the Complex is uncertain because granitoid plutons of the same age were emplaced under syntectonic conditions in the Lowlands, while in the Highlands the same plutons have been viewed as anorogenic. Deformation focused on the CCMZ is reflected in whole-rock Rb-Sr isochron age of 1038[plus minus]97 Ma for the Complex. This resetting is typical of granitoid plutons within a 10 km-wide zone across the CCMZ,more » but is absent outside this zone elsewhere in the Lowlands. Although the chemical continuity of the Complex with Adirondack mafic rocks of the same presumed age demonstrates that crystal fractionation from a basic parent was a likely origin for the Complex, it is probable the magmas were modified by crustal assimilation. For example, the initial [sup 87]Sr/[sup 86]Sr[sub 1152] values for the Complex (0.7042[plus minus]3) are higher than the same ratios for Adirondack mafic rocks (0.7033[plus minus]6), and one zircon fraction lies to the right of the discordia defined by the other four analyzed fractions. The nature and age of the assimilant may be constrained by a metasedimentary xenolith with a whole-rock Rb-Sr isochron age of 1318[plus minus]15 Ma. Changes in TiO[sub 2] and P[sub 2]O[sub 5] abundances and La/Yb values indicate that the crystallization of both accessory (e.g., Fe-Ti oxides, apatite and zircon) and silicate phases were important in the fractionation of the Diana Complex syenites.« less

A Seer of Trump's Coming Parses Repeal and Replace.

PubMed

Kirkner, Richard Mark

2017-03-01

Diana Furchtgott-Roth, a senior fellow at the Manhattan Institute, a freemarket think tank, confidently predicted back in October what few people saw coming-Donald Trump's electoral victory. Now she gives her take on the dismantling of the ACA and what might come after.

Flexible Learning Strategies in Higher and Further Education.

ERIC Educational Resources Information Center

Thomas, Diana, Ed.

This book contains 15 papers written by contributors from all areas of Great Britain in further and higher education. The following papers are included: "Learning to Be Flexible" (Diana Thomas); "Managing Change: Towards a New Paradigm?" (Mac Stephenson, Timothy Lehmann); "Open Learning: Educational Opportunity or…

Protecting the Privacy of Individuals in Terrorist Tracking Applications

DTIC Science & Technology

2005-04-01

THE PRIVACY OF INDIVIDUALS IN TERRORIST TRACKING APPLICATIONS 6. AUTHOR(S) Teresa Lunt, Paul Aoki, Dirk Balfanz , Glenn Durfee, Philippe Golle...in Data Mining and Knowledge Discovery. 3) Brent Waters, Dirk Balfanz , Glenn Durfee, and Diana Smetters. Building an encrypted and searchable audit

Penn Working Papers in Educational Linguistics, Volume 5, Number 2.

ERIC Educational Resources Information Center

Riley, Kathryn, Ed.

The working papers contained in this volume include the following: "Research on Language Learning; How Can It Respond to Classroom Concerns?" (Teresa Pica); "Building Rapport Through Indirect Complaints: Implications for Language Learning" (Diana Boxer); "(Bi)literacy and Empowerment: Education for Indigenous Groups in…

RP-US Balikatan Exercises: A Peace-Building Tool for Mindanao

DTIC Science & Technology

2005-12-01

Silencing of the Guns, eds. Chandra K. Roy, Victoria Tauli-Corpuz , and Amanda Romero-Medina, (Baguio City, Philippines, Tebtebba Foundation, 2004...and the Rajah Sulaiman Movement, a group of idealistic Filipino Muslim converts from the Manila area.131 Douglas Lovelace , Director of the US Army... Lovelace , Director of Strategic Studies Institute, in Zachary Abuza, “Balik- Terrorism: The Return of the Abu Sayyaf,” Strategic Studies Institute, US Army

Islamism and Radicalism in the Maldives

DTIC Science & Technology

2011-12-01

traffic in ancient times. Numerous commercial vessels sailed these waters on their journeys to the Far East, as well as fishermen from the coastal areas...races of ancient civilizations such as Mesopotamia and Indus, revered the sun. They claimed to be descendants of the sun and considered it their...Romero-Frias, The Maldive Islanders: A Study of the Popular Culture of an Ancient Ocean Kingdom (Barcelona: Nova Ethnographica Indica, 1999). This is

[Gender and work: the experience of providers of health services to indigenous women from Guerrero y Oaxaca].

PubMed

Amaya-Castellanos, Claudia Isabel; Pelcastre-Villafuerte, Blanca; Márquez-Serrano, Margarita; Juárez-Ramírez, Clara

2012-03-01

The scope of this paper was to identify the role of gender for women as workers, through the perception and discourse of health service providers at the 'Health Centers for Indigenous Women' ("Casas de Salud de las Mujeres Indígenas") in Ometepec, Guerrero and Matías Romero, Oaxaca, Mexico. It is a qualitative study, based on a secondary analysis of the interviews conducted as part of the "Rescatando la experiencia de la Casa de la Mujer Indígena: sistematización y evaluación del proceso" project. A strong sense of the value of work and a strong commitment towards the community were identified. Guilt appears as the result of tension between work outside the home and the responsibilities as mothers and wives. The possibility of helping other women is a source of gratification that dissipates these conflicts; prestige and recognition are added to the benefits of their role. The labor experience of female workers in the "Casas de Salud de las Mujeres Indígenas" of Matías Romero, Oaxaca and Ometepec, Guerrero, described in this paper, reveals that it has very specific characteristics, which are difficult to replicate in other regions of the country. In future studies it is necessary to consider the different contexts of vulnerability.

Generalized Stability Analysis of Capillary Flow in Slender V-Grooves

NASA Astrophysics Data System (ADS)

White, Nicholas; Troian, Sandra

2017-11-01

Spontaneous capillary flow, an especially rapid process in slender open microchannels resembling V-grooves, is of significant importance to many applications requiring passive robust flow control. Many types of biomedical devices for point-of-care use in developing countries are being designed around this principle. Important fundamental work by Romero and Yost (1996) and Weislogel (1996) elucidated the behavior of Newtonian films in slender V-grooves driven to flow by the streamwise change in capillary pressure due to the change in radius of curvature of the circular arc describing the interface of wetting or non-wetting fluids. Self-similar solutions describing Washburn type dynamics were found but other solutions are possible. Here we extend the Romero and Yost model to include a variety of inlet and outlet boundary conditions and examine the transient growth and generalized stability of perturbations to steady state and self-similar flows. Although most cases examined for wetting fluids exhibit robust stability against small perturbations, some exceptions reveal unstable flow. In total, these results support decades of experimental work which has found this method of flow control to be especially reliable, robust and self-healing. The authors gratefully acknowledge financial support from the 2016 NASA/Jet Propulsion Laboratory President's and Director's Fund as well as a 2017 NASA Space Technology Research Fellowship.

Electrified Flow in Slender V-Groove Microchannels: Generalized Stability of Steady State Configurations

NASA Astrophysics Data System (ADS)

Markeviciute, Vilda; White, Nicholas; Troian, Sandra

2017-11-01

Although spontaneous capillary flow can be an especially rapid process in slender open microchannels resembling V-grooves, enhanced flow control is possible through implementation of electric field distributions which generate opposing electrohydrodynamic pressures along the air/liquid interface to modulate the capillary pressures. Important fundamental work by Romero and Yost (1996) and Weislogel(1996) has elucidated the behavior of Newtonian films in slender V-grooves driven to flow solely by the streamwise change in capillary pressure due to the change in radius of curvature of the circular arc describing the interface of wetting or non-wetting fluids. Here we augment the Romero and Yost model with inclusion of Maxwell stresses for perfectly conducting wetting films and examine which electric field distributions allow formation of steady state film shapes for various inlet and outlet boundary conditions. We investigate the stability of these steady solutions to small perturbations in film thickness using a generalized stability analysis. These results reveal how the ratio of Maxwell to capillary stresses influences the degree of linearized transient growth or decay for thin films confined to flow within an open V-groove. Funding from the 2017 Caltech Summer Undergraduate Research Fellowship Program (Markeviciute) as well as a 2017 NASA Space Technology Research Fellowship (White) is gratefully acknowledged.

76 FR 47539 - Submission for OMB Review; Comment Request

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... of information under the provisions of the Paperwork Reduction Act (44 U.S.C. chapter 35). Agency: U... critical decision-making on a variety of issues including market trends, analysis, and segmentation. Each... proposal can be obtained by calling or writing Diana Hynek, [[Page 47540

Working Papers in Educational Linguistics, Volume 11, Number 1.

ERIC Educational Resources Information Center

Nabors, Leslie K., Ed.; And Others

1995-01-01

Five papers on applied linguistics in educational contexts are presented. "What Can Second Language Learners Learn from Each Other? Only Their Researcher Knows for Sure" (Teresa Pica, Felicia Lincoln-Porter, Diana Paninos, Julian Linnell) presents further research on interaction and negotiation among language learners.…

75 FR 81211 - Submission for OMB Review; Comment Request

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2010-12-27

... gain first-hand experience with field research activities through the Teacher at Sea Program. Through... information collection proposal can be obtained by calling or writing Diana Hynek, Departmental Paperwork...., Washington, DC 20230 (or via the Internet at [email protected] ). Written comments and recommendations for the...

75 FR 12174 - Proposed Information Collection; Comment Request; Request for Special Priorities Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Proposed Information Collection; Comment.... ACTION: Notice. SUMMARY: The Department of Commerce, as part of its continuing effort to reduce paperwork...: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance Officer, Department of...

Women at the Top.

ERIC Educational Resources Information Center

Vail, Kathleen

1999-01-01

Profiles Diana Lam, Gerry House, and Esperanza Zendejas, who accomplished what few women do: they became school superintendents. Qualified female candidates for superintendents are out there. School boards need to pay attention to the way they hire personnel and focus on leadership skills. In addition, boards can support professional memberships…

77 FR 66957 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

... . Follow the instructions for submitting comments. Mail: Federal Docket Management System Office, 4800 Mark... Management, ATTN: Diana Roach, 508 Scott Drive, Scott Air Force Base, IL 62225 or call at (618) 220- 1724... more effective in providing global mobility solutions to support customer requirements in peace and war...

Working with Staff Using Baumrind's Parenting Styles Framework

ERIC Educational Resources Information Center

Veldhuis, Hollace Anne

2012-01-01

The author's presentation at the staff meeting centered on Diana Baumrind's parenting styles framework (Baumrind, 1967). Baumrind believed that there were four requirements for effective guidance: nurturing, communication, maturity demands, and control. She rated parents on these four dimensions and identified the pattern of parenting that…

76 FR 10341 - Air University Board of Visitors Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... Technology conference room located in building 646, room 302. Please contact Mrs. Diana Bunch, 334-953-4547... advice and recommendations on matters pertaining to the educational, doctrinal, and research policies and... initiatives of Air University educational programs with a particular interest of the Air Force Institute of...

The Role of Parents in the Development of Peer Group Competence. ERIC Digest.

ERIC Educational Resources Information Center

Moore, Shirley G.

Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

75 FR 44758 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... the above information collection proposal can be obtained by calling or writing Diana Hynek... submit to the Office of Management and Budget (OMB) for clearance the following proposal for collection of information under the provisions of the Paperwork Reduction Act (44 U.S.C. Chapter 35). Agency...

DESIGNING SULFATE-REDUCING BACTERIA FIELD-BIOREACTORS USING THE BEST MODEL

EPA Science Inventory

DESIGNING SULFATE-REDUCING BACTERIA FIELD-BIOREACTORS USING THE BEST MODEL

Marek H. Zaluski1,3, Brian T. Park1, Diana R. Bless2

1 MSE Technology Applications; 200 Technology Way, Butte, Montana 59701, USA
2 U.S. EPA, Office of Research and Development, Cincinna...

78 FR 20632 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

... Management Project, Rio Grande National Forest, Review Period Ends: 05/17/2013, Contact: Diana McGinn 719-852... Creek Management Area Proposed Resource Management Plan, Review Period Ends: 05/06/2013, Contact: Sky.... EIS No. 20130082, Draft Supplement, FERC, ME, Downeast Liquefied Natural Gas (LNG) Project, Comment...

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Musician Diana Krall sings ""Fly Me to the Moon" during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Paul E. Alers)

Should Teachers Help Students Develop Partisan Identities?

ERIC Educational Resources Information Center

Hess, Diana E.; McAvoy, Paula

2014-01-01

Five years ago, Diana Hess was teaching a graduate seminar called "Democratic Education." The purpose of the seminar was to critically analyze two seemingly simple, but actually very complex, questions: What is democracy? What is democratic education? Both are contested concepts, and the seminar was designed to help students understand…

REVIEW OF REFLECTIONS IN BULLOUGH'S POND: ECONOMY AND ECOSYSTEM IN NEW ENGLAND

EPA Science Inventory

Reflections in Bullough's Pond is a fascinating and eye opening chronicle of New England from pre-European settlement to present times. Author Diana Muir uses the history of the pond in her backyard to individualize the story she tells. It's a powerful device that makes her arg...

On Common Ground: Prominent Women Talk about Work & Family.

ERIC Educational Resources Information Center

Zuckerman, Diana, Ed.

This publication presents interviews with 11 prominent women, representing different backgrounds, philosophies, and life experiences, in which they speak about their own experiences with work and family issues. The introduction, "On Common Ground: Prominent Women Talk about Work & Family" (Diana Zuckerman), provides an overview. The 11 interviews…

Language and Music as Communication: A Discussion.

ERIC Educational Resources Information Center

Brown, Roger; And Others

1979-01-01

Roger Brown, Diana Deutsch, Warren Benson, and Ruth Day comment on the similarities and differences between verbal language and music as forms of communication. This discussion occurred at the first session of the National Symposium on the Applications of Psychology to the Teaching and Learning of Music, Ann Arbor. (SJL)

Enterprise Risk Management: The Way Ahead for DRDC within the DND Enterprise

DTIC Science & Technology

2010-03-01

Taleb Distributions, the Hurst Exponent (to deal with long time events), Life Extinction Events, Zero-Infinity Dilemmas (which characterize the...Time dependent Hurst exponent in financial time series”, Physica A 344 (2004) 267-271 35. Yoav Ben-Shlomo and Diana Koh, “A Life Course Approach to

Screening Mammography: Science, Policy and Politics–The Good, the Bad and the Ugly

Cancer.gov

Diana Petitti, MD, MPH, FACPM, an epidemiologic expert on women's health and evidence based medicine, with posts as vice chair and spokesperson for the U.S. Preventive Service Task Force, presented "Screening Mammography: Science, Policy and Politics–The Good, the Bad and the Ugly." 

Effects of Repetition on Associative Recognition in Young and Older Adults: Item and Associative Strengthening

DTIC Science & Technology

2010-01-01

familiarity (e.g., Diana, Reder, Arndt, & Park, 2006; Jacoby, 1991; Mandler, 1980; Reder, Nhouvanisvong, Schunn, Ayers, Angstadt, & Hiraki , 2000...Schunn, C. D., Ayers, M. S., Angstadt, P., & Hiraki , K. (2000). A mechanistic account of the mirror effect for word frequency: A computational model of

75 FR 12173 - Proposed Information Collection; Comment Request; Defense Priorities and Allocations System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... Allocations System regulation (15 CFR part 700) must retain the records for at least 3 years. II. Method of... Request; Defense Priorities and Allocations System AGENCY: Bureau of Industry and Security, Commerce...: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance Officer, Department of...

Women and Technical Professions. Leonardo da Vinci Series: Good Practices.

ERIC Educational Resources Information Center

Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

This document profiles programs for women in technical professions that are offered through the European Commission's Leonardo da Vinci program. The following programs are profiled: (1) Artemis and Diana (vocational guidance programs to help direct girls toward technology-related careers); (2) CEEWIT (an Internet-based information and…

Mini-Portfolio on Math and Science.

ERIC Educational Resources Information Center

Teaching PreK-8, 1996

1996-01-01

Presents six articles dealing with math and science education: "Sneaker Geometry" (Jack George), "Fairs with a Flair" (Diane McCarty), "Generating Excitement with Math Projects" (Jeffrey Kostecky and Louis Roe), "Playing with Numbers" (Diana Smith), "When Student Teachers Want to Do Hands-On Science" (Betsy Feldkamp-Price), and "Science ala Carte"…

New Magnetic Materials and Phenomena for Radar and Microwave Signal Processing Devices - Bulk and Thin Film Ferrites and Metallic Films

DTIC Science & Technology

2009-02-15

Magnon scattered light generally experiences a 90° rotation in polarization from the incident beam. The wave- vector selective BLS measurements...filters, phase locked microwave pulse sources, microwave and millimeter wave devices such as isolators, circulators, phase shifters, secure signal...Wave vector selective Brillouin light scattering measurements and analysis, " C. L. Ordofiez-Romero, B. A. Kalinikos, P. Krivosik, Wei Tong, P

8. MACHINERY SHED STORAGE ROOM ADDITION DETAIL SHOWING MATRIX OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. MACHINERY SHED STORAGE ROOM ADDITION DETAIL SHOWING MATRIX OF NAILS USED TO ADHERE PORTLAND CEMENT PLASTER, SOUTH ADOBE WALL ADJACENT TO WINDOW Note: Photographs Nos. AZ-159-A-9 through AZ-159-A-10 are photocopies of photographs. The original prints and negatives are located in the SCS Tucson Plant Materials Center, Tucson, Arizona. Photographer Ted F. Spaller. - Tucson Plant Material Center, Machinery Shed, 3241 North Romero Road, Tucson, Pima County, AZ

Cast Aluminum Structures Technology (CAST) Phase VI. Technology Transfer.

DTIC Science & Technology

1980-04-01

and other aspects of the program was provided as follows: o Phase I--Preliminary Design Richard C. Jones o Phase il--Manufacturing Methods Richard G...Christner o Phase Ill--Detailed Design Richard C. Jones o Phase IV--Fabrication of Demonstration Richard G. Christner Articles and Production... Richard C. Jones, assisted by Carlos J. Romero, Christian K. Gunther, Cecil E. Parsons, and Donald D. Goehler; and by Walter Hyler of Battelle Columbus

Education, Diversity, and Inclusion in Burmese Refugee Camps in Thailand

ERIC Educational Resources Information Center

Oh, Su-Ann; van der Stouwe, Marc

2008-01-01

This article explores the "two faces" model of education through which Kenneth Bush and Diana Saltarelli (2000) describe the positive and negative roles that education can play in situations of ethnic conflict. The authors apply it more narrowly to analyze the effect of inclusion and diversity in education in a conflict situation. In…

Rethinking "Harmonious Parenting" Using a Three-Factor Discipline Model

ERIC Educational Resources Information Center

Greenspan, Stephen

2006-01-01

Diana Baumrind's typology of parenting is based on a two-factor model of "control" and "warmth". Her recommended discipline style, labeled "authoritative parenting", was constructed by taking high scores on these two factors. A problem with authoritative parenting is that it does not allow for flexible and differentiated responses to discipline…

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Jazz pianist and singer Diana Krall gives an introduction prior to her performance at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Ms. Krall's piano was staged right next to the Apollo 11 Command Capsule. Photo Credit: (NASA/Bill Ingalls)

Teaching for Tomorrow: Integrating LRE and the Social Studies. Bar/School Partnership Programs.

ERIC Educational Resources Information Center

Wolowiec, Jack, Ed.

This collection of four short articles presents teaching strategies to enrich the social studies curriculum and promote students' sense of citizenship. Diana Hess outlines how cooperative learning stimulates the skills necessary for effective participation in a democratic society. By taking an active role in their own education and respecting the…

Rachel's Challenge: A Moral Compass for Character Education

ERIC Educational Resources Information Center

Hollingshead, Barbara; Crump, Christi; Eddy, Rochelle; Rowe, Dina

2009-01-01

Though American life in 1923 was significantly different than the present day, authors John Dewey and Diana Brannon share similar concerns about character. Historically, educators as far back as the 1800s have felt an obligation to the community to transcend the primary purpose for schooling by including character education in their curricula.…

Diana's Eulogy: Breaking New Ground in Epideictic Rhetoric?

ERIC Educational Resources Information Center

Scott, David K.

A speech in response to an individual's death is by nature a recurring form of rhetoric. Based on audience expectations and needs, certain generic aspects have emerged to characterize eulogies. The funeral oration has generally been recognized as a form of epideictic rhetoric. Modern scholars have generally broadly defined epideictic rhetoric to…

Citizenship Education Research in Varied Contexts: Reflections and Future Possibilities. A Review Essay

ERIC Educational Resources Information Center

Tudball, Libby

2015-01-01

Three books are the subject of this review essay: (1) Avril Keating's (2014) publication, "Education for Citizenship in Europe: European Policies, National Adaptations and Young People's Attitudes"; (2) "The Political Classroom: Evidence and Ethics in Democratic Education", Diana Hess and Paula McAvoy (2015); and (3) "We…

Evaluation Strategies and Techniques for Public Library Children's Services: A Sourcebook.

ERIC Educational Resources Information Center

Robbins, Jane; And Others

The 28 papers in this sourcebook relate to the evaluation of children's services in public libraries: (1) "Introduction to Evaluation" (Jane Robbins and Douglas Zweizig); (2) "Research and Measurement in Library Services to Children" (Adele Fasick); (3) "Evaluating Children's Services" (Diana Young); (4) "What Is Good about Children's Library…

Ultralow Loss Optomechanics Using Diagmagnetically Levitated Drops of Liquid Helium

DTIC Science & Technology

2015-03-12

Instruments. The magnet coils ( crossed diagonal lines) enclose a bore that is a vacuum space, and can be accessed from room temperature. A similar magnet and...Review Letters 91, 130401 (2003). 5 Oriol Romero-Isart, Anika C. Pflanzer, Florian Blaser, Rainer Kaltenbaek, Nikolai Kiesel, Markus Aspelmeyer, J...State” Nature 475, 359 (2011). 8 Jasper Chan, T. P. Mayer Alegre, Amir H. Safavi-Naeini, Jeff T. Hill, Alex Krause, Simon Gröblacher, Markus Aspelmeyer

Meningococcal Disease in US Military Personnel Before and after Adoption of Conjugate Vaccine

DTIC Science & Technology

2015-02-01

after Adoption of Conjugate Vaccine Michael P. Broderick , Christopher Phillips, Dennis Faix Author affiliation: Naval Health Research Center, San Diego...1964–1998. Clin Infect Dis. 2002; 35:1376–81. http://dx.doi.org/10.1086/344273 8. Broderick MP, Faix DJ, Hansen CJ, Blair PJ. Trends in meningo...1988. p. 445–7. 10. Patel M, Romero-Steiner S, Broderick MP, Thomas CG, Plikaytis BD, Schmidt DS, et al. Persistence of serogroup C antibody

Development and Translation of Hybrid Optoacoustic/Ultrasonic Tomography for Early Breast Cancer Detection

DTIC Science & Technology

2015-09-01

iterative algorithms of OAT to improve image fidelity. Laser ultrasound is generated through conversion of low -energy (about 100 µJ) 9 ns laser pulses ...Scherzinger, and T. Oughton, “Breast im- aging in coronal planes with simultaneous pulse echo and transmis- sion ultrasound ,” Science, vol. 214, no. 4525, pp...unidirectional pulse -echo ultrasound imaging,” Phys. Med. Biol., vol. 58, no. 17, art. no. 6163, 2013. [41] L. A. Romero, D. C. Ghiglia, C. C. Ober, and S. A

Influence of Wildland Fire on the Recovery of Endangered Plant Species Study Project.

DTIC Science & Technology

1995-10-01

Romero 1995): Estimation of fire severity was difficult for the Kipuka Kalawamauna fire for several reasons. First, flame lengths were not measured...Andrews 1986) include flame length and heat per unit area. Flame length is used as an indicator of upward heat release, while heat per unit area is a...the downward heat pulse. Estimated flame lengths ranged from 3.5 m to 4.0 m depending on degree of slope within the Dodonaea viscosa Jacq. dominated

Thermodynamic and Spectroscopic Properties of Nd:YAG-CO2 Double-Pulse Laser-Induced Iron Plasmas

DTIC Science & Technology

2009-01-01

S. Palanco, L.M. Cabalín, D. Romero, J.J. Laserna, Infrared laser ablation and atomic emission spectrometry of stainless steel at high temperatures, J...is given from thepreparation of the sample by thefirst pulse (smoothing,first crater , onset ofmelt) to the energy couplingwith the plasma (ion yield...duration is 5 ns as measured with a fast photodiode (Thorlabs) placed behind a dielectric turning mirror. The laser is focused with a 13.5 cm focal length

Evaluation of Novel Polyunsaturated Fatty Acid Derived Lipid Mediators of Inflammation to Ameliorate the Deleterious Effects of Blast Overpressure on Eye and Brain Visual Processing Centers in Rats

DTIC Science & Technology

2014-10-01

ferry these drugs across the blood brain barrier after intravenous injection post- blast, such as by packaging them in liposomes or dendrimer based...Kannan RM. (2012). Dendrimer -based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials...Neuroinflammation. 10: 96-102. Kannan S, Dai H, Navath RS, Balakrishnan B, Jyoti A, Romero R, and Kannan RM. (2012). Dendrimer -based targeted

Spring Research Festival and NICBR Collaboration Winners Announced | Poster

Cancer.gov

By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria

The Rules of the Game: Women and the Leaderist Turn in Higher Education

ERIC Educational Resources Information Center

Morley, Louise

2013-01-01

This paper engages with Diana Leonard's writing on how gender is constituted in the academy. It offers an international review of feminist knowledge on how gender and power interact with leadership in higher education. It interrogates the "leaderist turn" or how leadership has developed into a popular descriptor and a dominant social and…

How Schools Can Support Children Who Experience Loss and Death

ERIC Educational Resources Information Center

Holland, John

2008-01-01

Scenes of public grieving such as followed the death of Princess Diana bear little resemblance to the "taboo" status of death and bereavement at an individual level. For schools and the support services with whom they work, responding to pupils' experiences of loss and death, especially of parents, is challenging. This paper draws on…

Using Group-Based Learning in Higher Education. Teaching and Learning in Higher Education Series.

ERIC Educational Resources Information Center

Thorley, Lin, Ed.; Gregory, Roy, Ed.

The 26 papers in this collection from a British conference first provide an overview of group-based learning in higher education, offer a range of examples, and identify issues and trends. Chapters include: (1) "Introduction" (Roy Gregory and Lin Thorley); (2) "An Overview from Higher Education" (Diana M. R. Tribe); (3)…

Handbook of Parenting. Volume 5: Practical Issues in Parenting. Second Edition.

ERIC Educational Resources Information Center

Bornstein, Marc H., Ed.

Concerned with practical aspects of meeting children's needs, this volume, the fifth of five on parenting, describes the nuts and bolts of parenting as well as the promotion of positive parenting practices. The volume consists of the following 19 chapters: (1) "The Ethics of Parenting" (Diana Baumrind and Ross A. Thompson; (2) "Parenting and…

Parents as Leaders: The Role of Control and Discipline.

ERIC Educational Resources Information Center

Yahraes, Herbert

This paper reviews Diana Baumrind's studies of the effect of various types of parental control on children's behavior and concludes that a child is more likely to develop a sense of competence, responsibility, and independence if he or she is given firm and reasonable guidelines. A brief survey of Baumrind's first two studies of preschool children…

Making Matter Making Us: Thinking with Grosz to Find Freedom in New Feminist Materialisms

ERIC Educational Resources Information Center

Jackson, Alecia Youngblood

2013-01-01

In this paper, I offer a very close reading of Grosz [2010. "Feminism, Materialism, and Freedom." In "New Materialisms: Ontology, Agency, and Politics," edited by Diana Coole and Samantha Frost, 139-157. Durham, NC: Duke University Press] thinking with Bergson in order to re-conceptualise freedom, matter, and the subject in new…

78 FR 26867 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... residents, as defined in section 877(e)(2), are treated as if they were citizens of the United States who... GERRING BANG HEESEUNG BARRAZA SANTIAGO E BARTEL-MOUFANG DIANA BATTIG RAINER KARL BAUMANN MARTIN PETER... SUSANNE BARBARA HATHAWAY JANET K HAUPTLI DIANE MARIE HAY KATHERINE MARIE HEBRON VERA HEIM JULIA HEIM MARC...

75 FR 69160 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

... Anderson John Derek Anderson Rose Mary Andreen Clas Svante Joel Ang Diana Shu-Zhen Angelini Kevin Yang... Anthony Bergandi Marco Lee Berre Jean N. Berryman Curtis Frederick Beveridge Richard Henry Earle Beveridge... Cheung Mark Quintin Chih-Hsiang Lisa Lee Chiu Sammy Kai-Kong Christianson Marlys Chun Jessica Chung...

Abraham Lincoln and the Pillars of Liberty

ERIC Educational Resources Information Center

Schaub, Diana J.

2002-01-01

In this essay, Diana Schaub, associate professor and chair of the Department of Political Science at Loyola College in Maryland, asserts that the 9/11 attack on America showed students the fallacy not of relativism, but of toleration. They are now aware that there are limits to toleration. By giving such a vivid display of the horrors of…

Where Are All the Black Teachers? Discrimination in the Teacher Labor Market

ERIC Educational Resources Information Center

D'amico, Diana; Pawlewicz, Robert J.; Earley, Penelope M.; McGeehan, Adam P.

2017-01-01

In this article, Diana D'Amico, Robert J. Pawlewicz, Penelope M. Earley, and Adam P. McGeehan examine the racial composition of one public school district's teacher labor market through teacher application data and subsequent hiring decisions. Researchers and policy makers have long noted the lack of racial diversity among the nation's public…

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Former U.S. Sen. John Glenn, left, and musician Diana Krall bow there heads in prayer during a memorial service celebrating the life of Neil Armstrong, Thursday, Sept. 13, 2012, at the Washington National Cathedral. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Missouri Assessment Program (MAP), Spring 2000: Intermediate Communication Arts, Released Items, Grade 7.

ERIC Educational Resources Information Center

Missouri State Dept. of Elementary and Secondary Education, Jefferson City.

This document deals with testing in intermediate communication arts for seventh graders in Missouri public schools. The document contains the following items from the Session 1 Test Booklet: "Swimming in Snow" (Diana C. Conway) (Items 1, 2, and 5); "Discovery" (Marion Dane Bauer) (Item 13); writing prompt; and a writer's…

The Role of Telomeric Repeat Binding Factor 1 (TRF1) in Telomere Maintenance and as a Potential Prognostic Indicator in Human Breast Cancer

DTIC Science & Technology

2006-04-01

for Specific Aim #3 have yet been initiated, and are proceeding on schedule. The PhD candidate has completed her educational goals. 13 Appendix A ... LEVELS OF TELOMERE PROTEIN MRNAS ARE PREDICTIVE OF TELOMERE CONTENT IN HUMAN BREAST TUMORS Kimberly S. Butler, William C. Hines, Diana Roberts

Connecting the Private and the Public: Pregnancy, Exclusion, and the Expansion of Schooling in Africa

ERIC Educational Resources Information Center

Unterhalter, Elaine

2013-01-01

In a number of countries in Africa, young women who become pregnant are excluded from school. This article presents a critique of policy and practice in this area drawing partly on Diana Leonard's scholarship concerning the relational dynamic of gender, generation, social division, and household forms. Much of the policy prescription of large…

Republic of Noise: The Loss of Solitude in Schools and Culture

ERIC Educational Resources Information Center

Senechal, Diana

2011-01-01

In "Republic of Noise," Diana Senechal confronts a culture that has come to depend on instant updates and communication at the expense of solitude. Where once it was common wisdom that the chatter of the present, about the present, could not always grasp the present, today we treat "real time" as though it were the only real time. Schools…

El Papel de los Padres en el Desarrollo de la Competencia Social (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

ERIC Educational Resources Information Center

Moore, Shirley G.

Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

Introduction to "Multicultural Voices: Peer Tutoring and Critical Reflection in the Writing Center"

ERIC Educational Resources Information Center

Grimm, Nancy Maloney

2010-01-01

In 1991 when Diana George, Ed Lotto, and the author were publishing their first issue as "WCJ" editors, this multivoiced essay struck her as a prime example of their editorial belief that writing centers could be "agents of change in the academy." As Gail Okawa and Tom Fox observe, "Most universities are inhospitable to more democratic definitions…

76 FR 9578 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Conducting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-18

... aforementioned meeting: Time and Date: 12:30 p.m.-3 p.m., April 13, 2011 (Closed). Place: Teleconference. Status: The meeting will be closed to the public in accordance with provisions set forth in Section 552b(c) (4..., initial review.'' Contact Person for More Information: Diana Bartlett, M.P.H., Scientific Review Officer...

Vocal production mechanisms in a non-human primate: morphological data and a model.

PubMed

Riede, Tobias; Bronson, Ellen; Hatzikirou, Haralambos; Zuberbühler, Klaus

2005-01-01

Human beings are thought to be unique amongst the primates in their capacity to produce rapid changes in the shape of their vocal tracts during speech production. Acoustically, vocal tracts act as resonance chambers, whose geometry determines the position and bandwidth of the formants. Formants provide the acoustic basis for vowels, which enable speakers to refer to external events and to produce other kinds of meaningful communication. Formant-based referential communication is also present in non-human primates, most prominently in Diana monkey alarm calls. Previous work has suggested that the acoustic structure of these calls is the product of a non-uniform vocal tract capable of some degree of articulation. In this study we test this hypothesis by providing morphological measurements of the vocal tract of three adult Diana monkeys, using both radiography and dissection. We use these data to generate a vocal tract computational model capable of simulating the formant structures produced by wild individuals. The model performed best when it combined a non-uniform vocal tract consisting of three different tubes with a number of articulatory manoeuvres. We discuss the implications of these findings for evolutionary theories of human and non-human vocal production.

First paleoparasitological record of digenean eggs from a native deer from Patagonia Argentina (Cueva Parque Diana archaeological site).

PubMed

María Ornela, Beltrame; Eleonor, Tietze; Alberto Enrique, Pérez; Norma Haydeé, Sardella

2017-02-15

Eggs representative of a digenean species were found in coprolites belonged to an endemic deer from Patagonia. Samples were collected from the archaeological site named "Cueva Parque Diana". This site is a cave located at the Lanín National Park, Neuquén Province, Argentina. The coprolites were dated from 2370±70 to 580±60 years B.P. The eggs were ellipsoidal, operculated, yellowish and thin-shelled. Measurements (n=65) ranged from 120.0 to 142.5 (133.2±6.53) μm long and 62.5 to 87.5 (72.6±6.15) μm wide. Eggs were well-preserved and were identified as belonged to Class Trematoda, Subclass Digenea, similar to those of Fasciola hepatica or with another species not identified at present from Patagonia. This is the first report of digenean eggs from ancient deer worldwide. The present study confirms the presence of representatives of digenean species in endemic deer from Patagonia in ancient times and the presence of a trematode disease prior to the arrival of European cattle. Copyright © 2017 Elsevier B.V. All rights reserved.

Population Based Assessment of MHC Class I Antigens Down Regulation as Markers of Increased Risk for Development and Progression of Breast Cancer from Benign Breast Lesions

DTIC Science & Technology

2007-01-01

cancer. Int J Cancer. 1992;51:379-385. 10. Cabrera T, Collado A, Fernandez MA, et al. 1998. High frequency of altered HLA class I phenotypes in invasive...head and neck squamous cell carcinomas. Human Immunology. 1999;60:697-706. 12. Cabrera T, Salinero J, Fernandez MA, Garrido F. High frequency of...Solano, R., Romero, J., Alonso , C., Pena J. MHC class I antigen expression is inversely related with tumor malignancy and ras oncogene products

The Role of Siah1-Induced Degradation of beta-Catenin in Androgen Receptor Signaling

DTIC Science & Technology

2007-11-01

biological responses to DNA damage: Insights from yeast and p53. Nat. Cell Biol. 3, E277–E286. Winston, J.T., Strack, P., Beer -Romero, P., Chu, C.Y...apoptosis, depending on the cell line tested [3]. The findings suggest that p53-mediated induction of Siah1 expression could play an important role in the...hypothesis that Siah1 is an important mediator of p53’s effects in prostate cancers. If the hypothesis proves to be correct, then the results derived

JiaZhang Dui ErTong FaZhan TongBan GuanXi De ZuoYong (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

ERIC Educational Resources Information Center

Moore, Shirley G.

Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

Systems Engineering Analysis for Office Space Management

DTIC Science & Technology

2017-09-01

Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork...aid in the MCDM process and support the organization making a more informed decision for office resource management . Figure 8. Functional...ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT by James E. Abellana September 2017 Thesis Advisor: Diana Angelis Second Reader: Walter E. Owen

A Sacrificial Lam: A Divided School Board, a Beleaguered Superintendent, and an Urgent Need to Improve Student Achievement

ERIC Educational Resources Information Center

Fossey, Richard

2011-01-01

This case describes the confrontational relationship between four trustees on the San Antonio School Board and the San Antonio School District's superintendent Diana Lam, a nationally recognized school reformer, who came to San Antonio in 1994. The case includes a dramatic board meeting where a closely divided board meets to buy out Lam's…

Good/Bad Girls Read Together: Pre-Adolescent Girls' Co-Authorship of Feminine Subject Positions during a Shared Reading Event.

ERIC Educational Resources Information Center

Enciso, Patricia E.

1998-01-01

Discusses reading with pre-teens Francine Pascal's "Sweet Valley Twins: Best Friends," one of a series of pre-romance novels featuring identical twin sisters. Interviews six girls using the Symbolic Representation Interview (SRI) about the good girl/bad girl dichotomy in novels and other media. Provides comments by Tom Romano and Diana Mitchell.…

Marr: Magpie or Marsh Harrier? The Quest for the Common Characteristics of the Genus "Historian" with 16- to 19-Year-Olds

ERIC Educational Resources Information Center

Laffin, Diana

2012-01-01

Diana Laffin writes about historical language and explores how understanding different historians' use of language can help sixth form students refine and deepen both their understanding of the discipline of history and their abilities to practise the discipline in their own writing. What does close study of the textual habits and practices of…

Analysis of Parental Involvement and Self-Esteem on Secondary School Students in Kieni West Sub-County, Nyeri County, Kenya

ERIC Educational Resources Information Center

Wairimu, Mburu Josephine; Macharia, Susan M.; Muiru, Ann

2016-01-01

This study investigated the relationship between parental involvement and the self-esteem among adolescents in secondary school students in Kieni West District in Nyeri County. It was guided by Self Determination Theory (SDT) by James William and Baumrind Theory of Parenting Styles by Diana Blumberg Baumrind. Some of the gaps identified in the…

You Are Embarked: How a Philosophy Curriculum Took Shape and Took Off

ERIC Educational Resources Information Center

Senechal, Diana

2015-01-01

Diana Senechal teaches philosophy at Columbia Secondary School for Math, Science, and Engineering in New York City; in addition, she serves on the faculty of the Sue Rose Summer Institute for Teachers at the Dallas Institute of Humanities and Culture. In this article she states that if someone had told her five years ago that she would be a high…

Perceived Advantages and Disadvantages of Being a Female Graduate Student in the US and the UK

ERIC Educational Resources Information Center

Mehta, Clare Marie; Keener, Emily; Shrier, Lydia

2013-01-01

We build on Diana Leonard's work on gender and graduate education by qualitatively investigating the perceived advantages and disadvantages of being a female graduate student in the USA and the UK. We interviewed six female students (ages 22-30) pursuing master's degrees in psychology or social sciences in the USA and the UK. Students from both…

Regulated Capacitor Charging Circuit Using a High Reactance Transformer

DTIC Science & Technology

1999-06-01

REGULATED CAPACITOR CHARGING CIRCUIT USING A HIGH REACTANCE TRANSFORMER1 Diana L. Loree and James P. O’Loughlin Air Force Research Laboratory...Directed Energy Directorate Kirtland Air Force Base, NM 87117-5776 Abstract A high reactance transformer circuit is used to provide for the compact...simple, economic and reliable charging of a capacitor energy store to a predetermined and regulated voltage. The circuit can be operated from a

78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... submissions by the parties may be submitted via the Board's e-filing format or in the traditional paper format. Any person using e-filing should attach a document and otherwise comply with the instructions at the E... proceeding under 49 U.S.C. 721 and 5 U.S.C. 554(e). Petitioners request that the Board declare that specific...

Analysis of Contractor Logistics Support for the P-8 Poseidon Aircraft

DTIC Science & Technology

2008-06-01

15. NUMBER OF PAGES 103 14. SUBJECT TERMS Original Equipment Manufacturer, Contractor Logistics Support, P-8A Aircraft , 16. PRICE CODE 17...Communications Rack Mission Equipment Rack Galley G4 INMARSAT Antenna MAD Folding Stairs Crew Rest Observer Stations (2) CFM-56-7B 180 kVA IDG Engines (2...Poseidon Aircraft By: Shane Tallant, Scott Hedrick, and Michael Martin Advisors: Diana Petross Keebom Kang

X-ray Radiative Transfer in Protoplanetary Disks with ProDiMo

NASA Astrophysics Data System (ADS)

Rab, Christian; Woitke, Peter; Güdel, Manuel; Min, Michiel; Diana Team

2013-07-01

X-ray emission is a common property of YSOs. T Tauri stars show X-ray luminosities up to 10^32 erg/s but also Herbig Ae/Be stars can have moderate X-ray emission in the range of 10^28 to 10^31 erg/s. We want to investigate the impact of X-ray radiation on the thermal and chemical structure of protoplanetary discs around these YSOs. Therefore we have added a new X-ray Radiative Transfer module to the radiation thermo-chemical code ProDiMo (Protoplanetary Disc Modeling) extending the existing implementation of X-ray chemistry implemented by Aresu et al. This new module considers gas and dust opacities (including scattering) and a possible X-ray background field. Further we added a new set of FUV - photoreactions to the X-ray chemistry module of ProDiMo as fast electrons created in X-ray ionisation can produce a significant secondary FUV radiation field by exciting atomic or molecular hydrogen. We discuss the importance of these processes on the thermal and chemical structure of the protoplanetary disc, and present them on the basis of a typical T Tauri disc model. This work is performed in the context of the EU FP7-project DIANA (www.diana-project.com).

Profile: Manhiça Health Research Centre (Manhiça HDSS).

PubMed

Sacoor, Charfudin; Nhacolo, Ariel; Nhalungo, Delino; Aponte, John J; Bassat, Quique; Augusto, Orvalho; Mandomando, Inácio; Sacarlal, Jahit; Lauchande, Natu; Sigaúque, Betuel; Alonso, Pedro; Macete, Eusébio; Munguambe, Khátia; Guinovart, Caterina; Aide, Pedro; Menendez, Clara; Acácio, Sozinho; Quelhas, Diana; Sevene, Esperança; Nhampossa, Tacilta

2013-10-01

The Manhiça Health Research Centre, established in 1996 in a rural area of southern Mozambique, currently follows around 92 000 individuals living in approximately 20 000 enumerated and geo-positioned households. Its main strength is the possibility of linking demographic data and clinical data to promote and conduct biomedical research in priority health areas. Socio-demographic data are updated twice a year and clinical data are collected on a daily basis. The data collected in Manhiça HDSS comprises household and individual characteristics, household socio-economic assets, vital data, migration, individual health history and cause of death, among others. Studies conducted in this HDSS contributed to guide the health authorities and decision-making bodies to define or adjust health policies such as the introduction of Mozambique's expanded programme of immunization with different vaccines (Haemophilus influenzae type b, Pneumococcus) or the development of the concept of Intermittent Preventive Treatment for Infants (IPTi) that led to the World Health Organization recommendation of this method as best practice for the control of malaria among infants. Manhiça's data can be accessed through a formal request to Diana Quelhas (diana.quelhas@manhica.net) accompanied by a proposal that will be analysed by the Manhiça HDSS internal scientific and ethics committees.

Bioinformatics analysis for evaluation of the diagnostic potentialities of miR-19b, -125b and -205 as liquid biopsy markers of prostate cancer

NASA Astrophysics Data System (ADS)

Bryzgunova, O. E.; Lekchnov, E. A.; Zaripov, M. M.; Yurchenko, Yu. B.; Yarmoschuk, S. V.; Pashkovskaya, O. A.; Rykova, E. Yu.; Zheravin, A. A.; Laktionov, P. P.

2017-09-01

Presence of tumor-derived cell-free miRNA in biological fluids as well as simplicity and robustness of cell-free miRNA quantification makes them suitable markers for cancer diagnostics. Based on previously published data demonstrating diagnostic potentialities of miR-205 in blood and miR-19b as well as miR-125b in urine of prostate cancer patients, bioinformatics analysis was carried out to follow their involvement in prostate cancer development and select additional miRNA-markers for prostate cancer diagnostics. Studied miRNAs are involved in different signaling pathways and regulate a number of genes involved in cancer development. Five of their targets (CCND1, BRAF, CCNE1, CCNE2, RAF1), according to the STRING database, act as part of the same signaling pathway. RAF1 is regulated by miR-19b and miR-125b, and it was shown to be involved in prostate cancer development by DIANA and STRING databases. Thus, other microRNAs regulating RAF1 expression such as miR-16, -195, -497, and -7 (suggested by DIANA, TargetScan, MiRTarBase and miRDB databases) can potentially be regarded as prostate cancer markers.

A study on family communication pattern and parenting styles with quality of life in adolescent.

PubMed

Sanavi, Fariba Shahhraki; Baghbanian, Abdolvahab; Shovey, Mehdi Faraji; Ansari-Moghaddam, Alireza

2013-11-01

To investigate the relationship between parenting styles and family communication patterns with adolescent's quality of life. The cross-sectional study was carried out on 439 randomly selected adolescents in the city of Zahedan, Iran, from January to July 2011.The subjects were asked to complete the KIDSCREEN-52 health-related quality of life questionnaire, while their parents were asked to complete the Diana Brinder's Test to show their parenting styles. SPSS 15 was used to analyse data. Most parents had 'authoritative' parenting style (n = 380; 86.6%). Pluralistic (n = 170; 38.7%) and consensual (n = 152; 34.6%) patterns were the most frequent styles of communication in families. Data suggested a significant relationship between parenting style and some dimensions of quality of life, including physical well-being, psychological well-being, social support and peers, and autonomy (p < 0.05). There was also a significant relationship between family communication patterns and parent relation and home life (p < 0.001) as well as autonomy (p < 0.006). Families play a critical role in increasing adolescents' health-related quality-of-life. Effort should be made to address problems facing parents while raising their children.

Russia, Religion, and the Rosary: Can Religion be a U.S. Weapon against the Soviet Union?

DTIC Science & Technology

1981-06-05

interests of the Romero Catholic Church, and this church-state fusion persisted until the Twentieth Centurj. 11 SiMilarli, the Russian Orthodo., Church...Reppert, P4 61. 8 David Shiplerý "In Remote Siberia, a Buddhist Center," The New York TiMes, March 10, 1978, p. 1. 9Shipler, p. 1# 48 101 lJaMes...World," The Wall Street Joi...rrnal, ,June 7# 1979, p, 28. 18 aj, p. 28. 1 9 David K<. Shiplert "A RUssian Nationalisi• Is on Rise," The New Yqrk Times

Real-Time Dosimetry and Optimization of Prostate Photodynamic Therapy

DTIC Science & Technology

2006-09-01

photodynamic therapy in patients with prostate cancer,” IPA 9th World Congress of Photodynamic Medicine, (2003). 2. Zhu TC, Diana S, Dimofte A...photodynamic therapy,” IPA 9th World Congress of Photodynamic Medicine, (2003). 3. Zhu TC, Altschuler M, Xiao Y, Finlay J, Dimofte A, Hahn SM, “Light...Optimization of treatment plan using Cimmino algorithm in prostate photodynamic therapy,” IPA 10th World Congress of Photodynamic Medicine, Munich

Marine Mammals Ashore: A Field Guide for Strandings. Second Edition

DTIC Science & Technology

2005-01-01

Cruz, CA (Ch. 9); Diana M. Antochiw-Alonzo, Red de Varamientos, Yucatan (Ch. 2, 6); James Barnett, British Divers Marine Life Rescue, London, UK (Ch...diagnosed in free-ranging ringed seals" at a time when persistent ice interfered with food production. Nutritional stress also has been implicated in...emergency treatment, nutrition , surgery, quarantine, chronic care, and raising orphaned pups. Some operations continue around the clock. It also serves as a

The Effect of U.S. National Interests on Arms Transfer Decision Making in Brazil.

DTIC Science & Technology

1983-09-01

the assistance of Diana H. bichman, U.S.e , (Wahngt" CI - -n4PrIr. stitute foPubl~c Policy, Res;arc-h, 1982). 4. Geoffrey Kump with Steve Miller, "The...LL.U,, (C]hto S.F~IFFn Uversif. Vr;-s’- TtMB’. 36. Cesar A. Chelala, and Jose F. Westerkamp , "Perilous Irgentine Rearming," N41 121t 122js, June 15

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). Media Ethics Division.

ERIC Educational Resources Information Center

2002

The Media Ethics division of the proceedings contains the following 6 papers: "A Masochist's Teapot: Where to Put the Handle in Media Ethics" (Thomas W. Hickey); "Stalker-razzi and Sump-pump Hoses: The Role of the Media in the Death of Princess Diana" (Elizabeth Blanks Hindman); "The Promise and Peril of Anecdotes in News…

Maximizing Intelligence Sharing Within the Los Angeles Police Department

DTIC Science & Technology

2013-09-01

p. 31). 13 one set of rules the gangs’ rules, and their loyalty is usually first and foremost to the group itself, not the city or country in...evaporating distinctions between the groups as the following compelling example demonstrates. Diana Dean, a U.S. Customs Inspector working Port...to flee the location but was pursued by three agents. The customs officials thought they were dealing with a drug smuggler. However, the lone

Calculation of positron binding energies using the generalized any particle propagator theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero, Jonathan; Charry, Jorge A.; Flores-Moreno, Roberto

2014-09-21

We recently extended the electron propagator theory to any type of quantum species based in the framework of the Any-Particle Molecular Orbital (APMO) approach [J. Romero, E. Posada, R. Flores-Moreno, and A. Reyes, J. Chem. Phys. 137, 074105 (2012)]. The generalized any particle molecular orbital propagator theory (APMO/PT) was implemented in its quasiparticle second order version in the LOWDIN code and was applied to calculate nuclear quantum effects in electron binding energies and proton binding energies in molecular systems [M. Díaz-Tinoco, J. Romero, J. V. Ortiz, A. Reyes, and R. Flores-Moreno, J. Chem. Phys. 138, 194108 (2013)]. In this work,more » we present the derivation of third order quasiparticle APMO/PT methods and we apply them to calculate positron binding energies (PBEs) of atoms and molecules. We calculated the PBEs of anions and some diatomic molecules using the second order, third order, and renormalized third order quasiparticle APMO/PT approaches and compared our results with those previously calculated employing configuration interaction (CI), explicitly correlated and quantum Montecarlo methodologies. We found that renormalized APMO/PT methods can achieve accuracies of ∼0.35 eV for anionic systems, compared to Full-CI results, and provide a quantitative description of positron binding to anionic and highly polar species. Third order APMO/PT approaches display considerable potential to study positron binding to large molecules because of the fifth power scaling with respect to the number of basis sets. In this regard, we present additional PBE calculations of some small polar organic molecules, amino acids and DNA nucleobases. We complement our numerical assessment with formal and numerical analyses of the treatment of electron-positron correlation within the quasiparticle propagator approach.« less

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Jazz pianist and singer Diana Krall holds a montage given to her by the STS-125 space shuttle crew along with Apollo 11 Astronaut Neil Armstrong at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. From left, Michael J. Massimino, Michael T. Good, Gregory C. Johnson, Andrew J. Feustel, Krall, Scott D. Altman, Neil Armstrong, John M. Grunsfeld and Megan McArthur. Photo Credit: (NASA/Bill Ingalls)

Governing Geoengineering Research: A Political and Technical Vulnerability Analysis of Potential Near-Term Options

DTIC Science & Technology

2011-01-01

weather events, or the spread of tropical diseases into North America. The net A Vulnerability-and-Response-Option Analysis Framework for a Risk...Avoidable Surprises, Cambridge: Cambridge University Press, 2002. Doney, Scott C., Victoria J. Fabry , Richard A. Feely, and Joan A. Kleypas, “Ocean...Falkenmark, Louise Karlberg, Robert W. Corell, Victoria J. Fabry , James Hansen, Brian Walker, Diana Liverman, Katherine Richardson, Paul Crutzen, and

Measurements of Positronium Formation Cross Sections for Positron-Kr, Xe Scattering

NASA Astrophysics Data System (ADS)

Kauppila, W. E.; Kwan, C. K.; Li, H.; Stein, T. S.; Zhou, S.

1997-04-01

Our experimental approach(S. Zhou et al., Phys. Rev. Lett. 73, 236 (1994).) for measuring Ps formation cross sections (Q_Ps) involves passing a variable energy positron beam through a gas scattering cell and detecting the 511 keV annihilation gamma rays resulting from the decay of para-Ps and from the interaction of ortho-Ps with the walls of the scattering cell. It is found that the Q_Ps curves for both Kr and Xe rise rapidly from their formation threshold energies of 7.2 and 5.3 eV, reach maxima within about 10 eV of their thresholds and then decrease to become rather small (less than 10% of the peak heights) above 100 eV. At the maxima Q_Ps accounts for more than 50% of the total scattering cross sections. There is some evidence of possible small scale structure in the Q_Ps curves between 10 and 100 eV. The present results are consistent with the prior measurements of Diana et al.( L.M. Diana et al., in "Atomic Physics with Positrons", edited by J.W. Humberston and E.A.G. Armour (Plenum, New York and London, 1987), p. 55; and in "Positron Annihilation", edited by L. Dorikens-Vanpraet et al. (World Scientific, Singapore, 1989), p. 311.) from near threshold to 70 eV for Kr and from 15 to 100 eV for Xe.

Comment on “The two dimensional motion of a particle in an inverse square potential: Classical and quantum aspects” [J. Math. Phys. 54, 053509 (2013)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bietenholz, Wolfgang, E-mail: wolbi@nucleares.unam.mx; Chryssomalakos, Chryssomalis, E-mail: chryss@nucleares.unam.mx; Salgado, Marcelo, E-mail: marcelo@nucleares.unam.mx

We comment on a fatal flaw in the analysis contained in the work of Martínez-y-Romero et al., [J. Math. Phys. 54, 053509 (2013)], which concerns the motion of a point particle in an inverse square potential, and show that most conclusions reached there are wrong. In particular, the manifestly senseless claim that, in the attractive potential case, no bounded orbits exist for negative energies, is traced to a sign error. Several more mistakes, both in the classical and the quantum cases, are pointed out.

Technical Reference Manual to Allied Medical Publication 7.5 (AMedP 7.5) NATO Planning Guide for the Estimation of CBRN Casualties

DTIC Science & Technology

2016-10-01

Response Subject Matter Expert Review Meeting, 23-25 June 2008, Albuquerque, New Mexico , United States of America, IDA Document D-3884 (Alexandria, VA...Meeting, 26 June 2008, Albuquerque, New Mexico , United States of America, IDA Document D-3885 (Alexandria, VA: Institute for Defense Analyses, August...26 June 2008 radiological human response meetings in Albuquerque, New Mexico :  Canada – Commander Ian Torrie, CFHSG-DHSO – Diana Wilkinson, DRDC

Spring Research Festival and NICBR Collaboration Winners Announced | Poster

Cancer.gov

By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria Kaltcheva, Wojciech Kasprzak, Balamurugan Kuppusamy, James Lautenberger, George Lountos, Megan Mounts, Uma Mudunuri, Martha Sklavos, Gloriana Shelton, Alex Sorum, and Shea Wright.

The narrow pentaquark

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diakonov, Dmitri

2007-02-27

The experimental status of the pentaquark searches is briefly reviewed. Recent null results by the CLAS collaboration are commented, and new strong evidence of a very narrow {theta}+ resonance by the DIANA collaboration is presented. On the theory side, I revisit the argument against the existence of the pentaquark - that of Callan and Klebanov - and show that actually a strong resonance is predicted in that approach, however its width is grossly overestimated. A recent calculation gives 2 MeV for the pentaquark width, and this number is probably still an upper bound.

High Frequency Data Acquisition System for Modelling the Impact of Visitors on the Thermo-Hygrometric Conditions of Archaeological Sites: A Casa di Diana (Ostia Antica, Italy) Case Study.

PubMed

Merello, Paloma; García-Diego, Fernando-Juan; Beltrán, Pedro; Scatigno, Claudia

2018-01-25

The characterization of the microclimatic conditions is fundamental for the preventive conservation of archaeological sites. In this context, the identification of the factors that influence the thermo-hygrometric equilibrium is key to determine the causes of cultural heritage deterioration. In this work, a characterization of the thermo-hygrometric conditions of Casa di Diana (Ostia Antica, Italy) is carried out analyzing the data of temperature and relative humidity recorded by a system of sensors with high monitoring frequency. Sensors are installed in parallel, calibrated and synchronized with a microcontroller. A data set of 793,620 data, arranged in a matrix with 66,135 rows and 12 columns, was used. Furthermore, the influence of human impact (visitors) is evaluated through a multiple linear regression model and a logistic regression model. The visitors do not affect the environmental humidity as it is very high and constant all the year. The results show a significant influence of the visitors in the upset of the thermal balance. When a tourist guide takes place, the probability that the hourly temperature variation reaches values higher than its monthly average is 10.64 times higher than it remains equal or less to its monthly average. The analysis of the regression residuals shows the influence of outdoor climatic variables in the thermal balance, such as solar radiation or ventilation.

Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d’Ivoire

PubMed Central

Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N’goran, Eliezer Kouakou; Candolfi, Ermanno

2015-01-01

Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d’Ivoire’s Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. PMID:25619957

High Frequency Data Acquisition System for Modelling the Impact of Visitors on the Thermo-Hygrometric Conditions of Archaeological Sites: A Casa di Diana (Ostia Antica, Italy) Case Study

PubMed Central

Merello, Paloma; García-Diego, Fernando-Juan; Beltrán, Pedro; Scatigno, Claudia

2018-01-01

The characterization of the microclimatic conditions is fundamental for the preventive conservation of archaeological sites. In this context, the identification of the factors that influence the thermo-hygrometric equilibrium is key to determine the causes of cultural heritage deterioration. In this work, a characterization of the thermo-hygrometric conditions of Casa di Diana (Ostia Antica, Italy) is carried out analyzing the data of temperature and relative humidity recorded by a system of sensors with high monitoring frequency. Sensors are installed in parallel, calibrated and synchronized with a microcontroller. A data set of 793,620 data, arranged in a matrix with 66,135 rows and 12 columns, was used. Furthermore, the influence of human impact (visitors) is evaluated through a multiple linear regression model and a logistic regression model. The visitors do not affect the environmental humidity as it is very high and constant all the year. The results show a significant influence of the visitors in the upset of the thermal balance. When a tourist guide takes place, the probability that the hourly temperature variation reaches values higher than its monthly average is 10.64 times higher than it remains equal or less to its monthly average. The analysis of the regression residuals shows the influence of outdoor climatic variables in the thermal balance, such as solar radiation or ventilation. PMID:29370142

Systems analysis identifies miR-29b regulation of invasiveness in melanoma.

PubMed

Andrews, Miles C; Cursons, Joseph; Hurley, Daniel G; Anaka, Matthew; Cebon, Jonathan S; Behren, Andreas; Crampin, Edmund J

2016-11-16

In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple mRNA transcripts, inducing regulated changes across large sets of genes. The miR-target databases TargetScan and DIANA-microT predict putative relationships by examining sequence complementarity between miRs and mRNAs. However, it remains a challenge to identify which miR-mRNA interactions are active at endogenous expression levels, and of biological consequence. We developed a workflow to integrate TargetScan and DIANA-microT predictions into the analysis of data-driven associations calculated from transcript abundance (RNASeq) data, specifically the mutual information and Pearson's correlation metrics. We use this workflow to identify putative relationships of miR-mediated mRNA repression with strong support from both lines of evidence. Applying this approach systematically to a large, published collection of unique melanoma cell lines - the Ludwig Melbourne melanoma (LM-MEL) cell line panel - we identified putative miR-mRNA interactions that may contribute to invasiveness. This guided the selection of interactions of interest for further in vitro validation studies. Several miR-mRNA regulatory relationships supported by TargetScan and DIANA-microT demonstrated differential activity across cell lines of varying matrigel invasiveness. Strong negative statistical associations for these putative regulatory relationships were consistent with target mRNA inhibition by the miR, and suggest that differential activity of such miR-mRNA relationships contribute to differences in melanoma invasiveness. Many of these relationships were reflected across the skin cutaneous melanoma TCGA dataset, indicating that these observations also show graded activity across clinical samples. Several of these miRs are implicated in cancer progression (miR-211, -340, -125b, -221, and -29b). The specific role for miR-29b-3p in melanoma has not been well studied. We experimentally validated the predicted miR-29b-3p regulation of LAMC1 and PPIC and LASP1, and show that dysregulation of miR-29b-3p or these mRNA targets can influence cellular invasiveness in vitro. This analytic strategy provides a comprehensive, systems-level approach to identify miR-mRNA regulation in high-throughput cancer data, identifies novel putative interactions with functional phenotypic relevance, and can be used to direct experimental resources for subsequent experimental validation. Computational scripts are available: http://github.com/uomsystemsbiology/LMMEL-miR-miner.

The Role of “Vortical” Hot Towers in the Formation of Tropical Cyclone Diana (1984).

NASA Astrophysics Data System (ADS)

Hendricks, Eric A.; Montgomery, Michael T.; Davis, Christopher A.

2004-06-01

A high-resolution (3-km horizontal grid spacing) near-cloud-resolving numerical simulation of the formation of Hurricane Diana (1984) is used to examine the contribution of deep convective processes to tropical cyclone formation. This study is focused on the 3-km horizontal grid spacing simulation because this simulation was previously found to furnish an accurate forecast of the later stages of the observed storm life cycle. The numerical simulation reveals the presence of vortical hot towers, or cores of deep cumulonimbus convection possessing strong vertical vorticity, that arise from buoyancy-induced stretching of local absolute vertical vorticity in a vorticity-rich prehurricane environment.At near-cloud-resolving scales, these vortical hot towers are the preferred mode of convection. They are demonstrated to be the most important influence to the formation of the tropical storm via a two-stage evolutionary process: (i) preconditioning of the local environment via diabatic production of multiple small-scale lower-tropospheric cyclonic potential vorticity (PV) anomalies, and (ii) multiple mergers and axisymmetrization of these low-level PV anomalies. The local warm-core formation and tangential momentum spinup are shown to be dominated by the organizational process of the diabatically generated PV anomalies; the former process being accomplished by the strong vertical vorticity in the hot tower cores, which effectively traps the latent heat from moist convection. In addition to the organizational process of the PV anomalies, the cyclogenesis is enhanced by the aggregate diabatic heating associated with the vortical hot towers, which produces a net influx of low-level mean angular momentum throughout the genesis.Simpler models are examined to elucidate the underlying dynamics of tropical cyclogenesis in this case study. Using the Sawyer Eliassen balanced vortex model to diagnose the macroscale evolution, the cyclogenesis of Diana is demonstrated to proceed in approximate gradient and hydrostatic balance at many instances, where local radial and vertical accelerations are small. Using a shallow water primitive equation model, a characteristic “moist” (diabatic) vortex merger in the cloud-resolving numerical simulation is captured in a large part by the barotropic model. Since a moist merger results in a stronger vortex and occurs twice as fast as a dry merger, it is inferred (consistent with related work) that a net low-level convergence can accelerate and intensify the merger process in the real atmosphere.Although the findings reported herein are based on a sole case study and thus cannot yet be generalized, it is believed the results are sufficiently interesting to warrant further idealized simulations of this nature.

Recent Progress in GW-based Methods for Excited-State Calculations of Reduced Dimensional Systems

NASA Astrophysics Data System (ADS)

da Jornada, Felipe H.

2015-03-01

Ab initio calculations of excited-state phenomena within the GW and GW-Bethe-Salpeter equation (GW-BSE) approaches allow one to accurately study the electronic and optical properties of various materials, including systems with reduced dimensionality. However, several challenges arise when dealing with complicated nanostructures where the electronic screening is strongly spatially and directionally dependent. In this talk, we discuss some recent developments to address these issues. First, we turn to the slow convergence of quasiparticle energies and exciton binding energies with respect to k-point sampling. This is very effectively dealt with using a new hybrid sampling scheme, which results in savings of several orders of magnitude in computation time. A new ab initio method is also developed to incorporate substrate screening into GW and GW-BSE calculations. These two methods have been applied to mono- and few-layer MoSe2, and yielded strong environmental dependent behaviors in good agreement with experiment. Other issues that arise in confined systems and materials with reduced dimensionality, such as the effect of the Tamm-Dancoff approximation to GW-BSE, and the calculation of non-radiative exciton lifetime, are also addressed. These developments have been efficiently implemented and successfully applied to real systems in an ab initio framework using the BerkeleyGW package. I would like to acknowledge collaborations with Diana Y. Qiu, Steven G. Louie, Meiyue Shao, Chao Yang, and the experimental groups of M. Crommie and F. Wang. This work was supported by Department of Energy under Contract No. DE-AC02-05CH11231 and by National Science Foundation under Grant No. DMR10-1006184.

The Perseids Aug 11-12, 1996 in Bulgaria

NASA Astrophysics Data System (ADS)

Bojurova, E.; Trukchev, I.

As every year Astroclub "Canopus" organized an extended Perseid observing campaign. Members of the club took part in expedition to Avren village near Varna, at the National Astronomical Observatory (Rojen) and at the National Yought Astronomical Camp in Belite Brezi (South Bulgaria). Here we present some results derived on the basis of data obtained by Biliana Ognianova, Diana Tisheva, Diliana Antonova, Eva Bojurova, Elena Surbinska, Irena Stavreva, Katia Koleva, Lilia Porojanova, Anton Antonov, Denis Mechmedov, Doichin Docinski, Galin Genchev, Ivan Trukhchev, Valentin Velkov. More than 2000 Perseids were recorded. Some other showers were also observed.

Bloodmeal Identification by Direct Enzyme-Linked Immunosorbent Assay (ELISA), Tested on Anopheles (Diptera: Culicidae) in Kenya

DTIC Science & Technology

1988-01-01

8217 RO13ERT A. WIRTZ,’ JOSEPH KOROS, DIANA DLGGS,t THOMAS P. GARGAN 11, AMD DAVY K . KOECH Biomedical Sciences Research Centre, Kenya Medical Research...Sinirlar tests Al 0.01 -11 phosphate buffered saline (1 13S), 1)11 7 4. were run on niinai-fed imosquritoes killed 2 Ii after was addoedi. Samples...esiccator foir mioire thlar I Tween 20. The b~oiledl ciuscif was prepairedl b\\ dis- \\\\ k at( roomni errnwrat rrre. After grininrg iii 5t0 Ml solv ing 5, g

Energy Trapping, Release, and Transport in Three-Dimensional Energetic Solids and Molecular Crystals: Theory of Defects and Impurities.

DTIC Science & Technology

1984-12-31

and 3. T. Waber, Concerning the Trapping of Positrons in Ionic Solids, in Positron Annihilation , P. G. Coleman, S. C. Sharma and L. M. Diana, Eds., 682...1982). *144. A. B. Kunz and 3. T. Waber, A Theoretical Study of the Binding of Positrons to Gaseous Molecules, in Positron Annihilation . P. G. Coleman, S...variety of other cases which include systems in unusual charge states such as Fe + in SrTiOz or Fe in MgO . Impurity systems in their excited states are

An Integrated Science-based methodology

EPA Pesticide Factsheets

The data is secondary in nature. Meaning that no data was generated as part of this review effort. Rather, data that was available in the peer-reviewed literature was used.This dataset is associated with the following publication:Tolaymat , T., A. El Badawy, R. Sequeira, and A. Genaidy. An integrated science-based methodology to assess potential risks and implications of engineered nanomaterials. Diana Aga, Wonyong Choi, Andrew Daugulis, Gianluca Li Puma, Gerasimos Lyberatos, and Joo Hwa Tay JOURNAL OF HAZARDOUS MATERIALS. Elsevier Science Ltd, New York, NY, USA, 298: 270-281, (2015).

Interpretation of the Theta+ as an isotensor pentaquark with weakly decaying partners

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simon Capstick; Philip R. Page; Winston Roberts

2003-09-25

The {Theta}{sup +}(1540), recently observed at LEPS, DIANA and CLAS, is hypothesized to be an isotensor resonance. This implies the existence of a multiplet where the {Theta}{sup ++}, {Theta}{sup +} and {Theta}{sup 0} have isospin-violating strong decays, and the {Theta}{sup +++} and {Theta}{sup -} have weak decays and so are long-lived. Production mechanisms for these states are discussed. The J{sup P} assignment of the {Theta} is most likely 1/2{sup -} or 3/2{sup -} or 5/2{sup -}.

Operations CROSSTIE and BOWLINE Events DOOR MIST, DORSAL FIN, MILK SHAKE, DIANA MOON, HUDSON SEAL, and MING VASE, 31 August 1967 - 20 November 1968

DTIC Science & Technology

1985-12-15

sponsored underground test events were conducted from 31 August 1967 to 20 November 1968 to study weapons effects . Two were shaft-type and four were...conducted, 161 were for weapons related or effects purposes, and 33 were safety ex- periments. An additional 22 nuclear experiments were conducted from...1962 until the last atmospheric test on 4 November 1962, 40 weapons related and weapons effects tests were conducted as part of the Pacific and Nevada

Operations MANDREL and GROMMET Events MINUTE STEAK, DIESEL TRAIN, DIANA MIST, MINT LEAF, HUDSON MOON, DIAGONAL LINE, and MISTY NORTH, 12 September 1969 to 2 May 1972

DTIC Science & Technology

1987-01-30

conducted from 12 September 1969 to 2 May 1972 to study weapons effects . Two were shaft-type and five were tunnel- type nuclear tests. The following table...1958. Of the 194 nuclear device tests conducted, 161 were for weapons related or effects purposes, and 33 were safety ex- periments. An additional 22...States atmospheric testing on 25 April 1962 until the last atmospheric test on 4 November 1962, 40 weapons related and weapons effects tests were

Cohesive zone model for intergranular slow crack growth in ceramics: influence of the process and the microstructure

NASA Astrophysics Data System (ADS)

Romero de la Osa, M.; Estevez, R.; Olagnon, C.; Chevalier, J.; Tallaron, C.

2011-10-01

Ceramic polycrystals are prone to slow crack growth (SCG) which is stress and environmentally assisted, similarly to observations reported for silica glasses. The kinetics of fracture are known to be dependent on the load level, the temperature and the relative humidity. In addition, evidence is available on the influence of the microstructure on the SCG rate with an increase in the crack velocity with decreasing the grain size. Crack propagation takes place beyond a load threshold, which is grain size dependent. We present a cohesive zone model for the intergranular failure process. The methodology accounts for an intrinsic opening that governs the length of the cohesive zone and allows the investigation of grain size effects. A rate and temperature-dependent cohesive model is proposed (Romero de la Osa M, Estevez R et al 2009 J. Mech. Adv. Mater. Struct. 16 623-31) to mimic the reaction-rupture mechanism. The formulation is inspired by Michalske and Freiman's picture (Michalske and Freiman 1983 J. Am. Ceram. Soc. 66 284-8) together with a recent study by Zhu et al (2005 J. Mech. Phys. Solids 53 1597-623) of the reaction-rupture mechanism. The present investigation extends a previous work (Romero de la Osa et al 2009 Int. J. Fracture 158 157-67) in which the problem is formulated. Here, we explore the influence of the microstructure in terms of grain size, their elastic properties and residual thermal stresses originating from the cooling from the sintering temperature down to ambient conditions. Their influence on SCG for static loadings is reported and the predictions compared with experimental trends. We show that the initial stress state is responsible for the grain size dependence reported experimentally for SCG. Furthermore, the account for the initial stresses enables the prediction of a load threshold below which no crack growth is observed: a crack arrest takes place when the crack path meets a region in compression.

Persistent Females and Compliant Males Coordinate Alarm Calling in Diana Monkeys.

PubMed

Stephan, Claudia; Zuberbühler, Klaus

2016-11-07

Sexual dimorphisms in animal vocal behavior have been successfully explained by sexual selection theory (e.g., mammals [1-5]; birds [6, 7]; anurans [8, 9]), but this does not usually include alarm calls, which are thought to be the product of kin or individual selection (e.g., [10, 11]). Here, we present the results of playback experiments with wild Diana monkeys, a species with highly dimorphic predator-specific alarms, to investigate the communication strategies of males and females during predator encounters. First, we simulated predator presence by broadcasting vocalizations of their main predators, leopards or eagles. We found that males only produced predator-specific alarms after the females had produced theirs, in response to which the females ceased alarm calling. In a second experiment, we created congruent and incongruent situations, so that the calls of a predator were followed by playbacks of male or female alarms with a matching or mismatching referent. For congruent conditions, results were the same as in the first experiment. For incongruent conditions, however, the males always gave predator-specific alarms that referentially matched the females' calls, regardless of the previously displayed predator. In contrast, females always gave predator-specific alarms that matched the predator type, regardless of their own male's subsequent calls. Moreover, the females persistently continued to alarm call until their own male produced calls with the matching referent. Results show that males and females attend to the informational content of each other's alarm calls but prioritize them differently relative to an experienced external event, a likely reflection of different underlying selection pressures. Copyright © 2016 Elsevier Ltd. All rights reserved.

Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d'Ivoire.

PubMed

Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N'goran, Eliezer Kouakou; Candolfi, Ermanno

2015-01-01

Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d'Ivoire's Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. © R.W.Y. Kouassi et al., published by EDP Sciences, 2015.

[Opinion from physicians on the need for dyslipidemia screening in cardiovascular risk. Similarities and differences between primary care and other specialties. The DIANA study].

PubMed

Serrano, Adalberto; Pascual, Vicente

2017-10-01

The clinical inertia in the screening and treatment of patients at high or very high cardiovascular risk leads to the failure to achieve LDLc targets in this population. The aim of the DIANA study was to determine the opinion of doctors about the screening for dyslipidaemia, the usual practice, and the differences between Primary Care physicians and other specialties. A questionnaire, using the modified Delphi method, included four blocks on dyslipidemic patients with impaired glucose metabolism. Of the 497 participating experts, 58% were Primary Care physicians. There was agreement on the need for dyslipidemia screening in patients with diabetes, ischaemic heart disease or hypertension, although to a lesser extent among Primary Care physicians. Greater significant differences were found in situations such as pre-diabetes or family history of premature cardiovascular disease (86.2% and 88.6% in Primary Care physicians versus 96.1% and 97.6% in other specialties, respectively). There was no agreement on the need for screening in the presence of xanthomas, xanthelasmas or corneal arcus in people under the age of 45 years, with statistically significant differences in the latter. Dyslipidaemia screening is mainly performed on patients with cardiovascular disease or any major cardiovascular risk factor, and cutaneous lesions of familial hypercholesterolaemia are underestimated. The need for accurate screening and treatment of dyslipidemia in subjects at high cardiovascular risk must be stressed. Copyright © 2016 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

[Central online quality assurance in radiology: an IT solution exemplified by the German Breast Cancer Screening Program].

PubMed

Czwoydzinski, J; Girnus, R; Sommer, A; Heindel, W; Lenzen, H

2011-09-01

Physical-technical quality assurance is one of the essential tasks of the National Reference Centers in the German Breast Cancer Screening Program. For this purpose the mammography units are required to transfer the measured values of the constancy tests on a daily basis and all phantom images created for this purpose on a weekly basis to the reference centers. This is a serious logistical challenge. To meet these requirements, we developed an innovative software tool. By the end of 2005, we had already developed web-based software (MammoControl) allowing the transmission of constancy test results via entry forms. For automatic analysis and transmission of the phantom images, we then introduced an extension (MammoControl DIANA). This was based on Java, Java Web Start, the NetBeans Rich Client Platform, the Pixelmed Java DICOM Toolkit and the ImageJ library. MammoControl DIANA was designed to run locally in the mammography units. This allows automated on-site image analysis. Both results and compressed images can then be transmitted to the reference center. We developed analysis modules for the daily and monthly consistency tests and additionally for a homogeneity test. The software we developed facilitates the immediate availability of measurement results, phantom images, and DICOM header data in all reference centers. This allows both targeted guidance and short response time in the case of errors. We achieved a consistent IT-based evaluation with standardized tools for the entire screening program in Germany. © Georg Thieme Verlag KG Stuttgart · New York.

Retraction: Borroto-Escuela et al., The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.

PubMed

2013-07-10

The Journal of Neuroscience has received a report describing an investigation by the Karolinska Institutet, which found substantial data misrepresentation in the article "The Existence of FGFR1-5-HT1A Receptor Heterocomplexes in Midbrain 5-HT Neurons of the Rat: Relevance for Neuroplasticity" by Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O. Tarakanov, Giuseppa Mudó , Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, and Kjell Fuxe, which appeared on pages 6295-6303 of the May 2, 2012 issue. Because the results cannot be considered reliable, the editors of The Journal are retracting the paper.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butt, Y M; Romero, G E; Torres, D F

We suggest that ultraluminous X-ray sources (ULXs) and some of the variable low latitude EGRET gamma-ray sources may be two different manifestations of the same underlying phenomena: high-mass microquasars with relativistic jets forming a small angle with the line of sight (i.e. microblazars). Microblazars with jets formed by relatively cool plasma (Lorentz factors for the leptons up to a few hundreds) naturally lead to ULXs. If the jet contains very energetic particles (high-energy cutoff above Lorentz factors of several thousands) the result is a relatively strong gamma-ray source. As pointed out by Kaufman Bernads, Romero & Mirabel (2002), a gamma-raymore » microblazar will always have an X-ray counterpart (although it might be relatively weak), whereas X-ray microblazars might have no gamma-ray counterparts.« less

Minor planets and related objects. XXI - Photometry of eight asteroids

NASA Technical Reports Server (NTRS)

Taylor, R. C.; Gehrels, T.; Capen, R. C.

1976-01-01

Light curves, UBV colors, rotational periods, phase coefficients, and absolute magnitudes are presented. The asteroids studied are (1) Ceres, (4) Vesta, (16) Psyche, (78) Diana, (281) Lucretia, (451) Patientia, (1212) Francette, and (1362) Griqua. The rotation axis of Lucretia is nearly perpendicular to the plane of the ecliptic. Ceres appears to be nearly spherical with an absolute magnitude of B(1,0)=4.42, which is 0.3 mag fainter than previously reported. The determination of the absolute magnitude for an asteroid depends on its aspect, and for each opposition there is, therefore, a different absolute magnitude.

Geologic framework and hydrogeologic characteristics in the southern part of the Rancho Diana Natural Area, northern Bexar County, Texas, 2008-10

USGS Publications Warehouse

Clark, Allan K.; Morris, Robert R.

2011-01-01

The area designated by the city of San Antonio as the Rancho Diana Natural Area is in northern Bexar County, near San Antonio, Texas. During 2008-10, the U.S. Geological Survey, in cooperation with the city of San Antonio, documented the geologic framework and mapped the hydrogeologic characteristics for the southern part of the Rancho Diana Natural Area. The geologic framework of the study area and its hydrogeologic characteristics were documented using field observations and information from previously published reports. Many of the geologic and hydrogeologic features were found by making field observations through the dense vegetation along gridlines spaced approximately 25 feet apart and documenting the features as they were located. Surface geologic features were identified and hydrogeologic features such as caves, sinkholes, and areas of solutionally enlarged porosity were located using hand-held Global Positioning System units. The location data were used to create a map of the hydrogeologic subdivisions and the location of karst features. The outcrops of the Edwards and Trinity aquifer recharge zones were mapped by using hydrogeologic subdivisions modified from previous reports. All rocks exposed within the study area are of sedimentary origin and Lower Cretaceous in age. The valley floor is formed in the cavernous member of the upper Glen Rose Limestone of the Trinity Group. The hills are composed of the basal nodular member, dolomitic member, Kirschberg evaporite member, and grainstone member of the Kainer Formation of the Edwards Group. Field observations made during this study of the exposed formations and members indicate that the formations and members typically are composed of mudstones, wackestones, packstones, grainstones, and argillaceous limestones, along with marls. The upper Glen Rose Limestone is approximately 410 to 450 feet thick but only the upper 70 feet is exposed in the study area. The Kainer Formation is approximately 255 feet thick in the study area and is composed of, in ascending order, the basal nodular member, dolomitic member, Kirschberg evaporite member, and grainstone member. The Edwards and Trinity aquifers contain a combination of fabric-selective and not-fabric-selective porosities. Porosity types observed in the study area that can increase the effective porosity and increase permeability include solutionally enlarged caves, sinkholes, fractures, bedding planes, channels, molds and vugs. Caves found during hydrogeologic mapping might have been spring discharge points, but sufficient downcutting over geologic time in the rocks has occurred so that springs discharge at lower elevations near the creek channel. The mapped caves, sinkholes, and other areas of solutionally enlarged porosity might facilitate recharge during large storm events when runoff occurs on the hillsides; additional areally distributed recharge in the study area occurs as a result of infiltration.

Analysing surface runoff and erosion responses to different land uses from the NE of Iberian Peninsula through rainfall simulation

NASA Astrophysics Data System (ADS)

Regüés, David; Arnáez, José; Badía, David; Cerdà, Artemi; Echeverría, María Teresa; Gispert, María; Lana-Renault, Noemí; Lasanta, Teodoro; León, Javier; Nadal-Romero, Estela; Pardini, Giovanni

2014-05-01

Rainfall simulation experiments are being used by soil scientists, geomorphologists, and hydrologist to study runoff generation and erosion processes. The use of different apparatus with different rainfall intensities and size of the wetted area contribute to determine the most vulnerable soils and land uses (Cerdá, 1998; Cerdà et al., 2009; Nadal-Romero et al., 2011; Martínez-Murillo et al., 2013; León et al., 2014). This research aims to determine the land uses that yield more sediments and water and to know the factors that control the differences. The information from 152 experiments of rainfall simulation was jointly analysed. Experiments were done in 17 land uses (natural forest, tree plantation, burned forest, scrub, meadows, crops and badlands), with contrasted exposition (north-south), and vegetation cover variety and/or density. These situations were selected from four geographic contexts (NE of Catalonia, high and medium lands from the Ebro valley and Southern range of central Pyrenees) with significant altitude variations, between 90 and 1000 meters above sea level, which represent the heterogeneity of the Mediterranean climate. The use of similar rainfall simulation apparatus, with the same spray nozzle, spraying components and plot size, favours the comparison of the results. A wide spectrum of precipitation intensities was applied, in order to reach surface runoff generation in all cases. Results showed significant differences in runoff amounts and erosion rates, which were mainly associated with land uses, even more than precipitation differences. Runoff coefficient shows an inversed exponential relationship with rainfall intensity, which is the opposite what could be previously expected (Ziadat and Taimeh, 2013). This may be only justified by land use characteristics because a direct effect between runoff generation intensity and soil degradation conditions, with respect vegetation covers features and density, was observed. In fact, even though the highest rainfall intensities were applied in the most natural areas with a dense vegetation cover, the most intense responses were produced in the most altered environments (badlands, born forest, vineyard, pasture and stony soils). These results agreed with the cause-effect relationships observed in some antecedent studies, which compare the hydrological and erosive response in different land uses (Badía et al., 2008; García-Ruíz et al., 2008; García-Ruíz and Lana-Renault, 2011). This has been mainly associated with variations of soil chemical, physical and hydrological properties (Pardini et al., 2004, Emran et al., 2012; Regüés et al., 2012). Likewise, this analysis has provided comparable information for various contrasted land uses, allowing estimate proportionality factors between them. This information favours the classification of certain environments according to its relative trends to surface runoff and erosion. References Badía, D.; Martí, C.; Aguirre, J., Echeverría, M.T., Ibarra, P. (2008). Erodibility and hydrology of arid burned soils: soil type and revegetation effects. Arid Land Research and Management, 22: 286-295. Cerdà, A. (1998). The influence of aspect and vegetation on seasonal changes in erosion under rainfall simulation on a clay soil in Spain. Canadian Journal of Soil Science 78, 321-330. Cerdà, A., Giménez-Morera, A. y Bodí, M.B. (2009). Soil and water losses from new citrus orchards growing on sloped soils in the western Mediterranean basin. Earth Surface Processes and Landforms 34, 1822-1830. Doi: 10.1002/esp.1889. Emran, M., Gispert, M., Pardini, G. (2012). Comparing measurements method of carbon dioxide fluxes in a soil sequence under land cover change in North Eastern Spain. Geoderma 170, 176-185. Doi. 10.1016/j.geoderma.2011.11.013. García-Ruíz, J.M., Regüés, D., Alvera, B., Lana-Renault, N., Serrano-Muela, P., Nadal-Romero, E., Navas, A., Latron, J., Martí-Bono, C., Arnáez, J. (2008). Flood generation and sediment transport in experimental catchments affectd by land use changes in the central Pyrenees. Journal of Hydrology 359, 245-260. Doi: 10.1016/j.hydrol.2008.04.013. García-Ruíz, J.M. and Lana-Renault, N. (2011): Hydrology and erosive consquences of farmland abandonment in Europe, with special reference to the Mediterranean region-A review. Agriculture, Ecosystems and Environment 140, 317-338. Doi: 10.1016/j.agee.2011.01.003. León, J., Cerdà, A., Seeger, M., Badía, D. (2014). Applications of rainfall simulators to study areas affected by forest fires. Flamma 5 (3), 116-120. Nadal-Romero, E., Lasanta, T., Regüés, D., Lana-Renault, N., Cerdá, A. (2011). Hydrological response and sediment production under different land cover ina abandoned farmland fields ina a Mediterranean mountain environment. Boletín de la Asociación de Geógrafos Españoles 55, 303-323. Martínez Murillo, J.F., Nadal-Romero, E., Regüés, D., Cerdá, A., Poesen, J. (2013). Soil erosion and hydrology of the western Mediterranean badlands throughout rainfall simulation experiments: A review. Catena 106, 101-112. Doi: 10.1016/j.catena.2012.06.001. Pardini, G., Gispert, M, Dunjó, G. (2004): Study of soil properties distribution patterns in a rural Mediterranean area of NE Spain. Mountain Research and Development, 24 (1): 44-51. Regüés, D., Serrano-Muela, P., Nadal-Romero, E., Lana-Renault, N. (2012). Análisis de la variabilidad temporal de la infiltración en un gradiente de usos del suelo en el Pirineo central. Cuaternario y Geomorfología 26 (1-2), 9-28. Ziadat F.M. and Taimeh A.Y. (2013). Effect of rainfall intensity, slope, land use and antecedent soil moisture on soil erosion in an arid environment. Land Degradation & Development 24 (6), 582-590. Doi: 10.1002/ldr.2239.

An integrated tool for loop calculations: AITALC

NASA Astrophysics Data System (ADS)

Lorca, Alejandro; Riemann, Tord

2006-01-01

AITALC, a new tool for automating loop calculations in high energy physics, is described. The package creates Fortran code for two-fermion scattering processes automatically, starting from the generation and analysis of the Feynman graphs. We describe the modules of the tool, the intercommunication between them and illustrate its use with three examples. Program summaryTitle of the program:AITALC version 1.2.1 (9 August 2005) Catalogue identifier:ADWO Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWO Program obtainable from:CPC Program Library, Queen's University of Belfast, N. Ireland Computer:PC i386 Operating system:GNU/ LINUX, tested on different distributions SuSE 8.2 to 9.3, Red Hat 7.2, Debian 3.0, Ubuntu 5.04. Also on SOLARIS Programming language used:GNU MAKE, DIANA, FORM, FORTRAN77 Additional programs/libraries used:DIANA 2.35 ( QGRAF 2.0), FORM 3.1, LOOPTOOLS 2.1 ( FF) Memory required to execute with typical data:Up to about 10 MB No. of processors used:1 No. of lines in distributed program, including test data, etc.:40 926 No. of bytes in distributed program, including test data, etc.:371 424 Distribution format:tar gzip file High-speed storage required:from 1.5 to 30 MB, depending on modules present and unfolding of examples Nature of the physical problem:Calculation of differential cross sections for ee annihilation in one-loop approximation. Method of solution:Generation and perturbative analysis of Feynman diagrams with later evaluation of matrix elements and form factors. Restriction of the complexity of the problem:The limit of application is, for the moment, the 2→2 particle reactions in the electro-weak standard model. Typical running time:Few minutes, being highly depending on the complexity of the process and the FORTRAN compiler.

The influence of environmental parameters in the biocolonization of the Mithraeum in the roman masonry of casa di Diana (Ostia Antica, Italy).

PubMed

Scatigno, C; Moricca, C; Tortolini, C; Favero, G

2016-07-01

The microclimatic parameters (Ta, RH, E, and CO2) reflect the indoor quality of the environment. Their relationship, connected with the design of the building, can facilitate the growth of photo/heterotrophic organisms and therefore facilitate the increase of the relative CO2 production. Taking this into account, the impact of biological proliferation in a historical building is discussed for the Mithraeum of "Casa di Diana" in the archaeological site of Ostia Antica, which is subjected to guided tours. In this work, for the first time, we propose a study on biological monitoring to evaluate the contribution of bioactivity to air quality, with the objective to increase the comfort of visitors and to open the site for more than one day per week, suggesting possible tools providing a good compromise between building conservation and human comfort. In the sense, it has been possible to distinguish the contribution of the plants from the one deriving from humans: high values of carbon dioxide have been recorded during the night and its scarce removal during the day (air flow). The window present is not sufficient to eliminate the CO2, involving concentrations of CO2 relatively high in comparison to the proposed limits and guidelines defined by law. The obtained results strongly encouraged the elimination of flora in order to increase the comfort of visitors and to open the house for more than one day per week. Although, this process involves an important economic effort, the present study allows making an objective decision which has an important value in a cultural heritage management. Graphical Abstract CO2 contribute by bioactivity as damage to human health.

Developing a Carbon Observing System

NASA Astrophysics Data System (ADS)

Moore, B., III

2015-12-01

There is a clear need to better understand and predict future climate change, so that science can more confidently inform climate policy, including adaptation planning and future mitigation strategies. Understanding carbon cycle feedbacks, and the relationship between emissions (fossil and land use) and the resulting atmospheric carbon dioxide (CO2) and methane (CH4) concentrations in a changing climate has been recognized as an important goal by the IPCC. The existing surface greenhouse gas observing networks provide accurate and precise measurements of background values, but they are not configured to target the extended, complex and dynamic regions of the carbon budget. Space Agencies around the globe are committed to CO2 and CH4 observations: GOSAT-1/2, OCO-2/3, MERLin, TanSat, and CarbonSat. In addition to these Low Earth Orbit (LEO) missions, a new mission in Geostationary Orbit (GEO), geoCARB, which would provide mapping-like measurements of carbon dioxide, methane, and carbon monoxide concentrations over major land areas, has been recently proposed to the NASA Venture Program. These pioneering missions do not provide the spatial/temporal coverage to answer the key carbon-climate questions at process relevant scales nor do they address the distribution and quantification of anthropogenic sources at urban scales. They do demonstrate, however, that a well-planned future system of system integrating space-based LEO and GEO missions with extensive in situ observations could provide the accuracy, spatial resolution, and coverage needed to address critical open issues in the carbon-climate system. Dr. Diana Wickland devoted enormous energy in developing a comprehensive apprioach to understand the global carbon cycle; she understood well that an integrated, coordinated, international approach is needed. This shines through in her recent contribution in co-chairing the team that produced the "CEOS Strategy for Carbon Observations from Space." A NASA-funded community workshop in March 2015 addressed issues and prioritzed a set of research and observational needs in the study of the Carbon-Climate System. This paper will refect upon the past 30 plus years of carbon research supported by NASA and Dr. Wickland's role, and it will conclude with the findings of the March 2015 Workshop.

Evaluation of one dimensional analytical models for vegetation canopies

NASA Technical Reports Server (NTRS)

Goel, Narendra S.; Kuusk, Andres

1992-01-01

The SAIL model for one-dimensional homogeneous vegetation canopies has been modified to include the specular reflectance and hot spot effects. This modified model and the Nilson-Kuusk model are evaluated by comparing the reflectances given by them against those given by a radiosity-based computer model, Diana, for a set of canopies, characterized by different leaf area index (LAI) and leaf angle distribution (LAD). It is shown that for homogeneous canopies, the analytical models are generally quite accurate in the visible region, but not in the infrared region. For architecturally realistic heterogeneous canopies of the type found in nature, these models fall short. These shortcomings are quantified.

NASA in Silicon Valley Live - Episode 02 - Self-driving Robots, Planes and Automobiles

NASA Image and Video Library

2018-01-26

NASA in Silicon Valley Live is a live show streamed on Twitch.tv that features conversations with the various researchers, scientists, engineers and all around cool people who work at NASA to push the boundaries of innovation. In this episode livestreamed on January 26, 2018, we explore autonomy, or “self-driving” technologies with Terry Fong, NASA chief roboticist, and Diana Acosta, technical lead for autonomous systems and robotics. Video credit: NASA/Ames Research Center NASA's Ames Research Center is located in California's Silicon Valley. Follow us on social media to hear about the latest developments in space, science, technology and aeronautics.

A computer graphics based model for scattering from objects of arbitrary shapes in the optical region

NASA Technical Reports Server (NTRS)

Goel, Narendra S.; Rozehnal, Ivan; Thompson, Richard L.

1991-01-01

A computer-graphics-based model, named DIANA, is presented for generation of objects of arbitrary shape and for calculating bidirectional reflectances and scattering from them, in the visible and infrared region. The computer generation is based on a modified Lindenmayer system approach which makes it possible to generate objects of arbitrary shapes and to simulate their growth, dynamics, and movement. Rendering techniques are used to display an object on a computer screen with appropriate shading and shadowing and to calculate the scattering and reflectance from the object. The technique is illustrated with scattering from canopies of simulated corn plants.

Formation of a narrow baryon resonance with positive strangeness in K{sup +} collisions with Xe nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.

2010-07-15

The data on the charge-exchange reaction K{sup +}Xe {sup {yields}}K{sup 0}pXe', obtained with the bubble chamber DIANA, are reanalyzed using increased statistics and updated selections. Our previous evidence for formation of a narrow pK{sup 0} resonance with mass near 1538 MeV is confirmed. The statistical significance of the signal reaches some 8{sigma} (6{sigma}) standard deviations when estimated as S/{radical}B (S/{radical}B + S. The mass and intrinsic width of the {Theta}{sup +} baryon are measured as m = 1538 {+-} 2 MeV and {Gamma} = 0.39 {+-} 0.10 MeV.

Relation of runoff and soil erosion to weather types in the Mediterranean basin

NASA Astrophysics Data System (ADS)

Nadal-Romero, Estela; Peña-Angulo, Dhais

2017-04-01

Nadal-Romero, E. (1), Peña-Angulo, D. (1), Albaladejo, J. (2), Andreu, V. (3), Bahri, H. (4), Bagarello, V. (5), Batalla, R., (6), Bienes, R. (7), Campo, J. (3), Campo-Bescós, M.A. (8), Canatario, A. (9), Cantón, Y. (10), Casali, J. (8), Castillo, V. (2), Cid, P. (11), Cortesi, N. (12), Desir, G. (13), Díaz, E. (2), Ferreira, C. (14), Ferro, V. (5), Giménez, R. (8), Gimeno, E. (3), Gómez, J.A. (15), Gómez-Gutiérrez, A. (16), González-Hidalgo, J.C. (1), Klotz, S. (17) Kosmas, C. (18), Lana-Renault, N. (19), Lasanta, T. (20), Lázaro, R., (21), Le Bissonnais, Y. (22), Le Bouteiller, C. (17), Licciardello, F. (23), López-Tarazón, J.A. (24), Lucía, A. (25), Marín, C. (13), Marqués, M.J., (26) Martínez-Fernández, J. (27), Martínez-Mena, M. (2), Martínez-Murillo, J.F. (28), Mateos, L. (15), Novara, A. (5), Pachecho, E. (29), Raclot, D. (22), Rodríguez-Blanco, M.L. (30), Romero-Díaz, A. (31), Rubio, J.L. (3), Ruiz-Sinoga, J.D. (28), Schnabel, S. (16), Simonneaux, V. (32), Solé-Benet, A. (21), Taguas, E.V. (33), Taboada-Castro, M.M. (30), Taboada-Casto, M.T. (30), Todisco, F. (34), Úbeda, X. (29), Varouchakis, E. A. (35), Zabaleta, A. (36), Zorn, M. (37) (1) Departamento de Geografía, Instituto Universitario de Ciencias Ambientales (IUCA), Universidad de Zaragoza, Zaragoza, Spain (2) Soil and water conservation research group, CEBAS-CSIC, Murcia, Spain (3) Degradación y conservación de suelos, Centro de Investigación sobre Desertificación (CIDE), Valencia, Spain (4) INRGREF, Tunis, Tunisia (5) Department of Scienze Agrarie e Forestali, University of Palermo, viale delle scienze, Palermo, Italy (6) Department de Medi Ambient, Universitat de Lleida, Lleida, Spain (7) Departamento Investigación Aplicada y Extensión Agraria. Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario (IMIDRA), Madrid, Spain (8) Escuela Técnica Superior de Ingeniería Agrónoma, Universidad Pública de Navarra, Pamplona, Spain (9) Polytechnic Institute of Catelo Branco, School of Agriculture (ESACB), Portugal (10) Departamento de Agronomía, Universidad de Almería, Almería, Spain (11) Center for Research and Advanced Studies of the Nactional Polytechnic Institute, Mexico City, DF, Mexico (12) Centro Nacional de Supercomputacion, Department of Earth Sciences, Barcelona, Spain (13) Departamento de Ciencias de la Tierra, Universidad de Zaragoza, Zaragoza, Spain (14) Centro de Estudos de Recursos Naturais, Ambiente e Sociedade (CERNAS), Coimbra Agrarian Technical School, Polytechnic Institute of Coimbra, Coimbra, Portugal (15) Instituto de Agricultura Sostenible—CSIC, Córdoba, Spain (16) Grupo de Investigación GeoAmbiental (GIGA), Área de Geografía Física, Facultad de Filosofía y Letras. Universidad de Extremadura, Cáceres, Spain (17) Department of Waters, National Research Institute of Science and Technology for Environment and Agriculture, France (18) Department of Natural Resources Management and Agricultural Engineering, Agricultural University of Athens, Athens, Greece (19) Area of Physical Geography, Luis Vives Building, Luis de Ulloa Street, University of La Rioja, 26006 Logroño, Spain (20) Instituto Pirenaico de Ecología, IPE-CSIC, Zaragoza, Spain (21) Estación Experimental de Zonas Áridas, EEZA-CSIC, Almería, Spain (22) IRD, LISAH, Montpellier, France (23) Department of Agri-Food and Environmental Systems Management, University of Catania, Catania, Italy (24) Institute of Earth and Environmental Science, University of Potsdam, Potsdam, Germany (25) Center for Applied Geosciences. Faculty of Science, Eberhard Karls Universität Tübingen, Germany (26) Departamento de Geología y Geoquímica, Universidad Autónoma Madrid, Madrid, Spain (27) Departamento de Geografía, Universidad de Salamanca, Salamanca, Spain (28) Departamento de Geografía, Grupo de Investigación Geografía Física y Territorio—RNM279, Andalucía Tech, Universidad de Málaga, Málaga, Spain (29) Grup de Recerca Ambiental Mediterrània, Departamento de Geografia Física i AGR, Universitat de Barcelona, Spain (30) Facultad de Ciencias and Centro de Investigaciones Científicas Avanzadas (CICA), University of A Coruña, Campus de A Coruña, Spain (31) Departamento de Geografía, Universidad de Murcia, Murcia, Spain (32) French National Research Institut for Sustainable Development (IRD), CESBIO Laboratory, Toulouse, France. (33) Escuela Técnica Superior de Ingeniería Agronómica e I. de Montes, Departamento de Ingeniería Rural, Universidad de Córdoba, Córdoba, Spain (34) Departament of Environmental and Agricultural Sciences, Università degli Studi di Perugia, Perugia, Italy (35) Technical University of Crete, School of Environmental Engineering, Chania, Greece (36) Departamento de Geodinámica, Universidad del País Vasco UPV/EHU, Leioa, Spain (37) Geographical Institute, Research Centre of the Slovenian Academy of Sciences and Arts, Ljubljana, Slovenia Erosion processes and land degradation are recognized as one of the most significant environmental problems worldwide. In the Mediterranean region, intense erosion processes occur as a consequence of complex interactions between environmental conditions (e.g. climate, lithology) and human-related factors (e.g. history of human activity, land use changes) (García-Ruiz et al., 2013). Precipitation has been recognized as one of the main factors driving soil erosion. In climatology, one of the most common approaches in analyzing spatial and temporal precipitation variability is the circulation of weather types (WTs), which categorize the continuum of atmospheric circulation into a small number of classes or types. Flood generation and soil erosion are associated with specific weather conditions. Previous research in the Iberian Peninsula has analyzed the relationship between precipitation and specific WTs, demonstrating that specific WTs are the main drivers of precipitation and soil erosion in the different areas (Cortesi et al., 2014; Nadal-Romero et al., 2015). In this study, we present a preliminary analysis of WTs and runoff and soil erosion data from 50 study areas in the Mediterranean basin including different land uses. To do so,we have collected and jointed different research groups cross the Mediterranean Basin, and combined different databases (plots and small representative catchments) with the WT classification calculated using the NCEP/NCAR 40-Year Reanalysis Project. This pioneer research will be a valuable tool in understanding the relationships between weather types, precipitation and soil erosion dynamics. Acknowledgments Estela Nadal-Romero was the beneficiary of a "Ramón y Cajal" postdoctoral contract (Spanish Ministry of Economy and Competitiveness). José Andrés López-Tarazón is in receipt of a Marie Curie Intra-European Fellowship (Project ''Floodhazards'', PIEF-GA-2013-622468, Seventh EU Framework Programme). References Cortesi, N., González-Hidalgo, J.C., Trigo, R.M., Ramos, A.M., 2014. Weather types and spatial variability of precipitation in the Iberian Peninsula. International Journal of Climatology 34(8), 2661-2677. García-Ruiz, J.M., Nadal-Romero, E., Lana-Renault, N., Beguería, S., 2013. Erosion in Mediterranean landscapes: Changes and future challenges. Geomorphology 198, 20-36. Nadal-Romero, E., González-Hidalgo, J.C., Cortesi, N., Desir, G., Gómez, J.A., et al., 2015. Relationship of runoff, erosion and sediment yield to weather types in the Iberian Peninsula. Geomorphology 228, 372-381.

Bianisotropic-critical-state model to study flux cutting in type-II superconductors at parallel geometry

NASA Astrophysics Data System (ADS)

Romero-Salazar, C.

2016-04-01

A critical-state model is postulated that incorporates, for the first time, the structural anisotropy and flux-line cutting effect in a type-II superconductor. The model is constructed starting from the theoretical scheme of Romero-Salazar and Pérez-Rodríguez to study the anisotropy induced by flux cutting. Here, numerical calculations of the magnetic induction and static magnetization are presented for samples under an alternating magnetic field, orthogonal to a static dc-bias one. The interplay of the two anisotropies is analysed by comparing the numerical results with available experimental data for an yttrium barium copper oxide (YBCO) plate, and a vanadium-titanium (VTi) strip, subjected to a slowly oscillating field {H}y({H}z) in the presence of a static field {H}z({H}y).

A microclimate study on hypogea environments of ancient roman building.

PubMed

Scatigno, C; Gaudenzi, S; Sammartino, M P; Visco, G

2016-10-01

Roman hypogea, vernacular settlements or crypts, are underground places characterised by specific and unique challenges (RH<90% and almost constant temperature throughout the whole year) related to their relative isolation from the outdoor environment. These sites often require adequate monitoring tools providing complete environmental information in order to carry out appropriate strategies for scheduling routine maintenance and designing suitable layouts for their preservation. In this work we present the results of a carefully planned thermo-hygrometric monitoring campaign conducted in a peculiar Roman building (130CE), the "Casa di Diana" Mithraeum, sited in Ostia Antica (archaeological site, Rome-Italy), with the aim of characterising the indoor environment as the structure suffers of several conservation problems (biocolonisation, efflorescences, evaporating and condensing cycle for wall-building materials). The campaign involving multipoint continuous measurement was carefully planned to better describe this micro-clime. In addition to underground environmental data available in literature, we have also performed, as a checkpoint control, a thermo-hygrometric monitoring campaign in the "Terme di Mitra" Hypogeum, a few meters from the "Casa di Diana". The recorded data was analysed by multivariate statistical and chemometric analyses. The results brought to light the presence of different microclimates (three areas) within a single Mithraeum: a room (pre-Mithraeum) and an area (Mithraeum: 2-4m) present a thermo-hygrometric environmental behaviour in accordance with a semi-confined environment, another area (Mithraeum: 1-2m) behaves accordingly with underground environments (although it cannot be described as such), and the last area (Mithraeum: 0-1m) where was recording RH values close to saturation (96-99%), associated with non-ventilated areas where the rising damp is "held" and not dispersed, describing an own micro-clime, comparable to a "small greenhouse". This study has allowed to identify some critical areas in view of planning future conservation solutions, without exporting the artefacts kept inside. Copyright © 2016 Elsevier B.V. All rights reserved.

Tensiometer-Based Irrigation Management of Subirrigated Soilless Tomato: Effects of Substrate Matric Potential Control on Crop Performance

PubMed Central

Montesano, Francesco F.; Serio, Francesco; Mininni, Carlo; Signore, Angelo; Parente, Angelo; Santamaria, Pietro

2015-01-01

Automatic irrigation scheduling based on real-time measurement of soilless substrate water status has been recognized as a promising approach for efficient greenhouse irrigation management. Identification of proper irrigation set points is crucial for optimal crop performance, both in terms of yield and quality, and optimal use of water resources. The objective of the present study was to determine the effects of irrigation management based on matric potential control on growth, plant–water relations, yield, fruit quality traits, and water-use efficiency of subirrigated (through bench system) soilless tomato. Tensiometers were used for automatic irrigation control. Two cultivars, “Kabiria” (cocktail type) and “Diana” (intermediate type), and substrate water potential set-points (−30 and −60 hPa, for “Diana,” and −30, −60, and −90 hPa for “Kabiria”), were compared. Compared with −30 hPa, water stress (corresponding to a −60 hPa irrigation set-point) reduced water consumption (14%), leaf area (18%), specific leaf area (19%), total yield (10%), and mean fruit weight (13%), irrespective of the cultivars. At −60 hPa, leaf-water status of plants, irrespective of the cultivars, showed an osmotic adjustment corresponding to a 9% average osmotic potential decrease. Total yield, mean fruit weight, plant water, and osmotic potential decreased linearly when −30, −60, and −90 hPa irrigation set-points were used in “Kabiria.” Unmarketable yield in “Diana” increased when water stress was imposed (187 vs. 349 g·plant−1, respectively, at −30 and −60 hPa), whereas the opposite effect was observed in “Kabiria,” where marketable yield loss decreased linearly [by 1.05 g·plant−1 per unit of substrate water potential (in the tested range from −30 to −90 hPa)]. In the second cluster, total soluble solids of the fruit and dry matter increased irrespective of the cultivars. In the seventh cluster, in “Diana,” only a slight increase was observed from −30 vs. −60 hPa (3.3 and 1.3%, respectively, for TSS and dry matter), whereas in “Kabiria,” the increase was more pronounced (8.7 and 12.0%, respectively, for TSS and dry matter), and further reduction in matric potential from −60 to −90 hPa confirmed the linear increase for both parameters. Both glucose and fructose concentrations increased linearly in “Kabiria” fruits on decreasing the substrate matric potential, whereas in “Diana,” there was no increase. It is feasible to act on matric potential irrigation set-points to control plant response in terms of fruit quality parameters. Precise control of substrate water status may offer the possibility to steer crop response by enhancing different crop-performance components, namely yield and fruit quality, in subirrigated tomato. Small-sized fruit varieties benefit more from controlled water stress in terms of reduced unmarketable yield loss and fruit quality improvements. PMID:26779189

Nutritive value evaluated on rats of new cultivars of common beans (Phaseolus vulgaris) released in Chile.

PubMed

Yañez, E; Zacarias, I; Aguayo, M; Vasquez, M; Guzman, E

1995-06-01

Five new cultivars of common beans (Phaseolus vulgaris) recently released were analyzed for their proximate chemical composition and protein biological quality. The crude protein content in these cultivars ranged from 21.9 percent in cultivar Arroz 3 to 26.9 percent in cultivar Tórtola Diana (dry matter basis). Rats fed cultivar Tórtola INIA gained more weight, had a higher protein intake and registered higher PER and NPR than Tórtola corriente. On the other hand, rats consuming cultivars Arroz 3 and Fleetwood had lower weight gain, lower protein intake and lower PER and NPR than cultivar Coscorrón corriente. However, all these cultivars have a relatively good protein value as compared to other plant protein sources.

Cassiopeia A: Supernova explosion and expansion simulations under strong asymmetry conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yakhin, R. A., E-mail: yakhin.rafael@gmail.com; Rozanov, V. B.; Zmitrenko, N. V.

We propose a model for the explosion of a supernova and the expansion of its ejecta in the presence of a strong initial asymmetry (at the explosion time) in the central part of the star (core) and a possible smallscale asymmetry in the peripheral regions. The Chandra and NuSTAR observations of ejecta in the Cassiopeia A supernova remnant are analyzed. Based on our 1D and 2D numerical simulations performed using the DIANA and NUTCY codes, we propose a model for the explosion and expansion of ejecta that explains the observed experimental data where the materials initially located in the centralmore » region of the star end up on the periphery of the cloud of ejecta.« less

Mutations Allow JC Polyomaviruses to Elude Antibody Recognition | Center for Cancer Research

Cancer.gov

JC polyomavirus (JCV) infects the urinary tract of most adults. In healthy individuals, JCV infection does not cause noticeable symptoms. However, in those with compromised immune systems, JCV can cause a lethal brain disease called progressive multifocal leukoencephalopathy (PML). Data from a recently approved assay to detect serum antibodies specific for the JCV protein VP1 revealed that patients with antibodies are at increased risk of developing PML. At the same time, sequencing studies of JCV in cerebrospinal fluid (CSF) identified a number of mutations in VP1. Christopher Buck, Ph.D., and Diana Pastrana, Ph.D., of CCR’s Laboratory of Cellular Oncology, and their colleagues hypothesized that the VP1 mutations could allow the virus to evade antibody-mediated elimination.

New Display-type Analyzer for Three-dimensional Fermi Surface Mapping and Atomic Orbital Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takahashi, Nobuaki; Matsuda, Hiroyuki; Shigenai, Shin

2007-01-19

We have developed and installed a new Display-type ANAlyzer (DIANA) at Ritsumeikan SR center BL-7. We measured the angle-integrated energy distribution curve of poly-crystal gold and the photoelectron intensity angular distribution (PIAD) of HOPG to estimate the total energy resolution and to check the condition of the analyzer. The total energy resolution ({delta}E/E) is up to 0.78%, which is much higher than the old type. The PIAD of HOPG we obtained was the ring pattern as expected. Therefore, a detailed three-dimensional Fermi surface mapping and an analysis of the atomic orbitals constituting the electron energy bands are possible by combiningmore » them with a linearly polarized synchrotron radiation.« less

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Diana Dragomir, NASA Hubble Postdoctoral Fellow, Massachusetts Institute of Technology, answered questions during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

Permanent Habitats in Earth-Sol/Mars-Sol Orbit Positions

NASA Astrophysics Data System (ADS)

Greenspon, J.

Project Outpost is a manned Earth-Sol/Mars-Sol platform that enables permanent occupation in deep space. In order to develop the program elements for this complex mission, Project Outpost will rely primarily on existing/nearterm technology and hardware for the construction of its components. For the purposes of this study, four mission requirements are considered: 1. Outpost - Man's 1st purpose-produced effort of space engineering, in which astructure is developed/constructed in an environment completely alien to currentpractices for EVA guidelines. 2. Newton - a concept study developed at StarGate Research, for the development ofa modified Hohmann personnel orbital transport operating between Earth andMars. Newton would serve as the primary crew delivery apparatus throughrepeatable transfer scheduling for all Earth-Lpoint-Mars activities. Thispermanent "transit system" would establish the foundations for Solar systemcolonization. 3. Cruis - a concept study developed at StarGate Research, for the development of amodified Hohmann cargo orbital transport operating between Earth and Mars.Cruis would serve as the primary equipment delivery apparatus throughrepeatable transfer scheduling for all Earth-Lpoint-Mars activities. Thispermanent "transit system" would establish the foundations for Solar systemcolonization, and 4. Ares/Diana - a more conventional space platform configuration for Lunar andMars orbit is included as a construction baseline. The operations of these assetsare supported, and used for the support, of the outpost. Outpost would be constructed over a 27-year period of launch opportunities into Earth-Sol or Mars-Sol Lagrange orbit (E-S/M-S L1, 4 or 5). The outpost consists of an operations core with a self-contained power generation ability, a docking and maintenance structure, a Scientific Research complex and a Habitation Section. After achieving initial activation, the core will provide the support and energy required to operate the outpost in a 365 day orbit - with a resupply schedule of 120 days. The initial power grid, based on the ISS's solar array, provides energy during the initial start-up phases. The Operations Core serves as the backbone of the outpost, providing a centrally defined structural brace for other elements. After placement, the core is energized through the deployment of 2 ISS solar wings. Gravitation via rotation will occur approximately 450 days later, with the completion of the habitat elements, when the main reaction control engines are fired to provide an artificial gravity of 8.77 m/s. Station operations begin with deployment of the solar arrays and charging of the battery systems. Newton and Cruis assist in the transporting of supplies and personnel from Earth to Mars via the Outpost, and serve as a crucial component to a long term space exploration/colonization initiative. The cycling spacecraft means of travel has advantages in that it is readily repeatable, immediately demonstrating a long term commitment. The cycling spacecraft, however, represent a less than mature technology. The transportation system between Earth - Outpost - Mars will be perpetually on a duplicate development track with it's "stops". Ares/Diana is advantageous in that they are completely conventional mission profiles with modules and knowledge imported from the International Space Station. While Diana represents a logical next step from Earth, Ares will undoubtedly be developed alongside the Outpost itself.

Potential soil organic carbon stocks in semi arid areas under climate change scenarios: an application of CarboSOIL model in northern Egypt

NASA Astrophysics Data System (ADS)

Muñoz-Rojas, Miriam; Abd-Elmabod, Sameh K.; Jordán, Antonio; Zavala, Lorena M.; Anaya-Romero, Maria; De la Rosa, Diego

2014-05-01

1. INTRODUCTION Climate change is predicted to have a large impact on semi arid areas which are often degraded and vulnerable to environmental changes (Muñoz-Rojas et al., 2012a; 2012b; 2013). However, these areas might play a key role in mitigation of climate change effects through sequestration of carbon in soils (United Nations, 2011). At the same time, increasing organic carbon in these environments could be beneficial for soil erosion control, soil fertility and, ultimately, food production (Lal, 2004). Several approaches have been carried out to evaluate climate change impacts on soil organic carbon (SOC) stocks, but soil carbon models are amongst the most effective tools to assess C stocks, dynamics and distribution and to predict trends under climate change scenarios (Jones et al., 2005 ). CarboSOIL is an empirical model based on regression techniques and developed to predict SOC contents at standard soil depths of 0 to 25, 25 to 50 and 50-75 cm (Muñoz-Rojas et al., 2013). CarboSOIL model has been designed as a GIS-integrated tool and is a new component of the agroecological decision support system for land evaluation MicroLEIS DSS (De la Rosa et al., 2004). 2. GENERAL METHODS In this research, CarboSOIL was applied in El-Fayoum depression, a semi arid region located in northern Egypt with a large potential for agriculture (Abd-Elmabod et al, 2012). The model was applied in a total of six soil-units classified according the USDA Soil Taxonomy system within the orders Entisols and Aridisols under different climate climate change scenarios. Global climate models based on the Organisation for Economic Co-operation and Development (Agrawala at al., 2004) and the Intergovernmental Panel on Climate Change (IPCC, 2007) were applied to predict short-, medium- and long-term trends (2030, 2050 and 2100) of SOC dynamics and sequestration at different soil depths (0-25, 25-50 and 50-75) and land use types (irrigated areas, olive groves, wheat, cotton and other annual crops, and fruit trees and berries). 3. RESULTS AND CONCLUSIONS According to results, considerable decreases of SOC stocks are expected in the 25-50 cm soil section under all considered land use types and all projected scenarios, in particular in Vertic Torrifluvents and Typic Torrifluvents under wheat, cotton and other annual crops. Oppositely, SOC stocks tend to increase in the deeper soil section (50-75 cm), mostly in Typic Haplocalcids under permanently irrigated areas and olive groves in the 2100 scenario. In the upper layer (0-25 cm), slight increases have been predicted under all considered land use types. The methodology used in this research could be applied to other semi arid areas with available soil, land use and climate data. Moreover, the information developed in this study might support decision-making for land use planning, agricultural management and climate adaptation strategies in semi arid regions. REFERENCES Abd-Elmabod, S.K., Ali, R.R., Anaya-Romero, M., Jordán, A., Muñoz-Rojas, M., Abdelmageed, T.A., Zavala, L.M., De la Rosa, D. 2012. Evaluating soil degradation under different scenarios of agricultural land management in Mediterranean region. Nature and Science 10, 103-116. Agrawala, S., A. Moehner, M. El Raey, D. Conway, M. van Aalst, M. Hagenstad and J. Smith. 2004. Development and Climate Change In Egypt: Focus on Coastal Resources and the Nile. Organisation for Economic Co-operation and Development. De la Rosa, D., Mayol, F., Moreno, F., Cabrera, F., Díaz-Pereira, E., Antoine, J. 2002. A multilingual soil profile database (SDBm Plus) as an essential part of land resources information systems. Environmental Modelling & Software 17, 721-730. DOI: 10.1016/S1364-8152(02)00031-2. IPCC. 2007. Climate Change 2007: The Physical Science Basis. Cambridge/New York: Cambridge University Press Jones, C., McConnell, C., Coleman, K., Cox, P., Falloon, P., Jenkinson, D. and Powlson, D. 2005. Global climate change and soil carbon stocks; predictions from two contrasting models for the turnover of organic carbon in soil. Global Change Biology 11: 154-166 Lal, R. 2004. Soil carbon sequestration to mitigate climate change. Geoderma 123, 1-22. DOI: 10.1016/j.geoderma.2004.01.032. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., De la Rosa, D., Abd-Elmabod, S.K., Anaya-Romero, M. 2012a. Impact of land use and land cover changes on organic carbon stocks in Mediterranean soils (1956-2007). Land Degradation & Development. In press. DOI: 10.1002/ldr.2194. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., De la Rosa, D., Abd-Elmabod, S.K., Anaya-Romero, M. 2012b. Organic carbon stocks in Mediterranean soil types under different land uses (Southern Spain). Solid Earth 3, 375-386. DOI: 10.5194/se-3-375-2012. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., González-Peñaloza, F.A., De la Rosa, D., Anaya-Romero, M. 2013. Modelling soil organic carbon stocks in global change scenarios: a CarboSOIL application. Biogeosciences Discussions 10, 10997-11035. DOI: 10.5194/bgd-10-10997-2013. United Nations. 2011. Global Drylands: A UN system-wide response. Full Report. United Nations Environment Management Group.

Mobile Phone Interventions for Sleep Disorders and Sleep Quality: Systematic Review.

PubMed

Shin, Jong Cheol; Kim, Julia; Grigsby-Toussaint, Diana

2017-09-07

Although mobile health technologies have been developed for interventions to improve sleep disorders and sleep quality, evidence of their effectiveness remains limited. A systematic literature review was performed to determine the effectiveness of mobile technology interventions for improving sleep disorders and sleep quality. Four electronic databases (EBSCOhost, PubMed/Medline, Scopus, and Web of Science) were searched for articles on mobile technology and sleep interventions published between January 1983 and December 2016. Studies were eligible for inclusion if they met the following criteria: (1) written in English, (2) adequate details on study design, (3) focus on sleep intervention research, (4) sleep index measurement outcome provided, and (5) publication in peer-reviewed journals. An initial sample of 2679 English-language papers were retrieved from five electronic databases. After screening and review, 16 eligible studies were evaluated to examine the impact of mobile phone interventions on sleep disorders and sleep quality. These included one case study, three pre-post studies, and 12 randomized controlled trials. The studies were categorized as (1) conventional mobile phone support and (2) utilizing mobile phone apps. Based on the results of sleep outcome measurements, 88% (14/16) studies showed that mobile phone interventions have the capability to attenuate sleep disorders and to enhance sleep quality, regardless of intervention type. In addition, mobile phone intervention methods (either alternatively or as an auxiliary) provide better sleep solutions in comparison with other recognized treatments (eg, cognitive behavioral therapy for insomnia). We found evidence to support the use of mobile phone interventions to address sleep disorders and to improve sleep quality. Our findings suggest that mobile phone technologies can be effective for future sleep intervention research. ©Jong Cheol Shin, Julia Kim, Diana Grigsby-Toussaint. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 07.09.2017.

Effect of Temperature and Time on Fecal Hemoglobin Stability in 5 Fecal Immunochemical Test Methods and One Guaiac Method.

PubMed

Catomeris, Peter; Baxter, Nancy N; Boss, Sheila C; Paszat, Lawrence F; Rabeneck, Linda; Randell, Edward; Serenity, Mardie L; Sutradhar, Rinku; Tinmouth, Jill

2018-01-01

- Although promising for colorectal cancer screening, hemoglobin (Hb) stability remains a concern with fecal immunochemical tests. This study implemented a novel, standardized method to compare Hb stability across various fecal immunochemical tests. The method can be used to inform decisions when selecting a kit for use in colorectal cancer screening. In so doing, this work addressed a critical need for standardization in this field. - To compare the stability of Hb across 5 different immunochemical kits and one guaiac kit. - The stability of Hb was analyzed in collection devices inoculated with Hb-spiked feces and (1) stored at various temperatures (frozen, refrigerated, ambient, and elevated) for more than 60 days; (2) after undergoing 3 controlled, freeze-thaw cycles; and (3) after being transported by courier or postal services in uncontrolled temperature conditions from 3 locations in Ontario, Canada, to a central testing center. - The stability of Hb varied with time and temperature and by kit. Lower Hb recoveries occurred with increasing temperature and increasing time from sample collection to testing. Refrigeration provided the best stability, although results varied across kits (eg, from 4.2 days to >60 days before a prespecified threshold [<70% probability of the test results remaining positive] was reached). Freeze-thaw stability varied across kits and cycles (Hb recoveries: NS Plus [Alfresa Pharma, Chuo-ku, Osaka, Japan], 91.7% to 95.4%; OC Diana [Eiken Chemical, Taito-ku, Tokyo, Japan], 57.6% to 74.9%). Agreement regarding Hb levels before and after transportation varied across kits (from 57% to 100%). - Important differences in Hb stability were found across the included fecal immunochemical tests. These findings should inform practice-based and population-based colorectal cancer screening.

VizieR Online Data Catalog: Molecular clouds with GLIMPSE/MIPSGAL data (Retes-Romero+, 2017)

NASA Astrophysics Data System (ADS)

Retes-Romero, R.; Mayya, Y. D.; Luna, A.; Carrasco, L.

2017-11-01

All of the 12 selected molecular clouds have GLIMPSE and MIPSGAL public data available. Typical Spitzer RGB images (3.6um, 8.0um, and 24um) of the resulting sample of clouds are shown in Figure 1, where the position of the IRAS source is identified. In order to define the parent molecular cloud that harbors the high-mass star-forming regions, we used 13CO(J=1-0) emission data from the Galactic Ring Survey (GRS) database (Jackson+ 2006ApJS..163..145J). The survey data have a velocity resolution of 0.21km/s, a typical (1σ) rms sensitivity of ~0.13K, a main beam efficiency of {eta}mb=0.48, and a beam of 46". The 13CO emission spectra for the line of sight (LOS) to the selected IRAS sources are shown in Figure 2, where the observed velocity of the CS(J=2-1) emission line (Bronfman+ 1996, J/A+AS/115/81) is also marked. (3 data files).

Glaciers in Patagonia: Controversy and prospects

NASA Astrophysics Data System (ADS)

Kargel, J. S.; Alho, P.; Buytaert, W.; Célleri, R.; Cogley, J. G.; Dussaillant, A.; Guido, Z.; Haeberli, W.; Harrison, S.; Leonard, G.; Maxwell, A.; Meier, C.; Poveda, G.; Reid, B.; Reynolds, J.; Rodríguez, C. A. Portocarrero; Romero, H.; Schneider, J.

2012-05-01

Lately, glaciers have been subjects of unceasing controversy. Current debate about planned hydroelectric facilities—a US7- to 10-billion megaproject—in a pristine glacierized area of Patagonia, Chile [Romero Toledo et al., 2009; Vince, 2010], has raised anew the matter of how glaciologists and global change experts can contribute their knowledge to civic debates on important issues. There has been greater respect for science in this controversy than in some previous debates over projects that pertain to glaciers, although valid economic motivations again could trump science and drive a solution to the energy supply problem before the associated safety and environmental problems are understood. The connection between glaciers and climate change—both anthropogenic and natural—is fundamental to glaciology and to glaciers' practical importance for water and hydropower resources, agriculture, tourism, mining, natural hazards, ecosystem conservation, and sea level [Buytaert et al., 2010; Glasser et al., 2011]. The conflict between conservation and development can be sharper in glacierized regions than almost anywhere else. Glaciers occur in spectacular natural landscapes, but they also supply prodigious exploitable meltwater.

Bring an axe and your wildest dreams: Post-apocalyptic desires, science distrust, and the de(con)struction of a zombie story

NASA Astrophysics Data System (ADS)

Long, Samantha Jo

Observing the current popularity of the zombie narrative in American culture, this thesis explores the questions "why zombie?" and "why now?" through a combination of research and the creation of an original zombie story. Moving beyond existing criticism which argues that the zombie transforms to fit each generation's specific fears, I argue that zombie movies, novels, and video games from George A. Romero-onwards continually speak to a distrust of science and scientific progress while additionally romanticizing the post-apocalyptic landscape. Consequently, the zombie's unprecedented mainstream popularity over the last fifteen years could be read as symptomatic of this distrust intensifying, paralleling an increasing politicization of science and a rise in apocalyptic thinking within the public sphere. Through the deconstruction of my own zombie story, I uncover not only what these timely narratives tell us about our perceptions of the future, but also how they can help us change them.

Differences in Muscle Activation and Kinematics Between Cable-Based and Selectorized Weight Training.

PubMed

Signorile, Joseph F; Rendos, Nicole K; Heredia Vargas, Hector H; Alipio, Taislaine C; Regis, Rebecca C; Eltoukhy, Moataz M; Nargund, Renu S; Romero, Matthew A

2017-02-01

Signorile, JF, Rendos, NK, Heredia Vargas, HH, Alipio, TC, Regis, RC, Eltoukhy, MM, Nargund, RS, and Romero, MA. Differences in muscle activation and kinematics between cable-based and selectorized weight training. J Strength Cond Res 31(2): 313-322, 2017-Cable resistance training machines are showing resurgent popularity and allow greater number of degrees of freedom than typical selectorized equipment. Given that specific kinetic chains are used during distinct activities of daily living (ADL), cable machines may provide more effective interventions for some ADL, whereas others may be best addressed using selectorized equipment. This study examined differences in activity levels (root mean square of the EMG [rmsEMG]) of 6 major muscles (pectoralis major, PM; anterior deltoid, AD; biceps brachii, BB; rectus abdominis, RA; external obliques, EO; and triceps brachii, TB) and kinematics of multiple joints between a cable and standard selectorized machines during the biceps curl, the chest press, and the overhead press performed at 1.5 seconds per contractile stage. Fifteen individuals (9 men, 6 women; mean age ± SD, 24.33 ± 4.88 years) participated. Machine order was randomized. Significant differences favoring cable training were seen for PM and AD during biceps curl; BB, AD, and EO for chest press; and BB and EO during overhead press (p ≤ 0.05). Greater starting and ending angles were seen for the elbow and shoulder joints during selectorized biceps curl, whereas hip and knee starting and ending angles were greater for cable machine during chest and overhead presses (p < 0.0001). Greater range of motion (ROM) favoring the cable machine was also evident (p < 0.0001). These results indicate that utilization patterns of selected muscles, joint angles, and ROMs can be varied because of machine application even when similar exercises are used, and therefore, these machines can be used selectively in training programs requiring specific motor or biomechanical patterns.

Bridging the Particle Physics and Big Data Worlds

NASA Astrophysics Data System (ADS)

Pivarski, James

2017-09-01

For decades, particle physicists have developed custom software because the scale and complexity of our problems were unique. In recent years, however, the ``big data'' industry has begun to tackle similar problems, and has developed some novel solutions. Incorporating scientific Python libraries, Spark, TensorFlow, and machine learning tools into the physics software stack can improve abstraction, reliability, and in some cases performance. Perhaps more importantly, it can free physicists to concentrate on domain-specific problems. Building bridges isn't always easy, however. Physics software and open-source software from industry differ in many incidental ways and a few fundamental ways. I will show work from the DIANA-HEP project to streamline data flow from ROOT to Numpy and Spark, to incorporate ideas of functional programming into histogram aggregation, and to develop real-time, query-style manipulations of particle data.

Linear Combination Fitting (LCF)-XANES analysis of As speciation in selected mine-impacted materials

EPA Pesticide Factsheets

This table provides sample identification labels and classification of sample type (tailings, calcinated, grey slime). For each sample, total arsenic and iron concentrations determined by acid digestion and ICP analysis are provided along with arsenic in-vitro bioaccessibility (As IVBA) values to estimate arsenic risk. Lastly, the table provides linear combination fitting results from synchrotron XANES analysis showing the distribution of arsenic speciation phases present in each sample along with fitting error (R-factor).This dataset is associated with the following publication:Ollson, C., E. Smith, K. Scheckel, A. Betts, and A. Juhasz. Assessment of arsenic speciation and bioaccessibility in mine-impacted materials. Diana Aga, Wonyong Choi, Andrew Daugulis, Gianluca Li Puma, Gerasimos Lyberatos, and Joo Hwa Tay JOURNAL OF HAZARDOUS MATERIALS. Elsevier Science Ltd, New York, NY, USA, 313: 130-137, (2016).

KSC-02pd0616

NASA Image and Video Library

2002-04-29

KENNEDY SPACE CENTER, FLA. -- The Honorable Diana Morgan speaks to attendees at the opening ceremony kicking off a new program known as SABRE, Space Agricultural Biotechnology Research and Education. In the foreground are Center Director Roy D. Bridges Jr. (left) and U.S. Representative Dave Weldon (right). The SABRE program is a combined effort of the University of Florida and NASA. Morgan is vice chair on the UF Board of Trustees. SABRE will focus on the discovery, development and application of the biological aspects of advanced life support strategies. The program will include faculty from UF's Institute of Food and Agricultural Sciences, who will be located at both KSC - in the state-owned Space Experiment Research and Processing Laboratory (SERPL) being built there - and UF in Gainesville. SABRE will be directed by Robert Ferl, professor in the horticultural sciences department and assistant director of UF's Biotechnology Program. He will be responsible for coordinating the research and education efforts of UF and NASA

Physician involvement enhances coding accuracy to ensure national standards: an initiative to improve awareness among new junior trainees.

PubMed

Nallasivan, S; Gillott, T; Kamath, S; Blow, L; Goddard, V

2011-06-01

Record Keeping Standards is a development led by the Royal College of Physicians of London (RCP) Health Informatics Unit and funded by the National Health Service (NHS) Connecting for Health. A supplementary report produced by the RCP makes a number of recommendations based on a study held at an acute hospital trust. We audited the medical notes and coding to assess the accuracy, documentation by the junior doctors and also to correlate our findings with the RCP audit. Northern Lincolnshire & Goole Hospitals NHS Foundation Trust has 114,000 'finished consultant episodes' per year. A total of 100 consecutive medical (50) and rheumatology (50) discharges from Diana Princess of Wales Hospital from August-October 2009 were reviewed. The results showed an improvement in coding accuracy (10% errors), comparable to the RCP audit but with 5% documentation errors. Physician involvement needs enhancing to improve the effectiveness and to ensure clinical safety.

Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose.

PubMed Central

Yagi, Toshihiro; Baroja-Fernández, Edurne; Yamamoto, Ryuji; Muñoz, Francisco José; Akazawa, Takashi; Hong, Kyoung Su; Pozueta-Romero, Javier

2003-01-01

A distinct UDP-glucose (UDPG) pyrophosphatase (UGPPase, EC 3.6.1.45) has been characterized using pig kidney ( Sus scrofa ). This enzyme hydrolyses UDPG, the precursor molecule of numerous glycosylation reactions in animals, to produce glucose 1-phosphate (G1P) and UMP. Sequence analyses of the purified enzyme revealed that, similar to the case of a nucleotide-sugar hydrolase controlling the intracellular levels of ADP-glucose linked to glycogen biosynthesis in Escherichia coli [Moreno-Bruna, Baroja-Fernández, Muñoz, Bastarrica-Berasategui, Zandueta-Criado, Rodri;guez-López, Lasa, Akazawa and Pozueta-Romero (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8128-8132], UGPPase appears to be a member of the ubiquitously distributed group of nucleotide pyrophosphatases designated Nudix hydrolases. A complete cDNA of the UGPPase-encoding gene, designated UGPP, was isolated from a human thyroid cDNA library and expressed in E. coli. The resulting cells accumulated a protein that showed kinetic properties identical to those of pig UGPPase. PMID:12429023

Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose.

PubMed

Yagi, Toshihiro; Baroja-Fernández, Edurne; Yamamoto, Ryuji; Muñoz, Francisco José; Akazawa, Takashi; Hong, Kyoung Su; Pozueta-Romero, Javier

2003-03-01

A distinct UDP-glucose (UDPG) pyrophosphatase (UGPPase, EC 3.6.1.45) has been characterized using pig kidney ( Sus scrofa ). This enzyme hydrolyses UDPG, the precursor molecule of numerous glycosylation reactions in animals, to produce glucose 1-phosphate (G1P) and UMP. Sequence analyses of the purified enzyme revealed that, similar to the case of a nucleotide-sugar hydrolase controlling the intracellular levels of ADP-glucose linked to glycogen biosynthesis in Escherichia coli [Moreno-Bruna, Baroja-Fernández, Muñoz, Bastarrica-Berasategui, Zandueta-Criado, Rodri;guez-López, Lasa, Akazawa and Pozueta-Romero (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8128-8132], UGPPase appears to be a member of the ubiquitously distributed group of nucleotide pyrophosphatases designated Nudix hydrolases. A complete cDNA of the UGPPase-encoding gene, designated UGPP, was isolated from a human thyroid cDNA library and expressed in E. coli. The resulting cells accumulated a protein that showed kinetic properties identical to those of pig UGPPase.

Use of multiple cluster analysis methods to explore the validity of a community outcomes concept map.

PubMed

Orsi, Rebecca

2017-02-01

Concept mapping is now a commonly-used technique for articulating and evaluating programmatic outcomes. However, research regarding validity of knowledge and outcomes produced with concept mapping is sparse. The current study describes quantitative validity analyses using a concept mapping dataset. We sought to increase the validity of concept mapping evaluation results by running multiple cluster analysis methods and then using several metrics to choose from among solutions. We present four different clustering methods based on analyses using the R statistical software package: partitioning around medoids (PAM), fuzzy analysis (FANNY), agglomerative nesting (AGNES) and divisive analysis (DIANA). We then used the Dunn and Davies-Bouldin indices to assist in choosing a valid cluster solution for a concept mapping outcomes evaluation. We conclude that the validity of the outcomes map is high, based on the analyses described. Finally, we discuss areas for further concept mapping methods research. Copyright © 2016 Elsevier Ltd. All rights reserved.

Numerical modelling techniques of soft soil improvement via stone columns: A brief review

NASA Astrophysics Data System (ADS)

Zukri, Azhani; Nazir, Ramli

2018-04-01

There are a number of numerical studies on stone column systems in the literature. Most of the studies found were involved with two-dimensional analysis of the stone column behaviour, while only a few studies used three-dimensional analysis. The most popular software utilised in those studies was Plaxis 2D and 3D. Other types of software that used for numerical analysis are DIANA, EXAMINE, ZSoil, ABAQUS, ANSYS, NISA, GEOSTUDIO, CRISP, TOCHNOG, CESAR, GEOFEM (2D & 3D), FLAC, and FLAC 3. This paper will review the methodological approaches to model stone column numerically, both in two-dimensional and three-dimensional analyses. The numerical techniques and suitable constitutive model used in the studies will also be discussed. In addition, the validation methods conducted were to verify the numerical analysis conducted will be presented. This review paper also serves as a guide for junior engineers through the applicable procedures and considerations when constructing and running a two or three-dimensional numerical analysis while also citing numerous relevant references.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. From left are moderator Claire Saravia, NASA Communications; Paul Hertz, Astrophysics Division director, NASA Headquarters; George Ricker, TESS principal investigator, Massachusetts Institute of Technology; Padi Boyd, TESS Guest Investigator Program lead, NASA’s Goddard Space Flight Center; Stephen Rinehart, TESS Project scientist, NASA’s Goddard Space Flight Center; and Diana Dragomir, NASA Hubble Postdoctoral Fellow, Massachusetts Institute of Technology. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

The heirs of Aradia, daughters of Diana: community in the second and third wave.

PubMed

Dickie, Jane R; Cook, Anna; Gazda, Rachel; Martin, Bethany; Sturrus, Elizabeth

2005-01-01

What happens when young third wave feminists learn from second wave feminists what living in community means? This article gives an account of engagement between generations of second and third wave feminists as the younger women began documenting the herstory of Aradia, a radical, separatist and mostly lesbian community and non-profit organization in conservative West Michigan in the 1970s and 1980s. The younger women learned the importance of non-hierarchical political organizing to counter differences of experience and power. They learned that divisions of work and play prevent the development of community and that "high play" is critically important for creative energy and insight. And they learned that mythmaking is more than fantasy; it creates reality. The older women learned that for the third wave identity and sexuality are more fluid. They learned that the younger feminists recognized and valued their contributions, and sought to carry feminist goals forward. Both generations were empowered by the encounter and learned the radical effects of women speaking across generations.

Major deepwater pipelay vessel starts work in North Sea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heerema, E.P.

1998-05-04

Industry`s deepwater pipelaying capability has received a boost this year with the entry into the world`s fleet of Solitaire, a dynamically positioned pipelay vessel of about 350 m including stinger. The converted bulk carrier, formerly the Trentwood, will arrive on station in the North Sea and begin laying pipe this month on Statoil`s Europipe II project, a 600-km, 42-in. OD gas pipeline from Norway to Germany. Next year, the vessel will install pipe for the Exxon U.S.A.`s Gulf of Mexico South Diana development (East Breaks Block 945) in a water depth of 1,643 m and for Mobil Oil Canada asmore » part of the Sable Island Offshore and Energy Project offshore Nova Scotia. Using the S-lay mode, Solitaire is particularly well-suited for laying large lines economically, including the deepwater projects anticipated for the US Gulf of Mexico. Table 1 presents Solitaire`s technical specifications. The design, construction, pipelaying, and justification for building vessels such as the Solitaire are discussed.« less

[Prenatal patient cards and quality of prenatal care in public health services in Greater Metropolitan Vitória, Espírito Santo State, Brazil].

PubMed

Santos Neto, Edson Theodoro dos; Oliveira, Adauto Emmerich; Zandonade, Eliana; Gama, Silvana Granado Nogueira da; Leal, Maria do Carmo

2012-09-01

This study aimed to assess the completeness of prenatal care information on the patients' prenatal care cards, according to coverage by various public health services: Family Health Strategy (FHS), Community-Based Health Workers' Program (CBHWP), and traditional Primary Care Units (PCU) in Greater Metropolitan Vitória, Espírito Santo State, Brazil. In a cross-sectional study, 1,006 prenatal cards were randomly selected from postpartum women at maternity hospitals in the metropolitan area. Completeness of the cards was assessed according to the criteria proposed by Romero & Cunha, which measure the quality on a scale from excellent (< 5% incomplete cards) to very bad (> 50% incomplete cards). In general, completion of information on the cards was bad (> 20% incomplete), but cards were filled out better in the FHS than in the CBHWP and PCU, especially for tetanus vaccination (p = 0.016) and gestational weight (p = 0.039). In conclusion, the quality of prenatal care in the public health system in Greater Metropolitan Vitória fails to meet the Brazilian national guidelines for maternal and child health.

Introduction to the Special Section: Linking the MMPI-2-RF to Contemporary Models of Psychopathology.

PubMed

Sellbom, Martin; Arbisi, Paul A

2017-01-01

This special section considers 9 independent articles that seek to link the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008/ 2011 ) to contemporary models of psychopathology. Sellbom ( this issue ) maps the Specific Problems scales onto hierarchical psychopathology structures, whereas Romero, Toorabally, Burchett, Tarescavage, and Glassmire ( this issue ) and Shkalim, Almagor, and Ben-Porath ( this issue ) show evidence of linking the instruments' scales to diagnostic representations of common higher order psychopathology constructs. McCord, Achee, Cannon, Harrop, and Poynter ( this issue ) link the MMPI-2-RF scales to psychophysiological constructs inspired by the National Institute of Mental Health (NIMH) Research Domain Criteria. Sellbom and Smith ( this issue ) find support for MMPI-2-RF scale hypotheses in covering personality psychopathology in general, whereas Klein Haneveld, Kamphuis, Smid, and Forbey ( this issue ) and Kutchen et al. ( this issue ) demonstrate the utility of the MMPI-2-RF in capturing contemporary conceptualizations of the psychopathic personality. Finally, Franz, Harrop, and McCord ( this issue ) and Rogers et al. ( this issue ) mapped the MMPI-2-RF scales onto more specific transdiagnostic constructs reflecting interpersonal functioning and suicide behavior proneness, respectively.

Theory of flux cutting and flux transport at the critical current of a type-II superconducting cylindrical wire

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clem, John R

2011-02-17

I introduce a critical-state theory incorporating both flux cutting and flux transport to calculate the magnetic-field and current-density distributions inside a type-II superconducting cylinder at its critical current in a longitudinal applied magnetic field. The theory is an extension of the elliptic critical-state model introduced by Romero-Salazar and Pérez-Rodríguez. The vortex dynamics depend in detail on two nonlinear effective resistivities for flux cutting (ρ{sub ∥}) and flux flow (ρ{sub ⊥}), and their ratio r=ρ{sub ∥}/ρ{sub ⊥}. When r<1, the low relative efficiency of flux cutting in reducing the magnitude of the internal magnetic-flux density leads to a paramagnetic longitudinal magneticmore » moment. As a model for understanding the experimentally observed interrelationship between the critical currents for flux cutting and depinning, I calculate the forces on a helical vortex arc stretched between two pinning centers when the vortex is subjected to a current density of arbitrary angle Φ. Simultaneous initiation of flux cutting and flux transport occurs at the critical current density J{sub c}(Φ) that makes the vortex arc unstable.« less

Theory of flux cutting and flux transport at the critical current of a type-II superconducting cylindrical wire

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clem, John R.

2011-02-17

I introduce a critical-state theory incorporating both flux cutting and flux transport to calculate the magnetic-field and current-density distributions inside a type-II superconducting cylinder at its critical current in a longitudinal applied magnetic field. The theory is an extension of the elliptic critical-state model introduced by Romero-Salazar and Perez-Rodriguez. The vortex dynamics depend in detail on two nonlinear effective resistivities for flux cutting ({rho}{parallel}) and flux flow ({rho}{perpendicular}), and their ratio r = {rho}{parallel}/{rho}{perpendicular}. When r < 1, the low relative efficiency of flux cutting in reducing the magnitude of the internal magnetic-flux density leads to a paramagnetic longitudinal magneticmore » moment. As a model for understanding the experimentally observed interrelationship between the critical currents for flux cutting and depinning, I calculate the forces on a helical vortex arc stretched between two pinning centers when the vortex is subjected to a current density of arbitrary angle {phi}. Simultaneous initiation of flux cutting and flux transport occurs at the critical current density J{sub c}({phi}) that makes the vortex arc unstable.« less

Theory of flux cutting and flux transport at the critical current of a type-II superconducting cylindrical wire

NASA Astrophysics Data System (ADS)

Clem, John R.

2011-06-01

I introduce a critical-state theory incorporating both flux cutting and flux transport to calculate the magnetic-field and current-density distributions inside a type-II superconducting cylinder at its critical current in a longitudinal applied magnetic field. The theory is an extension of the elliptic critical-state model introduced by Romero-Salazar and Pérez-Rodríguez. The vortex dynamics depend in detail on two nonlinear effective resistivities for flux cutting (ρ∥) and flux flow (ρ⊥), and their ratio r=ρ∥/ρ⊥. When r<1, the low relative efficiency of flux cutting in reducing the magnitude of the internal magnetic-flux density leads to a paramagnetic longitudinal magnetic moment. As a model for understanding the experimentally observed interrelationship between the critical currents for flux cutting and depinning, I calculate the forces on a helical vortex arc stretched between two pinning centers when the vortex is subjected to a current density of arbitrary angle ϕ. Simultaneous initiation of flux cutting and flux transport occurs at the critical current density Jc(ϕ) that makes the vortex arc unstable.

Shrublands and Soil Erosion. An State-of-the-Art

NASA Astrophysics Data System (ADS)

García Estríngana, Pablo; Dunkerley, David; Cerdà, Artemi

2014-05-01

Shrublands and Soil Erosion. An State-of-the-Art Arid and semiarid regions occupy two-fifth of the continents (Reynolds et al., 2007). These regions are characterized by dry climatic conditions, recurrent droughts and a scant rainfall pattern with a marked seasonality and a high inter-annual variability which makes water to be a scant resource and vegetation to follow a high variability spatial distribution pattern (Breshears et al., 1998; Cecchi et al., 2006; Dunkerley, 2008). These conditions make these areas more sensitive to climate change (Rowell, 2005) and to land use change as a consequence of land abandonment (Poyatos et al., 2003; Delgado et al., 2010; García-Ruiz, 2010), increasing the risk of desertification (Puigdefábregas and Mendizabal, 1998; Geeson et al., 2002), in such a way that 65-70% of arid and semiarid areas are vulnerable to this degradation process (UNEP, 1991). Soil Erosion and Land Degradation are closely related to the changes in the vegetation cover (Zhao et al., 2013). Although other factors such as rainfall intensity or slope (Ziadat and Taimeh, 2013) the plant cover is the main factor that controls the soil erosion, controlling the infiltration and runoff generation (Cerdà, 1998a; Kargar Chigani et al., 2012; Haregeweyn, 2013). Soil erosion show non-sustainable rates under these regions, such as under Mediterranean conditions (Cerdà et al., 2010) and on agriculture land (Cerdà et al; 2007; 2009) due to climatic conditions, to parent material and to the roughed terrain (Romero Díaz et al., 2010). The traditional impact of grazing, of extremely intense fires, of ploughing and the widespread use of herbicides on agriculture, the increase of the road and railway embankments and the agricultural land abandonment cause vegetation removal. Canopy cover partitions rainfall reducing the amount of water reaching the soil and the kinetic energy of rainfall drops, protecting the soil against the impact of rainfall drops. Vegetation distribution controls the exposure of soils to rainfall drops affecting soil erosion (Cerdà, 1997a; Cammeraat et al., 2010; Kakembo et al., 2012). The lost of vegetation can trigger Desertification (Izzo et al., 2013) because soil erosion is highly dependent on the effective rainfall striking soil particles (Cerdà and Lasanta, 2005; Haile and Fetene; 2012; Miao et al., 2012, Prokop and Poręba, 2012). Shrubs are the most characteristic vegetation type in semiarid and arid ecosystems all over the world (Tomaselli, 1981; Kummerrow, 1989), typical of intermediate stages of most vegetation succession series, being the first in terms of dominant vegetation coverage, occupying 24% of drylands, followed by crop vegetation with 20% (Reynolds et al., 2007). Moreover, shrub vegetation covers the soil permanently, being able to adapt to very unfavourable conditions like droughts, frosts, non-fertile soils,… improving the soil quality due to their capacity to activate organic matter cycles supplying greater amounts of litter (Alegre et al., 2004). Shrubs have complex root systems, inducing changes in soil properties and increasing soil macroporosity (indirect effects) that increase infiltration reducing runoff and the soil loss (Garcia-Estringana et al., 2010). Shrubs improve the infiltration capacity of soils (Cerdà, 1997), even in the most difficult conditions (Marques et al., 2005), the water retention capacity (Ruiz Sinoga et al., 2010) and the runoff and sediment redistribution. Shrub vegetation has been seen as a key vegetation cover in semiarid lands to control the soil and water losses (Francis and Thornes, 1990; Barea et al., 1996; Romero Díaz, 2003; Cerdà and Doerr, 2007). But the majority of revegetation programmes in arid and semiarid regions still ignores the great potential of this type of vegetation. Romero Díaz et al. (2010) indicated that 99% of revegetation programmes carried out by public authorities in Spain used fast growing tree vegetation (Pinus sp. and Eucalyptus sp.) that grow faster in non-fertile soils resisting to isolation. But the introduction of these species is conducted using aggressive techniques like terracing, changing topography and making more vulnerable terrain to soil loss, with erosion rates one or two order of magnitude greater than other shrublands naturally recovered (Romero Díaz et al., 2010). In relation to tree vegetation shrubs cover the soil faster, being very efficient in reducing runoff and soil erosion (Kummerow, 1989; Haase et al., 2000), not being necessary aggressive techniques for revegetation operations. The land use is the key factor that determines the soil loss and the vegetation recovery which can contribute to reduce the soil and water losses. Land abandonment use to trigger an increase in soil erosion, but the vegetation recovery reduces the impact of the abandonment. The natural vegetation recovery is the most effective way to regenerate degraded soils although under arid and semiarid climatic conditions this process is delayed due to the water stress and soil degradation and revegetation programmes are carried out. A firm commitment for shrub vegetation is necessary for improving soil recovery in semiarid and arid lands. Acknowledgements The research projects 07 M/0077/1998, 07 M/0023/2000 and RTA01-078-C2- 2, GL2008-02879/BTE, LEDDRA243857 and RECARE FP7 project 603498 supported this research. References Alegre, J., Alonso-Blázquez, N., de Andrés, F., Tenorio, J.L., Ayerbe, L. 2004. Revegetation and reclamation of soils using wild leguminous shrubs in cold semiarid Mediterranean conditions: Litterfall and carbon and nitrogen returns under two aridity regimes. Plant and Soil 263, 203-112. Barea, J.M., Requena, N., Jimenez, I. 1996. A revegetation strategy based on the management of arbuscular mycorrhizae, Rhizobium and rhizobacteria for the reclamation of desertified Mediterranean shrubland ecosystems. In: Mycorrhization of Forest Plants under Arid and Semi-arid Conditions and Desertification Control in the Mediterranean, CIHEAM-IAMZ, Zaragoza, pp. 75-86. Breshears, D.D., Nyhan, J.W., Heil, C.E., Wilcox, B.P. 1998. Effects of woody plants on microclimate in a semiarid woodland: Soil temperature and evaporation in canopy and intercanopy patches. International Journal of Plant Sciences 159, 1010-1017. Cammeraat, E.L.H., Cerdà, A., Imeson, A.C. 2010. Ecohydrological adaptation of soils following land abandonment in a semi-arid environment. Ecohydrology 3, 421-430. Cecchi, G.A., Kröpfl, A.I., Villasuso, N.M., Distel, R.A. 2006. Stemflow and soil water redistribution in intact and disturbed plants of Larrea divaricata in southern Argentina. Arid Land Research and Management 20, 209-217. Cerdà, A. 1997. The effect of patchy distribution of Stipa tenacissima L. on runoff and erosion. Journal of Arid Environments 36, 37-51. Cerdà, A. 1998. Relationship between climate and soil hydrological and erosional characteristics along climatic gradients in Mediterranean limestone areas. Geomorphology, 25, 123-134. Cerdà, A., Imeson, A.C., Poesen, J., 2007. Soil Water Erosion in Rural Areas. Catena special issue 71, 191- 252. Cerdà, A., Flanagan, D.C., le Bissonnais, Y., Boardman, J., 2009. Soil Erosion and Agriculture. Soil and Tillage Research 106, 107-108. Cerdà, A., Hooke, J., Romero-Diaz, A., Montanarella, L., Lavee, H., 2010. Soil erosion on Mediterranean type-ecosystems. Land Degradation and Development 21, 71-74. Cerdà, A., Doerr, S.H. 2007. Soil wettability, runoff and erodibility of major dry-Mediterranean land use types on calcareous soils. Hydrological Processes, 21, 2325-2336. doi: 10.1016/j.catena.2008.03.010. Cerdà, A., Lasanta, A. 2005. Long-term erosional responses after fire in the Central Spanish Pyrenees: 1. Water and sediment yield. Catena, 60, 59-80. Delgado J, Llorens P, Nord G, Calder IR, Gallart F. 2010. Modelling the hydrological response of a Mediterranean medium-sized headwater basin subject to land cover change: the Cardener River basin (NE Spain). Journal of Hydrology 383: 125-134. DOI: 10.1016/j.jhydrol.2009.07.024 Dunkerley, D. 2008. Intra-storm evaporation as a component of canopy interception loss in dryland shrubs: observations from Fowlers Gap, Australia. Hydrological Processes 22, 1985-1995. Francis, C., Thornes, J.B. 1990. Matorral: Erosion and reclamation. En: Albaladejo, J., Stocking,, M.A., Díaz, E. (Eds.), Degradación y regeneración del suelo en condiciones ambientales mediterráneas. Consejo Superior de Investigaciones Científicas, Murcia, pp. 87-116. Garcia-Estringana, P., Alonso-Blázquez, N., Marques, M.J., Bienes, R., Alegre, J. 2010. Direct and indirect effects of Mediterranean vegetation on runoff and soil loss. European Journal of Soil Science 61, 174-185. García-Ruiz, J.M. 2010. The effects of land uses on soil erosion in Spain: a review. Catena 81, 1-11. Geeson, N., Brandt, C.J., Thornes, J.B. 2002. Mediterranean desertification: a mosaic of processes and responses. John Wiley & Sons, LTD, 433 pp. Haase, P., Pugnaire, F.I., Clark, S.C., Incoll, L.D. 2000. Photosynthetic rate and canopy development in the drought-deciduous shrub Anthyllis cytisoides L. Journal of Arid Environments 46, 79-91. Haile, G.W., Fetene, M. 2012. Assessment of soil erosion hazard in Kilie catchment, East Shoa, Ethiopia. Land Degradation and Development 23, 293-306. Haregeweyn, N., Poesen, J., Verstraeten, G., Govers, G., de Vente, J., Nyssen, J., Deckers, J., and Moeyersons, J. 2013. Assessing the performance of a spatially distributed soil erosion and sediment delivery model (WATEM/ SEDEM in Northern Ethiopia. Land Degradation & Development, 24: 188- 204. DOI 10.1002/ldr.1121 Izzo, M., Araujo, N., Aucelli, P. P. C., Maratea, A., and Sánchez, A. 2013. Land sensitivity to Desertification in the Dominican Republic: an adaptation of the ESA methodology. Land Degradation & Development, 24: 486-498. DOI 10.1002/ldr.2241 Kakembo, V., Ndlela, S., and Cammeraat, E. 2012. Trends in vegetation patchiness loss and implications for landscape function: the case of Pteronia incana invasion in the Eastern Cape Province, South Africa. Land Degradation & Development, 23: 548- 556. DOI 10.1002/ldr.2175 Kargar Chigani, H., Khajeddin, S. J. and Karimzadeh, H. R. 2012. Soil relationships of three arid land plant species and their use in rehabilitating degraded sites. Land Degradation & Development, 23: 92- 101. DOI 10.1002/ldr.1057 Kummerrow, J. 1989. Structural aspects of shrubs in Mediterranean type plant communities. In: Bellot, J. (Ed.), Jornadas Sobre las Bases Ecológicas para la Gestión de Ecosistemas Terrestres. Options Méditerranéens. Série Séminaires. CIHEAM IAMZ, Zaragoza, Vol. 3, pp. 5-11. Marques, M.J., Jiménez, L., Pérez-Rodríguez, R., García-Ormaechea, S., Bienes, R. 2005. Reducing water erosion in a gypsic soil by combined use of organic amendment and shrub revegetation. Land Degradation and Development 16, 339-350. Miao, C. Y., Yang, L., Chen, X. H., Gao, Y. 2012. The vegetation cover dynamics (1982-2006) in different erosion regions of the Yellow River Basin, China. Land Degradation & Development, 23: 62- 71. DOI 10.1002/ldr.1050 Poyatos R, Llorens P, Piñol J, Rubio C. 2008. Response of Scots pine (Pinus sylvestris L.) and pubescent oak (Quercus pubescens Willd.) to soil and atmospheric water deficits under Mediterranean mountain climate. Annals of Forest Science 65: 306/301-306/313. DOI: 10.1051/forest:2008003 Prokop, P., Poręba, G. J. 2012. Soil erosion associated with an upland farming system under population pressure in Northeast India. Land Degradation & Development, 23: 310- 321. DOI 10.1002/ldr.2147 Puigdefábregas, J., Mendizábal, T. 1998. Perspectives on desertification: western Mediterranean. Journal of Arid Environments 39, 209-224. Reynolds, J.F., Maestre, F.T., Kemp, P.R., Stafford-Smith, D.M., Lambin, E. 2007. Natural and human dimensions of land degradation in drylands: causes and consequences. In: Canadell, J.G., Pataki, D.E., Pitelka. L.F. (Eds.) Terrestrial Ecosystems in a Changing World, Global Change - The IGBP Series, pp. 247-259. Romero Díaz, A. 2003 Influencia de la litología en las consecuencias del abandono de tierras de cultivo en medio Mediterráneos semiáridos. Papeles de Geografía 38, 151-165. Romero Díaz, A., Belmonte Serrato, F., Ruiz-Sinoga, J.D. 2010. The geomorphic impact of afforestations on soil erosion in Southeast Spain. Land Degradation and Development 21, 188-195.Rowell, 2005 Ruiz Sinoga, J.D., Romero Díaz, A., Ferre Bueno, E., Martínez Murillo, J.F. 2010. The role of soil surface conditions in regulating runoff and erosion processes on a metamorphic hillslope (Southern Spain). Soil surface conditions, runoff and erosion in Southern Spain. Catena 80, 131-139. Tomaselli, R. 1981. Main physiognomic types and geographic distribution of shrub systems related to Mediterranean climates. In: di Castri, F., Goodall, D.W., Specht, R. (Eds.), Ecosystems of the world: Mediterranean-type shrublands. Elsevier, Amsterdam, Netherlands, pp. 95-106. UNEP. 1991. Status of Desertification and Implementation of the United Nations Plan of Action to Combat Desertification. United Nations Environment Programme (UNEP). Nairobi. Zhao, G., Mu, X., Wen, Z., Wang, F., and Gao, P. 2013. Soil erosion, conservation, and Eco-environment changes in the Loess Plateau of China. Land Degradation & Development, 24: 499- 510. DOI 10.1002/ldr.2246 Ziadat, F. M., and Taimeh, A. Y. 2013. Effect of rainfall intensity, slope and land use and antecedent soil moisture on soil erosion in an arid environment. Land Degradation & Development, 24: 582- 590. DOI 10.1002/ldr.2239

The impact of climate change on photovoltaic power generation in Europe

NASA Astrophysics Data System (ADS)

Jerez, Sonia; Tobin, Isabelle; Vautard, Robert; Montávez, Juan Pedro; María López-Romero, Jose; Thais, Françoise; Bartok, Blanka; Bøssing Christensen, Ole; Colette, Augustin; Déqué, Michel; Nikulin, Grigory; Kotlarski, Sven; van Meijgaard, Erik; Teichmann, Claas; Wild, Martin

2016-04-01

Ambitious climate change mitigation plans call for a significant increase in use of renewables, which could, however, make the supply system more vulnerable to climate variability and changes. Here we evaluate climate change impacts on solar photovoltaic (PV) power in Europe using the recent EURO-CORDEX ensemble of high-resolution climate projections together with a PV power production model and assuming a well-developed European PV power fleet. Results indicate that the alteration of solar PV supply by the end of this century compared to the estimations made under current climate conditions should be in the range [-14%;+2%], with the largest decreases in Northern countries. Temporal stability of power generation does not appear as strongly affected in future climate scenarios either, even showing a slight positive trend in Southern countries. Therefore, despite small decreases in production expected in some parts of Europe, climate change is unlikely to threaten the European PV sector. Reference: S. Jerez, I. Tobin, R. Vautard, J.P. Montávez, J.M. López-Romero, F. Thais, B. Bartok, O.B. Christensen, A. Colette, M. Déqué, G. Nikulin, S. Kotlarski, E. van Meijgaard, C. Teichmann and M. Wild (2015). The impact of climate change on photovoltaic power generation in Europe. Nature Communications, 6, 10014, doi: 10.1038/ncomms10014.

Zonda is a novel early component of the autophagy pathway in Drosophila.

PubMed

Melani, Mariana; Valko, Ayelén; Romero, Nuria M; Aguilera, Milton O; Acevedo, Julieta M; Bhujabal, Zambarlal; Perez-Perri, Joel; de la Riva-Carrasco, Rocío V; Katz, Maximiliano J; Sorianello, Eleonora; D'Alessio, Cecilia; Juhász, Gabor; Johansen, Terje; Colombo, María I; Wappner, Pablo

2017-11-01

Autophagy is an evolutionary conserved process by which eukaryotic cells undergo self-digestion of cytoplasmic components. Here we report that a novel Drosophila immunophilin, which we have named Zonda, is critically required for starvation-induced autophagy. We show that Zonda operates at early stages of the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition. Zonda displays an even distribution under basal conditions and, soon after starvation, nucleates in endoplasmic reticulum-associated foci that colocalize with omegasome markers. Zonda nucleation depends on Atg1, Atg13, and Atg17 but does not require Vps34, Vps15, Atg6, or Atg14. Zonda interacts physically with Atg1 through its kinase domain, as well as with Atg6 and Vps34. We propose that Zonda is an early component of the autophagy cascade necessary for Vps34-dependent PI3P deposition and omegasome formation. © 2017 Melani, Valko, Romero, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Empress Sissi and cardiac tamponade: an historical perspective.

PubMed

Meyer, Philippe; Keller, Pierre-Frédéric; Spodick, David H

2008-11-01

On September 10, 1898, Empress Elizabeth of Austria, known as Sissi, was stabbed with a stiletto knife in her chest by an Italian anarchist in Geneva, Switzerland, and died 1 hour later. The autopsy revealed a large clot in the pericardial sac due to a perforation of the left ventricular wall, and the report concluded, "Death was undoubtedly caused by a progressive and slow blood leak, sufficient to compress the heart and to suspend its functions." Since antiquity, wounds of the heart had been considered immediately fatal, until Paré observed a delayed death after a stab to the heart in the 16th century. The physiology of cardiac tamponade was then elucidated by Richard Lower in 1669. However, it was only in the 19th century that the main clinical features of cardiac tamponade were described and the first treatments attempted. Kussmaul identified its most important clinical hallmark, pulsus paradoxus, in 1873 and the term "tamponade of the heart" was coined for the first time by Rose in 1884. Romero and Larrey pioneered the open drainage of the pericardium early in the century, and Rehn performed the first successful surgical suture of a heart wound in 1896. In conclusion, logistics aside, medical knowledge at the end of the 19th century would have been theoretically sufficient to save the empress from death.

Game Demands of Seven-A-Side Soccer in Young Players.

PubMed

Barbero-Alvarez, José C; Gómez-López, Maite; Castagna, Carlo; Barbero-Alvarez, Verónica; Romero, David V; Blanchfield, Anthony W; Nakamura, Fábio Y

2017-07-01

Barbero-Alvarez, JC, Gómez-López, M, Castagna, C, Barbero-Alvarez, V, Romero, DV, Blanchfield, AW, and Nakamura, FY. Game demands of seven-a-side soccer in young players. J Strength Cond Res 31(7): 1771-1779, 2017-The aim of this study was to examine the activity patterns and physiological demands of 7-a-side youth soccer matches across 2 chronological age categories (U12 and U14). Twenty-two soccer players of a national youth soccer academy were investigated. Players of each age category performed 2 training matches (2 × 25 minutes) and were monitored by global positioning system and heart rate monitor units. Players of both categories covered similar total distance (5,348 ± 307 m), at similar mean heart rate values (86 ± 4% of maximum). However, the number of high-intensity runs (82.5 ± 17.4 vs. 69.7 ± 15.2) and total distance covered during sprints (264 ± 207 vs. 128 ± 74 m) were significantly (p ≤ 0.05) higher in U14 compared with U12. The results suggest a highly demanding nature of 7-a-side soccer for skilled players, with physical maturity possibly influencing the match-related high-intensity performance at these ages.

Pentaquark Search with STAR at RHIC

NASA Astrophysics Data System (ADS)

Salur, Sevil

2004-05-01

Several observations of a five-quark bound system, pentaquarks, from various experiments in photon-nucleus, kaon-nucleus, and proton-proton reactions have been reported*. The presence of these states was predicted by Diakonov at al. using chiral soliton models of baryons in 1997. ** The high energies and particle densities resulting from collisions at RHIC are expected to favor pentaquark production. The large acceptance of STAR's Time Projection Chamber is ideal for such rare particle searches. The short lifetimes predicted for pentaquarks require that a mixing technique be used to reconstruct the pentaquarks via their decay products. This technique has already been used successfully by STAR to reconstruct and study short-lived resonances. We report on the progress of the pentaquark search by the STAR collaboration in pp, dAu, and AuAu collisions through one of the decay modes, Θ^+arrow p+K^0. *T.Nakano et al. (LEPS Collaboration) Phys. Rev. Lett. 91, 0122002(2003) *S.Stepanyan et al. (CLAS Collaboration) hep-exp/0307018 *V.V.Barmin at al. (DIANA Collaboration) hep-exp/0304040 **D. Diakonov, V. Petrov and M. Polakov Z.Phys. A359 (1997) 305-314

Revisiting play elements and self-handicapping in play: a comparative ethogram of five Old World monkey species.

PubMed

Petrů, Milada; Spinka, Marek; Charvátová, Veronika; Lhota, Stanislav

2009-08-01

Play behavior has been viewed as a mixture of elements drawn from "serious" behavior, interspersed by ritualized play signals. Two other types of play behaviors have been overlooked: patterns that are dissimilar from any serious behavior and patterns with self-handicapping character, that is, those that put the animal into unnecessary disadvantageous positions or situations. Here the authors show that these 2 types of patterns can constitute a major part of play repertoire. From our own videorecordings and observations, we constructed play ethograms of 5 monkey species (Semnopithecus entellus, Erythrocebus patas, Chlorocebus pygerythrus, Cercopithecus neglectus, and Cercopithecus diana). The authors evaluated the self-handicapping character of each pattern and in Hanuman langurs also the (dis)similarity to serious behavior. Of the 74 patterns in the 5 species, 33 (45%) were judged to have a self-handicapping character. Of 48 patterns observed in langurs, 16 (33%) were totally dissimilar to any serious langur behavior known to us. The authors discuss the possibility that the different types of play elements may have different functions in play. Copyright 2009 APA, all rights reserved.

Remote Semi-State Preparation as SuperDense Quantum Teleportation

NASA Astrophysics Data System (ADS)

Bernstein, Herbert J.

2011-03-01

Recent advances in experimental technique make SuperDense Teleportation (SDT) possible. The effect uses remote state preparation to send more state-specifying parameters per bit than ordinary quantum teleportation (QT) can transmit. SDT uses a maximal entanglement to teleport the relative phases of an {n}-dimensional equimodular state. This means that one can send only {n}-1 of the total (2 n - 2) parameters -- comprising the relative phases and amplitudes -- of a general state. Nevertheless, for {n} >= 3 , SDT sends more of these state-specifying parameters than QT for a given number of classical bits. In the limit of large {n} the ratio is 2 to 1, hence the nomenclature Bennett suggested, SDT, by analogy with Super Dense Coding. Alice's measurements and Bob's transformations are simpler than in QT. The roles of Charles the state chooser, and Diana who deploys it, are different than in QT. I briefly review possible experimental realizations, including two that are under consideration at the present time by an experimental group leading in higher-dimension entanglement work. Supported in part by NSF grants PHY97-22614 & 07-58149 & KITP, UCSB, including an ITP Scholar-ship.

Context effects in the processing of familiar faces.

PubMed

Brennen, T; Bruce, V

1991-01-01

In this paper we report five experiments that investigate the influence of prime faces upon the speed with which familiar faces are recognized and named. Previously, priming had been reported when the prime and target faces were closely associated, e.g., Prince Charles and Princess Diana (Bruce & Valentine, 1986). In Experiment 1 we show that there is a reliable effect of relatedness on a double-familiarity decision, even when the faces are only categorically related, e.g., Kirk Douglas and Clint Eastwood. Then it was shown that such an effect emerges only on a double decision task (Experiments 2 and 3). Experiment 4 showed that on a primed naming task, faces preceded by a categorically related prime were responded to more quickly than those preceded by an unrelated prime, and the effect was due to inhibition. Experiment 5 replicated this effect and also showed that when associatively related primes were used, a facilitatory, and not an inhibitory, effect is found. It is argued that the facilitation of associative priming arises at an earlier locus than the inhibition of categorial priming.

The need for affect: individual differences in the motivation to approach or avoid emotions.

PubMed

Maio, G R; Esses, V M

2001-08-01

The present research developed and tested a new individual-difference measure of the need for affect, which is the motivation to approach or avoid emotion-inducing situations. The first phase of the research developed the need for affect scale. The second phase revealed that the need for affect is related to a number of individual differences in cognitive processes (e.g., need for cognition, need for closure), emotional processes (e.g., affect intensity, repression-sensitization), behavioral inhibition and activation (e.g., sensation seeking), and aspects of personality (Big Five dimensions) in the expected directions, while not being redundant with them. The third phase of the research indicated that, compared to people low in the need for affect, people high in the need for affect are more likely to (a) possess extreme attitudes across a variety of issues, (b) choose to view emotional movies, and (c) become involved in an emotion-inducing event (the death of Princess Diana). Overall, the results indicate that the need for affect is an important construct in understanding emotion-related processes.

Analysis of direct-drive capsule compression experiments on the Iskra-5 laser facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gus'kov, S. Yu.; Demchenko, N. N.; Zhidkov, N. V.

2010-09-15

We have analyzed and numerically simulated our experiments on the compression of DT-gas-filled glass capsules under irradiation by a small number of beams on the Iskra-5 facility (12 beams) at the second harmonic of an iodine laser ({lambda} = 0.66 {mu}m) for a laser pulse energy of 2 kJ and duration of 0.5 ns in the case of asymmetric irradiation and compression. Our simulations include the construction of a target illumination map and a histogram of the target surface illumination distribution; 1D capsule compression simulations based on the DIANA code corresponding to various target surface regions; and 2D compression simulationsmore » based on the NUTCY code corresponding to the illumination conditions. We have succeeded in reproducing the shape of the compressed region at the time of maximum compression and the reduction in neutron yield (compared to the 1D simulations) to the experimentally observed values. For the Iskra-5 conditions, we have considered targets that can provide a more symmetric compression and a higher neutron yield.« less

Problems and agricultural solutions in olive groves

NASA Astrophysics Data System (ADS)

Lozano-García, Beatriz; Parras-Alcántara, Luis

2017-04-01

The most important and extensive crops in the Mediterranean area are olive groves. Within the last 50 years, the surface occupied by olive groves has progressively increased in Spain including more complex topographies, poorer soils and worse climatic conditions. This situation has caused serious problems based on the losses of soil, nutrients and soil quality among others (Lozano-García and Parras-Alcántara, 2014). Therefore, alternative practices that avoid soil erosion and soil degradation must be considered. As a consequence, farmers together with scientist are innovating by the development of different practices in olive groves in order to avoid these problems and to improve soil conditions. There is a huge range of new practices. Some of them are: i. alternative management techniques such as organic farming, no tillage and minimum tillage. These techniques have a positive impact in soils (Parras-Alcántara and Lozano-García, 2014; Fernández-Romero et al., 2016). ii. the addition of different substances on the soil. For example, oil mill by-products that are thus potentially useful as soil amendments since they are effective sources of organic matter and nitrogen, improve soil quality and alleviate the environmental and agronomic limitations of Mediterranean agricultural soils, even those under using conventional tillage (Lozano-García et al., 2011; Lozano-García and Parras-Alcántara, 2013). iii. the use of covers as secondary crops inside the olive grove. These offer secondary benefits derived from alternative crops and soil protection due to fact that in olive groves the main problem is the high quantity of bare surface. With this contribution we want to show the current situation in olive groves and how better results could be obtained when both trustworthy information is available and farmers and scientist work together. REFERENCES Fernández-Romero, M.L., Parras-Alcántara, L., Lozano-García, B., Clark, J.M., Collins, C.D. 2016. Soil quality assessment based on carbon stratification index in different olive grove management practices in Mediterranean areas. Catena 137, 449-458. Lozano-García, B., Parras-Alcántara, L., del Toro Carrillo de Albornoz, M. 2011. Effects of oil mill wastes on surface soil properties, runoff and soil losses in traditional olive groves in southern Spain. Catena 85 (3), 187-193. Lozano-García, B., Parras-Alcántara, L. 2013. Short-term effects of olive mill by-products on soil organic carbon, total N, C: N ratio and stratification ratios in a Mediterranean olive grove. Agriculture, Ecosystems and Environment 165, 68-73. Lozano-García, B., Parras-Alcántara, L. 2014. Variation in soil organic carbon and nitrogen stocks along a toposequence in a traditional mediterranean olive grove. Land Degradation and Development 25 (3), 297-304. Parras-Alcántara, L., Lozano-García, B. 2014. Conventional tillage versus organic farming in relation to soil organic carbon stock in olive groves in Mediterranean rangelands (southern Spain). Solid Earth 5 (1), 299-311.

Shifting agriculture: the main cause of landscape degradation in the Central Spanish Pyrenees

NASA Astrophysics Data System (ADS)

Lasanta, Teodoro; Nadal-Romero, Estela; Errea, Paz

2017-04-01

Cereal agriculture occupied large areas in the Spanish Pyrenees to feed the population in a socio-economic system of limited exchanges with the outside. In the Western valleys, shifting agriculture constitutes the dominant field pattern, representing almost three-quarters of the traditional agricultural space (Lasanta et al., in press). These were cultivated at times of heavy population growth, necessitating steep and stony hillsides with poor soil to be tilled, or the ones that were far away from the village. The fields were created by clearing the vegetation from a slope, then burning it to use the ash as a fertilizer. Cereal was grown for 3-4 years, after which they were abandoned for 20-30 years to recover fertility, and the cycle was repeated. Almost all the fields (99%) using shifting agriculture had been abandoned by the 1950s. This study analyzes the role of the shifting agriculture in soil erosion and landscape degradation. For this purpose, (i) experimental plots, which reproduce the traditional agriculture in the Pyrenees and the abandonment processes, and (ii) the cartography made from the SIOSE (2009), which shows the present land cover 50 years after cropland abandonment, were used. The results show that shifting agriculture caused higher soil losses than other agricultural uses (1.36 kg m-2 yr-1): fallow land (0.87 kg m-2 yr-1), chemically fertilized cereal (0.86 kg m-2 yr-1) and meadow (0.14 kg m-2 yr-1). Also, after land abandonment, soil losses are higher in shifting agriculture (0.78 kg m-2 yr-1) than cereal lands (0.73 kg m-2 yr-1). The burning of the shrub cover and the use of ashes as fertilizer did not contribute to improve the soil quality, which explains both the higher soil losses during the cultivated period and after the abandonment, since slower plant succession occurs. The results obtained from the SIOSE confirm that the change from meadows to shrubland is relatively fast, as a consequence of the low relationship with livestock (minimum disturbances), but the plant succession is slower than in the other agricultural uses. Undoubtedly, the use of marginal areas from agriculture and high soil losses during cultivation justify the presence of highly degraded soils that delay the forest succession. This explains the high stone cover in many slopes and a landscape characterized by shrublands, after more than 60 years of land abandonment. Acknowledgement This research was supported by the DESEMON and ESPAS projects (CGL2014-52135-C3-3-R and CGL2015-65569-R, funded by the MINECO-FEDER). The "Geomorphology and Global Change" and the "Climate, water, global change and natural systems" research groups were financed by the Aragón Government and the European Social Fund (ESF-FSE). Estela Nadal-Romero was the recipient of a "Ramón y Cajal" postdoctoral contract (Spanish Ministry of Economy and Competitiveness). References Lasanta, T., Errea, M.P. & Nadal-Romero, E. (in press). Traditional agrarian landscape in the Mediterranean mountains. A regional and local factors analysis in the Central Spanish Pyrenees. Land Degradation and Development.

New solutions for steady bubbles in a Hele-Shaw cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanveer, S.

1987-03-01

Exact solutions are presented for steadily moving bubbles in a Hele--Shaw cell when the effect of surface tension is neglected. These solutions form a three-parameter family. For specified area, both the speed of the bubble and the distance of its centroid from the channel centerline remain arbitrary when surface tension is ignored. However, numerical evidence suggests that this twofold arbitrariness is removed by the effect of surface tension, i.e., for given bubble area and surface tension, solutions exist only when the bubble velocity and the centroid distance from the channel centerline attain one or more isolated values. From a limitedmore » numerical search, no nonsymmetric solutions could be found; however, a branch of symmetric bubble solutions that was not found in earlier work was found. This branch corresponds to one of the Romero-Vanden-Broeck branch of finger solutions when the bubble size is large. A new procedure for numerical calculations of bubble solutions in the presence of surface tension is presented and is found to work very well for reasonably large bubbles, unlike the previous method of Tanveer (Phys. Fluids 29, 3537 (1986)). The precise power law dependence of bubble velocity on surface tension for small surface tension is explored for bubbles of different area. Agreement is noted with recent analytical results for a finger.« less

[Twins in myth (author's transl)].

PubMed

de Rachewiltz, B; Parisi, P; Castellani, V

1976-01-01

Twins have an important place in mythology and a sacred character appears to be attached to them since the most ancient times. In ancient Egypt, the royal placenta was worshipped, being considered as the Pharao's twin (a conception that is still alive among certain African populations), and actually everyone was considered to possess a spiritual twin, the Ka or astral body, through whom it was supposed to be possible to operate with magic rituals and hit enemies. Twin gods were worshipped by Babylonians and Assyrians (who even introduced them among astronomic constellations), and may be also found in the Persian and Veda religions. In the classic, Greco-Roman world, the examples of twin gods and heroes are innumerable: from the twin sons of Zeus, the Dioscuri, to the opposite-sexed twin gods Apollo and Diana, to Rome's founders, Romulus and Remus, etc. Since the most ancient times, a magic conception is connected to the twins, either in a positive or a negative sense, but often with some kind of a "fatidic" aspect. Such a two-faced approach to the phenomenon of twinning, that variously characterizes near-east, protomediterranean, classic, and other ancient civilizations, may still be found in contemporary primitive societies.

Rules and Laws against Light Pollution in Italy

NASA Astrophysics Data System (ADS)

di Sora, Mario

1999-08-01

Campo Catino astronomical observatory is engaged in fighting light pollution for many years. In Italy, after many years of unjustified inactivity by astronomers and amateurs, a movement of opinion is born intending to resolve this problem definitely. All that through this themes spread at cultural and technical level and, above all, obtaining municipal and regional rules approval and national law. In this field the Campo Catino astronomical observatory distinguishes itself particularly because it has contributed to edit the Bill (No. 751) proposed to the Italian parliament by Senator Lino Diana, (in 1992 and subsequently in 1994 and 1996), it is entitled: "Urgent measures about the fight against light pollution and the induction of power consumption by using external lighting." and, because, Campo Catino observatory has elaborated a rule already approved by several municipalities in Frosinone province (but utilized as example by other Italian municipalities as Florence, Civitavecchia and Piacenza). It proposes to reduce, by five years after its approval, the artificial lights spread high-up and energy consumptions by using appropriate criteria and products. In this presentation the author explains juridical and technical aspects concerning the rules and laws created to fight light pollution in Italy.

Taxonomic revision of Stagmatoptera Burmeister, 1838 (Mantodea: Mantidae, Stagmatopterinae).

PubMed

Rodrigues, Henrique Miranda; Cancello, Eliana Marques

2016-11-01

Stagmatoptera Burmeister, 1838 includes medium to large-sized (49.8-98.7mm) praying mantises distributed in the Neotropical region. They are characterized for having a central, circular spot on each forewing, and 2-4 carinae in the head's frontal shield. This study is an updated revision of the genus on the basis of type and non-type material deposited in various scientific collections from Europe and the Americas. The following nomenclatural procedures were conducted: Stagmatoptera nova is a new junior synonym of Stagmatoptera pia, Stagmatoptera ignota as the junior synonym of Stagmatoptera femoralis, and Stagmatoptera flavipennis is reinstated as the junior synonym of Stagmatoptera supplicaria. Two new species are described: Stagmatoptera diana Rodrigues sp. n. from Colombia and Venezuela, and Stagmatoptera cerdai Rodrigues sp. n. from Trinidad & Tobago and Venezuela. Stagmatoptera now includes 14 species, two of which (Stagmatoptera abdominalis and Stagmatoptera indicator) are considered as species inquirenda. We provide detailed morphological descriptions of all species, a species-level identification key, in addition to abundant visual material to assist identification. Female genitalia, a structure seldom used for taxonomic purposes, was a useful character system to distinguish among species of the genus. Distribution maps for all species are also provided.

MicroRNAs as Potential Regulators of Glutathione Peroxidases Expression and Their Role in Obesity and Related Pathologies.

PubMed

Matoušková, Petra; Hanousková, Barbora; Skálová, Lenka

2018-04-14

Glutathione peroxidases (GPxs) belong to the eight-member family of phylogenetically related enzymes with different cellular localization, but distinct antioxidant function. Several GPxs are important selenoproteins. Dysregulated GPx expression is connected with severe pathologies, including obesity and diabetes. We performed a comprehensive bioinformatic analysis using the programs miRDB, miRanda, TargetScan, and Diana in the search for hypothetical microRNAs targeting 3'untranslated regions (3´UTR) of GPxs. We cross-referenced the literature for possible intersections between our results and available reports on identified microRNAs, with a special focus on the microRNAs related to oxidative stress, obesity, and related pathologies. We identified many microRNAs with an association with oxidative stress and obesity as putative regulators of GPxs. In particular, miR-185-5p was predicted by a larger number of programs to target six GPxs and thus could play the role as their master regulator. This microRNA was altered by selenium deficiency and can play a role as a feedback control of selenoproteins' expression. Through the bioinformatics analysis we revealed the potential connection of microRNAs, GPxs, obesity, and other redox imbalance related diseases.

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

PubMed Central

Zhang, Shui-Jun; Zhao, Chen; Qiu, Bin-Song; Gu, Hai-Feng; Hong, Jian-Fei; Cao, Li; Chen, Yu; Xia, Bing; Bi, Qin; Wang, Ya-Ping

2014-01-01

The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive. Exosomal miRNAs isolated from human bone marrow-derived mesenchymal stem cells (BMSCs) culture were profiled using miRNA arrays containing probes for 894 human matured miRNAs. Seventy-nine miRNAs (∼8.84%) could be detected in exosomes isolated from BMSC culture supernatants when normalized to endogenous control genes RNU44. Among them, nine exosomal miRNAs were up regulated and 4 miRNAs were under regulated significantly (Relative fold>2, p<0.05) when compared with the values at 0 day with maximum changes at 1 to 7 days. Five miRNAs (miR-199b, miR-218, miR-148a, miR-135b, and miR-221) were further validated and differentially expressed in the individual exosomal samples from hBMSCs cultured at different time points. Bioinformatic analysis by DIANA-mirPath demonstrated that RNA degradation, mRNA surveillance pathway, Wnt signaling pathway, RNA transport were the most prominent pathways enriched in quantiles with differential exosomal miRNA patterns related to osteogenic differentiation. These data demonstrated exosomal miRNA is a regulator of osteoblast differentiation. PMID:25503309

Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults' Evaluations of Authentic Objects.

PubMed

Frazier, Brandy N; Gelman, Susan A; Wilson, Alice; Hood, Bruce

2009-01-01

Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults' evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person's attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults.

Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults’ Evaluations of Authentic Objects

PubMed Central

Frazier, Brandy N.; Gelman, Susan A.; Wilson, Alice; Hood, Bruce

2010-01-01

Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults’ evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person’s attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults. PMID:20631919

The social consequences of conspiracism: Exposure to conspiracy theories decreases intentions to engage in politics and to reduce one's carbon footprint.

PubMed

Jolley, Daniel; Douglas, Karen M

2014-02-01

The current studies explored the social consequences of exposure to conspiracy theories. In Study 1, participants were exposed to a range of conspiracy theories concerning government involvement in significant events such as the death of Diana, Princess of Wales. Results revealed that exposure to information supporting conspiracy theories reduced participants' intentions to engage in politics, relative to participants who were given information refuting conspiracy theories. This effect was mediated by feelings of political powerlessness. In Study 2, participants were exposed to conspiracy theories concerning the issue of climate change. Results revealed that exposure to information supporting the conspiracy theories reduced participants' intentions to reduce their carbon footprint, relative to participants who were given refuting information, or those in a control condition. This effect was mediated by powerlessness with respect to climate change, uncertainty, and disillusionment. Exposure to climate change conspiracy theories also influenced political intentions, an effect mediated by political powerlessness. The current findings suggest that conspiracy theories may have potentially significant social consequences, and highlight the need for further research on the social psychology of conspiracism. © 2012 The British Psychological Society.

Double-strangeness production in {bar p}Xe annihilation at low energy in the DIANA chamber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barmin, V.V.; Barylov, V.G.; Chernukha, S.F.

1994-09-01

From the analysis of about 10{sup 5} annihilations of antiprotons at rest and in flight (0.4 - 0.9 GeV/c) on Xe nuclei, new results are presented for the final state K{sup 0}{sub s}SX (S = K{sup 0}{sub s}, K{sup {minus}}, {Lambda}, {Sigma}{sup 0}, {Sigma}{sup +-}). From these results and from earlier results for the final state K{sup +}SX, inclusive and semiinclusive yields are determined, giving virtually all strange channels. The effective strangeness contents were deduced to be 5.5% at rest and 5.3% in flight. In addition to 14 events reported earlier in the final states K{sup +}K{sup +}X and K{supmore » +}K{sup 0}{sub s}{Lambda}X and based on an analysis of 5.4 x 10{sup 5} annihilations, three new events were found in a further analysis of 10{sup 5} annihilations. The new events, together with the revised yields and momentum and mass distributions, are presented. The results confirm earlier results on the effective mass of {Lambda}{Lambda} and a determination of the preferable cascade process.« less

IDPT: Insights into potential intrinsically disordered proteins through transcriptomic analysis of genes for prostate carcinoma epigenetic data.

PubMed

Mallik, Saurav; Sen, Sagnik; Maulik, Ujjwal

2016-07-15

Involvement of intrinsically disordered proteins (IDPs) with various dreadful diseases like cancer is an interesting research topic. In order to gain novel insights into the regulation of IDPs, in this article, we perform a transcriptomic analysis of mRNAs (genes) for transcripts encoding IDPs on a human multi-omics prostate carcinoma dataset having both gene expression and methylation data. In this regard, firstly the genes that consist of both the expression and methylation data, and that are corresponding to the cancer-related prostate-tissue-specific disordered proteins of MobiDb database, are selected. We apply standard t-test for determining differentially expressed genes as well as differentially methylated genes. A network having these genes and their targeter miRNAs from Diana Tarbase v7.0 database and corresponding Transcription Factors from TRANSFAC and ITFP databases, is then built. Thereafter, we perform literature search, and KEGG pathway and Gene Ontology analyses using DAVID database. Finally, we report several significant potential gene-markers (with the corresponding IDPs) that have inverse relationship between differential expression and methylation patterns, and that are hub genes of the TF-miRNA-gene network. Copyright © 2016 Elsevier B.V. All rights reserved.

The Sacred Mountain of Varallo in Italy: seismic risk assessment by acoustic emission and structural numerical models.

PubMed

Carpinteri, Alberto; Lacidogna, Giuseppe; Invernizzi, Stefano; Accornero, Federico

2013-01-01

We examine an application of Acoustic Emission (AE) technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named "The Sacred Mountain of Varallo." Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the "Sacred Mountain of Varallo" and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth's crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects.

Joan Riviere and the masquerade.

PubMed

Hughes, Athol

2004-01-01

Although she published her paper "Womanliness as a masquerade" in 1929, Joan Riviere wrote it in 1928, the year that women in England got the vote. I want to consider the paper, her first original contribution to psychoanalytic thought, in the social and cultural context of the time, and then I shall focus on elements in it that relate to Joan Riviere's personal experiences and family influences that shaped her understanding of women and their sexuality. As well, I shall look at her views in relation to those of Freud, Klein and Jones. There is evidence that Riviere was speaking of herself in her descriptions of the "patient" in her paper, evidence that can be found in her diary and in the diary of her mother; as well as from interviews that I had with her daughter Diana. In addition there is a letter from Freud to Riviere that gives further evidence that she is writing about herself in this paper. The correspondence between Freud and Jones concerning Riviere and her analysis with Freud in 1922 also throws light on her experiences and on her personality that are similar to those of the "patient" she describes in "Womanliness as a masquerade."

[Gynecology and obstetrics in Ancient Rome].

PubMed

Dumont, M

1992-10-01

Gods and Goddesses were invoked by the Romans for the termination of a good delivery. Diana, Juno, Lucina and Cybele were the preferred ones. Sterility was sometimes treated by the whip of the Lupercali of ministers of Pan. The first doctors in Rome were coming from Greece. Celsus, Pliny the Elder were encyclopedists, Rufus an anatomist, Dioscorides a pharmacologist. Archigenes, Aretaeus and Antyllus surgeons. Soranus from Ephesus, was the first to recommend podalic version. His works was a long time buried in a profound oblivion and discovered by scholars during the nineteenth century. Galen was looked as the most famous medical man after Hippocrates. During the Roman Empire of Occident (Byzantine Empire), Oribasius, Aurelianus Caelius, Moschion and above all Aetius and Paul of Aegina wrote many works which were many times plagiarized. Roman laws concerning public health were severe. Midwives took an important action in the care of pregnant women. Roman poets as Plautus, Terence, Lucilius, Catullus, Virgil, Tibullus, Ovid and Martial were many times concerned in their writings with gynecologic or obstetric subjects. Children were easily forsaken. Three Emperors, Trajan, Marcus-Aurelius and Alexander Severius, a writer, Aulu-Gelles, and a rhetor, Quintilian, took protection of them.

Assessment of grass root effects on soil piping in sandy soils using the pinhole test

NASA Astrophysics Data System (ADS)

Bernatek-Jakiel, Anita; Vannoppen, Wouter; Poesen, Jean

2017-04-01

Soil piping is a complex land degradation process, which involves the hydraulic removal of soil particles by subsurface flow. This process is frequently underestimated and omitted in most soil erosion studies. However, during the last decades several studies reported the importance of soil piping in various climatic zones and for a wide range of soil types. Compared to sheet, rill and gully erosion, very few studies focused on the factors controlling piping and, so far, there is no research study dealing with the effects of plant roots on piping susceptibility of soils having a low cohesion. The objective of this study is therefore to assess the impact of grass root density (RD) on soil piping in sandy soils using the pinhole test. The pinhole test involves a water flow passing through a hole of 1 mm diameter in a soil specimen (sampled using a metal ring with a diameter of 5 cm and a length of 8 cm), under varying hydraulic heads (50 mm, 180 mm, 380 mm and 1020 mm; Nadal-Romero et al., 2011). To provide a quantitative assessment piping susceptibility of the soil sample, the pipeflow discharge (cm3 s-1) and the sediment discharge (g s-1) were measured every minute during a five minute test. Bare and root-permeated samples were tested, using a sandy soil with a sand, silt, clay content of respectively, 94%, 4% and 2%. The root-permeated topsoil samples were taken in field plots sown with a mixture of grasses with fibrous roots. All soil samples were placed on a sandbox with a 100 mm head for 24 hours to ensure a similar water content for all samples. In total, 67 pinhole tests (lasting 5 minutes each) were conducted, i.e. 43 root-permeated soil samples with RD ranging from 0.01 to 0.93 kg m-3 and 24 root-free soil samples as a reference. Clear piping erosion could be observed in 65% of the root-free soil samples, whereas only 17% of rooted soil samples revealed clear piping erosion during the tests. Statistical analyses show that there is a negative correlation (-0.41, p < 0.05) between RD and sediment discharge. Mean pipeflow discharge was 1.4 times larger for the root-free samples compared to the root-permeated samples, while mean sediment discharge was 3 times higher for the root-free samples compared to the rooted samples. This indicates that the presence of fibrous roots in topsoils decreases the susceptibility to soil piping significantly. Furthermore, a positive correlation between the hydraulic head (50-1020 mm) and sediment discharge was observed. Overall, our results suggest that root density is a highly relevant factor for decreasing the soil piping erosion rates in the sandy topsoils. The presence of even very low root densities (< 1 kg m3) decrease pipeflow and sediment discharge. A. Bernatek-Jakiel is supported by the ETIUDA doctoral scholarship (UMO-2015/16/T/ST10/00505) financed by the National Science Centre of Poland. Reference: Nadal-Romero, E., Verachtert, E., Maes, R., Poesen, J., 2011. Quantitative assessment of the piping erosion susceptibility of loess-derived soil horizons using the pinhole test. Geomorphology 135, 66-79.

Modelling global change impacts on soil carbon contents of agro-silvo-pastoral Mediterranean systems

NASA Astrophysics Data System (ADS)

Lozano-García, Beatriz; Muñoz-Rojas, Miriam; Parras-Alcántara, Luis

2016-04-01

To assess the impact of climate change on soil organic C (SOC) stocks in agro-silvo-pastoral environments, different models have been applied worldwide at local or regional scales, such as as RothC (Francaviglia et al., 2012) or CENTURY (Alvaro-Fuentes et al., 2012). However, some of these models may require a high number of input parameters or can underestimate the effect of soil depth. CarboSOIL (Muñoz-Rojas et al., 2013) is an empirical model based on regression techniques and developed to predict SOC contents at standard soil depths (0-25, 25-50 and 50-75 cm) under a range of climate and/or land use change scenarios. CarboSOIL has been successfully applied in different Mediterranean areas ,e.g. Southern Spain (Muñoz-Rojas et al., 2013; Abd-Elmabod et al., 2014), Northern Egypt (Muñoz-Rojas et al., 2014) and Italy (Muñoz-Rojas et al., 2015). In this study, CarboSOIL was applied in the Cardeña and Montoro mountain range Natural Park. This area covers 385 km2 and is located within Sierra Morena (Córdoba, South Spain) and has a semiarid Mediterranean climate. It is characterized by agro-silvo-pastoral systems. The Mediterranean evergreen oak woodland (MEOW-dehesa) is savanna-like open woodland ecosystem characterized by silvopastoral uses, being an ancient human modified Mediterranean landscape (Corral-Fernández et al., 2013; Lozano-García and Parras-Alcántara 2013). The most representative soils in the Cardeña and Montoro mountain range Natural Park are Cambisols, Regosols, Leptosols and Fluvisols. These soils are characterized by low fertility, poor physical conditions and marginal capacity for agricultural use, together with low organic matter (OM) content due to climate conditions (semiarid Mediterranean climate) and soil texture (sandy). The model was applied at different soil depths: 0-25, 25-50 and 50-75 cm (Parras-Alcántara et al., 2015) considering land use and climate changes scenarios based on available global climate models (IPPC, 2007). A total of 38 sampling points were selected under two management practices and six different land uses: (1) MEOW-dehesa (D); (2) MEOW-dehesa + some pine trees (D+P); (3) MEOW-dehesa + some cork oaks (D+C); (4) MEOW-dehesa + some gall oaks (D + G); (5) MEOW-dehesa after a clarified process and transformed to olive grove but maintaining isolated oaks (OG) and (6) MEOW-dehesa after a clarified process and transformed to cereal pasture with isolated oaks (C). Preliminary results showed a high heterogeneity of SOC contents along the soil profile for different climate and land use scenarios. The methods used here can be easily implemented in other Mediterranean areas with available information on climate, site, soil and land use. Keywords: CarboSOIL model, land use change, climate change, soil depth, dehesa References: Abd-Elmabod, S.K., Muñoz-Rojas, M., Jordán, A., Anaya-Romero, M., De la Rosa, D., 2014. Modelling soil organic carbon stocks along topographic transects under climate change scenarios using CarboSOIL. Geophys. Res. Abstr. vol. 16 EGU2014-295-1, EGU General Assembly.) Álvaro-Fuentes, J., Easter, M., Paustian, K., 2012. Climate change effects on organic carbon storage in agricultural soils of northeastern Spain. Agric. Ecosyst. Environ. 155, 87-94. Corral-Fernández, R., Parras-Alcántara, L., Lozano-García, B. 2013. Stratification ratio of soil organic C, N and C:N in Mediterranean evergreen oak woodland with conventional and organic tillage. Agric. Ecosyst. Environ. 164, 252-259. Francaviglia, R., Coleman, K., Whitmore, A.P., Doro, L., Urracci, G., Rubino, M., Ledda, L., 2012. Changes in soil organic carbon and climate change - application of the RothC model in agrosilvo-pastoral Mediterranean systems. Agric. Syst. 112, 48- 54. IPCC, 2007. Technical summary. In: Climate Change 2007. Contribution of Working Group III to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change http://www.ipcc.ch/. Lozano-García, B., Parras-Alcántara, L. 2013. Land use and management effects on carbon and nitrogen in Mediterranean Cambisols. Agric. Ecosyst. Environ. 179, 208- 214. Muñoz-Rojas, M., Jordán, A., Zavala, L.M., González-Peñaloza, F.A., De la Rosa, D., Pino-Mejias, R., Anaya-Romero, M., 2013. Modelling soil organic carbon stocks in global change scenarios: a CarboSOIL application. Biogeosciences 10, 8253-8268. Muñoz-Rojas, M., Abd-Elmabod, S.K., Jordán, A., Zavala, L.M., Anaya-Romero, M., De la Rosa, D., 2014. Potential soil organic carbon stocks in semi arid areas under climate change scenarios: an application of CarboSOIL model in northern Egypt. Geophysical Research Abstracts Vol. 16 EGU2014-638-3, EGU General Assembly. Muñoz-Rojas, M., Doro, L., Ledda, L. and Francaviglia, R. 2015. Application of CarboSOIL model to predict the effects of climate change on soil organic carbon stocks in agro-silvo-pastoral Mediterranean management. Agriculture, ecosystems and environment 202, 8-16. Parras-Alcántara, L., Lozano-García, B., Brevik, E.C., Cerdá, A. 2015. Soil organic carbon stocks assessment in Mediterranean natural areas: A comparison of entire soil profiles and soil control sections. Journal of Environmental Management 15, 155-215.

Association between QRS Duration and Obstructive Sleep Apnea

PubMed Central

Gupta, Shuchita; Cepeda-Valery, Beatriz; Romero-Corral, Abel; Shamsuzzaman, Abu; Somers, Virend K.; Pressman, Gregg S.

2012-01-01

Background: Both obstructive sleep apnea (OSA) and prolonged QRS duration are associated with hypertension, heart failure, and sudden cardiac death. However, possible links between QRS duration and OSA have not been explored. Methods: Cross-sectional study of 221 patients who underwent polysomnography at our center. Demographics, cardiovascular risk factors and ECG were collected to explore a relationship between OSA and QRS duration. Results: The apnea-hypopnea index (AHI) was positively correlated with QRS duration (r = 0.141, p = 0.03). Patients were divided into 3 groups: AHI < 5 (61), AHI 5-29 (104), and AHI > 30 (55). The mean QRS duration prolonged significantly as OSA worsened (AHI < 5, 85 ± 9.5; AHI 5-29, 89 ± 11.9; and AHI > 30, 95 ± 19.9 ms, p = 0.001). QRS ≥ 100 ms was present in 12.7% of patients with severe OSA compared with 0% in the rest of the sample (p < 0.0001). After adjustment for age, race, and cardiovascular risk factors, this association remained significant in women but not in men. Conclusion: QRS duration and OSA were significantly associated. Severity of OSA independently predicted prolonged QRS in women but not men. Nevertheless, prolongation of QRS duration in either sex may potentiate arrhythmic risks associated with OSA. Citation: Gupta S; Cepeda-Valery B; Romero-Corral A; Shamsuzzaman A; Somers VK; Pressman GS. Association between QRS duration and obstructive sleep apnea. J Clin Sleep Med 2012;8(6):649-654. PMID:23243398

Two-dimensional phase unwrapping using robust derivative estimation and adaptive integration.

PubMed

Strand, Jarle; Taxt, Torfinn

2002-01-01

The adaptive integration (ADI) method for two-dimensional (2-D) phase unwrapping is presented. The method uses an algorithm for noise robust estimation of partial derivatives, followed by a noise robust adaptive integration process. The ADI method can easily unwrap phase images with moderate noise levels, and the resulting images are congruent modulo 2pi with the observed, wrapped, input images. In a quantitative evaluation, both the ADI and the BLS methods (Strand et al.) were better than the least-squares methods of Ghiglia and Romero (GR), and of Marroquin and Rivera (MRM). In a qualitative evaluation, the ADI, the BLS, and a conjugate gradient version of the MRM method (MRMCG), were all compared using a synthetic image with shear, using 115 magnetic resonance images, and using 22 fiber-optic interferometry images. For the synthetic image and the interferometry images, the ADI method gave consistently visually better results than the other methods. For the MR images, the MRMCG method was best, and the ADI method second best. The ADI method was less sensitive to the mask definition and the block size than the BLS method, and successfully unwrapped images with shears that were not marked in the masks. The computational requirements of the ADI method for images of nonrectangular objects were comparable to only two iterations of many least-squares-based methods (e.g., GR). We believe the ADI method provides a powerful addition to the ensemble of tools available for 2-D phase unwrapping.

Activating Technology for Connected Health in Cancer: Protocol for a Research and Training Program.

PubMed

Mountford, Nicola; Dorronzoro Zubiete, Enrique; Kessie, Threase; Garcia-Zapirain, Begonya; Nuño-Solinís, Roberto; Coyle, David; Munksgaard, Kristin B; Fernandez-Luque, Luis; Rivera Romero, Octavio; Mora Fernandez, Matilde; Valero Jimenez, Pedro; Daly, Ailish; Whelan, Ruth; Caulfield, Brian

2018-01-24

As cancer survival rates increase, the challenge of ensuring that cancer survivors reclaim their quality of life (QoL) becomes more important. This paper outlines the research element of a research and training program that is designed to do just that. Bridging sectors, disciplines, and geographies, it brings together eight PhD projects and students from across Europe to identify the underlying barriers, test different technology-enabled rehabilitative approaches, propose a model to optimize the patient pathways, and examine the business models that might underpin a sustainable approach to cancer survivor reintegration using technology. The program, funded under the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 722012, includes deep disciplinary PhD projects, intersectoral and international secondments, interdisciplinary plenary training schools, and virtual subject-specific education modules. The 8 students have now been recruited and are at the early stages of their projects. CATCH will provide a comprehensive training and research program by embracing all key elements-technical, social, and economic sciences-required to produce researchers and project outcomes that are capable of meeting existing and future needs in cancer rehabilitation. ©Nicola Mountford, Enrique Dorronzoro Zubiete, Threase Kessie, Begonya Garcia-Zapirain, Roberto Nuño-Solinís, David Coyle, Kristin B Munksgaard, Luis Fernandez-Luque, Octavio Rivera Romero, Matilde Mora Fernandez, Pedro Valero Jimenez, Ailish Daly, Ruth Whelan, Brian Caulfield. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 24.01.2018.

Prenatal diagnosis of Chiari malformation with syringomyelia in the second trimester.

PubMed

Iruretagoyena, Jesus Igor; Trampe, Barbara; Shah, Dinesh

2010-02-01

Routine anatomic ultrasound performed in the second trimester has a detection rate of approximately 70-90% for fetal congenital abnormalities (Nyberg and Souter, J Ultrasound Med 2001;6:655-674). The central nervous system abnormalities are one of the most common ones detected. Chiari malformation is among the CNS abnormalities diagnosed in the fetal period (Bianchi et al., Fetology - diagnosis and management of the fetal patient, McGraw-Hill, 2000). The Arnold-Chiari malformation was first described in 1883 by Cleland (Romero et al., Prenatal diagnosis of congenital anomalies, Appleton and Lange, 1988). It is characterised by the prolapse of the hindbrain structures below the level of the foramen magnum. It can be associated with skeletal abnormalities and neurological dysfunction. In type I, a lip of cerebellum is downwardly displaced with the tonsils, but the fourth ventricle remains in the posterior fossa. This condition may coexist with syringomyelia, which is a cyst formation on the cervical portion of the spinal cord (Creasy et al., Maternal fetal medicine principles and practice, 2004). We present a case where Chiari type 1 and syringomyelia detected at 18 weeks of gestation. The reason for referral to our center was an abnormal inward posturing of both upper and lower extremities (minimal gross movement and almost inexistent range of motion on fetal joints). On further fetal evaluation, an abnormal brain ultrasound was identified. Prenatal diagnosis of Chiari type 1 malformation and syringomyelia is almost nonexistent when reviewing the literature is the reason why this case is presented.

Differences in clinical intrusive thoughts between obsessive-compulsive disorder, generalized anxiety disorder, and hypochondria.

PubMed

Romero-Sanchiz, Pablo; Nogueira-Arjona, Raquel; Godoy-Ávila, Antonio; Gavino-Lázaro, Aurora; Freeston, Mark H

2017-11-01

Differences and similarities between intrusive thoughts typical of obsessive-compulsive disorder, generalized anxiety disorder, and hypochondriasis are relevant for their differential diagnosis, formulation, and psychological treatment. Previous research in non-clinical samples pointed out the relevance of some process variables, such as responsibility, guilt, or neutralization strategies. This research is aimed to investigate the differences and similarities between clinical obsessions, worries, and illness intrusions in some of these process variables. A second aim is to identify models based on these variables that could reliably differentiate between them. Three groups of patients with obsessive-compulsive disorder (n = 35; 60% women, mean age 38.57), generalized anxiety disorder (n = 36; 61.1% women, mean age 41.50), and hypochondriasis (n = 34; 70.6% women, mean age 31.59) were evaluated using the Cognitive Intrusions Questionnaire-Transdiagnostic Version (Romero-Sanchiz, Nogueira-Arjona, Godoy-Ávila, Gavino-Lázaro, & Freeston, ). The results showed that some appraisals (e.g., responsibility or egodystonicity), emotions (e.g., guilt or insecurity), neutralization strategies, and other variables (e.g., verbal content or trigger from body sensation) are relevant for the discrimination between obsessions, worries, and illness intrusions. The results also showed 3 stable models based on these variables for the discrimination between these thoughts. The implication of these results in the diagnosis, formulation, and psychological treatment of obsessive-compulsive disorder, generalized anxiety disorder, and hypochondriasis is discussed. Copyright © 2017 John Wiley & Sons, Ltd.

A kinematic classification of the cosmic web

NASA Astrophysics Data System (ADS)

Hoffman, Yehuda; Metuki, Ofer; Yepes, Gustavo; Gottlöber, Stefan; Forero-Romero, Jaime E.; Libeskind, Noam I.; Knebe, Alexander

2012-09-01

A new approach for the classification of the cosmic web is presented. In extension of the previous work of Hahn et al. and Forero-Romero et al., the new algorithm is based on the analysis of the velocity shear tensor rather than the gravitational tidal tensor. The procedure consists of the construction of the shear tensor at each (grid) point in space and the evaluation of its three eigenvectors. A given point is classified to be either a void, sheet, filament or a knot according to the number of eigenvalues above a certain threshold, 0, 1, 2 or 3, respectively. The threshold is treated as a free parameter that defines the web. The algorithm has been applied to a dark matter only simulation of a box of side length 64 h-1 Mpc and N = 10243 particles within the framework of the 5-year Wilkinson and Microwave Anisotropy Probe/Λ cold dark matter (ΛCDM) model. The resulting velocity-based cosmic web resolves structures down to ≲0.1 h-1 Mpc scales, as opposed to the ≈1 h-1 Mpc scale of the tidal-based web. The underdense regions are made of extended voids bisected by planar sheets, whose density is also below the mean. The overdense regions are vastly dominated by the linear filaments and knots. The resolution achieved by the velocity-based cosmic web provides a platform for studying the formation of haloes and galaxies within the framework of the cosmic web.

Stardial -- an autonomous astronomical camera on the WWW

NASA Astrophysics Data System (ADS)

McCullough, P. R.; Thakkar, U.

1997-05-01

The use of an autonomous electronic camera, called ``Stardial,'' for undergraduate instruction is described. Stardial delivers images of the night sky nearly in real-time to the world wide web (www.astro.uiuc.edu/stardial/). The remote instrumentation of Stardial is robust, inexpensive, and accomodates many students asynchronously with respect to the instructor(s). The guiding philosophy of the curriculum is to provide students with authentic astronomical data so that they may learn about science by doing it themselves on the internet. Students respond favorably to the opportunity to learn from their own experiences with genuine data, complete with its irregularities and its surprises. Perhaps surprisingly, 9 of 10 self-selected student volunteers in our pilot project were female. Stardial's instrumentation is similar to that of Gaustad et al., and to that of Richmond, Droege, et al. (both at this same meeting). Stardial has benefitted from contributions from students, especially Lawrence Tan, Troy Klyber, Jim Pulokas, Jim Waldemer, and Diana Lopez, and from a number of professionals, especially G.T. Becker, Mike Newberry, John Dolby, Tom Droege, Bob Mutel, Mike Richmond, John Thorstensen, and Rick White. Stardial is funded by the University of Illinois, primarily from the office of the Vice President for Academic Affairs. We welcome participation from amateur astronomers and other educators.

Observations of lightning in convective supercells within tropical storms and hurricanes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lyons, W.A.; Keen, C.S.

1994-08-01

Cloud-to-ground (CG) lightning observations from land-based lightning detection networks now allow monitoring this component of the electrical structure of tropical storms and hurricanes within a few hundred kilometers of the United States coastline. Several case studies confirm the long-held opinion that lightning is rather common within the outer rainbands. The general absence of CG lightning within the interior of mature tropical cyclones is also apparent. On the other hand, bursts of CG lightning near the circulation center of developing storms appear to precede periods of further deepening. The CG events are associated with convective supercells, whose anvil canopies can oftenmore » obscure much of the underlying storm. Near-eyewall CG bursts preceding periods of intensification were noted in Hurricanes Diana (1984) and Florence (1988). A detailed case study of the 1987 unnamed tropical storm that struck the Texas-Louisiana coastline reveals that lightning was associated with two large supercells. These supercells appeared to be the trigger for the development of a closed circulation that formed several hours after the apparent low pressure center made landfall. Further studies of lightning may provide additional insight into the role of convective supercells in tropical storm intensification. It may also provide a useful diagnostic of impending deepening.« less

Acoustic Sensor Planning for Gunshot Location in National Parks: A Pareto Front Approach

PubMed Central

González-Castaño, Francisco Javier; Alonso, Javier Vales; Costa-Montenegro, Enrique; López-Matencio, Pablo; Vicente-Carrasco, Francisco; Parrado-García, Francisco J.; Gil-Castiñeira, Felipe; Costas-Rodríguez, Sergio

2009-01-01

In this paper, we propose a solution for gunshot location in national parks. In Spain there are agencies such as SEPRONA that fight against poaching with considerable success. The DiANa project, which is endorsed by Cabaneros National Park and the SEPRONA service, proposes a system to automatically detect and locate gunshots. This work presents its technical aspects related to network design and planning. The system consists of a network of acoustic sensors that locate gunshots by hyperbolic multi-lateration estimation. The differences in sound time arrivals allow the computation of a low error estimator of gunshot location. The accuracy of this method depends on tight sensor clock synchronization, which an ad-hoc time synchronization protocol provides. On the other hand, since the areas under surveillance are wide, and electric power is scarce, it is necessary to maximize detection coverage and minimize system cost at the same time. Therefore, sensor network planning has two targets, i.e., coverage and cost. We model planning as an unconstrained problem with two objective functions. We determine a set of candidate solutions of interest by combining a derivative-free descent method we have recently proposed with a Pareto front approach. The results are clearly superior to random seeding in a realistic simulation scenario. PMID:22303135

The Sacred Mountain of Varallo in Italy: Seismic Risk Assessment by Acoustic Emission and Structural Numerical Models

PubMed Central

Carpinteri, Alberto; Invernizzi, Stefano; Accornero, Federico

2013-01-01

We examine an application of Acoustic Emission (AE) technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named “The Sacred Mountain of Varallo.” Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the “Sacred Mountain of Varallo” and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth's crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects. PMID:24381511

Metabolite profiling of sesquiterpene lactones from Lactuca species. Major latex components are novel oxalate and sulfate conjugates of lactucin and its derivatives.

PubMed

Sessa, R A; Bennett, M H; Lewis, M J; Mansfield, J W; Beale, M H

2000-09-01

Wounding leaves or stems of Lactuca species releases a milky latex onto the plant surface. We have examined the constituents of latex from Lactuca sativa (lettuce) cv. Diana. The major components were shown to be novel 15-oxalyl and 8-sulfate conjugates of the guaianolide sesquiterpene lactones, lactucin, deoxylactucin, and lactucopicrin. The oxalates were unstable, reverting to the parent sesquiterpene lactone on hydrolysis. Oxalyl derivatives have been reported rarely from natural sources. The sulfates were stable and are the first reported sesquiterpene sulfates from plants. Unusual tannins based on 4-hydroxyphenylacetyl conjugates of glucose were also identified. Significant qualitative and quantitative variation was found in sesquiterpene lactone profiles in different lettuce varieties and in other Lactuca spp. The proportions of each conjugate in latex also changed depending on the stage of plant development. A similar profile was found in chicory, in which oxalyl conjugates were identified, but the 8-sulfate conjugates were notably absent. The presence of the constitutive sesquiterpene lactones was not correlated with resistance to pathogens but may have a significant bearing on the molecular basis of the bitter taste of lettuce and related species. The induced sesquiterpene lactone phytoalexin, lettucenin A, was found in the Lactuca spp. but not in chicory.

Where we were in 1998, and how this legacy shaped the next 20 years

NASA Astrophysics Data System (ADS)

Moran, E. F.

2017-12-01

When the National Research Council Committee on Human Dimensions of Global Change decided to convene a gathering of social scientists and remote sensing researchers in 1997 we wanted to know the state-of-knowledge and particularly what challenges those who were beginning to make this linkage had found. Diana Liverman as Chair of the Committee invited Emilio Moran and Ronald Rindfuss from UNC to join her and Paul Stern, from NRC, to organize the meeting, and the resulting volume with support from NASA. In 1997 we were just getting started. Most of us at the meeting had just engaged remote sensing in the past 5 years or so, and each team invited had very different approaches to how to make this linkage (do all have to know and do RS? Or is there a clear division of labor between the social and the remote? The meeting and the intro and concluding chapter of People and Pixels provided a roadmap for the future. This paper will discuss which directions proved to be most significant in advancing this linkage, and what surprises have emerged along the way to advance the linking of remote sensing approaches with the questions that interest social science and the global environmental change community.

Acoustic sensor planning for gunshot location in national parks: a pareto front approach.

PubMed

González-Castaño, Francisco Javier; Alonso, Javier Vales; Costa-Montenegro, Enrique; López-Matencio, Pablo; Vicente-Carrasco, Francisco; Parrado-García, Francisco J; Gil-Castiñeira, Felipe; Costas-Rodríguez, Sergio

2009-01-01

In this paper, we propose a solution for gunshot location in national parks. In Spain there are agencies such as SEPRONA that fight against poaching with considerable success. The DiANa project, which is endorsed by Cabaneros National Park and the SEPRONA service, proposes a system to automatically detect and locate gunshots. This work presents its technical aspects related to network design and planning. The system consists of a network of acoustic sensors that locate gunshots by hyperbolic multi-lateration estimation. The differences in sound time arrivals allow the computation of a low error estimator of gunshot location. The accuracy of this method depends on tight sensor clock synchronization, which an ad-hoc time synchronization protocol provides. On the other hand, since the areas under surveillance are wide, and electric power is scarce, it is necessary to maximize detection coverage and minimize system cost at the same time. Therefore, sensor network planning has two targets, i.e., coverage and cost. We model planning as an unconstrained problem with two objective functions. We determine a set of candidate solutions of interest by combining a derivative-free descent method we have recently proposed with a Pareto front approach. The results are clearly superior to random seeding in a realistic simulation scenario.

Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire

PubMed Central

Anoh, Augustin Etile; Murthy, Sripriya; Akoua-Koffi, Chantal; Couacy-Hymann, Emmanuel; Leendertz, Fabian Hubertus; Calvignac-Spencer, Sébastien; Ehlers, Bernhard

2017-01-01

Cytomegaloviruses (CMVs) are known to infect many mammals, including a number of nonhuman primates (NHPs). However, most data available arose from studies led on captive individuals and little is known about CMV diversity in wild NHPs. Here, we analyzed a community of wild nonhuman primates (seven species) in Taï National Park (TNP), Côte d’Ivoire, with two PCR systems targeting betaherpesviruses. CMV DNA was detected in 17/87 primates (4/7 species). Six novel CMVs were identified in sooty mangabeys, Campbell’s monkeys and Diana monkeys, respectively. In 3/17 positive individuals (from three NHP species), different CMVs were co-detected. A major part of the glycoprotein B coding sequences of the novel viruses was amplified and sequenced, and phylogenetic analyses were performed that included three previously discovered CMVs of western red colobus from TNP and published CMVs from other NHP species and geographic locations. We find that, despite this locally intensified sampling, NHP CMVs from TNP are completely host-specific, pinpointing the absence or rarity of cross-species transmission. We also show that on longer timescales the evolution of CMVs is characterized by frequent co-divergence with their hosts, although other processes, including lineage duplication and host switching, also have to be invoked to fully explain their evolutionary relationships. PMID:29286318

[The woman in neurosurgery at the national institute of neurology and neurosurgery].

PubMed

Mejía-Pérez, Sonia Iliana; Cervera-Martínez, Claudia; Sánchez-Correa, Thalía Estefanía; Corona-Vázquezo, Teresa

Women have always had a hard time in the history of medicine; Dr. Isabel Blackwell was the first woman in history to practice medicine. Dr. Diana Beck became the world´s first female neurosurgeon. The first Latin American female neurosurgeon was Dr. María Cristina García Sancho y Álvarez-Tostado. All of these women had to face a large number of social, cultural, and economic obstacles in their path; however, this situation has changed gradually. Dr. Ana Lilia Siordia Karam was the first neurosurgeon to graduate from INNN. Nineteen years later the second female neurosurgeon at this institute was Dr. María Petra Herrera Guerrero. During their time at this institute they endured a lot of difficulties, especially with most of their coworkers; however, some coworkers treated them with respect and no gender distinction. Nowadays, four of the 25 total neurosurgery residents at INNN are women, and even though some of them have had to endure acts of gender discrimination, the general situation has changed. With work and respect, women have managed to have a larger role in the surgical field. We hope that in the near future a gender discrimination-free environment will be achieved in medicine and its specialties.

Quantum Effects in Biology

NASA Astrophysics Data System (ADS)

Mohseni, Masoud; Omar, Yasser; Engel, Gregory S.; Plenio, Martin B.

2014-08-01

List of contributors; Preface; Part I. Introduction: 1. Quantum biology: introduction Graham R. Fleming and Gregory D. Scholes; 2. Open quantum system approaches to biological systems Alireza Shabani, Masoud Mohseni, Seogjoo Jang, Akihito Ishizaki, Martin Plenio, Patrick Rebentrost, Alàn Aspuru-Guzik, Jianshu Cao, Seth Lloyd and Robert Silbey; 3. Generalized Förster resonance energy transfer Seogjoo Jang, Hoda Hossein-Nejad and Gregory D. Scholes; 4. Multidimensional electronic spectroscopy Tomáš Mančal; Part II. Quantum Effects in Bacterial Photosynthetic Energy Transfer: 5. Structure, function, and quantum dynamics of pigment protein complexes Ioan Kosztin and Klaus Schulten; 6. Direct observation of quantum coherence Gregory S. Engel; 7. Environment-assisted quantum transport Masoud Mohseni, Alàn Aspuru-Guzik, Patrick Rebentrost, Alireza Shabani, Seth Lloyd, Susana F. Huelga and Martin B. Plenio; Part III. Quantum Effects in Higher Organisms and Applications: 8. Excitation energy transfer in higher plants Elisabet Romero, Vladimir I. Novoderezhkin and Rienk van Grondelle; 9. Electron transfer in proteins Spiros S. Skourtis; 10. A chemical compass for bird navigation Ilia A. Solov'yov, Thorsten Ritz, Klaus Schulten and Peter J. Hore; 11. Quantum biology of retinal Klaus Schulten and Shigehiko Hayashi; 12. Quantum vibrational effects on sense of smell A. M. Stoneham, L. Turin, J. C. Brookes and A. P. Horsfield; 13. A perspective on possible manifestations of entanglement in biological systems Hans J. Briegel and Sandu Popescu; 14. Design and applications of bio-inspired quantum materials Mohan Sarovar, Dörthe M. Eisele and K. Birgitta Whaley; 15. Coherent excitons in carbon nanotubes Leonas Valkunas and Darius Abramavicius; Glossary; References; Index.

Geomorphological processes in a semiarid badland area using new technologies: TLS, terrestrial and aerial SfM photogrammetry

NASA Astrophysics Data System (ADS)

Ferrer, Victor; Errea, Paz; Alonso, Esteban; Gómez-Gutiérrez, Álvaro; Nadal-Romero, Estela

2017-04-01

We used three different methods Terrestrial Laser Scanner (TLS), terrestrial Structure from Motion photogrammetry (SfM) and aerial SfM photogrammetry with an Unmanned Aerial Vehicle (UAV) to analyse geomorphological processes in a semiarid badland landscape. Los Aguarales badlands, located in the Ebro Depression (Spain), occur in the Holocene sediment accumulated in a wide valley infilled with silt and clay. The morphology of Los Aguarales badlands is complex, making the geomorphological interpretation a difficult task. Los Aguarales badlands are characterized by the sequence of incision and piping processes developing an abrupt and complex landscape. Three different representative and small study sites were selected to carry out a detailed analysis of the geomorphological processes. Moreover, the capability of the three methods to produce high resolution point clouds was evaluated. The obtained topographical changes were very low during the first 6 months (March-October 2016). Measured topographical changes, with TLS and terrestrial SfM, were very low, and these values fall within the range of the acquisition error of the devices used (2-6 cm). The preliminary results indicated the possibilities of a multiscale approach using new technologies to study geomorphological and erosion processes, although long-term studies will be necessary to obtain erosion rates in this semiarid badland area. Acknowledgement This research was supported by ESPAS and eTERA 3D projects (CGL2015- 65569-R and CGL2014-54822-R, funded by the MINECO-FEDER). Estela Nadal-Romero is the recipient of a Ramón y Cajal postdoctoral contract (Spanish Ministry of Economy and Competitiveness).

Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4

PubMed Central

Maddipati, Krishna Rao; Romero, Roberto; Chaiworapongsa, Tinnakorn; Chaemsaithong, Piya; Zhou, Sen-Lin; Xu, Zhonghui; Tarca, Adi L.; Kusanovic, Juan Pedro; Gomez, Ricardo; Chaiyasit, Noppadol; Honn, Kenneth V.

2016-01-01

Bioactive lipids derived from the metabolism of polyunsaturated fatty acids are important mediators of the inflammatory response. Labor per se is considered a sterile inflammatory process. Intra-amniotic inflammation (IAI) due to microorganisms (i.e., intra-amniotic infection) or danger signals (i.e., sterile IAI) has been implicated in the pathogenesis of preterm labor and clinical chorioamnionitis at term. Early and accurate diagnosis of microbial invasion of the amniotic cavity (MIAC) requires analysis of amniotic fluid (AF). It is possible that IAI caused by microorganisms is associated with a stereotypic lipidomic profile, and that analysis of AF may help in the identification of patients with this condition. To test this hypothesis, we analyzed the fatty acyl lipidome of AF by liquid chromatography—mass spectrometry from patients in spontaneous labor at term and preterm gestations. We report that the AF concentrations of proinflammatory lipid mediators of the 5-lipoxygenase pathway are significantly higher in MIAC than in cases of sterile IAI. These results suggest that the concentrations of 5-lipoxygenase metabolites of arachidonic acid, 5-hydroxyeicosatetraenoic acid, and leukotriene B4 in particular could serve as potential biomarkers of MIAC. This finding could have important implications for the rapid identification of patients who may benefit from anti-microbial treatment.—Maddipati, K. R., Romero, R., Chaiworapongsa ,T., Chaemsaithong, P., Zhou, S.-L., Xu, Z., Tarca, A. L., Kusanovic, J. P., Gomez, R., Chaiyasit, N., Honn, K. V. Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4. PMID:27312808

Chlorophyll a and turbidity patterns over coral reefs systems of La Parguera Natural Reserve, Puerto Rico.

PubMed

Otero, Emesto; Carbery, Kelly K

2005-05-01

Studies of temporal and spatial changes in phytoplankton biomass and turbidity provide essential information on coral reef ecosystem function and health. Fluctuation of phytoplankton biomass responds to several factors including nutrient inputs, both anthropogenic and natural, while turbidity is mostly affected by sediment resuspension or transport from terrestrial systems. These parameters can be used as sentinels of significant environmental factors "modifying" coral reef systems. A chlorophyll a concentration (Chl a) and turbidity (Turb) in situ logger was installed at 10 stations from June 4 to July 7, 2003 in La Parguera Natural Reserve (Southwestern Puerto Rico) to assess short-term temporal and geographic variation in patterns of phytoplankton biomass and turbidity at pre-selected sites as part of an interdisciplinary long-term study. Average station Ch1 a variation was 0.17-1.12 microg 1(-1) and 0.2-23.4 NTU for Turb. Results indicate that the western near-coastal stations had higher levels of Turb and Ch1 a. The easternmost mid shelf station, Romero reef, was similar to coastal stations probably due to nutrient and suspended sediment inputs from a source external to our study area to the east, Guánica Bay. Comparisons between different sampling days indicate significant differences between days for most stations suggesting that one-time discrete sampling may not be representative of average water column conditions and illustrate the dynamic nature of coral reef systems. Further work is warranted to assess seasonal changes that integrate short-term (daily) variability in both Turb and Ch1 a.

Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease

PubMed Central

Prado, Gregory N.; Romero, Jose R.; Rivera, Alicia

2013-01-01

Increased endothelin-1 (ET-1) levels, disordered thiol protein status, and erythrocyte hydration status play important roles in sickle cell disease (SCD) through unresolved mechanisms. Protein disulfide isomerase (PDI) is an oxidoreductase that mediates thiol/disulfide interchange reactions. We provide evidence that PDI is present in human and mouse erythrocyte membranes and that selective blockade with monoclonal antibodies against PDI leads to reduced Gardos channel activity (1.6±0.03 to 0.56±0.02 mmol·1013 cell−1·min−1, P<0.001) and density of sickle erythrocytes (D50: 1.115±0.001 to 1.104±0.001 g/ml, P=0.012) with an IC50 of 4 ng/ml. We observed that erythrocyte associated-PDI activity was increased in the presence of ET-1 (3.1±0.2 to 5.6±0.4%, P<0.0001) through a mechanism that includes casein kinase II. Consistent with these results, in vivo treatment of BERK sickle transgenic mice with ET-1 receptor antagonists lowered circulating and erythrocyte associated-PDI activity (7.1±0.3 to 5.2±0.2%, P<0.0001) while improving hematological parameters and Gardos channel activity. Thus, our results suggest that PDI is a novel target in SCD that regulates erythrocyte volume and oxidative stress and may contribute to cellular adhesion and endothelial activation leading to vasoocclusion as observed in SCD.—Prado, G. N., Romero, J. R., Rivera, A. Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease. PMID:23913858

Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor

PubMed Central

Maddipati, Krishna Rao; Romero, Roberto; Chaiworapongsa, Tinnakorn; Zhou, Sen-Lin; Xu, Zhonghui; Tarca, Adi L.; Kusanovic, Juan Pedro; Munoz, Hernan; Honn, Kenneth V.

2014-01-01

Lipid mediators play an important role in reproductive biology, especially, in parturition. Enhanced biosynthesis of eicosanoids, such as prostaglandin E2 (PGE2) and PGF2α, precedes the onset of labor as a result of increased expression of inducible cyclooxygenase 2 (COX-2) in placental tissues. Metabolism of arachidonic acid results in bioactive lipid mediators beyond prostaglandins that could significantly influence myometrial activity. Therefore, an unbiased lipidomic approach was used to profile the arachidonic acid metabolome of amniotic fluid. In this study, liquid chromatography–mass spectrometry was used for the first time to quantitate these metabolites in human amniotic fluid by comparing patients at midtrimester, at term but not in labor, and at term and in spontaneous labor. In addition to exposing novel aspects of COX pathway metabolism, this lipidomic study revealed a dramatic increase in epoxygenase- and lipoxygenase-pathway-derived lipid mediators in spontaneous labor with remarkable product selectivity. Despite their recognition as anti-inflammatory lipid mediators and regulators of ion channels, little is known about the epoxygenase pathway in labor. Epoxygenase pathway metabolites are established regulators of vascular homeostasis in cardiovascular and renal physiology. Their presence as the dominant lipid mediators in spontaneous labor at term portends a yet undiscovered physiological function in parturition.—Maddipati, K. R., Romero, R., Chaiworapongsa, T., Zhou, S.-L., Xu, Z., Tarca, A. L., Kusanovic, J. P., Munoz, H., Honn, K. V. Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor. PMID:25059230

PHYSICS EDUCATION AND THE INTERNET: A beginner's guide to a physicist starting out on an Internet journey

NASA Astrophysics Data System (ADS)

Burton, Paul

1998-05-01

Thirty useful physics-related sites are listed to help get you started. I hope you will find some of the following sites of use in your teaching or good for pointing your pupils in the right direction when doing research. I have not attempted to rank or sort them in any order. However, by the time you read this issue of Physics Education some of the sites may not be available; this is the nature of the net. Those not wishing to retype each address can access them from my school's physics page (http://www.bootham.demon.co.uk/physics/links.html) or e-mail me at pkb@bootham.demon.co.uk and I can send you a document with the hypertext live links in. The new IOP sponsored 16-19 Physics project is promising great things with its own Internet site. You will be able to download information, updates, worksheets etc. Any queries about the development of this project at present can be sent to Evelyn van Dyk at: 16-19project@iop.org Engineering and Physical Sciences Research Councilhttp://www.epsrc.ac.uk Particle Physics and Astronomy Research Councilhttp://www.pparc.ac.uk American Institute of Physicshttp://www.aip.org Usenet Physics FAQ (frequently asked questions)http://www.weburbia.demon.co.uk/physics/faq.html CERNhttp://www.cern.ch/ BBC Educationhttp://www.bbc.co.uk/education/ Useful data on the Periodic Tablehttp://www.shef.ac.uk/chemistry/web-elements/ JET WWW index page:http://www.jet.uk NERC satellite station, Dundee Universityhttp://www.sat.dundee.ac.uk/ The Meteorological Officehttp://www.meto.govt.uk/ The Smithsonian Institute, Washington, DChttp://www.si.edu/newstart.htm Frequently asked questions on time and frequencyhttp://www.boulder.nist.gov/timefreq/faq/faq.htm Physics newshttp://www.het.brown.edu/news/index.html TIPTOP: The Internet Pilot to Physicshttp://www.tp.umu.se/TIPTOP/ A Dictionary of Scientific Quotationshttp://naturalscience.com/dsqhome.html ScI-Journal: an on-line publication for science studentshttp://www.soton.ac.uk/~plf/ScI-Journal/ Science On-linehttp://www.shu.ac.uk/schools/sci/sol/contents.htm Physics humourhttp://quark.physics.uwo.ca/~harwood/humor12.htm Searching for someone's e-mail address?http://www.four11.com SKY publicationshttp://www.skypub.com Planet Sciencehttp://www.keysites.com New Scientisthttp://www.newscientist.com NASA links to the American space programhttp://www.nasa.gov NASA Jet Propulsion Laboratoryhttp://www.jpl.nasa.gov Hewlett-Packardhttp://www.hp.com The Bradford Schools Telescope Projecthttp://www.telescope.org/rti/nuffield/ To contact a professional societyhttp://www.lib.uwaterloo.ca/society/overview.html The Schools' Physics Group: post-16 issueshttp://diana.ecs.soton.ac.uk/~pm/Physics/post16.html Sleuth search for physics and chemistryhttp://www.isleuth.com/index.shtml The Particle Adventurehttp://pdg.lbl.gov/cpep/adventure_home.html Acknowledgments I thank colleagues David Robinson and Robin Peach for their help in selecting and validating these sites and William Try, pupil at Bootham School, for preparing and maintaining the department's homepage with hypertext links. Received 21 January 1998

Identification of land degradation evidences in an organic farm using probability maps (Croatia)

NASA Astrophysics Data System (ADS)

Pereira, Paulo; Bogunovic, Igor; Estebaranz, Ferran

2017-04-01

Land degradation is a biophysical process with important impacts on society, economy and policy. Areas affected by land degradation do not provide services in quality and with capacity to full-field the communities that depends on them (Amaya-Romero et al., 2015; Beyene, 2015; Lanckriet et al., 2015). Agricultural activities are one of the main causes of land degradation (Kraaijvanger and Veldkamp, 2015), especially when they decrease soil organic matter (SOM), a crucial element for soil fertility. In temperate areas, the critical level of SOM concentration in agricultural soils is 3.4%. Below this level there is a potential decrease of soil quality (Loveland and Weeb, 2003). However, no previous work was carried out in other environments, such as the Mediterranean. The spatial distribution of potential degraded land is important to be identified and mapped, in order to identify the areas that need restoration (Brevik et al., 2016; Pereira et al., 2017). The aim of this work is to assess the spatial distribution of areas with evidences of land degradation (SOM bellow 3.4%) using probability maps in an organic farm located in Croatia. In order to find the best method, we compared several probability methods, such as Ordinary Kriging (OK), Simple Kriging (SK), Universal Kriging (UK), Indicator Kriging (IK), Probability Kriging (PK) and Disjunctive Kriging (DK). The study area is located on the Istria peninsula (45°3' N; 14°2' E), with a total area of 182 ha. One hundred eighty-two soil samples (0-30 cm) were collected during July of 2015 and SOM was assessed using wet combustion procedure. The assessment of the best probability method was carried out using leave one out cross validation method. The probability method with the lowest Root Mean Squared Error (RMSE) was the most accurate. The results showed that the best method to predict the probability of potential land degradation was SK with an RMSE of 0.635, followed by DK (RMSE=0.636), UK (RMSE=0.660), OK (RMSE=0.660), IK (RMSE=0.722) and PK (RMSE=1.661). According to the most accurate method, it is observed that the majority of the area studied has a high probability to be degraded. Measures are needed to restore this area. References Amaya-Romero, M., Abd-Elmabod, S., Munoz-Rojas, M., Castellano, G., Ceacero, C., Alvarez, S., Mendez, M., De la Rosa, D. (2015) Evaluating soil threats under climate change scenarios in the Andalusia region, Southern Spain. Land Degradation and Development, 26, 441-449. Beyene, F. (2015) Incentives and challenges in community based rangeland management: Evidence from Eastern Ethiopia. Land Degradation and Development, 26, 502-509. Brevik, E., Calzolari, C., Miller, B., Pereira, P., Kabala, C., Baumgarten, A., Jordán, A. (2016) Historical perspectives and future needs in soil mapping, classification and pedological modelling, Geoderma, 264, Part B, 256-274. Kraaijvanger, R., Veldkamp, T. (2015) Grain productivity, fertilizer response and nutrient balance of farming systems in Tigray, Ethiopia: A Multiprespective view in relation do soil fertility degradation. Land Degradation and Development, 26, 701-710. Lanckriet, S., Derudder, B., Naudts, J., Bauer, H., Deckers, J., Haile, M., Nyssen, J. (2015) A political ecology perspective of land degradation in the North Ethiopian Highlands. Land Degradation and Development, 26, 521-530. Loveland, P., Weeb, J. (2003) Is there a critical level of organic matter in the agricultural soils of temperate regions: a review. Soil & Tillage Research, 70, 1-18. Pereira, P., Brevik, E., Munoz-Rojas, M., Miller, B., Smetanova, A., Depellegrin, D., Misiune, I., Novara, A., Cerda, A. Soil mapping and process modelling for sustainable land management. In: Pereira, P., Brevik, E., Munoz-Rojas, M., Miller, B. (Eds.) Soil mapping and process modelling for sustainable land use management (Elsevier Publishing House) ISBN: 9780128052006

Soil and hydrology sciences need laboratory and field experiments in the classroom. An example from the SEDER (Soil Erosion and Degradation Research Group) from the University of Valencia

NASA Astrophysics Data System (ADS)

Cerdà, Artemi; González Pelayo, Óscar; García Orenes, Fuensanta; Jordán, Antonio; Pereira, Paulo; Novara, Agata; Úbeda, Xavier

2015-04-01

The use of experimental stations and long-term measurements in the field and in the laboratory contributed to large datasets and key information to understand the soil system and the hydrological cycle (Neal et al., 2011; García Orenes et al., 2012; López-Garrido et al., 2012; Kröpf et al., 2013; Nadal-Romero, 2013; Taguas et al., 2013; Zhao et al., 2013). However, teaching in high schools and colleagues require simple experiments to help the students to understand the soil and water resources and management. We show here the experiments and measurements we conduct within the teaching program of the Soil Erosion and Degradation Research Group at the University of Valencia to help the students in the understanding of the soil and hydrologic processes. The expereriments and measurements developed are the following: (i) Water Drop Penetration Time (WDPT) to determine the soil water repellency; (ii) Leaves water retention capacity measured in the field; (iii) soil infiltration capacity measured with simple ring infiltrometers; (iv) measurement of the soil bulk density; and (v) measurement of the soil water content. Those experiments and measurements are applied to agriculture, rangeland and fire affected soils. Acknowledgements To the "Ministerio de Economía and Competitividad" of Spanish Government for finance the POSTFIRE project (CGL2013- 47862-C2-1-R). The research projects GL2008-02879/BTE, LEDDRA 243857 and PREVENTING AND REMEDIATING DEGRADATION OF SOILS IN EUROPE THROUGH LAND CARE (RECARE)FP7-ENV-2013- supported this research. References García-Orenes, F., Roldán, A., Mataix-Solera, J., Cerdà, A., Campoy, M., Arcenegui, V., Caravaca, F. 2012 Soil structural stability and erosion rates influenced by agricultural management practices in a semi-arid Mediterranean agro-ecosystem. Soil Use and Management 28(4): 571-579. DOI: 10.1111/j.1475-2743.2012.00451.x Kröpfl, A. I., Cecchi, G. A., Villasuso, N. M., Distel, R. A. 2013. Degradation and recovery processes in Semi-Arid patchy rangelands of northern Patagonia, Argentina. Land Degradation & Development, 24: 393- 399. DOI 10.1002/ldr.1145 López-Garrido, R., Deurer, M., Madejón, E., Murillo, J. M., Moreno, F. 2012. Tillage influence on biophysical soil properties: The example of a long-term tillage experiment under Mediterranean rainfed conditions in South Spain. Soil and Tillage Research, 118, 52-60. Mekuria, W., Aynekulu, E. 2013. Exclosure land management for restoration of the soils in degrade communal grazing lands in Northern Ethiopia. Land Degradation & Development, 24: 528- 538. DOI 10.1002/ldr.1146 Nadal-Romero, E., Lasanta, T., García-Ruiz, J. M. 2013. Runoff and sediment yield from land under various uses in a Mediterranean mountain area: long-term results from an experimental station. Earth Surface Processes and Landforms, 38(4), 346-355. Neal, C., Reynolds, B., Norris, D., Kirchner, J. W., Neal, M., Rowland, P., Wright, D. 2011. Three decades of water quality measurements from the Upper Severn experimental catchments at Plynlimon, Wales: an openly accessible data resource for research, modelling, environmental management and education. Hydrological Processes, 25(24), 3818-3830. Taguas, E. V., Carpintero, E., and Ayuso, J. L. 2013. Assessing land degradation risk through the long-term analysis of erosivity: a case study in Southern Spain. Land Degradation & Development, 24: 179- 187. DOI 10.1002/ldr.1119 Zhao, G., Mu, X., Wen, Z., Wang, F., and Gao, P. 2013. Soil erosion, conservation, and Eco-environment changes in the Loess Plateau of China. Land Degradation & Development, 24: 499- 510. DOI 10.1002/ldr.2246

Los receptores epidérmicos humanos en el cáncer gástrico: alteraciones moleculares y su papel como diana terapéutica.

PubMed

Bustos-Carpinteyro, Andrea Rebeca; Magaña-Torres, María Teresa; González-García, Juan Ramón; Torres-Jasso, Juan Heriberto; Sánchez-López, Josefina Yoaly

2017-01-01

Gastric cancer (GC) is the third leading cause of cancer death worldwide; both environmental and genetic factors are involved in the etiology of this neoplasia. The human epidermal receptor (HER) pathway is essential for proliferation and differentiation of normal cells; but it is also implicated in the growth of cancer cells. In this work we investigate the molecular alterations in genes that encodes for HER receptors reported in GC, as well the role as therapeutic targets. We reviewed the literature reported to date regarding overexpression of HER-receptors, amplification and somatic mutations in ERBB genes occurred in gastric tumors, as well as the anti-HER therapies tested for treatment of GC. In GC, the overexpression of HER family is reported in a range of 12-87% of cases; up to 67% of cases with amplification, and 90 somatic mutations in ERBB genes. The only drug anti-HER approved for using combined with chemotherapy, in treatment of patients with advanced GC is trastuzumab; however, other targeted therapies are being investigated. The role of the HER family as a therapeutic target has not shown significant improvements in recent years; hence, further studies are required to find better options for treatment of GC. Copyright: © 2017 SecretarÍa de Salud.

Venus - 3D Perspective View of Latona Corona and Dali Chasma

NASA Technical Reports Server (NTRS)

1992-01-01

This computer-generated perspective view of Latona Corona and Dali Chasma on Venus shows Magellan radar data superimposed on topography. The view is from the northeast and vertical exaggeration is 10 times. Exaggeration of relief is a common tool scientists use to detect relationships between structure (i.e. faults and fractures) and topography. Latona Corona, a circular feature approximately 1,000 kilometers (620 miles) in diameter whose eastern half is shown at the left of the image, has a relatively smooth, radar-bright raised rim. Bright lines or fractures within the corona appear to radiate away from its center toward the rim. The rest of the bright fractures in the area are associated with the relatively deep (approximately 3 kilometers or 1.9 miles) troughs of Dali Chasma. The Dali and Diana Chasma system consist of deep troughs that extend for 7,400 kilometers (4,588 miles) and are very distinct features on Venus. Those chasma connect the Ovda and Thetis highlands with the large volcanoes at Atla Regio and thus are considered to be the 'Scorpion Tail' of Aphrodite Terra. The broad, curving scarp resembles some of Earth's subduction zones where crustal plates are pushed over each other. The radar-bright surface at the highest elevation along the scarp is similar to surfaces in other elevated regions where some metallic mineral such as pyrite (fool's gold) may occur on the surface.

Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology

PubMed Central

Busch, Albert; Busch, Martin; Scholz, Claus-Jürgen; Kellersmann, Richard; Otto, Christoph; Chernogubova, Ekaterina; Maegdefessel, Lars; Zernecke, Alma; Lorenz, Udo

2016-01-01

Limited comprehension of aneurysm pathology has led to inconclusive results from clinical trials. miRNAs are key regulators of post-translational gene modification and are useful tools in elucidating key features of aneurysm pathogenesis in distinct entities of abdominal and popliteal aneurysms. Here, surgically harvested specimens from 19 abdominal aortic aneurysm (AAA) and 8 popliteal artery aneurysm (PAA) patients were analyzed for miRNA expression and histologically classified regarding extracellular matrix (ECM) remodeling and inflammation. DIANA-based computational target prediction and pathway enrichment analysis verified our results, as well as previous ones. miRNA-362, -19b-1, -194, -769, -21 and -550 were significantly down-regulated in AAA samples depending on degree of inflammation. Similar or inverse regulation was found for miR-769, 19b-1 and miR-550, -21, whereas miR-194 and -362 were unaltered in PAA. In situ hybridization verified higher expression of miR-550 and -21 in PAA compared to AAA and computational analysis for target genes and pathway enrichment affirmed signal transduction, cell-cell-interaction and cell degradation pathways, in line with previous results. Despite the vague role of miRNAs for potential diagnostic and treatment purposes, the number of candidates from tissue signature studies is increasing. Tissue morphology influences subsequent research, yet comparison of distinct entities of aneurysm disease can unravel core pathways. PMID:26771601

Multiscale Thermo-Mechanical Design and Analysis of High Frequency and High Power Vacuum Electron Devices

NASA Astrophysics Data System (ADS)

Gamzina, Diana

Diana Gamzina March 2016 Mechanical and Aerospace Engineering Multiscale Thermo-Mechanical Design and Analysis of High Frequency and High Power Vacuum Electron Devices Abstract A methodology for performing thermo-mechanical design and analysis of high frequency and high average power vacuum electron devices is presented. This methodology results in a "first-pass" engineering design directly ready for manufacturing. The methodology includes establishment of thermal and mechanical boundary conditions, evaluation of convective film heat transfer coefficients, identification of material options, evaluation of temperature and stress field distributions, assessment of microscale effects on the stress state of the material, and fatigue analysis. The feature size of vacuum electron devices operating in the high frequency regime of 100 GHz to 1 THz is comparable to the microstructure of the materials employed for their fabrication. As a result, the thermo-mechanical performance of a device is affected by the local material microstructure. Such multiscale effects on the stress state are considered in the range of scales from about 10 microns up to a few millimeters. The design and analysis methodology is demonstrated on three separate microwave devices: a 95 GHz 10 kW cw sheet beam klystron, a 263 GHz 50 W long pulse wide-bandwidth sheet beam travelling wave tube, and a 346 GHz 1 W cw backward wave oscillator.

Experimental search for radiative decays of the pentaquark baryon {Theta}{sup +}(1540)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.

2010-07-15

The data on the reactions K{sup +}Xe {sup {yields}}K{sup 0{gamma}}X and K{sup +}Xe {sup {yields}}K{sup +{gamma}}X, obtained with the bubble chamber DIANA, have been analyzed for possible radiative decays of the {Theta}{sup +}(1540) baryon: {Theta}{sup +} {sup {yields}}K{sup 0}p{gamma} and {Theta}{sup +} {sup {yields}}K{sup +}n{gamma}. No signals have been observed, and we derive the upper limits {Gamma}({Theta}{sup +} {sup {yields}}K{sup 0}p{gamma})/{Gamma}({Theta}{sup +} {sup {yields}}K{sup 0}p) < 0.032 and {Gamma}({Theta}{sup +} {sup {yields}}K{sup +}n{gamma})/{Gamma}({Theta}{sup +} {sup {yields}}K{sup +}n{gamma}) < 0.041 which, using our previous measurement of {Gamma}({Theta}{sup +} {sup {yields}}KN) = 0.39 {+-} 0.10 MeV, translate to {Gamma}({Theta}{sup +} {sup {yields}}K{supmore » 0}p{gamma}) < 8 keV and {Gamma}({Theta}{sup +} {sup {yields}}K{sup +}n{gamma}) < 11 keV at 90% confidence level. We have also measured the cross sections of K{sup +}-induced reactions involving emission of a neutral pion: {sigma}(K{sup +}n {sup {yields}}K{sup 0}p{pi}{sup 0}) = 68 {+-} 18 {mu}b and {sigma}(K{sup +}N {sup {yields}}K{sup +}N{pi}{sup 0}) = 30 {+-} 8 {mu}b for incident K{sup +} momentum of 640 MeV.« less

A Real-Time Imaging System for Stereo Atomic Microscopy at SPring-8's BL25SU

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matsushita, Tomohiro; Guo, Fang Zhun; Muro, Takayuki

2007-01-19

We have developed a real-time photoelectron angular distribution (PEAD) and Auger-electron angular distribution (AEAD) imaging system at SPring-8 BL25SU, Japan. In addition, a real-time imaging system for circular dichroism (CD) studies of PEAD/AEAD has been newly developed. Two PEAD images recorded with left- and right-circularly polarized light can be regarded as a stereo image of the atomic arrangement. A two-dimensional display type mirror analyzer (DIANA) has been installed at the beamline, making it possible to record PEAD/AEAD patterns with an acceptance angle of {+-}60 deg. in real-time. The twin-helical undulators at BL25SU enable helicity switching of the circularly polarized lightmore » at 10Hz, 1Hz or 0.1Hz. In order to realize real-time measurements of the CD of the PEAD/AEAD, the CCD camera must be synchronized to the switching frequency. The VME computer that controls the ID is connected to the measurement computer with two BNC cables, and the helicity information is sent using TTL signals. For maximum flexibility, rather than using a hardware shutter synchronizing with the TTL signal we have developed software to synchronize the CCD shutter with the TTL signal. We have succeeded in synchronizing the CCD camera in both the 1Hz and 0.1Hz modes.« less

Differential miRNA expression in B cells is associated with inter-individual differences in humoral immune response to measles vaccination.

PubMed

Haralambieva, Iana H; Kennedy, Richard B; Simon, Whitney L; Goergen, Krista M; Grill, Diane E; Ovsyannikova, Inna G; Poland, Gregory A

2018-01-01

MicroRNAs are important mediators of post-transcriptional regulation of gene expression through RNA degradation and translational repression, and are emerging biomarkers of immune system activation/response after vaccination. We performed Next Generation Sequencing (mRNA-Seq) of intracellular miRNAs in measles virus-stimulated B and CD4+ T cells from high and low antibody responders to measles vaccine. Negative binomial generalized estimating equation (GEE) models were used for miRNA assessment and the DIANA tool was used for gene/target prediction and pathway enrichment analysis. We identified a set of B cell-specific miRNAs (e.g., miR-151a-5p, miR-223, miR-29, miR-15a-5p, miR-199a-3p, miR-103a, and miR-15a/16 cluster) and biological processes/pathways, including regulation of adherens junction proteins, Fc-receptor signaling pathway, phosphatidylinositol-mediated signaling pathway, growth factor signaling pathway/pathways, transcriptional regulation, apoptosis and virus-related processes, significantly associated with neutralizing antibody titers after measles vaccination. No CD4+ T cell-specific miRNA expression differences between high and low antibody responders were found. Our study demonstrates that miRNA expression directly or indirectly influences humoral immunity to measles vaccination and suggests that B cell-specific miRNAs may serve as useful predictive biomarkers of vaccine humoral immune response.

G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis.

PubMed

Giráldez, Servando; Galindo-Moreno, María; Limón-Mortés, M Cristina; Rivas, A Cristina; Herrero-Ruiz, Joaquín; Mora-Santos, Mar; Sáez, Carmen; Japón, Miguel Á; Tortolero, Maria; Romero, Francisco

2017-07-01

Polo-like kinase 1 (PLK1) is a serine/threonine kinase involved in several stages of the cell cycle, including the entry and exit from mitosis, and cytokinesis. Furthermore, it has an essential role in the regulation of DNA replication. Together with cyclin A, PLK1 also promotes CDH1 phosphorylation to trigger its ubiquitination and degradation, allowing cell cycle progression. The PLK1 levels in different type of tumors are very high compared to normal tissues, which is consistent with its role in promoting proliferation. Therefore, several PLK1 inhibitors have been developed and tested for the treatment of cancer. Here, we further analyzed PLK1 degradation and found that cytoplasmic PLK1 is ubiquitinated and subsequently degraded by the SCF βTrCP /proteasome. This procedure is triggered when heat shock protein (HSP) 90 is inhibited with geldanamycin, which results in misfolding of PLK1. We also identified CDK1 as the major kinase involved in this degradation. Our work shows for the first time that HSP90 inhibition arrests cell cycle progression at the G 1 /S transition. This novel mechanism inhibits CDH1 degradation through CDK1-dependent PLK1 destruction by the SCF βTrCP /proteasome. In these conditions, CDH1 substrates do not accumulate and cell cycle arrests, providing a novel pathway for regulation of the cell cycle at the G 1 -to-S boundary.-Giráldez, S., Galindo-Moreno, M., Limón-Mortés, M. C., Rivas, A. C., Herrero-Ruiz, J., Mora-Santos, M., Sáez, C., Japón, M. Á., Tortolero, M., Romero, F. G 1 /S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis. © FASEB.

Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin

PubMed Central

do Carmo, Jussara M.; da Silva, Alexandre A.; Romero, Damian G.; Hall, John E.

2017-01-01

Interactions of hypothalamic signaling pathways that control body temperature (BT), blood pressure (BP), and energy balance are poorly understood. We investigated whether the chronic BP and metabolic actions of leptin are differentially modulated by changes in ambient temperature (TA). Mean arterial pressure (MAP), heart rate (HR), BT, motor activity (MA), and oxygen consumption (Vo2) were measured 24 h/d at normal laboratory TA (23°C), at thermoneutral zone (TNZ, 30°C) for mice or during cold exposure (15°C) in male wild-type mice. After control measurements, leptin (4 μg/kg/min) or saline vehicle was infused for 7 d. At TNZ, leptin reduced food intake (−11.0 ± 0.5 g cumulative deficit) and body weight by 6% but caused no changes in MAP or HR. At 15°C, leptin infusion did not alter food intake but increased MAP and HR (8 ± 1 mmHg and 33 ± 7 bpm), while Vo2 increased by ∼10%. Leptin reduced plasma glucose and insulin levels at 15°C but not at 30°C. These results demonstrate that the chronic anorexic effects of leptin are enhanced at TNZ, while its effects on insulin and glucose levels are attenuated and its effects on BP and HR are abolished. Conversely, cold TA caused resistance to leptin’s anorexic effects but amplified its effects to raise BP and reduce insulin and glucose levels. Thus, the brain circuits by which leptin regulates food intake and cardiovascular function are differentially influenced by changes in TA.—Do Carmo, J. M., da Silva, A. A., Romero, D. G., Hall, J. E. Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin. PMID:28228474

Association of Urinary Activity of MMP-2 with Microalbuminuria in an Isolated Sample of Subjects Living in High Altitude Rural Locations in México.

PubMed

Hernández-Hernández, Magda Elena; Morales-Romero, Jaime; Sampieri, Clara Luz; Luna Lozano, Diego Jesús; Valencia Lezama, Isidra Del Carmen; Muñoz Contreras, Mónica Janett; Rodríguez Hernández, Arturo

2017-09-01

Hernández-Hernández, Magda Elena, Jaime Morales-Romero, Clara Luz Sampieri, Diego Jesús Luna Lozano, Isidra del Carmen Valencia Lezama, Mónica Janett Muñoz Contreras, and Arturo Rodríguez Hernández. Association of urinary activity of MMP-2 with microalbuminuria in an isolated sample of subjects living in high altitude rural locations in México. High Alt Med Biol. 18:209-218, 2017.-Matrix metalloproteinases (MMP) are implicated in remodeling of the renal extracellular matrix. In a cross-sectional study we evaluated renal impairment in general population of high-altitude rural locations in México. Multivariable analysis was performed to identify the association between MMP-2 and MMP-9 and microalbuminuria. Twenty-eight (20.9%) subjects with renal impairment (WRI) and 106 (79.1%) without renal impairment were included. No differences were found relating to sex, location, marital status, current habits, weight, height, body mass index, waist size in males, creatinine in males, and uric acid. In contrast, differences were found among age, level of education, waist size in general and in females, creatinine in general and in females, urinary albumin, urea, glucose, total cholesterol, and triglycerides. Proportions of hypertension, type 2 diabetes mellitus, central abdominal obesity, hypertriglyceridemia, and hypercholesterolemia were greater in the group WRI. Presence of urinary MMP-2 or of both urinary gelatinases and arbitrary unit (AU) values ≥P 90 were associated with microalbuminuria. We conclude that AU values ≥P 90 of urinary MMP-2 (OR = 20.1, p = 0.002) is associated with microalbuminuria.

Description of four new species and a revision of the genus Tripaphylus Richiardi in Anonymous, 1878 (Copepoda: Siphonostomatoida: Sphyriidae).

PubMed

Dippenaar, Susan M

2018-03-01

Tripaphylus Richiardi in Anonymous, 1878 is one of the genera of the Sphyriidae Wilson, 1919 and it currently accommodates ten species. Only scanty descriptions are available for the females and some males of the species. Tripaphylus specimens, described and illustrated in this paper, were collected from elasmobranch hosts off the South African coast or came from the private collection of the late Dr G. Benz. Collected specimens were fixed and preserved in 70% ethanol, examined by light - and scanning electron microscopy, and compared with the known species. Descriptions and illustrations are provided for the transformed adult females and males of T. elongatus (Wilson, 1932) and T. versicolor (Wilson, 1919) while illustrated descriptions of the transformed adult females are also provided for T. ferox (Wilson, 1919) and T. vaissierei (Delamare Deboutteville & Nuñes-Ruivo, 1954). Additionally, the material previously reported as T. ferox is considered to represent T. elongatus and that reported as T. lobatus (Kirtisinghe, 1964) is considered a junior synonym of T. vaissierei. Based on the collected material the transformed adult female and male of T. lewisi n. sp. are described as well as the adult transformed females of T. benzi n. sp., T. hoi n. sp., and T. beatricae n. sp. A summarised review of the main features is provided for each of the previously described T. musteli (van Beneden, 1851), T. hemigalei Kirtisinghe, 1964, T. australis (Kabata, 1993), T. triakis (Castro Romero, 2001) and T. asymboli (Turner, Kyne & Bennett, 2003). Furthermore, reasons are provided for the recommendation that T. hemigalei be considered a species inquirenda. An identification key to the transformed adult females of all species of Tripaphylus is provided and the host records are also updated.

Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin.

PubMed

do Carmo, Jussara M; da Silva, Alexandre A; Romero, Damian G; Hall, John E

2017-06-01

Interactions of hypothalamic signaling pathways that control body temperature (BT), blood pressure (BP), and energy balance are poorly understood. We investigated whether the chronic BP and metabolic actions of leptin are differentially modulated by changes in ambient temperature ( T A ). Mean arterial pressure (MAP), heart rate (HR), BT, motor activity (MA), and oxygen consumption ( V o 2 ) were measured 24 h/d at normal laboratory T A (23°C), at thermoneutral zone (TNZ, 30°C) for mice or during cold exposure (15°C) in male wild-type mice. After control measurements, leptin (4 μg/kg/min) or saline vehicle was infused for 7 d. At TNZ, leptin reduced food intake (-11.0 ± 0.5 g cumulative deficit) and body weight by 6% but caused no changes in MAP or HR. At 15°C, leptin infusion did not alter food intake but increased MAP and HR (8 ± 1 mmHg and 33 ± 7 bpm), while V o 2 increased by ∼10%. Leptin reduced plasma glucose and insulin levels at 15°C but not at 30°C. These results demonstrate that the chronic anorexic effects of leptin are enhanced at TNZ, while its effects on insulin and glucose levels are attenuated and its effects on BP and HR are abolished. Conversely, cold T A caused resistance to leptin's anorexic effects but amplified its effects to raise BP and reduce insulin and glucose levels. Thus, the brain circuits by which leptin regulates food intake and cardiovascular function are differentially influenced by changes in T A -Do Carmo, J. M., da Silva, A. A., Romero, D. G., Hall, J. E. Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin. © FASEB.

Enhanced Frontoparietal Synchronized Activation During the Wake-Sleep Transition in Patients with Primary Insomnia

PubMed Central

Corsi-Cabrera, María; Figueredo-Rodríguez, Pedro; del Río-Portilla, Yolanda; Sánchez-Romero, Jorge; Galán, Lídice; Bosch-Bayard, Jorge

2012-01-01

Introduction: Cognitive and brain hyperactivation have been associated with trouble falling asleep and sleep misperception in patients with primary insomnia (PI). Activation and synchronization/temporal coupling in frontal and frontoparietal regions involved in executive control and endogenous attention might be implicated in these symptoms. Methods: Standard polysomnography (PSG) and electroencephalogram (EEG) were recorded in 10 unmedicated young patients (age 19-34 yr) with PI with no other sleep/medical condition, and in 10 matched control subjects. Absolute power, temporal coupling, and topographic source distribution (variable resolution electromagnetic tomography or VARETA) were obtained for all time spent in waking, Stage 1 and Stage 2 of the wake-sleep transition period (WSTP), and the first 3 consecutive min of N3. Subjective sleep quality and continuity were evaluated. Results: In comparison with control subjects, patients with PI exhibited significantly higher frontal beta power and current density, and beta and gamma frontoparietal temporal coupling during waking and Stage 1. Conclusion: These findings suggest that frontal deactivation and disengagement of brain regions involved in executive control, attention, and self-awareness are impaired in patients with PI. The persistence of this activated and coherent network during the wake-sleep transition period (WSTP) may contribute to a better understanding of underlying mechanisms involved in difficulty in falling asleep, in sleep misperception, and in the lighter, poorer, and nonrefreshing sleep experienced by some patients with PI. Citation: Corsi-Cabrera M; Figueredo-Roríguez P; del Río-Portilla Y; Sánchez-Romero J; Galán L; Bosch-Bayard J. Enhanced frontoparietal synchronized activation during the wake-sleep transition in patients with primary insomnia. SLEEP 2012;35(4):501-511. PMID:22467988

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

PubMed Central

Figueroa-Romero, Claudia; Iñiguez-Lluhí, Jorge A.; Stadler, Julia; Chang, Chuang-Rung; Arnoult, Damien; Keller, Peter J.; Hong, Yu; Blackstone, Craig; Feldman, Eva L.

2009-01-01

Dynamin-related protein (Drp) 1 is a key regulator of mitochondrial fission and is composed of GTP-binding, Middle, insert B, and C-terminal GTPase effector (GED) domains. Drp1 associates with mitochondrial fission sites and promotes membrane constriction through its intrinsic GTPase activity. The mechanisms that regulate Drp1 activity remain poorly understood but are likely to involve reversible post-translational modifications, such as conjugation of small ubiquitin-like modifier (SUMO) proteins. Through a detailed analysis, we find that Drp1 interacts with the SUMO-conjugating enzyme Ubc9 via multiple regions and demonstrate that Drp1 is a direct target of SUMO modification by all three SUMO isoforms. While Drp1 does not harbor consensus SUMOylation sequences, our analysis identified2 clusters of lysine residues within the B domain that serve as noncanonical conjugation sites. Although initial analysis indicates that mitochondrial recruitment of ectopically expressed Drp1 in response to staurosporine is unaffected by loss of SUMOylation, we find that Drp1 SUMOylation is enhanced in the context of the K38A mutation. This dominant-negative mutant, which is deficient in GTP binding and hydrolysis, does not associate with mitochondria and prevents normal mitochondrial fission. This finding suggests that SUMOylation of Drp1 is linked to its activity cycle and is influenced by Drp1 localization.—Figueroa-Romero, C., Iñiguez-Lluhí, J. A., Stadler, J., Chang, C.-R., Arnoult, D., Keller, P. J., Hong, Y., Blackstone, C., Feldman, E. L. SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. PMID:19638400

Investigating the effect of fire dynamics on aboveground carbon storage in the Bateke landscape, Republic of Congo

NASA Astrophysics Data System (ADS)

Nieto Quintano, P.; Mitchard, E. T.; Ryan, C.; Tim, R.

2016-12-01

It is estimated that 68% of Africa's surface area burns every year (Roy et al. 2008), being the savanna biome the most continuously affected by burning with strong environmental and social impacts (Romero-Ruiz et al., 2010). Most fires in Africa are anthropogenic and occur during the Late Dry Season, but their dynamics and effects remain understudied. Sankaran et al. (2005) suggested that if disturbances by fire, browsers and humans were absent, then large areas of Africa would become forests. The main objective of this research is to understand the woody cover, productivity, carbon storage and fire regime of the complex forest/savanna system of the Bateke Plateau. The Bateke Plateau is a landscape composed of frequently burned grassland savanna surrounded by tropical forest, situated in the centre of the Republic of Congo. This study combines two approaches: firstly experimental, with long term field experiments where the fire regime is manipulated, and then observational, using remote sensing to study the past history of fire regime in the region. Field experiments suggest that late dry season fires are more intense and have higher mortality rates. We also investigated aboveground biomass, fire occurrence and intensity, using Landsat, ALOS PALSAR and the fire products of MODIS. We found that most savanna areas burnt at least once every 4 years, with more frequent fires occurring in the late dry season and around roads and settlements. This two approaches will be then combined to create a novel model of vegetation-fire-climate interactions in order to predict the vegetation response to different future scenarios. The results will be used to promote better management of this area to enhance carbon storage, as well as increase our understanding of vegetation dynamics in this understudied ecosystem and help orient policy and conservation.

Fate of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches under different storage conditions.

PubMed

Alegre, Isabel; Abadias, Maribel; Anguera, Marina; Usall, Josep; Viñas, Inmaculada

2010-10-01

Consumption of fresh-cut produce has sharply increased recently causing an increase of foodborne illnesses associated with these products. As generally, acidic fruits are considered 'safe' from a microbiological point of view, the aim of this work was to study the growth and survival of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches. The three foodborne pathogens population increased more than 2 log(10)units on fresh-cut peach when stored at 20 and 25 degrees C after 48 h. At 10 degrees C only L. innocua grew more than 1 log(10)unit and it was the only pathogen able to grow at 5 degrees C. Differences in growth occurred between different peach varieties tested, with higher population increases in those varieties with higher pH ('Royal Glory' 4.73+/-0.25 and 'Diana' 4.12+/-0.18). The use of common strategies on extending shelf life of fresh-cut produce, as modified atmosphere packaging and the use of the antioxidant substance, ascorbic acid (2%w/v), did not affect pathogens' growth at any of the temperatures tested (5 and 25 degrees C). Minimally-processed peaches have shown to be a good substrate for foodborne pathogens' growth regardless use of modified atmosphere and ascorbic acid. Therefore, maintaining cold chain and avoiding contamination is highly necessary. 2010 Elsevier Ltd. All rights reserved.

Adherence to WCRF/AICR cancer prevention recommendations and metabolic syndrome in breast cancer patients.

PubMed

Bruno, Eleonora; Gargano, Giuliana; Villarini, Anna; Traina, Adele; Johansson, Harriet; Mano, Maria Piera; Santucci De Magistris, Maria; Simeoni, Milena; Consolaro, Elena; Mercandino, Angelica; Barbero, Maggiorino; Galasso, Rocco; Bassi, Maria Chiara; Zarcone, Maurizio; Zagallo, Emanuela; Venturelli, Elisabetta; Bellegotti, Manuela; Berrino, Franco; Pasanisi, Patrizia

2016-01-01

Metabolic syndrome (MetS), conventionally defined by the presence of at least three out of five dismetabolic traits (abdominal obesity, hypertension, low plasma HDL-cholesterol and high plasma glucose and triglycerides), has been associated with both breast cancer (BC) incidence and prognosis. We investigated the association between the prevalence of MetS and a score of adherence to the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) recommendations for the prevention of cancer in a cross-sectional study of BC patients. The DIet and ANdrogen-5 study (DIANA-5) for the prevention of BC recurrences recruited 2092 early stage BC survivors aged 35-70. At recruitment, all women completed a 24-hour food frequency and physical activity diary on their consumption and activity of the previous day. Using these diaries we created a score of adherence to five relevant WCRF/AICR recommendations. The prevalence ratios (PRs) and 95% confidence intervals (CIs) of MetS associated with the number of recommendations met were estimated using a binomial regression model. The adjusted PRs of MetS decreased with increasing number of recommendations met (p < 0.001). Meeting all the five recommendations versus meeting none or only one was significantly associated with a 57% lower MetS prevalence (95% CI 0.35-0.73). Our results suggest that adherence to WCRF/AICR recommendations is a major determinant of MetS and may have a clinical impact. © 2015 UICC.

In Situ Boundary Layer Coral Metabolism in the Atlantic Ocean Acidification Test Bed

NASA Astrophysics Data System (ADS)

McGillis, Wade

2013-04-01

and Chris Langdon, Brice Loose, Dwight Gledhill, Diana Hsueh, Derek Manzello, Ian Enochs, Ryan Moyer We present net ecosystem productivity (nep) and net ecosystem calcification (nec) in coral and seagrass ecosystems using the boundary layer gradient flux technique (CROSS). Coastal anthropogenic inputs and changes in global ocean chemistry in response to rising levels of atmospheric carbon dioxide has emerged in recent years as a topic of considerable concern. Coral reefs are particularly vulnerable from eroded environmental conditions including ocean acidification and water pollution. The Atlantic Ocean Acidification Testbed (AOAT) project monitors metabolism to ascertain the continuing health of coral reef ecosystems. The CROSS boundary layer nep/nec approach is one component of this diagnostic program. Certification of CROSS as an operational monitoring tool is underway in the AOAT. CROSS inspects a benthic community and measures productivity/respiration and calcification/dissolution over an area of 10 square meters. Being a boundary layer tool, advection and complex mesoscale flows are not a factor or concern and CROSS is autonomous and can be used at deep benthic sites. The interrogation area is not enclosed therefore exposed to ambient light, flow, and nutrient levels. CROSS is easy to deploy, unambiguous, and affordable. Repeated measurements have been made from 2011-2012 in reefal systems in La Parguera Puerto Rico and the Florida Keys, USA. Diurnal, seasonal and regional metabolism will be compared and discussed. The ability to accurately probe benthic ecosystems provides a powerful management and research tool to policy makers and researchers.

Pharmaceuticals, alkylphenols and pesticides in Mediterranean coastal waters: Results from a pilot survey using passive samplers

NASA Astrophysics Data System (ADS)

Munaron, Dominique; Tapie, Nathalie; Budzinski, Hélène; Andral, Bruno; Gonzalez, Jean-Louis

2012-12-01

21 pharmaceuticals, 6 alkylphenols and 27 hydrophilic pesticides and biocides were investigated using polar organic contaminant integrative samplers (POCIS) during a large-scale study of contamination of French Mediterranean coastal waters. Marine and transitional water-bodies, defined under the EU Water Framework Directive were monitored. Our results show that the French Mediterranean coastal waters were contaminated with a large range of emerging contaminants, detected at low concentrations during the summer season. Caffeine, carbamazepine, theophilline and terbutaline were detected with a detection frequency higher than 83% in the coastal waters sampled, 4-nonylphenol (4-NP), 4-tert-octylphenol (4-OP) and 4-nonylphenol diethoxylate (NP2EO) were detected in all coastal waters sampled, and diuron, terbuthylazine, atrazine, irgarol and simazine were detected in more than 77% of samples. For pharmaceuticals, highest time-weighted average (TWA) concentrations were measured for caffeine and carbamazepine (32 and 12 ng L-1, respectively). For alkylphenols, highest TWA concentrations were measured for 4-nonylphenol mono-ethoxylate and 4-nonylphenol (41 and 33 ng L-1, respectively), and for herbicides and biocides, they were measured for diuron and irgarol (33 and 2.5 ng L-1, respectively). Except for Diana lagoon, lagoons and semi-enclosed bays were the most contaminated areas for herbicides and pharmaceuticals, whilst, for alkylphenols, levels of contamination were similar in lagoons and coastal waters. This study demonstrates the relevance and utility of POCIS as quantitative tool for measuring low concentrations of emerging contaminants in marine waters.

[Delphi consensus on management of dyslipidaemia in patients with impaired glucose metabolism: Diana study].

PubMed

Pedro-Botet, Juan; Barrios, Vivencio; Pascual, Vicente; Ascaso, Juan F; Cases, Aleix; Millán, Jesús; Serrano, Adalberto; Pintó, Xavier

2016-01-01

The aim of the present study was to develop a multidisciplinary consensus based on the Delphi system to establish clinical recommendations for the management of dyslipidaemia when hyperglycaemia is present, and the relevant factors that should be taken into consideration when prescribing and monitoring treatment with statins. The questionnaire developed by the scientific committee included four blocks of questions about dyslipidaemia in patients with impaired glucose metabolism. The results of the first two blocks are presented here: a) management of dyslipidaemia; b) relevant factors that should be taken into consideration when prescribing and monitoring treatment with statins. Among the 497 experts who participated in the study, an agreement of over 90% was attained for recommending screening for dyslipidaemia in patients with diabetes or pre-diabetes and/or cardiovascular disease or a family history and/or abdominal obesity and/or hypertension. There was a high degree of agreement that a statin is the lipid-lowering treatment of choice, and that it should be switched when side effects develop. Also, the choice of statin and dose should be made according to baseline LDL cholesterol levels, the target to achieve, and the possible drug-drug interactions. The screening of dyslipidaemia is primarily conducted in patients with cardiovascular disease, or any major cardiovascular risk factor. When prescribing a statin, physicians mainly focus on the ability to reduce LDL cholesterol and the risk of drug interactions. Copyright © 2016 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

ERP correlates of source memory: unitized source information increases familiarity-based retrieval.

PubMed

Diana, Rachel A; Van den Boom, Wijnand; Yonelinas, Andrew P; Ranganath, Charan

2011-01-07

Source memory tests typically require subjects to make decisions about the context in which an item was encoded and are thought to depend on recollection of details from the study episode. Although it is generally believed that familiarity does not contribute to source memory, recent behavioral studies have suggested that familiarity may also support source recognition when item and source information are integrated, or "unitized," during study (Diana, Yonelinas, and Ranganath, 2008). However, an alternative explanation of these behavioral findings is that unitization affects the manner in which recollection contributes to performance, rather than increasing familiarity-based source memory. To discriminate between these possibilities, we conducted an event-related potential (ERP) study testing the hypothesis that unitization increases the contribution of familiarity to source recognition. Participants studied associations between words and background colors using tasks that either encouraged or discouraged unitization. ERPs were recorded during a source memory test for background color. The results revealed two distinct neural correlates of source recognition: a frontally distributed positivity that was associated with familiarity-based source memory in the high-unitization condition only and a parietally distributed positivity that was associated with recollection-based source memory in both the high- and low-unitization conditions. The ERP and behavioral findings provide converging evidence for the idea that familiarity can contribute to source recognition, particularly when source information is encoded as an item detail. Copyright © 2010 Elsevier B.V. All rights reserved.

Differential miRNA expression in B cells is associated with inter-individual differences in humoral immune response to measles vaccination

PubMed Central

Haralambieva, Iana H.; Kennedy, Richard B.; Simon, Whitney L.; Goergen, Krista M.; Grill, Diane E.; Ovsyannikova, Inna G.

2018-01-01

Background MicroRNAs are important mediators of post-transcriptional regulation of gene expression through RNA degradation and translational repression, and are emerging biomarkers of immune system activation/response after vaccination. Methods We performed Next Generation Sequencing (mRNA-Seq) of intracellular miRNAs in measles virus-stimulated B and CD4+ T cells from high and low antibody responders to measles vaccine. Negative binomial generalized estimating equation (GEE) models were used for miRNA assessment and the DIANA tool was used for gene/target prediction and pathway enrichment analysis. Results We identified a set of B cell-specific miRNAs (e.g., miR-151a-5p, miR-223, miR-29, miR-15a-5p, miR-199a-3p, miR-103a, and miR-15a/16 cluster) and biological processes/pathways, including regulation of adherens junction proteins, Fc-receptor signaling pathway, phosphatidylinositol-mediated signaling pathway, growth factor signaling pathway/pathways, transcriptional regulation, apoptosis and virus-related processes, significantly associated with neutralizing antibody titers after measles vaccination. No CD4+ T cell-specific miRNA expression differences between high and low antibody responders were found. Conclusion Our study demonstrates that miRNA expression directly or indirectly influences humoral immunity to measles vaccination and suggests that B cell-specific miRNAs may serve as useful predictive biomarkers of vaccine humoral immune response. PMID:29381765

Research Center Renaming Will Honor Senator Domenici

NASA Astrophysics Data System (ADS)

2008-05-01

New Mexico Tech and the National Radio Astronomy Observatory (NRAO) will rename the observatory's research center on the New Mexico Tech campus to honor retiring U.S. Senator Pete V. Domenici in a ceremony on May 30. The building that serves as the scientific, technical, and administrative center for the Very Large Array (VLA) and Very Long Baseline Array (VLBA) radio telescopes will be named the "Pete V. Domenici Science Operations Center." The building previously was known simply as the "Array Operations Center." Sen. Pete V. Domenici Sen. Pete V. Domenici "The new name recognizes the strong and effective support for science that has been a hallmark of Senator Domenici's long career in public service," said Dr. Fred Lo, NRAO Director. New Mexico Tech President Daniel H. Lopez said Sen. Domenici has always been a supporter of science and research in Socorro and throughout the state. "He's been a statesman for New Mexico, the nation -- and without exaggeration -- for the world," Lopez said. "Anyone with that track record deserves this recognition." Van Romero, Tech vice president of research and economic development, has served as the university's main lobbyist in Washington, D.C., for more than a decade. He said Sen. Domenici has always been receptive to new ideas and willing to take risks. "Over the years, Sen. Domenici has always had time to listen to our needs and goals," Romero said. "He has served as a champion of New Mexico Tech's causes and we owe him a debt of gratitude for all his efforts over the decades." Originally dedicated in 1988, the center houses offices and laboratories that support VLA and VLBA operations. The center also supports work on the VLA modernization project and on the international Atacama Large Millimeter/submillimeter Array (ALMA) project. Work on ALMA at the Socorro center and at the ALMA Test Facility at the VLA site west of Socorro has focused on developing and testing equipment to be deployed at the ALMA site in Chile's Atacama Desert. The research facility, part of the National Science Foundation-funded NRAO, was located on the NM Tech campus through a joint Federal-State effort spearheaded by Domenici. "Senator Domenici has worked hard over the years to support research both at New Mexico Tech and at the NRAO, and our facility on the New Mexico Tech campus is a symbol of that support. It's highly appropriate to name it after him," said Dr. Ethan Schreier, President of Associated Universities Inc., which operates the NRAO for the National Science Foundation. Senator Domenici helped make New Mexico Tech's Magdalena Ridge Observatory (MRO) a reality and provided essential support for NRAO's VLA and VLBA. MRO is one of the world's most technologically-advanced optical observatories. The VLA is the most scientifically-productive ground-based telescope in the history of astronomy. "Both these facilities will advance the frontiers of 21st-Century astrophysics, and keep our state and its research community in the forefront of science worldwide," said Dr. Robert Dickman, NRAO's Director for New Mexico Operations. Domenici also was instrumental in bringing the International Law Enforcement Academy -- another New Mexico Tech division -- to Roswell. During the Reagan Administration, Domenici sponsored the legislation that allowed the university to use the "M" Mountain range for research and testing. Lopez said the U.S. Department of the Interior would not let the university conduct testing on the range. A high level bureaucrat told Laurence Lattman, then the president of Tech, that it "would take an act of Congress" for Tech to have unlimited access to the land. Domenici sponsored the legislation -- signed by Reagan -- that gave Tech access to the land. Over the years, Domenici's support has helped Tech launch the homeland security training program in Playas, the EarthScope research and other anti-terrorism training programs. "All these projects benefit New Mexico Tech," Lopez said. "But these programs also benefit the nation. Senator Domenici has always been careful to make sure that federal money went to programs that benefit the entire nation." The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

Soil organic carbon stocks quantification in Mediterranean natural areas, a trade-off between entire soil profiles and soil control sections

NASA Astrophysics Data System (ADS)

Parras-Alcántara, Luis; Lozano-García, Beatriz; Brevik, Eric. C.; Cerdá, Artemi

2015-04-01

Soil organic carbon (SOC) is extremely important in the global carbon (C) cycle; also, SOC is a soil property subject to changes, inasmuch as SOC is highly variable in space and time. The scientific community is researching the fate of the organic carbon in the ecosystems and this is why there is a blooming interest on this topic (Oliveira et al., 2014; Kukal et al., 2015). Soil organic matter play a key role in the Soil System (Fernández-Romero et al., 2014; Parras-Alcántara and Lozano García, 2014; Lozano-García and Parras-Alcántara; Parras-Alcántara et al., 2015).Globally it is known that soil C sequestration is a strategy to mitigate climate change. Over time, some researchers have analyzed entire soil profiles (ESP) by pedogenetic horizons and other researchers have analyzed soil control sections (SCS) (edaphic controls to different thickness), and in each case the benefits of the methodology established was justified. However, very few studies compare both methods (ESP versus SCS). This research sought to analyze the SOC stock (SOCS) variability using both methods (ESP and SCS) in The Despeñaperros Natural Park, a nature reserve that consists of a 76.8 km2 forested area in southern Spain. The park is in a Mediterranean environment and is a natural area (free of human disturbance). Thirty-four sampling points were selected in the study zone. Each sampling point was analyzed in two different ways, as ESP (by horizons) and as SCS with different depth increments (0-25, 25-50, 50-75 and 75-100 cm). The major goal of this research was to study the SOCS variability at regional scale. The studied soils were classified as Phaeozems, Cambisols, Regosols and Leptosols. The total SOCS in the Despeñaperros Natural Park was over 28.2% greater when SCS were used compared to ESP, ranging from 0.8144 Tg C to 0.6353 Tg C respectively (1 Tg = 10E12 g). However, when the top soil (surface horizon and superficial section control) was analyzed, this difference increased to 59.8% in SCS compared to ESP. This research is a preliminary assessment for modeling SOCS at the regional level in Mediterranean natural areas. References Fernández-Romero, M.L., Lozano-García, B., Parras-Alcántara, L., Collins, C.D., and Clark, J.M.: Effects of land management on different forms of soil carbon in olive groves in mediterranean areas, Land Degrad. Develop., in press, available online: in Wiley Online Library (wileyonlinelibrary.com), doi:10.1002/ldr.2327, 2014. Kukal, S.S., Saha, D., Sharma, P., and Sharma, B.D.: Profile distribution of carbon fractions under long-term rice-wheat and maize-wheat production in Alfisol and inceptisols of northwest India, Land Degrad. Develop., in press, available online: in Wiley Online Library (wileyonlinelibrary.com), doi:10.1002/ldr.2299, 2015. Lozano-García, B., and Parras-Alcántara, L.: Variation in soil organic carbon and nitrogen stocks along a toposequence in a traditional mediterranean olive grove, Land Degrad. Develop., 25, 297-304 (2014). http://dx.doi.org/10.1002/ldr.2284 Oliveira, S.P., Lacerda, N.B., Blum, S.C., Escobar, M.E.O., and Oliveira, T.S.: Organic carbon and nitrogen stocks in soils of northeastern Brazil converted to irrigated agriculture, Land Degrad. Develop., in press, available online: in Wiley Online Library (wileyonlinelibrary.com), doi:10.1002/ldr.2264, 2014. Parras-Alcántara, L., and Lozano-García, B.: Conventional tillage versus organic farming in relation to soil organic carbon stock in olive groves in Mediterranean rangelands (southern Spain). Solid Earth, 5, 299-311 (2014). http://dx.doi.org/10.5194/se-5-299-2014. Parras-Alcántara, L., Díaz-Jaimes, L., and Lozano-García, B.: Management effects on soil organic carbon stock in Mediterranean open rangelands -- treeless grasslands, Land Degrad. Develop., in press, available online: in Wiley Online Library (wileyonlinelibrary.com), http://dx.doi.org/10.1002/ldr.2269, 2015.

The real new economy.

PubMed

Farrell, Diana

2003-10-01

During the soar-and-swoon days of the late 1990s, many people believed that information technology, and the Internet in particular, were "changing everything" in business. A fundamental change did happen in the 1990s, but it was less about technology than about competition. Under director Diana Farrell, the McKinsey Global Institute has conducted an extensive study of productivity and its connection to corporate IT spending and use during that period. The study revealed that information technology is important--but not central--to the fate of industries and individual companies. So if information technology was not the primary factor in the productivity surge, what was? The study points to competition and innovation. In those industries that saw increases in competitive intensity, managers were forced to innovate aggressively to protect their revenues and profits. Those innovations--in products, business practices, and technology--led to the gains in productivity. In fact, a critical dynamic of the new economy--the real new economy--is the virtuous cycle of competition, innovation, and productivity growth. Managers can innovate in many ways, but during the 1990s, information technology was a particularly powerful tool, for three reasons: First, IT enabled the development of attractive new products and efficient new business processes. Second, it facilitated the rapid industrywide diffusion of innovations. And third, it exhibited strong scale economies--its benefits multiplied rapidly as its use expanded. This article reveals surprising data on how various industries in the United States and Europe were affected by competition, innovation, and information technology in the 1990s and offers insights about how managers can get more from their IT investments.

Common features of microRNA target prediction tools

PubMed Central

Peterson, Sarah M.; Thompson, Jeffrey A.; Ufkin, Melanie L.; Sathyanarayana, Pradeep; Liaw, Lucy; Congdon, Clare Bates

2014-01-01

The human genome encodes for over 1800 microRNAs (miRNAs), which are short non-coding RNA molecules that function to regulate gene expression post-transcriptionally. Due to the potential for one miRNA to target multiple gene transcripts, miRNAs are recognized as a major mechanism to regulate gene expression and mRNA translation. Computational prediction of miRNA targets is a critical initial step in identifying miRNA:mRNA target interactions for experimental validation. The available tools for miRNA target prediction encompass a range of different computational approaches, from the modeling of physical interactions to the incorporation of machine learning. This review provides an overview of the major computational approaches to miRNA target prediction. Our discussion highlights three tools for their ease of use, reliance on relatively updated versions of miRBase, and range of capabilities, and these are DIANA-microT-CDS, miRanda-mirSVR, and TargetScan. In comparison across all miRNA target prediction tools, four main aspects of the miRNA:mRNA target interaction emerge as common features on which most target prediction is based: seed match, conservation, free energy, and site accessibility. This review explains these features and identifies how they are incorporated into currently available target prediction tools. MiRNA target prediction is a dynamic field with increasing attention on development of new analysis tools. This review attempts to provide a comprehensive assessment of these tools in a manner that is accessible across disciplines. Understanding the basis of these prediction methodologies will aid in user selection of the appropriate tools and interpretation of the tool output. PMID:24600468

Common features of microRNA target prediction tools.

PubMed

Peterson, Sarah M; Thompson, Jeffrey A; Ufkin, Melanie L; Sathyanarayana, Pradeep; Liaw, Lucy; Congdon, Clare Bates

2014-01-01

The human genome encodes for over 1800 microRNAs (miRNAs), which are short non-coding RNA molecules that function to regulate gene expression post-transcriptionally. Due to the potential for one miRNA to target multiple gene transcripts, miRNAs are recognized as a major mechanism to regulate gene expression and mRNA translation. Computational prediction of miRNA targets is a critical initial step in identifying miRNA:mRNA target interactions for experimental validation. The available tools for miRNA target prediction encompass a range of different computational approaches, from the modeling of physical interactions to the incorporation of machine learning. This review provides an overview of the major computational approaches to miRNA target prediction. Our discussion highlights three tools for their ease of use, reliance on relatively updated versions of miRBase, and range of capabilities, and these are DIANA-microT-CDS, miRanda-mirSVR, and TargetScan. In comparison across all miRNA target prediction tools, four main aspects of the miRNA:mRNA target interaction emerge as common features on which most target prediction is based: seed match, conservation, free energy, and site accessibility. This review explains these features and identifies how they are incorporated into currently available target prediction tools. MiRNA target prediction is a dynamic field with increasing attention on development of new analysis tools. This review attempts to provide a comprehensive assessment of these tools in a manner that is accessible across disciplines. Understanding the basis of these prediction methodologies will aid in user selection of the appropriate tools and interpretation of the tool output.

Lack of Evidence of Simian Immunodeficiency Virus Infection Among Nonhuman Primates in Taï National Park, Côte d’Ivoire: Limitations of Noninvasive Methods and SIV Diagnostic Tools for Studies of Primate Retroviruses

PubMed Central

Roeder, Amy D.; Bruford, Michael W.; Noë, Ronald; Delaporte, Eric; Peeters, Martine

2013-01-01

It is now well established that the human immunodeficiency viruses, HIV-1 and HIV-2, are the results of cross-species transmissions of simian immunodeficiency viruses (SIV) naturally infecting nonhuman primates in sub-Saharan Africa. SIVs are found in many African primates, and humans continue to be exposed to these viruses by hunting and handling primate bushmeat. Sooty mangabeys (Cercocebus atys) and western red colobus (Piliocolobus badius badius) are infected with SIV at a high rate in the Taï Forest, Côte d’Ivoire. We investigated the SIV infection and prevalence in 6 other monkey species living in the Taï Forest using noninvasive methods. We collected 127 fecal samples from 2 colobus species (Colobus polykomos and Procolobus verus) and 4 guenon species (C. diana, C. campbelli, C. petaurista, and C. nictitans). We tested these samples for HIV cross-reactive antibodies and performed reverse transcriptase-polymerase chain reactions (RT-PCR) targeting the gag, pol, and env regions of the SIV genome. We screened 16 human microsatellites for use in individual discrimination and identified 4–6 informative markers per species. Serological analysis of 112 samples yielded negative (n=86) or uninterpretable (n=26) results. PCR analysis on 74 samples confirmed the negative results. These results may reflect either the limited number of individuals sampled or a low prevalence of infection. Further research is needed to improve the sensitivity of noninvasive methods for SIV detection. PMID:23950618

Marine exotic isopods from the Iberian Peninsula and nearby waters.

PubMed

Martínez-Laiz, Gemma; Ros, Macarena; Guerra-García, José M

2018-01-01

Effective management of marine bioinvasions starts with prevention, communication among the scientific community and comprehensive updated data on the distribution ranges of exotic species. Despite being a hotspot for introduction due to numerous shipping routes converging at the Strait of Gibraltar, knowledge of marine exotics in the Iberian Peninsula is scarce, especially of abundant but small-sized and taxonomically challenging taxa such as the Order Isopoda. To fill this gap, we conducted several sampling surveys in 44 marinas and provide the first comprehensive study of marine exotic isopods from the Iberian Peninsula, the southern side of the Strait of Gibraltar (northern Africa) and the Balearic Islands. Exotic species included Ianiropsis serricaudis (first record for the Iberian Peninsula and Lusitanian marine province), Paracerceis sculpta (first record for the Alboran Sea ecoregion), Paradella dianae , Paranthura japonica (earliest record for the Iberian Peninsula) and Sphaeroma walkeri . Photographs with morphological details for identification for non-taxonomic experts are provided, their worldwide distribution is updated and patterns of invasion are discussed. We report an expansion in the distribution range of all species, especially at the Strait of Gibraltar and nearby areas. Ianiropsis serricaudis and Paranthura japonica are polyvectic, with shellfish trade and recreational boating being most probable vectors for their introduction and secondary spread. The subsequent finding of the studied species in additional marinas over the years points at recreational boating as a vector and indicates a future spread. We call for attention to reduce lags in the detection and reporting of small-size exotics, which usually remain overlooked or underestimated until the invasion process is at an advanced stage.

TGFbeta and miRNA regulation in familial and sporadic breast cancer

PubMed Central

Pinto, Rosamaria; Pilato, Brunella; Palumbo, Orazio; Carella, Massimo; Popescu, Ondina; Digennaro, Maria; Lacalamita, Rosanna; Tommasi, Stefania

2017-01-01

The term ‘BRCAness’ was introduced to identify sporadic malignant tumors sharing characteristics similar to those germline BRCA-related. Among all mechanisms attributable to BRCA1 expression silencing, a major role has been assigned to microRNAs. MicroRNAs role in familial and sporadic breast cancer has been explored but few data are available about microRNAs involvement in homologous recombination repair control in these breast cancer subgroups. Our aim was to seek microRNAs associated to pathways underlying DNA repair dysfunction in breast cancer according to a family history of the disease. Affymetrix GeneChip microRNA Arrays were used to perform microRNA expression analysis in familial and sporadic breast cancer. Pathway enrichment analysis and microRNA target prediction was carried out using DIANA miRPath v.3 web-based computational tool and miRWalk v.2 database. We analyzed an external gene expression dataset (E-GEOD-49481), including both familial and sporadic breast cancers. For microRNA validation, an independent set of 19 familial and 10 sporadic breast cancers was used. Microarray analysis identified a signature of 28 deregulated miRNAs. For our validation analyses by real time PCR, we focused on miR-92a-1*, miR-1184 and miR-943 because associated to TGF-β signalling pathway, ATM and BRCA1 genes expression. Our results highlighted alterations in miR-92a-1*, miR-1184 and miR-943 expression levels suggesting their involvement in repair of DNA double-strand breaks through TGF-beta pathway control. PMID:28881597

Further evidence for formation of a narrow baryon resonance with positive strangeness in K{sup +} collisions with Xe nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.

2007-01-15

We have continued our investigation of the charge-exchange reaction K{sup +}Xe {sup {yields}} K{sup 0}pXe' in the bubble chamber DIANA. In agreement with our previous results based on part of the present statistics, formation of a narrow pK{sup 0} resonance with mass of 1537 {+-} 2 MeV/c{sup 2} is observed in the elementary transition K{sup +}n {sup {yields}} K{sup 0}p on a neutron bound in the xenon nucleus. The visible width of the peak is consistent with being entirely due to instrumental resolution and allows one to place an upper limit on its intrinsic width: {gamma} < 9 MeV/c{sup 2}.more » A more precise estimate of the resonance intrinsic width, {gamma} = 0.36 {+-} 0.11 MeV/c{sup 2}, is obtained from the ratio between the numbers of resonant and nonresonant charge-exchange events. The signal is observed in a restricted interval of incident K{sup +} momentum that is consistent with smearing of a narrow pK{sup 0} resonance by Fermi motion of the target neutron. The statistical significance of the signal is some 7.3, 5.3, and 4.3 standard deviations for the estimators S/{radical}B,S/{radical}(S+B) and S/{radical}(S+2B), respectively. This observation confirms and reinforces our earlier results, and offers strong evidence for formation of a pentaquark baryon with positive strangeness in the charge-exchange reaction K{sup +}n {sup {yields}} K{sup 0}p on a bound neutron.« less

To Boldly Go: America's Next Era in Space. Sustaining Life on the Earth

NASA Technical Reports Server (NTRS)

2004-01-01

Dr. France Cordova, NASA's Chief Scientist, opened this, the sixth seminar in the Administrator's Seminar Series, by introducing NASA Administrator Daniel S. Goldin. Mr Goldin welcomed the attendees and set the stage for Dr. Cordova's introduction of the first speaker, Dr. Robert Kates of Brown University. Dr. Kates primary concerns are global environmental changes, world hunger, and the size of the population. Human changes, he said, rival the changes of nature. Changes in the size of world population affect the need for more agricultural products, therefore more land for growing food, which leads to deforestation, which affects rainfall, and therefore the water supply which is in increased demand. Human ingenuity can reduce some shortages but generally doesn't keep up with increased demand for life-sustaining essentials. These problems require the concern of intergovernmental organizations, treaties and activities, as well as transnational corporations, and non-governmental and private, volunteer organizations. Next Dr. Diana Liverman of Pennsylvania State University spoke on human interactions regarding climate and society. She considered the effect of changes in land use on climate, using Mexico as an example. Mexicans changed from raising much wheat to raising more fruits and vegetables. This was in response to the demands of the market. The results were more industry, population growth, greater income, drought (because the new crops required more water), and conflicts over water supplies. Dr. Charles Kennel of the Office of Mission to Planet Earth joined Dr.s Cordova, Kates, and Liverman for the question and answer session that followed.

Marine exotic isopods from the Iberian Peninsula and nearby waters

PubMed Central

Ros, Macarena; Guerra-García, José M.

2018-01-01

Effective management of marine bioinvasions starts with prevention, communication among the scientific community and comprehensive updated data on the distribution ranges of exotic species. Despite being a hotspot for introduction due to numerous shipping routes converging at the Strait of Gibraltar, knowledge of marine exotics in the Iberian Peninsula is scarce, especially of abundant but small-sized and taxonomically challenging taxa such as the Order Isopoda. To fill this gap, we conducted several sampling surveys in 44 marinas and provide the first comprehensive study of marine exotic isopods from the Iberian Peninsula, the southern side of the Strait of Gibraltar (northern Africa) and the Balearic Islands. Exotic species included Ianiropsis serricaudis (first record for the Iberian Peninsula and Lusitanian marine province), Paracerceis sculpta (first record for the Alboran Sea ecoregion), Paradella dianae, Paranthura japonica (earliest record for the Iberian Peninsula) and Sphaeroma walkeri. Photographs with morphological details for identification for non-taxonomic experts are provided, their worldwide distribution is updated and patterns of invasion are discussed. We report an expansion in the distribution range of all species, especially at the Strait of Gibraltar and nearby areas. Ianiropsis serricaudis and Paranthura japonica are polyvectic, with shellfish trade and recreational boating being most probable vectors for their introduction and secondary spread. The subsequent finding of the studied species in additional marinas over the years points at recreational boating as a vector and indicates a future spread. We call for attention to reduce lags in the detection and reporting of small-size exotics, which usually remain overlooked or underestimated until the invasion process is at an advanced stage. PMID:29507825

Prospective Assessment of Nocturnal Awakenings in a Case Series of Treatment-Seeking Chronic Insomnia Patients: A Pilot Study of Subjective and Objective Causes

PubMed Central

Krakow, Barry; Romero, Edward; Ulibarri, Victor A.; Kikta, Shara

2012-01-01

Background: The cause of nocturnal awakenings in patients with chronic insomnia is rarely researched. This study prospectively assessed the etiology of nocturnal awakenings (subjectively and objectively) among patients with insomnia at a private, community-based sleep medical center. Methods: Twenty adult patients with chronic insomnia enrolled between April 2008 and February 2010 met diagnostic criteria for an insomnia disorder, never previously visited a sleep specialist or underwent sleep testing, and reported no classic sleep disordered breathing symptoms. Patients completed validated scales for insomnia, sleepiness, impairment, anxiety, depression, and quality of life, a qualitative interview to assess subjective reasons for awakenings, and a diagnostic sleep study to objectively assess awakenings and their precipitants. Results: Subjective and objective data showed clinically meaningful insomnia, primarily sleep maintenance insomnia. The most common self-reported reasons for awakenings were: uncertain cause (50%), nightmares (45%), nocturia (35%), bedroom distractions (20%), or pain (15%). No patient identified breathing symptoms as a cause. Objectively, 531 awakenings were observed in the total sample, and 478 (90%) were preceded by sleep breathing events (apnea, hypopnea, or respiratory effort-related event). Fifty-three awakenings were caused by other factors (independent leg jerks [7], spontaneous [14], and sleep that was laboratory-induced [32]). Thirty awakenings ≥ 5 min—a duration sufficient to predispose toward an insomnia episode—were each preceded by a breathing event. Conclusions: Among patients with insomnia with no classic sleep breathing symptoms and therefore low probability of a sleep breathing disorder, most of their awakenings were precipitated by a medical condition (sleep disordered breathing), which contrasted sharply with their perceptions about their awakenings. Citation: Krakow B; Romero E; Ulibarri VA; Kikta S. Prospective assessment of nocturnal awakenings in a case series of treatment-seeking chronic insomnia patients: a pilot study of subjective and objective causes. SLEEP 2012;35(12):1685-1692. PMID:23204611

Effects of Combining Running and Practical Duration Stretching on Proprioceptive Skills of National Sprinters.

PubMed

Romero-Franco, Natalia; Párraga-Montilla, Juan Antonio; Molina-Flores, Enrique M; Jiménez-Reyes, Pedro

2018-06-01

Romero-Franco, N, Párraga-Montilla, JA, Molina-Flores, EM, and Jiménez-Reyes, P. Effects of combining running and practical duration stretching on proprioceptive skills of national sprinters. J Strength Cond Res XX(X): 000-000, 2018-Practical duration stretching after aerobic activities is a recommended component of the first part of warm-up because of its effects on performance. However, its effects on proprioceptive skills are unknown. This study aimed to analyze the effects of running and practical duration static stretching (SS) and dynamic stretching (DS) on postural balance and the joint position sense (JPS) of national sprinters. Thirty-two national sprinters were randomly classified into a SS group (n = 11), DS group (n = 11), or control group (n = 10). Static stretching performed 5 minutes of running and short-duration (20 seconds) static stretches; DS performed 5 minutes of running and short-duration dynamic (20 seconds) stretches; and the control group performed 5 minutes of running. Before and after the intervention, unipedal static postural balance and knee JPS were evaluated. Static stretching exhibited a more centralized center of pressure in the medial-lateral plane for unipedal static postural balance in right-leg support after stretching (p = 0.005, d = 1.24), whereas DS showed values further from the center after stretching for the same unipedal support compared with baseline (p = 0.042, d = 0.49), and the control group remained stable (p > 0.05). Joint position sense did not show significant differences in any group (p > 0.05). In conclusion, combining running and practical duration SS may be beneficial for right-leg postural stabilization, whereas DS may be partly and slightly deleterious. Both SS and DS combined with running and running alone have neutral effects on knee JPS. Sports professionals should consider running and practical duration SS as part of the warm-up of sprinters to partly improve unipedal static postural balance.

Dry-thermophilic anaerobic digestion of organic fraction of municipal solid waste: Methane production modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fdez-Gueelfo, L.A., E-mail: alberto.fdezguelfo@uca.es; Alvarez-Gallego, C.; Sales, D.

2012-03-15

Highlights: Black-Right-Pointing-Pointer Methane generation may be modeled by means of modified product generation model of Romero Garcia (1991). Black-Right-Pointing-Pointer Organic matter content and particle size influence the kinetic parameters. Black-Right-Pointing-Pointer Higher organic matter content and lower particle size enhance the biomethanization. - Abstract: The influence of particle size and organic matter content of organic fraction of municipal solid waste (OFMSW) in the overall kinetics of dry (30% total solids) thermophilic (55 Degree-Sign C) anaerobic digestion have been studied in a semi-continuous stirred tank reactor (SSTR). Two types of wastes were used: synthetic OFMSW (average particle size of 1 mm; 0.71more » g Volatile Solids/g waste), and OFMSW coming from a composting full scale plant (average particle size of 30 mm; 0.16 g Volatile Solids/g waste). A modification of a widely-validated product-generation kinetic model has been proposed. Results obtained from the modified-model parameterization at steady-state (that include new kinetic parameters as K, Y{sub pMAX} and {theta}{sub MIN}) indicate that the features of the feedstock strongly influence the kinetics of the process. The overall specific growth rate of microorganisms ({mu}{sub max}) with synthetic OFMSW is 43% higher compared to OFMSW coming from a composting full scale plant: 0.238 d{sup -1} (K = 1.391 d{sup -1}; Y{sub pMAX} = 1.167 L CH{sub 4}/gDOC{sub c}; {theta}{sub MIN} = 7.924 days) vs. 0.135 d{sup -1} (K = 1.282 d{sup -1}; Y{sub pMAX} = 1.150 L CH{sub 4}/gDOC{sub c}; {theta}{sub MIN} = 9.997 days) respectively. Finally, it could be emphasized that the validation of proposed modified-model has been performed successfully by means of the simulation of non-steady state data for the different SRTs tested with each waste.« less

Delphi consensus on the diagnosis and management of dyslipidaemia in chronic kidney disease patients: A post hoc analysis of the DIANA study.

PubMed

Cases Amenós, Aleix; Pedro-Botet Montoya, Juan; Pascual Fuster, Vicente; Barrios Alonso, Vivencio; Pintó Sala, Xavier; Ascaso Gimilio, Juan F; Millán Nuñez-Cortés, Jesús; Serrano Cumplido, Adalberto

This post hoc study analysed the perception of the relevance of chronic kidney disease (CKD) in dyslipidaemia screening and the choice of statin among primary care physicians (PCPs) and other specialists through a Delphi questionnaire. The questionnaire included 4blocks of questions concerning dyslipidaemic patients with impaired carbohydrate metabolism. This study presents the results of the impact of CKD on screening and the choice of statin. Of the 497 experts included, 58% were PCPs and 42% were specialists (35, 7% were nephrologists). There was consensus by both PCPs and specialists, with no difference between PCPs and specialists, that CKD patients should undergo a dyslipidaemia screening and that the screening should be part of routine clinical practice. However, there was no consensus in considering the estimated glomerular filtration rate (eGFR) (although there was consensus among PCPs and nephrologists), or considering albuminuria when selecting a statin, or in determining albuminuria during follow-up after having initiated treatment with statins (although there was consensus among the nephrologists). The consensus to analyse the lipid profile in CKD patients suggests acknowledgment of the high cardiovascular risk of this condition. However, the lack of consensus in considering renal function or albuminuria, both when selecting a statin and during follow-up, suggests a limited knowledge of the differences between statins in relation to CKD. Thus, it would be advisable to develop a guideline/consensus document on the use of statins in CKD. Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p.

PubMed

Zhang, Weiguang; Bi, Yunke; Li, Jianhua; Peng, Fei; Li, Hui; Li, Chenguang; Wang, Laizang; Ren, Fubin; Xie, Chen; Wang, Pengwei; Liang, Weiwei; Wang, Zhi; Zhu, Dan

2017-04-01

Gliomas remain a major public health challenge, posing a high risk for brain tumor-related morbidity and mortality. However, the mechanisms that drive the development of gliomas remain largely unknown. Emerging evidence has shown that long noncoding RNAs are key factors in glioma pathogenesis. qRT-PCR analysis was used to assess the expression of FTX and miR-342-3p in the different stages of gliomas in tissues. Bioinformatics tool DIANA and TargetSCan were used to predict the targets of FTX and miR-342-3p, respectively. Pearson's correlation analysis was performed to test the correlation between the expression levels of FTX, miR-342-3p, and astrocyte-elevated gene-1 (AEG-1). To examine the role of FTX in regulating proliferation and invasion of glioma cells, specific siRNA was used to knockdown FTX, and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and transwell assays were performed. Furthermore, rescue experiments were performed to further confirm the regulation of miR-342-3p by FTX. We then found that the expression of FTX and miR-342-3p was associated with progression of gliomas. FTX directly inhibited the expression of miR-342-3p, which subsequently regulates the expression of AEG-1. Collectively, FTX is critical for proliferation and invasion of glioma cells by regulating miR-342-3p and AEG-1. Our findings indicate that FTX and miR-342-3p may serve as a biomarker of glioma diagnosis, and offer potential novel therapeutic targets of treatment of gliomas.

Effect of spatial nonuniformity of heating on compression and burning of a thermonuclear target under direct multibeam irradiation by a megajoule laser pulse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bel’kov, S. A.; Bondarenko, S. V.; Vergunova, G. A.

Direct-drive fusion targets are considered at present as an alternative to targets of indirect compression at a laser energy level of about 2 MJ. In this approach, the symmetry of compression and ignition of thermonuclear fuel play the major role. We report on the results of theoretical investigation of compression and burning of spherical direct-drive targets in the conditions of spatial nonuniformity of heating associated with a shift of the target from the beam center of focusing and possible laser radiation energy disbalance in the beams. The investigation involves numerous calculations based on a complex of 1D and 2D codesmore » RAPID, SEND (for determining the target illumination and the dynamics of absorption), DIANA, and NUT (1D and multidimensional hydrodynamics of compression and burning of targets). The target under investigation had the form of a two-layer shell (ablator made of inertial material CH and DT ice) filled with DT gas. We have determined the range of admissible variation of compression and combustion parameters of the target depending on the variation of the spatial nonuniformity of its heating by a multibeam laser system. It has been shown that low-mode (long-wavelength) perturbations deteriorate the characteristics of the central region due to less effective conversion of the kinetic energy of the target shell into the internal energy of the center. Local initiation of burning is also observed in off-center regions of the target in the case of substantial asymmetry of irradiation. In this case, burning is not spread over the entire volume of the DT fuel as a rule, which considerably reduces the thermonuclear yield as compared to that in the case of spherical symmetry and central ignition.« less

Effects of metal contamination in situ on osmoregulation and oxygen consumption in the mudflat fiddler crab Uca rapax (Ocypodidae, Brachyura).

PubMed

Capparelli, Mariana V; Abessa, Denis M; McNamara, John C

2016-01-01

The contamination of estuaries by metals can impose additional stresses on estuarine species, which may exhibit a limited capability to adjust their regulatory processes and maintain physiological homeostasis. The mudflat fiddler crab Uca rapax is a typical estuarine crab, abundant in both pristine and contaminated areas along the Atlantic coast of Brazil. This study evaluates osmotic and ionic regulatory ability and gill Na(+)/K(+)-ATPase activity in different salinities (<0.5, 25 and 60‰ S) and oxygen consumption rates at different temperatures (15, 25 and 35°C) in U. rapax collected from localities along the coast of São Paulo State showing different histories of metal contamination (most contaminated Ilha Diana, Santos>Rio Itapanhaú, Bertioga>Picinguaba, Ubatuba [pristine reference site]). Our findings show that the contamination of U. rapax by metals in situ leads to bioaccumulation and induces biochemical and physiological changes compared to crabs from the pristine locality. U. rapax from the contaminated sites exhibit stronger hyper- and hypo-osmotic regulatory abilities and show greater gill Na(+)/K(+)-ATPase activities than crabs from the pristine site, revealing that the underlying biochemical machinery can maintain systemic physiological processes functioning well. However, oxygen consumption, particularly at elevated temperatures, decreases in crabs showing high bioaccumulation titers but increases in crabs with low/moderate bioaccumulation levels. These data show that U. rapax chronically contaminated in situ exhibits compensatory biochemical and physiological adjustments, and reveal the importance of studies on organisms exposed to metals in situ, particularly estuarine invertebrates subject to frequent changes in natural environmental parameters like salinity and temperature. Copyright © 2016. Published by Elsevier Inc.

Dental Blogs, Podcasts, and Associated Social Media: Descriptive Mapping and Analysis.

PubMed

Melkers, Julia; Hicks, Diana; Rosenblum, Simone; Isett, Kimberley R; Elliott, Jacqueline

2017-07-26

Studies of social media in both medicine and dentistry have largely focused on the value of social media for marketing to and communicating with patients and for clinical education. There is limited evidence of how dental clinicians contribute to and use social media to disseminate and access information relevant to clinical care. The purpose of this study was to inventory and assess the entry, growth, sources, and content of clinically relevant social media in dentistry. We developed an inventory of blogs, podcasts, videos, and associated social media disseminating clinical information to dentists. We assessed hosts' media activity in terms of their combinations of modalities, entry and exit dates, frequency of posting, types of content posted, and size of audience. Our study showed that clinically relevant information is posted by dentists and hygienists on social media. Clinically relevant information was provided in 89 blogs and podcasts, and topic analysis showed motives for blogging by host type: 55% (49 hosts) were practicing dentists or hygienists, followed by consultants (27 hosts, 30%), media including publishers and discussion board hosts (8 hosts, 9%), and professional organizations and corporations. We demonstrated the participation of and potential for practicing dentists and hygienists to use social media to share clinical and other information with practicing colleagues. There is a clear audience for these social media sites, suggesting a changing mode of information diffusion in dentistry. This study was a first effort to fill the gap in understanding the nature and potential role of social media in clinical dentistry. ©Julia Melkers, Diana Hicks, Simone Rosenblum, Kimberley R Isett, Jacqueline Elliott. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.07.2017.

Pricing products: juxtaposing affordability with quality appeal.

PubMed

1984-01-01

Choosing appropriate product prices is 1 of the most crucial steps in creating an effective contraceptive social marketing (CSM) sales campaign. The Social Marketing Forum conducted an informal survey of social marketing project managers, international contractors, and marketing consultants to determine how CSM programs cope with pricing problems and ways to circumvent some obstacles. According to Diana Altman, a family planning consultant, low prices that make products available to needy individuals are more important than the program's self sufficiency, yet if prices are too low, consumers think the products were unusable in the US and thus were dumped on local markets. Other key factors include commercial competition, spiraling inflation rates, and problems with rising prices and retailer/distributor margins. A sampling of per capita gross national products indicates the poverty level of most CSM projects' target market. Consequently, CSM projects must set low pices, regardless of program operating costs. The goal often is to increase the demand and availability for contraceptives. The fact that social marketing products must pass through retail networks to reach consumers complicates the pricing equation. To deal with the problem, India's Nirodh program gives a 25% margin to distributors/wholesalers, compared to 6% offered on most other goods. Retailers also receive a 25% margin, more than double the commercial rate. Once prices are set, increases pose hazards. Local government approval often is a prerequisite and can require lengthy negotiations. Market studies remain a valuable approach to effective pricing, according to PNA's Mallamad and other research consultants. They cite such effective research strategies as test marketing products and asking consumers how prices affect buying habits. Further, CSM projects can jump over some pricing hurdles through creative marketing. An effective pricing strategy alone cannot produce a successful CSM program. Pricing must accompany such factors as strong advertising, committed management, and adept salespersons.

Original Research: miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells.

PubMed

Cui, Guanghui; Liu, Donglei; Li, Weihao; Li, Yuhang; Liang, Youguang; Shi, Wensong; Zhao, Song

2017-01-01

Increasing evidence suggests that miR-194 is down-regulated in esophageal squamous cell carcinoma tumor tissue. However, the role and underlying mechanism of miR-194 in esophageal squamous cell carcinoma have not been well defined. We used DIANA, TargetScan and miRanda to perform target prediction analysis and found KDM5B is a potential target of miR-194. Based on these findings, we speculated that miR-194 might play a role in esophageal squamous cell carcinoma development and progression by regulation the expression of KDM5B. We detected the expression of miR-194 and KDM5B by quantitative real-time reverse transcription PCR (qRT-PCR) and Western blot assays, respectively, and found down-regulation of miR-194 and up-regulation of KDM5B existed in esophageal squamous cell carcinoma cell lines. By detecting proliferation, invasion and apoptosis of TE6 and TE14 cells transfected with miR-194 mimics or mimic control, miR-194 was found to inhibit proliferation and invasion and promote apoptosis of esophageal squamous cell carcinoma cells. miR-194 was further verified to regulate proliferation, apoptosis and invasion of esophageal squamous cell carcinoma cells by directly targeting KDM5B. Furthermore, animal studies were performed and showed that overexpression of miR-194 inhibited the growth of esophageal squamous cell carcinoma tumors in vivo. These results confirmed our speculation that miR-194 targets KDM5B to inhibit esophageal squamous cell carcinoma development and progression. These findings offer new clues for esophageal squamous cell carcinoma development and progression and novel potential therapeutic targets for esophageal squamous cell carcinoma. © 2016 by the Society for Experimental Biology and Medicine.

Spatial variation in mandibular bone elastic modulus and its effect on structural bending stiffness: A test case using the Taï Forest monkeys.

PubMed

Le, Kim N; Marsik, Matthew; Daegling, David J; Duque, Ana; McGraw, William Scott

2017-03-01

We investigated how heterogeneity in material stiffness affects structural stiffness in the cercopithecid mandibular cortical bone. We assessed (1) whether this effect changes the interpretation of interspecific structural stiffness variation across four primate species, (2) whether the heterogeneity is random, and (3) whether heterogeneity mitigates bending stress in the jaw associated with food processing. The sample consisted of Taï Forest, Cote d'Ivoire, monkeys: Cercocebus atys, Piliocolobus badius, Colobus polykomos, and Cercopithecus diana. Vickers indentation hardness samples estimated elastic moduli throughout the cortical bone area of each coronal section of postcanine corpus. For each section, we calculated maximum area moment of inertia, I max (structural mechanical property), under three models of material heterogeneity, as well as spatial autocorrelation statistics (Moran's I, I MORAN ). When the model considered material stiffness variation and spatial patterning, I max decreased and individual ranks based on structural stiffness changed. Rank changes were not significant across models. All specimens showed positive (nonrandom) spatial autocorrelation. Differences in I MORAN were not significant among species, and there were no discernable patterns of autocorrelation within species. Across species, significant local I MORAN was often attributed to proximity of low moduli in the alveolar process and high moduli in the basal process. While our sample did not demonstrate species differences in the degree of spatial autocorrelation of elastic moduli, there may be mechanical effects of heterogeneity (relative strength and rigidity) that do distinguish at the species or subfamilial level (i.e., colobines vs. cercopithecines). The potential connections of heterogeneity to diet and/or taxonomy remain to be discovered. © 2016 Wiley Periodicals, Inc.

In silico prediction of microRNAs on fluoride induced sperm toxicity in mice.

PubMed

Raghunath, Azhwar; Jeyabaskar, Dhivyalakshmi; Sundarraj, Kiruthika; Panneerselvam, Lakshmikanthan; Perumal, Ekambaram

2016-12-01

Fluorosis is an endemic global problem causing male reproductive impairment. F mediates male reproductive toxicity in mice down-regulating 63 genes involved in diverse biological processes - apoptosis, cell cycle, cell signaling, chemotaxis, electron transport, glycolysis, oxidative stress, sperm capacitation and spermatogenesis. We predicted the miRNAs down-regulating these 63 genes using TargetScan, DIANA and MicroCosm. The prediction tools identified 3059 miRNAs targeting 63 genes. Of the predicted interactions, 11 miRNAs (mmu-miR-103, -107, -122, -188a, -199a-5p, -205, -340-5p, -345-3p, -452-5p, -499, -878-3p) were commonly found in the three tools utilized and seven miRNAs (miR-9-5p, miR-511-3p, miR-7b-5p, miR-30e-5p, miR-17-5p, miR-122-5p and miR-541-5p) targeting six genes (Traf3, Rock2, Rgs8, Atp1b2, Cacna2d1 and Aldoa) were already validated experimentally in mice. The miRNA-mRNA network of the predicted miRNAs with its respective targets revealed the complex interaction within a biological process leading to sperm dysfunction on exposure to F. Our findings not only suggest that the predicted miRs furnish evidence, but also have the potential to serve as non-invasive biomarkers on F-induced sperm dysfunction. Our data contribute towards elucidating the function of miRNAs in the fluoride induced infertility. miRNA molecular pathways in F intoxication will open new avenues on the use of antagomirs in recovering fertility. Copyright © 2016 Elsevier Ltd. All rights reserved.

Microbial Extracellular Enzyme Activity and Community Assembly Processes Post Fire Disturbance Amanda Labrado, University of Texas at El Paso; Emily B. Graham, University of Colorado Boulder; Joseph E. Knelman, University of Colorado Boulder; Scott Ferrenberg, University of Colorado Boulder; Diana R. Nemergut, University of Colorado Boulder

NASA Astrophysics Data System (ADS)

Labrdo, A.; Knelman, J. E.; Graham, E. B.; Ferrenberg, S.; Nemergut, D. R.

2013-12-01

Microbes control major biogeochemical cycles and can directly impact the carbon, nitrogen, and phosphorus pools and fluxes of soils. However, many questions remain regarding when and where data on microbial community structure are necessary to accurately predict biogeochemical processes. In particular, it is unknown how shifts in microbial assembly processes may relate to changes in the relationship between community structure and ecosystem function. Here, we examine soil microbial community assembly processes and extracellular enzyme activity (EEA) at 4-weeks and 16-weeks after the Fourmile Canyon Fire in Boulder, CO in order to determine the effects of disturbance on community assembly and EEA. Microbial community structure was determined from 16S rRNA gene pyrosequencing, edaphic properties were determined using standard biogeochemical assays, and extracellular enzyme activity for β-1, 4-glucosidase (BG) and β-1, 4-N-acetylglucosaminidase (NAG) enzymes were determined using fluorimetric assays. Stepwise linear regressions were used to determine the effects of microbial community structure and edaphic factors on EEA. We determined that in 4-week post fire samples EEA was only correlated with microbial predictors. However, we observed a shift with 16-week samples in which EEA was significantly related to edaphic predictors. Null derivation analysis of community assembly revealed that communities in the 4-week samples were more neutrally assembled than communities in the 16-week samples. Together, these results support a conceptual model in which the relationship between edaphic factors and ecosystem processes is somewhat decoupled in more neutrally assembled communities, and data on microbial community structure is important to most accurately predict function.

PREFACE 16 ISCMP: Progress in Solid State and Molecular Electronics, Ionics and Photonics

NASA Astrophysics Data System (ADS)

Dimova-Malinovska, Doriana; Nesheva, Diana; Petrov, Alexander G.; Primatarowa, Marina T.

2010-11-01

We are pleased to introduce the Proceedings of the 16 ISCMP, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. The School was dedicated to the late Professor Joe Marshall, who served for a long time as Chairman and Honorary Chairman and left us just after having completed the proceedings of the previous School. Like previous events, the School took place in the beautiful Black Sea resort of Saint Constantine and Elena near Varna, going back to the renewed facilities of the Panorama hotel. Participants from 19 different countries delivered 34 invited lecturers and 75 posters, contributing to three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the articles published in this volume illustrate the diversity and the high level of the contributions. Not the least significant factor in the success of the 16 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. These Proceedings are published for the first time in Journal of Physics: Conference Series. We are grateful to the Journal's staff for encouraging this idea. The Scientific Committee of the ISCMP dedicates this volume of the Proceedings to the living memory of Professor Joe Marshall, Honorary Chairman of the ISCMP. The Committee decided that the next event will take place again in Saint Constantine and Elena, in September 2012. It will be entitled: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications. Doriana Dimova-Malinovska, Diana Nesheva, Alexander G Petrov and Marina T Primatarowa

MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis

PubMed Central

Danza, Katia; Summa, Simona De; Pinto, Rosamaria; Pilato, Brunella; Palumbo, Orazio; Merla, Giuseppe; Simone, Gianni; Tommasi, Stefania

2015-01-01

The involvement of microRNA (miRNAs), a new class of small RNA molecules, in governing angiogenesis has been well described. Our aim was to investigate miRNA-mediated regulation of angiogenesis in a series of familial breast cancers stratified by BRCA1/2 mutational status in BRCA carriers and BRCA non-carriers (BRCAX). Affymetrix GeneChip miRNA Arrays were used to perform miRNA expression analysis on 43 formalin-fixed paraffin-embedded (FFPE) tumour tissue familial breast cancers (22 BRCA 1/2-related and 21 BRCAX). Pathway enrichment analysis was carried out with the DIANA miRPath v2.0 web-based computational tool, and the miRWalk database was used to identify target genes of deregulated miRNAs. An independent set of 8 BRCA 1/2-related and 11 BRCAX breast tumors was used for validation by Real-Time PCR. In vitro analysis on HEK293, MCF-7 and SUM149PT cells were performed to best-clarify miR-573 and miR-578 role. A set of 16 miRNAs differentially expressed between BRCA 1/2-related and BRCAX breast tumors emerged from the profile analysis. Among these, miR-578 and miR-573 were found to be down-regulated in BRCA 1/2-related breast cancer and associated to the Focal adhesion, Vascular Endothelial Growth Factor (VEGF) and Hypoxia Inducible Factor-1 (HIF-1) signaling pathways. Our data highlight the role of miR-578 and miR-573 in controlling BRCA 1/2-related angiogenesis by targeting key regulators of Focal adhesion, VEGF and HIF-1 signaling pathways. PMID:25333258

PREFACE: 17th International School on Condensed Matter Physics (ISCMP): Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications

NASA Astrophysics Data System (ADS)

Dimova-Malinovska, Doriana; Nesheva, Diana; Pecheva, Emilia; Petrov, Alexander G.; Primatarowa, Marina T.

2012-12-01

We are pleased to introduce the Proceedings of the 17th International School on Condensed Matter Physics: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. Like prior events, the School took place in the beautiful Black Sea resort of Saints Constantine and Helena near Varna, going back to the refurbished facilities of the Panorama hotel. Participants from 17 different countries delivered 31 invited lecturers and 78 posters, contributing through three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the accepted papers illustrate the diversity and the high level of the contributions. Not least significant factor for the success of the 17 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. Visits to the Archaeological Museum (rich in valuable gold treasures of the ancient Thracian culture) and to the famous rock monastery Aladja were organized for the participants from the Varna Municipality. These Proceedings are published for the second time by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for supporting this idea. The Committee decided that the next event will take place again in Saints Constantine and Helena, 1-5 September 2014. It will be entitled: Challenges of the Nanoscale Science: Theory, Materials and Applications. Doriana Dimova-Malinovska, Diana Nesheva, Emilia Pecheva, Alexander G Petrov and Marina T Primatarowa Editors

Beyond offshoring: assess your company's global potential.

PubMed

Farrell, Diana

2004-12-01

In the past few years, companies have become aware that they can slash costs by offshoring: moving jobs to lower-wage locations. But this practice is just the tip of the iceberg in terms of how globalization can transform industries, according to research by the McKinsey Global Institute (MGI). The institute's yearlong study suggests that by streamlining their production processes and supply chains globally, rather than just nationally or regionally, companies can lower their costs-as we've seen in the consumer-electronics and PC industries. Companies can save as much as 70% of their total costs through globalization--50% from offshoring, 5% from training and business-task redesign, and 15% from process improvements. But they don't have to stop there. The cost reductions make it possible to lower prices and expand into new markets, attracting whole new classes of customers. To date, however, few businesses have recognized the full scope of performance improvements that globalization makes possible, much less developed sound strategies for capturing those opportunities. In this article, Diana Farrell, director of MGI, offers a step-by-step approach to doing both things. Among her suggestions: Assess where your industry falls along the globalization spectrum, because not all sectors of the economy face the same challenges and opportunities at the same time. Also, pay attention to production, regulatory, and organizational barriers to globalization. If any of these can be changed, size up the cost-saving (and revenue-generating) opportunities that will emerge for your company as a result of those changes. Farrell also defines the five stages of globalization-market entry, product specialization, value chain disaggregation, value chain reengineering, and the creation of new markets-and notes the different levers for cutting costs and creating value that companies can use in each phase.

Science Planning for the TROPIX Mission

NASA Technical Reports Server (NTRS)

Russell, C. T.

1998-01-01

The objective of the study grant was to undertake the planning needed to execute meaningful solar electric propulsion missions in the magnetosphere and beyond. The first mission examined was the Transfer Orbit Plasma Investigation Experiment (TROPIX) mission to spiral outward through the magnetosphere. The next mission examined was to the moon and an asteroid. Entitled Diana, it was proposed to NASA in October 1994. Two similar missions were conceived in 1996 entitled CNR for Comet Nucleus Rendezvous and MBAR for Main Belt Asteroid Rendezvous. The latter mission was again proposed in 1998. All four of these missions were unsuccessfully proposed to the NASA Discovery program. Nevertheless we were partially successful in that the Deep Space 1 (DS1) mission was eventually carried out nearly duplicating our CNR mission. Returning to the magnetosphere we studied and proposed to the Medium Class Explorer (MIDEX) program a MidEx mission called TEMPEST, in 1995. This mission included two solar electric spacecraft that spiraled outward in the magnetosphere: one at near 900 inclination and one in the equatorial plane. This mission was not selected for flight. Next we proposed a single SEP vehicle to carry Energetic Neutral Atom (ENA) imagers and inside observations to complement the IMAGE mission providing needed data to properly interpret the IMAGE data. This mission called SESAME was submitted unsuccessfully in 1997. One proposal was successful. A study grant was awarded to examine a four spacecraft solar electric mission, named Global Magnetospheric Dynamics. This study was completed and a report on this mission is attached but events overtook this design and a separate study team was selected to design a classical chemical mission as a Solar Terrestrial Probe. Competing proposals such as through the MIDEX opportunity were expressly forbidden. A bibliography is attached.

The major resistance gene cluster in lettuce is highly duplicated and spans several megabases.

PubMed Central

Meyers, B C; Chin, D B; Shen, K A; Sivaramakrishnan, S; Lavelle, D O; Zhang, Z; Michelmore, R W

1998-01-01

At least 10 Dm genes conferring resistance to the oomycete downy mildew fungus Bremia lactucae map to the major resistance cluster in lettuce. We investigated the structure of this cluster in the lettuce cultivar Diana, which contains Dm3. A deletion breakpoint map of the chromosomal region flanking Dm3 was saturated with a variety of molecular markers. Several of these markers are components of a family of resistance gene candidates (RGC2) that encode a nucleotide binding site and a leucine-rich repeat region. These motifs are characteristic of plant disease resistance genes. Bacterial artificial chromosome clones were identified by using duplicated restriction fragment length polymorphism markers from the region, including the nucleotide binding site-encoding region of RGC2. Twenty-two distinct members of the RGC2 family were characterized from the bacterial artificial chromosomes; at least two additional family members exist. The RGC2 family is highly divergent; the nucleotide identity was as low as 53% between the most distantly related copies. These RGC2 genes span at least 3.5 Mb. Eighteen members were mapped on the deletion breakpoint map. A comparison between the phylogenetic and physical relationships of these sequences demonstrated that closely related copies are physically separated from one another and indicated that complex rearrangements have shaped this region. Analysis of low-copy genomic sequences detected no genes, including RGC2, in the Dm3 region, other than sequences related to retrotransposons and transposable elements. The related but divergent family of RGC2 genes may act as a resource for the generation of new resistance phenotypes through infrequent recombination or unequal crossing over. PMID:9811791

PREFACE: 14th Latin American Workshop on Plasma Physics (LAWPP 2011)

NASA Astrophysics Data System (ADS)

Bilbao, Luis; Minotti, Fernando; Kelly, Hector

2012-06-01

These proceedings present the written contributions from participants of the Latin American Workshop on Plasma Physics (LAWPP), which was held in Mar del Plata, Argentina, on 20-25 November 2011. This was the 14th session of the series of LAWPP biennial meetings, which started in 1982. The five-day scientific program of LAWPP 2011 consisted of 32 talks and various poster sessions, with the participation of 135 researchers from Argentina, Brazil, Canada, Chile, Colombia, Mexico, Puerto Rico, USA, Venezuela, as well as others from Europe and Asia. In addition, a School on Plasma Physics and a Workshop on Industrial Applications of Plasma Technology (AITP) were organized together with the main meeting. The five-day School held in the week previous to the meeting was intended for young scientists starting their research in Plasma Physics. On the other hand, the objective of the AITP Workshop was to enhance regional academic and industrial cooperation in the field of plasma assisted surface technology. Topics addressed at LAWPP 2011 included space plasmas, dusty plasmas, nuclear fusion, non-thermal plasmas, basic plasma processes, plasma simulation and industrial plasma applications. This variety of subjects is reflected in these proceedings, which the editors hope will result in enjoyable and fruitful reading for those interested in Plasma Physics. It is a pleasure to thank the Institutions that sponsored the meeting, as well as all the participants and collaborators for making this meeting possible. The Editors Luis Bilbao, Fernando Minotti and Hector Kelly LAWPP participants Participants of the 14th Latin American Workshop on Plasma Physics, 20-25 November 2011, Mar del Plata, Argentina International Scientific Committee Carlos Alejaldre, Spain María Virginia Alves, Brazil Ibere Caldas, Brazil Luis Felipe Delgado-Aparicio, Peru Mayo Villagrán, Mexico Kohnosuke Sato, Japan Héctor Kelly, Argentina Edberto Leal-Quirós, Puerto Rico George Morales, USA Julio Puerta, Venezuela Leopoldo Soto, Chile Michael Tendler, Sweden Carlos Varandas, Portugal Henry Riascos, Colombia Ivan Vargas-Blanco, Costa Rica Local Organizing Committee Luis Bilbao (Chairman) Fernando Minotti (Vice-Chairman) Luis Bernal, UNMDP Alejandro Clausse, PLADEMA-CNEA Graciela Gnavi, INFIP, CONICET-UBA Fausto Gratton, INFIP, CONICET-UBA Diana Grondona, INFIP, CONICET-UBA Héctor Kelly, INFIP, CONICET-UBA Adriana Márquez, INFIP, CONICET-UBA María Milanese, UNCPBA César Moreno, INFIP, CONICET-UBA Sponsors Instituto de Física del Plasma (INFIP) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Comisión Nacional de Energía Atómica (CNEA) Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) Centro Latino-Americano de Física (CLAF) Universidad Nacional de Mar del Plata (UNMP) Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) Academia Nacional de Ciencias de Buenos Aires (ANCBA) Conference poster

Data Intensive Analysis of Biomolecular Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Straatsma, TP; Soares, Thereza A.

2007-12-01

The advances in biomolecular modeling and simulation made possible by the availability of increasingly powerful high performance computing resources is extending molecular simulations to biological more relevant system size and time scales. At the same time, advances in simulation methodologies are allowing more complex processes to be described more accurately. These developments make a systems approach to computational structural biology feasible, but this will require a focused emphasis on the comparative analysis of the increasing number of molecular simulations that are being carried out for biomolecular systems with more realistic models, multi-component environments, and for longer simulation times. Just asmore » in the case of the analysis of the large data sources created by the new high-throughput experimental technologies, biomolecular computer simulations contribute to the progress in biology through comparative analysis. The continuing increase in available protein structures allows the comparative analysis of the role of structure and conformational flexibility in protein function, and is the foundation of the discipline of structural bioinformatics. This creates the opportunity to derive general findings from the comparative analysis of molecular dynamics simulations of a wide range of proteins, protein-protein complexes and other complex biological systems. Because of the importance of protein conformational dynamics for protein function, it is essential that the analysis of molecular trajectories is carried out using a novel, more integrative and systematic approach. We are developing a much needed rigorous computer science based framework for the efficient analysis of the increasingly large data sets resulting from molecular simulations. Such a suite of capabilities will also provide the required tools for access and analysis of a distributed library of generated trajectories. Our research is focusing on the following areas: (1) the development of an efficient analysis framework for very large scale trajectories on massively parallel architectures, (2) the development of novel methodologies that allow automated detection of events in these very large data sets, and (3) the efficient comparative analysis of multiple trajectories. The goal of the presented work is the development of new algorithms that will allow biomolecular simulation studies to become an integral tool to address the challenges of post-genomic biological research. The strategy to deliver the required data intensive computing applications that can effectively deal with the volume of simulation data that will become available is based on taking advantage of the capabilities offered by the use of large globally addressable memory architectures. The first requirement is the design of a flexible underlying data structure for single large trajectories that will form an adaptable framework for a wide range of analysis capabilities. The typical approach to trajectory analysis is to sequentially process trajectories time frame by time frame. This is the implementation found in molecular simulation codes such as NWChem, and has been designed in this way to be able to run on workstation computers and other architectures with an aggregate amount of memory that would not allow entire trajectories to be held in core. The consequence of this approach is an I/O dominated solution that scales very poorly on parallel machines. We are currently using an approach of developing tools specifically intended for use on large scale machines with sufficient main memory that entire trajectories can be held in core. This greatly reduces the cost of I/O as trajectories are read only once during the analysis. In our current Data Intensive Analysis (DIANA) implementation, each processor determines and skips to the entry within the trajectory that typically will be available in multiple files and independently from all other processors read the appropriate frames.« less

Data Intensive Analysis of Biomolecular Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Straatsma, TP

2008-03-01

The advances in biomolecular modeling and simulation made possible by the availability of increasingly powerful high performance computing resources is extending molecular simulations to biological more relevant system size and time scales. At the same time, advances in simulation methodologies are allowing more complex processes to be described more accurately. These developments make a systems approach to computational structural biology feasible, but this will require a focused emphasis on the comparative analysis of the increasing number of molecular simulations that are being carried out for biomolecular systems with more realistic models, multi-component environments, and for longer simulation times. Just asmore » in the case of the analysis of the large data sources created by the new high-throughput experimental technologies, biomolecular computer simulations contribute to the progress in biology through comparative analysis. The continuing increase in available protein structures allows the comparative analysis of the role of structure and conformational flexibility in protein function, and is the foundation of the discipline of structural bioinformatics. This creates the opportunity to derive general findings from the comparative analysis of molecular dynamics simulations of a wide range of proteins, protein-protein complexes and other complex biological systems. Because of the importance of protein conformational dynamics for protein function, it is essential that the analysis of molecular trajectories is carried out using a novel, more integrative and systematic approach. We are developing a much needed rigorous computer science based framework for the efficient analysis of the increasingly large data sets resulting from molecular simulations. Such a suite of capabilities will also provide the required tools for access and analysis of a distributed library of generated trajectories. Our research is focusing on the following areas: (1) the development of an efficient analysis framework for very large scale trajectories on massively parallel architectures, (2) the development of novel methodologies that allow automated detection of events in these very large data sets, and (3) the efficient comparative analysis of multiple trajectories. The goal of the presented work is the development of new algorithms that will allow biomolecular simulation studies to become an integral tool to address the challenges of post-genomic biological research. The strategy to deliver the required data intensive computing applications that can effectively deal with the volume of simulation data that will become available is based on taking advantage of the capabilities offered by the use of large globally addressable memory architectures. The first requirement is the design of a flexible underlying data structure for single large trajectories that will form an adaptable framework for a wide range of analysis capabilities. The typical approach to trajectory analysis is to sequentially process trajectories time frame by time frame. This is the implementation found in molecular simulation codes such as NWChem, and has been designed in this way to be able to run on workstation computers and other architectures with an aggregate amount of memory that would not allow entire trajectories to be held in core. The consequence of this approach is an I/O dominated solution that scales very poorly on parallel machines. We are currently using an approach of developing tools specifically intended for use on large scale machines with sufficient main memory that entire trajectories can be held in core. This greatly reduces the cost of I/O as trajectories are read only once during the analysis. In our current Data Intensive Analysis (DIANA) implementation, each processor determines and skips to the entry within the trajectory that typically will be available in multiple files and independently from all other processors read the appropriate frames.« less

Use of local pastoral species to increase fodder production of the saline rangelands in southern Tunisia

NASA Astrophysics Data System (ADS)

Tlili, Abderrazak; Tarhouni, Mohamed; Cardà, Artemi; Neffati, Mohamed

2017-04-01

Climate changes associated with multiple destructive human activities accelerate the degradation process of the natural rangelands around the world and especially the vulnerable areas such as the dryland ecosystems (Anaya-Romero et al., 2015; Eskandari et al., 2016; Muños Rojas et al., 2016; Vicente-Serrano et al., 2016). The vegetation cover and the biomass production of these ecosystems are decreasing and this is resulting in land degradation due to the soil erosion and changes in soil quality due to the abuse and misuse of the soil resources (Cerdà et al., 2016; Prosdocimi et al., 2016; Keesstra et al., 2016). To cope with such threats, it is necessary to develop some management techniques (restoration, plantation…) to enhance the biomass production and the carbon sequestration of the degraded rangelands (Muñoz-Rojas et al., 2016; Tarhouni et al., 2016). The valorization of saline water by planting pastoral halophyte species in salt-affected soils as well as the marginal areas are considered among the valuable tools to increase the rangeland production in dry areas. In this work, the ability of four plants (Atriplex halimus L. (Amaranthaceae), Atriplex mollis Desf. (Amaranthaceae), Lotus creticus L. (Fabaceae) and Cenchrus ciliaris L. (Poaceae)) to grow and to produce are tested under a field saline conditions (water and soil). Non-destructive method (Vegmeasure) is used to estimate the biomass production of these species. Chemical (crude protein, moisture and ash contents) and biochemical analyses (sugars, tannins and polyphenols contents) are also undertaken. Two years after plantation, the obtained results showed the ability of the four species to survive and to grow under high salinity degree. A strong positive correlation was obtained between the canopy cover and the dry biomass of the four studied species. Hence, the restoration of saline soils can be ensured by planting local halophytes. Acknowledgements. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 603498 (RECARE project) References Anaya-Romero, M., S. K. Abd-Elmabod, M. Muñoz-Rojas, G. Castellano, C. J. Ceacero, S. Alvarez, M. Méndez, and D. De la Rosa. 2015. Evaluating Soil Threats Under Climate Change Scenarios in the Andalusia Region, Southern Spain. Land Degradation and Development 26 (5): 441-449. doi:10.1002/ldr.2363. Cerdà, A., González-Pelayo, O., Giménez-Morera, A., Jordán, A., Pereira, P., Novara, A., Brevik, E.C., Prosdocimi, M., Mahmoodabadi, M., Keesstra, S., García Orenes, F., Ritsema, C., 2016. The use of barley straw residues to avoid high erosion and runoff rates on persimmon plantations in Eastern Spain under low frequency - high magnitude simulated rainfall events. Soil Res, 54, 2, 154-165 DOI: 10.1071/SR15092 Eskandari, H., Borji, M., Khosravi, H., Mesbahzadeh, T. Desertification of forest, range and desert in Tehran province, affected by climate change. (2016) Solid Earth, 7 (3), pp. 905-915. DOI: http://dx.doi.org/10.5194/se-7-905-2016 Keesstra, S., P. Pereira, A. Novara, E. C. Brevik, C. Azorin-Molina, L. Parras-Alcántara, A. Jordán, and A. Cerdà. 2016. Effects of Soil Management Techniques on Soil Water Erosion in Apricot Orchards. Science of the Total Environment 551-552: 357-366. doi:10.1016/j.scitotenv.2016.01.182. Mengistu, D., W. Bewket, and R. Lal. 2016. Conservation Effects on Soil Quality and Climate Change Adaptability of Ethiopian Watersheds. Land Degradation and Development 27 (6): 1603-1621. doi:10.1002/ldr.2376. Muñoz-Rojas, M., Erickson, T.E., Martini, D., Dixon, K.D., Merritt, D.J (2016) Climate and soil factors influencing seedling recruitment of plant species used for dryland restoration. SOIL 2:1-11, DOI: 10.5194/soil-2016-25 Prosdocimi, M., A. Jordán, P. Tarolli, S. Keesstra, A. Novara, and A. Cerdà. 2016. The Immediate Effectiveness of Barley Straw Mulch in Reducing Soil Erodibility and Surface Runoff Generation in Mediterranean Vineyards. Science of the Total Environment 547: 323-330. doi:10.1016/j.scitotenv.2015.12.076. Tarhouni, M., W. Ben Hmida, and M. Neffati. 2015. Long-Term Changes in Plant Life Forms as a Consequence of Grazing Exclusion Under Arid Climatic Conditions. Land Degradation and Development. doi:10.1002/ldr.2407. Vicente-Serrano, S. M. 2016. Foreword: Drought Complexity and Assessment Under Climate Change Conditions. Cuadernos De Investigacion Geografica 42 (1): 7-11. doi:10.18172/cig.2961.

Differences in Muscle Activity During Cable Resistance Training Are Influenced by Variations in Handle Types.

PubMed

Rendos, Nicole K; Heredia Vargas, Héctor M; Alipio, Taislaine C; Regis, Rebeca C; Romero, Matthew A; Signorile, Joseph F

2016-07-01

Rendos, NK, Heredia Vargas, HM, Alipio, TC, Regis, RC, Romero, MA, and Signorile, JF. Differences in muscle activity during cable resistance training are influenced by variations in handle types. J Strength Cond Res 30(7): 2001-2009, 2016-There has been a recent resurgence in the use of cable machines for resistance training allowing movements that more effectively simulate daily activities and sports-specific movements. By necessity, these devices require a machine/human interface through some type of handle. Considerable data from material handling, industrial engineering, and exercise training studies indicate that handle qualities, especially size and shape, can significantly influence force production and muscular activity, particularly of the forearm muscles, which affect the critical link in activities that require object manipulation. The purpose for this study was to examine the influence of three different handle conditions: standard handle (StandH), ball handle with the cable between the index and middle fingers (BallIM), and ball handle with the cable between the middle and ring fingers (BallMR), on activity levels (rmsEMG) of the triceps brachii lateral and long heads (TriHLat, TriHLong), brachioradialis (BR), flexor carpi radialis (FCR), extensor carpi ulnaris, and extensor digitorum (ED) during eight repetitions of standing triceps pushdown performed from 90° to 0° elbow flexion at 1.5 s per contractile stage. Handle order was randomized. No significant differences were seen for triceps or BR rmsEMG across handle conditions; however, relative patterns of activation did vary for the forearm muscles by handle condition, with more coordinated activation levels for the FCR and ED during the ball handle conditions. In addition, the rmsEMG for the ED was significantly higher during the BallIM than any other condition and during the BallMR than the StandH. These results indicate that the use of ball handles with the cable passing between different fingers can vary the utilization patterns of selected forearm muscles and may therefore be advantageous for coaches, personal trainers, therapists, or bodybuilders for targeted training or rehabilitation of these muscles.

Web-Based Interventions to Improve Mental Health, General Caregiving Outcomes, and General Health for Informal Caregivers of Adults With Chronic Conditions Living in the Community: Rapid Evidence Review.

PubMed

Ploeg, Jenny; Markle-Reid, Maureen; Valaitis, Ruta; McAiney, Carrie; Duggleby, Wendy; Bartholomew, Amy; Sherifali, Diana

2017-07-28

Most adults with chronic conditions live at home and rely on informal caregivers to provide support. Caregiving can result in negative impacts such as poor mental and physical health. eHealth interventions may offer effective and accessible ways to provide education and support to informal caregivers. However, we know little about the impact of Web-based interventions for informal caregivers of community-dwelling adults with chronic conditions. The purpose of this rapid evidence review was to assess the impact of Web-based interventions on mental health, general caregiving outcomes, and general health for informal caregivers of persons with chronic conditions living in the community. A rapid evidence review of the current literature was employed to address the study purpose. EMBASE, MEDLINE, PsychInfo, CINAHL, Cochrane, and Ageline were searched covering all studies published from January 1995 to July 2016. Papers were included if they (1) included a Web-based modality to deliver an intervention; (2) included informal, unpaid adult caregivers of community-living adults with a chronic condition; (3) were either a randomized controlled trial (RCT) or controlled clinical trial (CCT); and (4) reported on any caregiver outcome as a result of use or exposure to the intervention. A total of 20 papers (17 studies) were included in this review. Study findings were mixed with both statistically significant and nonsignificant findings on various caregiver outcomes. Of the 17 included studies, 10 had at least one significant outcome. The most commonly assessed outcome was mental health, which included depressive symptoms, stress or distress, and anxiety. Twelve papers examined the impact of interventions on the outcome of depressive symptoms; 4 found a significant decrease in depressive symptoms. Eight studies examined the outcome of stress or distress; 4 of these found a significant reduction in stress or distress as a result of the intervention. Three studies examined the outcome of anxiety; 2 of these found significant reductions in anxiety. Other significant results of the interventions were seen in the outcomes of caregiver gain (ie, positive aspects of caregiving), knowledge, bonding, reduction of anger-hostility, and negative mood. Based on this review, it is not possible to determine which interventions were most effective since studies differed in their design, sample, and intervention. Study results suggest that Web-based interventions may result in reduced depressive symptoms, anxiety, and stress or distress among informal caregivers of adults with chronic conditions in the community. This is the first review assessing the impact of Web-based technologies on mental health, general caregiving outcomes, and general health for caregivers of adults with chronic conditions living in the community. Further rigorous research is needed that includes adequately powered studies examining the critical components of the intervention and the dosage needed to have an effect. ©Jenny Ploeg, Maureen Markle-Reid, Ruta Valaitis, Carrie McAiney, Wendy Duggleby, Amy Bartholomew, Diana Sherifali. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 28.07.2017.

Effect of Surface Alloying by Silicon on the Corrosion Resistance and Biocompatibility of the Binary NiTi

NASA Astrophysics Data System (ADS)

Psakhie, S. G.; Meisner, S. N.; Lotkov, A. I.; Meisner, L. L.; Tverdokhlebova, A. V.

2014-07-01

This paper presents the study on changes in element and phase compositions in the near-surface layer and on surface topography of the NiTi specimens after the silicon ion-beam treatment. The effect of these parameters of the near-surface layer on corrosion properties in biochemical solutions and biocompatibility with mesenchymal stem cells of rat marrow is studied. Ion-beam surface modification of the specimens was performed by a DIANA-3 implanter (Tomsk, Russia), using single-ion-beam pulses under oil-free pumping and high vacuum (10-4 Pa) conditions in a high-dose ion implantation regime. The fluence made 2 × 1017 cm-2, at an average accelerating voltage of 60 kV, and pulse repetition frequency of 50 Hz. The silicon ion-beam treatment of specimen surfaces is shown to bring about a nearly twofold improvement in the corrosion resistance of the material to attack by aqueous solutions of NaCl (artificial body fluid) and human plasma and a drastic decrease in the nickel concentration after immersion of the specimens into the solutions for ~3400 and ~6000 h, respectively (for the artificial plasma solution, a nearly 20-fold decrease in the Ni concentration is observed). It is shown that improvement of NiTi corrosion resistance after treatment by Si ions occurs mainly due to the formation of two-layer composite coating based on Ti oxides (outer layer) on the NiTi surface and adjacent inner layer of oxides, carbides, and silicides of the NiTi alloy components. Inner layer with high silicon concentration serves as a barrier layer preventing nickel penetration into biomedium. This, in our opinion, is the main reason why the NiTi alloy exhibits no cytotoxic properties after ion modification of its surface and leads to the biocompatibility improvement at the cellular level, respectively.

The role of vasoactive intestinal peptide in neuroprotection: Professor Illana Gozes is interviewed by Emma Quigley.

PubMed

Gozes, Illana

2007-06-01

Professor Illana Gozes was interviewed by Emma Quigley (Senior Editor, Expert Opinion) on 17(th) April 2007. Professor Illana Gozes BSc, PhD holds the titles of Professor of Clinical Biochemistry; The Lily and Avraham Gildor Chair for the Investigation of Growth Factors; Director of Adams Super Center for Brain Studies and Levi-Edersheim-Gitter fMRI Institute; Head of the Dr Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology, Tel Aviv University and Chief Scientific Officer, Allon Therapeutics, Inc., Vancouver BC, Canada. Professor Gozes has served as a member (or chair) of several faculty, university or national and international committees and she currently serves on the Board of Directors of Allon Therapeutics, the Scientific Review Board of the ISOA, and is the Editor-in-Chief of the Journal of Molecular Neuroscience. Professor Gozes has received a number of scientific awards for her work including the Landau Award for an excellent PhD dissertation, the Juludan Prize and the Teva Founders Prize for exceptional scientific studies that may lead to biotechnology developments as well as the Bergmann Prize and the Neufeld award for outstanding/leading US-Israel BSF grant proposals, and has published extensively in the fields of molecular neuroscience and neuroprotection (> 200 scientific manuscripts). She is co-inventor of > 15 patents and applications, including the composition of matter patent on AL-108 and AL-208, Allon's lead compounds. Professor Gozes received a BSc from Tel Aviv University, a PhD from The Weizmann Institute of Science and was a Weizmann Postdoctoral Fellow at Massachusetts Institute of Technology, Research Associate/Visiting Scientist at the Salk Institute and the Scripps Clinic and Research Foundation, a Senior Scientist/Associate Professor at the Weizmann Institute and a Fogarty-Scholar-in-Residence at the National Institutes of Health (USA). Professor Gozes directs a very active research laboratory at Tel Aviv University and is mentoring and has mentored directly approximately 50 graduate students toward their MSc or PhD degrees.

Gulf of Mexico Gas Hydrate Joint Industry Project Leg II: Results from the Alaminos Canyon 21 Site

NASA Astrophysics Data System (ADS)

Godfriaux, P. D.; Shedd, W.; Frye, M.; Collett, T. S.; Lee, M. W.; Boswell, R. M.; Cook, A.; Mrozewski, S.; Guerin, G.; McConnell, D.; Dufrene, R.; Jones, E.

2009-12-01

The Gulf of Mexico Gas Hydrate Joint Industry Project Leg II drilling program visited three sites in the Gulf of Mexico during a 21 day drilling program in April and May, 2009. Using both petroleum systems and seismic stratigraphic approaches, the exploration focus for Leg II was to identify sites with the potential for gas hydrate-saturated sand reservoirs. Two holes were drilled at the AC 21 site in the Diana Basin located in the western Gulf of Mexico. The data acquired consist of a comprehensive suite of high resolution LWD logs including gamma ray, density, porosity, sonic, and resistivity tools. No physical samples were taken in the field. The primary objective of each well was to determine the presence or absence of gas hydrate from the log data at the predetermined primary targets in a Pleistocene basin floor turbidite complex approximately 500 ft below seafloor. At the AC 21-A location, two high net to gross target sands were encountered that measured 15 ft and 60 ft, respectively. The AC 21-A well was drilled through the interpreted base of gas hydrate stability to a depth approximately 1500 ft below sea floor. The AC 21-B well encountered a single high net to gross target sand measuring over 120 ft thick. At both AC 21 well locations, all target sand intervals had elevated formation resistivity measurements relative to clearly wet, stratigraphically equivalent sands encountered in the region, interpreted to indicate low to moderate levels of gas hydrate saturation. The likely discovery of thick gas hydrate-filled sands at the AC 21 site validates the exploration approach, and strongly indicates that gas hydrate can be found in reservoir quality sands. The LWD acquired data provided unprecedented information on the nature of the sediments and the occurrence of gas hydrate in the Gulf of Mexico.

miRNAs and other non-coding RNAs in posttraumatic stress disorder: A systematic review of clinical and animal studies.

PubMed

Schmidt, Ulrike; Keck, Martin E; Buell, Dominik R

2015-06-01

In the last couple of years, non-coding (nc) RNAs like micro-RNAs (miRNAs), small interference RNAs (siRNAs) and long ncRNAs (lncRNAs) have emerged as promising candidates for biomarkers and drug-targets in a variety of psychiatric disorders. In contrast to reports on ncRNAs in affective disorders, schizophrenia and anxiety disorders, manuscripts on ncRNAs in posttraumatic stress disorder (PTSD) and associated animal models are scarce. Aiming to stimulate ncRNA research in PTSD and to identify the hitherto most promising ncRNA candidates and associated pathways for psychotrauma research, we conducted the first review on ncRNAs in PTSD. We aimed to identify studies reporting on the expression, function and regulation of ncRNAs in PTSD patients and in animals exhibiting a PTSD-like syndrome. Following the PRISMA guidelines for systematic reviews, we systematically screened the PubMed database for clinical and animal studies on ncRNAs in PTSD, animal models for PTSD and animal models employing a classical fear conditioning paradigm. Using 112 different combinations of search terms, we retrieved 523 articles of which we finally included and evaluated three clinical and 12 animal studies. In addition, using the web-based tool DIANA miRPath v2.0, we searched for molecular pathways shared by the predicted targets of the here-evaluated miRNA candidates. Our findings suggest that mir-132, which has been found to be regulated in three of the here included studies, as well as miRNAs with an already established role in Alzheimer's disease (AD) seem to be particularly promising candidates for future miRNA studies in PTSD. These results are limited by the low number of human trials and by the heterogeneity of included animal studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

MicroRNA profiling in intraocular medulloepitheliomas.

PubMed

Edward, Deepak P; Alkatan, Hind; Rafiq, Qundeel; Eberhart, Charles; Al Mesfer, Saleh; Ghazi, Nicola; Al Safieh, Leen; Kondkar, Altaf A; Abu Amero, Khaled K

2015-01-01

To study the differential expression of microRNA (miRNA) profiles between intraocular medulloepithelioma (ME) and normal control tissue (CT). Total RNA was extracted from formalin fixed paraffin embedded (FFPE) intraocular ME (n=7) and from age matched ciliary body controls (n=8). The clinical history and phenotype was recorded. MiRNA profiles were determined using the Affymetrix GeneChip miRNA Arrays analyzed using expression console 1.3 software. Validation of significantly dysregulated miRNA was confirmed by quantitative real-time PCR. The web-based DNA Intelligent Analysis (DIANA)-miRPath v2.0 was used to perform enrichment analysis of differentially expressed (DE) miRNA gene targets in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. The pathologic evaluation revealed one benign (benign non-teratoid, n=1) and six malignant tumors (malignant teratoid, n=2; malignant non-teratoid, n = 4). A total of 88 miRNAs were upregulated and 43 miRNAs were downregulated significantly (P<0.05) in the tumor specimens. Many of these significantly dysregulated miRNAs were known to play various roles in carcinogenesis and tumor behavior. RT-PCR validated three significantly upregulated miRNAs and three significantly downregulated miRNAs namely miR-217, miR-216a, miR-216b, miR-146a, miR-509-3p and miR-211. Many DE miRNAs that were significant in ME tumors showed dysregulation in retinoblastoma, glioblastoma, and precursor, normal and reactive human cartilage. Enriched pathway analysis suggested a significant association of upregulated miRNAs with 15 pathways involved in prion disease and several types of cancer. The pathways involving significantly downregulated miRNAs included the toll-like receptor (TLR) (p<4.36E-16) and Nuclear Factor kappa B (NF-κB) signaling pathways (p<9.00E-06). We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis of all dysregulated miRNAs shared commonalities with other cancer pathways.

PREFACE: 2nd International Conference on Innovative Materials, Structures and Technologies

NASA Astrophysics Data System (ADS)

Ručevskis, Sandris

2015-11-01

The 2nd International Conference on Innovative Materials, Structures and Technologies (IMST 2015) took place in Riga, Latvia from 30th September - 2nd October, 2015. The first event of the conference series, dedicated to the 150th anniversary of the Faculty of Civil Engineering of Riga Technical University, was held in 2013. Following the established tradition, the aim of the conference was to promote and discuss the latest results of industrial and academic research carried out in the following engineering fields: analysis and design of advanced structures and buildings; innovative, ecological and energy efficient building materials; maintenance, inspection and monitoring methods; construction technologies; structural management; sustainable and safe transport infrastructure; and geomatics and geotechnics. The conference provided an excellent opportunity for leading researchers, representatives of the industrial community, engineers, managers and students to share the latest achievements, discuss recent advances and highlight the current challenges. IMST 2015 attracted over 120 scientists from 24 countries. After rigorous reviewing, over 80 technical papers were accepted for publication in the conference proceedings. On behalf of the organizing committee I would like to thank all the speakers, authors, session chairs and reviewers for their efficient and timely effort. The 2nd International Conference on Innovative Materials, Structures and Technologies was organized by the Faculty of Civil Engineering of Riga Technical University with the support of the Latvia State Research Programme under the grant agreement "INNOVATIVE MATERIALS AND SMART TECHNOLOGIES FOR ENVIRONMENTAL SAFETY, IMATEH". I would like to express sincere gratitude to Juris Smirnovs, Dean of the Faculty of Civil Engineering, and Andris Chate, manager of the Latvia State Research Programme. Finally, I would like to thank all those who helped to make this event happen. Special thanks go to Diana Bajare, Laura Sele, Liga Radina and Jana Galilejeva for their major contribution to organizing the conference and to the literary editor Tatjana Smirnova and technical editor Daira Erdmane for their hard work on the conference proceedings.

In Silico Prediction and Validation of Gfap as an miR-3099 Target in Mouse Brain.

PubMed

Abidin, Shahidee Zainal; Leong, Jia-Wen; Mahmoudi, Marzieh; Nordin, Norshariza; Abdullah, Syahril; Cheah, Pike-See; Ling, King-Hwa

2017-08-01

MicroRNAs are small non-coding RNAs that play crucial roles in the regulation of gene expression and protein synthesis during brain development. MiR-3099 is highly expressed throughout embryogenesis, especially in the developing central nervous system. Moreover, miR-3099 is also expressed at a higher level in differentiating neurons in vitro, suggesting that it is a potential regulator during neuronal cell development. This study aimed to predict the target genes of miR-3099 via in-silico analysis using four independent prediction algorithms (miRDB, miRanda, TargetScan, and DIANA-micro-T-CDS) with emphasis on target genes related to brain development and function. Based on the analysis, a total of 3,174 miR-3099 target genes were predicted. Those predicted by at least three algorithms (324 genes) were subjected to DAVID bioinformatics analysis to understand their overall functional themes and representation. The analysis revealed that nearly 70% of the target genes were expressed in the nervous system and a significant proportion were associated with transcriptional regulation and protein ubiquitination mechanisms. Comparison of in situ hybridization (ISH) expression patterns of miR-3099 in both published and in-house-generated ISH sections with the ISH sections of target genes from the Allen Brain Atlas identified 7 target genes (Dnmt3a, Gabpa, Gfap, Itga4, Lxn, Smad7, and Tbx18) having expression patterns complementary to miR-3099 in the developing and adult mouse brain samples. Of these, we validated Gfap as a direct downstream target of miR-3099 using the luciferase reporter gene system. In conclusion, we report the successful prediction and validation of Gfap as an miR-3099 target gene using a combination of bioinformatics resources with enrichment of annotations based on functional ontologies and a spatio-temporal expression dataset.

Dehydration triggers differential microRNA expression in Xenopus laevis brain.

PubMed

Luu, Bryan E; Storey, Kenneth B

2015-11-15

African clawed frogs, Xenopus laevis, although primarily aquatic, have a high tolerance for dehydration, being capable of withstanding the loss of up to 32-35% of total water body water. Recent studies have shown that microRNAs play a role in the response to dehydration by the liver, kidney and ventral skin of X. laevis. MicroRNAs act by modulating the expression of mRNA transcripts, thereby affecting diverse biochemical pathways. In this study, 43 microRNAs were assessed in frog brains comparing control and dehydrated (31.2±0.83% of total body water lost) conditions. MicroRNAs of interest were measured using a modified protocol which employs polyadenylation of microRNAs prior to reverse transcription and qPCR. Twelve microRNAs that showed a significant decrease in expression (to 41-77% of control levels) in brains from dehydrated frogs (xla-miR-15a, -150, -181a, -191, -211, -218, -219b, -30c, -30e, -31, -34a, and -34b) were identified. Genomic analysis showed that the sequences of these dehydration-responsive microRNAs were highly conserved as compared with the comparable microRNAs of mice (91-100%). Suppression of these microRNAs implies that translation of the mRNA transcripts under their control could be enhanced in response to dehydration. Bioinformatic analysis using the DIANA miRPath program (v.2.0) predicted the top two KEGG pathways that these microRNAs collectively regulate: 1. Axon guidance, and 2. Long-term potentiation. Previous studies indicated that suppression of these microRNAs promotes neuroprotective pathways by increasing the expression of brain-derived neurotrophic factor and activating anti-apoptotic pathways. This suggests that similar actions may be triggered in X. laevis brains as a protective response to dehydration. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ortiz de Montellano, B.

As planned a letter was sent out to 17 teachers who had participated in a Summer 1994 workshop on ``Culturally Relevant Science for Hispanics`` at Michigan State. These teachers were supposed to have spent the intervening time developing lesson plans and curricula. The letter requested a report of any activities undertaken and copies of lesson plans and materials developed by February 1996 with a stipend of $400 for satisfactory reports. It was a disappointment to only get 9 responses and not all of them demonstrating a satisfactory level of activity. Diana Marinez, Dean of Science at Texas A and Mmore » University, Corpus Christi, who is the other developer of this curriculum and the author reviewed the submitted materials and chose those showing the most promise to be invited to participate in the Summer Writing Workshop. Spring of 1996 and particularly in May--June, the author wrote a partial first draft of a companion volume for the teacher`s manual which would provide a rationale for doing culturally relevant science, present the cultural and the scientific background that teachers would need in order to be able to teach. One of the goals of this curriculum is that it should be off-the-shelf ready to teach and that teachers would not have to do extra research to encourage its adoption. The outline of the book is appendix 1. The Writing Workshop was held at Texas A and M University, Corpus Christi from July 14 to July 27, 1996. Participating teachers chose topics that they were interested in developing and wrote first drafts. These were distributed to all participants and critiqued by the workshop directors before being rewritten. Some teachers were more productive than others depending on their science background. In total an impressive number of lesson plans were written. These lesson plans are listed in Appendix 3. Appendix 4 is a sample lesson. Work still needs to be done on both the source book and the teachers` manual.« less

A Diabetes Self-Management Program: 12-Month Outcome Sustainability From a Nonreinforced Pragmatic Trial.

PubMed

Lorig, Kate; Ritter, Philip L; Turner, Ralph M; English, Kathleen; Laurent, Diana D; Greenberg, Jay

2016-12-15

Diabetes self-management education has been shown to be effective in controlled trials. The 6-week Better Choices, Better Health-Diabetes (BCBH-D) self-management program was also associated with an improvement in health outcomes in a 6-month translation study. The objective of this study was to determine whether a national translation of the BCBH-D self-management program, offered both Web-based and face-to-face, was associated with improvements in health outcomes (including HbA1c) and health behaviors (including recommended medical tests) 1 year after intervention. Web-based programs were administered nationally, whereas face-to-face workshops took place in Atlanta, Indianapolis, and St Louis. Self-report questionnaires were either Web-based or administered by mail, at baseline and 1 year, and collected health and health-behavior measures. HbA1c blood samples were collected via mailed kits. A previous 6-month study found statistically significant improvements in 13 of 14 outcome measures, including HbA1c. For this study, paired t test compared baseline with 1-year outcomes. Subgroup analyses determined whether participants with specific conditions improved (high HbA1c, depression, hypoglycemia, nonadherence to medication, no aerobic exercise). The percentage of participants with improvements in effect size of at least 0.4 in at least 1 of the 5 measures was calculated. A total of 857 participants with 1-year data (69.7% of baseline participants) demonstrated statistically significant 1-year improvements in 13 of 15 outcome measures; 79.9% (685/857) of participants showed improvements in effect size of 0.4 or greater in at least 1 of the 5 criterial measures. Participants had small but significant benefits in multiple measures. Improvements previously noted at 6 months were maintained or amplified at 1 year. ©Kate Lorig, Philip L Ritter, Ralph M Turner, Kathleen English, Diana D Laurent, Jay Greenberg. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 15.12.2016.

Quality of Social Media and Web-Based Information Regarding Inappropriate Nuclear Cardiac Stress Testing and the Choosing Wisely Campaign: A Cross-Sectional Study.

PubMed

Winchester, David E; Baxter, Diana; Markham, Merry J; Beyth, Rebecca J

2017-05-04

The World Wide Web and social media provide the public with access to medical information unlike any other time in human history. However, the quality of content related to cardiac stress testing is not well understood. The aim of our study was to evaluate the quality of content on the Internet relating to the use of cardiac nuclear stress testing and the Choosing Wisely campaign. We searched the World Wide Web, Google Video (including YouTube), and Twitter for information relating to these two topics. Searches were performed using English language terms from a computer in the United States not logged into any personal user accounts. Search results were reviewed for discussion of specific topics including radiation risk, accuracy of testing, alternative testing options, and discouragement of inappropriate test use. We evaluated a total of 348 items of content from our searches. Relevant search results for Choosing Wisely were fewer than for other search terms (45 vs 303). We did not find any content which encouraged inappropriate testing (ie, screening in low risk individuals or testing prior to low risk operations). Content related to Choosing Wisely was more likely to discourage inappropriate testing than search results for other terms (29/45, 64% vs 12/303, 4.0%, odds ratio 43.95, 95% CI 17.6-112.2, P<.001). The Internet content on nuclear stress tests consistently discouraged inappropriate testing. The Choosing Wisely content was more likely to discourage inappropriate testing, less relevant content was available. Generating authoritative content on the Internet relating to judicious use of medical interventions may be an important role for the Choosing Wisely campaign. ©David E Winchester, Diana Baxter, Merry J Markham, Rebecca J Beyth. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 04.05.2017.

A non-invasive spectroscopic study to evaluate both technological features and conservation state of two types of ancient Roman coloured bricks.

PubMed

Scatigno, C; Prieto-Taboada, N; Preite Martinez, M; Conte, A M; Madariaga, J M

2018-06-07

The study of both original and decaying compounds is relevant in understanding the chemistry behind the deterioration processes, above all in open museum contexts where environmental stressors affect the artefacts. In this sense, a combination of non-invasive spectroscopy techniques (Raman spectroscopy, μ-X-ray fluorescence and X-ray diffraction) was applied on an ancient Roman building (130 CE), the "Casa di Diana" Mithraeum at Ostia Antica archaeological site. The aim is to study the raw materials, manufacturing and decaying products of the two observed types of Roman fired bricks (red and yellow) that compose the building. The present study estimates an illite raw material of carbonate-bearing marine clay likely referring to the common deposits of central/southern Italy, which contain calcite as accessory phase and a-plastic fraction constituted by quartz, feldspar and opaques. This clay material was added with volcanic temper characterised by abundant clinopyroxene and analcime (from analcimization of leucite) that are typical of the Roman Province volcanism. The firing would be probably the result of oxidizing conditions, as proved by the hematite presence. Thanks to the existence of specific neoformed mineral phases during firing it was possible to assess different temperatures ranges. In detail, the red/orange bricks, for the existence of gehlenite (formed from calcite and its reaction with silicates), were fired at 800-900 °C range; whereas, the yellow ones are characterised by the lack of gehlenite and the disappearance of illite/muscovite, which indicates firing temperature at over 900 °C. Regarding the decaying products, the gypsum covers most of the surface of most bricks, both red and the yellow ones, but these latter are more susceptible to environmental stressors (sulphates and carbonates). Therefore, this work points out how by integrated non-invasive approaches it is possible trace back to original firing temperature, technology of manufacture, interpreting ceramic data. Copyright © 2018 Elsevier B.V. All rights reserved.

Risk Assessment for Parents Who Suspect Their Child Has Autism Spectrum Disorder: Machine Learning Approach.

PubMed

Ben-Sasson, Ayelet; Robins, Diana L; Yom-Tov, Elad

2018-04-24

Parents are likely to seek Web-based communities to verify their suspicions of autism spectrum disorder markers in their child. Automated tools support human decisions in many domains and could therefore potentially support concerned parents. The objective of this study was to test the feasibility of assessing autism spectrum disorder risk in parental concerns from Web-based sources, using automated text analysis tools and minimal standard questioning. Participants were 115 parents with concerns regarding their child's social-communication development. Children were 16- to 30-months old, and 57.4% (66/115) had a family history of autism spectrum disorder. Parents reported their concerns online, and completed an autism spectrum disorder-specific screener, the Modified Checklist for Autism in Toddlers-Revised, with Follow-up (M-CHAT-R/F), and a broad developmental screener, the Ages and Stages Questionnaire (ASQ). An algorithm predicted autism spectrum disorder risk using a combination of the parent's text and a single screening question, selected by the algorithm to enhance prediction accuracy. Screening measures identified 58% (67/115) to 88% (101/115) of children at risk for autism spectrum disorder. Children with a family history of autism spectrum disorder were 3 times more likely to show autism spectrum disorder risk on screening measures. The prediction of a child's risk on the ASQ or M-CHAT-R was significantly more accurate when predicted from text combined with an M-CHAT-R question selected (automatically) than from the text alone. The frequently automatically selected M-CHAT-R questions that predicted risk were: following a point, make-believe play, and concern about deafness. The internet can be harnessed to prescreen for autism spectrum disorder using parental concerns by administering a few standardized screening questions to augment this process. ©Ayelet Ben-Sasson, Diana L Robins, Elad Yom-Tov. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 24.04.2018.

Every Student Counts: Broadening Participation in the Geosciences through a Multiyear Internship Program

NASA Astrophysics Data System (ADS)

Sloan, V.

2010-12-01

The number of Ph.D.s from underrepresented populations graduating each year in the geosciences lags behind all other sciences including physics. This results in a dearth of minorities acting as role models in higher education. Overall, African Americans, Native Americans, and Hispanics comprised a total of 6% of the Ph.D. graduates in 2005 compared to about 27% of the general population. African Americans were the most poorly represented relative to their proportion in the U.S. population, comprising only 1% of Ph.D.s in the geosciences compared to 12% of the population. Only one African American woman Ph.D. graduated in the geosciences in the U.S. in each of 2004 and 2005, while proportionally one would expect 28 to obtain a Ph.D. each year. Our multiyear internship program, RESESS helps to carry students from underrepresented minority populations through to graduate programs by preparing them for graduate school. Our interns experience an authentic summer research experience at a university, the USGS, or UNAVCO, while doing an intensive writing course and working closely with a science and writing mentor. We continue mentoring during the academic year, as students apply for graduate school and scholarships, and present their research results at professional conferences. RESESS focuses on the Earth sciences and partners with SOARS, which focuses on atmospheric and related sciences. Our future goals include developing more RESESS pods elsewhere in the country, making it possible for students to do community-driven research, and increasing the diversity of support for the program through new and stronger partnerships with organizations such as the U.S.G.S., the National Parks Service, and other universities. In this paper, we will present current statistics on diversity in higher education in the geoscience, details of our program, and conclusions about effective means of supporting minority students in the bridge to graduate school. When the numbers are this low, every student counts. Diana Prado Garzon at work in summer of 2010.

Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1.

PubMed

Xu, Bin; Huang, Yeqing; Niu, Xiaobing; Tao, Tao; Jiang, Liang; Tong, Na; Chen, Shuqiu; Liu, Ning; Zhu, Weidong; Chen, Ming

2015-12-01

MicroRNAs (miRNAs) have been demonstrated playing important roles in the procession of prostate cancer cells transformation from androgen-dependence to androgen-independence. We conducted the miRNA microarray and realtime PCR analyses in both androgen-dependent (ADPC) and androgen-independent prostate cancer (AIPC) tissues. We also explored the role of hsa-miR-146a-5p (miR-146a) in MSKCC prostate cancer clinical database. Moreover, the impact of miR-146a on prostate cancer cells apoptosis were detected by Hoechst staining and fluorescence-activated cell sorter (FACS). Its target is predicted by DIANA LAB online database and the result was assumed by western blotting and luciferase assay. We demonstrated that miR-146a was down-regulated in AIPC tissues and cell lines compared to that in the ADPC tissues. In MSKCC data re-analyses, we found that miR-146a was underexpressed in metastatic prostate cancer tissues and those with Gleason score >8, moreover, low level of miR-146a represented a high biochemical relapse rate after radical prostatectomy. In the functional analyses, we transfected miR-146a mimics into CPRC cell lines and found miR-146a induced cells apoptosis. In mechanic analyses, we found that miR-146a inhibited the basal level of Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) expression by targeting its 3'UTR and an inverse correlation of expression between miR-146a and ROCK1 was observed. Moreover, caspase 3 activity was stimulated by miR-146a overexpression. miR-146a has a critical role in the process of AIPC prostate cancer cells apoptosis through regulation of ROCK/Caspase 3 pathway. Targeting this pathway may be a promising therapeutic strategy for future personalized anti-cancer treatment. © 2015 Wiley Periodicals, Inc.

PREFACE: International Symposium on Ultrasound in the Control of Industrial Processes (UCIP 2012)

NASA Astrophysics Data System (ADS)

Segura, Luis Elvira; Resa López, Pablo; Salazar, Jordi; Benedito Fort, José Javier; Martínez Graullera, Óscar

2012-12-01

The following describes most of the presentations (both oral and poster) given at the International Symposium of Ultrasound in the Control of Industrial Processes (UCIP 2012) celebrated in Madrid between 18 and 20 April 2012. This event was intended to be a meeting point for scientists, engineers and professionals from all over the world in the field of ultrasonics applied to the characterization and control of materials and processes in the industry. More precisely, the topics included were: 1. Novel applications of ultrasound in the industry (including high-power ultrasound) Food science Biotechnology and microbiology Pharmaceutics and cosmetics Petrochemistry and civil engineering 2. New insights in the ultrasonic characterization of media: Fluids and emulsions Nano- and micro-particle dispersions Soft materials Porous bodies and inhomogeneous materials 3. New developments in ultrasonic measuring techniques: Acoustic microscopy Piezoelectric sensors Ultrasonic imaging Signal processing The symposium was organized by the Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND, UPM-CSIC) in collaboration with the Universidad Politécnica de Cataluña, the Universidad Politécnica de Valencia and the University of Leeds. During the conference, 32 posters and 33 oral communications were presented. In addition, 4 invited lectures were imparted: 'Acoustic microscopy, spectroscopy and nanoparticle detection' by Dr Malcolm Povey; 'Acoustic and electroacoustic spectroscopy' by Dr Andrei Dukhin; 'High-Resolution Ultrasonic Spectroscopy and its application for material analysis by Dr Vitaly Buckin; 'Ultrasonic sensors for process applications - state of the art' by Dr Bern Henning; and three tutorials were given: 'PZFlex - Finite Element Analysis for Virtual Prototyping' by Weidlinger Associates; 'SITAU - A flexible architecture controlled by MATLAB for the development of ultrasonic applications' by DASEL; 'Ultra-SCATTERERTM (Acoustics Suite) - The R&D Tool for Multiple Scattering of Generic Waves in Particulate Composites' by Félix Alba Consulting. A total of 93 delegates from 21 countries participated actively in this event, and more than ten companies were involved through oral communications, tutorials, exhibition or sponsorship. Conference photograph Conference photograph Organizers Organizers SCIENTIFIC COMMITTEE Dr Luis Elvira, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Pablo Resa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Oscar F Martinez-Graullera Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Jordi Salazar Department of Electronic Engineering Universitat Politècnica de Catalunya, Spain Dr Jose Benedito Universitat Politècnica de València, Spain ORGANIZING COMMITTEE Dr Luis Elvira, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Prof Malcolm J W Povey, Procter Department of Food Science University of Leeds, United Kingdom Dr Jordi Salazar, Department of Electronic Engineering Universitat Politècnica de Catalunya, Spain Dr Jose Benedito, Universitat Politècnica de València, Spain Dr Oscar F Martinez-Graullera, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Carmen Duran, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Pablo Resa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dra Cristina Aparicio, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Prof Francisco Montero de Espinosa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Jaime Rodríguez-López, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Carlos Sierra, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Shiva Kant Shukla, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Pedro Castro Blazquez, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain David Romero Laorden, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Javier Rodrigo Villazón Terrazas, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Patricia Nevado, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Sofia Aparicio, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Montserrat Parrilla Romero, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Luis Gómez-Ullate Alvear, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Alberto Ibáñez Rodríguez, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Sponsors Sponsors

MURASOC, a parametric model to test climate change effects on soil organic carbon. Application to Southern Spain (Mediterranean áreas)

NASA Astrophysics Data System (ADS)

Parras-Alcántara, Luis; Lozano-García, Beatriz; Brevik, Eric C.; Olaya-Abril, Alfonso; Obregón-Romero, Rafael; Gil Torres, Juan; Recio-Espejo, Jose Manuel

2016-04-01

Soil organic carbon (SOC) is formed through the decomposition processes of plant, animal and microbial residues, root exudates, living and dead microorganism and soil biota; and is the main energy source for soil microorganism. Consequently, a strong feedback is stablished among a large number of components in the complex biota-abiota network. Likewise, SOC influences in physical, chemical and biological soil properties such as temperature, cationic exchange capacity and plant growth (Parras-Alcántara et al., 2015). Therefore, to improve our knowledge about what soil variables are more responsible of SOC content would be extremely useful in soils characterization. In many studies, independent variables were related to SOC, however, the possible combined effects of different independent variables and their ability to model SOC have not been considered. On the other hand, over the last few decades interest in soil organic carbon (SOC) has increased due to its role in C sequestration in terrestrial ecosystems, which could contribute to decreasing atmospheric CO2 levels (Lozano-García et al., 2016; Fernández-Romero et al., 2016; Parras-Alcántara and Lozano-García 2014). Then, attempts to model SOC content have multiplied over this time. In this study, 612 soil profiles obtained from the Natura 2000 network of protected areas in the Sierra Morena mountains, (Spain) were used with the following objectives: i) To quantify SOC content according to different variables (analytical, morphological, genetic and climatic) in order to define the variables that are most closely related to SOC content; ii) To model the Current SOC content for a geographic area (Sierra Morena - Spain); iii) To model SOC suitability-habitat under a climate change scenario; iv) To extrapolate the SOC content and distribution model to the wider Andalusia region, showing the areas that have a high probability to experience an increase in their SOC content in coming years; and v) To propose effective management in Andalusia's soils according to land use and land cover in protected areas of Sierra Morena and the entire Andalusia region. To this aim, 24 independent variables were obtained and, using a correlation and a multiple linear regression analysis (MURASOC), the effects of these variables on the correlation with SOC content were considered. Indeed, predictor analysis was carried out with the best parameters determined with the regression analysis to be used in a climatic change scenario as predictor variables. The main conclusions of this work could be summarize as: i) Direct relationships between environmental variables and SOC content are similar to described by other authors; ii) In a multiple regression analysis, a poor relationship was observed between the analyzed variables and the SOC content; iii) When SOC content is under study, soil organic fraction (and activity) must be taken into consideration; iv) Similar to described by other authors in living entities under a climatic change scenario, a tend to migration of SOC >2% could be observed in latitude and altitude (it tend to disappear in lower altitudes and southern-oriented slopes; and v) The SOC content will decrease in Sierra Morena under a climatic change scenario, but it would increase in Andalusia under ideal conditions. The information generated in this study might support new strategies in decision-making to complete analyses started long ago, and extend it with new biological and biochemical strategies, as for example, identification of microorganism and relationships among them, with the terrestrial ecosystem and with the SOC synthesis and content. Once that is done, it will provide important information for soil management and climate adaptation strategies. REFERENCES Fernández-Romero, M.L., Parras-Alcántara, L., Lozano-García, B., Clark, J.M., Collins, C.D., 2016. Soil quality assessment based on carbon stratification index in different olive grove management practices in Mediterranean areas. Catena 137; 449-458. http://dx.doi.org/10.1016/j.catena.2015.10.019. Lozano-García, B., Parras-Alcántara, L., Brevik, E.C., 2016. Impact of topographic aspect and vegetation (native and reforested areas) on soil organic carbon and nitrogen budgets in Mediterranean natural areas. Science of the Total Environment 544; 963-970. http://dx.doi.org/10.1016/j.scitotenv.2015.12.022. Parras-Alcántara, L., Lozano-García, B., 2014. Conventional tillage versus organic farming in relation to soil organic carbon stock in olive groves in Mediterranean rangelands (southern Spain). Solid Earth, 5; 299-311. http://dx.doi.org/10.5194/se-5-299-2014. Parras-Alcántara, L., Lozano-García, B., Brevik, E.C., Cerdá, A., 2015. Soil organic carbon stocks assessment in Mediterranean natural areas: A comparison of entire soil profiles and soil control sections. Journal of Environmental Management 155; 219-228. http://dx.doi.org/10.1016/j.jenvman.2015.03.039

HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells.

PubMed

Mazzio, Elizabeth A; Soliman, Karam F A

2017-01-02

Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs) are a major epigenetic regulator of transcriptional repression, which are highly overexpressed in advanced malignancy. While original chemotherapy drugs were modeled after phytochemicals elucidated by botanical screenings, HDAC inhibitors (HDACi) such as apicidin, trichostatin A (TSA) and butyrate were discovered as products of fungus and microbes, in particular, gut microbiota. Therefore, a persistent question remains as to the inherent existence of HDACis in raw undigested dietary plant material. In this study, we conduct a high-throughput (HTP) screening of ~1,600 non-fermented commonly used nutraceuticals (spices, herbs, teas, vegetables, fruits, seeds, rinds etc.) at (<600 μg/ml) and food-based polyphenolics (<240 μg/ml) for evidence of HDAC activity inhibition in nuclear HeLa cell lysates. Human HDAC kinetic validation was performed using a standard fluorometric activity assay, followed by an enzymatic-linked immuno-captured ELISA. Both methods were verified using HDACi panel drugs: TSA, apicidin, suberohydroxamic acid, M344, CL-994, valproic acid and sodium phenylbutyrate. The HTP screening was then conducted, followed by a study comparing biological effects of HDACis in HeLa cells, including analysis of whole-transcriptome non-coding RNAs using Affymetrix miRNA 4.1-panel arrays. The HTP screening results confirmed 44/1600 as potential HDACis to which 31 were further eliminated as false-positives. Methodological challenges/concerns are addressed regarding plant product false-positives that arise from the signal reduction of commercial lysine development reagents. Only 13 HDACis were found having an IC 50 under <200 μg/ml: Grapeseed extract (Vitis vinifera), Great burnet root (Sanguisorba Officinalis), Babul (Acacia arabica), Chinese gallnut (Melaphis chinensis), Konaberry extract (Coffea arabica), Uva Ursi (Arctostaphylos uva ursi), Green tea (Camellia sinensis), Meadowsweet (Filipendula ulmaria), Sassafras (Sassafras officinale), Turkey rhubarb (Rheum palmatum), epigallocatechin gallate (EGCG), gossypol and gallic acid. Next, we investigate the biological consequence of HDACi panel drugs in HeLa cells, where the data suggest predominant effects are anti-mitotic rather than cytotoxic. Lastly, differential effects of TSA vs. GSE at sub-lethal concentrations tested on HeLa cells show 6,631 miRNAs expressed in resting cells, 35 significantly up-regulated (TSA) and 81 up-regulated (GSE), with several miRNAs overlapping in the upward direction by both GSE and TSA (e.g. hsa-miR-23b-5p, hsa-miR-27b-5p, hsa-miR-1180-3p, hsa-miR-6880-5p and hsa-mir-943). Using DIANA miRNA online tools, it was determined that GSE and TSA simultaneously cause overexpression of similar miRNAs predicted to destroy the following influential oncogenes: NFkB, NRAS, KRAS, HRAS, MYC, TGFBR1, E2F1, E2F2, BCL21, CDKN1A, CDK6, HIF1a, and VEGFA. The data from this study show that plant- based HDACis are relatively rare, and can elicit a similar pattern to TSA in up-regulating miRNAs involved with tumor suppression of HeLa cervical carcinoma. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Reconstructing dust fluxes and paleoproductivity at the southern Agulhas Plateau since MIS-6

NASA Astrophysics Data System (ADS)

Frenkel, M. M.; Anderson, R. F.; Winckler, G.

2017-12-01

Understanding the mechanisms underlying glacial-interglacial cycles requires characterizing the role of oceanic feedbacks in climatic changes. For example, increased aeolian iron fluxes to Fe-limited regions of the ocean and corresponding changes in marine productivity could have improved biological pump efficiency and resulted in CO2 drawdown. Here we explore these feedbacks using marine sediment core MDO2-2588 collected from the southern Agulhas Plateau (SAP; 41°S, 26°E), located beneath the modern subtropical front. Today, diatom productivity in this region is Si-limited because high Si utilization south of the polar front (PF) means that water advected northward to our study site is Si-depleted. However, previous work has suggested that extended sea ice cover during glacial periods may have limited diatom productivity south of the PF while frontal systems shifted northward, allowing more Si to reach thermocline of the SAP. Meanwhile, increased glacial dust flux to the SAP may have simultaneously supplied more Fe, contributing to higher glacial productivity. This hypothesis has been supported by observations of higher LGM and MIS-6 productivity at MD02-2588 using bulk biogenic content and diatom assemblages (Romero et al., Paleoceanography, 30 (2015) 118-132). Gradients in d13C between benthic and planktic foraminifera have also been used to support Fe fertilization at this site on millennial timescales (Ziegler et al., Nature Geoscience, 6 (2013) 457-461). Yet, studies have yet to produce coordinated records of dust flux and export production for the SAP. Here, we present records of dust, based on 230Th-normalized 232Th fluxes, and export production using 230Th-normalized excess-Ba and opal fluxes and authigenic U through MIS-6. Preliminary results show that lithogenic fluxes to MD02-2588 were approximately twice as high during MIS-6 as MIS-5e and were concurrent with a two-fold increase in excess-Ba flux. However, this relative increase in lithogenic flux during glacials is smaller than the four-fold relative increase in glacial dust flux previously observed in the central South Atlantic (Martínez-García et al., Science, 343 (2014) 1347-1350), motivating future work to study how dust and productivity vary along a zonal transect away from a dust source between glacial and interglacial periods.

Population exposure to heat-related extremes: Demographic change vs climate change

NASA Astrophysics Data System (ADS)

Jones, B.; O'Neill, B. C.; Tebaldi, C.; Oleson, K. W.

2014-12-01

Extreme heat events are projected to increase in frequency and intensity in the coming decades [1]. The physical effects of extreme heat on human populations are well-documented, and anticipating changes in future exposure to extreme heat is a key component of adequate planning/mitigation [2, 3]. Exposure to extreme heat depends not only on changing climate, but also on changes in the size and spatial distribution of the human population. Here we focus on systematically quantifying exposure to extreme heat as a function of both climate and population change. We compare exposure outcomes across multiple global climate and spatial population scenarios, and characterize the relative contributions of each to population exposure to extreme heat. We consider a 2 x 2 matrix of climate and population output, using projections of heat extremes corresponding to RCP 4.5 and RCP 8.5 from the NCAR community land model, and spatial population projections for SSP 3 and SSP 5 from the NCAR spatial population downscaling model. Our primary comparison is across RCPs - exposure outcomes from RCP 4.5 versus RCP 8.5 - paying particular attention to how variation depends on the choice of SSP in terms of aggregate global and regional exposure, as well as the spatial distribution of exposure. We assess how aggregate exposure changes based on the choice of SSP, and which driver is more important, population or climate change (i.e. does that outcome vary more as a result of RCP or SSP). We further decompose the population component to analyze the contributions of total population change, migration, and changes in local spatial structure. Preliminary results from a similar study of the US suggests a four-to-six fold increase in total exposure by the latter half of the 21st century. Changes in population are as important as changes in climate in driving this outcome, and there is regional variation in the relative importance of each. Aggregate population growth, as well as redistribution of the population across larger US regions, strongly affects outcomes while smaller-scale spatial patterns of population change have smaller effects. [1] Collins, M. et al. (2013) Contribution of WG I to the 5th AR of the IPCC[2] Romero-Lankao, P. et al (2014) Contribution of WG II to the 5th AR of the IPCC[3] Walsh, J. et al. (2014) The 3rd National Climate Assessment

Frequency-domain elastic full waveform inversion using encoded simultaneous sources

NASA Astrophysics Data System (ADS)

Jeong, W.; Son, W.; Pyun, S.; Min, D.

2011-12-01

Currently, numerous studies have endeavored to develop robust full waveform inversion and migration algorithms. These processes require enormous computational costs, because of the number of sources in the survey. To avoid this problem, the phase encoding technique for prestack migration was proposed by Romero (2000) and Krebs et al. (2009) proposed the encoded simultaneous-source inversion technique in the time domain. On the other hand, Ben-Hadj-Ali et al. (2011) demonstrated the robustness of the frequency-domain full waveform inversion with simultaneous sources for noisy data changing the source assembling. Although several studies on simultaneous-source inversion tried to estimate P- wave velocity based on the acoustic wave equation, seismic migration and waveform inversion based on the elastic wave equations are required to obtain more reliable subsurface information. In this study, we propose a 2-D frequency-domain elastic full waveform inversion technique using phase encoding methods. In our algorithm, the random phase encoding method is employed to calculate the gradients of the elastic parameters, source signature estimation and the diagonal entries of approximate Hessian matrix. The crosstalk for the estimated source signature and the diagonal entries of approximate Hessian matrix are suppressed with iteration as for the gradients. Our 2-D frequency-domain elastic waveform inversion algorithm is composed using the back-propagation technique and the conjugate-gradient method. Source signature is estimated using the full Newton method. We compare the simultaneous-source inversion with the conventional waveform inversion for synthetic data sets of the Marmousi-2 model. The inverted results obtained by simultaneous sources are comparable to those obtained by individual sources, and source signature is successfully estimated in simultaneous source technique. Comparing the inverted results using the pseudo Hessian matrix with previous inversion results provided by the approximate Hessian matrix, it is noted that the latter are better than the former for deeper parts of the model. This work was financially supported by the Brain Korea 21 project of Energy System Engineering, by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0006155), by the Energy Efficiency & Resources of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Knowledge Economy (No. 2010T100200133).

Snow on the Seafloor? Methods to Detect Carbohydrates in Deep-sea Sediments Impacted by the Deepwater Horizon Oil Spill

NASA Astrophysics Data System (ADS)

Lincoln, S. A.; Freeman, K. H.

2015-12-01

A significant portion of the oil released from the Macondo well after the 2010 Deepwater Horizon (DwH) explosion reached the seafloor (1,2). The transfer of buoyant hydrocarbons from the sea surface and subsurface plumes to depths >1500 m, however, is not well understood. A prominent role for sinking marine snow--small, composite particles composed largely of extracellular polymeric substances exuded by algae and bacteria--has been proposed. Snow particles, rich in carbohydrates, may have sorbed and physically entrained oil from the water column as they sank. Several lines of evidence support this scenario: abundant snow was observed 3-4 weeks after the oil spill (3); oil and dispersants can induce marine snow formation (4); and flocculent material covering deep-sea corals near the DwH site contained biomarkers consistent with Macondo oil (5). To investigate whether the chemically complex marine oil snow leaves a direct sedimentary record, we analyzed carbohydrates at high resolution (2 mm intervals) in sediment cores collected at 4 sites in the northern Gulf of Mexico in 2013 using a modified phenol-sulfuric acid spectrophotometric method. We detected a sharp subsurface peak in carbohydrate concentrations near the Macondo well; we interpret this peak as post-DwH marine snow. Coeval carbohydrate, polycyclic aromatic hydrocarbon, and hopane profiles suggest a clear link between marine snow and Macondo oil components, as documented in a 3-year time-series at one site, and enable preliminary conclusions about the delivery and fate of marine snow components in sediments. We also characterized carbohydrates near the wellhead using fluorescent lectin-binding analyses developed for applications in cell biology. Particle morphologies include collapse structures suggestive of a water column origin. Finally, we explore the extent to which polysaccharide residues detected with selective lectins can be used to determine the provenance of marine snow (e.g., bacterial v. algal). (1) Valentine et al., 2014. PNAS 111, 15906-15911. (2) Romero et al., 2015. PLOS One 10(5): e0128371 (3) Passow et al., ERL 7, 035301. (4) Passow, 2014. Deep-Sea Res. II, http://dx.doi. org/10.1016/j.dsr2.2014.10.001i (5) White et al., 2012. PNAS 109(50), 20303-20308.

PREFACE: XIX Latin American Symposium on Solid State Physics (SLAFES XIX)

NASA Astrophysics Data System (ADS)

Serquis, Adriana; Balseiro, Carlos; Bolcatto, Pablo

2009-07-01

This volume contains selected papers which have been presented at the XIX Latin American Symposium on Solid State Physics (SLAFES XIX) held at Puerto Iguazú, Argentina, from 5--10 October 2008. The conference, covering all areas of Solid State Physics, is one of the most important and traditional meetings in Physics in our region. The Latin American Symposium on Solid State Physics is a forum where researchers and students from Latin America as well as leading scientists from other parts of the world get together to exchange information, strengthen collaborations and identify new challenges in Solid State Physics. This successful series of meetings has been organised in eight different countries, the last three held in Mérida, Venezuela (2002), La Habana, Cuba (2004) and Puebla, México (2006). Following the trends of previous events, SLAFES XIX included seven plenary talks, eighteen invited talks and contributions, and 28 oral and 255 poster presentations, covering mostly the latest experimental and theoretical advances in Nanophysics, Nanomaterials and Nanotechnology, Spintronics, Magnetism, New Materials, Superconductivity, Surfaces and Interfaces, Low-Dimensional Systems, Materials Preparation and Characterization, Theory and Computing Simulations of Materials among other topics. The group of scientists participating had come from Argentina, Chile, Colombia, Cuba, Brazil, France, Spain, Switzerland and the USA We are indebted to all participants for their enthusiasm and contributions and to the members of the International Advisory Commitees. We also wish to thank to the rest of the Organizing Committee: Gustavo Lozano, Ana María Llois, Laura Steren and Edith Goldberg and very specially to Javier Schmidt, Gustavo Ruano, Marcelo Romero, Lucila Cristina and Juan Carlos Moreno for their invaluable assistance during the event. Finally we gratefully aknowledge the financial support the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina, Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), Argentina, Secretaría de Estado de Ciencia, Tecnología e Innovación, Provincia de Santa Fe, Argentina, Centro Latinoamericano de Física (CLAF), Universidad Nacional del Litoral, Santa Fe, Argentina, Institute of Physics (IOP) Publishing, The European Physical Journal (EPJ), EDP Science, Societa Italiana di Fisica and Springer. Adriana Serquis, Carlos Balseiro and Pablo Bolcatto

Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression.

PubMed

Manning, John T; Seregin, Alexey V; Yun, Nadezhda E; Koma, Takaaki; Huang, Cheng; Barral, José; de la Torre, Juan C; Paessler, Slobodan

2017-01-01

Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the Can glycoprotein (GPC) gene is the primary gene responsible for attenuation in a guinea pig model of AHF. However, the mechanisms through which the GPC contributes to the attenuation of the Can strain remain unknown. A more complete understanding of the mechanisms underlying the attenuation and immunogenicity of the Can strain will potentially allow for the rational design of additional safe and novel vaccines. Here, we provide a detailed comparison of both RNA and protein expression profiles between both inter- and intra-segment chimeric JUNV recombinant clones expressing combinations of genes from the Can strain and the pathogenic Romero (Rom) strain. The recombinant viruses that express Can GPC, which were shown to be attenuated in guinea pigs, displayed different RNA levels and GPC processing patterns as determined by Northern and Western blot analyses, respectively. Analysis of recombinant viruses containing amino acid substitutions selected at different mouse brain passages during the generation of Can revealed that altered Can GPC processing was primarily due to the T168A substitution within G1, which eliminates an N-linked glycosylation motif. Incorporation of the T168A substitution in the Rom GPC resulted in a Can-like processing pattern of Rom GPC. In addition, JUNV GPCs containing T168A substitution were retained within the endoplasmic reticulum (ER) and displayed significantly lower cell surface expression than wild-type Rom GPC. Interestingly, the reversion A168T in Can GPC significantly increased GPC expression at the cell surface. Our results demonstrate that recombinant JUNV (rJUNV) expressing Can GPC display markedly different protein expression and elevated genomic RNA expression when compared to viruses expressing Rom GPC. Additionally, our findings indicate that the N-linked glycosylation motif at amino acid positions 166-168 is important for trafficking of JUNV GPC to the cell surface, and the elimination of this motif interferes with the GPC release from the ER.

Approaches to Numerical Relativity

NASA Astrophysics Data System (ADS)

d'Inverno, Ray

2005-07-01

Introduction Ray d'Inverno; Preface C. J. S. Clarke; Part I. Theoretical Approaches: 1. Numerical relativity on a transputer array Ray d'Inverno; 2. Some aspects of the characteristic initial value problem in numerical relativity Nigel Bishop; 3. The characteristic initial value problem in general relativity J. M. Stewart; 4. Algebraic approachs to the characteristic initial value problem in general relativity Jõrg Frauendiener; 5. On hyperboidal hypersurfaces Helmut Friedrich; 6. The initial value problem on null cones J. A. Vickers; 7. Introduction to dual-null dynamics S. A. Hayward; 8. On colliding plane wave space-times J. B. Griffiths; 9. Boundary conditions for the momentum constraint Niall O Murchadha; 10. On the choice of matter model in general relativity A. D. Rendall; 11. A mathematical approach to numerical relativity J. W. Barrett; 12. Making sense of the effects of rotation in general relativity J. C. Miller; 13. Stability of charged boson stars and catastrophe theory Franz E. Schunck, Fjodor V. Kusmartsev and Eckehard W. Mielke; Part II. Practical Approaches: 14. Numerical asymptotics R. Gómez and J. Winicour; 15. Instabilities in rapidly rotating polytropes Scott C. Smith and Joan M. Centrella; 16. Gravitational radiation from coalescing binary neutron stars Ken-Ichi Oohara and Takashi Nakamura; 17. 'Critical' behaviour in massless scalar field collapse M. W. Choptuik; 18. Goudunov-type methods applied to general relativistic gravitational collapse José Ma. Ibánez, José Ma. Martí, Juan A. Miralles and J. V. Romero; 19. Astrophysical sources of gravitational waves and neutrinos Silvano Bonazzola, Eric Gourgoulhon, Pawel Haensel and Jean-Alain Marck; 20. Gravitational radiation from triaxial core collapse Jean-Alain Marck and Silvano Bonazzola; 21. A vacuum fully relativistic 3D numerical code C. Bona and J. Massó; 22. Solution of elliptic equations in numerical relativity using multiquadrics M. R. Dubal, S. R. Oliveira and R. A. Matzner; 23. Self-gravitating thin disks around rotating black holes A. Lanza; 24. An ADI and causal reconnection Gabrielle D. Allen and Bernard F. Schutz; 25. Time-symmetric ADI and causal reconnection Miguel Alcubierre and Bernard F. Schutz; 26. The numerical study of topological defects E. P. S. Shellard; 27. Computations of bubble growth during the cosmological quark-hadron transition J. C. Miller and O. Pantano; 28. Initial data of axisymmetric gravitational waves with a cosmological constant Ken-Ichi Nakao, Kei-Ichi Maeda, Takashi Nakamura and Ken-Ichi Oohara.

Supply and Demand in mHealth Apps for Persons With Multiple Sclerosis: Systematic Search in App Stores and Scoping Literature Review.

PubMed

Giunti, Guido; Guisado Fernández, Estefanía; Dorronzoro Zubiete, Enrique; Rivera Romero, Octavio

2018-05-23

Multiple sclerosis (MS) is a non-curable chronic inflammatory disease of the central nervous system that affects more than 2 million people worldwide. MS-related symptoms impact negatively on the quality of life of persons with MS, who need to be active in the management of their health. mHealth apps could support these patient groups by offering useful tools, providing reliable information, and monitoring symptoms. A previous study from this group identified needs, barriers, and facilitators for the use of mHealth solutions among persons with MS. It is unknown how commercially available health apps meet these needs. The main objective of this review was to assess how the features present in MS apps meet the reported needs of persons with MS. We followed a combination of scoping review methodology and systematic assessment of features and content of mHealth apps. A search strategy was defined for the two most popular app stores (Google Play and Apple App Store) to identify relevant apps. Reviewers independently conducted a screening process to filter apps according to the selection criteria. Interrater reliability was assessed through the Fleiss-Cohen coefficient (k=.885). Data from the included MS apps were extracted and explored according to classification criteria. An initial total of 581 potentially relevant apps was found. After removing duplicates and applying inclusion and exclusion criteria, 30 unique apps were included in the study. A similar number of apps was found in both stores. The majority of the apps dealt with disease management and disease and treatment information. Most apps were developed by small and medium-sized enterprises, followed by pharmaceutical companies. Patient education and personal data management were among the most frequently included features in these apps. Energy management and remote monitoring were often not present in MS apps. Very few contained gamification elements. Currently available MS apps fail to meet the needs and demands of persons with MS. There is a need for health professionals, researchers, and industry partners to collaborate in the design of mHealth solutions for persons with MS to increase adoption and engagement. ©Guido Giunti, Estefanía Guisado Fernández, Enrique Dorronzoro Zubiete, Octavio Rivera Romero. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 23.05.2018.

Camões e a cosmogonia

NASA Astrophysics Data System (ADS)

Costa, J. M.

2003-08-01

Os Lusíadas, escrito por Luis de Camões em 1572, é um poema épico renascentista e a visão Cosmogônica do autor é apresentada, principalmente, no último canto do poema, quando Tétis mostra ao Gama a Máquina do Mundo. A Cosmogonia de Camões neste poema reflete uma visão de uma época de transição, que ainda não incorporou os elementos da revolução Copernicana. É uma visão Grego- Ptolomaica e também medieval. O poeta guia-se pela tradução e notas feita por Pedro Nunes, inventor do Nonio, do Tratado da Esfera "De Sphaera" do Astrônomo Inglês John Holywood, mais conhecido pelo nome latinizado de Johannes Sacrobosco. Outra provável fonte de Camões, de acordo com Luciano Antonio Pereira da Silva em Astronomia de os Lusíadas, é o "Theoricae novae Planetarum" (1460) do astrólogo Alemão Jorge Purbáquio (1423 - 1461). A Astronomia de Os Lusíadas representa a ciência do tempo de Camões. Camões nunca emprega a palavra constelação e seu catálogo é bastante completo. A Máquina do Mundo tem a Terra no centro. Em redor, em círculos concêntricos, a lua (Diana), Mercúrio, Vênus, o Sol (Febo), Marte, Júpiter e Saturno. Envolvendo estes astros tem o firmamento seguido pelo "Céu Áqueo" ou cristalino, depois o 1o Móbil, esfera que arrasta todas as outras consigo. Este trabalho, multidisciplinar, serve tanto para ensinar aos alunos da Física como das Ciências Humanas, a concepção de mundo do renascimento de uma forma belamente poética em versos decassílabos Este trabalho também ajuda na apreciação do maior clássico da língua portuguesa e mostra como as Ciências e as artes, em geral, estão correlacionadas e refletem a visão de mundo da época em que foi produzida.

Patients' Need for Tailored Comparative Health Care Information: A Qualitative Study on Choosing a Hospital.

PubMed

Zwijnenberg, Nicolien C; Hendriks, Michelle; Bloemendal, Evelien; Damman, Olga C; de Jong, Judith D; Delnoij, Diana Mj; Rademakers, Jany Jd

2016-11-28

The Internet is increasingly being used to provide patients with information about the quality of care of different health care providers. Although online comparative health care information is widely available internationally, and patients have been shown to be interested in this information, its effect on patients' decision making is still limited. This study aimed to explore patients' preferences regarding information presentation and their values concerning tailored comparative health care information. Meeting patients' information presentation needs might increase the perceived relevance and use of the information. A total of 38 people participated in 4 focus groups. Comparative health care information about hip and knee replacement surgery was used as a case example. One part of the interview focused on patients' information presentation preferences, whereas the other part focused on patients' values of tailored information (ie, showing reviews of patients with comparable demographics). The qualitative data were transcribed verbatim and analyzed using the constant comparative method. The following themes were deduced from the transcripts: number of health care providers to be presented, order in which providers are presented, relevancy of tailoring patient reviews, and concerns about tailoring. Participants' preferences differed concerning how many and in which order health care providers must be presented. Most participants had no interest in patient reviews that were shown for specific subgroups based on age, gender, or ethnicity. Concerns of tailoring were related to the representativeness of results and the complexity of information. A need for information about the medical specialist when choosing a hospital was stressed by several participants. The preferences for how comparative health care information should be presented differ between people. "Information on demand" and information about the medical specialist might be promising ways to increase the relevancy and use of online comparative health care information. Future research should focus on how different groups of people use comparative health care information for different health care choices in real life. ©Nicolien C Zwijnenberg, Michelle Hendriks, Evelien Bloemendal, Olga C Damman, Judith D de Jong, Diana MJ Delnoij, Jany JD Rademakers. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 28.11.2016.

On the seismic behavior of the main tower of the San Felice sul Panaro (Italy) fortress

NASA Astrophysics Data System (ADS)

Castellazzi, Giovanni; D'Altri, Antonio Maria; de Miranda, Stefano; Magagnini, Stefano; Tralli, Antonio

2016-12-01

The medieval fortresses are a very common and distinctive type among the Emilian historical constructions and the earthquakes of May 20th and 29th, 2012 underlined their high vulnerability. Among those heavily damaged, there is the fortress of San Felice sul Panaro located between the two epicenters. This study presents some FE results regarding the behavior under seismic actions of the main tower (Mastio tower). The Mastio has peculiar geometric features and represents a typical example of non-isolated tower. In fact, it is constrained in very different ways by the surrounding parts of the fortress along two of its sides: on the north side it is constrained by the perimeter wall until one third of his high, while a stiffer building constrains it on the west side. In order to remodel the entire fortress, a multidisciplinary project involving the Municipality of San Felice sul Panaro and four Universities of the Emilia- Romagna (Bologna, Ferrara, Parma and Modena) together with the University of Genoa is going on. The study, oriented to the structural restoration, produced an accurate survey of the entire building including a fine definition of architectural peculiarities, historical stages and materials evolution. Based on such geometrical data, we developed a detailed 3D realistic mesh, with a point-by-point characterization of each single geometric element. We performed both pushover and nonlinear dynamic analyses using accelerograms data measured near the fortress on May 29th. A damage-plasticity material model exhibiting softening in both tension and compression, already available in the commercial code Abaqus, has been used for masonry in nonlinear dynamic analyses. On the other hand, pushover analyses have been performed utilizing similar constitutive equations available on code DIANA. The effects of higher modes of vibration have been taken into account by means of the modal pushover analysis technique. For the sake of conciseness, only some preliminary findings are presented in this paper. The results obtained with pushover analyses fit reasonably well with nonlinear dynamic simulations.

PREFACE: FAIRNESS 2013: FAIR NExt generation of ScientistS 2013

NASA Astrophysics Data System (ADS)

Petersen, Hannah; Destefanis, Marco; Galatyuk, Tetyana; Montes, Fernando; Nicmorus, Diana; Ratti, Claudia; Tolos, Laura; Vogel, Sascha

2014-04-01

FAIRNESS 2013 was the second edition in a series of workshops designed to bring together excellent international young scientists with research interests focused on physics at FAIR (Facility for Antiproton and Ion Research) and was held on 16-21 September 2013 in Berlin, Germany. The topics of the workshop cover a wide range of aspects in both theoretical developments and current experimental status, concentrated around the four scientific pillars of FAIR. FAIR is a new accelerator complex with brand new experimental facilities, that is currently being built next to the existing GSI Helmholtzzentrum for Schwerionenforschung close to Darmstadt, Germany. The spirit of the conference is to bring together young scientists, e.g. advanced PhD students and postdocs and young researchers without permanent position to present their work, to foster active informal discussions and build up of networks. Every participant in the meeting with the exception of the organizers gives an oral presentation, and all sessions are followed by an hour long discussion period. During the talks, questions are anonymously collected in box to stimulate discussions. Since the physics program of FAIR is very broad, this is reflected in the wide range of topics covered at the Conference: Physics of hot and dense nuclear matter, QCD phase transitions and critical point Nuclear structure, astrophysics and reactions Hadron spectroscopy, Hadrons in matter and Hypernuclei Special emphasis is put on the experiments CBM, HADES, PANDA, NuSTAR, as well as NICA and the RHIC low beam energy scan New developments in atomic and plasma physics For all of these different areas one invited speaker was selected to give a longer introductory presentation. The write-ups of the talks presented at FAIRNESS 2013 are the content of this issue of Journal of Physics: Conference Series and have been refereed according to the IOP standard for peer review. This issue constitutes therefore a collection of the forefront of research that is dedicated to the physics of FAIR. February 2014. Organizers of FAIRNESS 2013: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Logos

Detección de Treponema pallidum subespecie pallidum para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa anidada.

PubMed

Pinilla, Gladys; Campos, Lesly; Durán, Andrea; Navarrete, Jeannette; Muñoz, Liliana

2018-03-15

Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas.Materiales y métodos. Mediante PCR convencional y anidada, se amplificaron tres genes diana (polA, 16S ADNr y TpN47) y se confirmaron los productos de amplificación de los genes TpN47 y polA por secuenciación. Las pruebas serológicas empleadas fueron la VDRL (Venereal Disease Research Laboratory), la de reagina plasmática rápida (Rapid Plasma Reagin, RPR) y la de aglutinación de partículas para Treponema pallidum (Treponema pallidum Particle Agglutination Assay, TPPA).Resultados. La sensibilidad para la PCR convencional fue de 52 pg y, para la PCR anidada, de 0,52 pg. La especificidad con los iniciadores TpN47 y polA fue de 100 %; los resultados de la secuenciación mostraron una identidad de 97 % con T. pallidum. En 70 % de las muestras, los resultados de las pruebas serológicas y la PCR anidada concordaron.Conclusión. El gen TpN47 resultó ser el mejor blanco molecular para la identificación de T. pallidum. La PCR anidada se presenta como una alternativa de diagnóstico molecular promisoria para el diagnóstico de sífilis congénita.

Geologic Mapping of Isabella Quadrangle (V-50) and Helen Planitia, Venus

NASA Technical Reports Server (NTRS)

Bleamaster, Leslie F., III

2008-01-01

(25-50 S, 180-210 E) is host to numerous coronae and small volcanic centers (paterae and shield fields), focused (Aditi and Sirona Dorsa) and distributed (penetrative north-south trending wrinkle ridges) contractional deformation, and radial and linear extensional structures, all of which contribute materials to and/or deform the expansive surrounding plains (Nsomeka and Wawalag Planitiae). Regional plains, which are a northern extension of regional plains mapped in the Barrymore Quadrangle V-59 [1], dominate the V-50 quadrangle. Previous mapping divided the regional plains into two members: regional plains, members a and b [2]. A re-evaluation of these members has determined that a continuous and consistent unit contact does not exist; however, the majority of this radar unit or surficial unit will still be displayed on the final map as a stipple pattern as it is a prevalent feature of the quadrangle. With minimal tessera or highland material, much of the quadrangle s oldest materials are plains units (the regional plains). Much of these plains are covered with small shield edifices that exhibit a variety of material contributions (or flows). In the northwest, several flows emerge and flow to the southeast from Diana-Dali Chasmata. Local corona- and mons-fed flows superpose the regional plains; however, earlier stages of volcano-tectonic centers marked by arcuate and radial structural elements, including terrain so heavily deformed that it takes on a new appearance, may have developed prior to or concurrently with the region plains. Northtrending deformation belts disrupt the central portion of the map area and wrinkle ridges parallel these larger belts. Isabella crater, in the northeastern quadrant, is highly asymmetric and displays two prominent ejecta blanket morphologies, which generally correlate with distance from the impact structure suggesting that ejecta block size or ejecta blanket thickness may be the cause. The crater floor is very dark and shows no direct connection with the large outflow to the south, which emphasizes the asymmetry observed. Isabella crater ejecta and outflow materials clearly postdate several small craters in the vicinity.

PREFACE: FAIRNESS 2014: FAIR Next Generation ScientistS 2014

NASA Astrophysics Data System (ADS)

2015-04-01

FAIRNESS 2014 was the third edition in a series of workshops designed to bring together excellent international young scientists with research interests focused on physics at FAIR (Facility for Antiproton and Ion Research) and was held on September 22-27 2014 in Vietri sul Mare, Italy. The topics of the workshops cover a wide range of aspects in both theoretical developments and current experimental status, concentrated around the four scientific pillars of FAIR. FAIR is a new accelerator complex with brand new experimental facilities, that is currently being built next to the existing GSI Helmholtzzentrum for Schwerionenforschung close to Darmstadt, Germany. The spirit of the conference is to bring together young scientists, e.g. advanced PhD students and postdocs and young researchers without permanent position to present their work, to foster active informal discussions and build up of networks. Every participant in the meeting with the exception of the organizers gives an oral presentation, and all sessions are followed by an hour long discussion period. During the talks, questions are anonymously collected in a box to stimulate discussions. The broad physics program at FAIR is reflected in the wide range of topics covered by the workshop: • Physics of hot and dense nuclear matter, QCD phase transitions and critical point • Nuclear structure, astrophysics and reactions • Hadron Spectroscopy, Hadrons in matter and Hypernuclei • New developments in atomic and plasma physics • Special emphasis is put on the experiments CBM, HADES, PANDA, NUSTAR, APPA and related experiments For each of these different areas one invited speaker was selected to give a longer introductory presentation. The write-ups of the talks presented at FAIRNESS 2014 are the content of this issue of Journal of Physics: Conference Series and have been refereed according to the IOP standard for peer review. This issue constitutes therefore a collection of the forefront of research that is dedicated to the physics at FAIR. February 2015, Organizers of FAIRNESS 2014: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Conference photograph

Conference Comments by the Editors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archer, Daniel E

2009-01-01

The Symposium on Radiation Measurements and Applications (SORMA) met for the first time on the West Coast June 2-5, 2008, in Berkeley, CA. With radiation detectors increasing in number, variety, and societal importance, we plan to alternate between SORMA East (in Ann Arbor, MI) and SORMA West so that the forum will be available every two years. The topic areas for SORMA West 2008 were much the same as those of recent Ann Arbor programs, and were meant to encompass the full breadth of ionizing radiation measurement applications and technologies, with both oral and poster presentations. The technical program ofmore » SORMA 2008 included 342 scientific presentations, 116 oral presentations plus eight invited keynote lectures in plenary sessions, as well as 218 presentations in poster sessions. The SORMA 2008 meetings were attended by 439 registered participants from 25 different countries. Topics of interest at the meeting ranged from room temperature semiconductor detectors, cryogenic detectors, photodetectors, neutron detectors, novel scintillators, nonproportionality and characterization of scintillators, simulation and analysis of radiation interactions, novel radiation sources, imaging technologies and homeland security and medical applications. This was the first conference of the SORMA series to be technically cosponsored by the Institute of Electrical and Electronic Engineers (IEEE), specifically by the Nuclear and Plasma Sciences Society (NPSS) of IEEE. The co-sponsorship has been important for visibility of SORMA and for attracting a record number of new participants. This special issue of IEEE TRANSACTIONS ON NUCLEAR SCIENCE comprises the refereed proceedings of SORMA 2008, containing 128 papers on the research presentations. The Chairs of the SORMA 2008 conference would like to acknowledge partial financial support from the NNSA, DNDO, and DTRA, and organizational support from Lawrence Berkeley National Laboratory and Lawrence Livermore National Laboratory. We acknowledge our corporate supporters: Caen Nuclear, Eljen Technology, Hilger Crystals and GE Global Research. Finally, we thank the members of the local organizing committee: Diana Attila, Thomas Budinger, Joe Chew, Daniel Chivers, Rob Johnson, Laurie O'Brien, Donna Raziano, Emily Sause, and Brian Wirth for doing all the work that actually made this conference happen.« less

Effect of fire-induced damage on the uniaxial strength characteristics of solid timber: A numerical study

NASA Astrophysics Data System (ADS)

Hopkin, D. J.; El-Rimawi, J.; Lennon, T.; Silberschmidt, V. V.

2011-07-01

The advent of the structural Eurocodes has allowed civil engineers to be more creative in the design of structures exposed to fire. Rather than rely upon regulatory guidance and prescriptive methods engineers are now able to use such codes to design buildings on the basis of credible design fires rather than accepted unrealistic standard-fire time-temperature curves. Through this process safer and more efficient structural designs are achievable. The key development in enabling performance-based fire design is the emergence of validated numerical models capable of predicting the mechanical response of a whole building or sub-assemblies at elevated temperature. In such a way, efficiency savings have been achieved in the design of steel, concrete and composite structures. However, at present, due to a combination of limited fundamental research and restrictions in the UK National Annex to the timber Eurocode, the design of fire-exposed timber structures using numerical modelling techniques is not generally undertaken. The 'fire design' of timber structures is covered in Eurocode 5 part 1.2 (EN 1995-1-2). In this code there is an advanced calculation annex (Annex B) intended to facilitate the implementation of numerical models in the design of fire-exposed timber structures. The properties contained in the code can, at present, only be applied to standard-fire exposure conditions. This is due to existing limitations related to the available thermal properties which are only valid for standard fire exposure. In an attempt to overcome this barrier the authors have proposed a 'modified conductivity model' (MCM) for determining the temperature of timber structural elements during the heating phase of non-standard fires. This is briefly outlined in this paper. In addition, in a further study, the MCM has been implemented in a coupled thermo-mechanical analysis of uniaxially loaded timber elements exposed to non-standard fires. The finite element package DIANA was adopted with plane-strain elements assuming two-dimensional heat flow. The resulting predictions of failure time for given levels of load are discussed and compared with the simplified 'effective cross section' method presented in EN 1995-1-2.

PREFACE: FAIRNESS 2012: FAIR NExt Generation of ScientistS 2012

NASA Astrophysics Data System (ADS)

Arcones, Almudena; Bleicher, Marcus; Fritsch, Miriam; Galatyuk, Tetyana; Nicmorus, Diana; Petersen, Hannah; Ratti, Claudia; Tolos, Laura

2013-03-01

FAIRNESS 2012 was the first in a series of workshops designed to bring together excellent international young scientists with research interests focused on physics at FAIR (Facility for Antiproton and Ion Research) and was held on 3-8 September 2012 in Hersonissos, Greece. The workshop covered a wide range of topics, both theoretical developments and current experimental status, that concentrated around the four scientific pillars of FAIR. FAIR is a new accelerator complex with brand new experimental facilities, that is currently being built next to the existing Helmholtzzentrum for Schwerionenforschung close to Darmstadt, Germany. The spirit of the conference was to bring together young scientists, e.g. advanced PhD students and postdocs and young researchers without permament position to present their work and to foster active informal discussions and the build-up of networks. Every participant at the meeting, with the exception of the organizers, gave an oral presentation and all sessions were followed by an hour long discussion period. During the talks questions were collected anonymously in a circulating box to stimulate these discussions. Since the physics program of FAIR is very broad, this was reflected in the wide range of topics covered at the conference: Physics of hot and dense nuclear matter, QCD phase transitions and critical point Nuclear structure, astrophysics and reactions Hadron Spectroscopy, Hadrons in matter and Hypernuclei Special emphasis is put on the experiments CBM, HADES, PANDA, NuSTAR, as well as NICA and the RHIC low beam energy scan New developments in atomic and plasma physics In each of these different areas one invited speaker was selected to give a longer introductory presentation. The write-ups of the talks presented at FAIRNESS 2012 are the content of this issue of Journal of Physics: Conference Series and have been refereed according to the IOP standard for peer review. This issue constitutes therefore a collection of the forefront of research that is dedicated to the physics of FAIR. February 2013, Organizers of FAIRNESS 2012: Almudena Arcones, Marcus Bleicher, Miriam Fritsch, Tetyana Galatyuk, Diana Nicmorus, Hannah Petersen, Claudia Ratti and Laura Tolos Support for holding the conference was provided by: logos

How do soil properties and soil carbon stocks change after land abandonment in Mediterranean mountain areas?

NASA Astrophysics Data System (ADS)

Nadal Romero, Estela; Cammeraat, Erik; Pérez Cardiel, Estela; Lasanta, Teodoro

2016-04-01

Land abandonment and subsequent revegetation processes (due to secondary succession and afforestation practices) are global issues with important implications in Mediterranean mountain areas. Moreover, the effects of land use changes on soil carbon stocks are a matter of concern stated in international policy agendas on the mitigation of greenhouse emissions, and afforestation practices are increasingly viewed as an environmental restorative land use change prescription and are considered one of the most efficient carbon sequestration strategies currently available. The MED-AFFOREST project aims to gain more insight into the discussion by exploring the following central research questions: (i) what is the impact of land abandonment on soil properties? and (ii) how do soil organic carbon change after land abandonment? The main objective of this study is to assess the effects of land abandonment, land use change and afforestation practices on soil properties and soil organic carbon (SOC) dynamics. For this aim, five different land covers (bare soil, meadows, secondary succession, Pinus sylvestris (PS) and Pinus nigra (PN) afforestation), in the Central Spanish Pyrenees were analysed. Results showed that changes in soil properties after land abandonment were limited, even if afforestation practices were carried out and no differences were observed between natural succession and afforestation. The results on SOC dynamics showed that: (i) SOC contents were higher in the PN sites in the topsoil (10 cm), (ii) when all the profile was considered no significant differences were observed between meadows and PN, (iii) SOC accumulation under secondary succession is a slow process, and (iv) meadows should also be considered due to the relative importance in SOC stocks. The first step of SOC stabilization after afforestation is the formation of macro-aggregates promoted by large inputs of SOC, with a high contribution of labile organic matter. However, our respiration experiments did not show evidence of SOC stabilization. SOC mineralization was higher in the top layers and values decreased with depth. These results put the question forward which type of forest and landscape management is most appropriate to decide for the best practices after land abandonment for soil recovery and soil organic carbon dynamics. Acknowledgments This research was supported by a Marie Curie Intra-European Fellowship in the project "MED-AFFOREST" (PIEF-GA-2013-624974). E. Nadal-Romero was the recipient of a "Ramón y Cajal" postdoctoral contract (Spanish Ministry of Economy and Competitiveness).

Identification of miRNAs during mouse postnatal ovarian development and superovulation.

PubMed

Khan, Hamid Ali; Zhao, Yi; Wang, Li; Li, Qian; Du, Yu-Ai; Dan, Yi; Huo, Li-Jun

2015-07-08

MicroRNAs are small noncoding RNAs that play critical roles in regulation of gene expression in wide array of tissues including the ovary through sequence complementarity at post-transcriptional level. Tight regulation of multitude of genes involved in ovarian development and folliculogenesis could be regulated at transcription level by these miRNAs. Therefore, tissue specific miRNAs identification is considered a key step towards understanding the role of miRNAs in biological processes. To investigate the role of microRNAs during ovarian development and folliculogenesis we sequenced eight different libraries using Illumina deep sequencing technology. Different developmental stages were selected to explore miRNAs expression pattern at different stages of gonadal maturation with/without treatment of PMSG/hCG for superovulation. From massive sequencing reads, clean reads of 16-26 bp were selected for further analysis of differential expression analysis and novel microRNA annotation. Expression analysis of all miRNAs at different developmental stages showed that some miRNAs were present ubiquitously while others were differentially expressed at different stages. Among differentially expressed miRNAs we reported 61 miRNAs with a fold change of more than 2 at different developmental stages among all libraries. Among the up-regulated miRNAs, mmu-mir-1298 had the highest fold change with 4.025 while mmu-mir-150 was down-regulated more than 3 fold. Furthermore, we found 2659 target genes for 20 differentially expressed microRNAs using seven different target predictions programs (DIANA-mT, miRanda, miRDB, miRWalk, RNAhybrid, PICTAR5, TargetScan). Analysis of the predicted targets showed certain ovary specific genes targeted by single or multiple microRNAs. Furthermore, pathway annotation and Gene ontology showed involvement of these microRNAs in basic cellular process. These results suggest the presence of different miRNAs at different stages of ovarian development and superovulation. Potential role of these microRNAs was elucidated using bioinformatics tools in regulation of different pathways, biological functions and cellular components underlying ovarian development and superovulation. These results provide a framework for extended analysis of miRNAs and their roles during ovarian development and superovulation. Furthermore, this study provides a base for characterization of individual miRNAs to discover their role in ovarian development and female fertility.

High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model

PubMed Central

Kong, Yan; Liang, Xijun; Liu, Lin; Zhang, Dongdong; Wan, Chao; Gan, Zhenji; Yuan, Liudi

2015-01-01

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with pathological features including death of dopaminergic neurons in the substantia nigra and intraneuronal accumulations of Lewy bodies. As the main component of Lewy bodies, α-synuclein is implicated in PD pathogenesis by aggregation into insoluble filaments. However, the detailed mechanisms underlying α-synuclein induced neurotoxicity in PD are still elusive. MicroRNAs are ~20nt small RNA molecules that fine-tune gene expression at posttranscriptional level. A plethora of miRNAs have been found to be dysregulated in the brain and blood cells of PD patients. Nevertheless, the detailed mechanisms and their in vivo functions in PD still need further investigation. By using Drosophila PD model expressing α-synuclein A30P, we examined brain miRNA expression with high-throughput small RNA sequencing technology. We found that five miRNAs (dme-miR-133-3p, dme-miR-137-3p, dme-miR-13b-3p, dme-miR-932-5p, dme-miR-1008-5p) were upregulated in PD flies. Among them, miR-13b, miR-133, miR-137 are brain enriched and highly conserved from Drosophila to humans. KEGG pathway analysis using DIANA miR-Path demonstrated that neuroactive-ligand receptor interaction pathway was most likely affected by these miRNAs. Interestingly, miR-137 was predicted to regulate most of the identified targets in this pathway, including dopamine receptor (DopR, D2R), γ-aminobutyric acid (GABA) receptor (GABA-B-R1, GABA-B-R3) and N-methyl-D-aspartate (NMDA) receptor (Nmdar2). The validation experiments showed that the expression of miR-137 and its targets was negatively correlated in PD flies. Further experiments using luciferase reporter assay confirmed that miR-137 could act on specific sites in 3’ UTR region of D2R, Nmdar2 and GABA-B-R3, which downregulated significantly in PD flies. Collectively, our findings indicate that α-synuclein could induce the dysregulation of miRNAs, which target neuroactive ligand-receptor interaction pathway in vivo. We believe it will help us further understand the contribution of miRNAs to α-synuclein neurotoxicity and provide new insights into the pathogenesis driving PD. PMID:26361355

High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.

PubMed

Kong, Yan; Liang, Xijun; Liu, Lin; Zhang, Dongdong; Wan, Chao; Gan, Zhenji; Yuan, Liudi

2015-01-01

Parkinson's disease (PD) is a prevalent neurodegenerative disorder with pathological features including death of dopaminergic neurons in the substantia nigra and intraneuronal accumulations of Lewy bodies. As the main component of Lewy bodies, α-synuclein is implicated in PD pathogenesis by aggregation into insoluble filaments. However, the detailed mechanisms underlying α-synuclein induced neurotoxicity in PD are still elusive. MicroRNAs are ~20nt small RNA molecules that fine-tune gene expression at posttranscriptional level. A plethora of miRNAs have been found to be dysregulated in the brain and blood cells of PD patients. Nevertheless, the detailed mechanisms and their in vivo functions in PD still need further investigation. By using Drosophila PD model expressing α-synuclein A30P, we examined brain miRNA expression with high-throughput small RNA sequencing technology. We found that five miRNAs (dme-miR-133-3p, dme-miR-137-3p, dme-miR-13b-3p, dme-miR-932-5p, dme-miR-1008-5p) were upregulated in PD flies. Among them, miR-13b, miR-133, miR-137 are brain enriched and highly conserved from Drosophila to humans. KEGG pathway analysis using DIANA miR-Path demonstrated that neuroactive-ligand receptor interaction pathway was most likely affected by these miRNAs. Interestingly, miR-137 was predicted to regulate most of the identified targets in this pathway, including dopamine receptor (DopR, D2R), γ-aminobutyric acid (GABA) receptor (GABA-B-R1, GABA-B-R3) and N-methyl-D-aspartate (NMDA) receptor (Nmdar2). The validation experiments showed that the expression of miR-137 and its targets was negatively correlated in PD flies. Further experiments using luciferase reporter assay confirmed that miR-137 could act on specific sites in 3' UTR region of D2R, Nmdar2 and GABA-B-R3, which downregulated significantly in PD flies. Collectively, our findings indicate that α-synuclein could induce the dysregulation of miRNAs, which target neuroactive ligand-receptor interaction pathway in vivo. We believe it will help us further understand the contribution of miRNAs to α-synuclein neurotoxicity and provide new insights into the pathogenesis driving PD.

Near-Infrared Hyperspectral Image Cubes of Mars during the 1999 Opposition

NASA Technical Reports Server (NTRS)

Hillman, John J.; Glenar, D.; Espenak, F.; Chanover, N.; Murphy, J.; Young, L.; Blass, W.

1999-01-01

We used the Goddard Space Flight Center, Acousto-Optic Tunable Filter (AOTF) Camera to obtain near-IR spectral image sets of Mars over the 1.6-3.6 micron region during the April 1999 opposition. A complete image set consists of 280 images with a spectral full-width-half maximum of 10 wavenumbers (fixed in frequency), 90 images in H-band (1.55-1.80 micron), 115 images in K-band (1.95-2.50 micron) and 75 images in L-band (2.90-3.70 micron). The short-wavelength limit is set by transmission of AOTF cell and long-wavelength limit is imposed by sensitivity of PICNIC, 256x256, HgCdTe array detector. We will discuss the new array performance and provide preliminary interpretations of some of these results. These measurements were part of a 4-observatory coordinated effort whose overall objective was to assemble a photometrically calibrated, spectrally complete ground-based image cube over the visible and near-IR spectral region. To accomplish this, four observing teams conducted the investigations with instruments spanning 0.4 to 5.0 micron. The instruments and observing facilities were (a) AOTF camera at Apache Point Observatory, 3.5m, f/10, Nasymth focus (this abstract). Primary science targets included the 3 micron water-of hydration feature and CO2, H2O ice (polar regions and clouds); (b) Visible/NIR interference-filter (24 filters) camera at Lowell Observatory, 72" telescope. 430-1050 nm. Science targets were Fe(2+), Fe(3+) mineralogy and coarse grain hematite search; (c) NMSU Tortugas Mountain Observatory, 60 cm telescope, CCD photometry with same filter set as Lowell; (d) KPNO cryogenic grating/slit spectrometer (CRSP/SALLY) at KPNO 2.1 m, f/15 Cassegrain focus (see abstract by D. Glenar, et. al., this meeting). Selected wavelengths in 3-5 micron region (L, M band). Science targets included water-of-hydration feature (3-4 micron long wave extension) and sulfate mineralogy. Observers participating in this campaign included Dave Glenar, John Hillman, Gordon Bjoraker and Fred Espenak from GSFC, Nancy Chanover, Jim Murphy and A. S. MurTell from NMSU, Leslie Young from BU, Diana Blaney from JPL and Dick Joyce from KPNO.

MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma.

PubMed

Pereira, Thaís Dos Santos Fontes; Brito, João Artur Ricieri; Guimarães, André Luiz Sena; Gomes, Carolina Cavaliéri; de Lacerda, Júlio Cesar Tanos; de Castro, Wagner Henriques; Coimbra, Roney Santos; Diniz, Marina Gonçalves; Gomez, Ricardo Santiago

2018-01-01

Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis. Nine COF and ten normal bone samples were included in the study. miRNA profiling was carried out by using TaqMan® OpenArray® Human microRNA panel containing 754 validated human miRNAs. We identified the most relevant miRNAs target genes through the leader gene approach, using STRING and Cytoscape software. Pathways enrichment analysis was performed using DIANA-miRPath. Eleven miRNAs were downregulated (hsa-miR-95-3p, hsa-miR-141-3p, hsa-miR-205-5p, hsa-miR-223-3p, hsa-miR-31-5p, hsa-miR-944, hsa-miR-200b-3p, hsa-miR-135b-5p, hsa-miR-31-3p, hsa-miR-223-5p and hsa-miR-200c-3p), and five were upregulated (hsa-miR-181a-5p, hsa-miR-181c-5p, hsa-miR-149-5p, hsa-miR-138-5p and hsa-miR-199a-3p) in COF compared to normal bone. Eighteen common target genes were predicted, and the leader genes approach identified the following genes involved in human COF: EZH2, XIAP, MET and TGFBR1. According to the biology of bone and COF, the most relevant KEGG pathways revealed by enrichment analysis were proteoglycans in cancer, miRNAs in cancer, pathways in cancer, p53-, PI3K-Akt-, FoxO- and TGF-beta signalling pathways, which were previously found to be differentially regulated in bone neoplasms, odontogenic tumours and osteogenesis. miRNA dysregulation occurs in COF, and EZH2, XIAP, MET and TGFBR1 are potential targets for functional analysis validation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Behavioral Interventions to Prevent or Delay Dementia: Protocol for a Randomized Comparative Effectiveness Study.

PubMed

Smith, Glenn; Chandler, Melanie; Locke, Dona Ec; Fields, Julie; Phatak, Vaishali; Crook, Julia; Hanna, Sherrie; Lunde, Angela; Morris, Miranda; Graff-Radford, Michelle; Hughes, Christine A; Lepore, Susan; Cuc, Andrea; Caselli, Maria; Hurst, Duane; Wethe, Jennifer; Francone, Andrea; Eilertsen, Jeanne; Lucas, Pauline; Hoffman Snyder, Charlene; Kuang, LeeAnn; Becker, Marigrace; Dean, Pamela; Diehl, Nancy; Lofquist, Marvin; Vanderhook, Shirley; Myles, Diana; Cochran, Denise

2017-11-27

Currently, people at risk for dementia and their caregivers are confronted with confusing choices about what behavioral interventions are most effective. The objective of this study is to determine which empirically supported behavioral interventions most impact the outcomes highly valued by patients with mild cognitive impairment and their partners. This protocol describes a comparative effectiveness trial targeting 300 participants with mild cognitive impairment and their study partners. The trial is being conducted at the Mayo Clinic campuses in Arizona, Florida, Minnesota, and the University of Washington in Seattle. The study examines the contribution of five behavioral interventions (yoga, memory compensation training, computerized cognitive training, support groups, and wellness education) on primary outcomes of participant and partner quality of life and self-efficacy. In this unique 10-day multicomponent intervention, groups of couples were randomized to have one of the five interventions withheld while receiving the other four. Although the longitudinal follow-up is still under way, enrollment results are available and reported. In total, 272 couples have been enrolled in the trial and follow-up visits continue. Outcomes will be assessed at the end-of-intervention and 6-, 12-, and 18-month follow-ups. We anticipate reporting on our primary and secondary outcomes across time points in the next 2 years. This paper describes the protocol for a randomized comparative effectiveness study of behavioral interventions to prevent or delay dementia. We describe of the rationale, design, power analysis, and analysis plan. Also because enrollment is complete and we are in follow-up phases of the study, we have included enrollment data from the trial.  ClinicalTrials.gov NCT02265757; http://clinicaltrials.gov/ctsshow/ NCT02265757 (Archived by WebCite at http://www.webcitation.org/6ueRfwSYv). ©Glenn Smith, Melanie Chandler, Dona EC Locke, Julie Fields, Vaishali Phatak, Julia Crook, Sherrie Hanna, Angela Lunde, Miranda Morris, Michelle Graff-Radford, Christine A Hughes, Susan Lepore, Andrea Cuc, Maria Caselli, Duane Hurst, Jennifer Wethe, Andrea Francone, Jeanne Eilertsen, Pauline Lucas, Charlene Hoffman Snyder, LeeAnn Kuang, Marigrace Becker, Pamela Dean, Nancy Diehl, Marvin Lofquist, Shirley Vanderhook, Diana Myles, Denise Cochran. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 27.11.2017.

Obituary: Preston F. Gott, 1919-2002

NASA Astrophysics Data System (ADS)

Myles, Charles Wesley

2003-12-01

Preston F. Gott, Professor Emeritus of Physics and former Director of the Observatories at Texas Tech University, died 13 January 2002 after a bout with Cancer. Mr. Gott was born 21 November 1919 in Waxahachie (Ellis County) Texas. He received his Bachelor of Science and Master of Arts degrees from the University of Texas at Austin. His first wife, Edna Maynard Gott, passed away in 1986; their two children are Eugene Willard Gott and Edith Suzanne Gott. After his retirement from Texas Tech University in 1989, he married Orene Whitcomb Peddicord, M.D. on 14 May 1991 and they lived in Odessa, Texas. Preston joined the Texas Tech University (TTU) faculty in 1948 and taught physics and astronomy there for 41 years, before retiring in 1989. He was responsible for starting astronomy teaching within the Physics department. He also developed, and taught for many years, a very popular, hands-on photography course in that department. It is due to Preston's persistence and determination that TTU has two astronomy observatories devoted to teaching. Because of his efforts, the on-campus observatory, Igor, was donated to TTU by White Sands Proving Grounds, New Mexico. He is also primarily responsible for obtaining the land, equipment and construction funds for an off campus observatory. In 1991, the TTU Board of Regents named the latter facility the Preston F. Gott Skyview Observatory. He also developed a private Mountainside Observatory in Fort Davis, Texas. Until recently, Preston was listed as a Senior Scientist at NASA's Jet Propulsion Laboratory in Pasadena, CA where he worked several summers on the moon and mars lander projects. In the 1950s and 1960s, he worked several summers at the White Sands Proving Grounds in New Mexico. In that period, he was also a consultant and frequent Visiting Scientist at the Aberdeen Proving Ground in Maryland. Preston was a very generous donor to the Department of Physics and the Texas Tech University. He endowed the Gott Gold Tooth Scholarship Award in Physics and also endowed a scholarship in the Women's Studies Program, in memory of his first wife, long time TTU Economics Professor Edna Gott. He was a true gentleman and a friend to all who knew him. He will be sorely missed. He is survived by his wife, Orene, and his children, Eugene and Suzanne. His stepchildren are Ruth, Benita, and Diana (who pre-deceased him).

Glycoprotein-Specific Antibodies Produced by DNA Vaccination Protect Guinea Pigs from Lethal Argentine and Venezuelan Hemorrhagic Fever.

PubMed

Golden, Joseph W; Maes, Piet; Kwilas, Steven A; Ballantyne, John; Hooper, Jay W

2016-01-20

Several members of the Arenaviridae can cause acute febrile diseases in humans, often resulting in lethality. The use of convalescent-phase human plasma is an effective treatment in humans infected with arenaviruses, particularly species found in South America. Despite this, little work has focused on developing potent and defined immunotherapeutics against arenaviruses. In the present study, we produced arenavirus neutralizing antibodies by DNA vaccination of rabbits with plasmids encoding the full-length glycoprotein precursors of Junín virus (JUNV), Machupo virus (MACV), and Guanarito virus (GTOV). Geometric mean neutralizing antibody titers, as measured by the 50% plaque reduction neutralization test (PRNT(50)), exceeded 5,000 against homologous viruses. Antisera against each targeted virus exhibited limited cross-species binding and, to a lesser extent, cross-neutralization. Anti-JUNV glycoprotein rabbit antiserum protected Hartley guinea pigs from lethal intraperitoneal infection with JUNV strain Romero when the antiserum was administered 2 days after challenge and provided some protection (∼30%) when administered 4 days after challenge. Treatment starting on day 6 did not protect animals. We further formulated an IgG antibody cocktail by combining anti-JUNV, -MACV, and -GTOV antibodies produced in DNA-vaccinated rabbits. This cocktail protected 100% of guinea pigs against JUNV and GTOV lethal disease. We then expanded on this cocktail approach by simultaneously vaccinating rabbits with a combination of plasmids encoding glycoproteins from JUNV, MACV, GTOV, and Sabia virus (SABV). Sera collected from rabbits vaccinated with the combination vaccine neutralized all four targets. These findings support the concept of using a DNA vaccine approach to generate a potent pan-arenavirus immunotherapeutic. Arenaviruses are an important family of emerging viruses. In infected humans, convalescent-phase plasma containing neutralizing antibodies can mitigate the severity of disease caused by arenaviruses, particularly species found in South America. Because of variations in potency of the human-derived product, limited availability, and safety concerns, this treatment option has essentially been abandoned. Accordingly, despite this approach being an effective postinfection treatment option, research on novel approaches to produce potent polyclonal antibody-based therapies have been deficient. Here we show that DNA-based vaccine technology can be used to make potently neutralizing antibodies in rabbits that exclusively target the glycoproteins of several human-pathogenic arenaviruses found in South America, including JUNV, MACV, GTOV, and SABV. These antibodies protected guinea pigs from lethal disease when given post-virus challenge. We also generated a purified antibody cocktail with antibodies targeting three arenaviruses and demonstrated protective efficacy against all three targets. Our findings demonstrate that use of the DNA vaccine technology could be used to produce candidate antiarenavirus neutralizing antibody-based products. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Glycoprotein-Specific Antibodies Produced by DNA Vaccination Protect Guinea Pigs from Lethal Argentine and Venezuelan Hemorrhagic Fever

PubMed Central

Golden, Joseph W.; Maes, Piet; Kwilas, Steven A.; Ballantyne, John

2016-01-01

ABSTRACT Several members of the Arenaviridae can cause acute febrile diseases in humans, often resulting in lethality. The use of convalescent-phase human plasma is an effective treatment in humans infected with arenaviruses, particularly species found in South America. Despite this, little work has focused on developing potent and defined immunotherapeutics against arenaviruses. In the present study, we produced arenavirus neutralizing antibodies by DNA vaccination of rabbits with plasmids encoding the full-length glycoprotein precursors of Junín virus (JUNV), Machupo virus (MACV), and Guanarito virus (GTOV). Geometric mean neutralizing antibody titers, as measured by the 50% plaque reduction neutralization test (PRNT50), exceeded 5,000 against homologous viruses. Antisera against each targeted virus exhibited limited cross-species binding and, to a lesser extent, cross-neutralization. Anti-JUNV glycoprotein rabbit antiserum protected Hartley guinea pigs from lethal intraperitoneal infection with JUNV strain Romero when the antiserum was administered 2 days after challenge and provided some protection (∼30%) when administered 4 days after challenge. Treatment starting on day 6 did not protect animals. We further formulated an IgG antibody cocktail by combining anti-JUNV, -MACV, and -GTOV antibodies produced in DNA-vaccinated rabbits. This cocktail protected 100% of guinea pigs against JUNV and GTOV lethal disease. We then expanded on this cocktail approach by simultaneously vaccinating rabbits with a combination of plasmids encoding glycoproteins from JUNV, MACV, GTOV, and Sabia virus (SABV). Sera collected from rabbits vaccinated with the combination vaccine neutralized all four targets. These findings support the concept of using a DNA vaccine approach to generate a potent pan-arenavirus immunotherapeutic. IMPORTANCE Arenaviruses are an important family of emerging viruses. In infected humans, convalescent-phase plasma containing neutralizing antibodies can mitigate the severity of disease caused by arenaviruses, particularly species found in South America. Because of variations in potency of the human-derived product, limited availability, and safety concerns, this treatment option has essentially been abandoned. Accordingly, despite this approach being an effective postinfection treatment option, research on novel approaches to produce potent polyclonal antibody-based therapies have been deficient. Here we show that DNA-based vaccine technology can be used to make potently neutralizing antibodies in rabbits that exclusively target the glycoproteins of several human-pathogenic arenaviruses found in South America, including JUNV, MACV, GTOV, and SABV. These antibodies protected guinea pigs from lethal disease when given post-virus challenge. We also generated a purified antibody cocktail with antibodies targeting three arenaviruses and demonstrated protective efficacy against all three targets. Our findings demonstrate that use of the DNA vaccine technology could be used to produce candidate antiarenavirus neutralizing antibody-based products. PMID:26792737

Examination of Single- and Multi-Channel GPR Bridge Deck Condition Assessment Methods with Comparison to Complementary NDE Results

NASA Astrophysics Data System (ADS)

Romero, Francisco A.; Manacorda, Guido; Simi, Alessandro; Gucunski, Nenad; Parvardeh, Hooman

2013-04-01

A sixteen-channel GPR system which houses both longitudinally- and transversely-polarized, 2.0 GHz antenna elements within a single housing was compared with a single-channel GPR system that was separately using both 1.5GHz and 2.6GHz antennas oriented in the transverse polarization, for the purpose of determining effectiveness of bridge deck condition assessment. The multi-channel system has obvious benefits which include closely-spaced GPR antennas (channels) that provide better lateral resolution, as well as combined data sets from co-linear antennas oriented in both the transverse and longitudinal polarizations, which has benefits for imaging within the deck's internal structure. However, the primary objective was to determine whether the multi-channel system would perform in a similar manner to proven single-channel GPR technology during an attenuation-based GPR condition assessment on an older, partially deteriorated deck in northwestern New Jersey that is annually exposed to freeze-thaw conditions as well as de-icing salts. These assessments were made by focusing on identifying the strongest reflections from the upper mat of transversely-oriented rebars within the deck and comparing reflection strength, or conversely, attenuation of the GPR signal, from each of the 'picked' GPR rebar responses. Coordinates for each of the GPR picks, along with amplitude or attenuation measurements, were gridded and contour-plotted for the purpose of identifying areas identified as either relatively deteriorated or sound. Initially, results were compared for data with no applied correction that takes into account GPR signal attenuation with increasing depth within the concrete deck. Final GPR maps were produced incorporating a depth-correction technique similar to what is described by Barnes, et. al., Romero, et. al, and Gucunski, et. al., a process which has been clearly demonstrated to better correlate GPR results with not only ground truth (cores, sounding) but also with other NDE technologies. Not only did all the single- and multi-channel system comparisons generate nearly identical deterioration maps when GPR results were compared and examined, but mapped results obtained from other NDE methods on the same deck were used to identify zones where corrosive environment (electrical resistivity - ER) elastic modulus (ultrasonic surface wave - USW), and identified delaminations (impact-echo - IE) had commonality with the GPR results. A summary of the equipment used, as well as general data collection and analysis procedures is provided for the GPR condition assessments. Brief descriptions of background and references to how the complementary NDT technologies are deployed, and how data are interpreted, are also discussed. Comparative maps for all technologies are used for illustrative purposes.

Psychometric Properties of the Orgasm Rating Scale in Context of Sexual Relationship in a Spanish Sample.

PubMed

Arcos-Romero, Ana Isabel; Moyano, Nieves; Sierra, Juan Carlos

2018-05-01

The Orgasm Rating Scale (ORS) is one of the few self-reported measures that evaluates the multidimensional subjective experience of orgasm. The objective of this study was to examine the psychometric properties of the ORS in context of sex-with-partner in a Spanish sample. We examined a sample of 842 adults from the general Spanish population (310 men, 532 women; mean age = 27.12 years, SD = 9.8). The sample was randomly divided into two, with a balanced proportion of men and women between each sub-sample. Sub-sample 1 consisted of 100 men and 200 women (33.3% and 66.6%) with a mean age of 27.77 years (SD = 10.05). Sub-sample 2 consisted of 210 men and 332 women (38.7% and 61.3%) with a mean age of 26.77 years (SD = 9.65). The ORS, together with the Sexual Opinion Survey-6 and the Massachusetts General Hospital-Sexual Functioning Questionnaire, was administered online. The survey included a consent form, in which confidentiality and anonymity were guaranteed. Based on exploratory factor analysis, we obtained a reduced 25-item version of the ORS, distributed along 4 dimensions (affective, sensory, intimacy, and rewards). We performed both exploratory factor analysis and confirmatory factor analysis. The Spanish version of the ORS had adequate values of reliability that ranged from .78-.93. The 4 factors explained 59.78% of the variance. The factor structure was invariant across gender at a configural level. Scores from the ORS positively correlated with erotophilia and sexual satisfaction. The scale was useful to differentiate between individuals with orgasmic difficulties and individuals with no difficulties. We found that individuals with orgasmic difficulties showed a lower intensity in the affective, intimacy, and sensorial manifestations of orgasm. This version of the ORS could provide an optimum measure for the clinical assessment to identify individuals with difficulties in their orgasmic capacity, thus, it could be used as screening device for orgasmic dysfunction. The ORS is an appropriate measure for its use for both research and clinical purposes. As limitations, quota sampling implies that the extent to which the results can be generalized is modest. Measurement invariance did not reach the level of weak invariance, and it was not tested across sexual orientation because most individuals identified themselves as heterosexual. The ORS is a multidimensional measure of the subjective experience of orgasm which has adequate psychometric properties; it is a reliable and valid scale. Arcos-Romero AI, Moyano N, Sierra JC. Psychometric Properties of the Orgasm Rating Scale in Context of Sexual Relationship in a Spanish Sample. J Sex Med 2018;15:741-749. Copyright © 2018 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

Image-based modeling of flow and reactive transport in porous media

NASA Astrophysics Data System (ADS)

Qin, Chao-Zhong; Hoang, Tuong; Verhoosel, Clemens V.; Harald van Brummelen, E.; Wijshoff, Herman M. A.

2017-04-01

Due to the availability of powerful computational resources and high-resolution acquisition of material structures, image-based modeling has become an important tool in studying pore-scale flow and transport processes in porous media [Scheibe et al., 2015]. It is also playing an important role in the upscaling study for developing macroscale porous media models. Usually, the pore structure of a porous medium is directly discretized by the voxels obtained from visualization techniques (e.g. micro CT scanning), which can avoid the complex generation of computational mesh. However, this discretization may considerably overestimate the interfacial areas between solid walls and pore spaces. As a result, it could impact the numerical predictions of reactive transport and immiscible two-phase flow. In this work, two types of image-based models are used to study single-phase flow and reactive transport in a porous medium of sintered glass beads. One model is from a well-established voxel-based simulation tool. The other is based on the mixed isogeometric finite cell method [Hoang et al., 2016], which has been implemented in the open source Nutils (http://www.nutils.org). The finite cell method can be used in combination with isogeometric analysis to enable the higher-order discretization of problems on complex volumetric domains. A particularly interesting application of this immersed simulation technique is image-based analysis, where the geometry is smoothly approximated by segmentation of a B-spline level set approximation of scan data [Verhoosel et al., 2015]. Through a number of case studies by the two models, we will show the advantages and disadvantages of each model in modeling single-phase flow and reactive transport in porous media. Particularly, we will highlight the importance of preserving high-resolution interfaces between solid walls and pore spaces in image-based modeling of porous media. References Hoang, T., C. V. Verhoosel, F. Auricchio, E. H. van Brummelen, and A. Reali (2016), Mixed Isogeometric Finite Cell Methods for the Stokes problem, Computer Methods in Applied Mechanics and Engineering, doi:10.1016/j.cma.2016.07.027. Scheibe, T. D., W. A. Perkins, M. C. Richmond, M. I. McKinley, P. D. J. Romero-Gomez, M. Oostrom, T. W. Wietsma, J. A. Serkowski, and J. M. Zachara (2015), Pore-scale and multiscale numerical simulation of flow and transport in a laboratory-scale column, Water Resources Research, 51(2), 1023-1035, doi:10.1002/2014WR015959. Verhoosel, C. V., G. J. van Zwieten, B. van Rietbergen, and R. de Borst (2015), Image-based goal-oriented adaptive isogeometric analysis with application to the micro-mechanical modeling of trabecular bone, Computer Methods in Applied Mechanics and Engineering, 284(February), 138-164, doi:10.1016/j.cma.2014.07.009.

Heavy metals, arsenic, and pesticide contamination in an area with high incidence of chronic kidney disease of non-traditional causes in El Salvador

NASA Astrophysics Data System (ADS)

Lopez, D. A.; Ribó, A.; Quinteros, E.; Mejia, R.; Jovel, R.; VanDervort, D.; Orantes, C. M.

2013-12-01

Chronic kidney disease of non-traditional causes is epidemic in Central America, Southern Mexico and other regions of the world such as Sri Lanka, where the origin of the illness is attributed to exposure to agrochemicals and arsenic in soils and groundwater. In Central America, several causes have been suggested for this illness including: high ambient temperatures and chronic dehydration, and toxic effects of agrochemicals. Previous research using step-wise multivariate regression in El Salvador found statistically significant correlation between the spatial distribution of the number of sick people per thousand inhabitants and the percent area cultivated with sugar cane, cotton, and beans, and maximum ambient temperature, with sugar cane cultivation as the most significant factor. This study aims to investigate the possible effects of agricultural activities in the occurrence of this illness looking at heavy metal, arsenic and pesticide contamination in soil, water and sediments of a community located in Bajo Lempa region (Ciudad Romero, El Salvador) and heavily affected by this illness. The Bajo Lempa region is close to Lempa River delta, in the Pacific coast. Ground and surface water, sediment and soil samples were collected in the village where the patients live and in the agricultural areas where they work. With respect to the heavy metals, lead and cadmium where detected in the soils but below the standards for cultivated soils, however, they were not detected in the majority of surface and groundwater. Of the inorganic contaminants, arsenic was present in most soil, sediments, and water samples with some concentrations considerable higher than the standards for cultivated lands and drinking water. Statistically different concentrations in soils were found for the village soils and the cultivated soils, with arsenic higher in the cultivated soils. For the pesticides, results show a significant pollution of soil and groundwater of organochlorine pesticides such as DDT and its metabolites (DDE and DDD), which are banned in El Salvador, Endosulfan Alpha isomer and Beta isomer, Endosulfan sulfate and 2.4 D. Lindane and Heptachlor Hexachlorobenzene also were found. Glyphosate and 2,4-D were found in the soils. These herbicides together with Paraquat are the most used herbicides in El Salvador. Paraquat contamination was found in drinking water from the local distribution network and in groundwater from domestic wells. These results show that the people of Bajo Lempa have been exposed to a variety of contaminants that have known toxic effects on the kidney. Investigation of these contaminants in the affected population is the next step to know the origin of this illness in El Salvador.

Temporal dynamics of plant succession in abandoned field in Mediterranean mountain areas: farming terraces and sloping fields (Iberian System, Spain)

NASA Astrophysics Data System (ADS)

Nadal-Romero, Estela; Errea, Paz; Lasanta, Teodoro

2017-04-01

Cropland abandonment is an important problem in mountain areas worldwide. This process represents the change from an agricultural management to an abandoned land in which a complex plant succession process occurs, with important hydromorphological effects, and consequences in water resources availability and soil erosion. Literature indicates that plant succession depends on multiple natural factors (soil properties, topography, climate, lithology, and distance to natural covers…) and anthropogenic factors (age of abandonment, management of each field during the cultivation period and after the abandonment…). Despite the advances, much is unknown about the vegetation succession, due to the complexity of ecological and social conditions in which land abandonment occurs. Recently, it is shown that only local factors can explain the heterogeneity of the process (Burel and Baudry, 2002; Jouba and Alados, 2012). In this work, we analyze the diversity of vegetation cover in abandonment fields in Cameros Viejo (Iberian System, Spain), related to the different field patterns (terraces and sloping fields) and the age of abandonment. Agricultural lands were delimited using aerial photographs from 1956 and 1978. The current land cover was obtained from SIOSE (Information System of Land Occupation in Spain). According to our cartography, cultivated land occupied as much as 15,491 ha (39% of the area), remaining abandoned 14,505 ha by 1978. Farming terraces occupied 55.9% of the abandoned area, and 44.1% as sloping fields. On the other hand, our cartography highlights the complexity of current land cover of abandoned fields in a landscape matrix of scrubland. Our results suggest that ecological succession is faster in farming terraces than in sloping fields, mostly until scrubland phase is attained. They also suggest that current land cover is better explained by the physical conditions of each field than by the abandonment age. Acknowledgement This research was supported by the DESEMON and ESPAS projects (CGL2014-52135-C3-3-R and CGL2015-65569-R, funded by the MINECO-FEDER). The "Geomorphology and Global Change" and the "Climate, water, global change and natural systems" research groups were financed by the Aragón Government and the European Social Fund (ESF-FSE). Estela Nadal-Romero was the recipient of a "Ramón y Cajal" postdoctoral contract (Spanish Ministry of Economy and Competitiveness). References Burel, F. & Baudry, J. (2002): Ecología del paisaje. Conceptos, métodos y aplicaciones. Ediciones Mundi-Prensa: 353 pp., Madrid. Kouba, Y. & Alados, C.L. (2012): Spatio-temporal dynamics of Quercus faginea forest in the Spanish Central Pre-Pyrenees. European Journal of Forest Research, 131: 369-379.

Badlands and the Carbon cycle: a significant source of petrogenic organic carbon in rivers and marine environments?

NASA Astrophysics Data System (ADS)

Copard, Yoann; Eyrolle-Boyer, Frederique; Radakovitch, Olivier; Poirel, Alain; Raimbault, Patrick; Lebouteiller, Caroline; Gairoard, Stéphanie; Di-Giovanni, Christian

2016-04-01

A key issue in the study of carbon biogeochemical cycle is to well constrain each carbon origin in term of fluxes between all C-reservoirs. From continental surfaces to oceans, rivers convey particulate organic carbon originate from the biomass (biospheric OC) and /or from the sedimentary rocks (petrogenic OC). Existence and importance of this petrogenic OC export to oceans was debated for several decades (see Copard et al., 2007 and ref.), but it is now assumed that 20% of the global carbon export to ocean has a geological origin (Galy et al., 2015). The main current challenge is to constrain the major contributors to this petrogenic OC flux. Amongst the expected sedimentary sources of petrogenic OC in rivers, sedimentary rocks forming badlands can be rightly considered as some viable candidates. Indeed these rocks show a strong erosion rate, may exceed 50 kt km-2 y-1 and in addition, shales, marls and argillaceous rocks, frequently forming badlands (see Nadal-Romero et al., 2011 for the Mediterranean area), contain a significant amount of petrogenic OC (frequently over 0.50 wt. %, Ronov and Yaroshevsky 1976). Our work illustrates the contribution of badlands, mainly distributed within the Durance catchment (a main tributary of the Rhône river), in the petrogenic OC export to the Mediterranean Sea. The approach is based on (i) the use of previous and new data on radiogenic carbon, (ii) bulk organic geochemistry (Rock-Eval pyrolysis), (iii) optical quantification of particulate OM (palynofacies), performed on suspended sediments from the Durance, the Rhône rivers and from small rivers draining the badlands. A mean erosion rate of badlands, previously calculated for instrumented catchments (SOERE Draix-Bléone, Graz et al., 2012) was also applied to the badlands disseminated within the Durance catchment. These different methodologies converge to a petrogenic contribution of the OC export to the Mediterranean Sea close to 30 %. Badlands from the Durance catchment, which represent less than 0.25 % of the Rhône surface, may yield 15 % of the POC annually delivered to the sea. In other words, 50% of the petrogenic OC would have a badlands origin. At a global scale, we assume that badlands could significantly contribute to the delivery of petrogenic OC to the marine environments. references: Copard Y, Amiotte-Suchet P, Di-Giovanni C, 2007. Earth Planet. Sci. Let., 258, 345-357. Galy V, Peuker-Ehrenbrinck B, Eglinton T, 2015. Nature, 501, 204-208. Graz Y, Di Giovanni C, Copard Y, Mathys N, et al. 2012. Earth Surf. Proc. Land., 37, 1263-1271. Ronov AB, Yaroshevsky AA, 1976. Geochem. Intern. 13, 1761-1795.

List based prefetch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyle, Peter; Christ, Norman; Gara, Alan

A list prefetch engine improves a performance of a parallel computing system. The list prefetch engine receives a current cache miss address. The list prefetch engine evaluates whether the current cache miss address is valid. If the current cache miss address is valid, the list prefetch engine compares the current cache miss address and a list address. A list address represents an address in a list. A list describes an arbitrary sequence of prior cache miss addresses. The prefetch engine prefetches data according to the list, if there is a match between the current cache miss address and the listmore » address.« less

List based prefetch

DOEpatents

Boyle, Peter [Edinburgh, GB; Christ, Norman [Irvington, NY; Gara, Alan [Yorktown Heights, NY; Kim,; Changhoan, [San Jose, CA; Mawhinney, Robert [New York, NY; Ohmacht, Martin [Yorktown Heights, NY; Sugavanam, Krishnan [Yorktown Heights, NY

2012-08-28

A list prefetch engine improves a performance of a parallel computing system. The list prefetch engine receives a current cache miss address. The list prefetch engine evaluates whether the current cache miss address is valid. If the current cache miss address is valid, the list prefetch engine compares the current cache miss address and a list address. A list address represents an address in a list. A list describes an arbitrary sequence of prior cache miss addresses. The prefetch engine prefetches data according to the list, if there is a match between the current cache miss address and the list address.

Hierarchical auto-configuration addressing in mobile ad hoc networks (HAAM)

NASA Astrophysics Data System (ADS)

Ram Srikumar, P.; Sumathy, S.

2017-11-01

Addressing plays a vital role in networking to identify devices uniquely. A device must be assigned with a unique address in order to participate in the data communication in any network. Different protocols defining different types of addressing are proposed in literature. Address auto-configuration is a key requirement for self organizing networks. Existing auto-configuration based addressing protocols require broadcasting probes to all the nodes in the network before assigning a proper address to a new node. This needs further broadcasts to reflect the status of the acquired address in the network. Such methods incur high communication overheads due to repetitive flooding. To address this overhead, a new partially stateful address allocation scheme, namely Hierarchical Auto-configuration Addressing (HAAM) scheme is extended and proposed. Hierarchical addressing basically reduces latency and overhead caused during address configuration. Partially stateful addressing algorithm assigns addresses without the need for flooding and global state awareness, which in turn reduces the communication overhead and space complexity respectively. Nodes are assigned addresses hierarchically to maintain the graph of the network as a spanning tree which helps in effectively avoiding the broadcast storm problem. Proposed algorithm for HAAM handles network splits and merges efficiently in large scale mobile ad hoc networks incurring low communication overheads.

19 CFR 10.422 - Submission of certificate of eligibility.

Code of Federal Regulations, 2010 CFR

2010-04-01

... following information: (i) The legal name, address, telephone and e-mail address of the importer of record... and e-mail address, if available; (iii) The legal name, address, telephone and e-mail address of the exporter of the good (if different from the producer); (iv) The legal name, address, telephone and e-mail...

75 FR 41790 - Address Management Services-Elimination of the Manual Card Option for Address Sequencing Services

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-19

... Electronic Address Sequencing (EAS) service processes a customer's addresses file for walk sequence and/or... POSTAL SERVICE 39 CFR Part 111 Address Management Services--Elimination of the Manual Card Option for Address Sequencing Services AGENCY: Postal Service TM . ACTION: Proposed rule. SUMMARY: The Postal...

19 CFR 10.411 - Certification of origin or other information.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., address, telephone and e-mail address of the importer of record of the good (if known); (ii) The legal name, address, telephone and e-mail address of the exporter of the good (if different from the producer); (iii) The legal name, address, telephone and e-mail address of the producer of the good (if known); (iv...

Research of future network with multi-layer IP address

NASA Astrophysics Data System (ADS)

Li, Guoling; Long, Zhaohua; Wei, Ziqiang

2018-04-01

The shortage of IP addresses and the scalability of routing systems [1] are challenges for the Internet. The idea of dividing existing IP addresses between identities and locations is one of the important research directions. This paper proposed a new decimal network architecture based on IPv9 [11], and decimal network IP address from E.164 principle of traditional telecommunication network, the IP address level, which helps to achieve separation and identification and location of IP address, IP address form a multilayer network structure, routing scalability problem in remission at the same time, to solve the problem of IPv4 address depletion. On the basis of IPv9, a new decimal network architecture is proposed, and the IP address of the decimal network draws on the E.164 principle of the traditional telecommunication network, and the IP addresses are hierarchically divided, which helps to realize the identification and location separation of IP addresses, the formation of multi-layer IP address network structure, while easing the scalability of the routing system to find a way out of IPv4 address exhausted. In addition to modifying DNS [10] simply and adding the function of digital domain, a DDNS [12] is formed. At the same time, a gateway device is added, that is, IPV9 gateway. The original backbone network and user network are unchanged.

Nutritive quality of romanian hemp varieties (Cannabis sativa L.) with special focus on oil and metal contents of seeds

PubMed Central

2012-01-01

Background The study aims to determine the nutritional value of hemp seed expressed by the oil content and by the concentration of metals (Ca, Mg, K, Fe, Mn, Zn and Cd), for five varieties of monoecious and dioecious hemp seeds approved in Romania, comparative with the concentration of these metals in the soil. Results The content of oil in hempseed registers a slight decrease in the production records of 2011, losses due to drought and low levels of precipitation during the growth period. The greatest loss is found in Diana monoecious variety (26.54-20.82%) followed by Zenit varieties (27.37-22.97%), Armanca (29.27-25.32%), Silvana (28.89-25.04%) and Denise (26.96-25.30%). Siccative hemp oil has a yellowish green color and an iodine index of 140–156 g I2/100 g oil. Hemp seed are rich in mineral based Ca (144–955 mg/100 g seed), Mg (237–694 mg/100 g seed), K (463–2821 mg/100 g seed), Fe (1133-2400 mg.kg-1), Mn (63–110 mg.kg-1) and Zn (42-94 mg.kg-1). For the soil the following macroelements concentrations were determined: Ca (2100–2520 mg.kg-1), Mg (320–376 mg.kg-1) and K (232–257 mg.kg-1). Mn (156–197 mg.kg-1) and Zn (54–67 mg.kg-1) remain within normal limits for Romania. The soils in the experience area contain large amounts of Fe (19000–20430 mg.kg-1). The presence of K in large quantities determines the accumulation of large quantities of Fe in the soil. Conclusion Hempseed belonging to the five Romanian varieties are rich source of nutrients (Ca, Mg, K) and unsaturated oil easily digestible by the body, but the presence of Cd concentrations above the upper limit puts a question mark over the use of seeds in various food products. Hemp extracts easily certain metals from the soil. Significant amounts of Fe (1133–2400 mg.kg-1), Mn (63–110 mg.kg-1), Zn (42–94 mg.kg-1) and Cd (1.3-4.0 mg.kg-1) are found in hemp seeds. Hemp (Cannabis sativa L.) is included among plants suitable for phytoremediation of soil contaminated with cadmium, zinc and iron. PMID:23088580

The Effectiveness of eHealth Technologies on Weight Management in Pregnant and Postpartum Women: Systematic Review and Meta-Analysis.

PubMed

Sherifali, Diana; Nerenberg, Kara A; Wilson, Shanna; Semeniuk, Kevin; Ali, Muhammad Usman; Redman, Leanne M; Adamo, Kristi B

2017-10-13

The emergence and utilization of electronic health (eHealth) technologies has increased in a variety of health interventions. Exploiting the real-time advantages offered by mobile technologies during and after pregnancy has the potential to empower women and encourage behaviors that may improve maternal and child health. The objective of this study was to assess the effectiveness of eHealth technologies for weight management during pregnancy and the postpartum period and to review the efficacy of eHealth technologies on health behaviors, specifically nutrition and physical activity. A systematic search was conducted of the following databases: MEDLINE, EMBASE, Cochrane database of systematic reviews (CDSR), Cochrane central register of controlled trials (CENTRAL), CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO. The search included studies published from 1990 to July 5, 2016. All relevant primary studies that involved randomized controlled trials (RCTs), non-RCTs, before-and-after studies, historically controlled studies, and pilot studies were included. The study population was adult women of childbearing age either during pregnancy or the postpartum period. eHealth weight management intervention studies targeting physical activity, nutrition, or both, over a minimum 3-month period were included. Titles and abstracts, as well as full-text screening were conducted. Study quality was assessed using Cochrane's risk of bias tool. Data extraction was completed by a single reviewer, which was then verified by a second independent reviewer. Results were meta-analyzed to calculate pooled estimates of the effect, wherever possible. Overall, 1787 and 176 citations were reviewed at the abstract and full-text screening stages, respectively. A total of 10 studies met the inclusion criteria ranging from high to low risk of bias. Pooled estimates from studies of the effect for postpartum women resulted in a significant reduction in weight (-2.55 kg, 95% CI -3.81 to -1.28) after 3 to 12 months and six studies found a nonsignificant reduction in weight gain for pregnant women (-1.62 kg, 95% CI -3.57 to 0.33) at approximately 40 weeks. This review found evidence for benefits of eHealth technologies on weight management in postpartum women only. Further research is still needed regarding the use of these technologies during and after pregnancy. ©Diana Sherifali, Kara A Nerenberg, Shanna Wilson, Kevin Semeniuk, Muhammad Usman Ali, Leanne M Redman, Kristi B Adamo. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.10.2017.

Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, James E.; Wiel, Stephen

2001-02-16

Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and the United Nations Foundation (UNF) recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labelingmore » programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This guidebook was prepared over the course of the past year with significant contribution from the authors and reviewers mentioned previously. Their diligent participation has made this the international guidance tool it was intended to be. The lead authors would also like to thank the following individuals for their support in the development, production, and distribution of the guidebook: Marcy Beck, Elisa Derby, Diana Dhunke, Ted Gartner, and Julie Osborn of Lawrence Berkeley National Laboratory as well as Anthony Ma of Bevilacqua-Knight, Inc. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards-setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the programs and on the design of the labels and standards themselves. In addition, it directs the reader to references and other resources likely to be useful in conducting the activities described and includes a chapter on energy policies and programs that complement appliance efficiency labels and standards. This guidebook attempts to reflect the essential framework of labeling and standards programs. It is the intent of the authors and sponsors to distribute copies of this book worldwide at no charge for the general public benefit. The guidebook is also available on the web at www.CLASPonline.org and can be downloaded to be used intact or piecemeal for whatever beneficial purposes readers may conceive.« less

21 CFR 56.106 - Registration.

Code of Federal Regulations, 2010 CFR

2010-04-01

... institution operating the IRB and the name, mailing address, phone number, facsimile number, and electronic... address), phone number, facsimile number, and electronic mail address; each IRB chairperson's name, phone number, and electronic mail address; and the name, mailing address, phone number, facsimile number, and...

21 CFR 56.106 - Registration.

Code of Federal Regulations, 2013 CFR

2013-04-01

... institution operating the IRB and the name, mailing address, phone number, facsimile number, and electronic... address), phone number, facsimile number, and electronic mail address; each IRB chairperson's name, phone number, and electronic mail address; and the name, mailing address, phone number, facsimile number, and...

21 CFR 56.106 - Registration.

Code of Federal Regulations, 2014 CFR

2014-04-01

... institution operating the IRB and the name, mailing address, phone number, facsimile number, and electronic... address), phone number, facsimile number, and electronic mail address; each IRB chairperson's name, phone number, and electronic mail address; and the name, mailing address, phone number, facsimile number, and...

Name-Based Address Mapping for Virtual Private Networks

NASA Astrophysics Data System (ADS)

Surányi, Péter; Shinjo, Yasushi; Kato, Kazuhiko

IPv4 private addresses are commonly used in local area networks (LANs). With the increasing popularity of virtual private networks (VPNs), it has become common that a user connects to multiple LANs at the same time. However, private address ranges for LANs frequently overlap. In such cases, existing systems do not allow the user to access the resources on all LANs at the same time. In this paper, we propose name-based address mapping for VPNs, a novel method that allows connecting to hosts through multiple VPNs at the same time, even when the address ranges of the VPNs overlap. In name-based address mapping, rather than using the IP addresses used on the LANs (the real addresses), we assign a unique virtual address to each remote host based on its domain name. The local host uses the virtual addresses to communicate with remote hosts. We have implemented name-based address mapping for layer 3 OpenVPN connections on Linux and measured its performance. The communication overhead of our system is less than 1.5% for throughput and less than 0.2ms for each name resolution.

The use of Mediterranean shrub to flight against the land degradation. The rainfall partitioning fluxes

NASA Astrophysics Data System (ADS)

García-Estringana, Pablo; Nieves Alonso-Blazquez, M.; Alegre, Jesús; Cerdà, Artemi

2014-05-01

Desertification can be triggered by the lost of vegetation (Izzo et al., 2013). One of the impacts of the lack of vegetation is the increase in the effective rainfall and then higher soil and water losses. Vegetation can reduce the effective rainfall by interception. To recover the land that is affected by Desertification we must select plant species that will intercept the rainfall, but will not avoid the rainfall to reach the soil. This is why, studies on the plant rainfall interception are relevant to flight Land Degradation processes. Soil erosion is highly dependent on the effective rainfall (Cerdà and Lasanta, 2005; Haile and Fetene; 2012; Miao et al., 2012, Prokop and Poręba, 2012). The amount of rainfall that reaches the soil surface and can contribute to detach and transport material is determined by the interception of plants. Interception is also a key factor of the watershed hydrology (Zema et al., 2012). The importance of the rainfall partitioning fluxes is related to the climatic conditions, as climate control the plant cover and the soil properties, and then the soil losses (Cerdà, 1998). Although the shrubs has been seen as a key vegetation cover in semiarid lands to control the soil and water losses (Cerdà and Doerr, 2007) little information is available about rainfall interception in Mediterranean shrub vegetation, due to technical difficulties to measure them in such small-sized vegetation (Belmonte Serrato and Romero Diaz, 1998). The aim of this work was to assess the influence of different Mediterranean shrubs (Retama sphaerocarpa, Colutea arborescens, Dorycnium pentaphyllum, Medicago strasseri, Pistacia Lentiscus and Quercus coccifera) on rainfall partitioning fluxes (interception losses, throughfall and stemflow) in semiarid environments. The experiment was carried out under natural rainfall conditions with live specimens during two years, with automatic measurement of rainfall partitioning fluxes. In order to assess the influence of biotic and abiotic factors on rainfall partitioning fluxes and their seasonal variation, twenty rainfall events, ten small-size events (P≤10 mm) and ten major events (P>10 mm), were selected. Great differences were observed among species, with interception losses varying between 10% for R. sphaerocarpa to greater than 36% for D. pentaphyllum and M. strasseri, and with stemflow percentages changing between less than 11% for D. pentaphyllum and M. strasseri and 20% for R. sphaerocarpa (Garcia-Estringana, 2011). Pistacia Lentiscus intercepted 21 % of the rainfall and Quercus coccifera 31 %. Species was the most important biotic factor, rainfall volume was the most significant abiotic factor. Stemflow percentages increased and interception losses percentages decreased as rainfall volume increased, both until a stable value reached when rainfall volume was greater than 10 mm. Stemflow and interception losses varied greatly in small events, consequently it is difficult to predict rainfall interception fluxes in semiarid regions, where small events are the most frequent ones. Rainfall volume events greater than 10 mm are much less frequent, but more rainfall is concentrated around the stem base, being during these events when species which used stemflow as an adaptive mechanism to aridity store water in deep soil layers. Stemflow reached their maximum values in autumn and winter, and their minimum values in summer, unlike interception losses, which were higher in summer, except for M. strasseri because it sheds all its leaves. Hydrologic impact of shrubs was very variable depending on the species, and its capacity to form dense communities. Therefore it makes this type of vegetation of great interest in the Mediterranean region, not only by the effect on soil protection (Garcia-Estringana et al., 2010), but also by the effect on hydrology and water availability in a region where water is a scarce resource and shrub vegetation is proliferating as a result of agricultural abandonment. Acknowledgements TThe research projects 07 M/0077/1998, 07 M/0023/2000 and RTA01-078-C2- 2, GL2008-02879/BTE, LEDDRA243857 and RECARE FP7 project 603498 supported this research. References: Belmonte Serrato, F., Romero Díaz, A. 1998. A simple technique for measuring rainfall interception by small shrub: "interception flow collection box. Hydrological Processes 12, 471-481. Cerdà, A. 1998. Relationship between climate and soil hydrological and erosional characteristics along climatic gradients in Mediterranean limestone areas. Geomorphology, 25, 123-134. Cerdà, A., Doerr, S.H. 2007. Soil wettability, runoff and erodibility of major dry-Mediterranean land use types on calcareous soils. Hydrological Processes, 21, 2325-2336. doi: 10.1016/j.catena.2008.03.010. Cerdà, A., Lasanta, A. 2005. Long-term erosional responses after fire in the Central Spanish Pyrenees: 1. Water and sediment yield. Catena, 60, 59-80. Garcia-Estringana, P. 2011. Efectos de diferentes tipos de vegetación mediterránea sobre la hidrología y la pérdida de suelo. Tesis Doctoral, Universidad de Alcalá, Facultad de Ciencias, pp. 170. Garcia-Estringana, P., Alonso-Blázquez, N., Marques, M.J., Bienes, R., Alegre, J. 2010. Direct and indirect effects of Mediterranean vegetation on runoff and soil loss. European Journal of Soil Science 61, 174-185. Izzo, M., Araujo, N., Aucelli, P. P. C., Maratea, A., and Sánchez, A. 2013. Land sensitivity to Desertification in the Dominican Republic: an adaptation of the ESA methodology. Land Degradation & Development, 24: 486- 498. DOI 10.1002/ldr.2241 Lasanta, A., Cerdà, A. 2005. Long-term erosional responses after fire in the Central Spanish Pyrenees: 2. Solute release. Catena, 60, 80-101 Miao, C. Y., Yang, L., Chen, X. H., Gao, Y. 2012. The vegetation cover dynamics (1982-2006) in different erosion regions of the Yellow River Basin, China. Land Degradation & Development, 23: 62- 71. DOI 10.1002/ldr.1050 Prokop, P., Poręba, G. J. 2012. Soil erosion associated with an upland farming system under population pressure in Northeast India. Land Degradation & Development, 23: 310- 321. DOI 10.1002/ldr.2147 Zema, D. A., Bingner, R. L., Denisi, P., Govers, G., Licciardello, F., Zimbone, S. M. 2012. Evaluation of runoff, peak flow and sediment yield for events simulated by the AnnAGNPS model in a belgian agricultural watershed. Land Degradation & Development, 23: 205- 215. DOI 10.1002/ldr.1068

Realization and Addressing Analysis In Blockchain Bitcoin

NASA Astrophysics Data System (ADS)

Sakti Arief Daulay, Raja; Michrandi Nasution, Surya; Paryasto, Marisa W.

2017-11-01

The implementation research and analyze address blockchain on this bitcoin will have the results that refers to making address bitcoin a safe and boost security of address the bitcoin. The working mechanism of blockchain in making address bitcoin which is already in the blockchain system.

45 CFR 46.502 - What information must be provided when registering an IRB?

Code of Federal Regulations, 2010 CFR

2010-10-01

...) of the institution or organization operating the IRB(s); and the name, mailing address, phone number..., phone number, facsimile number, and electronic mail address of the contact person providing the... IRB's mailing address, street address (if different from the mailing address), phone number, facsimile...

27 CFR 41. 228 - Change in address.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Change in address. 41. 228..., AND PROCESSED TOBACCO Changes After Original Qualification of Importers Changes in Location Or Address § 41. 228 Change in address. Whenever any change occurs in the address, but not the location, of the...

45 CFR 46.502 - What information must be provided when registering an IRB?

Code of Federal Regulations, 2014 CFR

2014-10-01

...) of the institution or organization operating the IRB(s); and the name, mailing address, phone number..., phone number, facsimile number, and electronic mail address of the contact person providing the... IRB's mailing address, street address (if different from the mailing address), phone number, facsimile...

45 CFR 46.502 - What information must be provided when registering an IRB?

Code of Federal Regulations, 2011 CFR

2011-10-01

...) of the institution or organization operating the IRB(s); and the name, mailing address, phone number..., phone number, facsimile number, and electronic mail address of the contact person providing the... IRB's mailing address, street address (if different from the mailing address), phone number, facsimile...

45 CFR 46.502 - What information must be provided when registering an IRB?

Code of Federal Regulations, 2012 CFR

2012-10-01

...) of the institution or organization operating the IRB(s); and the name, mailing address, phone number..., phone number, facsimile number, and electronic mail address of the contact person providing the... IRB's mailing address, street address (if different from the mailing address), phone number, facsimile...

45 CFR 46.502 - What information must be provided when registering an IRB?

Code of Federal Regulations, 2013 CFR

2013-10-01

...) of the institution or organization operating the IRB(s); and the name, mailing address, phone number..., phone number, facsimile number, and electronic mail address of the contact person providing the... IRB's mailing address, street address (if different from the mailing address), phone number, facsimile...

Accessing global data from accelerator devices

DOEpatents

Bertolli, Carlo; O'Brien, John K.; Sallenave, Olivier H.; Sura, Zehra N.

2016-12-06

An aspect includes a table of contents (TOC) that was generated by a compiler being received at an accelerator device. The TOC includes an address of global data in a host memory space. The global data is copied from the address in the host memory space to an address in the device memory space. The address in the host memory space is obtained from the received TOC. The received TOC is updated to indicate that global data is stored at the address in the device memory space. A kernel that accesses the global data from the address in the device memory space is executed. The address in the device memory space is obtained based on contents of the updated TOC. When the executing is completed, the global data from the address in the device memory space is copied to the address in the host memory space.

Automatic multi-banking of memory for microprocessors

NASA Technical Reports Server (NTRS)

Wiker, G. A. (Inventor)

1984-01-01

A microprocessor system is provided with added memories to expand its address spaces beyond its address word length capacity by using indirect addressing instructions of a type having a detectable operations code and dedicating designated address spaces of memory to each of the added memories, one space to a memory. By decoding each operations code of instructions read from main memory into a decoder to identify indirect addressing instructions of the specified type, and then decoding the address that follows in a decoder to determine which added memory is associated therewith, the associated added memory is selectively enabled through a unit while the main memory is disabled to permit the instruction to be executed on the location to which the effective address of the indirect address instruction points, either before the indirect address is read from main memory or afterwards, depending on how the system is arranged by a switch.

Accessing global data from accelerator devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertolli, Carlo; O'Brien, John K.; Sallenave, Olivier H.

2016-12-06

An aspect includes a table of contents (TOC) that was generated by a compiler being received at an accelerator device. The TOC includes an address of global data in a host memory space. The global data is copied from the address in the host memory space to an address in the device memory space. The address in the host memory space is obtained from the received TOC. The received TOC is updated to indicate that global data is stored at the address in the device memory space. A kernel that accesses the global data from the address in the devicemore » memory space is executed. The address in the device memory space is obtained based on contents of the updated TOC. When the executing is completed, the global data from the address in the device memory space is copied to the address in the host memory space.« less

Pseudo-random dynamic address configuration (PRDAC) algorithm for mobile ad hoc networks

NASA Astrophysics Data System (ADS)

Wu, Shaochuan; Tan, Xuezhi

2007-11-01

By analyzing all kinds of address configuration algorithms, this paper provides a new pseudo-random dynamic address configuration (PRDAC) algorithm for mobile ad hoc networks. Based on PRDAC, the first node that initials this network randomly chooses a nonlinear shift register that can generates an m-sequence. When another node joins this network, the initial node will act as an IP address configuration sever to compute an IP address according to this nonlinear shift register, and then allocates this address and tell the generator polynomial of this shift register to this new node. By this means, when other node joins this network, any node that has obtained an IP address can act as a server to allocate address to this new node. PRDAC can also efficiently avoid IP conflicts and deal with network partition and merge as same as prophet address (PA) allocation and dynamic configuration and distribution protocol (DCDP). Furthermore, PRDAC has less algorithm complexity, less computational complexity and more sufficient assumption than PA. In addition, PRDAC radically avoids address conflicts and maximizes the utilization rate of IP addresses. Analysis and simulation results show that PRDAC has rapid convergence, low overhead and immune from topological structures.

Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor Monotherapy for Recurrent Ovarian Carcinoma

DTIC Science & Technology

2015-10-01

Monotherapy for Recurrent Ovarian Carcinoma PRINCIPAL INVESTIGATOR: Scott H. Kaufmann CONTRACTING ORGANIZATION: Mayo Clinic Rochester, MN 55905...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mayo Clinic and Foundation AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT...NUMBER 200 First St., S.W. Rochester, MN 55905 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) Mayo Clinic Rochester, MN 55905 10. SPONSOR

26 CFR 301.6212-2 - Definition of last known address.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Change of Address database that retains change of address information for thirty-six months (NCOA database). Except as provided in paragraph (b)(2)(ii) of this section, if the taxpayer's name and last... database, the new address in the NCOA database is the taxpayer's last known address, unless the IRS is...

26 CFR 301.6212-2 - Definition of last known address.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Change of Address database that retains change of address information for thirty-six months (NCOA database). Except as provided in paragraph (b)(2)(ii) of this section, if the taxpayer's name and last... database, the new address in the NCOA database is the taxpayer's last known address, unless the IRS is...

26 CFR 301.6212-2 - Definition of last known address.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Change of Address database that retains change of address information for thirty-six months (NCOA database). Except as provided in paragraph (b)(2)(ii) of this section, if the taxpayer's name and last... database, the new address in the NCOA database is the taxpayer's last known address, unless the IRS is...

26 CFR 301.6212-2 - Definition of last known address.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Change of Address database that retains change of address information for thirty-six months (NCOA database). Except as provided in paragraph (b)(2)(ii) of this section, if the taxpayer's name and last... database, the new address in the NCOA database is the taxpayer's last known address, unless the IRS is...

26 CFR 301.6212-2 - Definition of last known address.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Change of Address database that retains change of address information for thirty-six months (NCOA database). Except as provided in paragraph (b)(2)(ii) of this section, if the taxpayer's name and last... database, the new address in the NCOA database is the taxpayer's last known address, unless the IRS is...

19 CFR 10.511 - Supporting statement.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., telephone, and e-mail address (if any) of the importer of record of the good; (ii) The legal name, address, telephone, and e-mail address (if any) of the responsible official or authorized agent of the importer... this section); (iii) The legal name, address, telephone, and e-mail address (if any) of the exporter of...

40 CFR 700.17 - Addresses for the Office of Pollution Prevention and Toxics.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Addresses for the Office of Pollution... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT GENERAL Addresses § 700.17 Addresses for the Office of Pollution... non-docket materials—(1) United States Postal Service mailing address. Office of Pollution Prevention...

40 CFR 700.17 - Addresses for the Office of Pollution Prevention and Toxics.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Addresses for the Office of Pollution... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT GENERAL Addresses § 700.17 Addresses for the Office of Pollution... non-docket materials—(1) United States Postal Service mailing address. Office of Pollution Prevention...

Random domain name and address mutation (RDAM) for thwarting reconnaissance attacks

PubMed Central

Chen, Xi; Zhu, Yuefei

2017-01-01

Network address shuffling is a novel moving target defense (MTD) that invalidates the address information collected by the attacker by dynamically changing or remapping the host’s network addresses. However, most network address shuffling methods are limited by the limited address space and rely on the host’s static domain name to map to its dynamic address; therefore these methods cannot effectively defend against random scanning attacks, and cannot defend against an attacker who knows the target’s domain name. In this paper, we propose a network defense method based on random domain name and address mutation (RDAM), which increases the scanning space of the attacker through a dynamic domain name method and reduces the probability that a host will be hit by an attacker scanning IP addresses using the domain name system (DNS) query list and the time window methods. Theoretical analysis and experimental results show that RDAM can defend against scanning attacks and worm propagation more effectively than general network address shuffling methods, while introducing an acceptable operational overhead. PMID:28489910

Neuroepidemiologic Case Definition of Gulf War Illness from Neuroimaging and EEG in a Population-Representative Nested Case-Control Sample of Gulf War Veterans

DTIC Science & Technology

2017-10-01

PROJECT NUMBER 5e. TASK NUMBER E-Mail: 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING... ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and...Participants & Other Collaborating Organizations 13 8. Special Reporting Requirements 14 9. Appendices 14 4 1. INTRODUCTION: 2. KEYWORDS

Epigenetic Machinery Regulates Alternative Splicing of Androgen Receptor (AR) Gene in Castration-Resistant Prostate Cancer (CRPC)

DTIC Science & Technology

2017-09-01

Dallas, TX 75390 REPORT DATE: September 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick...AND ADDRESS(ES) 5323 Harry Hines Blvd., Dallas, TX 75390 AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER UT Southwestern Me ical Center 5323...Harry Hines Blvd., Dallas, TX 75390 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical

Opium, Insurgency, and U.S. Counterdrug Strategy in Afghanistan: A Case for Change

DTIC Science & Technology

2009-05-14

War College 686 Cushing Road Newport, RI 02841-1207 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES...CONTRACT NUMBER A Case for Change. 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT...ORGANIZATION NAME( S ) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Office of the Provost Naval

Novel Duplicate Address Detection with Hash Function

PubMed Central

Song, GuangJia; Ji, ZhenZhou

2016-01-01

Duplicate address detection (DAD) is an important component of the address resolution protocol (ARP) and the neighbor discovery protocol (NDP). DAD determines whether an IP address is in conflict with other nodes. In traditional DAD, the target address to be detected is broadcast through the network, which provides convenience for malicious nodes to attack. A malicious node can send a spoofing reply to prevent the address configuration of a normal node, and thus, a denial-of-service attack is launched. This study proposes a hash method to hide the target address in DAD, which prevents an attack node from launching destination attacks. If the address of a normal node is identical to the detection address, then its hash value should be the same as the “Hash_64” field in the neighboring solicitation message. Consequently, DAD can be successfully completed. This process is called DAD-h. Simulation results indicate that address configuration using DAD-h has a considerably higher success rate when under attack compared with traditional DAD. Comparative analysis shows that DAD-h does not require third-party devices and considerable computing resources; it also provides a lightweight security resolution. PMID:26991901

More Stamina, a Gamified mHealth Solution for Persons with Multiple Sclerosis: Research Through Design.

PubMed

Giunti, Guido; Mylonopoulou, Vasiliki; Rivera Romero, Octavio

2018-03-02

Multiple sclerosis (MS) is one of the world's most common neurologic disorders. Fatigue is one of most common symptoms that persons with MS experience, having significant impact on their quality of life and limiting their activity levels. Self-management strategies are used to support them in the care of their health. Mobile health (mHealth) solutions are a way to offer persons with chronic conditions tools to successfully manage their symptoms and problems. Gamification is a current trend among mHealth apps used to create engaging user experiences and is suggested to be effective for behavioral change. To be effective, mHealth solutions need to be designed to specifically meet the intended audience needs. User-centered design (UCD) is a design philosophy that proposes placing end users' needs and characteristics in the center of design and development, involving users early in the different phases of the software life cycle. There is a current gap in mHealth apps for persons with MS, which presents an interesting area to explore. The purpose of this study was to describe the design and evaluation process of a gamified mHealth solution for behavioral change in persons with MS using UCD. Building on previous work of our team where we identified needs, barriers, and facilitators for mHealth apps for persons with MS, we followed UCD to design and evaluate a mobile app prototype aimed to help persons with MS self-manage their fatigue. Design decisions were evidence-driven and guided by behavioral change models (BCM). Usability was assessed through inspection methods using Nielsen's heuristic evaluation. The mHealth solution More Stamina was designed. It is a task organization tool designed to help persons with MS manage their energy to minimize the impact of fatigue in their day-to-day life. The tool acts as a to-do list where users can input tasks in a simple manner and assign Stamina Credits, a representation of perceived effort, to the task to help energy management and energy profiling. The app also features personalization and positive feedback. The design process gave way to relevant lessons to the design of a gamified behavioral change mHealth app such as the importance of metaphors in concept design, negotiate requirements with the BCM constructs, and tailoring of gamified experiences among others. Several usability problems were discovered during heuristic evaluation and guided the iterative design of our solution. In this paper, we designed an app targeted for helping persons with MS in their fatigue management needs. We illustrate how UCD can help in designing mHealth apps and the benefits and challenges that designers might face when using this approach. This paper provides insight into the design process of gamified behavioral change mHealth apps and the negotiation process implied in it. ©Guido Giunti, Vasiliki Mylonopoulou, Octavio Rivera Romero. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 02.03.2018.

Photometric Studies of Rapidly Spinning Decommissioned GEO Satellites

NASA Astrophysics Data System (ADS)

Ryan, W.; Ryan, E.

A satellites general characteristics can be substantially influenced by changes in the space environment. Rapidly spinning decommissioned satellites provide an excellent opportunity to study the rotation-dependent physical processes that affect a resident space objects (RSO) spin kinematics over time. Specifically, inactive satellites at or near geosynchronous Earth-orbit (GEO) provide easy targets for which high quality data can be collected and analyzed such that small differences can be detected under single-year or less time frames. Previous workers have shown that the rotational periods of defunct GEOs have been changing over time [1]. Further, the Yarkovsky-OKeefe-Radzievskii-Paddak (YORP) effect, a phenomenon which has been well-studied in the context of the changing the spin states of asteroids, has recently been suggested to be the cause of secular alterations in the rotational period of inactive satellites [2]. Researchers at the Magdalena Ridge Observatory 2.4-meter telescope (operated by the New Mexico Institute of Mining and Technology) have been investigating the spins states of retired GEOs and other high altitude space debris since 2007 [3]. In this current work, the 2.4-meter telescope was used to track and observe the objects typically over a one- to two-hour period, repeated several times over the course of weeks. When feasible, this is then repeated on a yearly basis. Data is taken with a 1 second cadence, nominally in groups of three 600 second image sets. With the current equipment, the cadence of the image sequences is very precise while the start time is accurate only to the nearest second. Therefore, periods are determined individually using each image sequence. Repeatability of the period determination for each of these sequences is typically on the order of 0.01 second or better for objects where a single period is identified. Spin rate periods determined from the GEO light curves collected thus far have been found to range from ~3 sec to many tens of seconds. Based on these observed rotational characteristics, results will be presented on both the long- and short-term spin-rate variations of selected targets. The objective was to study a variety of satellites for rotational stability over time, and to discern how physical effects (such as YORP) might be dependent on the optical, thermal and geometrical parameters of the object. References: [1] Papushev, P., Karavaev, Y., and Mishina, M., Investigations of the evolution of optical characteristics and dynamics of proper rotation of uncontrolled geostationary artificial satellites, Advances in Space Research, 416-1422, 2009. [2] Albuja, A.A. and Scheeres, D.J., Defunct Satellites, Rotation Rates and the YORP Effect, Proceedings of the Advanced Maui Optical and Space Surveillance Technologies Conference, Wailea, Hawaii, 156-163, 2013. [3] Romero, V., W.H. Ryan, and E.V. Ryan, Monitoring Variations to the Near-Earth Space Environment during High Solar Activity using Orbiting Rocket Bodies, Proceedings of the 2007 AMOS Technical Conference, Hawaii, 389-393, 2007.

29 CFR 1402.1 - Notice of dispute.

Code of Federal Regulations, 2010 CFR

2010-07-01

... names and addresses on separate sheet in duplicate). Phone No. ______ Address of establishment affected... sheet.) (b) Employer Official to communicate with (name and title). Address:Phone No... (). Independent (). Phone No. ___. Address of local union: ________ (Street), ________ (City), ________ (State...

Mapping virtual addresses to different physical addresses for value disambiguation for thread memory access requests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gala, Alan; Ohmacht, Martin

A multiprocessor system includes nodes. Each node includes a data path that includes a core, a TLB, and a first level cache implementing disambiguation. The system also includes at least one second level cache and a main memory. For thread memory access requests, the core uses an address associated with an instruction format of the core. The first level cache uses an address format related to the size of the main memory plus an offset corresponding to hardware thread meta data. The second level cache uses a physical main memory address plus software thread meta data to store the memorymore » access request. The second level cache accesses the main memory using the physical address with neither the offset nor the thread meta data after resolving speculation. In short, this system includes mapping of a virtual address to a different physical addresses for value disambiguation for different threads.« less

Reading handprinted addresses on IRS tax forms

NASA Astrophysics Data System (ADS)

Ramanaprasad, Vemulapati; Shin, Yong-Chul; Srihari, Sargur N.

1996-03-01

The hand-printed address recognition system described in this paper is a part of the Name and Address Block Reader (NABR) system developed by the Center of Excellence for Document Analysis and Recognition (CEDAR). NABR is currently being used by the IRS to read address blocks (hand-print as well as machine-print) on fifteen different tax forms. Although machine- print address reading was relatively straightforward, hand-print address recognition has posed some special challenges due to demands on processing speed (with an expected throughput of 8450 forms/hour) and recognition accuracy. We discuss various subsystems involved in hand- printed address recognition, including word segmentation, word recognition, digit segmentation, and digit recognition. We also describe control strategies used to make effective use of these subsystems to maximize recognition accuracy. We present system performance on 931 address blocks in recognizing various fields, such as city, state, ZIP Code, street number and name, and personal names.

Increasing Capacity & Changing the Culture: Volunteer Management in Law Enforcement

DTIC Science & Technology

2009-03-01

6. AUTHOR(S) Donna Cayson 5. FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943...5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N/A 10. SPONSORING/MONITORING...mission performance in a law enforcement agency’s volunteer program? Furthermore, the research will address the role of volunteers in law enforcement

System for routing messages in a vertex symmetric network by using addresses formed from permutations of the transmission line indicees

DOEpatents

Faber, Vance; Moore, James W.

1992-01-01

A network of interconnected processors is formed from a vertex symmetric graph selected from graphs .GAMMA..sub.d (k) with degree d, diameter k, and (d+1)!/(d-k+1)! processors for each d.gtoreq.k and .GAMMA..sub.d (k,-1) with degree 3-1, diameter k+1, and (d+1)!/(d-k+1)! processors for each d.gtoreq.k.gtoreq.4. Each processor has an address formed by one of the permutations from a predetermined sequence of letters chosen a selected number of letters at a time, and an extended address formed by appending to the address the remaining ones of the predetermined sequence of letters. A plurality of transmission channels is provided from each of the processors, where each processor has one less channel than the selected number of letters forming the sequence. Where a network .GAMMA..sub.d (k,-1) is provided, no processor has a channel connected to form an edge in a direction .delta..sub.1. Each of the channels has an identification number selected from the sequence of letters and connected from a first processor having a first extended address to a second processor having a second address formed from a second extended address defined by moving to the front of the first extended address the letter found in the position within the first extended address defined by the channel identification number. The second address is then formed by selecting the first elements of the second extended address corresponding to the selected number used to form the address permutations.

Electro-opto-thermal addressing bistable and re-addressable display device based on gelator-doped liquid crystals in a poly(N-vinylcarbazole) film-coated liquid crystal cell.

PubMed

Cheng, Ko-Ting; Tang, Yi; Liu, Cheng-Kai

2016-10-03

This paper reports an electro-opto-thermal addressing bistable and re-addressable display device based on gelator-doped liquid crystals (LCs) in a poly(N-vinylcarbazole) film-coated LC cell. The bistability and re-addressability of the devices were achieved through the formation of a rubbery LC/gel mixture at room temperature. The desired patterns were addressed, erased, and re-addressed by controlling the temperature, applied voltage, and UV light illumination. Moreover, grayscales were obtained by adjusting UV light intensity. The initiation, relaxation, rise, and fall times of photoconductive poly(N-vinylcarbazole) via UV light illumination of various intensities were also examined.

Idempotent Methods for Continuous Time Nonlinear Stochastic Control

DTIC Science & Technology

2012-09-13

AND ADDRESS(ES) dba AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Stochastech Corporation dba Tempest Technologies 8939 S...Stochastic Control Problems Ben G. Fitzpatrick Tempest Technologies 8939 S. Sepulveda Boulevard, Suite 506 Los Angeles, CA 90045 Sponsored by

Geocoding rural addresses in a community contaminated by PFOA: a comparison of methods.

PubMed

Vieira, Verónica M; Howard, Gregory J; Gallagher, Lisa G; Fletcher, Tony

2010-04-21

Location is often an important component of exposure assessment, and positional errors in geocoding may result in exposure misclassification. In rural areas, successful geocoding to a street address is limited by rural route boxes. Communities have assigned physical street addresses to rural route boxes as part of E911 readdressing projects for improved emergency response. Our study compared automated and E911 methods for recovering and geocoding valid street addresses and assessed the impact of positional errors on exposure classification. The current study is a secondary analysis of existing data that included 135 addresses self-reported by participants of a rural community study who were exposed via public drinking water to perfluorooctanoate (PFOA) released from a DuPont facility in Parkersburg, West Virginia. We converted pre-E911 to post-E911 addresses using two methods: automated ZP4 address-correction software with the U.S. Postal Service LACS database and E911 data provided by Wood County, West Virginia. Addresses were geocoded using TeleAtlas, an online commercial service, and ArcView with StreetMap Premium North America NAVTEQ 2008 enhanced street dataset. We calculated positional errors using GPS measurements collected at each address and assessed exposure based on geocoded location in relation to public water pipes. The county E911 data converted 89% of the eligible addresses compared to 35% by ZP4 LACS. ArcView/NAVTEQ geocoded more addresses (n = 130) and with smaller median distance between geocodes and GPS coordinates (39 meters) than TeleAtlas (n = 85, 188 meters). Without E911 address conversion, 25% of the geocodes would have been more than 1000 meters from the true location. Positional errors in TeleAtlas geocoding resulted in exposure misclassification of seven addresses whereas ArcView/NAVTEQ methods did not misclassify any addresses. Although the study was limited by small numbers, our results suggest that the use of county E911 data in rural areas increases the rate of successful geocoding. Furthermore, positional accuracy of rural addresses in the study area appears to vary by geocoding method. In a large epidemiological study investigating the health effects of PFOA-contaminated public drinking water, this could potentially result in exposure misclassification if addresses are incorrectly geocoded to a street segment not serviced by public water.

75 FR 76426 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

..., access control lists, file system permissions, intrusion detection and prevention systems and log..., address, mailing address, country, organization, phone, fax, mobile, pager, Defense Switched Network (DSN..., address, mailing address, country, organization, phone, fax, mobile, pager, Defense Switched Network (DSN...

A Practitioner’s Guide to Trust and Legitimacy

DTIC Science & Technology

2013-09-01

7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER...9. SPONSORING /MONITORING AGENCY NAME( S ) AND ADDRESS(ES) N/A 10. SPONSORING/MONITORING AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The

Use of a Portable Stimulator to Treat GWI

DTIC Science & Technology

2015-10-01

ORGANIZATION: Veterans Biomedical Research Institute East Orange , NJ 07018 REPORT DATE: October 2015 TYPE OF REPORT: Annual Report PREPARED FOR...AND ADDRESS(ES) Veterans Biomedical Research Institute 3 385 AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER 85 Tremont Ave East Orange , NJ

77 FR 62618 - Designation of Two (2) Entities Pursuant to Executive Order 13224 of September 23, 2001...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

[email protected]yahoo.com ; alt. Email Address [email protected] ; alt. Email Address [email protected]@alquds- online.org ; alt. Email Address [email protected]yahoo.com ; alt. Email Address city.com ">info...

Assessing distribution and movement of blue catfish in Kansas reservoirs

USGS Publications Warehouse

Mather, Martha E.; Gerber, Kayla M.; Peterson, Zachary

2015-01-01

This report is organized into three chapters that address six objectives. The first chapter addresses objectives 1-3. The second chapter addresses objectives 4-5. The third chapter addresses objective 6. The objectives for the project are listed below for reference.

Modeling and Prediction of Corrosion-Fatigue Failures in AF1410 Steel Test Specimens

DTIC Science & Technology

2009-01-12

PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Structures Division, Code 4.3.3 University of Dayton Research Bldg. 2187 Room 2340A Institute Naval...AND ADDRESS(ES) Office of Naval Research One Liberty Center 875 North Randolph St., Suite 1425 Arlington, VA 22203-1995 11. SPONSOR/MONITOR’S...costs. To address these issues, NAVAIR has initiated a multiyear research program to investigate and quantify the fatigue life reduction due to

Development of novel non agoinst PPAR-gamma ligands for lung cancer treatment

DTIC Science & Technology

2017-08-01

Melin Khandekar, M.D., Ph.D. CONTRACTING ORGANIZATION : Massachusetts General Hospital Boston, MA 02114 REPORT DATE: August 2017 TYPE OF REPORT...5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Massachusetts General Hospital 55 Fruit St. Boston, MA 02114 55 AND...ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S

Hydraenidae of Madagascar (Insecta: Coleoptera).

PubMed

Perkins, Philip D

2017-11-03

The Madagascar fauna of the beetle family Hydraenidae is comprehensively revised, based on the study and databasing of 6,949 specimens. New collection records are provided for 11 previously described species, and 95 new species are described. Three new subgenera of Hydraena, viz. H. (Micromadraena), H. (Monomadraena), and H. (Dnahydnaedna) are described, and several new species groups of Hydraena are diagnosed. Two new genera in the tribe Madagastrini are described: Menomadraena and Trinomadraena. The Malagasy hydraenid fauna now comprises 106 species arrayed in the following nine genera: Aulacochthebius (2), Hydraena (65), Limnebius (10), Madagaster (8), Menomadraena (6), Ochthebius (1), Protozantaena (5), Sicilicula (8), and Trinomadraena (1). Lectotypes are designated for the following species: Aulacochthebius plicicollis (Fairmaire), 1898 (Ochthebius); Hydraena dilutipes Fairmaire, 1898; Hydraena impressicollis Fairmaire, 1898; Hydraena marginicollis Regimbart, 1903 (= Hydraena regimbarti Zaitzev 1908; nomen novum); and Ochthebius alluaudi Regimbart, 1903. Hydraena discicollis Fairmaire, 1898, is considered a nomen dubium: no type specimens were found, and the description appears to be that of a species of Aulacochthebius or Ochthebius, not Hydraena. High resolution digital images of lectotypes and holotypes of new species are presented (online versions in color). Male genitalia, representative antennae, maxillary palpi, and female terminal abdominal segments and spermathecae are illustrated. Geographic distributions of all species are mapped. Possible colonization and vicariance events are discussed at the tribal, generic and species group levels. The tribe Madagastrini, found only in Madagascar and southern India, is hygropetric, indicating that this microhabitat type has been continuously present in both Madagascar and India at least since the two separated, currently estimated to be 88 million years ago. Contrastingly, some lowland lentic species of other genera appear to be closely related to species in southern Africa, suggesting rather recent colonization events. New species of Aulacochthebius: A. perlaevis (Mahajanga, Boeny: Mahavavy Kinkony RS). New species of Hydraena (Micromadraena): H. breviceps (Fianarantsoa, 29 km SSW Ambositra, Ankazomivady); H. fortipes (Antsiranana, Forêt d' Antsahabe); H. genuvela (Antsiranana, Forêt de Binara); H. parvipalpis (Antananarivo, Réserve Spéciale d'Ambohitantely); H. rubridentata ((Mahajanga, Parc National de Namoroka); H. serripennis (Antsiranana, Forêt d' Antsahabe). New species of Hydraena (Monomadraena): H. acicula (Antsiranana, Antsaba, Galoko Mountains); H. ambohitantely (Antananarivo, Ambohitantely Spec. Res.); H. amplexa (Fianarantsoa, Andringitra NP); H. amplipunctata (Fianarantsoa, 7 km W Ranomafana); H. antsahabe (Antsiranana, Forêt d' Antsahabe); H. bergsteni (Antsiranana, Diana: Beraty); H. bisinuata (Toamasina, Tamatave 6.3 km S Ambanizona); H. bisinuloba (Toliara, Menabe: Kirindy RS.); H. bispica (Toamasina, Alaotra Mangoro: Analamazoatra SR); H. casacolumna (Fianarantsoa, Andringitra NP); H. compacta (Antananarivo, Ankaratra, Reserve Manjakatompo); H. contracolorata (Antsiranana, Montagne des Francais); H. epipleurata (Antsiranana, Forêt de Binara); H. furcula (Toliara, 40km N of Fort Dauphin, Managotry); H. gereckei (Antananarivo, Ankaratra, Reserve Manjakatompo); H. goldschmidti (Antananarivo, Anjozorobe, Ravoandrina); H. inseriata (Antananarivo, Anjozorobe, Ravoandrina); H. jubata (Antsiranana, Sava Marojejy NP); H. levifurcata (Fianarantsoa, Namarona River, 7 km SW Ranomafana); H. lubrica (Antananarivo, Ambohitantely Spec. Res.); H. mahavavona (Fianarantsoa, Ionilahy, Mahavavona); H. manjakatompo (Antananarivo, Ankaratra, Reserve Manjakatompo); H. marojejy (Antsiranana, Parc National de Marojejy); H. multiarcuata (Fianarantsoa, Ranomafana); H. oscillata (Toamasina, Alaotra Mangoro Andasibe-Mantadia NP); H. parvispinosa (Toamasina, Andasibe NP); H. pentarubra (Antsiranana, Montagne d'Ambre); H. quatriloba (Toliara, Andohahela NP, Tsimelahy); H. ranomafana (Fianarantsoa, Ranomafana); H. ravoandrina (Antananarivo, Anjozorobe, Ravoandrina); H. rubrifurcata (Antsiranana, Sava, Marojejy NP); H. sculponea (Antsiranana, Befingotra (9.2 km WSW), Res. Anjanaharibe-Sud); H. simplicata (Antsiranana, Montagne d'Ambre); H. tibiodentipes (Fianarantsoa, Andringitra NP); H. triaequalis (Fianarantsoa, Ranohira); H. tripartita (Fianarantsoa, Ranomena); H. upsilonica (Toamasina, Zahamena NP); New species of Hydraena (Hydraenopsis): H. andranomena (Toliara, Andranomena); H. arta (Antsiranana, Parc National de Marojejy); H. bucollis (Toamasina, Tamatave, Andranobe Field Station); H. clavulata (Fianarantsoa, Ranomafana); H. contorta (Antananarivo, Anjozorobe forest reserve); H. dilutipoides (Mahajanga, Parc National Tsingy de Bemaraha); H. divisa (Antsiranana, Antsaba,Galoko Mountains); H. elementaria (Antananarivo, Tamatave, Coastal lagoon); H. fulgidicollis (Antananarivo, Parc de Tsimbazaza); H. longiloba (Fianarantsoa, Madiorano); H. nanula (Antsiranana, Ankarana, Ampositelo); H. orchisa (Toamasina, Alaotra Mangoro Andasibe-Mantadia NP); H. pilobova (Antsiranana, Sava, Marojejy NP); H. pilotumida (Fianarantsoa, 7 km W Ranomafana); H. ranarilalatiani (Toamasina, Alaotra Mangoro: Analamazoatra SR); H. randriamihajai (Antsiranana, Diana: Montagne d'Ambre NP); H. renalisa (Antsiranana, Sambava: Marojejy NP); H. sinuatipes (Antsiranana, Ankarana); H. torquata (Fianarantsoa, Andringitra NP). New species of Limnebius: L. angulatus (Fianarantsoa, Namarona River, 7 km W Ranomafana); L. balkei (Antsiranana, Montagne d'Ambre); L. bergsteni (Fianarantsoa, Namarona River, 7 km W Ranomafana); L. clandestinus (Mahajanga, Boeny:Mahavavy Kinkony RSc); L. labratus (Toamasina, Maroantsetra); L. lacrimosus (Toamasina, 18.7911S 48.4259E Alaotra Mangoro Andasibe-Mantadia NP); L. lobatus (Toliara, Manakaravavy); L. maximadus (Toamasina, Alaotra Mangoro: Analamazoatra SR); L. nanostillus (Antsiranana, Ankarana); L. steineri (Fianarantsoa, 7 km W Ranomafana). New species of Madagaster: M. barbata (Fianarantsoa, Andringitra NP); M. bergsteni (Antananarivo, 18.8704S 47.6708E Analamanga); M. cataracta (Antsiranana, Sava, Marojejy NP); M. procarina (Fianarantsoa, 32 km S Ambositra); M. quadricurvipes (Fianarantsoa, Andringitra NP); M. simplissima (Fianarantsoa, 32 km S Ambositra). New species of Menomadraena: M. andringitra (Fianarantsoa, Res. Andringitra); M. concava (Fianarantsoa, R.S. Ivohibe); M. fisheri (Toliara, Enakara (11 km NW), Res. Andohahela); M. ivohibe (Fianarantsoa, R.S. Ivohibe); M. nitedula (Fianarantsoa, Res. Andringitra); M. sembella (Fianarantsoa, Amparihibe). New species of Protozantaena: P. duplicata (Antananarivo, Vakinankaratra: Manjakatompo Stn. Forestière); P. elongata (Antananarivo, Vakinankaratra: Manjakatompo Stn. Forestière). New species of Sicilicula: S. ampla (Antananarivo, Onive River near Ilempona); S. bergsteni (Fianarantsoa, 21.2263S 47.3694E, Matsiara Ambony, Ranomafana NP); S. conjugalis (Fianarantsoa, Namarona River, 7 km SW Ranomafana); S. cordicollis (Fianarantsoa, Namarona River, 7 km SW Ranomafana); S. hygropetrica (Fianarantsoa, Matsiara Ambony, Ranomafana NP); S. malagasica (Fianarantsoa, Abohimahasoa); S. sexplanata (Antsiranana, Mt. Tsaratanana). New species of Trinomadraena: T. clusa (Antsiranana, Mt. d'Ambre).

Field of Vision - Vehicles

DTIC Science & Technology

2017-05-11

NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) US Army Aberdeen Test Center (TEDT-AT-WFS) 400...AND ADDRESS(ES) Policy and Standardization Division (CSTE-TM) U.S. Army Test and Evaluation Command 2202 Aberdeen Boulevard Aberdeen Proving Ground

The Goal-Means (GM) Meta Model

DTIC Science & Technology

2009-05-01

WORK UNIT NUMBER 15 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) National Security Innovations, Inc. 8 Faneuil Hall Marketplace Boston...MA 02109 8. PERFORMING ORGANIZATION REPORT NUMBER N/A 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) AFRL/RIED 525...many  different  performers

49 CFR 107.109 - Application for renewal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... submitted by electronic mail (e-mail) to: [email protected] Electronic submissions need not be... the name, street and mailing addresses, e-mail address (if available), US DOT Registration number (if... name, street and mailing addresses, e-mail address (if available), and telephone number of an...

U.S. Policy in Pakistan as U.S. Begins to Transition Afghanistan?

DTIC Science & Technology

2012-03-14

PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Colonel Robert Mundell ... Mundell Project Adviser This SRP is submitted in partial fulfillment of the requirements of the Master of Strategic Studies Degree. The U.S

Rhetorical Genre: The Countercommencement Address as Jeremiad.

ERIC Educational Resources Information Center

King, Corwin P.

The "countercommencement" address (sometimes composed in reaction to the traditional commencement address) may be usefully criticized as an example of the rhetorical genre known as the "secular jeremiad." This provides a conceptual framework for interpreting the motives and meanings of such an address, which is typically…

[VDT worker's posture and workload in free-address office system].

PubMed

Iwakiri, Kazuyuki; Mori, Ippei; Sotoyama, Midori; Nose, Kaori; Ochiai, Takanori; Jonai, Hiroshi; Saito, Susumu

2006-01-01

A free-address system is a new office layout in which a worker can freely sit in their favorite place with a computer and materials. Since this layout has recently been introduced in offices, we conducted a questionnaire survey which aimed to clarify the effects of the free-address system on visual display terminals (VDT) workers' posture and workload. A total of 203 male VDT workers who were system engineers aged 20 to 59 using a notebook computer were evaluated, of whom 150 used the free-address layout, and 53 used the fixed-address layout. The free-address layout was effective in the improvement of individual work space compared with the fixed-address layout. Also, in this layout the worker did not feel dissatisfaction with communication or support between workers. However, workers using the free-address layout assumed an unsuitable work posture, without adjusting the height of their chairs. Furthermore, this layout might have risk factors which increase neck/shoulder and low back stiffness and/or pain. Therefore, the free-address layout may have incipient problems, and it will be necessary to examine further the effects of this layout on VDT worker's health.

47 CFR 13.10 - Licensee address.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Licensee address. 13.10 Section 13.10 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.10 Licensee address. In accordance with § 1.923 of this chapter all applications must specify an address where the...

32 CFR 516.7 - Mailing addresses.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Mailing addresses. 516.7 Section 516.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION General § 516.7 Mailing addresses. Mailing addresses for organizations referenced in...

32 CFR 516.7 - Mailing addresses.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true Mailing addresses. 516.7 Section 516.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION General § 516.7 Mailing addresses. Mailing addresses for organizations referenced in...

47 CFR 13.10 - Licensee address.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Licensee address. 13.10 Section 13.10 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.10 Licensee address. In accordance with § 1.923 of this chapter all applications must specify an address where the...

17 CFR 230.498 - Summary Prospectuses for open-end management investment companies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... [____]. (A) The legend must provide an Internet address, other than the address of the Commission's electronic filing system; toll free (or collect) telephone number; and e-mail address that investors can use to obtain the Statutory Prospectus and other information. The Internet Web site address must be...