Nutrition and Child Growth and Development in Tunisia. Annual Progress Report, September 1, 1971--August 31, 1972.

ERIC Educational Resources Information Center

Young, Harben Boutourline

This annual report of the Yale Project describes the progress made on the nutrition and growth study of Tunisian children from September 1, 1971 through August 31, 1972. The report details: (1) the progress in analysis of the cross-sectional study data, which was completed as of June 30, 1972, and (2) the development of the present longitudinal…

3 CFR - Improving Energy Security, American Competitiveness and Job Creation, and Environmental...

Code of Federal Regulations, 2011 CFR

2011-01-01

... source of fossil fuel consumption and greenhouse gas pollution. I therefore request that the... annual progress in reducing transportation sector emissions and fossil fuel consumption consistent with... substantial annual progress in reducing transportation sector greenhouse gas emissions and fossil fuel...

FY2014 Fuel & Lubricant Technologies Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stork, Kevin

2016-02-01

Annual progress report for Fuel & Lubricant Technologies. The Fuel & Lubricant Technologies Program supports fuels and lubricants research and development (R&D) to provide vehicle manufacturers and users with cost-competitive options that enable high fuel economy with low emissions, and contribute to petroleum displacement.

76 FR 45234 - Information Collection; Submission for OMB Review, Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-28

... information collection request (ICR) entitled Annual Grantee Progress Report to the Office of Management and... through the use of appropriate automated, electronic, mechanical, or other technological collection... attached Annual Grantee Progress Report which will be used by grantees of the Corporation's AmeriCorps...

77 FR 1508 - Agency Information Collection Activities: Extension of a Currently Approved Collection; Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... DEPARTMENT OF JUSTICE [OMB Number 1122-0006] Agency Information Collection Activities: Extension... Budget, Office of Information and Regulatory Affairs, Attention Department of Justice Desk Officer... hour to complete a semi-annual progress report. The semi-annual progress report is divided into...

Annual Reports Regarding Progress in Developing a Dredged Material Management Plan for the Long Island Sound Region

EPA Pesticide Factsheets

The site designation for the Western and Central Long Island Sound disposal sites requires the completion of a Dredged Material Management Plan (DMMP) and EPA to conduct an annual review of progress toward completion of the DMMP.

77 FR 67668 - Agency Information Collection Activities; Extension of a Currently Approved Collection: Semi...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-13

... of a Currently Approved Collection: Semi-Annual Progress Report for the Sexual Assault Services...-Annual Progress Report for Grantees from the Sexual Assault Services Program--Grants to Culturally... sustainable sexual assault services provided by culturally specific organizations, which are uniquely situated...

Southeastern Community College Annual Progress Report, December 1995.

ERIC Educational Resources Information Center

Gardner, R. Gene

Presenting information on the status of Southeastern Community College (SCC), in Iowa, this annual progress report highlights basic institutional data, financial information, and improvements and planned changes of the college as of 1995. Part 1 presents basic data on SCC, including facility locations, assessed property valuation, district…

Progress in Scientific and Technical Communications, 1968 Annual Report.

ERIC Educational Resources Information Center

Federal Council for Science and Technology, Washington, DC. Committee on Scientific and Technical Information.

This sixth annual report describes progress achieved by the Federal Government in improving the communication of scientific and technical information to support and enhance national science and technology. Included in the report are details regarding the scientific and technical activities of individual Federal Agencies, such as the Atomic Energy…

76 FR 11277 - Agency Information Collection Activities: Extension of a Currently Approved Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-01

...- Annual Progress Report for Grantees From the Grants To Support Tribal Domestic Violence and Sexual...-Annual Progress Report for Grantees from the Grants to Support Tribal Domestic Violence and Sexual... development and operation of new or existing nonprofit tribal domestic violence and sexual assault coalitions...

78 FR 58557 - Agency Information Collection Activities; Extension of a Currently Approved Collection; Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-24

... DEPARTMENT OF JUSTICE [OMB Number 1122-0024] Agency Information Collection Activities; Extension... Office of Management and Budget, Office of Information and Regulatory Affairs, Attention Department of...) approximately one hour to complete a semi-annual progress report. The semi-annual progress report is divided...

77 FR 63339 - Agency Information Collection Activities; Extension of a Currently Approved Collection; Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

... DEPARTMENT OF JUSTICE [OMB Number 1122-0022] Agency Information Collection Activities; Extension..., Attention Department of Justice Desk Officer, Washington, DC 20503. Additionally, comments may be submitted...) approximately one hour to complete a semi-annual progress report. The semi-annual progress report is divided...

2014 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2014-11-01

The 2014 Annual Progress Report summarizes fiscal year 2014 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus.

PubMed

Gonzalez-Curiel, Irma; Castañeda-Delgado, Julio; Lopez-Lopez, Nallely; Araujo, Zaida; Hernandez-Pando, Rogelio; Gandara-Jasso, Benjamin; Macias-Segura, Noe; Enciso-Moreno, Antonio; Rivas-Santiago, Bruno

2011-08-01

Tuberculosis (TB) is one of the most important infectious diseases, causing 1.8 million deaths annually worldwide. This problem has increased because of the association with human immmunodeficiency virus and diabetes mellitus type 2, mainly in developing countries. In the past few years it has been highlighted the significance of antimicrobial peptides in the immunopathogenesis of TB ex vivo and in experimental models studies. In this study we analyzed the expression of CAMP, DEFA1, DEFB4, and DEFB103A in patients with latent TB and progressive TB with and without comorbidity with diabetes mellitus type 2. Antimicrobial peptide gene expression increased during progressive TB, which could be used as a biomarker for reactivation. By contrast, patients with diabetes mellitus type 2 have lower antimicrobial peptides gene expression, suggesting that the lack of its proper production in these patients contribute to enhance the risk for TB reactivation. Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

76 FR 45861 - Agency Information Collection Activities: New Collection; Semi-Annual Progress Report for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... Collection; Semi- Annual Progress Report for Grantees from the Children and Youth Exposed to Violence Program... Violence Against Women (OVW) will be submitting the following information collection request to the Office... Violence Program. (3) Agency form number, if any, and the applicable component of the Department of Justice...

76 FR 30389 - Agency Information Collection Activities: New collection Semi-Annual Progress Report for Grantees...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... incidences of sexual assault, domestic violence, dating violence, or stalking. (5) An estimate of the total... collection Semi- Annual Progress Report for Grantees from the Children and Youth Exposed to Violence Program... Violence Against Women (OVW) will be submitting the following information collection request to the Office...

2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The 2015 Annual Progress Report summarizes fiscal year 2015 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; and market transformation.

Mean annual attachment, bone level, and tooth loss: A systematic review.

PubMed

Needleman, Ian; Garcia, Raul; Gkranias, Nikos; Kirkwood, Keith L; Kocher, Thomas; Iorio, Anna Di; Moreno, Federico; Petrie, Aviva

2018-06-01

Rate of progression of periodontitis has been used to inform the design of classifications of periodontal diseases. However, the evidence underpinning this topic is unclear and no systematic review has yet been conducted. The focused question for this systematic review was: in adults, what is the progression of periodontitis in terms of clinical attachment loss, radiographic bone loss, and tooth loss? Highly sensitive electronic search was conducted for published data in MEDLINE, EMBASE, LILACS, and unpublished grey literature in OpenGrey up to February 2016. Reference lists of retrieved studies for full-text screening and reviews were hand-searched for potentially eligible studies. Prospective, longitudinal observational studies with follow-up of at least 12 months and presenting data on the primary outcome, change in clinical attachment level, in adults (age ≥18 years). Secondary outcomes, tooth loss and bone level change, were only assessed in studies reporting the primary outcome. Studies investigating specific disease populations or only on treated periodontitis patients were excluded. Risk of bias and methodology were assessed using the Newcastle-Ottawa Scale with two additional questions on security of outcome assessment. Studies were pooled by abstracting or estimating mean annual attachment or bone level change and annual tooth loss. Random effects meta-analysis was conducted with investigation of effect of potential modifiers where possible. A total 11,482 records were screened for eligibility; 33 publications of 16 original studies reporting on more than 8,600 participants were finally included as eligible for the review. The studies represented populations from both developing and developed economies. Mean annual attachment loss was 0.1 mm per year (95% CI 0.068, 0.132; I 2  = 99%) and mean annual tooth loss was 0.2 teeth per year (95% CI 0.10, 0.33; I 2  = 94%). Observational analysis of highest and lowest mean attachment change quintiles suggested substantial differences between groups with minimal annual change in the lowest quintile and an average deterioration of 0.45 mm mean attachment loss per year in the highest group. This value increased to 0.6 mm per year with periodontitis alone. There was surprisingly little effect of age or gender on attachment level change. Geographic location, however, was associated with more than three times higher mean annual attachment loss in Sri Lanka and China (0.20 mm, 95% CI 0.15, 0.27; I 2  = 83%) vs North America and Europe (0.056 mm, 95% CI 0.025, 0.087; I 2  = 99%) P < 0.001. There were a limited number of studies (N = 16), high variability of design in key study components (sampling frames, included ages, data analyses), and high statistical heterogeneity that could not be explained. Within the limitations of the research, the data show that mean annual attachment level change varies considerably both within and between populations. Overall, the evidence does not support or refute the differentiation between forms of periodontal diseases based upon progression of attachment level change. © 2018 American Academy of Periodontology and European Federation of Periodontology.

Annual changes in radiographic indices of the spine in cerebral palsy patients.

PubMed

Lee, Seung Yeol; Chung, Chin Youb; Lee, Kyoung Min; Kwon, Soon-Sun; Cho, Kyu-Jung; Park, Moon Seok

2016-03-01

We estimated the annual changes in radiographic indices of the spine in cerebral palsy (CP) patients and analyzed the factors that influence its progression rate. We included CP patients who had undergone whole-spine radiography more than twice and were followed for at least 1 year. The scoliosis Cobb angle, coronal balance, apical vertebral translation, apical rotation, and pelvic obliquity were measured on anteroposterior (AP) radiographs; thoracic kyphosis and lumbar lordosis angles, and sagittal balance was measured on lateral radiographs; and migration percentage was measured on AP hip radiographs to determine hip instability. For each gross motor function classification system (GMFCS) level, the Cobb angles, apical vertebral translation, coronal and sagittal balance, and pelvic obliquity were adjusted by multiple factors with a linear mixed model. A total of 184 patients (774 radiographs) were included in this study. There was no significant annual change in scoliosis Cobb, thoracic kyphosis, and lumbar lordosis angles in the GMFCS level I-II and III groups. In the GMFCS level IV-V group, there was an annual increase of 3.4° in the scoliosis Cobb angle (p = 0.020). The thoracic kyphosis angle increased by 2.2° (p = 0.018) annually in the GMFCS level IV-V group. Apical vertebral translation increased by 5.4 mm (p = 0.029) annually in the GMFCS level IV-V group. Progression of coronal and sagittal balance and pelvic obliquity with aging were not statistically significant. Sex, hip instability, hip surgery, and triradiate cartilage did not affect the progression of scoliosis and the balance of the spine and pelvis. The scoliosis Cobb angle, thoracic kyphosis angle, and apical vertebral translation in the GMFCS level IV-V CP patients progressed with age. These findings can predict radiographic progression of scoliosis in CP patients.

2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The 2016 Annual Progress Report summarizes fiscal year 2016 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; market transformation; and Small Business Innovation Research projects.

Reporting Florida's Annual Measurable Objectives (AMOs) in Compliance with ESEA Flexibility Requirements: Guide to Calculations for 2013-14

ERIC Educational Resources Information Center

Florida Department of Education, 2014

2014-01-01

This Annual Measurable Objective (AMO) is designed to keep Florida moving forward toward national and international competitiveness. Florida will compare its National Assessment of Educational Progress (NAEP) scores to those of the top five states and its Trends in International Mathematics and Science Study (TIMSS), Progress in International…

Annual Progress Report of the Coastal Bend Migrant Council Health Project, San Patricio Migrant Health Center (Texas), 1973-1974.

ERIC Educational Resources Information Center

Coastal Bend Migrant Council, Mathis, TX. San Patricio Migrant Health Center.

The annual medical progress report covers migrant health services in San Patricio County, Texas, from February 1, 1973 to January 31, 1974. The report discusses: staff, administration, cardiology, dental services, health services, medical services, outreach and environmental health services, prescription services, registration and identification,…

FLORIDA MIGRANT HEALTH PROJECT. FOURTH ANNUAL PROGRESS REPORT, 1966-1967.

ERIC Educational Resources Information Center

Florida State Board of Health, Jacksonville.

THE FOURTH ANNUAL PROGRESS REPORT OF THE FLORIDA MIGRANT HEALTH PROJECT INDICATES THAT IN 1966-67 THERE WAS AN APPRECIABLE INCREASE IN THE AMOUNT AND VARIETY OF MIGRANT HEALTH SERVICES RENDERED, THE NUMBER OF MIGRANTS CONTACTED, AND THE ACTIVITIES PERFORMED BY PROJECT PERSONNEL. MIGRANT HEALTH SERVICE REFERRALS INCREASED BY 1,222 OVER THE SAME…

Compilation of 1989 annual reports of the Navy ELF Communications System Ecological Monitoring Program. Volume 2. tabs C-F. Annual progress report, Jan-Dec 89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-08-01

This is the eighth compilation of annual reports for the Navy's ELF Communications Systems Ecological Monitoring Program. The reports document the progress of eight studies performed during 1989 near the Naval Radio Transmitting Facility -- Republic, Michigan. The purpose of the monitoring is to determine whether electromagnetic fields produced by the ELF Communications System will affect resident biota or their ecological relationships. Soil Amoeba: Arthropoda and Earthworms: Pollinating Insects: Small Mammals and Nesting Birds.

Genetic Variation in Dopamine Pathways Differentially Associated with Smoking Progression in Adolescence

ERIC Educational Resources Information Center

Laucht, Manfred; Becker, Katja; Frank, Josef; Schmidt, Martin H.; Esser, Gunter; Treutlein, Jens; Skowronek, Markus H.; Schumann, Gunter

2008-01-01

A study examines whether genetic variation in dopamine pathways differentially associate with smoking progression in adolescence. Results indicate the influence of specific dopamine genes in different stages of smoking progression in adolescents.

34 CFR 361.29 - Statewide assessment; annual estimates; annual State goals and priorities; strategies; and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Statewide assessment; annual estimates; annual State goals and priorities; strategies; and progress reports. 361.29 Section 361.29 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE...

34 CFR 361.29 - Statewide assessment; annual estimates; annual State goals and priorities; strategies; and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Statewide assessment; annual estimates; annual State goals and priorities; strategies; and progress reports. 361.29 Section 361.29 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE...

Statewide Report Card: An Annual Report to the Legislature on Oregon Public Schools, 2013-2014

ERIC Educational Resources Information Center

Oregon Department of Education, 2014

2014-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Statewide Report Card: An Annual Report to the Legislature on Oregon Public Schools, 2011-2012

ERIC Educational Resources Information Center

Oregon Department of Education, 2012

2012-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Annual Progress Report - Fiscal Year 1982

DTIC Science & Technology

1982-10-01

activity . A published method developed in our laboratory for determining tne antibacterial activity of mouse peritoneal phagocytes in vivo (1) has been...EDITOR’S NOTE This FY 1982 Annual Progress report is a general review of research activities of the U. S. Army Medical Research Institute of Infectious...years earlier. Passive immunization, active immunization using killed or living attenuated whole agent, or immunization with sub-unit antigens achieved

Statewide Report Card: An Annual Report to the Legislature on Oregon Public Schools; 2015-2016

ERIC Educational Resources Information Center

Oregon Department of Education, 2016

2016-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Pathogenesis of Salmonellosis: Salmonella Exotoxins

DTIC Science & Technology

1982-03-08

membrane-as3ociated enterotowin produced by S. enteritidis and by S. typhimurium ; however they could find no similarities between their Salmonella ...AD. . 0 REPORT NUJMBER 1 Pathogenesis of Salmoneiliosis: Salmonella Exotoxins Annual Progress Report (12/1/77-9/1/78) Johnny W. Peterson. Ph.D. March...TYPE OF REPORT & PERIOD COVEREOD",- Uathogenesis of ,Salmonellosils: Salmonella Annual Progress Report Exotoxins 12/T/77 9/1/78 C. PERFORMCNG ORG

An Annual Report to the Legislature on Oregon Public Schools. Oregon Statewide Report Card. 2014-2015

ERIC Educational Resources Information Center

Oregon Department of Education, 2015

2015-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

76 FR 65184 - Proposed Information Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-20

... Corporation is soliciting comments concerning its proposed Nonprofit Capacity Building Program Progress Report. The Progress Report consists of two parts: A Progress Report Narrative and a Performance Measurement Reporting Workbook. The Progress Report is completed semi-annually by Nonprofit Capacity Building Grantees...

Baseline predictors of aortic stiffness progression among multi-ethnic Asians with type 2 diabetes.

PubMed

Moh, Mei Chung; Sum, Chee Fang; Tavintharan, Subramaniam; Ang, Keven; Lee, Simon Biing Ming; Tang, Wern Ee; Lim, Su Chi

2017-05-01

This 3-year prospective study aimed to identify baseline parameters that predicted the progression of carotid-femoral pulse wave velocity (cf-PWV), which was used to evaluate aortic stiffness, among Singapore's multi-ethnic Asians with type 2 diabetes (T2DM). The cf-PWV was measured by the gold-standard tonometry method in 994 T2DM subjects at baseline and follow-up. The annual rate of cf-PWV change was calculated, and individuals above the 90 th percentile with rate≥1.42 m/s per year were regarded as rapid progressors (n = 104). In a subgroup analysis of subjects with normal cf-PWV at 1 st visit (n = 611), incident aortic stiffness was defined as follow-up cf-PWV≥10 m/s (n = 188). The total cohort (mean age:57 ± 10 years; 53.4% Chinese, 20.4% Malay, 22.9% Indian, 3.2% 'Others') displayed a median annual cf-PWV progression rate of 0.2 m/s. Adjusted multivariate regression analyses showed that baseline age, cf-PWV and body mass index (BMI) constantly predicted follow-up cf-PWV, annual cf-PWV progression rate, rapid cf-PWV progression, and incident aortic stiffness. Paradoxically, lower baseline cf-PWV was associated with elevated annual cf-PWV progression rate and rapid progressors. This inverse relationship remained significant across ethnicities after ethnic stratification. Higher BMI independently predicted cf-PWV progression in Chinese and Indians, but not in Malay and 'Others' ethnic groups. Increased age was a significant predictor in Chinese and 'Others' ethnicities. We demonstrated that baseline BMI is a modifiable independent risk factor of cf-PWV progression and incident aortic stiffness. Therefore, better obesity management may impede aortic stiffness in Singapore's T2DM patients, especially in the Chinese and Indians. Copyright © 2017. Published by Elsevier B.V.

Longitudinal analysis of progression in glaucoma using spectral-domain optical coherence tomography.

PubMed

Wessel, Julia M; Horn, Folkert K; Tornow, Ralf P; Schmid, Matthias; Mardin, Christian Y; Kruse, Friedrich E; Juenemann, Anselm G; Laemmer, Robert

2013-05-01

To compare the longitudinal loss of RNFL thickness measurements by SD-OCT in healthy individuals and glaucoma patients with or without progression concerning optic disc morphology. A total of 62 eyes, comprising 38 glaucomatous eyes with open angle glaucoma and 24 healthy controls, were included in the study (Erlangen Glaucoma Registry, NTC00494923). All patients were investigated annually over a period of 3 years by Spectralis SD-OCT measuring peripapillary RNFL thickness. By masked comparative analysis of photographs, the eyes were classified into nonprogressive and progressive glaucoma cases. Longitudinal loss of RNFL thickness was compared with morphological changes of optic disc morphology. Mixed model analysis of annual OCT scans revealed an estimated annual decrease of the RNFL thickness by 2.12 μm in glaucoma eyes with progression, whereas glaucoma eyes without progression in optic disc morphology lost 1.18 μm per year in RNFL thickness (P = 0.002). The rate of change in healthy eyes was 0.60 μm and thereby also significantly lower than in glaucoma eyes with progression (P < 0.001). The intrasession variability of three successive measurements without head repositioning was 1.5 ± 0.7 μm. The loss of mean RNFL thickness exceeded the intrasession variability in 60% of nonprogressive eyes, and in 85% of progressive eyes after 3 years. LONGITUDINAL MEASUREMENTS OF RNFL THICKNESS USING SD-OCT SHOW A MORE PRONOUNCED REDUCTION OF RNFL THICKNESS IN PATIENTS WITH PROGRESSION COMPARED WITH PATIENTS WITHOUT PROGRESSION IN GLAUCOMATOUS OPTIC DISC CHANGES. (www.clinicaltrials.gov number, NTC00494923.).

2016 Nebraska Higher Education Progress Report

ERIC Educational Resources Information Center

Nebraska's Coordinating Commission for Postsecondary Education, 2016

2016-01-01

The 2016 Nebraska Higher Education Progress Report is the 12th annual progress report designed to provide the Nebraska Legislature with comparative statistics to monitor and evaluate progress toward achieving three key priorities for Nebraska's postsecondary education system. These priorities were developed by the 2003 LR 174 Higher Education Task…

Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C.

PubMed

Leite, Andréa G B; Duarte, Maria Irma S; Mendes-Correa, Maria Cássia

2015-01-01

Several studies have demonstrated that HIV/hepatitis C virus (HCV)-coinfected patients experience more rapid fibrosis progression. In this study, to estimate the annual rate of direct liver fibrosis progression, we used analyses of paired biopsy samples from HIV/HCV-coinfected patients without prior treatment of hepatitis and assessed the possible association of fibrosis progression with certain clinical variables. We evaluated 30 HIV/HCV-coinfected patients, with no history of prior treatment of hepatitis C, who underwent paired liver biopsies. All patients were under antiretroviral therapy at first and second biopsies. The average annual progression rate was 0.13 fibrosis unit/year, with 36.7% of patients defined as progressors. Liver fibrosis progression was associated with alanine aminotransferase (ALT; P < .001) and aspartate aminotransferase (AST; P < .0340) levels over 3 times the upper limit of normal present at first biopsy. Elevated ALT and AST levels appear to be associated with more accelerated liver fibrosis progression among HIV/HCV-coinfected patients. © The Author(s) 2015.

Vocational Education--A Decade of Progress. 10th Annual Report of the Advisory Council for Technical-Vocational Education in Texas to the State Board for Vocational Education.

ERIC Educational Resources Information Center

Texas Advisory Council for Technical - Vocational Education, Austin.

Assessment of the present status of vocational education in Texas and recommended priorities for the future constitute this annual report. Part 1 documents the progress of the 1970s and lists 15 challenges for vocational education in the 1980s, including application of meaningful evaluation procedures and careful program planning to maximize cost…

Annual Research Progress Report, Fiscal Year 1980

DTIC Science & Technology

1980-10-01

AITE -sd Subtitle) 3. TYPE OF REPORT & PERIOD COVERED 4UAL RESEARCH pROGRESS REPORT ____________ANNUAL - FY 80 S- -- 4. PERFORMING ORG. REPORT NUNSER 7...AUHON) 4F e. CONTRACT OR GRANT NUMBER(e)’ JAMES DERSON, JR , M.D. 10. PERFORMING ORGANIZATION NAME AND ADDRESS 10- PROGRAM ELEMENT, PROJECT, TASK...and DOD) regulations governing human, animal and even in vitro research, the declining number of academic physicians serving as role models and

Five-Year Progression of Refractive Errors and Incidence of Myopia in School-Aged Children in Western China

PubMed Central

Zhou, Wen-Jun; Zhang, Yong-Ye; Li, Hua; Wu, Yu-Fei; Xu, Ji; Lv, Sha; Li, Ge; Liu, Shi-Chun; Song, Sheng-Fang

2016-01-01

Background To determine the change in refractive error and the incidence of myopia among school-aged children in the Yongchuan District of Chongqing City, Western China. Methods A population-based cross-sectional survey was initially conducted in 2006 among 3070 children aged 6 to 15 years. A longitudinal follow-up study was then conducted 5 years later between November 2011 and March 2012. Refractive error was measured under cycloplegia with autorefraction. Age, sex, and baseline refractive error were evaluated as risk factors for progression of refractive error and incidence of myopia. Results Longitudinal data were available for 1858 children (60.5%). The cumulative mean change in refractive error was −2.21 (standard deviation [SD], 1.87) diopters (D) for the entire study population, with an annual progression of refraction in a myopic direction of −0.43 D. Myopic progression of refractive error was associated with younger age, female sex, and higher myopic or hyperopic refractive error at baseline. The cumulative incidence of myopia, defined as a spherical equivalent refractive error of −0.50 D or more, among initial emmetropes and hyperopes was 54.9% (95% confidence interval [CI], 45.2%–63.5%), with an annual incidence of 10.6% (95% CI, 8.7%–13.1%). Myopia was found more likely to happen in female and older children. Conclusions In Western China, both myopic progression and incidence of myopia were higher than those of children from most other locations in China and from the European Caucasian population. Compared with a previous study in China, there was a relative increase in annual myopia progression and annual myopia incidence, a finding which is consistent with the increasing trend on prevalence of myopia in China. PMID:26875599

Five-Year Progression of Refractive Errors and Incidence of Myopia in School-Aged Children in Western China.

PubMed

Zhou, Wen-Jun; Zhang, Yong-Ye; Li, Hua; Wu, Yu-Fei; Xu, Ji; Lv, Sha; Li, Ge; Liu, Shi-Chun; Song, Sheng-Fang

2016-07-05

To determine the change in refractive error and the incidence of myopia among school-aged children in the Yongchuan District of Chongqing City, Western China. A population-based cross-sectional survey was initially conducted in 2006 among 3070 children aged 6 to 15 years. A longitudinal follow-up study was then conducted 5 years later between November 2011 and March 2012. Refractive error was measured under cycloplegia with autorefraction. Age, sex, and baseline refractive error were evaluated as risk factors for progression of refractive error and incidence of myopia. Longitudinal data were available for 1858 children (60.5%). The cumulative mean change in refractive error was -2.21 (standard deviation [SD], 1.87) diopters (D) for the entire study population, with an annual progression of refraction in a myopic direction of -0.43 D. Myopic progression of refractive error was associated with younger age, female sex, and higher myopic or hyperopic refractive error at baseline. The cumulative incidence of myopia, defined as a spherical equivalent refractive error of -0.50 D or more, among initial emmetropes and hyperopes was 54.9% (95% confidence interval [CI], 45.2%-63.5%), with an annual incidence of 10.6% (95% CI, 8.7%-13.1%). Myopia was found more likely to happen in female and older children. In Western China, both myopic progression and incidence of myopia were higher than those of children from most other locations in China and from the European Caucasian population. Compared with a previous study in China, there was a relative increase in annual myopia progression and annual myopia incidence, a finding which is consistent with the increasing trend on prevalence of myopia in China.

Progress Report

EPA Pesticide Factsheets

2018-05-15

This report summarizes the annual progress of EPA’s Clean Air Markets Programs such as the Acid Rain Program (ARP) and the Cross-State Air Pollution Rule (CSAPR). EPA systematically collects data on emissions, compliance, and environmental effects, these data are highlighted in our Progress Reports.

Progress Report

EPA Pesticide Factsheets

2018-05-16

This report summarizes the annual progress of EPA’s Clean Air Markets Programs such as the Acid Rain Program (ARP) and the Cross-State Air Pollution Rule (CSAPR). EPA systematically collects data on emissions, compliance, and environmental effects, these data are highlighted in our Progress Reports.

Use of a Progress Monitoring System to Enable Teachers to Differentiate Mathematics Instruction

ERIC Educational Resources Information Center

Ysseldyke, Jim; Tardrew, Steve

2007-01-01

We explored how a progress monitoring and instructional management system can be used to help educators differentiate instruction and meet the wide-ranging learning needs of their increasingly diverse classrooms. We compared classrooms in 24 states that used a curriculum-based progress monitoring and instructional management system, Accelerated…

Health Transportation Working Group 2016 Annual Report

DOT National Transportation Integrated Search

2017-06-30

The Health in Transportation Working Group 2016 Annual Report provides an overview of the Working Groups activities and accomplishments in 2016, summarizes other USDOT health-related accomplishments, and documents its progress toward the recommend...

Fluctuations of cambial activity in relation to precipitation result in annual rings and intra-annual growth zones of xylem and phloem in teak (Tectona grandis) in Ivory Coast

PubMed Central

Dié, Agathe; Kitin, Peter; Kouamé, François N'Guessan; Van den Bulcke, Jan; Van Acker, Joris; Beeckman, Hans

2012-01-01

Background and Aims Teak forms xylem rings that potentially carry records of carbon sequestration and climate in the tropics. These records are only useful when the structural variations of tree rings and their periodicity of formation are known. Methods The seasonality of ring formation in mature teak trees was examined via correlative analysis of cambial activity, xylem and phloem formation, and climate throughout 1·5 years. Xylem and phloem differentiation were visualized by light microscopy and scanning electron microscopy. Key Results A 3 month dry season resulted in semi-deciduousness, cambial dormancy and formation of annual xylem growth rings (AXGRs). Intra-annual xylem and phloem growth was characterized by variable intensity. Morphometric features of cambium such as cambium thickness and differentiating xylem layers were positively correlated. Cambium thickness was strongly correlated with monthly rainfall (R2 = 0·7535). In all sampled trees, xylem growth zones (XGZs) were formed within the AXGRs during the seasonal development of new foliage. When trees achieved full leaf, the xylem in the new XGZs appeared completely differentiated and functional for water transport. Two phloem growth rings were formed in one growing season. Conclusions The seasonal formation pattern and microstructure of teak xylem suggest that AXGRs and XGZs can be used as proxies for analyses of the tree history and climate at annual and intra-annual resolution. PMID:22805529

Coordination of Myeloid Differentiation with Reduced Cell Cycle Progression by PU.1 Induction of MicroRNAs Targeting Cell Cycle Regulators and Lipid Anabolism.

PubMed

Solomon, Lauren A; Podder, Shreya; He, Jessica; Jackson-Chornenki, Nicholas L; Gibson, Kristen; Ziliotto, Rachel G; Rhee, Jess; DeKoter, Rodney P

2017-05-15

During macrophage development, myeloid progenitor cells undergo terminal differentiation coordinated with reduced cell cycle progression. Differentiation of macrophages from myeloid progenitors is accompanied by increased expression of the E26 transformation-specific transcription factor PU.1. Reduced PU.1 expression leads to increased proliferation and impaired differentiation of myeloid progenitor cells. It is not understood how PU.1 coordinates macrophage differentiation with reduced cell cycle progression. In this study, we utilized cultured PU.1-inducible myeloid cells to perform genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) analysis coupled with gene expression analysis to determine targets of PU.1 that may be involved in regulating cell cycle progression. We found that genes encoding cell cycle regulators and enzymes involved in lipid anabolism were directly and inducibly bound by PU.1 although their steady-state mRNA transcript levels were reduced. Inhibition of lipid anabolism was sufficient to reduce cell cycle progression in these cells. Induction of PU.1 reduced expression of E2f1 , an important activator of genes involved in cell cycle and lipid anabolism, indirectly through microRNA 223. Next-generation sequencing identified microRNAs validated as targeting cell cycle and lipid anabolism for downregulation. These results suggest that PU.1 coordinates cell cycle progression with differentiation through induction of microRNAs targeting cell cycle regulators and lipid anabolism. Copyright © 2017 American Society for Microbiology.

Annual Progress Report, 1975. Southern Rural Development Center, Mississippi State University. SRDC Series Publication No. 10.

ERIC Educational Resources Information Center

Southern Rural Development Center, State College, MS.

Included in this second annual report on the Southern Rural Development Center's (SRDC) 1974-75 plan of work are data re: orientation visits; regional workshops; technical consultants; liaison with regional agencies and organizations; information dissemination; annual evaluation; functional networks in the areas of land use issues, citizen…

Genetic progress in oat associated with fungicide use in Rio Grande do Sul, Brazil.

PubMed

Follmann, D N; Cargnelutti Filho, A; Lúcio, A D; de Souza, V Q; Caraffa, M; Wartha, C A

2016-12-19

The State of Rio Grande do Sul (RS) is the largest producer of oat in Brazil with the aid of consolidated breeding programs, which are constantly releasing new cultivars. The main objectives of this study were to: 1) evaluate the annual genetic progress in grain yield and hectoliter weight of the oat cultivars in RS, with and without fungicide use on aerial parts of plants; and 2) evaluate the efficiency of oat breeding programs in introducing disease-resistant genes in the released cultivars through network yield trials conducted with and without fungicide use on aerial plant parts. The data on grain yield and hectoliter weight were obtained from 89 competition field trials of oat cultivars carried out from 2007 to 2014 in nine municipalities of RS. Of the total 89 trials, 44 were carried out with fungicide application on aerial plant parts and 45 were carried out without fungicide application. The annual genetic progress in oat cultivars was studied using the methodology proposed by Vencovsky (1988). The annual genetic progress in oat grain yield was 1.02% with fungicide use and 4.02% without fungicide use during the eight-year study period in RS. The annual genetic progress with respect to the hectoliter weight was 0.08% for trials with fungicide use and 0.71% for trials without fungicide use. Performing network yield trials with and without fungicide use on the aerial plants parts is a feasible method to evaluate the efficiency of oat breeding programs in introducing disease-resistant genes in the released cultivars.

GFORCE-PD still going strong in 2016

PubMed Central

Parmar, Malin; Takahashi, Jun; Studer, Lorenz; Barker, Roger A

2017-01-01

In 2014, a new initiative was undertaken by groups working on plans for the transplantation of stem-cell-based derived dopaminergic neurons for treating Parkinson’s disease patients. This GForce-PD group held its annual meeting on 18–19 April 2016 in Chicago at Rush University to discuss their progress and the challenges that the translation of this experimental therapy still faces. Over 2 days, the key issues were discussed around the cell lines that will be used, the differentiation protocols, preclinical testing, GMP-adaptation, and cell manufacturing to allow first in human clinical trials, which are anticipated to start in 2017–2018. GForce-PD members also discussed how they can improve outreach and be of better service to the Parkinson's disease (PD) community and help them to make the best possible decisions when pursuing stem cell treatments.

High Level of Chemokine CCL18 Is Associated With Pulmonary Function Deterioration, Lung Fibrosis Progression, and Reduced Survival in Systemic Sclerosis.

PubMed

Hoffmann-Vold, Anna-Maria; Tennøe, Anders Heiervang; Garen, Torhild; Midtvedt, Øyvind; Abraityte, Aurelija; Aaløkken, Trond Mogens; Lund, May Britt; Brunborg, Cathrine; Aukrust, Pål; Ueland, Thor; Molberg, Øyvind

2016-08-01

Markers for early identification of progressive interstitial lung disease (ILD) in systemic sclerosis (SSc) are in demand. Chemokine CCL18, which has been linked to pulmonary inflammation, is an interesting candidate, but data have not been consistent. We aimed to assess CCL18 levels in a large, prospective, unselected SSc cohort with longitudinal, paired data sets on pulmonary function and lung fibrosis. Sera from the Oslo University Hospital SSc cohort (n = 298) and healthy control subjects (n = 100) were analyzed for CCL18 by enzyme immunoassay. High CCL18 (>53 ng/mL) was defined using the mean value plus 2 SD in sera obtained from healthy control subjects as the cutoff. High serum CCL18 was identified in 35% (105 of 298). Annual decline in FVC differed significantly between high and low CCL18 subsets (13.3% and 4.7%; P = .016), as did the annual progression rate of lung fibrosis (0.9% [SD, 2.9] and 0.2% [SD, 1.9]). Highest rates of annual FVC decline > 10% (21%) and annual fibrosis progression (1.2%) were seen in patients with high CCL18 and early disease (< 3 years). In multivariate analyses, CCL18 was associated with annual FVC decline > 10% (OR, 1.1; 95% CI, 1.01-1.11) and FVC < 70% at follow-up (OR, 3.1; 95% CI, 1.08-8.83). Survival analyses showed that patients with high CCL18 had reduced 5- and 10-year cumulative survival compared with patients with low CCL18 (85% and 74%, compared with 97% and 89%, respectively; P = .001). The results from this prospective cohort reinforce the notion that high CCL18 may serve as a marker for early identification of progressive ILD in SSc. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

The relationships between chemical and genetic differentiation and environmental factors across the distribution of Erigeron breviscapus (Asteraceae).

PubMed

Li, Xiang; Peng, Li-yan; Zhang, Shu-dong; Zhao, Qin-shi; Yi, Ting-shuang

2013-01-01

Erigeron breviscapus (Vant.) Hand.-Mazz. is an important, widely used Chinese herb with scutellarin, 1,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid and erigoster B being its major active compounds. We aimed to resolve the influence of biotic and abiotic factors on the concentrations of these compounds and to determine appropriate cultivation methods to improve the yields of the four compounds in this herb. In order to detect the major genetic and natural environmental factors affecting the yields of these four compounds, we applied AFLP markers to investigate the population genetic differentiation and HPLC to measure the concentrations of four major active compounds among 23 wild populations which were located across almost the entire distribution of this species in China. The meteorological data including annual average temperature, annual average precipitation and annual average hours of sunshine were collected. The relationships among the concentrations of four compounds and environmental factors and genetic differentiation were studied. Low intraspecific genetic differentiation is detected, and there is no obvious correlation between the genetic differentiation and the contents of the chemical compounds. We investigated the correlation between the concentrationsof four compounds (scutellarin, 1,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid and erigoster B) and environmental factors. Concentrations of two compounds (1,5-dicaffeoylquinic acid and 3,5-dicaffeoylquinic acid) were correlated with environmental factors. The concentration of 1,5-dicaffeoylquinic acid is positively correlated with latitude, and is negatively correlated with the annual average temperature. The concentration of 3,5-dicaffeoylquinic acid is positively correlated with annual average precipitation. Therefore, changing cultivation conditions may significantly improve the yields of these two compounds. We found the concentration of scutellarin positively correlated with that of erigoster B and 3,5-dicaffeoylquinic acid, respectively. We inferred that the synthesis of these two pairs of compounds may share similar triggering mechanism as they synthesized in a common pathway.

Progress

Cancer.gov

Through its Annual Report to the Nation and other reports and publications, the National Cancer Institute – leader of the National Cancer Program – marks the progress that’s been made by the cancer research community.

34 CFR 200.50 - SEA review of LEA progress.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false SEA review of LEA progress. 200.50 Section 200.50... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.50 SEA review of LEA progress. (a) State review. (1) An SEA must annually review the progress of each LEA in its State...

34 CFR 200.50 - SEA review of LEA progress.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false SEA review of LEA progress. 200.50 Section 200.50... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.50 SEA review of LEA progress. (a) State review. (1) An SEA must annually review the progress of each LEA in its State...

34 CFR 200.50 - SEA review of LEA progress.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false SEA review of LEA progress. 200.50 Section 200.50... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.50 SEA review of LEA progress. (a) State review. (1) An SEA must annually review the progress of each LEA in its State...

34 CFR 200.50 - SEA review of LEA progress.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false SEA review of LEA progress. 200.50 Section 200.50... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.50 SEA review of LEA progress. (a) State review. (1) An SEA must annually review the progress of each LEA in its State...

34 CFR 200.50 - SEA review of LEA progress.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false SEA review of LEA progress. 200.50 Section 200.50... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.50 SEA review of LEA progress. (a) State review. (1) An SEA must annually review the progress of each LEA in its State...

Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinga, K.R.

Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base.

Annual Progress Report (17th) and 1992-97 Renewal Proposal Interactive Graphics for Molecular Studies

DTIC Science & Technology

1991-01-24

Molecular Graphics, vol. 6, No. 4 (Dec. 1988), p. 223. Turk, Greg, "Interactive Collision Detection for Molecular Graphics," M.S. thesis , UNC-Chapel Hill...Problem," Master’s thesis , UNC Department of Computer Science Technical Report #TR87-013, May 1987. Pique, ME., "Technical Trends in Molecular Graphics...AD-A236 598 Seventeenth Annual Progress Report and 1992-97 Renewal Proposal Interactive Graphics for Molecular Studies TR91-020 January 24, 1991 red

Compilation of 1986 annual reports of the Navy ELF (extremely low frequency) communications system ecological-monitoring program. Volume 2. Tabs D-G. Annual progress report, January-December 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-07-01

The U.S. Navy is conducting a long-term program to monitor for possible effects from the operation of its Extremely Low Frequency (ELF) Communications System to resident biota and their ecological relationships. This report documents progress of the following studies: Soil Amoeba; Soil and Litter Arthropoda and Earthworm Studies; Biological Studies on Pollinating insects: Megachilid Bees; and Small Vertebrates: Small Mammals and Nesting Birds.

33rd Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2011

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services, US Department of Education, 2014

2014-01-01

This is the 33rd Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2011. Section 664(d) of the "Individuals with Disabilities Education Act" ("IDEA"), as reauthorized in 2004, requires that the Department of Education report annually on the progress made toward the…

Health in Transportation Working Group 2015 Annual Report

DOT National Transportation Integrated Search

2016-06-30

The Health in Transportation Working Group 2015 Annual Report provides an overview of the Working Groups activities and accomplishments : in 2015, summarizes other U.S. DOT health-related accomplishments, and documents its progress toward the reco...

Influence of indoor and outdoor activities on progression of myopia during puberty.

PubMed

Öner, Veysi; Bulut, Asker; Oruç, Yavuz; Özgür, Gökhan

2016-02-01

The purpose of this study was to investigate whether time spent on indoor and outdoor activities or the other possible risk factors including age, gender, parental history, and initial refraction was associated with progression of myopia, during puberty. Fifty eyes of 50 myopic children aged 9-14 years were enrolled in the study. The parents were interviewed to determine the amounts of time in hours per day spent on reading and writing, using computer, watching TV, and outdoor activities (i.e., sports, games, or being outdoor with no activities) on an average day. The annual myopia progression rate (diopters per year) was calculated for each subject and was used in the statistical analyses. The mean initial age of the subjects was 10.9 ± 1.5 (ranging from 9 to 14) years. The mean follow-up period was 33.3 ± 10.3 (ranging from 17 to 55) months. There was a significant increase in the mean myopia value of the subjects after follow-up period (p < 0.001). The mean daily time spent on reading and writing and initial refraction value were independently associated with annual myopic progression rate. On the other hand, age, gender, parental myopia, and the mean daily times spent on computer use, watching TV, and outdoor activities had no correlations with annual myopia progression rate. The present study showed that myopia progression was associated with time spent on reading and writing and initial refraction value, during puberty. However, myopia progression was not associated with parental myopia, age, gender, and daily times spent on using computer, watching TV, and outdoor activities.

The usefullness of ERTS-1 and supporting aircraft data for monitoring plant development in rangeland environments

NASA Technical Reports Server (NTRS)

Carneggie, D. M.; Degloria, S. D.

1972-01-01

The author has identified the following significant results. Preliminary analysis of ERTS-1 MSS imagery of annual and perennial rangeland in California yields the following observations: (1) Sufficient geomorphological detail can be resolved to differentiate upland and bottomland range sites in the foothill range areas. (2) Dry and green meadowland can be differentiated on MSS band 5. (3) Color composites prepared by NASA-Goddard were useful for locating perennial rangeland with varying amounts of herbaceous ground cover. (4) The ERTS-1 images received and interpreted cover nearly 50% of the state of California and show nearly two-thirds of the annual grassland type. (5) Satellite imagery obtained during the late summer season should be optimum for differentiating grassland from brushland and forested land. (6) The ERTS-1 imagery clearly shows areas which at one time were part of the annual grassland but which are now used for dry land farming (cropping of cereal grains). Similarly, the imagery show areas which have been converted from brushland to grassland.

40 CFR 35.1650-6 - Reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Reports. (a) States with Phase 1 projects shall submit semi-annual progress reports (original and one copy... in the next six months. (b) Phase 2. States with Phase 2 projects shall submit progress reports... Phase 2 project progress reports shall be determined by the size and complexity of the project, and...

40 CFR 35.1650-6 - Reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Reports. (a) States with Phase 1 projects shall submit semi-annual progress reports (original and one copy... in the next six months. (b) Phase 2. States with Phase 2 projects shall submit progress reports... Phase 2 project progress reports shall be determined by the size and complexity of the project, and...

Inhalation Toxicology Research Institute. Annual report, October 1, 1992--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nikula, K.J.; Belinsky, S.A.; Bradley, P.L.

1993-11-01

This annual report for the Inhalation Toxicology Research Institute for 1992-1993 consists of 60 individual reports prepared separately by investigators describing progress in their own projects. Most papers are 2-5 pages long.

Economics of installation of solar heating plants

NASA Astrophysics Data System (ADS)

Popel, O. S.; Frid, S. Y.; Shpiltayn, E. E.

1984-04-01

An engineering-economic analysis of solar heating plants for determination of their cost effectiveness involves calculating the maximum economically feasibile extra capital investment on their installation and calculating the fraction of the total heat demand covered by such a plant which makes replacement of conventional heating plant maximally economical. The annual economic effect of solar heating is calculated in terms of normalized cost differential, as criterion for its competitiveness with conventional heating. Plant performance characteristics, namely dependence of both the percent demand coverage and the annual cost differential on the area of solar radiation collectors is then considered. Analysis of the cost equation, assuming that the extra fixed cost is proportional to the collector area, reveals the necessary and sufficient condition for decrease of annual operating cost.

30th Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2008

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services, US Department of Education, 2011

2011-01-01

This is the 30th Annual Report to Congress on the Implementation of the Individuals with Disabilities Education Act, 2008. Section 664(d) of the Individuals with Disabilities Education Act (IDEA), as reauthorized in 2004, requires that the Department of Education report annually on the progress made toward the provision of a free appropriate…

Slowing Menthol's Progress: Differential Impact of a Tobacco Tax Increase on Cigarette Sales.

PubMed

Amato, Michael S; D'Silva, Joanne; Boyle, Raymond G

2016-05-01

The proportion of smokers who use menthol cigarettes has increased nationally since 2004, while use of non-menthol cigarettes is declining, suggesting that menthol may be undermining the effectiveness of population level tobacco control efforts. In 2013 Minnesota passed a $1.75 cigarette tax increase. We investigated whether sales of menthol and non-menthol cigarettes were differentially affected by the price increase. Cigarette sales data from convenience stores in the Minneapolis, Minnesota, metro area from January 2012, through May 2015, were obtained. Proportion of sales accounted for by menthol cigarettes was analyzed with segmented regression. Before the price increase, menthol cigarettes gained 2.21% (1.17, 3.12) of market share annually. Following the price increase, the trend slowed to 0.26% (-0.78, 1.56) annually. The slope before the price increase was significantly positive; the slope following the price increase did not significantly differ from zero. Sales of menthol cigarettes declined less rapidly than non-menthol cigarettes before the price increase. Sales of menthol and non-menthol cigarettes declined at more comparable rates after the price increase. Increasing the price of tobacco may help ensure declines in consumption are more evenly distributed across menthol and non-menthol cigarettes. Using sales data, we found that a trend of increasing market share for menthol cigarettes was significantly reduced by a $1.75 cigarette price increase. These results suggest that cigarette price increases, a core tobacco control policy, may have a greater effect on menthol smokers than non-menthol smokers. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer

NASA Astrophysics Data System (ADS)

Suzuki, H.; Mizuguchi, R.; Matsuhiro, M.; Kawata, Y.; Niki, N.; Nakano, Y.; Ohmatsu, H.; Kusumoto, M.; Tsuchida, T.; Eguchi, K.; Kaneko, M.; Moriyama, N.

2015-03-01

Computed tomography has been used for assessing structural abnormalities associated with emphysema. It is important to develop a robust CT based imaging biomarker that would allow quantification of emphysema progression in early stage. This paper presents effect of smoking on emphysema progression using annual changes of low attenuation volume (LAV) by each lung lobe acquired from low-dose CT images in longitudinal screening for lung cancer. The percentage of LAV (LAV%) was measured after applying CT value threshold method and small noise reduction. Progression of emphysema was assessed by statistical analysis of the annual changes represented by linear regression of LAV%. This method was applied to 215 participants in lung cancer CT screening for five years (18 nonsmokers, 85 past smokers, and 112 current smokers). The results showed that LAV% is useful to classify current smokers with rapid progression of emphysema (0.2%/year, p<0.05). This paper demonstrates effectiveness of the proposed method in diagnosis and prognosis of early emphysema in CT screening for lung cancer.

Annual Progress Report.

DTIC Science & Technology

1981-10-20

Jamming strategies. D W 3 k 4 2 i t-iew or I oev Be is o ~5e TU SS ia Y LA P 16CUTV10’:F-,n-zv fam o& nm.o ANNUAL PROGRESS REPORT for Office of Naval...7:ectrtcal Enineering and :ne j drtinateo lc.aqce ’_aboratory :nlersit )t :llinol$ It rbana-ChampaLgn -roana, Illinois ild~l Abstract La the...11 treat the related problems of -ioLsa ncortaincy. robust Winner filtering and minimax icace estima- n eac,, case :nere la Assumed to is sois

ANNUAL REPORT, JULY 1, 1958

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1959-02-01

This annual report of Brookhaven National Laboratory describes its program and activities for the fiscal year 1958. The progress and trends of the research program are presented along with a description of the operational, service, and administrative activities of the Laboratory. The scientific and technical details of the many research and development activities are covered more fully in scientific and technical periodicals and in the quarterly scientific progress reports and other scientiflc reports of the Laboratory. A list of all publications for July 1, 1957 to June 30, 1958, is given. Status and progress are given in fields of physics,more » accelerator development, instrumentation, applied mathematics, chemistry, nuclear engineering, biology, and medical research. (For preceding period see BNL-462.) (W.D.M.)« less

Conference scene: progress with promising human antibodies.

PubMed

Larrick, James W

2012-03-01

Antibodies and antibody-based therapeutics have become big business, with annual sales over US$50 billion, accounting for >6% of worldwide pharmaceutical revenues. Ten molecules have blockbuster status (>US$1 billion), with six generating more than US$6 billion in sales. In excess of 300 products based on this rapidly maturing technology are in clinical trials. The generation and manufacture of human antibodies is now routine, although the cost of goods remains an issue. Optimizing combinations of antibodies with other therapeutics (e.g., chemotherapy) is a major short-term goal, while target validation and product differentiation remain significant hurdles if growth is to continue. Some of the notable highlights of the recent 16th International Conference on Human Antibodies and Hybridomas meeting in Cannes, France are described below. The conference was sponsored by the international journal Human Antibodies, in association with the Integrative Medical Sciences Association (IMSA). The Program Chairman was Professor Mark Glassy, IMSA, San Diego, CA, USA.

25 CFR 30.116 - If a school fails to achieve its annual measurable objectives, what other methods may it use to...

Code of Federal Regulations, 2011 CFR

2011-04-01

... participated in the assessment. (b) Method B—Uniform Averaging Procedure. A school may use uniform averaging... 25 Indians 1 2011-04-01 2011-04-01 false If a school fails to achieve its annual measurable... Adequate Yearly Progress § 30.116 If a school fails to achieve its annual measurable objectives, what other...

25 CFR 30.116 - If a school fails to achieve its annual measurable objectives, what other methods may it use to...

Code of Federal Regulations, 2012 CFR

2012-04-01

... participated in the assessment. (b) Method B—Uniform Averaging Procedure. A school may use uniform averaging... 25 Indians 1 2012-04-01 2011-04-01 true If a school fails to achieve its annual measurable... Adequate Yearly Progress § 30.116 If a school fails to achieve its annual measurable objectives, what other...

25 CFR 30.116 - If a school fails to achieve its annual measurable objectives, what other methods may it use to...

Code of Federal Regulations, 2013 CFR

2013-04-01

... participated in the assessment. (b) Method B—Uniform Averaging Procedure. A school may use uniform averaging... 25 Indians 1 2013-04-01 2013-04-01 false If a school fails to achieve its annual measurable... Adequate Yearly Progress § 30.116 If a school fails to achieve its annual measurable objectives, what other...

25 CFR 30.116 - If a school fails to achieve its annual measurable objectives, what other methods may it use to...

Code of Federal Regulations, 2010 CFR

2010-04-01

... participated in the assessment. (b) Method B—Uniform Averaging Procedure. A school may use uniform averaging... 25 Indians 1 2010-04-01 2010-04-01 false If a school fails to achieve its annual measurable... Adequate Yearly Progress § 30.116 If a school fails to achieve its annual measurable objectives, what other...

25 CFR 30.116 - If a school fails to achieve its annual measurable objectives, what other methods may it use to...

Code of Federal Regulations, 2014 CFR

2014-04-01

... participated in the assessment. (b) Method B—Uniform Averaging Procedure. A school may use uniform averaging... 25 Indians 1 2014-04-01 2014-04-01 false If a school fails to achieve its annual measurable... Adequate Yearly Progress § 30.116 If a school fails to achieve its annual measurable objectives, what other...

32nd Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2010

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services, US Department of Education, 2014

2014-01-01

This is the 32nd Annual Report to Congress on the Implementation of the Individuals with Disabilities Education Act, 2010. Section 664(d) of the Individuals with Disabilities Education Act (IDEA) (P.L. 108-446), as reauthorized in 2004, requires that the Department of Education report annually on the progress made toward the provision of a free…

Applied Meteorology Unit (AMU)

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Wheeler, Mark

2010-01-01

The AMU has been in operation since September 1991. Tasking is determined annually with reviews at least semi-annually. The progress being made in each task is discussed in this report with the primary AMU point of contact reflected at the end of each task summary.

Annual Research Briefs - 1996

NASA Technical Reports Server (NTRS)

1996-01-01

This report contains the 1996 annual progress reports of the research fellows and students supported by the Center for Turbulence Research. Last year, CTR hosted twelve resident Postdoctoral Fellows, three Research Associates, four Senior Research Fellows, and supported one doctoral student and ten short term visitors.

Intelligent vehicle initiative : 2002 annual report -- saving lives through advanced vehicle safety technology

DOT National Transportation Integrated Search

2003-05-15

This Annual Report provides an overview of the Intelligent Vehicle Initiatives (IVIs) progress and accomplishments during 2002. The 1998 Transportation Efficiency Act for the 21st Century (TEA-21) authorized IVI as part of the Department of Tra...

Research for Progress in Education. Annual Report: Fiscal Year 1970.

ERIC Educational Resources Information Center

National Center for Educational Research and Development (DHEW/OE), Washington, DC.

This annual report begins with a brief overview of cooperative research objectives and background. The five major sections are 1) "Cooperative Research Authorization" including the basic authorizations and subsequent amendments; 2) "Management Policies and Procedures;" 3) "Definitions and Distinctions" covering major…

Proceedings of the second annual Forest Inventory and Analysis symposium; Salt Lake City, UT. October 17-18, 2000

Treesearch

Gregory A. Reams; Ronald E. McRoberts; Paul C. van Deusen; [Editors

2001-01-01

Documents progress in developing techniques in remote sensing, statistics, information management, and analysis required for full implementation of the national Forest Inventory and Analysis program’s annual forest inventory system.

Tropical rainforests dominate multi-decadal variability of the global carbon cycle

NASA Astrophysics Data System (ADS)

Zhang, X.; Wang, Y. P.; Peng, S.; Rayner, P. J.; Silver, J.; Ciais, P.; Piao, S.; Zhu, Z.; Lu, X.; Zheng, X.

2017-12-01

Recent studies find that inter-annual variability of global atmosphere-to-land CO2 uptake (NBP) is dominated by semi-arid ecosystems. However, the NBP variations at decadal to multi-decadal timescales are still not known. By developing a basic theory for the role of net primary production (NPP) and heterotrophic respiration (Rh) on NBP and applying it to 100-year simulations of terrestrial ecosystem models forced by observational climate, we find that tropical rainforests dominate the multi-decadal variability of global NBP (48%) rather than the semi-arid lands (35%). The NBP variation at inter-annual timescales is almost 90% contributed by NPP, but across longer timescales is progressively controlled by Rh that constitutes the response from the NPP-derived soil carbon input (40%) and the response of soil carbon turnover rates to climate variability (60%). The NBP variations of tropical rainforests is modulated by the ENSO and the PDO through their significant influences on temperature and precipitation at timescales of 2.5-7 and 25-50 years, respectively. This study highlights the importance of tropical rainforests on the multi-decadal variability of global carbon cycle, suggesting that we need to carefully differentiate the effect of NBP long-term fluctuations associated with ocean-related climate modes on the long-term trend in land sink.

Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Cooperative Registry.

PubMed

Cooper, D S; Specker, B; Ho, M; Sperling, M; Ladenson, P W; Ross, D S; Ain, K B; Bigos, S T; Brierley, J D; Haugen, B R; Klein, I; Robbins, J; Sherman, S I; Taylor, T; Maxon, H R

1998-09-01

The ideal therapy for differentiated thyroid cancer is uncertain. Although thyroid hormone treatment is pivotal, the degree of thyrotropin (TSH) suppression that is required to prevent recurrences has not been studied in detail. We have examined the relation of TSH suppression to baseline disease characteristics and to the likelihood of disease progression in a cohort of thyroid cancer patients who have been followed in a multicenter thyroid cancer registry that was established in 1986. The present study describes 617 patients with papillary and 66 patients with follicular thyroid cancer followed annually for a median of 4.5 years (range 1-8.6 years). Cancer staging was assessed using a staging scheme developed and validated by the registry. Cancer status was defined as no residual disease; progressive disease at any follow-up time; or death from thyroid cancer. A mean TSH score was calculated for each patient by averaging all available TSH determinations, where 1 = undetectable TSH; 2 = subnormal TSH; 3 = normal TSH; and 4 = elevated TSH. Patients were also grouped by their TSH scores: group 1: mean TSH score 1.0-1.99; group 2: mean TSH score 2.0-2.99; group 3: mean TSH score 3.0-4.0. The degree of TSH suppression did not differ between papillary and follicular thyroid cancer patients. However, TSH suppression was greater in papillary cancer patients who were initially classified as being at higher risk for recurrence. This was not the case for follicular cancer patients, where TSH suppression was similar for all patients. For all stages of papillary cancer, a Cox proportional hazards model showed that disease stage, patient age, and radioiodine therapy all predicted disease progression, but TSH score category did not. However, TSH score category was an independent predictor of disease progression in high risk patients (p = 0.03), but was no longer significant when radioiodine therapy was included in the model (p = 0.09). There were too few patients with follicular cancer for multivariate analysis. These data suggest that physicians use greater degrees of TSH suppression in higher risk papillary cancer patients. Our data do not support the concept that greater degrees of TSH suppression are required to prevent disease progression in low-risk patients, but this possibility remains in high-risk patients. Additional studies with more patients and longer follow-up may provide the answer to this important question.

Laboratory directed research and development 2006 annual report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westrich, Henry Roger

2007-03-01

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 2006. In addition to a programmatic and financial overview, the report includes progress reports from 430 individual R&D projects in 17 categories.

Maximizing the Prospects for Progress Against Cancer

Cancer.gov

The 2018 American Society of Clinical Oncology annual meeting featured numerous, potentially practice changing research findings, according to NCI Director Dr. Norman Sharpless. In this Cancer Currents post, Dr. Sharpless discusses the rapid pace of progress in cancer research.

Preparing for the Annual Audit.

ERIC Educational Resources Information Center

Nuehring, Bert

2002-01-01

Proposes several key questions that school district business officials should answer to prepare for an annual financial audit involving auditor information and resource needs, district and auditor monitoring and reporting on the audit progress, and reporting the results of the audit to the board of education. (PKP)

Seasonal and Perennial Changes in the Distribution of Water in the Sapwood of Conifers in a Sub-Frigid Zone1

PubMed Central

Utsumi, Yasuhiro; Sano, Yuzou; Funada, Ryo; Ohtani, Jun; Fujikawa, Seizo

2003-01-01

An analysis was made of progressive changes in patterns of cavitation in the sapwood of three species of conifer (Larix kaempferi, Abies sachalinensis, and Picea jezoensis) that were growing in a sub-frigid zone. In all three conifers, all tracheids of the newly forming outermost annual ring were filled with water or cytoplasm during the period from May to August. However, many tracheids in the transition zone from earlywood to latewood lost water in September, presumably through drought-induced cavitation. Cavitated tracheids tended to be continuously distributed in a tangential direction. Subsequently, some earlywood tracheids of the outermost annual ring lost water during the period from January to March. This was associated with freeze-thaw cycles. In the second and third annual rings from the cambium of all three conifers, the lumina of most tracheids in the transition zone from earlywood to latewood contained no water. In contrast, some latewood tracheids near the annual ring boundary and many earlywood tracheids retained water in their lumina. The third annual ring had more cavitated tracheids than the second annual ring. Our observations indicated that cavitation progressed gradually in the tracheids of the conifers and that they were never refilled once cavitation had occurred. The region involved in water transport in conifers did not include the entire sapwood and differed among annual rings. PMID:12692342

Genetic progress in homogeneous regions of wheat cultivation in Rio Grande do Sul State, Brazil.

PubMed

Follmann, D N; Cargnelutti Filho, A; Lúcio, A D; de Souza, V Q; Caraffa, M; Wartha, C A

2017-03-30

The State of Rio Grande do Sul (RS) stands out as the largest wheat producer in Brazil. Wheat is the most emphasized winter cereal in RS, attracting public and private investments directed to wheat genetic breeding. The study of genetic progress should be performed routinely at breeding programs to study the behavior of cultivars developed for homogeneous regions of cultivation. The objectives of this study were: 1) to evaluate the genetic progress of wheat grain yield in RS; 2) to evaluate the influence of cultivar competition trial stratification in homogeneous regions of cultivation on the study of genetic progress. Grain yield data of 122 wheat cultivars evaluated in 137 trials arranged in randomized block design with three or four replications were used. Field trials were carried out in 23 locations in RS divided into two homogeneous regions during the period from 2002 to 2013. Genetic progress for RS and homogeneous regions was studied utilizing the method proposed by Vencovsky. Annual genetic progress for wheat grain yield during the period of 12 years in the State of RS was 2.86%, oscillating between homogeneous regions of cultivation. The difference of annual genetic progress in region 1 (1.82%) in relation to region 2 (4.38%) justifies the study of genetic progress by homogeneous regions of cultivation.

76 FR 66946 - Notice of Submission of Proposed Information Collection to OMB Annual Progress Reports for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... to HUD based on the progress reported in implementing the EZs' strategic plans. Businesses located in... based on the progress reported in implementing the EZs' strategic plans. Businesses located in the EZs.... The primary purpose of this collection is to continue current data reporting for Rounds, I, II, and...

76 FR 64369 - Notice of Submission of Proposed Information Collection to OMB Annual Progress Reports for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-18

... based on the progress reported in implementing the EZs' strategic plans. Businesses located in the EZs... based on the progress reported in implementing the EZs' strategic plans. Businesses located in the EZs... primary purpose of this collection is to continue current data reporting for Rounds, I, II, and III...

Bibliographical Work in New Zealand, 1980-1982. Work in Progress and Work Published.

ERIC Educational Resources Information Center

Millett, A. P. U., Comp.; Cole, F. T. H., Comp.

Formerly published as an irregular feature of New Zealand Libraries, these three annual bibliographies (1980, 1981, 1982) list bibliographical work in progress, as well as enumerative and subject bibliographies published in New Zealand from July 1977 to June 1982. It is noted that bibliographical work in progress is compiled from an annual…

Louisiana Believes: Annual Report 2013

ERIC Educational Resources Information Center

Louisiana Department of Education, 2013

2013-01-01

"Louisiana Believes" is the state's comprehensive plan to ensure every student is on track to a professional career or a college degree. This annual report details Louisiana's progress toward that objective during the 2012-2013 school year, along with strategy for the coming school year. "Louisiana Believes" has three…

77 FR 65903 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

... proposal; annual progress reports are required for awards of a two- to five-year duration. Final reports.../ . Responses are voluntary. No questions of a ``sensitive'' nature are asked. Affected Public: Research... benefits. Frequency of Collection: Annually: Grant proposals and reporting; Every two to five years...

Clinical Investigation Program: Annual Progress Report

DTIC Science & Technology

1992-09-30

Academy of Surgical Research, Chicago, Illinois; Yucatan Miniature Swine as a Model System for the Studyt of Vocal Fold Vibratory Function; 6th Annual...34(14)e". (15) Study Objective: Compare two enteral formulas in respect to nutritional aspects. (16) Technical Approach: Protocol will take place in

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.

PubMed

Papaspyridonos, Marianna; Matei, Irina; Huang, Yujie; do Rosario Andre, Maria; Brazier-Mitouart, Helene; Waite, Janelle C; Chan, April S; Kalter, Julie; Ramos, Ilyssa; Wu, Qi; Williams, Caitlin; Wolchok, Jedd D; Chapman, Paul B; Peinado, Hector; Anandasabapathy, Niroshana; Ocean, Allyson J; Kaplan, Rosandra N; Greenfield, Jeffrey P; Bromberg, Jacqueline; Skokos, Dimitris; Lyden, David

2015-04-29

A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors, such as TGFβ, is responsible for the switch from dendritic cell (DC) differentiation to myeloid-derived suppressor cell expansion during tumour progression. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumour-derived factors re-creates it. Id1 overexpression leads to systemic immunosuppression by downregulation of key molecules involved in DC differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression. Furthermore, advanced melanoma patients have increased plasma TGFβ levels and express higher levels of ID1 in myeloid peripheral blood cells. This study reveals a critical role for Id1 in suppressing the anti-tumour immune response during tumour progression and metastasis.

Pacific Northwest Laboratory annual report for 1979 to the DOE Assistant Secretary for Environment. Part 5. Environmental assessment, control, health, and safety

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baalman, R.W.; Dotson, C.W.

1980-02-01

Part 5 of the 1979 Annual Report to the Department of Energy Assistant Secretary for the Environment presents Pacific Northwest Laboratory's progress on work performed for the Office of Technology Impacts, the Office of Environmental Compliance and Overview, and the Office of Health and Environmental Research. The report is in four sections, corresponding to the program elements: technology impacts, environmental control engineering, operational and environmental compliance, and human health studies. In each section, articles describe progress made during FY 1979 on individual projects.

Health physics division annual progress report for period ending June 30, 1977

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-07-01

This annual progress report follows, as in the past, the organizational structure of the Health Physics Division. Each part is a report of work done by a section of the division: Assessment and Technology Section (Part I), headed by H.W. Dickson; Biological and Radiation Physics Section (Part II), H.A. Wright; Chemical Physics and Spectroscopy Section (Part III), W.R. Garrett; Emergency Technology Section (Part IV), C.V. Chester, Medical Physics and Internal Dosimetry Section (Part V), K.E. Cowser; and the Analytic Dosimetry and Education Group (Part VI), J.E. Turner.

Chemical and biological nonproliferation program. FY99 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2000-03-01

This document is the first of what will become an annual report documenting the progress made by the Chemical and Biological Nonproliferation Program (CBNP). It is intended to be a summary of the program's activities that will be of interest to both policy and technical audiences. This report and the annual CBNP Summer Review Meeting are important vehicles for communication with the broader chemical and biological defense and nonproliferation communities. The Chemical and Biological Nonproliferation Program Strategic Plan is also available and provides additional detail on the program's context and goals. The body of the report consists of an overviewmore » of the program's philosophy, goals and recent progress in the major program areas. In addition, an appendix is provided with more detailed project summaries that will be of interest to the technical community.« less

[Annual production of moss layer in dark coniferous forests of Ket-Chulym Forest District (by the example of Moss Hylocomium splendens)].

PubMed

Koshurnikova, N N

2007-01-01

The biological production of the moss layer was analyzed in dark coniferous stands in progressive succession in the southern taiga in West Siberia. The rate of organic matter production by mosses changed from 15-22.2 g/(m2 y) in 50-90-year-old fir forests to 51.6 g/(m2 y) in 170-year-old mixed Siberian pine-spruce-fir stands. In forest phytocenosis that were formed with species replacement (after cuttings with understory clearing), the annual moss production (net primary production) ranged from 2.8 to 20.6 g/(m2 y). The annual moss cover production amounted to 35-36% of the moss photosynthetic biomass irrespective of the type of native stand progressive succession and the stand age.

Annual Report, 1986. Southern Coalition for Educational Equity.

ERIC Educational Resources Information Center

David, Jane L.

This annual report summarizes the work and progress of programs which promote effective education in 11 Southern states. Working cooperatively with other groups, this advocacy organization has developed a model for putting effective schools research into practice. The Effective Schools Model has been accepted for use by the New Orleans Public…

FY 2012 Lightweight Materials Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warren, David C.

2013-04-15

The FY 2012 Annual Progress Report for Lightweight Materials provides a detailed description of the activities and technical accomplishments which focuses on the development and validation of advanced materials and manufacturing technologies to significantly reduce light and heavy duty vehicle weight without compromising other attributes such as safety, performance, recyclability, and cost.

Annual Progress Report, 1976. Southern Rural Development Center, Mississippi State University. SRDC Series Publication No. 15.

ERIC Educational Resources Information Center

Southern Rural Development Center, State College, MS.

Covering the 1976 activities of the Southern Rural Development Center (SRDC), this third annual report describes SRDC's: history; organization; regional workshops; functional networks; network bibliographies and other publications; Title V reports; grant received for training in rural development; orientation visits; consultants; information…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Maryland

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Maryland's accomplishments, lessons learned, challenges, and strategies Maryland will implement to address those challenges. Maryland's remarkable progress in increasing participation in their tiered quality rating and improvement…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Vermont

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Vermont's accomplishments, lessons learned, challenges, and strategies Vermont will implement to address those challenges. Vermont's remarkable progress in increasing participation in their tiered quality rating and improvement system,…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Pennsylvania

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Pennsylvania's accomplishments, lessons learned, challenges, and strategies Pennsylvania will implement to address those challenges. Pennsylvania's remarkable progress in increasing participation in their tiered quality rating and…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Minnesota

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Minnesota's accomplishments, lessons learned, challenges, and strategies Minnesota will implement to address those challenges. Minnesota's remarkable progress in increasing participation in their tiered quality rating and improvement…

The World Fertility Survey: January 1976-December 1976. Annual Report.

ERIC Educational Resources Information Center

World Fertility Survey, London (England).

This annual report describes, through narrative and statistical tables, the progress made in 1976 by the World Fertility Survey (WFS), an international population research program. The function of the WFS is to assist a large number of interested countries, particularly the developing countries, in carrying out nationally representative,…

OMS 1987 Annual Report.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

Designed to serve both as an activity report on Office of Management Studies (OMS) progress during 1987 and a catalog of OMS services and products, this annual report focuses on the management of technology in a scholarly environment. Programs and services are reported in five sections: (1) Applied Research and Development (the Institute on…

Annual Energy Outlook

EIA Publications

2017-01-01

The Annual Energy Outlook provides modeled projections of domestic energy markets through 2050, and includes cases with different assumptions of macroeconomic growth, world oil prices, technological progress, and energy policies. With strong domestic production and relatively flat demand, the United States becomes a net energy exporter over the projection period in most cases.

Arizona Adult Education Annual Performance Report. Fiscal Year 1993.

ERIC Educational Resources Information Center

Arizona State Dept. of Education, Phoenix. Div. of Adult Education.

This annual performance report on Arizona adult education begins with 3 pages of financial reports and statistical information presented in 9 tables and 19 charts. Tables and charts depict the following: participants by class type, age group, ethnic background, student progress, reason for separation before completion, and status; sites with…

78 FR 66953 - Agency Information Collection Activities: Extension of a Currently Approved Collection; Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... DEPARTMENT OF JUSTICE [OMB Number 1122-0003] Agency Information Collection Activities: Extension of a Currently Approved Collection; Annual Progress Report for the STOP Formula Grants Program ACTION: 60-Day notice. The Department of Justice, Office on Violence Against Women (OVW) will be [[Page 66954

Missouri local technical assistance program at Missouri University of Science and Technology (formerly University of Missouri--Rolla) : annual progress report January-December 2007.

DOT National Transportation Integrated Search

2009-02-01

This annual report is a summary of the activities during 2007 for the Missouri Local Technical Assistance Program (Missouri LTAP), which is located at Missouri University of Science and Technology. The report highlights Missouri LTAPs performance ...

Environmental Sciences Division annual progress report for period ending September 30, 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1984-04-01

This annual report summarizes activities in the Aquatic Ecology, Earth Sciences, Environmental Analyses, and Terrestrial Ecology sections, as well as in the Fossil Energy, Biomass, Low-Level Waste Research and Management, and Global Carbon Cycle Programs. Separate abstracts have been prepared for each section. (ACR)

Southern Rural Development Center Annual Progress Report, 1996.

ERIC Educational Resources Information Center

Southern Rural Development Center, Mississippi State, MS.

This annual report of the Southern Rural Development Center (SRDC) describes the agency's extension and research activities from October 1, 1995, to October 1, 1996. SRDC is one of four regional centers coordinating rural development research and extension education programs cooperatively with the land-grant institutions. SRDC cooperates with 29…

Compilation of 1985 annual reports of the Navy elf (extremely low frequency) communications system ecological monitoring program. Volume 2. Tabs D-G. Annual progress report, January-December 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Band, R.N.; Snider, R.J.; Snider, R.M.

1986-07-01

This volume consists of the following reports: Soil Amoeba; Soil and Litter Arthropoda and Earthworm Studies; Biological Studies on Pollinating Insects: Megachilid Bees; Small Vertebrates: Small Mammals and Nesting Birds.

Basic Communication Course Annual. Volume 8.

ERIC Educational Resources Information Center

Newburger, Craig, Ed.

This volume of an annual collection presents 13 essays relating to instruction in the basic communication course. Six of the essays are on the theme of cultural diversity in the basic course. The essays are: "The Differential Impact of a Basic Public Speaking Course on Perceived Communication Competencies in Class, Work, and Social…

State University System of Florida

ERIC Educational Resources Information Center

Board of Governors, State University System of Florida, 2012

2012-01-01

This paper presents some information about the State University System of Florida. The following are presented in this paper: (1) University Work Plans and Annual Reports; (2) State University System 2009 Annual Report; (3) Quick Facts: Planned New Degree Programs--2010 to 2013; (4) State University System Tuition Differential Summary, FY…

Microenvironmental Regulation of Mammary Carcinogenesis

DTIC Science & Technology

2008-06-01

cells. These models share many of the hallmarks of multistage human breast cancer development including histological disease progression and immune cell... developed by Muller and colleagues20, represents a reasonable recapitulation of late-stage human breast cancer as determined by histological progression ...Annual Progress Report d. Develop a profile of proteolytic activities in normal and neoplastic mammary tissues from mouse models of mammary

Predicting Disease Progression in Scleroderma with Skin and Blood Biomarkers

DTIC Science & Technology

2014-10-01

AWARD NUMBER: W81XWH-13-1-0452 TITLE: Predicting Disease Progression in Scleroderma with Skin...Annual 3. DATES COVERED 23Sep 2013 – 22 Sep 2014 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Predicting Disease Progression in...Scleroderma (Systemic Sclerosis, SSc) is a chronic, incurable autoimmune disease associated with high morbidity and mortality primarily due to SSc-lung

The Chip-Scale Atomic Clock - Recent Development Progress

DTIC Science & Technology

2004-09-01

35th Annual Precise Time and Time Interval (PTTI) Meeting 467 THE CHIP-SCALE ATOMIC CLOCK – RECENT DEVELOPMENT PROGRESS R. Lutwak ...1] R. Lutwak , et al., 2003, “The Chip-Scale Atomic Clock – Coherent Population Trapping vs. Conventional Interrogation,” in

Assessment Program Technical Progress Report, 1996-1997.

ERIC Educational Resources Information Center

McCown, Laurie; Fanning, Erin; Eickmeyer, Barbara

Coconino Community College (CCC) annually assesses its institutional effectiveness to demonstrate its commitment to improving programs and services to students. The 1996-97 Assessment Program Technical Progress Report records the assessment and institutional activities enacted during the academic year, detailing the assessment model, timelines,…

FY2013 Progress Report for Fuel & Lubricant Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2014-02-01

Annual progress report for Fuel & Lubricant Technologies. The Fuel & Lubricant Technologies Program supports fuels and lubricants research and development (R&D) to provide vehicle manufacturers and users with cost-competitive options that enable high fuel economy with low emissions, and contribute to petroleum displacement.

Higher Education in Scotland: Differentiation and Diversion? The Impact of College-University Progression Links

ERIC Educational Resources Information Center

Gallacher, Jim

2014-01-01

This paper addresses the issue of the impact of expansion and differentiation on widening access to higher education. In particular, it considers the impact of the growing importance of full-time short-cycle higher education in Scotland's colleges of further and higher education, the progression pathways which have now been established from these…

Accelerated Progress Through Self-Determination. Second Annual Report of the Choctaw Self-Determination Project, July 1, 1972 - October 31, 1973.

ERIC Educational Resources Information Center

Mississippi Band of Choctaw Indians, Philadelphia.

Self-determination for the Choctaw tribal government and its people was reflected in the progress made in program development. Programs in effect during fiscal year (FY) 1973 covered the full range of economic and social needs of the Choctaw people. Designed to complement the progress achieved during FY 1972, the following four developmental…

Economic Differentiation as a Determinant of Higher Education Pricing and Expenditure Policies and State-wide Public Policy: Implications for Governance. ASHE 1983 Annual Meeting Paper.

ERIC Educational Resources Information Center

Alfred, Richard L.

A study of the impact of economic differentiation on institutional pricing and expenditure policies, higher education public policy, and governance in public colleges and universities is described. It is suggested that economic differentiation is a likely determinant of variation in institutional expenditure and pricing policies and higher…

Natural history of Niemann-Pick disease type C in a multicentre observational retrospective cohort study.

PubMed

Wraith, J E; Guffon, N; Rohrbach, M; Hwu, W L; Korenke, G C; Bembi, B; Luzy, C; Giorgino, R; Sedel, F

2009-11-01

Niemann-Pick disease type C (NP-C) is a devastating genetic disorder characterised by progressive neurological deterioration. However, data on the progression of neurological manifestations, particularly across different patient age-of-disease onsets, are limited. This is an observational retrospective cohort study designed to assess the progression of neurological disease in patients with NP-C. Physicians were asked to retrospectively complete a web-based questionnaire for each patient, at diagnosis and at up to three follow-up visits. An NP-C-specific disability scale was used to measure disease progression. The scale comprised four key parameters of neurological disease progression; ambulation, manipulation, language and swallowing. Disease progression was evaluated based on the annual rate of change in each parameter and the composite score using a linear mixed model analysis, and by classifying patients according to the number of worsened parameters during the observation period. Data were collected from 57 patients. The rate of deterioration was similar across the four individual parameters of the disability scale. The mean (95% CI) annual disease progression was +0.12 (0.09, 0.15) units. Among patients with a time interval of at least 1 year between diagnosis and last visit (n=49), 42 (86%) patients had progressed disease and 7 (14%) patients had stable disease. Disease progression was consistently more rapid in patients diagnosed in early childhood, compared with those diagnosed in late childhood, or with juvenile or adult presentation. In conclusion, our findings showed a progression in all four parameters of the disability scale, representing a continuous, unbroken progression of neurological manifestations.

75 FR 65296 - Notice of Public Information Collection Requirements Submitted to OMB for Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

.... SUPPLEMENTARY INFORMATION: OMB Number: OMB 0412-New. Form Number: AID 321-2. Title: Mentor Prot[eacute]g[eacute] Program--Annual Report. Type of Submission: New Information Collection. Purpose: The mentors are required to report on the progress made under each active Mentor-Prot[eacute]g[eacute] Agreement annually...

Utah System of Higher Education 2015-16 Annual Report

ERIC Educational Resources Information Center

Utah System of Higher Education, 2016

2016-01-01

This annual report describes Utah System of Higher Education's progress in the 2015-2016 academic year in the following areas: (1) Strategic plan; (2) Enrollment and completion; (3) Paying for college; (4) Funding higher education; (5) College preparation; (6) Concurrent enrollment and math; (7) Outreach and access; and (8) Industry and the…

78 FR 13072 - Seventh Annual Drug Information Association/Food and Drug Administration Statistics Forum-2013...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... therapeutic drugs and biologics. This meeting is intended to be an open forum for the timely discussion of... data and measuring the progress being made in designing and implementing innovative solutions. DATES.... Background This annual FDA/DIA statistics forum will establish a unique, open, international forum for...

Annual Survey of Colleges, 1986-1987. Summary Statistics.

ERIC Educational Resources Information Center

College Entrance Examination Board, New York, NY.

Results of the College Board's Annual Survey of Colleges for 1986-1987 are presented, based on responses from 3,093 two-year and four-year institutions. Data for 1985 and trends for 1980 and 1984 cover undergraduate enrollments, student progress, academic programs, degrees conferred, and student financial aid. While most of the tables present…

Annual Progress Report, January 1, 1974-December 31, 1974. [Southern Rural Development Center, Mississippi State University.

ERIC Educational Resources Information Center

Southern Rural Development Center, State College, MS.

The Southern Rural Development Center's (SRDC) first annual report documents its organizational structure and provides a point by point summary of accomplishments relative to the following goals: (1) Develop, plan, and inventory existing rural development research knowledge; (2) Inventory rural development research needs and priorities; (3)…

Annual Progress Report, 1977. Southern Rural Development Center, Mississippi State University. SRDC Series No. 23.

ERIC Educational Resources Information Center

Linder, William W.

Summarizing Southern Rural Development Center (SRDC) activities and achievements during the October 1976-September 1977 fiscal year, this fourth annual report indicates that SRDC has been able to support rural development programs at land-grant institutions through sponsorship of workshops; issuance of publications, bibliographies, and a quarterly…

76 FR 19099 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Servicers Review (ASPR), and Annual Budget Expenses Request and Estimated Expenditures (CFS-101). OMB No... called the CFS-101. The APSR is a Yearly report that discusses progress made by a State, Territory or... plan period. The CFS-101 has three parts. Part I is an annual budget request for the upcoming fiscal...

Environmental Quality, the Sixth Annual Report of the Council on Environmental Quality.

ERIC Educational Resources Information Center

Council on Environmental Quality, Washington, DC.

This sixth annual report discusses the state of the environment and progress accomplished in meeting the goals and objectives established for an improved environment. Each of the seven chapters deals with an important environmental parameter. Chapter one is devoted to carcinogens in the environment. Chapter two presents perspectives on the…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. New Jersey

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes New Jersey's accomplishments, lessons learned, challenges, and strategies New Jersey will implement to address those challenges. New Jersey's remarkable progress in increasing participation in their tiered quality rating and improvement…

76 FR 68786 - Agency Information Collection Activities: Extension of a Currently Approved Collection; Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

... DEPARTMENT OF JUSTICE [OMB Number 1122-0003] Agency Information Collection Activities: Extension of a Currently Approved Collection; Annual Progress Report for the STOP Formula Grants Program ACTION: 60-Day notice of information collection under review. The Department of Justice, Office on Violence Against Women (OVW) will be submitting the...

FY 2009 National Renewable Energy Laboratory (NREL) Annual Report: A Year of Energy Transformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2010-01-01

This FY2009 Annual Report surveys the National Renewable Energy Laboratory's (NREL) accomplishments in renewable energy and energy efficiency research and development, commercialization and deployment of technologies, and strategic energy analysis. It offers NREL's vision and progress in building a clean, sustainable research campus and reports on community involvement.

Invasion of the exotic grasses: Mapping their progression via satellite

Treesearch

Eric B. Peterson

2008-01-01

Several exotic annual grass species are invading the Intermountain West. After disturbances including wildfire, these grasses can form dense stands with fine fuels that then shorten fire intervals. Thus invasive annual grasses and wildfire form a positive feedback mechanism that threatens native ecosystems. Chief among these within Nevada are Bromus tectorum...

U.S. Army Medical Bioengineering Research and Development Laboratory Annual Progress Report FY 1985. Volume 1

DTIC Science & Technology

1985-10-01

heterotrophic carbon dioxide fixa- tion. An assay for T2 toxin using the yeast Cryptococcus luteolus was evaluated as a rapid screening device for toxic...Bioassay for Mycotoxins Using Cryptococcus luteolus with Tetrazolium Salts." Poster session at the American Soc. for Microbiol. Annual Meeting, March

12 CFR 705.6 - Community needs plan.

Code of Federal Regulations, 2010 CFR

2010-01-01

... union's board of directors will report on the progress of providing needed community services to the credit union members once a year, either at the annual meeting or in a written report sent to all members. The credit union will also submit the written report or a summary of the report given at the annual...

Annual Review of Psychology. Volume 22, 1971.

ERIC Educational Resources Information Center

Mussen, Paul H., Ed.; Rosenzweig, Mark R., Ed.

The Annual Review of Psychology is compiled to provide authoritative evaluation of progress in both the traditional and the new areas of psychology. The 1971 edition includes the following topics and authors: Basic Drives, by Frank W. Finger and Douglas G. Mook; Behavioral Genetics, by Gardner Lindzey and others; Audition, by David H. Raab;…

Office of Management Services 1989 Annual Report.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

Designed to serve both as an activity report on Office of Management Services (OMS) progress during 1989 and a catalog of OMS services and products, this annual report focuses on the management of human and technical resources in a scholarly environment. Programs and services are reported in four sections: (1) Applied Research and Development (the…

FY 1999 Annual Self-Evaluation Report of the Pacific Northwest National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Randy R. LaBarge

1999-11-05

This is a report of the Pacific Northwest National Laboratory's (Pacific Northwest's) FY1999 Annual Self-Evaluation Report. This report summarizes our progress toward accomplishment of the critical outcomes, objectives, and performance indicators as delineated in the FY1999 Performance Evaluation & Fee Agreement. It also summarizes our analysis of the results of Pacific Northwest's Division and Directorate annual self-assessments, and the implementation of our key operational improvement initiatives. Together, these provide an indication of how well we have used our Integrated Assessment processes to identify and plan improvements for FY2000. As you review the report you will find areas of significantly positivemore » progress; you will also note areas where I believe the Laboratory could make improvements. Overall, however, I believe you will be quite pleased to note that we have maintained, or exceeded, the high standards of performance we have set for the Laboratory.« less

Ecological requirements for pallid sturgeon reproduction and recruitment in the Missouri River—Annual report 2013

USGS Publications Warehouse

Delonay, Aaron J.; Jacobson, Robert B.; Chojnacki, Kimberly A.; Braaten, Patrick J.; Buhl, Kevin J.; Eder, Brandon L; Elliott, Caroline M.; Erwin, Susannah O.; Fuller, David B.; Haddix, Tyler M.; Ladd, Hallie L.A.; Mestl, Gerald E.; Papoulias, Diana M.; Rhoten, Jason C.; Wesolek, Christopher J.; Wildhaber, Mark L.

2016-01-20

The research tasks in the 2013 scope of work emphasized understanding reproductive migrations and spawning of adult pallid sturgeon, and hatch and drift of free embryos and larvae. These tasks were addressed in four study sections located in three hydrologically and geomorphologically distinct parts of the Missouri River Basin: the Upper Missouri River downstream from Fort Peck Dam, including downstream reaches of the Milk River, the Lower Yellowstone River, and the Lower Missouri River downstream from Gavins Point Dam. The research is designed to inform management decisions related to channel re-engineering, flow modification, and pallid sturgeon population augmentation on the Missouri River, and throughout the range of the species. Research and progress made through this project are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by the Comprehensive Sturgeon Research Project during 2013.

Research on Speech Perception. Progress Report No. 13.

ERIC Educational Resources Information Center

Pisoni, David B.; And Others

Summarizing research activities in 1987, this is the thirteenth annual report of research on speech perception, analysis, synthesis, and recognition conducted in the Speech Research Laboratory of the Department of Psychology at Indiana University. The report includes extended manuscripts, short reports, progress reports, and information on…

International VLBI Service for Geodesy and Astrometry 2005 Annual Report

NASA Technical Reports Server (NTRS)

Behrend, Dirk (Editor); Baver, Karen D. (Editor)

2006-01-01

This volume of reports is the 2005 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2005 Annual Report documents the work of these IVS components over the period January 1, 2005 through December 31, 2005. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2005.

International VLBI Service for Geodesy and Astrometry 2007 Annual Report

NASA Technical Reports Server (NTRS)

Behrend, D. (Editor); Baver, K. D. (Editor)

2008-01-01

This volume of reports is the 2007 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2007 Annual Report documents the work of these IVS components over the period January 1, 2007 through December 31, 2007. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2007.

International VLBI Service for Geodesy and Astrometry 2008 Annual Report

NASA Technical Reports Server (NTRS)

Behrend, Dirk; Baver, Karen D.

2009-01-01

This volume of reports is the 2008 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2008 Annual Report documents the work of these IVS components over the period January 1, 2008 through December 31, 2008. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2008.

International VLBI Service for Geodesy and Astrometry 2011 Annual Report

NASA Technical Reports Server (NTRS)

Baver, Karen D. (Editor); Behrend, Dirk

2012-01-01

This volume of reports is the 2011 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2011 Annual Report documents the work of these IVS components over the period January 1, 2011 through December 31, 2011. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2011.

LLE 2009 annual report, October 2008-September 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

none, none

2010-01-01

The fiscal year ending September 2009 (FY2009) concluded the second year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year. It also reports on LLE’s progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the National Laser Users’ Facility (NLUF), and other external users; and programs focusingon the education of high school, undergraduate, and graduate students during the year.

Role of neurotransmitter Substance P in progression of oral squamous cell carcinoma.

PubMed

Mehboob, Riffat; Tanvir, Imrana; Warraich, Riaz Ahmad; Perveen, Shahida; Yasmeen, Sehrish; Ahmad, Fridoon Jawad

2015-03-01

Oral squamous cell carcinoma (OSCC) is the most frequent type of head and neck cancers. In the present study, we evaluated the expression and distribution of Substance P (SP) in different grades of OSCC and role of SP in its proliferation and progression. Forty OSCC biopsies were immunohistochemically analyzed by using SP antibody, including 29 male and 11 female cases. 35% were well differentiated, 35% moderately differentiated and 30% poorly differentiated OSCC. The majority of patients were in the age range of 41-80 years. 62% of the cases were positive for SP. SP positivity was expressed in the cytoplasm of the tumor cells. Most of the positive cases were from the tongue region. 93% of moderately differentiated, 92% of poorly differentiated and 8% of well-differentiated carcinomas were SP-positive, but SP expression intensity was highest in poorly differentiated cases (+3). More positive patients were males (68.96% of all male patients) with moderately and poorly differentiated OSCC. Among all positive cases, 48% were poorly differentiated, 48% moderately differentiated and 4% well differentiated. Strong expression of SP in poorly and moderately differentiated cases suggests a role of SP in the progression and development of tumor. Expression of SP in the current study increased as the proliferation of cells increased. Prevalence of oral cancer in males may be due to the fact that they smoke and use pan, chewing gum, beetle nut etc. in this region. SP antagonists can help in the reduction and inhibition of oral cancer. SP has a diagnostic value with sensitivity of 92.5% and specificity of 93.7%. The positive predictive value is 96.2% and the negative predictive value 88.2%. Copyright © 2014 Elsevier GmbH. All rights reserved.

75 FR 34705 - Information Collection; Submission for OMB Review, Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... respond, including the use of appropriate automated, electronic, mechanical, or other technological... Progress Report was published in the Federal Register on March 12, 2010. This comment period ended on May... encouraged the Corporation to retain the current Progress Report submission schedule of semi-annually to help...

Understanding Your Adequate Yearly Progress (AYP), 2011-2012

ERIC Educational Resources Information Center

Missouri Department of Elementary and Secondary Education, 2011

2011-01-01

The "No Child Left Behind Act (NCLB) of 2001" requires all schools, districts/local education agencies (LEAs) and states to show that students are making Adequate Yearly Progress (AYP). NCLB requires states to establish targets in the following ways: (1) Annual Proficiency Target; (2) Attendance/Graduation Rates; and (3) Participation…

National Disability Policy: A Progress Report

ERIC Educational Resources Information Center

National Council on Disability, 2008

2008-01-01

This National Council on Disability (NCD) annual progress report to the President and Congress covers the period December 2005 through December 2006. The report is divided into 13 chapters, each dealing with a major area of public policy. These subject-specific chapters are preceded by an introductory Major Trends section that identifies…

Biology Division annual progress report for period ending December 31, 1968

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1969-07-01

Brief summaries are presented of research in progress in the fields of radiobiology, genetics, hematology, immunology, physsiology, biochemistry, bacteriology, enzymology, microbiology, photosynthesis, biophysics, radiation protection, and related fields. A list is included of 212 publications in the world literature that report results of completed studies. (CH)

Research on Speech Perception. Progress Report No. 4, January 1977-September 1978.

ERIC Educational Resources Information Center

Pisoni, David B.; And Others

Summarizing research activities from January 1977 to September 1978, this is the fourth annual report of research on speech processing conducted in the Department of Psychology at Indiana University. The report includes extended manuscripts, short reports, progress reports, and information on instrumentation developments and software support. The…

Annual progress report : for the period of January 2001 through December 2001 : Florida Transit Training Program (2001) : Florida Technical Assistance Program (2001)

DOT National Transportation Integrated Search

2001-01-01

The following progress report is intended to highlight the significant activities of the Florida Transit Training Program and Florida Technical Assistant Program for the 2001 year. Activities of the Florida Statewide Transit Training Program are pres...

Early In Vitro Differentiation of Mouse Definitive Endoderm Is Not Correlated with Progressive Maturation of Nuclear DNA Methylation Patterns

PubMed Central

Tajbakhsh, Jian; Gertych, Arkadiusz; Fagg, W. Samuel; Hatada, Seigo; Fair, Jeffrey H.

2011-01-01

The genome organization in pluripotent cells undergoing the first steps of differentiation is highly relevant to the reprogramming process in differentiation. Considering this fact, chromatin texture patterns that identify cells at the very early stage of lineage commitment could serve as valuable tools in the selection of optimal cell phenotypes for regenerative medicine applications. Here we report on the first-time use of high-resolution three-dimensional fluorescence imaging and comprehensive topological cell-by-cell analyses with a novel image-cytometrical approach towards the identification of in situ global nuclear DNA methylation patterns in early endodermal differentiation of mouse ES cells (up to day 6), and the correlations of these patterns with a set of putative markers for pluripotency and endodermal commitment, and the epithelial and mesenchymal character of cells. Utilizing this in vitro cell system as a model for assessing the relationship between differentiation and nuclear DNA methylation patterns, we found that differentiating cell populations display an increasing number of cells with a gain in DNA methylation load: first within their euchromatin, then extending into heterochromatic areas of the nucleus, which also results in significant changes of methylcytosine/global DNA codistribution patterns. We were also able to co-visualize and quantify the concomitant stochastic marker expression on a per-cell basis, for which we did not measure any correlation to methylcytosine loads or distribution patterns. We observe that the progression of global DNA methylation is not correlated with the standard transcription factors associated with endodermal development. Further studies are needed to determine whether the progression of global methylation could represent a useful signature of cellular differentiation. This concept of tracking epigenetic progression may prove useful in the selection of cell phenotypes for future regenerative medicine applications. PMID:21779341

Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.

PubMed

Liao, Zhiming; Wang, Shihua; Boileau, Thomas W-M; Erdman, John W; Clinton, Steven K

2005-07-01

Characterization of molecular events during N-methyl-N-nitrosourea (MNU)-induced rat prostate carcinogenesis enhances the utility of this model for the preclinical assessment of preventive strategies. Androgen independence is typical of advanced human prostate cancer and may occur through multiple mechanisms including the loss of androgen receptor (AR) expression and the activation of alternative signaling pathways. We examined the interrelationships between AR and p-AKT expression by immunohistochemical staining during MNU-androgen-induced prostate carcinogenesis in male Wistar-Unilever rats. Histone nuclear staining and image analysis was employed to assess parallel changes in chromatin and nuclear structure. The percentage of AR positive nuclei decreased (P < 0.01) as carcinogenesis progressed: hyperplasia (92%), atypical hyperplasia (92%), well-differentiated adenocarcinoma (57%), moderately-differentiated adenocarcinoma (19%), and poorly-differentiated adenocarcinoma (10%). Conversely, p-AKT staining increased significantly during carcinogenesis. Sparse staining was observed in normal tissues (0.2% of epithelial area) and hyperplastic lesions (0.1%), while expression increased significantly (P < 0.001) in atypical hyperplasia (7.6%), well-differentiated adenocarcinoma (16.7%), moderately-differentiated adenocarcinoma (19.6%), and poorly-differentiated adenocarcinoma (17.4%). In parallel, nuclear morphometry revealed increased nuclear size, greater irregularity, and lower DNA compactness as cancers became more poorly differentiated. In the MNU model, the progressive evolution of dominant tumor cell populations showing an increase in p-AKT in parallel with a decline in AR staining suggests that activation of AKT signaling may be one of several mechanisms contributing to androgen insensitivity during prostate cancer progression. Our observations mimic findings suggested by human studies and support the relevance of the MNU model in preclinical studies of preventive strategies. (c) 2005 Wiley-Liss, Inc.

TRACING CO-REGULATORY NETWORK DYNAMICS IN NOISY, SINGLE-CELL TRANSCRIPTOME TRAJECTORIES.

PubMed

Cordero, Pablo; Stuart, Joshua M

2017-01-01

The availability of gene expression data at the single cell level makes it possible to probe the molecular underpinnings of complex biological processes such as differentiation and oncogenesis. Promising new methods have emerged for reconstructing a progression 'trajectory' from static single-cell transcriptome measurements. However, it remains unclear how to adequately model the appreciable level of noise in these data to elucidate gene regulatory network rewiring. Here, we present a framework called Single Cell Inference of MorphIng Trajectories and their Associated Regulation (SCIMITAR) that infers progressions from static single-cell transcriptomes by employing a continuous parametrization of Gaussian mixtures in high-dimensional curves. SCIMITAR yields rich models from the data that highlight genes with expression and co-expression patterns that are associated with the inferred progression. Further, SCIMITAR extracts regulatory states from the implicated trajectory-evolvingco-expression networks. We benchmark the method on simulated data to show that it yields accurate cell ordering and gene network inferences. Applied to the interpretation of a single-cell human fetal neuron dataset, SCIMITAR finds progression-associated genes in cornerstone neural differentiation pathways missed by standard differential expression tests. Finally, by leveraging the rewiring of gene-gene co-expression relations across the progression, the method reveals the rise and fall of co-regulatory states and trajectory-dependent gene modules. These analyses implicate new transcription factors in neural differentiation including putative co-factors for the multi-functional NFAT pathway.

Building America Systems Integration Research Annual Report. FY 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gestwick, Michael

2013-05-01

This Building America FY2012 Annual Report includes an overview of the Building America Program activities and the work completed by the National Renewable Energy Laboratory and the Building America industry consortia (the Building America teams). The annual report summarizes major technical accomplishments and progress towards U.S. Department of Energy Building Technologies Program's multi-year goal of developing the systems innovations that enable risk-free, cost effective, reliable and durable efficiency solutions that reduce energy use by 30%-50% in both new and existing homes.

GSA committees: Progress through service the Annual Program Committee

USGS Publications Warehouse

Costa, J.E.

2007-01-01

The GSA's Annual Program Committee (APC) is directly responsible for the GSA's meeting and other responsibilities especially before the main event. It decides on the locations, the number and content of the technical sessions, annual membership surveys, hospitality for the guests, field trips and more. In addition, it pays significant attention to creative thinking about geoscience discoveries and directions as well as identify new and emerging areas of earth science. APC is also looking for new ideas, approaches and directions.

The CERAD Neuropsychologic Battery Total Score and the progression of Alzheimer disease.

PubMed

Rossetti, Heidi C; Munro Cullum, C; Hynan, Linda S; Lacritz, Laura H

2010-01-01

To establish the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychologic battery as a valid measure of cognitive progression in Alzheimer disease (AD) by deriving annualized CERAD Total Change Scores and corresponding confidence intervals in AD and controls from which to define clinically meaningful change. Subjects included 383 normal control (NC) and 655 AD subjects with serial data from the CERAD registry database. Annualized CERAD Total Change Scores were derived and Reliable Change Indexes (RCIs) calculated to establish statistically reliable change values. CERAD Change Scores were compared with annualized change scores from the Mini-Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR) Sum of Boxes, and Blessed Dementia Rating Scale (BDRS). For the CERAD Total Score, the AD sample showed significantly greater decline than the NC sample over the 4-year interval, with AD subjects declining an average of 22.2 points compared with the NCs' improving an average 2.8 points from baseline to last visit [Group x Time interaction [F(4,1031)=246.08, P<0.001)]. By Visit 3, the majority of AD subjects (65.2%) showed a degree of cognitive decline that fell outside the RCI. CERAD Change Scores significantly correlated (P<0.001) with MMSE (r=-0.66), CDR (r=-0.42), and BDRS (r=-0.38) change scores. Results support the utility of the CERAD Total Score as a measure of AD progression and provide comparative data for annualized change in CERAD Total Score and other summary measures.

2014 Trans-Atlantic Research and Development Interchange ...

EPA Pesticide Factsheets

The Trans-Atlantic Research and Development Interchange on Sustainability (TARDIS) has been bringing together a select group of scientists and engineers for in-depth discussions on sustainability on a bi-annual basis since 2004. TARDIS 2014 included twenty eight individuals from across the globe discussing issues related to progress towards sustainability. The discussion included policies, technologies, societal structure and norms, business practices and culture, and time-frames. As discussed later, the focus was on four questions: (1) what progress has been accomplished in sustainability? (2) why has there not been more progress in moving societies towards sustainability? (3) what are the road-blocks to progress towards sustainability? (4) what are the policies, technologies, and other changes that are needed to make further progress towards sustainability? One salient conclusion from TARDIS 2014 is that while sustainability has entered mainstream thinking, significant social, economic, technological, and business barriers remain to further progress towards a sustainable path as discussed throughout this report. The Trans-Atlantic Research and Development Interchange on Sustainability is a bi-annual workshop alternatively held in the United States and Austria. The purpose is to bring the best thinkers from across the globe to discuss, explore, and clarify major issues related to sustainability. A report summarizing teh finding and discussions is prepared and d

Wage Equity and Female Faculty Job-Satisfaction: The Role of Wage Differentials in a Job Satisfaction Causal Model. ASHE Annual Meeting Paper.

ERIC Educational Resources Information Center

Hagedorn, Linda Serra

This study examined the role of female/male wage differentials in a model of job satisfaction. It is based on data from 5,021 respondents to the 1989 Carnegie Foundation for the Advancement of Teaching national faculty survey. The model considers the interrelated effects of the calculated wage differential, stress, social perceptions of students,…

Longitudinal follow-up study of smoking-induced emphysema progression in low-dose CT screening of lung cancer

NASA Astrophysics Data System (ADS)

Suzuki, H.; Matsuhiro, M.; Kawata, Y.; Niki, N.; Nakano, Y.; Ohmatsu, H.; Kusumoto, M.; Tsuchida, T.; Eguchi, K.; Kaneko, Masahiro; Moriyama, N.

2014-03-01

Chronic obstructive pulmonary disease is a major public health problem that is predicted to be third leading cause of death in 2030. Although spirometry is traditionally used to quantify emphysema progression, it is difficult to detect the loss of pulmonary function by emphysema in early stage, and to assess the susceptibility to smoking. This study presents quantification method of smoking-induced emphysema progression based on annual changes of low attenuation volume (LAV) by each lung lobe acquired from low-dose CT images in lung cancer screening. The method consists of three steps. First, lung lobes are segmented using extracted interlobar fissures by enhancement filter based on fourdimensional curvature. Second, LAV of each lung lobe is segmented. Finally, smoking-induced emphysema progression is assessed by statistical analysis of the annual changes represented by linear regression of LAV percentage in each lung lobe. This method was applied to 140 participants in lung cancer CT screening for six years. The results showed that LAV progressions of nonsmokers, past smokers, and current smokers are different in terms of pack-year and smoking cessation duration. This study demonstrates effectiveness in diagnosis and prognosis of early emphysema in lung cancer CT screening.

ERIC Annual Report, 1999: Summarizing the Recent Accomplishments of the Educational Resources Information Center.

ERIC Educational Resources Information Center

Smarte, Lynn

This 1999 annual report, summarizing the accomplishments of the Educational Resources Information System (ERIC) system in 1998, begins with a section that highlights progress towards meeting goals, as well as selected statistics. The second section, comprising the bulk of the report, provides an overview of ERIC, including the ERIC database, user…

ERIC Annual Report, 2000: Summarizing the Recent Accomplishments of the Educational Resources Information Center.

ERIC Educational Resources Information Center

Smarte, Lynn

This 2000 annual report, summarizing the accomplishments of the Educational Resources Information Center (ERIC) system in 1999, begins with a section that highlights progress towards meeting goals, as well as selected statistics. The second section, comprising the bulk of the report, provides an overview of ERIC, including the ERIC database, user…

75 FR 968 - Notice of Public Information Collections Being Reviewed by the U.S. Agency for International...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... [email protected] . SUPPLEMENTARY INFORMATION: OMB No.: OMB 0412-New. Form No.: N/A. Title: Mentor-Prot[eacute]g[eacute] Program Annual Report. Type of Review: New. Purpose: The mentors are required to report on the progress made under each of active Mentor-Prot[eacute]g[eacute] Agreement annually throughout...

Continuous Improvement: Building for the Future. Superintendent's 20th Annual Report, 2009

ERIC Educational Resources Information Center

State of Hawaii Department of Education, 2009

2009-01-01

This paper presents the Superintendent's 20th Annual Report, a comprehensive overview of Hawaii's public schools for school year 2008-09. This report contains essential progress indicators and measures, as well as highlights and comparisons of core educational data presented in a concise and user-friendly format. Appended are: (1) Glossary; (2)…

Missouri Coordinating Board for Higher Education Fiscal Year 2005 Annual Report

ERIC Educational Resources Information Center

Fitch, Gregory G.; Stein, Robert; Matchefts, Jim; Peterson, Dan; Imhoff, Donna; Miner, Brenda; Fennewald, Amy

2005-01-01

The Coordinating Board for Higher Education and the Missouri Department of Higher Education present this fiscal year 2005 Annual Report to inform individuals of the state's status and progress in higher education. The Coordinating Board for Higher Education (CBHE) began the 2005 calendar year with a number of significant changes. The board and its…

The Annual Review of Information Science and Technology: Its Aims and Impact.

ERIC Educational Resources Information Center

Cuadra, Carlos A.

The major aims of the "Annual Review of Information Science and Technology" are (1) to describe and appraise progress in information science and technology; (2) to provide a systematic, dependable tool that can relieve professionals from winnowing through a wealth of literature in their field each year; (3) to direct the reader to…

The State of the Cities, 1999. Third Annual Report.

ERIC Educational Resources Information Center

Department of Housing and Urban Development, Washington, DC. Office of Policy Development and Research.

This third annual report discusses recent progress and challenges that lie ahead for U.S. cities and metropolitan regions. Part 1 examines social and economic trends affecting U.S. cities and the potential for a city/suburb alliance to promote a common agenda that would address the challenges and seize the opportunities reflected in the trends.…

Identification of differentially expressed proteins during human urinary bladder cancer progression.

PubMed

Memon, Ashfaque A; Chang, Jong W; Oh, Bong R; Yoo, Yung J

2005-01-01

Comparative proteome analysis was performed between RT4 (grade-1) and T24 (grade-3) bladder cancer cell lines, in an attempt to identify differentially expressed proteins during bladder cancer progression. Among those relatively abundant proteins, seven spots changed more than two-fold reproducibly and identified by peptide mass fingerprinting using mass spectrometry and database search. We found most extensive and reproducible down-regulation of NADP dependent isocitrate dehydrogenase cytoplasmic (IDPc) and peroxiredoxin-II (Prx-II), in poorly differentiated T24 compared to well-differentiated RT4 bladder cancer cell line. Subsequent Western blotting analysis of human biopsy samples from bladder cancer patient revealed significant loss of IDPc and Prx-II in more advance tumor samples, in agreement with data on cell lines. These results suggest that loss of IDPc and Prx-II during tumor development may involve in tumor progression and metastasis. However, additional investigations are needed on large number of human samples to further verify these findings.

Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis.

PubMed

Goodwin, Justin; Choi, Hyunsung; Hsieh, Meng-Hsiung; Neugent, Michael L; Ahn, Jung-Mo; Hayenga, Heather N; Singh, Pankaj K; Shackelford, David B; Lee, In-Kyu; Shulaev, Vladimir; Dhar, Shanta; Takeda, Norihiko; Kim, Jung-Whan

2018-02-01

Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how various microenvironmental influences, such as hypoxia, contribute to their sustained activation and differentiation is poorly understood. As a defining feature of hypoxia is its impact on cellular metabolism, we sought to investigate how hypoxia-induced metabolic reprogramming affects myofibroblast differentiation and fibrotic progression, and to test the preclinical efficacy of targeting glycolytic metabolism for the treatment of pulmonary fibrosis. Bleomycin-induced pulmonary fibrotic progression was evaluated in two independent, fibroblast-specific, promoter-driven, hypoxia-inducible factor (Hif) 1A knockout mouse models and in glycolytic inhibitor, dichloroacetate-treated mice. Genetic and pharmacological approaches were used to explicate the role of metabolic reprogramming in myofibroblast differentiation. Hypoxia significantly enhanced transforming growth factor-β-induced myofibroblast differentiation through HIF-1α, whereas overexpression of the critical HIF-1α-mediated glycolytic switch, pyruvate dehydrogenase kinase 1 (PDK1) was sufficient to activate glycolysis and potentiate myofibroblast differentiation, even in the absence of HIF-1α. Inhibition of the HIF-1α/PDK1 axis by genomic deletion of Hif1A or pharmacological inhibition of PDK1 significantly attenuated bleomycin-induced pulmonary fibrosis. Our findings suggest that HIF-1α/PDK1-mediated glycolytic reprogramming is a critical metabolic alteration that acts to promote myofibroblast differentiation and fibrotic progression, and demonstrate that targeting glycolytic metabolism may prove to be a potential therapeutic strategy for the treatment of pulmonary fibrosis.

AB72. Mysteries of TGF-β paradox in benign and malignant cells

PubMed Central

Lee, Chung; Grayhack, John T.

2014-01-01

TGF-β regulates a wide range of biological functions including embryonic development, wound healing, organogenesis, immune modulation, and cancer progression. Interestingly, TGF-β is known to inhibit cell growth in benign cells but promote progression in cancer cells, a phenomenon known as TGF-β paradox. To date, the mechanism of this paradox still remains as a scientific mystery. In this review, we present our experience, alone with the literature, in an attempt to offer answers to this mystery. First, we observed that, upon TGF-β engagement, there is a differential activation of Erk between benign and cancer cells. Since activated Erk is a major mediator in tumor progression and metastasis, a differentially activated Erk represents the answer to this mystery. Second, we identified a key player, PP2A-B56α, which is differentially recruited by the activated type I TGF-β receptor (TBRI) in benign and tumor cells, resulting in differential Erk activation. Finally, TGF-β stimulation leads to a suppressed TBRs in tumor cells but not in benign cells. This differentially suppressed TBRs triggers differential recruitment of PP2A-B56α and, thus, differential activation of Erk. The above three events offer the explanation to the mysteries of TGF-β paradox. Understanding the mechanism of TGF-β paradox will help us to predict indolent from aggressive cancers and will help us to develop novel anti-cancer strategies.

Mysteries of TGF-β Paradox in Benign and Malignant Cells.

PubMed

Zhang, Qiang; Yu, Nengwang; Lee, Chung

2014-01-01

TGF-β regulates a wide range of biological functions including embryonic development, wound healing, organogenesis, immune modulation, and cancer progression. Interestingly, TGF-β is known to inhibit cell growth in benign cells but promote progression in cancer cells; this phenomenon is known as TGF-β paradox. To date, the mechanism of this paradox still remains a scientific mystery. In this review, we present our experience, along with the literature, in an attempt to answer this mystery. First, we observed that, on TGF-β engagement, there is a differential activation of Erk between benign and cancer cells. Since activated Erk is a major mediator in tumor progression and metastasis, a differentially activated Erk represents the answer to this mystery. Second, we identified a key player, PP2A-B56α, which is differentially recruited by the activated type I TGF-β receptor (TBRI) in benign and tumor cells, resulting in differential Erk activation. Finally, TGF-β stimulation leads to suppressed TBRs in tumor cells but not in benign cells. This differentially suppressed TBRs triggers differential recruitment of PP2A-B56α and, thus, differential activation of Erk. The above three events explain the mysteries of TGF-β paradox. Understanding the mechanism of TGF-β paradox will help us to predict indolent from aggressive cancers and develop novel anti-cancer strategies.

Mysteries of TGF-β Paradox in Benign and Malignant Cells

PubMed Central

Zhang, Qiang; Yu, Nengwang; Lee, Chung

2014-01-01

TGF-β regulates a wide range of biological functions including embryonic development, wound healing, organogenesis, immune modulation, and cancer progression. Interestingly, TGF-β is known to inhibit cell growth in benign cells but promote progression in cancer cells; this phenomenon is known as TGF-β paradox. To date, the mechanism of this paradox still remains a scientific mystery. In this review, we present our experience, along with the literature, in an attempt to answer this mystery. First, we observed that, on TGF-β engagement, there is a differential activation of Erk between benign and cancer cells. Since activated Erk is a major mediator in tumor progression and metastasis, a differentially activated Erk represents the answer to this mystery. Second, we identified a key player, PP2A-B56α, which is differentially recruited by the activated type I TGF-β receptor (TBRI) in benign and tumor cells, resulting in differential Erk activation. Finally, TGF-β stimulation leads to suppressed TBRs in tumor cells but not in benign cells. This differentially suppressed TBRs triggers differential recruitment of PP2A-B56α and, thus, differential activation of Erk. The above three events explain the mysteries of TGF-β paradox. Understanding the mechanism of TGF-β paradox will help us to predict indolent from aggressive cancers and develop novel anti-cancer strategies. PMID:24860782

Restaging after neoadjuvant chemoradiation in rectal cancers: is histology the key in patient selection?

PubMed Central

Singhal, Nitin; Vallam, Karthik; Engineer, Reena; Ostwal, Vikas; Arya, Supreeta

2016-01-01

Background Neoadjuvant chemoradiation is the standard of care for locally advanced rectal cancer. However, there is no clarity regarding the necessity for restaging scans to rule out systemic progression of disease post chemoradiation with existing literature being divided on the need for the same. Methods Data from a prospectively maintained database was retrospectively analysed. All locally advanced rectal cancers (node positive/T4/T3 with threatened or involved CRM) were included. Biopsy proof of adenocarcinoma and CT scan of abdomen and chest were mandatory. Grade of tumor and response to CTRT on restaging magnetic resonance imaging (MRI) were documented. Results Out of 119 patients subjected to CTRT, 72 underwent definitive total mesorectal excision while 13 patients progressed locoregionally on restaging MR pelvis and 15 other patients progressed systemically while the rest defaulted. Patients with poorly differentiated (PD) cancers were compared to those with well/moderately differentiated (WMD) tumors. PD tumors had a significantly higher rate of local progression (32.1% vs. 5.6% %, P=0.0011) and systemic progression (35.7% vs. 6.9%, P=0.0008) as compared to WMD tumors. Only one-third (9/28) of PD patients underwent TME while the rest progressed. Conclusions Selecting poorly differentiated tumors alone for restaging CECT abdomen and thorax will be a cost effective strategy as the rate of progression is very high. Also patients with PD tumors need to be consulted about the high probability of progression of disease. PMID:27284467

True progression versus pseudoprogression in the treatment of glioblastomas: a comparison study of normalized cerebral blood volume and apparent diffusion coefficient by histogram analysis.

PubMed

Song, Yong Sub; Choi, Seung Hong; Park, Chul-Kee; Yi, Kyung Sik; Lee, Woong Jae; Yun, Tae Jin; Kim, Tae Min; Lee, Se-Hoon; Kim, Ji-Hoon; Sohn, Chul-Ho; Park, Sung-Hye; Kim, Il Han; Jahng, Geon-Ho; Chang, Kee-Hyun

2013-01-01

The purpose of this study was to differentiate true progression from pseudoprogression of glioblastomas treated with concurrent chemoradiotherapy (CCRT) with temozolomide (TMZ) by using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. Twenty patients with histopathologically proven glioblastoma who had received CCRT with TMZ underwent perfusion-weighted imaging and diffusion-weighted imaging (b = 0, 1000 sec/mm(2)). The corresponding nCBV and ADC maps for the newly visible, entirely enhancing lesions were calculated after the completion of CCRT with TMZ. Two observers independently measured the histogram parameters of the nCBV and ADC maps. The histogram parameters between the true progression group (n = 10) and the pseudoprogression group (n = 10) were compared by use of an unpaired Student's t test and subsequent multivariable stepwise logistic regression analysis to determine the best predictors for the differential diagnosis between the two groups. Receiver operating characteristic analysis was employed to determine the best cutoff values for the histogram parameters that proved to be significant predictors for differentiating true progression from pseudoprogression. Intraclass correlation coefficient was used to determine the level of inter-observer reliability for the histogram parameters. The 5th percentile value (C5) of the cumulative ADC histograms was a significant predictor for the differential diagnosis between true progression and pseudoprogression (p = 0.044 for observer 1; p = 0.011 for observer 2). Optimal cutoff values of 892 × 10(-6) mm(2)/sec for observer 1 and 907 × 10(-6) mm(2)/sec for observer 2 could help differentiate between the two groups with a sensitivity of 90% and 80%, respectively, a specificity of 90% and 80%, respectively, and an area under the curve of 0.880 and 0.840, respectively. There was no other significant differentiating parameter on the nCBV histograms. Inter-observer reliability was excellent or good for all histogram parameters (intraclass correlation coefficient range: 0.70-0.99). The C5 of the cumulative ADC histogram can be a promising parameter for the differentiation of true progression from pseudoprogression of newly visible, entirely enhancing lesions after CCRT with TMZ for glioblastomas.

True Progression versus Pseudoprogression in the Treatment of Glioblastomas: A Comparison Study of Normalized Cerebral Blood Volume and Apparent Diffusion Coefficient by Histogram Analysis

PubMed Central

Song, Yong Sub; Park, Chul-Kee; Yi, Kyung Sik; Lee, Woong Jae; Yun, Tae Jin; Kim, Tae Min; Lee, Se-Hoon; Kim, Ji-Hoon; Sohn, Chul-Ho; Park, Sung-Hye; Kim, Il Han; Jahng, Geon-Ho; Chang, Kee-Hyun

2013-01-01

Objective The purpose of this study was to differentiate true progression from pseudoprogression of glioblastomas treated with concurrent chemoradiotherapy (CCRT) with temozolomide (TMZ) by using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. Materials and Methods Twenty patients with histopathologically proven glioblastoma who had received CCRT with TMZ underwent perfusion-weighted imaging and diffusion-weighted imaging (b = 0, 1000 sec/mm2). The corresponding nCBV and ADC maps for the newly visible, entirely enhancing lesions were calculated after the completion of CCRT with TMZ. Two observers independently measured the histogram parameters of the nCBV and ADC maps. The histogram parameters between the true progression group (n = 10) and the pseudoprogression group (n = 10) were compared by use of an unpaired Student's t test and subsequent multivariable stepwise logistic regression analysis to determine the best predictors for the differential diagnosis between the two groups. Receiver operating characteristic analysis was employed to determine the best cutoff values for the histogram parameters that proved to be significant predictors for differentiating true progression from pseudoprogression. Intraclass correlation coefficient was used to determine the level of inter-observer reliability for the histogram parameters. Results The 5th percentile value (C5) of the cumulative ADC histograms was a significant predictor for the differential diagnosis between true progression and pseudoprogression (p = 0.044 for observer 1; p = 0.011 for observer 2). Optimal cutoff values of 892 × 10-6 mm2/sec for observer 1 and 907 × 10-6 mm2/sec for observer 2 could help differentiate between the two groups with a sensitivity of 90% and 80%, respectively, a specificity of 90% and 80%, respectively, and an area under the curve of 0.880 and 0.840, respectively. There was no other significant differentiating parameter on the nCBV histograms. Inter-observer reliability was excellent or good for all histogram parameters (intraclass correlation coefficient range: 0.70-0.99). Conclusion The C5 of the cumulative ADC histogram can be a promising parameter for the differentiation of true progression from pseudoprogression of newly visible, entirely enhancing lesions after CCRT with TMZ for glioblastomas. PMID:23901325

RISK FACTORS FOR NONREMISSION AND PROGRESSION-FREE SURVIVAL AFTER I-131 THERAPY IN PATIENTS WITH LUNG METASTASIS FROM DIFFERENTIATED THYROID CANCER: A SINGLE-INSTITUTE, RETROSPECTIVE ANALYSIS IN SOUTHERN CHINA.

PubMed

Chen, Pan; Feng, Hui-Juan; Ouyang, Wei; Wu, Ju-Qing; Wang, Jing; Sun, Yun-Gang; Xian, Jia-Lang; Huang, Liu-Hua

2016-09-01

Prognostic factors related to progression-free survival (PFS) have not received much attention in the literature regarding iodine-131 ((131)I) therapy for patients with differentiated thyroid cancer and lung metastases. We sought to explore the factors associated with PFS and nonremission in a group of patients with differentiated thyroid cancer and pulmonary metastases at initial diagnosis and to investigate the impact of (131)I therapy on pulmonary function and peripheral blood counts in the same cohort of patients. The medical records of 1,050 patients with differentiated thyroid cancer treated at the Zhujiang Hospital of Southern Medical University from January 2006 to January 2015 were retrospectively reviewed. Among them, 107 patients fulfilled the inclusion criteria. Multivariate Cox regression analysis indicated that age ≥45 years and (131)I nonavidity were independent risk factors for disease progression. Multivariate logistic regression analysis revealed that pulmonary nodule size ≥1 cm and (131)I nonavidity were the strongest risk factors predicting nonremission. Varying cumulative (131)I dosage had no association with posttreatment pulmonary function or peripheral blood cell counts. Similar to earlier studies, our results confirm that (131)I nonavidity was associated with an increased risk of disease progression and greater odds of nonremission. In addition, patients with differentiated thyroid cancer and lung metastases with pulmonary nodules ≥1 cm had a reduced likelihood of achieving remission. Furthermore, special attention is needed when monitoring patients over 45 years at a higher risk of disease progression. CI = confidence interval DTC = differentiated thyroid cancer (18)F-FDG = fluoro-18 fluorodeoxyglucose FEF = forced expiratory flow FTC = follicular thyroid cancer FVC = forced vital capacity GR = granulocytes Hb = hemoglobin HR = hazard ratio (131)I = iodine-131 LN = lymph node OR = odds ratio OS = overall survival PET/CT = positive positron emission tomography/computed tomography PFS = progression-free survival PT = partial thyroidectomy PTC = papillary thyroid cancer RAI = radioactive iodine RBC = red blood cell Tg = thyroglobulin TgAb = thyroglobulin antibody TSH = thyroid-stimulating hormone TT = total thyroidectomy WBC = white blood cells WBS = whole body scan.

Differential action of glycoprotein hormones: significance in cancer progression.

PubMed

Govindaraj, Vijayakumar; Arya, Swathy V; Rao, A J

2014-02-01

Growth of multicellular organisms depends on maintenance of proper balance between proliferation and differentiation. Any disturbance in this balance in animal cells can lead to cancer. Experimental evidence is provided to conclude with special reference to the action of follicle-stimulating hormone (FSH) on Sertoli cells, and luteinizing hormone (LH) on Leydig cells that these hormones exert a differential action on their target cells, i.e., stimulate proliferation when the cells are in an undifferentiated state which is the situation with cancer cells and promote only functional parameters when the cell are fully differentiated. Hormones and growth factors play a key role in cell proliferation, differentiation, and apoptosis. There is a growing body of evidence that various tumors express some hormones at high levels as well as their cognate receptors indicating the possibility of a role in progression of cancer. Hormones such as LH, FSH, and thyroid-stimulating hormone have been reported to stimulate cell proliferation and act as tumor promoter in a variety of hormone-dependent cancers including gonads, lung, thyroid, uterus, breast, prostate, etc. This review summarizes evidence to conclude that these hormones are produced by some cancer tissues to promote their own growth. Also an attempt is made to explain the significance of the differential action of hormones in progression of cancer with special reference to prostate cancer.

Adaptation to the Local Environment by Modifications of the Photoperiod Response in Crops

PubMed Central

Nakamichi, Norihito

2015-01-01

Flowering plants produce a meristem at the shoot tip where specialized tissue generates shoot apical meristems at the appropriate time to differentiate into reproductive structures, pollinate and efficiently generate seeds. The complex set of molecular and phenological events culminating in development of a flowering meristem is referred to as ‘flowering time’. Flowering time affects plant productivity because plants dedicate energy to produce flowers and seeds rather than vegetative tissue once the molecular decision to initiate flowering has been taken. Thus, initiation of flowering time is an important decision in plants, especially in annual plants including crops. Humans have introduced crops into latitudes and climate areas far from their origin or natural ecosystem, requiring in many cases modification of native flowering times. Recent molecular–genetic studies shed light on the genetic basis related to such introductions. In this review, recent progress regarding crop introductions and their genetic bases are summarized, as well as the potential of other agricultural plants to be introduced into different climatic zones. PMID:25432974

Temporal network analysis identifies early physiological and transcriptomic indicators of mild drought in Brassica rapa

PubMed Central

Gehan, Malia A; Mockler, Todd C; Weinig, Cynthia; Ewers, Brent E

2017-01-01

The dynamics of local climates make development of agricultural strategies challenging. Yield improvement has progressed slowly, especially in drought-prone regions where annual crop production suffers from episodic aridity. Underlying drought responses are circadian and diel control of gene expression that regulate daily variations in metabolic and physiological pathways. To identify transcriptomic changes that occur in the crop Brassica rapa during initial perception of drought, we applied a co-expression network approach to associate rhythmic gene expression changes with physiological responses. Coupled analysis of transcriptome and physiological parameters over a two-day time course in control and drought-stressed plants provided temporal resolution necessary for correlation of network modules with dynamic changes in stomatal conductance, photosynthetic rate, and photosystem II efficiency. This approach enabled the identification of drought-responsive genes based on their differential rhythmic expression profiles in well-watered versus droughted networks and provided new insights into the dynamic physiological changes that occur during drought. PMID:28826479

International VLBI Service for Geodesy and Astrometry: 1999 Annual Report

NASA Technical Reports Server (NTRS)

Vandenberg, Nancy R. (Editor)

1999-01-01

This volume of reports is the 1999 Annual Report of the International VLBI Service for Geodesy and Astrometry -IVS. The individual reports were contributed by VLBI groups in the international geodetic community who constitute the components of IVS. The 1999 Annual Report documents the work of the IVS components for the year ending March 1, 1999, the official inauguration date of IVS. As the newest of the space technique services, IVS decided to publish this Annual Report as a reference to our organization and its components. The entire contents of this Annual Report also appear on the IVS website at: http://ivscc.gsfc.nasa.gov/pub/arl999. The IVS 1999 Annual Report will be a valuable reference for information about IVS and its components. This Annual Report will serve as a baseline from which we can measure the anticipated progress of IVS in coming years.

Transitions Study of predictors of illness progression in young people with mental ill health: study methodology.

PubMed

Purcell, R; Jorm, A F; Hickie, I B; Yung, A R; Pantelis, C; Amminger, G P; Glozier, N; Killackey, E; Phillips, L; Wood, S J; Mackinnon, A; Scott, E; Kenyon, A; Mundy, L; Nichles, A; Scaffidi, A; Spiliotacopoulos, D; Taylor, L; Tong, J P Y; Wiltink, S; Zmicerevska, N; Hermens, Daniel; Guastella, Adam; McGorry, P D

2015-02-01

An estimated 75% of mental disorders begin before the age of 24 and approximately 25% of 13-24-year-olds are affected by mental disorders at any one time. To better understand and ideally prevent the onset of post-pubertal mental disorders, a clinical staging model has been proposed that provides a longitudinal perspective of illness development. This heuristic model takes account of the differential effects of both genetic and environmental risk factors, as well as markers relevant to the stage of illness, course or prognosis. The aim of the Transitions Study is to test empirically the assumptions that underpin the clinical staging model. Additionally, it will permit investigation of a range of psychological, social and genetic markers in terms of their capacity to define current clinical stage or predict transition from less severe or enduring to more severe and persistent stages of mental disorder. This paper describes the study methodology, which involves a longitudinal cohort design implemented within four headspace youth mental health services in Australia. Participants are young people aged 12-25 years who have sought help at headspace and consented to complete a comprehensive assessment of clinical state and psychosocial risk factors. A total of 802 young people (66% female) completed baseline assessments. Annual follow-up assessments have commenced. The results of this study may have implications for the way mental disorders are diagnosed and treated, and progress our understanding of the pathophysiologies of complex mental disorders by identifying genetic or psychosocial markers of illness stage or progression. © 2013 Wiley Publishing Asia Pty Ltd.

International VLBI Service for Geodesy and Astronomy

NASA Technical Reports Server (NTRS)

Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

2004-01-01

This volume of reports is the 2003 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2003 Annual Report documents the work of the IVS components for the calendar year 2003, our fifih year of existence. The reports describe changes, activities, and progress of the IVS. Many thanks to all IVS components who contributed to this Annual Report. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2OO3

International VLBI Service for Geodesy and Astrometry 2013 Annual Report

NASA Technical Reports Server (NTRS)

Baver, Karen D.; Behrend, Dirk; Armstrong, Kyla L.

2014-01-01

This volume of reports is the 2013 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2013 Annual Report documents the work of the IVS components for the calendar year 2013, our fifteenth year of existence. The reports describe changes, activities, and progress of the IVS. Many thanks to all IVS components who contributed to this Annual Report. With the exception of the first section and the last section, the contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2013.

International VLBI Service for Geodesy and Astrometry 2012 Annual Report

NASA Technical Reports Server (NTRS)

Baver, Karen D.; Behrend, Dirk; Armstrong, Kyla L.

2013-01-01

This volume of reports is the 2012 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2012 Annual Report documents the work of the IVS components for the calendar year 2012, our fourteenth year of existence. The reports describe changes, activities, and progress ofthe IVS. Many thanks to all IVS components who contributed to this Annual Report. With the exception of the first section and parts of the last section (described below), the contents of this Annual Report also appear on the IVS Web site athttp:ivscc.gsfc.nasa.gov/publications/ar2012

Association of Progression of Carotid Artery Wall Volume and Recurrent Transient Ischemic Attack or Stroke: A Magnetic Resonance Imaging Study.

PubMed

Lu, Mingming; Peng, Peng; Cui, Yuanyuan; Qiao, Huiyu; Li, Dongye; Cai, Jianming; Zhao, Xihai

2018-03-01

This study aimed to investigate the association between carotid plaque progression and subsequent recurrent events using magnetic resonance imaging. Sixty-three symptomatic patients with ipsilateral carotid atherosclerotic stenosis (30%-69% stenosis) determined by ultrasound underwent first and second carotid artery magnetic resonance imaging for carotid artery at baseline and ≥6 months after the first scan, respectively. All the patients had clinical follow-up after the second magnetic resonance scan for ≤5 years until the onset of recurrent transient ischemic attack or stroke. Presence/absence of carotid plaque compositional features, particularly intraplaque hemorrhage and fibrous cap rupture was identified. The annual progression of carotid wall volume between 2 magnetic resonance scans was measured. Univariate and multivariate Cox regression was used to calculate the hazard ratio and corresponding 95% confidence interval of carotid plaque features in discriminating recurrent events. Receiver-operating-characteristic-curve analysis was conducted to determine the area-under-the-curve of carotid plaque features in predicting recurrent events. Sixty-three patients (mean age: 66.5±10.0 years old; 54 males) were eligible for final statistics analysis. During a mean follow-up duration of 55.1±13.6 months, 14.3% of patients (n=9) experienced ipsilateral recurrent transient ischemic attack/stroke. The annual progression of carotid wall volume was significantly associated with recurrent events before (hazard ratio, 1.14 per 10 mm 3 ; 95% confidence interval, 1.02-1.27; P =0.019) and after (hazard ratio, 1.19 per 10 mm3; 95% confidence interval, 1.03-1.37; P =0.022) adjusted for confounding factors. In discriminating the recurrence of transient ischemia attack/stroke, receiver-operator curve analysis indicated that combined with annual progression of wall volume, there was a significant incremental improvement in the area-under-the-curve of intraplaque hemorrhage (area-under-the-curve: 0.69-0.81) and fibrous cap rupture (area-under-the-curve: 0.73-0.84). The annual progression of carotid wall volume is independently associated with recurrent ischemic cerebrovascular events, and this measurement has added value for intraplaque hemorrhage and fibrous cap rupture in predicting future events. © 2018 American Heart Association, Inc.

FY2017 Technology Integration Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The 2017 Technology Integration Annual Progress Report covers 27 multi-year projects funded by the Vehicle Technologies Office. The report includes information on 20 competitively awarded projects, ranging from training on alternative fuels and vehicles for first responders, to safety training and design for maintenance facilities housing gaseous fuel vehicles, to electric vehicle community partner programs. It also includes seven projects conducted by several of VTO’s national laboratory partners, Argonne National Laboratory, Oak Ridge National Laboratory and the National Renewable Energy Laboratory. These projects range from a Technical Assistance project for business, industry, government and individuals, to the EcoCar 3 Studentmore » Competition, and the Fuel Economy Information Project.« less

Departmental of Clinical Investigation: Annual Research Progress Report for Fiscal Year 1992. Volume 1

DTIC Science & Technology

1993-01-01

effect of cisapride on the symptoms of unexplained upper abdominal pain, nausea, vomiting, anorexia, early satiety, bloating/ distension in patients with...for 30 minutes following eccentric exercise will less the 3 indices of delayed-onset muscle soreness (DOMS): perceived muscular soreness, reduced...post-exercise and the Talag Pain Rating Scale will be used to assess muscular soreness. Progress: No progress report was furnished by the principal

Research on Automatic Classification, Indexing and Extracting. Annual Progress Report.

ERIC Educational Resources Information Center

Baker, F.T.; And Others

In order to contribute to the success of several studies for automatic classification, indexing and extracting currently in progress, as well as to further the theoretical and practical understanding of textual item distributions, the development of a frequency program capable of supplying these types of information was undertaken. The program…

Research on Speech Perception. Progress Report No. 8, January 1982-December 1982.

ERIC Educational Resources Information Center

Pisoni, David B.; And Others

Summarizing research activities from January 1982 to December 1982, this is the eighth annual report of research on speech perception, analysis and synthesis conducted in the Speech Research Laboratory of the Department of Psychology at Indiana University. The report includes extended manuscripts, short reports, progress reports, and information…

Building Scientific Confidence in Read-Across: Progress in using HT Data to inform Read-Across Performance (Toxicology Forum)

EPA Science Inventory

Presentation at the 41st Annual Winter Meeting of The Toxicology Forum - From Assay to Assessment: Incorporating High Throughput Strategies into Health and Safety Evaluations on Building Scientific Confidence in Read-Across: Progress in using HT Data to inform Read-Across Perfor...

Research on Speech Perception. Progress Report No. 9, January 1983-December 1983.

ERIC Educational Resources Information Center

Pisoni, David B.; And Others

Summarizing research activities from January 1983 to December 1983, this is the ninth annual report of research on speech perception, analysis and synthesis conducted in the Speech Research Laboratory of the Department of Psychology at Indiana University. The report includes extended manuscripts, short reports, and progress reports. The report…

Straight A's: Public Education Policy and Progress. Volume 6, Number 16

ERIC Educational Resources Information Center

Amos, Jason, Ed.

2006-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Paying Double: United States Spends Over $1.4 Billion Annually on Remedial Education for Recent High School…

Research on Spoken Language Processing. Progress Report No. 21 (1996-1997).

ERIC Educational Resources Information Center

Pisoni, David B.

This 21st annual progress report summarizes research activities on speech perception and spoken language processing carried out in the Speech Research Laboratory, Department of Psychology, Indiana University in Bloomington. As with previous reports, the goal is to summarize accomplishments during 1996 and 1997 and make them readily available. Some…

[Regulation of terpene metabolism]. Annual progress report, March 15, 1988--March 14, 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Croteau, R.

1989-12-31

Progress in understanding of the metabolism of monoterpenes by peppermint and spearmint is recorded including the actions of two key enzymes, geranyl pyrophosphate:limonene cyclase and a UDP-glucose dependent glucosyl transferase; concerning the ultrastructure of oil gland senescence; enzyme subcellular localization; regulation of metabolism; and tissue culture systems.

Workplace Charging Challenge Progress Update 2016: A New Sustainable Commute

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

In the 2016 Workplace Charging Challenge annual survey, partners shared for the how their efforts were making an impact in their communities and helped identify best practices for workplace charging. The Workplace Charging Challenge Progress Update highlights the findings from this survey and recognizes leading employers for their workplace charging efforts.

A Goal for North Carolina's Schools. First in America 2001 Progress Report.

ERIC Educational Resources Information Center

Cunningham, Elizabeth Kolb, Ed.; Thompson, Charles L., Ed.

This second annual report details North Carolina's performance and progress since 2000 in the five goal areas: high student performance; every child ready to learn; safe, orderly, and caring schools; quality teachers and administrators; and strong family, business, and community support. Over the years, North Carolina's education system has…

U.S. Department of Energy Workplace Charging Challenge - Progress Update 2016: A New Sustainable Commute

DOE Office of Scientific and Technical Information (OSTI.GOV)

In June 2016, the Workplace Charging Challenge distributed its third annual survey to 295 partners with the goal of tracking partners' progress and identifying trends in workplace charging. This document summarizes findings from the survey and highlights accomplishments of the EV Everywhere Workplace Charging Challenge.

Outcomes for Children Served through IDEA's Early Childhood Programs: 2014-15

ERIC Educational Resources Information Center

Early Childhood Technical Assistance Center, 2016

2016-01-01

In 2014-2015, children with delays or disabilities who received services under the Individuals with Disabilities Act (IDEA) showed greater than expected developmental progress. Many children exited the program functioning within age expectations, and most made progress. States' Part C and Part B Preschool programs report data annually on three…

PPARbeta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y.

PubMed

Di Loreto, S; D'Angelo, B; D'Amico, M A; Benedetti, E; Cristiano, L; Cinque, B; Cifone, M G; Cerù, M P; Festuccia, C; Cimini, A

2007-06-01

Neuroblastomas are pediatric tumors originating from immature neuroblasts in the developing peripheral nervous system. Differentiation therapies could help lowering the high mortality due to rapid tumor progression to advanced stages. Oleic acid has been demonstrated to promote neuronal differentiation in neuronal cultures. Herein we report on the effects of oleic acid and of a specific synthetic PPARbeta agonist on cell growth, expression of differentiation markers and on parameters responsible for the malignancy such as adhesion, migration, invasiveness, BDNF, and TrkB expression of SH-SY5Y neuroblastoma cells. The results obtained demonstrate that many, but not all, oleic acid effects are mediated by PPARbeta and support a role for PPARbeta in neuronal differentiation strongly pointing towards PPAR ligands as new therapeutic strategies against progression and recurrences of neuroblastoma.

Annual Progress Report, 1978. Southern Rural Development Center, Mississippi State University. SRDC Series Publication No. 28.

ERIC Educational Resources Information Center

Southern Rural Development Center, State College, MS.

Summarizing Southern Rural Development Center (SRDC) activities during the October 1977-September 1978 fiscal year, this fifth annual report indicates that with Title V funding SRDC has continued its efforts to bring research and extension personnel together to work on problems in rural development. Support for programs and research at land grant…

Annual Summary Report Calendar Year 2000 for the 100-HR-3, 100-KR-4, and 100-NR-2 Operable Units and Pump-and-Treat Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

G. B. Mitchem

2001-08-22

This annual progress and performance evaluation report discusses the groundwater remedial actions in the 100 Area, including the interim actions at the 100-HR-3 and 100-KR-4 Operable Units, and also discusses the expedited response action in the 100-NR-2 operable unit.

Annual Report of the Center for Research in Human Learning, 1967-68.

ERIC Educational Resources Information Center

Minnesota Univ., Minneapolis. Center for Research in Human Learning.

This document constitutes the narrative portion of the Annual Progress Report of the Center for Research in Human Learning for the period 15 June 1967 to 15 June 1968. It was submitted to the National Science Foundation, the National Institute of Child Health and Human Development, and the Graduate School of the University of Minnesota as an…

34th Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2012

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services, US Department of Education, 2014

2014-01-01

The 34th Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2012 describes our nation's progress in: (1) providing a free appropriate public education (FAPE) for all children with disabilities; (2) ensuring that the rights of children with disabilities and their parents are protected;…

35th Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2013

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services, US Department of Education, 2014

2014-01-01

The 35th Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2013 describes the nation's progress in (1) providing a free appropriate public education (FAPE) for all children with disabilities, (2) ensuring that the rights of children with disabilities and their parents are protected, (3)…

Ultra-Dense Quantum Communication Using Integrated Photonic Architecture: First Annual Report

DTIC Science & Technology

2011-08-24

REPORT Ultra-Dense Quantum Communication Using Integrated Photonic Architecture: First Annual Report 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: The...goal of this program is to establish a fundamental information-theoretic understand of quantum secure communication and to devise a practical...scalable implementation of quantum key distribution protocols in an integrated photonic architecture. We report our progress on experimental and

Graduation and Dropout Statistics Annual Report. Report to the Legislature [2016-17

ERIC Educational Resources Information Center

Weaver-Randall, Katie; Ireland, Lisa

2018-01-01

Under the guidelines of state law, RCW 28A.175.010, the Office of Superintendent of Public Instruction (OSPI) is required to report annually on the educational progress of public school students in grades 7-12. At the direction of the U.S. Department of Education, Washington uses the adjusted cohort graduation calculation to track a single cohort…

Ecological requirements for pallid sturgeon reproduction and recruitment in the Lower Missouri River: Annual report 2010

USGS Publications Warehouse

DeLonay, Aaron J.; Jacobson, Robert B.; Papoulias, Diana M.; Wildhaber, Mark L.; Chojnacki, Kimberly A.; Pherigo, Emily K.; Haas, Justin D.; Mestl, Gerald E.

2012-01-01

The Comprehensive Sturgeon Research Project is a multiyear, multiagency collaborative research framework developed to provide information to support pallid sturgeon recovery and Missouri River management decisions. The project strategy integrates field and laboratory studies of sturgeon reproductive ecology, early life history, habitat requirements, and physiology. The project scope of work is developed annually with cooperating research partners and in collaboration with the U.S. Army Corps of Engineers, Missouri River Recovery—Integrated Science Program. The research consists of several interdependent and complementary tasks that engage multiple disciplines. The research tasks in the 2010 scope of work primarily address spawning as a probable factor limiting pallid sturgeon survival and recovery, although limited pilot studies also have been initiated to examine the requirements of early life stages. The research is designed to inform management decisions affecting channel re-engineering, flow modification, and pallid sturgeon population augmentation on the Missouri River, and throughout the range of the species. Research and progress made through this project are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by the Comprehensive Sturgeon Research Project during 2010.

Ecological requirements for pallid sturgeon reproduction and recruitment in the Lower Missouri River: Annual report 2009

USGS Publications Warehouse

DeLonay, Aaron J.; Jacobson, Robert B.; Papoulias, Diana M.; Wildhaber, Mark L.; Chojnacki, Kimberly A.; Pherigo, Emily K.; Bergthold, Casey L.; Mestl, Gerald E.

2010-01-01

The Comprehensive Sturgeon Research Project is a multiyear, multiagency collaborative research framework developed to provide information to support pallid sturgeon recovery and Missouri River management decisions. The general Comprehensive Sturgeon Research Project strategy is to integrate field and laboratory studies of sturgeon reproductive ecology, habitat requirements, and physiology to produce a predictive understanding of sturgeon population dynamics. The project scope of work is developed annually with cooperating research partners and in collaboration with the U.S. Army Corps of Engineers, Missouri River Recovery-Integrated Science Program. The research consists of several interdependent and complementary research tasks engaging multiple disciplines that primarily address spawning as a probable limiting factor in reproduction and survival of the pallid sturgeon. The research is multifaceted and is designed to provide information needed for management decisions impacting habitat restoration, flow modification, and pallid sturgeon population augmentation on the Missouri River, and throughout the range of the species. Research activities and progress towards understanding of the species are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by Comprehensive Sturgeon Research Project during 2009.

Idas, a Novel Phylogenetically Conserved Geminin-related Protein, Binds to Geminin and Is Required for Cell Cycle Progression*

PubMed Central

Pefani, Dafni-Eleutheria; Dimaki, Maria; Spella, Magda; Karantzelis, Nickolas; Mitsiki, Eirini; Kyrousi, Christina; Symeonidou, Ioanna-Eleni; Perrakis, Anastassis; Taraviras, Stavros; Lygerou, Zoi

2011-01-01

Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellular localization. Idas does not associate with Cdt1 and prevents Geminin from binding to Cdt1 in vitro. Idas depletion from cells affects cell cycle progression; cells accumulate in S phase and are unable to efficiently progress to mitosis. Idas protein levels decrease in anaphase, whereas its overexpression causes mitotic defects. During development, we show that Idas exhibits high level expression in the choroid plexus and the cortical hem of the mouse telencephalon. Our data highlight Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development. PMID:21543332

Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.

PubMed

Pefani, Dafni-Eleutheria; Dimaki, Maria; Spella, Magda; Karantzelis, Nickolas; Mitsiki, Eirini; Kyrousi, Christina; Symeonidou, Ioanna-Eleni; Perrakis, Anastassis; Taraviras, Stavros; Lygerou, Zoi

2011-07-01

Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellular localization. Idas does not associate with Cdt1 and prevents Geminin from binding to Cdt1 in vitro. Idas depletion from cells affects cell cycle progression; cells accumulate in S phase and are unable to efficiently progress to mitosis. Idas protein levels decrease in anaphase, whereas its overexpression causes mitotic defects. During development, we show that Idas exhibits high level expression in the choroid plexus and the cortical hem of the mouse telencephalon. Our data highlight Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development.

Building America Systems Integration Research Annual Report: FY 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gestwick, M.

2013-05-01

This document is the Building America FY2012 Annual Report, which includes an overview of the Building America Program activities and the work completed by the National Renewable Energy Laboratory and the Building America industry consortia (the Building America teams). The annual report summarizes major technical accomplishments and progress towards U.S. Department of Energy Building Technologies Program's multi-year goal of developing the systems innovations that enable risk-free, cost effective, reliable and durable efficiency solutions that reduce energy use by 30%-50% in both new and existing homes.

Combined Diffusion Tensor Imaging and Apparent Transverse Relaxation Rate Differentiate Parkinson Disease and Atypical Parkinsonism.

PubMed

Du, G; Lewis, M M; Kanekar, S; Sterling, N W; He, L; Kong, L; Li, R; Huang, X

2017-05-01

Both diffusion tensor imaging and the apparent transverse relaxation rate have shown promise in differentiating Parkinson disease from atypical parkinsonism (particularly multiple system atrophy and progressive supranuclear palsy). The objective of the study was to assess the ability of DTI, the apparent transverse relaxation rate, and their combination for differentiating Parkinson disease, multiple system atrophy, progressive supranuclear palsy, and controls. A total of 106 subjects (36 controls, 35 patients with Parkinson disease, 16 with multiple system atrophy, and 19 with progressive supranuclear palsy) were included. DTI and the apparent transverse relaxation rate measures from the striatal, midbrain, limbic, and cerebellar regions were obtained and compared among groups. The discrimination performance of DTI and the apparent transverse relaxation rate among groups was assessed by using Elastic-Net machine learning and receiver operating characteristic curve analysis. Compared with controls, patients with Parkinson disease showed significant apparent transverse relaxation rate differences in the red nucleus. Compared to those with Parkinson disease, patients with both multiple system atrophy and progressive supranuclear palsy showed more widespread changes, extending from the midbrain to striatal and cerebellar structures. The pattern of changes, however, was different between the 2 groups. For instance, patients with multiple system atrophy showed decreased fractional anisotropy and an increased apparent transverse relaxation rate in the subthalamic nucleus, whereas patients with progressive supranuclear palsy showed an increased mean diffusivity in the hippocampus. Combined, DTI and the apparent transverse relaxation rate were significantly better than DTI or the apparent transverse relaxation rate alone in separating controls from those with Parkinson disease/multiple system atrophy/progressive supranuclear palsy; controls from those with Parkinson disease; those with Parkinson disease from those with multiple system atrophy/progressive supranuclear palsy; and those with Parkinson disease from those with multiple system atrophy; but not those with Parkinson disease from those with progressive supranuclear palsy, or those with multiple system atrophy from those with progressive supranuclear palsy. DTI and the apparent transverse relaxation rate provide different but complementary information for different parkinsonisms. Combined DTI and apparent transverse relaxation rate may be a superior marker for the differential diagnosis of parkinsonisms. © 2017 by American Journal of Neuroradiology.

Dose-dependent progression of parkinsonism in manganese-exposed welders

PubMed Central

Searles Nielsen, Susan; Criswell, Susan R.; Sheppard, Lianne; Seixas, Noah; Warden, Mark N.; Checkoway, Harvey

2017-01-01

Objective: To determine whether the parkinsonian phenotype prevalent in welders is progressive, and whether progression is related to degree of exposure to manganese (Mn)-containing welding fume. Methods: This was a trade union–based longitudinal cohort study of 886 American welding-exposed workers with 1,492 examinations by a movement disorders specialist, including 398 workers with 606 follow-up examinations up to 9.9 years after baseline. We performed linear mixed model regression with cumulative Mn exposure as the independent variable and annual change in Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3) as the primary outcome, and subcategories of the UPDRS3 as secondary outcomes. The primary exposure metric was cumulative Mn exposure in mg Mn/m3-year estimated from detailed work histories. Results: Progression of parkinsonism increased with cumulative Mn exposure. Specifically, we observed an annual change in UPDRS3 of 0.24 (95% confidence interval 0.10–0.38) for each mg Mn/m3-year of exposure. Exposure was most strongly associated with progression of upper limb bradykinesia, upper and lower limb rigidity, and impairment of speech and facial expression. The association between welding exposure and progression appeared particularly marked in welders who did flux core arc welding in a confined space or workers whose baseline examination was within 5 years of first welding exposure. Conclusions: Exposure to Mn-containing welding fume may cause a dose-dependent progression of parkinsonism, especially upper limb bradykinesia, limb rigidity, and impairment of speech and facial expression. PMID:28031394

Constitutive Uncoupling of Pathways of Gene Expression That Control Growth and Differentiation in Myeloid Leukemia: A Model for the Origin and Progression of Malignancy

NASA Astrophysics Data System (ADS)

Sachs, Leo

1980-10-01

Chemical carcinogens and tumor promoters have pleiotropic effects. Tumor initiators can produce a variety of mutations and tumor promoters can regulate a variety of physiological molecules that control growth and differentiation. The appropriate mutation and the regulation of the appropriate molecules to induce cell growth can initiate and promote the sequence of changes required for transformation of normal cells into malignant cells. After this sequence of changes, some tumors can still be induced to revert with a high frequency from a malignant phenotype to a nonmalignant phenotype. Results obtained from analysis of regulation of growth and differentiation in normal and leukemic myeloid cells, the phenotypic reversion of malignancy by induction of normal differentiation in myeloid leukemia, and the blocks in differentiation-defective leukemic cell mutants have been used to propose a general model for the origin and progression of malignancy. The model states that malignancy originates by changing specific pathways of gene expression required for growth from inducible to constitutive in cells that can still be induced to differentiate normally by the physiological inducer of differentiation. The malignant cells, unlike the normal cells, then no longer require the physiological inducer for growth. This changes the requirements for growth and uncouples growth from differentiation. Constitutive expression of other specific pathways can uncouple other controls, which then causes blocks in differentiation and the further progression of malignancy. The existence of specific constitutive pathways of gene expression that uncouple controls in malignant cells can also explain the expression of fetal proteins, hormones, and some other specialized products of normal development in various types of tumors.

English Language Learners and Their Academic Progress: 2010-2011

ERIC Educational Resources Information Center

Shneyderman, Aleksandr

2012-01-01

This is the 2010-11 annual report on the academic progress of English language learners in the Miami-Dade County Public Schools. The purpose of the report is to: (1) Describe the demographic characteristics of students classified as English Language Learners (ELL) in the Miami-Dade County Public Schools (M-DCPS); (2) Provide data regarding ELL…

Progress toward Implementation of the Education for Employment Policy. 1987-88. ICoVE Survey Report. Report 20.

ERIC Educational Resources Information Center

Piland, Joseph; And Others

During the annual convention of the Illinois Vocational Association, a survey was conducted to determine perceptions about progress being made toward implementation of the Education for Employment (EFE) policy. Questions focused on four perceptions held by the EFE community about the needed changes: knowledge and awareness of expected changes;…

Vision for the Future of FIA: Paean to Progress, Possibilities, and Partners

Treesearch

Susan L. King; Charles T. Scott

2006-01-01

The Forest Inventory and Analysis (FIA) program of the U.S. Department of Agriculture Forest Service has made significant progress implementing the annualized inventory in 46 States in 2004. Major increases in program performance included the availability of plot data and the plots? corresponding approximate coordinates. A mill site study and biomass models were used...

Year 3 Magnet Schools Assistance Program Annual Progress Report, 2009-10. E&R Report No. 10.09

ERIC Educational Resources Information Center

Brasfield, Jon; Cárdenas, Virginia

2010-01-01

The three Magnet Schools Assistance Program (MSAP) schools: East Garner International Baccalaureate Magnet Middle School (EGMMS), Garner International Baccalaureate Magnet High School (GMHS), and Southeast Raleigh Leadership and Technology Magnet High School (SRMHS) have shown progress on MSAP performance measures during the 3rd year of the grant.…

Annual Technical Progress Report for Emergency School Assistance Program, Title 45, 1970-71.

ERIC Educational Resources Information Center

Lindsey, Randall B.

This paper presents a technical progress report of two programs conducted with funds provided under the Emergency School Assistance Program. One, the Mobile Learning Unit, said to have been designed to measure changes in fourth and fifth grade students' self-concept in a reorganized desegregated school environment, focuses on whether a positive…

Aspirations, Progress and Perceptions of Boys from a Single Sex School Following the Changeover to Coeducation

ERIC Educational Resources Information Center

Yates, Shirley M.

2004-01-01

Career and further education aspirations, educational progress and perceptions of the learning environment were measured annually over three years in primary and secondary boys from a single sex non-government school, following the changeover to coeducation. Hierarchical Linear Modelling analyses revealed the significant role played by the career…

Differential subjective responsiveness to a future cigarette price increase among South Korean youth smokers.

PubMed

Do, Young Kyung; Farooqui, Muhammad Assad

2012-02-01

While higher sensitivity to tobacco price increases among younger smokers as a group has been well recognized, little information is available on heterogeneity among youth smokers. This study examined differential responsiveness to an unspecified future cigarette price increase by smoking rate. This study used a subsample of 6,187 current youth smokers derived from the 2007 Korea Youth Health Survey, an annually repeated cross-sectional survey designed to monitor adolescent health behaviors in a large nationally representative sample of middle-school and high-school students in South Korea (N = 74,698). A generalized ordered logit model was estimated to examine independent associations of self-reported responses to an unspecified future cigarette price increase with smoking rate and time since smoking initiation, after controlling for other individual and family characteristics. Higher smoking rates and longer time since smoking initiation were associated with a greater likelihood to continue smoking despite a future cigarette price increase. When these two factors were accounted for in the model, other individual characteristics were not statistically significant. Among youth smokers in South Korea, higher smoking rates were associated with lower self-reported responsiveness to a future cigarette price increase. Tobacco tax increases help prevent youth smokers from progressing to advanced stages of smoking, while certain subgroups of youth smokers, especially with nicotine dependence, may still need other effective cessation interventions.

California Energy Systems for the 21st Century 2016 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Randwyk, J.; Boutelle, A.; McClelland, C.

The California Energy Systems for the 21st Century (CES-21) Program is a public-private collaborative research and development program between the California Joint Utilities1 and Lawrence Livermore National Laboratory (LLNL). The purpose of this annual report is to provide the California Public Utilities Commission (CPUC or Commission) with a summary of the 2016 progress of the CES-21 Program.

Clinical Investigation Program Annual Progress Report

DTIC Science & Technology

1988-10-20

Presented: Interna- tional Symposium on Orthopedics, Mexico , September 1987. Publications: In preparation. 147 FAMC A.P.R. (RCS MED 300) Detail Summary...Infection: A Prospective Study. Presented: 2nd Annual Symposium of the Rocky Moun- tain Flow Cytometry Users Group, Albuquerque, New Mexico , 10-11...Podgore, COL, MC (9) Dept/ISvc: Pediatrics (10) Associate Investigators (11) Key Words: Myron J. Levin, M.D. varicella vaccine U Co. HSC (12

Oregon Schools for the 21st Century: Oregon Report Card 1993-94. An Annual Report to the State Legislature on Oregon's Public Schools.

ERIC Educational Resources Information Center

Oregon State Dept. of Education, Salem.

The Oregon Report Card is an annual portrait of the state's public schools. The first five sections describe statewide progress toward implementing Oregon's Educational Act for the 21st Century, some of the state's exemplary school-improvement programs, and the clear relationship between Oregon's program and national education goals. The remaining…

Annual National Report of the Australian Vocational Education and Training System, 2001. Volume 1: National Overview; Volume 2: Commonwealth, State & Territory Reports.

ERIC Educational Resources Information Center

Australian National Training Authority, Brisbane.

This document contains the first two volumes of a three-volume annual national report on Australia's vocational education and training (VET) system. Volume 1, which constitutes approximately 30% of the document, details progress in achieving the following national priorities: (1) a quality national training system that provides value for money…

Become One In A Million: Partnership Updates. Million Solar Roofs and Interstate Renewable Energy Council Annual Meeting, Washington, D.C., October 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tombari, C.

2005-09-01

The U.S. Department of Energy's Million Solar Roofs Initiative (MSR) is a unique public-private partnership aimed at overcoming market barriers for photovoltaics (PV), solar water heating, transpired solar collectors, solar space heating and cooling, and pool heating. This report contains annual progress reports from 866 partners across the United States.

Implementation of the Education of the Handicapped Act [Public Law 94-142]. Eleventh Annual Report to Congress.

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services (ED), Washington, DC. Div. of Innovation and Development.

The report documents the nation's progress in providing a free appropriate public education for all children with handicaps under the provisions of the Education for All Handicapped Children Act, Public Law 94-142. Chapter I presents national statistics reported annually by the states (e.g., a 1.6% increase in number of handicapped children served…

LVC Architecture Roadmap Implementation - Results of the First Two Years

DTIC Science & Technology

2012-03-01

NOTES Presented at the Simulation Interoperability Standards Organization?s (SISO) Spring Simulation Interoperability Workshop ( SIW ), 26-30 March...presented at the semi-annual Simulation Interoperability Workshops ( SIWs ) and the annual Interservice/Industry Training, Simulation & Education Conference...I/ITSEC), as well as other venues. For example, a full-day workshop on the initial progress of the effort was conducted at the 2010 Spring SIW [2

Strong genetic differentiation in the invasive annual grass Bromus tectorum across the Mojave-Great Basin ecological transition zone

Treesearch

Susan E. Meyer; Elizabeth A. Leger; Desiree R. Eldon; Craig E. Coleman

2016-01-01

Bromus tectorum, an inbreeding annual grass, is a dominant invader in sagebrush steppe habitat in North America. It is also common in warm and salt deserts, displaying a larger environmental tolerance than most native species. We tested the hypothesis that a suite of habitat-specific B. tectorum lineages dominates warm desert habitats. We sampled 30 B....

Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas.

PubMed

Mo, Qianxing; Nikolos, Fotis; Chen, Fengju; Tramel, Zoe; Lee, Yu-Cheng; Hayashi, Kazukuni; Xiao, Jing; Shen, Jianjun; Chan, Keith Syson

2018-05-01

Muscle-invasive bladder cancers (MIBCs) cause approximately 150 000 deaths per year worldwide. Survival for MIBC patients is heterogeneous, with no clinically validated molecular markers that predict clinical outcome. Non-MIBCs (NMIBCs) generally have favorable outcome; however, a portion progress to MIBC. Hence, development of a prognostic tool that can guide decision-making is crucial for improving clinical management of bladder urothelial carcinomas. Tumor grade is defined by pathologic evaluation of tumor cell differentiation, and it often associates with clinical outcome. The current study extrapolates this conventional wisdom and combines it with molecular profiling. We developed an 18-gene signature that molecularly defines urothelial cellular differentiation, thus classifying MIBCs and NMIBCs into two subgroups: basal and differentiated. We evaluated the prognostic capability of this "tumor differentiation signature" and three other existing gene signatures including the The Cancer Genome Atlas (TCGA; 2707 genes), MD Anderson Cancer Center (MDA; 2252 genes/2697 probes), and University of North Carolina at Chapel Hill (UNC; 47 genes) using five gene expression data sets derived from MIBC and NMIBC patients. All statistical tests were two-sided. The tumor differentiation signature demonstrated consistency and statistical robustness toward stratifying MIBC patients into different overall survival outcomes (TCGA cohort 1, P = .03; MDA discovery, P = .009; MDA validation, P = .01), while the other signatures were not as consistent. In addition, we analyzed the progression (Ta/T1 progressing to ≥T2) probability of NMIBCs. NMIBC patients with a basal tumor differentiation signature associated with worse progression outcome (P = .008). Gene functional term enrichment and gene set enrichment analyses revealed that genes involved in the biologic process of immune response and inflammatory response are among the most elevated within basal bladder cancers, implicating them as candidates for immune checkpoint therapies. These results provide definitive evidence that a biology-prioritizing clustering methodology generates meaningful insights into patient stratification and reveals targetable molecular pathways to impact future therapeutic approach.

FY2014 Energy Storage R&D Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Energy Storage subprogram in 2014. You can download individual sections at themore » following website, http://energy.gov/eere/vehicles/downloads/vehicle-technologies-office-2014-energy-storage-rd-annual-report.« less

Marine biomass program: plant breeding and genetics. Annual report, September 1984-December 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neushul, M.; Harger, B.W.W.; Lewis, R.J.

1986-03-01

By building on past efforts and adding to the data base that has been assembled, and through collaborative research with others, progress has been made toward the long-term goal of growing macroalgae in the sea as a future source of substitute natural gas. It is encouraging that the authors program is being emulated in Japan and Sweden, and that there is growing interest in using the unique GRI kelp seedstock collection by workers in Germany, Japan, Alaska, Oregon, California, and elsewhere. This annual report discusses progress made in propagating kelps, and the floating gulf-weed, Sargassum. Work on kelp genetics hasmore » revealed high levels of compatability between species and genera, based on 166 hybridization tests.« less

Incidence and progression of myopia and associated factors in urban school children in Delhi: The North India Myopia Study (NIM Study).

PubMed

Saxena, Rohit; Vashist, Praveen; Tandon, Radhika; Pandey, Ravindra M; Bhardawaj, Amit; Gupta, Vivek; Menon, Vimala

2017-01-01

To evaluate the incidence and progression of myopia and factors associated with progression of myopia in school going children in Delhi. Prospective longitudinal study of 10,000 school children aged 5 to 15 years screened after an interval of 1 year to identify new myopes (Spherical Equivalent≤ -0.5D) and progression of myopia in previously diagnosed myopic children. Association between risk factors and progression was analyzed using adjusted odds ratio. Of the 9,616 children re-screened (97.3% coverage), annual incidence of myopia was 3.4%with mean dioptric change of -1.09 ± 0.55. There was a significant higher incidence of myopia in younger children compared to older children (P = 0.012) and among girls compared to boys (P = 0.002). Progression was observed in 49.2%children with mean dioptric change of -0.27 ± 0.42 diopters. The demographic and behavioral risk factors were analyzed for children with progression (n = 629) and adjusted odds ratio values were estimated. Hours of reading-writing/week (p<0.001), use of computers/ video games (P<0.001) and watching television (P = 0.048) were significant risk factors for progression of myopia. Outdoor activities / time spent outdoors> 2 hours in a day were protective with an inverse association with progression of myopia (P< 0.001). Myopia is an important health issue in India and is associated with long hours of reading and screen time with use of computers and video games. An annual eye vision screening should be conducted, and outdoor activities be promoted to prevent the increase of myopia among school children.

The secret origins and surprising fates of pancreas tumors

PubMed Central

Bailey, Jennifer M.; DelGiorno, Kathleen E.; Crawford, Howard C.

2014-01-01

Pancreatic ductal adenocarcinoma (PDA) is especially deadly due to its recalcitrance to current therapies. One of the unique qualities of PDA that may contribute to this resistance is a striking plasticity of differentiation states starting at tumor formation and continuing throughout tumor progression, including metastasis. Here, we explore the earliest steps of tumor formation and neoplastic progression and how this results in a fascinating cellular heterogeneity that is probably critical for tumor survival and progression. We hypothesize that reinforcing differentiation pathways run awry or targeting morphologically and molecularly distinct tumor stem-like cells may hold promise for future treatments of this deadly disease. PMID:24583923

Sumoylation Dynamics During Keratinocyte Differentiation

PubMed Central

Deyrieux, Adeline F.; Rosas-Acosta, Germán; Ozbun, Michelle A.; Wilson, Van G.

2012-01-01

Summary SUMO modification regulates the activity of numerous transcription factors that have a direct role in cell cycle progression, apoptosis, cellular proliferation, and development, but its role in differentiation processes is less clear. Keratinocyte differentiation requires the coordinated activation of a series of transcription factors, and as several critical keratinocyte transcription factors are known to be SUMO substrates, we investigated the role of sumoylation in keratinocyte differentiation. In a human keratinocyte cell line model (HaCaT cells), calcium-induced differentiation led to the transient and coordinated transcriptional activation of the genes encoding critical sumoylation system components, including SAE1, SAE2, Ubc9, SENP1, Miz-1 (PIASxβ), SUMO2, and SUMO3. The increased gene expression resulted in higher levels of the respective proteins and changes in the pattern of sumoylated substrate proteins during the differentiation process. Similar to the HaCaT results, stratified human foreskin keratinocytes showed an upregulation of Ubc9 in the suprabasal layers. Lastly, abrogation of sumoylation by Gam1 expression severely disrupted normal HaCaT differentiation, consistent with an important role for sumoylation in the proper progression of this biological process. PMID:17164289

Nuclear Technology Division annual progress report for period ending June 30, 1972

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1972-10-01

This document is a report of progress on technical programs of the Nuclear Technology,Division of Aerojet Nuclear Company for FY 72 ending June 30, 1972. It contains abstracts or expansions of abstracts of papers which have been published within the year. In these cases, preprints or reprints of the articles available. Results of work in progress are also reported; since this work is of a preliminary nature, the authors should be contacted before including any reference to these works in other publications.

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0654 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE Oct 2017 2. REPORT TYPE Annual 3. DATES COVERED 30...Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT

Annual Report of the Secretary of Defense on Reserve Forces for Fiscal Year 1975

DTIC Science & Technology

1976-06-08

acquisition and distribution of equipment continued to be achieved. Progress was made in both filling uxisting shortfalls and in modernization and... progress of the KOTC flight instruction programs. vArmy Air Force Units Participating 200 56 161 Students Enrolled 412 436 2,036 Students Completed 321 361...Resurve Forces IV Current Status and Progress Made in 4 Strengthening the Reserve Components * A. General 4 1. 24 Division rorce 4 4ii 2. Total Force

Analysis of MYB oncogene in transformed adenoid cystic carcinomas reveals distinct pathways of tumor progression.

PubMed

Costa, Ana F; Altemani, Albina; García-Inclán, Cristina; Fresno, Florentino; Suárez, Carlos; Llorente, José L; Hermsen, Mario

2014-06-01

Adenoid cystic carcinomas can occasionally undergo dedifferentiation, a phenomenon also referred to as high-grade transformation. However, cases of adenoid cystic carcinomas have been described showing transformation to adenocarcinomas that are not poorly differentiated, indicating that high-grade transformation may not necessarily reflect a more advanced stage of tumor progression, but rather a transformation to another histological form, which may encompass a wide spectrum of carcinomas in terms of aggressiveness. The aim of this study was to gain more insight in the biology of this pathological phenomenon by means of genetic profiling of both histological components. Using microarray comparative genomic hybridization, we compared the genome-wide DNA copy-number changes of the conventional and transformed area of eight adenoid cystic carcinomas with high-grade transformation, comprising four with transformation into moderately differentiated adenocarcinomas and four into poorly differentiated carcinomas. In general, the poorly differentiated carcinoma cases showed a higher total number of copy-number changes than the moderately differentiated adenocarcinoma cases, and this correlated with a worse clinical course. Special attention was given to chromosomal translocation and protein expression of MYB, recently being considered to be an early and major oncogenic event in adenoid cystic carcinomas. Our data showed that the process of high-grade transformation is not always accompanied by an accumulation of genetic alterations; both conventional and transformed components harbored unique genetic alterations, which indicate a parallel progression. Our data further demonstrated that the MYB/NFIB translocation is not necessarily an early event or fundamental for the progression to adenoid cystic carcinoma with high-grade transformation.

Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells.

PubMed

Kryza, Thomas; Silva, Lakmali M; Bock, Nathalie; Fuhrman-Luck, Ruth A; Stephens, Carson R; Gao, Jin; Samaratunga, Hema; Lawrence, Mitchell G; Hooper, John D; Dong, Ying; Risbridger, Gail P; Clements, Judith A

2017-10-01

The reciprocal communication between cancer cells and their microenvironment is critical in cancer progression. Although involvement of cancer-associated fibroblasts (CAF) in cancer progression is long established, the molecular mechanisms leading to differentiation of CAFs from normal fibroblasts are poorly understood. Here, we report that kallikrein-related peptidase-4 (KLK4) promotes CAF differentiation. KLK4 is highly expressed in prostate epithelial cells of premalignant (prostatic intraepithelial neoplasia) and malignant lesions compared to normal prostate epithelia, especially at the peristromal interface. KLK4 induced CAF-like features in the prostate-derived WPMY1 normal stromal cell line, including increased expression of alpha-smooth muscle actin, ESR1 and SFRP1. KLK4 activated protease-activated receptor-1 in WPMY1 cells increasing expression of several factors (FGF1, TAGLN, LOX, IL8, VEGFA) involved in prostate cancer progression. In addition, KLK4 induced WPMY1 cell proliferation and secretome changes, which in turn stimulated HUVEC cell proliferation that could be blocked by a VEGFA antibody. Importantly, the genes dysregulated by KLK4 treatment of WPMY1 cells were also differentially expressed between patient-derived CAFs compared to matched nonmalignant fibroblasts and were further increased by KLK4 treatment. Taken together, we propose that epithelial-derived KLK4 promotes tumour progression by actively promoting CAF differentiation in the prostate stromal microenvironment. © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

Differential declines in syphilis-related mortality in the United States, 2000-2014.

PubMed

Barragan, Noel C; Moschetti, Kristin; Smith, Lisa V; Sorvillo, Frank; Kuo, Tony

2017-04-01

After reaching an all time low in 2000, the rate of syphilis in the United States has been steadily increasing. Parallel benchmarking of the disease's mortality burden has not been undertaken. Using ICD-10 classification, all syphilis-related deaths in the national Multiple Cause of Death dataset were examined for the period 2000-2014. Descriptive statistics and age-adjusted mortality rates were generated. Poisson regression was performed to analyze trends over time. A matched case-control analysis was conducted to assess the associations between syphilis-related deaths and comorbid conditions listed in the death records. A total of 1,829 deaths were attributed to syphilis; 32% (n = 593) identified syphilis as the underlying cause of death. Most decedents were men (60%) and either black (48%) or white (39%). Decedents aged ≥85 years had the highest average mortality rate (0.47 per 100,000 population; 95% confidence interval [CI], 0.42-0.52). For the sampled period, the average annual decline in mortality was -2.90% (95% CI, -3.93% to -1.87%). However, the average annual percent change varied across subgroups of interest. Declines in U.S. syphilis mortality suggest early detection and improved treatment access likely helped attenuate disease progression; however, increases in the disease rate since 2000 may be offsetting the impact of these advancements. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Clinical Investigation Program Annual Progress Report.

DTIC Science & Technology

1985-09-30

027 78/114 In Vitro Effect of Minoxidil on Collagen Produc- tion by Normal and Scleroderma Fibroblasts (C) (PR...effect of minoxidil on collagen production Dy normal and scleroderma fibroblasts. Previously titled: The use of minoxidil in treating progressive...Svc: (tO) Assoc Investigators: (11) Key Words: scleroderma, minoxidil Thomas P. O’Barr PhD, DAC fibroblasts, collagen Ellen Swanson MS, DAC Don

Comparative study of radiation, chemical, and aging effects on viral transformation. Annual progress report, 1975

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coggin, J.H. Jr.

Progress is reported on the following research projects: evaluation of isotopic antiglobulin test (IAT) to detect tumor associated antigens using antisera induced by x-irradiated tumor cells; development of cytotoxic antibody for embryonic antigens (EA); acrylamide gel cell culture assay for transformation; and evaluation of 3-MCA induced sarcomas for TSTA and cross-reacting antigens. (HLW)

Synergistic Action of FOXP3 and TSC1 Pathways During Tumor Progression

DTIC Science & Technology

2016-10-01

Tumor progression, Gene therapy, Transcriptional regulation, Post -translational modification ACCOMPLISHMENTS Our preliminary studies provide evidence...Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for...10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 11. SPONSOR/MONITOR’S REPORT

State of the World, 1985: A Worldwatch Institute Report on Progress toward a Sustainable Society.

ERIC Educational Resources Information Center

Brown, Lester R.; And Others

The second of a series of annual reports designed to provide a global assessment of progress toward a sustainable society, this publication monitors changes in the global resource base (land, water, energy, and biological support systems), focusing particularly on how these changes affect the economy. Included in the report are news on innovative…

Burn Treatment: Annual Research Progress Report.

DTIC Science & Technology

1975-06-30

in addition to direct or indirect measurements of blood pressure. Central venous pressures are measured relatively frequently and, on occasion, a... Central venous pressure assessment. 5. EKG. 46 I 6. Sponge weighing. 7. Measurement of urine output during surgery. B. RESPIRATION 1. Counting of...start a central venous line prior to adminis- tration of vasopressors. The patient became progressively more hypo- tensive and bradycardiac, which

Straight A's: Public Education Policy and Progress. Volume 12, Number 8

ERIC Educational Resources Information Center

Amos, Jason, Ed.

2012-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Tax Returns: On Tax Day 2012, a 90 Percent High School Graduation Rate Would Yield $1.8 Billion Annually in Additional Tax…

Development of an Applied Fisheries Science Program for Native Alaskans at Sheldon Jackson College (Sitka, Alaska). Second Progress Report, 1 July 1975.

ERIC Educational Resources Information Center

Poon, Derek

Covering the period January 1 through June 30, 1975, this second semi-annual report on the Applied Fishery Science Program operative at Sheldon Jackson College in Sitka, Alaska presents information regarding program progress and Alaska Native students involved in science education. Specifically, this report details: Planning and Coordination…

FY2016 Lightweight Materials Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Lightweight Materials research and development (R&D) area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing lightweight materials for passenger and commercial vehicles. This report describes the progress made on the research and development projects funded by the Lightweight Materials area.

Function of PTP1B in Neuroendocrine Differentiation of Prostate Cancer

DTIC Science & Technology

2008-01-01

Annual 3. DATES COVERED 1 JAN 2007 - 31 DEC 2007 4. TITLE AND SUBTITLE Function of PTP1B in Neuroendocrine Differentiation of Prostate Cancer 5a...particularly the relationship of PTP1B to IL-8 signaling through its receptors CXCR1 and CXCR2, to IGF-1 receptor signaling through PI3 kinase/AKT/mTOR pathway

International VLBI Service for Geodesy and Astrometry

NASA Technical Reports Server (NTRS)

Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

2001-01-01

This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2000 Annual Report documents the work of these IVS components over the period March 1, 1999, through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000.

Commissioner's Annual Report to the Education Committees of the Senate and General Assembly on Violence, Vandalism and Substance Abuse in New Jersey Public Schools, July 1, 2007 to June 30, 2008

ERIC Educational Resources Information Center

New Jersey Department of Education, 2009

2009-01-01

The Commissioner's annual report provides the Legislature with information reported by school districts concerning incidents of serious student misconduct grouped into the following four major reporting categories: violence, vandalism, weapons, and substance abuse. An analysis of trends yields indications of progress and of ongoing concern, and…

Commissioner's Annual Report to the Education Committees of the Senate and General Assembly on Violence, Vandalism and Substance Abuse in New Jersey Public Schools, July 1, 2008 to June 30, 2009

ERIC Educational Resources Information Center

New Jersey Department of Education, 2010

2010-01-01

The Commissioner's annual report provides the Legislature with information reported by school districts concerning incidents of serious student misconduct grouped into the following four major reporting categories: violence, vandalism, weapons, and substance abuse. An analysis of trends yields indications of progress and of ongoing concern, and…

International Laser Ranging Services (ILRS) 2001 Annual Report

NASA Technical Reports Server (NTRS)

Pearlman, Michael (Editor); Torrence, Mark (Editor); Noll, Carey (Editor)

2002-01-01

This 2001 Annual Report of the International Laser Ranging Services (ILRS) is comprised of individual contributions from ILRS components within the international geodetic community. This report documents the work of the ILRS components for the year 2001. The report documents changes and progress of the ILRS. This document is also available on the ILRS Web site at http://ilrs.gsfc.nasa.gov/reports/ilrs_reports/ilrsar_2001.html.

The 60th ASCD Annual Conference and Exhibit Show 2005, 2-4 April 2005: "Voices of Education--Unleashing the Power, Passion and Promise"

ERIC Educational Resources Information Center

Roberts, Brian

2005-01-01

Purpose: Aims to report on the 60th ASCD Annual Conference and Exhibit Show 2005, held in Orlando Florida, 2-4 April 2005 by the Association for Supervision and Curriculum Development. Design/methodology/approach: Discusses the presentations such as the obesity epidemic in children, educational progress in schools, creating capacity for learning,…

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update 2014

ERIC Educational Resources Information Center

Balfanz, Robert; Bridgeland, John M.; Fox, Joanna Hornig; DePaoli, Jennifer L.; Ingram, Erin S.; Maushard, Mary

2014-01-01

This fifth annual update on America's high school dropout crisis shows that, for the first time in history, the nation has crossed the 80 percent high school graduation rate threshold and remains on pace, for the second year in a row, to meet the goal of a 90 percent high school graduation rate by the Class of 2020. This report highlights key…

Biotic and abiotic processes controlling water chemistry during snowmelt at rabbit ears pass, Rocky Mountains, Colorado, U.S.A.

USGS Publications Warehouse

Peters, N.E.; Leavesley, G.H.

1995-01-01

The chemical composition of snowmelt, groundwater, and streamwater was monitored during the spring of 1991 and 1992 in a 200-ha subalpine catchment on the western flank of the Rocky Mountains near Steamboat Springs, Colorado. Most of the snowmelt occurred during a one-month period annually that began in mid-May 1991 and mid-April 1992. The average water quality characteristics of individual sampling sites (meltwater, streamwater, and groundwater) were similar in 1991 and 1992. The major ions in meltwater were differentially eluted from the snowpack, and meltwater was dominated by Ca2+, SO4/2-, and NO3/-. Groundwater and streamwater were dominated by weathering products, including Ca2+, HCO3/- (measured as alkalinity), and SiO2, and their concentrations decreased as snowmelt progressed. One well had extremely high NO3/- concentrations, which were balanced by Ca2+ concentrations. For this well, hydrogen ion was hypothesized to be generated from nitrification in overlying soils, and subsequently exchanged with other cations, particularly Ca2+. Solute concentrations in streamwater also decreased as snowmelt progressed. Variations in groundwater levels and solute concentrations indicate thai most of the meltwater traveled through the surficial materials. A mass balance for 1992 indicated that the watershed retained H+, NH4/+, NO3/-, SO4/2- and Cl- and was the primary source of base cations and other weathering products. Proportionally more SO4/2- was deposited with the unusually high summer rainfall in 1992 compared to that released from snowmelt, whereas NO3/- was higher in snowmelt and Cl- was the same. The sum of snowmelt and rainfall could account for greater than 90% of the H+ and NH4/+ retained by the watershed and greater than 50% of the NO3/-.The chemical composition of snowmelt, groundwater, and streamwater was monitored during the spring of 1991 and 1992 in a 200-ha subalpine catchment on the western flank of the Rocky Mountains near Steamboat Springs, Colorado. The major ions in meltwater were differentially eluted from the snowpack, and meltwater was dominated by Ca2+, SO42-, and NO3-. Groundwater and streamwater were dominated by weathering products and their concentrations decreased as snowmelt progressed. Solute concentrations in streamwater also decreased as snowmelt progressed. A mass balance for 1992 showed that the watershed retained H+, NH4+, NO3-, SO42- and Cl- and was the primary source of base cations and other weathering products.

Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI.

PubMed

Wang, S; Martinez-Lage, M; Sakai, Y; Chawla, S; Kim, S G; Alonso-Basanta, M; Lustig, R A; Brem, S; Mohan, S; Wolf, R L; Desai, A; Poptani, H

2016-01-01

Early assessment of treatment response is critical in patients with glioblastomas. A combination of DTI and DSC perfusion imaging parameters was evaluated to distinguish glioblastomas with true progression from mixed response and pseudoprogression. Forty-one patients with glioblastomas exhibiting enhancing lesions within 6 months after completion of chemoradiation therapy were retrospectively studied. All patients underwent surgery after MR imaging and were histologically classified as having true progression (>75% tumor), mixed response (25%-75% tumor), or pseudoprogression (<25% tumor). Mean diffusivity, fractional anisotropy, linear anisotropy coefficient, planar anisotropy coefficient, spheric anisotropy coefficient, and maximum relative cerebral blood volume values were measured from the enhancing tissue. A multivariate logistic regression analysis was used to determine the best model for classification of true progression from mixed response or pseudoprogression. Significantly elevated maximum relative cerebral blood volume, fractional anisotropy, linear anisotropy coefficient, and planar anisotropy coefficient and decreased spheric anisotropy coefficient were observed in true progression compared with pseudoprogression (P < .05). There were also significant differences in maximum relative cerebral blood volume, fractional anisotropy, planar anisotropy coefficient, and spheric anisotropy coefficient measurements between mixed response and true progression groups. The best model to distinguish true progression from non-true progression (pseudoprogression and mixed) consisted of fractional anisotropy, linear anisotropy coefficient, and maximum relative cerebral blood volume, resulting in an area under the curve of 0.905. This model also differentiated true progression from mixed response with an area under the curve of 0.901. A combination of fractional anisotropy and maximum relative cerebral blood volume differentiated pseudoprogression from nonpseudoprogression (true progression and mixed) with an area under the curve of 0.807. DTI and DSC perfusion imaging can improve accuracy in assessing treatment response and may aid in individualized treatment of patients with glioblastomas. © 2016 by American Journal of Neuroradiology.

Developing Precision Immunotherapies - Annual Plan

Cancer.gov

Despite remarkable progress, cancer immunotherapies can be toxic to some patients. Learn how NCI-funded research will extend the benefits of immunotherapy to more patients through biomarker research and collaboration.

Evidence for heterogeneity of astrocyte de-differentiation in vitro: astrocytes transform into intermediate precursor cells following induction of ACM from scratch-insulted astrocytes.

PubMed

Yang, Hao; Qian, Xin-Hong; Cong, Rui; Li, Jing-wen; Yao, Qin; Jiao, Xi-Ying; Ju, Gong; You, Si-Wei

2010-04-01

Our previous study definitely demonstrated that the mature astrocytes could undergo a de-differentiation process and further transform into pluripotential neural stem cells (NSCs), which might well arise from the effect of diffusible factors released from scratch-insulted astrocytes. However, these neurospheres passaged from one neurosphere-derived from de-differentiated astrocytes possessed a completely distinct characteristic in the differentiation behavior, namely heterogeneity of differentiation. The heterogeneity in cell differentiation has become a crucial but elusive issue. In this study, we show that purified astrocytes could de-differentiate into intermediate precursor cells (IPCs) with addition of scratch-insulted astrocyte-conditioned medium (ACM) to the culture, which can express NG2 and A2B5, the IPCs markers. Apart from the number of NG2(+) and A2B5(+) cells, the percentage of proliferative cells as labeled with BrdU progressively increased with prolonged culture period ranging from 1 to 10 days. Meanwhile, the protein level of A2B5 in cells also increased significantly. These results revealed that not all astrocytes could de-differentiate fully into NSCs directly when induced by ACM, rather they generated intermediate or more restricted precursor cells that might undergo progressive de-differentiation to generate NSCs.

Understanding Statistics - Cancer Statistics

Cancer.gov

Annual reports of U.S. cancer statistics including new cases, deaths, trends, survival, prevalence, lifetime risk, and progress toward Healthy People targets, plus statistical summaries for a number of common cancer types.

Annual Research Briefs, 1992

NASA Technical Reports Server (NTRS)

Spinks, Debra (Compiler)

1993-01-01

This report contains the 1992 annual progress reports of the Research Fellows and students of the Center for Turbulence Research. Considerable effort was focused on the large eddy simulation technique for computing turbulent flows. This increased activity has been inspired by the recent predictive successes of the dynamic subgrid scale modeling procedure which was introduced during the 1990 Summer Program. Several Research Fellows and students are presently engaged in both the development of subgrid scale models and their applications to complex flows. The first group of papers in this report contain the findings of these studies. They are followed by reports grouped in the general areas of modeling, turbulence physics, and turbulent reacting flows. The last contribution in this report outlines the progress made on the development of the CTR post-processing facility.

Moses Lake Fishery Restoration Project; Factors Affecting the Recreational Fishery in Moses Lake Washington, Annual Report 2002-2003.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgess, Dave

2003-11-01

This annual report is a precursor to the final technical report we will be writing the next contract period. Consequently, this report, covering the period between September 27, 2002, and September 26, 2003, represents a progress report towards the final technical report we anticipate completing by September 26, 2004. Sample analysis and field work have progressed well and we anticipate no further delays. There are 4 objectives: (1) To quantify secondary production Moses Lake; (2) To quantify the influence of predation on target fishes in Moses Lake; (3) To quantify mortality of selected fished in Moses Lake; and (4) Tomore » assess effects of habitat changes from shoreline development and carp on the fish community in Moses Lake.« less

LLE 2010 Annual Report October 2009 - September 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2011-01-01

The fiscal year ending September 2010 (FY10) concluded the third year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year including work on the National Ignition Campaign (NIC). It also reports on LLE's progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the NIC and high-energy density (HED) campaigns, the National Laser Users Facility (NLUF), and for other external users; andmore » programs focusing on the education of high school, undergraduate, and graduate students during the year.« less

Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64).

PubMed

Adler, Amanda I; Stevens, Richard J; Manley, Sue E; Bilous, Rudy W; Cull, Carole A; Holman, Rury R

2003-01-01

The progression of nephropathy from diagnosis of type 2 diabetes has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death. Using observed and modeled data from 5097 subjects in the UK Prospective Diabetes Study, we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of death from all-causes or cardiovascular disease. From diagnosis of diabetes, progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma creatinine (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of diabetes, the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma creatinine or RRT was 0.8%. Patients with elevated plasma creatinine or RRT had an annual death rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of cardiovascular death with increasing nephropathy (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no nephropathy, 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma creatinine or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop renal failure. The proportion of patients with type 2 diabetes who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer patients develop macroalbuminuria, but in those who do, the death rate exceeds the rate of progression to worse nephropathy.

Career Progress of Merit Scholars.

ERIC Educational Resources Information Center

Watley, Donivan J.

National Merit Scholars, chosen in 1956 and 1957, were studied to assess career progress made by highly gifted students 7 to 8 years after they had entered college and to identify factors that possibly contributed to the differential progress observed. Before entering college, each of the 368 subjects was asked what level of education he intended…

Crossing the invisible line: De-differentiation of wake, sleep and dreaming may engender both creative insight and psychopathology.

PubMed

Llewellyn, Sue

2016-11-01

Writing about dreaming, the poet Raymond Carver said "I feel as if I've crossed some kind of invisible line". In creative people, the "line" between wake, dreaming and psychopathology may be porous, engendering a de-differentiated, super-critical, hybrid state. Evidence exists for a relationship between creativity and psychopathology but its nature has been elusive. De-differentiation between wake, sleep and dreaming may be the common substrate, as dream-like cognition pervades wake and wake-like neurophysiology suffuses sleep. Chaos theory posits brain states as inherently labile, transient and dynamically unstable. Over and above transient dissociations, an enduring and, sometimes, progressive, de-differentiation may be possible. Evidence indicates that sleep and dreaming facilitate creative insight. In consequence, a mild to moderate form of de-differentiation may enhance creativity but if wake-like neurobiology permeates sleep this may disrupt sleep-dependent memory processing and emotional regulation. If de-differentiation is progressive and enduring, various forms of psychopathology may result. Copyright © 2016 Elsevier Inc. All rights reserved.

Building a Grad Nation: Progress and Challenge in Raising High School Graduation Rates. Annual Update 2016

ERIC Educational Resources Information Center

DePaoli, Jennifer L.; Balfanz, Robert; Bridgeland, John

2016-01-01

The nation has achieved an 82.3 percent high school graduation rate--a record high. Graduation rates rose for all student subgroups, and the number of low-graduation-rate high schools and students enrolled in them dropped again, indicating that progress has had far-reaching benefits for all students. This report is the first to analyze 2014…

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update, 2010-2011

ERIC Educational Resources Information Center

Balfanz, Robert; Bridgeland, John M.; Fox, Joanna Hornig; Moore, Laura A.

2011-01-01

America continues to make progress in meeting its high school dropout challenge. Leaders in education, government, nonprofits and business have awakened to the individual, social and economic costs of the dropout crisis and are working together to solve it. This year, all states, districts, and schools are required by law to calculate high school…

Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1984. Volume 1,

DTIC Science & Technology

1984-10-01

on a low dosage of medication . Technical Approach: None. Progress: The placebo has not been received from the company. Since the drug company...determine the effect of high dose Ar-C intensification therapy on the -. incidence of CNS relapse. - Technical Approach: All patients with a new...Enrolled to Date: 7 Date of Periodic Review Results Objective(s): To determine the incidence of

USAARL Annual Progress Report Fiscal Year 2012

DTIC Science & Technology

2013-04-01

analyzed. A technical report is currently in progress. A research project entitled “Clinical Assessment of the Noise Immune Stethoscope ” evaluated the...noise immune stethoscope (NIS), a dual mode electronic and Doppler device, at Madigan Army Medical Center. Insight from the evaluations, data...Immune Stethoscope aboard a U.S. Navy Carrier. (Report No. 2012-02). Fort Rucker, AL: U.S. Army Aeromedical Research Laboratory. Gordon, E., & Reeves

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update, 2012

ERIC Educational Resources Information Center

Balfanz, Robert; Bridgeland, John M.; Bruce, Mary; Fox, Joanna Hornig

2012-01-01

In 2010, the authors shared a Civic Marshall Plan to create a Grad Nation. Through that first report and subsequent update, they saw hopeful signs of progress in boosting high school graduation rates in communities across the country. This 2012 report shows that high school graduation rates continue to improve nationally and across many states and…

Implementing the Common Core State Standards: Year Three Progress Report from the Great City Schools. Results from 2013-14 School Year

ERIC Educational Resources Information Center

Palacios, Moses; Casserly, Michael; Corcoran, Amanda; Hart, Ray; Simon, Candace; Uzzell, Renata

2014-01-01

Three years ago, the "Council of the Great City Schools" embarked on a multi-year initiative to help its member school districts implement the Common Core State Standards (CCSS). Part of this initiative involves annual surveys of progress urban public school districts were making in implementing the CCSS. With the support of the Bill…

Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA.

PubMed

Gröttrup, Bernd; May, Caroline; Meyer, Helmut E; Grinberg, Lea T; Park, Young Mok

2013-01-01

The HUPO Brain Proteome Project (HUPO BPP) held its 18(th) workshop in Boston, USA, September 12(th) 2012 during the HUPO 11th Annual Word Congress. The focus was on the progress on the Human Brain Proteome Atlas as well as ideas, strategies and methodological aspects. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Gas-Cooled Reactor Programs annual progress report for period ending December 31, 1973. [HTGR fuel reprocessing, fuel fabrication, fuel irradiation, core materials, and fission product distribution; GCFR fuel irradiation and steam generator modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasten, P.R.; Coobs, J.H.; Lotts, A.L.

1976-04-01

Progress is summarized in studies relating to HTGR fuel reprocessing, refabrication, and recycle; HTGR fuel materials development and performance testing; HTGR PCRV development; HTGR materials investigations; HTGR fuel chemistry; HTGR safety studies; and GCFR irradiation experiments and steam generator modeling.

Inhalation Toxicology Research Institute Annual Report, 1992-1993

DTIC Science & Technology

1993-11-01

for Mineral and Energy Technology ( CANMET ). The ITRI team participated in all phases of the intercomparison studies. The methods, procedures, and...differential cloning, and differential hybridization techniques. However, with recent advances in polymerase chain reaction (PCR) technology , an...viii I. AEROSOL TECHNOLOGY AND CHARACTERIZATION OF AIRBORNE MATERIALS Measurement of Thoron and Thoron/Radon Mixtures Y. S. Cheng and H. C. Yeh Use of a

A Shared Commitment to the Cancer Moonshot

Cancer.gov

At the AACR annual meeting, Vice President Biden spoke about the National Cancer Moonshot Initiative and the critical role the entire research community will play in accelerating progress against cancer.

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

DOE PAGES

Ugarte, Fernando; Sousae, Rebekah; Cinquin, Bertrand; ...

2015-10-17

Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem cell function. Using nuclease sensitivity assays, we found a progressive decrease in chromatin digestion among pluripotent embryonic stem cells (ESCs), multipotent hematopoietic stem cells (HSCs), and mature hematopoietic cells. Quantitative high-resolution microscopy revealed that ESCs contain significantly more euchromatin than HSCs, with a further reduction in mature cells. Increasedmore » cellular maturation also led to heterochromatin localization to the nuclear periphery. Functionally, prevention of heterochromatin formation by inhibition of the histone methyltransferase G9A resulted in delayed HSC differentiation. Lastly, our results demonstrate global chromatin rearrangements during stem cell differentiation and that heterochromatin formation by H3K9 methylation regulates HSC differentiation.« less

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ugarte, Fernando; Sousae, Rebekah; Cinquin, Bertrand

Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem cell function. Using nuclease sensitivity assays, we found a progressive decrease in chromatin digestion among pluripotent embryonic stem cells (ESCs), multipotent hematopoietic stem cells (HSCs), and mature hematopoietic cells. Quantitative high-resolution microscopy revealed that ESCs contain significantly more euchromatin than HSCs, with a further reduction in mature cells. Increasedmore » cellular maturation also led to heterochromatin localization to the nuclear periphery. Functionally, prevention of heterochromatin formation by inhibition of the histone methyltransferase G9A resulted in delayed HSC differentiation. Lastly, our results demonstrate global chromatin rearrangements during stem cell differentiation and that heterochromatin formation by H3K9 methylation regulates HSC differentiation.« less

Permeability estimates in histopathology-proved treatment-induced necrosis using perfusion CT: can these add to other perfusion parameters in differentiating from recurrent/progressive tumors?

PubMed

Jain, R; Narang, J; Schultz, L; Scarpace, L; Saksena, S; Brown, S; Rock, J P; Rosenblum, M; Gutierrez, J; Mikkelsen, T

2011-04-01

Differentiating treatment effects from RPT is a common yet challenging task in a busy neuro-oncologic practice. PS probably represents a different aspect of angiogenesis and vasculature and can provide additional physiologic information about recurrent/progressive enhancing lesions. The purpose of the study was to use PS measured by using PCT to differentiate TIN from RPT in patients with previously irradiated brain tumor who presented with a recurrent/progressive enhancing lesion. Seventy-two patients underwent PCT for assessment of a recurrent/progressive enhancing lesion from January 2006 to November 2009. Thirty-eight patients who underwent surgery and histopathologic diagnosis were included in this analysis. Perfusion parameters such as PS, CBV, CBF, and MTT were obtained from the enhancing lesion as well as from the NAWM. Of 38 patients, 11 were diagnosed with pure TIN and 27 had RPT. Patients with TIN showed significantly lower mean PS values than those with RPT (1.8 ± 0.8 versus 3.6 ± 1.6 mL/100 g/min; P value=.001). The TIN group also showed lower rCBV (1.2 ± 0.3 versus 2.1 ± 0.7; P value<.001), lower rCBF (1.2 ± 0.5 versus 2.6 ± 1.7; P value=.004), and higher rMTT (1.4 ± 0.4 versus 1.0 ± 0.4; P value=.018) compared with the RPT group. PCT and particularly PS can be used in patients with previously treated brain tumors to differentiate TIN from RPT. PS estimates can help increase the accuracy of PCT in differentiating these 2 entities.

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update 2015

ERIC Educational Resources Information Center

DePaoli, Jennifer L.; Fox, Joanna Hornig; Ingram, Erin S.; Maushard, Mary; Bridgeland, John M.; Balfanz, Robert

2015-01-01

In 2013, the national high school graduation rate hit a record high of 81.4 percent, and for the third year in a row, the nation remained on pace to meet the 90 percent goal by the Class of 2020. This sixth annual update on America's high school dropout challenge shows that these gains have been made possible by raising graduation rates for…

Building a Family Systems Model to Promote Adherence to PTSD Treatment

DTIC Science & Technology

2015-10-01

stress disorder ( PTSD ) result in clinically significant symptom relief for many patients and are recommended as first-line treatments by the VA/DOD...findings at the annual meeting of the International Society of Traumatic Stress Studies (see citations below) and at an In Progress Review on 9/11...presentation at the 30th annual meeting of the International Society of Traumatic Stress Studies, Miami, Florida. ABSTRACT: We examined the role of family

U.S. Army Aeromedical Research Laboratory Annual Progress Report Fiscal Year 2010

DTIC Science & Technology

2011-03-01

S. (2010). Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 ( TRPV1 ...induced by TRPV1 in human corneal epithelial cells. Proceedings of the Association for Research in Vision and Ophthalmology Annual Meeting, 5899/A94...presented “Novel TRPV1 -linked cell signaling pathways mediating inflammatory responses and wound healing in human corneal epithelial cells” at the Fouth

Department of Clinical Investigation Annual Research Progress Report.

DTIC Science & Technology

1995-09-30

20th Annual Uniformed Services Fractures ?. Academy of Family Physicians, San Diego, USA, April 95. DeWeber K Factors Associated With Physicians’s USAFP...Resonance Mammography (MRM): A Promising 313 #94/159 Application for Fat Suppression by Phase Unwrapping in the 3-Point-Dixon Method Makuch RS 0...Isotonic Saline, Purified Water, and 378 #95/082 Dilute Hypochlorite Solution on the Rates of Infection and Tissue Response in Open Fractures of a

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update, 2013

ERIC Educational Resources Information Center

Balfanz, Robert; Bridgeland, John M.; Bruce, Mary; Fox, Joanna Hornig

2013-01-01

This fourth annual update on America's high school dropout crisis shows that for the first time the nation is on track to meet the goal of a 90 percent high school graduation rate by the Class of 2020--if the pace of improvement from 2006 to 2010 is sustained over the next 10 years. The greatest gains have occurred for the students of color and…

Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy.

PubMed

Ostrovidov, Serge; Shi, Xuetao; Sadeghian, Ramin Banan; Salehi, Sahar; Fujie, Toshinori; Bae, Hojae; Ramalingam, Murugan; Khademhosseini, Ali

2015-12-01

Skeletal muscle tissue engineering is one of the important ways for regenerating functionally defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a progressive disease due to mutations of the dystrophin gene leading to progressive myofiber degeneration with severe symptoms. Although current therapies in muscular dystrophy are still very challenging, important progress has been made in materials science and in cellular technologies with the use of stem cells. It is therefore useful to review these advances and the results obtained in a clinical point of view. This article focuses on the differentiation of stem cells into myoblasts, and their application in muscular dystrophy. After an overview of the different stem cells that can be induced to differentiate into the myogenic lineage, we introduce scaffolding materials used for muscular tissue engineering. We then described some widely used methods to differentiate different types of stem cell into myoblasts. We highlight recent insights obtained in therapies for muscular dystrophy. Finally, we conclude with a discussion on stem cell technology. We discussed in parallel the benefits brought by the evolution of the materials and by the expansion of cell sources which can differentiate into myoblasts. We also discussed on future challenges for clinical applications and how to accelerate the translation from the research to the clinic in the frame of DMD.

14 CFR 91.875 - Annual progress reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Operating Noise Limits § 91... report, that specific planning data be considered proprietary. (e) If an operator's actions during any...

14 CFR 91.875 - Annual progress reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Operating Noise Limits § 91... report, that specific planning data be considered proprietary. (e) If an operator's actions during any...

14 CFR 91.875 - Annual progress reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Operating Noise Limits § 91... report, that specific planning data be considered proprietary. (e) If an operator's actions during any...

14 CFR 91.875 - Annual progress reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Operating Noise Limits § 91... report, that specific planning data be considered proprietary. (e) If an operator's actions during any...

14 CFR 91.875 - Annual progress reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Operating Noise Limits § 91... report, that specific planning data be considered proprietary. (e) If an operator's actions during any...

78 FR 50075 - Statewide Communication Interoperability Plan Template and Annual Progress Report

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... of Cybersecurity and Communications (CS&C), Office of Emergency Communications (OEC), will submit the... Directorate, Office of Cybersecurity and Communications, Office of Emergency Communications. Title: Statewide...

Investigation for the differentiation process of mouse ES cells by Raman spectroscopy

NASA Astrophysics Data System (ADS)

Yamaguchi, Yoshinori; El-Hagrasy, Maha A.; Shimizu, Eiichi; Saito, Masato; Tamiya, Eiichi

2012-03-01

The arrangement of differentiated pluripotent embryonic stem cells into three-dimensional aggregates, which are known as embryonic bodies, is a main step for progressing the embryonic stem cells differentiation. In this work, embryonic stem cells that were directly produced from the hanging drop step as a three-dimensional structure with no further twodimensional differentiation were diagnosed with Raman spectroscopy as a non-invasive and label-free technique. Raman spectroscopy was employed to discriminate between mouse embryonic bodies of different degrees of maturation. EBs were prepared applying the hanging drop method. The Raman scattering measurements were obtained in vitro with a Nanophoton RAMAN-11 micro-spectrometer (Japan: URL: www.nanophoton.jp equipped with an Olympus XLUM Plan FLN 20X/NA= 1.0 objective lens. Spectral data were smoothed, baseline corrected and normalized to the a welldefined intense 1003 cm-1 band (phenylalanine) which is insensitive to changes in conformation or environment. The differentiation process of embryonic stem cells is initiated by the removal of LIF from culture medium. 1, 7 and 17-dayold embryonic stem cells were collected and investigated by Raman spectroscopy. The main differences involve bands which decreased with maturation such as: 784 cm-1 (U, T, C ring br DNA/RNA, O-P-O str); 1177 cm-1 (cytosine, guanine) and 1578 cm-1 (G, A). It was found that with the progress of differentiation the protein content was amplified. The increase of protein to nucleic acid ratio was also previously observed with the progress of the differentiation process. Raman spectroscopy has the potential to distinguish between the Raman signatures of live embryonic stem cells with different degrees of maturation.

Structure and function of Frankia vesicles in denitrogen fixation by actinorhizal plants: Annual technical progress report for period January 1, 1987-November 15, 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torrey, J.G.

1987-11-20

Frankia is a filamentous soil bacterium of the Actinomycetales that is capable of fixation of atmospheric dinitrogen both in the free-living state and within root modules of a number of woody dicotyledonous plants in a symbiotic process. The bacterium is of special interest because of its genetic capacity to differentiate terminal swellings of the hyphal filaments called vesicles. Vesicles form in the free-living organism when deprived of combined nitrogen substrates under aerobic conditions. A multilaminate envelope surrounds the vesicle providing a barrier to direct exposure of the oxygen-labile nitrogenase enzyme that forms within the vesicle. In root nodules, vesicles maymore » or may not form, depending upon the structural configuration of the host plant cells, the ambient oxygen concentration surrounding the root nodule and the expression of host-microbial interactions under the control of the two genomes. Under varying stresses of nutrient availability and the changing gaseous environment, remarkable adaptations may occur in either or both partners of the symbiosis to optimize dinitrogen fixation. 9 refs.« less

Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

PubMed Central

Fukuyama, Satoshi; Katsura, Hiroaki; Zhao, Dongming; Ozawa, Makoto; Ando, Tomomi; Shoemaker, Jason E.; Ishikawa, Izumi; Yamada, Shinya; Neumann, Gabriele; Watanabe, Shinji; Kitano, Hiroaki; Kawaoka, Yoshihiro

2015-01-01

Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours (‘Color-flu’ viruses) to facilitate the study of viral infection in in vivo models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allows their detection by different types of microscopy and by flow cytometry. We use this system to analyse the progression of viral spread in mouse lungs, for live imaging of virus-infected cells, and for differential gene expression studies in virus antigen-positive and virus antigen-negative live cells in the lungs of Color-flu-infected mice. Collectively, Color-flu viruses are powerful tools to analyse virus infections at the cellular level in vivo to better understand influenza pathogenesis. PMID:25807527

Solving Differential Equations in R

EPA Science Inventory

Although R is still predominantly applied for statistical analysis and graphical representation, it is rapidly becoming more suitable for mathematical computing. One of the fields where considerable progress has been made recently is the solution of differential equations. Here w...

Model-Based Phenotypic Signatures Governing the Dynamics of the Stem and Semi-differentiated Cell Populations in Dysplastic Colonic Crypts.

PubMed

Nikolov, Svetoslav; Santos, Guido; Wolkenhauer, Olaf; Vera, Julio

2018-02-01

Mathematical modeling of cell differentiated in colonic crypts can contribute to a better understanding of basic mechanisms underlying colonic tissue organization, but also its deregulation during carcinogenesis and tumor progression. Here, we combined bifurcation analysis to assess the effect that time delay has in the complex interplay of stem cells and semi-differentiated cells at the niche of colonic crypts, and systematic model perturbation and simulation to find model-based phenotypes linked to cancer progression. The models suggest that stem cell and semi-differentiated cell population dynamics in colonic crypts can display chaotic behavior. In addition, we found that clinical profiling of colorectal cancer correlates with the in silico phenotypes proposed by the mathematical model. Further, potential therapeutic targets for chemotherapy resistant phenotypes are proposed, which in any case will require experimental validation.

Retinoic Acid Therapy Resistance Progresses from Unilineage to Bilineage in HL-60 Leukemic Blasts

PubMed Central

Jensen, Holly A.; Bunaciu, Rodica P.; Ibabao, Christopher N.; Myers, Rebecca; Varner, Jeffrey D.; Yen, Andrew

2014-01-01

Emergent resistance can be progressive and driven by global signaling aberrations. All-trans retinoic acid (RA) is the standard therapeutic agent for acute promyelocytic leukemia, but 10–20% of patients are not responsive, and initially responsive patients relapse and develop retinoic acid resistance. The patient-derived, lineage-bipotent acute myeloblastic leukemia (FAB M2) HL-60 cell line is a potent tool for characterizing differentiation-induction therapy responsiveness and resistance in t(15;17)-negative cells. Wild-type (WT) HL-60 cells undergo RA-induced granulocytic differentiation, or monocytic differentiation in response to 1,25-dihydroxyvitamin D3 (D3). Two sequentially emergent RA-resistant HL-60 cell lines, R38+ and R38-, distinguishable by RA-inducible CD38 expression, do not arrest in G1/G0 and fail to upregulate CD11b and the myeloid-associated signaling factors Vav1, c-Cbl, Lyn, Fgr, and c-Raf after RA treatment. Here, we show that the R38+ and R38- HL-60 cell lines display a progressive reduced response to D3-induced differentiation therapy. Exploiting the biphasic dynamic of induced HL-60 differentiation, we examined if resistance-related defects occurred during the first 24 h (the early or “precommitment” phase) or subsequently (the late or “lineage-commitment” phase). HL-60 were treated with RA or D3 for 24 h, washed and retreated with either the same, different, or no differentiation agent. Using flow cytometry, D3 was able to induce CD38, CD11b and CD14 expression, and G1/G0 arrest when present during the lineage-commitment stage in R38+ cells, and to a lesser degree in R38- cells. Clustering analysis of cytometry and quantified Western blot data indicated that WT, R38+ and R38- HL-60 cells exhibited decreasing correlation between phenotypic markers and signaling factor expression. Thus differentiation induction therapy resistance can develop in stages, with initial partial RA resistance and moderate vitamin D3 responsiveness (unilineage maturation block), followed by bilineage maturation block and progressive signaling defects, notably the reduced expression of Vav1, Fgr, and c-Raf. PMID:24922062

Solar Power Use Claims

EPA Pesticide Factsheets

The U.S. EPA's Green Power Partnership is a voluntary program designed to reduce the environmental impact of electricity generation by promoting renewable energy. EPA evaluates partnership metrics annually to determine progress toward programmatic goals.

Cosmic x ray physics

NASA Technical Reports Server (NTRS)

Mccammon, Dan; Cox, D. P.; Kraushaar, W. L.; Sanders, W. T.

1990-01-01

The annual progress report on Cosmic X Ray Physics is presented. Topics studied include: the soft x ray background, proportional counter and filter calibrations, the new sounding rocket payload: X Ray Calorimeter, and theoretical studies.

Seasonal response of feeding, differentiation, and growth in the eastern subterranean termite Reticulitermes flavipes (Kollar) in Wisconsin

Treesearch

Rachel Ann Arango; Frederick Green; Glenn R. Esenther

2007-01-01

In termites, differentiation plasticity in undifferentiated Reticulitermes progresses with growth stages from larvae to workers, which may then differentiate into soldiers, winged nymphs, or neotenics. Although studies have been done on seasonality of the termite life cycle, data appears to vary from location to location. Reticulitermes populations in Wisconsin appear...

Annual Progress Report on the Development of Waste Tank Leak Monitoring and Detection and Mitigation Activities in Support of M-45-08

DOE Office of Scientific and Technical Information (OSTI.GOV)

DEFIGH PRICE, C.

2000-09-25

Milestone M-45-09E of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement or TPA) [TPA 1996] requires submittal of an annual progress report on the development of waste tank leak detection, monitoring, and mitigation (LDMM) activities associated with the retrieval of waste from single-shell tanks (SSTs). This report details progress for fiscal year 2000, building on the current LDMM strategy and including discussion of technologies, applications, cost, schedule, and technical data. The report also includes discussion of demonstrations conducted and recommendations for additional testing. Tri-Party Agreement Milestones M-45-08A and M-45-08B required design and demonstration of LDMM systems for initialmore » retrieval of SST waste. These specific milestones have recently been deleted as part of the M-45-00A change package. Future LDMM development work has been incorporated into specific technology demonstration milestones and SST waste retrieval milestones in the M-45-03 and M-45-05 milestone series.« less

PCT Databank: A Tool for Planning, Implementation and Monitoring of Integrated Preventive Chemotherapy for Control of Neglected Tropical Diseases (NTD)

PubMed Central

Mikhailov, Alexei; Yajima, Aya; Mbabazi, PS; Gabrielli, Albis F.; Montresor, Antonio; Engels, Dirk

2017-01-01

The integration of vertical control programmes of neglected tropical diseases (NTDs) aims at containing operational cost, simplifies the application of the control measures and extends the intervention coverage. The Preventive Chemotherapy and Transmission Control (PCT) Databank was established by the World Health Organization to facilitate the sharing of data among the different partners involved in control activities and collects and compiles historical and current information on disease-specific epidemiological situation, the geographical overlapping of NTDs and the progress of control activities in all the NTD-endemic countries. The summary of country-specific epidemiological maps and the progress of control activities is available online as the online PCT Databank and Country Profiles. The annual progress of preventive chemotherapy (PC) interventions targeting at specific NTDs is also annually reported in the Weekly Epidemiological Record (WER). In this paper, we elucidated the methodology of data collection, compilation and mapping to establish the PCT Databank and presented the key features of the associated three online outputs, i.e. the online PCT Databank, the Country Profile and the WER. PMID:22357399

ANALYTICAL CHEMISTRY DIVISION ANNUAL PROGRESS REPORT FOR PERIOD ENDING DECEMBER 31, 1961

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1962-02-01

Research and development progress is reported on analytlcal instrumentation, dlssolver-solution analyses, special research problems, reactor projects analyses, x-ray and spectrochemical analyses, mass spectrometry, optical and electron microscopy, radiochemical analyses, nuclear analyses, inorganic preparations, organic preparations, ionic analyses, infrared spectral studies, anodization of sector coils for the Analog II Cyclotron, quality control, process analyses, and the Thermal Breeder Reactor Projects Analytical Chemistry Laboratory. (M.C.G.)

Analytical Chemistry Division annual progress report for period ending December 31, 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shultz, W.D.

1986-05-01

Progress reports are presented for the four major sections of the division: analytical spectroscopy, radioactive materials laboratories, inorganic chemistry, and organic chemistry. A brief discussion of the division's role in the Laboratory's Environmental Restoration and Facilities Upgrade is given. Information about quality assurance and safety programs is presented, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited.

ANNUAL REPORT, JULY 1, 1957

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1958-10-31

The progress and trends of research are presented along with a description of operational, service, end administrative activities. Some scientific and technical details are given on research programs in the physical sciences, life sciences, and engineering, however, more complete technical information is available in quarterly progress reports, BNL technical reports, and scientific and technical periodicals. A bibliography of these publications is appended. (For preceding period see BNL-426.) (D.E.B.)

Annual Progress Report FY-92. Volume 2

DTIC Science & Technology

1992-01-01

OBJECTIVE To measure the effect of methotrexate on interleukin-l ( IL - 1 ) induced ICAN-l expression in cultured human fibroblasts and adenocarcinoma cells...SUMMARY SHEET TITLE: Effect of IL - 1 on Glucocorticoid Inhibition of Wound Healing KEYWORDS: IL - 1 , wound healing PRINCIPAL INVESTIGATOR: Schoenfeld, Phil CPT...PROGRESS Cultured cells were incubated with IL -l to stimulate ICAM-l expression. In general, the cells responded well. ICAM- 1 was readily detectable

Closing the Achievement Gap for Economically Disadvantaged Students? Analyzing Change since No Child Left Behind Using State Assessments and the National Assessment of Educational Progress

ERIC Educational Resources Information Center

Blank, Rolf K.

2011-01-01

A critical state-level indicator of progress in public education is student achievement annual performance and change over time. The Council of Chief State School Officers (CCSSO) has been very active in tracking and reporting on student achievement results and using state assessment scores and other data to analyze achievement trends. A central…

University Research Initiative Program for Combat Readiness, Annual Report for the Period June 1, 1997 - June 30, 1998

DTIC Science & Technology

1998-05-01

polysaccharides ) can be interpreted by matching to these chemical markers. Differentiation of the aldohexose monosaccharides or determination of simple...experiments involving qualitative and quantitative analysis of monomeric carbohydrate content in bacterial polysaccharides by Py-GC/MS has been...residues in the group-specific polysaccharide of group B streptococci8 and differentiation of B. anthracis strains by a pyrolysis product from its

Academic status and progress of deaf and hard-of-hearing students in general education classrooms.

PubMed

Antia, Shirin D; Jones, Patricia B; Reed, Susanne; Kreimeyer, Kathryn H

2009-01-01

The study participants were 197 deaf or hard-of-hearing students with mild to profound hearing loss who attended general education classes for 2 or more hours per day. We obtained scores on standardized achievement tests of math, reading, and language/writing, and standardized teacher's ratings of academic competence annually, for 5 years, together with other demographic and communication data. Results on standardized achievement tests indicated that, over the 5-year period, 63%-79% of students scored in the average or above-average range in math, 48%-68% in reading, and 55%-76% in language/writing. The standardized test scores for the group were, on average, half an SD below hearing norms. Average student progress in each subject area was consistent with or better than that made by the norm group of hearing students, and 79%-81% of students made one or more year's progress annually. Teachers rated 69%-81% of students as average or above average in academic competence over the 5 years. The teacher's ratings also indicated that 89% of students made average or above-average progress. Students' expressive and receptive communication, classroom participation, communication mode, and parental participation in school were significantly, but moderately, related to academic outcomes.

Pesticide Reregistration Performance Measures and Goals 1997-2008

EPA Pesticide Factsheets

Find past annual reports that were submitted, as required by the Federal Insecticide Fungicide and Rodenticide Act (as amended by FQPA), describing the agency's progress in meeting goals for reregistration and tolerance assessment.

Solid State Division annual progress report for period ending December 31, 1975

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkinson, M.K.; Young, F.W. Jr.

1976-05-01

Research activities are reported in programs on theoretical solid state physics, physical properties of solids, radiation effects in metals, neutron scattering, research materials, and isotope research materials. (JRD)

Green Power Partnership Program Success Metrics

EPA Pesticide Factsheets

The U.S. EPA's Green Power Partnership is a voluntary program designed to reduce the environmental impact of electricity generation by promoting renewable energy. EPA evaluates partnership metrics annually to determine progress toward programmatic goals.

Meetings | Informatics Technology for Cancer Research (ITCR)

Cancer.gov

ITCR Annual Meetings Meetings with ITCR Principal Investigators (PIs) and program staff to discuss progress, facilitate collaborations and solicit feedback from program participants. Meeting agendas, notes and presentations are available through the links below.

7 CFR 3405.19 - Monitoring progress of funded projects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the first year of the project and annually thereafter during the life of the grant. Generally, the... agricultural sciences higher education system; and data on project personnel and beneficiaries. The Final...

Cosmic x ray physics

NASA Technical Reports Server (NTRS)

Mccammon, Dan; Cox, D. P.; Kraushaar, W. L.; Sanders, W. T.

1991-01-01

The annual progress report on Cosmic X Ray Physics for the period 1 Jan. to 31 Dec. 1990 is presented. Topics studied include: soft x ray background, new sounding rocket payload: x ray calorimeter, and theoretical studies.

Benchmarking of OEM Hybrid Electric Vehicles at NREL: Milestone Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelly, K. J.; Rajagopalan, A.

2001-10-26

A milestone report that describes the NREL's progress and activities related to the DOE FY2001 Annual Operating Plan milestone entitled ''Benchmark 2 new production or pre-production hybrids with ADVISOR.''

7 CFR 3405.19 - Monitoring progress of funded projects.

Code of Federal Regulations, 2011 CFR

2011-01-01

... thereafter during the life of the grant. Generally, the Annual Performance Reports should include a summary... director(s), the institution, and the food and agricultural sciences higher education system; and data on...

7 CFR 3405.19 - Monitoring progress of funded projects.

Code of Federal Regulations, 2014 CFR

2014-01-01

... thereafter during the life of the grant. Generally, the Annual Performance Reports should include a summary... director(s), the institution, and the food and agricultural sciences higher education system; and data on...

7 CFR 3405.19 - Monitoring progress of funded projects.

Code of Federal Regulations, 2013 CFR

2013-01-01

... thereafter during the life of the grant. Generally, the Annual Performance Reports should include a summary... director(s), the institution, and the food and agricultural sciences higher education system; and data on...

7 CFR 3405.19 - Monitoring progress of funded projects.

Code of Federal Regulations, 2012 CFR

2012-01-01

... thereafter during the life of the grant. Generally, the Annual Performance Reports should include a summary... director(s), the institution, and the food and agricultural sciences higher education system; and data on...

78 FR 18597 - Proposed Data Collections Submitted for Public Comment and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... collection techniques or other forms of information technology. Written comments should be received within 60... Annual Report that describes activities, progress toward objectives, and Success Stories which highlight...

Identification of the Spawning, Rearing, and Migratory Requirements of Fall Chinook Salmon in the Columbia River Basin, 1991 Annual Progress Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rondorf, Dennis W.; Miller, William H.

1993-07-01

This document is the 1991 annual progress report for selected studies of fall chinook salmon Oncorhynchus tshawytscha conducted by the US Fish and Wildlife Service. The decline in abundance of fall chinook salmon in the Snake River basin has become a growing concern. In April 1992, Snake River fall chinook salmon were listed as ``threatened`` under the Endangered Species Act. Effective recovery efforts for fall chinook salmon can not be developed until we increase our knowledge of the factors that are limiting the various life history stages. This study attempts to identify those physical and biological factors which influence spawningmore » of fall chinook salmon in the free-flowing Snake River and their rearing and seaward migration through Columbia River basin reservoirs.« less

Annual report to Congress. Department of Energy activities relating to the Defense Nuclear Facilities Safety Board, calendar year 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2001-03-01

This Annual Report to the Congress describes the Department of Energy's activities in response to formal recommendations and other interactions with the Defense Nuclear Facilities Safety Board. During 2000, the Department completed its implementation and proposed closure of one Board recommendation and completed all implementation plan milestones associated with two additional Board recommendations. Also in 2000, the Department formally accepted two new Board recommendations and developed implementation plans in response to those recommendations. The Department also made significant progress with a number of broad-based safety initiatives. These include initial implementation of integrated safety management at field sites and within headquartersmore » program offices, issuance of a nuclear safety rule, and continued progress on stabilizing excess nuclear materials to achieve significant risk reduction.« less

Annual Collection and Storage of Solar Energy for the Heating of Buildings, Report No. 3. Semi-Annual Progress Report, August 1977 - January 1978.

ERIC Educational Resources Information Center

Beard, J. Taylor; And Others

This report is part of a series from the Department of Energy on the use of solar energy in heating buildings. Described here is a new system for year around collection and storage of solar energy. This system has been operated at the University of Virginia for over a year. Composed of an underground hot water storage system and solar collection,…

Design and application of electromechanical actuators for deep space missions

NASA Technical Reports Server (NTRS)

Haskew, Tim A.; Wander, John

1993-01-01

The annual report Design and Application of Electromechanical Actuators for Deep Space Missions is presented. The reporting period is 16 Aug. 1992 to 15 Aug. 1993. However, the primary focus will be work performed since submission of our semi-annual progress report in Feb. 1993. Substantial progress was made. We currently feel confident in providing guidelines for motor and control strategy selection in electromechanical actuators to be used in thrust vector control (TVC) applications. A small portion was presented in the semi-annual report. At this point, we have implemented highly detailed simulations of various motor/drive systems. The primary motor candidates were the brushless dc machine, permanent magnet synchronous machine, and the induction machine. The primary control implementations were pulse width modulation and hysteresis current control. Each of the two control strategies were applied to each of the three motor choices. With either pulse width modulation or hysteresis current control, the induction machine was always vector controlled. A standard test position command sequence for system performance evaluation is defined. Currently, we are gathering all of the necessary data for formal presentation of the results. Briefly stated for TVC application, we feel that the brushless dc machine operating under PWM current control is the best option. Substantial details on the topic, with supporting simulation results, will be provided later, in the form of a technical paper prepared for submission and also in the next progress report with more detail than allowed for paper publication.

Ecological requirements for pallid sturgeon reproduction and recruitment in the Missouri River: annual report 2011

USGS Publications Warehouse

DeLonay, Aaron J.; Jacobson, Robert B.; Chojnacki, Kimberly A.; Annis, Mandy L.; Braaten, P. J.; Elliott, Caroline M.; Fuller, D. B.; Haas, Justin D.; Haddix, Tyler M.; Ladd, Hallie L.A.; McElroy, Brandon J.; Mestl, Gerald E.; Papoulias, Diana M.; Rhoten, Jason C.; Wildhaber, Mark L.

2014-01-01

The Comprehensive Sturgeon Research Project is a multiyear, multiagency collaborative research framework developed to provide information to support pallid sturgeon recovery and Missouri River management decisions. The project strategy integrates field and laboratory studies of sturgeon reproductive ecology, early life history, habitat requirements, and physiology. The project scope of work is developed annually with cooperating research partners and in collaboration with the U.S. Army Corps of Engineers, Missouri River Recovery—Integrated Science Program. The research consists of several interdependent and complementary tasks that engage multiple disciplines. The research tasks in the 2011 scope of work emphasized understanding of reproductive migrations and spawning of adult sturgeon, and hatch and drift of larvae. These tasks were addressed in three hydrologically and geomorphologically distinct parts of the Missouri River Basin: the Lower Missouri River downstream from Gavins Point Dam, the Upper Missouri River downstream from Fort Peck Dam and including downstream reaches of the Milk River, and the Lower Yellowstone River. The research is designed to inform management decisions related to channel re-engineering, flow modification, and pallid sturgeon population augmentation on the Missouri River, and throughout the range of the species. Research and progress made through this project are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by the Comprehensive Sturgeon Research Project during 2011.

Ecological requirements for pallid sturgeon reproduction and recruitment in the Missouri River—Annual report 2014

USGS Publications Warehouse

Delonay, Aaron J.; Chojnacki, Kimberly A.; Jacobson, Robert B.; Braaten, Patrick J.; Buhl, Kevin J.; Elliott, Caroline M.; Erwin, Susannah O.; Faulkner, Jacob D.A.; Candrl, James S.; Fuller, David B.; Backes, Kenneth M.; Haddix, Tyler M.; Rugg, Matthew L.; Wesolek, Christopher J.; Eder, Brandon L.; Mestl, Gerald E.

2016-03-16

The Comprehensive Sturgeon Research Project is a multiyear, multiagency collaborative research framework developed to provide information to support pallid sturgeon recovery and Missouri River management decisions. The project strategy integrates field and laboratory studies of sturgeon reproductive ecology, early life history, habitat requirements, and physiology. The project scope of work is developed annually with collaborating research partners and in cooperation with the U.S. Army Corps of Engineers, Missouri River Recovery Program–Integrated Science Program. The project research consists of several interdependent and complementary tasks that involve multiple disciplines.The project research tasks in the 2014 scope of work emphasized understanding of reproductive migrations and spawning of adult pallid sturgeon and hatch and drift of larvae. These tasks were addressed in three hydrologically and geomorphologically distinct parts of the Missouri River Basin: the Lower Missouri River downstream from Gavins Point Dam, the Upper Missouri River downstream from Fort Peck Dam and downstream reaches of the Milk River, and the Lower Yellowstone River. The project research is designed to inform management decisions related to channel re-engineering, flow modification, and pallid sturgeon population augmentation on the Missouri River and throughout the range of the species. Research and progress made through this project are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by the Comprehensive Sturgeon Research Project during 2014.

Effects of exogenous hormones on spermatogenesis in the male prairie dog (Cynomys ludovicianus).

PubMed

Foreman, D

1998-01-01

Male prairie dogs (Cynomys ludovicianus) breed anually and have complete testicular regression. Changes in the seminiferous tubules during the annual cycle have been described recently (Foreman, 1997). This is the first description of spermatogenesis in such a species. The definition of tubular stages during the cycle allows for evaluation of the effects of exogenous hormones, hemicastration, and hemicryptorchidism on spermatogenesis during the annual cycle. Hemicastration was performed during stages of the annual cycle to determine effects of exogenous hormones on remaining testes. Hemicryptorchidism was also done during stages of the annual cycle. FSH, LH, and testosterone were given in high and low doses for short- or long-term treatment periods during stages of the annual cycle. Testicular weights and counts of cell types in tubules of control and treated testes were made on testis tissues. Hemicastration during the out-of-season period does not cause compensatory hypertrophy of the remaining testis, but during recrudescence, hypertrophy of the remaining testis occurs. Hemicastration does not prevent loss of weight by the remaining testis during regression. The seminiferous epithelium of hemicryptorchid prairie dog testes shows damage during spermatogenic activity but not during testicular inactivity. Similarly, hemicryptorchid 15-day-old rat testes do not show damage from hemicryptorchidism. Long-term treatment with FSH preparations during testicular inactivity increased testis weights, spermatogonial proliferation, and spermatocyte differentiation in conjunction with Sertoli cell differentiation. Short-term treatments with low doses increased spermatogonial proliferation and abnormal meiotic activity. Both long- and short-term treatments with LH caused increased sloughing of germ cells and stimulated Leydig and Sertoli cells. Testosterone propionate injections stimulated Sertoli secretions but not Leydig cell activity. Hemicastration during inactivity does not stimulate gonadotropin secretion. Hemicryptorchidism does not affect tubular morphology during inactivity in either rats or prairie dogs. Prompt responses to FSH depend on scrotal location of the testis. FSH has its major effects on germ cell proliferation and differentiation, both directly and through activation of Sertoli cells, whereas LH affects Sertoli and Leydig cell activation but has no effect on germ cell activity. Testosterone activates Sertoli cells.

Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.

PubMed

Lindau, Alexandra; Härdtner, Carmen; Hergeth, Sonja P; Blanz, Kelly Daryll; Dufner, Bianca; Hoppe, Natalie; Anto-Michel, Nathaly; Kornemann, Jan; Zou, Jiadai; Gerhardt, Louisa M S; Heidt, Timo; Willecke, Florian; Geis, Serjosha; Stachon, Peter; Wolf, Dennis; Libby, Peter; Swirski, Filip K; Robbins, Clinton S; McPheat, William; Hawley, Shaun; Braddock, Martin; Gilsbach, Ralf; Hein, Lutz; von zur Mühlen, Constantin; Bode, Christoph; Zirlik, Andreas; Hilgendorf, Ingo

2016-03-01

Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6C(high) monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into macrophages that proliferate locally as disease progresses. Spleen tyrosine kinase (SYK) may participate in downstream signaling of various receptors that mediate these processes. We tested the effect of the SYK inhibitor fostamatinib on hypercholesterolemia-associated myelopoiesis and plaque formation in Apoe(-/-) mice during early and established atherosclerosis. Mice consuming a high cholesterol diet supplemented with fostamatinib for 8 weeks developed less atherosclerosis. Histologic and flow cytometric analysis of aortic tissue showed that fostamatinib reduced the content of Ly6C(high) monocytes and macrophages. SYK inhibition limited Ly6C(high) monocytosis through interference with GM-CSF/IL-3 stimulated myelopoiesis, attenuated cell adhesion to the intimal surface, and blocked M-CSF stimulated monocyte to macrophage differentiation. In Apoe(-/-) mice with established atherosclerosis, however, fostamatinib treatment did not limit macrophage accumulation or lesion progression despite a significant reduction in blood monocyte counts, as lesional macrophages continued to proliferate. Thus, inhibition of hypercholesterolemia-associated monocytosis, monocyte infiltration, and differentiation by SYK antagonism attenuates early atherogenesis but not established disease when local macrophage proliferation dominates lesion progression.

Proteomic analysis reveals the important roles of alpha-5-collagen and ATP5β during skin ulceration syndrome progression of sea cucumber Apostichopus japonicus.

PubMed

Zhao, Zelong; Jiang, Jingwei; Pan, Yongjia; Sun, Hongjuan; Guan, Xiaoyan; Gao, Shan; Chen, Zhong; Dong, Ying; Zhou, Zunchun

2018-03-20

Apostichopus japonicus is one of the most important aquaculture species in China. Skin ulceration syndrome (SUS) of sea cucumber is a common and serious disease affected the development of A. japonicus culture industry. To better understand the response mechanisms of A. japonicus during SUS progression, the protein variations in the body wall of A. japonicus at different stages of SUS were investigated by a comparative proteomic approach based on isobaric tags for relative and absolute quantification. A total of 1449 proteins were identified from the samples at different SUS stages. Among these proteins, 145 proteins were differentially expressed in the SUS-related samples compared to those of healthy A. japonicus. These differentially expressed proteins involved a wide range of functions. Among these differentially expressed proteins, only two proteins, alpha-5-collagen and an unknown function protein, were differentially expressed during the whole progression of SUS compared with healthy A. japonicus. In addition, ATP synthase subunit beta (ATP5β) interacted with a variety of proteins with different functions during the SUS progression. These results implied that alpha-5-collagen and ATP5β could play important roles during the SUS progression of A. japonicus. Our study provided a new sight to understand the molecular responses of sea cucumber during the SUS progression and accumulated data for the prevention of SUS in sea cucumber aquaculture. The current study aimed to reveal how the body wall of Apostichopus japonicus response to skin ulceration syndrome (SUS). To the best of our knowledge, this is the first proteomic study analyzing the differences in protein profile of sea cucumber during the whole SUS progression. By analyzing the expression differences of the proteome via isobaric labeling-based quantitative proteomic, we identified some proteins which may play important roles during the SUS progression. According to the enrichment analyses of these proteins based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, a draft view of how the sea cucumber affected by SUS has been drawn. The common and unique differentially expressed proteins by Venn analysis showed that alpha-5-collagen was down-regulated at all stages of SUS, which had the potential as a target component for the host-directed SUS therapy. In addition, ATP5β, a subunit of mitochondrial ATP synthase, interacting with a variety of proteins with different functions during the SUS progression. This result illustrated that energy production and metabolism could play an important role in the formation of skin ulceration and resistance to pathogens in sea cucumber. The results of this study will be helpful for researchers to gain insights into the complex molecular mechanism of SUS in sea cucumber. Copyright © 2018 Elsevier B.V. All rights reserved.

Midwest Transportation Consortium annual progress report : October 2001.

DOT National Transportation Integrated Search

2001-10-01

From the Director: Transportation assets are tremendously important from the perspective the performance of our national, : state, and regional economies. Few people comprehend the great impact it has on the overall economy. : Literally trillions of ...

10 CFR 603.885 - Updated program plans and budgets.

Code of Federal Regulations, 2011 CFR

2011-01-01

... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision requiring the recipient to annually prepare an updated technical plan for future conduct of the research...

Climate Ready Estuaries Progress Reports

EPA Pesticide Factsheets

Climate Ready Estuaries has supported adaptation activities in National Estuary Programs since 2008. In 2012, the program partnered with 23 NEPs, completed a pilot project with water utilities, and held workshops. Download annual reports from 2009-2012.

42 CFR 505.17 - Reporting requirements for meeting the conditions for loan forgiveness.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) HEALTH CARE INFRASTRUCTURE IMPROVEMENT PROGRAM... measure used to track the qualifying hospital's progress in meeting its plan goals. (b) Review of annual...

42 CFR 505.17 - Reporting requirements for meeting the conditions for loan forgiveness.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) HEALTH CARE INFRASTRUCTURE IMPROVEMENT PROGRAM... measure used to track the qualifying hospital's progress in meeting its plan goals. (b) Review of annual...

Physics Division annual progress report for period ending December 31, 1975. [ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1976-05-01

Separate abstracts were prepared for each of the data-containing sections of this report. Additional sections deal with publications, titles of papers presented at scientific and technical meetings, personnel, etc. (RWR)

77 FR 41791 - Proposed Collection; Comment Request; Prostate, Lung, Colorectal and Ovarian Cancer Screening...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-16

..., demographic and risk factor information may be used to analyze the differential effectiveness of cancer screening in high versus low risk individuals. Frequency of Response: Annually. Affected Public: Individuals...

5 CFR 550.904 - Authorization of hazard pay differential.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., without regard to whether the hazardous duty or physical hardship is grade controlling, unless payment of... the annual cost to the agency. (e) So that OPM can evaluate agencies' use of this authority and...

Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia.

PubMed

Rogalski, E; Cobia, D; Harrison, T M; Wieneke, C; Weintraub, S; Mesulam, M-M

2011-05-24

To examine the longitudinal course of primary progressive aphasia (PPA) over a 2-year period and to offer quantitative ranges of expected change that could be used to guide the design and evaluation of therapeutic intervention trials. Regional changes of cortical thickness and whole-brain cortical volume loss as well as neuropsychological language performance were assessed at baseline and 2 years later in 13 rigorously characterized patients who fulfilled research criteria for logopenic, agrammatic, and semantic PPA subtypes (6 PPA-L, 3 PPA-G, and 4 PPA-S). There was substantial progression of clinical deficits and cortical atrophy over 2 years. Neuropsychological language performance patterns lost the sharp distinctions that differentiated one PPA variant from another. Nonetheless, the subtype-specific differential impairment of word comprehension vs grammatical processing was largely maintained. Peak atrophy sites spread beyond the initial distinctive locations that characterized each of the 3 subtypes and displayed a more convergent distribution encompassing all 3 major components of the language network: the inferior frontal gyrus, the temporoparietal junction, and lateral temporal cortex. Despite the progression, overall peak atrophy remained lateralized to the left hemisphere. The results suggest that the unique features, which sharply differentiate the PPA variants at the early to middle stages, may lose their distinctiveness as the degeneration becomes more severe. Given the substantial atrophy over 2 years, PPA clinical trials may require fewer patients and shorter study durations than Alzheimer disease trials to detect significant therapeutic effects.

Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia

PubMed Central

Cobia, D.; Harrison, T.M.; Wieneke, C.; Weintraub, S.; Mesulam, M.-M.

2011-01-01

Objectives: To examine the longitudinal course of primary progressive aphasia (PPA) over a 2-year period and to offer quantitative ranges of expected change that could be used to guide the design and evaluation of therapeutic intervention trials. Methods: Regional changes of cortical thickness and whole-brain cortical volume loss as well as neuropsychological language performance were assessed at baseline and 2 years later in 13 rigorously characterized patients who fulfilled research criteria for logopenic, agrammatic, and semantic PPA subtypes (6 PPA-L, 3 PPA-G, and 4 PPA-S). Results: There was substantial progression of clinical deficits and cortical atrophy over 2 years. Neuropsychological language performance patterns lost the sharp distinctions that differentiated one PPA variant from another. Nonetheless, the subtype-specific differential impairment of word comprehension vs grammatical processing was largely maintained. Peak atrophy sites spread beyond the initial distinctive locations that characterized each of the 3 subtypes and displayed a more convergent distribution encompassing all 3 major components of the language network: the inferior frontal gyrus, the temporoparietal junction, and lateral temporal cortex. Despite the progression, overall peak atrophy remained lateralized to the left hemisphere. Conclusions: The results suggest that the unique features, which sharply differentiate the PPA variants at the early to middle stages, may lose their distinctiveness as the degeneration becomes more severe. Given the substantial atrophy over 2 years, PPA clinical trials may require fewer patients and shorter study durations than Alzheimer disease trials to detect significant therapeutic effects. PMID:21606451

Overexpression of protein kinase FA/GSK-3 alpha (a proline-directed protein kinase) correlates with human hepatoma dedifferentiation/progression.

PubMed

Yang, S D; Yu, J S; Yang, C C; Lee, S C; Lee, T T; Ni, M H; Kuan, C Y; Chen, H C

1996-05-01

Computer analysis of protein phosphorylation sites sequence revealed that transcriptional factors and viral oncoproteins are prime targets for regulation of proline-directed protein phosphorylation, suggesting an association of the proline-directed protein kinase (PDPK) family with neoplastic transformation and tumorigenesis. In this report, an immunoprecipitate activity assay of protein kinase FA/glycogen synthase kinase-3 alpha (kinase F(A)/GSK-3 alpha) (a member of PDPK family) has been optimized for human hepatoma and used to demonstrate for the first time significantly increased (P < 0.01) activity in poorly differentiated SK-Hep-1 hepatoma (24.2 +/- 2.8 units/mg) and moderately differentiated Mahlavu hepatoma (14.5 +/- 2.2 units/mg) when compared to well differentiated Hep 3B hepatoma (8.0 +/- 2.4 units/mg). Immunoblotting analysis revealed that increased activity of kinase FA/GSK-3 alpha is due to overexpression of the protein. Elevated kinase FA/GSK-3 alpha expression in human hepatoma biopsies relative to normal liver tissue was found to be even more profound. This kinase appeared to be fivefold overexpressed in well differentiated hepatoma and 13-fold overexpressed in poorly differentiated hepatoma when compared to normal liver tissue. Taken together, the results provide initial evidence that overexpression of kinase FA/GSK-3 alpha is involved in human hepatoma dedifferentiation/progression. Since kinase FA/GSK-3 alpha is a PDPK, the results further support a potential role of this kinase in human liver tumorigenesis, especially in its dedifferentiation/progression.

Cell Expansion During Directed Differentiation of Stem Cells Toward the Hepatic Lineage.

PubMed

Raju, Ravali; Chau, David; Cho, Dong Seong; Park, Yonsil; Verfaillie, Catherine M; Hu, Wei-Shou

2017-02-15

The differentiation of human pluripotent stem cells toward the hepatocyte lineage can potentially provide an unlimited source of functional hepatocytes for transplantation and extracorporeal bioartificial liver applications. It is anticipated that the quantities of cells needed for these applications will be in the order of 10 9 -10 10 cells, because of the size of the liver. An ideal differentiation protocol would be to enable directed differentiation to the hepatocyte lineage with simultaneous cell expansion. We introduced a cell expansion stage after the commitment of human embryonic stem cells to the endodermal lineage, to allow for at least an eightfold increase in cell number, with continuation of cell maturation toward the hepatocyte lineage. The progressive changes in the transcriptome were measured by expression array, and the expression dynamics of certain lineage markers was measured by mass cytometry during the differentiation and expansion process. The findings revealed that while cells were expanding they were also capable of progressing in their differentiation toward the hepatocyte lineage. In addition, our transcriptome, protein and functional studies, including albumin secretion, drug-induced CYP450 expression and urea production, all indicated that the hepatocyte-like cells obtained with or without cell expansion are very similar. This method of simultaneous cell expansion and hepatocyte differentiation should facilitate obtaining large quantities of cells for liver cell applications.

Chapter 10: Peak Demand and Time-Differentiated Energy Savings Cross-Cutting Protocol. The Uniform Methods Project: Methods for Determining Energy Efficiency Savings for Specific Measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurnik, Charles W; Stern, Frank; Spencer, Justin

Savings from electric energy efficiency measures and programs are often expressed in terms of annual energy and presented as kilowatt-hours per year (kWh/year). However, for a full assessment of the value of these savings, it is usually necessary to consider the measure or program's impact on peak demand as well as time-differentiated energy savings. This cross-cutting protocol describes methods for estimating the peak demand and time-differentiated energy impacts of measures implemented through energy efficiency programs.

Role of alpha- and beta-adrenergic receptors in cardiomyocyte differentiation from murine-induced pluripotent stem cells.

PubMed

Li, Xiao-Li; Zeng, Di; Chen, Yan; Ding, Lu; Li, Wen-Ju; Wei, Ting; Ou, Dong-Bo; Yan, Song; Wang, Bin; Zheng, Qiang-Sun

2017-02-01

Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adrenergic receptors (ARs) in stem cells after differentiation; however, roles of ARs in fate specification of stem cells, particularly in cardiomyocyte differentiation and development, have not been characterized. Murine-induced pluripotent stem cells (miPSCs) were cultured in hanging drops to form embryoid bodies, cells of which were then differentiated into cardiomyocytes. To determine whether ARs regulated miPSC differentiation into cardiac lineages, effects of the AR agonist, epinephrine (EPI), on miPSC differentiation and underlying signalling mechanisms, were evaluated. Treatment with EPI, robustly enhanced miPSC cardiac differentiation, as indicated by increased expression levels of cardiac-specific markers, GATA4, Nkx2.5 and Tnnt2. Although β-AR signalling is the foremost signalling pathway in cardiomyocytes, EPI-enhanced cardiac differentiation depended more on α-AR signalling than β-AR signalling. In addition, selective activation of α 1 -AR signalling with specific agonists induced vigorous cardiomyocyte differentiation, whereas selective activation of α 2 - or β-AR signalling induced no or less differentiation, respectively. EPI- and α 1 -AR-dependent cardiomyocyte differentiation from miPSCs occurred through specific promotion of CPC proliferation via the MEK-ERK1/2 pathway and regulation of miPS cell-cycle progression. These results demonstrate that activation of ARs, particularly of α 1 -ARs, promoted miPSC differentiation into cardiac lineages via MEK-ERK1/2 signalling. © 2016 John Wiley & Sons Ltd.

Clinical Investigation Program Annual Progress Report.

DTIC Science & Technology

1983-09-30

Antiemetics (A Phase II Study).(O) ............... 049 79/110 Evaluation of Local Anesthetic Skin Testing and Progressive Challenge in Patients with a History ...Associated with Oat Cell Carcinoma. J Assoc Mil Derm 8, 1982. Grimwood, R.E.: The History and Principles of Immunofluorescence. J Assn Mil Derm 9(1...December, 1981. ""’ PRESENTATIONS: 1.) Kindig, N.B.: D CO correction using PaCO back pressure predicted from venous bloo . Sfresented: Carl E

Annual Progress Report, Fiscal Year 1978 (U.S. Army Research Institute of Environmental Medicine, Natick, MA)

DTIC Science & Technology

1978-10-01

pulmonary ventilation via the " central chemoreceptors" (6.8) and to regulate cerebral blood flow (8,12). The " central chemoreceptors" for respiration are...decreases in illumination. Progress: The Hidden Shapes Test (I), the Maudsley Personality Inventory (2) and a personal history questionnaire were...hypoglycemia has been encountered occasionally in heatstroke but its pathogenesis is still uncertain. The contribution of central glucopenia to heatstroke coma

Safety and Tolerability of Everolimus as Second-line Treatment in Poorly Differentiated Neuroendocrine Carcinoma / Neuroendocrine Carcinoma G3 (WHO 2010) and Neuroendocrine Tumor G3 - an Investigator Initiated Phase II Study

ClinicalTrials.gov

2018-01-19

Poorly Differentiated Malignant Neuroendocrine Carcinoma; Neuroendocrine Carcinoma, Grade 3; Neuroendocrine Carcinoma, Grade 1 [Well-differentiated Neuroendocrine Carcinoma] That Switched to G3; Neuroendocrine Carcinoma, Grade 2 [Moderately Differentiated Neuroendocrine Carcinoma] That Switched to G3; Neuroendocrine Tumor, Grade 3 and Disease Progression as Measured by Response Evaluation Criteria in Solid Tumors (RECIST 1.1.)

IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells☆

PubMed Central

Ackerman, W.E.; Bulmer, J.N.; Carter, A.M.; Chaillet, J.R.; Chamley, L.; Chen, C.P.; Chuong, E.B.; Coleman, S.J.; Collet, G.P.; Croy, B.A.; de Mestre, A.M.; Dickinson, H.; Ducray, J.; Enders, A.C.; Fogarty, N.M.E.; Gauster, M.; Golos, T.; Haider, S.; Heazell, A.E.; Holland, O.J.; Huppertz, B.; Husebekk, A.; John, R.M.; Johnsen, G.M.; Jones, C.J.P.; Kalionis, B.; König, J.; Lorenzon, A.R.; Moffett, A.; de Mello, J.C. Moreira; Nuzzo, A.M.; Parham, P.; Parolini, O.; Petroff, M.G.; Pidoux, G.; Ramírez-Pinilla, M.P.; Robinson, W.P.; Rolfo, A.; Sadovsky, Y.; Soma, H.; Southcombe, J.H.; Tilburgs, T.; Lash, G.E.

2014-01-01

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2011 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology: 1) immunology; 2) epigenetics; 3) comparative placentation; 4) trophoblast differentiation; 5) stem cells. PMID:22154501

To Assure the Free Appropriate Public Education of All Children with Disabilities (Individuals with Disabilities Education Act, Section 618). Twenty-Second Annual Report to Congress on the Implementation of the Individuals with Disabilities Education Act. 2000.

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This 22nd annual report to Congress on the implementation of the Individuals with Disabilities Education Act 1997 (IDEA) begins with a special preface reflecting on the progress made in the 25 years since the initial passage of the law. Following the preface, Section 1 examines contextual and environmental factors such as the role of minority…

Annual research briefs, 1993. [Center for Turbulence Research

NASA Technical Reports Server (NTRS)

1993-01-01

The 1993 annual progress reports of the Research Fellow and students of the Center for Turbulence Research are included. The first group of reports are directed towards the theory and application of active control in turbulent flows including the development of a systematic mathematical procedure based on the Navier Stokes equations for flow control. The second group of reports are concerned with the prediction of turbulent flows. The remaining articles are devoted to turbulent reacting flows, turbulence physics, experiments, and simulations.

Annual Report in Support of Technical Development Plan 43-03X--Education and Training Development. Annual Report No. 4, November 11, 1972--November 15, 1973 on Phase 2.

ERIC Educational Resources Information Center

Marlowe, Edward; And Others

This is the fourth report in a series which describes the results and progress in a long-term program to develop a Data Management System (DMS) and a Student Management System (SMS) for use in the Naval Student Pilot Training System. The DMS will contain all of the student naval aviator's data files needed to support an improved student training…

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eudy, Leslie; Post, Matthew; Gikakis, Christina

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. Various stakeholders, including FCEB developers, transit agencies, and system integrators, have expressed the value of this annual status report, which provides a summary of results from evaluations performed by the National Renewable Energy Laboratory. The annual status report tracks the progress of the FCEB industry toward meeting technical targets, documents the lessons learned, and discusses the path forward for commercial viability of fuel cell technology for transit buses. Themore » 2015 summary results primarily focus on the most recent year for each demonstration, from August 2014 through July 2015. The results for these buses account for more than 1,045,000 miles traveled and 83,000 hours of fuel cell power system operation. The primary results presented in the report are from two demonstrations of fuel-cell-dominant bus designs: the Zero Emission Bay Area Demonstration Group led by Alameda-Contra Costa Transit District (AC Transit) in California and the American Fuel Cell Bus Project at SunLine Transit Agency in California.« less

The 20th Annual Prostate Cancer Foundation Scientific Retreat report.

PubMed

Miyahira, Andrea K; Simons, Jonathan W; Soule, Howard R

2014-06-01

The 20th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held from October 24 to 26, 2013, in National Harbor, Maryland. This event is held annually for the purpose of convening a diverse group of leading experimental and clinical researchers from academia, industry, and government to present and discuss critical and emerging topics relevant to prostate cancer (PCa) biology, and the diagnosis, prognosis, and treatment of PCa patients, with a focus on results that will lend to treatments for the most life-threatening stages of this disease. The themes that were highlighted at this year's event included: (i) mechanisms of PCa initiation and progression: cellular origins, neurons and neuroendocrine PCa, long non-coding RNAs, epigenetics, tumor cell metabolism, tumor-immune interactions, and novel molecular mechanisms; (ii) advancements in precision medicine strategies and predictive biomarkers of progression, survival, and drug sensitivities, including the analysis of circulating tumor cells and cell-free tumor DNA-new methods for liquid biopsies; (iii) new treatments including epigenomic therapy and immunotherapy, discovery of new treatment targets, and defining and targeting mechanisms of resistance to androgen-axis therapeutics; and (iv) new experimental and clinical epidemiology methods and techniques, including PCa population studies using patho-epidemiology. © 2014 Wiley Periodicals, Inc.

Evolutionary ecology of resprouting and seeding in fire-prone ecosystems

USGS Publications Warehouse

Pausas, Juli G.; Keeley, Jon E.

2014-01-01

There are two broad mechanisms by which plant populations persist under recurrent disturbances: resprouting from surviving tissues, and seedling recruitment. Species can have one of these mechanisms or both. However, a coherent framework explaining the differential evolutionary pressures driving these regeneration mechanisms is lacking. We propose a bottom-up approach in addressing this question that considers the relative survivorship of adults and juveniles in an evolutionary context, based on two assumptions. First, resprouting and seeding can be interpreted by analogy with annual versus perennial life histories; that is, if we consider disturbance cycles to be analogous to annual cycles, then resprouting species are analogous to the perennial life history with iteroparous reproduction, and obligate seeding species that survive disturbances solely through seed banks are analogous to the annual life history with semelparous reproduction. Secondly, changes in the selective regimes differentially modify the survival rates of adults and juveniles and thus the relative costs and benefits of resprouting versus seeding. Our approach provides a framework for understanding temporal and spatial variation in resprouting and seeding under crown-fire regimes. It accounts for patterns of coexistence and environmental changes that contribute to the evolution of seeding from resprouting ancestors.

MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors.

PubMed

Ware, Patrick L; Snow, Anthony N; Gvalani, Maya; Pettenati, Mark J; Qasem, Shadi A

2014-03-01

MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. Forty-six cases of liposarcoma in various sites were examined and included 22 WDLs, 14 DLLs, and 10 negative control subjects. The MDM2 amplification ratio (MDM2/CEP12) was lower in WDL (10.2) compared with DDL (18.3) cases (P = .0000002). An amplification ratio of 16 showed optimal sensitivity (0.86) and specificity (0.96) as a cutoff point for progression to DDL. Borderline areas, defined as tumors with increased cellularity and atypia but with preserved lipomatous differentiation, showed a significantly higher MDM2 ratio (17.5; P = .0007) compared with WDL. Central (retroperitoneal and intra-abdominal) tumors also showed a significantly higher MDM2 ratio than peripheral ones (P = .02). Differences in MDM2 amplification profiles among liposarcomas could help further define and predict progression to high-grade neoplasia.

Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia.

PubMed

Liu, Yao-Nan; Lu, Si-Yao; Yao, Jun

2017-09-01

The etiology of neuropsychiatric disorders, such as schizophrenia and bipolar disorder, usually involves complex combinations of genetic defects/variations and environmental impacts, which hindered, for a long time, research efforts based on animal models and patients' non-neuronal cells or post-mortem tissues. However, the development of human induced pluripotent stem cell (iPSC) technology by the Yamanaka group was immediately applied to establish cell research models for neuronal disorders. Since then, techniques to achieve highly efficient differentiation of different types of neural cells following iPSC modeling have made much progress. The fast-growing iPSC and neural differentiation techniques have brought valuable insights into the pathology and neurobiology of neuropsychiatric disorders. In this article, we first review the application of iPSC technology in modeling neuronal disorders and discuss the progress in the accompanying neural differentiation. Then, we summarize the progress in iPSC-based research that has been accomplished so far regarding schizophrenia and bipolar disorder. © 2017 The Authors. Psychiatry and Clinical Neurosciences © 2017 Japanese Society of Psychiatry and Neurology.

Prognostic value of circulating microRNAs in upper tract urinary carcinoma

PubMed Central

Ingelmo-Torres, Mercedes; Lozano, Juan José; Capitán, David; Alcaraz, Antonio; Mengual, Lourdes

2018-01-01

The identification of upper tract urinary carcinoma (UTUC) prognostic biomarkers is urgently needed to predict tumour progression. This study aimed to identify serum microRNAs (miRNAs) that may be useful as minimally invasive predictive biomarkers of tumour progression and survival in UTUC patients. To this end, 33 UTUC patients who underwent radical nephroureterectomy at the Hospital Clinic of Barcelona were prospectively included. Expression of 800 miRNAs was evaluated in serum samples from these patients using nCounter® miRNA Expression Assays. The study was divided into an initial discovery phase (n=12) and a validation phase (n=21). Cox regression analysis was used for survival analysis. The median follow-up (range) of the series was 42 months (9-100 months). In the discovery phase, 38 differentially expressed miRNAs were identified between progressing and non-progressing UTUC patients (p<0.05). Validation of these 38 miRNAs in an independent set of UTUC patients confirmed the differential expression in 18 of them (p<0.05). Cox Regression analysis showed miR-151b and pathological stage as significant prognostic factors for tumour progression (HR=0.33, p<0.001 and HR=2.62, p=0.006, respectively) and cancer specific survival (HR=0.25, p<0.001 and HR=3.98, p=0.003, respectively). Survival curves revealed that miR-151b is able to discriminate between two groups of UTUC patients with a highly significant different probability of tumour progression (p=0.006) and cancer specific survival (p=0.034). Although the data needs to be externally validated, miRNA analysis in serum appears to be a valuable prognostic tool in UTUC patients. Particularly, differential expression of miR-151b in serum may serve as a minimally invasive prognostic tool in UTUC. PMID:29682178

Prognostic value of circulating microRNAs in upper tract urinary carcinoma.

PubMed

Montalbo, Ruth; Izquierdo, Laura; Ingelmo-Torres, Mercedes; Lozano, Juan José; Capitán, David; Alcaraz, Antonio; Mengual, Lourdes

2018-03-30

The identification of upper tract urinary carcinoma (UTUC) prognostic biomarkers is urgently needed to predict tumour progression. This study aimed to identify serum microRNAs (miRNAs) that may be useful as minimally invasive predictive biomarkers of tumour progression and survival in UTUC patients. To this end, 33 UTUC patients who underwent radical nephroureterectomy at the Hospital Clinic of Barcelona were prospectively included. Expression of 800 miRNAs was evaluated in serum samples from these patients using nCounter® miRNA Expression Assays. The study was divided into an initial discovery phase (n=12) and a validation phase (n=21). Cox regression analysis was used for survival analysis. The median follow-up (range) of the series was 42 months (9-100 months). In the discovery phase, 38 differentially expressed miRNAs were identified between progressing and non-progressing UTUC patients (p<0.05). Validation of these 38 miRNAs in an independent set of UTUC patients confirmed the differential expression in 18 of them (p<0.05). Cox Regression analysis showed miR-151b and pathological stage as significant prognostic factors for tumour progression (HR=0.33, p<0.001 and HR=2.62, p=0.006, respectively) and cancer specific survival (HR=0.25, p<0.001 and HR=3.98, p=0.003, respectively). Survival curves revealed that miR-151b is able to discriminate between two groups of UTUC patients with a highly significant different probability of tumour progression (p=0.006) and cancer specific survival (p=0.034). Although the data needs to be externally validated, miRNA analysis in serum appears to be a valuable prognostic tool in UTUC patients. Particularly, differential expression of miR-151b in serum may serve as a minimally invasive prognostic tool in UTUC.

Recent progress in stem cell differentiation directed by material and mechanical cues.

PubMed

Lin, Xunxun; Shi, Yuan; Cao, Yilin; Liu, Wei

2016-02-02

Stem cells play essential roles in tissue regeneration in vivo via specific lineage differentiation induced by environmental factors. In the past, biochemical signals were the focus of induced stem cell differentiation. As reported by Engler et al (2006 Cell 126 677-89), biophysical signal mediated stem cell differentiation could also serve as an important inducer. With the advancement of material science, it becomes a possible strategy to generate active biophysical signals for directing stem cell fate through specially designed material microstructures. In the past five years, significant progress has been made in this field, and these designed biophysical signals include material elasticity/rigidity, micropatterned structure, extracellular matrix (ECM) coated materials, material transmitted extracellular mechanical force etc. A large number of investigations involved material directed differentiation of mesenchymal stem cells, neural stem/progenitor cells, adipose derived stem cells, hematopoietic stem/progenitor cells, embryonic stem cells and other cells. Hydrogel based materials were commonly used to create varied mechanical properties via modifying the ratio of different components, crosslinking levels, matrix concentration and conjugation with other components. Among them, polyacrylamide (PAM) and polydimethylsiloxane (PDMS) hydrogels remained the major types of material. Specially designed micropatterning was not only able to create a unique topographical surface to control cell shape, alignment, cell-cell and cell-matrix contact for basic stem cell biology study, but also could be integrated with 3D bioprinting to generate micropattered 3D structure and thus to induce stem cell based tissue regeneration. ECM coating on a specific topographical structure was capable of inducing even more specific and potent stem cell differentiation along with soluble factors and mechanical force. The article overviews the progress of the past five years in this particular field.

Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

PubMed Central

Rebeiro, Peter F; Cesar, Carina; Shepherd, Bryan E; De Boni, Raquel B; Cortés, Claudia P; Rodriguez, Fernanda; Belaunzarán-Zamudio, Pablo; Pape, Jean W; Padgett, Denis; Hoces, Daniel; McGowan, Catherine C; Cahn, Pedro

2016-01-01

Introduction We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS). Methods Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each). Female sex (risk ratio (RR)=0.97 vs. males) and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM)) were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96) significantly decreased the probability of cART compared with heterosexual transmission. Conclusions HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings. PMID:27065108

Midwest Transportation Consortium annual progress report : October 2000.

DOT National Transportation Integrated Search

2000-10-01

From the Director: The Midwest Transportation Consortium (MTC), the University Transportation Center serving the states : of Iowa, Kansas, Missouri, and Nebraska, had a very successful first year of operation. The MTC is a : complex partnership invol...

Metals and Ceramics Division Materials Sciences Program. Annual progress report for period ending December 31, 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stiegler, J.O.

1986-06-01

The report is divided into the following: structural characterization, high-temperature alloy research, structural ceramics, radiation effects, structure and properties of surfaces and interfaces, and collaborative research centers. (DLC)

78 FR 77109 - Agency Information Collection Activities; Comment Request; Race to the Top-District Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... implementing personalized learning environments, including narrative sections on progress and key performance... electronically through the Federal eRulemaking Portal at http://www.regulations.gov by selecting Docket ID number...

The Consortium for Plant Biotechnology Research, Inc. Semi-Annual Technical Report for April 1, 2000 - September 30, 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2000-10-02

Scientific progress reports submitted by university researchers conducting projects funded through CPBR and metrics reports submitted by industry sponsors that provided matching funds to the projects.

United States Transuranium and Uranium Registries. Annual report February 1, 2001--January 31, 2002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ehrhart, Susan M.; Filipy, Ronald E.

2002-07-01

This report documents the activities of the United States Transuranium and Uranium Registries (USTUR) from February 2001 through January 2002. Progress in continuing collaborations and several new collaborations is reviewed.

Development of an extended-burnup Mark B design. First semi-annual progress report, July-December 1978. Report BAW-1532-1. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-10-01

The primary objective of this program is to develop and demonstrate an improved PWR fuel assembly design capable of batch average burnups of 45,000-50,000 MWd/mtU. To accomplish this, a number of technical areas must be investigated to verify acceptable extended-burnup fuel performance. This report is the first semi-annual progress report for the program, and it describes work performed during the July-December 1978 time period. Efforts during this period included the definition of a preliminary design for a high-burnup fuel rod, physics analyses of extended-burnup fuel cycles, studies of the physics characteristics of changes in fuel assembly metal-to-water ratios, and developmentmore » of a design concept for post-irradiation examination equipment to be utilized in examining high-burnup lead-test assemblies.« less

Differential parental care by adult Mountain Plovers, Charadrius montanus

USGS Publications Warehouse

Dinsmore, S.J.; Knopf, F.L.

2005-01-01

We studied chick survival of the Mountain Plover (Charadrius montanus) in Montana and found that chicks tended by females had higher survival rates than chicks tended by males, and that chick survival generally increased during the nesting season. Differences in chick survival were most pronounced early in the nesting season, and may be related to a larger sample of nests during this period. When compared to information about the nest survival of male- and female-tended plover nests, our chick data suggest a trade-off for adult plovers between the egg and chick phases of reproduction. Because Mountain Plover pairs have clutches at two nests at two different locations and show differential success between the sexes during the egg and chick phases, we offer that the Mountain Plover breeding system favours optimizing annual recruitment in a dynamic ecologic setting driven by annually unpredictable drought, grazing, and predation pressures.

Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch.

PubMed

Kranjec, Christian; Holleywood, Christina; Libert, Diane; Griffin, Heather; Mahmood, Radma; Isaacson, Erin; Doorbar, John

2017-08-01

In stratified epithelia such as the epidermis, homeostasis is maintained by the proliferation of cells in the lower epithelial layers and the concomitant loss of differentiated cells from the epithelial surface. These differentiating keratinocytes progressively stratify and form a self-regenerating multi-layered barrier that protects the underlying dermis. In such tissue, the continual loss and replacement of differentiated cells also limits the accumulation of oncogenic mutations within the tissue. Inactivating mutations in key driver genes, such as TP53 and NOTCH1, reduce the proportion of differentiating cells allowing for the long-term persistence of expanding mutant clones in the tissue. Here we show that through the expression of E6, HPV-16 prevents the early fate commitment of human keratinocytes towards differentiation and confers a strong growth advantage to human keratinocytes. When E6 is expressed either alone or with E7, it promotes keratinocyte proliferation at high cell densities, through the combined inactivation of p53 and Notch1. In organotypic raft culture, the activity of E6 is restricted to the basal layer of the epithelium and is enhanced during the progression from productive to abortive or transforming HPV-16 infection. Consistent with this, the expression of p53 and cleaved Notch1 becomes progressively more disrupted, and is associated with increased basal cell density and reduced commitment to differentiation. The expression of cleaved Notch1 is similarly disrupted also in HPV-16-positive cervical lesions, depending on neoplastic grade. When taken together, these data depict an important role of high-risk E6 in promoting the persistence of infected keratinocytes in the basal and parabasal layers through the inactivation of gene products that are commonly mutated in non-HPV-associated neoplastic squamous epithelia. © 2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. © 2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Incidence, Risk Factors, and Outcomes of Colorectal Cancer in Patients With Ulcerative Colitis With Low-Grade Dysplasia: A Systematic Review and Meta-analysis.

PubMed

Fumery, Mathurin; Dulai, Parambir S; Gupta, Samir; Prokop, Larry J; Ramamoorthy, Sonia; Sandborn, William J; Singh, Siddharth

2017-05-01

Little is known about outcomes of patients with ulcerative colitis with low-grade dysplasia (UC-LGD). We estimated the incidence of and risk factors for progression to colorectal cancer (CRC) in cohorts of patients with UC-LGD who underwent surveillance (surveillance cohort), and the prevalence of dysplasia-related findings among patients who underwent colectomy for UC-LGD (surgical cohort). We performed a systematic literature review through June 1, 2016, to identify cohort studies of adults with UC-LGD. We estimated pooled incidence rates of CRC and risk factors associated with dysplasia progression in surveillance cohorts, and prevalence of synchronous advanced neoplasia (CRC and/or high-grade dysplasia) in surgical cohorts. In 14 surveillance cohort studies of 671 patients with UC-LGD (52 developed CRC), the pooled annual incidence of CRC was 0.8% (95% confidence interval [CI], 0.4-1.3); the pooled annual incidence of advanced neoplasia was 1.8% (95% CI, 0.9-2.7). Risk of CRC was higher when LGD was diagnosed by expert gastrointestinal pathologist (1.5%) than by community pathologists (0.2%). Factors significantly associated with dysplasia progression were concomitant primary sclerosing cholangitis (odds ratio [OR], 3.4; 95% CI, 1.5-7.8), invisible dysplasia (vs visible dysplasia; OR, 1.9; 95% CI, 1.0-3.4), distal location (vs proximal location; OR, 2.0; 95% CI, 1.1-3.7), and multifocal dysplasia (vs unifocal dysplasia; OR, 3.5; 95% CI, 1.5-8.5). In 12 surgical cohort studies of 450 patients who underwent colectomy for UC-LGD, 34 patients had synchronous CRC (pooled prevalence, 17%; 95% CI, 8-33). In a systematic review of the literature, we found that among patients with UC-LGD under surveillance, the annual incidence of progression to CRC was 0.8%; differences in rates of LGD diagnosis varied with pathologists' level of expertise. Concomitant primary sclerosing cholangitis, invisible dysplasia, distal location, and multifocal LGD are high-risk features associated with dysplasia progression. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

[Poorly differentiated thyroid carcinomas: new therapeutic considerations].

PubMed

Graf, Hans

2005-10-01

For most differentiated thyroid carcinomas, as papillary and follicular carcinomas, following total thyroidectomy and 131I therapy for thyroid remnant ablation, treatment with thyroid hormones to suppress TSH levels will reduce the growth of any remaining thyroid cancer cells, and thyroid cell-specific radiation therapy will either cure or control the disease. Thyroid carcinomas are considered poorly differentiated when they start to lose such functions as iodine uptake and thyrotropin-dependence for growth and production of thyroid proteins like NIS, thyroglobulin and desiodases. One of the greatest challenges in the management of patients with follicular cell-derived thyroid cancer is the treatment of tumors that progressed despite surgery, (131)I and T4 suppression of TSH. With the better knowledge of the abnormal molecular signaling in thyroid cancer cells, actually known targeted cancer therapies, directed against molecules involved in neoplastic transformation, are being used. As the critical molecular requirements for tumor initiation, maintenance and progression are identified, combination therapies with targeted agents acting on each of them will improve the treatment of poorly differentiated thyroid carcinoma.

From embryonic stem cells to functioning germ cells: science, clinical and ethical perspectives.

PubMed

Kiatpongsan, Sorapop

2007-10-01

Embryonic stem cells have been well recognized as cells having a versatile potential to differentiate into all types of cells in the body including germ cells. There are many research studies focusing on the differentiation processes and protocols to derive various types of somatic cells from embryonic stem cells. However, germ cells have unique differentiation process and developmental pathway compared with somatic cells. Consequently, they will require different differentiation protocols and special culture techniques. More understanding and established in vitro systems for gametogenesis will greatly contribute to further progression of knowledge and technology in germ cell biology, reproductive biology and reproductive medicine. Moreover if oocytes can be efficiently produced in vitro, this will play an important role on progression in nuclear transfer and nuclear reprogramming technology. The present article will provide concise review on past important discoveries, current ongoing studies and future views of this challenging research area. An ethical perspective has also been proposed to give comprehensive summary and viewpoint for future clinical application.

Processes of arroyo filling in northern New Mexico, USA

USGS Publications Warehouse

Friedman, Jonathan M.; Vincent, Kirk R.; Griffin, Eleanor R.; Scott, Michael L.; Shafroth, Patrick B.; Auble, Gregor T.

2015-01-01

We documented arroyo evolution at the tree, trench, and arroyo scales along the lower Rio Puerco and Chaco Wash in northern New Mexico, USA. We excavated 29 buried living woody plants and used burial signatures in their annual rings to date stratigraphy in four trenches across the arroyos. Then, we reconstructed the history of arroyo evolution by combining trench data with arroyo-scale information from aerial imagery, light detection and ranging (LiDAR), longitudinal profiles, and repeat surveys of cross sections. Burial signatures in annual rings of salt cedar and willow dated sedimentary beds greater than 30 cm thick with annual precision. Along both arroyos, incision occurred until the 1930s in association with extreme high flows, and subsequent filling involved vegetation development, channel narrowing, increased sinuosity, and finally vertical aggradation. A strongly depositional sediment transport regime interacted with floodplain shrubs to produce a characteristic narrow, trapezoidal channel. The 55 km study reach along the Rio Puerco demonstrated upstream progression of arroyo widening and filling, but not of arroyo incision, channel narrowing, or floodplain vegetation development. We conclude that the occurrence of upstream progression within large basins like the Rio Puerco makes precise synchrony across basins impossible. Arroyo wall retreat is now mostly limited to locations where meanders impinge on the arroyo wall, forming hairpin bends, for which entry to and exit from the wall are stationary. Average annual sediment storage within the Rio Puerco study reach between 1955 and 2005 was 4.8 × 105 t/yr, 16% of the average annual suspended sediment yield, and 24% of the long-term bedrock denudation rate. At this rate, the arroyo would fill in 310 yr.

International VLBI Service for Geodesy and Astrometry 2000 Annual Report

NASA Technical Reports Server (NTRS)

Vandenberg, N. R. (Editor); Baver, K. D. (Editor); Smith, David E. (Technical Monitor)

2000-01-01

This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2000 Annual Report documents the work of the IVS components for the period March 1, 1999 (the official inauguration date of IVS) through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000. This book and the web site are organized as follows: (1) The first section contains general information about IVS, a map showing the location of the components, information about the Directing Board members, and the report of the IVS Chair; (2) The second section of Special Reports contains a status report of the IVS Working Group on GPS phase center mapping, a reproduction of the resolution making IVS a Service of the International Astronomical Union (IAU), and a reprint of the VLBI Standard Interface (VSI); (3) The next seven sections hold the component reports from the Coordinators, Network Stations, Operation Centers, Correlators, Data Centers, Analysis Centers, and Technology Development Centers; and (4) The last section includes reference information about IVS: the Terms of Reference, the lists of Member and Affiliated organizations, the IVS Associate Member list, a complete list of IVS components, the list of institutions contributing to this report, and a list of acronyms. The 2000 Annual Report demonstrates the vitality of the IVS and the outstanding progress we have made during our first 22 months.

Removal of kidney stones by extracorporeal shock wave lithotripsy is associated with delayed progression of chronic kidney disease.

PubMed

Yoo, Dong Eun; Han, Seung Hyeok; Oh, Hyung Jung; Kim, Seung Jun; Shin, Dong Ho; Lee, Mi Jung; Yoo, Tae-Hyun; Kang, Shin-Wook; Choi, Kyu Hun

2012-07-01

This study aimed to elucidate whether stone removal by extracorporeal shock wave lithotripsy (ESWL) is associated with delayed chronic kidney disease (CKD) progression. We conducted a retrospective analysis of 131 nephrolithiasis patients with stage 3 and 4 CKD. We collected baseline clinical and laboratory data, kidney stone characteristics, and history of receiving ESWL. We classified study patients into two groups according to whether they underwent ESWL or not (Non-ESWL group vs. ESWL group). We initially compared annual estimated glomerular filtration rate (eGFR) changes of Non-ESWL group with those of ESWL group before undergoing ESWL. In the next step, we sought to compare annual eGFR changes in the same patients before and after ESWL. Finally, we compared annual eGFR changes between success and failure groups among patients undergoing ESWL. The mean age of the patients was 62 years and 72.5% were male. The mean observation period was 3.2 years. Non-ESWL group and ESWL group before undergoing ESWL showed similar annual eGFR changes (-1.75±6.5 vs. -1.63±7.2 mL/min/1.73 m²/year, p=0.425). However, eGFR declined slower after undergoing ESWL than before ESWL (annual eGFR changes, -0.29±6.1 vs. -1.63±7.2 mL/min/1.73 m²/year, p<0.05). In addition, among patients in ESWL group, eGFR declined faster in the failure group than in the success group (annual eGFR change, -1.01±4.7 vs. -0.05±5.2 mL/min/1.73 m²/year, p<0.05). Our results suggest that stone removal by ESWL is associated with delayed deterioration of renal function in CKD patients with nephrolithiasis.

FY 2005 Annual Progress Report for the DOE Hydrogen Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

In cooperation with industry, academia, national laboratories, and other government agencies, the Department of Energy's Hydrogen Program is advancing the state of hydrogen and fuel cell technologies in support of the President's Hydrogen Fuel Initiative. The initiative seeks to develop hydrogen, fuel cell, and infrastructure technologies needed to make it practical and cost-effective for Americans to choose to use fuel cell vehicles by 2020. Significant progress was made in fiscal year 2005 toward that goal.

Modeling the Magnetic and Thermal Structure of Active Regions: 1st Year 1st Semi-Annual Progress Report

NASA Technical Reports Server (NTRS)

Mikic, Zoran

2003-01-01

This report covers technical progress during the first six months of the first year of NASA SR&T contract "Modeling the Magnetic and Thermal Structure of Active Regions", NASW-03008, between NASA and Science Applications International Corporation, and covers the period January 14, 2003 to July 13, 2003. Under this contract SAIC has conducted research into theoretical modeling of the properties of active regions using the MHD model.

Acoustics Discipline Overview

NASA Technical Reports Server (NTRS)

Envia, Edmane; Thomas, Russell

2007-01-01

As part of the Fundamental Aeronautics Program Annual Review, a summary of the progress made in 2007 in acoustics research under the Subsonic Fixed Wing project is given. The presentation describes highlights from in-house and external activities including partnerships and NRA-funded research with industry and academia. Brief progress reports from all acoustics Phase 1 NRAs are also included as are outlines of the planned activities for 2008 and all Phase 2 NRAs. N+1 and N+2 technology paths outlined for Subsonic Fixed Wing noise targets. NRA Round 1 progressing with focus on prediction method advancement. NRA Round 2 initiating work focused on N+2 technology, prediction methods, and validation. Excellent partnerships in progress supporting N+1 technology targets and providing key data sets.

Midwest Transportation Consortium annual progress report : October 2002.

DOT National Transportation Integrated Search

2002-10-01

From the Director: For the past three years, the Midwest Transportation Consortium (MTC) has focused its efforts in : supporting the development and use of asset management systems in transportation. The MTCs main : focus is on human capital devel...

29 CFR 1960.71 - Agency annual reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... individual agency progress and problems in correcting unsafe or unhealthful working conditions, and... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) BASIC PROGRAM ELEMENTS FOR FEDERAL EMPLOYEE OCCUPATIONAL SAFETY AND HEALTH PROGRAMS AND RELATED...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Satyapal, Sunita

The 2011 Annual Progress Report summarizes fiscal year 2011 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; education; market transformation; and systems analysis.

UAS Integration in the NAS FY15 Annual Review

NASA Technical Reports Server (NTRS)

Grindle, Laurie; Randall, Debra; Hackenburg, Davis

2015-01-01

This presentation gives insight into the research activities and efforts being executed in order to integrate unmanned aircraft systems into the national airspace system. This briefing is to inform others of the UAS-NAS progress and future directions.

Fuel Cell Buses in U.S. Transit Fleets : Current Status 2014

DOT National Transportation Integrated Search

2014-12-03

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. Various stakeholders, including d...

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

The 2013 Annual Progress Report summarizes fiscal year 2013 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

Case Study of Childhood Disintegrative Disorder--Heller's Syndrome.

ERIC Educational Resources Information Center

Bray, Melissa A.; Kehle, Thomas J.; Theodore, Lea A.; Broudy, Matthew S.

2002-01-01

Discusses the case of a 25-year-old male with childhood disintegrative disorder (CDD), or Heller's syndrome, in terms of differential diagnosis, progression of the disorder, and suggestions for home- and school-based interventions. Documents the progressive deterioration of cognitive and social competencies. (Contains 23 references.) (GCP)

Using the Malcolm Baldrige "are we making progress" survey for organizational self-assessment and performance improvement.

PubMed

Shields, Judith A; Jennings, Jerry L

2013-01-01

A national healthcare company applied the Malcolm Baldrige Criteria for Performance Excellence and its "Are We Making Progress?" survey as an annual organizational self-assessment to identify areas for improvement. For 6 years, Liberty Healthcare Corporation reviewed the survey results on an annual basis to analyze positive and negative trends, monitor company progress toward targeted goals and develop new initiatives to address emerging areas for improvement. As such, the survey provided a simple and inexpensive methodology to gain useful information from employees at all levels and from multiple service sites and business sectors. In particular, it provided a valuable framework for assessing and improving the employees' commitment to the company's mission and values, high standards and ethics, quality of work, and customer satisfaction. The methodology also helped the company to incorporate the philosophy and principles of continuous quality improvement in a unified fashion. Corporate and local leadership used the same measure to evaluate the performance of individual programs relative to each other, to the company as a whole, and to the "best practices" standard of highly successful companies that received the Malcolm Baldrige National Quality Award. © 2012 National Association for Healthcare Quality.

Midline signals regulate retinal neurogenesis in zebrafish.

PubMed

Masai, I; Stemple, D L; Okamoto, H; Wilson, S W

2000-08-01

In zebrafish, neuronal differentiation progresses across the retina in a pattern that is reminiscent of the neurogenic wave that sweeps across the developing eye in Drosophila. We show that expression of a zebrafish homolog of Drosophila atonal, ath5, sweeps across the eye predicting the wave of neuronal differentiation. By analyzing the regulation of ath5 expression, we have elucidated the mechanisms that regulate initiation and spread of neurogenesis in the retina. ath5 expression is lost in Nodal pathway mutant embryos lacking axial tissues that include the prechordal plate. A likely role for axial tissue is to induce optic stalk cells that subsequently regulate ath5 expression. Our results suggest that a series of inductive events, initiated from the prechordal plate and progressing from the optic stalks, regulates the spread of neuronal differentiation across the zebrafish retina.

Gender differences in national assessment of educational progress science items: What does i don't know really mean?

NASA Astrophysics Data System (ADS)

Linn, Marcia C.; de Benedictis, Tina; Delucchi, Kevin; Harris, Abigail; Stage, Elizabeth

The National Assessment of Educational Progress Science Assessment has consistently revealed small gender differences on science content items but not on science inquiry items. This assessment differs from others in that respondents can choose I don't know rather than guessing. This paper examines explanations for the gender differences including (a) differential prior instruction, (b) differential response to uncertainty and use of the I don't know response, (c) differential response to figurally presented items, and (d) different attitudes towards science. Of these possible explanations, the first two received support. Females are more likely to use the I don't know response, especially for items with physical science content or masculine themes such as football. To ameliorate this situation we need more effective science instruction and more gender-neutral assessment items.

The effect of inhaled corticosteroids on the development of emphysema in smokers assessed by annual computed tomography.

PubMed

Shaker, Saher B; Dirksen, Asger; Ulrik, Charlotte S; Hestad, Marianne; Stavngaard, Trine; Laursen, Lars C; Maltbaek, Niels; Clementsen, Paul; Skjaerbaek, Nanna; Nielsen, Lars; Stoel, Berend; Skovgaard, Lene T; Tonnesen, Philip

2009-04-01

The objective was to evaluate the effect of inhaled corticosteroids on disease progression in smokers with moderate to severe chronic obstructive pulmonary disease (COPD), as assessed by annual computed tomography (CT) using lung density (LD) measurements. Two hundred and fifty-four current smokers with COPD were randomised to treatment with either an inhaled corticosteroids (ICS), budesonide 400 microg bid, or placebo. COPD was defined as FEV(1) < or = 70% pred, FEV(1)/FVC < or = 60% and no reversibility to beta(2)-agonists and oral corticosteroids. The patients were followed for 2-4 years with biannual spirometry and annual CT and comprehensive lung function tests (LFT). CT images were analysed using Pulmo-CMS software. LD was derived from a pixel-density histogram of the whole lung as the 15th percentile density (PD15) and the relative area of emphysema at a threshold of -910 Hounsfield units (RA-910), and both were volume-adjusted to predicted total lung capacity. At baseline, mean age was 64 years and 64 years; mean number of pack-years was 56 and 56; mean FEV(1) was 1.53 L (51% pred) and 1.53 L (53% pred); mean PD15 was 103 g/L and 104 g/L; and mean RA-910 was 14% and 13%, respectively, for the budesonide and placebo groups. The annual fall in PD15 was -1.12 g/L in the budesonide group and -1.81 g/L in the placebo group (p = 0.09); the annual increase in RA-910 was 0.4% in the budesonide group and 1.1% in the placebo group (p = 0.02). There was no difference in annual decline in FEV(1) between ICS (-54 mL) and placebo (-56 mL) (p = 0.89). Long-term budesonide inhalation shows a non-significant trend towards reducing the progression of emphysema as determined by the CT-derived 15th percentile lung density from annual CT scans in current smokers with moderate to severe COPD.

The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression.

PubMed

Middelbeek, Jeroen; Vrenken, Kirsten; Visser, Daan; Lasonder, Edwin; Koster, Jan; Jalink, Kees; Clark, Kristopher; van Leeuwen, Frank N

2016-11-01

Neuroblastoma is the second-most common solid tumor in children and originates from poorly differentiated neural crest-derived progenitors. Although most advanced stage metastatic neuroblastoma patients initially respond to treatment, a therapy resistant pool of poorly differentiated cells frequently arises, leading to refractory disease. A lack of insight into the molecular mechanisms that underlie neuroblastoma progression hampers the development of effective new therapies for these patients. Normal neural crest development and maturation is guided by physical interactions between the cell and its surroundings, in addition to soluble factors such as growth factors. This mechanical crosstalk is mediated by actin-based adhesion structures and cell protrusions that probe the cellular environment to modulate migration, proliferation, survival and differentiation. Whereas such signals preserve cellular quiescence in non-malignant cells, perturbed adhesion signaling promotes de-differentiation, uncontrolled cell proliferation, tissue invasion and therapy resistance. We previously reported that high expression levels of the channel-kinase TRPM7, a protein that maintains the progenitor state of embryonic neural crest cells, are closely associated with progenitor-like features of tumor cells, accompanied by extensive cytoskeletal reorganization and adhesion remodeling. To define mechanisms by which TRPM7 may contribute to neuroblastoma progression, we applied a proteomics approach to identify TRPM7 interacting proteins. We show that TRPM7 is part of a large complex of proteins, many of which function in cytoskeletal organization, cell protrusion formation and adhesion dynamics. Expression of a subset of these TRPM7 interacting proteins strongly correlates with neuroblastoma progression in independent neuroblastoma patient datasets. Thus, TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions. Copyright © 2016 Elsevier GmbH. All rights reserved.

Modelling gene expression profiles related to prostate tumor progression using binary states

PubMed Central

2013-01-01

Background Cancer is a complex disease commonly characterized by the disrupted activity of several cancer-related genes such as oncogenes and tumor-suppressor genes. Previous studies suggest that the process of tumor progression to malignancy is dynamic and can be traced by changes in gene expression. Despite the enormous efforts made for differential expression detection and biomarker discovery, few methods have been designed to model the gene expression level to tumor stage during malignancy progression. Such models could help us understand the dynamics and simplify or reveal the complexity of tumor progression. Methods We have modeled an on-off state of gene activation per sample then per stage to select gene expression profiles associated to tumor progression. The selection is guided by statistical significance of profiles based on random permutated datasets. Results We show that our method identifies expected profiles corresponding to oncogenes and tumor suppressor genes in a prostate tumor progression dataset. Comparisons with other methods support our findings and indicate that a considerable proportion of significant profiles is not found by other statistical tests commonly used to detect differential expression between tumor stages nor found by other tailored methods. Ontology and pathway analysis concurred with these findings. Conclusions Results suggest that our methodology may be a valuable tool to study tumor malignancy progression, which might reveal novel cancer therapies. PMID:23721350

Increased expression of enhancer of Zeste Homolog 2 (EZH2) differentiates squamous cell carcinoma from normal skin and actinic keratosis.

PubMed

Xie, Qiang; Wang, Hongbei; Heilman, Edward R; Walsh, Michael G; Haseeb, M A; Gupta, Raavi

2014-01-01

Enhancer of Zeste Homolog 2 (EZH2) is a polycomb group protein that has been shown to be involved in the progression of multiple human cancers including melanoma. The expression of EZH2 in normal skin and in pre-malignant and malignant cutaneous squamous cell carcinoma (SCC) has not been studied. We examined the expression of EZH2 in normal skin, actinic keratosis (AK), SCC in situ, well-differentiated (SCC-WD), moderately-differentiated (SCC-MD) and poorly-differentiated SCC (SCC-PD) to ascertain whether EZH2 expression differentiates these conditions. Immunohistochemical staining for EZH2 was performed on formalin-fixed paraffin-embedded biopsies and a tissue microarray containing normal skin, AK, SCC in situ, and SCC of different grades. In comparison to the normal skin, EZH2 expression in actinic keratosis was increased (p=0.03). Similarly, EZH2 expression in all of the neoplastic conditions studied (SCC in situ, SCC-WD, SCC-MD and SCC-PD) was greatly increased in comparison to both the normal skin and actinic keratosis (p≤0.001). EZH2 expression increases incrementally from normal skin to AK and further to SCC, suggesting a role for EZH2 in the progression and differentiation of SCC. EZH2 expression may be used as a diagnostic marker for differentiating SCC from AK or normal skin.

Cell Expansion During Directed Differentiation of Stem Cells Toward the Hepatic Lineage

PubMed Central

Raju, Ravali; Chau, David; Cho, Dong Seong; Park, Yonsil; Verfaillie, Catherine M.

2017-01-01

The differentiation of human pluripotent stem cells toward the hepatocyte lineage can potentially provide an unlimited source of functional hepatocytes for transplantation and extracorporeal bioartificial liver applications. It is anticipated that the quantities of cells needed for these applications will be in the order of 109–1010 cells, because of the size of the liver. An ideal differentiation protocol would be to enable directed differentiation to the hepatocyte lineage with simultaneous cell expansion. We introduced a cell expansion stage after the commitment of human embryonic stem cells to the endodermal lineage, to allow for at least an eightfold increase in cell number, with continuation of cell maturation toward the hepatocyte lineage. The progressive changes in the transcriptome were measured by expression array, and the expression dynamics of certain lineage markers was measured by mass cytometry during the differentiation and expansion process. The findings revealed that while cells were expanding they were also capable of progressing in their differentiation toward the hepatocyte lineage. In addition, our transcriptome, protein and functional studies, including albumin secretion, drug-induced CYP450 expression and urea production, all indicated that the hepatocyte-like cells obtained with or without cell expansion are very similar. This method of simultaneous cell expansion and hepatocyte differentiation should facilitate obtaining large quantities of cells for liver cell applications. PMID:27806669

Representation of the equatorial stratospheric quasi-biennial oscillation in EOF phase space. [EOF (empirical orthogonal function)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallace, J.M.; Panetta, R.L.; Estberg, J.

1993-06-15

A 35-year record of monthly mean zonal wind data for the equatorial stratosphere is represented in terms of a vector (radius and phase angle) in a two-dimensional phase space defined by the normalized expansion coefficients of the two leading empirical orthogonal functions (EOFs) of the vertical structure. The tip of the vector completes one nearly circular loop during each cycle of the quasi-biennial oscillation (QBO). Hence, its position and rate of progress along the orbit of the point provide a measure of the instantaneous amplitude and rate of phase progression of the QBO. Although the phase of the QBO bearsmore » little if any relation to calendar month, the rate of phase progression is strongly modulated by the first and second harmonics of the annual cycle, with a primary maximum in April/May, in agreement with previous studies based on the descent rates of easterly and westerly regimes. A simple linear prediction model is developed for the rate of phase progression, based on the phase of the QBO and the phase of the annual cycle. The model is capable of hindcasting the phase of the QBO to within a specified degree of accuracy approximately 50% longer than a default scheme based on the mean observed rate of phase progression of the QBO (1 cycle per 28.1 months). If the seasonal dependence is ignored, the prediction equation corresponds to the [open quotes]circle map,[close quotes] for which an extensive literature exists in dynamical systems theory. 17 refs., 14 figs., 2 tabs.« less

Annual survival estimation of migratory songbirds confounded by incomplete breeding site-fidelity: Study designs that may help

USGS Publications Warehouse

Marshall, M.R.; Diefenbach, D.R.; Wood, L.A.; Cooper, R.J.

2004-01-01

Many species of bird exhibit varying degrees of site-fidelity to the previous year's territory or breeding area, a phenomenon we refer to as incomplete breeding site-fidelity. If the territory they occupy is located beyond the bounds of the study area or search area (i.e., they have emigrated from the study area), the bird will go undetected and is therefore indistinguishable from dead individuals in capture-mark-recapture studies. Differential emigration rates confound inferences regarding differences in survival between sexes and among species if apparent survival rates are used as estimates of true survival. Moreover, the bias introduced by using apparent survival rates for true survival rates can have profound effects on the predictions of population persistence through time, source/sink dynamics, and other aspects of life-history theory. We investigated four study design and analysis approaches that result in apparent survival estimates that are closer to true survival estimates. Our motivation for this research stemmed from a multi-year capture-recapture study of Prothonotary Warblers (Protonotaria citrea) on multiple study plots within a larger landscape of suitable breeding habitat where substantial inter-annual movements of marked individuals among neighboring study plots was documented. We wished to quantify the effects of this type of movement on annual survival estimation. The first two study designs we investigated involved marking birds in a core area and resighting them in the core as well as an area surrounding the core. For the first of these two designs, we demonstrated that as the resighting area surrounding the core gets progressively larger, and more "emigrants" are resighted, apparent survival estimates begin to approximate true survival rates (bias < 0.01). However, given observed inter-annual movements of birds, it is likely to be logistically impractical to resight birds on sufficiently large surrounding areas to minimize bias. Therefore, as an alternative protocol, we analyzed the data with subsets of three progressively larger areas surrounding the core. The data subsets provided four estimates of apparent survival that asymptotically approached true survival. This study design and analytical approach is likely to be logistically feasible in field settings and yields estimates of true survival unbiased (bias < 0.03) by incomplete breeding site-fidelity over a range of inter-annual territory movement patterns. The third approach we investigated used a robust design data collection and analysis approach. This approach resulted in estimates of survival that were unbiased (bias < 0.02), but were very imprecise and likely would not yield reliable estimates in field situations. The fourth approach utilized a fixed study area size, but modeled detection probability as a function of bird proximity to the study plot boundary (e.g., those birds closest to the edge are more likely to emigrate). This approach also resulted in estimates of survival that were unbiased (bias < 0.02), but because the individual covariates were normalized, the average capture probability was 0.50, and thus did not provide an accurate estimate of the true capture probability. Our results show that the core-area with surrounding resight-only can provide estimates of survival that are not biased by the effects of incomplete breeding site-fidelity. ?? 2004 Museu de Cie??ncies Naturals.

2013 Geothermal Technologies Office Peer Review Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geothermal Technologies Office

Geothermal Technologies Office conducted its annual program peer review in April of 2013. The review provided an independent, expert evaluation of the technical progress and merit of GTO-funded projects. Further, the review was a forum for feedback and recommendations on future GTO strategic planning. During the course of the peer review, DOE-funded projects were evaluated for 1) their contribution to the mission and goals of the GTO and 2) their progress against stated project objectives. Principal Investigators (PIs) came together in sessions organized by topic “tracks” to disseminate information, progress, and results to a panel of independent experts as wellmore » as attendees.« less

Handedness and language learning disability differentially distribute in progressive aphasia variants.

PubMed

Miller, Zachary A; Mandelli, Maria Luisa; Rankin, Katherine P; Henry, Maya L; Babiak, Miranda C; Frazier, Darvis T; Lobach, Iryna V; Bettcher, Brianne M; Wu, Teresa Q; Rabinovici, Gil D; Graff-Radford, Neill R; Miller, Bruce L; Gorno-Tempini, Maria Luisa

2013-11-01

Primary progressive aphasia is a neurodegenerative clinical syndrome that presents in adulthood with an isolated, progressive language disorder. Three main clinical/anatomical variants have been described, each associated with distinctive pathology. A high frequency of neurodevelopmental learning disability in primary progressive aphasia has been reported. Because the disorder is heterogeneous with different patterns of cognitive, anatomical and biological involvement, we sought to identify whether learning disability had a predilection for one or more of the primary progressive aphasia subtypes. We screened the University of California San Francisco Memory and Aging Center's primary progressive aphasia cohort (n = 198) for history of language-related learning disability as well as hand preference, which has associations with learning disability. The study included logopenic (n = 48), non-fluent (n = 54) and semantic (n = 96) variant primary progressive aphasias. We investigated whether the presence of learning disability or non-right-handedness was associated with differential effects on demographic, neuropsychological and neuroimaging features of primary progressive aphasia. We showed that a high frequency of learning disability was present only in the logopenic group (χ(2) = 15.17, P < 0.001) and (χ(2) = 11.51, P < 0.001) compared with semantic and non-fluent populations. In this group, learning disability was associated with earlier onset of disease, more isolated language symptoms, and more focal pattern of left posterior temporoparietal atrophy. Non-right-handedness was instead over-represented in the semantic group, at nearly twice the prevalence of the general population (χ(2) = 6.34, P = 0.01). Within semantic variant primary progressive aphasia the right-handed and non-right-handed cohorts appeared homogeneous on imaging, cognitive profile, and structural analysis of brain symmetry. Lastly, the non-fluent group showed no increase in learning disability or non-right-handedness. Logopenic variant primary progressive aphasia and developmental dyslexia both manifest with phonological disturbances and posterior temporal involvement. Learning disability might confer vulnerability of this network to early-onset, focal Alzheimer's pathology. Left-handedness has been described as a proxy for atypical brain hemispheric lateralization. As non-right-handedness was increased only in the semantic group, anomalous lateralization mechanisms might instead be related to frontotemporal lobar degeneration with abnormal TARDBP. Taken together, this study suggests that neurodevelopmental signatures impart differential trajectories towards neurodegenerative disease.

The Impact of the Measures of Academic Progress (MAP) Program on Student Reading Achievement

ERIC Educational Resources Information Center

Cordray, David S.; Pion, Georgine M.; Brandt, Chris; Molefe, Ayrin

2013-01-01

One of the most widely used commercially available systems incorporating benchmark assessment and training in differentiated instruction is the Northwest Evaluation Association's (NWEA) Measures of Academic Progress (MAP) program. The MAP program involves two components: (1) computer-adaptive assessments administered to students three to four…

Genistein-mediated inhibition of mammary stromal adipocyte differentiation limits expansion of mammary stem/progenitor cells by paracrine signaling

USDA-ARS?s Scientific Manuscript database

Mammary adiposity may contribute to breast cancer development and progression by releasing cytokines and other inflammatory mediators that promote mammary epithelial proliferation. We evaluated the effects of soy isoflavone genistein (GEN) on the adipogenic differentiation of a SV40-immortalized mou...

Degree Progress of Women Doctoral Students: Factors that Constrain, Facilitate, and Differentiate

ERIC Educational Resources Information Center

Maher, Michelle A.; Ford, Martin E.; Thompson, Candace M.

2004-01-01

Using survey and qualitative data, this study identified emergent themes that remain consistent across or differentiate among reports of women earning their doctoral degree relatively quickly ("early-finishers") and those taking considerably longer ("late-finishers"). Emergent themes included commitment to timely degree completion, faculty…

In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression.

PubMed

Mayo, Clara; Lloreta, Josep; Real, Francisco X; Mayol, Xavier

2007-07-01

Tumor cell dedifferentiation-such as the loss of cell-to-cell adhesion in epithelial tumors-is associated with tumor progression. To better understand the mechanisms that maintain carcinoma cells in a differentiated state, we have dissected in vitro differentiation pathways in the mucus-secretor HT-29 M6 colon cancer cell line, which spontaneously differentiates in postconfluent cultures. By lowering the extracellular calcium concentration to levels that prevent intercellular adhesion and epithelial polarization, our results reveal that differentiation is calcium-dependent and involves: (i) a process of cell cycle exit to G(0) and (ii) the induction of a transcriptional program of differentiation gene expression (i.e., mucins MUC1 and MUC5AC, and the apical membrane peptidase DPPIV). In calcium-deprived, non-differentiated postconfluent cultures, differentiation gene promoters are repressed by a trichostatin A (TSA)-sensitive mechanism, indicating that loss of gene expression by dedifferentiation is driven by histone deacetylases (HDAC). Since TSA treatment or extracellular calcium restoration allow gene promoter activation to similar levels, we suggest that induction of differentiation is one mechanism of HDAC inhibitor antitumor action. Moreover, transcriptional de-repression can also be induced in non-differentiating culture conditions by overexpressing the cyclin-dependent kinase inhibitor p27(KIP1), which is normally induced during spontaneous differentiation. Since p27(KIP1) downregulation in colon cancer is associated with poor prognosis independently of tumor cell division rates, we propose that p27 (KIP1) may prevent tumor progression by, at least in part, enhancing the expression of some differentiation genes. Therefore, the HT-29 M6 model allows the identification of some basic mechanisms of cancer cell differentiation control, so far revealing HDAC and p27(KIP1) as key regulatory factors of differentiation gene expression.

First annual report SHRP C103 task 4 : rapid repair techniques.

DOT National Transportation Integrated Search

1989-01-01

The objective of task four is to develop technically and economically feasible methods of concrete bridge deck protection, rehabilitation, and replacement. The objective of the task will be accomplished through a progression of six subtasks. The subt...

State of the Lab Address

ScienceCinema

King, Alex

2018-05-07

In his third-annual State of the Lab address, Ames Laboratory Director Alex King called the past year one of "quiet but strong progress" and called for Ames Laboratory to continue to build on its strengths while responding to changing expectations for energy research.

Presentation of Institutional Results Reports, 2001.

ERIC Educational Resources Information Center

Illinois State Board of Higher Education, Springfield.

"The Illinois Commitment: Partnerships, Opportunities, and Excellence" requires an annual submission of a Results Report from higher education institutions and agencies to provide evidence of progress toward the six statewide goals: economic growth, teaching and learning, affordability, access and diversity, high expectations and…

State of the Lab Address

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, Alex

2010-01-01

In his third-annual State of the Lab address, Ames Laboratory Director Alex King called the past year one of "quiet but strong progress" and called for Ames Laboratory to continue to build on its strengths while responding to changing expectations for energy research.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

This annual report on fusion energy discusses the progress on work in the following main topics: toroidal confinement experiments; atomic physics and plasma diagnostics development; plasma theory and computing; plasma-materials interactions; plasma technology; superconducting magnet development; fusion engineering design center; materials research and development; and neutron transport. (LSP)

First Annual Symposium. Volume 1: Plenary Session

NASA Technical Reports Server (NTRS)

1989-01-01

Presentations from the symposium are presented. The progress of the Center for Space Construction is reviewed to promote technology transfer from the University of Colorado at Boulder to the national aerospace community. This symposium was heavily weighted toward plans and methodology.

ANNUAL REPORT, JULY 1, 1960

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1961-10-31

Research facilities, general construction progress, research activities, and administration are discussed and a financial statement is given. Fairly detailed accounts are given of research programs in the fields of physics, accelerator development, instrumentation, applied mathematics, chemistry, nuclear engineering, biology, and medicine. (M.C.G.)

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2017

DOT National Transportation Integrated Search

2017-11-01

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. The report provides a summary of ...

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2016

DOT National Transportation Integrated Search

2016-11-01

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. The report provides a summary of ...

Annual progress report

NASA Technical Reports Server (NTRS)

Duric, Nebojsa

1992-01-01

The emission components of spiral galaxies between 12 microns and 90 cm are identified. Additionally, an attempt to understand the relationships between them was made. The specific goal was to gain some understanding on the nature of the radio-infrared correlation. The results are summarized.

UAS Integration in the NAS Project - FY 14 Annual Review

NASA Technical Reports Server (NTRS)

Grindle, Laurie; Randall, Debra; Hackenberg, Davis

2014-01-01

This briefing gives insight into the research activities and efforts being executed in order to integrate unmanned aircraft systems into the national airspace system. This briefing is to inform others of the UAS-NAS Projects progress and future directions.

Fuel Cell Buses in U.S. Transit Fleets : Current Status 2015

DOT National Transportation Integrated Search

2015-12-01

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. The report provides a summary of ...

FY2009 Annual Progress Report for Energy Storage Research and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2010-01-19

The energy storage research and development effort within the VT Program is responsible for researching and improving advanced batteries and ultracapacitors for a wide range of vehicle applications, including HEVs, PHEVs, EVs, and fuel cell vehicles (FCVs).

Interplanting woody nurse crops promotes differential growth of black walnut saplings

Treesearch

J. O. Dawson; J. W. Van Sambeek

1993-01-01

Interplanting black walnut (Juglans nigra) with four different nitrogen fixing, woody nurse crops (Alnus glutinosa, Elaeagnus umbellata, E. angustifolia or Caragana arborescens) increased annual walnut height and stem diameter (dbh) growth overall by as much as 50% and...

40 CFR 98.3 - What are the general monitoring, reporting, recordkeeping and verification requirements of this...

Code of Federal Regulations, 2013 CFR

2013-07-01

... chosen, you must report: (i) Annual emissions aggregated for all GHG from all applicable source... element (e.g., the orifice plate), or when there is only a differential pressure transmitter in close...

40 CFR 98.3 - What are the general monitoring, reporting, recordkeeping and verification requirements of this...

Code of Federal Regulations, 2011 CFR

2011-07-01

... the latter reporting option is chosen, you must report: (i) Annual emissions aggregated for all GHG... primary element (e.g., the orifice plate), or when there is only a differential pressure transmitter in...

Theoretical Studies in Chemical Kinetics - Annual Report, 1970.

DOE R&D Accomplishments Database

Karplus, Martin

1970-10-01

The research performed includes (a) Alkali-Halide, Alkali-Halide (MX, M?X?) Exchange Reactions; (b) Inversion Problem; (c) Quantum Mechanics of Scattering Processes, (d) Transition State Analysis of Classical Trajectories, (e) Differential Cross Sections from Classical Trajectories; and (f) Other Studies.

Waste Isolation Pilot Plant Annual Site Environmental Report for 2014. Emended

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2015-09-01

The purpose of the Waste Isolation Pilot Plant (WIPP) Annual Site Environmental Report for 2014 (ASER) is to provide information required by U.S. Department of Energy (DOE) Order 231.1B, Environment, Safety, and Health Reporting. Specifically, the ASER presents summary environmental data to: Characterize site environmental management performance; Summarize environmental occurrences and responses reported during the calendar year (CY); Confirm compliance with environmental standards and requirements; Highlight significant environmental accomplishments, including progress toward the DOE environmental sustainability goals made through implementation of the WIPP Environmental Management System (EMS).

Annual Research Briefs, 1990

NASA Technical Reports Server (NTRS)

1991-01-01

The 1990 annual progress reports of the Research Fellows and students of the Center for Turbulent Research (CTR) are included. It is intended primarily as a contractor report to NASA, Ames Research Center. In addition, numerous CTR Manuscript Reports were published last year. The purpose of the CTR Manuscript Series is to expedite the dissemination of research results by the CTR staff. The CTR is devoted to the fundamental study of turbulent flow; its objectives are to produce advances in physical understanding of turbulence, in turbulence modeling and simulation, and in turbulence control.

Electric and Hybrid Vehicles Program. Sixteenth annual report to Congress for fiscal year 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-08-01

This report describes the progress achieved in developing electric and hybrid vehicle technologies, beginning with highlights of recent accomplishments in FY 1992. Detailed descriptions are provided of program activities during FY 1992 in the areas of battery, fuel cell, and propulsion system development, and testing and evaluation of new technology in fleet site operations and in laboratories. This Annual Report also contains a status report on incentives and use of foreign components, as well as a list of publications resulting from the DOE program.

Physics of the Cosmos Program Annual Technology Report

NASA Technical Reports Server (NTRS)

Pham, Bruce Thai; Cardiff, Ann H.

2015-01-01

What's in this Report? What's New? This fifth Program Annual Technology Report (PATR) summarizes the Programs technology development activities for fiscal year (FY) 2015. The PATR serves four purposes.1. Summarize the technology gaps identified by the astrophysics community;2. Present the results of this years technology gap prioritization by the PCOS Technology Management Board (TMB);3. Report on newly funded PCOS Strategic Astrophysics Technology (SAT) projects; and4. Detail progress, current status, and activities planned for the coming year for all technologies supported by PCOS Supporting Research and Technology (SRT) funding in FY 2015. .

A Report of Progress. Annual Report of the NFE Network Project: Operating a Clearinghouse on NFE Information (September 1981-August 1982) and Semi-Annual Reports of the NFE Network Project: Providing Technical Assistance in Creating LDC National/Regional Information Centers (September 1981-February 1982; March 1982-August 1982).

ERIC Educational Resources Information Center

Pigozzi, Mary Joy

This report describes the clearinghouse activities of the Non-Formal Education (NFE) Information Center from September 1981 through August 1982 and details efforts to strengthen the capacity of selected NFE resource centers in Africa, Asia, and Latin America. It first addresses the decision to extend the NFE Network Project, and then turns to the…

Moderate climate signature in cranial anatomy of late holocene human populations from Southern South America.

PubMed

Paula Menéndez, Lumila

2018-02-01

The aim of this study is to analyze the association between cranial variation and climate in order to discuss their role during the diversification of southern South American populations. Therefore, the specific objectives are: (1) to explore the spatial pattern of cranial variation with regard to the climatic diversity of the region, and (2) to evaluate the differential impact that the climatic factors may have had on the shape and size of the diverse cranial structures studied. The variation in shape and size of 361 crania was studied, registering 62 3D landmarks that capture shape and size variation in the face, cranial vault, and base. Mean, minimum, and maximum annual temperature, as well as mean annual precipitation, but also diet and altitude, were matched for each population sample. A PCA, as well as spatial statistical techniques, including kriging, regression, and multimodel inference were employed. The facial skeleton size presents a latitudinal pattern which is partially associated with temperature diversity. Both diet and altitude are the variables that mainly explain the skull shape variation, although mean annual temperature also plays a role. The association between climate factors and cranial variation is low to moderate, mean annual temperature explains almost 40% of the entire skull, facial skeleton and cranial vault shape variation, while annual precipitation and minimum annual temperature only contribute to the morphological variation when considered together with maximum annual temperature. The cranial base is the structure less associated with climate diversity. These results suggest that climate factors may have had a partial impact on the facial and vault shape, and therefore contributed moderately to the diversification of southern South American populations, while diet and altitude might have had a stronger impact. Therefore, cranial variation at the southern cone has been shaped both by random and nonrandom factors. Particularly, the influence of climate on skull shape has probably been the result of directional selection. This study supports that, although cranial vault is the cranial structure more associated to mean annual temperature, the impact of climate signature on morphology decreases when populations from extreme cold environments are excluded from the analysis. Additionally, it shows that the extent of the geographical scales analyzed, as well as differential sampling may lead to different results regarding the role of ecological factors and evolutionary processes on cranial morphology. © 2017 Wiley Periodicals, Inc.

Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease.

PubMed

Day, Gregory S; Lim, Tae Sung; Hassenstab, Jason; Goate, Alison M; Grant, Elizabeth A; Roe, Catherine M; Cairns, Nigel J; Morris, John C

2017-03-28

To identify clinical features that reliably differentiate individuals with cognitive impairment due to corticobasal degeneration (CBD) and Alzheimer disease (AD). Clinical features were compared between individuals with autopsy-proven CBD (n = 17) and AD (n = 16). All individuals presented with prominent cognitive complaints and were evaluated annually with semistructured interviews, detailed neurologic examinations, and neuropsychological testing. Substantial overlap was observed between individuals with dementia due to CBD and AD concerning presenting complaints, median (range) duration of symptoms before assessment (CBD = 3.0 [0-5.0] years, AD = 2.5 [0-8.0] years; p = 0.96), and median (range) baseline dementia severity (Clinical Dementia Rating Sum of Boxes: CBD = 3.5 [0-12.0], AD = 4.25 [0.5-9.0], p = 0.49). Subsequent emergence of asymmetric motor/sensory signs, hyperreflexia, gait abnormalities, parkinsonism, falls, urinary incontinence, and extraocular movement abnormalities identified individuals with CBD, with ≥3 discriminating features detected in 80% of individuals within 3.1 years (95% confidence interval 2.9-3.3) of the initial assessment. Individuals with CBD exhibited accelerated worsening of illness severity and declines in episodic memory, executive functioning, and letter fluency. Semiquantitative pathologic assessment revealed prominent tau pathology within the frontal and parietal lobes of CBD cases. Comorbid AD neuropathologic change was present in 59% (10 of 17) of CBD cases but did not associate with the clinical phenotype, rate of dementia progression, or dementia duration. CBD may mimic AD dementia early in its disease course. Interval screening for discriminating clinical features may improve antemortem diagnosis in individuals with CBD and prominent cognitive symptoms. © 2017 American Academy of Neurology.

Parameterization of GCM subgrid nonprecipitating cumulus and stratocumulus clouds using stochastic/phenomenological methods. Annual technical progress report, 1 December 1992--30 November 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stull, R.B.

1993-08-27

This document is a progress report to the USDOE Atmospheric Radiation and Measurement Program (ARM). The overall project goal is to relate subgrid-cumulus-cloud formation, coverage, and population characteristics to statistical properties of surface-layer air, which in turn are modulated by heterogeneous land-usage within GCM-grid-box-size regions. The motivation is to improve the understanding and prediction of climate change by more accurately describing radiative and cloud processes.

Annual Research Progress Report, Fiscal Year 1988. Volume 2. (Brooke Army Medical Center)

DTIC Science & Technology

1988-10-01

Phase III. (0) SWOG 8221 Treatment of Advanced Bladder Cancer with Preoperative Irradi- 362 ation and Radical Cystectomy vs. Radical Cystectomy Alone...Disease, Phase II. (0) POG 8731 Phase II Study of Low-dose "Continuous" Oral Methotrexate in 530 the Treatment of Children with Progressive or Recurrent...the other will receive a diet high in protein and carbohydrates but with minimal fiber. The remainder of the study will be conducted as outlined in the

International Space Station Electrodynamic Tether Reboost Study

NASA Technical Reports Server (NTRS)

Johnson, L.; Herrmann, M.

1998-01-01

The International Space Station (ISS) will require periodic reboost due to atmospheric aerodynamic drag. This is nominally achieved through the use of thruster firings by the attached Progress M spacecraft. Many Progress flights to the ISS are required annually. Electrodynamic tethers provide an attractive alternative in that they can provide periodic reboost or continuous drag cancellation using no consumables, propellant, nor conventional propulsion elements. The system could also serve as an emergency backup reboost system used only in the event resupply and reboost are delayed for some reason.

Annual Research Progress Report Fiscal Year 1990. Volume 1. Department of Clinical Investigation (Brooke Army Medical Center)

DTIC Science & Technology

1990-10-01

granulomE , Arch. Dermatol., (in press). Low, G. J. Ionizing radiation-induced pemphigus. Arch. Dermatol., (in press). McCollough, M. L. Dominant...the severity of their headache on a linear pain scale as well as a verbal scale. Patients were questioned as to whether they had received medications...occurred either by phone or in the Neurologist’s office, using the same verbal and linear scales. Progress: In all, six patients were entered into the

Proceedings of the Annual Conference of the Military Testing Association (23rd) held at Arlington, Virginia on 25-30 October 1981. Volume 2

DTIC Science & Technology

1981-10-01

differentiated the high from low performers on * the criterion. Once a total score based on the differentiating items was computed, this score was... high school or worked a certain number of hours while in school, perform better on the FST, receive higher ratings on training school criteria and...closets are not related to performance on the FST, even though they would have a high probability of correlating with job proficiency measures. From

The Effect of Atmospheric Diabatic Heating on Low-Frequency Oscillations.

NASA Astrophysics Data System (ADS)

Yen, Ming-Cheng

1990-01-01

A diagnostic scheme is devised to illustrate a chain relationship between diabatic heating and planetary -scale divergent and rotational circulations. The scheme consists of the velocity-potential (chi) maintenance equation, which relates diabatic heating and velocity potential, and the streamfunction (psi ) budget equation, which depicts the streamfunction tendency caused by the imbalance between streamfunction tendencies induced by vorticity advection and source. The proposed scheme is employed to examine the effect of tropical diabatic heating on the annual variation of subtropical jet streams. Furthermore, the chi -maintenance analysis is used to examine how the 30-60 day oscillation of planetary-scale divergent circulation is maintained; and the psi-budget analysis is performed to illustrate how the 30-60 day velocity potential (~{chi}) mode interacts with the upper-level monsoon flow to induce the 30-60 day oscillation of the tropical easterly jet. It was found that annual variations of both tropical diabatic heating and planetary-scale divergent circulation exhibit an annual in-phase seesaw oscillation between the winter and summer hemispheres. The annual variation of subtropical jet streams is caused by the adjustment of atmospheric rotational flow through planetary-scale divergent circulation in response to the annual cycle of tropical diabatic heating. The chi-maintenance equation is expressed as chi = chi _sp{rm Q}{.} - chi_{rm HA} , where chi_sp{rm Q}{.} and chi_ {rm HA} are the effects of vertical differential diabatic and adiabatic heating, respectively. The 30-60 day chi oscillation is shown to be primarily maintained by the differential diabatic heating effect, which can be inferred from the H _{rm VD} anomalies, the Laplician of the filtered chi_sp{rm Q}{.} anomalies. The resemblance of the H_{rm VD} and OLR anomalies in terms of the geographic distributions indicates that the differential diabatic heating effect maintaining the 30-60 day chi oscillation is attributable to the latent heat released by cumulus convection. The synoptic relationship among (~ {chi}, nabla~ {chi}) (200 mb), OLR and ~{psi} (200 mb) makes clear the synchronization of the 30-60 day oscillation of the tropical easterly jet and the Somali jet. The significant outcome of the psi-budget analysis demonstrates that the 30-60 day oscillation of the southern part of the tropical easterly jet is a response of the upper-level monsoon circulation to the eastward propagating ~{chi} mode.

Lessons in microbial geochemistry from the Coal Oil Point seep field: progress as prospects.

NASA Astrophysics Data System (ADS)

Valentine, D. L.; Kinnaman, F.; Wardlaw, G.; Redmond, M.; Ding, H.; Kimball, J.; Busso, L.; Larson, A.

2005-12-01

The hydrocarbon seeps located offshore Coal Oil Point, Santa Barbara, CA, are estimated to emit 1010 grams of methane and 50 thousand barrels of oil annually, and are among the most prolific in the world. The seep field spans a range of shelf depths and many of the seeps are accessible by SCUBA, making this an ideal location to investigate the impact of microbes on the biogeochemical cycling of methane and other hydrocarbons. With funding provided by the National Science Foundation, the Minerals Management Service and the Petroleum Research Fund, we have begun to investigate the interactions between microbes, hydrocarbon distributions, and environmental dynamics in the seep environment. This presentation will provide an overview of Coal Oil Point seep field and the biogeochemical research being conducted there. Several topics will be incorporated including i) the dynamics of oil and gas seepage, ii) the microbial consumption of methane, ethane, propane, butane and crude oil, iii) the distribution and composition of microbial mats, iv) redox differentiation in seep sediments and the importance of advection, and v) the development of experimental tools for the investigation of seep environments. Prospects for future biochemical research in the Coal Oil Point seep field will also be discussed.

Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq.

PubMed

Maeda, Shingo; Tomiyasu, Hirotaka; Tsuboi, Masaya; Inoue, Akiko; Ishihara, Genki; Uchikai, Takao; Chambers, James K; Uchida, Kazuyuki; Yonezawa, Tomohiro; Matsuki, Naoaki

2018-04-27

Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is necessary to improve our understanding of progression, diagnosis, and treatment of iUC. Companion canines are a preferred animal model of iUC due to spontaneous tumor development and similarity to human disease in terms of histopathology, metastatic behavior, and treatment response. However, the comprehensive molecular characterization of canine iUC is not well documented. In this study, we performed transcriptome analysis of tissue samples from canine iUC and normal bladders using an RNA sequencing (RNA-Seq) approach to identify key molecular pathways in canine iUC. Total RNA was extracted from bladder tissues of 11 dogs with iUC and five healthy dogs, and RNA-Seq was conducted. Ingenuity Pathway Analysis (IPA) was used to assign differentially expressed genes to known upstream regulators and functional networks. Differential gene expression analysis of the RNA-Seq data revealed 2531 differentially expressed genes, comprising 1007 upregulated and 1524 downregulated genes, in canine iUC. IPA revealed that the most activated upstream regulator was PTGER2 (encoding the prostaglandin E 2 receptor EP2), which is consistent with the therapeutic efficiency of cyclooxygenase inhibitors in canine iUC. Similar to human iUC, canine iUC exhibited upregulated ERBB2 and downregulated TP53 pathways. Biological functions associated with cancer, cell proliferation, and leukocyte migration were predicted to be activated, while muscle functions were predicted to be inhibited, indicating muscle-invasive tumor property. Our data confirmed similarities in gene expression patterns between canine and human iUC and identified potential therapeutic targets (PTGER2, ERBB2, CCND1, Vegf, and EGFR), suggesting the value of naturally occurring canine iUC as a relevant animal model for human iUC.

Payer Perspectives on Patient-Reported Outcomes in Health Care Decision Making: Oncology Examples.

PubMed

Brogan, Andrew P; DeMuro, Carla; Barrett, Amy M; D'Alessio, Denise; Bal, Vasudha; Hogue, Susan L

2017-02-01

Health authorities and payers increasingly recognize the importance of patient perspectives and patient-reported outcomes (PROs) in health care decision making. However, given the broad variety of PRO endpoints included in clinical programs and variations in the timing of PRO data collection and country-specific needs, the role of PRO data in reimbursement decisions requires characterization. To (a) determine the effect of PRO data on market access and reimbursement decisions for oncology products in multiple markets and (b) assess the effect of PRO data collected after clinical progression on payer decision making. A 3-part assessment (targeted literature review, qualitative one-on-one interviews, and online survey) was undertaken. Published literature was identified through searches in PubMed/MEDLINE and Embase. In addition, a targeted search was conducted of health technology assessment (HTA) agency websites in the United States, the United Kingdom, France, and Germany. Qualitative one-on-one interviews were conducted with 16 payers from the RTI Health Solutions global advisory panel in 14 markets (Australia, Brazil, France, Germany, Italy, South Korea, Netherlands, Poland, Spain, Sweden, Taiwan, Turkey, the United Kingdom, and the United States [n = 3]). Of the 200 payers and payer advisors from the global advisory panel invited to participate in the online survey, 20 respondents (China, France, Germany, Spain [n = 2], Taiwan, the United Kingdom, and the United States [n = 13]) completed the survey, and 6 respondents (Australia, South Korea, and the United States [n = 4]) partially completed the survey. Reviews of the literature and publicly available HTAs and reimbursement decisions suggested that HTA bodies and payers have varying experience with and confidence in PRO data. Payers participating in the survey indicated that PRO data may be especially influential in oncology compared with other therapeutic areas. Payers surveyed offered little differentiation by cancer type in the importance of PRO data but felt that it was most important to collect PRO data in phase 3 and postmarketing studies. Payers surveyed also anticipated an increasing significance for PRO data over the next 5-10 years. Characteristics of PRO data that maximize influence on payer decision making were reported to be (a) quality, well-controlled, and transparent PRO evidence; (b) psychometric validation of the PRO measure in targeted populations; and (c) publication in peer-reviewed journals. In markets with decentralized health care decision making, PRO data currently have more influence at the local level. Inclusion of PRO data in cancer treatment guidelines is key for centralized markets. Payers surveyed generally considered collecting PRO data postprogression to be useful. Of the 16 interviewees, 11 indicated that it is worthwhile to collect PRO data postprogression and that positive PRO data may support continued therapy at the physician's discretion upon regulatory approval, even in progressive disease. PRO data may help to differentiate treatments, particularly after clinical progression in oncology. Payers worldwide recognize high-quality PRO data as a key component of their decision-making process and anticipate the growing importance of PRO data in the future. This study and preparation of this article were funded by Novartis Pharmaceuticals. This research was performed under a research contract between RTI Health Solutions and Novartis Pharmaceuticals. Brogan, Hogue, Demuro, and Barrett are employees of RTI Health Solutions. D'Alessio and Bal are employees of Novartis Pharmaceuticals. Study concept and design were contributed by DeMuro, Barrett, Bal, and Hogue. Brogan and Hogue took the lead in data collection, assisted by DeMuro and Bal. Data interpretation was performed by Brogan and Hogue, assisted by the other authors. The manuscript was written by D'Alessio and Brogan, along with the other authors, and revised primarily by Brogan, along with Hogue and assisted by the other authors. The abstract for this article was presented as a research poster at the following meetings: Hogue SL, Brogan A P, De Muro C, D'Alessio D, Bal V. Patient-reported outcomes (PRO) in post-progression oncology: implications in health technology assessments and payer decision making. Poster presented at the ISPOR 18th Annual European Meeting; November 7-11, 2015. Milan, Italy. Hogue SL, Brogan AP, De Muro C, D'Alessio D, Bal V. Influence of patient-reported outcomes (PRO) on market access decisions in markets with centralized healthcare systems. Poster presented at the ISPOR 18th Annual European Meeting; November 7-11, 2015. Milan, Italy. Hogue SL, Brogan AP, De Muro C, Barrett A, D'Alessio D, Bal V. Influence of patient-reported outcomes on market access decisions in decentralized markets (Brazil, Italy, Spain and the United States). Poster presented at the ISPOR 20th Annual Meeting; May 16-20, 2015. Philadelphia PA. Hogue SL, Brogan A P, De Muro C, Barrett A, McLeod L, D'Alessio D, et al. Payer Perspectives of Patient-Reported Outcomes Data: An Online Assessment. Poster presented at the ISOQOL 22nd Annual Meeting; October 21-24, 2015. Vancouver, British Columbia, Canada.

Cerebellar neurodegeneration in the absence of microRNAs

PubMed Central

Schaefer, Anne; O'Carroll, Dónal; Tan, Chan Lek; Hillman, Dean; Sugimori, Mutsuyuki; Llinas, Rodolfo; Greengard, Paul

2007-01-01

Genome-encoded microRNAs (miRNAs) are potent regulators of gene expression. The significance of miRNAs in various biological processes has been suggested by studies showing an important role of these small RNAs in regulation of cell differentiation. However, the role of miRNAs in regulation of differentiated cell physiology is not well established. Mature neurons express a large number of distinct miRNAs, but the role of miRNAs in postmitotic neurons has not been examined. Here, we provide evidence for an essential role of miRNAs in survival of differentiated neurons. We show that conditional Purkinje cell–specific ablation of the key miRNA-generating enzyme Dicer leads to Purkinje cell death. Deficiency in Dicer is associated with progressive loss of miRNAs, followed by cerebellar degeneration and development of ataxia. The progressive neurodegeneration in the absence of Dicer raises the possibility of an involvement of miRNAs in neurodegenerative disorders. PMID:17606634

Key Facts about Higher Education in Washington. 2012

ERIC Educational Resources Information Center

Washington Higher Education Coordinating Board, 2012

2012-01-01

"Key Facts about Higher Education in Washington" provides vital data to chart higher education's progress and challenges. First published in 2002 by the Washington Higher Education Coordinating Board, this annual report highlights "Key Facts" about Washington's postsecondary institutions--including faculty, students, budgets,…

EVALUATING ANNUAL NITROUS OXIDE FLUXES AT THE ECOSYSTEM SCALE. (R824993)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

78 FR 17223 - Notice of Submission of Proposed Information Collection to OMB: Annual Progress Report (APR) for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-20

... homeless clients and service needs at the local level. HUD also uses this information to provide... information assists HUD in understanding homeless clients and service needs at the local level. HUD also uses...

Materials and Molecular Research Division annual report 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Searcy, A.W.; Muller, R.H.; Peterson, C.V.

1984-07-01

Progress is reported in the following fields: materials sciences (metallurgy and ceramics, solid-state physics, materials chemistry), chemical sciences (fundamental interactions, processes and techniques), actinide chemistry, fossil energy, electrochemical energy storage systems, superconducting magnets, semiconductor materials and devices, and work for others. (DLC)

No Child Left Behind.

ERIC Educational Resources Information Center

Bush, George W.

This blueprint describes President Bush's education plan. Federal block grants are provided to states for schools that establish annual assessments, demand progress, improve poorly-performing schools, create consequences for failure, and protect home and private schools. The "Reading First" initiative gives funds and tools to promote…

Genomics of Tropical Fruit Tree Crops

USDA-ARS?s Scientific Manuscript database

The genetic improvement of tropical fruit trees is limited when compared to progress achieved in temperate fruit trees and annual crops. Tropical fruit tree breeding programs require significant resources to develop new cultivars that are adapted to modern shipping and storage requirements. The use...

75 FR 26218 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... Mississippi, Inc submits executed Rate Schedule providing for cost-based power sales for partial requirements...: Florida Power Corporation. Description: Progress Energy Florida, Inc submits its annual cost factor... Friday, May 21, 2010. Docket Numbers: ER10-720-001. Applicants: Northeastern Power Company. Description...

Nuclear Physics Laboratory 1979 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adelberger, E.G.

1979-07-01

Research progress is reported in the following areas: astrophysics and cosmology, fundamental symmetries, nuclear structure, radiative capture, medium energy physics, heavy ion reactions, research by users and visitors, accelerator and ion source development, instrumentation and experimental techniques, and computers and computing. Publications are listed. (WHK)

Annual Evaluation Report 1980-1981.

ERIC Educational Resources Information Center

Boynton, Mary

The report reviews the Colorado Migrant Education Resource Center's (CoMERC's) progress from September 1980 through September 1981 in accomplishing the following goals: conducting needs assessment for training and for migrant education materials; providing training and technical and programatic assistance to local education agencies (LEA's);…

Laser program. Annual report, 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monsler, M.J.; Jarman, B.D.

1979-03-01

This volume documents progress in advanced quantum electronics - primarily the quest for advanced rep-rateable short-wavelength lasers with high efficiency. Application studies in electrical energy production and fissile fuel production are also described. Selected highlights of the advanced isotope separation program are also presented. (MOW)

Annual Review of Sociology. Volume 9, 1983.

ERIC Educational Resources Information Center

Turner, Ralph H., Ed.; Short, James F., Jr., Ed.

Twenty-six essays describing current research in sociology are included in this publication. The essays fall into 10 categories: differentiation and stratification; political sociology; social processes; institutions; individual and society; formal organizations; urban sociology; theory and methods; sociology of world regions; and historical…

40 CFR 98.3 - What are the general monitoring, reporting, recordkeeping and verification requirements of this...

Code of Federal Regulations, 2012 CFR

2012-07-01

... (c)(12)(iii) of this section. If the latter reporting option is chosen, you must report: (i) Annual... flow meter's primary element (e.g., the orifice plate), or when there is only a differential pressure...

Association Between Breast Cancer Disease Progression and Workplace Productivity in the United States.

PubMed

Yin, Wesley; Horblyuk, Ruslan; Perkins, Julia Jane; Sison, Steve; Smith, Greg; Snider, Julia Thornton; Wu, Yanyu; Philipson, Tomas J

2017-02-01

Determine workplace productivity losses attributable to breast cancer progression. Longitudinal analysis linking 2005 to 2012 medical and pharmacy claims and workplace absence data in the US patients were commercially insured women aged 18 to 64 diagnosed with breast cancer. Productivity was measured as employment status and total quarterly workplace hours missed, and valued using average US wages. Six thousand four hundred and nine women were included. Breast cancer progression was associated with a lower probability of employment (hazard ratio [HR] = 0.65, P < 0.01) and increased workplace hours missed. The annual value of missed work was $24,166 for non-metastatic and $30,666 for metastatic patients. Thus, progression to metastatic disease is associated with an additional $6500 in lost work time (P < 0.05), or 14% of average US wages. Breast cancer progression leads to diminished likelihood of employment, increased workplace hours missed, and increased cost burden.

Seasonal emanation of radon at Ghuttu, northwest Himalaya: Differentiation of atmospheric temperature and pressure influences.

PubMed

Kamra, Leena

2015-11-01

Continuous monitoring of radon along with meteorological parameters has been carried out in a seismically active area of Garhwal region, northwest Himalaya, within the frame work of earthquake precursory research. Radon measurements are carried out by using a gamma ray detector installed in the air column at a depth of 10m in a 68m deep borehole. The analysis of long time series for 2006-2012 shows strong seasonal variability masked by diurnal and multi-day variations. Isolation of a seasonal cycle by minimising short-time by 31 day running average shows a strong seasonal variation with unambiguous dependence on atmospheric temperature and pressure. The seasonal characteristics of radon concentrations are positively correlated to atmospheric temperature (R=0.95) and negatively correlated to atmospheric pressure (R=-0.82). The temperature and pressure variation in their annual progressions are negatively correlated. The calculations of partial correlation coefficient permit us to conclude that atmospheric temperature plays a dominant role in controlling the variability of radon in borehole, 71% of the variability in radon arises from the variation in atmospheric temperature and about 6% of the variability is contributed by atmospheric pressure. The influence of pressure variations in an annual cycle appears to be a pseudo-effect, resulting from the negative correlation between temperature and pressure variations. Incorporation of these results explains the varying and even contradictory claims regarding the influence of the pressure variability on radon changes in the published literature. Temperature dependence, facilitated by the temperature gradient in the borehole, controls the transportation of radon from the deep interior to the surface. Copyright © 2015 Elsevier Ltd. All rights reserved.

Child Mortality Estimation: Accelerated Progress in Reducing Global Child Mortality, 1990–2010

PubMed Central

Hill, Kenneth; You, Danzhen; Inoue, Mie; Oestergaard, Mikkel Z.; Hill, Kenneth; Alkema, Leontine; Cousens, Simon; Croft, Trevor; Guillot, Michel; Pedersen, Jon; Walker, Neff; Wilmoth, John; Jones, Gareth

2012-01-01

Monitoring development indicators has become a central interest of international agencies and countries for tracking progress towards the Millennium Development Goals. In this review, which also provides an introduction to a collection of articles, we describe the methodology used by the United Nations Inter-agency Group for Child Mortality Estimation to track country-specific changes in the key indicator for Millennium Development Goal 4 (MDG 4), the decline of the under-five mortality rate (the probability of dying between birth and age five, also denoted in the literature as U5MR and 5 q 0). We review how relevant data from civil registration, sample registration, population censuses, and household surveys are compiled and assessed for United Nations member states, and how time series regression models are fitted to all points of acceptable quality to establish the trends in U5MR from which infant and neonatal mortality rates are generally derived. The application of this methodology indicates that, between 1990 and 2010, the global U5MR fell from 88 to 57 deaths per 1,000 live births, and the annual number of under-five deaths fell from 12.0 to 7.6 million. Although the annual rate of reduction in the U5MR accelerated from 1.9% for the period 1990–2000 to 2.5% for the period 2000–2010, it remains well below the 4.4% annual rate of reduction required to achieve the MDG 4 goal of a two-thirds reduction in U5MR from its 1990 value by 2015. Thus, despite progress in reducing child mortality worldwide, and an encouraging increase in the pace of decline over the last two decades, MDG 4 will not be met without greatly increasing efforts to reduce child deaths. PMID:22952441

Audiometric analyses confirm a cochlear component, disproportional to age, in stapedial otosclerosis.

PubMed

Topsakal, Vedat; Fransen, Erik; Schmerber, Sébastien; Declau, Frank; Yung, Matthew; Gordts, Frans; Van Camp, Guy; Van de Heyning, Paul

2006-09-01

To report the preoperative audiometric profile of surgically confirmed otosclerosis. Retrospective, multicenter study. Four tertiary referral centers. One thousand sixty-four surgically confirmed patients with otosclerosis. Therapeutic ear surgery for hearing improvement. Preoperative audiometric air conduction (AC) and bone conduction (BC) hearing thresholds were obtained retrospectively for 1064 patients with otosclerosis. A cross-sectional multiple linear regression analysis was performed on audiometric data of affected ears. Influences of age and sex were analyzed and age-related typical audiograms were created. Bone conduction thresholds were corrected for Carhart effect and presbyacusis; in addition, we tested to see if separate cochlear otosclerosis component existed. Corrected thresholds were than analyzed separately for progression of cochlear otosclerosis. The study population consisted of 35% men and 65% women (mean age, 44 yr). The mean pure-tone average at 0.5, 1, and 2 kHz was 57 dB hearing level. Multiple linear regression analysis showed significant progression for all measured AC and BC thresholds. The average annual threshold deterioration for AC was 0.45 dB/yr and the annual threshold deterioration for BC was 0.37 dB/yr. The average annual gap expansion was 0.08 dB/year. The corrected BC thresholds for Carhart effect and presbyacusis remained significantly different from zero, but only showed progression at 2 kHz. The preoperative audiological profile of otosclerosis is described. There is a significant sensorineural component in patients with otosclerosis planned for stapedotomy, which is worse than age-related hearing loss by itself. Deterioration rates of AC and BC thresholds have been reported, which can be helpful in clinical practice and might also guide the characterization of allegedly different phenotypes for familial and sporadic otosclerosis.

The Impact of Task Difficulty and Performance Scores on Student Engagement and Progression

ERIC Educational Resources Information Center

Lynch, Raymond; Patten, James Vincent; Hennessy, Jennifer

2013-01-01

Background: This article considers the impact of differential task difficulty on student engagement and progression within an Irish primary school context. Gaining and maintaining student engagement during learning tasks such as homework is a significant and understandable on-going challenge for teachers. The findings of this study hold the…

A Safe and Welcoming Place?: Workplace Progression for Women Staff.

ERIC Educational Resources Information Center

Gardiner, Jean; O'Rourke, Rebecca

1995-01-01

Interviews with seven women lecturers and five administrative/library staff at Leeds University uncovered the following: differential career paths for women and men; a link between the extent of career progression and working full or part time; and few opportunities for gender issues to be openly discussed in the academic workplace. (SK)

Sex Differential Item Functioning in the Inventory of Early Development III Social-Emotional Skills

ERIC Educational Resources Information Center

Beaver, Jessica L.; French, Brian F.; Finch, W. Holmes; Ullrich-French, Sarah C.

2014-01-01

Social-emotional (SE) skills in the early developmental years of children influence outcomes in psychological, behavioral, and learning domains. The adult ratings of a child's SE skills can be influenced by sex stereotypes. These rating differences could lead to differential conclusions about developmental progress or risk. To ensure that…

Differentiation and specialization in the California hospital industry 1983 to 1988.

PubMed

Zwanziger, J; Melnick, G A; Simonson, L

1996-04-01

This article examines changes in the service mix of California hospitals as part of their response to shifts in the system of reimbursement between 1983 and 1988. The Hospital Discharge Data Set and the Annual Hospital Disclosure Report produced by California Office of Statewide Health Planning and Development were used in this study. Characteristics of inpatient hospital services in California before and after the introduction of new reimbursement mechanisms (including the Medicare Prospective Payment System [PPS] and the growth of selective contracting plans) were compared. The factors that influence two measures of hospital service mix, one focusing on specialization and the other on differentiation, were studied. The factors included hospital characteristics and changes in hospital reimbursement. Variables describing a hospital's service mix and the level in its market were constructed from data in the annual discharge abstracts. Data pertaining to average hospital costs and reimbursements under the Medicare PPS were drawn from a file containing a 20% sample of hospital stay records for the year of PPS. Other hospital data, such as ownership and bed size, were taken from the California Annual Disclosure Report data set. The results indicate that completion among hospitals tended to increase differentiation whereas higher financial PPS pressure is associated with increased specialization. Hospitals tend to adopt some high visibility services offered by their competitors while filling market niches selectively overall. It also appears that the cost savings expected for specialization may prevail only for narrowly defined services. Study of subsequent data sets should show whether the cost containment strategies used by the hospitals to achieve these results have been maintained over a period of sustained financial pressure.

The genetic network controlling plasma cell differentiation.

PubMed

Nutt, Stephen L; Taubenheim, Nadine; Hasbold, Jhagvaral; Corcoran, Lynn M; Hodgkin, Philip D

2011-10-01

Upon activation by antigen, mature B cells undergo immunoglobulin class switch recombination and differentiate into antibody-secreting plasma cells, the endpoint of the B cell developmental lineage. Careful quantitation of these processes, which are stochastic, independent and strongly linked to the division history of the cell, has revealed that populations of B cells behave in a highly predictable manner. Considerable progress has also been made in the last few years in understanding the gene regulatory network that controls the B cell to plasma cell transition. The mutually exclusive transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors, those that maintain the B cell program, including Pax5, Bach2 and Bcl6, and those that promote and facilitate plasma cell differentiation, notably Irf4, Blimp1 and Xbp1. In this review, we discuss progress in the definition of both the transcriptional and cellular events occurring during late B cell differentiation, as integrating these two approaches is crucial to defining a regulatory network that faithfully reflects the stochastic features and complexity of the humoral immune response. 2011 Elsevier Ltd. All rights reserved.

Prospects for detection of target-dependent annual modulation in direct dark matter searches

DOE PAGES

Nobile, Eugenio Del; Gelmini, Graciela B.; Witte, Samuel J.

2016-02-03

Earth's rotation about the Sun produces an annual modulation in the expected scattering rate at direct dark matter detection experiments. The annual modulation as a function of the recoil energy E R imparted by the dark matter particle to a target nucleus is expected to vary depending on the detector material. However, for most interactions a change of variables from E R to v min, the minimum speed a dark matter particle must have to impart a fixed E R to a target nucleus, produces an annual modulation independent of the target element. We recently showed that if the darkmore » matter-nucleus cross section contains a non-factorizable target and dark matter velocity dependence, the annual modulation as a function of v min can be target dependent. Here we examine more extensively the necessary conditions for target-dependent modulation, its observability in present-day experiments, and the extent to which putative signals could identify a dark matter-nucleus differential cross section with a non-factorizable dependence on the dark matter velocity.« less

Serum Bilirubin and Disease Progression in Mild COPD

PubMed Central

Apperley, Scott; Park, Hye Yun; Holmes, Daniel T.; Wise, Robert A.; Connett, John E.

2015-01-01

BACKGROUND: COPD is a chronic inflammatory disorder associated with oxidative stress. Serum bilirubin has potent antioxidant actions, and higher concentrations have been shown to protect against oxidative stress. The relation between serum bilirubin and COPD progression is unknown. METHODS: Serum bilirubin was measured in 4,680 smokers aged 35 to 60 years old with mild to moderate airflow limitation. The relationship of serum bilirubin to postbronchodilator FEV1 and rate of FEV1 decline over 3 to 9 years was determined using regression modeling. Total and disease-specific mortality were also ascertained. RESULTS: Serum bilirubin was positively related to FEV1 (P < .001). Serum bilirubin was also negatively related to the annual decline in FEV1 when adjusted for baseline demographics, pack-years smoked, and baseline measures of lung function (P = .01). Additionally, serum bilirubin was negatively associated with risk of death from coronary heart disease (P = .03); however, the relationships between bilirubin and other mortality end points were not statistically significant (P > .05). CONCLUSIONS: Bilirubin is inversely related to COPD disease severity and progression. Higher serum bilirubin concentration was associated with a higher FEV1 and less annual decline in FEV1. Bilirubin was also associated with less coronary heart disease mortality. These data support the hypothesis that bilirubin has a protective effect on COPD disease progression, possibly through its antioxidant actions. Bilirubin may prove useful as an easily accessible and readily available blood-based COPD biomarker. PMID:25539285

Paralogous SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes differentially regulate leaf initiation and reproductive phase change in petunia.

PubMed

Preston, Jill C; Jorgensen, Stacy A; Orozco, Rebecca; Hileman, Lena C

2016-02-01

Duplicated petunia clade-VI SPL genes differentially promote the timing of inflorescence and flower development, and leaf initiation rate. The timing of plant reproduction relative to favorable environmental conditions is a critical component of plant fitness, and is often associated with variation in plant architecture and habit. Recent studies have shown that overexpression of the microRNA miR156 in distantly related annual species results in plants with perennial characteristics, including late flowering, weak apical dominance, and abundant leaf production. These phenotypes are largely mediated through the negative regulation of a subset of genes belonging to the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) family of transcription factors. In order to determine how and to what extent paralogous SPL genes have partitioned their roles in plant growth and development, we functionally characterized petunia clade-VI SPL genes under different environmental conditions. Our results demonstrate that PhSBP1and PhSBP2 differentially promote discrete stages of the reproductive transition, and that PhSBP1, and possibly PhCNR, accelerates leaf initiation rate. In contrast to the closest homologs in annual Arabidopsis thaliana and Mimulus guttatus, PhSBP1 and PhSBP2 transcription is not mediated by the gibberellic acid pathway, but is positively correlated with photoperiod and developmental age. The developmental functions of clade-VI SPL genes have, thus, evolved following both gene duplication and speciation within the core eudicots, likely through differential regulation and incomplete sub-functionalization.

Quarterly Progress Report (January 1 to March 31, 1950)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brookhaven National Laboratory

This is the first of a series of Quarterly Reports. These reports will deal primarily with the progress made in our scientific program during a three months period. Those interested in matters pertaining to organization, administration, complete scientific program, personnel and other matters not directly involved in current scientific progress are referred to our Annual Progress Report which is issued in January. We have attempted to describe new information that appears significant, or of interest, to other scientists within the Atomic Energy Commission Laboratories. No effort has been made, however, to detail progress in each and every research project. Littlemore » or no reference will therefore be found to the projects in which progress during the current period is considered too inconclusive. Since our organizational structure is departmental, the work described herein is arranged in the following sequence: (1) Accelerator Project; (2) Biology Department; (3) Chemistry Department; (4) Instrumentation and Health Physic8 Department; (5) Medical Department; (6) Physics Department; and (7) Reactor Science and Engineering Department.« less

Overlapping DNA Methylation Dynamics in Mouse Intestinal Cell Differentiation and Early Stages of Malignant Progression

PubMed Central

Forn, Marta; Díez-Villanueva, Anna; Merlos-Suárez, Anna; Muñoz, Mar; Lois, Sergi; Carriò, Elvira; Jordà, Mireia; Bigas, Anna; Batlle, Eduard; Peinado, Miguel A.

2015-01-01

Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. To get insights into the dynamics of cell differentiation and malignant transformation we have compared the DNA methylation profiles along the mouse small intestine crypt and early stages of tumorigenesis. Genome-scale analysis of DNA methylation together with microarray gene expression have been applied to compare intestinal crypt stem cells (EphB2high), differentiated cells (EphB2negative), ApcMin/+ adenomas and the corresponding non-tumor adjacent tissue, together with small and large intestine samples and the colon cancer cell line CT26. Compared with late stages, small intestine crypt differentiation and early stages of tumorigenesis display few and relatively small changes in DNA methylation. Hypermethylated loci are largely shared by the two processes and affect the proximities of promoter and enhancer regions, with enrichment in genes associated with the intestinal stem cell signature and the PRC2 complex. The hypermethylation is progressive, with minute levels in differentiated cells, as compared with intestinal stem cells, and reaching full methylation in advanced stages. Hypomethylation shows different signatures in differentiation and cancer and is already present in the non-tumor tissue adjacent to the adenomas in ApcMin/+ mice, but at lower levels than advanced cancers. This study provides a reference framework to decipher the mechanisms driving mouse intestinal tumorigenesis and also the human counterpart. PMID:25933092

ROCK CREEK, IDAHO RURAL CLEAN WATER PROGRAM, 1987 ANNUAL PROGRESS REPORT

EPA Science Inventory

Goals of the Rock Creek, Idaho (17040212) Rural Clean Water Program are to significantly reduce the amount of sediment, sediment related pollutants, and animal waste discharging into Rock Creek. Weekly water quality sampling was done through the irrigation season (April - Octobe...

76 FR 1471 - FY 2010 Annual Compliance Report; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-10

... issued rules on periodic reporting of service performance measurement and customer satisfaction in FY...-FY10- 29. Id. at 12. Customer satisfaction. The FY 2010 ACR discusses the Postal Service's transition... filing; service performance results; levels of customer satisfaction achieved; progress toward goals...

2010/2015 PFOA Stewardship Program - 2014 Annual Progress Reports

EPA Pesticide Factsheets

In 2006, EPA and the eight major companies in the industry launched the 2010/15 PFOA Stewardship Program, in which companies committed to reduce global facility emissions and product content of PFOA and related chemicals by 95 percent by 2010, and to work

Skills Verdict: Must Do Better

ERIC Educational Resources Information Center

Spilsbury, Mark

2010-01-01

"Ambition 2020: World Class Skills and Jobs" is the UK Commission for Employment and Skills' annual assessment, to the four UK nations, of their progress towards becoming "world class" in productivity, employment and skills by 2020. "Ambition 2020" provides a robust independent account of economic and skills…

Pacific Northwest Laboratory annual report for 1980 to the DOE Assistant Secretary for Environment. Part 1. Biomedical sciences. [Lead abstract

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drucker, H.

1981-02-01

Separate abstracts were prepared for 31 sections in this progress report. The appendix which deals with dose-effect studies with inhaled plutonium in beagles is not represented by a separate abstract. (KRM)

INTRA-ANNUAL AND INTERANNUAL VARIABILITY OF ECOSYSTEM PROCESSES IN SHORTGRASS STEPPE. (R824993)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Annual Progress Report FY-82. Volume I.

DTIC Science & Technology

1982-01-01

Comparison of Binaural Versus 316 Monaural Amplification. (FY-81PI) 2535 Development of Method for Generating 318 Individualized Aural Rehabilitation...Oncology Group. 428 (FY-74 I ) 4116 The Evaluation of Petal Systolic Time Intervals 429 and Beat interval Variation in Fetal heart Rate as Early