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Sample records for digboiensis teri asn6

  1. Isolation of a novel yeast strain Candida digboiensis TERI ASN6 capable of degrading petroleum hydrocarbons in acidic conditions.

    PubMed

    Sood, Nitu; Lal, Banwari

    2009-04-01

    A novel yeast species Candida digboiensis TERI ASN6 was isolated from soil samples contaminated with acidic oily sludge (pH 1-3) from the Digboi refinery (Northeast India). The strain TERI ASN6 could degrade 73% of the total petroleum hydrocarbons present in the medium at pH 3 in a week. This strain presents a dimorphic behaviour and showed mycelia morphology when grown under stressed conditions such as low pH and in a medium containing petroleum hydrocarbons. The C. digboiensis strain could efficiently degrade the aliphatic and aromatic fractions of the acidic oily sludge at pH 3 as confirmed by gas chromatography. During the growth of TERI ASN6 in dibenzothiophene (DBT), DBT-sulfone and biphenyl-2-ol were detected. An active cytochrome P450 system, implicated in hydrocarbon oxidation, was also detected in this yeast using degenerated primers based on its conserved regions. This yeast is a potential candidate for petroleum bioremediation treatment of hydrocarbon contaminated acidic soils. Its physiological behaviour allows the strain to work efficiently where other hydrocarbon-degrading bacteria may not survive.

  2. Bioremediation of acidic oily sludge-contaminated soil by the novel yeast strain Candida digboiensis TERI ASN6.

    PubMed

    Sood, Nitu; Patle, Sonali; Lal, Banwari

    2010-03-01

    Primitive wax refining techniques had resulted in almost 50,000 tonnes of acidic oily sludge (pH 1-3) being accumulated inside the Digboi refinery premises in Assam state, northeast India. A novel yeast species Candida digboiensis TERI ASN6 was obtained that could degrade the acidic petroleum hydrocarbons at pH 3 under laboratory conditions. The aim of this study was to evaluate the degradation potential of this strain under laboratory and field conditions. The ability of TERI ASN6 to degrade the hydrocarbons found in the acidic oily sludge was established by gravimetry and gas chromatography-mass spectroscopy. Following this, a feasibility study was done, on site, to study various treatments for the remediation of the acidic sludge. Among the treatments, the application of C. digboiensis TERI ASN6 with nutrients showed the highest degradation of the acidic oily sludge. This treatment was then selected for the full-scale bioremediation study conducted on site, inside the refinery premises. The novel yeast strain TERI ASN6 could degrade 40 mg of eicosane in 50 ml of minimal salts medium in 10 days and 72% of heneicosane in 192 h at pH 3. The degradation of alkanes yielded monocarboxylic acid intermediates while the polycyclic aromatic hydrocarbon pyrene found in the acidic oily sludge yielded the oxygenated intermediate pyrenol. In the feasibility study, the application of TERI ASN6 with nutrients showed a reduction of solvent extractable total petroleum hydrocarbon (TPH) from 160 to 28.81 g kg(-1) soil as compared to a TPH reduction from 183.85 to 151.10 g kg(-1) soil in the untreated control in 135 days. The full-scale bioremediation study in a 3,280-m(2) area in the refinery showed a reduction of TPH from 184.06 to 7.96 g kg(-1) soil in 175 days. Degradation of petroleum hydrocarbons by microbes is a well-known phenomenon, but most microbes are unable to withstand the low pH conditions found in Digboi refinery. The strain C. digboiensis could efficiently degrade

  3. Electronic Library: A TERI Experiment.

    ERIC Educational Resources Information Center

    Kar, Debal C.; Deb, Subrata; Kumar, Satish

    2003-01-01

    Discusses the development of Electronic Library at TERI (The Energy and Resources Institute, New Delhi). Highlights include: hardware and software used; the digital library/Virtual Electronic Library; directory of Internet journals; virtual reference resources; electronic collection/Physical Electronic Library; downloaded online full-length…

  4. Electronic Library: A TERI Experiment.

    ERIC Educational Resources Information Center

    Kar, Debal C.; Deb, Subrata; Kumar, Satish

    2003-01-01

    Discusses the development of Electronic Library at TERI (The Energy and Resources Institute, New Delhi). Highlights include: hardware and software used; the digital library/Virtual Electronic Library; directory of Internet journals; virtual reference resources; electronic collection/Physical Electronic Library; downloaded online full-length…

  5. Isolation and identification of a Candida digboiensis strain from an extreme acid mine drainage of the Lignite Mine, Gujarat.

    PubMed

    Patel, Mitesh J; Tipre, Devayani R; Dave, Shailesh R

    2009-12-01

    An extremely acidic mine drainage (AMD) water sample was collected in 1998 and 2008 from Panandhro lignite mine, Gujarat, India. The yeast isolated from this sample was identified using mini API identification system, as a member of genus Candida. The major cellular fatty acids detected by FAME from the isolate are C(16:0) and C(18:2) (cis 9,12)/C(18:0alpha) as 25.23 and 19.5%, respectively. The isolate was identified as Candida digboiensis by 18S rRNA gene sequence analysis and designated as Candida digboiensis SRDyeast1. Phylogenetic analysis using D1/D2 variable domains showed that the closest relative of this strain is Candida blankii with 3% divergence. This organism has been reported for the first time from the lignite mine AMD sample, and for cellular fatty acid analysis. This yeast is able to survive in the AMD sample preserved at 10-42 degrees C temperature since last 10 years along with iron oxidizing microorganisms. It can grow in the presence of 40% glucose, 10% NaCl and in the pH range of 1 to 10. The isolate is capable of producing enzymes like protease and lipase. This isolate differs from the type strain Candida digboiensis in as many as six physiological and metabolic characteristics.

  6. Isolation and characterization of a potential paraffin-wax degrading thermophilic bacterial strain Geobacillus kaustophilus TERI NSM for application in oil wells with paraffin deposition problems.

    PubMed

    Sood, Nitu; Lal, Banwari

    2008-02-01

    Paraffin deposition problems, that have plagued the oil industry, are currently remediated by mechanical and chemical means. However, since these methods are problematic, a microbiological approach has been considered. The bacteria, required for the mitigation of paraffin deposition problems, should be able to survive the high temperatures of oil wells and degrade the paraffins under low oxygen and nutrient conditions while sparing the low carbon chain paraffins. In this study, a thermophilic paraffinic wax degrading bacterial strain was isolated from a soil sample contaminated with paraffinic crude oil. The selected strain, Geobacillus TERI NSM, could degrade 600mg of paraffinic wax as the sole carbon source in 1000ml minimal salts medium in 7d at 55 degrees C. This strain was identified as Geobacillus kaustophilus by fatty acid methyl esters analysis and 16S rRNA full gene sequencing. G. kaustophilus TERI NSM showed 97% degradation of eicosane, 85% degradation of pentacosane and 77% degradation of triacontane in 10d when used as the carbon source. The strain TERI NSM could also degrade the paraffins of crude oil collected from oil wells that had a history of paraffin deposition problems.

  7. Bioflocculant production and biosorption of zinc and lead by a novel bacterial species, Achromobacter sp. TERI-IASST N, isolated from oil refinery waste.

    PubMed

    Subudhi, Sanjukta; Batta, Neha; Pathak, Mihirjyoti; Bisht, Varsha; Devi, Arundhuti; Lal, Banwari; Al khulifah, Bader

    2014-10-01

    A bioflocculant-producing bacterial isolate designated as 'TERI-IASST N' was isolated from activated sludge samples collected from an oil refinery. This isolate demonstrated maximum bioflocculation activity (74%) from glucose among 15 different bioflocculant-producing bacterial strains isolated from the sludge samples and identified as Achromobacter sp. based on 16S rRNA gene sequence. Optimization of pH and supplementation of urea as nitrogen source in the production medium enhanced the flocculation activity of strain TERI-IASST N to 84% (at pH 6). This strain revealed maximum flocculation activity (90%) from sucrose compared to the flocculation activity observed from other carbon sources as investigated (glucose, lactose, fructose, maltose and starch). Ca(2+) served as the suitable divalent cation for maximum bioflocculation activity of TERI-IASST strain N. Maximum flocculation activity was observed at optimum C/N ratio of 1. Flocculation activity of this strain decreased to 75% in the presence of heavy metals; Zn, Pb, Ni, Cu and Cd. In addition strain N revealed considerable biosorption of Zn (430mgL(-1)) and Pb (30mgL(-1)). Bioflocculant yield of strain N was 10.5gL(-1). Fourier transform infrared spectrum indicated the presence of carboxyl, hydroxyl, and amino groups, typical of glycoprotein. Spectroscopic analysis of bioflocculant by nuclear magnetic resonance revealed that it is a glycoprotein, consisting of 57% total sugar and 13% protein.

  8. Environmental Management Systems for Educational Institutions: A Case Study of Teri University, New Delhi

    ERIC Educational Resources Information Center

    Jain, Suresh; Pant, Pallavi

    2010-01-01

    Purpose: The purpose of this paper is to put forth a model for implementation of an environmental management system (EMS) in institutes of higher education in India. Design/methodology/approach: The authors carried out initial environmental review (IER) and strengths, weaknesses, opportunities and threats (SWOT) analysis to identify the major…

  9. Debunking the Myth-tery: How the New AASL Standards Unplugged Mythology

    ERIC Educational Resources Information Center

    Hubbard, Erin E.

    2009-01-01

    Though few students realize it, many things in today's culture exist because of mythology. This article argues that library media specialists and teachers can teach mythology but it must be applied to the 21st century and shown its relevance in today's world. The article demonstrates that mythology studies are alive and well when the new AASL…

  10. Environmental Management Systems for Educational Institutions: A Case Study of Teri University, New Delhi

    ERIC Educational Resources Information Center

    Jain, Suresh; Pant, Pallavi

    2010-01-01

    Purpose: The purpose of this paper is to put forth a model for implementation of an environmental management system (EMS) in institutes of higher education in India. Design/methodology/approach: The authors carried out initial environmental review (IER) and strengths, weaknesses, opportunities and threats (SWOT) analysis to identify the major…

  11. Functional efficacy of human recombinant FGF-2s tagged with (His)6 and (His-Asn)6 at the N- and C-termini in human gingival fibroblast and periodontal ligament-derived cells.

    PubMed

    Lee, Ji-Hye; Lee, Ji-Eun; Kang, Kyung-Jung; Jang, Young-Joo

    2017-07-01

    Fibroblast growth factor (FGF) is a multifunctional growth factor that induces cell proliferation, survival, migration, and differentiation in various cell types and tissues. With these biological functions, FGF-2 has been evaluated for clinical use in the regeneration of damaged tissues. The expression of hFGF-2 in Escherichia coli and a purification system using the immobilized metal affinity chromatography (IMAC) is well established to generate a continuous supply of FGF-2. Although hexa-histidine tag (H6) is commonly used for IMAC purification, hexa-histidine-asparagine tag (HN6) is also efficient for purification as it is easily exposed on the surface of the protein. In this study, four different tagging constructs of hFGF-2 based on tag positions and types (H6-FGF2, FGF2-H6, HN6-FGF2, and FGF2-HN6) were designed and expressed under the inducible T7 expression system in E. coli. The experimental conditions of expression and purification of each recombinant protein were optimized. The effective dosages of the recombinant proteins were determined based on the increase of cell proliferation in human gingival fibroblast. ED50s of H6-FGF2, FGF2-H6, HN6-FGF2, and FGF2-HN6 were determined (4.42 ng/ml, 3.55 ng/ml, 3.54 ng/ml, and 4.14 ng/ml, respectively) and found to be comparable to commercial FGF-2 (3.67 ng/ml). All the recombinant hFGF-2s inhibit the osteogenic induction and mineralization in human periodontal ligament-derived cells. Our data suggested that biological activities of the recombinant hFGF-2 are irrelevant to types and positions of tags, but may have an influence on the expression efficiency and solubility. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Tailoring Configuration to User’s Tasks under Uncertainty

    DTIC Science & Technology

    2008-04-28

    predicting the available level of resources such as network bandwidth, bat- tery energy, and CPU cycles. As the Jane example demonstrated, such...characterized the bat- tery drain due to various hardware components in different modes. For example, Flinn’s ap- proach measures the power consumption of...Example 4: A typical laptop computer has several scheduled background tasks (backup, virus scan, spy-ware check, other self-diagnostic activity) that

  13. Mechanisms of Exhaust Pollutants and Plume Formation in Continuous Combustion.

    DTIC Science & Technology

    1984-06-01

    IN CONTINUOUS COMBUSTION E AFOSR 78-3586 G.S. Samuelsen UCI -ARTR-84-7 ci~LAi June 1984 Ř Mechanical Engineering Univgrsity of California Irvine...ORGANIZATION ’b- OFFICE SYMBOL 74. NAME OF MONITORING ORGANIZATION University of California I IfiapphuabielArFreOfi fSintfcRsac UCI Combustion ...SUPPLEMENTARY NOTATION 17 COSATI CODES iI19. SUBJaECT TERI,.S (Continue on pWar~tlee~r aid ida ify by blocir nurnbar, ’efLO TGROUP I sue. R ’ Combustion and

  14. How Much Do We Know about the Most Common Medicines Used during Pregnancy?

    MedlinePlus

    ... common medicines used during this time, they examined what is known about these medicines. They looked up each medicine in a database called TERIS, which contains information about medicine exposures during ... looked at what was known about each medicine’s risk of causing ...

  15. A Survey of the Use of Ceramics in Battery and Fuel Cell Applications

    DTIC Science & Technology

    1977-06-01

    Batteries Which Operate at Near Ambient Temperature 8 Lithium - Thionyl Chloride Batteries 8 Lithium -Vanadium Pentoxide... Lithium - Thionyl Chloride Bat teries Lithium - thionyl chloride cells and batteries have become available in reasonable quantities during the...Continued) Page Lithium -Metal Sulfide Batteries 27 Lithium -Metal Chloride Batteries 30 Lithium

  16. From Numbers to Letters: Feedback Regularization in Visual Word Recognition

    ERIC Educational Resources Information Center

    Molinaro, Nicola; Dunabeitia, Jon Andoni; Marin-Gutierrez, Alejandro; Carreiras, Manuel

    2010-01-01

    Word reading in alphabetic languages involves letter identification, independently of the format in which these letters are written. This process of letter "regularization" is sensitive to word context, leading to the recognition of a word even when numbers that resemble letters are inserted among other real letters (e.g., M4TERI4L). The present…

  17. Parallel Logic Programming and ZMOB and Parallel Systems Software and Hardware.

    DTIC Science & Technology

    1983-09-01

    The fNnetioual ipecific:tion of a hy:,tem teried PRIS M ( ParAlel Inference System) was ,’en.oiti.d coimpleted Ifore the start of the effort. A document...high level operational and axiomatic definition of the PSM. The code has -, to be debugged and requires the availability of ZMOB. (7) Communication

  18. The Transition from Inpatient to Outpatient Care.

    ERIC Educational Resources Information Center

    Berman, Alan L.; And Others

    1994-01-01

    Presents case of 29-year-old white male veteran, whose case illustrates need for coordination of inpatient and outpatient services for chronically suicidal patients to reduce risk during transition. Includes comments on case from Phillip Kleespies, Sarah Marshall, Teri Pokrajac, and Richard Amodio and from Mark Goldblatt. (NB)

  19. Defining the DOD Role in National Cybersecurity

    DTIC Science & Technology

    2013-03-01

    a new wave of cyber attacks sweeping the Middle East and North Africa region. The virus has been found in Windows 32bit systems, with the majority...DC: U.S. Department of Justice, September 2011), iv. 54 This is a fictional scenario for illustrative purposes only. 33 55 Teri M. Takai

  20. Army Communicator (Volume 37, Number 4, Winter 2012)

    DTIC Science & Technology

    2012-01-01

    address, LDIF role name, interoper- ability, compatibility, classification, anti- virus and domain status, and support chain for each asset. This...is bat- tery management. Prior to the Army’s focus on COIN and the funds that came with fighting on multiple fronts, the BN S-6 had to manage a

  1. National Training Center: Success Tips for Battalion Signal Officers

    DTIC Science & Technology

    2012-01-01

    The S-6 has to track the software version, MAC and IP address, LDIF role name, interopera- bility, compatibility, classification, anti- virus and...a generator running out of fuel. One of the lost arts of the pre-9/11 signal section is bat- tery management. Prior to the Army’s focus on COIN

  2. Cloud Computing Solutions for the Marine Corps: An Architecture to Support Expeditionary Logistics

    DTIC Science & Technology

    2013-09-01

    computing architecture will need to possess firewalls and an updated anti- virus program that can automatically detect, isolate, and/or destroy viruses ...uscn to efficicntl y occeoo ~ teri ~ readineao i nformation required to etrectlvely .anagt thtir unit’G s upply ond ~a1ntenancc reAdiness posture

  3. CHIPS. Volume 29, Issue 1, January - March 2011

    DTIC Science & Technology

    2011-03-01

    Gates named Teri Takai as the new DoD CIO. As a part of the Secretary’s ongoing efficiency efforts, the position of Assistant Secretary of Defense for...operate safely in the Web environment is everyone’s respon- sibility. Doing the basics: keeping virus scan updated, not connecting unauthor- ized

  4. Iran’s Nuclear Future: Critical U.S. Policy Choices

    DTIC Science & Technology

    2011-01-01

    suggested the transfer of two additional Patriot bat- teries each to Bahrain, Kuwait, Qatar, and the UAE.17 While the GCC states are concerned by...setbacks Iran has faced in the aftermath of the Stux- net computer virus and other sabotage efforts) may be working to at least delay the Iranian program

  5. European Science Notes. Volume 40, Number 3.

    DTIC Science & Technology

    1986-03-01

    the cold and mers. polio virus analysis with 30-fold local In addition to its use in basic re- symmetry. However, initial molecular re- search, NMR...Geom- etry for the Determination of Protein Conformation in Solution," Journal of Ma ial SciMolecular Biology, 182 (1985), teri l iences 281-294

  6. Expanding the Role of Emergency Medical Services in Homeland Security

    DTIC Science & Technology

    2013-03-01

    Medical Services FEMA Federal Emergency Management Agency FBI Federal Bureau of Investigation H1N1 Influenza a Virus HIPAA Health Information...Smyth, William G. Manley, Daniel E. Summers, Nels D. Sanddal, Teri L. Sanddal, et al. “Realities of Rural Emergency Medical Services Disaster

  7. Access to Justice: Middle School Strategies.

    ERIC Educational Resources Information Center

    Mertz, Gayle; And Others

    1989-01-01

    Gayle Mertz offers simulations covering balloting and the juvenile court system along with a legislation drafting activity. Mercedes J. Newsome provides guidance on the use of community resource persons. Teri Wilson's activity simulates a juvenile proceeding while Richard Marcroft and Elenor Taylor describe a simulation of small claims court. (KO)

  8. Advances in Distance Learning.

    ERIC Educational Resources Information Center

    1999

    This document contains three symposium papers on advances in distance learning. "The Adoption of Computer Technology and Telecommunications: A Case Study" (Larry M. Dooley, Teri Metcalf, Ann Martinez) reports on a study of the possible applications of two theoretical models (Rogers' Diffusion of Innovations model and the Concerns-Based…

  9. 76 FR 43720 - Notice of Inventory Completion: Homer Society of Natural History, Pratt Museum, Homer, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... 11, 1982, the skull was brought to the museum by Teri Dobbs. No known individual was identified. No associated funerary objects are present. The card catalog indicates that the skull was found following a...) characteristics. Based on the general appearance and condition of the skull, death occurred anywhere from 50...

  10. Quantification of Contrast Sensitivity and Color Perception using Head-worn Augmented Reality Displays

    DTIC Science & Technology

    2009-03-01

    the case the Sony Glasstron PLM -50, enables a filter that reduces transmittance of light from the environment. Two binocular displays showed differ...Edition). Thomson Wadsworth, 2007. [5] S. E. Kirkley, Jr. Augmented Reality Performance Assessment Bat- tery (ARPAB): Object Recognition, Distance

  11. Trapping systems for Zaprionus indianus (Diptera: Drosophilidae)

    USDA-ARS?s Scientific Manuscript database

    62nd Annual Meeting of the Entomological Society of America 16-19 November 2014; Portland, OR Title: Trapping systems for Zaprionus indianus (Diptera: Drosophilidae) Nancy D. Epsky, Micah A. Gill, C. Teri Allen, Dong H. Cha, and Peter J. Landolt Nancy D. Epsky USDA-ARS, Subtropical Horticulture...

  12. Getting to the next level, together. Interview by Matthew Weinstock.

    PubMed

    Fontenot, Teri

    2010-11-01

    AHA Chair-elect Teri Fontenot says hospitals, physicians, other providers, insurers and patients must work together to improve care, reduce costs and create healthier communities. The CEO of Woman's Hospital in Baton Rouge, La., shares her thoughts on health reform, leadership and other staff came together to (see text) of Hurricane Katrina.

  13. DRINKING WATER ISSUES

    EPA Science Inventory

    According to recent reports by the California Department of Health Services, the State of Maine, and the United State Geological Survey (USGS); the fuel oxygenate methyl teri-butyl ether (MTBE) is present in 5 to 20 percent of the drinking water sources in California and the nort...

  14. Internet-based information resource and discussion platform on GHG reduction strategies in Asia

    SciTech Connect

    2000-12-28

    The website (www.ccasia.teri.res.in) provides a consolidated Internet based information source and platform for discussions on climate change issues in Asia. The effort has been successful in reaching the target audience and in stimulating awareness about the crucial debate on GHG (greenhouse gas) reduction strategies in Asia.

  15. CHEMICAL ANALYSIS OF WORLD TRADE CENTER FINE PARTICULATE MATTER FOR USE IN TOXICOLOGICAL ASSESSMENT

    EPA Science Inventory

    Chemical Analysis of World Trade Center Fine Particulate Matter for Use in Toxicological Assessment
    John K. McGee1, Lung Chi Chen2, Mitchell D. Cohen2, Glen R. Chee2, Colette M. Prophete2, Najwa Haykal-Coates1, Shirley J. Wasson3, Teri L. Conner4, Daniel L. Costa1, and Steph...

  16. Access to Justice: Middle School Strategies.

    ERIC Educational Resources Information Center

    Mertz, Gayle; And Others

    1989-01-01

    Gayle Mertz offers simulations covering balloting and the juvenile court system along with a legislation drafting activity. Mercedes J. Newsome provides guidance on the use of community resource persons. Teri Wilson's activity simulates a juvenile proceeding while Richard Marcroft and Elenor Taylor describe a simulation of small claims court. (KO)

  17. CHEMICAL ANALYSIS OF WORLD TRADE CENTER FINE PARTICULATE MATTER FOR USE IN TOXICOLOGICAL ASSESSMENT

    EPA Science Inventory

    Chemical Analysis of World Trade Center Fine Particulate Matter for Use in Toxicological Assessment
    John K. McGee1, Lung Chi Chen2, Mitchell D. Cohen2, Glen R. Chee2, Colette M. Prophete2, Najwa Haykal-Coates1, Shirley J. Wasson3, Teri L. Conner4, Daniel L. Costa1, and Steph...

  18. Not Just Needlework

    ERIC Educational Resources Information Center

    Bloom, Amy Albert

    2011-01-01

    When the author's high school students explored the work of artist Teri Greeves, they accomplished several good things. They learned about a living contemporary artist and saw the potential of art as a pursuit that is pleasurable and potentially profitable. During studio work, students tried new needlework techniques to add to their toolbox of art…

  19. From Numbers to Letters: Feedback Regularization in Visual Word Recognition

    ERIC Educational Resources Information Center

    Molinaro, Nicola; Dunabeitia, Jon Andoni; Marin-Gutierrez, Alejandro; Carreiras, Manuel

    2010-01-01

    Word reading in alphabetic languages involves letter identification, independently of the format in which these letters are written. This process of letter "regularization" is sensitive to word context, leading to the recognition of a word even when numbers that resemble letters are inserted among other real letters (e.g., M4TERI4L). The present…

  20. A Young University in India Focuses on Real-World Industry and Sustainability

    ERIC Educational Resources Information Center

    Neelakantan, Shailaja

    2009-01-01

    A small, relatively new Indian university is making a name for itself--nationally and internationally--in the rapidly growing field of sustainable development. TERI University, the creation of one of India's leading environmentalists, has won praise from industry executives and academics alike. They say the institution is tackling some of the…

  1. Meta-analysis of adverse events in recent randomized clinical trials for dimethyl fumarate, glatiramer acetate and teriflunomide for the treatment of relapsing forms of multiple sclerosis.

    PubMed

    Zagmutt, Francisco J; Carroll, Cathryn A

    2015-01-01

    Trials of dimethyl fumarate (DMF) and teriflunomide, two new oral therapies for relapsing-remitting multiple sclerosis (RRMS) were recently published [1, 2, 3]. A comparison of their safety against glatiramer acetate-a prevalent injectable treatment-is relevant to inform therapy-switching decisions. The study objective was to conduct a systematic review and mixed treatment comparison of total AEs in RCTs of dimethyl fumarate 240 mg bid (DMF2) or tid (DMF3), glatiramer acetate 20 mg injectable daily (GA), and teriflunomide 7 mg (TERI7) or 14 mg (TERI14) daily in RRMS patients. Articles were selected following Cochrane guidelines. A network meta-analysis was used to compare the odds of patients experiencing at least one AE between drugs, using placebo as baseline. Drugs were compared using the odds ratio (OR), credible interval (CrI), and confidence in OR≥1 (PrOR). The mean rank (best=1) and corresponding Surface-Under-Cumulative-Ranking (SUCRA) (best=100%) were reported. 3737 patients from three RCTs were included for analysis. Patients receiving GA exhibited the lowest AEs (DMF2 [OR=2.67, PrOR=98.7%], DMF3 [OR=1.92, PrOR=95.3%], Teri7 [OR=2.74, PrOR=95.2%], Teri14 [OR=3.03, PrOR=96.4%]), and equivalent to PB (OR=1.60; PrOR=94.3%). No other significant differences were found. GA also ranked with the lowest AEs (rank=1.2, SUCRA=96.0%), whereas DMF2 and Teri14 ranked highest (rank=4.8). RRMS patients treated with glatiramer have the lowest odds of experiencing AEs, while patients taking DMF or teriflunomide have similar, higher odds of developing AEs, suggesting that patients treated with glatiramer may have higher QoL than patients under DMF or teriflunomide.

  2. Enhanced production of ligninolytic enzymes and decolorization of molasses distillery wastewater by fungi under solid state fermentation.

    PubMed

    Pant, Deepak; Adholeya, Alok

    2007-10-01

    Selected isolates of fungi were grown on wheat straw and corncob in the presence of different moistening agents such as water, molasses, potato dextrose broth and distillery effluent. All the fungal isolates responded differently with respect to growth and ligninolytic enzyme production. Fungal growth on different substrates was checked by calculating ergosterol content, which varied widely within a single species when grown on different substrates. The maximum laccase production was obtained for Aspergillus flavus TERI DB9 grown on wheat straw with molasses. For manganese peroxidase, highest production was in Aspergillus niger TERI DB20 grown on corncob with effluent. Among the two isolates positive for lignin peroxidase, the highest production was in Fusarium verticillioides ITCC 6140. This immobilized fungal biomass was then used for decolorization of effluent from a cane molasses based distillery. Maximum decolorization (86.33%) was achieved in Pleurotus ostreatus (Florida) Eger EM 1303 immobilized on corncob with molasses in a period of 28 days.

  3. Algoritmi per il calcolo dell'epatta della Luna

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2016-05-01

    On the sides of the chair of St. Hyppolitus in the Vatican Libray there is a series of 112 epacts, used for calculating the date of Christian Easter valid for 112 years from 222 AD. The algorithm of octaëteris or 8 civil (julian) years=99 lunar months and a correction of three days each 16 years or one day each 5, 5, 6 years are discussed. Four complete solar cycles (28 years), after which the sequence of the day of the week are repeating, are included in 112 years as well as 7 groups of 16 years; 112 is the minimum common multiple between the double octaëteris (16 years) and the solar cycle (28).

  4. Minilink II: Prototype of a Miniature Self-Calibrating Fiber Optic Analog Data Link

    DTIC Science & Technology

    1990-06-01

    is to be powered by bat- teries and packaged in a metal enclosure for placement in a REDEYE motor sec- tion that has been emptied of propellant . II...obsOlete UNCLASSIFIED . BLOCK 19 Abstract (Continued): for placement in a 2.5-inch ID rocket motor section that has been emptied of propellant . The...panel provides for the entrance of the signal that is being monitored via an SMA coaxial connector in the upper left corner. Also introduced via a 3

  5. Optimal Mid-Course Modifications of Ballistic Missile Trajectories

    DTIC Science & Technology

    1975-12-01

    consilered in the cost. The Impulse required to transfer from the nominal to the modified trajectory is directly related to the amount of propellant used by...exactly. For the example considered, the routine was teri -nated when velocity change at the point of trajectory modification changed only slightly, beyond...transfer, only transfer to a modified orbit apogee was considered. This could be extended to analyze transfer from a nominal orbit to a coaxial elliptic

  6. The Role of Meteorological Satellites in Tactical Battlefield Weather Support.

    DTIC Science & Technology

    1982-03-17

    system uses hydrazine as a mono- propellant . Each of the four pitch/yaw hydrazine thrusters produces 155 lbs of vacuum thrust and can be reduced on command...between spun outside diameter is 84.5 inches. Spacecraft spin motion and despun parts of the three-channel coaxial rotary at a rate of 100 rpm provides a...scanning. VAS thrust tube, equipment shelf, electronics, bat- teries , main wire harness, hydrazine tanks, thrusters, Despun S band and UHF antennas

  7. AFRRI (Armed Forces Radiobiology Research Institute) Reports, April-June 1989.

    DTIC Science & Technology

    1989-07-01

    virus - humian Culture. svhereas 37C( favors deveclopment of’ the pd uciL ng pam kaging cells, and( then fuir ariother 6i das s in stroial adhecrent la...deII Li elu NIU N1.tMnie I ides bac- teries se: retrilus in dan’. le’ folli1cl plii’itICrs aUtre’. sont phaipii\\ tci’’ par les cellule’. lf tiphoidi’v

  8. A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Rifaximin for the Prevention of Travelers’ Diarrhea in US Military Personnel Deployed to lncirlik Air Base, lncirlik, Turkey

    DTIC Science & Technology

    2010-01-01

    Following bacterial diarrhea, viruses are the next most common, generally responsible for about 5-10% of infectious diarrhea among travelers. 23...being cured by 72 hours. It should be noted for individuals with diarrhea secondary to viruses , antibiotics will not be effective, although symptoms...and safety of the antimo- tility plus antibiotic combination therapy with dyse~ tery . . · Expedient and Judicious Use of Treatment in Deployme~t Setti

  9. Resilient Military Systems and the Advanced Cyber Threat

    DTIC Science & Technology

    2013-01-01

    the Advanced Cyber Threat DoD CIO Briefing Ms. Teri Takai DoD CIO Cyber Law and Policy Dr. Catherine Lotrionte Georgetown University Law Center...e.g., Windows password-protected screen saver) 2. The BU shall use approved tools to defend against viruses , spyware, and other malicious code on...networks 3. The BU shall im plement an anti- virus program plan that, at a minimum: a) Has all required procedures for virus and malicious code

  10. Production of a Novel OX40 Ligand for Clinical Use

    DTIC Science & Technology

    2012-10-01

    Teri Tanquist, BS Todd Quinn, BS Jean Mesarich, AA Vice President Testing and Service Development Vice President of Process Improvement and...To demonstrate that a test article consisting of a master or working cell bank, virus seed lot, control cells, virus harvest, bulk vaccine or final...cell structure and function. Among other things, mycoplasma may affect cell antigenicity, interfere with virus replication and mimic viral actions

  11. Phase 1 IWAR Test Results

    DTIC Science & Technology

    2010-01-01

    tutoring “auditions”) and subject-matter mas- tery of an IT subdomain needed for the ACE/CID training. Another quarter of the instructors had written...and intractable problems, such as losing an Exchange database, cross-connected switches, looped hubs, viruses , and corrupted Active Directory. These...made registry changes on several servers to install anti- virus software on the ship’s Secret Internet Protocol Router Network (SIPRNET), reloaded a

  12. Interleukin-15 Increases Vaccine Efficacy through a Mechanism Linked to Dendritic Cell Maturation and Enhanced Antibody Titers

    DTIC Science & Technology

    2007-11-26

    Enhanced Antibody Titers Kamal U. Saikh,* Teri L. Kissner, Steven Nystrom, Gordon Ruthel, and Robert G. Ulrich Department of Immunology, Army Medical...Katsikis. 2005. Interleukin-15 increases effector memory CD8 T cells and NK cells in simian immunodeficiency virus -infected macaques. J. Virol. 79: 4877...vaccinia viruses express- ing IL-15 but not IL-2 induces long-lasting cellular immunity. Proc. Natl. Acad. Sci. USA 100:3392–3397. 24. Ohteki, T. 2002

  13. An Engineering Report in Civil Engineering and Management.

    DTIC Science & Technology

    1987-12-01

    ABSTRACT For United States Naval Mobile Construction Battalions (NMCBs), the greatest challenge for construction operations is the effective ...capable of providing responsive and effective means of establishing and lp maintaining the flow of men and m~teriAl to forward areas. This engineer...commanders and their staffs provide directive policy guidance to assigned NCF components in such areas as leadership and discipline; administration; contingenr

  14. Operations Research/Systems Analysis.

    DTIC Science & Technology

    1969-06-01

    and t h e s i c - m e - c t c - t c - i~ I i ve’s are t h e - I oc ’a I pot cit Prolca I c - i _ c mos t is ~‘a m w- el I ron war g,iri1i - ’~ s...examining how total sys tem resource requirements or coats change as key sys tem charac teris- tics are varied over a relevant range . Delphi Technique

  15. Determining Clinically Relevant Changes in Community Walking Metrics to Be Tracked by the VA as Part of Routine Care in Lower Limb Amputee Veterans

    DTIC Science & Technology

    2016-10-01

    Routine Care in Lower Limb Amputee Veterans PRINCIPAL INVESTIGATOR: Teri Chou, PhD CONTRACTING ORGANIZATION: Modus Health , LLC Washington, DC...Relevant Changes in Community Walking Metrics to Be Tracked by the VA as Part of Routine Care in Lower Limb Amputee Veterans 5c. PROGRAM ELEMENT...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Modus Health , LLC 123 Second Ave South

  16. Minimax Methods for Indefinite Functionals.

    DTIC Science & Technology

    1984-01-01

    Subadditivityt Y(A U B) 4 Y(A) + y(S). 40 Continuity proverty : If A is compact, Y(A) ( and there in a 6 > 0 such that y(A) - Y(Na(A)). Proofs 40 is...index tery is a mapping i : E + VU(-) such that for all A, B e E, *’ 10 Normalizations If x 0 Fix G, then i ( U gx) - 1. " 20 Mapping proverty : If f e

  17. A Comparative Analysis of Equatorial and Auroral-Zone Phase Scintillation Data

    DTIC Science & Technology

    1986-10-01

    AUTHOR(S) Rino, Charles L. and Dabbs , Teri M. 13a TYPE OF REPORT 13b. TIME COVERED 14. DATE OF REPORT (Year Month, Day) 15 PAGE COUNT Technical FROM850313...which lepend on wavelength and distance through Eq. (2), can also be measured. In a companion report [Livingston and Dabbs , 1986 (hereafter referred...10,526 (December 1982). Livingston, R. C., private communication, 1986. Livingston, R. C., and T. M. Dabbs , "Phase Scintillation Under Weak and

  18. The Effect of Hyperbaric Oxygen on the Growth of Rhizopus nigricans.

    DTIC Science & Technology

    1980-12-01

    identify by block number) Impression Chamber Medical Mycology Oxygen Therapy (ompression Therapy Mucor Phycomycosis hvp)erbaric Medicine Mucormycosis ... mucormycosis caused by Rhizopus SDD , ,, ,, 147 TO 1 NOV 65 IS OBSOLETE UNCLASSIFIED SECUFITY Cl.kSSIFICATION OF THIS PAGE (When Dfra F..tery_* K...0i 1 -’ & cl . TWO ca;cS of mucormycosis have been treated At I- i , ,vbar. Mdicine Division, USAF School of Aerospace Medicine. I v:, rhaI r i .v 1

  19. Triterpenoids from Psidium guajava with Biocidal Activity

    PubMed Central

    Ghosh, P.; Mandal, A.; Chakraborty, P.; Rasul, M. G.; Chakraborty, Madhumita; Saha, A.

    2010-01-01

    In continuation of our studies on the phytochemical investigation of medicinal plants available in the foothills of Darjeeling and Teri, we report herein the isolation of two triterpenoids betulinic acid and lupeol from the leaf extract of Psidium guajava and their potential antimicrobial and phytotoxic activities. All the structures of the isolated compounds were confirmed by spectral (IR, NMR) analysis and by comparison with the literature reports. PMID:21218065

  20. Review of Siding Materials for Turnkey Procurement of Army Family Housing.

    DTIC Science & Technology

    1984-09-01

    Engineers (OCE), under reimbursable Funding Authority Document (FAD) 2-270, dated October 1983. Appreciation is expressed to John Bukowski , USA-CERL-EM...lAiborstory. 1984. 49 p.. (Specii1 rport .M-360) I. IJ.~ l~ di ma.teri..) - I.. Jf~atfotkv. r, litic. It. Setles All, 0.,.,. -I i , i Ion Iin Ii-itnlg Rr,.’arcI taIoratnry) M-36, !OA ATE =MED 4 * WOMEN " I

  1. ARCHIE, FLAK, AAA, AND SAM A Short Operational History of Ground-Based Air Defense

    DTIC Science & Technology

    1988-12-01

    continent. American flak also made an impressive showing in com- bat (fig . 13) . During the Normandy campaign (7 through 30 June 1944), First Army...increasing burden. The AAF lost 18,418 aircraft in com- bat against Germany in World War 11 . The American air- men credited antiaircraft artillery with...Libyan air de- fenses were both large and sophisticated for a third world country. Besides MiGs, the defenses consisted of 100 bat - teries of SA-2s, SA

  2. Computational Model of the Complex between GR113808 and the 5-HT4 Receptor Guided by Site-Directed Mutagenesis and the Crystal Structure of Rhodopsin

    NASA Astrophysics Data System (ADS)

    López-Rodríguez, María L.; Murcia, Marta; Benhamú, Bellinda; Olivella, Mireia; Campillo, Mercedes; Pardo, Leonardo

    2001-11-01

    A computational model of the transmembrane domain of the human 5-HT4 receptor complexed with the GR113808 antagonist was constructed from the crystal structure of rhodopsin and the putative residues of the ligand-binding site, experimentally determined by site-directed mutagenesis. The recognition mode of GR113808 consist of: (i) the ionic interaction between the protonated amine and Asp3.32; (ii) the hydrogen bond between the carbonylic oxygen and Ser5.43; (iii) the hydrogen bond between the ether oxygen and Asn6.55; (iv) the hydrogen bond between the C-H groups adjacent to the protonated piperidine nitrogen and the π electrons of Phe6.51; and (v) the π-σ aromatic-aromatic interaction between the indole ring and Phe6.52. This computational model offers structural indications about the role of Asp3.32, Ser5.43, Phe6.51, Phe6.52, and Asn6.55 in the experimental binding affinities. Asp3.32Asn mutation does not affect the binding of GR113808 because the loss of binding affinity from an ion pair to a charged hydrogen bond is compensated by the larger energetical penalty of Asp to disrupt its side chain environment in the ligand-free form, and the larger interaction between Phe6.51 and the piperidine ring of the ligand in the mutant receptor. In the Phe6.52Val mutant the indole ring of the ligand replaces the interaction with Phe6.52 by a similarly intense interaction with Tyr5.38, with no significant effect in the binding of GR113808. The mutation of Asn6.55 to Leu replaces the hydrogen bond of the ether oxygen of the ligand from Asn6.55 to Cys5.42, with a decrease of binding affinity that approximately equals the free energy difference between the SH⋯O and NH⋯O hydrogen bonds. Because these residues are also present in the other members of the neurotransmitter family of G protein-coupled receptors, these findings will also serve for our understanding of the binding of related ligands to their cognate receptors.

  3. Crotogossamide, a cyclic nonapeptide from the latex of Croton gossypifolius.

    PubMed

    Quintyne-Walcott, Simone; Maxwell, Anderson R; Reynolds, William F

    2007-08-01

    A new cyclic nonapeptide, crotogossamide (1), was isolated from the latex of Croton gossypifolius. Its structure was elucidated by use of 1D and 2D NMR and MS and by hydrolysis followed by GC-MS analysis as cyclo(-Gly(1)-Ala(2)-Ser(3)-Gly(4)-Leu(5)-Asn(6)-Gly(7)-Ile(8)-Phe(9)-). This is the first report of a cyclic peptide from a Croton species. The known flavonoids kaempferol 3-O-rhamnopyranoside, quercitrin, and myricitrin were also isolated from the plant latex.

  4. GIS-based Stress Field Modeling of the North Arm of Sulawesi (NAoS) and its application in mineral prospectivity assessment

    NASA Astrophysics Data System (ADS)

    Albert, Gáspár; Szentpéteri, Krisztián

    2017-04-01

    Remotely sensed and digital map data are useful sources for regional structural analysis, including stress calculations. If the type of a given fault is determined and is considered as Andersonian, and rather juvenile instead of a reactivated one, the tectonic stress can be calculated for each of the fault segments (Albert et al. 2016). The North Arm of Sulawesi, a west-east-trending land strip of the irregular shaped Sulawesi Island, is actively deforming and the upper plate tectonic setting is quite complex in this region since it is situated above a triple junction of the Eurasian, Pacific and Australian plates. The stress currently acting in this region not only creates neotectonics but triggers subduction-related volcanism shifting from west to east on the peninsula. The volcanic centers - adjacent to transfer faults and the colliding plates at depth - appear to be the most productive areas for epithermal-porphyry mineralization systems of economic potential (Szentpéteri et al. 2015). In this work we demonstrate how the derived stress field model helps to understand the location and clustering of various mineralization types in the NAoS. We examine if this method is applicable for mineral prospectively assessments. References Albert, G., Barancsuk, Á., and Szentpéteri, K., 2016, Stress field modelling from digital geological map data: Geophysical Research Abstracts, v. 18, EGU2016-14565. Szentpéteri, K., Albert, G., and Ungvári, Z., Plate tectonic - and stress field - modeling of the North Arm of Sulawesi, Indonesia, to better understand distribution of mineral deposits styles., in Proceedings SEG 2015 I World Class Ore Deposits: Discovery to Recovery, Wrest Point Convention Centre, Hobart, Australia, September 27 - 30. 2015.

  5. Phosphite Utilization by the Globally Important Marine Diazotroph Trichodesmium

    NASA Astrophysics Data System (ADS)

    Polyviou, D.; Hitchcock, A.; Baylay, A. J.; Moore, C. M.; Bibby, T. S.

    2016-02-01

    The marine cyanobacterium Trichodesmium is responsible for a significant fraction of oceanic nitrogen fixation and plays a key role in biogeochemical processes in the contemporary ocean. It has recently been shown that it also contributes to an emerging oceanic phosphorus (P) redox cycle. This is of interest as the availability of P constrains the growth of Trichodesmium in large expanses of the tropical and subtropical oceans. A four-gene cluster (ptxABCD) encodes a putative ABC transporter (ptxABC) and NAD-dependent dehydrogenase (ptxD) and is suggested to be involved in utilisation of the reduced inorganic compound phosphite. The gene cluster is identified in the Trichodesmium erythraeum IMS101 genome (Tery_0365-0368). Here, we report the occurrence of these genes in available in-situ metagenomic and metatranscriptomic datasets confirming the presence and expression of ptxABCD in diverse Trichodesmium species in the field. We also demonstrate that T.erythraeum IMS101 in culture can grow on phosphite as its sole source of P. The current lack of an established system for genetic manipulation of this organism inhibits direct functional characterisation of ptxABCD. To circumvent this we exploit the model cyanobacteria Synechocystis PCC6803 as a vehicle for the heterologous expression of the Trichodesmium genes. We demonstrate that only combined expression of both the transporter and the dehydrogenase enables Synechocystis to utilize phosphite, confirming the function of Tery_0365-0367 as a phosphite uptake system (PtxABC) and Tery_0368 as a phosphite dehydrogenase (PtxD). Our findings suggest that previously reported uptake of phosphite by Trichodesmium consortia in the field likely reflects an active biological process by Trichodesmium itself. These results highlight the diversity of phosphorus sources available to Trichodesmium in a resource-limited ocean and also the power of using heterologous gene expression to determine the function of genes identified in

  6. Emplacement Scenarios for Vallis Schroteri, Aristarchus Plateau, the Moon

    NASA Technical Reports Server (NTRS)

    Garry, W. Brent; Bleacher, Jacob E.

    2011-01-01

    The volcanic processes that formed Vallis Schr teri are not well understood. Vallis Schr teri, located on the Aristarchus Plateau, is the largest rille on the Moon, and it displays three key morphologic components: the Cobra Head, the 155-km-long primary rille, and the 240-km-long inner rille. Observations of terrestrial eruptions are applied here to help explain the morphologic relationships observed for Vallis Schr teri. The Cobra Head, a 10-km-wide source vent surrounded by a 35-kmdiameter and 900-m-high low shield, might have been constructed from fl ows, spatter, and pyroclastic deposits erupted during lava fountain events, similar to the early stages of the vent at Pu u O o in Hawaii and the fi nal morphology of Bandera crater, a cinder cone in New Mexico. The vent fed an initial sheet fl ow controlled by preeruption topography. A channel formed within this sheet fl ow was the foundation for the primary rille, which deepened through construction and thermomechanical erosion by lava. The inner rille is confi ned to the fl at fl oor of the primary rille and is characterized by tight gooseneck meanders. This rille crosscuts the distal scarp of the primary rille and extends toward Oceanus Procellarum. This enigmatic relationship can be explained through backup, overfl ow, and diversion of the lava into a new rille that eroded into the margin of the primary rille. Similar backup, overfl ow, and redirection of the lava fl ow were observed during the 1984 Mauna Loa eruption in Hawaii. Analysis of the fi nal morphology of lunar rilles provides key information about lunar volcanic processes and insight into the local stratigraphy.

  7. Proceedings of the ERDC-CERL Net Zero Energy (NZE) Installation and Deployed Bases Workshop Held in Colorado Springs, CO. on 3-4 Feb 2009

    DTIC Science & Technology

    2009-06-01

    Wauke- sha, Caterpillar , or General Electric (via its subsidiary Jenbacher) are of- fering their products in Europe and making good business, others are...application of amor- phous, thin film photoelectric to the surface of shade structures and bat- tery recharging mats. A small, wall-less PV shade tent can...generate 1 kW of power while a medium-sized shade tent can generate 2 kW. The tents can power portable 1 kW batteries with integrated DC to AC

  8. An Algebraic Specification Language and a Syntax Directed Editor.

    DTIC Science & Technology

    1984-12-01

    the various parts of specification produced by the language and describes an experimental syntax directed editor which uses the language’s grammar .. N...y t he ldngua ;ke aL>: describes an experimental syntax iirected eiitic w..icil~~s. the language’s grammar . 4 N 71 1ABLE OF CC4TENTS " i1TRODJCTION...zfinai _Lcif_;a.ioa. explandtion, of the neta-sym-hols useLd to ioco.cc teri-ia± * strings ir. the grammar are as fcliows: < > - A iname enclosed by

  9. Diakoptic Theory for Multielement Antennas

    DTIC Science & Technology

    1982-01-01

    FOR MULTIELEMENT ANTENNAS 21 formulation of the antenna problem in terIs of this approx- 2L imate impedance matrix can also be dei in a more con- 4 2 2... Mittra , University of llinois, for help- € i New Delhi, India, on November 30. 1933. He oo received the bachelor’s degree in electrical ful suggestions...and with Messerschmidt-Bolkow-Blohm of Germany in Flectromagnetics. R. Mittra , Ed. New York: Pergamon, 1973. the area of dual spin diagnosis and

  10. The relief formed by the descent phenomenon in the north-east part of Kosova.

    PubMed

    Bulliqi, Shpejtim; Isufi, Florim; Ramadani, Ibrahim; Gashi, Gani

    2012-04-01

    In the diverse relief of north-east part of Kosova a relatively wide range occupies the relief modelled by the descent phenomenon, which is conditioned by morph-structural and climatic factors quite suitable for their development. The morphogenesis activity of descent phenomenon is conditioned by the types of rocks, tectonic process of this region and climatic conditions. These factors condition horizontal and vertical relief fragmentation, slope, especially in Gollaku mountains and in SE part of Kopaonik mountain. Along the tectonic descents, the steepness is detaching and the detaching lines consisting of magmatic rocks show overthrows, demolitions and stony torrents, but the Teri gene composition formations are modelled by sliding and muddy torrents, depending upon the presence of clayey and alevrolite belts on these Teri gene ones. The impact of factors and conditions on the relief of this part, the phenomena like demolitions, overthrows, sliding, muddy torrents, stony torrents, etc, operate here, which play an important morphological role in the modelling of relief.

  11. Purification and characterization of exopolysaccharide bioflocculant produced by heavy metal resistant Achromobacter xylosoxidans.

    PubMed

    Subudhi, Sanjukta; Bisht, Varsha; Batta, Neha; Pathak, Mihirjyoti; Devi, Arundhuti; Lal, Banwari

    2016-02-10

    Optimization of process parameters enhanced bioflocculating activity of 'Achromobacter xylosoxidans strain TERI L1' from 75% to 83.3% in absence of heavy metals, which decreased to 73% in presence of multi-metals. 'TERI L1' could adsorb 90% of multi-metals when grown in presence of 1250 mg L(-1) Zn, 2 mg L(-1) Cd, 30 mg L(-1) Pb, 200 mg L(-1) Ni and 90 mg L(-1) Cu and could adsorb 1100 mg L(-1) of Pb when grown in presence of 1500 ppm lead nitrate. The bioflocculant was purified and characterized. Bioflocculant yield was 5 g L(-1). Fourier transform infrared spectrum indicated presence of carboxyl, hydroxyl, amino groups, typical of glycoprotein. Spectroscopic analysis of bioflocculant by nuclear magnetic resonance revealed that it is a glycoprotein. LC-MS analysis confirmed the bioflocculant as a carbohydrate hetero polymer. Bioflocculant was composed of 75% total sugar with 72.9% neutral sugar and 11.5% protein. Scanning Electron Micrography revealed effective flocculation of kaolin clay by purified exopolysaccharide bioflocculant. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. It's not about energy--it's about power!

    PubMed

    Blanton, Teri

    2014-01-01

    Teri Blanton is a former chairperson and current fellow at Kentuckians for the Commonwealth, a statewide organization that works "for a new balance of power and a just society aimed at changing unfair political, economic, and social systems." In March 2014 she was a keynote speaker addressing the annual conference of the Toxics Action Center in Boston, Massachusetts. We are publishing her speech, presented to the many environmental activists from community- and labor-based organizations that work on state and regional concerns. Ms. Blanton energized the conference with her message of persistent organizing to attain justice against the threats posed to our communities, health, and environment by powerful forces who exploit our lives and labor for their profit and power. She calls upon us to build the power to make the transition to more sustainable and democratic human development.

  13. Report on marine mammal stranding

    NASA Astrophysics Data System (ADS)

    Kumar, Mohi

    2006-06-01

    The U.S. National Oceanic and Atmospheric Administration (NOAA) released a report on 27 April indicating that U.S. Navy sonar transmissions may have played a role in the stranding of more than 150 melon-headed whales on 3 July 2004 off the coast of Kauai, Hawaii. At the time of the stranding, which resulted in one whale death, the Navy was preparing to conduct sonar activities as part of a military exercise. The report notes that six naval surface vessels transiting to the area on the previous night intermittenly transmitted mid-frequency active sonar. That activity is ``a plausible, if not likely, contributing factor'' to the stranding event. There was no significant weather, natural oceanographic event, or known biological factors that would explain the animals' movement into the bay nor the group's continued presence in the bay, according to report lead author Teri Rowles, NOAA marine mammal veterinarian.

  14. A replica of the Olympic torch is recovered from STS-101 Atlantis

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Teri McKinney, with Shuttle Crew Escape, Johnson Space Center, holds a replica of the Olympic torch carried aboard Space Shuttle Atlantis on mission STS-101. The addition of the torch to the payload was coordinated by astronaut Andy Thomas, who is from Australia. The torch will travel to Australia for the 2000 Olympic games being held there in September. . STS-101 was the third flight to the International Space Station and included repairs to the Station plus transfer of equipment and supplies to the Station for future missions. The landing of Atlantis completed a 9-day, 20-hour, 9-minute-long mission. It was the 98th flight in the Space Shuttle program and the 21st for Atlantis. The landing was the 51st at KSC, the 22nd consecutive landing at KSC, the 14th nighttime landing in Shuttle history and the 29th in the last 30 Shuttle flights.

  15. Conceptual Designs for Berthing Pier Galleries and Deck Lighting.

    DTIC Science & Technology

    1983-06-01

    CONCEI’FS I Ie ~ L ),I Ic L’ Outs(’I it S f0 to - h~o 1 11 t ’ p) i lI-s Hiypo r t ed )i p L, r :1i,1 1 0 1 t Ilt’ 1’jIL i llj, p1it’ tnt’ il is d tipo )01...le-stipportedI p)ieur alI teri te0. 2.4.2 F lo~jn _IIiY The gal I elC -v sct i On -1cci t fo0r t 11 flIoa t i ut ,p pie r i s s iila’Ir t o the con

  16. (Collaborative coal project between the USA and India)

    SciTech Connect

    Krishnan, R.P.

    1990-10-05

    Under the Phase II, Alternative Energy Resources Development (AERD) project of the United States Agency for International Development (USAID) and the Government of India (GOI), five collaborative coal projects have been initiated in the areas of: (1) NO{sub x}/SO{sub x} control from coal-fired power plants, (2) slagging combustor development for high-ash Indian coals, (3) characterization of Indian coals for combustion and gasification. (4) diagnostic studies for prediction of power plant life expectancy, and (5) environmental and natural resource analysis of coal cycle. The Pittsburgh Energy Technology Center (PETC) has the implementation responsibility for these projects. The Indian collaborative institutions identified for these projects are the Bharat Heavy Electricals Ltd. (BHEL), Trichy, (projects 1--4), and the Tata Energy Research Institute (TERI) for project 5. The Oak Ridge National Laboratory (ORNL) is providing cross-cut technical coordination and support for these five projects.

  17. (Coal utilization in India)

    SciTech Connect

    Krishnan, R.P.

    1991-01-15

    Under the Phase II, Alternative Energy Resources Development (AERD) project of the United States Agency for International Development (USAID) and the Government of India (GOI), five collaborative coal projects have been initiated in the areas of: (1) NO{sub x}/SO{sub x} control from coal-fired power plants, (2) slagging combustor development for high-ash Indian coals, (3) characterization of Indian coals for combustion and gasification, (4) diagnostic studies for prediction of power plant life expectancy, and (5) environmental and natural resource analysis of coal cycle. The Pittsburgh Energy Technology Center (PETC) has the implementation responsibility for these projects. The Indian collaborative institutions identified for these projects are the Bharat Heavy Electricals Ltd. (BHEL), Trichy, (Projects 1--4), and the Tata Energy Research Institute (TERI) for Project 5. The Oak Ridge National Laboratory (ORNL) is providing cross-cut technical coordination and support for these five projects.

  18. Assessment of YouTube videos as a source of information on medication use in pregnancy.

    PubMed

    Hansen, Craig; Interrante, Julia D; Ailes, Elizabeth C; Frey, Meghan T; Broussard, Cheryl S; Godoshian, Valerie J; Lewis, Courtney; Polen, Kara N D; Garcia, Amanda P; Gilboa, Suzanne M

    2016-01-01

    When making decisions about medication use in pregnancy, women consult many information sources, including the Internet. The aim of this study was to assess the content of publicly accessible YouTube videos that discuss medication use in pregnancy. Using 2023 distinct combinations of search terms related to medications and pregnancy, we extracted metadata from YouTube videos using a YouTube video Application Programming Interface. Relevant videos were defined as those with a medication search term and a pregnancy-related search term in either the video title or description. We viewed relevant videos and abstracted content from each video into a database. We documented whether videos implied each medication to be "safe" or "unsafe" in pregnancy and compared that assessment with the medication's Teratogen Information System (TERIS) rating. After viewing 651 videos, 314 videos with information about medication use in pregnancy were available for the final analyses. The majority of videos were from law firms (67%), television segments (10%), or physicians (8%). Selective serotonin reuptake inhibitors (SSRIs) were the most common medication class named (225 videos, 72%), and 88% of videos about SSRIs indicated that they were unsafe for use in pregnancy. However, the TERIS ratings for medication products in this class range from "unlikely" to "minimal" teratogenic risk. For the majority of medications, current YouTube video content does not adequately reflect what is known about the safety of their use in pregnancy and should be interpreted cautiously. However, YouTube could serve as a platform for communicating evidence-based medication safety information. Copyright © 2015 John Wiley & Sons, Ltd.

  19. ASSESSMENT OF YOUTUBE VIDEOS AS A SOURCE OF INFORMATION ON MEDICATION USE IN PREGNANCY

    PubMed Central

    Hansen, Craig; Interrante, Julia D; Ailes, Elizabeth C; Frey, Meghan T; Broussard, Cheryl S; Godoshian, Valerie J; Lewis, Courtney; Polen, Kara ND; Garcia, Amanda P; Gilboa, Suzanne M

    2015-01-01

    Background When making decisions about medication use in pregnancy, women consult many information sources, including the Internet. The aim of this study was to assess the content of publicly-accessible YouTube videos that discuss medication use in pregnancy. Methods Using 2,023 distinct combinations of search terms related to medications and pregnancy, we extracted metadata from YouTube videos using a YouTube video Application Programming Interface. Relevant videos were defined as those with a medication search term and a pregnancy-related search term in either the video title or description. We viewed relevant videos and abstracted content from each video into a database. We documented whether videos implied each medication to be ‘safe’ or ‘unsafe’ in pregnancy and compared that assessment with the medication’s Teratogen Information System (TERIS) rating. Results After viewing 651 videos, 314 videos with information about medication use in pregnancy were available for the final analyses. The majority of videos were from law firms (67%), television segments (10%), or physicians (8%). Selective serotonin reuptake inhibitors (SSRIs) were the most common medication class named (225 videos, 72%), and 88% percent of videos about SSRIs indicated they were ‘unsafe’ for use in pregnancy. However, the TERIS ratings for medication products in this class range from ‘unlikely’ to ‘minimal’ teratogenic risk. Conclusion For the majority of medications, current YouTube video content does not adequately reflect what is known about the safety of their use in pregnancy and should be interpreted cautiously. However, YouTube could serve as a valuable platform for communicating evidence-based medication safety information. PMID:26541372

  20. Effect of radiation and non radiation environmental factors on children hematopoietic system.

    PubMed

    Bebeshko, V G; Bruslova, K M; Stankevych, V V; Tsvietkova, N M; Lyashenko, L O; Galkina, S G; Pushkaryova, T I; Kolos, V I; Kuznetsova, O Ye; Honchar, L O; Yatsemyrskii, S M; Samson, Y M

    2016-12-01

    Meta. Vyznachyty vplyv radiatsiy̆nykh ta neradiatsiy̆nykh chynnykiv dovkillia na rozvytok zmin v gemopoezi u ditey̆ ta obґruntuvaty kryteriï formuvannia grupy pidvyshchenogo ryzyku rozvytku gematologichnoï patologiï.Materialy i metody. Predstavleni rezul'taty kliniko gematologichnogo obstezhennia 1465 ditey̆, zhyteliv Kyïvs' koï, Zhytomyrs'koï ta Chernigivs'koï oblastey̆ za period z 2008 r. po 2014 r. Z nykh: 777 ditey̆ z anemiiamy, 466 – zi zminamy v gemogramakh, 191 – z gostrymy ley̆kemiiamy. Otsiniuvaly dozy oprominennia ditey̆, zv’iazok stupenia integ ral'nogo zabrudnennia terytoriy̆ z pokaznykamy gemopoezu ta perebigom gematologichnoï patologiï. U 121 dytyny vyznachaly vmist metaliv u volossi, nigtiakh i krovi.Rezul'taty. Vstanovleni nay̆bil'sh chasti prychyny rozvytku anemiy̆ u ditey̆, osoblyvosti perebigu gostrykh ley̆ kemiy̆ zalezhno vid stupenia integral'nogo zabrudnennia terytoriï. Dolia ditey̆, zhyteliv duzhe zabrudnenykh tery toriy̆ z pro V GLL ta T GLL z initsial'nym ley̆kotsytozom ta nespryiatlyvym perebigom zakhvoriuvannia, bula bil' shoiu porivniano z doleiu khvorykh pomirno zabrudnenykh regioniv (r = –0,47). Vstanovlenyy̆ priamyy̆ koreliatsiy̆nyy̆ zv’iazok mizh vidsotkom ditey̆ z monotsytozamy ta stupenem zabrudnennia terytoriï: na duzhe zabrudnenykh tery toriiakh prozhyvalo 20,2 % takykh ditey̆, na pomirno zabrudnenykh – 10,3 % (r < 0,05). Vmist Pb, Cu, Cr, Mn, Zn u biologichnykh tkanynakh ditey̆ ne perevyshchuvav dopustymi vidnosno GDK. Riven' Zn v usikh ditey̆ znakhodyvsia na nyzhniy̆ mezhi normatyvnogo. Indyvidual'ni rivni metaliv u volossi, nigtiakh ta krovi ne zalezhaly vid stati khvorykh ta dozy oprominennia. Obgruntovani kryteriï formuvannia grupy pidvyshchenogo ryzyku rozvytku onkogemato logichnoï patologiï u ditey̆, iaki prozhyvaiut' v ekologichno nespryiatlyvykh regionakh.Vysnovky. Radiatsiy̆ni ta neradiatsiy̆ni chynnyky dovkillia vplyvaiut' na rozvytok zmin v

  1. Affinity enhancement of HER2-binding Z(HER2:342) affibody via rational design approach: a molecular dynamics study.

    PubMed

    Ghaffari, Mohammad Ali; Zeinali, Majid; Barzegari Asadabadi, Ebrahim; Jamalan, Mostafa; Jahandideh, Samad

    2014-12-01

    Human epidermal growth factor receptor 2 (HER2) contributes to the development of breast cancers and malignancies. On the other hand, engineered affibody Z(HER2:342) that binds to HER2 can be successfully used for both diagnostic purposes and specific ablation of malignant HER2-positive cell lines. In the current study, electrostatics-based prediction was applied for improving Z(HER2:342) binding affinity using computational design. The affibody Z(HER2:342) alone and in complex with HER2 was energetically minimized, solvated in explicit water, and neutralized. After heating and equilibration steps, the system was studied by isothermal-isobaric (NPT) MD simulation. According to trajectories, Z(HER2:342) specifically binds to HER2 through hydrogen bonds and salt bridges. Based on the electrostatic binding contributions, two affinity-matured variants namely V1 (Tyr35Arg) and V2 (Asn6Asp and Met9Glu) were rationally designed. More investigations through MD simulation show that V1 interacts with HER2 receptor more strongly, compared to Z(HER2:342) and V2.

  2. Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity

    PubMed Central

    Jones, Stephen K.; Clarke, Starlynn C.; Craik, Charles S.

    2015-01-01

    ABSTRACT Peptide-based pheromones are used throughout the fungal kingdom for coordinating sexual responses between mating partners. Here, we address the properties and function of Bar1, an aspartyl protease that acts as a “barrier” and antagonist to pheromone signaling in multiple species. Candida albicans Bar1 was purified and shown to exhibit preferential cleavage of native α pheromone over pheromones from related fungal species. This result establishes that protease substrate specificity coevolved along with changes in its pheromone target. Pheromone cleavage by Bar1 occurred between residues Thr-5 and Asn-6 in the middle of the tridecapeptide sequence. Surprisingly, proteolytic activity was independent of the amino acid residues present at the scissile bond and instead relied on residues at the C terminus of α pheromone. Unlike most aspartyl proteases, Bar1 also exhibited a near-neutral pH optimum and was resistant to the class-wide inhibitor pepstatin A. In addition, genetic analysis was performed on C. albicans BAR1 and demonstrated that the protease not only regulates endogenous pheromone signaling but also can limit interspecies pheromone signaling. We discuss these findings and propose that the unusual substrate specificity of Bar1 is a consequence of its coevolution with the α pheromone receptor Ste2 for their shared peptide target. PMID:26604258

  3. Endoscopic therapy for weight loss: Gastroplasty, duodenal sleeves, intragastric balloons, and aspiration

    PubMed Central

    Kumar, Nitin

    2015-01-01

    A new paradigm in the treatment of obesity and metabolic disease is developing. The global obesity epidemic continues to expand despite the availability of diet and lifestyle counseling, pharmacologic therapy, and weight loss surgery. Endoscopic procedures have the potential to bridge the gap between medical therapy and surgery. Current primary endoscopic bariatric therapies can be classified as restrictive, bypass, space-occupying, or aspiration therapy. Restrictive procedures include the USGI Primary Obesity Surgery Endolumenal procedure, endoscopic sleeve gastroplasty using Apollo OverStitch, TransOral GAstroplasty, gastric volume reduction using the ACE stapler, and insertion of the TERIS restrictive device. Intestinal bypass has been reported using the EndoBarrier duodenal-jejunal bypass liner. A number of space-occupying devices have been studied or are in use, including intragastric balloons (Orbera, Reshape Duo, Heliosphere BAG, Obalon), Transpyloric Shuttle, and SatiSphere. The AspireAssist aspiration system has demonstrated efficacy. Finally, endoscopic revision of gastric bypass to address weight regain has been studied using Apollo OverStitch, the USGI Incisionless Operating Platform Revision Obesity Surgery Endolumenal procedure, Stomaphyx, and endoscopic sclerotherapy. Endoscopic therapies for weight loss are potentially reversible, repeatable, less invasive, and lower cost than various medical and surgical alternatives. Given the variety of devices under development, in clinical trials, and currently in use, patients will have multiple endoscopic options with greater efficacy than medical therapy, and with lower invasiveness and greater accessibility than surgery. PMID:26240686

  4. [Measurement method of arterial shear stress of rats model based on ultrasonic particle imaging velocimetry].

    PubMed

    Xhu, Yiheng; Qian, Ming; Niu, Lili; Zheng, Hairong; Lu, Guangwen

    2014-12-01

    The development and progression of atherosclerosis and thrombosis are closely related to changes of hemodynamics parameters. Ultrasonic pulse wave Doppler technique is normally used for noninvasively blood flow imaging. However, this technique only provides one-dimensional velocity and depends on the angle between the ultrasound beam and the local velocity vector. In this study, ultrasonic particle image velocimetry method was used to assess whole field hemodynamic changes in normal blood vessels. By using the polynomial fitting method, we investigated the velocity gradient and assessed the shear in different blood flow velocity of 10 healthy rats. It was found that using four polynomial fitting could result in optimal measurement results. The results obtained by ultrasonic particle image velocimetry accorded with the results obtained using Doppler technique. The statistical average of cyclical vessel wall shear stress was positively related to the locational mean velocity. It is proven that ultrasonic particle image velocimetry method could be used to assess directly the real-time whole field hemodynamic changes in blood vessels and was non-invasively, and should be a good prosperous technique for monitoring complex blood flow in stenotic ar- teries.

  5. Viscoelastic evaluation of fetal umbilical vein for reconstruction of middle cerebral artery

    PubMed Central

    Li, Dongyuan; Xu, Donghui; Li, Peng; Wei, Jun; Yang, Kun; Zhao, Conghai

    2013-01-01

    The transplantation of artificial blood vessels with < 6 mm inner diameter as substitutes for human arterioles or veins has not achieved satisfactory results. Umbilical vein has been substituted for ar-tery in vascular transplantation, but it remains unclear whether the stress relaxation and creep tween these vessels are consistent. In this study, we used the fetal umbilical vein and middle cere-bral artery from adult male cadavers to make specimens 15 mm in length, 0.196–0.268 mm in nica media thickness, and 2.82–2.96 mm in outer diameter. The results demonstrated that the stress decrease at 7 200 seconds was similar between the middle cerebral artery and fetal umbilical vein specimens, regardless of initial stress of 18.7 kPa or 22.5 kPa. However, the strain increase at 7 200 seconds of fetal umbilical veins was larger than that of middle cerebral arteries. Moreover, the stress relaxation experiment showed that the stress decrease at 7 200 seconds of the fetal umbilical vein and middle cerebral artery specimens under 22.5 kPa initial stress was less than the decrease in these specimens under 18.7 kPa initial stress. These results indicate that the fetal umbilical vein has appropriate stress relaxation and creep properties for transplantation. These properties are advantageous for vascular reconstruction, indicating that the fetal umbilical vein can be transplanted to repair middle cerebral artery injury. PMID:25206626

  6. KSC-2012-1545

    NASA Image and Video Library

    2012-02-23

    ORLANDO, Fla. -- The winners of NASA’s Quality and Safety Achievement Recognition, or QASAR, awards for 2011 pose for a group portrait during NASA’s ninth annual Project Management Challenge. From left are Teri Hamlin, Johnson Space Center Joseph B. Hamilton, Kennedy Space Center Francis “Frank” Merceret, Kennedy Space Center and Venki Venkat, Langley Research Center. Kennedy retiree Humberto "Bert" T. Garrido, not pictured, also received the award. NASA's QASAR award recognizes individual government and contractor employees who have demonstrated exemplary performance in contributing to the quality or safety of products, services, processes, or management programs and activities. PM Challenge 2012 was held at the Caribe Royale Hotel and Convention Center in Orlando, Fla., on February 22-23, to provide a forum for all stakeholders in the project management community to meet and share stories, lessons learned and new uses of technology in the industry. The PM Challenge is sponsored by NASA's Office of the Chief Engineer. For additional information, visit http://www.nasa.gov/offices/oce/pmchallenge/index.html. Photo credit: NASA/Jim Grossmann

  7. Impact of battery degradation on energy arbitrage revenue of grid-level energy storage

    DOE PAGES

    Wankmüller, Florian; Thimmapuram, Prakash R.; Gallagher, Kevin G.; ...

    2017-01-19

    This study investigates the representation of battery degradation in grid level energy storage applications. In particular, we focus on energy arbitrage, as this is a potential future large-scale application of energy storage and there is limited existing research combining the modelling of battery degradation and energy storage arbitrage. We implement two different representations of battery degradation within an energy arbitrage model, and show that degradation has a strong impact on battery energy storage system (BESS) profitability. In a case study using historical electricity market prices from the MISO electricity market in the United States, we find that the achievable netmore » present value (at an interest rate of 10%) for a battery system with a C-rate of 1C dropped from 358 /kWh in the case considering no degradation to 194-314 /kWh depending on the battery degradation model and assumptions for end of life (EOL) criteria. This corresponds to a reduction in revenue due to degradation in the 12-46% range.Furthermore, we find that reducing the cycling of the bat-tery via introducing a penalty cost in the objective function of the energy arbitrage optimization model can improve the profitability over the life of the BESS.« less

  8. GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition.

    PubMed

    Kaushik, N; Agnihotri, A

    2000-12-01

    Rapeseed-mustard is one of the most economically important oilseed crops in India. Speciality oils having high amounts of a specific fatty acid are of immense importance for both nutritional and industrial purposes. Oil high in oleic acid has demand in commercial food-service applications due to a long shelf-life and cholesterol-reducing properties. Both linoleic and linolenic acids are essential fatty acids; however, less than 3% linolenic acid is preferred for oil stability. High erucic acid content is beneficial for the polymer industry, whereas low erucic acid is recommended for food purposes. Therefore, it is important to undertake systematic characterization of the available gene pool for its variable fatty acid profile to be utilized for specific purposes. In the present study the Indian rapeseed-mustard germplasm and some newly developed low-erucic-acid strains were analysed by GLC to study the fatty acid composition in these lines. The GLC analysis revealed that the rapeseed-mustard varieties being commonly grown in India are characterized by high erucic acid content (30-51%) in the oil with low levels of oleic acid (13-23%). However, from among the recently developed low-erucic-acid strains, several lines were identified with comparatively high oleic acid (60-70%), moderate to high linoleic acid (13-40%) and low linolenic acid (< 10%) contents. Work is in progress at TERI (New Delhi, India) to utilize these lines for development of strains with particular fatty acid compositions for specific purposes.

  9. Coomassie Brilliant Blue removal/disposal from gel destain and used gel stain in an environment-friendly manner.

    PubMed

    Kurien, Biji T; Dorri, Yaser

    2012-01-01

    Toxic reagents are employed to destain Coomassie Brilliant Blue (CBB) stained gels. We tested the efficacy of various paper adsorbents in adsorbing CBB released from gels during destaining. Kimwipes were the most efficient, followed by Teri towels, multifold towels, and Whatman (numbers 1 and 3) filter papers. Three Kimwipes added during destaining of a CBB-stained mini-gel helped adsorb the released dye. Thus, stain removal with Kimwipes helps reduce destain use and organic waste accumulation, enables recycling of nonradioactive destaining solution, and is 7.5-fold cheaper than an available method for CBB disposal. Next, we used Kimwipes to deplete the dye from a used CBB staining solution awaiting proper disposal by our Institutional Safety Office. Seventy-five Kimwipes successfully helped remove the dye from a 0.05% CBB staining solution in 5 to 10 min. The blue-colored Kimwipes did not release the stain even when squeezed dry after incubation in various salts, water, or acid solutions for five weeks. The CBB removed thus can be simply disposed as solid waste and will not leach out from solid landfills. Kimwipes, thus, enables CBB disposal in an environmentally friendly manner and allows recycling of destaining solution.

  10. Environmentally safe removal/disposal of Coomassie Brilliant Blue from gel destain and used gel stain.

    PubMed

    Dorri, Yaser; Kurien, Biji T

    2010-09-15

    Gel destaining following Coomassie Brilliant Blue (CBB) staining involves the use of toxic reagents. Here we demonstrate the efficacy of various paper adsorbents in adsorbing CBB. Kimwipes adsorbed the best, followed by Teri towels, multifold towels, and Whatman numbers 1 and 3 filter papers. Three Kimwipes completely adsorbed the dye released from a CBB-stained mini-gel. Nonradioactive destain solution can, therefore, be recycled for destaining CBB-stained gels. Stain removal with Kimwipes helps in reducing destain use and in reducing organic liquid waste, and it is 7.5-fold cheaper compared with an available method for CBB disposal. Following this, we determined the suitability of this procedure to remove the dye from a used CBB staining solution awaiting proper disposal by our Institutional Safety Office. The dye from a 0.05% CBB staining solution could be removed in 5 to 10 min using 75 Kimwipes. The CBB-adsorbed Kimwipes did not release the stain when squeezed dry even after incubation in various salts over 1week and in water for 5 weeks. The CBB removed allows its easy disposal as solid waste and will not leach out from solid landfills. Thus, stain removal with Kimwipes helps in disposing CBB in an environmentally friendly manner and allows recycling of destaining solution. 2010 Elsevier Inc. All rights reserved.

  11. Observation of "ionic lock" formation in molecular dynamics simulations of wild-type beta 1 and beta 2 adrenergic receptors.

    PubMed

    Vanni, Stefano; Neri, Marilisa; Tavernelli, Ivano; Rothlisberger, Ursula

    2009-06-09

    G protein coupled receptors (GPCRs) are a large family of integral membrane proteins involved in signal transduction pathways, making them appealing drug targets for a wide spectrum of diseases. The recently crystallized structures of two engineered adrenergic receptors have opened new avenues for the understanding of the molecular mechanisms of action of GPCRs. Taking the two crystal structures as a starting point, we carried out submicrosecond molecular dynamics simulations of wild-type beta(1) and beta(2) adrenergic receptors in a lipid bilayer under physiological conditions. These simulations give access to structural and dynamic properties of the receptors in pseudo in vivo conditions. For both systems the overall fold properties of the transmembrane region as well as the binding pocket remain close to the crystal structure of the engineered systems, thus suggesting that the ligand binding mode is not affected by the introduced modifications. Both simulations indicate the presence of one or two internal water molecules absent in both crystal structures and essential for the stabilization of the binding pocket at the interface between transmembrane helices III, IV, and V. The different interactions arising from the substitution of Tyr308 in beta(2)AR into Phe325 in beta(1)AR induce different conformations of the homologous Asn(6.55) inside the binding pockets of the two receptors, suggesting a possible origin of receptor specificity in agonist binding. The equilibrated structures of both receptors recover all of the previously suggested features of inactive GPCRs including formation of a salt bridge between the cytoplasmatic moieties of helices III and VI ("ionic lock") that is absent in the crystal structures.

  12. Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y4 Receptor Binding Pocket*

    PubMed Central

    Pedragosa-Badia, Xavier; Sliwoski, Gregory R.; Dong Nguyen, Elizabeth; Lindner, Diana; Stichel, Jan; Kaufmann, Kristian W.; Meiler, Jens; Beck-Sickinger, Annette G.

    2014-01-01

    Structural characterization of the human Y4 receptor (hY4R) interaction with human pancreatic polypeptide (hPP) is crucial, not only for understanding its biological function but also for testing treatment strategies for obesity that target this interaction. Here, the interaction of receptor mutants with pancreatic polypeptide analogs was studied through double-cycle mutagenesis. To guide mutagenesis and interpret results, a three-dimensional comparative model of the hY4R-hPP complex was constructed based on all available class A G protein-coupled receptor crystal structures and refined using experimental data. Our study reveals that residues of the hPP and the hY4R form a complex network consisting of ionic interactions, hydrophobic interactions, and hydrogen binding. Residues Tyr2.64, Asp2.68, Asn6.55, Asn7.32, and Phe7.35 of Y4R are found to be important in receptor activation by hPP. Specifically, Tyr2.64 interacts with Tyr27 of hPP through hydrophobic contacts. Asn7.32 is affected by modifications on position Arg33 of hPP, suggesting a hydrogen bond between these two residues. Likewise, we find that Phe7.35 is affected by modifications of hPP at positions 33 and 36, indicating interactions between these three amino acids. Taken together, we demonstrate that the top of transmembrane helix 2 (TM2) and the top of transmembrane helices 6 and 7 (TM6–TM7) form the core of the peptide binding pocket. These findings will contribute to the rational design of ligands that bind the receptor more effectively to produce an enhanced agonistic or antagonistic effect. PMID:24375409

  13. N-glycosylation of the β2 adrenergic receptor regulates receptor function by modulating dimerization.

    PubMed

    Li, Xiaona; Zhou, Mang; Huang, Wei; Yang, Huaiyu

    2017-07-01

    N-glycosylation is a common post-translational modification of G-protein-coupled receptors (GPCRs). However, it remains unknown how N-glycosylation affects GPCR signaling. β2 adrenergic receptor (β2 AR) has three N-glycosylation sites: Asn6, Asn15 at the N-terminus, and Asn187 at the second extracellular loop (ECL2). Here, we show that deletion of the N-glycan did not affect receptor expression and ligand binding. Deletion of the N-glycan at the N-terminus rather than Asn187 showed decreased effects on isoproterenol-promoted G-protein-dependent signaling, β-arrestin2 recruitment, and receptor internalization. Both N6Q and N15Q showed decreased receptor dimerization, while N187Q did not influence receptor dimerization. As decreased β2 AR homodimer accompanied with reduced efficiency for receptor function, we proposed that the N-glycosylation of β2 AR regulated receptor function by influencing receptor dimerization. To verify this hypothesis, we further paid attention to the residues at the dimerization interface. Studies of Lys60 and Glu338, two residues at the receptor dimerization interface, exhibited that the K60A/E338A showed decreased β2 AR dimerization and its effects on receptor signaling were similar to N6Q and N15Q, which further supported the importance of receptor dimerization for receptor function. This work provides new insights into the relationship among glycosylation, dimerization, and function of GPCRs. Peptide-N-glycosidase F (PNGase F, EC 3.2.2.11); endo-β-N-acetylglucosaminidase A (Endo-A, EC 3.2.1.96). © 2017 Federation of European Biochemical Societies.

  14. Prophylaxis and Treatment of Anthrax in Pregnant Women: A Systematic Review of Antibiotics

    PubMed Central

    Meaney-Delman, Dana; Rasmussen, Sonja A.; Beigi, Richard H.; Zotti, Marianne E.; Hutchings, Yalonda; Bower, William A.; Treadwell, Tracee A.; Jamieson, Denise J.

    2016-01-01

    Objective To review the safety and pharmacokinetics of antibiotics recommended for anthrax post-exposure prophylaxis and treatment in pregnant women. Data Sources Articles were identified in the PUBMED database from inception through December 2012 by searching the keywords ([“pregnancy]” and [generic antibiotic name]). Additionally, hand searches of references from REPROTOX, TERIS, review articles and Briggs’ Drugs in Pregnancy and Lactation were performed. Methods of Study Selection Articles included in the review contain primary data related to the safety and pharmacokinetics among pregnant women of five antibiotics recommended for anthrax post-exposure prophylaxis and treatment (ciprofloxacin, levofloxacin, moxifloxacin, doxycycline, amoxicillin), and of nine additional antibiotics recommended as part of the treatment regimen (penicillin, ampicillin, linezolid, clindamycin, meropenem, doripenem, rifampin, chloramphenicol, or vancomycin). Tabulation, Integration and Results The PUBMED search identified 3850 articles for review. Reference hand searching yielded nine additional articles. In total, 112 articles met the inclusion criteria. Conclusions Overall, safety and pharmacokinetic information is limited for these antibiotics. Although small increases in risks for certain anomalies have been observed with some antibiotics recommended for prophylaxis and treatment of anthrax, the absolute risk of these antibiotics appears low. Given the high morbidity and mortality associated with anthrax, antibiotics should be dosed appropriately to ensure that antibiotic levels can be achieved and sustained. Dosing adjustments may be necessary for the beta lactam antibiotics and the fluoroquinolones to achieve therapeutic levels in pregnant women. Data indicate that the beta lactam antibiotics, the fluoroquinolones, and, to a lesser extent, clindamycin enter the fetal compartment, an important consideration in the treatment of anthrax, as these antibiotics may provide

  15. Ramakrishna Mission initiative impact study: final report

    SciTech Connect

    Chaurey, A.

    2000-07-06

    This report has been prepared by the Tata Energy Research Institute (TERI) for the National Renewable Energy Laboratory. It presents the results of the evaluation and impact assessment of solar photovoltaic lighting systems in the region of Sunderbans, West Bengal, that were deployed by a reputable non-governmental organization (Ramakrishna Mission) under the auspices of the INDO-US collaborative project. The objectives of the study were to evaluate the solar photovoltaic systems for their impact on the individual households as well as on the community, to assess the effectiveness of the implementation and financial mechanisms, and to draw a long-term strategy for NREL's activities in Sunderbans based on case studies of similar interventions. Under the project, provision was made to supply 300 domestic lighting systems (DLS) based on 53-Wp module capacity to individual households and a few other systems such as for lighting, medical refrigeration, and pumping water to community centers. For this study, 152 households were surveyed, of which 29 had also been a part of earlier pre- and post-installation surveys, 47 had been a part of the earlier post-installation survey, and 76 were households that were surveyed for the first time. A set of 46, out of the total 152 households, was selected for evaluating the systems for their technical performance with respect to module output, condition of the battery, and daily energy consumption. Of the total 300 modules, 2 had been stolen, 9 out of the total 300 batteries needed to be replaced, and 10 out of the 300 charge controllers were non-functional. The statistics for the surveyed households indicate 32 luminaire-related faults (blackening or flickering of compact fluorescent lights) and 11 other faults related to fuses, switches, etc.

  16. [Quality assurance, audit and quality control of radiotherapy at radiology departments in Hungary].

    PubMed

    Esik, O; Németh, G; Erfán, J; Krommer, K; Kuhn, E; Mako, E; Mayer, A; Padányi, J; Péter, M; Pintér, T

    1995-11-05

    The first quality assurance, audit and control system in the Hungarian "'health" care industry" is described for the medical specialty of radiotherapy. The prerequisites of the elaboration of the programme were an exact knowledge of the current Hungarian infrastructural and staffing conditions, and the radiotherapeutic activities. The recommendations cover the 5 medical universities including the national institute (the Debrecen, Pécs, Semmelweis, Szent-Györgyk Albert Medical Universities, and Haynal Imre University of Health Sciences) and the 5 regional oncological centres in hospitals (Jósa András, Markusovszky, Petz Aladár, Szentpéteri kapu and Uzsoki Hospitals). The departmental functions (patient care, teaching-education, research work and scientific organizing activity) and the structure (organization, infrastructure, staffing conditions, etc.) are described first, followed by the therapeutic principles and clinical process (patient referral and selection, decision-making, priorities in therapy initiation, treatment preparation and execution, etc.). The informal daily/weekly quality assurance programme long applied in the routine patient care has been formalized and supplemented with a weekly audit conference. In the course of the medical audit, all relevant clinical data are reviewed and scored by an internal or an external expert (not participating directly in the treatment process), e.g. for the adequacy of the medical decision preparative process, conformation to the institutional treatment protocol, equipment selection, treatment planning, simulation and portal film, etc. If a major deviation is detected, an immediate correction is initiated; minor deviations need analysis and then preventive and correcting action. As concern the audit of the other activities of the departments, the important indicators and their minimally desirable level are defined. The final goal of the implementation of this programme is high-precision radiotherapy with the

  17. LDEF (Postflight), S1001 : Low-Temperature Heat Pipe Experiment Package (HEPP) for LDEF, Tray H01

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The postflight photograph of the Low Tem perature Heat Pipe Package (HEPP) power tray was taken in the SAEF II at KSC after an all up system checkout with interfacing experiments and removal of the tray from the LDEF. An outline of the experiment tray clamp blocks is clearly visible in the light brown stain on the experiment tray flanges. The Low Temperature Heat Pipe Package (HEPP) experiment occupies two 12 inch deep LDEF experiment trays connected with an inter-tray wiring harness. The HEPP Power tray, an end cor ner tray, occupies a location on the space end of the LDEF in tray location H01 and the HEPP Experiment tray, a peripheral tray, is located in the LDEF tray location F12. The power tray (H01) consist of four solar array panels, one nickel-cadmium (NiCd) battery, a Power System Electronics (PSE) unit, protective thermal blankets that line the tray interior and a thirty seven pound baseplate mounted on thermal isolators to provide a thermally stable mounting for the bat tery and the PSE. Thirteen strips of thin film thermal control materials, part of an experiment by NASA GSFC that consist of sixty-five samples located at three different LDEF tray locations (H01, F09 and F12), were attached to the experiment tray flanges with Kapton tape. The experi ment was assembled and mounted in the experiment tray with non-magnetic stainless steel fasten ers. The experiment hardware appears to be intact with no apparent changes other than stains along outer edges of the solar arrays. The light brown stains observed along the upper edges of the solar array mounting plates and around the outer edge of the baseplate in the flight photograph are not apparent in the postflight photo. The atomic oxygen experiment thin film strips appear to be in place with no apparent damage. The Kapton tape appears to be firmly adhered to the tray flanges in all thirteen locations.

  18. Safety of asthma and allergy medications in pregnancy.

    PubMed

    Chambers, Christina

    2006-02-01

    Given the unique nature of pregnancy with respect to obtaining safety data regarding medication exposures, developing comprehensive information on the wide variety of medications that might be of clinical benefit during pregnancy is a challenging and on-going task. For many of the most commonly used asthma and allergy medications that were covered in this article, there is at least limited human data are available. Even for relatively well-studied medications, there are many unanswered questions, and few studies exist that are large enough to rule out at least a doubling of risk for specific outcomes, particularly congenital anomalies. This challenge becomes even more daunting when evaluating risks of individual products is considered the optimal goal, as opposed to "lumping" all medication exposures within a class. All of these issues call for more human pregnancy data that are collected more efficiently so that the answers that clinicians and pregnant women need are available more readily. In the meantime, health care providers and pregnant women must work with the information that is available to evaluate the risks and benefits of a particular medication and alternative choices for treatment of asthma or allergy during pregnancy, while considering the potential for adverse effects if the woman with severe or uncontrolled asthma is under-treated. To assist in making a risk/benefit assessment, the clinician can draw on existing resources that provide systematic periodic review of new data on medications in pregnancy as it becomes available, and synthesize the entire body of data on a particular drug into concise summary statements. Two such resources are TERIS (TeratogenInformation System) [38] and Reprotox [39]; both on-line services are managed by experts in the field of teratology. An additional resource for clinicians and pregnant women is the Organization of Teratology Information Specialists [40], a network of risk-assessment counselors in the United States

  19. Human teratogens: update 2010.

    PubMed

    Holmes, Lewis B

    2011-01-01

    A wide variety of human teratogens have been identified. The characteristics of human teratogens can be used in the assessment of apparent "new" teratogens, when postulated. Information is available through online databases, such as TERIS and Reprotox, telephone-based counseling resources (e.g., Organization of Teratogen Information Systems [OTIS] and European Network Teratology Information Services [ENTIS]), reference books, annual meetings of the Teratology Society, and published articles. There are significant deficiencies in the information available: (1) lack of knowledge about the molecular and cellular basis for most teratogenic effects; (2) the inability to genetically identify more susceptible women before pregnancy; (3) little information is available on dermal and airborne exposures during pregnancy; and (4) most clinicians receive little, if any, training in the identification of or counseling for exposure to potential teratogens. There are many current dilemmas in counseling about exposures in pregnancy, including: (1) Is exposure to specific drugs, such as selected serotonin re-uptake inhibitors (SSRIs) and the inhibitors of tumor necrosis factor-alpha, teratogenic in the first trimester of pregnancy? (2) Are the increased risks of birth defects associated with assisted reproductive technology due, in part, to epigenetic effects? (3) What are the "safe" levels of exposure to the plasticizers phthalates during pregnancy? (4) How do we convince busy physicians, nurses, and pharmacists not to use the drug categories A, B, C, D, and X in counseling and to use more accurate sources? There is a need for a national advisory center for pregnancy registries to provide guidance when new registries are being developed.

  20. Thermodynamics, Kinetics and Structural Evolution of ε-LiVOPO 4 over Multiple Lithium Intercalation

    SciTech Connect

    Lin, Yuh-Chieh; Wen, Bohua; Wiaderek, Kamila M.; Sallis, Shawn; Liu, Hao; Lapidus, Saul H.; Borkiewicz, Olaf J.; Quackenbush, Nicholas F.; Chernova, Natasha A.; Karki, Khim; Omenya, Fredrick; Chupas, Peter J.; Piper, Louis F. J.; Whittingham, M. Stanley; Chapman, Karena W.; Ong, Shyue Ping

    2016-03-22

    ε -Li x VOPO 4 is a promising multi-electron cathode for rechargeable lithium-ion bat- teries that has an extremely high theoretical capacity of 318 mAh/g. In this w ork, we demonstrate the stable cycling of more than one Li in solid-state-syn thesized ε - LiVOPO 4 over more than 20 cycles for the first time. Using a combination of densit y functional theory (DFT) calculations, X-ray pair distribution funct ion (PDF) analy- sis and X-ray Absorption Near Edge Structure (XANES) measurements, we pre sent a comprehensive analysis of the thermodynamics, kinetics and stru ctural evolution of ε -Li x VOPO 4 over the entire lithiation range. We identify two intermediate ph ases at x = 1 . 5 and 1.75 in the low-voltage regime using DFT calculations, and the comput ed and electrochemically measured voltage profiles are in excellent agree ment. Operando PDF techniques show a reversible hysteretic change in the short ( < 2° A) V-O bond lengths coupled with an irreversible extension of the long V-O bond ( > 2.4 °A) dur- ing low-voltage cycling. These observations are confirmed with EXAFS spe ctra. We identify hydrogen intercalation from the electrolyte decomposition as a likely explana- tion for the ~ 2 . 4°A V-O bond and its irreversible extension. In terms of electronic conductivity, we find Li x VOPO 4 to be a large band gap insulator across the entire lithiation range, and calculated small polaron migration barriers are similar to those of the olivine LiMPO 4 cathodes. Finally, we demonstrate that ε -LiVOPO 4 is likely to be a one-dimensional diffuser using climbing-image nudged elastic ban d calculations. These results highlight the importance of nano-sizing and carbon coating in achieving good electrochemical performance in this material.

  1. Aerosol measurements at the Gual Pahari EUCAARI station: preliminary results from first year in-situ measurements

    NASA Astrophysics Data System (ADS)

    Hyvärinen, A.-P.; Lihavainen, H.; Komppula, M.; Panwar, T. S.; Sharma, V. P.; Hooda, R. K.; Viisanen, Y.

    2010-04-01

    The Finnish Meteorogical Institute (FMI), together with The Energy and Resources Institute of India (TERI), contributed to the The European Integrated project on Aerosol Cloud Climate and Air Quality Interactions, EUCAARI, by conducting aerosol measurements in Gual Pahari, India, from December 2007 to January 2010. This paper describes the station setup in detail for the first time and provides 1st year preliminary results from the aerosol in-situ measurements, which include PM and BC masses, aerosol size distribution from 4 nm to 10 μm, and the scattering and absorption coefficients. The seasonal variation of the aerosol characteristics was very distinct in Gual Pahari. The highest concentrations were observed during the winter and the lowest during the rainy season. The average PM10 concentration (at STP conditions) was 177 μg m-3 and the average PM2.5 concentration was 120 μg m-3. A high percentage (4-9%) of the PM10 mass consisted of BC which indicates anthropogenic influence. The percentage of BC was higher during the winter; and according to the diurnal pattern of the BC fraction, the peak occurred during anthropogenic activity times. Another important source of aerosol particles in the area was new particle formation. The nucleated particles grew rapidly reaching the Aitken and accumulation mode size, thus contributing considerably to the aerosol load. The rainy season decreased the average fraction of particle mass in the PM2.5 size range, i.e. of secondary origin. The other removal, or in this case, dilution mechanism was based on convective mixing and boundary layer evolution. This diluted the aerosol when sun radiation and the temperature was high, i.e. especially during the pre-monsoon day time. The lighter and smaller particles were more effectively diluted.

  2. Aerosol measurements at the Gual Pahari EUCAARI station: preliminary results from in-situ measurements

    NASA Astrophysics Data System (ADS)

    Hyvärinen, A.-P.; Lihavainen, H.; Komppula, M.; Panwar, T. S.; Sharma, V. P.; Hooda, R. K.; Viisanen, Y.

    2010-08-01

    The Finnish Meteorological Institute (FMI), together with The Energy and Resources Institute of India (TERI), contributed to the European Integrated project on Aerosol Cloud Climate and Air Quality Interactions, EUCAARI, by conducting aerosol measurements in Gual Pahari, India, from December 2007 to January 2010. This paper describes the station setup in detail for the first time and provides results from the aerosol in-situ measurements, which include PM and BCe masses, aerosol size distribution from 4 nm to 10 μm, and the scattering and absorption coefficients. The seasonal variation of the aerosol characteristics was very distinct in Gual Pahari. The highest concentrations were observed during the winter and the lowest during the rainy season. The average PM10 concentration (at STP conditions) was 216 μgm-3 and the average PM2.5 concentration was 126 μgm-3. A high percentage (4-9%) of the PM10 mass consisted of BCe which indicates anthropogenic influence. The percentage of BCe was higher during the winter; and according to the diurnal pattern of the BCe fraction, the peak occurred during active traffic hours. Another important source of aerosol particles in the area was new particle formation. The nucleated particles grew rapidly reaching the Aitken and accumulation mode size, thus contributing considerably to the aerosol load. The rainy season decreased the average fraction of particle mass in the PM2.5 size range, i.e. of secondary origin. The other mechanism decreasing the surface concentrations was based on convective mixing and boundary layer evolution. This diluted the aerosol when sun radiation and the temperature was high, i.e. especially during the pre-monsoon day time. The lighter and smaller particles were more effectively diluted.

  3. From numbers to letters: feedback regularization in visual word recognition.

    PubMed

    Molinaro, Nicola; Duñabeitia, Jon Andoni; Marìn-Gutièrrez, Alejandro; Carreiras, Manuel

    2010-04-01

    Word reading in alphabetic languages involves letter identification, independently of the format in which these letters are written. This process of letter 'regularization' is sensitive to word context, leading to the recognition of a word even when numbers that resemble letters are inserted among other real letters (e.g., M4TERI4L). The present study investigates the electrophysiological correlates of number-to-letter regularization by means of the masked priming paradigm: target words (MATERIAL) were preceded by fully alphabetic primes (MATERIAL), primes with letter-like numbers (M4T3R14L), or primes with unrelated numbers (M7T6R28L). ERPs revealed three subsequent effects. Around 150 ms the unrelated numbers condition elicited a positive effect, compared to the other two conditions, in the occipital electrodes. Then, target words preceded by primes with numbers elicited a more negative N200 in the same electrodes compared to the fully alphabetic condition. Finally, both alphabetic primes and letter-like numbers elicited a posterior positive component peaking around 260 ms compared to unrelated numbers. Source analysis for each electrophysiological effect revealed a similar early increase of activity in the left occipito-temporal pathway for alphabetic primes and primes with letter-like numbers. Around 200 ms, the orthographic interference due to the numerical values correlated with an increase of activity in parietal areas; finally, a recursive effect in the left occipital cortex was found, reflecting abstract letter activation. These results indicate that direct feedback interaction from word units strongly influences the activation of the letter units at a format-independent abstract level.

  4. The effects of a multi-component dyadic intervention on the psychological distress of family caregivers providing care to people with dementia: a randomized controlled trial.

    PubMed

    Prick, Anna-Eva; de Lange, Jacomine; Twisk, Jos; Pot, Anne Margriet

    2015-12-01

    Earlier research showed that multi-component dyadic interventions - including a combination of intervention strategies and addressing both the person with dementia and caregiver - have a beneficial impact on the mental and physical health of people with dementia and their family caregivers. A randomized controlled trial (RCT) of a multi-component dyadic intervention, which is a translated and adapted version of an intervention that has been shown to be effective in the US by Teri et al. (2003), was performed. The effects on caregivers' mood (primary outcome), burden, general health, and salivary cortisol levels (secondary outcomes) were studied. Community-dwelling people with dementia and their family caregivers (N = 111 dyads) were randomly assigned. The experimental group received eight home visits during three months, combining physical exercise and support (psycho-education, communication skills training, and planning of pleasant activities). Both the physical exercise and support component were directed at both the person with dementia and the caregiver. The comparison group received monthly information bulletins and phone calls. There were three measurements at baseline (prior to the intervention), at three months, and at six months into the intervention. Data were analyzed with Generalized Estimating Equations (GEE) based on an intention-to-treat analysis of all available data. All analyses showed no benefits of the intervention over time on any of the outcomes. The negative results might be explained by the translation and adaptation of the intervention that has been shown to be effective in the US: the intervention was shortened and did not include cognitive reframing. However, only the health effects on people with dementia and not on caregivers were studied in the US. Several other factors might also have played a role, which are important for future studies to take into account. These are: the usual health care in the country or region of implementation

  5. Environmental issues of petroleum exploration and production: Introduction

    USGS Publications Warehouse

    Kharaka, Yousif K.; Dorsey, Nancy S.

    2005-01-01

    of several acres per well, can also arise from related activities such as site clearance, construction of roads, tank bat- teries, brine pits and pipelines, and other land modifications nec- essary for the drilling of exploration and production wells and construction of production facilities. The cumulative impacts from these operations are high, because a total of about 3.5 million oil. 

  6. LDEF (Postflight), S1001 : Low-Temperature Heat Pipe Experiment Package (HEPP) for LDEF, Tray H01

    NASA Technical Reports Server (NTRS)

    1990-01-01

    LDEF (Postflight), S1001 : Low-Temperature Heat Pipe Experiment Package (HEPP) for LDEF, Tray H01 The post landing photograph of the Low Tempera ture Heat Pipe Package (HEPP) experiment was taken from the Orbiter's cargo bay access hatch during post landing operations to prepare the Orbiter for the ferry flight from the Dryden Flight Research Center to the Kennedy Space Center. The white paint dots on the center clamp blocks of the experiment trays right flange and upperer flange appear to be discolored. The discoloration diminishes as as the distance from the vent area of the thermal shields increases. The right and upper tray flanges also appear to be discolored. Finger prints are visible on the thermal panels in the vicinity of the panel mounting fasteners. The Low Temperature Heat Pipe Package (HEPP) experiment occupies two 12 inch deep LDEF experiment trays connected with an inter-tray wiring harness. The HEPP Power tray, an end cor ner tray, occupies a location on the space end of the LDEF in tray location H01 and the HEPP Experiment tray, a peripheral tray, is located in the LDEF tray location F12. The power tray (H01) consist of four solar array panels, one nickel-cadmium (NiCd) battery, a Power System Electronics (PSE) unit, protective thermal blankets that line the tray interior and a thirty seven pound baseplate mounted on thermal isolators to provide a thermally stable mounting for the bat tery and the PSE.. Thirteen strips of thin film thermal control materials, part of an experiment by NASA GSFC that consist of sixty-five samples located at three different LDEF tray locations (H01, F09 and F12), were attached to the experiment tray flanges with Kapton tape. The experi ment was assembled and mounted in the experiment tray with non-magnetic stainless steel fasten ers. The experiment hardware appears to be intact with no apparent changes other than stains along outer edges of the solar arrays. Light brown stains are visible along the upper edges of the

  7. LDEF (Flight), S1001 : Low-Temperature Heat Pipe Experiment Package (HEPP) for LDEF, Tray H01

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The flight photograph of the Low Temperature Heat Pipe Package (HEPP) experiment was taken while the LDEF was attached to the Orbiter's RMS arm prior to berthing in the Orbiter's cargo bay. The white paint dots on the center clamp blocks of the experiment trays right flange and lower flange appear to be discolored. The discolor ation diminishes as as the distance from the vent area of the thermal shields increases. The right and lower tray flanges also appear to be discolored. Finger prints are visible on the thermal panels in the vicinity of the panel mounting fasteners. The Low Temperature Heat Pipe Package (HEPP) experiment occupies two 12 inch deep LDEF experiment trays connected with an inter-tray wiring harness. The HEPP Power tray, an end cor ner tray, occupies a location on the space end of the LDEF in tray location H01 and the HEPP Experiment tray, a peripheral tray, is located in the LDEF tray location F12. The power tray (H01) consist of four solar array panels, one nickel-cadmium (NiCd) battery, a Power System Electronics (PSE) unit, protective thermal blankets that line the tray interior and a thirty seven pound baseplate mounted on thermal isolators to provide a thermally stable mounting for the bat tery and the PSE. Thirteen strips of thin film thermal control materials, part of an experiment by NASA GSFC that consist of sixty-five samples located at three different LDEF tray locations (H01, F09 and F12), were attached to the experiment tray flanges with Kapton tape. The experi ment was assembled and mounted in the experiment tray with non-magnetic stainless steel fasten ers. The experiment hardware appears to be intact with no apparent changes other than stains along outer edges of the solar arrays. Light brown stains are visible along the upper edges of the solar array mounting plates with faint traces of a lighter colored stain around the outer edge of the base plate. The atomic oxygen experiment thin film strips appear to be in place with no

  8. Realities of weather extremes on daily life in urban India - How quantified impacts infer sensible adaptation options

    NASA Astrophysics Data System (ADS)

    Reckien, D.

    2012-12-01

    when resources are scarce. 1 Parry ML, Canziani OF, Palutikof JP, van der Linden PJ, Hanson CE (eds) (2007) Contribution of Working Group II to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge University Press, Cambridge New York. 2 TERI (2007) Adaptation to Climate Change in the context of Sustainable Development. Background Paper to the conference ''Climate Change and Sustainable Development: An international workshop to strengthen research and understanding'', 7-8 April 2006, The Energy and Resources Institute, New Delhi.

  9. Driving factors of aerosol concentration changes in the foothills of Central Himalayas

    NASA Astrophysics Data System (ADS)

    Kivekäs, Niku; Hooda, Rakesh; Hyvärinen, Antti-Pekka; Collaud-Coen, Martine; O'Connor, Ewan; Pietikäinen, Joni-Pekka; Backman, John; Vakkari, Ville; Lihavainen, Heikki

    2017-04-01

    the aerosol particles from the air. Then the aerosol concentration started to accumulate, showing a lower peak in the fall and a higher one in the pre-monsoon season. These peaks coincide with the crop residue burning seasons and also with the sand storm season. The winter moths typically showed somewhat lower values, which could be explained by the lower mixing layer bringing less polluted air to the site. Apart for a negative trend in PM, no statistically significant trends were found for any of the aerosol parameters, and the observed inter-annual aerosol patterns were in general different from that of the emission inventories. There were deviations from the typical seasonal pattern of aerosols, but we were able to link each of those deviations to anomalous weather patterns such as weak or late monsoon. In conclusion we can state that the diurnal and seasonal meteorological patterns govern the aerosol concentrations at Mukteshwar so strongly that they hide other possible factors affecting the aerosol properties. This work was supported by the Ministry of Foreign Affairs of Finland, and by FMI - TERI bilateral collaboration.

  10. Journal abstracts from current research in the field of child and adolescent mental health.

    PubMed

    2009-12-01

    Debate RD, Kelley PG, Zwald M, Huberty J & Zhang Y (2009) Changes in psychosocial factors and physical activity frequency among third- to eighth-grade girls who participated in a developmentally focused youth sport program: A preliminary study. Journal of School Health 79(10): 474-484 Boyce JC, Mueller NB, Hogan-Watts M & Luke Douglas A (2009) Evaluating the strength of school tobacco policies: The development of a practical rating system. Journal of School Health 79(10): 495-504 Craine JL, Tanaka Teri A, Nishina A & Conger KJ (2009) Understanding adolescent delinquency: The role of older siblings' delinquency and popularity with peers. Merrill-Palmer Quarterly 55(4): 436-453 Rosales FJ, Reznick JS & Zeisel SH (2009) Understanding the role of nutrition in the rain and behavioural development of toddlers and pre-school children: Identifying methodological barriers. Nutritional Neuroscience 12(5): 190-202 Clemmens DA (2009) The Significance of motherhood for adolescents whose mothers have breast cancer. Oncology Nursing Forum 36(5): 571-577 Archambault I, Janosz M, Morizot J & Pagani L (2009) Adolescent behavioural, affective, and cognitive engagement in school: Relationship to dropout. Journal of School Health 79(9): 408-415 Denison JA, McCauley AP, Dunnett-Dagg WA, Lungu N & Sweat MD (2009) HIV testing among adolescents in Ndola, Zambia: How individual, relational, and environmental factors relate to demand. AIDS Education & Prevention 21(4): 314-324 Pollock JA & Halkitis PN (2009) Environmental factors in relation to unprotected sexual behaviour among gay, bisexual and other MSM. AIDS Education & Prevention 21(4): 340-355 Nippold MA, Mansfield TC, Billow JL & Tomblin JB (2009) Syntactic development in adolescents with a history of language impairments: A follow-up investigation. American Journal of Speech-Language Pathology 18(3): 241-251 Sharaf AY, Thompson EA & Walsh E (2009) Protective effects of self-esteem and family support on suicide risk behaviours among

  11. Source quantification of size and season resolved aerosols in a semi-urban area of Indo-Gangetic plain, India

    NASA Astrophysics Data System (ADS)

    Hooda, R. K.; Hyvärinen, A.; Gilardoni, S.; Sharma, V.; Vestenius, M.; Kerminen, V.; Vignati, E.; Kulmala, M. T.; Lihavainen, H.

    2012-12-01

    This study describes a one year measurements of size-segregated aerosols at a semi-urban site in Indo-Gangetic plain (IGP), India, South Asia with focus on source quantification applied to organic and inorganic chemical species data using Positive Matrix Factorization (PMF), trajectory analysis and conditional probability function (CPF) methods. The campaign was planned in the framework of the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. In light of the above, Finnish Meteorological Institute (FMI), The Energy and Resources Institute (TERI) and Joint Research Centre (JRC) conducted aerosol mass measurements in Gual Pahari, India from April 2008 to March 2009. The average mass concentrations of fine (PM2.5) and coarse (PM2.5-10) aerosols are higher during the postmonsoon (October-November) and winter (December- February) compared to that during the summer season (March-May). Fine and coarse fraction concentrations observed are higher during the post-monsoon & winter months due to low and stable boundary layer. Concentrations decrease in March-June due to increasing temperatures and a higher boundary layer. The lowest concentrations are during the rainy months (June to August/Sept) due to wet removal. OC and EC fraction is higher in PM2.5. EC in in PM2.5 is 9%, and in PM2.5-10 size EC is 2%. OC contribution is about 36% of fine aerosol mass. High OC could be attributed to enhanced combustion sources and the meteorological conditions during winter period. High OC to EC ratio during postmonsoon and winter also supports higher secondary organic aerosol (SOA) formation in these seasons. Secondary organic carbon (SOC) calculated is 42% of the annual average of total OC in coarse fraction. SOC to total OC is highest in postmonsoon (53%), winter (34%) and followed by 29% in summer and monsoon seasons. 24-hr speciated fine and coarse aerosols annual data was used for source identification and quantification studies with

  12. Stress field modelling from digital geological map data

    NASA Astrophysics Data System (ADS)

    Albert, Gáspár; Barancsuk, Ádám; Szentpéteri, Krisztián

    2016-04-01

    calculated from the fracture criterion. The calculation includes the gravitational acceleration, the average density of rocks and the experimental 60 degree of the fracture angle from the normal of the fault plane. This way, the stress tensors are calculated as absolute pressure values per square meters on both sides of the faults. If the stress from the overburden is greater than 1 bar (i.e. the faults are buried), a confined compression would be present. Modelling this state of stress may result a confusing pattern of vectors, because in a confined position the horizontal stress vectors may point towards structures primarily associated with extension. To step over this, and to highlight the variability in the stress-field, the model calculates the vectors directly from the differential stress (practically subtracting the minimum principal stress from the critical stress). The result of the modelling is a vector map, which theoretically represents the minimum tectonic pressure in the moment, when the rock body breaks from an initial state. This map - together with the original fault-map - is suitable for determining those areas where unrevealed tectonic, sedimentary and lithological structures are possibly present (e.g. faults, sub-basins and intrusions). With modelling different deformational phases on the same area, change of the stress vectors can be detected which reveals not only the varying directions of the principal stresses, but the tectonic-driven sedimentation patterns too. The decrease of necessary critical stress in the case of a possible reactivation of a fault in subsequent deformation phase can be managed with the down-ranking of the concerning structural elements. Reference: Albert G., Ungvári ZS., Szentpéteri K. 2014: Modeling the present day stress field of the Pannonian Basin from neotectonic maps - In: Beqiraj A, Ionescu C, Christofides G, Uta A, Beqiraj Goga E, Marku S (eds.) Proceedings XX Congress of the Carpathian-Balkan Geological Association

  13. New developments at Hunveyor and Husar space probe model constructions in Hungarian Universities and Colleges: status report of 2008

    NASA Astrophysics Data System (ADS)

    Hegzi, S.; Bérczi, Sz.; Hudoba, Gy.; Magyar, I.; Lang, A.; Istenes, Z.; Weidinger, T.; Tepliczky, I.; Varga, T.; Hargitai, H.

    2008-09-01

    Society developed the last Hunveyor system. It was a meteorological station with 14 measurements. It represents a halfway Hunveyor, because of the building together of the instruments can be studied in this system. It was transported by the Crew 71 to the MDRS and two weeks of measurements were carried out in Utah, during 2008 April (with Husar-2d field work, too). Summary Several new developments of the Hunveyor-Husar university robot system were shown to mark the intensity of interest of students to the preparations to the field work research in planetary geology by building robotics and use them in field works. References: [1] Hargitai, H. (2004): 35th LPSC, #1078. LPI, Houston; [2] Bérczi, Sz.; Fabriczy, A.; Hargitai, H.; Hegyi, S.; Illés, E.; Kabai, S.; Kovács, Zs.; Kereszturi, A.; Opitz, A.; Sik, A.; 34th LPSC, #1305. LPI, Houston; [3] Bérczi Sz. Hargitai H., Kereszturi Á., Sik A. (2001, 2005): [4] Roskó, F.; Diósy, T.; Bérczi, Sz.; Fabriczy, A.; Cech, V.; Hegyi, S. (2000): 31st LPSC, #1572. LPI, Houston; [5] Bérczi Sz., Hegyi S., Kovács Zs., Fabriczy A., Földi T., Keresztesi M., Cech V., Drommer B., Gránicz K., Hevesi L., Borbola T., Tóth Sz., Németh I., Horváth Cs., Diósy T., Kovács B., Bordás F., Köllõ Z., Roskó F., Balogh Zs., Koris A., Imrek Gy. (2001, 2002): [6] Bérczi, Sz.; Diósy, T.; Tóth, Sz.; Hegyi, S.; Imrek, Gy.; Kovács, Zs.; Cech, V.; Müller-Bodó, E.; Roskó, F.; Szentpétery, L.; Hudoba, Gy. (2002): 33rd LPSC, #1496. LPI, Houston; [7] Hudoba, Gy.; Kovács, Zs. I.; Pintér, A.; Földi, T.; Hegyi, S.; Tóth, Sz.; Roskó, F.; Bérczi, Sz. (2004): 35th LPSC, #1572. LPI, Houston; [8] Gimesi, L.; Béres, Cs. Z.; Bérczi, Sz.; Hegyi, S.; Cech, V. (2004): 35th LPSC, #1140; [9] Hegyi, S.; Drommer, B.; Hegyi, A.; Biró, T.; Kókány, A.; Hudoba, Gy.; Bérczi, Sz. (2006): 37th LPSC, #1136. LPI, Houston; [10] Bérczi, Sz.; Gál-Sólymos, K.; Gucsik, A.; Hargitai, H.; Józsa, S.; Szakmány, Gy.; Kubovics, I.; Puskás, Z. (2006): 37th LPSC