die-ing ing proteins: Topics by Science.gov

Sample records for die-ing ing proteins

Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, Michael; Berardi, Philip; Gong Wei

The INhibitor of Growth (ING) family of plant homeodomain (PHD) proteins induce apoptosis and regulate gene expression through stress-inducible binding of phospholipids with subsequent nuclear and nucleolar localization. Relocalization occurs concomitantly with interaction with a subset of nuclear proteins, including PCNA, p53 and several regulators of acetylation such as the p300/CBP and PCAF histone acetyltransferases (HATs), as well as the histone deacetylases HDAC1 and hSir2. These interactions alter the localized state of chromatin compaction, subsequently affecting the expression of subsets of genes, including those associated with the stress response (Hsp70), apoptosis (Bax, MDM2) and cell cycle regulation (p21{sup WAF1}, cyclinmore » B) in a cell- and tissue-specific manner. The expression levels and subcellular localization of ING proteins are altered in a significant number of human cancer types, while the expression of ING isoforms changes during cellular aging, suggesting that ING proteins may play a role in linking cellular transformation and replicative senescence. The variety of functions attributed to ING proteins suggest that this tumor suppressor serves to link the disparate processes of cell cycle regulation, cell suicide and cellular aging through epigenetic regulation of gene expression. This review examines recent findings in the ING field with a focus on the functions of protein-protein interactions involving ING family members and the mechanisms by which these interactions facilitate the various roles that ING proteins play in tumorigenesis, apoptosis and senescence.« less
Function of the ING family of PHD proteins in cancer.

PubMed

Gong, Wei; Suzuki, Keiko; Russell, Michael; Riabowol, Karl

2005-05-01

The ING genes encode a family of at least seven proteins with conserved plant homeodomain (PHD)-type zinc fingers in their C-termini. The founding member, ING1, is capable of binding to and affecting the activity of histone acetyltransferase (HAT), histone deacetylase (HDAC), and factor acetyltransferase (FAT) protein complexes. Some ING proteins are involved in transcriptional regulation of genes, such as the p53-inducible genes p21 and Bax. Others have been found to affect post-translational modifications, exemplified by the ING2-induced acetylation of p53 on the same site deacetylated by the Sir2 HDAC. Upon UV irradiation, ING1 causes cell cycle arrest and interacts with proliferating cell nuclear antigen to promote DNA repair or induce apoptosis in cells to prevent tumorigenesis depending upon the severity of DNA damage. It is very likely that, by linking DNA repair, apoptosis and chromatin remodeling to the transcriptional regulation of critical genes, ING1 exerts it tumor suppressor functions by helping maintain genomic stability. Therefore, ING proteins, which are down-regulated in a broad variety of cancer types, are able to restrict cell growth and proliferation, induce apoptosis, and modulate cell cycle progression, which strongly supports the notion that ING family proteins act as class II tumor suppressors.
Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins.

PubMed

Culurgioni, Simone; Muñoz, Inés G; Moreno, Alberto; Palacios, Alicia; Villate, Maider; Palmero, Ignacio; Montoya, Guillermo; Blanco, Francisco J

2012-03-30

The protein ING4 binds to histone H3 trimethylated at Lys-4 (H3K4me3) through its C-terminal plant homeodomain, thus recruiting the HBO1 histone acetyltransferase complex to target promoters. The structure of the plant homeodomain finger bound to an H3K4me3 peptide has been described, as well as the disorder and flexibility in the ING4 central region. We report the crystal structure of the ING4 N-terminal domain, which shows an antiparallel coiled-coil homodimer with each protomer folded into a helix-loop-helix structure. This arrangement suggests that ING4 can bind simultaneously two histone tails on the same or different nucleosomes. Dimerization has a direct impact on ING4 tumor suppressor activity because monomeric mutants lose the ability to induce apoptosis after genotoxic stress. Homology modeling based on the ING4 structure suggests that other ING dimers may also exist.
ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development.

PubMed

Zhou, Lin; Wang, Pei; Zhang, Juanjuan; Heng, Boon Chin; Tong, Guo Qing

2016-02-01

ING2 (inhibitor of growth protein-2) is a member of the ING-gene family and participates in diverse cellular processes involving tumor suppression, DNA repair, cell cycle regulation, and cellular senescence. As a subunit of the Sin3 histone deacetylase complex co-repressor complex, ING2 binds to H3K4me3 to regulate chromatin modification and gene expression. Additionally, ING2 recruits histone methyltransferase (HMT) activity for gene repression, which is independent of the HDAC class I or II pathway. However, the physiological function of ING2 in mouse preimplantation embryo development has not yet been characterized previously. The expression, localization and function of ING2 during preimplantation development were investigated in this study. We showed increasing expression of ING2 within the nucleus from the 4-cell embryo stage onwards; and that down-regulation of ING2 expression by endoribonuclease-prepared small interfering RNA (esiRNA) microinjection results in developmental arrest during the morula to blastocyst transition. Embryonic cells microinjected with ING2-specific esiRNA exhibited decreased blastulation rate compared to the negative control. Further investigation of the underlying mechanism indicated that down-regulation of ING2 significantly increased expression of p21, whilst decreasing expression of HDAC1. These results suggest that ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation.
Modulators of inhibitor of growth (ING) family expression in development and disease.

PubMed

Maher, Stacey K; Helbing, Caren C

2009-05-01

The inhibitor of growth (ING) gene family proteins regulate many critical cellular processes such as cell proliferation and growth, apoptosis, DNA repair, senescence, angiogenesis, and drug resistance. Their transcripts and proteins are differentially expressed in health and disease and there is evidence for developmental regulation. The vast majority of studies have characterized ING levels in the context of cancer. However, relatively little attention has been paid to the expression of ING family members in other contexts. This review summarizes the findings from human and animal model systems that provide insight into the factors influencing the expression of these important proteins. We examine the influence of cell cycle and aging as well as genotoxic stress on ING expression levels and evaluate several emerging areas of inquiry demonstrating that ING gene activity may be modulated by factors such as the p53 tumor suppressor, DNA methylation, and ING proteins themselves with external factors such as hormones, reactive oxygen species, TGFbeta signalling, and other proteins of pathological significance also influencing ING levels. We then briefly discuss the influence of post-translational modification and changes in subcellular localization as it pertains to modulation of ING expression. Understanding how ING expression is modulated represents a vital aspect of effective drug targeting strategies.
Reduced ING1 levels in breast cancer promotes metastasis.

PubMed

Thakur, Satbir; Singla, Arvind K; Chen, Jie; Tran, Uyen; Yang, Yang; Salazar, Carolina; Magliocco, Anthony; Klimowicz, Alexander; Jirik, Frank; Riabowol, Karl

2014-06-30

INhibitor of Growth 1 (ING1) expression is repressed in breast carcinomas, but its role in breast cancer development and metastasis is unknown. ING1 levels were quantified in >500 patient samples using automated quantitative fluorescence immunohistochemistry, and data were analysed for correlations to patient outcome. Effects of altering ING levels were examined in microarrays and metastasis assays in vitro, and in a mouse metastasis model in vivo. ING1 levels were lower in tumors compared to adjacent normal breast tissue and correlated with tumor size (p=0.019) and distant recurrence (p=0.001) in ER- or Her2+ patients. In these patients ING1 predicted disease-specific and distant metastasis-free survival. Transcriptome analysis showed that the pathway most affected by ING1 was breast cancer (p = 0.0008). Decreasing levels of ING1 increased, and increasing levels decreased, migration and invasion of MDA-MB231 cells in vitro. ING1 overexpression also blocked cancer cell metastasis in vivo and eliminated tumor-induced mortality in mouse models. Our data show that ING1 protein levels are downregulated in breast cancer and for the first time, we show that altering their levels regulates metastasis in vitro and in vivo, which indicates that ING1 may have a therapeutic role for inhibiting metastasis of breast cancer.
Experimental and numerical investigations of radiation characteristics of Russian portable/compact pulsed neutron generators: ING-031, ING-07, ING-06 and ING-10-20-120

NASA Astrophysics Data System (ADS)

Chernikova, D.; Romodanov, V. L.; Belevitin, A. G.; Afanas`ev, V. V.; Sakharov, V. K.; Bogolubov, E. P.; Ryzhkov, V. I.; Khasaev, T. O.; Sladkov, A. A.; Bitulev, A. A.

2014-05-01

The present paper discusses results of full-scale experimental and numerical investigations of influence of construction materials of portable pulsed neutron generators ING-031, ING-07, ING-06 and ING-10-20-120 (VNIIA, Russia) to their radiation characteristics formed during and after an operation (shutdown period). In particular, it is shown that an original monoenergetic isotropic angular distribution of neutrons emitted by TiT target changes into the significantly anisotropic angular distribution with a broad energy spectrum stretching to the thermal region. Along with the low-energetic neutron part, a significant amount of photons appears during the operation of generators. In the pulse mode of operation of neutron generator, a presence of the construction materials leads to the "tailing" of the original neutron pulse and the appearance of an accompanying photon pulse at ~ 3 ns after the instant neutron pulse. In addition to that, reactions of neutron capture and inelastic scattering lead to the creation of radioactive nuclides, such as 58Co, 62Cu, 64Cu and 18F, which form the so-called activation radiation. Thus, the selection of a portable neutron generator for a particular type of application has to be done considering radiation characteristics of the generator itself. This paper will be of interest to users of neutron generators, providing them with valuable information about limitations of a specific generator and with recommendations for improving the design and performance of the generator as a whole.
78 FR 39023 - ING Investments, LLC, et al.;

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... portion of a Sub- Advised Series' assets, and (c) implement procedures reasonably designed to ensure that..., ING Series Fund, Inc., ING Strategic Allocation Portfolios, Inc., ING Variable Funds, ING Variable... Investment Company may offer one or more series of shares (each a ``Series'' and collectively, ``Series...
ING3 promotes prostate cancer growth by activating the androgen receptor.

PubMed

Nabbi, Arash; McClurg, Urszula L; Thalappilly, Subhash; Almami, Amal; Mobahat, Mahsa; Bismar, Tarek A; Binda, Olivier; Riabowol, Karl T

2017-05-16

The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target lysine acetyltransferase or lysine deacetylase complexes to the histone H3K4Me3 mark of active transcription, to affect chromatin structure and gene expression. ING3 is a stoichiometric member of the TIP60 lysine acetyltransferase complex implicated in prostate cancer development. Biopsies of 265 patients with prostate cancer were stained for ING3, pan-cytokeratin, and DNA. LNCaP and C4-2 androgen-responsive cells were used for in vitro assays including immunoprecipitation, western blotting, Luciferase reporter assay and quantitative polymerase chain reaction. Cell viability and migration assays were performed in prostate cancer cell lines using scrambled siRNA or siRNA targeting ING3. We find that ING3 levels and AR activity positively correlate in prostate cancer. ING3 potentiates androgen effects, increasing expression of androgen-regulated genes and androgen response element-driven reporters to promote growth and anchorage-independent growth. Conversely, ING3 knockdown inhibits prostate cancer cell growth and invasion. ING3 activates the AR by serving as a scaffold to increase interaction between TIP60 and the AR in the cytoplasm, enhancing receptor acetylation and translocation to the nucleus. Activation is independent of ING3's ability to target the TIP60 complex to H3K4Me3, identifying a previously unknown chromatin-independent cytoplasmic activity for ING3. In agreement with in vitro observations, analysis of The Cancer Genome Atlas (TCGA) data (n = 498) and a prostate cancer tissue microarray (n = 256) show that ING3 levels are higher in aggressive prostate cancers, with high levels of ING3 predicting shorter patient survival in a low AR subgroup. Including ING3 levels with currently used indicators such as the Gleason score provides more
Structural Insight Into Histone Recognition by the ING PHD Fingers

PubMed Central

Champagne, Karen S.; Kutateladze, Tatiana G.

2009-01-01

The Inhibitor of Growth (ING) tumor suppressors are implicated in oncogenesis, control of DNA damage repair, cellular senescence and apoptosis. All members of the ING family contain unique amino-terminal regions and a carboxy-terminal plant homeodomain (PHD) finger. While the amino-terminal domains associate with a number of protein effectors including distinct components of histone deacetylase (HDAC) and histone acetyltransferase (HAT) complexes, the PHD finger binds strongly and specifically to histone H3 trimethylated at lysine 4 (H3K4me3). In this review we describe the molecular mechanism of H3K4me3 recognition by the ING1-5 PHD fingers, analyze the determinants of the histone specificity and compare the biological activities and structures within subsets of PHD fingers. The atomic-resolution structures of the ING PHD fingers in complex with a H3K4me3 peptide reveal that the histone tail is bound in a large and deep binding site encompassing nearly one-third of the protein surface. An extensive network of intermolecular hydrogen bonds, hydrophobic and cation-π contacts, and complementary surface interactions coordinate the first six residues of the H3K4me3 peptide. The trimethylated Lys4 occupies an elongated groove, formed by the highly conserved aromatic and hydrophobic residues of the PHD finger, whereas the adjacent groove accommodates Arg2. The two grooves are connected by a narrow channel, the small size of which defines the PHD finger’s specificity, excluding interactions with other modified histone peptides. Binding of the ING PHD fingers to H3K4me3 plays a critical role in regulating chromatin acetylation. The ING proteins function as tethering molecules that physically link the HDAC and HAT enzymatic complexes to chromatin. In this review we also highlight progress recently made in understanding the molecular basis underlying biological and tumorigenic activities of the ING tumor suppressors. PMID:19442115
Negative Regulation of NF-κB by the ING4 Tumor Suppressor in Breast Cancer

PubMed Central

Byron, Sara A.; Min, Elizabeth; Thal, Tanya S.; Hostetter, Galen; Watanabe, Aprill T.; Azorsa, David O.; Little, Tanya H.; Tapia, Coya; Kim, Suwon

2012-01-01

Nuclear Factor kappa B (NF-κB) is a key mediator of normal immune response but contributes to aggressive cancer cell phenotypes when aberrantly activated. Here we present evidence that the Inhibitor of Growth 4 (ING4) tumor suppressor negatively regulates NF-κB in breast cancer. We surveyed primary breast tumor samples for ING4 protein expression using tissue microarrays and a newly generated antibody. We found that 34% of tumors expressed undetectable to low levels of the ING4 protein (n = 227). Tumors with low ING4 expression were frequently large in size, high grade, and lymph node positive, suggesting that down-regulation of ING4 may contribute to breast cancer progression. In the same tumor set, we found that low ING4 expression correlated with high levels of nuclear phosphorylated p65/RelA (p-p65), an activated form of NF-κB (p = 0.018). Fifty seven percent of ING4-low/p-p65-high tumors were lymph node-positive, indicating a high metastatic tendency of these tumors. Conversely, ectopic expression of ING4 inhibited p65/RelA phosphorylation in T47D and MCF7 breast cancer cells. In addition, ING4 suppressed PMA-induced cell invasion and NF-κB-target gene expression in T47D cells, indicating that ING4 inhibited NF-κB activity in breast cancer cells. Supportive of the ING4 function in the regulation of NF-κB-target gene expression, we found that ING4 expression levels inversely correlated with the expression of NF-κB-target genes in primary breast tumors by analyzing public gene expression datasets. Moreover, low ING4 expression or high expression of the gene signature composed of a subset of ING4-repressed NF-κB-target genes was associated with reduced disease-free survival in breast cancer patients. Taken together, we conclude that ING4 negatively regulates NF-κB in breast cancer. Consequently, down-regulation of ING4 leads to activation of NF-κB, contributing to tumor progression and reduced disease-free patient survival in breast cancer. PMID
Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.

PubMed

Berger, Penny L; Winn, Mary E; Miranti, Cindy K

2017-01-01

How prostate epithelial cells differentiate and how dysregulation of this process contributes to prostate tumorigenesis remain unclear. We recently identified a Myc target and chromatin reader protein, ING4, as a necessary component of human prostate luminal epithelial cell differentiation, which is often lost in primary prostate tumors. Furthermore, loss of ING4 in the context of oncogenic mutations is required for prostate tumorigenesis. Identifying the gene targets of ING4 can provide insight into how its loss disrupts differentiation and leads to prostate cancer. Using a combination of RNA-Seq, a best candidate approach, and chromatin immunoprecipitation (ChIP), we identified Miz1 as a new ING4 target. ING4 or Miz1 overexpression, shRNA knock-down, and a Myc-binding mutant were used in a human in vitro differentiation assay to assess the role of Miz1 in luminal cell differentiation. ING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation. Miz1 mRNA was not induced in shING4 expressing cells or tumorigenic cells in which ING4 is not expressed. Miz1 dependency on ING4 was unique to differentiating luminal cells; Miz1 mRNA expression was not induced in basal cells. Although Miz1 is a direct target of ING4, and its overexpression can drive luminal cell differentiation, Miz1 was not required for differentiation. Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation although it is not absolutely required. Prostate 77:49-59, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression.

PubMed

Gong, Wei; Russell, Michael; Suzuki, Keiko; Riabowol, Karl

2006-04-01

ING1 is a type II tumor suppressor that affects cell growth, stress signaling, apoptosis, and DNA repair by altering chromatin structure and regulating transcription. Decreased ING1 expression is seen in several human cancers, and mislocalization has been noted in diverse types of cancer cells. Aberrant targeting may, therefore, functionally inactivate ING1. Bioinformatics analysis identified a sequence between the nuclear localization sequence and plant homeodomain domains of ING1 that closely matched the binding motif of 14-3-3 proteins that target cargo proteins to specific subcellular locales. We find that the widely expressed p33(ING1b) splicing isoform of ING1 interacts with members of the 14-3-3 family of proteins and that this interaction is regulated by the phosphorylation status of ING1. 14-3-3 binding resulted in significant amounts of p33(ING1b) protein being tethered in the cytoplasm. As shown previously, ectopic expression of p33(ING1b) increased levels of the p21(Waf1) cyclin-dependent kinase inhibitor upon UV-induced DNA damage. Overexpression of 14-3-3 inhibited the up-regulation of p21(Waf1) by p33(ING1b), consistent with the idea that mislocalization blocks at least one of ING1's biological activities. These data support the idea that the 14-3-3 proteins play a crucial role in regulating the activity of p33(ING1b) by directing its subcellular localization.
LACEwING: A New Moving Group Analysis Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riedel, Adric R.; Blunt, Sarah C.; Faherty, Jacqueline K.

We present a new nearby young moving group (NYMG) kinematic membership analysis code, LocAting Constituent mEmbers In Nearby Groups (LACEwING), a new Catalog of Suspected Nearby Young Stars, a new list of bona fide members of moving groups, and a kinematic traceback code. LACEwING is a convergence-style algorithm with carefully vetted membership statistics based on a large numerical simulation of the Solar Neighborhood. Given spatial and kinematic information on stars, LACEwING calculates membership probabilities in 13 NYMGs and three open clusters within 100 pc. In addition to describing the inputs, methods, and products of the code, we provide comparisons ofmore » LACEwING to other popular kinematic moving group membership identification codes. As a proof of concept, we use LACEwING to reconsider the membership of 930 stellar systems in the Solar Neighborhood (within 100 pc) that have reported measurable lithium equivalent widths. We quantify the evidence in support of a population of young stars not attached to any NYMGs, which is a possible sign of new as-yet-undiscovered groups or of a field population of young stars.« less
Co-Story-ing: Collaborative Story Writing with Children Who Fear

ERIC Educational Resources Information Center

Pehrsson, Dale-Elizabeth

2007-01-01

This article offers a guide for using collaborative story writing (co-story-ing), an assessment technique as well as a therapeutic intervention for children who demonstrate fears, extreme shyness and difficulty in establishing relationships. Co-story-ing draws from Gardner's Mutual Story Telling Technique. Co-story-ing guides clients as they…
LIGHT-ing Up Prostate Cancer for Immunotherapy

DTIC Science & Technology

2016-10-01

Award Number: W81XWH-15-1-0491 TITLE: LIGHT -ing up prostate cancer for immunotherapy PRINCIPAL INVESTIGATOR: W. Martin Kast, Ph.D...FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2016 2. REPORT TYPE Annual 3. DATES COVERED 4. TITLE AND SUBTITLE LIGHT -ing up prostate cancer...expression of LIGHT molecules within the tumor milieu counteracts cancer immune-evasion mechanisms and instigates activation and migration of T-cells
A personal memoir of Inge Lehmann (1888-1993)

NASA Astrophysics Data System (ADS)

Simon, Ruth

On February 21, the world lost a pioneering woman scientist and I lost a treasured friend.I met Inge Lehmann in the 1950s when she came to Lamont to work on her “Lg” paper. We immediately became friends despite the large difference in our ages. Her quiet dignity, her interest in everything scientific and feminine, her desire to learn all she could about our lives in and out of the observatory astounded me. Inge was shy, almost painfully so. Dr. Ewing arranged for Inge to stay in the guest house where she could do her work and have assistance as needed. One of my most pleasant duties to make her feel at home was to take her on weekly trips to the supermarket. She prepared her own meals in her guest house quarters. I shopped for my own family at the same time, leaving my provisions in the car until it was time to go home after work. Inge kept ice cream and frozen food in her small freezer for me.
78 FR 18634 - ING Life Insurance and Annuity Company, et al; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... SECURITIES AND EXCHANGE COMMISSION [Release No. IC-30431; File No. 812-14033] ING Life Insurance... (the ``1940 Act'' or ``Act''). APPLICANTS: ING Life Insurance and Annuity Company (``ING Life''), ING USA Annuity and Life Insurance Company (``ING USA''), ReliaStar Life Insurance Company of New York...
ING4 Loss in Prostate Cancer Progression

DTIC Science & Technology

2016-10-01

proper transitioning from late stage pregnancy to early lactation [12]. ING4 expres- sion is also lost in some breast cancers [13] where it may suppress...differentiation, Pten is elevated early (Fig. 6a), but decreases after ING4 is induced and CREB becomes active (after day 10). In EMP cells, CREB/ATF1 is...constitutive CREB/ATF1 activation (Fig. 6c) as early as 4 days after differentiation, before it is detected in normal PrECs. We observed a
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression

PubMed Central

Kumamoto, Kensuke; Fujita, Kaori; Kurotani, Reiko; Saito, Motonobu; Unoki, Motoko; Hagiwara, Nobutoshi; Shiga, Hideaki; Bowman, Elise D.; Yanaihara, Nozomu; Okamura, Shu; Nagashima, Makoto; Miyamoto, Kotaro; Takenoshita, Seiichi; Yokota, Jun; Harris, Curtis C.

2009-01-01

Inhibitor of growth 2 (ING2) is associated with chromatin remodeling and regulation of gene expression by binding to a methylated histone H3K4 residue and recruiting HDAC complexes to the region. The aim of our study is to investigate the regulation of ING2 expression and the clinical significance of upregulated ING2 in colon cancer. Here, we show that the ING2 mRNA level in colon cancer tissue increased to more than twice than that in normal mucosa in the 45% of colorectal cancer cases that we examined. A putative NF-κB binding site was found in the ING2 promoter region. We confirmed that NF-κB could bind to the ING2 promoter by EMSA and luciferase assays. Subsequent microarray analyses revealed that ING2 upregulates expression of matrix metalloproteinase 13 (MMP13), which enhances cancer invasion and metastasis. ING2 regulation of MMP13 expression was confirmed in both ING2 overexpression and knock down experiments. MMP13 expression was further induced by coexpression of ING2 with HDAC1 or with mSin3A, suggesting that the ING2-HDAC1-mSin3A complex members regulates expression of MMP13. In vitro invasion assay was performed to determine functional significance of ING2 upregulation. ING2 overexpressed cells exhibited greater invasive potential. Taken together, upregulation of ING2 was associated with colon cancer and MMP13-dependent cellular invasion, indicating that ING2 expression might be involved with cancer invasion and metastasis. PMID:19437536

The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chin, M.Y.; Ng, Kin Cheung P.; Li Gang

The roles of p33ING2 as a tumor suppressor candidate have been shown through regulation of gene transcription, induction of cell cycle arrest, and apoptosis. As p33ING2 shares 58.9% homology with p33ING1b, we hypothesized that p33ING2 shares functional similarities with p33ING1b. We previously found that p33ING1b cooperates with p53 to enhance UVB-induced apoptosis. Here, we report that overexpression of p33ING2 enhanced apoptosis in UVB-irradiated and non-irradiated melanoma MMRU cells. We demonstrate that enhancement of apoptosis by p33ING2 requires the presence of functional p53. Furthermore, we found that overexpression of p33ING2 significantly downregulated the expression of Bcl-2 after UVB irradiation, resulting inmore » an increased Bax/Bcl-2 ratio. Moreover, we found that p33ING2 promoted Bax translocation to mitochondria, altered the mitochondrial membrane potential, and induced cytochrome c release and thus the activation of caspases 9 and 3. In addition, we showed that under non-stress conditions p33ING2 upregulates Fas expression and activates caspase 8. Taken together, we demonstrate that p33ING2 cooperates with p53 to regulate apoptosis via activation of both the mitochondrial/intrinsic and death-receptor/extrinsic apoptotic pathways.« less
75 FR 65620 - Inglis Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

... Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting Comments...: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The project would be... ready for environmental analysis at this time. l. The proposed 2.0-megawatt Inglis Hydropower Project...
Idiopathic nodular glomerulosclerosis (ING) in an African American (AA) man with hepatitis C.

PubMed

Onteddu, Nirmal K; Duggirala, Jayasri; Reddy, Anand C

2018-05-18

Idiopathic nodular glomerulosclerosis (ING) in a non-diabetic patient is uncommon. Nodular glomerulosclerosis is hallmark sign of diabetic nephropathy. ING is a very rare clinicopathological disease associated with smoking, obesity and hypertension, chronic obstructive pulmonary disease and metabolic syndrome. A 68-year-old non-obese African American man with hypertension, smoking and history of hepatitis C presented to the clinic with progressive worsening of lower extremity oedema and declining renal function over few months. Renal biopsy demonstrated nodular glomerulosclerosis. In this case, ING is hypothesised to be associated with hepatitis C along with smoking and hypertension (HTN). We present this case to speculate the existence of yet unknown aetiologies of ING. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Green(ing) English: Voices Howling in the Wilderness?

ERIC Educational Resources Information Center

Bruce, Heather E.

2011-01-01

The relatively new fields of ecocriticism in literary studies and ecocomposition in rhetoric and composition studies provide a usable foundation for those interested in green(ing) English. Nevertheless, even suggesting that interest in the environment within English studies is a relatively new concern is somewhat misleading. Contemplation of…
[The mechanism of inhibition effect of adenovirus-mediated ING4 on human lung adenocarcinoma xenografts in nude mice].

PubMed

Huang, Jinhong; Yang, Jicheng; Ling, Chunhua; Zhao, Daguo; Xie, Yufeng; You, Zhenhua

2014-02-01

The inhibitor of growth 4 (ING4) is an important tumor suppressive gene.It has been proven that ING4 could inhibite the proliferation of many tumors. e aim of this study is to investigate the inhibitory effect and anti-cancer mechanism of adenovirus-mediated ING4 gene on SPC-A1 human lung adenocarcinoma in nude mice. A human lung adenocarcinoma xenograft model was established with SPC-A1 cells in nude mice. A total of 15 tumor-bearing nude mice were randomly divided into three groups, namely, PBS, Ad-GFP, and Ad-ING4. e mice in the three groups were intratumorally injected every other day. Their tumor volumes were continually recorded. The treatment tumors were then removed from the mice and weighed. Tumor inhibition rates were calculated. Cell apoptosis was examined by TUNEL method. Caspase-3, COX-2, Fas, and FasL expressions were investigated by immunohistochemistry SP assay. Both tumor weight and volume in the Ad-ING4 group were significantly decreased. The tumor inhibition rate of the mice in the Ad-ING4 group (33.17% ± 5.24%) was statistically different from that of the mice in the Ad-GFP group (1.31% ± 0.31%; P<0.05). The apoptotic index of the mice in the Ad-ING4 group (69.23% ± 6.53%) was also significantly different from those in PBS (17.04% ± 1.10%) and Ad-GFP groups (18.81% ± 1.93%; P<0.05). Based on immunohistochemistry SP assay, the results showed that Ad-ING4 may not only upregulate the expressions of caspase-3, Fas, and FasL but also downregulate the expression of COX-2. ING4 gene elicited a remarkable growth inhibitory e-ect on human lung adenocarcinoma xenografts in nude mice. e mechanism is possibly related to an increase in tumor cell apoptosis.
Yb7Ni4InGe12: a quaternary compound having mixed valent Yb atoms grown from indium flux.

PubMed

Subbarao, Udumula; Jana, Rajkumar; Chondroudi, Maria; Balasubramanian, Mahalingam; Kanatzidis, Mercouri G; Peter, Sebastian C

2015-03-28

The new intermetallic compound Yb7Ni4InGe12 was obtained as large silver needle shaped single crystals from reactive indium flux. Single crystal X-ray diffraction suggests that Yb7Ni4InGe12 crystallizes in the Yb7Co4InGe12 structure type, and tetragonal space group P4/m and lattice constants are a = b = 10.291(2) Å and c = 4.1460(8) Å. The crystal structure of Yb7Ni4InGe12 consists of columnar units of three different types of channels filled with the Yb atoms. The crystal structure of Yb7Ni4InGe12 is closely related to Yb5Ni4Ge10. The effective magnetic moment obtained from the magnetic susceptibility measurements in the temperature range 200-300 K is 3.66μB/Yb suggests mixed/intermediate valence behavior of ytterbium atoms. X-ray absorption near edge spectroscopy (XANES) confirms that Yb7Ni4InGe12 exhibits mixed valence.
9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma.

PubMed

Ugolkov, Andrey V; Bondarenko, Gennadiy I; Dubrovskyi, Oleksii; Berbegall, Ana P; Navarro, Samuel; Noguera, Rosa; O'Halloran, Thomas V; Hendrix, Mary J; Giles, Francis J; Mazar, Andrew P

2018-05-25

Advanced stage neuroblastoma is a very aggressive pediatric cancer with limited treatment options and a high mortality rate. Glycogen synthase kinase-3β (GSK-3β) is a potential therapeutic target in neuroblastoma. Using immunohistochemical staining, we observed positive GSK-3β expression in 67% of human neuroblastomas (34 of 51 cases). Chemically distinct GSK-3 inhibitors (AR-A014418, TDZD-8, and 9-ING-41) suppressed the growth of neuroblastoma cells, whereas 9-ING-41, a clinically relevant small-molecule GSK-3β inhibitor with broad-spectrum preclinical antitumor activity, being the most potent. Inhibition of GSK-3 resulted in a decreased expression of the antiapoptotic molecule XIAP and an increase in neuroblastoma cell apoptosis. Mouse xenograft studies showed that the combination of clinically relevant doses of CPT-11 and 9-ING-41 led to greater antitumor effect than was observed with either agent alone. These data support the inclusion of patients with advanced neuroblastoma in clinical studies of 9-ING-41, especially in combination with CPT-11.
How Inge Lehmann Discovered the Inner Core of the Earth

ERIC Educational Resources Information Center

Rousseau, Christiane

2013-01-01

The mathematics behind Inge Lehmann's discovery that the inner core of the Earth is solid is explained using data collected around the Earth on seismic waves and their travel time through the Earth.
75 FR 10230 - Inglis Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting Motions To...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting Motions To Intervene and Protests... No.: P-12783-003. c. Date filed: July 22, 2009. d. Applicant: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The proposed project would be located at the existing...
Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: first evidence in preclinical hepatocellular carcinoma.

PubMed

Galal El-Shemi, A; Mohammed Ashshi, A; Oh, E; Jung, B-K; Basalamah, M; Alsaegh, A; Yun, C-O

2018-01-01

Current treatments of hepatocellular carcinoma (HCC) are ineffective and unsatisfactory in many aspects. Cancer-targeting gene virotherapy using oncolytic adenoviruses (OAds) armed with anticancer genes has shown efficacy and safety in clinical trials. Nowadays, both inhibitor of growth 4 (ING4), as a multimodal tumor suppressor gene, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as a potent apoptosis-inducing gene, are experiencing a renaissance in cancer gene therapy. Herein we investigated the antitumor activity and safety of mono- and combined therapy with OAds armed with ING4 (Ad-ΔB/ING4) and TRAIL (Ad-ΔB/TRAIL) gene, respectively, on preclinical models of human HCC. OAd-mediated expression of ING4 or TRAIL transgene was confirmed. Ad-ΔB/TRAIL and/or Ad-ΔB/ING4 exhibited potent killing effect on human HCC cells (HuH7 and Hep3B) but not on normal liver cells. Most importantly, systemic therapy with Ad-ΔB/ING4 plus Ad-ΔB/TRAIL elicited more eradicative effect on an orthotopic mouse model of human HCC than their monotherapy, without causing obvious overlapping toxicity. Mechanistically, Ad-ΔB/ING4 and Ad-ΔB/TRAIL were remarkably cooperated to induce antitumor apoptosis and immune response, and to repress tumor angiogenesis. This is the first study showing that concomitant therapy with Ad-ΔB/ING4 and Ad-ΔB/TRAIL may provide a potential strategy for HCC therapy and merits further investigations to realize its possible clinical translation.
ING4 Loss in Prostate Cancer Progression

DTIC Science & Technology

2015-10-01

determine how loss of ING4 in patients relates to tumor progression. We found the following: 1) Notch3 is a target of Myc required for differentiation. 2...hour doxycycline-treated MKK6 cells. Figure 1: Notch3 induction requires Myc. A. MKK6 was induced in PrECs with a 4 hour doxycycline (Dox) pulse...Levels of MKK6, p38α, active p38α (p-p38α), Myc, Notch3 (full length (FL) or cleaved (TM), and GAPDH over time (hours (h)) measured by
SCFJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer

PubMed Central

Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng

2015-01-01

Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1–Cul1–F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCFJFK as a bona fide E3 ligase for ING4 and unraveled the JFK–ING4–NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. PMID:25792601
75 FR 16456 - Inglis Hydropower, LLC; Notice Soliciting Scoping Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... would be located at the existing Inglis Bypass Channel and Spillway on the Withlacoochee River, west of... Bypass Channel; (2) a 130-foot-long penstock consisting of two 14-foot by 14- foot reinforced concrete... megawatt (MW) and one 0.4 MW vertical shaft turbines; (4) a 100-foot-long concrete discharge channel...
77 FR 74245 - ING Investments, LLC, et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... Investments, LLC (``IIL''), Directed Services LLC (``DSL'') and ING Investment Management Co. LLC (``IIM..., at (202) 551-6821 (Division of Investment Management, Office of Investment Company Regulation..., N.V. 2. Each Registrant is registered under the Act as an open-end management investment company...
SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

PubMed

Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng

2015-03-15

Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1-Cul1-F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. © 2015 Yan et al.; Published by Cold Spring Harbor Laboratory Press.
MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, XueLi, E-mail: zhangxueli.200010@yahoo.com.cn; Zhu, WeiYing; Zhang, JiFa

2010-04-30

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in human gastric cancer progression has been reported; however, the role of miR-650 in gastric cancer is poorly understood. In this study, we show that miR-650 is involved in lymphatic and distant metastasis in human gastric cancer, and we find that ectopic expression of miR-650 promotes tumorigenesis and proliferation of gastric cancer cells. A luciferase reporter assay demonstrates that Inhibitor of Growth 4 (ING4) is a direct target of miR-650. Collectively, our study demonstrates that over-expression of miR-650 in gastric cancer may promotemore » proliferation and growth of cancer cells, at least partially through directly targeting ING4. These findings help clarify the molecular mechanisms involved in gastric carcinogenesis and indicate that miR-650 modulation may be a bona fide miRNA-based treatment of gastric cancer.« less
BE-ing @Work: Wearables and Presence of Mind in the Workplace

ERIC Educational Resources Information Center

Forbes Oste, Heidi

2016-01-01

Expectations and demands in the changing contemporary workplace are driven by emergent technologies. Ubiquitous in nature, they are designed to enhance human and organization potential. These technologies provide access to information and connection at all times. They are increasingly reliant on human relationships and connection. BE-ing one's…
On Mathematicians' Proof Skimming: A Reply to Inglis and Alcock

ERIC Educational Resources Information Center

Weber, Keith; Mejia-Ramos, Juan Pablo

2013-01-01

n a recent article, Inglis and Alcock (2012) contended that their data challenge the claim that when mathematicians validate proofs, they initially skim a proof to grasp its main idea before reading individual parts of the proof more carefully. This result is based on the fact that when mathematicians read proofs in their study, on average their…
Queer(y)ing and Recrafting Agency: Moving Away from a Model of Coercion versus Escape

ERIC Educational Resources Information Center

Gowlett, Christina

2014-01-01

This paper applies a Butlerian-inspired "queer(y)ing" methodology to disrupt the utility of agency being framed within the binary of escape and coercion. In particular, it uses Butler's concept of performative resignification to analyse how Simon, a 16-year-old white male student, maneouvres his way through the social conventions of…
76 FR 54770 - Public Meeting: Notification by Capital One Financial Corporation, McLean, VA, To Acquire ING...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-02

... FEDERAL RESERVE SYSTEM Public Meeting: Notification by Capital One Financial Corporation, McLean, VA, To Acquire ING Bank, FSB, Wilmington, DE, and Indirectly To Acquire Shares of Sharebuilder... Reserve System. ACTION: Notice of public meeting. SUMMARY: Three public meetings will be held regarding...

Reflections on the Grammatical Category of "Before" "After" and "Since" Introducing Non-Finite "-ing" Clauses: A Corpus Approach

ERIC Educational Resources Information Center

He, Qingshun

2016-01-01

English language learners may be confused in identifying the grammatical category of such conjunctive expressions as "before," "after" and "since" introducing non-finite "-ing" clauses. In this article, we will conduct a corpus-based investigation of hypotactic conjunctions and conjunctive prepositions…
Dahlen Receives 2003 Inge Lehmann Medal

NASA Astrophysics Data System (ADS)

Nolet, Guust; Dahlen, Francis A., Jr.

2004-01-01

``I feel honored and pleased to cite my friend and Princeton colleague Tony Dahlen for the Inge Lehmann medal. Given Tony's wide range of important contributions, there is actually a choice of AGU honors one might cite him for; his influence extends well beyond those fields that are primarily associated with the Lehmann Medal. ``Tony started his scientific journey as an undergraduate at Caltech. By the time he moved on to graduate studies with George Backus and Freeman Gilbert at Scripps he was already applying his many talents to geophysics. He soon pioneered a series of papers on normal modes that represent the first substantial step away from Earth's spherical symmetry. In fact, all of the current research on the use of low-frequency seismic data for the determination of the Earth's three-dimensional structure is based on this early work, its extension to an inverse problem, and subsequent research with Martin Smith and John Woodhouse. His interest in the theory of global tomography has survived until this day: Recently he developed a very elegant and efficient theory to include the frequency-dependent effects of diffraction into body wave tomography, a theoretical improvement that was almost immediately rewarded by the imaging of a large number of mantle plumes. These represent the first concrete seismological evidence that many hot spots originate deep in the mantle, confirming Jason Morgan's long-standing hypothesis.
Queer(y)ing New Schooling Accountabilities through "My School": Using Butlerian Tools to Think Differently about Policy Performativity

ERIC Educational Resources Information Center

Gowlett, Christina

2015-01-01

This article takes the role of provocateur to "queer(y)" the rules of intelligibility surrounding new schooling accountabilities. Butler's work is seldom used outside the arena of gender and sexualities research. A "queer(y)ing" methodology is subsequently applied in a context very different to where it is frequently…
Complete genome sequence of Peptoniphilus sp. strain ING2-D1G isolated from a mesophilic lab-scale completely stirred tank reactor utilizing maize silage in co-digestion with pig and cattle manure for biomethanation.

PubMed

Tomazetto, Geizecler; Hahnke, Sarah; Maus, Irena; Wibberg, Daniel; Pühler, Alfred; Schlüter, Andreas; Klocke, Michael

2014-12-20

The bacterium Peptoniphilus sp. strain ING2-D1G (DSM 28672), a mesophilic and obligate anaerobic bacterium belonging to the order Clostridiales was isolated from a biogas-producing lab-scale completely stirred tank reactor (CSTR) optimized for anaerobic digestion of maize silage in co-fermentation with pig and cattle manure. In this study, the whole genome sequence of Peptoniphilus sp. strain ING2-D1G, a new isolate potentially involved in protein breakdown and acidogenesis during biomass degradation, is reported. The chromosome of this strain is 1.6Mb in size and encodes genes predicted to be involved in the production of acetate, lactate and butyrate specifying the acidogenic metabolism of the isolate. Copyright © 2014 Elsevier B.V. All rights reserved.
CeasIng Cpap At standarD criteriA (CICADA): predicting a successful outcome.

PubMed

Yin, Yue; Broom, Margaret; Wright, Audrey; Hovey, Donna; Abdel-Latif, Mohamed E; Shadbolt, Bruce; Todd, David A

2016-01-01

This is a retrospective analysis of a multicentre randomised controlled trial (RCT) where we concluded that CeasIng Cpap At standerD criteriA (CICADA) in premature babies (PBs) <30 weeks gestational age (GA) was the significantly better method of ceasing CPAP. To identify factors that may influence the number of attempts to cease CPAP, we reviewed the records of 50 PBs from the RCT who used the CICADA method. PBs were grouped according to number of attempts to cease CPAP (fast group ≤2 attempts and slow group >2 attempts to cease CPAP). There were 26 (fast group) and 24 (slow group) PBs included in the analysis. Results showed significant differences in mean GA (27.8 ± 0.3 vs 26.9 ± 0.3 [weeks ± SE], p = 0.03) and birth weight ([Bwt]; 1080 ± 48.8 vs 899 ± 45.8 [grams ± SE], p = 0.01) between groups. Significantly fewer PBs in the fast group had a patent ductus arteriosus (PDA) compared to the slow group (5/26 (19.2%) vs 13/24 (54.2 %), p = 0.02). Bwt was a significant negative predictor of CPAP duration (r = -0.497, p = 0.03) and CPAP ceasing attempts (r = -0.290, p = 0.04). PBs with a higher GA and Bwt without a PDA ceased CPAP earlier using the CICADA method. Bwt was better than GA for predicting CPAP duration and attempts to cease CPAP. Our previous studies showed that CeasIng Cpap At standarD criteriA (CICADA) significantly reduces CPAP time, oxygen requirements and caffeine use. Some PBs however using the CICADA method required >2 attempts to cease CPAP ('slow CICADA' group). PBs in the 'fast CICADA' group (<3 attempts to cease CPAP) (a) have longer gestational age and higher birth weight, (b) shorter mechanical ventilation and (c) lower incidence of patent ductus arteriosus. Attempts to cease CPAP decreased by 0.5 times per 1 week increase in GA and 0.3 times per 100-g increase in birth weight for PBs <30 weeks gestation.
The ING observatory in the 2015-2025 decade

NASA Astrophysics Data System (ADS)

Balcells, M.

2015-05-01

The Isaac Newton Group, after nearly 30 years of productive operation of the William Herschel, Isaac Newton and Jacobus Kapteyn telescopes, is reviewing its science focus. The central goal is to respond to the changes in the astronomical landscapes in UK, the Netherlands, and especially in Spain, now a mature world-player community with access to 10-m class telescopes on La Palma and Paranal. The current model, which exploits scientific and instrumentation diversity, will continue to be offered until 2017. In the meantime, an ING-led consortium is building WEAVE, a next-generation spectroscopic facility for the WHT. WEAVE is a multi-fibre system capable of deploying either 1000 single-fibre probes, 25 mini-IFUs or a single large IFU, to feed a two-arm bench spectrograph which delivers resolving powers of either 5000 or 20,000. WEAVE will exploit a new field corrector at the WHT that enlarges the prime-focus FOV diameter from the current 40 arcmin to 2 degrees. WEAVE will be used to carry out massive surveys that exploit Gaia data in topics of Milky Way astronomy and stellar evolution; surveys that carry out galaxy evolution studies linked to various multi-wavelength surveys, including the LOFAR radio telescope; and redshift surveys of distant galaxies for cosmology. Community fibres will be available. The expectation is that these surveys will use 70% of the WHT time until at least 2022. The rest of the time will be available via normal TAC allocations, for use of facility instrumentation. Plans for the INT include involving external institutions in the provision of new instrumentation and/or telescope upgrades in exchange for significant fractions of telescope time.
Running injuries and associated factors in participants of ING Taipei Marathon.

PubMed

Chang, Wei-Ling; Shih, Yi-Fen; Chen, Wen-Yin

2012-08-01

To investigate the distribution of lower extremity running injuries and their associated factors. Descriptive and exploratory study. 1004 participants of the 2005 ING Taipei International Marathon. We used a self-developed questionnaire to collect data of previous running injuries and applied multivariate logistic regression modeling to examine relationships between these injuries and associated factors. Of the 893 valid questionnaires, 396 (44.4%) reported having previous lower extremity pain related to running. Knee joint pain was the most common problem (32.5%). Hip pain was associated with the racing group, training duration, and medial arch support. Use of knee orthotics (P = 0.002) and ankle braces (P = 0.007) was related to a higher rate of knee and ankle pain. Participants of the full marathon group who practiced on a synthetic track had a higher incidence of ankle pain. A training duration of >60 min was linked to an increased rate of foot pain (P = 0.003). Our data indicated that running injuries were associated with training duration and use of orthotics. Clinicians can use this information in treating or preventing running associated injuries and pain. Copyright © 2011 Elsevier Ltd. All rights reserved.
Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.

PubMed

Zhao, Shuang; Yang, Xue-Feng; Gou, Wen-Feng; Lu, Hang; Li, Hua; Zhu, Zhi-Tu; Sun, Hong-Zhi; Zheng, Hua-Chuan

2016-02-01

Inhibitor of growth protein 2 (ING2) has an important role in the regulation of chromatin remodeling, cell proliferation, cell‑cycle arrest, senescence and apoptosis. The present study performed an immunohistochemical analysis for expression profiling of ING2 protein in an array of tissues comprising normal mouse and human tissues, as well as human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung (n=192) carcinoma tissues. In mouse tissues, ING2 was detected in the nuclei and cytoplasm of the glandular epithelium of breast, hepatocytes, intestine, bronchium and alveoli, as well as the squamous epithelium of skin and glomeruli, and in myocardial cells, while it was located in the cytoplasm of renal tubules and striated muscle cells. ING2 protein was scattered in the brain and spleen. In human tissues, ING2 protein was principally distributed in the cytoplasm, while in it was present in the cytoplasm and nuclei in the stomach, intestine, cervix, endometrium trachea, breast and pancreas. The nuclear location of ING2 in the stomach was more prominent than that in the cytoplasm. High ING2 immunoreactivity was detected in the tongue, stomach, skin, pancreas, cervix and breast, whereas weakly in the brain stem, thymus, thyroid, lung, striated muscle, testis, bladder and ovary. In total, 617 out of 1,194 of the tested cancer tissues (51.7%) were ING2-positive. In most cases, ING2 expression was found to be restricted to the cytoplasm of all cancer tissues, while in certain cancer types, including renal clear cell, ovarian and colorectal carcinoma, it was occasionally present in the nuclei. Among the cancer tissues examined, ING2 was most frequently expressed in breast cancer (67.4%) and gynecological cancer types, including ovarian cancer (61.5%) and endometrial cancer (57.3%). Compared with
Mapping the social impacts of small dams: The case of Thailand's Ing River basin.

PubMed

Fung, Zali; Pomun, Teerapong; Charles, Katrina J; Kirchherr, Julian

2018-05-24

The social impacts of large dams have been studied extensively. However, small dams' social impacts have been largely neglected by the academic community. Our paper addresses this gap. We examine the social impacts of multiple small dams in one upstream and one downstream village in Thailand's Ing River basin. Our research is based on semi-structured interviews with beneficiaries, government and NGOs. We argue that small dams' social impacts are multi-faceted and unequal. The dams were perceived to reduce fish abundance and provide flood mitigation benefits. Furthermore, the dams enabled increased access to irrigation water for upstream farmers, who re-appropriated water via the dams at the expense of those downstream. The small dams thus engendered water allocation conflicts. Many scholars, practitioners and environmentalists argue that small dams are a benign alternative to large dams. However, the results of our research mandate caution regarding this claim.
Astrophysics on the Edge: New Instrumental Developments at the ING

NASA Astrophysics Data System (ADS)

Santander-García, M.; Rodríguez-Gil, P.; Tulloch, S.; Rutten, R. G. M.

Present and future key instruments at the Isaac Newton Group of Telescopes (ING) are introduced, and their corresponding latest scientific highlights are presented. GLAS (Ground-layer Laser Adaptive optics System): The recently installed 515 nm laser, mounted on the WHT (William Herschel Telescope), produces a bright artificial star at a height of 15 km. This enables almost full-sky access to Adaptive Optics observations. Recent commissioning observations with the NAOMI+GLAS system showed that very significant improvement in image quality can be obtained, e.g. down to 0.16 arcsec in the H band. QUCAM2 and QUCAM3: Two Low Light Level (L3) CCD cameras for fast or faint-object spectroscopy with the twin-armed ISIS spectrograph at the WHT. Their use opens a new window of high time-frequency observations, as well as access to fainter objects. They are powerful instruments for research on compact objects such as white dwarfs, neutron stars or black holes, stellar pulsations, and compact binaries.HARPS-NEF (High-Accuracy Radial-velocity Planet Searcher of the New Earths Facility): An extremely stable, high-resolution (R ˜ 120, 000) spectrograph for the WHT which is being constructed for commissioning in 2009-2010. Its radial velocity stability of < 1 m s- 1 may in the future be even further improved by using a Fabry-Perot laser-comb, a wavelength calibration unit capable of achieving an accuracy of 1 cm s- 1. This instrument will effectively allow to search for earth-like exoplanets.
East/West Perspectives on Education for Peace and Security. Conference Report of the International Network for Global Education (INGE) (New Paltz, New York, November 8-12, 1986).

ERIC Educational Resources Information Center

Global Perspectives in Education, Inc., New York, NY.

The purpose of the International Network for Global Education (INGE) is to promote global education within the educational systems of network member countries. Areas of study are listed under the following headings: Peace Studies; East/West Relations; North/South Relations; Human Rights; Global Environment; Human Values; and Cross-cultural Issues.…
S.E.E.ing the Future: Science, Engineering and Education. Commentary from the Scientific Grassroots. A White Paper on the Issues and Need for Public Funding of Basic Science and Engineering Research.

ERIC Educational Resources Information Center

Jemison, Mae C., Ed.

This document reports on the results of an ad hoc workshop called "S.E.E.ing the Future: Science Engineering and Education" Held at Dartmouth College in November of 2000 and sponsored by Dartmouth, the National Science Foundation, the Dow Chemical Company, and Science Service of Washington, DC. This transdisciplinary conference was one of a series…
An Anomaly in the Inglis-Teller Limits of the C VI Lyman and Balmer Series in Laser-Produced Plasmas

NASA Astrophysics Data System (ADS)

Elton, R.; Iglesias, E.; Griem, H.; Weaver, J.; Pien, G.; Mancini, R.

2002-11-01

Soft x-ray spectra from thin carbon layers heated by the OMEGA and NIKE lasers have been obtained with both spherical and planar targets, respectively, using a flat-field grazing incidence spectrograph equipped with a gated microchannel plate for temporal resolution. In both experiments, late-time (recombining) hydrogenic C VI spectra show an n-to-1 Lyman spectral series blending with the continuum at n=4, contrary to n=9 in the n-to-2 Balmer series. It appears unlikely that plasma inhomogeneities are the sole cause of this anomaly, given the difference in the experimental configurations. Other explanations for the line-to-continuum merging (other than the usual Stark-broadened Inglis-Teller effect) under consideration include non-thermal Doppler broadening, deviations from statistical sublevel population distributions, and opacity effects. Collisional-radiative and hydrodynamic modeling, including cascades, is employed to further understand this phenomenon.
False alarm reduction by the And-ing of multiple multivariate Gaussian classifiers

NASA Astrophysics Data System (ADS)

Dobeck, Gerald J.; Cobb, J. Tory

2003-09-01

The high-resolution sonar is one of the principal sensors used by the Navy to detect and classify sea mines in minehunting operations. For such sonar systems, substantial effort has been devoted to the development of automated detection and classification (D/C) algorithms. These have been spurred by several factors including (1) aids for operators to reduce work overload, (2) more optimal use of all available data, and (3) the introduction of unmanned minehunting systems. The environments where sea mines are typically laid (harbor areas, shipping lanes, and the littorals) give rise to many false alarms caused by natural, biologic, and man-made clutter. The objective of the automated D/C algorithms is to eliminate most of these false alarms while still maintaining a very high probability of mine detection and classification (PdPc). In recent years, the benefits of fusing the outputs of multiple D/C algorithms have been studied. We refer to this as Algorithm Fusion. The results have been remarkable, including reliable robustness to new environments. This paper describes a method for training several multivariate Gaussian classifiers such that their And-ing dramatically reduces false alarms while maintaining a high probability of classification. This training approach is referred to as the Focused- Training method. This work extends our 2001-2002 work where the Focused-Training method was used with three other types of classifiers: the Attractor-based K-Nearest Neighbor Neural Network (a type of radial-basis, probabilistic neural network), the Optimal Discrimination Filter Classifier (based linear discrimination theory), and the Quadratic Penalty Function Support Vector Machine (QPFSVM). Although our experience has been gained in the area of sea mine detection and classification, the principles described herein are general and can be applied to a wide range of pattern recognition and automatic target recognition (ATR) problems.
Enzymatic biosensors based on ingá-cipó peroxidase immobilised on sepiolite for TBHQ quantification.

PubMed

Regina de Oliveira, Tássia; Grawe, Gregory Ferreira; Moccelini, Sally Katiuce; Terezo, Ailton J; Castilho, Marilza

2014-05-07

Sepiolite clay mineral was used as a support for the immobilisation of the peroxidase enzyme from ingá-cipó (Inga edulis Mart.) and was used with graphite powder, multi-walled carbon nanotubes (CNTs), mineral oil, and nafion 0.5% (v/v) in the development of a new biosensor for the determination of the antioxidant tert-butylhydroquinone (TBHQ) by square-wave voltammetry (SWV). For the optimisation and application of the biosensor, several parameters were investigated to determine the optimum experimental conditions using SWV. The best performance was obtained using a 0.1 mol L(-1) phosphate buffer solution (pH 7.0), 4.0 × 10(-4) mol L(-1) hydrogen peroxide, a frequency of 50 Hz, a pulse amplitude of 60 mV, and a scan increment of 6 mV. The biosensor showed good repeatability and reproducibility and remained stable for a period of 20 weeks. The analytical curve revealed a linear response range of 1.65 to 9.82 mg L(-1) (r = 0.994) with detection and quantification limits of 0.41 and 1.25 mg L(-1). A recovery study of TBHQ in salad dressing samples yielded values from 99.6-104.8%. The proposed biosensor was successfully used for the determination of TBHQ in commercial salad dressing samples, giving a relative error of 5.4% in relation to the comparative method (chromatographic).
SIP-ing the elixir of youth.

PubMed

Mair, William; Steffen, Kristan K; Dillin, Andrew

2011-09-16

AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity. Copyright © 2011 Elsevier Inc. All rights reserved.
A low-protein, high-carbohydrate diet increases browning in perirenal adipose tissue but not in inguinal adipose tissue.

PubMed

Pereira, Mayara P; Ferreira, Laís A A; da Silva, Flávia H S; Christoffolete, Marcelo A; Metsios, George S; Chaves, Valéria E; de França, Suélem A; Damazo, Amílcar S; Flouris, Andreas D; Kawashita, Nair H

2017-10-01

The aim of this study was to evaluate the browning and origin of fatty acids (FAs) in the maintenance of triacylglycerol (TG) storage and/or as fuel for thermogenesis in perirenal adipose tissue (periWAT) and inguinal adipose tissue (ingWAT) of rats fed a low-protein, high-carbohydrate (LPHC) diet. LPHC (6% protein, 74% carbohydrate) or control (C; 17% protein, 63% carbohydrate) diets were administered to rats for 15 d. The tissues were stained with hematoxylin and eosin for histologic analysis. The content of uncoupling protein 1 (UCP1) was determined by immunofluorescence. Levels of T-box transcription factor (TBX1), PR domain containing 16 (PRDM16), adipose triacylglycerol lipase (ATGL), hormone-sensitive lipase, lipoprotein lipase (LPL), glycerokinase, phosphoenolpyruvate carboxykinase (PEPCK), glucose transporter 4, β 3 -adrenergic receptor (AR), β 1 -AR, protein kinase A (PKA), adenosine-monophosphate-activated protein kinase (AMPK), and phospho-AMPK were determined by immunoblotting. Serum fibroblast growth factor 21 (FGF21) was measured using a commercial kit (Student's t tests, P < 0.05). The LPHC diet increased FGF21 levels by 150-fold. The presence of multilocular adipocytes, combined with the increased contents of UCP1, TBX1, and PRDM16 in periWAT of LPHC-fed rats, suggested the occurrence of browning. The contents of β 1 -AR and LPL were increased in the periWAT. The ingWAT showed higher ATGL and PEPCK levels, phospho-AMPK/AMPK ratio, and reduced β 3 -AR and PKA levels. These findings suggest that browning occurred only in the periWAT and that higher utilization of FAs from blood lipoproteins acted as fuel for thermogenesis. Increased glycerol 3-phosphate generation by glyceroneogenesis increased FAs reesterification from lipolysis, explaining the increased TG storage in the ingWAT. Copyright © 2017 Elsevier Inc. All rights reserved.
ID’ing Innate and Innate-like Lymphoid Cells

PubMed Central

Verykokakis, Mihalis; Zook, Erin C.; Kee, Barbara L.

2014-01-01

Summary The immune system can be divided into innate and adaptive components that differ in their rate and mode of cellular activation, with innate immune cells being the first responders to invading pathogens. Recent advances in the identification and characterization of innate lymphoid cells have revealed reiterative developmental programs that result in cells with effector fates that parallel those of adaptive lymphoid cells and are tailored to effectively eliminate a broad spectrum of pathogenic challenges. However, activation of these cells can also be associated with pathologies such as autoimmune disease. One major distinction between innate and adaptive immune system cells is the constitutive expression of ID proteins in the former and inducible expression in the latter. ID proteins function as antagonists of the E protein transcription factors that play critical roles in lymphoid specification as well as B and T-lymphocyte development. In this review, we examine the transcriptional mechanisms controlling the development of innate lymphocytes, including natural killer cells and the recently identified innate lymphoid cells (ILC1, ILC2, and ILC3), and innate-like lymphocytes, including natural killer T cells, with an emphasis on the known requirements for the ID proteins. PMID:25123285
ID'ing innate and innate-like lymphoid cells.

PubMed

Verykokakis, Mihalis; Zook, Erin C; Kee, Barbara L

2014-09-01

The immune system can be divided into innate and adaptive components that differ in their rate and mode of cellular activation, with innate immune cells being the first responders to invading pathogens. Recent advances in the identification and characterization of innate lymphoid cells have revealed reiterative developmental programs that result in cells with effector fates that parallel those of adaptive lymphoid cells and are tailored to effectively eliminate a broad spectrum of pathogenic challenges. However, activation of these cells can also be associated with pathologies such as autoimmune disease. One major distinction between innate and adaptive immune system cells is the constitutive expression of ID proteins in the former and inducible expression in the latter. ID proteins function as antagonists of the E protein transcription factors that play critical roles in lymphoid specification as well as B- and T-lymphocyte development. In this review, we examine the transcriptional mechanisms controlling the development of innate lymphocytes, including natural killer cells and the recently identified innate lymphoid cells (ILC1, ILC2, and ILC3), and innate-like lymphocytes, including natural killer T cells, with an emphasis on the known requirements for the ID proteins. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
CeasIng Cpap At standarD criteriA (CICADA): impact on weight gain, time to full feeds and caffeine use.

PubMed

Broom, Margaret; Ying, Lei; Wright, Audrey; Stewart, Alice; Abdel-Latif, Mohamed E; Shadbolt, Bruce; Todd, David A

2014-09-01

In our previous randomised controlled trial (RCT), we have shown in preterm babies (PBs) <30 weeks gestation that CeasIng Cpap At standarD criteriA (CICADA (method 1)) compared with cycling off continuous positive airway pressure (CPAP) gradually (method 2) or cycling off CPAP gradually with low flow air/oxygen during periods off CPAP (method 3) reduces CPAP cessation time in PBs <30 weeks gestation. This retrospective study reviewed weight gain, time to reach full feeds and time to cease caffeine in PBs previously enrolled in the RCT. Data were collected from 162 of the 177 PBs, and there was no significant difference in the projected weight gain between the three methods. Based on intention to treat, the time taken to reach full feeds for all three methods showed no significant difference. However, post hoc analysis showed the CICADA method compared with cycling off gradually just failed significance (30.3±1.6 vs 31.1±2.4 (weeks corrected gestational age (Wks CGA±SD)), p=0.077). Analysis of time to cease caffeine showed there was a significant difference between the methods with PBs randomised to the CICADA method compared with the cycling off method ceasing caffeine almost a week earlier (33.6±2.4 vs 34.5±2.8 (Wks CGA±SD), p=0.02). This retrospective study provides evidence to substantiate the optimum method of ceasing CPAP; the CICADA method, does not adversely affect weight gain, time to reach full feeds and may reduce time to cease caffeine in PBs <30 weeks gestation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pandeló José, Diego; Bartholomeeusen, Koen; Delveccio da Cunha, Rodrigo

The ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent HIV reservoirs. Amongst the tested compounds, 3-caproyl-ingenol (ING B) was more potent in reactivating latent HIV than known activators such as SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. ING B activated PKC isoforms followed by NF-κB nuclear translocation. As virus reactivation is dependent on intact NF-κB binding sites in the LTR promoter region ING B, we have shown that. ING B was able to reactivate virus transcriptionmore » in primary HIV-infected resting cells up to 12 fold and up to 25 fold in combination with SAHA. Additionally, ING B promoted up-regulation of P-TEFb subunits CDK9/Cyclin T1. The role of ING B on promoting both transcription initiation and elongation makes this compound a strong candidate for an anti-HIV latency drug combined with suppressive HAART. - Highlights: • 3-caproyl-ingenol (ING B) reactivates latent HIV better than SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. • ING B promotes PKC activation and NF-kB translocation to the nucleus. • ING B activates virus transcription of B and non-B subtypes of HIV-1. • ING B activates HIV transcription in infected primary resting CD4+ T cells. • ING B induces higher levels of P-TEFb components in human primary cells.« less
Mapping of Monoclonal Antibody Binding Sites on CNBr Fragments of the S- Layer Protein Antigens of Rickettsia Typhi and Rickettsia Prowazekii

DTIC Science & Technology

1992-01-01

proita:ekii SPA each constitutes 10-15% of the total Research and Development Command. Research Task No cellular protein and is readily released by...modification. Selected in spaP (Carl et al., 1990). A stretch of amino acid which subsets of eucaryotic cellular proteins and bears some sequence...Publish- in procaryotes . J. Bacteriol. 170, 2891-2897. ing House of the Slovak Academy of Sciences, Bratislava. Streuli C. H. and Griffin B. E. (1987
Development and Validation of Radiation-Responsive Protein Bioassays for Biodosimetry Applications

DTIC Science & Technology

2005-01-01

radiation protein biomarker studies using an in vivo murine radiation model. Male BALB/c mice were exposed to 25-cGy 60Co- gamma radiation. Dosimetry ...Csoke, I. Hejja, An on-board TLD system for dose monitor- ing on the International Space Station, Radiation Protection Dosimetry , 84(1-4 Pt1): 321-323...diagnostic information after exposure. Using an ex vivo model system of human peripheral lymphocytes as well as an in vivo murine model, we demonstrated
CEE-ing is believing

PubMed Central

Lamb, Katrina

2011-01-01

Bioscience ventures in Central and Eastern Europe are becoming a presence in world healthcare markets despite a perennially short supply of venture funding and other support mechanisms relative to other world economic regions. Here are three up-and-coming CEE stories worth keeping an eye on. PMID:21869613
Southeast Asia Report

DTIC Science & Technology

1985-09-11

Macli-ing Dulag, and commander of the New People’s Army is . How he died is contro- versial. ..’.■. A Cordillera News Agency dispatch says...there from many places and have used all kinds of materials to build shacks there. Many of the people there are unemployed. Some have been released
Assessing and Evaluating Department of Defense Efforts to Inform, Influence, and Persuade: An Annotated Reading List

DTIC Science & Technology

2015-01-01

reading, but the read- ings in this section may be given a lower priority. Paul W. Farris, Neil T. Bendle, Phillip E. Pfeifer, and David J. Reibstein...inform, influence, and persuade. Chip Heath and Dan Heath , Made to Stick: Why Some Ideas Survive and Others Die, New York: Random House, 2007. This
A qualitative analysis of the neutron population in fresh and spent fuel assemblies during simulated interrogation using the differential die-away technique

DOE PAGES

Tobin, Stephen J.; Lundkvist, Niklas; Goodsell, Alison V.; ...

2015-12-01

In this study, Monte Carlo simulations were performed for the differential die-away (DDA) technique to analyse the time-dependent behaviour of the neutron population in fresh and spent nuclear fuel assemblies as part of the Next Generation Safeguards Initiative Spent Fuel (NGSI-SF) Project. Simulations were performed to investigate both a possibly portable as well as a permanent DDA instrument. Taking advantage of a custom made modification to the MCNPX code, the variation in the neutron population, simultaneously in time and space, was examined. The motivation for this research was to improve the design of the DDA instrument, as it is bemore » ing considered for possible deployment at the Central Storage of Spent Nuclear Fuel and Encapsulation Plant in Sweden (Clab), as well as to assist in the interpretation of the both simulated and measured signals.« less
A qualitative analysis of the neutron population in fresh and spent fuel assemblies during simulated interrogation using the differential die-away technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tobin, Stephen J.; Lundkvist, Niklas; Goodsell, Alison V.

In this study, Monte Carlo simulations were performed for the differential die-away (DDA) technique to analyse the time-dependent behaviour of the neutron population in fresh and spent nuclear fuel assemblies as part of the Next Generation Safeguards Initiative Spent Fuel (NGSI-SF) Project. Simulations were performed to investigate both a possibly portable as well as a permanent DDA instrument. Taking advantage of a custom made modification to the MCNPX code, the variation in the neutron population, simultaneously in time and space, was examined. The motivation for this research was to improve the design of the DDA instrument, as it is bemore » ing considered for possible deployment at the Central Storage of Spent Nuclear Fuel and Encapsulation Plant in Sweden (Clab), as well as to assist in the interpretation of the both simulated and measured signals.« less
77 FR 75553 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway, Biscayne Bay, and Miami River...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... allow for race participants to traverse the bridges during the ING Marathon. This deviation will result in the bridges remaining in the closed position during the ING Marathon. Tugs and tugs with tows are..., Docket Operations, telephone (202) 366-9826. SUPPLEMENTARY INFORMATION: The ING Marathon Director has...
Pulling Together in Adult Education. A History of the Scottish Institute of Adult and Continuing Education 1949-1989.

ERIC Educational Resources Information Center

Inglis, James; And Others

This document on the history of the Scottish Institute of Adult and Continuing Education (SIACE) includes seven papers as follows: "Preface" (E. Gerver); "The Beginnings 1949-1957" (J. Inglis); "The Institute under Tom Landsborough 1957-1971" (J. Inglis); "The Lean and Hungry Years 1971-1978" (J. Inglis);…
Performance Characteristics of Plane Wall Two Dimensional Diffusers

DTIC Science & Technology

1953-02-01

die Umsetzung von Wässergeschwindigkeit in Druck . Mitt. Forsch.-Arb. Geb. Ing.-Wes., Heft 76, 1909. k6 NACA TN 2888 12. Hochschild, Heinrich...Wi 0 2/ .75 ■ /5.2s A //.00 D 7.75 • 5. 3D & \\\\ /2 /e Z d, &&3 20 24 Figure 15.- Variation of pressure efficiency with divergence angle
Analysis of Leadership in Energy and Environmental Design Construction in the Air Force

DTIC Science & Technology

2012-03-01

I EQ 8.2: Day light & Views - Views for 90% of Spaces EA 1: 32% for New Buli ld ings/28% for Existing ... IEQ8.1: Daylight& Views - Dayli ght 75...Publlic ... EA 2: On-Site Renewable Energy- 1%* ID 1.5: lnnovat1ion in Design - 1 Credit* EA 1: 38% for New Buli ld ings/34% for Existing ... EA 6...Green Power MR 3: M ater ia ls Reuse: 5% • 1 Point EA 1: 34% for New Bui ld ings/3D% for Existing .. . EA 1: 36% for New Buli ld ings/32% for Existing
Modelling Situation Awareness Information for Naval Decision Support Design

DTIC Science & Technology

2003-10-01

Modelling Situation Awareness Information for Naval Decision Support Design Dr.-Ing. Bernhard Doering, Dipl.-Ing. Gert Doerfel, Dipl.-Ing... knowledge -based user interfaces. For developing such interfaces information of the three different SA levels which operators need in performing their...large scale on situation awareness of operators which is defined as the state of operator knowledge about the external environment resulting from
De Ontwikkeling van een PBPK Model voor VX; Stand van Zaken V013-813 en 207C (The Development of a PBPK Model for VX: Status Report)

DTIC Science & Technology

2006-02-01

ing. H.C. Trap, dr. ir. M.J. van der werd zes maal gesproken over de Schans, ing. L.F. Chau, B.). Lander, invulling en de voortgang van het I.A. Cordia ...dr. ir. M.J. van der Schans, ing. L.F. Chau, J.P. Oostdijk, B.J. Lander, l.A. Cordia 25 TNO Defensie en Veiligheid, vestiging Rijswijk, Marketing en
Patient advocacy and advance care planning in the acute hospital setting.

PubMed

Seal, Marion

2007-01-01

The aim of this study was to explain the role of patient advocacy in the Advance Care Planning (ACP-ing) process. Nurses rate prolonging the dying process with inappropriate measures as their most disturbing ethical issue and protecting patients' rights to be of great concern (Johnston et al 2002). Paradoxically ethical codes assume nurses have the autonomy to uphold patients' health-care choices. Advance Directives (AD) designed to improve end-of-life care are poorly taken up and acute hospitals are generally not geared for the few they receive. The Respecting Patient Choices Program (RPCP) improves AD utilisation through providing a supportive framework for ACP-ing and primarily equipping nurses as RPC consultants. Assisting patients with this process requires attributes consistent with patient advocacy arising out of nursing's most basic tenet, the care of others. Likert Scales survey administered pre and six months post-intervention to pilot and control groups, with coinciding focus groups. Selected wards in an acute care public hospital in South Australia. Nurses on the palliative care, respiratory, renal and colo-rectal pilot wards and the haem-oncology, coronary care, cardiology and neurology/geriatric control wards. The RPCP during the 2004-2005 South Australian pilot of the (RPCP). The organisational endorsement of ACP-ing gave nurses the autonomy to be patient advocates with respect to end-of-life care, reconciling clinical practice to their code of ethics and easing distress about prolonging the dying process inappropriately. Statistically significant survey results in the post-intervention group showed nurses experienced: encouragement to ensure patients could make informed choices about their end-of-life treatment (84%); the ability to uphold these wishes in practice (73%); and job satisfaction from delivering appropriate end-of-life care (67%); compared to approximately half (42-55%) of respondents in the pre-intervention and control groups. Focus
A Compendium of Arctic Environmental Information

DTIC Science & Technology

1986-03-01

warn- ing of possible future ice invasions during petroleum drill - ing operations in open-water conditions. Development of sea ice Several basic...tubes, triple beam balance snow temperature thermistor and bridge ice ttiicl^ness hand auger, electric drill with auger, tape with toggle ice...fluids, 8 quarts daily. Acidify urine by drink- ing cranberry juice, taking Vitamin C, etc. Machines All machinery in the Arctic (engines, drills
Evaluation of Resource Utilization and Treatment Patterns in Patients with Actinic Keratosis in the United States.

PubMed

Asche, Carl V; Zografos, Panagiotis; Norlin, Jenny M; Urbanek, Bill; Mamay, Carl; Makin, Charles; Erntoft, Sandra; Chen, Chi-Chang; Hines, Dionne M; Mark Siegel, Daniel

2016-01-01

To compare health care resource utilization and treatment patterns between patients with actinic keratosis (AK) treated with ingenol mebutate gel (IngMeb) and those treated with other field-directed AK therapies. A retrospective, propensity-score-matched, cohort study compared refill/repeat and adding-on/switching patterns and outpatient visits and prescriptions (health care resource utilization) over 6 months in patients receiving IngMeb versus those receiving imiquimod, 5-fluorouracil, diclofenac sodium, and methyl aminolevulinate or aminolevulinic acid photodynamic therapy (MAL/ALA-PDT). The final sample analyzed included four matched treatment cohort pairs (IngMeb and comparator; n = 790-971 per treatment arm). Refill rates were similar except for imiquimod (15% vs. 9% for imiquimod and IngMeb, respectively; P < 0.05). MAL/ALA-PDT treatment repetition rates were higher than IngMeb refill rates (20% vs. 10%; P < 0.05). Topical agent add-on/switch rates were comparable. PDT had higher switch rates than did IngMeb (5% vs. 2%; P < 0.05). The IngMeb cohort had a significantly lower proportion of patients with at least one AK-related outpatient visit during the 6-month follow-up than did any other cohort: versus imiquimod (50% vs. 66%; P < 0.0001), versus 5-fluorouracil (50% vs. 69%; P < 0.0001), versus diclofenac sodium (51% vs. 56%; P = 0.034), and versus MAL/ALA-PDT (50% vs. 100%; P < 0.0001). There were significantly fewer AK-related prescriptions among patients receiving IngMeb than among patients in other cohorts. Results based on the first 6 months after treatment initiation suggested that most field-directed AK therapies had clinically comparable treatment patterns except imiquimod, which was associated with higher refill rates, and PDT, which was associated with significantly more frequent treatment sessions and higher switching rates. IngMeb was also associated with significantly fewer outpatient visits than were other field-directed therapies. Copyright �
An Ap"peel"ing Activity

ERIC Educational Resources Information Center

Urich, Joshua A.; Sasse, Elizabeth A.

2011-01-01

This article describes a hands-on mathematics activity wherein students peel oranges to explore the surface area and volume of a sphere. This activity encourages students to make conjectures and hold mathematical discussions with both their peers and their teacher. Moreover, students develop formulas for the surface area and volume of a sphere…
DAM-ing the Digital Flood

ERIC Educational Resources Information Center

Raths, David

2008-01-01

With the widespread digitization of art, photography, and music, plus the introduction of streaming video, many colleges and universities are realizing that they must develop or purchase systems to preserve their school's digitized objects; that they must create searchable databases so that researchers can find and share copies of digital files;…
Modeling the Hydrodynamics and Water Quality of the Lower Minnesota River Using CE-QUAL-W2: A Report on the Development, Calibration, Verification, and Application of the Model

DTIC Science & Technology

2012-05-01

V3.6, allows P sorption to suspended particles and settling but does not support desorption (Cole and Wells 2008).  The OM groups in CE-QUAL-W2...model developers. Sediment transport, sediment diagenesis, phosphorus sorption , and variable algal stoichiometry were noted as potentially useful...ing Chemicals) and PPCPs ( Pharmaceut ical and Person al care Products) in receiv ing water ecosystems. He is coordinat ing this inte rnat ional

Medical Effects of Atomic Bombs. The Report of the Joint Commission for the Investigation of the Effects of the Atomic Bomb in Japan; Volume 1. Section 1. Introduction. Section 2. Physics. Section 3H. Hiroshima City. Section 3N. Nagasaki City

DTIC Science & Technology

1951-04-19

cases. The patients complained of nausea and vomit- ing on the day of the bombing and this was followed by progressive fever , anorexia, severe diarrhea... Fever and diarrhea occurred frequently and at about this same time. In the more severely affected patients, all of these symptoms appeared after a...to those seen in aplastic anemia and agranulocytosis, ]ji the most severely affected patients, fever increased steadily and those who died usually
Officer Career Development: An Overview of Analytic Concerns

DTIC Science & Technology

1989-07-01

some form of quasi-experimental analysis with nonequivalent control groups may be implemented. We shall not attempt to explic te all the variables...Development Center. 5. University of San Diego (1984, October 23-25). Pro z.ings: Volume I. Group reports. Tri-service career research workshop. San Die... design rather than a repeated measures design , where differences among diverse groups of different individuals (at different career stages) are used to
Annual Report 2010 (Rand Arroyo Center)

DTIC Science & Technology

2010-01-01

t t ing uni t S eFFeC t ively Operational tempo obviously affects maintenance require- ments for Army... oper a t ing env i r onmen t  Unconventional Warfare on the Shared Battlefi eld. Th is study identifi ed the capabilities required to success- fully...sored by the U.S. Army Training and Doctrine Command. impr ov ing C apab i l i t ie s f o r St ab i l i t y oper a t ions  Specialized
Molecular cloning, recombinant expression, and antifungal functional characterization of the lipid transfer protein from Panax ginseng.

PubMed

Cai, Kexin; Wang, Jiawen; Wang, Min; Zhang, Hui; Wang, Siming; Zhao, Yu

2016-07-01

To establish an efficient expression system for a fusion protein GST-pgLTP (Lipid Transfer Protein) and to test its antifungal activity. The nucleotide sequence of LTP gene was obtained from Panax ginseng using RT-PCR. The ORF of the cDNA is 363 bp, codING for a protein OF 120 amino acids with a calculated MW of 12.09 kDa. The pgLTP gene with a His6-tag at the C-terminus was cloned into the pGEX-6p1 vector to generate a GST-fusion pgLTP protein construct that was expressed in Escherichia coli Rosetta. Following purification by Ni-NTA, the fusion protein exhibited antifungal activity against five fungi found in ginseng. The fusion protein GST-pgLTP has activity against a broad spectrum of phytopathogenic fungi, and can potentially be adapted for production to combat fungal diseases that affect P. ginseng.
S6K1ing to ResTOR Adipogenesis with Polycomb.

PubMed

Juan, Aster H; Sartorelli, Vittorio

2016-05-05

Signal-directed chromatin recruitment of mammalian Polycomb complexes is a fundamental component of epigenetic regulation. In this issue, Yi et al. (2016) reveal how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic regulatory regions to repress expression of anti-adipogenic developmental regulators. Copyright © 2016 Elsevier Inc. All rights reserved.
Seq-ing answers: uncovering the unexpected in global gene regulation.

PubMed

Otto, George Maxwell; Brar, Gloria Ann

2018-04-19

The development of techniques for measuring gene expression globally has greatly expanded our understanding of gene regulatory mechanisms in depth and scale. We can now quantify every intermediate and transition in the canonical pathway of gene expression-from DNA to mRNA to protein-genome-wide. Employing such measurements in parallel can produce rich datasets, but extracting the most information requires careful experimental design and analysis. Here, we argue for the value of genome-wide studies that measure multiple outputs of gene expression over many timepoints during the course of a natural developmental process. We discuss our findings from a highly parallel gene expression dataset of meiotic differentiation, and those of others, to illustrate how leveraging these features can provide new and surprising insight into fundamental mechanisms of gene regulation.
Vantage point.

PubMed

Kay, Jenny

2004-06-01

'Management by expletives' sums up the new Channel 4 programme, Ramsay's Kitchen Nightmares, in which TV chef Gordon Ramsay attempts to turn around a series of failing kitchens. 'It's your f***ing kitchen,' Ramsay tells one hapless head chef, 'F***ing organise it.'
"Re-story-ing" Our Restorative Practices

ERIC Educational Resources Information Center

Rundell, Frida

2007-01-01

A metaphor for crossing a frontier into a new territory is explored. The restorative justice principles as used by the United Nations and the International Institute for Restorative Practices (IIRP) help to translate into restorative practice principles. An action research project in South Africa provides the background to an evaluation process.…
Latin America Report, No. 2678

DTIC Science & Technology

1983-05-16

Returned as Substandard (THE DAILY GLEANER, l6 Apr 83) IOU Oyster Industry Planned Over Next Year for Western Jamaica (THE DAILY GLEANER, l6 Apr 83...Fisherpond in 1 J Barbados’ oil production, now stand- i965 and ll w*s now planned to die ing at a record l 000 barrels a day <ieePer...Murray, head of the _Department of International Economic. : Co-operation in .then Ministry of Economic? / Planning and
Sympathetic denervation of one white fat depot changes norepinephrine content and turnover in intact white and brown fat depots

PubMed Central

Harris, Ruth B.S.

2013-01-01

It is well established that the sympathetic nervous system regulates adipocyte metabolism and recently it has been reported that sensory afferents from white fat overlap anatomically with sympathetic efferents to white fat. The studies described here characterize the response of intact fat pads to selective sympathectomy (local 6-hydroxydopamine injections) of inguinal (ING) or epididymal (EPI) fat in male NIH Swiss mice and provide in vivo evidence for communication between individual white and brown fat depots. The contralateral ING pad, both EPI pads, perirenal and mesenteric pads were significantly enlarged four weeks after denervating one ING pad, but only intrascapular brown fat (IBAT) increased when both ING pads were denervated. Denervation of one or both EPI pad had no effect on fat depot weights. In an additional experiment, NE turnover was inhibited in ING, retroperitoneal, mesenteric and IBAT two days after denervation of both EPI or of both ING pads. NE content was reduced to 10-30% of control values in all fat depots. There was no relation between early changes in NE turnover and fat pad weight 4 weeks after denervation, even though the reduction in NE content of intact fat pads was maintained. These data demonstrate that there is communication among individual fat pads, presumably through central integration of activity of sensory afferent and sympathetic efferent fibers,that changes sympathetic drive to white adipose tissue in a unified manner. In specific situations, removal of sympathetic efferents to one pad induces a compensatory enlargement of other intact depots. PMID:22513494
Iterative Neighbour-Information Gathering for Ranking Nodes in Complex Networks

NASA Astrophysics Data System (ADS)

Xu, Shuang; Wang, Pei; Lü, Jinhu

2017-01-01

Designing node influence ranking algorithms can provide insights into network dynamics, functions and structures. Increasingly evidences reveal that node’s spreading ability largely depends on its neighbours. We introduce an iterative neighbourinformation gathering (Ing) process with three parameters, including a transformation matrix, a priori information and an iteration time. The Ing process iteratively combines priori information from neighbours via the transformation matrix, and iteratively assigns an Ing score to each node to evaluate its influence. The algorithm appropriates for any types of networks, and includes some traditional centralities as special cases, such as degree, semi-local, LeaderRank. The Ing process converges in strongly connected networks with speed relying on the first two largest eigenvalues of the transformation matrix. Interestingly, the eigenvector centrality corresponds to a limit case of the algorithm. By comparing with eight renowned centralities, simulations of susceptible-infected-removed (SIR) model on real-world networks reveal that the Ing can offer more exact rankings, even without a priori information. We also observe that an optimal iteration time is always in existence to realize best characterizing of node influence. The proposed algorithms bridge the gaps among some existing measures, and may have potential applications in infectious disease control, designing of optimal information spreading strategies.
Non-Destructive Impermeability Testing of Land-Based Sewage Systems (zerstoerungsfreie dichtheitspruefung con grundstuecksentwaesserungsleitungen)

DTIC Science & Technology

2001-01-01

CYberdeckungsh6he zunehmen. Ffr die Stabilitdt des Str ~mungszustandes ist dagegen ein weniger empfindlicher Ansaugstutzen von Vorteil, weil geringe Schwankungen im...Gerinnestr() mung mit einem Laser-Doppler- Anemometer und einem Pitot-Rohr Ltd. BD Dipl.-Ing. B. Ftirmaier M6glichkeiten der Verwertung von HausmUll und...GrundstticksentwAsserungsleitungen ISBN 3-486-26517-2 * diese Hefte k6nnen beim Oldenbourg Industrieverlag GmbH, Rosenheimer Str . 145, 81671 MUnchen bezogen werden (Preis pro Heft: 35,00 DM, Stand 2001)
Machining Data Handbook. 3rd Edition. Volume 2

DTIC Science & Technology

1980-01-01

17.2 The power required in machining can be determined by vided in figures 17.2-3 through 17.2-10 for deternining the several different methods as...patterns and require not caused problems. and the. e have been reports of im- different methods of checking. proved die life in speial applications...microinches Ra 11.25 to 5.0 Am application of this method the surface is subjected to melt- RaJ) and wide differences in recast layer thicknesses ing
Dead and dying Brazilian free-tailed bats (Tadarida brasiliensis) from Texas: Rabies and pesticide exposure

USGS Publications Warehouse

Clark, Donlad R.; Lollar, Amanda; Cowman, Deborah

1996-01-01

Twenty-three dead and dying Brazilian free-tailed bats from roosts in downtown Mineral Wells, Palo Pinto County, Texas, were tested for rabies and for anticholinesterase (antiChE) effects of or- ganophosphorus (OP) and carbamate pesticides. Seventeen of the 23 bats tested positive for rabies. The cause of death or dying in five of the nonrabid bats is unknown; however, one of the six nonrabid bats had a ChE activity level equivalent to only 27% of the control mean and may have been exposed to a pes- ticide. Three bats (including the bat with depressed ChE) contained sufficient ingesta to analyze for an- tiChE compounds, but no antiChE compounds could be identified in the samples. Exposure may be dermal and pulmonary as well as dietary. It is feasible that other bat deaths not explained by rabies were attributable to a pesticide but missed due to postmortem reactivation of the ChE enzyme. The largest group of rabid bats was young males (13 of 17, 76.5%), and the largest group of nonrabid bats was older females (3 of 6, 50%). All older females were nonrabid, perhaps survivors of the disease in previous years. Rabid bats had a lower mean fat index and weighed less than nonrabid bats. Four bats (not includ- ing the low ChE bat) showed external bleeding, and none was rabid; thus the incidence of bleeding was greater among nonrabid bats than among rabid bats. The four affected bats came from roosts in three different buildings, making a roost-treatment with an anticoagulant chemical seem unlikely.
Advanced Integrated TPS and Non Equilibrium Chemistry Instrumentation

DTIC Science & Technology

2007-06-01

RESPECT and Dipl.-Ing. A. Preci for his contributions in the field of numerical analysis. Thanks to Dr.-Ing. Wolfgang Röck who developed the...Rhode-Saint-Genèse, Belgium, published in RTO EN-8, October 1999. [4] K. Pauly , M. Bosch, H. Schlingloff, H. Ruppe, M. Landgraf, R. Schleucher, F
Prenatal exposure to a maternal LP diet decreases BDNF expression in the brains of the neonatal offspring

USDA-ARS?s Scientific Manuscript database

Maternal low protein (LP) diets during gestation cause learning and mernmy impai1ment as well as cognitive deficits in the neonatal and adult offsp1ing. The cellular and molecular mechanism that mediate the deleterious effects of prenatal exposure to a maternal LP diet on cognitive function is egreg...
An Examination of Target Tracking in the Antisubmarine Warfare Systems Evaluation Tool (ASSET)

DTIC Science & Technology

1991-09-01

fnCorC- Ingi Ing?)))) WX CY) Calt) (dlat2 Ccosl.±sp lat2 C) (if 0- C. diet dIng? 0.0001) (proqa (if (- flag 0) (proqa (if f- ding 0) (proqa (if (c latl...x Y)) (if (or C brg 90) Cbzg 2101) fsetq rnq C- cat? dIng)) Csetq tag (abs C/ diet Cco&Lisp brgC C C Csetq rng tC 60.1077 rng)) (list rag brgC C;let...Xdus i .X KetO : 0 yea 0 0 vi : .- (-2ln(md(I ))) cod 2rad(l ( i +Xd ye n .- (-2.n(rd(I)))n 2- rnd(I ) +Ydis n ,Vet V .xp -aA 4A,- - .k .H- it .- vx
M113A1 Day/Night Movement Rate Analysis

DTIC Science & Technology

1975-06-01

d. Each vehicle traversed the course usiig the path of the preced- ing vehicle, i.e., no " free play " in selecting a route was permitted. The test...traversed the course usling the path of the preced- ing vehicle, i.e., no " free play " in selecting a route was permitted. The test course varied from
Nano-Optoelectronic Integration on Silicon

DTIC Science & Technology

2012-12-14

hole recombination, a material gain spectrum can be derived as dE EE ffM mcn e g ing in vcr r 22 0 2 2 00 2... ffM mhc en r ing in vcr r sp          (4.3) 48 Figure 4.12 Fitting spontaneous emission spectrum. The experimental
Application of Coalition Battle Management Language (C-BML) and C-BML Services to Live, Virtual, and Constructive (LVC) Simulation Environments

DTIC Science & Technology

2011-12-01

Task Based Approach to Planning.” Paper 08F- SIW -033. In Proceed- ings of the Fall Simulation Interoperability Workshop. Simulation Interoperability...Paper 06F- SIW -003. In Proceed- 2597 Blais ings of the Fall Simulation Interoperability Workshop. Simulation Interoperability Standards Organi...MSDL).” Paper 10S- SIW -003. In Proceedings of the Spring Simulation Interoperability Workshop. Simulation Interoperability Standards Organization

The Conjugation-Specific Die5 Protein Is Required for Development of the Somatic Nucleus in both Paramecium and Tetrahymena▿

PubMed Central

Matsuda, Atsushi; Shieh, Annie Wan-Yi; Chalker, Douglas L.; Forney, James D.

2010-01-01

Development in ciliated protozoa involves extensive genome reorganization within differentiating macronuclei, which shapes the somatic genome of the next vegetative generation. Major events of macronuclear differentiation include excision of internal eliminated sequences (IESs), chromosome fragmentation, and genome amplification. Proteins required for these events include those with homology throughout eukaryotes as well as proteins apparently unique to ciliates. In this study, we identified the ciliate-specific Defective in IES Excision 5 (DIE5) genes of Paramecium tetraurelia (PtDIE5) and Tetrahymena thermophila (TtDIE5) as orthologs that encode nuclear proteins expressed exclusively during development. Abrogation of PtDie5 protein (PtDie5p) function by RNA interference (RNAi)-mediated silencing or TtDie5p by gene disruption resulted in the failure of developing macronuclei to differentiate into new somatic nuclei. Tetrahymena ΔDIE5 cells arrested late in development and failed to complete genome amplification, whereas RNAi-treated Paramecium cells highly amplified new macronuclear DNA before the failure in differentiation, findings that highlight clear differences in the biology of these distantly related species. Nevertheless, IES excision and chromosome fragmentation failed to occur in either ciliate, which strongly supports that Die5p is a critical player in these processes. In Tetrahymena, loss of zygotic expression during development was sufficient to block nuclear differentiation. This observation, together with the finding that knockdown of Die5p in Paramecium still allows genome amplification, indicates that this protein acts late in macronuclear development. Even though DNA rearrangements in these two ciliates look to be quite distinct, analysis of DIE5 establishes the action of a conserved mechanism within the genome reorganization pathway. PMID:20495055
The conjugation-specific Die5 protein is required for development of the somatic nucleus in both Paramecium and Tetrahymena.

PubMed

Matsuda, Atsushi; Shieh, Annie Wan-Yi; Chalker, Douglas L; Forney, James D

2010-07-01

Development in ciliated protozoa involves extensive genome reorganization within differentiating macronuclei, which shapes the somatic genome of the next vegetative generation. Major events of macronuclear differentiation include excision of internal eliminated sequences (IESs), chromosome fragmentation, and genome amplification. Proteins required for these events include those with homology throughout eukaryotes as well as proteins apparently unique to ciliates. In this study, we identified the ciliate-specific Defective in IES Excision 5 (DIE5) genes of Paramecium tetraurelia (PtDIE5) and Tetrahymena thermophila (TtDIE5) as orthologs that encode nuclear proteins expressed exclusively during development. Abrogation of PtDie5 protein (PtDie5p) function by RNA interference (RNAi)-mediated silencing or TtDie5p by gene disruption resulted in the failure of developing macronuclei to differentiate into new somatic nuclei. Tetrahymena DeltaDIE5 cells arrested late in development and failed to complete genome amplification, whereas RNAi-treated Paramecium cells highly amplified new macronuclear DNA before the failure in differentiation, findings that highlight clear differences in the biology of these distantly related species. Nevertheless, IES excision and chromosome fragmentation failed to occur in either ciliate, which strongly supports that Die5p is a critical player in these processes. In Tetrahymena, loss of zygotic expression during development was sufficient to block nuclear differentiation. This observation, together with the finding that knockdown of Die5p in Paramecium still allows genome amplification, indicates that this protein acts late in macronuclear development. Even though DNA rearrangements in these two ciliates look to be quite distinct, analysis of DIE5 establishes the action of a conserved mechanism within the genome reorganization pathway.
ATAC-ing Transcriptional Mysteries in Malaria Parasites.

PubMed

Merrick, Catherine J

2018-04-11

Ever since Plasmodium intraerythrocytic development was reported to proceed via an unusual "hardwired" transcriptional cascade, the control of gene transcription in malaria parasites has been an area of intense investigation. In this issue of Cell Host & Microbe, Toenhake et al. (2018) illuminate this intriguing issue by applying ATAC sequencing. Copyright © 2018 Elsevier Inc. All rights reserved.
Watch-ing out for chick limb development.

PubMed

Pascoal, Susana; Palmeirim, Isabel

2007-09-01

Time control is a crucial issue during embryonic development. Nevertheless, little is known about how embryonic cells measure time. Until recently, the only molecular clock known to operate during vertebrate embryonic development was the somitogenesis clock, exclusively functioning in coordinating the precise timing of each new pair of somites formed from the presomitic mesoderm. We have recently evidenced that a similar molecular clock also underlies the timing at which autopod chondrogenic precursors are laid down to form a skeletal limb element. In addition, we herein suggest that the molecular clock is not the only parallelism that can be established between somitogenesis and limb-bud development. In an evolutionary perspective, we support the previously proposed idea that the molecular mechanisms involved in the segmentation of the body axis may have been partially reused in the mesoderm of the lateral plate, thereby allowing the emergence of paired appendages.
ADMiER-ing thin but complex fluids

NASA Astrophysics Data System (ADS)

McDonnell, Amarin G.; Bhattacharjee, Pradipto K.; Pan, Sharadwata; Hill, David; Danquah, Michael K.; Friend, James R.; Yeo, Leslie Y.; Prabhakar, Ranganathan

2011-12-01

The Acoustics Driven Microfluidic Extensional Rheometer (ADMiER) utilises micro litre volumes of liquid, with viscosities as low as that of water, to create valid and observable extensional flows, liquid bridges that pinch off due to capillary forces in this case. ADMiER allows the study fluids that have been beyond conventional methods and also study more subtle fluid properties. We can observe polymeric fluids with solvent viscosities far below those previously testable, accentuating elastic effects. Also, it has enabled the testing of aqueous solutions of living motile particles, which significantly change fluid properties, opening up the potential for diagnostic applications.
LIGHT-ing Up Prostate Cancer for Immunotherapy

DTIC Science & Technology

2017-10-01

patients with evanescent carcinoma. According to their location, they are probably IL17-producing type 3 innate lymphoid cells , which have been...with a Hamamatsu camera after performing morphometric analysis. Morphometric Analysis of Lymphoid and B Cell Follicles Lymphoid follicles (LF) were...activation, and CD8 T cell accumulation are evident in prostate tumor-associated tertiary lymphoid organs (TLO). The 5-µm thick paraffin sections
Bacteria-Phagocyte Interactions: Emerging Tactics in an Ancient Rivalry

DTIC Science & Technology

1990-01-01

afhitan. mechanisms by which microbes cvade the deposi- Mimicry of decay -accelerating factor aExample. T ’ruzi tion of immunogiobulin and complement on...their , Possible Isis of decay accelerating factor on host cell, surfaces have been well-studied (Table 2). For Example. Bacterial phospholipase example...activators of protein that mimics the action of decay accelerat- the alternate complement pathway 1171. ing factor (DAF) [261. This protein is part of a
Hypoxic regulation of the expression of cell proliferation related genes in U87 glioma cells upon inhibition of ire1 signaling enzyme

PubMed

Minchenko, O H; Tsymbal, D O; Minchenko, D O; Riabovol, O O; Ratushna, O O; Karbovskyi, L L

2016-01-01

We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and a controller of cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. It was shown that hypoxia leads to up-regulation of the expression of IL13RA2, CD24, ING1, ING2, ENDOG, and POLG genes and to down-regulation – of KRT18, TRAPPC3, TSFM, and MTIF2 genes at the mRNA level in control glioma cells. Changes for ING1 and CD24 genes were more significant. At the same time, inhibition of IRE1 modifies the effect of hypoxia on the expression of all studied genes. In particular, it increases sensitivity to hypoxia of the expression of IL13RA2, TRAPPC3, ENDOG, and PLOG genes and suppresses the effect of hypoxia on the expression of ING1 gene. Additionally, it eliminates hypoxic regulation of KRT18, CD24, ING2, TSFM, and MTIF2 genes expressions and introduces sensitivity to hypoxia of the expression of BET1 gene in glioma cells. The present study demonstrates that hypoxia, which often contributes to tumor growth, affects the expression of almost all studied genes. Additionally, inhibition of IRE1 can both enhance and suppress the hypoxic regulation of these gene expressions in a gene specific manner and thus possibly contributes to slower glioma growth, but several aspects of this regulation must be further clarified.
Assessment of Anthropometric Trends and the Effects on Thermal Regulatory Models: Females Versus Males

DTIC Science & Technology

2007-08-01

primary somatotypes , which were identified by multivariate analysis, had no significant effect on the simulated thermo-physiological responses ...population. Anthropometric values for each somatotype applied to a thermal regulatory model resulted into physiological response comparisons of Figure 2 and...Public report ing burden for this collect ion of information is est imated to average 1 hour per response , including the time for review ing instruct ions
Concluding remarks

NASA Astrophysics Data System (ADS)

Bohannan, Bruce

2001-01-01

This workshop brought proposed directions in instrumentation for the Isaac Newton Group together with scientific and technical needs of the ING astronomical community. A personal summary of the critical issues, questions, and approaches raised at this workshop includes the mission of the ING, the role of <4-m aperture telescopes today, the importance of continuous renewal, the power of AO, and the data glut.
From Onions to Shallots: Rewarding Tor Relays with TEARS

DTIC Science & Technology

2014-07-18

distributed banking using protocols from distributed digital cryp- tocurrency systems like Bitcoin . Shallots are publicly-verifiable, minimiz- ing reliance on...model; none of these have yet been implemented. In this paper, we draw upon the distributed Bitcoin architecture to design a transparent, efficient, and... Bitcoin . Shallots are publicly-veri able, minimiz- ing reliance on and trust in banking authorities, making them auditable while naturally distributing
Hazing in the U.S. Armed Forces: Recommendations for Hazing Prevention Policy and Practice

DTIC Science & Technology

2015-01-01

playing abusive tricks; threatening or oering violence or bodily harm to another; striking; branding; tattooing; shav- ing; greasing; painting...or bodily harm to another; striking; branding; tattooing; shav- ing; greasing; painting; “pinning,” “tacking on,” “blood wings”; or forcing or...particular issue for hazing denitions that address psychological, mental, or emotional harm. Specically, as one of the most thorough previous reviews of
Assessment of the Activation State of Rho Family GTP-Binding Proteins in Breast Cancer Cells and Specimens

DTIC Science & Technology

2004-08-01

AF038388 Vav3 GEF for Rho and Rac Proto-oncogene product NM020505 hPEM -2 GEF for Cdc42 Predominantly expressed in brain AB007884 GEF-H1 GEF for Rac and Rho...fence tions, and desmosomes play a fundamental role in maintain- function). A functional tight junction is crucial to maintain ing the polarized phenotype
Physiological proteins in resource-limited herbivores experiencing a population die-off

NASA Astrophysics Data System (ADS)

Garnier, R.; Bento, A. I.; Hansen, C.; Pilkington, J. G.; Pemberton, J. M.; Graham, A. L.

2017-08-01

Nutrient availability is predicted to interact with herbivore population densities. Competition for low quality food at high density may reduce summer food intake, and in turn winter survival. Conversely, low population density may favor physiological recovery through better access to better quality spring forage. Here, we take advantage of the long-term study of the Soay sheep population of St. Kilda (Scotland) to measure plasma protein markers and immunity in two consecutive summers with contrasting population densities. We show that, following a winter die-off resulting in a shift to low population density, albumin and total proteins increased, but only in adult sheep. The effect was not solely attributable to selective disappearance of malnourished sheep. Similarly, the concentration of antibodies was higher following the die-off, potentially indicating recovery of immune function. Overall, our results are consistent with the physiological recovery of surviving individuals after a harsh winter.
FY97 Materials & Processes Technology Area Plan

DTIC Science & Technology

1996-09-01

Offices ess has Center Technology Coun- ings, the first use ever of gamma (SPOs). In addition, we provide cil (CTCs) technology needs Titanium Aluminide ...300,000 in form- structive evaluation (NDE). Four Agreements (CRDAs) with 7 ing of Titanium Aluminide with Data EAchange Agreements more in negotiation and...Systems Aircraft Range with r 50% Decrease in Fuel Propulsion Syste s =Consumption Titanium Aluminides Cast Titanium 25000F Ceramic Matrix Transition
DoD Use of Commercial Acquisition Practices When They Apply and When They Do Not

DTIC Science & Technology

2015-10-01

A number of organizations—including the Defense Business Board, some think tanks and some in Congress—have encouraged or recommended greater use...simultaneously avoiding discourag- ing commercial firms from doing business with DoD by ask- ing for more information than they are willing to provide...in- vestments through In-Q-Tel and increased emphasis on the productivity of programs like the Small Business Innovative Research program. The DoD
Air Break During Preoxygenation and Risk of Altitude Decompression Sickness

DTIC Science & Technology

2010-10-01

examination and were representative of the USAF rated aircrew popula- tion. They were not allowed to participate in scuba div- ing, hyperbaric exposures, or...subjects dur- ing the hypobaric exposures and the subjects were not questioned about how they felt during the altitude ex- posures. Each subject was...to consult with the physicians in Hyperbaric Medicine within the same building. Endpoints of the exposures were: 1) comple- tion of the scheduled
JPRS Report, Science & Technology, Europe & Latin America

DTIC Science & Technology

1988-04-14

can be applied everywhere that monitoring of gaseous atmospheres is required, for example in air pollution control, monitor- ing of furnace plants ...invest a further DM50 million in develop- ing the materials and construction of a pilot plant . 2.6 Spray Process To Produce Sheet Metal Today, semi...opportunities for building small production plants that can operate economically. Initial results from this project, in which two industrial
Status of the Body of Knowledge and Curriculum to Advance Systems Engineering (BKCASE (trademark)) Project

DTIC Science & Technology

2011-10-01

Systems engineer- ing knowledge has also been documented through the standards bodies, most notably : • ISO /IEC/IEEE 15288, Systems Engineer- ing...System Life Cycle Processes, 2008 (see [10]). • ANSI/EIA 632, Processes for Engineering a System, (1998) • IEEE 1220, ISO /IEC 26702 Application...tion • United States Defense Acquisition Guidebook, Chapter 4, June 27, 2011 • IEEE/EIA 12207 , Software Life Cycle Processes, 2008 • United
Body and Surface Wave Modeling of Observed Seismic Events. Part 2.

DTIC Science & Technology

1987-05-12

is based on expand - ing the complete three dimensional solution of the wave equation expressed in cylindrical S coordinates in an asymptotic form which...using line source (2-D) theory. It is based on expand - ing the complete three dimensional solution of the wave equation expressed in cylindrical...generating synthetic point-source seismograms for shear dislocation sources using line source (2-D) theory. It is based on expanding the complete three

Lack of Evidence of Enterotoxin Involvement in Pathogenesis of Campylobacter Diarrhea

DTIC Science & Technology

1992-01-01

co/i or 1: cholerae genes encod- diarrheal disease (7, 8). but specific virulence ing enterotoxin production (29); (ii) several mechanisms are not...or watery trast to the secretory diarrhea caused by enter- stools and the absence of fever, consistent with otoxigenic E. co/i or V cholerae (21...potential of enteric host response to the toxin. Ifpresent. these find- pathogens, for many organisms, including Vibrio ings would indicate that toxinogenesis
An I for an Eye: Personal Narrative and the Great War

DTIC Science & Technology

1989-05-10

A number of good overviews of reader-response and reception theory are available: see especially Susan R. Sulieman and Inge Crosman, eds. The Reader...Reader (1987), and Robert C. Holub’s critical introduction to reception theory , Reception Theory (1984). For a recent additions to the debate, see Inge...Yale UP, 1967. Holub, Robert C. Reception Theory : A Critical Introduction. London: Metheun, 1984. 247 Hoy, David Couzens. The Critical Circle
Sleep Deprivation and Sustained Attention Performance: Integrating Mathematical and Cognitive Modeling

DTIC Science & Technology

2009-01-01

Gluck,a David F. Dingesc aAir Force Research Laboratory, Mesa bThe Pennsylvania State University , University Park cUniversity of Pennsylvania School...possible using either model- ing approach in isolation. 2.1. Biomathematical models of alertness Biomathematical models of alertness have been developed...window into the information process- ing mechanisms in the cognitive system and how they may be affected by decreased alert- ness. The next section
The International Symposium on Applied Military Psychology (21st) Held on 17-21 June 1985 in Paris, France

DTIC Science & Technology

1985-08-12

work is needed. Trainability volunteer force typically faced with tests are seen to be useful where train- recruit shortages. About half -of the ing is...women; provision for lateral ing marriage planp. It is seen as a entry; more use of a reserve status steady useful job with variation in work rather...degree to compared with other jobs. Motivatio,,i and which these motives are similar. Using satisfaction are dynamic processes rela- surveys and
Development of a Comprehensive Blast-Related Auditory Injury Database (BRAID)

DTIC Science & Technology

2016-05-01

these, may result in temporary or persistent noise-induced hear- ing loss (NIHL) and tinnitus . NIHL and tinnitus present a problematic public...uals deployed to battle zones are increasingly at risk for NIHL, tinnitus , and other otologic injuries [4]. The effects of blast exposure on the...primary interest because it may be permanent and cause persistent symptoms of tinnitus [18–20] and hear- ing loss [6,17,21–23]. Blast-related middle
Rethinking Twenty-First Century Acquisition: Emerging Trends for Efficiency Ends

DTIC Science & Technology

1997-01-01

improve the quality of their services. However, dispari- ties in current accounting methods and rules between the two sectors make evalu- ating costs ...are facilitated by the grow- ing use of ABC methods in the account - ing community. These methods tie the to- tal costs of production or services more...Acquisition program man- agers can learn by studying recent devel- opments in the private sector accounting community. Knowledge of relevant total costs and
The New Worlds Observer: The Astrophysics Strategic Mission Concept Study

DTIC Science & Technology

2009-08-01

of galaxies and galaxy clusters • Tracing the cosmic evolution of dark energy • Mapping the distribution of dark matter • Characterization of the...imaging of these fields will be used to map the distribution of dark matter us- ing the distortions of galaxy images produced by weak gravitational...dedicated to specific science goals such as mapping dark matter , tracing dark energy, or prob- ing star formation in the local Universe. In the dif
Fusion of Low-Cost Imaging and Inertial Sensors for Navigation

DTIC Science & Technology

2007-01-01

an Integrated GPS/MEMS Inertial Navigation Pack- age. In Proceedings of ION GNSS 2004, pp. 825–832, September 2004. [3] R. G. Brown and P. Y. Hwang ...track- ing, with no a priori knowledge is provided in [13]. An on- line (Extended Kalman Filter-based) method for calculat- ing a trajectory by tracking...transformation, effectively constraining the resulting correspondence search space. The algorithm was incorporated into an extended Kalman filter and
Translations on Eastern Europe Political, Sociological, and Military Affairs, Number 1364

DTIC Science & Technology

1977-03-14

Springfield, Virginia 22151. In order- ing, it is recommended that the JPRS number, title, date and author, if applicable , of publication be cited...minister of supply and state reserves issues instructions on settl- ing questions arising over the application of the decree. §3. Point 3 of the Directive...suffocating action and irritates the eyes. In using water to contain the spread of a chlorine cloud, the chlorine forms hydrochloric and hypochlorous
Telecommuting: An Altered Work Pattern.

DTIC Science & Technology

1984-09-01

TELECOMMUtTING : AN ALTERED WORK PATTERN THES IS Carole H. Smith GS -12 AFIT /GLMI/LSM/ 84S-59 Approved for public release; distribution unlimited__ , v 184...7 7.._._.._. _ ,:. . . 70-.--.- "" .._ 7." " --------- :’’ APIT/GLM/LSU/ 84s-59 TELECOMMUTING : AN ALTERED WORK PATTERN THES IS...Electronic Services Unlimited, a New York based telecommut - ing consultant company. They introduced me to telecommut - ing concepts in the private sector
State of Washington, Aquatic Plant Management Program: Design Memorandum.

DTIC Science & Technology

1979-10-01

3 days after appit- cation, fed ior 90 da- fo11-nIng haorst1ing equipment catIon. Swimming shouldt oe aplication . oring narventing opa- restricted...labor, maintenance, profit, capitalization of equipment costs, and mobilization -demobilization. 2/Local administrative costs are $2,000 for 100 acres...rental of two boats at a cost of $64/day each, mobilization - demobilization of equipment, and a capability of treating 100 acres/day. 2/The treatment boat
RT-PCR amplification of RNA extracted from formalin-fixed, paraffin-embedded oral cancer sections: analysis of p53 pathway.

PubMed

Tachibana, Masatsugu; Shinagawa, Yasuhiro; Kawamata, Hitoshi; Omotehara, Fumie; Horiuchi, Hideki; Ohkura, Yasuo; Kubota, Keiichi; Imai, Yutaka; Fujibayashi, Takashi; Fujimori, Takahiro

2003-01-01

We present a new approach towards the detection of the mRNAs in formalin-fixed, paraffin-embedded samples using a reverse transcriptase (RT)-polymerase chain reaction (PCR). The total RNAs were extracted from 10-micron-thick sections and were reverse-transcribed, then the RT-products were subjected to PCR amplification of GAPDH mRNA for screening the mRNA degradation. Next, nested PCR was performed for examining the expression of p53-related genes, p21WAF1, MDM2, p33ING1 and p14ARF. GAPDH mRNA expression was detectable in 12 out of 21 oral squamous cell carcinoma (SCC) samples. p21WAF1 mRNA expression was detectable in 5 out of 12 SCC samples, MDM2 mRNA expression was detectable in 5 our of 12 SCC samples and p33ING1 mRNA expression was detectable in 6 out of 12 SCC samples. However, the expression of p14ARF mRNA was not detectable in any of the samples. Seven out of 12 oral SCC samples showed abnormal nuclear accumulation of p53 protein by immunohistochemical staining, whereas 5 out of 12 oral SCCs showed negative staining for p53 protein. Of of p33ING1 mRNA. One of these was a verrucous carcinoma in which the p53 gene products might be inactivated by the oncoprotein E6 of human papilloma virus. Thus, the p53 tumor suppressor pathway was disrupted in most oral SCCs at the cellular levels, due to either an abnormality in p53 itself or loss of expression of p53 regulatory factors. This method would assist in making diagnosis, determining therapeutic strategy and predicting the prognosis of various cancers including oral SCCs.
MX Missile MOA Between Four Corners Regional Commission and the United States Air Force.

DTIC Science & Technology

1981-08-20

Mountains east of Beaver. The impact of hunting pres- sure and potential poaching has also ncz been addressed. 0 Despite the fact that phea- sant... impacted by both increased hunting pressure and poach - ing. Pheasant populations in the Delta area will be impacted by the loss of habitat due to...go. Water 0’ is very limiting. 4-780 1 Upland game birds will be impacted by both increased hunting pressure and poach - ing. Pheasant populations in
Military Return to Duty and Civilian Return to Work Factors Following Burns With Focus on the Hand and Literature Review

DTIC Science & Technology

2008-10-01

the three parameters of skin graft - ing, treatment time and presence of a face burn where all reports agree as to the influence of each one of these...cluding the presence of hand burns. Of the studies that agree on factor influence, five document that skin grafting had a significant effect on...stepwise multiple regression analysis, Helm et al determined TBSA to be the stron- gest predictor of RTW followed equally by skin graft - ing and hand burn
Supervisory Control: Problems, Theory and Experiment for Application to Human-Computer Interaction in Undersea Remote Systems

DTIC Science & Technology

1982-03-01

otherwise, and changes in parameters). The TIS, insofar as it has subgoals to reach, instructions ot, how to try or what to do if it is impeded...10 and 9 without affect- ing the computer (i.e. change the location, forces, labels or other properties of the display or manual control devices...sys- mode of inter • -ing with the system tem sensors, actuators and sensors, actu.-.ors and computers is computers is fixed flexible j 4. often
Sub-Saharan Africa Report, No. 2830

DTIC Science & Technology

1983-08-12

proceeds abroad and earn in- come. This scheme would require suffi- cient forex reserves. It would provide a counter revenue which could be set...also as- sisted our credit rating. Forex controls Your Money: Is there a benchmark gold price for the lifting of foreign exchange controls? Dc...first and lest it before tak- ing the next step. Your Money: The lift- ing of forex controls could lead to a vola- tile exchange rate. De Loor
2006 NRL Review

DTIC Science & Technology

2006-01-01

cool , the ink is solid and does not flow. When the cantilever is heated , the ink melts and flows from the tip onto the surface. Mov ing the tip...IBM for use in the “Millipede” memory storage system. Thermal cantilevers may be designed to give rapid heating (1 to 20 µs) and cooling (1 to 50 µs...ability of combin- ing reconfigurable hardware devices with optimization software capable of executing real-time autonomous reconfiguration opens up a
Construction Productivity Advancement Research (CPAR) Program: Improved Materials and Processes for Sealing and Resealing Joints in Portland Cement Concrete Pavements - Field Evaluation

DTIC Science & Technology

1993-10-01

sealant was determined by noting the type and number of defects each sealant incurred. Figure 4 provides a sample evaluation sheet used dur- ing the field...was conducted by visually inspect- ing the mater~al for defects . If any defects were noted, the type of defect was described and the quant~ty of that... defect was measured. The quantity of the defect was dividted by the total quantity of sealant and the result reported as percent defect . Adhesion and
The Next Generation of Synthetic Biology Chassis: Moving Synthetic Biology from the Laboratory to the Field

DTIC Science & Technology

2016-09-26

toolkit of additional promoters, RBS, and proteolysis tags to control gene expression at the transcrip- tional, translational, and protein levels. CRISPR ...synthetic promoters, high efficiency RBS, and terminators. Furthermore, the CRISPR -Cas system has been investigated for one cyanobacteria species,10 which...Development of a CRISPR -Cas9 toolkit for comprehensive engineer- ing of Bacillus subtilis. Appl. Environ. Microbiol. 82, 01159−01116. (9) Hussein, A. H
EPIC Muon Cooling Simulations using COSY INFINITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.A. Maloney, B. Erdelyi, A. Afanasev, R.P. Johnson, S.A. Bogacz, Y.S. Derbenev, V.S. Morozov

2011-03-01

Next generation magnet systems needed for cooling channels in both neutrino factories and muon colliders will be innovative and complicated. Designing, simulating and optimizing these systems is a challenge. Using COSY INFINITY, a differential algebra-based code, to simulate complicated elements can allow the computation and correction of a variety of higher order effects, such as spherical and chromatic aberrations, that are difficult to address with other simulation tools. As an example, a helical dipole magnet has been implemented and simulated, and the performance of an epicyclic parametric ionization cooling system for muons is studied and compared to simulations made usingmore » G4Beamline, a GEANT4 toolkit.« less

Adult Graduates' Negotiations of Age(ing) and Employability

ERIC Educational Resources Information Center

Siivonen, Päivi; Isopahkala-Bouret, Ulpukka

2016-01-01

In this article, we will explore Finnish adult graduates' social positioning in relation to age and ageing, and the new discursive framing of employability that is firmly expressed in national as well as in European policy agendas. Age is here understood as a social construction and ageing as a lifelong process. We will analyse our joint interview…
Boys and Music Education: "RMX"ing the Curriculum

ERIC Educational Resources Information Center

McGregor, Glenda; Mills, Martin

2006-01-01

Music is central to the lives of most high-school age boys. However, music education is a marginalised area of the school curriculum, decreasing in popularity as students approach senior school and succumb to pressures to choose subjects perceived to be more useful in the "real world". While this process is common for both boys and girls, the…
"Value"ing Children Differently? Migrant Children in Education

ERIC Educational Resources Information Center

Devine, Dympna

2013-01-01

This paper considers dilemmas around "value" and the "valuing" of children and childhood(s) in schools. I argue that in neo-liberal contexts, processes of children's identity making become aligned with the idea of the corporate citizen--value and worth derived from the capacity to produce, excel, self-regulate as well as…
Music Education Desire(ing): Language, Literacy, and Lieder

ERIC Educational Resources Information Center

Gould, Elizabeth

2009-01-01

Issues of desire in music education are integral and anathema to the profession. Constituted of and by desire, we bodily engage music emotionally and cognitively; yet references to the body are limited to how it may be better managed in order to produce more satisfactory (desired) sounds, thus disciplining desire as we focus on the content of…
Parallel Readout of Optical Disks

DTIC Science & Technology

1992-08-01

r(x,y) is the apparent reflectance function of the disk surface including the phase error. The illuminat - ing optics should be chosen so that Er(x,y...of the light uniformly illuminat - ing the chip, Ap = 474\\im 2 is the area of photodiode, and rs is the time required to switch the synapses. Figure...reference beam that is incident from the right. Once the hologram is recorded the input is blocked and the disk is illuminat - ed. Lens LI takes the
Medical Surveillance Monthly Report

DTIC Science & Technology

2016-10-01

women aged 30–70 years suffering from OSA.2 The prevalence of OSA has been ris- ing and is associated with changing obe- sity prevalence, as obesity is...information on the burden of disease in military subpopulations and the associa- tion of obesity with OSA. M E T H O D S The surveillance period for this...of the Defense Manpower Data Center), marital status, and obesity sta- tus. To calculate obese person-time dur- ing the surveillance period
Advice for Advisors: Suggestions and Observations from Lawrence to the Present

DTIC Science & Technology

2006-01-01

battalion’s weapons arrived about four days prior to the start of range week. Over 750 brand - new weapons from Bulgaria arrived; due to construction...ING. The commandos graduated from school, returned to Al-Qa’im, and were proudly wearing their berets. They had brand new AK-47s and Glock 19...within all of the 504th ING, only about 10 had pistols. Now we had commandos, often very young soldiers, with pistols, new AK-47s, and brand new red
The Knowledge Engineer as Student: Metacognitive Bases for Asking Good Questions

DTIC Science & Technology

1987-01-01

GROUP Learning. Knowledge Engineering, Knowledge Acquistion , / 05 09 Metaknowledge. - I-erigKnwde Eniae ing nweg cusin 19. ABSTRACT (Continue on...unusual for the CSF protein to be greater than 300? Why is belief concerning bacterial meningitis never greater than 0.4?) "* What accounts for zeroes ...Ad ir lt Research Establisha Portsdown, Portsmouth P06 4A Dipi. Pad . Michael W. Habon Dr. Jerome A. Feldman UNITED KINCDOM Universitat Dusseldorf
Stabilized Laccases as Heterogeneous Bioelectrocatalysts (Postprint)

DTIC Science & Technology

2012-10-01

nature, with examples that range from bacterial species to fungi and plants.19·101 However, certain properties of laccases, such as their protein...identified, includ- ing examples of extremophilic enzymes,l11·121 but the extracellu- lar laccases from wood-rotting fungi , such as Trametes spp...biomolecules not only affects the stability and selectivity of an enzyme towards different substrates but also the charge trans- fer at the electrode
People’s Republic of China Scientific Abstracts, Number 196

DTIC Science & Technology

1978-08-07

Chin-husn [2621 3866 3562], CHAO Fsng-yu [6392 7364 3266], WANG Hsisng-t’ing [3769 4161 1656J, SHIH Hung-ch’ing [2514 3163 3237], WANG Kuo -chih...retention and utilization of pollenless type, and breeding of a new group of sterile lines. AUTHORS: TU Shih -ts’an [2629 0013 3605] CHOU Chia-hua... JUNG Shan [1369 3790] CH’EN Shu-yang [7115 3359 7122] ORG: Both of Northwestern Institute of Botany TITLE: "Some Methods to Cope With Antipathy
A Study of Financial Management Training of Coast Guard Junior Officers in Command Afloat and Ashore.

DTIC Science & Technology

1980-12-01

unlimited. 17. DISTRIBUTION STAT9ENT (*f b. IMNmt at"& R . It dM . o w RuPe) II. SUPPLEUNTARY NOTES 19. KEY WOROS ( gmo oMe -to. s* id mdwoees i u...the operat- ing plan of the particular CG District. This supplement pro - vides the commanding officer with detailed information regard- ing financial...in Figure II-i con - firm that the CG must get the most it can from the few dollars available for use. However, how many CG officers in command
Larger Units: Theater Army -- Army Group -- Field Army

DTIC Science & Technology

1985-01-01

la ing r sky. To prove val ire pport, ire ntrol arties rom h rtillery attalion ceived rai ing serving ntrolling val nfire . rangements ere r ir...servation ntrol f val ire. fantry iv sion val nfire iaison ficer signed. 43 t lization ir sets s y sed e rinciple at ir rength uld ~ ept der...en eaters resented other rce f.ten on . acArthur, r a ple, rrowed al rps) its o , is fusal lease ips edule ened val nfire port e arine
VizieR Online Data Catalog: Catalog of Suspected Nearby Young Stars (Riedel+, 2017)

NASA Astrophysics Data System (ADS)

Riedel, A. R.; Blunt, S. C.; Lambrides, E. L.; Rice, E. L.; Cruz, K. L.; Faherty, J. K.

2018-04-01

LocAting Constituent mEmbers In Nearby Groups (LACEwING) is a frequentist observation space kinematic moving group identification code. Using the spatial and kinematic information available about a target object (α, δ, Dist, μα, μδ, and γ), it determines the probability that the object is a member of each of the known nearby young moving groups (NYMGs). As with other moving group identification codes, LACEwING is capable of estimating memberships for stars with incomplete kinematic and spatial information. (2 data files).
Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses.

PubMed

Parashar, Abhinav; Gideon, Daniel Andrew; Manoj, Kelath Murali

2018-01-01

Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term "murburn" is abstracted from " mur ed burn ing " or " m ild u n r estricted burn ing " and connotes a novel " m olecule- u nbound ion- r adical " interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles. The novel insight necessitates a "reactivity outside the active-site" perspective, because select redox enzymatic activity is obligatorily mediated via diffusible radical/species. Herein, reactions employing key hemeproteins (as exemplified by CYP2E1) establish direct experimental connection between "additive-influenced redox catalysis" and "unusual dose responses" in reductionist and physiological milieu. Thus, direct and conclusive molecular-level experimental evidence is presented, supporting the mechanistic relevance of murburn concept in "maverick" concentration-based effects brought about by additives. Therefore, murburn concept could potentially explain several physiological hormetic and idiosyncratic dose responses.
Temporal and Spatial Shaping of X-Ray Free-Electron Lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, G; Marinelli, AGOSTINO

The x-ray free-electron laser is the brightest source of x-rays, with a peak brightness ten orders of magnitude higher than conventional synchrotron radiation sources. Much like conventional lasers, XFELs are extremely flexible machines and the properties of the x-rays can be controlled by accurately manipulating the lasing medium, i.e. the electron beam. In my talk I will discuss past and present research on shaping the temporal properties of the x-rays at the Linac Coherent Light Source (LCLS). I will discuss the two-color FEL modes and their applications in user experiments. Finally I will present our results on laser-shaping of x-raymore » pulses and our plans for attosecond operation in the soft x-ray regime.« less
OSRD Reports: Bibliography and Index of Declassified Reports Having OSRD Numbers

DTIC Science & Technology

1947-06-01

Jln 191114. • sbp photo., dl.gra. HI $2.00 Ph $8.00. Bibliography OSRO 3312 Pll 12023 (1-831) The Psychological CO~POl𔃽t Ion. Mew York Info...tltl 16 ~ It fire control- n (a) tra inIng couru upon tlle lr vl.ual pra- flc l ncy. (Applied psychology plnll: lee- tlon and tra In Ing of rengeflnder...other. Ex_lnation of en8llV . atar ! el (0D-113: fitrn: "-119): Metallurgical elornlnlltlon of a tall "".,.;1 u,.bly ... d lending gear hydraulle
Cooking Chicken Breast Reduces Dialyzable Iron Resulting from Digestion of Muscle Proteins

PubMed Central

Gokhale, Aditya S.; Mahoney, Raymond R.

2014-01-01

The purpose of this research was to study the effect of cooking chicken breast on the production of dialyzable iron (an in vitro indicator of bioavailable iron) from added ferric iron. Chicken breast muscle was cooked by boiling, baking, sautéing, or deep-frying. Cooked samples were mixed with ferric iron and either extracted with acid or digested with pepsin and pancreatin. Total and ferrous dialyzable iron was measured after extraction or digestion and compared to raw chicken samples. For uncooked samples, dialyzable iron was significantly enhanced after both extraction and digestion. All cooking methods led to markedly reduced levels of dialyzable iron both by extraction and digestion. In most cooked, digested samples dialyzable iron was no greater than the iron-only (no sample) control. Cooked samples showed lower levels of histidine and sulfhydryls but protein digestibility was not reduced, except for the sautéed sample. The results showed that, after cooking, little if any dialyzable iron results from digestion of muscle proteins. Our research indicates that, in cooked chicken, residual acid-extractable components are the most important source of dialyzable iron. PMID:26904627
Cooking Chicken Breast Reduces Dialyzable Iron Resulting from Digestion of Muscle Proteins.

PubMed

Gokhale, Aditya S; Mahoney, Raymond R

2014-01-01

The purpose of this research was to study the effect of cooking chicken breast on the production of dialyzable iron (an in vitro indicator of bioavailable iron) from added ferric iron. Chicken breast muscle was cooked by boiling, baking, sautéing, or deep-frying. Cooked samples were mixed with ferric iron and either extracted with acid or digested with pepsin and pancreatin. Total and ferrous dialyzable iron was measured after extraction or digestion and compared to raw chicken samples. For uncooked samples, dialyzable iron was significantly enhanced after both extraction and digestion. All cooking methods led to markedly reduced levels of dialyzable iron both by extraction and digestion. In most cooked, digested samples dialyzable iron was no greater than the iron-only (no sample) control. Cooked samples showed lower levels of histidine and sulfhydryls but protein digestibility was not reduced, except for the sautéed sample. The results showed that, after cooking, little if any dialyzable iron results from digestion of muscle proteins. Our research indicates that, in cooked chicken, residual acid-extractable components are the most important source of dialyzable iron.
Genomic Instability and Breast Cancer

DTIC Science & Technology

2011-06-01

Survival Assay—Atotal of 1 103 cells were seeded onto a 60-mm dish in triplicate. Twenty-four hours after seeding, cells were irradiated by using a JL...ShepherdMark I-68A 137Cs- irradiator at indicated doses and incubated for 14 days. Result- ing colonies were fixed and stainedwithCoomassie Blue. Num...antibodies, cell culture, transfection and siRNAs, DNA substrates protein purification in insect cells, electrophoretic mobility shift assay and the ATPase
Low ambient temperature during early postnatal development fails to cause a permanent induction of brown adipocytes

PubMed Central

Chabowska-Kita, Agnieszka; Trabczynska, Anna; Korytko, Agnieszka; Kaczmarek, Monika M.; Kozak, Leslie P.

2015-01-01

The brown adipocyte phenotype (BAP) in white adipose tissue (WAT) is transiently induced in adult mammals in response to reduced ambient temperature. Since it is unknown whether a cold challenge can permanently induce brown adipocytes (BAs), we reared C57BL/6J (B6) and AxB8/PgJ (AxB8) mice at 17 or 29°C from birth to weaning, to assess the BAP in young and adult mice. Energy balance measurements showed that 17°C reduced fat mass in the preweaning mice by increasing energy expenditure and suppressed diet-induced obesity in adults. Microarray analysis of global gene expression of inguinal fat (ING) from 10-day-old (D) mice indicates that expression at 17°C vs. 29°C was not different. Between 10 and 21 days of age, the BAP was induced coincident with morphologic remodeling of ING and marked changes in expression of neural development genes (e.g., Akap 12 and Ngfr). Analyses of Ucp1 mRNA and protein showed that 17°C transiently increased the BAP in ING from 21D mice; however, BAs were unexpectedly present in mice reared at 29°C. The involution of the BAP in WAT occurred after weaning in mice reared at 23°C. Therefore, the capacity to stimulate thermogenically competent BAs in WAT is set by a temperature-independent, genetically controlled program between birth and weaning.—Chabowska-Kita, A., Trabczynska, A., Korytko, A., Kaczmarek, M. M., Kozak, L. P. Low ambient temperature during early postnatal development fails to cause a permanent induction of brown adipocytes. PMID:25896784

hEcd, A Novel Regulator of Mammary Epithelial Cell Survival

DTIC Science & Technology

2009-09-01

theYeast Two hybrid analysis with human papilloma virus oncogene E6 (the most efficient oncogene to immortalize hMECs in vitro) as a bait and mammary...transformation. We have identified a novel protein us ing the Yeast Two hybrid analysis with human papilloma virus oncogene E6 (the most efficient...epithelial cell cDNA library, we identified hEcd ( human orthologue of Drosophila Ecdysoneless) as a novel E6 binding partner. To study the cellular
The Role of Vitamin D Stimulation of Mullerian Inhibiting Substance (MIS) in Prostate Cancer Therapy

DTIC Science & Technology

2007-12-01

and cross - linked by addition of 1% formaldehyde. The chromatin was sheared by sonication to obtain DNA fragments of an average of 200-1000 bp in size...with elution buffer. The cross -links were reversed by incubation at 65°C overnight in elution buffer con ta in ing 200 mM NaCl . The...mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer Res 66:4516- 4524 43. Dresser DW, Hacker A
Pituitary and Peripheral Hormone Responses to T3 Administration During Antarctic Residence

DTIC Science & Technology

1988-06-01

CA, and McMurdo, Antarctica. The basal diet consisted of 2,000-2,500 kcalories (kcal), with -40% as carbohydrate, 35% as protein, and 12.5, 12.5, 12.5...and Diet ranges may have precluded us from detecting basal non- Even though the amount of consumed calories in- stimulated differences. Others have... hypocaloric feed- exposure. MOG, microgram. * P < 0.05 compared with warm control ing cannot account for our findings because serum T 3 in climate values
Secreted HSP Vaccine for Malaria Prophylaxis

DTIC Science & Technology

2016-10-26

AWARD NUMBER: W81XWH-13-2-0098 TITLE: Secreted HSP Vaccine for Malaria Prophylaxis PRINCIPAL INVESTIGATOR: Dr. Natasa Strbo CONTRACTING ORGANIZATION...Secreted HSP Vaccine for Malaria Prophylaxis 4. TITLE AND SUBTITLE NATASA STRBO, M.D., D.SC NAME(S) AND E-M tzA UNIVERS]TY OF MTAMI 1600 NW 1OTH AVENUE ROOM...Here we developed malaria vaccine that relies on secreted gp96-lg chaperon-ing Plasmodium falciparum antigenic sporozoite proteins CSP and AMA1. The
Pineal-Induced Depression of Free Thyroxine in Syrian Hamsters

DTIC Science & Technology

1985-01-01

activation by blind- ness in Syrian hamsters, can influence free 14 concentration. MATERIALS AND METHODS Male golden hamsters, Mesocricetus auratus...considered that the changes in T4 passively result from pineal- induced hypogonadism and the possible resultant effects on T4 serum bind- ing proteins...the presence of pineal-induced hypogonadism and that, like T4 and FT41, -• ’. 328 Vaughan and Pruitt TESrE S PROSTATE 0.6 80- 20 gn Mgm ,... =_ 9 Mg_
OD-ing on Reality: An Interview with Alex Flinn

ERIC Educational Resources Information Center

Lesesne, Teri S.

2005-01-01

Alex Flinn discusses her debut novel, Breathing Underwater, which received much critical acclaim. She absolutely felt like her second book was being compared to Breathing Underwater at first. Breaking Point (which was completed before Breathing Underwater was published) was very different in tone. It was darker. The voice was different. The ending…
Medicine Wheel Imag(in)ings: Exploring Holistic Curriculum Perspectives

ERIC Educational Resources Information Center

Kind, Sylvia; Irwin, Rita L.; Grauer, Kit; de Cosson, Alex

2005-01-01

Education is longing for a deeper more connected, more inclusive, and more aware way of knowing. One that connects heart and hand and head and does not split knowledge into dualities of thought and being, mind and body, emotion and intellect, but resonates with a wholeness and fullness that engages every part of one's being. Engagement with the…
FISH-ing for Genes: Modeling Fluorescence "in situ" Hybridization

ERIC Educational Resources Information Center

Baker, William P.; Jones, Carleton Buck

2006-01-01

Teaching methods of genetic analysis such as fluorescence in situ hybridization (FISH) can be an important part of instructional units in biology, microbiology, and biotechnology. Experience, however, indicates that these topics are difficult for many students. The authors of this article describe how they created an activity that effectively…
47 CFR 1.1206 - Permit-but-disclose proceed-ings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technically possible. Where the document to be filed electronically contains metadata that is confidential or... filer may remove such metadata from the document before filing it electronically. (iii) Filing dates...
47 CFR 1.1206 - Permit-but-disclose proceed-ings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technically possible. Where the document to be filed electronically contains metadata that is confidential or... filer may remove such metadata from the document before filing it electronically. (iii) Filing dates...
Weight-ing: the experience of waiting on weight loss.

PubMed

Glenn, Nicole M

2013-03-01

Perhaps we want to be perfect, strive for health, beauty, and the admiring gaze of others. Maybe we desire the body of our youth, the "healthy" body, the body that has just the right fit. Regardless of the motivation, we might find ourselves striving, wanting, and waiting on weight loss. What is it to wait on weight loss? I explore the meaning of this experience-as-lived using van Manen's guide to phenomenological reflection and writing. Weight has become an increasing focus of contemporary culture, demonstrated, for example, by a growing weight-loss industry and global obesity "epidemic." Weight has become synonymous with health status, and weight loss with "healthier." I examine the weight wait through experiences of the common and uncommon, considering relations to time, body, space, and the other with the aim of evoking a felt, embodied, emotive understanding of the meaning of waiting on weight loss. I also discuss the implications of the findings.
Taking (or Is that "Tech"ing) Back the Future

ERIC Educational Resources Information Center

Foster, Forrest C.

2011-01-01

Technology has ushered itself into our culture without borders or boundaries. Students and educators have fallen victim to the notion of "information at your fingertips" and "easy access" while taking many things for granted. In the past few years, there have been several articles written about the use of textbooks in the academic library. Most of…
Persistence(ing): Posthuman Agency in a Writers' Studio

ERIC Educational Resources Information Center

Kuby, Candace R; Rucker, Tara Gutshall; Darolia, Laura H.

2017-01-01

This manuscript focuses on agency from a posthumanist stance. For so long, educators' definitions of agency have focused solely on people. As we read more on posthuman ideas of agency, we were also reading Deleuze and Guattari's work on philosophy and concepts. These two bodies of scholarship intra-acted with each other to create newness of ideas…
MicroRNA-193 Pro-Proliferation Effects for Bone Mesenchymal Stem Cells After Low-Level Laser Irradiation Treatment Through Inhibitor of Growth Family, Member 5

PubMed Central

Wang, Jue; Huang, Weicong; Wu, Yihe; Hou, Jianfeng; Nie, Yu; Gu, Haiyong; Li, Jun; Hu, Shengshou

2012-01-01

The enhanced proliferation of mesenchymal stem cells (MSCs) can be helpful for the clinical translation of cell therapy. Low-level laser irradiation (LLLI) has been demonstrated as regulating MSC proliferation. MicroRNAs (miRNAs) are involved in various pathophysiologic processes in stem cells, but the role of miRNAs in the LLLI-based promotion of MSC proliferation remains unclear. We found that the proliferation level and cell cycle-associated genes in MSCs were increased after LLLI treatment in a time-dependent manner. Microarray assays revealed subsets of miRNAs to be differentially regulated, and these dynamic changes were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) after LLLI. miR-193 was the most highly up-regulated miRNA, and the change in it was related with the proliferation level. Gain-loss function experiments demonstrated that miR-193 could regulate the proliferation of MSCs, including human's and rat's, but could not affect the apoptosis and differentiation level. Blockade of miR-193 repressed the MSC proliferation induced by LLLI. By qRT-PCR, we found that miR-193, in particular, regulated cyclin-dependent kinase 2 (CDK2) expression. Bioinformatic analyses and luciferase reporter assays revealed that inhibitor of growth family, member 5 (ING5) could be the best target of miR-193 to functionally regulate proliferation and CDK2 activity, and the mRNA and protein level of ING5 was regulated by miR-193. Furthermore, the ING5 inhibited by small interfering RNA (siRNA) could up-regulate the proliferation of MSCs and the expression of CDK2. Taken together, these results strongly suggest that miR-193 plays a critical part in MSC proliferation in response to LLLI stimulation, which is potentially amenable to therapeutic manipulation for clinical application. PMID:22384930
7 Å Resolution in Protein 2-Dimentional-Crystal X-Ray Diffraction at Linac Coherent Light Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pedrini, Bill; Tsai, Ching-Ju; Capitani, Guido

2014-06-09

Membrane proteins arranged as two-dimensional (2D) crystals in the lipid en- vironment provide close-to-physiological structural information, which is essential for understanding the molecular mechanisms of protein function. X-ray diffraction from individual 2D crystals did not represent a suitable investigation tool because of radiation damage. The recent availability of ultrashort pulses from X-ray Free Electron Lasers (X-FELs) has now provided a mean to outrun the damage. Here we report on measurements performed at the LCLS X-FEL on bacteriorhodopsin 2D crystals mounted on a solid support and kept at room temperature. By merg- ing data from about a dozen of single crystalmore » diffraction images, we unambiguously identified the diffraction peaks to a resolution of 7 °A, thus improving the observable resolution with respect to that achievable from a single pattern alone. This indicates that a larger dataset will allow for reliable quantification of peak intensities, and in turn a corresponding increase of resolution. The presented results pave the way to further X-FEL studies on 2D crystals, which may include pump-probe experiments at subpicosecond time resolution.« less
Relationship between the mechanisms of gamma rhythm generation and the magnitude of the macroscopic phase response function in a population of excitatory and inhibitory modified quadratic integrate-and-fire neurons

NASA Astrophysics Data System (ADS)

Akao, Akihiko; Ogawa, Yutaro; Jimbo, Yasuhiko; Ermentrout, G. Bard; Kotani, Kiyoshi

2018-01-01

Gamma oscillations are thought to play an important role in brain function. Interneuron gamma (ING) and pyramidal interneuron gamma (PING) mechanisms have been proposed as generation mechanisms for these oscillations. However, the relation between the generation mechanisms and the dynamical properties of the gamma oscillation are still unclear. Among the dynamical properties of the gamma oscillation, the phase response function (PRF) is important because it encodes the response of the oscillation to inputs. Recently, the PRF for an inhibitory population of modified theta neurons that generate an ING rhythm was computed by the adjoint method applied to the associated Fokker-Planck equation (FPE) for the model. The modified theta model incorporates conductance-based synapses as well as the voltage and current dynamics. Here, we extended this previous work by creating an excitatory-inhibitory (E-I) network using the modified theta model and described the population dynamics with the corresponding FPE. We conducted a bifurcation analysis of the FPE to find parameter regions which generate gamma oscillations. In order to label the oscillatory parameter regions by their generation mechanisms, we defined ING- and PING-type gamma oscillation in a mathematically plausible way based on the driver of the inhibitory population. We labeled the oscillatory parameter regions by these generation mechanisms and derived PRFs via the adjoint method on the FPE in order to investigate the differences in the responses of each type of oscillation to inputs. PRFs for PING and ING mechanisms are derived and compared. We found the amplitude of the PRF for the excitatory population is larger in the PING case than in the ING case. Finally, the E-I population of the modified theta neuron enabled us to analyze the PRFs of PING-type gamma oscillation and the entrainment ability of E and I populations. We found a parameter region in which PRFs of E and I are both purely positive in the case of
Changes in Hormonal Concentrations after Different Heavy-Resistance Exercise Protocols in Women

DTIC Science & Technology

1993-01-01

men, we values were 62.1 ± 5.6% (SD) carbohydrate , 13.5 ± 2.3% have previously demonstrated that these two acute pro- protein, and 24.4 ± 6.3% fat...growth hormone. These find- hormone has a complex influence on carbohydrate me- ings may be due to the much higher resting baseline of tabolism, with its...A. WESEMAN. B. P. CONROY, S. E. acteristics of national -caliber United States women weightlifters . GORDON. J. R. HOFFMAN, AND C. M. MARESH. The
Walter Hohmann's contributions towards space flight: an appreciation on the occasion of the centenary of his birthday

NASA Astrophysics Data System (ADS)

Schulz, Werner

1980-11-01

In 1923 Hermann Oberth published his book "Die Rakete zu den Planetenräumen" (The Rocket into Planetary Space), in 1924 Max Valier's book "Der Vorstoss in den Weltenraum" (The Advance into Space) appeared while in the U.S.A. already in 1919 Robert H. Goddard reported on his rocket experiments. Altogether different from the publications just mentioned was a book entitled "Die Erreichbarkeit der Himmelskörper" (The Attainability of Celestial Bodies) published in 1925. Its author was Dr.-Ing. Walter Hohmann, born 18 March 1880, civil engineer for the city authorities of Essen, who had already made, during World War I, calculations as to the amount of fuel, initial mass and flight time necessary for flights from the Earth to other planets. The transfer trajectories investigated by Hohmann and today attributed with his name have a great practical significance for space flight onto the present. In the lecture a critical appreciation of Hohmann's work is given.
Membrane-bound heat shock proteins facilitate the uptake of dying cells and cross-presentation of cellular antigen.

PubMed

Zhu, Haiyan; Fang, Xiaoyun; Zhang, Dongmei; Wu, Weicheng; Shao, Miaomiao; Wang, Lan; Gu, Jianxin

2016-01-01

Heat shock proteins (HSPs) were originally identified as stress-responsive proteins and serve as molecular chaperones in different intracellular compartments. Translocation of HSPs to the cell surface and release of HSPs into the extracellular space have been observed during the apoptotic process and in response to a variety of cellular stress. Here, we report that UV irradiation and cisplatin treatment rapidly induce the expression of membrane-bound Hsp60, Hsp70, and Hsp90 upstream the phosphatidylserine exposure. Membrane-bound Hsp60, Hsp70 and Hsp90 could promote the release of IL-6 and IL-1β as well as DC maturation by the evaluation of CD80 and CD86 expression. On the other hand, Hsp60, Hsp70 and Hsp90 on cells could facilitate the uptake of dying cells by bone marrow-derived dendritic cells. Lectin-like oxidized LDL receptor-1 (LOX-1), as a common receptor for Hsp60, Hsp70, and Hsp90, is response for their recognition and mediates the uptake of dying cells. Furthermore, membrane-bound Hsp60, Hsp70 and Hsp90 could promote the cross-presentation of OVA antigen from E.G7 cells and inhibition of the uptake of dying cells by LOX-1 decreases the cross-presentation of cellular antigen. Therefore, the rapid exposure of HSPs on dying cells at the early stage allows for the recognition by and confers an activation signal to the immune system.
Energetics and Structure Prediction of the Network of Homo- and Hetero-Oligomers Formed by the Transmembrane Domains of the ErbB Receptor Family of Proteins

DTIC Science & Technology

2005-06-01

acid residue motif, Small-x-x-Large-G/A, consist- complexes is critical to understanding the signal ing of a small residue (Gly, Ala , Ser, Thr, or Pro...in transduction process. Recent structures of the the zero position, a large aliphatic residue ( Ala , Val, ligand-binding domains of the erbB...receptors Leu, or Ile) in position 3, followed by Gly or Ala in have begun to provide insight into the mechanisms position four.’ This motif was identified

The Role of I-kappa-B Kinases in Prostate Carcinogenesis and the Effect of Their Inhibition on Survival of Prostate Tumors

DTIC Science & Technology

2007-01-01

incorporation, which identifies cells undergoing DNA synthesis , was examined 2.5 hrs later. Fewer BrdU-positive cells were present in CaP of IkkαAA/AA/TRAMP...RNA synthesis are inhibited or in NF-κB-deficient cells. NF-κB exerts its pro-survival activity by induc- ing expression of several anti-apoptotic...new protein or RNA synthesis is inhibited or in NF-κB–deficient cells. NF-κB exerts its pro-survival activity through several anti- apoptotic proteins
Development of biological tools to assess the role of TMPRSS4 and identification of novel tumor types with high expression of this prometastatic protein.

PubMed

Villalba, Maria; Lopez, Lissett; Redrado, Miriam; Ruiz, Tamara; de Aberasturi, Arrate L; de la Roja, Nuria; Garcia, David; Exposito, Francisco; de Andrea, Carlos; Alvarez-Fernandez, Emilio; Montuenga, Luis; Rueda, Paloma; Rodriguez, Maria Jose; Calvo, Alfonso

2017-09-01

Metastatic spread is responsible for the majority of cancer deaths and identification of metastasis-related therapeutic targets is compulsory. TMPRSS4 is a pro-metastatic druggable transmembrane type II serine protease whose expression has been associated with the development of several cancer types and poor prognosis. To study the role and expression of this protease in cancer, we have developed molecular tools (active recombinant proteins and a polyclonal antibody) that can be used for diagnostic purposes and for testing anti-TMPRSS4 drugs. In addition, we have evaluated TMPRSS4 protein expression in several cancer tissue microarrays (TMAs). Full length and truncated TMPRSS4 recombinant proteins maintained the catalytic activity in two different expression systems (baculovirus and E. coli). Sensitivity of the rabbit polyclonal antisera against TMPRSS4 (ING-pAb) outperformed the antibody most commonly used in clinical settings. Analysis by immunohistochemistry in the different TMAs identified a subset of adenocarcinomas, squamous carcinomas, large cell carcinomas and carcinoids of the lung, which may define aggressive tumors. In conclusion, our biological tools will help the characterization of TMPRSS4 activity and protein expression, as well as the evaluation of anti-TMRSS4 drugs. Future studies should determine the clinical value of assessing TMPRSS4 levels in different types of lung cancer.
Surging glaciers in Iceland - research status and future challenges

NASA Astrophysics Data System (ADS)

Ingolfsson, Olafur

2013-04-01

Twenty six Icelandic outlet glaciers, ranging from 0.5-1.500 km2, are known to surge, with terminal advances ranging from of few tens of meters to about 10 km. The geomorphic signatures of surges vary, from large-scale folded and thrusted end moraine systems, extensive dead-ice fields and drumlinized forefields to drift sheets where fast ice-flow indicators are largely missing. Case studies from the forefields of Brúarjökull, Eyjabakkajökull and Múlajökull surging glaciers will be presented. At Brúarjökull, extremely rapid ice flow during surge was sustained by overpressurized water causing decoupling beneath a thick sediment sequence that was coupled to the glacier. The ice-marginal position of the 1890 surge is marked by a sedimentary wedge formed within five days and a large moraine ridge that formed in about one day ("instantaneous end-moraine"). Three different qualitative and conceptual models are required to explain the genesis of the Eyjabakkajökull moraines: a narrow, single-crested moraine ridge at the distal end of a marginal sediment wedge formed in response to decoupling of the subglacial sediment from the bedrock and associated downglacier sediment transport; large lobate end moraine ridges with multiple, closely spaced, asymmetric crests formed by proglacial piggy-back thrusting; moraine ridges with different morphologies may reflect different members of an end moraine continuum. A parallel study highlighting the surge history of Eyjabakkajökull over the last 4400 years suggests climate control on surge frequencies. The Múlajökull studies concern an active drumlin field (>100 drumlins) that is being exposed as the glacier retreats. The drumlins form through repeated surges, where each surge causes deposition of till bed onto the drumlin while similtaneously eroding the sides. Finally, a new landsystem model for surging North Iceland cirque glaciers will be introduced. References Benediktsson,I. Ö., Schomacker, A., Lokrantz, H. & Ing
Energetics and Structure Prediction of the Network of Homo- and Hetero-Oligomers Formed by the Transmembrane Domains of the ErbReceptor Family of Proteins

DTIC Science & Technology

2006-06-01

amino acid residue motif, Small-x-x-Large-G/A, consist- ing of a small residue (Gly, Ala , Ser, Thr, or Pro) in the zero position, a large aliphatic...residue ( Ala , Val, Leu, or Ile) in position 3, followed by Gly or Ala in position four.15 This motif was identified in a large number of receptor tyrosine...M. A., Codony-Servat, J., Albanell, J., Rojo, F., Arribas , J. & Baselga, J. (2001). Trastuzumab (her- ceptin), a humanized anti-Her2 receptor
Identification of proteins from 4200-year-old skin and muscle tissue biopsies from ancient Egyptian mummies of the first intermediate period shows evidence of acute inflammation and severe immune response.

PubMed

Jones, Jana; Mirzaei, Mehdi; Ravishankar, Prathiba; Xavier, Dylan; Lim, Do Seon; Shin, Dong Hoon; Bianucci, Raffaella; Haynes, Paul A

2016-10-28

We performed proteomics analysis on four skin and one muscle tissue samples taken from three ancient Egyptian mummies of the first intermediate period, approximately 4200 years old. The mummies were first dated by radiocarbon dating of the accompany-\\break ing textiles, and morphologically examined by scanning electron microscopy of additional skin samples. Proteins were extracted, separated on SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) gels, and in-gel digested with trypsin. The resulting peptides were analysed using nanoflow high-performance liquid chromatography-mass spectrometry. We identified a total of 230 unique proteins from the five samples, which consisted of 132 unique protein identifications. We found a large number of collagens, which was confirmed by our microscopy data, and is in agreement with previous studies showing that collagens are very long-lived. As expected, we also found a large number of keratins. We identified numerous proteins that provide evidence of activation of the innate immunity system in two of the mummies, one of which also contained proteins indicating severe tissue inflammation, possibly indicative of an infection that we can speculate may have been related to the cause of death.This article is part of the themed issue 'Quantitative mass spectrometry'. © 2016 The Author(s).
Identification of proteins from 4200-year-old skin and muscle tissue biopsies from ancient Egyptian mummies of the first intermediate period shows evidence of acute inflammation and severe immune response

PubMed Central

Jones, Jana; Mirzaei, Mehdi; Ravishankar, Prathiba; Xavier, Dylan; Lim, Do Seon; Shin, Dong Hoon; Bianucci, Raffaella

2016-01-01

We performed proteomics analysis on four skin and one muscle tissue samples taken from three ancient Egyptian mummies of the first intermediate period, approximately 4200 years old. The mummies were first dated by radiocarbon dating of the accompany-\\break ing textiles, and morphologically examined by scanning electron microscopy of additional skin samples. Proteins were extracted, separated on SDS–PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) gels, and in-gel digested with trypsin. The resulting peptides were analysed using nanoflow high-performance liquid chromatography–mass spectrometry. We identified a total of 230 unique proteins from the five samples, which consisted of 132 unique protein identifications. We found a large number of collagens, which was confirmed by our microscopy data, and is in agreement with previous studies showing that collagens are very long-lived. As expected, we also found a large number of keratins. We identified numerous proteins that provide evidence of activation of the innate immunity system in two of the mummies, one of which also contained proteins indicating severe tissue inflammation, possibly indicative of an infection that we can speculate may have been related to the cause of death. This article is part of the themed issue ‘Quantitative mass spectrometry’. PMID:27644972
De/signing Research in Education: Patchwork(ing) Methodologies with Theory

ERIC Educational Resources Information Center

Higgins, Marc; Madden, Brooke; Berard, Marie-France; Lenz Kothe, Elsa; Nordstrom, Susan

2017-01-01

Four education scholars extend the methodological space inspired by Jackson and Mazzei's "Thinking with Theory" through focusing on research design. The notion of de/sign is presented and employed to counter prescriptive method/ology that often sutures over pedagogical possibilities in research and educational settings. Key…
Tales from Camp Wilde: Queer(y)ing Environmental Education Research

ERIC Educational Resources Information Center

Gough, Noel; Gough, Annette

2003-01-01

This paper questions the relative silence of queer theory and theorizing in environmental education research. We explore some possibilities for queering environmental education research by fabricating (and inviting colleagues to fabricate) stories of Camp Wilde, a fictional location that helps us to expose the facticity of the field's…
Imag(in)ing the University: Visual Sociology and Higher Education

ERIC Educational Resources Information Center

Metcalfe, Amy Scott

2012-01-01

This study examines the potential of visual sociology to expand our knowledge of higher education through the use of visual data sources and methods of analysis. Photographs and archival material form the basis of the study. The images were analyzed as being part of the initiation and fulfillment stages of the social construction of collective…
[Presentation of age(ing) and elderly people in TV commercials].

PubMed

Hoppe, Theresa; Tischer, Ulrike; Philippsen, Christine; Hartmann-Tews, Ilse

2016-06-01

From the results of different studies it is known that stereotyped images about ageing and elderly people frame and influence the attitudes, beliefs and activities of elderly people and also influence the interaction of others with elderly people. The purpose of this study was to assess the currently portrayed images of elderly people, age and ageing in television (TV) advertisements. The study was based on a qualitative and quantitative content analysis of commercials presented on four major TV networks, two private and two public TV broadcasting networks in Germany. The sample covered 114 different commercials which included 131 elderly actors (approximately 50 + years). The results show that the products most often portrayed in commercials with elderly people are related to food, followed by prescription drugs and health, insurance and hygiene products. Elderly people are still underrepresented in TV commercials. Their characters are portrayed with overwhelmingly positive attributes and traits. The findings suggest that TV advertisements create an ideal image of active and healthy ageing. Further research might explore to what extent elderly people take this ideal image of ageing as their own interpretive frame of orientation.
The a“MAZE”ing World of Lung-Specific Transgenic Mice

PubMed Central

Rawlins, Emma L.

2012-01-01

The purpose of this review is to give a comprehensive overview of transgenic mouse lines suitable for studying gene function and cellular lineage relationships in lung development, homeostasis, injury, and repair. Many of the mouse strains reviewed in this Perspective have been widely shared within the lung research community, and new strains are continuously being developed. There are many transgenic lines that target subsets of lung cells, but it remains a challenge for investigators to select the correct transgenic modules for their experiment. This review covers the tetracycline- and tamoxifen-inducible systems and focuses on conditional lines that target the epithelial cells. We point out the limitations of each strain so investigators can choose the system that will work best for their scientific question. Current mesenchymal and endothelial lines are limited by the fact that they are not lung specific. These lines are summarized in a brief overview. In addition, useful transgenic reporter mice for studying lineage relationships, promoter activity, and signaling pathways will complete our lung-specific conditional transgenic mouse shopping list. PMID:22180870
A Jester's Guide to Creative See[k]ing across Disciplines

ERIC Educational Resources Information Center

Rosen, Diane

2012-01-01

For many centuries and in many cultures, jesters recited tales of heroic exploits, but they did more than simply recount past events--they amused, cajoled, and spun tales that transported listeners to the edge of mysterious, unmapped territories. Through the transformative power of play and the imagination, they reworked what was already…
Fire in operating theatres: DaSH-ing to the rescue.

PubMed

Wilson, Liam; Farooq, Omer

2018-01-01

Operating theatres are dynamic environments that require multi professional team interactions. Effective team working is essential for efficient delivery of safe patient care. A fire in the operating theatre is a rare but potentially life threatening event for both patients and staff. A rapid and cohesive response from theatre and allied staff including porters, fire safety officer etc is paramount. We delivered a training session that utilised in situ simulation (simulation in workplace). After conducting needs analysis, learning objectives were agreed. After thorough planning, the date and location of the training session were identified. Contingency plans were put in place to ensure that patient care was not compromised at any point. To ensure success, checklists for faculty were devised and adhered to. A medium fidelity manikin with live monitoring was used. The first part of the scenario involved management of a surgical emergency by theatre staff. The second part involved management of a fire in the operating theatre while an emergency procedure was being undertaken. To achieve maximum learning potential, debriefing was provided immediately after each part of the scenario. A fire safety officer was present as a content expert. Latent errors (hidden errors in the workplace, staff knowledge etc) were identified. Malfunctioning of theatre floor windows and staff unawareness about the location of an evacuation site were some of the identified latent errors. Thorough feedback to address these issues was provided to the participants on the day. A detailed report of the training session was given to the relevant departments. This resulted in the equipment faults being rectified. The training session was a very positive experience and helped not only in improving participants' knowledge, behaviour and confidence but also it made system and environment better equipped.
STEM-ING the Skills Gap. Washington's Community and Technical Colleges

ERIC Educational Resources Information Center

Washington State Board for Community and Technical Colleges, 2013

2013-01-01

Washington could add as many as 110,000 new jobs by 2017 by closing skill gaps--the mismatch between the skills people have and those employers need, according to a March 2013 Washington Roundtable report. STEM professions face the most critical demand. Of the 25,000 jobs vacant for three months or more due to a shortage of qualified candidates,…
Vitamin C: C-ing a New Way to Fight Leukemia.

PubMed

Schönberger, Katharina; Cabezas-Wallscheid, Nina

2017-11-02

Metabolic cues and (epi-)genetic factors are emerging regulators of hematopoietic stem cell (HSC) potency. Two new studies in Nature and Cell, from Agathocleous et al. (2017) and Cimmino et al. (2017), respectively, show that vitamin C regulates HSC function and suppresses leukemogenesis by modulating Tet2 activity. Copyright © 2017 Elsevier Inc. All rights reserved.
40 CFR 403.10 - Development and submission of NPDES State pretreatment programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND... Industrial User is in compliance with Pretreatment Standards; (iv) Seek civil and criminal penalties, and...
DOE Office of Scientific and Technical Information (OSTI.GOV)

Rees, Brian G.

Training for Emergency responders - including international partners. This presentation has the following slides answering questions as to Why, How, What and How, Comparison, Issues, ID’ing, Spectra, and Medical Irradiator.
Different types of Internet use, depression, and social anxiety: the role of perceived friendship quality.

PubMed

Selfhout, Maarten H W; Branje, Susan J T; Delsing, M; ter Bogt, Tom F M; Meeus, Wim H J

2009-08-01

The current study examined the longitudinal associations of time spent on Internet activities for communication purposes (i.e., IM-ing) versus time spent on Internet activities for non-communication purposes (i.e., surfing) with depression and social anxiety, as well as the moderating role of perceived friendship quality in these associations. Questionnaire data were gathered from 307 Dutch middle adolescents (average age 15 years) on two waves with a one-year interval. For adolescents who perceive low friendship quality, Internet use for communication purposes predicted less depression, whereas Internet use for non-communication purposes predicted more depression and more social anxiety. These results support social compensation effects of IM-ing on depression and poor-get-poorer effects of surfing on depression and social anxiety, respectively.
Analysis of Deep Attack Operations Operation Bagration Belorussia 22 June-29 August 1944

DTIC Science & Technology

1987-03-01

v e r s which almost all r a n n o r t h o r south, t h e Dnieper, Drut, Beres ina , Western Dvina, Svis loch, P t i ch , and Neman . A l l...2d BRB t o the - Neman , and 1st BRF t o the western Bug, on t h e borders o f Poland, f i n a l l y br inging his l e f t wing i n t o ac...bridgeheads over the Vis tu l a River, as wel l a s t h e f u l l cross ing of t h e Neman and Narev Rivera on t h e way t o East Pmss ia
8th Argentinean Bioengineering Society Conference (SABI 2011) and 7th Clinical Engineering Meeting

NASA Astrophysics Data System (ADS)

Meschino, Gustavo Javier; Ballarin, Virginia L.

2011-12-01

President Dr Gustavo Meschino Universidad Nacional de Mar del Plata Comittee Dr Gustavo Abraham Universidad Nacional de Mar del Plata - CONICET Mg Rubén Acevedo Universidad Nacional de Entre Ríos Ing Pablo Agüero Universidad Nacional de Mar del Plata Ing Mariela Ambrustolo Universidad Nacional de Mar del Plata Dr Ricardo Armentano Universidad Favaloro Dra Virginia L Ballarin Universidad Nacional de Mar del Plata Dra Josefina Ballarre Universidad Nacional de Mar del Plata - CONICET Dr Eduardo Blotta Universidad Nacional de Mar del Plata Ing Marco Benalcázar Universidad Nacional de Mar del Plata Mg Freddy Geovanny Benalcázar Palacios Escuela Superior Politécnica de Chimborazo, Ecuador Dr Roberto Boeri Universidad Nacional de Mar del Plata - CONICET - INTEMA Dra Agustina Bouchet Universidad Nacional de Mar del Plata Dr Ariel Braidot Universidad Nacional de Entre Ríos Dr Marcel Brun Universidad Nacional de Mar del Plata Dra Silvia Ceré Universidad Nacional de Mar del Plata - CONICET Ing Fernando Clara Universidad Nacional de Mar del Plata Dr Raúl Correa Prado Universidad Nacional de San Juan Bioing Pablo Cortez Universidad Nacional de Mar del Plata Dra Teresita R Cuadrado Universidad Nacional de Mar del Plata - CONICET Ing Eduardo De Forteza Universidad Favaloro Dra Mariana Del Fresno Universidad Nacional del Centro de la Provincia de Buenos Aires Dr Martín Diaz Informática Médica Hospital Aleman de Buenos Aires - GIBBA Ing Julio César Doumecq Universidad Nacional de Mar del Plata Mg Ana María Echenique Universidad Nacional de San Juan Bioing Pedro Escobar Universidad Nacional del Centro, Olavarría, Pcia de Buenos Aires Dr Fernando Daniel Farfán Universidad Nacional de Tucumán Dr Carmelo Felice Universidad Nacional de Tucumán - CONICET Dr Elmer Fernández Universidad Católica de Córdoba - CONICET Ing José Flores Universidad Nacional de Entre Ríos Dr Arturo Gayoso Universidad Nacional de Mar del Plata Dra Bioing Agustina Garcés Universidad Nacional de San

Geothermal Exploration in Hot Springs, Montana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toby McIntosh, Jackola Engineering

2012-09-26

The project involves drilling deeper in the Camp Aqua well dri lled in June 1982 as part of an effort to develop an ethanol plant. The purpose of the current drill ing effort is to determine if water at or above 165°F exists for the use in low temperature resource power generation. Previous geothermal resource study efforts in and around Hot Springs , MT and the Camp Aqua area (NE of Hot Springs) have been conducted through the years. A confined gravel aquifer exists in deep alluvium overlain by approximately 250 of si lt and c lay deposits from Glacialmore » Lake Missoula. This gravel aquifer overlies a deeper bedrock aquifer. In the Camp Aqua area several wel l s exist in the gravel aquifer which receives hot water f rom bedrock fractures beneath the area. Prior to this exploration, one known well in the Camp Aqua area penetrated into the bedrock without success in intersecting fractures transporting hot geothermal water. The exploration associated with this project adds to the physical knowledge database of the Camp Aqua area. The dri l l ing effort provides additional subsurface information that can be used to gain a better understanding of the bedrock formation that i s leaking hot geothermal water into an otherwise cold water aquifer. The exi s t ing well used for the explorat ion is located within the center of the hottest water within the gravel aquifer. This lent i t sel f as a logical and economical location to continue the exploration within the existing well. Faced with budget constraints due to unanticipated costs, changing dril l ing techniques stretched the limited project resources to maximize the overa l l well depth which f e l l short of original project goals. The project goal of finding 165°F or hotter water was not achieved; however the project provides additional information and understanding of the Camp Aqua area that could prove valuable in future exploration efforts« less
Preventing Heat-Related Illness or Death of Outdoor Workers

MedlinePlus

... attention to workers who show signs of heat-related illness Evaluating work practices continually to reduce ex- ertion and environmental heat stress Monitoring weather reports daily and reschedul- ing jobs ...
Temporal Tuning Effects in the Visually Evoked Response,

DTIC Science & Technology

1985-08-01

1 B . Characteristics off the EEG................................... 3 C. Characteristics off the VER...18’ B . Record~ing Apparatus .......... ... .. .... .............. .18 IV. PROCEDURE ..................... .. ........ ......... .. .... 19 V...RESULJTS ............. . .... ... .. . ... ................ t....... 21 A. Combined Presentation vs Single Presentations ............. 21 B
Automating Network Node Behavior Characterization by Mining Communication Patterns

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carroll, Thomas E.; Chikkagoudar, Satish; Arthur-Durett, Kristine M.

Enterprise networks of scale are complex, dynamic computing environments that respond to evolv- ing business objectives and requirements. Characteriz- ing system behaviors in these environments is essential for network management and cyber security operations. Characterization of system’s communication is typical and is supported using network flow information (NetFlow). Related work has characterized behavior using theoretical graph metrics; results are often difficult to interpret by enterprise staff. We propose a different approach, where flow information is mapped to sets of tags that contextualize the data in terms of network principals and enterprise concepts. Frequent patterns are then extracted and are expressedmore » as behaviors. Behaviors can be com- pared, identifying systems expressing similar behaviors. We evaluate the approach using flow information collected by a third party.« less
Prediction of perceptual defense from experimental stress and susceptibility to stress as indicated by thematic apperception.

PubMed

Tuma, J M

1975-02-01

The present investigation tested the hypothesis advanced by J. Inglis (1961) that perceptual defense and perceptual vigilance result from an interaction between personality differences and degrees of experimental stress. The design, which controlled for questionable procedures used in previous studies, utilized 32 introverts and 32 extraverts, half male and half female, in an experiment with a visual recognition-task. Results indicated that under low-stress conditions introverts and extraverts identified by their response to a thematic apperception task react to threatening stimuli with perceptual defense and perceptual vigilance, respectively. Under high-stress conditions, type of avoidance activity reverses; extraverts react with perceptual defense and introverts with perceptual vigilance. It was suggested that, when both personality and stress variables are controlled, results of the perceptual defense paradigm are predictable and consistent, in support of Inglis' hypothesis.
BATTLE (Biomarker-based Approaches of Targeted Therapy for Lung Cancer Elimination)

DTIC Science & Technology

2011-04-01

bleach- ing. IF microscopy was performed using a Zeiss Axioplan fluorescence microscope ( Carl Zeiss Inc.) equipped with a 100-W Hg lamp and narrow...laser scanning microscope ( Carl Zeiss Inc.) equipped with an argon laser (458/477/488/514 nm, 30 mW), HeNe laser (413 nm, 1 mW and 633 nm, 5 mW), LSM...Protein-3 (IGFBP-3) in Epithelial IGF-Induced Lung Cancer Development Woo-Young Kim, Mi- Jung Kim,* Hojin Moon,* Ping Yuan, Jin-Soo Kim, Jong-Kyu Woo
Getting the Facts on Food Allergy Testing

MedlinePlus

... ing, vomiting or trouble breathing after eating or coming into contact with a certain food, you may ... swelling, vomiting or trouble breathing after eating or coming into contact with certain foods, it’s important to ...
Cloud Properties from Satellite Infrared and Visible Measurements

DTIC Science & Technology

1976-12-07

Rudiometer Veta. NOM Teen - nical Memorandum WESS 52. Deiruendjian, D., 1969: Electromagnetic Scatter- ing on Spherical Polydispersions. American...asu m ents, Cloud mass liquid water content, Cloud altitudes, Hydrometeor * erosion DOI PORN 1473 NOV *11’.
1977 Nationwide Personal Transportation Study : household vehicle ownership

DOT National Transportation Integrated Search

1980-12-01

This report is part of a series that presents fi??ings from the 1977 Nationwide Personal Transportation Study (NPTS). The report contains data on household vehicles and characteristics of households owning vehicles. Vehicle ownership is explored rela...
Improving an Empirical Formula for the Absorption of Sound in the Sea

DTIC Science & Technology

2008-05-01

Onderwater propagatie Advanced acoustic modelling Auteur (s) ir. C.A.M van Moll Programmanummer Projectnummer dr. M.A. Ainslie V512 032.11648 ing. J...versus calculated absorption .................................................................... 9 3 Inverse theory ...45 7.1 Statistical theory
The Lead-Safe Certified Guide to Renovate Right

MedlinePlus

... for information about courses and resources on lead-safe work practices. 1 RENOVAT ING, REPA IRING, OR PA ... child care facility or school. • Always use lead-safe work practices when renovation or repair will disturb painted ...
Middle to Late Devonian-Carboniferous collapse basins on the Finnmark Platform and in the southwesternmost Nordkapp basin, SW Barents Sea

NASA Astrophysics Data System (ADS)

Koehl, Jean-Baptiste P.; Bergh, Steffen G.; Henningsen, Tormod; Faleide, Jan Inge

2018-03-01

The SW Barents Sea margin experienced a pulse of extensional deformation in the Middle-Late Devonian through the Carboniferous, after the Caledonian Orogeny terminated. These events marked the initial stages of formation of major offshore basins such as the Hammerfest and Nordkapp basins. We mapped and analyzed three major fault complexes, (i) the Måsøy Fault Complex, (ii) the Rolvsøya fault, and (iii) the Troms-Finnmark Fault Complex. We discuss the formation of the Måsøy Fault Complex as a possible extensional splay of an overall NE-SW-trending, NW-dipping, basement-seated Caledonian shear zone, the Sørøya-Ingøya shear zone, which was partly inverted during the collapse of the Caledonides and accommodated top-NW normal displacement in Middle to Late Devonian-Carboniferous times. The Troms-Finnmark Fault Complex displays a zigzag-shaped pattern of NNE-SSW- and ENE-WSW-trending extensional faults before it terminates to the north as a WNW-ESE-trending, NE-dipping normal fault that separates the southwesternmost Nordkapp basin in the northeast from the western Finnmark Platform and the Gjesvær Low in the southwest. The WNW-ESE-trending, margin-oblique segment of the Troms-Finnmark Fault Complex is considered to represent the offshore prolongation of a major Neoproterozoic fault complex, the Trollfjorden-Komagelva Fault Zone, which is made of WNW-ESE-trending, subvertical faults that crop out on the island of Magerøya in NW Finnmark. Our results suggest that the Trollfjorden-Komagelva Fault Zone dies out to the northwest before reaching the western Finnmark Platform. We propose an alternative model for the origin of the WNW-ESE-trending segment of the Troms-Finnmark Fault Complex as a possible hard-linked, accommodation cross fault that developed along the Sørøy-Ingøya shear zone. This brittle fault decoupled the western Finnmark Platform from the southwesternmost Nordkapp basin and merged with the Måsøy Fault Complex in Carboniferous times. Seismic
Technology development of protein rich concentrates for nutrition in extreme conditions using soybean and meat by-products.

PubMed

Kalenik, Tatiana K; Costa, Rui; Motkina, Elena V; Kosenko, Tamara A; Skripko, Olga V; Kadnikova, Irina A

2017-01-01

There is a need to develop new foods for participants of expeditions in extreme conditions, which must be self-sufficient. These foods should be light to carry, with a long shelf life, tasty and with high nutrient density. Currently, protein sources are limited mainly to dried and canned meat. In this work, a protein-rich dried concentrate suitable for extreme expeditions was developed using soya, tomato, milk whey and meat by-products. Protein concentrates were developed using minced beef liver and heart, dehydrated and mixed with a soya protein-lycopene coagulate (SPLC) obtained from a solution prepared with germi- nated soybeans and mixed with tomato paste in milk whey, and finally dried. The technological parameters of pressing SPLC and of drying the protein concentrate were optimized using response surface methodology. The optimized technological parameters to prepare the protein concentrates were obtained, with 70:30 being the ideal ratio of minced meat to SPLC. The developed protein concentrates are characterized by a high calorific value of 376 kcal/100 g of dry product, with a water content of 98 g·kg-1, and 641-644 g·kg-1 of proteins. The essential amino acid indices are 100, with minimum essential amino acid content constitut- ing 100-128% of the FAO standard, depending on the raw meat used. These concentrates are also rich in micronutrients such as β-carotene and vitamin C. Analysis of the nutrient content showed that these non-perishable concentrates present a high nutritional value and complement other widely available vegetable concentrates to prepare a two-course meal. The soups and porridges prepared with these concentrates can be classified as functional foods, and comply with army requirements applicable to food products for extreme conditions.
ROC-ing along: Evaluation and interpretation of receiver operating characteristic curves.

PubMed

Carter, Jane V; Pan, Jianmin; Rai, Shesh N; Galandiuk, Susan

2016-06-01

It is vital for clinicians to understand and interpret correctly medical statistics as used in clinical studies. In this review, we address current issues and focus on delivering a simple, yet comprehensive, explanation of common research methodology involving receiver operating characteristic (ROC) curves. ROC curves are used most commonly in medicine as a means of evaluating diagnostic tests. Sample data from a plasma test for the diagnosis of colorectal cancer were used to generate a prediction model. These are actual, unpublished data that have been used to describe the calculation of sensitivity, specificity, positive predictive and negative predictive values, and accuracy. The ROC curves were generated to determine the accuracy of this plasma test. These curves are generated by plotting the sensitivity (true-positive rate) on the y axis and 1 - specificity (false-positive rate) on the x axis. Curves that approach closest to the coordinate (x = 0, y = 1) are more highly predictive, whereas ROC curves that lie close to the line of equality indicate that the result is no better than that obtained by chance. The optimum sensitivity and specificity can be determined from the graph as the point where the minimum distance line crosses the ROC curve. This point corresponds to the Youden index (J), a function of sensitivity and specificity used commonly to rate diagnostic tests. The area under the curve is used to quantify the overall ability of a test to discriminate between 2 outcomes. By following these simple guidelines, interpretation of ROC curves will be less difficult and they can then be interpreted more reliably when writing, reviewing, or analyzing scientific papers. Copyright © 2016 Elsevier Inc. All rights reserved.
Speech-Act and Text-Act Theory: "Theme-ing" in Freshman Composition.

ERIC Educational Resources Information Center

Horner, Winifred B.

In contrast to a speech-act theory that is limited by a simple speaker/hearer relationship, a text-act theory of written language allows for the historical or personal context of a writer and reader, both in the written work itself and in the act of reading. This theory can be applied to theme writing, essay examinations, and revision in the…
Computed torque control of a free-flying cooperat ing-arm robot

NASA Technical Reports Server (NTRS)

Koningstein, Ross; Ullman, Marc; Cannon, Robert H., Jr.

1989-01-01

The unified approach to solving free-floating space robot manipulator end-point control problems is presented using a control formulation based on an extension of computed torque. Once the desired end-point accelerations have been specified, the kinematic equations are used with momentum conservation equations to solve for the joint accelerations in any of the robot's possible configurations: fixed base or free-flying with open/closed chain grasp. The joint accelerations can then be used to calculate the arm control torques and internal forces using a recursive order N algorithm. Initial experimental verification of these techniques has been performed using a laboratory model of a two-armed space robot. This fully autonomous spacecraft system experiences the drag-free, zero G characteristics of space in two dimensions through the use of an air cushion support system. Results of these initial experiments are included which validate the correctness of the proposed methodology. The further problem of control in the large where not only the manipulator tip positions but the entire system consisting of base and arms must be controlled is also presented. The availability of a physical testbed has brought a keener insight into the subtleties of the problem at hand.
"Scratch"ing below the Surface: Mathematics through an Alternative Digital Lens?

ERIC Educational Resources Information Center

Calder, Nigel; Taylor, Merilyn

2010-01-01

A key element in the examination of how students process mathematics through digital technologies is considering the ways that digital pedagogical media might influence the learning process. How might students' understanding emerge through engagement in a digital-learning environment? Interactive software that has cross-curricula implications and…
Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis.

PubMed

Greenwood, Erin; Wrenn, Emma D; Cheung, Kevin J

2017-02-27

The properties of stem cells that participate in mammary gland branching morphogenesis remain contested. Reporting in Nature, Scheele et al. (2017) establish a model for post-pubertal mammary branching morphogenesis in which position-dependent, lineage-restricted stem cells undergo cell mixing in order to contribute to long-term growth. Copyright © 2017 Elsevier Inc. All rights reserved.
OGLE-ing the Magellanic system: stellar populations in the Magellanic Bridge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skowron, D. M.; Jacyszyn, A. M.; Udalski, A.

We report the discovery of a young stellar bridge that forms a continuous connection between the Magellanic Clouds. This finding is based on number density maps for stellar populations found in data gathered by OGLE-IV that fully cover over 270 deg{sup 2} of the sky in the Magellanic Bridge area. This is the most extensive optical survey of this region to date. We find that the young population is present mainly in the western half of the MBR, which, together with the newly discovered young population in the eastern Bridge, form a continuous stream of stars connecting both galaxies alongmore » δ ∼ –73.5 deg. The young population distribution is clumped, with one of the major densities close to the SMC and the other fairly isolated and located approximately mid-way between the Clouds, which we call the OGLE island. These overdensities are well matched by H I surface density contours, although the newly found young population in the eastern Bridge is offset by ∼2 deg north from the highest H I density contour. We observe a continuity of red clump stars between the Magellanic Clouds which represent an intermediate-age population. Red clump stars are present mainly in the southern and central parts of the Magellanic Bridge, below its gaseous part, and their presence is reflected by a strong deviation from the radial density profiles of the two galaxies. This may indicate either a tidal stream of stars, or that the stellar halos of the two galaxies overlap. On the other hand, we do not observe such an overlap within an intermediate-age population represented by the top of the red giant branch and the asymptotic giant branch stars. We also see only minor mixing of the old populations of the Clouds in the southern part of the Bridge, represented by the lowest part of the red giant branch.« less
Empowering Learners as the Owners of Feedback while YouTube-ing

ERIC Educational Resources Information Center

Ng, Huey Zher; Hussain, Raja Maznah Raja

2009-01-01

Purpose: The application of a new technology (YouTube) can help lecturers in solving some of the issues related to workload and shifts support to students by giving them more responsibilities in their assessment. The purpose of this paper is to re-characterize the role of the students in the assessment process. Design/methodology/approach:…

DMD: a digital light processing application to projection displays

NASA Astrophysics Data System (ADS)

Feather, Gary A.

1989-01-01

Summary Revolutionary technologies achieve rapid product and subsequent business diffusion only when the in- ventors focus on technology application, maturation, and proliferation. A revolutionary technology is emerg- ing with micro-electromechanical systems (MEMS). MEMS are being developed by leveraging mature semi- conductor processing coupled with mechanical systems into complete, integrated, useful systems. The digital micromirror device (DMD), a Texas Instruments invented MEMS, has focused on its application to projec- tion displays. The DMD has demonstrated its application as a digital light processor, processing and produc- ing compelling computer and video projection displays. This tutorial discusses requirements in the projection display market and the potential solutions offered by this digital light processing system. The seminar in- cludes an evaluation of the market, system needs, design, fabrication, application, and performance results of a system using digital light processing solutions.
What Is Cardiac Rehabilitation?

MedlinePlus

... lets you work longer and harder. • Possibly begin strength training, if your doctor says you can. • Have your ... heartinsight.org . Connect with others sharing similar journeys with heart disease and stroke by join-ing our Support Network ...
Defending Against Biological and Chemical Attacks

DTIC Science & Technology

2010-08-01

addition, we field integrated installation consequence management response capabilities to select installations both at home and abroad. Just as...decon- tamination, like self-decontaminating or strippable coat- ings for vehicles; we are developing technologies to focus decontamination on the
Changes in nitrogen isotope ratios in estuarine biota following nutrient reductions to Narragansett Bay

EPA Science Inventory

Increased nutrient inputs globally have resulted in widespread eutrophication to many coastal water bodies including Narragansett Bay. Efforts to reduce point source nitrogen load¬ings from waste water treatment facilities (WWTFs) and combined sewer overflows (CSOs) started i...
Motorcycle accident cause factors and identification of countermeasures. Volume 1 : technical report

DOT National Transportation Integrated Search

1981-01-01

This report presents the data and find~ings from the on-scene, in-depth : investigations of 900 motorcycle accidents and the analysis of 3600 traffic : accident reports of motorcycle accidents in the same study area. : Comprehensive data were collect...
8. VIEW EASTNORTHEAST OF TRANSFORMER BAYS AND SUBSTATION; BUILDING 8 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. VIEW EAST-NORTHEAST OF TRANSFORMER BAYS AND SUB-STATION; BUILDING 8 IS AT EXTREME LEFT CENTER; BUILD-ING 50 IS VISIBLE AT LEFT CENTER BEHIND BUILDING 8 - Scovill Brass Works, 59 Mill Street, Waterbury, New Haven County, CT
Looking north at uing press of the submerged arc weld ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking north at u-ing press of the submerged arc weld (saw) line of the main pipe mill building, bay 7. - U.S. Steel National Tube Works, Main Pipe Mill Building, Along Monongahela River, McKeesport, Allegheny County, PA
Flexible Wing Designs with Sensor Control Feedback for Demonstration on the X-56A (MUTT)

NASA Technical Reports Server (NTRS)

Ginn, Starr

2012-01-01

Presenting an overview of the research DFRC is planning within the Subsonic Fixed Wing (SFW) Light Weight Airframes and Propulsion. Describ ing our TRL maturation and new research going forward using the X-56A as a validation testbed.
Soil Bioengineering - Major Gully Washout Repair, Silverhill Airfield, Baldwin County, Alabama

DTIC Science & Technology

1991-09-01

commercially available species: Pensacola bahia- grass (Paspalum notatum), bermudagrass ( Cynodon dactylon), Abbruzzi ryegrass (Lobium multiflorum), and...surrounding area was not inhibited. Fertiliz- ing, liming , and mulching recommendations were made after eval- uation of the soil analysis. Two (2) types of
Speciation of the Bioaccessible Fraction of Arsenic in Rice using IC-ICP-MS

EPA Science Inventory

Dietary arsenic exposure occurs mainly through drinking water and food; therefore, both aspects should be incorporated into any aggregate exposure assessment. Drinking water exposures are predominantly inorganic arsenic (AsIng) while dietary exposures are made up of a diverse se...
Army Transitions Hybrid Electric Technology to FCS Manned Ground Vehicles

DTIC Science & Technology

2007-12-01

completely new way of maneuvering on the battlefield. The system’s advanced energy storage, power generation, regenerative braking and power management... categories , including mixing, coat- ing and winding; electrolyte filling; cir- cuit breaker bussing and closing; electri- cal formation; and battery
Responding to Environmental Challenges in Central Asia and the Caspian Basin

DTIC Science & Technology

2001-03-01

regional environment, political tension, economic destabilization and loss, to rendering large agricultural areas unsuitable for cultivation as...large-scale deforesta tion and inappropriate farm ing practices, particularly the cultivation of marginal lands without soil conserva tion measures
The Metabolic Basis of Cystinosis

DTIC Science & Technology

1981-05-12

glucose, amino acids and other organic acids appear. The present- ing symptoms of the disease— polyuria , polydipsia and recurrent unexplained fevers are... polyuria and polydypsia which results make children with the disease extremely susceptible to dehydration. This vulnerability to dehydration explains
Space-Based Solar Power: A Technical, Economic, and Operational Assessment

DTIC Science & Technology

2015-04-01

reports also address alternative and renew- able sources such as biomass, wind, geothermal , and solar (thermal and photovoltaic), which are becom- ing...2025 using solar, wind, biomass, and geothermal energy generation technologies.86 Table 3. Army Sites for Terrestrial Solar Photovoltaic Power
Marginal Pipeline Costs of Enlisted Personnel.

DTIC Science & Technology

1979-12-03

printing, cleaning supplies , organizational equipment for train- ing support, barracks furnishings, motor pools and various other items. (USMC: MC... cleaning , supplies , and related items. 11-26 C. ARMY MISSION/SUPPORT COSTS The Army accepted 124,000 active NPS accessions in FY1978. These
Science under duress

NASA Astrophysics Data System (ADS)

2016-11-01

In the first half of the 20th century, devotion to Marx's "one science" contributed to the deaths of millions of ordinary Russians. How this happened is the subject of Stalin and the Scientists: a History of Triumph and Tragedy by Simon Ings.
Defense Manpower Policies in Northern and Central European NATO.

DTIC Science & Technology

1980-02-01

in the Netherlands generally falling into the follow- ing categories: breadwinners , those personally indispensable, those holding ecclesiastical...in The Military Balance 1977/78, pp. 104-105. Indeed there is only limited utility in comparing just peacetime strengths, since in crisis or conflict
Beyond Reason

ERIC Educational Resources Information Center

Grabar, Mary

2012-01-01

The agenda of "A Crucible Moment: College Learning & Democracy's Future," "commissioned," "funded," and "nurtured" by the U.S. Department of Education, is nothing less than an attempt to implement a "transformation" of America by "transform[ing] current academic norms about what counts as…
Transforming Leadership Identity in a Virtual Environment: Learning about the Leading Self

ERIC Educational Resources Information Center

Rusch, Edith A.; Brunner, C. Cryss

2013-01-01

Schein contends that "unless leaders become learners themselves … acknowledg[ing] vulnerabilities and uncertainties--then transformational learning will never take that lead to transformative learning, the authors engaged educational leadership doctoral students in an 'Experimental Simulation', using masked identities in a virtual…
Flight Attendant Fatigue

DTIC Science & Technology

2007-07-01

differed in particulars, results indicated that they produced consistent results. This analysis was offered as a first step toward the further...12 sECTION 4: CREw sCHEdUlINg ANAlYsIs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Chapter...Airlines Schedules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3. Additional Schedules Analysis

PERFLUORINATED COMPOUNDS (PFCs) IN SERUM OF CATS – LINKAGE TO INDOOR EXPOSURES.

EPA Science Inventory

The PFCs have been used in a wide range of consumer, including residential, products (e.g., stain-resistant coatings for carpets and upholstery). Carbon-fluoride bonds are highly stable, mak-ing PFCs extremely resistant to biodegradation. Thus, PFCs have become globally distribut...
Spectrum of Sanity.

ERIC Educational Resources Information Center

Sartorius, Tara Cady

2002-01-01

Presents information on the life and career of Walter Inglis Anderson. Focuses on his bouts of mental illness which influence his works of art. Provides an explanation of his artwork, "Chickens." Includes lessons in social studies, visual arts, psychology, and language arts. (CMK)
Numerical Analysis for Relevant Features in Intrusion Detection (NARFid)

DTIC Science & Technology

2009-03-01

Rosenblatt, Frank. Principles of Neurodynamics : Perceptrons and the Theory of Brain Mechanisms. Spartan Books, Washington DC, 1961. 74. Rossey, Lee M., Robert...editors), Parallel distributed process- ing: Explorations in the microstructure of cognition , Volume 1: Foundations. MIT Press, 1986. 76. Russel, Stuart and
78 FR 24779 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Telemanagement Forum

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... names: China Comservice Software Technology Co., Ltd. to China Communication Service Application and... GmbH, Potsdam, GERMANY; e. Services Africa Limited, Accra, GHANA; Cognity Consulting, Maroussi, GREECE... Services Sdn Bhd, KL Sentral, MALAYSIA; ING Bank N.V., Amsterdam, NETHERLANDS; Ultrafast Fibre Limited...
Primitives for Active Internet Topology Mapping: Toward High-Frequency Characterization

DTIC Science & Technology

2010-11-03

that a tension exists between the two conflict- ing goals of reducing probing traffic and capturing dynamic forwarding paths. Many networks deploy...perform alias resolution to future work. Acknowledgments The authors would like to thank Young Hyun, k. claffy and CAIDA for measurement
State-wide Conservation Forum to Facilitate Cooperative Conservation

DTIC Science & Technology

2007-03-01

leaf pine ecosystem that is home to the red-cockaded woodpecker (RCW), an endangered species. After significant train- ing restrictions were imposed...ranking). Caroline and Essex counties were rural, sparsely populated areas, dominated by forestland and small farms. Both counties are experiencing
Grand Challenges for Disaster Reduction

DTIC Science & Technology

2005-06-01

6—Promote risk-wise behavior. Develop and apply principles of economics and human behavior to enhance communications, trust, and understand- ing...Challenges for Disaster Reduction Promote Risk-Wise Behavior. Develop and apply principles of economics and human behavior to enhance communications
Antibodies to Liposomal, Phosphatidylcholine and Phosphatidylsulfocholine

DTIC Science & Technology

1990-01-01

Biochim. Biophys. tidylcholine have also been induced by immuniz- Acta, 689: 319-326. ing mice with bromelain -treated mouse erythrocytes (Cox BISSERET, P...with lysolecithin and sphingomyelin, thus bromelain -modified RBC are specifically inhibited by a common indicating specificity for the phosphocholine
Coaching for Better (Software) Buying Power in an Agile World

DTIC Science & Technology

2013-06-01

believes that DevOps , the process of warfighters and developers work- ing together throughout the project, is superior to volumes of detailed...ride on the Consolidated Afloat Networks and Enterprise Services (CANES) infrastructure. This transformation is not easy. It requires a change in
Current and emerging biologics for ulcerative colitis.

PubMed

Park, Sung Chul; Jeen, Yoon Tae

2015-01-01

Conventional medical treatment for ulcerative colitis can have limited efficacy or severe adverse reactions requiring additional treatment or colectomy. Hence, different biological agents that target specific immunological pathways are be-ing investigated for treating ulcerative colitis. Anti-tumor necrosis factor (TNF) agents were the first biologics to be used for treating inflammatory bowel disease. For example, infliximab and adalimumab, which are anti-TNF agents, are be-ing used for treating ulcerative colitis. Recently, golimumab, another anti-TNF agent, and vedolizumab, an anti-adhesion therapy, have been approved for ulcerative colitis by the U.S. Food and Drug Administration. In addition, new medications such as tofacitinib, a Janus kinase inhibitor, and etrolizumab, another anti-adhesion therapy, are emerging as therapeutic agents. Therefore, there is a need for further studies to select appropriate patient groups for these biologics and to improve the outcomes of ulcerative colitis treatment through appropriate medical usage.
Maintaining Low Voiding Solder Die Attach for Power Die While Minimizing Die Tilt

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamm, Randy; Peterson, Kenneth A.

2015-10-01

This paper addresses work to minimize voiding and die tilt in solder attachment of a large power die, measuring 9.0 mm X 6.5 mm X 0.1 mm (0.354” x 0.256” x 0.004”), to a heat spreader. As demands for larger high power die continue, minimizing voiding and die tilt is of interest for improved die functionality, yield, manufacturability, and reliability. High-power die generate considerable heat, which is important to dissipate effectively through control of voiding under high thermal load areas of the die while maintaining a consistent bondline (minimizing die tilt). Voiding was measured using acoustic imaging and die tiltmore » was measured using two different optical measurement systems. 80Au-20Sn solder reflow was achieved using a batch vacuum solder system with optimized fixturing. Minimizing die tilt proved to be the more difficult of the two product requirements to meet. Process development variables included tooling, weight and solder preform thickness.« less
Low-Level Laser Therapy and Cryotherapy as Mono- and Adjunctive Therapies for Achilles Tendinopathy in Rats.

PubMed

Haslerud, Sturla; Lopes-Martins, Rodrigo Alvaro Brandão; Frigo, Lúcio; Bjordal, Jan Magnus; Marcos, Rodrigo Labat; Naterstad, Ingvill Fjell; Magnussen, Liv Heide; Joensen, Jon

2017-01-01

Low-level laser therapy (LLLT) and cryotherapy are widely used treatments in the acute phase of tendon injury. The aim of this study was to investigate the interaction of these two treatments on tendon inflammation and mechanical properties. Six groups of six Wistar rats were used in this study. The Achilles tendons of the healthy control group were not subjected to injury or treatment. The tendons of the injured nontreated group (ING) were injured, but not treated. The remaining four groups were injured and subjected to LLLT, cryotherapy, LLLT first/cryotherapy, or cryotherapy first/LLLT. All treatments were performed at 1 h post-trauma. Inflammatory mediators, tendon histology, and biomechanical properties were assessed at 24 h post-trauma by comparing the treatment groups with the ING. In all treatment groups, the inflammatory process shifted in an anti-inflammatory direction compared with the ING. Significant alterations in cytokine expression were found in only the LLLT group (↓IL-1β) and the combined intervention groups (↓IL-1β, ↓TNF-α, ↑IL-6). It was also found that cryotherapy followed by LLLT was the only treatment that significantly (p < 0.05) improved the biomechanical parameters of force (N) and displacement (mm) at the tendon rupture and corresponded with the best histological scores of all of the treatment groups. Our results demonstrate that cryotherapy in combination with LLLT can produce an anti-inflammatory "add-on" effect. The order of therapy administration seems essential, as superior histology and biomechanical results were found in the cryotherapy first/LLLT group.
Managing, Leading, and Bossing

DTIC Science & Technology

2011-08-01

but who is self satisfied and complacent in their role may be headed towards being a boss. Recommendations for Avoiding the Boss Syndrome Over...based evidence is available to support important decision and processes. Information on hir- ing, leadership, training, rewards, and burnout is
Black Lights: Chaos, Complexity, and the Promise of Information Warfare

DTIC Science & Technology

1997-01-01

control— cybernetics—and the etymology of control, a term which comes from the Latin contrarotulare, mean- ing to mark similarities and differences...in the brain and central nervous system. Chemistry domi- nated life processes for four billion years until primitive electronics became important when
Functional Cardiorespiratory Toxicity Screening of Candidate Antiparasitic Drugs and Antidotes for Chemical Poisons. Study of the Effects of Drugs Upon the Cardiovascular and Respiratory Systems

DTIC Science & Technology

1988-06-01

and Hamilton, 1971). This lecithin -contain- ing substance keeps alveoli from collapsing and allows larger Increases in lung volume to occur without a...1979; Caldwell and Nash, 1977). Use of mefioqulne following chloroquine administration where resistance to chioroquine therapy might arise is a distinct
Personal, Situational, and Organizational Determinants of Navy Enlisted Attrition

DTIC Science & Technology

1980-06-01

of regular high school instruction. The GED test battery contains five testsz writing skills, social studies, science, reading skills, and mathematics ...expanded apprentice train- ing program for airmen and seamen might, ceteris paribus, bring the GENDET attrition rate closer to acceptable lvels . 13 ] KN
The Acme of Skill: Nonkinetic Warfare

DTIC Science & Technology

2008-05-01

results are mixed. For the im- mense cost that often accompanies war, the returns of war are not guaranteed. On nonkinetic operations, it may appear that...ing, together with other kinetic capabilities such as emphasizing irregular operations, increasing ground troop levels, and recruiting foreign
Somalia

DTIC Science & Technology

2013-04-01

Full event data is available online . 2 fied assault on Al Shabaab positions outside Mogadishu, the group was already engaging in sporadic...uting to militants’ further radicalisation . In Somalia’s north -east, Al Shabaab militants have been reportedly operat- ing and establishing bases in
MIZEX. A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. II. A Science Plan for a Summer Marginal Ice Zone Experiment in the Fram Strait/Greenland Sea: 1984.

DTIC Science & Technology

1983-05-01

size and thickness characteris- tics. N’ore complete analysis will require combin- ing ice data with data obtained by the oceano - graphic... sol concentration and microwave brightness tem- perature. A long-range aircraft and a light aircraft Hying from Spitzbergen will study mesoscale
Long Term Monitoring of Broken and Seated Pavements

DOT National Transportation Integrated Search

2002-05-01

This report presents details of a study conducted to evaluate the long term performance of asphalt overlays on broken and seated : (B/S) concrete p avements, us ing field expe riments. Th e primary p urpose o f this study is to evaluate the effective...

Reform of the Method for Evaluating the Teaching of Medical Linguistics to Medical Students

ERIC Educational Resources Information Center

Zhang, Hongkui; Wang, Bo; Zhang, Longlu

2014-01-01

Explorating reform of the teaching evaluation method for vocational competency-based education (CBE) curricula for medical students is a very important process in following international medical education standards, intensify ing education and teaching reforms, enhancing teaching management, and improving the quality of medical education. This…
Data_Flood: Helping the Navy Address the Rising Tide of Sensor Information

DTIC Science & Technology

2014-01-01

the influx of data . This report describes the Navy’s “ big data ” challenge and outlines potential solutions involv- ing changes along four dimensions...ChAPTer One Big Data : Challenges and Opportunities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 What Is “ Big Data ...3 The Navy’s Big Data
Modeled Estimates of Soil and Dust Ingestion Rates for Children

EPA Science Inventory

Daily soil/dust ingestion rates typically used in exposure and risk assessments are based on tracer element studies, which have a number of limitations and do not separate contributions from soil and dust. This article presents an alternate approach of modeling soil and dust inge...
All the Elements of National Power

DTIC Science & Technology

2016-03-01

sustainable peace. Anachronistic stereotypes regarding gender roles make for bad policy when provid- ing for the common defense. Often consigned to...That resolution “called for women’s equal participation with men and their full involvement in all efforts for the maintenance and promotion of
U.S. EPA, Pesticide Product Label, KERNEL GUARD, 03/01/1989

EPA Pesticide Factsheets

2011-04-21

... ". . • clot.Jai... ..d eII., ... ... P ... _ol oloUai •• _n 4_ing u_ ••• t.... l •• n~'" •• p.,. .. t.el~ .. •. I,.oe hou"'old art.iol.o. Clot..bi....4 protoct.1". "YA~"" ta .. ...
Modeling Human Visual Perception for Target Detection in Military Simulations

DTIC Science & Technology

2009-06-01

incorrectly, is a subject for future research. Possibly, one could exploit the Recognition-by-Components theory of Biederman (1987) and decompose the...Psychophysiscs, 55, 485-496. Biederman , I. (1987). Recognition-by-components: A theory of human image understand- ing. Psychological Review, 94, 115-147
Differential expression of genes in fetal brain as a consequence of maternal protein deficiency and nematode infection.

PubMed

Haque, Manjurul; Starr, Lisa M; Koski, Kristine G; Scott, Marilyn E

2018-01-01

Maternal dietary protein deficiency and gastrointestinal nematode infection during early pregnancy have negative impacts on both maternal placental gene expression and fetal growth in the mouse. Here we used next-generation RNA sequencing to test our hypothesis that maternal protein deficiency and/or nematode infection also alter the expression of genes in the developing fetal brain. Outbred pregnant CD1 mice were used in a 2×2 design with two levels of dietary protein (24% versus 6%) and two levels of infection (repeated sham versus Heligmosomoides bakeri beginning at gestation day 5). Pregnant dams were euthanized on gestation day 18 to harvest the whole fetal brain. Four fetal brains from each treatment group were analyzed using RNA Hi-Seq sequencing and the differential expression of genes was determined by the edgeR package using NetworkAnalyst. In response to maternal H. bakeri infection, 96 genes (88 up-regulated and eight down-regulated) were differentially expressed in the fetal brain. Differentially expressed genes were involved in metabolic processes, developmental processes and the immune system according to the PANTHER classification system. Among the important biological functions identified, several up-regulated genes have known neurological functions including neuro-development (Gdf15, Ing4), neural differentiation (miRNA let-7), synaptic plasticity (via suppression of NF-κβ), neuro-inflammation (S100A8, S100A9) and glucose metabolism (Tnnt1, Atf3). However, in response to maternal protein deficiency, brain-specific serine protease (Prss22) was the only up-regulated gene and only one gene (Dynlt1a) responded to the interaction of maternal nematode infection and protein deficiency. In conclusion, maternal exposure to GI nematode infection from day 5 to 18 of pregnancy may influence developmental programming of the fetal brain. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Accurate defect die placement and nuisance defect reduction for reticle die-to-die inspections

NASA Astrophysics Data System (ADS)

Wen, Vincent; Huang, L. R.; Lin, C. J.; Tseng, Y. N.; Huang, W. H.; Tuo, Laurent C.; Wylie, Mark; Chen, Ellison; Wang, Elvik; Glasser, Joshua; Kelkar, Amrish; Wu, David

2015-10-01

Die-to-die reticle inspections are among the simplest and most sensitive reticle inspections because of the use of an identical-design neighboring-die for the reference image. However, this inspection mode can have two key disadvantages: (1) The location of the defect is indeterminate because it is unclear to the inspector whether the test or reference image is defective; and (2) nuisance and false defects from mask manufacturing noise and tool optical variation can limit the usable sensitivity. The use of a new sequencing approach for a die-to-die inspection can resolve these issues without any additional scan time, without sacrifice in sensitivity requirement, and with a manageable increase in computation load. In this paper we explore another approach for die-to-die inspections using a new method of defect processing and sequencing. Utilizing die-to-die double arbitration during defect detection has been proven through extensive testing to generate accurate placement of the defect in the correct die to ensure efficient defect disposition at the AIMS step. The use of this method maintained the required inspection sensitivity for mask quality as verified with programmed-defectmask qualification and then further validated with production masks comparing the current inspection approach to the new method. Furthermore, this approach can significantly reduce the total number of defects that need to be reviewed by essentially eliminating the nuisance and false defects that can result from a die-to-die inspection. This "double-win" will significantly reduce the effort in classifying a die-to-die inspection result and will lead to improved cycle times.
America on the Ice. Antarctic Policy Issues

DTIC Science & Technology

1990-01-01

Prime Minister- Mahatir Mohamad-fired the open- ing volleys during a UN General Assembly speech in September of that year. He noted, "Henceforth all...problem of unin- habited lands." According to Mahatir , the Antarctic conti- nent clearly qualified for such consideration and, not withstanding the
Avoiding the Slippery Slope: Conducting Effective Interventions

DTIC Science & Technology

2013-06-01

internal memo from NATO headquarters in Zagreb , Croatia discussed these options in detail. Withdraw- ing more than 40,000 troops from an active war zone...Interoffice Memorandum, UN Peace Forces, HQ Zagreb to Special Representative of the Secretary-General, July 17, 1995, Lester Pearson Canadian Peacekeeping
Pressure and Temperature Studies of Glass Properties Related to Vibrational Spectra.

DTIC Science & Technology

1974-12-01

enters the glass, VST be- comes increasingly more positive and the anomaly de- 765 creases. Since Raman-active modes have not been ex- amined under...more ordered angular position and (ii) the network becomes increas- ingly disrupted. Our results are consistent with this .not appreciably vary with
Toxicity in Rhesus Monkeys Following Administration of the 8-Aminoquinoline 8-[(4-amino-l-methylbutyl)amino]-5(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511)

DTIC Science & Technology

2008-09-01

been synthesized) [17,18]. The rhesus monkey has also shown consistent MHb elevation follow- ing exposure to benzocaine as well as the 8...anesthetic-induced methemoglobinemia and sulfhemo- globinemia in macaques: a comparison of benzocaine and lido- caine. J Appl Toxicol 1995;15:153–158. 20
The Fabrication of Arrays of Single Ions in Silicon via Ion Implantation

DTIC Science & Technology

2014-02-01

Requirement of optical nonlinearity for photon count- ing. Physical Review A, 65:042304, 2002. [108] Seth Lloyd and Samuel L. Braunstein. Quantum...defects in metals. Journal of Physics F: Metal Physics, 3(2):295, 1973. [361] George D. Watkins . Intrinsic defects in silicon. Materials Science in Semicon
Multiobjective Topology Optimization of Energy Absorbing Materials

DTIC Science & Technology

2015-08-01

absorbing liner for equestrian helmets. Part I: layered foam liner . Mater Des 30(9):3405–3413 Sethian J, Wiegmann A (2000) Structural boundary design via...Army Research Laboratory Wildman RA, Weile DS (2007) Geometry reconstruction of conduct- ing cylinders using genetic programming. IEEE Trans Antennas
40 CFR 205.54-1 - Low speed sound emission test procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... beyond the permissible end zone, unload the vehicle and/or increase the approach rpm in 100 rpm... rpm beyond the permissible end zone, unload the vehicle and/or increase the approach rpm in 100 rpm... example, temperature, humidity, and barometric pressure). (ii) Proper signal levels, terminat-ing...
75 FR 66761 - Agency Information Collection Activities: Final Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... strengthen sanctions against Iran, the Act contains language prohibiting Ex-Im Bank from: Authoriz[ing] any... refiner that continues to: (A) Provide Iran with significant refined petroleum resources; (B) materially contribute to Iran's capability to import refined petroleum resources; or (C) allow Iran to maintain or...
Dynamic Interactions for Network Visualization and Simulation

DTIC Science & Technology

2009-03-01

projects.htm, Site accessed January 5, 2009. 12. John S. Weir, Major, USAF, Mediated User-Simulator Interactive Command with Visualization ( MUSIC -V). Master’s...Computing Sciences in Colleges, December 2005). 14. Enrique Campos -Nanez, “nscript user manual,” Department of System Engineer- ing University of
Thinking about Educational Technology and Creativity

ERIC Educational Resources Information Center

Spector, J. Michael

2016-01-01

The 2016 National Educational Technology Plan mentions fostering creativity, collaboration, leadership, and critical thinking while engaging learners in complex, real-world challenges through a project-based learning approach (see http://tech.ed.gov/netp/learn ing/). The Partnership for 21st Century Learning (P21; see…
U.S. EPA, Pesticide Product Label, COSSMAN PATIO PELLETS, 12/15/1969

EPA Pesticide Factsheets

2011-04-14

... F 'iE."I ,'" I, • r !c't',:ing 11" p.>rti,le ,.,j hait. The S,ln'!:' ~ijt parti,:e :!,1'0' ki.: ' .. t ' ' "et're it 1,'ses i's etfe,·tiveile~". S(dttl'!- li,,:1tlv '1, ~rd •. ·.I"l·; ~". ...
Assessment of CFD Modeling Capability for Hypersonic Shock Wave Boundary Layer Interactions

DTIC Science & Technology

2015-11-30

preparation. 8 Point of Contact Dr. John Spyropoulos NAVAIR 22195 Elmer Road Building 106, Floor 2, Room 209B Patuxent River, MD 20670 Email...Dynamics, Krieger Publish- ing Company, Malabar, Florida, 1965. [15] Millikan, R. and White, D., "Systematics of Vibrational Relaxation," Journal of

A Proposed Logistics Career Development Model.

DTIC Science & Technology

1986-09-01

1 Opportunity to express teelinas ing others (younger employees) about mid-ite ( anguish defeat. 2 Training for updating and integrating limited time... SPSS Incorporated. SPSSx User’s Guide (Second Edition). New York: McGraw-Hill Book Company, 1986. 48. Snyder William P. "Educating Military Officers
Major Federal Research and Development Agencies are Implementing the Patent and Trademark Amendments of 1980.

DTIC Science & Technology

1984-02-28

foreign intelligence or counter- intelligence activities determines that restrict- ing or eliminating the right to retain title to any sub- ject...qzired clause, giving rights in their inventions to small busines and nonprofit subcontractors. However, we are persuaded that the lSection 9 (42 U.S.C
Preliminary Modeling of Acoustic Detection Capability for the Drifting Arctic Monitoring System

DTIC Science & Technology

2015-02-01

required. Active heating through chemical means is also a possibility, but will be avoided if possible due to the added complexity. The maximum buoy...2015-R021 [24] Engen , Øyvind, Gjengedal, Jakob Andreas, Faleide, Jan Inge, Kristoffersen, Yngve, and Eldholm, Olav (2009), Seismic stratigraphy and
Global foot-and-mouth disease research update and gap analysis: 2 - epidemiology, wildlife and economics

USDA-ARS?s Scientific Manuscript database

In 2014, the Global Foot-and-mouth disease Research ings in the fields of (i) epidemiology, (ii) wildlife and (iii) Alliance (GFRA) conducted a gap analysis of foot-and- economics. Although the three sections, epidemiology, wildlife and economics are presented as separate entities, the fields are ...
Date palm production and pest management challenges

USDA-ARS?s Scientific Manuscript database

Abstract: Date palm, Phoenix dactylifera, is a monocotyledonous species belong- ing to the palm family (Arecaceae or Palmae) which is perennial and dioecious and cultivated mostly in the arid regions of the world. Date palm is important to the agrarian economy of several countries, with the ability ...
Biological Correlates of Cognitive, Sensory and Motor Abilities

DTIC Science & Technology

1975-04-01

specialized, histologically modified ends of sensory nerve fibers. The receptors are designed to respond to a particular form of energy at a much lower...consider the comparativ ■ approach as having rich potential. It is believed to be the only currently available means of definitely establish- ing
Resampling-Based Gap Analysis for Detecting Nodes with High Centrality on Large Social Network

DTIC Science & Technology

2015-05-22

University, Shiga, Japan kimura@rins.ryukoku.ac.jp 4 Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan 5 School of...second one is a network extracted from a Japanese word-of-mouth communication site for cosmetics , “@cosme”2, consist- ing of 45, 024 nodes
A Pandemic Influenza Preparedness Study: Use of Energetic Methods to Decontaminate Filtering Facepiece Respirators Contaminated with H1N1 Aerosols and Droplets (POSTPRINT)

DTIC Science & Technology

2012-06-01

have caused millions of deaths worldwide.1,2 After the Hong Kong flu pandemic of 1968, experts predicted that another pandemic was im- minent. Their...was propagated in embryonic chicken eggs followingstandard protocols.37 Virus titers were determined us- ing a tissue culture infectious dose assay
Comparative Perspectives on Futures in Education. Proceedings of the Annual Conference of the Australian Comparative and International Education Society (10th, Sydney, New South Wales, Australia, November 24-26, 1982).

ERIC Educational Resources Information Center

Liesch, James R., Ed.

The titles and authors of the 12 conference papers presented in this document are: (1) "China's Immediate Future: Renewed Cultural Borrowing" (R.F. Price); (2) "The Feminization of the Teaching Profession in Singapore" (Christine Inglis); (3) "Towards Equity and Efficiency in the Education System of Mauritius" (Helen…
The U.S. Geological Survey Land Remote Sensing Program

USGS Publications Warehouse

,

2007-01-01

The fundamental goals of the U.S. Geological Survey's Land Remote Sens-ing (LRS) Program are to provide the Federal Government and the public with a primary source of remotely sensed data and applications and to be a leader in defining the future of land remote sensing, nationally and internationally. Remotely sensed data provide information that enhance the understand-ing of ecosystems and the capabilities for predicting ecosystem change. The data promote an understanding of the role of the environment and wildlife in human health issues, the requirements for disaster response, the effects of climate variability, and the availability of energy and mineral resources. Also, as land satellite systems acquire global coverage, the program coordinates a network of international receiving stations and users of the data. It is the responsibility of the program to assure that data from land imaging satellites, airborne photography, radar, and other technologies are available to the national and global science communities.
The Service Programme of the Isaac Newton Group of Telescopes

NASA Astrophysics Data System (ADS)

Méndez, J.

2013-05-01

The Service Programme of the Isaac Newton Group of Telescopes (Roque de los Muchachos Observatory, La Palma, Spain) aims at providing astronomers with a rapid and flexible tool for obtaining small sets of observations on the William Herschel Telescope up to 8 hours. This can be used to try new ideas or complement a regular observing programme allocated on the ING telescopes, for instance. Proposals are accepted from principal investigators working in an institution located in the United Kingdom, the Netherlands or Spain, but also regardless the nationality of the host institution. A monthly deadline for application submission takes place at midnight on the last day of each month but urgent requests submitted at any time can also be accepted. Proposals are generally withdrawn from the scheme after a one year period. In this poster we provide an overview of the programme and some statistics. More information can be obtained at http://www.ing.iac.es/astronomy/service/.
What befalls the proteins and water in a living cell when the cell dies?

PubMed

Ling, Gilbert N; Fu, Ya-zhen

2005-01-01

The solvency of solutes of varying molecular size in the intracellular water of freshly-killed Ehrlich carcinoma cells fits the same theoretical curve that describes the solvency of similar solutes in a 36% solution of native bovine hemoglobin--a protein found only in red blood cells and making up 97.3% of the red cell's total intracellular proteins. The merging of the two sets of data confirms the prediction of the AI Hypothesis that key intracellular protein(s) in dying cells undergo(es) a transition from: (1) one in which the polypeptide NHCO groups assume a fully-extended conformation with relatively strong power of polarizing and orienting the bulk-phase water in multilayers; to (2) one in which most of the polypeptide NHCO groups are engaged in alpha-helical and other "introvert" conformations (see below for definition) with much weaker power in polarizing-orienting multilayers of bulk-phase water. This concordance of the two sets of data also shows that what we now call native hemoglobin--supposedly denoting hemoglobin found in its natural state in living red blood cells--, in fact, more closely resembles the water-polarizing, and -orienting intracellular proteins in dead cells. Although in the dead Ehrlich carcinoma cells as well as in the 36% solution of native hemoglobin, much of the protein's polypeptide NHCO groups are engaged in alpha-helical and other "introvert" conformation (Perutz 1969; Weissbluth 1974), both systems produce a weak but nonetheless pervasive and "long-range" water polarization and orientation. It is suggested that in both the dead Ehrlich carcinoma ascites cells and in the 36% native bovine hemoglobin solution, enough polypeptide NHCO groups assume the fully-extended conformation to produce the weak but far-reaching multilayer water polarization and orientation observed.
Genetics and language: a neurobiological perspective on the missing link (-ing hypotheses).

PubMed

Poeppel, David

2011-12-01

The paper argues that both evolutionary and genetic approaches to studying the biological foundations of speech and language could benefit from fractionating the problem at a finer grain, aiming not to map genetics to "language"-or even subdomains of language such as "phonology" or "syntax"-but rather to link genetic results to component formal operations that underlie processing the comprehension and production of linguistic representations. Neuroanatomic and neurophysiological research suggests that language processing is broken down in space (distributed functional anatomy along concurrent pathways) and time (concurrent processing on multiple time scales). These parallel neuronal pathways and their local circuits form the infrastructure of speech and language and are the actual targets of evolution/genetics. Therefore, investigating the mapping from gene to brain circuit to linguistic phenotype at the level of generic computational operations (subroutines actually executable in these circuits) stands to provide a new perspective on the biological foundations in the healthy and challenged brain.
Be(com)ing an Excellent Student: A Qualitative Study with Engineering Undergraduates

ERIC Educational Resources Information Center

Monteiro, Sílvia; Almeida, Leandro S.; Vasconcelos, Rosa M.; Cruz, José Fernando A.

2014-01-01

This study explores the factors affecting the development of academic excellence on a group of 33 high-achieving engineering students. Participants were interviewed individually to explore several personal and contextual aspects of their past and current academic pathways. The results obtained reflect three main contributions to the…
Improv(ing) the Academy: Applied Improvisation as a Strategy for Educational Development

ERIC Educational Resources Information Center

Rossing, Jonathan P.; Hoffmann-Longtin, Krista

2016-01-01

Improvisational theater training (or "improv") is a strategy employed by many business leaders and educators to cultivate creativity and collaboration amid change. Drawing on improv principles such as "Yes, And…" and "Make your scene partners look good," we explore the ways in which educational developers might apply…
Online People Tagging: Social (Mobile) Network(ing) Services and Work-Based Learning

ERIC Educational Resources Information Center

Cook, John; Pachler, Norbert

2012-01-01

Social and mobile technologies offer users unprecedented opportunities for communicating, interacting, sharing, meaning-making, content and context generation. And, these affordances are in constant flux driven by a powerful interplay between technological innovation and emerging cultural practices. Significantly, also, they are starting to…
Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect

PubMed Central

Gorham, Katrine A.; Sulbaek Andersen, Mads P.; Meinardi, Simone; Delfino, Ralph J.; Staimer, Norbert; Tjoa, Thomas; Rowland, F. Sherwood; Blake, Donald R.

2013-01-01

The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or n-pentane (p = 0.44 and 0.28, respectively) when outliers were included. In the case where outliers were removed n-pentane was found to be inversely associated with carbonylated proteins. Exhaled hydrocarbons adjusted for indoor hydrocarbon concentrations were instead found to be positively associated with air pollutants (NO, NO2 and CO), suggesting pollutant exposure is driving exhaled hydrocarbon concentrations. Given these find-ings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress. PMID:19283520
Changing Practice.

ERIC Educational Resources Information Center

Benson, Chris, Ed.

1999-01-01

This serial issue contains nine articles all on the subject of "changing practice," i.e., innovative practices of rural English teachers in the Bread Loaf Rural Teacher Network. "Byte-ing into Medieval Literature" (John Fyler) describes an online conference on medieval literature for rural high school students. "Literacy…
Sequential Changes in Alanine Metabolism Following Partial Hepatectomy in the Rat

DTIC Science & Technology

1990-11-01

complete semipurified diet for 10 days be- libitum and the second subgroup was pair-fed with HX fore and after experimentation. 5 Food was removed rats. Nine...amino acid to form ing the ketogenic pathway. Indeed, reduced ketogene - pyruvate which can enter the tricarboxylic acid (TCA) sis after partial
Motion and Structure Estimation of Manoeuvring Objects in Multiple- Camera Image Sequences

DTIC Science & Technology

1992-11-01

and Speckert [23], Gennery [24], Hallman [25], Legters and Young [26], Stuller and Krishnamurthy [27], Wu et al. [381, Matthies, Kanade, and Szeliski...26] G.R. Legters , T.Y. Young, "A mathematical model for computer image track- ing," IEEE Transactions on Pattern Analysis and Machine Intelligence

76 FR 19788 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Telemanagement Forum

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

...Telematics, Inc., Atlanta, GA; Inducta d.o.o., Zagreb, CROATIA; Infinite Infosoft Services Pvt Ltd, Gurgaon, INDIA; ING Bank N.V., Amsterdam, NETHERLANDS; integracija od-do d.o.o., Zagreb, CROATIA; Intraway Corp...; HughesTelematics to HughesTelematics, Inc., Atlanta, GA; Inducta to Inducta d.o.o., Zagreb, CROATIA...
Investigation of Methods to Predict Thermal Stratification and Its Effect on Solar Energy System Performance.

DTIC Science & Technology

1980-05-01

International Conference, Vol 1, Dhahran, Saudi Arabia (November 1975), pp 508-510. + C. W. J. Van Koppen, L. S. Fischer, and A. Dijkmans ...S. Fischer, and A. Dijkmans , "Stratification Effects in te Short and Long Term Storage of Solar Heat," Proceed- ings, 1978 meeting of Amercan Sec
The North Atlantic Treaty Organization and the European Union’s Common Security and Defense Policy: Intersecting Trajectories

DTIC Science & Technology

2011-07-01

www.consilium.europa.eu/uedocs/cmsUpload/78367.pdf. 23. Gustav Lindstrom , “Enter the EU Battlegroups,” Chaillot Paper, No. 97, February 2007, Paris, France: EU...individual human be- ing is our Benchmark. U.S. ARMY WAR COLLEGE Major General Gregg F. Martin Commandant ***** STRATEGIC STUDIES INSTITUTE Director
Investigation of Rho Signaling Pathways in 3-D Collagen Matrices with Multidimensional Microscopy and Visualization Techniques

DTIC Science & Technology

2008-03-01

most prevalent cancer among women .1 Therefore, tech- ologies to detect, classify, study, and combat breast cancer re of great significance. Among these...M. Sidani , J. Wyckoff, C. Xue, J. E. Segall, and J. Condeelis, “Prob- ing the microenvironment of mammary tumors using multiphoton microscopy,” J
Integrated Surveillance for the Next Generation Air Transportation System. Final Report of the Integrated Surveillance Study Team

DTIC Science & Technology

2008-10-31

Navigation Services Working Group Jan de Regt FAA Tony Richardson JPDO Technical Support James Roberts DoD AFFSA Eric Rolfe JPDO Air Navigation...Kirsch DHS Drew Kuepper DoD eragency Architecture and Engineering Division Jay Merkle JPDO Int Paul Polski DHS ing GroupElizabeth Lynn ye JPDO Air
On the Geometry of Visual Correspondence

DTIC Science & Technology

1994-07-01

from point and line matches. In Proc. International Conference on Computer Vision, pages 25-34, 1987. [11] 0. Faugeras and S. Maybank . Motion from...image. Proceed- ings of the Royal Society, London B, 208:385-397, 1980. (23] S. Maybank . Theory of Reconstruction from Image Motion. Springer, Berlin
Preventing Violent Extremism and "Not in My Name": Theatrical Representation, Artistic Responsibility and Shared Vulnerability

ERIC Educational Resources Information Center

Bartlett, Alice

2011-01-01

This paper draws on my own recent experience of local artistic engagement with the British government's counter-terrorism strategy, Prevent(ing Violent Extremism). "Not in My Name" uses verbatim theatre techniques to negotiate dialogue within and across communities around a controversial agenda, and has received national acclaim for its…
Never Been KIST: Tor’s Congestion Management Blossoms with Kernel-Informed Socket Transport

DTIC Science & Technology

2014-08-01

when compared to vanilla Tor. Outline of Major Contributions: We outline our major contributions as follows: – in Section 3 we discuss improvements to...experiments. We tested vanilla Tor us- ing the default CircuitPriorityHalflife of 30, the global scheduling part of KIST (without enforcing the write limits
Optimization and Persistence

DTIC Science & Technology

1997-09-01

and Ronen 1987], capital budget- ing [Brown, Clemence, Teufert, and Wood 1991], and global supply chain manage- ment [ Arntzen , Brown, Harrison, and...crew-pairing opti- mization at American Airlines," Interfaces, Vol. 21, No. 1 Oanuary- February), pp. 62-74. Arntzen , B. C.; Brown, G. G.; Harrison, T
Major Naval Operations

DTIC Science & Technology

2008-09-01

ing craft, while four combat craft (two tor- pedo craft and two light patrol craft) were captured in Port of Adabia. 5. Hartmut Zehrer, ed., Der...Collaborative planning is made possible by information technologies that allow the real-time exchange of information by voice and video . It greatly
Surface Observation Climatic Summaries for Little Rock AFB, Arkansas

DTIC Science & Technology

1991-02-01

STATE-OF-THE-ART COM- PUTER TECHNOLOGY TO SUMMARIZE WEATHER OBSERVATIONS COLLECTED FROM SELECTED MIL - ITARY, CIVILIAN, AND FOREIGN REPORTING STATIONS...PERCENT OCCURRENCE FREQUENCY ....................... E-6-1 PART F - PRESSURE (FROM HOURLY OBS) ................................... F -i-i SEA LEVEL...PRESSURE ................................................ F -2-1 ALTIMETER SETT ING ................................................. F -3-1 STATION
Information Seeking about the Military by Young Men: Findings from the 1989 Youth Attitude Tracking Study II

DTIC Science & Technology

1991-02-01

its use of high technologies and its high-caliber tram- ing in a very demanding electronic environment. The Navy’s advertising strategy is similar to...element of their advertising strategy is the use of direct mail campaigns. The content of broadcast and direct mail advertising messages often
CANES Contracting Strategies for Full Deployment

DTIC Science & Technology

2012-01-01

9 CANES Program Functions in Full Deployment...contractors will design CANES, identifying specific hardware and developing the integration software necessary to consolidate existing C4I functions . At...would be responsible for execut- ing the purchased design and assembling the systems, ensuring that the integration software is functioning . An
US Army Proposed Automatic Test Equipment Software Development and Support Facility.

DTIC Science & Technology

1982-10-29

programs would be prepared as weapon and prime system operating software. The ATE Software Development and Support Facility will help prevent the TPS...ONE AS A STANDARD **Partially being Developed (2) UNDER DEVELOP- by Navy CSS Prgram MENT (3) NEEDS TAILOR- (5) NEEDS ING FOR ARMY DEVELOPMENT A- 2
Strategies for Resolving the Cyber Attribution Challenge

DTIC Science & Technology

2013-05-01

grant- ing the United States extraterritoriality in the prosecution of US citizens engaged in child sex tourism .10 Furthermore, section 40 7202 of the...the Internet Gover - nance Forum. The United States has been active in venues such as the Organization for Economic Cooperation and Devel- opment in
Investigation of Coating Compounds and Adhesives for Self-Supporting Collapsible Fuel Storage Tanks.

DTIC Science & Technology

1977-06-01

guideline value of 25 lbs/ in. These low values were obtained because the prima ry mode of failure was between coats of the polyether coat- ing compound...method was developed for spray coating fabric substrates wi th one-shot pol yurethane materia ls yielding a coated fabric. Microscopic examination
Psychological and Physiological Effects of Wearing a Gas Mask or Protective Suit Under Non Exercising Conditions

DTIC Science & Technology

1988-02-02

heat conditions. A number of studies have found decreased exercise endurance while wear- ing a mask (Van Huss, Hartman, Craig and Steinhaus , 1967... Steinhaus , A.H. (1967) Respir- atory burden of the field protective mask under exercise load (Abstract). Federation Proceedings 26:721. 28 Vittorio, P.V. and
Task Inventory Construction

DTIC Science & Technology

1976-06-01

clay coo candy chance clean(er) cook(ed) cane change clear cook(ing) cannon chap clerk cooky (ie)(s) cannot charge clever cool(er) canoe charm...deck donkey deed don’t deep door deer doorbell defeat doorknob defend doorstep defense dope delight dot den double dough dove down
Toxicologic Evaluation of Trichloroacetic Acid: Effects on Rat Liver Peroxisomes and Enzyme Altered Foci.

DTIC Science & Technology

1986-05-01

studies with the hypolipid- emic agent gemfibrozil . J Natl Cancer Inst. 67:1105- 1120 (1981). 88. De La Iglesia, F.A., Pinns, S.M., Luca, J., and McGuire...E.J. Quantitative sterology of peroxisomes in hepatocytes from hyperlipoproteinemic patients receiv- ing gemfibrozil . Micron. 12:97-98 (1981). 89
A Model Counting Characterization of Diagnoses

DTIC Science & Technology

2002-05-04

Hamscher et al., 1992] Hamscher W., Console L., and de [ Shanahan , 1993] Shanahan M. Explanation in the Situa- Kleer J. Readings in Model-Based Diagnosis...1998] Kohlas J., Anrig B., Haenni R., and ing: Diagnosis and Learning, Southampton, 1988. Monney P. A. Model-Based Diagnosis and Probabilistic [Struss

Project SQUID. A Program of Fundamental Research on Liquid Rocket and Pulse Jet Propulsion

DTIC Science & Technology

1947-01-01

However, while the acoustical case can very well be represented by a correspond- ing linear electrical system, no way lias been found to represent...a carbon tube containing the gas to be decomposed thermally will be heated and its tem- perature determined by an optical pyrometer ; by the ojier
Research at USAFA 2012

DTIC Science & Technology

2012-02-01

doubt!” from the fermentative aspect (ethanol) and hold great promise for produc- ing large yields of biomass available for creating renewable...Peregrine’s 20-cm diameter mem- brane telescope into a volume the size of an individual serving of yogurt ! Latch’s research has been very successful
Attraction of Mosquitoes to Diethyl Methylbenzamide and Ethyl Hexanediol

DTIC Science & Technology

1990-09-01

tant to the biting midges Culicoides pulicaris that 8% ethyl acetate was attractant to the Linn. and Culicoides puncticoUis Becker (Cera- vinegar fly...Drosoph- finding by mosquitoes (Diptera: Culcidae): a review. ila melanogaster Meigen to the products of ferment - Bull. Entomol. Res. 70:525-532. ing banana
Response Acquisition under Targeted Percentile Schedules: A continuing Quandary for Molar Models of Operant Behavior

DTIC Science & Technology

1993-07-01

dimensions topics such as timing (e.g., Gibbon & Allan, from interresponse-time duration (e.g.. Alle- 1984), numerositv (e.g., Gallistel , 1989), and...Behavior, 51, 145-162. Snapper, A. G., & Inglis, G. B. (1985). SKED-li soft- Gallistel , C. R. (1989). Animal cognition: The repre- ware system. Kalamazoo
Investigations Regarding Anesthesia during Hypovolemic Conditions.

DTIC Science & Technology

1983-09-25

Wilson N, Ngsee J, Turnbull KW, Leighton K: Haemodynamics and plasma vasopressin responses with high-dose fentanyl anaesthesia dur- ing aorto-coronary...on the binding of CO2 to human haemoglobin and , . . 5. Christiansen J, Douglas CG, and Haldane on CO2 transport in the circulating blood. JS: The
Antibodies to Liposomal Phosphatidylcholine and Phosphatidylsulfocholine

DTIC Science & Technology

1990-01-01

689: 319-326. ing mice with bromelain -treated mouse erythrocytes (Cox BiSSERET, P., ITO, S., TREMBLAY, P.-A., VOLCANI, B.E., and Hardy 1985), and...Cox, K.O., and HARDY, S.J. 1985. Autoantibodies against mouse and cross-reacted with lysolecithin and sphingomyelin, thus bromelain -modified RBC are
Development of Antidepressants as Novel Agents To Treat Small Cell Lung Cancer

DTIC Science & Technology

2014-08-01

least in part by the capacity of these drugs to disrupt autocrine survival loops between neuro - transmitters and their receptors at the surface of SCLC...Ser10 (p-H3; Millipore), cleaved caspase-3 (CC3; Cell Signal- ing Technology), insulin (DAKO), and synaptophysin (SYN; Neuro - mics). Alexa Fluor
Natural Language Video Description using Deep Recurrent Neural Networks

DTIC Science & Technology

2015-11-23

records who says what, but lacks tim- ing information. Movie scripts typically include names of all characters and most movies loosely follow the...and Jürgen Schmidhuber. A novel approach to on-line handwriting recognition based on bidirectional long short-term memory networks. In Proc. 9th Int
Author Detection on a Mobile Phone

DTIC Science & Technology

2011-03-01

handwriting , and to mine sales data for profitable trends. Two broad categories of machine learning are supervised learn- ing and unsupervised learning...evaluation,” AI 2006: Advances in Artificial Intelligence, p. 1015–1021, 2006. [23] “Gartner says worldwide mobile phone sales grew 17 per cent in first
Installation Restoration Program, Phase II - Confirmation/Quantification Stage 1 for Travis Air Force Base, California

DTIC Science & Technology

1986-04-07

Commissary/ FCS Operating Loc L Hq MAC U.S. Customs U.S. Department of Agriculture U.S. Postal Service USAF Trial Judiciary 5th Circuit 17th...extinguish- ing agents used at the site were aqueous film forming foam ( AFFF ), protein foam, and water. The site has no berms or diKes to contain...in ^r^u-i —-••^■■r*M(^*iMr<-* ■•»«M<N»--*’ fc «^’^a • M oo ooo ostfr^o^oo — — or* — — i-*’«’*-«’^r^o — M -N*^ or»^ -iM^0’^w^’-><n^>#^’fN
["... mein Recht muss mir werden!" Hermann Bahr's tragicomedy Der Querulant (1914)].

PubMed

Gaderer, Rupert

2014-12-01

At the end of the eighteenth century, people who became notorious for their excessive engagement in legal proceedings started being labeled as "querulents" or "paranoid litigants". The term "querulents" first appeared in the General Order of the Court for the Prussian States (Allgemeine Gerichtsardnung für die Preussischen Staaten) from July 6, 1793. From there on, the spectrum of juridical measures undertaken against the so-labeled litigators included classifying these persons as ineligible for legal action and psychiatric hospitalization. The paper discusses to what extent Hermann Bahr rearranges psychiatric and legal knowledge about this special type of the complainer in his tragi- comedy Der Querulant, premiered in 1914. This concerns, first, the theatricality of the body and speech, secondly, the use of cultural techniques of writing and, thirdly, conflict- ing notions of justice. Therefore, the paper analyzes the aesthetic function of querulous behavior in the dramatic structure of the play from the point of view of both media theory and literary theory.
Beam Test Studies of 3D Pixel Sensors Irradiated Non-Uniformly for the ATLAS Forward Physics Detector

DTIC Science & Technology

2013-02-21

telescope consists of six Mimosa tracking planes, the readout data acquisition system and the trigger hardware, and provides a ≈ 3µm track point- ing...is larger than the Mimosa sensors of the telescope, separate sets of data were taken to cover the irradiated and non-irradiated regions of the sensors
Multi-Target Tracking for Swarm vs. Swarm UAV Systems

DTIC Science & Technology

2012-09-01

Uhlmann, “Using covariance intersection for SLAM,” Robotics and Autonomous Systems, vol. 55, pp. 3–20, Jan. 2007. [10] R. B. G. Wolfgang Niehsen... Krause , J. Leskovec, and C. Guestrin, “Data association for topic intensity track- ing,” Proceedings of the 23rd international conference on Machine
Forestry herbicide influences on biodiversity and wildlife habitat in southern forests

Treesearch

Karl V. Miller; James H. Miller

2004-01-01

In the southern United States, herbicide use continues to increase for timber management in commercial pine (Pinus spp.) plantations, for mod@ing wildlife habitats, and for invasive plant control. Several studies have reported that single applications of forestry herbicides at stand initiation have minor and temporary impacts on plant communities and...
78 FR 72064 - Request for Comments on Methods for Studying the Diversity of Patent Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

...] Request for Comments on Methods for Studying the Diversity of Patent Applicants AGENCY: United States... . SUPPLEMENTARY INFORMATION: Section 29 of the AIA charged the Director of the USPTO with ``establish[ing] methods... submit comments on any related issues that they believe are relevant. (1) How and by which methods should...
Gleaning Structure from Sound: The Role of Prosodic Contrast in Learning Non-Adjacent Dependencies

ERIC Educational Resources Information Center

Grama, Ileana C.; Kerkhoff, Annemarie; Wijnen, Frank

2016-01-01

The ability to detect non-adjacent dependencies (i.e. between "a" and "b" in "aXb") in spoken input may support the acquisition of morpho-syntactic dependencies (e.g. "The princess 'is' kiss'ing' the frog"). Functional morphemes in morpho-syntactic dependencies are often marked by perceptual cues that render…
Project 1721: A U.S. Army War College Assessment on Russian Strategy in Eastern Europe and Recommendations on how to Leverage Landpower to Maintain the Peace

DTIC Science & Technology

2017-03-01

daunt- ing security challenges facing the United States and the North Atlantic Treaty Organization (NATO). Project 1721 would not be possible without...America’s Commitment to the North Atlantic Treaty Organization (NATO) Alliance..................................................xix Russia’s...43 Chapter 5: The North Atlantic Treaty Organization (NATO) and the New Russian Strategic Environment
Binary Classification of an Unknown Object through Atmospheric Turbulence Using a Polarimetric Blind-Deconvolution Algorithm Augmented with Adaptive Degree of Linear Polarization Priors

DTIC Science & Technology

2012-03-01

geometry of reflection from a smooth (or mirror-like) surface [27]. In passive polarimetry , the angle of polarization (AoP) provides information about... polarimetry for remote sens- ing applications”. Appl. Opt., 45(22):5453–5469, Aug 2006. URL http://ao.osa.org/abstract.cfm?URI=ao-45-22-5453. 27
Environmental and Water Quality Operational Studies. Water Quality, Macroinvertebrates, Larval Fishes, and Fishes of the Lower Mississippi River - A Synthesis.

DTIC Science & Technology

1986-09-01

ing in the abandoned channels and seldom being encountered elsewhere. These fishes include the spotted gar, bowfin ( Amia calva ), black bull- head...two individuals of the bowfin ( Amia calva ) were collected in the 1979-1980 study, one by electroshocking in April 1979 at a re- vetted bank and one in a
The Transatlantic Bargain

DTIC Science & Technology

2012-01-01

Transatlantic Bargain from Truman to Obama, New York, The Continuum International Publish- ing Group Inc ., 2010. 44 the late 1940s were striving for or... Nike -Hercules surface-to-air missiles. 51 is most vividly remembered for its campaign to move NATO away from what Washington perceived at the time to

Conditional Inference and Advanced Mathematical Study: Further Evidence

ERIC Educational Resources Information Center

Inglis, Matthew; Simpson, Adrian

2009-01-01

In this paper, we examine the support given for the "theory of formal discipline" by Inglis and Simpson (Educational Studies Mathematics 67:187-204, "2008"). This theory, which is widely accepted by mathematicians and curriculum bodies, suggests that the study of advanced mathematics develops general thinking skills and, in particular, conditional…
NAVO MSRC Navigator. Spring 2001

DTIC Science & Technology

2001-01-01

preparations for UGC 2001 are almost complete. This year’s conference promises to be a good one, afford- ing us the opportunity to extend some Gulf Coast...cur- rent market pricing, and other rea- sonable estimates would not signifi- cantly alter the predicted trends. The performance model1 estimates CPU
The Secret Driving Force Behind Mongolia’s Successful Democracy

DTIC Science & Technology

2016-03-01

and media representatives from Myanmar dur- ing a recent visit to Mongolia, I was asked many questions regarding issues that we take for granted. As...the head of the Mongolian- Myanmar parliamentary group, I extended my best wishes to the Myanmar people’s effort to reform their country into a
Irrigated agriculture and freshwater wetlands: A struggle for coexistence in the western United States

Treesearch

A. Dennis Lemly

1994-01-01

This paper is a review of the major environmental problems associated with irrigated agriculture in the western United States. Freshwater wetlands are being contaminated by subsurface agricultural irrigation drainage in many locations. Historic freshwater inflows have been diverted for agricultural use, and remain- ing freshwater supplies are not sufficient to maintain...
Army Sustainability and Leadership in Energy and Environmental Design

DTIC Science & Technology

2010-08-01

penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE AUG 2010 2...strategies that DOD and the Army have implemented are policies such as buy-ing green products for cleaning and promoting tele- work or telecommuting
Recent Trends in General Education Design, Learning Outcomes, and Teaching Approaches. Key Findings from a Survey among Administrators at AAC&U Member Institutions

ERIC Educational Resources Information Center

Association of American Colleges and Universities, 2016

2016-01-01

This report summarizes key findings from a national survey among chief academic officers at Association of American Colleges and Universities (AAC&U) member institutions and explores how institutions are defining common learning outcomes, trends related to general education design and the use of emerging, evidence-based teaching and learning…
75 FR 61653 - Advance Notice of Proposed Rulemaking Regarding Authority To Require Supervision and Regulation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... of ``(A) * * * identify[ing] risk to the financial stability of the United States that could arise... of reliance on short-term funding; and (K) Any other risk-related factors that the Council deems..., size, and scale of nonbank financial companies? a. Should a risk-adjusted measure of a company's assets...
Visual Information Processing and Response Time in Traffic-Signal Cognition

DTIC Science & Technology

1992-03-01

TYPE AND DATES COVERED IMarch 1992 IMaster’s Thesis 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS VISUAL INEORMATION PIRXC ING AND RESPOSE TIME IN TRAFFIC...34The Influence of the Time Duration of Yellow Traffic Signals On Driver Response," ITE Journal, (November 1980). 145 William D. Kosnic. " Self
BRCA1 and BRCA2 Mutations

MedlinePlus

... tested for this mutation. Should You Be Tested? Genetic testing is only recommended for people with a high risk of having a BRCA mutation. To help determine if you should have test- ing, some of the questions your ob-gyn or other health care profes- sional may ask you include the ...
Basic Grammar in Use: Reference and Practice for Students of English.

ERIC Educational Resources Information Center

Murphy, Raymond

This basic grammar book for beginning to low-intermediate level students of English contains 106 units. The units are divided into the following categories: Present; Past; Present Perfect; Passive; Future and Modals; Imperative; "There" and "It"; Verb Forms; Auxiliary Verbs; Negatives; Questions; "To" and "-ing"; Reported Speech; "Get" and "Go";…
Base Reutilization Status: An Assessment

DTIC Science & Technology

2000-03-01

substantially as office build- ings and retail buildings are constructed. No data are available on payrolls for the new jobs . However, earnings are likely to...date is 30.3 The average earnings from the new jobs are above the state average. The average earnings from the existing number of biotechnology
10. Freiburger Symposium 2011 der SCG-Division Industrielle Chemie Technology Progress, Success Key for our Production Sites.

PubMed

Naef, Olivier

2012-01-01

This short paper presents the abstracts of the different presentations during 10. Freiburger Symposium 2011 der SCG-Division Industrielle Chemie: Technology Progress, Success key for our production sites held Thursday and Friday, September 29 and 30, 2011 at the Ecole d'ingénieurs et d'architectes de Fribourg (Switzerland).
40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in....g., carbon adsorption system or condenser) or other control device that is designed and operated to... compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon adsorption...
40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in....g., carbon adsorption system or condenser) or other control device that is designed and operated to... compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon adsorption...
40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in....g., carbon adsorption system or condenser) or other control device that is designed and operated to... compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon adsorption...
Systemic Review and Meta-analysis of Randomized Clinical Trials Comparing Primary vs Delayed Primary Skin Closure in Contaminated and Dirty Abdominal Incisions

DTIC Science & Technology

2013-06-26

Chatwiriyacharoen14 Betadine gauze Unclear 5 Unclear Until suitable for suture Purulent dis- charge or mate- rial or surround- ing cellulitis Unclear Reopened and...Opened McGreal et al20 Povidone-io- dine (1%)- soaked wick Subcuticu- lar suture 4 Unclear Steri-Strips on day 4 Cellulitis , cul- ture-positive
Beyond Programs: Asserting Our Authority as Teachers

ERIC Educational Resources Information Center

Wilhelm, Jeffrey D., Ed.

2007-01-01

Reflection and revision are the result of knowledge, experience, and the willingness to risk; they are essential, says Wilhelm, to "play[ing] out the big possibilities" in "something as complex and intensely human as teaching." Even as a contributor to the national standards project, various literature anthologies, and reading and composition…
HomeFront Strong (HFS): Building Resiliency in Military Families

DTIC Science & Technology

2015-09-01

spouses. Contemporary Family Therapy , 37(3), 221-231. doi: 10.1007/s10591-015-9336-8. Presentations Kees, M. (2014). Promoting resilience in...diffe rent tastes on different parts of your tongue • Try tast ing things w ith strong flavors (e.g. sour lemon. bitter dark chocolate . salty pretzels
Unprovable Security of Two-Message Zero Knowledge

DTIC Science & Technology

2012-12-19

functions on NP-hardness. In STOC ’06, pages 701–710, 2006. 10 [BCC88] Gilles Brassard, David Chaum , and Claude Crépeau. Minimum disclosure proofs...security of several primitives (e.g., Schnorr’s identification scheme, commitment schemes secure under weak notions of selective open- ing, Chaum blind
Physics of Particle Entrainment Under the Influence of an Impinging Jet

DTIC Science & Technology

2008-12-01

Approved for public release; distribution unlimited 1 PHYSICS OF PARTICLE ENTRAINMENT UNDER THE INFLUENCE OF AN IMPINGING JET Robert Haehnel...Ing. Wesen. Heft 361). Phares, D.J., Smedley , G.T. and Flagan, R.C. (2000) "The wall shear stress produced by the normal impingement of a jet on a

FOA Information from the Research Institute of Swedish National Defence on Electronic Warfare (FOA Orientar om Electronic Warfare),

DTIC Science & Technology

1967-01-01

probablity ot penetring to target in the preaence of atr do- fance . Curve P, =probebility of destro),ing target in the presence of air defence. Weapon...so rendering the lions. At high frequencies ( gen - quency range and sector of ter- traffic less sensitive to jamming. erally those tsed on radio links
Strategic Studies Quarterly. Volume 4, Number, Summer 2010

DTIC Science & Technology

2010-01-01

html. 68. Francis Fukuyama, "’Stateness’ First," Journal of Democracy 16, no. 1 (2005): 88. 69. Dobbins et al., Beginners Guide to Nation-Building, 255...USCENTCOM, "Operation Desert Shield/Desert Storm," 6. For a flowchart explain- ing these relationships, see Khaled bin Sultan, Desert Warrior (New
Processing Trade-Offs in the Reading of Dutch Derived Words

ERIC Educational Resources Information Center

Kuperman, Victor; Bertram, Raymond; Baayen, R. Harald

2010-01-01

This eye-tracking study explores visual recognition of Dutch suffixed words (e.g., "plaats+ing" "placing") embedded in sentential contexts, and provides new evidence on the interplay between storage and computation in morphological processing. We show that suffix length crucially moderates the use of morphological properties. In words with shorter…
Infectious Disease and National Security: Strategic Information Needs

DTIC Science & Technology

2006-01-01

reemerging diseases once thought to be in decline. The world now faces the threat of a human influenza pandemic aris- ing from the recently emerged...Surveillance, Including Early Warning . . . . . . . . . . . . . . . . . . . . . . . 44 Sources Include Information on Diseases in Humans , Animals, and...Sources Addressing Human , Animal, and Plant Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 5.5. Information
Social Development in Individuals with High Functioning Autism and Asperger Disorder

ERIC Educational Resources Information Center

Koegel, Robert L.

2007-01-01

Until recently, and even in many current research circles, social behavior in individuals with autism spectrum disorders (including those with high functioning autism or Asperger disorder) was considered to be unmodifiable. Mundy, Henderson, Inge, and Coman and McGee and Daly shed new light on this concept of intractability, suggesting that…
Moderating the Debate: Rationality and the Promise of American Education

ERIC Educational Resources Information Center

Feuer, Michael J.

2006-01-01

This eloquent book examines the complex--and often problematic--relations between education research, policy, and practice, and proposes ways to improve those relationships in the interest of meaningful education reform. Based on the Burton and Inglis Lectures, which Michael Feuer delivered at the Harvard Graduate School of Education in 2004 and…
Archaeological Survey of the Proposed Johnston Trails Project in the Downstream Corridor, Saylorville Lake, Polk County, Iowa. Phase 1

DTIC Science & Technology

1993-01-01

located in the region. The Des Moines River and its immediate tributaries deeply incise the till plain, expos- ing the underlying bedrock in many...and Leah D. Rogers 1985 Interlertive Overview of Cultura Resouwves in Say/orvil/e Lake, Iowa, VoL I. Project CAR-627, Cen- ter for Archaeological
Development of Improved High Strength Alumiunum Powder Metallurgy Products

DTIC Science & Technology

1978-12-31

responsible for the reduction in strenqIth. The initiation of microplasticity occurs between 7 305 and 312 MPa for the I/M products and between 215 and 255...evidence that microplasticity P.nd strain harden- ing-is occurring in the PFZ. The strengthening mechanism in the artificially aged extrusion products is
The Mechanism of the Crystallizing Action of Solids on the Supercooled Water Aerosols,

DTIC Science & Technology

1977-12-30

energetic mixing into it unavoidabl y fall the air bubbles, wh ich, floating , they carry alo ~g with themselves the droplets of water, causing their...reagents. For tes t ing of last/latter position, we were conduc ted se vera l preliminary experiments. In the first of them , was hydrophiliz ed
JPRS Report, Soviet Union: International Affairs.

DTIC Science & Technology

1988-07-05

Algerian Cinema is Fighting (T.S. Tsarapkina. The Cinema of Algeria. Iskusstvo Publish- ing House, 1986) 9 63 Glukhov S. The Countries of the Persian...DISCUSSION Colonialism under Fire 44 CULTURE, LITERATURE, ART L. Cherkasskiy. China. "Hazy" Poetry 46 N. Chukina. Made by the Hands of Malaysians 48
40 CFR Appendix D to Part 403 - Selected Industrial Subcategories Considered Dilute for Purposes of the Combined Wastestream Formula

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Selected Industrial Subcategories Considered Dilute for Purposes of the Combined Wastestream Formula D Appendix D to Part 403 Protection of...-MENT REGULATIONS FOR EXIST-ING AND NEW SOURCES OF POLLUTION Pt. 403, App. D Appendix D to Part 403...
In Vitro bile acid binding of kale, mustard greens, broccoli, cabbage and green bell pepper improves with microwave cooking

USDA-ARS?s Scientific Manuscript database

Bile acid binding potential of foods and food fractions has been related to lowering the risk of heart disease and that of cancer. Sautéing or steam cooking has been observed to significantly improve bile acid binding of green/leafy vegetables. It was hypothesized that microwave cooking could impr...
Interactions of Airfoils with Gusts and Concentrated Vortices in Unsteady Transonic Flow,

DTIC Science & Technology

1983-01-01

ain(U, u, ) bances into the solution domain. One such smooth- ,ui ,j ing method was recently demonstrated by Murman and Stremel ,10 who distributed...were qualitatively similar to the predic- °Murman, E. M. and Stremel , P. M., "A Vortex tions of linear theory, but important quantitative Wake
40 CFR 403.5 - National pretreatment standards: Prohibited discharges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND NEW... designed to prevent Pass Through and/or Interference, as the case may be, was developed in accordance with... Through or Interference; or (B) If a local limit designed to prevent Pass Through and/or Interference, as...
COX-2 and Prostate Cancer Angiogenesis

DTIC Science & Technology

2002-03-01

papilloma virus -18 ing cell nuclear antigen staining), but induced ap- immortalization of PIN cell areas of radical-pros- optosis (TdT-mediated dUTP...the COX-2 surrounding basal cells (75%).3cA human PIN cell inhibitor had no effect on proliferation (proliferat- line was established by human
Answer Mining from On-Line Documents

DTIC Science & Technology

2001-01-01

successions occurred at IBM in 1999? In addition, questions may also ask about de- velopments of events or trends that are usually answered by a text ... summary . Since data produc- ing these summaries can be sourced in different documents, summary fusion techniques as pro- posed in (Radev and McKeown
Strategic Planning: Shaping Future Success

DTIC Science & Technology

2016-09-01

fielding, the PM may also be planning for future increments , sustainment and other long-term ef- forts. Strategic planning can help the PM position these...introduced the Planning, Programming, and Budgeting System (PPBS) to the DoD. Prior to that, the DoD’s budget - ing focused on areas such as overhead
Contribution to the Doctrine Governing Hospitalization in Nationwide Defensive Warfare (1). Wartime Military Medical Equipment for Care of the Sick (2). Present-Day Trends in the Development of Chemical Weapons (3). Pharmacological and Toxicological Properties of Present-Day Combat Poisons Which Cause Malaise (CS, CR)

DTIC Science & Technology

1975-10-31

which con ribute to optinalmi uti .1 zation of capacity and to ra:L• ing the "L evel of utilization" of c.npacity, such as the maneuverabil- ity of Che...THE SICK Medical Colonel Aleksander lhranilovic, docent and graduate pharmacist , and Medical Colonel Ivan Palmar, docent and doctor The process of
Doctor, It Hurts When I Do This

DTIC Science & Technology

2009-10-01

procedures is 520 pages. For comparison, Moby Dick is a minnow-sized 420 pages and even Tolstoy’s epic War and Peace is dwarfed at 699 pages. As the... advertised to be. The ongoing events in the financial world offer an interest- ing case in point. The global financial system has become highly
Granite Springs Valley, Nevada - Well data and Temperature Survey

DOE Data Explorer

Faulds, Jim

2017-09-14

This data is associated with the Nevada Play Fairway project and includes excel files containing raw 2-meter temperature data and corrections. GIS shapefiles and layer files contain ing location and attribute information for the data are included. Well data includes both deep and shallow TG holes, GIS shapefiles and layer files.

Time to Terminate Toilet Papering

ERIC Educational Resources Information Center

Moscinski, David

2008-01-01

Each September in Wisconsin students return to school, football games draw enthusiastic crowds, and homecoming week is celebrated. Trees lose their leaves only to be re-adorned in white in that generation bridging tradition known as toilet papering. Community residents have differing opinions on "tp"ing, in large part determined by whether they…
Increased Use of Productivity Management Can Help Control Government Costs.

DTIC Science & Technology

1983-11-10

estimated that 34 percent of agency spend- ing reductions made to balance the budget in fiscal year 1984 can be attributed to the productivity program. The...result in the services 5. [] use of employee incentives (9) of some employees no longer being required in the unit in which they 6. [) quality of worklife
VHF Electrical Properties of Frozen Ground Near Point Barrow, Alaska,

DTIC Science & Technology

1981-06-01

depth. When temperature is depressed even further, the freez - 3. RFI does not require the ground to be disturbed ing of any remaining adsorbed water will...sky wave Seattle, Washington, at 18.6 kHz. Both instruments propagating from a distant or local transmitter to use a small ferrite -loaded coil to
AID and Universities Have Yet to Forge an Effective Partnership to Combat World Food Problems.

DTIC Science & Technology

1981-10-16

1979, and (3) beans and cowpeas started in October 1980. These 3 CRSPs involve 30 title XII universities and institutions. Each CRSP 27 activity is...establish firm links with develop- ing countries. An official from the beans and cowpeas CRSP said that CRSP is not incorporated as part of AID host-country
Boundary Kernel Estimation of the Two Sample Comparison Density Function

DTIC Science & Technology

1989-05-01

not for the understand- ing, love, and steadfast support of my wife, Catheryn . She supported my move to statistics a mere fortnight after we were...school one learns things of a narrow and technical nature; 0 Catheryn has shown me much of what is fundamentally true and important in this world. To her
Acquisition of English Grammatical Morphology by Native Mandarin-Speaking Children and Adolescents: Age-Related Differences

ERIC Educational Resources Information Center

Jia, Gisela; Fuse, Akiko

2007-01-01

Purpose: This 5-year longitudinal study investigated the acquisition of 6 English grammatical morphemes (i.e., regular and irregular past tense, 3rd person singular, progressive aspect-"ing", copula BE, and auxiliary DO) by 10 native Mandarin-speaking children and adolescents in the United States (arrived in the United States between 5…
Korean Affairs Report No. 282

DTIC Science & Technology

1983-05-17

Seoul denied the poach - ing charges against its ship and said the ship would soon be released. The Korean Government has decided to order any Korean...He served in France, the Republic of the Ivory Coast, the Republic of Tunisia and Morocco before he was sent to Cameroon in 1982. The government
Testing a Wheeled Landing Gear System for the TH-57 Helicopter

DTIC Science & Technology

1992-12-01

initial comparison was done using a structural analysis program, GIFTS , to simultaneously analyze an~i compare the gear systems. Experimental data was used...15 B. GIFTS PROGRAM RESULTS ............................ 15 1. Model...Element Total System ( GIFTS ) structural analysis program, which is resident oin the Aeiunauimia Euginme1ing Department computer system, an analysis
Controller Requirements for Uncoupled Aircraft Motion. Volume 1

DTIC Science & Technology

1984-09-01

the nose down to the run-in line, followed by roll- out into a straight line dive. Well learned precognitive maneuvers do not nvolve much psychomotor...This is initially a precognitive transient track- ing maneuver, fo’llowed by maintaining a constant, safe g level until a desired ra e of climb- is
Translations on USSR Science and Technology, Biomedical and Behavioral Sciences, Number 41

DTIC Science & Technology

1978-08-07

virus infection was detected more often dur- ing an aggravation of chronic bronchitis and in patients with frequent pneu- monias in anamnesis . We also...laboratory examination hepatitis in anamnesis was detected in k (3.03/0 donors and in 13 (8.02$) members of their families. Spleno- megaly was noted in 7
JPRS Report, Soviet Union, Foreign Military Review, No. 6, June 1988

DTIC Science & Technology

1988-12-08

conditions. This is achieved above all by rais - ing the mobility of rear services, which must be the very same as for the supported troop formations...surface-to-air mis- sile regiments (Soest and Oldenburg ), 33d and 34th electronic support regiments (Goch and Schleswig), all from the 4th Air Defense
Deconstructing Delphinium: Violence and Flowers in Rousseau's "Emile" and Henke's "Chrysanthemum"

ERIC Educational Resources Information Center

Kinard, Timothy

2012-01-01

This article is an attempt to contribute to the conversation about "go[ing] beyond all kinds of binary thinking" (Lenz Taguchi, "Going beyond the theory/practice divide in early childhood education: introducing an intra-active pedagogy," 2010, p. 50), especially the binary which positions "adults" and "children" as being powerful and powerless,…
Uncertainty Quantification using Epi-Splines and Soft Information

DTIC Science & Technology

2012-06-01

use of the Kullback - Leibler divergence measure. The Kullback - Leibler ...to illustrate the application of soft information related to the Kullback - Leibler (KL) divergence discussed in Chapter 2. The idea behind apply- ing... information for the estimation of system performance density functions in order to quantify uncertainty. We conduct empirical testing of
Strategic Studies Quarterly. Volume 4, Number 2, Summer 2010

DTIC Science & Technology

2010-01-01

Fukuyama, “‘Stateness’ First,” Journal of Democracy 16, no. 1 (2005): 88. 69. Dobbins et al., Beginners Guide to Nation-Building, 255–59. 70. Ibid...USCENTCOM, “Operation Desert Shield/Desert Storm,” 6. For a flowchart explain ing these relationships, see Khaled bin Sultan, Desert Warrior (New York
Different Types of Internet Use, Depression, and Social Anxiety: The Role of Perceived Friendship Quality

ERIC Educational Resources Information Center

Selfhout, Maarten H. W.; Branje, Susan J. T.; Delsing, M.; ter Bogt, Tom F. M.; Meeus, Wim H. J.

2009-01-01

The current study examined the longitudinal associations of time spent on Internet activities for communication purposes (i.e., IM-ing) versus time spent on Internet activities for non-communication purposes (i.e., surfing) with depression and social anxiety, as well as the moderating role of perceived friendship quality in these associations.…
All Electric Combat Vehicles (AECV) for Future Applications

DTIC Science & Technology

2004-07-01

includes the very high-speed travels. The Super Speed Maglev System (GE Trans-rapid RTO-TR-AVT-047 8 - 3 STANDARDIZATION AND DUAL USE International GmbH...Germany). [25] Super Speed Maglev System: Dipl Ing Gerhard Wahl (WEC, 19-21 June 2000). [26] Development of Dual Use Technologies and a Strategy for
Characterization of the Contribution of Ceramide to Chemotherapy Sensitization in Breast Cancer Cells

DTIC Science & Technology

2002-09-01

abbreviations used are: P-gp, P-glycoprotein; MDR, multidrug re- Association of New York, Shoes on Sale/QVC. sistance; FB1 , fumonisin B1; SPT, serine...when Fumonisin B1, a ceramide synthase inhibitor, was ing on the integrity of their schedule-oriented cell cycle checkpoints; G2/M arrest added to
Computer-Mediated Training Tools to Enhance Joint Task Force Cognitive Leadership Skills

DTIC Science & Technology

2007-04-01

University); and 5d. TASK NUMBER Barclay Lewis (American Systems) 5e. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ...ple G am ing Platform D ecisive A ction for Training ..................................................... 43 6. Perform ance M etrics...Figure 15: Automated Performance Measurement System ................................................................... 48 iv COMPUTER-MEDIATED TRAINING
Ocean Engineering Studies Compiled 1991. Volume 10. External Pressure Housing - Concrete

DTIC Science & Technology

1991-01-01

Hafsklold Ing. F. Selmer AS Anton Brandtzaeg Post Office Box 256 Professor of Construction & Harbour Oslo, Norway Engineering Norwegian Technical University...1984, pp 364-411. 50. 0. Olsen , "Implosion analysis of concrete cylinders under hydro- static pressure," ACI, vol 75, no. 3, Mar 1973, pp 82-85. 51. K.P
Reconceptualizing Play: Aesthetic Self-Definitions

ERIC Educational Resources Information Center

Guss, Faith

2005-01-01

This article aims to trouble the identity of children's dramatic play(ing). It contains two interweaving threads of discourse. In one thread lies a discussion of how children can trouble and extend their own identities through the aesthetic form-languages and conventions they employ and deploy in their dramatic playing/pretend playing. Whereas…

JPRS Report, East Asia Southeast Asia

DTIC Science & Technology

1987-06-11

tive and prosecution aspects as essential elements of the solution. "Preventive" would refer to reduc- ing red tape and too much discre- tion...Youth Union in Colleges 29 9332/9835 CSO: 4209/417 101 ,„«„««T„ VIETNAM CCONOMIC NGUYEN CO THACH ADMITS TO ECNOMIC MISTAKES Stockholm SVENSKA
Superior Volumetric Modulated Arc Therapy Planning Solution for Prostate Patients

DTIC Science & Technology

2013-04-01

co-workers from the University of Chicago for provid- ing them with the reconstruction from their data using their implementation of their ASD-POCS...1245 (2000). 8D. M. Shepard , M. A. Earl, X. A. Li, S. Naqvi, and C. Yu, “Direct aperture optimization: A turnkey solution for step-and-shoot IMRT
A Historical Perspective of the USAWC Class of 1940

DTIC Science & Technology

1987-04-15

speci- fic source material so as to avoid becom- ing submerged in statistical and other data and finding little or no time for thought and reflection...Other Sign. WWII Asg: - Misc: - Rank Attained by 󈧲: BC CPT Oscar R Johnston INF Source Commision: USMA Age: 42 Assign After AWC: Mbr . Sup and Proj
Missing Data as a Causal and Probabilistic Problem

DTIC Science & Technology

2015-07-01

for causal effects identification [18] seems promising. That is, use MID as a guide for constructing a “ zoo ” of structures where recoverability does...not seem to be possible, and then construct a general method for show- ing non-recoverability for this “ zoo .” Some results on non-recoverability do
Rarefaction Wave Eliminator Concepts For A Large Blast/Thermal Simulator.

DTIC Science & Technology

1985-02-01

hard copies of the pressure-time records. Final data process- ing was completed with the computer, printer , and plotter. Plots of pressure- time records...F ATTN: Prof 0. Zinke Fayetteville, AR 72701 Cdr, CRDC, AMCCOM ATTI: 4O-SPS-IL University of California PM=-J Lawrence Livermore Lab SOM-RSP-A ATTN
Functionality of ovalbumin during Chinese steamed bread-making processing.

PubMed

Sang, Shangyuan; Zhang, Huang; Xu, Lei; Chen, Yisheng; Xu, Xueming; Jin, Zhengyu; Yang, Na; Wu, Fengfeng; Li, Dandan

2018-07-01

Hen egg is commonly used in some cereal-based food, including cakes and bread. Ovalbumin, one of the major components of egg white protein, can affect the performance of the food product. The interaction between ovalbumin and gluten protein and its effect on property of dough and quality of Chinese steamed bread was investigated in this study. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) patterns indicated that ovalbumin was surprisingly not incorporated in glutenins by covalent bond, whereas size-exclusion high-performance liquid chromatography showed that glutenin macropolymer content in glutenins increased slightly. Furthermore, dynamic rheology experiments indicated ovalbumin led to a decrease inG' andG″ of dough. Based on molecular dynamic simulation and SDS-PAGE results, it was inferred that ovalbumin was not hydrolyzed by endopeptidases during dough fermentation and crosslinked to gluten proteins during steaming. Finally, ovalbumin improved maximum dough height (Hm) during dough development and specific volume of Chinese steamed bread. Copyright © 2018 Elsevier Ltd. All rights reserved.
Influence of fuel properties on internal nozzle flow development in a multi-hole diesel injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torelli, Roberto; Som, Sibendu; Pei, Yuanjiang

Fuel physical properties are known to influence in-nozzle flow behavior, in turn affecting spray formation in internal combustion engines. A series of 3D simulations was performed to model the internal nozzle flow in a five-hole mini-sac diesel injector. The goal of the study was to evaluate the behavior of two gasoline-like fuels (full-range naphtha and light naphtha) and compare them against n-Dodecane, selected from a palette used as a diesel surrogate. Simulations were carried out using a multi-phase flow representation based on the mixture model assumption with the Volume of Fluid (VOF) method, and including cavitation effects by means ofmore » the Homogeneous Relaxation Model (HRM). Validated methodologies from our previous studies were employed to account for full needle motion. Detailed simulations revealed the influence of the fuel properties on injector performance, injected fuel energy and propensity to cavitation. The three fuels were compared with respect to global parameters such as mass flow rate and area contraction coefficients, and local parameters such as pressure and velocity distribution inside the sac and orifices. Parametric investigations were also performed to understand the fuel response to changes in the fuel injection temperature, injection pressure, and geometry details. Cavitation magnitude was observed to be strongly associated with the values of saturation pressure. Owing to their higher volatility, the two gasoline-like fuels were observed to cavitate more than n-Dodecane across all the investigated conditions. While at full needle lift cavitation was reduced for all fuels, during the
Influence of fuel properties on internal nozzle flow development in a multi-hole diesel injector

DOE PAGES

Torelli, Roberto; Som, Sibendu; Pei, Yuanjiang; ...

2017-05-31

Fuel physical properties are known to influence in-nozzle flow behavior, in turn affecting spray formation in internal combustion engines. A series of 3D simulations was performed to model the internal nozzle flow in a five-hole mini-sac diesel injector. The goal of the study was to evaluate the behavior of two gasoline-like fuels (full-range naphtha and light naphtha) and compare them against n-Dodecane, selected from a palette used as a diesel surrogate. Simulations were carried out using a multi-phase flow representation based on the mixture model assumption with the Volume of Fluid (VOF) method, and including cavitation effects by means ofmore » the Homogeneous Relaxation Model (HRM). Validated methodologies from our previous studies were employed to account for full needle motion. Detailed simulations revealed the influence of the fuel properties on injector performance, injected fuel energy and propensity to cavitation. The three fuels were compared with respect to global parameters such as mass flow rate and area contraction coefficients, and local parameters such as pressure and velocity distribution inside the sac and orifices. Parametric investigations were also performed to understand the fuel response to changes in the fuel injection temperature, injection pressure, and geometry details. Cavitation magnitude was observed to be strongly associated with the values of saturation pressure. Owing to their higher volatility, the two gasoline-like fuels were observed to cavitate more than n-Dodecane across all the investigated conditions. While at full needle lift cavitation was reduced for all fuels, during the
Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats.

PubMed

Ahmed, Hanaa H; Khalil, Wagdy K B; Hamza, Amal H

2014-12-01

The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study. To achieve this target, the apoptotic/necrotic rate in hepatic cells was investigated morphologically by double staining with acridine orange/ethidium bromide to address the type of cell death induced by nano-Se in HCC-bearing rats. To predict the oxidative stress and DNA damage, the generation of 8-hydroxy-2-deoxyguanosine (8-OHdG) and 2-deoxyguanosine (2-dG) was examined. Moreover, the expression of some HCC-related genes was investigated such as aldo-keto reductase 1B10 (Akr1b10), ING3 and Foxp1 genes. As well as the histopathological study of liver tissue sections was performed. The results obtained from this study revealed that (HCC+Nano Se) group shows the highest number of damaged cancerous cells. Furthermore, the necrotic/apoptotic rate was significantly higher in (nano-Se+HCC), (HCC+Doxo) and (HCC+Doxo+nano-se) compared to that in the untreated HCC group. Treatment of HCC group with nano-se decreased the ratio of 8-OHdG/2-dG generation significantly with respect to the untreated HCC group. The opposite was observed regarding the gene expression of AKr1b10 and ING3. The treatment of HCC group with nano-se elicited significant increase in the expression of Akr1b10 and ING3 genes compared with untreated HCC group. On the other hand, the expression of Foxp1 gene was significantly decreased in HCC group treated with nano-se in comparison with the untreated HCC group. The histopathological study provided a supportive evidence for the molecular genetics study. Our data shed light on the molecular mechanisms of nano-se in attenuating HCC in the experimental model.
Project 5322 Mid-Term Report: Key Eco-Hydrological Parameters Retrieval And Land Data Assimilation System Development In A Typical Inland River Basin Of Chinas Arid Region

NASA Astrophysics Data System (ADS)

Faivre, R.; Colin, J.; Menenti, M.; Lindenbergh, R.; Van Den Bergh, L.; Yu, H.; Jia, L.; Xin, L.

2010-10-01

Improving the understanding and the monitoring of high elevation regions hydrology is of major relevance from both societal and environmental points of view for many Asian countries, in particular in terms of flood and drought, but also in terms of food security in a chang- ing environment. Satellite and airborne remote sensing technologies are of utmost for such a challenge. Exist- ing imaging spectro-radiometers, radars, microwave ra- diometers and backscatter LIDAR provide a very com- prehensive suite of measurements over a wide rage of wavelengths, time frequencies and spatial resolu- tions. It is however needed to devise new algorithms to convert these radiometric measurements into useful eco-hydrological quantitative parameters for hydrologi- cal modeling and water management. The DRAGON II project entitled Key Eco-Hydrological Parameters Re- trieval and Land Data Assimilation System Development in a Typical Inland River Basin of Chinas Arid Region (ID 5322) aims at improving the monitoring, understand- ing, and predictability of hydrological and ecological pro- cesses at catchment scale, and promote the applicability of quantitative remote sensing in watershed science. Ex- isting Earth Observation platforms provided by the Euro- pean Space Agency as well as prototype airborne systems developed in China - ENVISAT/AATSR, ALOS/PRISM and PALSAR, Airborne LIDAR - are used and combined to retrieve advanced land surface physical properties over high elevation arid regions of China. The existing syn- ergies between this project, the CEOP-AEGIS project (FP7) and the WATER project (CAS) provide incentives for innovative studies. The investigations presented in the following report focus on the development of advanced and innovative methodologies and algorithms to monitor both the state and the trend of key eco-hydrological vari- ables: 3D vegetation properties, land surface evaporation, glacier mass balance and drought indicators.
The Role of Histone Deacetylase and DNA Methylation in Estrogen a Expression in Breast Cancer

DTIC Science & Technology

2001-06-01

ever, in other cases, both demethylation and HDAC inhibition appear to be necessary. For example, certain hypermethylated genes like 231C MLH1 , TIMP3...Treatment of these cells with the demethylat- permethylated genes, such as MLH1 , TIMP3, INK4B ing agent, deoxyC, led to partial demethylation of the (p15
Product development in large furniture companies: a descriptive model with implications for character-marked products

Treesearch

Matt Bumgardner; Robert J. Bush; Cynthia D. West

2001-01-01

Previous research has shown that substantial yield improvements are possible when character-marks are not removed from hardwood furniture parts. Attempts to promote increased use of character-marked wood in fumiture should be based on an understimn&ing of how design concepts originate and move through the stages of product development. However, very little has...
Protect Your Baby from Bleeds: Talk to Your Healthcare Provider about Vitamin K

MedlinePlus

... a shot into a muscle in the leg. One shot given after birth will protect your baby from ... warning signs of VKDB? In the majority of cases of VKDB, there are NO WARN- ING SIGNS at all before a ... Vitamin K safe? A study from the early 1990’s found a possible link ...
Evaluation of Telepathology Systems and Practices

DTIC Science & Technology

2009-01-01

scaJlIIing >!ideo and pMlin& lhe digitized imogfi on ~ ond uansmining lhem ov..,. compur..,. necWOfU. This proceso perrnilS independmt ’’’’’’’ing of...Roberts, MD, MPP Professor of Medicine, Health Policy and Management and Industrial Engineering Chief, Section of Decision Sciences and Clinical Systems
Revisiting forest road retirement

Treesearch

Randy Kolka; Mathew Smidt

2001-01-01

Determining the sources of nonpoint source pollution in a watershed is difficult, although the largest source of sediment in forested systems is from skld trails, haul roads, and landings associated with forest harvest- ing (Ketcheson et al., 1999; Swft, 1988) The transport of sediment to streams and subsequent sedimentation leads to the loss of...
Worldwide Report, Arms Control.

DTIC Science & Technology

1986-02-04

the other dide, and thus deliberately blind it, unexpectedly occupy it, and thus paralyze it, or completely deny it a retaliatory strike. Third ... space weapons 4,000-5,000 km away can be regarded as practically a universal weapon. Such a weapon can be used for fiülfilüing offensive tasks and
40 CFR 403.7 - Removal credits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND NEW SOURCES OF POLLUTION § 403.7 Removal credits. (a... system. Removal as used in this subpart shall not mean dilution of a pollutant in the POTW. (ii) Sludge... D of SWDA); the Clean Air Act; the Toxic Substances Control Act; and the Marine Protection, Research...
Chapter 6. Landscape Analysis for Habitat Monitoring

Treesearch

Samuel A. Cushman; Kevin McGarigal; Kevin S. McKelvey; Christina D. Vojta; Claudia M. Regan

2013-01-01

The primary objective of this chapter is to describe standardized methods for measurÂ¬ing and monitoring attributes of landscape pattern in support of habitat monitoring. This chapter describes the process of monitoring categorical landscape maps in which either selected habitat attributes or different classes of habitat quality are represented as different patch types...
Unions' Deals with Brokers Raise Issues

ERIC Educational Resources Information Center

Jacobson, Linda

2006-01-01

The New York state attorney general's office is close to announcing a settlement with the 525,000-member New York State United Teachers over a relationship between the union and ING Group, a large financial-services company based in the Netherlands. In that arrangement, the union's Member Benefits division--a separate trust that provides…
INVESTIGATION OF THE USE OF ISOCYANATE ADDUCTS IN URETHANE FOAM

DTIC Science & Technology

The fea ibility of a one-can, delayed action foaming system was successfully d monstra e . A literary arch revealed that y co poun s po e ing...ctive ydrogens may react with organic isocyanates to produce heat-s nsitive adducts. T HESE D UCT YI LD BACK THE ORIGINAL ISOCY N TE AND THE

Noun or Verb? Adult Readers' Sensitivity to Spelling Cues to Grammatical Category in Word Endings

ERIC Educational Resources Information Center

Kemp, Nenagh; Nilsson, Jodi; Arciuli, Joanne

2009-01-01

The spelling of many disyllabic English word endings holds cues to their grammatical category, beyond obvious inflectional endings such as "-ing" for verbs. For example, some letter sequences are clearly associated with nouns (e.g., "-oon") and others with verbs (e.g., "-erge"). This study extended recent research by Arciuli and Cupples (2006),…
Approaches to S&T Cost Modeling at the U.S. Air Force Research Laboratory/Vehicle Aeronautics Directorate

DTIC Science & Technology

2000-09-01

fassent, si rien ne change par ailleurs. plus proche de l’ing~ni~rie du vivant . Une vdritable optimisation des 6ldinents de soutien logistique A bord...s souvent dans les arbres l’utilisation en service. fonctionnels, peuvent 8tre recueillies plus facilement dans un tableau crois6 avec les divers syst
Embedded Incremental Feature Selection for Reinforcement Learning

DTIC Science & Technology

2012-05-01

Prior to this work, feature selection for reinforce- ment learning has focused on linear value function ap- proximation ( Kolter and Ng, 2009; Parr et al...InProceed- ings of the the 23rd International Conference on Ma- chine Learning, pages 449–456. Kolter , J. Z. and Ng, A. Y. (2009). Regularization and feature
Everything is Not a Process: Products, Games and Emerging Metaphors for Work

DTIC Science & Technology

2012-02-01

intriguing metaphors for work to emerge in re- cent years is to describe it as a game. Jane McGonigal is a lead- ing expert on “ gamification ,” and her...descriptions, to include a gamified approach, when making decisions and taking action. Ultimately, whether we call it a process, a journey, or a game
Performance Learning Roadmap A Network-Centric Approach for Engaged Learners

DTIC Science & Technology

2005-01-01

Insurance Corporation Target Corporation Unilever Corporation United Nations Development Programme University of Wisconsin (UWSA)–Madison U.S. Coast Guard...performance support services, including consulting, coaching, mentoring, rapid 14 deployment training, targeted training, analysis , facilitation, and team...services include consulting, coaching, mentoring, rapid deployment training, targeted train- ing, analysis , facilitation, and team collaboration support
Post Retort, Pre Hydro-treat Upgrading of Shale Oil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gordon, John

Various oil feedstocks, including oil from oil shale, bitumen from tar sands, heavy oil, and refin- ery streams were reacted with the alkali metals lithium or sodium in the presence of hydrogen or methane at elevated temperature and pressure in a reactor. The products were liquids with sub- stantially reduced metals, sulfur and nitrogen content. The API gravity typically increased. Sodi- um was found to be more effective than lithium in effectiveness. The solids formed when sodium was utilized contained sodium sulfide which could be regenerated electrochemically back to so- dium and a sulfur product using a "Nasicon", sodium ionmore » conducting membrane. In addition, the process was found to be effective reducing total acid number (TAN) to zero, dramatically reduc- ing the asphaltene content and vacuum residual fraction in the product liquid. The process has promise as a means of eliminating sulfur oxide and carbon monoxide emissions. The process al- so opens the possibility of eliminating the coking process from upgrading schemes and upgrad- ing without using hydrogen.« less
Transparent Lu 2 O 3 :Eu ceramics by sinter and HIP optimization

NASA Astrophysics Data System (ADS)

Seeley, Z. M.; Kuntz, J. D.; Cherepy, N. J.; Payne, S. A.

2011-09-01

Evolution of porosity and microstructure was observed during densification of lutetium oxide ceramics doped with europium (Lu 2O 3:Eu) fabricated via vacuum sintering and hot isostatic pressing (HIP'ing). Nano-scale starting powder was uniaxially pressed and sintered under high vacuum at temperatures between 1575 and 1850 °C to obtain densities ranging between 94% and 99%, respectively. Sintered compacts were then subjected to 200 MPa argon gas at 1850 °C to reach full density. Vacuum sintering above 1650 °C led to rapid grain growth prior to densification, rendering the pores immobile. Sintering between 1600 and 1650 °C resulted in closed porosity yet a fine grain size to allow the pores to remain mobile during the subsequent HIP'ing step, resulting in a fully-dense highly transparent ceramic without the need for subsequent air anneal. Light yield performance was measured and Lu 2O 3:Eu showed ˜4 times higher light yield than commercially used scintillating glass indicating that this material has the potential to improve the performance of high energy radiography devices.
Relationships Between Habitat and Snag Characteristics and the Reproductive Success of the Brown-headed Nuthatch (Sitta pusilla) in Eastern Texas

Treesearch

L. Lynnette Dornak; D. Brent Burt; Dean W. Coble; Richard N. Conner

2004-01-01

Habitat use and reproductive success of the Brown-headed Nuthatch (Sitta pusilla Latham) were studied in East Texas during the 2001Â2002 breed- ing seasons. We compared nest cavity selection at used and randomly selected non-used areas. Height of nest trees, midstory density, and percent leaf litter were negatively correlated with nest site selection...
The Coast Artillery Journal. Volume 81, Number 2, March-April 1938

DTIC Science & Technology

1938-04-01

in that hectic area known as Mittel- europa . It ranks with the British navy and the Russian air force; all three of them are tops. 51’, JOliN’S ell...gunner’s quadrant . Point- ing is accomplished by means of Model 1917 panoramic sight. The ammunition consists of I-inch specially-ma- chined steel
AMAR: A Computational Model of Autosegmental Phonology

DTIC Science & Technology

1993-10-01

iirjpliologv i td lat Ia iiglia’t.. liitcad. it iiilistitclv li k iii~ hrl~ ielt -f)rcr, iiwietlid’ te I rv to) siilt oii(aeiti. iu~ilg .III a coiiealt-iatlvix...Summiier Institute of Linguistics. Inc. 1 -253. Occasional Publications in Academic C om- put ing. Barton, G. E.. R. CI. Berwick, and E. S. Rista&I
Aircraft Crash Survival Design Guide. Volume 2. Aircraft Crash Environment and Human Tolerance

DTIC Science & Technology

1980-01-01

anthropometry , and crash test dummies, all of which serves as background for the design information presented in the other volumes. .I / V. L...Aeromedical Institute furnished assistance in locat- ing recent information on human tolerance, anthropometry , and crash test dummies. .3 TABLE OF CONTENTS...83 6.1 INTRODUCTION . . . . . . .. ..... 83 6.2 ANTHROPOMETRY . . . . . . 83 6.2.1 Conventional Anthropometric Measurements
40 CFR 403.19 - Provisions of specific applicability to the Owatonna Waste Water Treatment Facility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOR EXIST-ING AND NEW SOURCES OF POLLUTION § 403.19 Provisions of specific applicability to the... Facility is equal to or less than 0.68 pounds per day of chromium, 0.25 pounds per day of copper, 1.17... Noncompliance subject to the publication requirement in § 403.8(f)(2)(vii) at the Minnesota Pollution Control...
Neutralization of Home Made Explosives (HME) Hazards

DTIC Science & Technology

2015-04-28

Octob previous wo nding levels n achieving neral . More B – Explosiv September rch Centre HME Threa ing CIED/EO . ED Disrupte e Test & Ev 1-120, 201...testing ar 204RD, and he choice of mixtures us neral observ hosen mixtu lations. are large a y of water je se of veloci ction. consistency tability
Skirmishing around Carlisle - 1863,

DTIC Science & Technology

1986-04-01

planned to accompany the column, was held up at Brioqepr,-t most of the day by the uniil ingness of the I lth Heavu Artillery e ,. US_ Volunteers to join...34 enough to have their property struck by a shell later placed small metal plaques or, their buildings that read., "July 1, 1863." At Carlisle Barracks
40 CFR 403.4 - State or local law.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 29 2011-07-01 2009-07-01 true State or local law. 403.4 Section 403.4... GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND NEW SOURCES OF POLLUTION § 403.4 State or local law... prohibitions, established by State or local law as long as the State or local requirements are not less...
Building Theories: The Three Worlds of Mathematics

ERIC Educational Resources Information Center

Tall, David

2004-01-01

In this commentary on Matthew Inglis' "Three Worlds and the Imaginary Sphere" (see EJ1106688), David Tall develops the theme that the building of theories is not an easy process. A theory in progress is a particularly delicate creation. Theories do not appear fully formed. There is a period of exploration and incubation that precedes the…
Recovery of Monkeys After Myocardial Infarction with Ventricular Fibrillation. Effects of PGB

DTIC Science & Technology

1980-01-01

stress5 ,0 a new bioregulatory factor was dis- ing to hypoxia and acidosis is associated with covered with the unique property of conserv- biochemical...with 5% glutaralde- bovine serum albumin to give a final mixture hyde in 0.1 M phosphate buffer, pH 7.4. At of 2.2 ml. AMP and ADP were added as 30
The Emperor’s New Password Manager: Security Analysis of Web-based Password Managers

DTIC Science & Technology

2014-07-07

POST re- quest, LastPass will store h’ as authenticating Alice. Mallory can then use otp’ to log-in to LastPass us- ing otp’. Of course , decrypting the...everywhere. [36] M. Rochkind. Security, forms, and error handling. In Expert PHP and MySQL , pages 191–247. Springer, 2013. [37] D. Silver, S. Jana, E
Alternative Methods of Base Level Demand Forecasting for Economic Order Quantity Items,

DTIC Science & Technology

1975-12-01

Note .. . . . . . . . . . . . . . . . . . . . . . . . 21 AdaptivC Single Exponential Smooti-ing ........ 21 Choosing the Smoothiing Constant... methodology used in the study, an analysis of results, .And a detailed summary. Chapter I. Methodology , contains a description o the data, a...Chapter IV. Detailed Summary, presents a detailed summary of the findings, lists the limitations inherent in the 7’" research methodology , and
Reference Manual, Background Materials for the CONUS Volumes,

DTIC Science & Technology

1983-04-25

operating cathode tube. He demonstrated that invisible rays emanating from the cathode tube were responsible for darken- ing the film. He called these...N 141 - - -. , * -.. *** *** ~ .*.( .*~- - ’.- - * -.-. - -. APPENDIX B (continued) AM n i in vi U% V’ I-I- 4 i nCA 4 CA le3 i 3 A .US w4 w’ . a L" P

Spectral Domain RF Fingerprinting for 802.11 Wireless Devices

DTIC Science & Technology

2010-03-01

induce unintentional modulation effects . If these effects (features) are sufficiently unique, it becomes possible to identify a device us- ing its...Previous AFIT research has demonstrated the effectiveness of RF Fin- gerprinting using 802.11A signals with 1) spectral correlation on Power Spectral...32 4.5. SD Intra-manufacturer Classification: Effects of Burst Location Error
40 CFR 403.4 - State or local law.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true State or local law. 403.4 Section 403.4... GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND NEW SOURCES OF POLLUTION § 403.4 State or local law... prohibitions, established by State or local law as long as the State or local requirements are not less...
Improving Capabilities for Irregular Warfare. Volume 2. Capabilities Analysis

DTIC Science & Technology

2007-08-01

from a build- ing. CPT Jon E. Tellier , USA, “The Battle for Hue.” Infantry (July–August 1995): p. 24. However, the US ratification in 1997 of the...Jane’s International Defense Review (1 February 2006). Tellier , Jon E. “The Battle for Hue.” Infantry (July–August 1995): pp. 21–26. Thomas, Timothy L
Sleep and Alertness Management II: Effects on Sleep Pattern and Sleep Quality in Marmosets (slaap- en alertheidsmanagement II: effecten op slaapritme en slaapkwaliteit in marmosetapen)

DTIC Science & Technology

2006-10-01

beleidsondersteuning Commando Luchtstrijdkrachten/Hoofd Auteur (s) Afdeling Gezondheidszorg operaties dr. I.H.C.H.M. Philippens, R.A.P. Vanwersob, ing. M.J... Theory .......................................................................................................................... 9 2.1 Sleep as an...2 Theory 2.1 Sleep as an active and rhythmical process Till the 50s the research on sleep was dominated by a passive theory of sleep. This theory
Guide to wildlife tree management in New England northern hardwoods

Treesearch

Carl H. Tubbs; Richard M. DeGraaf; Mariko Yamasaki; William M. Healy

1987-01-01

Presents information on the culture and management of trees that have value as components of wildlife habitat in the northern hardwood and associated types in New England. Background information is provided for choosing the most suitable trees for wildlife habitats and for estimat ing the impact of timber production. Suggestions are made for choosing the numbers of...
Dredging: An Annotated Bibliography on Operations, Equipment, and Processes. Revision.

DTIC Science & Technology

1982-03-01

establishing producing centers, enterprises, financial planning, and technical specifications for plant and equipment. Drilling and laboratory results are...summarised, and resource, market, technological and environmental bases described. Prospect drilling of calcareous sandstone (kurkar and calcarenite...Automation; Pumps and impellers; Cavitation; Cost and econ- omy of dredging; Drilling and blasting; Spoil disposal; Deep sea dredg- ing; River dredging
Defining a Rule for the Use of Infinitive and Gerund Complements

ERIC Educational Resources Information Center

Conti, Gregory

2011-01-01

This essay formulates a rule for the use of the to+verb and verb+ing finite complements designed to help students and teachers of English as a foreign language. The rule results from an analysis of the distinction between the directional function and inceptive aspect of the to+verb form, rooted in the prepositional origins of to, and the…
Nutrient Recycling Impacts by Zebra Mussels in Harper’s Ferry Slough, Upper Mississippi River

DTIC Science & Technology

2000-12-01

ing pro duc tiv ity in the slough (also see Caraco et al. (1997)). In Harper’s Ferry Slough and other aquatic sys tems, the mag ni tude of ze bra mus...the Upper Mississippi River with zebra mussels (Dreissena polymorpha),” Environ. Sci. Technol. 33, 4385-4390. ERDC WQTN-PD-07 December 2000 11 Caraco , N
Measuring Thermal Performance of Building Envelopes: Nine Case Studies,

DTIC Science & Technology

1985-03-01

inch P/B = 11.36, present worth factor for an es- of expanded polystyrene insulation) to the build- calating series for a 15-year period ing exterior...inch of The one MCA building roof we measured was a expanded polystyrene at R-3.6 per inch. Where the cathedral system with a sloped built-up roofing
Long-Term Implications of the 2013 Future Years Defense Program

DTIC Science & Technology

2012-07-01

difficult for the department to manage because it would need to be achieved in only nine months (between the cut’s tak - ing effect in January 2013 and the...Estimate of DoD’s Funding Under the BCA Caps After Automatic Reductionse 469 472 475 477 480 483 485 487 489 493 d Nominal Dollars 2013 Dollars 2022
A Design for a Multi-Use Object Editor with Connections

DTIC Science & Technology

1991-10-01

Variables of Class Select 14 3.6.2 Methods of Class Select 14 3.6.3 Application States 14 3.7 Class Clipboard 15 3.8 Class Crestore 15 3.9 Conclusions 15 4...this is not directly related to cutting and past- ing between applications. 3.8 CLASS CRESTORE Class crestore holds a connection until all the
On becoming "Wide-Awake": Artful Re-Search and Co-Creative Process as Teacher Development

ERIC Educational Resources Information Center

Mantas, Kathy; Di Rezze, Gianna

2011-01-01

In this essay we reference a co-creative art installation entitled Box-ing In/Out (Di Rezze & Mantas, 2006; Mantas, 2004). Through this collaborative project we describe how artful re-search and the co-creative process can help teachers access and reframe tacit understandings of teaching and learning. We argue that the personal meaning making,…
A Combined Arms Approach to Defending Army Networks

DTIC Science & Technology

2012-01-01

GIG operates, through cyberspace, as a globally interconnected, end...operations from the friendly to adversary box increases the situational awareness and unity of effort the Army lacks, and creates an economy of force that...indica- tions and warnings • Present a timely and accurate estimate of technical impact result- ing from the threat activity and determine
Saudi Arabia: Modernity, Stability, and the Twenty-First Century Monarchy

DTIC Science & Technology

2015-06-01

one of the feud- ing Saudi leaders was just too great a temptation .67 The end result was the destruction of the Second Saudi State and its occupation...the Shah who waited until after Ford lost the election to send him a response declaring that Iran would not “commit suicide ” because the West could
The Ukrainian Crisis and European Security: Implications for the United States and U.S. Army

DTIC Science & Technology

2015-01-01

Finland . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 New Uncertainties in the Black Sea Region...increas- ing pressure if Putin is successful in destabilizing eastern Ukraine. Putin’s Increasing Commitment to the Pro -Russian Separatists Since the...downing of the MH17 commercial airliner in July 2014, Russia has increased weapon deliveries to the pro -Russian rebels, as well as the firepower of
Progress Toward a Monolithically Integrated Coherent Diode Laser Array.

DTIC Science & Technology

1981-02-20

eoCteehinique is uised extensively in fabricat ing MBR I iseor, ind pi~ rovide,, adidi t iooat infornation on the quality of the crystal. \\BR CAI FBR AI) \\R...crystals are then cleaned in hot isopropyl alcohol held in a vertical position by a glass holder submerged in isopropyl alcohol. They soak for about 1 hr
Impulsively-Started Flow about Submarine-Shaped Bodies.

DTIC Science & Technology

1981-03-01

extended by Goldstein and Rosenhead [7] in 1936, G6rtler [8,9] in 1944 and 1948, Schuh [10] in 1953, Watson [11] in 1955, and Wundt [12] in 1955. It...231, pp. 104-116, 1955. 12. Wundt , H., "Wachstum der Laminaren Grenzschicht an schrag angestromten Zylindren bei Anfahrt aus der Ruhe," Ing.- Arch., Vol
Consequence Management Symposium

DTIC Science & Technology

2001-09-01

AND SUBTITLE Consequence Management Symposium 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...log i cal agents and their effects was deemed essen tial for “first respond ers,” includ ing emer gency medi cal and hospi tal prac ti tio ners
Frigate Defense Effectiveness in Asymmetrical Green Water Engagements

DTIC Science & Technology

2009-09-01

the model not employ- ing a helicopter, a high overlap in the sets of factors determining loss is observed. Both factor weighting and the predicted...61 4.1 Model Parameter Estimates Overview. . . . . . . . . . . . . . . . . . . . . . 69 4.2 Distribution of loss ...74 4.7 The range at which a contact is deemed hostile has low impact on predicted loss
Vital Signs Rate Meter.

DTIC Science & Technology

1987-09-01

stethoscope . Auscultation in respiratory medicine, however, has advanced slowly since Laennec established auscultation of lung sounds as a means of... stethoscope and the ear have limitations in their use as instruments for the evaluation of respiratory sounds. Respiratory sounds have a wide spectrum...Amplification, Rectification and Level-shft ing Stage ... 11 Respiratory Sound Circuitry ....... .................. ... 11 Sound Sensor

Machine Arithmetic in Residual Classes,

DTIC Science & Technology

1981-04-03

its sign. Be-ing congruqnt/egquating with zesp -ct to the value two nlmr’:s, * " we judge that, which of the numbers mcre cn the sign of differr’.ce. The...addition to the modulus/modulea. Page 322 . The fact is that the inversion cf the digit, undertaken or. basi-/ba> ,. is the fcrmation/educaticn of addition
Information Technology and the Evolution of the Library

DTIC Science & Technology

2009-03-01

Resource Commons/ Repository/ Federated Search ILS (GLADIS/Pathfinder - Millenium)/ Catalog/ Circulation/ Acquisitions/ Digital Object Content...content management services to help centralize and distribute digi- tal content from across the institution, software to allow for seamless federated ... search - ing across multiple databases, and imaging software to allow for daily reimaging of ter- minals to reduce security concerns that otherwise
Novel Applications of a Thermally Tunable Bistable Buckling Silicon-on-Insulator (SOI) Microfabricated Membrane

DTIC Science & Technology

2015-09-17

applications, a tunable pressure sensor and a steerable micromirror . A differential pressure across the mem- brane causes deflection, up or down, which can...0.55µm/psi. A steerable micromirror was realized by selectively heat- ing a single quadrant of a buckled membrane, localized heating results in membrane...124 6.2.1 Micromirror Actuator Optimization . . . . . . . . . . . . . . . . . . . . . . . . 124 6.3 Summary
Optimization of Shielding- Collimator Parameters for ING-27 Neutron Generator Using MCNP5

NASA Astrophysics Data System (ADS)

Hegazy, Aya Hamdy; Skoy, V. R.; Hossny, K.

2018-04-01

Neutron generators are now used in various fields. They produce only fast neutrons; D-D neutron generator produces 2.45 MeV neutrons and D-T produces 14.1 MeV neutrons. In order to optimize shielding-collimator parameters to achieve higher neutron flux at the investigated sample (The signal) with lower neutron and gamma rays flux at the area of the detectors, design iterations are widely used. This work was applied to ROMASHA setup, TANGRA project, FLNP, Joint Institute for Nuclear Research. The studied parameters were; (1) shielding-collimator material, (2) Distance between the shielding-collimator assembly first plate and center of the neutron beam, and (3) thickness of collimator sheets. MCNP5 was used to simulate ROMASHA setup after it was validated on the experimental results of irradiation of Carbon-12 sample for one hour to detect its 4.44 MeV characteristic gamma line. The ratio between the signal and total neutron flux that enters each detector was calculated and plotted, concluding that the optimum shielding-collimator assembly is Tungsten of 5 cm thickness for each plate, and a distance of 2.3 cm. Also, the ratio between the signal and total gamma rays flux was calculated and plotted for each detector, leading to the previous conclusion but the distance was 1 cm.
Rho'ing in and out of cells: viral interactions with Rho GTPase signaling.

PubMed

Van den Broeke, Céline; Jacob, Thary; Favoreel, Herman W

2014-01-01

Rho GTPases are key regulators of actin and microtubule dynamics and organization. Increasing evidence shows that many viruses have evolved diverse interactions with Rho GTPase signaling and manipulate them for their own benefit. In this review, we discuss how Rho GTPase signaling interferes with many steps in the viral replication cycle, especially entry, replication, and spread. Seen the diversity between viruses, it is not surprising that there is considerable variability in viral interactions with Rho GTPase signaling. However, several largely common effects on Rho GTPases and actin architecture and microtubule dynamics have been reported. For some of these processes, the molecular signaling and biological consequences are well documented while for others we just begin to understand them. A better knowledge and identification of common threads in the different viral interactions with Rho GTPase signaling and their ultimate consequences for virus and host may pave the way toward the development of new antiviral drugs that may target different viruses.
CeasIng Cpap At standarD criteriA (CICADA): Implementation improves neonatal outcomes.

PubMed

Heath Jeffery, Rachael C; Broom, Margaret; Shadbolt, Bruce; Todd, David A

2016-03-01

A previous randomised controlled trial (RCT) in babies born < 30 weeks gestation found the so-called CICADA method (ceasing continuous positive airways pressure (CPAP) with a view to remain off rather than slow weaning) significantly reduced CPAP time. Post-RCT we introduced the CICADA method and evaluated whether the improved outcomes of the CICADA method during the RCT were replicated in clinical practice. The aim of the study is to compare cardio-respiratory outcomes in PBs < 30 weeks GA over three epochs: (i) pre RCT, (ii) during RCT and (iii) post RCT implementation. The study used prospective data to compare baseline characteristics and cardio-respiratory outcomes over the three epochs. There were 270/393(69%) PBs < 30 weeks GA who fulfilled the inclusion criteria over the three epochs. No significant differences were found in GA or birthweight between the three epochs (27.9 ± 1.3, 27.7 ± 1.4, 28.0 ± 1.3 (weeks ± 1 standard deviation); and 1100 ± 252, 1086 ± 251, 1094 ± 320 (grams ± 1 standard deviation)). There were significant decreases in CPAP days and corrected GA to cease CPAP post implementation (20.5 ± 2.1, 21.1 ± 2.1, 16.5 ± 1.8 (days ± SE); P = 0.006 and 33.3 ± 0.4, 33.5 ± 0.4, 32.6 ± 0.4 (weeks ± SE); P = 0.01). Compared with the pre RCT epoch, there were significant reductions in patent ductus arteriosus (36/78 (46%), 33/87 (37%), 18/103 (17%); P < 0.001) and chronic lung disease (40/78 (51%), 19/87 (21%), 30/103 (29%); P < 0.001). CPAP time, corrected GA to cease CPAP, patent ductus arteriosus and chronic lung disease significantly reduced following the introduction of the CICADA method. Early cessation of CPAP expedites the transition from neonatal intensive care to special care. © 2016 The Author. Journal of Paediatrics and Child Health © 2016 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
EFL Learners' Grammatical Awareness through Accumulating Formulaic Sequences of Morphological Structure (-ing)

ERIC Educational Resources Information Center

Kashiwagi, Kazuko; Ito, Yukiko

2017-01-01

Even young EFL learners who have not yet learned L2 grammar will notice language patterns if, when retrieving exemplars ("item-based patterns"), they succeed in making form-meaning connections (FMCs). Item-based patterns, termed formulaic sequences (FS), serve as a basis for creative constructions. Although learners are implicitly…
Text(ing) in Context: The Future of Workplace Communication in the United States

ERIC Educational Resources Information Center

Kiddie, Thomas J.

2014-01-01

Following Rogers's theory of the diffusion of innovations, the author questions whether youth entering the workforce will act as change agents to evolve primary business communication channels from email to text-messaging. Expanding on research performed in 2009, the author investigates three communication scenarios: scheduling meetings,…
Race-ing Class Ladies: Lineages of Privilege in an Elite South African School

ERIC Educational Resources Information Center

Epstein, Debbie

2014-01-01

This paper draws on fieldwork done in Greystone School in South Africa, a single sex girls' school. I explore how the legacy of coloniser and colonised is reconfigured through the history of the school and the particular racialised politics of South Africa, where race and class have always been imbricated in differently nuanced ways before, during…
Humor-ing the Local: Multivocal Performance in Stand-Up Comedy in Hawai'i

ERIC Educational Resources Information Center

Furukawa, Toshiaki

2011-01-01

This dissertation takes a discursive approach to Hawai'i stand-up comedy, which is a highly dramaturgical genre, and it examines the cultural specificity of Hawaii comedy in an explicitly interactional context. This culturally-specific performative genre is a discursive site where comedians and their audiences jointly construct multivocal humor…
"Brown"-ing the American Textbook: History, Psychology, and the Origins of Modern Multiculturalism

ERIC Educational Resources Information Center

Zimmerman, Jonathan

2004-01-01

This article discusses the struggles over school textbooks to probe America's postwar discourse about race, highlighting the shift towards psychological modes of explanation and remedy. The first section examines debates in the North during the 1940s and early 1950s when a new cohort of African-American freedom fighters--the so-called "World War…
VizieR Online Data Catalog: Quasi-periodic pulsations in solar flares (Inglis+, 2016)

NASA Astrophysics Data System (ADS)

Inglis, A. R.; Ireland, J.; Dennis, B. R.; Hayes, L.; Gallagher, P.

2018-04-01

We have used data from the Geostationary Operational Environmental Satellite (GOES) instrument series, and from Fermi/Gamma-ray Burst Monitor (GBM). For this reason, we choose the interval 2011 February 1 - 2015 December 31, as it not only coincides with the availability of GOES-15 satellite data, but also includes regular solar observations by GBM. GOES satellites are equipped with solar X-ray detectors that record the incident flux in the 0.5-4Å and 1-8Å wavelength ranges. Solar X-ray data from the most recent satellite, GOES-15, has been available since 2010 at a nominal 2s cadence. To access the GOES catalog, we use the Heliophysics Event Knowledgebase (HEK). Fermi/GBM operates in the 8keV-40MeV range and regularly observes emission from solar flares, with a solar duty cycle of ~60%, similar to the solar-dedicated Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). To accumulate the database of Fermi/GBM events, we use the GBM trigger catalog produced by the instrument team, selecting all events marked as flares. (2 data files).
Managing Race and Race-ing Management: Teachers' Stories of Race and Classroom Conflict

ERIC Educational Resources Information Center

Deckman, Sherry L.

2017-01-01

Background/Context: Research exploring suspension and expulsion practices suggests that teachers may play a key role in perpetuating racial disproportionality in school discipline by interpreting student behavior through racialized and racist lenses and by viewing the behavior of students of color as an affront to their authority, resulting in…
Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain

PubMed Central

Poplawski, Amanda; Hu, Kaifeng; Lee, Woonghee; Natesan, Senthil; Peng, Danni; Carlson, Samuel; Shi, Xiaobing; Balaz, Stefan; Markley, John L.; Glass, Karen C.

2014-01-01

The monocytic leukemic zinc-finger (MOZ) histone acetyltransferase (HAT) acetylates free histones H3, H4, H2A, and H2B in vitro and is associated with up-regulation of gene transcription. The MOZ HAT functions as a quaternary complex with the bromodomain-PHD finger protein 1 (BRPF1), inhibitor of growth 5 (ING5), and hEaf6 subunits. BRPF1 links the MOZ catalytic subunit to the ING5 and hEaf6 subunits, thereby promoting MOZ HAT activity. Human BRPF1 contains multiple effector domains with known roles in gene transcription, and chromatin binding and remodeling. However, the biological function of the BRPF1 bromodomain remains unknown. Our findings reveal novel interactions of the BRPF1 bromodomain with multiple acetyllysine residues on the N-terminus of histones, and show it preferentially selects for H2AK5ac, H4K12ac and H3K14ac. We used chemical shift perturbation data from NMR titration experiments to map the BRPF1 bromodomain ligand binding pocket and identified key residues responsible for coordination of the post-translationally modified histones. Extensive molecular dynamics simulations were used to generate structural models of bromodomain-histone ligand complexes, to analyze H-bonding and other interactions, and to calculate the binding free energies. Our results outline the molecular mechanism driving binding specificity of the BRPF1 bromodomain for discrete acetyllysine residues on the N-terminal histone tails. Together these data provide insights on how histone recognition by the bromodomain directs the biological function of BRPF1, ultimately targeting the MOZ HAT complex to chromatin substrates. PMID:24333487
Extraterrestrial Amino Acids in the Almahata Sitta Meteorite

NASA Technical Reports Server (NTRS)

Glavin, Daniel P.; Aubrey, Andrew D.; Callahan, Michael P.; Dworkin, Jason P.; Elsila, Jamie E.; Parker, Eric T.; Bada, Jeffrey L.

2009-01-01

Amino acid analysis of a meteorite fragment of asteroid 2008 TC(sub 3) called Almahata Sitta was carried out using reverse-phase high-perfo rmance liquid chromatography coupled with UV fluorescence detection a nd time-of-flight mass spectrometry (HPLC-FD/ToF-MS) as part of a sam ple analysis consortium. HPLC analyses of hot-water extracts from the meteorite revealed a complex distribution of two- to six-carbon aliph atic amino acids and one- to three carbon amines with abundances rang ing from 0.5 to 149 parts-per-billion (ppb). The enantiomeric ratios of the amino acids alanine, Beta-amino-n-butyric acid (Beta-ABA), 2-amino-2- methylbutanoic acid (isovaline), and 2-aminopentanoic acid (no rvaline) in the meteorite were racemic (D/L approximately 1), indicat ing that these amino acids are indigenous to the meteorite and not te rrestrial contaminants. Several other non-protein amino acids were also identified in the meteorite above background levels including alpha -aminoisobutyric acid (alpha-AIB), 4-amino-2- methybutanoic acid, 4-a mino-3-methylbutanoic acid, and 3-, 4-, and 5-aminopentanoic acid. Th e total abundances of isovaline and AlB in Almahata Sitta are approximately 1000 times lower than the abundances of these amino acids found in the CM carbonaceous meteorite Murchison. The extremely love abund ances and unusual distribution of five carbon amino acids in Almahata Sitta compared to Cl, CM, and CR carbonaceous meteorites and may be due to extensive thermal alteration of amino acids on the parent aster oid by partial melting during formation or impact shock heating.
Packaged die heater

DOEpatents

Spielberger, Richard; Ohme, Bruce Walker; Jensen, Ronald J.

2011-06-21

A heater for heating packaged die for burn-in and heat testing is described. The heater may be a ceramic-type heater with a metal filament. The heater may be incorporated into the integrated circuit package as an additional ceramic layer of the package, or may be an external heater placed in contact with the package to heat the die. Many different types of integrated circuit packages may be accommodated. The method provides increased energy efficiency for heating the die while reducing temperature stresses on testing equipment. The method allows the use of multiple heaters to heat die to different temperatures. Faulty die may be heated to weaken die attach material to facilitate removal of the die. The heater filament or a separate temperature thermistor located in the package may be used to accurately measure die temperature.
One precursor, three apolipoproteins: the relationship between two crustacean lipoproteins, the large discoidal lipoprotein and the high density lipoprotein/β-glucan binding protein.

PubMed

Stieb, Stefanie; Roth, Ziv; Dal Magro, Christina; Fischer, Sabine; Butz, Eric; Sagi, Amir; Khalaila, Isam; Lieb, Bernhard; Schenk, Sven; Hoeger, Ulrich

2014-12-01

The novel discoidal lipoprotein (dLp) recently detected in the crayfish, differs from other crustacean lipoproteins in its large size, apoprotein composition and high lipid binding capacity, We identified the dLp sequence by transcriptome analyses of the hepatopancreas and mass spectrometry. Further de novo assembly of the NGS data followed by BLAST searches using the sequence of the high density lipoprotein/1-glucan binding protein (HDL-BGBP) of Astacus leptodactylus as query revealed a putative precursor molecule with an open reading frame of 14.7 kb and a deduced primary structure of 4889 amino acids. The presence of an N-terminal lipid bind- ing domain and a DUF 1943 domain suggests the relationship with the large lipid transfer proteins. Two-putative dibasic furin cleavage sites were identified bordering the sequence of the HDL-BGBP. When subjected to mass spectroscopic analyses, tryptic peptides of the large apoprotein of dLp matched the N-terminal part of the precursor, while the peptides obtained for its small apoprotein matched the C-terminal part. Repeating the analysis in the prawn Macrobrachium rosenbergii revealed a similar protein with identical domain architecture suggesting that our findings do not represent an isolated instance. Our results indicate that the above three apolipoproteins (i.e HDL-BGBP and both the large and the small subunit of dLp) are translated as a large precursor. Cleavage at the furin type sites releases two subunits forming a heterodimeric dLP particle, while the remaining part forms an HDL-BGBP whose relationship with other lipoproteins as well as specific functions are yet to be elucidated.
Disrupting Threat Finances: Using Financial Information to Disrupt Terrorist Organizations

DTIC Science & Technology

2008-04-01

remittance systems, stored value cards, digital currency , and Islamic banking; b) not-for-profit organizations, including front organizations and...including cash couriers; alternative remittance systems “informal value transfer,” such as hawalas and hundis; stored value cards; digital currency ...work with other federal agencies to implement key statutory provisions of the Currency and Foreign Transactions Report- ing Act (commonly referred to
Ergonomics: The Study of Work

DTIC Science & Technology

2000-01-01

Disease Name thumbs pain at the base of the thumbs twisting and gripping butchers , house- keepers, packers, seam- stresses, cutters fingers De...Quervain’s disease difficulty moving finger; snapping and jerking movements repeatedly using the index fingers meatpackers, poultry workers, carpenters...line workers rotator cuff tendinitis hands, wrists pain, swelling repetitive or forceful hand and wrist motions core making, poultry process- ing
Reducing Secondary Insults in Traumatic Brain Injury

DTIC Science & Technology

2015-03-01

from external stimuli ( vibration , noise ) and from acceleration and deceleration forces. During transport, Critical Care Air transport Team crews...provide excess noise and vibration during flight. Hearing protection for patients and flight crew is required to avoid damage. Vibration experi- enced...decelerative forces. In addition, the noise , vibration , and patient agitation associated with the tactical takeoff and land- ing of military cargo

Using Abstraction in Explicity Parallel Programs.

DTIC Science & Technology

1991-07-01

However, we only rely on sequential consistency of memory operations. includ- ing reads. writes and any synchronization primitives provided by the...explicit synchronization primitives . This demonstrates the practical power of sequentially consistent memory, as opposed to weaker models of memory that...a small set of synchronization primitives , all pro- cedures have non-waiting specifications. This is in contrast to richer process-oriented
Worldwide Report, Telecommunications Policy, Research and Development.

DTIC Science & Technology

1984-02-01

Bahrain, Bangladesh, Cuba, North Korea, Egypt, Ethiopia, Ghana, Indonesia, Iran, Jordan, Kuwait, Laos, Libya, Madagascar, Malaysia , Maldives...communication as in economic development, television and film banks could be built up. Each country could draw material of interest to it. "We have...personalities, includ- ing Prof. Yashpal, consultant to the Planning Commission, and film director Mrinal Sen at the plenary session. Technologies
Worldwide Report, Nuclear Development and Proliferation

DTIC Science & Technology

1984-05-14

PROLIFERATION IMC QUALITY: 19980729 081 FBIS FOREIGN BROADCAST INFORMATION SERVICE REPRODUCED BY NATIONAL TECHNICAL INFORMATION SERVICE U.S...Information Service , Springfield, Virginia 22161. In order- ing, it is recommended that the JPRS number, title, date and author, if applicable, of...Information Service , and are listed in the Monthly Catalog of U.S. Government Publications issued by the Superintendent of Documents, U.S. Government
Declassifying coverage. New guidance documents issued by the CMS may clarify the great unknown of Medicare coverage determination.

PubMed

Barr, Paul

2005-03-21

Heard of Section 731 of the Medicare Modernization Act? The provision, meant to clear up the generally murky and unwieldy Medicare reimbursement approval process, could quicken the national approval process for medical procedures and devices. The changes will create a more definable approach to OK'ing new technologies. "I like the idea of bringing more science to bear," says Richard Pico, left.
Army Communicator. Volume 35, Number 3, Fall 2010

DTIC Science & Technology

2010-01-01

Self - Healing Waveform extends squad communications Edric Thompson 44 5th Signal Command Implementing new...exciting because the network self heals its fragmented connectivity by leveraging other squad radios us- ing the waveform, said Mr. Eric Wil- liams...R&D Self - healing Waveform Rodney Smith (left), and Ted Krainski of C4ISR OTM set up radios as static nodes, representing
Maximize Your Teaching

ERIC Educational Resources Information Center

Cleaver, Samantha

2011-01-01

Here's an awesome thought! Teaching means a teacher's impact on students will last a lifetime. And despite the negatives one hears in the news, a 2010 ING Foundation poll found that 98 percent of adults believe a good teacher can "change the course of a child's life." This year, a teacher will affect every child in his/her class. Over the course…
Current Opinion on Catheter-based Hemorrhage Control in Trauma Patients

DTIC Science & Technology

2014-01-01

catheter-based interventions. Similar guidelines for competency/credentialing of practitioners to per- form endovascular stent grafting of the thoracic...practitioners to perform endovascular stent -grafting of the thoracic aorta. J Thorac Cardiovasc Surg. 2006;131: 530 532. 30. Rosenfield KM. Clinical...competence statement on carotid stenting : train- ing and credentialing for carotid stenting multispecialty consensus rec- ommendations. J Vasc Surg. 2005;41
The Real Rebalancing: American Diplomacy and the Tragedy of President Obama’s Foreign Policy

DTIC Science & Technology

2015-10-01

engagement” to its list of warfight- ing functions, along with mission command, move- ment and maneuver, intelligence , fires, sustainment, and protection...technologies, and foreign intelligence collection. Even earlier, see National Security Strategy, Washington, DC: The White House, August 1991, p. 8... Malnutrition , illiteracy and poverty put dangerous pressures on democratic institutions as hungry, uneducated or poorly 33 housed citizens are ripe for
Clinical Investigations Service.

DTIC Science & Technology

1979-09-30

79/42 (M79,O) The Incidence of Visual Motor Perceptual Problems in Persons with Traumatic Hand Injuries ...the Left Lower Lobe. Su-mJ.tted for publication. Youngberg JA: Seizures follw ing a shuntogram performed with diatrizoate meglumine. Accepted for...publication in Anesthesiology Copeland R. Tendon Transfers in the Cerebral Palsy Patient. Presented at the New Mexico Chapter Western Orthopaedic Assoc 1979
Japan Report, Science and Technology.

DTIC Science & Technology

1987-02-06

cyclodextrin, which consists of natural cyclic oligosaccharides . Recently, the author and co-workers have found that methylated CD works as an effective...industry as catalysts for the production of olefin derivatives. This is quite interesting, when we compare it with the shitasu process . Research on...lasers in machin- ing and medicine, particularly in semiconductor processing . According to the Optoelectronic Industry and Technology Development
The Management Information Needs of the Activity Level Comptroller within the Marine Corps.

DTIC Science & Technology

1983-03-01

authority, cost accounting , and maintaining plant property account records and inventory. 14 . ., Sections that are usually maintained within accounting ...disbursing divisions are timekeeping, payroll, cost and reports, inventory account - ing, military pay records, public voucher, fiscal and savings bond...units incurring the expenses. PRIME was developed as a disciplined and mechanized way, to directly identify accountable cost separate from allocated
Basewide Energy Study, Fort Wainwright Alaska: Volume 1-Executive Summary

DTIC Science & Technology

1982-04-01

more accurate condensate wiett?Ing. 2.2 ENERGY OSAGE ANALISIS 4 top~down anay2ts was mad" of FY’•0 ener;’ uxage’ t Fort wrtsvrigFnt. The spporiIonments...vice, at each receptacle cluster . It should be thermally sensitlve. rtdtcing through-put from 600 watts at -SOOT to0soer power at 100? outside air
L1-Based Approximations of PDEs and Applications

DTIC Science & Technology

2012-09-05

the analysis of the Navier-Stokes equations. The early versions of artificial vis- cosities being overly dissipative, the interest for these technique ...Guermond, and B. Popov. Stability analysis of explicit en- tropy viscosity methods for non-linear scalar conservation equations. Math. Comp., 2012... methods for solv- ing mathematical models of nonlinear phenomena such as nonlinear conservation laws, surface/image/data reconstruction problems
Wastewater Treatment Evaluation, Mather AFB, CA

DTIC Science & Technology

1974-06-01

conveyed to the treatment facility is provided with secondary (biological) treatment and chlorination followed by polish- ing lagoons prior to bang...comminutor. b. Primary sedimentation (clarifier). c. Biological oxidation by trickling filter. d. Secondary sedimentation (clarifier). e. Chlorination . f...the entrance to the chlorine contact chamber. Following chlorination , the wastewater flows to the wet well of the effluent lift station from
Novel single photon sources for new generation of quantum communications

DTIC Science & Technology

2017-06-13

be used as building blocks for quantum cryptography and quantum key distribution There were numerous important achievements for the projects in the...single photon sources that will be used as build- ing blocks for quantum cryptography and quantum key distribution There were numerous im- portant...and enable absolutely secured information transfer between distant nodes – key prerequisite for quantum cryptography . Experiment: the experimental
A Requirement Specification Language for AADL

DTIC Science & Technology

2016-06-01

008 | SOFTWARE ENGINEERING INSTITUTE | CARNEGIE MELLON UNIVERSITY Distribution Statement A: Approved for Public Release; Distribution is Unlimited...Copyright 2016 Carnegie Mellon University This material is based upon work funded and supported by the Department of Defense under Contract No...FA8721-05-C-0003 with Carnegie Mellon University for the operation of the Software Engineer- ing Institute, a federally funded research and development
Update of the Body Armour Purchase and Replacement Protocol

DTIC Science & Technology

2014-10-01

marized by t ty level (RQ escribes wha h a 95% perc ing plan rout ptance. For t 125 items a of 5.2%. T ts that are 5 es accepted a Typical Oper e OC...58 4.3.3 Operating Characteristic (OC) Curve...s Introduced ves for Sque rmour Purch breviations/a ed Armour T nsiderations ..................... ..................... with NIJ-010 glia C
Curcumin: a novel therapeutic for burn pain and wound healing

DTIC Science & Technology

2013-08-01

reduced side effects to treat both acute and chronic pain following burn injury. Novel biologic drugs [9], stem cells [10] and alternative medicine ...approaches including acupuncture, botanical medicine , massage and neuroreflexotherapy are some of the cost-effective and promis- ing complementary and...stay in the hospital; however, pain remains largely undercontrolled. Among the botanical medicines for burn treatments, one of the promising and
Proceedings of the USAF Structural Integrity Program Conference Held in 11-13 December 1990 in San Antonio, Texas

DTIC Science & Technology

1991-08-01

mill 3 dp Chromic Anodizing plus Polyurethane Fuel Coating 2 ep Sulfuric Acid Anodizing 1 Alloys other than aluminums require independent evaluation...generators for recircula- aluminum . During manufactur- tion. After peening, the ing, the iron is removed anodic coating and paint were prior to the...Growth Retardation in Aluminum Alloys . . 310 Quality Nondestructive Evaluation, and the ". .. IP’ Process
Whittier Narrows Flood Control Basin Historic Resources Survey,

DTIC Science & Technology

1976-10-15

crops; other spots yielded lettuce, cauliflower , and cabbage. Still other farm areas were devoted to growing flowers for seed. In a few places, where...gicai search’ing cculd begin o-n n p;, ears t rci., L-. evaidence now available) to be the, probabl e crigin a]- it <’ f 3e 1-1 i sion, as indicated

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