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  1. Letter: Photodistributed reticulated hyperpigmentation related to diltiazem.

    PubMed

    Jaka, Ane; López-Pestaña, Arantxa; Tuneu, Anna; Lobo, Carmen; López-Núñez, María; Ormaechea, Nerea

    2011-07-15

    Diltiazem is a calcium channel blocking agent used for the treatment of hypertension. Cutaneous adverse effects are uncommon. The most frequently reported are itching, urticaria, and maculopapular eruption. A peculiar, cutaneous photodistributed reticulated hyperpigmentation secondary to diltiazem has been recently reported. A 66-year-old white woman with a 2 year history of pruritic hyperpigmented lesions on her face was seen in the clinic. Past medical history was remarkable for hypertension, which had been treated with diltiazem. Physical examination showed slate-gray to brown reticulated hyperpigmentation in the photo-exposed areas of the face and neck. Histological examination revealed interface dermatitis with liquefactive degeneration of the basal layer, necrotic keratinocytes, lymphocytic inflammatory infiltrate, and melanophages in the superficial dermis. A diagnosis of diltiazem-induced hyperpigmentation was established and diltiazem was stopped. Gradual resolution of the hyperpigmentation was observed over the following months. Although diltiazem has been marketed for over 20 years, the first cases of this particular type of reticulated hyperpigmentation were described in 2001. Since then, to our knowledge, only 17 cases have been reported in the literature. In all cases, cutaneous lesions appeared at least 6 months after this treatment had been started. Hyperpigmentation was controlled by means of photoprotection and discontinuation of diltiazem. Diltiazem can produce a characteristic lichenoid dermatitis with reticulated hyperpigmentation on sun-exposed areas.

  2. Diltiazem

    MedlinePlus

    ... to the heart.High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, ...

  3. Antitussive effect of diltiazem in experimental conditions.

    PubMed

    Franova, S; Nosalova, G

    2004-01-01

    Cough is the most important defence reflex of the airways. Little information exists about participation of the ion channels in the mechanism of the cough reflex. The aim of the study was to investigate the effect of diltiazem administration on the sensitivity of the mechanically induced cough reflex in experimental conditions. Mechanical stimulation of the laryngopharyngeal and tracheobronchial area of the airways in non-anaesthetized cats was used in this experiment. The number of cough efforts, and the frequency and intensity of the cough attack were utilized as evaluated parameters. Perorally administered diltiazem (30 mg/kg b.w.) caused a statistically significant decrease of measured cough parameters. Cough - suppressing activity of diltiazem was lower than codeine, but higher than dropropizine and prenoxdiazine. Experimental results showed antitussive activity of the calcium-channel blocker diltiazem and suggested the role of voltage-gated calcium channels of type L in mechanism of the cough reflex. (Fig. 4, Ref. 15.).

  4. [Attempted suicide with sustained release diltiazem].

    PubMed

    Quispel, R; Baur, H J

    2001-05-12

    A 15-year-old woman was admitted to the intensive care unit after intentional auto-intoxication with 10 tablets of 200 mg diltiazem sustained release. She developed hypotension and became oliguric. This was followed by metabolic acidosis. Maximum plasma lactate concentration was 10 mmol/l and the highest measured plasma diltiazem level was 500 micrograms/l. The occurrence of pulmonary oedema due to adult respiratory distress syndrome (ARDS) was striking and the patient required mechanical ventilation for a period of three days as a result of this. After five days in the intensive care unit, she was transferred to a psychiatric hospital in a good physical condition. Sustained release diltiazem intoxications have previously been described on five occasions.

  5. The peripheral vascular effects of diltiazem--dose-response characteristics.

    PubMed Central

    Finch, M B; Johnston, G D

    1985-01-01

    The acute effects of increasing doses of diltiazem on peripheral blood flow were observed in six subjects. Each subject received, in random order, a single oral dose of placebo or diltiazem 60, 120 or 180 mg. Supine heart rate, blood pressure, skin temperature, digital systolic pressure, forearm and digital blood flow were recorded before and at 1, 2, 3, 4 and 6 h post-dosing. Plasma diltiazem concentrations were measured at each time interval and at 12 and 24 h after the 120 mg dose. At doses of 120 and 180 mg, diltiazem significantly increased digital blood flow at 1, 2, 3, 4 and 6 h post-dosing and forearm blood flow at 2 and 3 h following 180 mg and 3 h following 120 mg. No correlation was observed between plasma diltiazem concentration and changes in peripheral blood flow. PMID:4074614

  6. Los ojos de la NASA sobre la Tierra

    NASA Image and Video Library

    La NASA cuenta con más de una decena de satélites que estudian la Tierra. Conoce la información que recaban los satélites, junto con Gilberto Colón, asistente especial del subdirector del Centro de...

  7. Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.

    PubMed

    Kurokawa, Takaya; Fukami, Tatsuki; Nakajima, Miki

    2015-08-01

    Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem after oral dosing with diltiazem in rats was sevenfold higher than in humans, the molecular mechanisms underlying this species difference remain to be clarified. In the present study, we compared the diltiazem deacetylase activity in liver, intestinal, renal, and pulmonary microsome preparations of human and experimental animal tissues to identify the specific deacetylase enzyme(s) involved in deacetylation. Diltiazem deacetylase activity was detected in rat liver and small intestine microsome preparations, but not in those from human, monkey, dog, and mouse tissues. Further purification of rat liver microsome (RLM) proteins identified four carboxylesterase (Ces) enzymes (Ces1d, Ces1e, Ces1f, and Ces2a) as potential candidate deacetylases. On the basis of their tissue distribution, the Ces2a enzyme was considered to be the enzyme that was responsible for diltiazem deacetylation. Furthermore, recombinant rat Ces2a expressed in Sf21 cells displayed efficient diltiazem deacetylase activity with similar Km values as RLM. In addition, the inhibitory characteristics of various chemical inhibitors were similar between recombinant rat Ces2a and RLM. In conclusion, we determined that only rat tissues were able to catalyze diltiazem deacetylation. The characterization of Ces enzymes in animal species, as undertaken in this study, will prove useful to predict the species-specific pharmacokinetics differences between the in vivo models used for drug development. Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.

  8. Interactions between diltiazem and inhalation anaesthetics in the isolated heart.

    PubMed

    Carceles, M D; Miralles, F S; Laorden, M L; Hernandez, J

    1989-09-01

    It has been postulated that inhalation anaesthetics may interfere with calcium movement across cell membranes. We have evaluated the interaction between diltiazem and the inhalation anaesthetics halothane and isoflurane on sinus automaticity in the isolated right atrium (SAIRA). Isoflurane significantly reduced atrial rate at all concentrations tested. However, halothane produced only a small but significant decrease at the higher concentrations used (1-2 v/v%). Diltiazem modified the maximal negative chronotropic response to inhalation anaesthetics. Maximum depression of SAIRA was significantly greater in the presence of two different doses of diltiazem compared with exposure to halothane and isoflurane alone. These results suggest that inhalation anaesthetics may block the influx of extracellular calcium through voltage-dependent calcium channels inhibited by diltiazem.

  9. Effect of diltiazem on exercise capacity after heart transplantation.

    PubMed

    Varnado, Sara; Peled-Potashnik, Yael; Huntsberry, Ashley; Lowes, Brian D; Zolty, Ronald; Burdorf, Adam; Lyden, Elizabeth R; Moulton, Michael J; Um, John Y; Raichlin, Eugenia

    2017-08-01

    Sinus tachycardia (ST) is common after heart transplantation (HTx). The aim of the study was to evaluate the effect of diltiazem treatment during the first year after HTx on heart rate (HR), cardiac allograft function, and exercise capacity. From the total cohort, 25 HTx recipients started diltiazem treatment 4±2 weeks after HTx and continued it for at least 1 year (diltiazem group). Each study case was matched to a control. All patients underwent hemodynamic assessment and cardiopulmonary exercise test (CPET) at 1 year after HTx. HR decreased in the diltiazem group from 99±11 bpm to 94±7 bpm (P=.03) and did not change in the controls (98±11 bpm vs 100±13 bpm, P=.14). The difference between the groups at 1 year after HTx was significant (P=.04). In the diltiazem group left ventricular (LV), stroke volume and ejection fraction increased (48±16 vs 55±17 mL, P=.02, and 60%±10% vs 62%±12% P=.03, respectively) but did not differ from controls. E/E' decreased (10.7±2.7 vs 7.3±1.9, P=.003) while cardiac index was higher (3.5±0.8 vs 3.1±0.5; P=.05) in the diltiazem group at 1-year follow-up. The absolute peak VO2 (21±4 vs 18±6 mL/kg/min; P=.05) and normalized peak VO2 (73%±17% vs 58%±14%; P=.004) were significantly higher in the diltiazem group. This study showed that diltiazem treatment reduces ST, may improve cardiac allograft function and exercise tolerance during the first year after HTx. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Inhibitory effects of diltiazem on vasoconstrictor responses in the cat.

    PubMed

    Kadowitz, P J; Armstead, W M; Roland, P Y; Hyman, A L; Lippton, H L

    1988-01-01

    The effect of diltiazem on vasoconstrictor responses was investigated in the feline mesenteric vascular bed under conditions of controlled blood flow. Diltiazem inhibited vasoconstrictor responses to sympathetic nerve stimulation, tyramine and norepinephrine suggesting that responses to both nerve-released and exogenous norepinephrine are dependent in part on an extracellular source of calcium. The calcium entry antagonist inhibited vasoconstrictor responses to alpha 1 and to alpha 2 adrenoceptor agonists over a wide range of concentration. Diltiazem also inhibited mesenteric vasoconstrictor responses to angiotensin II, vasopressin, prostaglandin F2 alpha and KCl. The inhibitor effects of diltiazem on vasoconstrictor responses to nerve stimulation and the pressor agents were reversible, and all responses returned to control value 30 to 45 min after the infusion of the calcium entry antagonist. The present data suggest that the inhibitory effects of diltiazem on responses to sympathetic nerve stimulation are postjunctional in nature, as responses to nerve-released and exogenous norepinephrine and nonadrenergic pressor agents are reduced to a similar extent. The present results suggest that vasoconstrictor responses to neuronally released and exogenous norepinephrine, as well as agents which activate membrane receptors or depolarize vascular smooth muscle in the feline mesenteric vascular bed, are dependent in part on an extracellular source of calcium. The inhibitory effects of diltiazem on vasoconstrictor responses to sympathetic nerve stimulation and pressor hormones may be relevant to the antihypertensive actions of this calcium entry antagonist.

  11. Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation.

    PubMed

    Altman, R; Scazziota, A; Dujovne, C

    1988-09-01

    Platelet aggregation in vivo occurs through the combined effects of many agonists. Aspirin inhibits platelet aggregation but its antiaggregate effects can be overcome by the synergistic action of sodium arachidonate (AA) plus platelet activating factor (PAF). We tested the effect of a calcium entry-blocking agent, diltiazem, on AA-PAF-induced platelet aggregation in platelet-rich plasma from seven healthy volunteers. The studies were done before and after aspirin (100 mg/day) administration for 7 to 10 days. Stimulation of platelet was done in vitro by AA, PAF, or both. Before aspirin treatment, diltiazem (2 micrograms/ml) added in vitro to the platelet-rich plasma inhibited platelet aggregation induced by AA (0.75 mmol/L) by 50%. When PAF was used the inhibition of aggregation was obtained at a lower concentration of diltiazem (0.4 to 1 microgram/ml). After aspirin treatment, AA-induced aggregation was inhibited, and PAF alone (30 nmol/L) produced a first-wave aggregation followed by complete disaggregation. When AA and PAF were added together a full aggregation of postaspirin treatment platelets was obtained. Diltiazem added in vitro at the clinically attainable concentration of 0.1 microgram/ml produced a complete inhibition of this AA-PAF synergism on platelet aggregation. These results suggest that administration of a combination of low-dose aspirin and diltiazem may be of greater benefit than aspirin alone for prophylaxis of cardiovascular diseases where platelets are involved in the pathogenesis.

  12. Diltiazem and verapamil preferentially block inactivated cardiac calcium channels.

    PubMed

    Kanaya, S; Arlock, P; Katzung, B G; Hondeghem, L M

    1983-02-01

    Diltiazem has been proposed to act by blocking calcium channels of cardiac and smooth muscle since it has pharmacological [12-14] and clinical [10] effects that resemble those of verapamil, an agent that has been shown to block these channels [3]. However, block of the slow inward current by diltiazem has not been directly demonstrated. In fact, it has been suggested that diltiazem has an entirely different mechanism of action [7]. We therefore studied the blocking effects of diltiazem and verapamil on cardiac calcium channels by measuring the slow inward current in voltage-clamped ferret myocardium. Both drugs blocked the slow inward current in a use-dependent fashion, i.e. the block was enhanced by increased frequency of activating clamps and by more positive holding potentials. However, we found that short single activating clamps resulted in minimal block, whereas prolonging the clamp step progressively enhanced the blockade. Thus, a single long clamp caused as much blockade as a train of shorter pulses. These results demonstrate that diltiazem and verapamil block the slow inward current by binding to calcium channels in a state-dependent fashion, i.e. inactivated channels have a high affinity for the drugs, while rested and open channels have a lower affinity.

  13. Impact of Diltiazem Alone versus Diltiazem with Nitrate on Five-Year Clinical Outcomes in Patients with Significant Coronary Artery Spasm

    PubMed Central

    Park, Taeshik; Park, Ji Young; Choi, Byoung Geol; Choi, Se Yeon; Byun, Jae Kyeong; Park, Sang-Ho; Park, Eun Jin; Choi, Jah Yeon; Park, Sung Hun; Lee, Jae Joong; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Kim, Jin Won; Kim, Eung Ju; Park, Chang Gyu; Oh, Dong Joo

    2017-01-01

    Purpose Calcium channel blockers diltiazem and nitrate have been used as selective coronary vasodilators for patients with significant coronary artery spasm (CAS). However, no study has compared the efficacy of diltiazem alone versus diltiazem with nitrate for long-term clinical outcomes in patients with CAS. Materials and Methods A total of 2741 consecutive patients without significant coronary artery disease with positive CAS by acetylcholine (Ach) provocation test between November 2004 and May 2014 were enrolled. Significant CAS was defined as a narrowing of >70% by incremental intracoronary injection of 20, 50, and 100 µg of Ach into the left coronary artery. Patients were assigned to either the diltiazem group (n=842) or the dual group (diltiazem with nitrate, n=1899) at physician discretion. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM analysis, two well-balanced groups (811 pairs, n=1622, C-statistic=0.708) were generated. Results At 5 years, there were similar incidences in primary endpoints, including mortality, myocardial infarction, revascularization, and recurrent angina requiring repeat coronary angiography between the two groups. Diltiazem alone was not an independent predictor for major adverse cardiovascular events or recurrent angina requiring repeat coronary angiography. Conclusion Despite the expected improvement of endothelial function and the relief of CAS, the combination of diltiazem and nitrate treatment was not superior to diltiazem alone in reducing mortality and cardiovascular events up to 5 years in patients with significant CAS. PMID:27873500

  14. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol.

    PubMed

    Freitas, Felipe; Estato, Vanessa; Lessa, Marcos A; Tibiriçá, Eduardo

    2015-02-01

    Cardiac microvascular rarefaction appears to be involved in hyperthyroidism-induced left ventricular hypertrophy and dysfunction. We investigated the effects of losartan, an AT1 receptor antagonist; diltiazem, a calcium channel blocker; and propranolol, a β-adrenergic receptor antagonist, on cardiac function and structural microcirculatory cardiac alterations in an experimental model of l-thyroxin-induced hyperthyroidism in rats. Hyperthyroidism (HYPER) was induced by intraperitoneal injections of l-thyroxin for 35 days (600 μg/kg/day; n = 32). The euthyroid group was treated with distilled water (EUT + VEH; n = 8). On the 14th day, the HYPER group was divided into four groups that received an oral treatment for 21 days with saline (HYPER + VEH; n = 8), losartan (10 mg/kg/day; HYPER + LOS, n = 8), diltiazem (10 mg/kg/day; HYPER + DILT, n = 8), or propranolol (10 mg/kg/day; HYPER + PROP, n = 8). An echocardiographic study was performed at baseline, at the beginning and at the end of the pharmacological treatment protocol (35th day). The structural capillary density in the left ventricle (LV) was analyzed using histochemical analysis with fluorescein isothiocyanate-conjugated Griffonia simplicifolia lectin. HYPER + VEH (182 ± 5 mmHg; P < 0.001) presented higher systolic blood pressure (SBP) compared with EUT + VEH (132 ± 3 mmHg). HYPER + LOS (144 ± 2 mmHg), HYPER + DILT (147 ± 3 mmHg) and HYPER + PROP (153 ± 4 mmHg) presented lower SBP compared with HYPER + VEH (P < 0.001). Chronic treatment with losartan, diltiazem, and propranolol reversed cardiac structural microvascular rarefaction (HYPER + VEH 0.16 ± 0.01; EUT + VEH 0.35 ± 0.02; HYPER + LOS 0.46 ± 0.03; HYPER + DILT 0.49 ± 0.02; HYPER + PROP 0.58 ± 0.04 (Vv[cap]/Vv[fib]); P < 0.001) and enhanced the LV ejection fraction of hyperthyroid rats (HYPER + VEH 71 ± 3; EUT + VEH 85 ± 2; HYPER + LOS 90 ± 3; HYPER

  15. Case report: delirium due to a diltiazem-fentanyl CYP3A4 drug interaction.

    PubMed

    Levin, Tomer T; Bakr, Mohamed Hussien; Nikolova, Tanya

    2010-01-01

    Fentanyl and diltiazem are frequently used medications. Diltiazem inhibits cytochrome P450 3A4 isoenzymes. This can suppress fentanyl metabolism. We present a case of delirium after coadministration of fentanyl and diltiazem. Cautious use is warranted while concomitantly administering fentanyl and diltiazem as this can potentiate fentanyl toxicity. Other 3A4 inhibitors include ketoconazole, erythromycin, nefazodone, ritonavir, delavirdine, aprepitant and imatinib. Psychosomatic medicine psychiatrists, pain and palliative care physicians and cardiologists in particular should be aware of this interaction. Copyright © 2010 Elsevier Inc. All rights reserved.

  16. Combined effects of benidipine and diltiazem on cardiohemodynamics in anesthetized dogs.

    PubMed

    Yao, Kozo; Maeda, Hiroshi; Ina, Yasuhiro; Sato, Miwa; Fujita, Kazuhiro; Kuwabara, Takashi; Kobayashi, Hiroyuki; Shirakura, Shiro

    2006-04-01

    We examined the combined effects of the calcium channel blockers 1,4-dihydropyridine (benidipine) and benzothiazepine (diltiazem) on cardiohemodynamics in anesthetized dogs. Benidipine (3 microg/kg) lowered blood pressure (BP) slightly and continuously increased coronary flow (CF). Diltiazem (300, 1000 microg/kg) decreased BP, heart rate (HR), and the maximum rate of rise of left ventricular pressure (LV dP/dt max) with the increase of doses. Diltiazem increased CF, though it was transient when compared to benidipine. A combination of benidipine (3 microg/kg) and diltiazem (300 microg/kg) showed continuous decreases in BP, HR, and LV dP/dt max, and an increase in CF that was similar to that recorded for the benidipine group. The level of double product (DP: systolic BPxHR, an index of myocardium energy consumption) in the combination group was significantly lower than that of the benidipine group. The plasma concentrations of benidipine and diltiazem in the combination group were similar to those of the groups receiving either drug. These results demonstrate that the combination of benidipine and diltiazem increases CF more continuously than diltiazem alone, and decreases DP more potently than benidipine alone, indicating that the combination therapy possesses favorable properties as a treatment for angina pectoris. Therefore, the combination of benidipine and diltiazem is suggested as a useful treatment for improving the clinical benefits of monotherapy for angina, compared with the use of diltiazem alone at higher doses.

  17. Desarrollo de fotonovelas para concienciar sobre trastornos de la conducta alimentaria en latinos en los Estados Unidos

    PubMed Central

    Reyes-Rodríguez, Mae Lynn; García, Marissa; Silva, Yormeri; Sala, Margarita; Quaranta, Michela; Bulik, Cynthia M.

    2016-01-01

    Resumen El objetivo de este estudio fue desarrollar fotonovelas, un tipo de novela gráfica popular en la población latina, para crear conciencia y educar sobre los trastornos de la conducta alimentaria (TCA). Cuatro caricaturas ilustradas y guiones adaptados para adultos y adolescentes de ambos sexos fueron presentados en discusiones focales y en una entrevista de profundidad. Diecisiete latinos adultos (14 mujeres; 3 hombres) y 10 adolescentes (9 féminas; 1 varón) participaron en el estudio. Los participantes encontraron las fotonovelas interesantes y que captaban más la atención que los folletos tradicionales. El uso del espanglish y la clarificación de las diferencias entre los TCA fueron sugeridos por las adolescentes femeninas. Los adultos varones sugirieron cambiar el título, que se enfocara en las consecuencias en la salud de los TCA para que llame la atención en los hombres a leer la historia. Basado en la aceptación encontrada en este estudio, la fotonovela pudiera ser una avenida prometedora para crear conciencia y educar a la comunidad latina sobre los TCA en los Estados Unidos. PMID:27313838

  18. Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study.

    PubMed

    Jonas, Marion; Speake, William; Scholefield, John H

    2002-08-01

    Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal fissures. This study evaluated the efficacy of diltiazem for fissures that failed to heal with glyceryl trinitrate. Consecutive patients with persistent chronic fissures despite treatment with 0.2 percent glyceryl trinitrate ointment underwent anal manometry before and for 1 hour after application of 700 mg of 2 percent diltiazem gel to the distal anal canal. Patients applied diltiazem twice daily for eight weeks or until the fissure had healed. At fortnightly review, fissure healing was assessed, and side effects were noted. Patients scored symptoms of pain, bleeding, and irritation using linear visual analog scales at the initial and follow-up visits. In 39 patients (13 males; median age, 42 (range, 20- 80) years), topical 2 percent diltiazem gel lowered anal resting pressure by 20 percent from a median of 93 to 74 cm H2O (P < 0.0001, Wilcoxon), and fissures healed in 19 (49 percent) within 8 weeks. Before diltiazem, 27 patients (69 percent) had used a complete course of glyceryl trinitrate (0.5 g twice daily for 8 weeks), and 12 (44 percent) of these healed with diltiazem. The remaining 12 patients had discontinued glyceryl trinitrate prematurely or used less because of headaches; 7 (58 percent) of these healed with diltiazem, and 5 (42 percent) did not. Side effects occurred in four patients (10 percent): three reported perianal itching but continued with treatment, and one developed headaches, drowsiness, and mood swings six weeks into treatment and stopped diltiazem at that time. Topical 2 percent diltiazem is effective treatment for glyceryl trinitrate-resistant chronic anal fissures. Side effects, mainly perianal itching, may occur in 10 percent of patients but are generally tolerated.

  19. Myocardial cell membrane stress ionic dyskinesia reversal by diltiazem

    PubMed Central

    Gomes, OM; Gomes, ES

    2006-01-01

    Based on previous observations of cardioplegic ionic myocardial distress, myocardial stress dyskinesia was investigated as another possible cause of exercise stress testing-induced silent myocardial ischemia by analyzing the efficacy of the myocytic calcium channel blocker diltiazem in normalizing the results of patients who previously tested positive. From October 2004 to February 2006, 25 patients (13 women [52%]; aged between 28 and 71 years; mean age 56.9 years) complaining of precordial pain, with no coronary artery obstruction detected by scintigraphy and coronary cineangiography studies, presenting with positive ergometric testing, defined by ST segment depression, with no precordial pain or arrhythmia during testing, were treated with diltiazem in three daily doses of 90 mg, and were restudied five or seven days after the first examination. Treadmill electrocardiography exercise testing was performed using the standard Bruce protocol, analyzing the following parameters: the J point and Y point of the ST segment depression, maximum oxygen uptake reached, heart rate, double product and exercise performance measured in metabolic equivalents. The administration of diltiazem abolished patients’ complaints of atypical precordial pain in all cases and blocked ST segment depression, both J point (control: mean 2.3±0.5 mm; with treatment: 0.4±0.5 mm; P<0.001) and Y point (control: mean 1.9±0.7 mm; with treatment: 0.1±0.3 mm; P<0.001). The heart rate variations were not significant (P>0.05), with mean values of 156.2±12.0 beats/min for the control and 149.0±19.2 beats/min with treatment. There was significant (P<0.01) improvement in the functional classification of the heart with treatment (mean 2.7±0.9 for the control and 2.0±0.7 with treatment), without significant variations (P>0.05) in maximum oxygen uptake and double product results. The administration of the myocytic calcium channel blocker diltiazem impeded the occurrence of the silent ST segment

  20. Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride.

    PubMed

    Bathool, Afifa; Gowda, D V; Khan, Mohammed S; Ahmed, Ayaz; Vasudha, S L; Rohitash, K

    2012-04-01

    Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action. The tablets were prepared by wet granulation method. The prepared tablets were coated with microporous semipermeable membrane and enteric polymer using conventional pan coating process. The incorporation of sodium lauryl sulfate (SLS), a leachable pore-forming agent, could form in situ delivery pores while coming in contact with gastrointestinal medium. The effect of formulation variables was studied by changing the amounts of sodium alginate and NaCMC in the tablet core, osmogen, and that of pore-forming agent (SLS) used in the semipermeable coating. As the amount of hydrophilic polymers increased, drug release rate prolonged. It was found that drug release was increased as the concentration of osmogen and pore-former was increased. Fourier transform infrared spectroscopy and Differential scanning calorimetry results showed that there was no interaction between drug and polymers. Scanning electron microscopic studies showed the formation of pores after predetermined time of coming in contact with dissolution medium. The formation of pores was dependent on the amount of pore former used in the semipermeable membrane. in vitro results showed acid-resistant, timed release at an almost zero order up to 24 hours. The developed osmotic tablets could be effectively used for prolonged delivery of Diltiazem HCl.

  1. Diltiazem as augmentation therapy in patients with treatment-resistant bipolar disorder: a retrospective study.

    PubMed Central

    Silverstone, P H; Birkett, L

    2000-01-01

    OBJECTIVE: To examine the efficacy of a slow-release formulation of diltiazem as adjunctive therapy in patients with treatment-resistant bipolar disorder. DESIGN: Retrospective study. PATIENTS: Eight female patients with treatment-resistant bipolar disorder. INTERVENTIONS: Patients were administered diltiazem and monitored for a 6-month period before starting diltiazem and a 6-month period after starting the drug. OUTCOME MEASURES: All patients were seen at least monthly and usually every 2 weeks. The frequency and severity of both depressive and manic episodes were examined during the 6-month period after starting diltiazem, and compared with those during the 6-month period before diltiazem treatment. RESULTS: There was a statistically significant decrease in the frequency and severity of both manic and depressive episodes in these patients after they started treatment with diltiazem, compared with the period before they started treatment with diltiazem (p < 0.001). There was no evidence of side effects requiring patient withdrawal or of drug interactions. CONCLUSIONS: The results support previous suggestions that calcium-channel antagonists may be an effective adjunctive treatment in the management of bipolar disorder. Further controlled clinical studies are needed to confirm this small, open-label, retrospective study. PMID:10863888

  2. The solubility-modulated osmotic pump: in vitro/in vivo release of diltiazem hydrochloride.

    PubMed

    McClelland, G A; Sutton, S C; Engle, K; Zentner, G M

    1991-01-01

    A generalized method was investigated for conversion of controlled-porosity osmotic pump release profiles from first-order to zero-order kinetics using diltiazem.HCl as a model drug. Diltiazem.HCl has an aqueous solubility greater than 590 mg/ml (37 degrees C) and was released from controlled-porosity osmotic pump devices with first-order kinetics. This high solubility was markedly reduced (155 mg/ml; 37 degrees C) in the presence of NaCl (1 M). Based on theory for osmotically actuated drug release, this reduced solubility would be expected to result in a zero-order release profile of greater than 80% of an initial diltiazem.HCl load. Devices were prepared with cores that contained diltiazem.HCl and sufficient NaCl granules coated with a microporous cellulose acetate butyrate 381-20 film to maintain a 1 M NaCl concentration within the drug compartment over a 16-hr period. This resulted in release of approximately 75% of the initial diltiazem.HCl load with zero-order kinetics over a 14- to 16-hr period. The in vivo performance of these devices in beagle dogs was analyzed. The in vivo percentage diltiazem absorbed profiles were superimposable with the in vitro release profile. These results suggest that diltiazem release and absorption from the solubility modulated osmotic pump occur throughout the GI tract in a fashion predictable from in vitro dissolution data.

  3. [A comparative study of intravenous diltiazem and nitroglycerin in the treatment of unstable angina].

    PubMed

    Fiol, M; Costa, A; Suárez-Pinilla, M A; de Armas, D; Bergadá, J; Bosch, E

    1992-02-01

    To compare the efficacy of intravenous diltiazem vs nitroglycerin in patients with unstable angina, we conducted a prospective, single blinded study enrolling 45 patients, 24 of them received diltiazem and 21 nitroglycerin. We considered drug failure if the patient experienced two or more anginal episodes or if one of them was longer than 30 minutes. There was a good response in 19 of 24 patients (79%) of the diltiazem group and 17 of 21 (81%) in the nitroglycerin group. Only one of the 5 non-response patients in the diltiazem group that was crossed to nitroglycerin was controlled, in opposition to the 4 patients crossed to diltiazem that were controlled all of them (p less than 0.05). Both drugs significantly (p less than 0.01) reduced systolic and diastolic blood pressure, but there was not difference between the two groups. Heart rate and double product decreased only in the diltiazem group (p less than 0.05). We did not find notorious side effects. We concluded that diltiazem is an alternative to nitroglycerin in patients with unstable angina.

  4. Mechanisms of action of diltiazem in isolated human atrial and ventricular myocardium.

    PubMed

    Sutton, M S; Morad, M

    1987-05-01

    A comparative study of human atrial fibers (HAF), human ventricular fibers (HVF), frog ventricle, and frog skeletal muscle demonstrated marked differences in tension development in the presence of diltiazem. There was no significant difference between the tension developed by HAF and by HVF over a range of diltiazem concentrations when the differences in resting membrane potential were corrected by increasing external K+ concentration. In human myocardium, diltiazem resulted in both a voltage and use-dependent blockade of the calcium channel. Comparison of the tension-dose response curves in human myocardium, frog ventricle and skeletal muscle showed that diltiazem was most effective at decreasing tension in frog heart, and least effective in skeletal muscle with human myocardium being intermediate. In skeletal muscle, neither tension development nor the birefringence signal related to the Ca2+ release from the sarcoplasmic reticulum was significantly altered by Diltiazem in concentrations less than 10(-6) M, but in concentrations greater than 10(-5) M both were suppressed. Diltiazem suppressed tension in human myocardium over the range of membrane potentials associated with Ca2+ channel activity, while at more positive potentials, diltiazem appeared to have little effect on the tension-voltage relations. Diltiazem had no effect upon tension development induced by acetyl strophanthidin in human myocardium or upon the Ca2+ sensitivity of chemically skinned atrial or ventricular fibers. Thus the tension-suppressant effect of diltiazem in human myocardium appears to be mediated by a combination of voltage-dependent block of the Ca2+ channel and inhibition of Ca2+ release from internal stores, and not from alterations in either Na+-Ca2+ coupled transport or Ca2+ sensitivity of the myofilaments.

  5. La utilizacion de los mapas conceptuales en la ensenanza de biologia y su efecto sobre el dominio del proceso de fotosintesis en los estudiantes universitarios

    NASA Astrophysics Data System (ADS)

    Gonzalez Rivera, Maria M.

    Se investigo el efecto de los mapas conceptuales sobre el dominio del proceso de fotosintesis en estudiantes universitarios. La investigacion utilizo dos estrategias: mapas conceptuales individuales y mapas conceptuales colaborativos, con el fin de investigar si existen diferencias significativas en el dominio del proceso de fotosintesis. El analisis de los datos incluyo aspectos cualitativos y cuantitativos. Se desprende del estudio que el 80% de los estudiantes describen la utilizacion de los mapas conceptuales como una experiencia beneficiosa. El 70% de los estudiantes expreso que los mapas conceptuales son utiles en el aprendizaje del proceso de fotosintesis y el 61% indico que facilitan la comprension de los conceptos. Los hallazgos mas importantes del analisis cuantitativo indican que los estudiantes que utilizaron los mapas conceptuales mejoraron significativamente su desempeno en la posprueba global. Se utilizo la prueba Mann-Whitney para investigar si existian diferencias significativas en la posprueba y preprueba global, el valor de W = 1945.0, para un valor p de 0.00, lo cual establece diferencias significativas. Para determinar si existian diferencias significativas entre la posprueba y preprueba del grupo individual, se realizo la prueba nuevamente. El valor de W correspondio a 490.5, que es significativo, con un valor p de 0.00. Se concluye que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo individual. Los datos proveen suficiente evidencia para sostener que los estudiantes que utilizaron la estrategia de mapas conceptuales individuales mejoraron el dominio del proceso de fotosintesis significativamente. Se realizo nuevamente la prueba para los resultados de posprueba y preprueba del grupo colaborativo. El valor de W correspondio a 446 con un valor p de 0.00. Se concluyo que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo colaborativo. Finalmente, se efectuo una

  6. [Treatment of chronic anal fissures: diltiazem or isosorbide dinitrate as first choice?].

    PubMed

    Boeker, Eveline B; Kruijer, M J P Marjan; Verbeek, Paul C M

    2011-01-01

    Chronic anal fissures are a painful condition frequently seen in general practice, with an incidence of 2,5/1000 per year. According to the practice guidelines of the Dutch College of General Practitioners, isosorbide dinitrate 1% ointment (ISDN) is the treatment of first choice for chronic anal fissures. Systemic side-effects such as headache are reported in 27% of all cases. This side effect in combination with the frequent application of ISDN (4-6 times daily) leads to a low compliance for this therapy. A meta-analysis of the Cochrane Collaboration showed similar efficacy of diltiazem compared to ISDN. Diltiazem has several advantages: the application frequency is only twice daily, no systemic side-effects have been reported, the total costs of treatment are lower than the costs of ISDN and a standard preparation of diltiazem ointment is available. Therefore, diltiazem 2% ointment should be the first line treatment for chronic anal fissures.

  7. Combined effects of benidipine and diltiazem in a rat model of experimental angina.

    PubMed

    Yao, Kozo; Shirakura, Shiro

    2004-07-01

    We examined the combined effects of the calcium channel blockers 1,4-dihydropyridine (benidipine) and benzothiazepine (diltiazem) on vasopressin-induced myocardial ischemia in anesthetized rats, an experimental model of angina. Benidipine (3, 10 microg/kg, i.v.) and diltiazem (300, 1000 microg/kg, i.v.) caused dose-related inhibition of vasopressin-induced S-wave depression, an index of myocardial ischemia. Co-administration of low doses of benidipine (3 microg/kg) and diltiazem (300 microg/kg) almost completely inhibited the S-wave depression, where the efficacy was similar to that obtained with the use of high doses of benidipine (10 microg/kg) or diltiazem (1000 microg/kg). These results suggest that the administration strategy employed may be useful in the treatment of angina pectoris.

  8. Sustained transdermal release of diltiazem hydrochloride through electron beam irradiated different PVA hydrogel membranes

    NASA Astrophysics Data System (ADS)

    Bhunia, Tridib; Goswami, Luna; Chattopadhyay, Dipankar; Bandyopadhyay, Abhijit

    2011-08-01

    Extremely fast release of diltiazem hydrochloride (water soluble, anti anginal drug used to treat chest pain) together with its faster erosion has been the primary problem in conventional oral therapy. It has been addressed in this paper by encapsulating the drug in electron beam irradiated various poly (vinyl alcohol) hydrogel membranes and delivering it through transdermal route. Results show excellent control over the release of diltiazem hydrochloride through these membranes subject to their physico-mechanicals.

  9. Diltiazem Treatment for Preclinical Hypertrophic Cardiomyopathy Mutation Carriers: A Pilot Randomized Trial to Modify Disease Expression

    PubMed Central

    Ho, Carolyn Y.; Lakdawala, Neal K.; Cirino, Allison L.; Lipshultz, Steven E.; Sparks, Elizabeth; Abbasi, Siddique A.; Kwong, Raymond Y.; Antman, Elliott M.; Semsarian, Christopher; González, Arantxa; López, Begoña; Diez, Javier; Orav, E. John; Colan, Steven D.; Seidman, Christine E.

    2014-01-01

    Background Hypertrophic cardiomyopathy (HCM) is caused by sarcomere mutations and characterized by left ventricular hypertrophy (LVH) with increased risk of heart failure and sudden death. HCM typically cannot be diagnosed early in life, although subtle phenotypes are present. Animal studies indicate alterations in intracellular calcium handling before LVH develops. Furthermore, early treatment with diltiazem appeared to attenuate disease emergence. Objectives To assess the safety, feasibility, and effect of diltiazem as disease-modifying therapy for at-risk HCM mutation carriers. Methods In a pilot, double-blind trial, we randomly assigned 38 sarcomere mutation carriers without LVH (mean age 15.8 years) to therapy with diltiazem 360 mg/day (or 5 mg/kg/day) or placebo. Treatment duration ranged from 12 to 42 months (median 25 months). Study procedures included electrocardiography, echocardiography, cardiac magnetic resonance imaging, and serum biomarker measurement. Results Diltiazem was not associated with serious adverse events. Heart rate and blood pressure did not differ significantly between groups. However, mean left ventricular end diastolic diameter improved towards normal in the diltiazem group but decreased further in controls (change in z-scores, +0.6 vs. −0.5; P<0.001). Mean LV thickness-to-dimension ratio was stable in the diltiazem group, but increased in controls (−0.02 vs. +0.15; P=0.04). Among MYBPC3 mutation carriers, LV wall thickness and mass, diastolic filling, and cardiac troponin I levels improved in those taking diltiazem compared with controls. Four participants developed overt HCM, two in each treatment group. Conclusions Preclinical administration of diltiazem is safe and may improve early LV remodeling in HCM. This novel strategy merits further exploration. PMID:25543971

  10. A randomized trial of oral vs. topical diltiazem for chronic anal fissures.

    PubMed

    Jonas, M; Neal, K R; Abercrombie, J F; Scholefield, J H

    2001-08-01

    Chemical sphincterotomy has proved effective in treating chronic anal fissure. Glyceryl trinitrate is the most widely used agent, and topical 0.2 percent glyceryl trinitrate ointment heals up to two thirds of chronic anal fissures. Unfortunately, however, many patients experience troublesome headaches as a side effect of this treatment. This study assessed the effectiveness of oral and topical diltiazem in healing chronic fissures. Fifty consecutive patients with chronic anal fissures were randomly assigned to receive oral (60 mg) or topical (2 percent gel) diltiazem twice daily for up to eight weeks. Anal manometry was performed before and after the first dose, and blood pressure was recorded at 15-minute intervals. Patients were reviewed fortnightly, pain was expressed with a visual linear analog scale, blood pressure was recorded, fissure healing was assessed, and side effects were noted. Twenty-four patients received oral diltiazem, and 26 received topical diltiazem. Mean (+/- standard error of the mean) maximum resting anal pressures fell by 15 and 23 percent from 95 +/- 4 to 81 +/- 4 and from 102 +/- 5 to 79 +/- 5 cm H2O in the two groups, respectively. There was no significant reduction in blood pressure during the study or at follow-up in either group. Fissure healing was complete in 9 patients (38 percent) receiving oral diltiazem and 15 (65 percent) on topical treatment by eight weeks. Oral diltiazem caused side effects in eight patients (rash, two; headaches, two; nausea or vomiting, three; reduced smell and taste, one), whereas no side effects were seen in those receiving topical therapy (P = 0.001). Oral and topical diltiazem heal chronic anal fissures. Topical diltiazem is more effective, achieving healing rates comparable to those reported with topical nitrates, with significantly fewer side effects.

  11. Cisplatin-Induced Ototoxicity and the Effects of Intratympanic Diltiazem in a Mouse Model.

    PubMed

    Naples, James G; Parham, Kourosh

    2016-01-01

    To evaluate whether the calcium-channel blocker diltiazem has protective effects against cisplatin-induced ototoxicity in a mouse model. Original basic science in vivo investigation. Academic setting: Otolaryngology-Head and Neck Surgery laboratory at University of Connecticut Health Center. Thirty-nine female CBA/J mice. Pure tone- or click-evoked auditory brainstem responses (ABRs) were recorded in CBA/J mice to determine auditory thresholds. All mice had baseline ABRs recorded. They were then given a single cisplatin bolus (14 mg/kg), followed by 5 consecutive days of intratympanic diltiazem or saline control. Follow-up thresholds were recorded on days 7, 14, and 21 postcisplatin. Tone-evoked ABRs evaluated the otoprotective effect of 2-mg/kg diltiazem in 9 mice, and dose effect was examined in response to click-evoked ABR with 2- or 4-mg/kg diltiazem in 2 groups of 15 mice. Saline-treated ears had significantly elevated tone-evoked auditory thresholds when compared with diltiazem-treated ears (P = .038) on day 7 postcisplatin only. Click-evoked ABR thresholds were significantly elevated in saline-treated ears versus diltiazem-treated ears for the 2-mg/kg group (P = .001) and 4-mg/kg group (P = .011) on days 7, 14, and 21 postcisplatin. Intratympanic diltiazem has significant protective effects against cisplatin ototoxicity at 2 and 4 mg/kg. This is the first in vivo study to demonstrate that diltiazem offers a potentially novel therapy for cisplatin-induced ototoxicity. © American Academy of Otolaryngology-Head and Neck Surgery Foundation 2015.

  12. Rapid reversal of life-threatening diltiazem-induced tetany with calcium chloride.

    PubMed

    Vinson, D R; Burke, T F; Sung, H M

    1999-11-01

    We describe a patient who developed tetany with sudden respiratory arrest after the infusion of intravenous diltiazem. The administration of calcium chloride rapidly resolved the patient's tetany with prompt recovery of respiratory function, averting the need for more aggressive airway management and ventilatory support. The emergency physician should be aware that life-threatening tetany may accompany the administration of intravenous diltiazem and that calcium chloride may be a rapid and effective remedy.

  13. The Effect of Diltiazem and Nifedipine on the Rate of Metabolism of Midazolam

    DTIC Science & Technology

    2000-10-01

    the benzothiapine group and nifedipine is the prototype drug in the dihydropyridine group. Diltiazem interacts with the calcium 2 channel receptor in...a different fashion then nifedipine of the dihydropyridine group. Diltiazem is more selective in blocking the calcium-dependent cells in the...atrioventricular node and is therefore more beneficial for tachycardias and arrhythmias. On the other hand, the dihydropyridine prototypical drug nifedipine

  14. The Effect of Diltiazem and Nifedipine on the Rate of Metabolism of Midazolam

    DTIC Science & Technology

    2000-10-01

    belongs to the benzothiapine group and nifedipine is the prototype drug in the dihydropyridine group. Diltiazem interacts with the calcium 2 channel...receptor in a different fashion then nifedipine of the dihydropyridine group. Diltiazem is more selective in blocking the calcium-dependent cells in the...atrioventricular node and is therefore more beneficial for tachycardias and arrhythmias. On the other hand, the dihydropyridine prototypical drug

  15. Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem.

    PubMed

    Gandía, L; Villarroya, M; Sala, F; Reig, J A; Viniegra, S; Quintanar, J L; García, A G; Gutiérrez, L M

    1996-07-01

    1. The effects of diltiazem on various functional parameters were studied in bovine cultured adrenal chromaffin cells stimulated with the nicotinic receptor agonist dimethylphenylpiperazinium (DMPP) or with depolarizing Krebs-HEPES solutions containing high K+ concentrations. 2. The release of [3H]-noradrenaline induced by DMPP (100 microM for 5 min) was gradually and fully inhibited by increasing concentrations of diltiazem (IC50 = 1.3 microM). In contrast, the highest concentration of diltiazem used (10 microM) inhibited the response to high K+ (59 mM for 5 min) by only 25%. 3. 45Ca2+ uptake into cells stimulated with DMPP (100 microM for 1 min) was also blocked by diltiazem in a concentration-dependent manner (IC50 = 0.4 microM). Again, diltiazem blocked the K(+)-evoked 45Ca2+ uptake (70 mM K+ for 1 min) only by 20%. In contrast, the N-P-Q-type Ca2+ channel blocker omega-conotoxin MVIIC depressed the K+ signal by 70%. In the presence of this toxin, diltiazem exhibited an additional small inhibitory effect, indicating that the compound was acting on L-type Ca2+ channels. 4. Whole-cell Ba2+ currents through Ca2+ channels in voltage-clamped chromaffin cells were inhibited by 3-10 microM diltiazem by 20-25%. The inhibition was readily reversed upon washout of the drug. 5. The whole-cell currents elicited by 100 microM DMPP (IDMPP) were inhibited in a concentration-dependent and reversible manner by diltiazem. Maximal effects were found at 10 microM, which reduced the peak IDMPP by 70%. The area of each curve represented by total current (QDMPP) was reduced more than the peak current. At 10 microM, the inhibition amounted to 80%; the IC50 for QDMPP inhibition was 0.73 microM, a figure close to the IC50 for 45Ca2+ uptake (0.4 microM) and [3H]-noradrenaline release (1.3 microM). The blocking effects of diltiazem developed very quickly and did not exhibit use-dependence; thus the drug blocked the channel in its closed state. The blocking effects of 1 microM diltiazem on

  16. Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers

    PubMed Central

    Teng, Renli; Butler, Kathleen

    2013-01-01

    Objectives Two open-label, two-period, crossover studies in healthy volunteers were designed to determine the pharmacokinetic interactions between ticagrelor, a P2Y12 receptor antagonist, and a moderate (diltiazem) and a strong (ketoconazole) cytochrome P450 (CYP) 3A inhibitor. Methods Seventeen volunteers received diltiazem (240 mg once daily) for 14 days. In the second study, ketoconazole (n = 14) 200 mg twice daily was given for 10 days. A single oral 90-mg ticagrelor dose was administered on day 8 (diltiazem) or day 4 (ketoconazole). In each study, volunteers received a single 90-mg oral dose of ticagrelor before or after washout (≥14 days). Pharmacokinetic parameters for ticagrelor, AR-C124910XX (primary metabolite), diltiazem, and ketoconazole were assessed. Results Compared with ticagrelor alone, diltiazem co-administration significantly increased the mean maximum concentration (Cmax) and mean area under the plasma concentration–time curve (AUC) for ticagrelor by 69% and 174%, respectively. Diltiazem co-administration reduced Cmax by 38% but had no significant effect on AUC for AR-C124910XX. Cmax and AUC for ticagrelor were increased by 135% and 632%, respectively, by ketoconazole co-administration, whereas these parameters were reduced by 89% and 56%, respectively, for AR-C124910XX. Diltiazem and ketoconazole pharmacokinetic parameters were not significantly affected by the presence of ticagrelor. Conclusions These results suggest that ticagrelor can be co-administered with moderate CYP3A inhibitors. However, co-administration of strong CYP3A inhibitors with ticagrelor is not recommended. PMID:27536435

  17. The Pharmacokinetics of Once-Daily Diltiazem SR (Sustained-Release) in Young Versus Elderly Hypertensive Patients.

    PubMed

    Argenti, Domenick; Huang, Mei-Ying; Heald, Donald; Ziemniak, John

    1994-08-01

    The objective of this open-label, outpatient, parallel-group investigation was to compare the single-dose and steady-state pharmacokinetic profiles of young (n = 12; x = 41 ± 6 years) and elderly (n = 12; X = 69 ± 4 years) hypertensive patients following administration of a once-daily formulation of diltiazem. The study was comprised of two phases. The first phase was a lead-in phase used to establish hypertensive status. In the second phase, patients were administered a single- and multiple-daily dose regimen of 240 mg of diltiazem SR. Plasma samples were obtained at selected times and analyzed for diltiazem using a specific and sensitive HPLC assay. Biopharmaceutic parameter estimates were determined and analyzed for statistical differences. Qualitatively similar concentration-time profiles were observed between groups, suggesting similar release characteristics of the sustained-release formulation. However, significantly higher overall concentrations of diltiazem were observed following single-dose administration in the elderly, possibly as a result of an age-related decrease in the apparent oral clearance of diltiazem. A further reduction in the apparent oral clearance of diltiazem with multiple-dose administration was observed in the elderly resulting in even higher than projected concentrations of diltiazem. Thus, greater oral systemic availability of diltiazem in the elderly hypertensive patients may warrant closer clinical monitoring and possibly a reduction in dosage.

  18. Amiloride and diltiazem inhibition of microsomal and mitochondrial Na+ and Ca2+ transport.

    PubMed

    Sordahl, L A; LaBelle, E F; Rex, K A

    1984-01-01

    Amiloride, a K+-sparing diuretic, and diltiazem, a Ca2+ channel antagonist, have both been reported to inhibit Na+ transport-associated processes in different subcellular membrane systems. In this report, similar inhibitory effects of both agents are demonstrated on Na+-induced Ca2+ release from rabbit heart mitochondria and on Na+ uptake in a kidney medulla microsomal preparation. Both amiloride and diltiazem produce 50% inhibition of Na+ uptake in kidney microsomes at the same concentrations. Heart mitochondrial Na+-induced Ca2+ release was 50% inhibited by 6 microM diltiazem and 200 microM amiloride. No effects of either agent on mitochondrial respiratory activity were observed. The results suggest a specific effect of both drugs on a Na+-binding site associated with an antiport exchange process. These data also extend previous observations suggesting the use of these agents as tools to define further ion transport mechanisms in biological membranes.

  19. Intrarectal Lidocaine-Diltiazem-Meperidine Gel for Transrectal Ultrasound Guided Prostate Biopsy

    PubMed Central

    Imani, Farsad; Moghaddam, Yasaman; Shariat Moharari, Reza; Etezadi, Farhad; Khajavi, Mohammad Reza; Hosseini, Seyed Reza

    2015-01-01

    Background: TRUS-guided needle biopsy of the prostate gland is the current standard method used for diagnosis of prostate cancer. Pain control during this procedure is through the use of i.v. sedation or local anaesthetic (LA), depending on clinician preference. Objectives: The aim of this study was to evaluate the effectiveness of intrarectal lidocaine, lidocaine-diltiazem and lidocaine-meperidine-diltiazem gel for anesthetizing transrectal ultrasound guided prostate biopsy. Patients and Methods: In a randomized double-blind clinical trial, 100 consecutive patients were divided into three groups. The patients received one of the gels before transrectal ultrasound guided prostate needle biopsy: group A, intrarectal and perianal lidocaine, gel 1 g; group B, intrarectal lidocaine gel, 1 g, + perianal diltiazem, 1 g; group C, intrarectal lidocaine gel, 1 g, + meperidine, 25 mg, and perianal diltiazem, 1 g. Visual analog pain scale was used to estimate pain during probe insertion and biopsy. Heart rate and blood pressure during probe insertion and biopsy were recorded too. Results: The mean of visual analog pain scale was 4.5 in group A, 3.5 in group B, and 2.0 in group C during probe insertion (P value = 0.01). The mean of visual analog pain scale was 5.1 in group A, 3.5 group B, and 2.5 in group C during biopsy (P value = 0.001). The groups were comparable for patients' age, weight, serum prostate-specific antigen (PSA), and prostate size (P > 0.05). No side effects of meperidine and lidocaine including drowsiness, dizziness, tinnitus and light-headedness or requiring assistance for activity were noted. Conclusions: Lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. This mixture gel is safe, easy to administer and well accepted by patients. PMID:26161317

  20. Diltiazem-associated photodistributed hyperpigmentation: report of two Japanese cases and published work review.

    PubMed

    Kubo, Yoshiaki; Fukumoto, Daisuke; Ishigami, Takeshi; Hida, Yasutoshi; Arase, Seiji

    2010-09-01

    Scherschum et al. proposed diltiazem-associated photodistributed hyperpigmentation as a novel type of drug-induced photosensitive lichenoid eruption. The characteristic clinical features were slate-gray reticulated hyperpigmentation on sun-exposed areas, while lichenoid dermatitis with prominent pigmentary incontinence was noted histologically. Although the clinical and histological features were similar to those of lichen planus pigmentosus, the histological features did not show either compact hyperkeratosis or wedge-shaped hypergranulosis, which are typical histological features of lichen planus. We describe two Japanese cases of diltiazem-associated photodistributed hyperpigmentation, who were successfully treated with topical tacrolimus, and review the published work.

  1. Microencapsulation by spray coagulation of diltiazem HCl in calcium alginate-coated chitosan.

    PubMed

    Tapia, Cristián; Montezuma, Víctor; Yazdani-Pedram, Mehrdad

    2008-01-01

    The aim of this work was to develop a procedure for encapsulation of diltiazem HCl by spray coagulation. Factors affecting the formulations such as the effect of NaCl on the solubility of diltiazem in alginate solution, surface tension, pH, viscosity of the coagulation medium, and the effect of drug load on drug release were studied. The drug load was increased substantially from 10 up to 320 mg/mL by adding 1.2% w/v NaCl in 1% w/v alginate solution. More stable microcapsules were obtained at pH 4.6 (acetate buffer) than at a pH 2.8 (lactic acid), and the microencapsulation process was favored by the type of chitosan that produced low turbidity and viscosity in the coagulation medium. A dose of 50 mg/mL of diltiazem HCl, 1.2% w/v NaCl, and chitosan CS allowed higher amount of drug to be encapsulated. The high water solubility of diltiazem HCl leads to fast release from the microcapsules.

  2. Metoprolol and diltiazem ameliorate ziprasidone-induced prolonged corrected QT interval in rats.

    PubMed

    Erbas, Oytun; Yilmaz, Mustafa

    2015-12-01

    Ziprasidone, an atypical antipsychotic agent, has been shown to increase the corrected QT (QTc) interval in some patients. The aim of this study was to reveal the effects of metoprolol and diltiazem on ziprasidone drug-induced prolonged QTc interval. A total of 24 rats were equally divided into the following four groups: the first group was used as the control and received 1 mL/kg saline; 3 mg/kg ziprasidone and saline were administered to the second group; 3 mg/kg ziprasidone and 1 mg/kg metoprolol were administered to the third group and 3 mg/kg ziprasidone and 2 mg/kg diltiazem were administered to the fourth group. Two hours following application of the drugs, the QTc was calculated by performing electrocardiography in derivation (D)I. The duration of QTc interval was compared among the four groups. The mean QTc intervals were significantly increased in the third and fourth groups compared with the second group (p < 0.0005 and p < 0.0001, respectively). The study demonstrated the effectiveness of metoprolol and diltiazem in the prevention of ziprasidone-induced elongation in the QTc interval. Both metoprolol and diltiazem may be considered in the prophylactic therapy of high-risk patients who are using ziprasidone.

  3. Prognostic effects of benidipine in patients with vasospastic angina: comparison with diltiazem and amlodipine.

    PubMed

    Fukumoto, Yoshihiro; Yasuda, Satoshi; Ito, Akira; Shimokawa, Hiroaki

    2008-03-01

    We have previously reported the changing clinical characteristics of patients with vasospastic angina (VSA) before and after the introduction of new calcium channel blockers (benidipine and amlodipine) in 1990. In this subanalysis study, we compared the prognostic effects of 3 calcium channel blockers (benidipine, diltiazem, and amlodipine) on the incidence of cardiovascular events in patients with VSA in our cohort study, where 527 patients (318 men and 209 women) enrolled after 1990 (from January 1990 to December 2002) were followed-up for a mean period of 5.2 years. There was no significant difference in the clinical characteristics among the 3 calcium channel blocker groups. Multivariate analysis demonstrated that 4 factors, including smoking, hypertension, diabetes mellitus and reduced left ventricular ejection fraction, were significant risk factors for cardiovascular events. Among the 3 calcium channel blockers examined, benidipine (n = 148) tended to be associated with a lower incidence of total events, cardiovascular events, and cerebral infarction, compared with diltiazem (n = 313) and amlodipine (n = 111). Furthermore, benidipine significantly reduced the incidence of vascular infarction events, a possible indicator of atherosclerosis, as compared with diltiazem. These results suggest that benidipine may be more useful for the treatment of VSA as compared with diltiazem and amlodipine.

  4. Effect of long-term diltiazem treatment on central haemodynamics and exercise endurance in essential hypertension.

    PubMed

    Lund-Johansen, P; Omvik, P

    1990-06-01

    The effects of long-term treatment with diltiazem on blood pressure, central haemodynamics and exercise endurance were studied in 16 men (mean age 52 years) with essential hypertension. Intra-arterial pressure and heart rate (HR) were monitored continuously. Cardiac output (CO) was measured by Cardiogreen at rest (supine and sitting) and during 50 W, 100 W and 150 W bicycle exercise. Haemodynamic measurements were repeated after continuous bicycling at 150 W for 20 min or until exhaustion. After 1 year on diltiazem (mean daily dose 278 mg) intra-arterial pressure was reduced (P less than 0.001) in all situations (at rest sitting from 183/108 mmHg to 157/92 mmHg (14%] due to reduction in total peripheral resistance. HR was reduced at rest (7%) and during exercise (10%). Stroke volume tended to increase while CO was unchanged. Exercise time at constant workload increased by 25%. After a peak level, intra-arterial pressure fell by 3% to 5% (P less than 0.05) due to a decrease in total peripheral resistance both before and during diltiazem treatment. Stroke volume and CO remained unchanged during endurance exercise while HR showed a small increase. Thus, there was no reduction in the overall cardiac pump function after long-term diltiazem treatment, and blood flow during exercise was maintained.

  5. Release profile comparison and stability of diltiazem-resin microcapsules in sustained release suspensions.

    PubMed

    Junyaprasert, Varaporn Buraphacheep; Manwiwattanakul, Greepol

    2008-03-20

    A sustained release suspension of diltiazem, a short half-life calcium channel blocker, was developed to reduce frequency of drug administration, ease of dose adjustment and improve patient compliance. In this study, the sustained release of diltiazem was obtained by complexing the drug with Dowex 50W x 4 and Dowex 50W x 8, strong cationic exchange resins with 4% and 8% degree of cross-linking, respectively. The diltiazem-Dowex 50W x 4 complexes provided the highest drug release and were subsequently used to prepare the microcapsules by emulsion-solvent evaporation method, using 0.75-5.00% cellulose acetate butyrate (CAB) in methylene chloride as a coating solution. As the concentration of CAB increased, the size of microcapsule increased and the drug release from the microcapsule was retarded. From release profile comparison using f(1) and f(2) factors, it was found that the microcapsules coated with 1.75% CAB provided a release profile equivalent to the commercial product of diltiazem sustained release capsule, Herbesser 90SR. Furthermore, sustained release suspensions of the diltiazem microcapsules were formulated with the use of 0.8% sodium carboxymethylcellulose or 0.4% xanthan gum as a suspending agent. The suspension of 0.4% xanthan gum showed superior in physical appearance after 120-day storage at 30 and 45 degrees C. In addition, all sustained release suspensions possessed good stability with low drug leaching and their release profiles were unchanged when compared with the dried microcapsules for 120 days at 30 and 45 degrees C.

  6. Diltiazem vs. Metoprolol in the Management of Atrial Fibrillation or Flutter with Rapid Ventricular Rate in the Emergency Department.

    PubMed

    Fromm, Christian; Suau, Salvador J; Cohen, Victor; Likourezos, Antonios; Jellinek-Cohen, Samantha; Rose, Jonathan; Marshall, John

    2015-08-01

    Diltiazem (calcium channel blocker) and metoprolol (beta-blocker) are both commonly used to treat atrial fibrillation/flutter (AFF) in the emergency department (ED). However, there is considerable regional variability in emergency physician practice patterns and debate among physicians as to which agent is more effective. To date, only one small prospective, randomized trial has compared the effectiveness of diltiazem and metoprolol for rate control of AFF in the ED and concluded no difference in effectiveness between the two agents. Our aim was to compare the effectiveness of diltiazem with metoprolol for rate control of AFF in the ED. A convenience sample of adult patients presenting with rapid atrial fibrillation or flutter was randomly assigned to receive either diltiazem or metoprolol. The study team monitored each subject's systolic and diastolic blood pressures and heart rates for 30 min. In the first 5 min, 50.0% of the diltiazem group and 10.7% of the metoprolol group reached the target heart rate (HR) of <100 beats per minute (bpm) (p < 0.005). By 30 min, 95.8% of the diltiazem group and 46.4% of the metoprolol group reached the target HR < 100 bpm (p < 0.0001). Mean decrease in HR for the diltiazem group was more rapid and substantial than that of the metoprolol group. From a safety perspective, there was no difference between the groups with respect to hypotension (systolic blood pressure < 90 mm Hg) and bradycardia (HR < 60 bpm). Diltiazem was more effective in achieving rate control in ED patients with AFF and did so with no increased incidence of adverse effects. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.

    PubMed

    Zucker, M L; Budd, S E; Dollar, L E; Chernoff, S B; Altman, R

    1993-08-02

    The authors studied the effects of diltiazem, administered alone and together with low-dose aspirin, on the platelet response to paired agonists. After a baseline period, 25 healthy volunteers were given oral diltiazem for 1 week (120, 240, or 360 mg/day), and then crossed over randomly between 1 week on diltiazem plus aspirin (81 mg/day), and 1 week on aspirin (81 mg/day) alone. Platelet function was tested on 2 consecutive days in each period. Synergistic platelet aggregation and ATP release were obtained at baseline using a subthreshold concentration of arachidonic acid combined with platelet activating factor, ADP, or epinephrine. Diltiazem resulted in significant decrease from baseline in platelet aggregation and ATP release using the arachidonic acid-epinephrine combination (35% and 40% decrease, respectively, p < 0.01) and a significant decrease in aggregation using the arachidonic acid-ADP combination (22% decrease, p < 0.01). The effects were neither dose-related, nor accompanied by any significant change in serum thromboxane B2 levels or bleeding times. There was no significant difference between the effects of aspirin alone and aspirin plus diltiazem on the synergistic platelet aggregation and ATP release induced by the paired agonists, or on thromboxane B2 levels or bleeding times. Diltiazem administered in vivo partially inhibits the synergistic platelet aggregation and ATP release induced by paired agonists; however, in contrast to a previous in vitro study it does not potentiate the platelet-inhibitory effect of aspirin.

  8. Differential bronchodilatory effects of terbutaline, diltiazem, and aminophylline in canine intraparenchymal airways.

    PubMed

    Akhtar, S; Mazzeo, A J; Cheng, E Y; Bosnjak, Z; Kampine, J P

    1999-08-01

    Intraparenchymal airways are involved in air flow regulation. Relaxation of intraparenchymal airways to volatile anesthetics varied by topographic location. This study was conducted to determine whether other bronchodilators (terbutaline, diltiazem, and aminophylline) relax bronchiolus to a greater degree than bronchus, as seen with volatile anesthetics. In vitro, controlled, randomized study. Animal research laboratory. Adult dogs (n = 9). Proximal (outer diameter, 4-6 mm) and distal (outer diameter, 0.8-1.5 mm) airway rings of dogs were contracted in tissue baths with the effective concentration of acetylcholine that produces half the maximum response. Airway relaxant dose-response curves were constructed to measure isometric tension after administration of terbutaline (concentration range, 10(-8) to 10(-4) M), diltiazem (concentration range, 3 x 10(-7) to 1 x 10(-4) M), and aminophylline (concentration range, 10(-7) to 10(-4) M). All three bronchodilators caused relaxation of the proximal and distal airways. At the maximum dose, diltiazem (maximum relaxation, 95%+/-2% [proximal], 94%+/-6% [distal]; p > .05) was the most efficacious, followed by terbutaline (maximum relaxation, 72%+/-13% [proximal], 55%+/-9% [distal]; p < .05) and aminophylline (maximum relaxation, 32%+/-10% [proximal], 35%+/-18% [distal]; p > .05. At the concentrations tested, they were equally efficacious. No significant differences in relaxation between proximal and distal airways were noted with diltiazem or aminophylline in the entire dose range. However, terbutaline relaxed the distal airway more than the proximal airway in the entire dose range. The results demonstrate that only terbutaline showed a differential airway relaxant effect between proximal and distal airways, as seen with volatile anesthetics.

  9. Protective effect of a calcium channel blocker "diltiazem" on aluminum chloride-induced dementia in mice.

    PubMed

    Rani, Anu; Neha; Sodhi, Rupinder K; Kaur, Amanpreet

    2015-11-01

    Many studies report that heavy metals such as aluminum are involved in amyloid beta aggregation and neurotoxicity. Further, high concentration of aluminum in the brain deregulates calcium signaling which contributes to synaptic dysfunction and halts neuronal communication which ultimately leads to the development of Alzheimer's disease. Recently, diltiazem, a calcium channel blocker clinically used in angina, is reported to decrease amyloid beta production by inhibiting calcium influx, decreasing inflammation and oxidative stress. However, the probable role of this drug in aluminum chloride (AlCl3)-induced experimental dementia is yet to be explored. Therefore, the present study is designed to investigate the effect of AlCl3-induced dementia in mice. Morris water maze test and elevated plus maze were utilized to evaluate learning and memory. Various biochemical estimations including brain acetylcholinesterase activity (AChE), brain total protein, thiobarbituric acid-reactive species (TBARS) level, reduced glutathione (GSH) level, nitrate/nitrite, and superoxide dismutase (SOD) were measured. AlCl3 significantly impaired learning and memory and increased brain AChE, brain total protein, TBARS, and nitrate/nitrite and decreased brain GSH or SOD. On the other hand, treatment with diltiazem significantly reversed AlCl3-induced behavioral and biochemical deficits. The present study indicates the beneficial role of diltiazem in AlCl3-induced dementia.

  10. Interaction of theophylline, verapamil, and diltiazem on hamster diaphragm muscle force in vitro.

    PubMed

    Esau, S A

    1988-03-01

    The effect of the calcium channel blocker verapamil (5 microM) or diltiazem (5 microM) on force production and resting membrane potential (Em) was studied in the hamster diaphragm muscle. The calcium channel blockers decreased force at high frequencies of stimulation and decreased Em by 3 +/- 1 mV. The interaction of theophylline and the calcium channel blockers was also studied. When given simultaneously, the calcium channel blockers prevented the increase in force at high frequencies with theophylline at 1 mM and at all frequencies with theophylline at 0.55 mM. There was no change in Em when theophylline and calcium channel blockers were given together. Similar results were obtained by removing external calcium. The decrease in force produced by verapamil was not reversed by subsequent addition of theophylline. Theophylline did reverse the decrease in force produced by diltiazem. Verapamil reversed the increase in force at high frequencies produced by theophylline. Diltiazem reversed the force increase at low frequencies as well. These studies suggest that extracellular calcium is important in skeletal muscle contractility especially at high frequencies. Extracellular calcium is also important for the potentiation of force and the hyperpolarization of the Em produced by theophylline. The mechanism by which extracellular calcium contributes to these actions of theophylline is not known.

  11. Quality of life in patients with chronic anal fissure after topical treatment with diltiazem

    PubMed Central

    Tsunoda, Akira; Kashiwagura, Yasuharu; Hirose, Ken-ichi; Sasaki, Tadanori; Kano, Nobuyasu

    2012-01-01

    AIM: To assess the physical and mental health of fissure patients before and after topical treatment with diltiazem. METHODS: Consecutive patients were enrolled prospectively into the study. Quality of life was measured with the short-forum 36 health survey (SF-36) before and after 6-wk treatment with diltiazem. Patients scored symptoms of pain, bleeding, and irritation using numeral rating scales at the initial and follow-up visits. Fissure healing was assessed and side effects were noted. RESULTS: Fissures healed in 21 of 30 (70%) patients. There were significant reductions in the scores of pain, bleeding, and irritation after 1 wk of treatment, respectively. Four patients experienced perianal itching and one patient reported headache. When measured at baseline, pain and irritation showed a negative impact on two of the eight subscales on the SF-36, respectively (bodily pain and social functioning for pain; vitality and mental health for irritation). Repeating the SF-36 showed an improvement in bodily pain (P = 0.001). Patients whose fissures healed reported an improvement in bodily pain, health-perception, vitality, and mental health (P < 0.05). CONCLUSION: Successful treatment of chronic anal fissure with topical diltiazem leads to improvement in health-related quality of life. PMID:23494072

  12. Combination of tadalafil and diltiazem attenuates renal ischemia reperfusion-induced acute renal failure in rats.

    PubMed

    El-Sisi, Alaa E; Sokar, Samia S; Abu-Risha, Sally E; Ibrahim, Hanaa A

    2016-12-01

    Life threatening conditions characterized by renal ischemia/reperfusion (RIR) such as kidney transplantation, partial nephrectomy, renal artery angioplasty, cardiopulmonary bypass and aortic bypass surgery, continue to be among the most frequent causes of acute renal failure. The current study investigated the possible protective effects of tadalafil alone and in combination with diltiazem in experimentally-induced renal ischemia/reperfusion injury in rats. Possible underlying mechanisms were also investigated such as oxidative stress and inflammation. Rats were divided into sham-operated and I/R-operated groups. Anesthetized rats (urethane 1.3g/kg) were subjected to bilateral ischemia for 30min by occlusion of renal pedicles, then reperfused for 6h. Rats in the vehicle I/R group showed a significant (p˂0.05) increase in kidney malondialdehyde (MDA) content; myeloperoxidase (MPO) activity; TNF-α and IL-1β contents. In addition significant (p˂0.05) increase in intercellular adhesion molecule-1(ICAM-1) content, BUN and creatinine levels, along with significant decrease in kidney superoxide dismutase (SOD) activity. In addition, marked diffuse histopathological damage and severe cytoplasmic staining of caspase-3 were detected. Pretreatment with combination of tadalafil (5mg/kg bdwt) and diltiazem (5mg/kg bdwt) resulted in reversal of the increased biochemical parameters investigated. Also, histopathological examination revealed partial return to normal cellular architecture. In conclusion, pretreatment with tadalafil and diltiazem combination protected against RIR injury.

  13. Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.

    PubMed

    Carosati, Emanuele; Budriesi, Roberta; Ioan, Pierfranco; Ugenti, Maria P; Frosini, Maria; Fusi, Fabio; Corda, Gaetano; Cosimelli, Barbara; Spinelli, Domenico; Chiarini, Alberto; Cruciani, Gabriele

    2008-09-25

    With the effort to discover new chemotypes blocking L-type calcium channels (LTCCs), ligand-based virtual screening was applied with a specific interest toward the diltiazem binding site. Roughly 50000 commercially available compounds served as a database for screening. The filtering through predicted pharmacokinetic properties and structural requirements reduced the initial database to a few compounds for which the similarity was calculated toward two template molecules, diltiazem and 4-chloro-Ncyclopropyl- N-(4-piperidinyl)benzene-sulfonamide, the most interesting hit of a previous screening experiment. For 18 compounds, inotropic and chronotropic activity as well as the vasorelaxant effect on guinea pig were studied "in vitro", and for the most promising, binding studies to the diltiazem site were carried out. The procedure yielded several hits, confirming in silico techniques to be useful for finding new chemotypes. In particular, N-[2-(dimethylamino)ethyl]-3-hydroxy-2-naphthamide, N,Ndimethyl- N'-(2-pyridin-3-ylquinolin-4-yl)ethane-1,2-diamine, 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]- N,N-dimethylethanamine (carbinoxamine), and 7-[2-(diethylamino)ethoxy]-2H-chromen-2-one revealed interesting activity and binding to the benzothiazepine site.

  14. Effects of diltiazem on transmembrane potential and current of right ventricular papillary muscle of ferrets.

    PubMed

    Kanaya, S; Katzung, B G

    1984-01-01

    We studied the effects of diltiazem on electrical properties of isolated ferret right ventricular papillary muscles. By using standard microelectrode recording techniques and current clamp and voltage clamp protocols (single sucrose gap method), we measured action potential variables, depolarization-induced automaticity, slow (or second) inward current (Isi) and time-dependent and isochronal (1 sec) outward current. Resting potential was unaffected at all concentrations studied (from 2 nM-11 microM). At concentrations below 2 microM and at slow rates of stimulation (0.5 Hz), a small reduction of overshoot and prolongation of the action potential duration at 80% of full repolarization were observed. At concentrations of 2.2 microM or greater, marked use-dependent reductions of overshoot and plateau duration were observed that reversed with rest. Depolarization-induced automaticity was selectively suppressed at less negative diastolic potentials. In voltage clamp studies, peak Isi was markedly diminished over the concentration range studied (50% inhibitory concentration, 0.5 microM), but the current-voltage relation for Isi was not shifted on the voltage axis. The diminution in Isi was strongly use-dependent and voltage-dependent. Diltiazem (1.1 microM) had small effects on outward currents. Steady-state (isochronal) outward current and the time-dependent outward current were both reduced by 10 to 20% over the entire voltage range. Diltiazem is a potent inhibitor of the slow inward current in ventricular muscle. Its interaction with slow channel receptors appears to be strongly modulated by the state of the channels.

  15. Comparison of effects of isotonic sodium chloride with diltiazem in prevention of contrast-induced nephropathy.

    PubMed

    Beyazal, Hatice; Caliskan, Zuhal; Utaç, Cengiz

    2014-04-01

    Contrast-induced nephropathy (CIN) significantly increases the morbidity and mortality of patients. The aim of this study is to investigate and compare the protective effects of isotonic sodium chloride with sodium bicarbonate infusion and isotonic sodium chloride infusion with diltiazem, a calcium channel blocker, in preventing CIN. Our study included patients who were administered 30-60 mL of iodinated contrast agent for percutaneous coronary angiography (PCAG), all with creatinine values between 1.1 and 3.1 mg/dL. Patients were divided into three groups and each group had 20 patients. The first group of patients was administered isotonic sodium chloride; the second group was administered a solution that of 5% dextrose and sodium bicarbonate, while the third group was administered isotonic sodium chloride before and after the contrast injection. The third group received an additional injection of diltiazem the day before and first 2 days after the contrast injection. All of the patients' plasma blood urea nitrogen (BUN) and creatinine levels were measured on the second and seventh day after the administration of intravenous contrast material. The basal creatinine levels were similar for all three groups (p > 0.05). Among a total of 60 patients included in the study, 16 patients developed acute renal failure (ARF) on the second day after contrast material was injected (26.6%). The number of patients who developed ARF on the second day after the injection in the first group was five (25%), in the second group was six (30%) and the third group was five (25%) (p > 0.05). There was no significant difference between isotonic sodium chloride, sodium bicarbonate and isotonic sodium chloride with diltiazem application in prevention of CIN.

  16. An investigation into the stabilization of diltiazem HCl release from matrices made from aged polyox powders.

    PubMed

    Shojaee, Saeed; Asare-Addo, Kofi; Kaialy, Waseem; Nokhodchi, Ali; Cumming, Iain

    2013-09-01

    Matrices containing PEO fail to provide stable drug release profiles when stored at elevated temperatures for a period of time. The present study aims to stabilize diltiazem HCl release from matrices made from various molecular weights of polyox powders. To this end, various molecular weights of polyox with and without vitamin E (0.25, 0.5 and 1% w/w) were stored at 40°C for 0, 2, 4 and 8 weeks. The aged polyox powders were then mixed with the model drug at a ratio of 1:1 and compressed into tablets. At different time intervals, the aged polyox with vitamin E were taken out of oven and mixed with the drug (1:1 ratio) and compressed into tablets. Dissolution studies showed a significant increase in diltiazem HCl release rate to occur with increased storage time at 40°C ± 1 from tablets made from the aged polyox (no vitamin E). This was as a result of depolymerization of the aged polyox powders as compared to the fresh polyox samples. This was confirmed by differential scanning calorimetry (DSC) which showed a reduction in the melting point of the aged samples. Concentrations of vitamin E as low as 0.25% w/w was able to overcome the quick release of drug from the matrices made from aged polyox powders. DSC traces showed that the melting point of aged polyox samples containing vitamin E remained the same as that of the fresh samples. The presence of vitamin E is essential to stabilize the drug release from polyox matrices containing diltiazem HCl.

  17. Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test.

    PubMed

    Cui, X-Y; Zhao, X; Chu, Q-P; Chen, B-Q; Zhang, Y-H

    2007-02-01

    The present study was undertaken to investigate the effect of diltiazem, a L-type calcium channel blocker (CCB), on the behavior of zolpidem-treated mice in the elevated plus-maze (EPM). Atypical benzodiazepine zolpidem significantly increased the percentage of open arm entries without influencing the total entries and total distance and average speed at the dose of 5 mg/kg (p.o.). Co-administration of zolpidem (2 mg/kg, p.o.) and diltiazem (5, 10 and 20 mg/kg, p.o.) significantly increased both the time spent and arm entries in the open arms without influencing the total entries and spontaneous activity notwithstanding that zolpidem at dose up to 2 mg/kg (p.o.) and diltiazem at dose up to 20 mg/kg (p.o.) did not show any effects on mice behavior in EPM. Zolpidem also attenuated the anxiogenic effect of 1-(3-Chlorophenyl)piperazine (mCPP, 0.7 mg/kg, i.p.) and 5-hydroxytryptophan (5-HTP, 30 mg/kg, i.p.). Even though the zolpidem at 1 mg/kg and diltiazem at 5 mg/kg were ineffective on mCPP-induced anxiety, respectively, the co-administration of zolpidem (1 mg/kg, i.p.) and diltiazem (5 mg/kg, p.o.) showed inhibitory effect on mCPP-induced anxiety in mice. These results suggested that diltiazem, a L-type CCB may augment the anxiolytic-like effect of zolpidem and also indicated that calcium channel modulation maybe involved in the anxiolytic-like properties of zolpidem.

  18. [Acute generalised exanthematosus pustulosis (AGEP) due to diltiazem--a case report].

    PubMed

    Barcik, Katarzyna; Protas-Drozd, Franciszka; Weiss-Rostkowska, Wioletta; Flis, Edyta; Placek, Waldemar

    2009-08-01

    A case of a patient who developed acute generalised exanthemotosus pustulosis (AGEP) due to diltiazem therapy is presented. On the day of the admission to hospital skin changes were present on the whole body in the form of sterile spots of an erythema origin. The laboratory tests showed anaemia, leucocytosis, hypocalcaemia, increased liver enzymes and increased ESR. The skin changes were accompanied by high temperature and bad condition. On the basis of medical history, clinical picture and medical tests, AGEP was diagnosed. After the application of a general treatment with erythromycin and external preparations, the skin changes subsided completely.

  19. Effect of diltiazem on myocardial infarct size estimated by enzyme release, serial thallium-201 single-photon emission computed tomography and radionuclide angiography

    SciTech Connect

    Zannad, F.; Amor, M.; Karcher, G.; Maurin, P.; Ethevenot, G.; Sebag, C.; Bertrand, A.; Pernot, C.; Gilgenkrantz, J.M.

    1988-06-01

    Diltiazem is a calcium antagonist with demonstrated experimental cardioprotective effects. Its effects on myocardial infarct size were studied in 34 patients admitted within 6 hours after the first symptoms of acute myocardial infarction. These patients were randomized, double-blind to placebo or diltiazem (10-mg intravenous bolus followed by 15 mg/hr intravenous infusion during 72 hours, followed by 4 X 60 mg during 21 days). Myocardial infarct size was assessed by plasma creatine kinase and creatine kinase-MB indexes, perfusion defect scores using single-photon emission computed tomography with thallium-201 and left ventricular ejection fraction measured by radionuclide angiography. Tomographic and angiographic scanning was performed serially before randomization, after 48 hours and 21 days later. Groups were comparable in terms of age, sex, inclusion time and baseline infarct location and size. Results showed no difference in creatine kinase and creatine kinase-MB data between controls and treated patients, a significant decrease in the perfusion defect scores in the diltiazem group (+0.1 +/- 3.0 placebo vs -2.2 +/- 1.9 diltiazem, p less than 0.02) and a better ejection fraction recovery in the diltiazem group (-4.2 +/- 7.4 placebo vs +7.7 +/- 11.2 diltiazem, p less than 0.05). Myocardial infarct size estimates from perfusion defect scores and enzyme data were closely correlated. These preliminary results suggest that diltiazem may reduce ischemic injury in acute myocardial infarction.

  20. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem.

    PubMed Central

    Stern, J H; Kaupp, U B; MacLeish, P R

    1986-01-01

    The effect of calcium ions on the cGMP-activated current of outer segment membrane was examined by the excised-patch technique. Changes in the extracellular calcium concentration had marked effects on the cGMP-activated current, while changes in intracellular calcium concentration were ineffective. Changes in calcium concentration in the absence of cGMP had little, if any, effect on membrane conductance. These results suggest that both intracellular cGMP and extracellular calcium can directly affect the conductance underlying the light response in rod cells. The pharmacological agent l-cis-diltiazem reversibly inhibited the cGMP-activated current when applied to the intracellular side of an excised patch. When superfused over intact rod cells, l-cis-diltiazem reversibly blocked much of the normal light response. The isomer, d-cis-diltiazem, did not significantly affect either patches or intact rod cells. Thus, the light-regulated conductance has binding sites for both calcium and cGMP that may interact during the normal light response in rod cells and a site specific for l-cis-diltiazem that can be used to identify and further study the conductance mechanism. PMID:3006029

  1. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem.

    PubMed

    Stern, J H; Kaupp, U B; MacLeish, P R

    1986-02-01

    The effect of calcium ions on the cGMP-activated current of outer segment membrane was examined by the excised-patch technique. Changes in the extracellular calcium concentration had marked effects on the cGMP-activated current, while changes in intracellular calcium concentration were ineffective. Changes in calcium concentration in the absence of cGMP had little, if any, effect on membrane conductance. These results suggest that both intracellular cGMP and extracellular calcium can directly affect the conductance underlying the light response in rod cells. The pharmacological agent l-cis-diltiazem reversibly inhibited the cGMP-activated current when applied to the intracellular side of an excised patch. When superfused over intact rod cells, l-cis-diltiazem reversibly blocked much of the normal light response. The isomer, d-cis-diltiazem, did not significantly affect either patches or intact rod cells. Thus, the light-regulated conductance has binding sites for both calcium and cGMP that may interact during the normal light response in rod cells and a site specific for l-cis-diltiazem that can be used to identify and further study the conductance mechanism.

  2. Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum.

    PubMed Central

    Alfaro, M. J.; Colado, M. I.; López, F.; Martín, M. I.

    1990-01-01

    1. The effects of clonidine, nimodipine and diltiazem, on the in vitro withdrawal contracture induced by naloxone in the guinea-pig ileum obtained from morphine-dependent animals, were evaluated. 2. The in vitro incubation with clonidine (0.01, 0.1 and 1 microM), diltiazem (0.25, 0.1 and 1 microns) or nimodipine (0.05, 0.1 and 1 microns) reduced significantly the force of the contracture induced by naloxone in the morphine-dependent guinea-pig ileum. 3. The intraperitoneal administration of clonidine (0.3 mg kg-1), nimodipine (5 mg kg-1) or diltiazem (20 mg kg-1) reduced the contractile response induced by naloxone in the morphine-dependent guinea-pig ileum. 4. It is concluded that at least part of the effect of clonidine, nimodipine and diltiazem on withdrawal contractures is mediated via a peripheral, rather than a central site of action. Even though, the mechanism responsible for the effect of the calcium channel blockers differs from that of alpha 2-adrenoceptor agonists, all of the drugs tested prevented the contracture induced by naloxone in morphine-dependent guinea-pig ileum. PMID:2085717

  3. Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation.

    PubMed

    Siu, Chung-Wah; Lau, Chu-Pak; Lee, Wai-Luen; Lam, Kwok-Fai; Tse, Hung-Fat

    2009-07-01

    To compare the clinical efficacy of intravenous diltiazem, digoxin, and amiodarone for acute ventricular rate (VR) control in patients with acute symptomatic atrial fibrillation (AF) necessitating hospitalization. Randomized control trial. Acute emergency medical admission unit in a regional teaching hospital in Hong Kong. One hundred fifty adult patients with acute AF and rapid VR (>120 bpm). Patients were randomly assigned in 1:1:1 ratio to receive intravenous diltiazem, digoxin, or amiodarone for VR control. The primary end point was sustained VR control (<90 bpm) within 24 hours; the secondary end points included AF symptom improvement and length of hospitalization. At 24 hours, VR control was achieved in 119 of 150 patients (79%). The time to VR control was significantly shorter among patients in the diltiazem group (log-rank test, p < 0.0001) with the percentage of patients who achieved VR control being higher in the diltiazem group (90%) than the digoxin group (74%) and the amiodarone group (74%). The median time to VR control was significantly shorter in the diltiazem group (3 hours, 1-21 hours) compared with the digoxin (6 hours, 3-15 hours, p < 0.001) and amiodarone groups (7 hours, 1-18 hours, p = 0.003). Furthermore, patients in the diltiazem group persistently had the lowest mean VR after the first hour of drug administration compared with the other two groups (p < 0.05). The diltiazem group had the largest reduction in AF symptom frequency score and severity score (p < 0.0001). In addition, length of hospital stay was significantly shorter in the diltiazem group (3.9 +/- 1.6 days) compared with digoxin (4.7 +/- 2.1 days, p = 0.023) and amiodarone groups (4.7 +/- 2.2 days, p = 0.038). As compared with digoxin and amiodarone, intravenous diltiazem was safe and effective in achieving VR control to improve symptoms and to reduce hospital stay in patients with acute AF.

  4. Effect of diltiazem and metoprolol on left atrial appendix functions in patients with nonvalvular chronic atrial fibrillation.

    PubMed

    Karaca, Ilgin; Coşkun, Naci; Yavuzkir, Mustafa; Ilkay, Erdoğan; Dağli, Necati; Işik, Ahmet; Balin, Mehmet; Akbulut, Mehmet; Arslan, Nadi

    2007-03-01

    Thrombo-embolic events are the important cause of mortality and morbidity in patients with chronic atrial fibrillation (CAF). The origin of thromboembolism is often the left atrial appendix (LAA). Flow rate velocity (FRV) inside the LAA is the major determinant of thrombus formation. The aim of our study was to investigate the effects of diltiazem and metoprolol used for ventricular rate control on FRV of the LAA in CAF patients and thus to evaluate the positive or negative effects of these two drugs on thromboembolic events. Sixty-four patients were included in the study. All patients were suffering from CAF for more than a year. The patients were allocated to two groups according with agent used for rate control- metoprolol (Group 1; n=31) and diltiazem (Group 2; n=33). Transesophageal echocardiography was applied to all patients and LAA FRV was measured by a pulse wave Doppler in the 1/3 proximal portion of the LAA. The measurements were repeated after applying 5 mg metoprolol to Group 1 and 25 mg diltiazem to Group 2 via venous cannula. In Group 1 after metoprolol LAA flow velocity changed from 0.25 +/- 0.90 m/s to 0.25 +/- 0.10 m/s (p>0.05). In group 2 after diltiazem left atrial appendix FRV decreased from 0.21 +/- 0.9 m/s to 0.19 +/- 0.6 m/s (p>0.05). In patients with CAF metoprolol used for ventricular rate control had no effect on LAA flow velocity and the observed decrease in LAA flow rate velocity with intravenous diltiazem was insignificant.

  5. Taro corms mucilage/HPMC based transdermal patch: an efficient device for delivery of diltiazem hydrochloride.

    PubMed

    Sarkar, Gunjan; Saha, Nayan Ranjan; Roy, Indranil; Bhattacharyya, Amartya; Bose, Madhura; Mishra, Roshnara; Rana, Dipak; Bhattacharjee, Debashis; Chattopadhyay, Dipankar

    2014-05-01

    The aim of this work is to examine the effectiveness of mucilage/hydroxypropylmethylcellulose (HPMC) based transdermal patch (matrix type) as a drug delivery device. We have successfully extracted mucilage from Colocasia esculenta (Taro) corms and prepared diltiazem hydrochloride incorporated mucilage/HPMC based transdermal patches using various wt% of mucilage by the solvent evaporation technique. Characterization of both mucilage and transdermal patches has been done by several techniques such as Molisch's test, organoleptic evaluation of mucilage, mechanical, morphological and thermal analysis of transdermal patches. Skin irritation test is studied on hairless Albino rat skin showing that transdermal patches are apparently free of potentially hazardous skin irritation. Fourier transform infrared analysis shows that there is no interaction between drug, mucilage and HPMC while scanning electron microscopy shows the surface morphology of transdermal patches. In vitro drug release time of mucilage-HPMC based transdermal patches is prolonged with increasing mucilage concentration in the formulation.

  6. Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ultrasonic scalpel.

    PubMed

    Fukuda, Shoji; Nakamura, Yuji; Egi, Koso; Fujioka, Shunichiro; Nagasaka, Satoshi; Minh, Pham Ngoc; Toguchi, Koji; Wada, Takeshi; Izumi-Nakaseko, Hiroko; Ando, Kentaro; Mizoue, Tetsuya; Takazawa, Kenji; Hosaka, Shigeru; Sugiyama, Atsushi

    2016-10-01

    Direct vasodilator effects of nitroglycerin, nifedipine, cilnidipine and diltiazem on human skeletonized internal mammary artery graft harvested with ultrasonic scalpel were assessed in the presence of 0.1 or 0.2 µM of noradrenaline. Ring preparations were made of distal end section of the bypass grafts, and those dilated by acetylcholine were used for assessment. Each drug dilated the artery in a concentration-related manner (0.01-10 µM, n = 6 for each drug) with a potency of nitroglycerin > nifedipine = cilnidipine > diltiazem. These results indicate that nitroglycerin can be useful for treating internal mammary artery spasm, that clinical utility of diltiazem may not depend on its vasodilator effect on the bypass graft, and that cilnidipine as well as nifedipine will have anti-spastic action which is in the middle between those of nitroglycerine and diltiazem.

  7. Outcome Of 0.2% Glyceryltrinitrate Cream Versus 2% Diltiazem Cream In The Treatment Of Chronic Anal Fissure.

    PubMed

    Khan, Muhammad Siddique; Akbar, Ismail; Zeb, Junaid; Ahmad, Salman; Khan, Ajmal

    2017-01-01

    Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. This randomized controlled trial (RCT) was carried out in the Department of Surgical "B" unit, at Ayub Teaching Hospital, Abbottabad, Pakistan from 15th June 2012 to 15th May 2015. One hundred and eighty-four patients who visited the outpatient department for the treatment of chronic anal fissure were included in the study. They were divided into two groups with 92 patients in each group. Patients in group "A" included those patients receiving topical glyceryl trinitrate and group "B" patients were those receiving topical diltiazem cream. Out of 184 patients 66.3% were males, 33.7% were females. Mean age of the patients was 43.84±7.976 and mean duration of symptoms was 10.55±2.524. Overall outcome in terms of healing was 71.2%, among which 80.4% were from diltiazem group while 62% in glyceryl trinitrate group. Complete relief of pain was observed in 67.9%, 26.1% complained of mild pain and 5.4% complained of moderate pain. Only one patient in glyceryl trinitrate group complained with severe pain with no healing after one month of follow up. No statistical association was found between healing outcome and gender as well as age of the patients (p>0.05) although an association was found between healing outcome and duration of symptoms (p<0.05). This study shows that diltiazem has better outcome in terms of healing of chronic anal fissure and reductions in symptoms, i.e., pain compared with glyceryl trinitrate.

  8. Pharmacokinetic interactions between the orexin receptor antagonist almorexant and the CYP3A4 inhibitors ketoconazole and diltiazem.

    PubMed

    Dingemanse, Jasper; Cruz, Hans Gabriel; Gehin, Martine; Hoever, Petra

    2014-05-01

    Almorexant, a tetrahydroisoquinoline orexin receptor antagonist and first representative of a new class of compounds for the treatment of insomnia, is a substrate of the cytochrome P450 3A4 isoenzyme (CYP3A4). Two randomized two-way crossover studies were performed in healthy subjects investigating the pharmacokinetic interaction between almorexant and the CYP3A4 inhibitors ketoconazole and diltiazem. When administered as a single dose of 100 mg almorexant during steady state of ketoconazole (400 mg once daily for 14 days) or diltiazem treatment (300 mg once daily for 11 days), the exposure to almorexant was 10.5- and 3.5-fold, respectively, greater when compared with almorexant alone. Exposure to the phenol metabolites M3 and M8 increased in the presence of the CYP3A4 inhibitors, whereas that to M6 (dealkylated metabolite) decreased. Concomitant ketoconazole decreased formation of the dehydrogenated metabolite M5 and diltiazem increased concentrations of this metabolite. Higher almorexant exposure was associated with an increased incidence of typical almorexant-related adverse events such as fatigue (both studies) and somnolence (ketoconazole study only). The present results indicate that dose adaptation must be considered when almorexant would be coadministered with inhibitors of CYP3A4.

  9. Validation and Uncertainty Estimation of an Ecofriendly and Stability-Indicating HPLC Method for Determination of Diltiazem in Pharmaceutical Preparations

    PubMed Central

    Sadeghi, Fahimeh; Navidpour, Latifeh; Bayat, Sima; Afshar, Minoo

    2013-01-01

    A green, simple, and stability-indicating RP-HPLC method was developed for the determination of diltiazem in topical preparations. The separation was based on a C18 analytical column using a mobile phase consisted of ethanol: phosphoric acid solution (pH = 2.5) (35 : 65, v/v). Column temperature was set at 50°C and quantitation was achieved with UV detection at 240 nm. In forced degradation studies, the drug was subjected to oxidation, hydrolysis, photolysis, and heat. The method was validated for specificity, selectivity, linearity, precision, accuracy, and robustness. The applied procedure was found to be linear in diltiazem concentration range of 0.5–50 μg/mL (r 2 = 0.9996). Precision was evaluated by replicate analysis in which % relative standard deviation (RSD) values for areas were found below 2.0. The recoveries obtained (99.25%–101.66%) ensured the accuracy of the developed method. The degradation products as well as the pharmaceutical excipients were well resolved from the pure drug. The expanded uncertainty (5.63%) of the method was also estimated from method validation data. Accordingly, the proposed validated and sustainable procedure was proved to be suitable for routine analyzing and stability studies of diltiazem in pharmaceutical preparations. PMID:24163778

  10. Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprolol/λ-Carrageenan Complexes

    PubMed Central

    Bonferoni, Maria Cristina; Colombo, Paolo; Zanelotti, Laura; Caramella, Carla

    2014-01-01

    In this work we investigated the moving boundaries and the associated drug release kinetics in matrix tablets prepared with two complexes between λ-carrageenan and two soluble model drugs, namely, diltiazem HCl and metoprolol tartrate aiming at clarifying the role played by drug/polymer interaction on the water uptake, swelling, drug dissolution, and drug release performance of the matrix. The two studied complexes released the drug with different mechanism indicating two different drug/polymer interaction strengths. The comparison between the drug release behaviour of the complexes and the relevant physical mixtures indicates that diltiazem gave rise to a less soluble and more stable complex with carrageenan than metoprolol. The less stable metoprolol complex afforded an erodible matrix, whereas the stronger interaction between diltiazem and carrageenan resulted in a poorly soluble, slowly dissolving matrix. It was concluded that the different stability of the studied complexes affords two distinct drug delivery systems: in the case of MTP, the dissociation of the complex, as a consequence of the interaction with water, affords a classical soluble matrix type delivery system; in the case of DTZ, the dissolving/diffusing species is the complex itself because of the very strong interaction between the drug and the polymer. PMID:25045689

  11. Temperature-dependent modulation of (/sup 3/H)nitrendipine binding by the calcium channel antagonists verapamil and diltiazem in rat brain synaptosomes

    SciTech Connect

    Boles, R.G.; Yamamura, H.I.; Schoemaker, H.; Roeske, W.R.

    1984-05-01

    Binding of the dihydropyridine calcium channel antagonist (/sup 3/H)nitrendipine to an intact rat brain mitochondrial-synaptosomal fraction (P/sub 2/) was specific, saturable, temperature-dependent and of high affinity (K/sub d/ . 115-467 pM). The effects of the calcium channel antagonists verapamil and diltiazem on (/sup 3/H)nitrendipine binding and their temperature dependence were investigated. At 0 and 25 degrees C, verapamil inhibited (/sup 3/H)nitrendipine binding incompletely in a manner consistent with an allosteric modulation and nearly independent of the incubation temperature. The effects of diltiazem, however, were found to be highly temperature-dependent. At 25 and 37 degrees C, 10 microM diltiazem enhanced (/sup 3/H)nitrendipine binding to values of 140 and 200% of control, respectively. At 0 degrees C, 10 microM diltiazem inhibited (/sup 3/H)nitrendipine binding to a value of 68% of control. Analysis of saturation isotherms at steady state demonstrated that at all temperatures studied the effects of verapamil and diltiazem on (/sup 3/H)nitrendipine binding were due to alterations in the ligand dissociation constant (K/sub d/). At 25 degrees C, these alterations were mediated by changes in the rate of ligand-receptor complex dissociation. Competition studies of verapamil and diltiazem at 25 and 0 degrees C indicate that the effects of these two drugs on (/sup 3/H)nitrendipine binding are mutually exclusive. We conclude that the binding of (/sup 3/H)nitrendipine is allosterically modulated by spacially related binding sites for verapamil and diltiazem.

  12. Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation

    PubMed Central

    Wang, Yi-xi; Li, Jia-li; Wang, Xue-ding; Zhang, Yu; Wang, Chang-xi; Huang, Min

    2015-01-01

    Aim: Co-administration of diltiazem can reduce the dosage of cyclosporine (CsA) in patients with renal transplantation. In this study, we investigated how diltiazem altered the relationship between MDR1 genetic polymorphisms and CsA concentration in Chinese patients with renal transplantation. Methods: A total of 126 renal transplant patients were enrolled. All the patients received CsA (2–4 mg·kg−1·d−1), and diltiazem (90 mg/d) was co-administered to 76 patients. MDR1-C1236T, G2677T/A, and C3435T polymorphisms were genotyped. The whole blood concentration was measured using the FPIA method, and the adjusted trough concentrations were compared among the groups with different genotypes. Results: In all patients, MDR1-C1236T did not influence the adjusted CsA trough concentration. With regard to MDR1-3435, the adjusted CsA trough concentration was significantly higher in TT carriers than in CC and CT carriers when diltiazam was co-administered (58.83±13.95 versus 46.14±7.55 and 45.18±12.35 ng/mL per mg/kg, P=0.011), and the differences were not observed in patients without diltiazam co-administered. With regard to MDR1-2677, the adjusted CsA trough concentration was significantly higher in TT carriers than in GG and GT carriers when diltiazam was co-administered (61.31±12.93 versus 52.25±7.83 and 39.70±7.26 ng/mL per mg/kg, P=0.0001). The differences were also observed in patients without diltiazam co-administered (43.27±5.95 versus 35.22±7.55 and 29.54±5.35 ng/mL per mg/kg, P=0.001). The adjusted CsA trough blood concentration was significantly higher in haplotype T-T-T and haplotype T-T-C carriers than in non-carriers, regardless of diltiazem co-administered. Conclusion: MDR1 variants influence the adjusted CsA trough concentration in Chinese patients with renal transplant, and the influence more prominent when diltiazem is co-administered. PMID:25891084

  13. Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation.

    PubMed

    Wang, Yi-xi; Li, Jia-li; Wang, Xue-ding; Zhang, Yu; Wang, Chang-xi; Huang, Min

    2015-07-01

    Co-administration of diltiazem can reduce the dosage of cyclosporine (CsA) in patients with renal transplantation. In this study, we investigated how diltiazem altered the relationship between MDR1 genetic polymorphisms and CsA concentration in Chinese patients with renal transplantation. A total of 126 renal transplant patients were enrolled. All the patients received CsA (2-4 mg·kg(-1)·d(-1)), and diltiazem (90 mg/d) was co-administered to 76 patients. MDR1-C1236T, G2677T/A, and C3435T polymorphisms were genotyped. The whole blood concentration was measured using the FPIA method, and the adjusted trough concentrations were compared among the groups with different genotypes. In all patients, MDR1-C1236T did not influence the adjusted CsA trough concentration. With regard to MDR1-3435, the adjusted CsA trough concentration was significantly higher in TT carriers than in CC and CT carriers when diltiazam was co-administered (58.83±13.95 versus 46.14±7.55 and 45.18±12.35 ng/mL per mg/kg, P=0.011), and the differences were not observed in patients without diltiazam co-administered. With regard to MDR1-2677, the adjusted CsA trough concentration was significantly higher in TT carriers than in GG and GT carriers when diltiazam was co-administered (61.31±12.93 versus 52.25±7.83 and 39.70±7.26 ng/mL per mg/kg, P=0.0001). The differences were also observed in patients without diltiazam co-administered (43.27±5.95 versus 35.22±7.55 and 29.54±5.35 ng/mL per mg/kg, P=0.001). The adjusted CsA trough blood concentration was significantly higher in haplotype T-T-T and haplotype T-T-C carriers than in non-carriers, regardless of diltiazem co-administered. MDR1 variants influence the adjusted CsA trough concentration in Chinese patients with renal transplant, and the influence more prominent when diltiazem is co-administered.

  14. Influence of Organic Acids on Diltiazem HCl Release Kinetics from Hydroxypropyl Methyl Cellulose Matrix Tablets

    PubMed Central

    Sateesha, SB; Rajamma, AJ; Narode, MK; Vyas, BD

    2010-01-01

    The matrix tablets of diltiazem hydrochloride were prepared by direct compression using hydroxypropyl methyl cellulose (HPMC) and various amounts (2.5%, 5.0%, 10% and 20%) of citric acid, malic acid and succinic acid. The characterization of physical mixture of drug and organic acids was performed by Infra-red spectroscopy. An organic acid was incorporated to set up a system bringing about gradual release of this drug. The influence of organic acids on the release rate were described by the Peppas equation: M t /M∞ = Kt n and Higuchi’s equation: Q t = K1t1/2. The addition of organic acids and the pH value of medium could notably influence the dissolution behavior and mechanism of drug-release from matrices. Increasing amounts of organic acid produced an increase in drug release rate, which showed a good linear relationship between contents of organic acid and drug accumulate release (%) in phosphate buffer, pH 7.4. The drug release increased significantly (P < 0.05) with use of succinic acid in tablet formulation. Increasing amounts of succinic acid above 10% produced decreasing values of n and increasing values of k, in a linear relationship, which indicated there was a burst release of drug from the matrix. Optimized formulations are found to be stable upon 3-month study. PMID:21042476

  15. Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem.

    PubMed

    Leboeuf, J; Lamar, J C; Massingham, R; Ponsonnaille, J

    1989-12-01

    1. The electrophysiological effects of bepridil, its quaternary derivative, CERM 11888 (methylpyrrolidinium bromide) (both 2.5 mg kg-1 i.v.) and those of verapamil and diltiazem (0.2 mg kg-1 i.v.) were studied in closed chest anaesthetized dogs at doses used in clinical studies. 2. The four drugs caused a bradycardia with the following order of potency: bepridil greater than CERM 11888 greater than diltiazem greater than verapamil. 3. All the compounds slowed conduction in the AV node, increased the refractory period (RP) and decreased Wenckebach rates with the following order: verapamil much greater than diltiazem greater than bepridil greater than CERM 11888. 4. Verapamil and diltiazem did not affect conduction or the RP in atria while bepridil weakly slowed the former and markedly increased the latter. CERM 11888 caused a lengthening of RP but this was a delayed effect. 5. In the ventricle, bepridil and CERM 11888 caused a small increase in the QRS and a more pronounced increase in the RP. Both compounds increased QTc but did not modify HV. Verapamil and diltiazem had no significant effects at the ventricular level. 6. Our results confirm that the main sites of action of calcium antagonists are the SA and AV nodes. Bepridil has a broader spectrum of activity and also acts at the atrial and ventricular levels. A comparison of the effects of bepridil with those of its quaternary derivative suggests the involvement of an intracellular action in the electrophysiological effects of bepridil.

  16. Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem.

    PubMed Central

    Leboeuf, J.; Lamar, J. C.; Massingham, R.; Ponsonnaille, J.

    1989-01-01

    1. The electrophysiological effects of bepridil, its quaternary derivative, CERM 11888 (methylpyrrolidinium bromide) (both 2.5 mg kg-1 i.v.) and those of verapamil and diltiazem (0.2 mg kg-1 i.v.) were studied in closed chest anaesthetized dogs at doses used in clinical studies. 2. The four drugs caused a bradycardia with the following order of potency: bepridil greater than CERM 11888 greater than diltiazem greater than verapamil. 3. All the compounds slowed conduction in the AV node, increased the refractory period (RP) and decreased Wenckebach rates with the following order: verapamil much greater than diltiazem greater than bepridil greater than CERM 11888. 4. Verapamil and diltiazem did not affect conduction or the RP in atria while bepridil weakly slowed the former and markedly increased the latter. CERM 11888 caused a lengthening of RP but this was a delayed effect. 5. In the ventricle, bepridil and CERM 11888 caused a small increase in the QRS and a more pronounced increase in the RP. Both compounds increased QTc but did not modify HV. Verapamil and diltiazem had no significant effects at the ventricular level. 6. Our results confirm that the main sites of action of calcium antagonists are the SA and AV nodes. Bepridil has a broader spectrum of activity and also acts at the atrial and ventricular levels. A comparison of the effects of bepridil with those of its quaternary derivative suggests the involvement of an intracellular action in the electrophysiological effects of bepridil. PMID:2611495

  17. Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials.

    PubMed

    Wang, Lan; Cheng, Zhong; Gu, Ye; Peng, Dingfeng

    2015-01-01

    Currently, there is still a lack of an optimal treatment for no reflow phenomenon (NRP). We analyzed the efficacy and safety of using nondihydropyridine calcium channel antagonists (NDHP, verapamil/diltiazem) in patients suffering from NRP. Eight RCTs with 494 participants were eligible for analysis. The pooling analysis showed that intracoronary verapamil/diltiazem injection significantly decreased the occurrence of the coronary NRP (RR: 0.3, 95% CI: 0.16-0.57; P = 0.0002) and reduced corrected thrombolysis in myocardial infarction (TIMI) frame Count (WMD = -9.24, 95% CI -13.91-4.57; P = 0.0001) in patients with NRP. Moreover, verapamil/diltiazem treatment showed superiority in reducing wall motion index (WMI) compared to the control at day 1 (WMD = 0.11, 95% CI: 0.02-0.20; P = 0.02) (P < 0.05). There was also a significantly greater decline at occurrence of the major adverse cardiac events between verapamil/diltiazem and control groups (WMD: 0.4, 95% CI: 0.19-0.84; P = 0.02). However, using verapamil/diltiazem did not provide additional improvement of left ventricular ejection fraction post procedure (at 7 days, WMD, 0.1; 95% CI, -2.43-2.63; P = 0.94; at 30 days, WMD, 0.42; 95% CI, -2.09-2.92; P = 0.75). NDHP use is beneficial in attenuating NRP and reducing 6-month MACEs in patients with NRP.

  18. Estudio de la estructura logica utilizada en la ensenanza y el aprendizaje de los conceptos sobre el comportamiento de gases en el curso introductorio de quimica a nivel universitario

    NASA Astrophysics Data System (ADS)

    Costa Diaz, Agnes

    El estudio que se presenta es de caracter cualitativo, un estudio multicasos donde se estudia la estructura logica utilizada por cuatro (4) profesores universitarios que ensenan el curso introductorio de quimica, en la planificacion, presentacion y evaluacion del tema sobre el comportamiento de los gases. Se utilizaron varias fuentes de informacion como: cuestionarios de profesores y estudiantes, entrevistas, grabaciones videomagnetofonicas, materiales didacticos y una prueba conceptual, entre otros. La informacion recopilada fue analizada de acuerdo al orden logico del contenido presentado, el estilo de ensenanza del profesor, las tecnicas y estrategias utilizadas para el desarrollo de destrezas de pensamiento, el ambiente fisico en el salon de clase y los instrumentos de evaluacion y avaluo. El estudio demuestra que lo que los profesores piensan y planifican para hacer sus presentaciones no necesariamente es lo que ocurre en el salon de clases. El desarrollo de destrezas de pensamiento, que constituye una prioridad de los profesores, no se elaboran efectivamente. El uso de las estrategias de resolucion de problemas numericos predomino. La participacion del estudiante en el salon de clases fue limitada y no se logro demostrar el desarrollo de las destrezas de pensamiento deseadas. Aunque los profesores tienen su propio estilo de ensenanza, el orden logico del contenido presentado en clase fue el mismo o siguio muy de cerca el orden establecido por el libro de texto. Los profesores utilizaron preferentemente la tiza y la pizarra para sus presentaciones y la dinamica en el salon de clases fue esencialmente tradicional. Los profesores hicieron su presentacion y los estudiantes copiaron pasivamente la informacion. Las evaluaciones de los estudiantes fueron esencialmente, pruebas escritas de seleccion multiple de acuerdo con el estilo en que se les enseno. El avaluo fue casi inexistente. La prueba conceptual administrada revela un aprendizaje pobre en los conceptos mas

  19. The role of topical diltiazem in the treatment of chronic anal fissures that have failed glyceryl trinitrate therapy.

    PubMed

    Griffin, N; Acheson, A G; Jonas, M; Scholefield, J H

    2002-11-01

    The treatment of anal fissures has evolved over the last 5 years with the development of topical treatments aimed at reducing sphincter hypertonia. This is thought to improve anal mucosal blood flow and promote healing of the fissure. This study reports the use of topical diltiazem in patients with chronic anal fissures that have failed previous treatment with topical 0.2% glyceryl trinitrate (GTN). Forty-seven patients with chronic anal fissure who had previously failed at least one course of topical GTN were recruited prospectively from a single centre. Patients were instructed to apply 2 cm (approximately 0.7 g) of 2% diltiazem cream to the anal verge twice daily for eight weeks. Symptoms of pain, bleeding and itching were recorded on a linear analogue score prior to starting the cream and then repeated at 2 weekly intervals. Patients were asked to report side-effects throughout the study period. Healing of the fissure was assessed after 8 weeks of treatment. Forty-six patients completed treatment; of these, 22 had healed fissures (48%). Ten of the 24 patients with persistent fissures were symptomatically improved and wished no further treatment. Of the 14 patients who remained symptomatic, one was given a repeat course of 0.2% glyceryl trinitrate with subsequent healing of the fissure, 10 were recruited into an ongoing study involving injections of botulinum toxin into the internal anal sphincter and three were referred for surgery. This study shows that topical 2% diltiazem is an effective and safe treatment for chronic anal fissure in patients who have failed topical 0.2% GTN. The need for sphincterotomy can be avoided in up to 70% of cases.

  20. Intracellular mechanisms of verapamil and diltiazem action on striated muscle of the rabbit.

    PubMed

    Su, J Y

    1988-09-01

    Skinned fibers from striated muscle were used to study the intracellular mechanisms (contractile proteins and sarcoplasmic reticulum [SR]) of action of diltiazem (DT) and verapamil (VP) on muscle contraction. Rabbit papillary muscle (PM), and the skeletal muscles adductor magnus (AM, fast-twitch) and soleus (SL, slow-twitch) were used. The muscles were skinned by homogenization and fibre bundles for PM and single fibres for AM and SL were dissected from the homogenate and mounted on photodiode force transducers. VP (0.1-3.0 mmol/l) (and to a lesser degree DT) increased Ca2+-activated tension development of the contractile protains in PM and SL and decreased it in AM (+[4-20]%, +4%, -[14-28]%, respectively). Both drugs increased the submaximal Ca2+-activated tension development at the order of PM = SL greater than AM in a dose-dependent manner. The changes of half-maximal pCa50 at 1 mmol/l VP were 0.25, 0.25, and 0.15, respectively. For Ca2+ uptake and release from the SR, VP as well as DT (0.1-3.0 mmol/l) in the uptake phase decreased caffeine-induced tension transients in a dose-dependent fashion. At 0.01-3.0 mmol/l, the drugs directly induced Ca2+ release from the SR or enhanced caffeine-induced tension transients with the exception that in PM, DT attenuated caffeine-induced tension transients. Thus, VP and DT have similar intracellular mechanisms of action in striated muscle. Both drugs induced calcium release from the SR and increase Ca2+ sensitivity of the contractile proteins, and thus could be the underlying mechanisms for potentiating twitch tension, and inducing contracture in skeletal muscle.

  1. Preparation and in vitro Evaluation of Ethylcellulose Coated Egg Albumin Microspheres of Diltiazem Hydrochloride.

    PubMed

    Shailesh, Tp; Vipul, Pd; Girishbhai, Jk; Manish, Cj

    2010-01-01

    The aim of the present investigation was to develop sustained release ethylcellulose-coated egg albumin microspheres of diltiazem hydrochloride (DH) to improve patient compliance. The microspheres were prepared by the w/o emulsion thermal cross-linking method using different proportion of the polymer to drug ratio (1.0:1.0, 1.0:1.5 and 1.0:2.0). A 3(2) full factorial design was employed to optimize two independent variables, polymer to drug ratio (X(1)) and surfactant concentration (X(2)) on dependent variables, namely % drug loading, % drug release in 60 min (Y(60)) and the time required for 80 % drug release (t(80)) were selected as dependable variable. Optimized formulation was compared to its sustained release tablet available in market. The polymer to drug ratio was optimized to 1:1 at which a high drug entrapment efficiency 79.20% ± 0.7% and the geometric mean diameter 47.30 ± 1.5 mm were found. All batches showed a biphasic release pattern; initial burst release effect (55% DH in 1 h) and then were released completely within 6 h. In situ coating of optimized egg albumin DH microspheres using 7.5% ethylcellulose significantly reduced the burst effect and provided a slow release of DH for 8-10 h. Finally, it was concluded that ethylcellulose-coated egg albumin DH microspheres is suitable for oral SR devices in the treatment of angina pectoris, cardiac arrhythmias, and hypertension due to their size and release profile.

  2. Effect of diltiazem on skeletal muscle 3-O-methylglucose transport in bacteremic rats

    SciTech Connect

    Westfall, M.V.; Sayeed, M.M.

    1989-03-01

    This study examined whether alterations in cellular Ca2+ regulation contribute to previously observed changes in skeletal muscle sugar transport during bacteremia. Fasted male rats received saline (control) or bacteria (4 X 10(10) Escherichia coli/kg) intraperitoneally. Twelve hours later, basal and insulin-mediated 3-O-methylglucose (3MG) transport was measured in isolated soleus muscles. Measurements of 3MG transport in the presence of cytochalasin b or at a low temperature (0.5 degree C) indicated that altered sugar transport in bacteremic rat muscles was not due to nonspecific membrane permeability changes. To determine the role of Ca2+ in the pathogenesis of altered sugar transport during bacteremia, rats were treated with the Ca2+ antagonist diltiazem (DZ, 0.6-2.4 mg/kg) at various times (0, 0 + 7.5, 10 h) after saline or bacterial injection. In bacteremic rats given 2.4 mg/kg DZ at 10 h, basal and insulin-mediated transport were similar to control values. This dose of DZ had little effect on control muscles. The addition of 20 microM DZ to the incubation media did not affect basal or insulin-mediated 3MG transport in bacteremic rat muscles. Addition of the Ca2+ agonist BAY K 8644 to the incubation media had no effect on sugar transport in bacteremic rat muscles but caused alterations in control rat muscles that were comparable to those observed in bacteremia. These results suggest that alterations in Ca2+ regulation could contribute to the previously observed changes in sugar transport in skeletal muscles from bacteremic rats.

  3. Potentiation of the antiproliferative activity of MKT-077 by loperamide, diltiazem and tamoxifen.

    PubMed

    Abdul, Mansoor; Hoosein, Naseema

    2003-01-01

    MKT-077, a delocalized lipophilic cation, selectively targets cancer cells. MKT-077 has been reported to inhibit the growth of several tumor types and has undergone phase I clinical testing. We have examined the effect of MKT-077, alone and in combination with the antidiarrheal drug loperamide. Ten human cancer cell lines, four prostate (PC3, DU145, LNCaP, MDA-PCA-2B), two breast (MCF-7 and MDA-MB-231) and four colon (LoVo, Colo320DM, SW1116 and LS174t) were tested in vitro. Cells were grown to confluency prior to treatment. Loperamide potentiated the antiproliferative effect of MKT-077 in all ten cell lines, in a dose-dependent manner. The sensitivity of MDA-PCA-2B cells, the two breast and four colon cancer cell lines to MKT-077 was relatively low (>2.5 microg/ml MKT-077 required to inhibit growth by 95%). In these cell lines, 0.5-5 microg/ml (1-10 microM) loperamide caused a marked increase in the response to MKT-077. Loperamide is known to activate micro-opioid receptors at nanomolar concentrations and block voltage-gated calcium channels at micromolar doses. We found that calcium channel-blockers diltiazem and nifedipine (10-20 microg/ml), as well as tamoxifen (1.5-2.5 microg/ml) can also potentiate the growth-inhibitory effects of MKT-077. These synergistic interactions could be exploited for therapeutic benefit.

  4. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea.

    PubMed

    Kim, Younghee; Choi, Kyungho; Jung, Jinyong; Park, Sujung; Kim, Pan-Gyi; Park, Jeongim

    2007-04-01

    Pharmaceuticals are manufactured and used for specific biological functions in veterinary and human medicine. Their detection in the environment and their bioactivity have resulted in concern for potential adverse effects on non-target species. Notwithstanding recent attention for their occurrence in the environment, there are significant research gaps for existing pharmaceuticals with regard to their potential ecological consequences. In this study, the four most abundantly used pharmaceuticals in Korea, namely acetaminophen, carbamazepine, cimetidine, and diltiazem, and six sulfonamide related antibiotics, including sulfamethoxazole, sulfachlorpyridazine, sulfathiazole, sulfamethazine, sulfadimethoxine, and trimethoprim were examined for their acute aquatic toxicity employing a marine bacterium (Vibrio fischeri), a freshwater invertebrate (Daphnia magna), and the Japanese medaka fish (Oryzias latipes). In general, Daphnia was the most susceptible among the test organisms. The most acutely toxic among the chemicals tested in this study was diltiazem, with a median lethal concentration of 8.2 mg/L for D. magna. The resulting acute toxicity of these pharmaceuticals was reasonably predicted by physicochemical descriptors such as pH-dependent distribution coefficient and EHOMO-ELUMO gap. Predicted environmental concentrations (PECs) derived for the test pharmaceuticals in Korea ranged between 0.14 and 16.5 microg/L. Hazard quotients derived from PECs and predicted no effect concentrations (PNECs) for sulfamethoxazole and acetaminophen were 6.3 and 1.8, respectively, suggesting potential environmental concerns and a need for further investigation.

  5. Comparison of the effects of trimetazidine and diltiazem on exercise performance in patients with coronary heart disease. The Turkish trimetazidine study (TTS).

    PubMed

    Koylan, Nevres; Bilge, Ahmet Kaya; Adalet, Kamil; Mercanoglu, Fehmi; Büyüköztürk, Kemalettin

    2004-12-01

    A multicentre, double-blind comparative study was performed to compare the effects of trimetazidine with diltiazem on exercise performance in patients with stable angina pectoris. A total of 116 male patients with documented coronary artery disease at 11 centres were randomized into trimetazidine and diltiazem groups both including 58 men (mean age 55.1+/-8.6 years and 54.9+/-6.6 years, respectively) in a prospective, multicentre, double-blind active treatment trial. The study consisted of a two-week placebo washout period and a four-week active treatment phase. Clinical examinations and exercise tests were performed at the beginning (D0) and at the end (D28) of the active treatment. Laboratory investigations were also performed at the beginning of the washout period (D-14) and at D28. Holter recordings were done in the mid of the washout period (D-7) and D28. Both trimetazidine and diltiazem decreased the number of anginal attacks per week (p < 0.0001 for both drugs) and weekly nitrate consumption (p = 0.0008 and p < 0.0001, respectively). Both trimetazidine and diltiazem improved the recovery of anginal pain (p = 0.0188 and p = 0.0079, respectively) and maximal ST-segment depression (p = 0.0134 and p = 0.0214, respectively) but none of the drugs significantly changed the time to 1 mm ST-segment depression and ST recovery time on exercise test. Diltiazem caused a slight prolongation of PR and QRS durations (p = 0.039) on ambulatory ECG whereas trimetazidine did not change these parameters significantly. This study suggests that trimetazidine is an effective and safe alternative for diltiazem in the treatment of patients with stable angina pectoris. Although several other trials have shown that this drug can be used in combination with other antianginal drugs or instead of beta blockers or nifedipine in the symptomatic treatment of stable anginal syndromes, this study suggests that trimetazidine can be used instead of diltiazem, a well-known powerful antianginal

  6. Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging.

    PubMed

    Ismail, Basma; deKemp, Rob A; Croteau, Etienne; Hadizad, Tayebeh; Burns, Kevin D; Beanlands, Rob S; DaSilva, Jean N

    2017-01-01

    ACE inhibitors are considered first line of treatment in patients with many forms of chronic kidney disease (CKD). Other antihypertensives such as calcium channel blockers achieve similar therapeutic effectiveness in attenuating hypertension-related renal damage progression. Our objective was to explore the value of positron emission tomography (PET) imaging of renal AT1 receptor (AT1R) to guide therapy in the 5/6 subtotal-nephrectomy (Nx) rat model of CKD. Ten weeks after Nx, Sprague-Dawley rats were administered 10mg/kg/d enalapril (NxE), 30mg/kg/d diltiazem (NxD) or left untreated (Nx) for an additional 8-10 weeks. Kidney AT1R expression was assessed using in vivo [18F]fluoropyridine-losartan PET and in vitro autoradiography. Compared to shams, Nx rats exhibited higher systolic blood pressure that was reduced by both enalapril and diltiazem. At 18-20 weeks, plasma creatinine and albuminuria were significantly increased in Nx, reduced to sham levels in NxE, but enhanced in NxD rats. Enalapril treatment decreased kidney angiotensin II whereas diltiazem induced significant elevations in plasma and kidney levels. Reduced PET renal AT1R levels in Nx were normalized by enalapril but not diltiazem, and results were supported by autoradiography. Reduction of renal blood flow in Nx was restored by enalapril, while no difference was observed in myocardial blood flow amongst groups. Enhanced left ventricle mass in Nx was not reversed by enalapril but was augmented with diltiazem. Stroke volume was diminished in untreated Nx compared to shams and restored with both therapies. [18F]Fluoropyridine-Losartan PET allowed in vivo quantification of kidney AT1R changes associated with progression of CKD and with various pharmacotherapies.

  7. Memorias del tercer simposio internacional sobre economía, planificación, y políticas de los incendios forestales: problemas y enfoques comunes

    Treesearch

    Armando González-Cabán

    2009-01-01

    Estas memorias resumen el resultado de un simposio diseñado para discutir los problemas actuales que confrontan las agencias con responsabilidad para la proteccion contra incendios forestales a nivel federal y estadual en los EE.UU., al igual que agencias en la comunidad internacional. Los temas discutidos en el simposio incluyen economía del fuego, teoría y modelos...

  8. Extractive spectrophotometric methods for determination of diltiazem HCl in pharmaceutical formulations using bromothymol blue, bromophenol blue and bromocresol green.

    PubMed

    Rahman, N; Hejaz-Azmi, S N

    2000-12-01

    Three simple and sensitive extractive spectrophotometric methods have been described for the assay of diltiazem hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 415 nm for all three methods. Beer's law is obeyed in the concentration ranges 2.5-20.0, 2.5-10.0 and 2.5-12.5 microg ml(-1) with BTB, BPB and BCG, respectively. The methods have been applied to the determination of drug in commercial tablets and capsules. Results of analysis were validated statistically and through recovery studies.

  9. Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.

    PubMed

    Carosati, Emanuele; Budriesi, Roberta; Ioan, Pierfranco; Cruciani, Gabriele; Fusi, Fabio; Frosini, Maria; Saponara, Simona; Gasparrini, Francesco; Ciogli, Alessia; Villani, Claudio; Stephens, Philip J; Devlin, Frank J; Spinelli, Domenico; Chiarini, Alberto

    2009-11-12

    We studied the stereoselective behavior of 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a recently described blocker of cardiovascular L-type calcium channels that binds to the diltiazem site. Given the stereocenter at C-2 of the pyrrolidine ring, the two enantiomers were separated by chiral HPLC and, using VCD in conjunction with DFT calculations of chiroptical properties, the absolute configuration was assigned as R-(+)/S-(-). For both forms, functional, electrophysiological, and binding properties were studied and the three-dimensional superimpositions of the two enantiomers over diltiazem were obtained in silico. The significant differences observed for the two enantiomers well agreed with the experimental data, and molecular regions were hypothesized as responsible for the cardiac stereoselectivity and vascular stereospecificity.

  10. Comparison of captopril (0.5%) cream with diltiazem (2%) cream for chronic anal fissure: a prospective randomized double-blind two-centre clinical trial.

    PubMed

    Ala, S; Enayatifard, R; Alvandipour, M; Qobadighadikolaei, R

    2016-05-01

    This study compared the efficacy of topical captopril with topical diltiazem in the treatment of chronic anal fissure (CAF). Fifty patients aged between 15 and 75 years with CAF were included in a prospective randomized, double-blind clinical trial. They were randomly allocated to either captopril (0.5%) cream or diltiazem (2%) cream in a dose of 2 cm of cream on the perianal skin every 12 h for 8 weeks. The intensity of pain upon defaecation was evaluated every 10 days using a visual analogue scale. Bleeding on defaecation, pruritus and the presence of perianal irritation were also recorded before and during the trial. The average pain scores were lower in the diltiazem group on the 20th and 30th days. From day 40 to the end of the trial the average pain scores of the two groups did not differ significantly. There were no significant differences in bleeding or perianal irritation between the groups, but the incidence of pruritus was considerably higher in the captopril group, and at the end of the trial 45.8% of the patients in this group still suffered from pruritus. Topical captopril and diltiazem were found to be equally effective in the management of pain, bleeding and perianal irritation due to CAF, but due to the high incidence of pruritus observed with topical captopril this medication is not recommended for the treatment of CAF. Colorectal Disease © 2015 The Association of Coloproctology of Great Britain and Ireland.

  11. Partial lateral internal sphincterotomy versus combined botulinum toxin A injection and topical diltiazem in the treatment of chronic anal fissure: a randomized clinical trial.

    PubMed

    Gandomkar, Hossein; Zeinoddini, Atefeh; Heidari, Reza; Amoli, Hadi Ahmadi

    2015-02-01

    The aim of this study is to evaluate the effectiveness and complications associated with combined topical diltiazem cream and botulinum toxin A injection versus partial lateral internal sphincterotomy in chronic anal fissure. This study is a parallel, randomized controlled trial (using the block randomization method). This study was performed at a university hospital in Iran. Ninety-nine patients who had chronic anal fissures were included. A total of 99 patients were randomly assigned to 2 groups; the first group received combined topical diltiazem ointment (for 6 weeks) and botulinum toxin A injection (once) (n = 49), and the second group received partial lateral internal sphincterotomy (n = 50). All the patients were followed up for 1 year. The primary outcomes measured were the healing of the anal fissure and the development of incontinence as the major adverse event during the 1-year follow-up period. The overall healing rate was 65% and 94% in the botulinum toxin A-diltiazem and partial lateral internal sphincterotomy groups (p < 0.001). The patients in the partial lateral internal sphincterotomy group experienced significantly higher incontinence scores (p = 0.04) according to the Cleveland Clinic Florida-Fecal Incontinence scoring system. In patients who had chronic anal fissure for ≤12 months, no statistical difference was observed in the healing rate between the botulinum toxin A-diltiazem and partial lateral internal sphincterotomy groups (100% vs 100%). However, in the patients with longer chronic fissures, the healing rate was significantly higher in the partial lateral internal sphincterotomy group (86% [18/21] vs 23% [5/21], p < 0.001). The 1-year follow-up period, subjective definitions of itching, and lack of anorectal manometry examinations and data regarding the effect of each treatment on anal sphincter pressure at rest and contraction are the key limitations of this study. Combined botulinum toxin A injection with a topical application of

  12. Pluronic lecithin organogel (PLO) of diltiazem hydrochloride: effect of solvents/penetration enhancers on ex vivo permeation.

    PubMed

    Parhi, Rabinarayan; Suresh, Podilam; Pattnaik, Subasini

    2016-06-01

    In the present study, pluronic lecithin organogel (PLO) of diltiazem hydrochloride (DZH) was developed by taking different ratios of organic phase to aqueous phase (1:3, 1:4, and 1:5) with varying concentration of soya lecithin (20, 30, and 40 % w/w) in organic phase (isopropyl myristate, IPM) and pluronic (20, 25, and 30 % w/w) in aqueous phase, respectively, and characterized for in vitro parameters and ex vivo permeation study. The results of in vitro parameters were found to be within permissible limit and all the PLOs were physically stable at refrigeration and ambient temperature. The influence of phase ratio and different concentrations of soya lecithin on DZH release from the PLOs was found to be significant (p < 0.05), whereas the influences of different concentrations of pluronic were insignificant. The effect of different solvents/penetration enhancers viz. IPM, propylene glycol (PG), dimethyl sulphoxide (DMSO), and D-limonene, in combination and alone, on the permeation of DZH across the dorsal skin of rat was studied. Among all, formulation containing IPM (PLO6) exhibited highest flux of 147.317 μg/cm(2)/h. Furthermore, histopathology section of treated skin sample illustrated that lipid bilayer disruption was the mechanism for the DZH permeation. The above results indicated that PLO6 may serve as a promising alternative delivery system for DZH in the effective treatment of hypertension.

  13. Liquid-liquid microextraction without phase separation in a multicommuted flow system for diltiazem determination in pharmaceuticals.

    PubMed

    Sanchez, Mariana A; Rocha, Fábio R P

    2011-05-23

    Liquid-liquid microextraction without phase segmentation was implemented in a multicommuted flow system for determination of the anti-hypertensive diltiazem. The procedure was based on ion pair formation between the drug and the dye bromothymol blue at pH 3.5. The detection was performed without phase separation in a glass tube coupled to a fiber-optics spectrophotometer. The total volume of chloroform was reduced to 50 μL in comparison with 10 mL consumed in batch. A linear response was observed between 9 and 120 μmol L(-1), with a detection limit of 0.9 μmol L(-1) (99.7% confidence level). The coefficient of variation (n=10), sampling rate and extraction efficiency were estimated as 0.6%, 78 determinations per hour and 61%, respectively. About 30 μg of bromothymol blue was consumed and the waste volume was 380 μL per determination. The results for pharmaceutical samples agreed with those obtained by the reference procedure at the 95% confidence level.

  14. Transdermal delivery of Diltiazem HCl from matrix film: Effect of penetration enhancers and study of antihypertensive activity in rabbit model

    PubMed Central

    Parhi, Rabinarayan; Suresh, Padilam

    2015-01-01

    The present investigation focused on the development of Diltiazem HCl (DTH) matrix film and its characterization by in-vitro, ex-vivo and in-vivo methods. Films were prepared by solvent casting method by taking different ratios of hydroxypropyl methylcellulose K4M (HPMC K4M) and Eudragit RS100. Various parameters of the films were analyzed such as mechanical property using tensile tester, interaction study by Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric analysis (TGA), in-vitro drug release through cellulose acetate membrane, ex-vivo permeation study using abdominal skin of rat employing Franz diffusion cell, and in-vivo antihypertensive activity using rabbit model. The FTIR studies confirmed the absence of interaction between DTH and selected polymers. Thermal analysis showed the shifting of endothermic peak of DTH in film, indicating the dispersion of DTH in molecular form throughout the film. Incorporation of 1,8-cineole showed highest flux (89.7 μg/cm2/h) of DTH compared to other penetration enhancers such as capsaicin, dimethyl sulfoxide (DMSO), and N-methyl pyrrolidone (NMP). Photomicrographs of histology study on optimized formulation (DF9) illustrated disruption of stratum corneum (SC) supporting the ex-vivo results. The in-vivo antihypertensive activity results demonstrated that formulation DF9 was effective in reducing arterial blood pressure in normotensive rabbits. SEM analysis of films kept for stability study (40 ± 2 °C/75% ± 5%RH for 3 months) revealed the formation of drug crystals which may be due to higher temperature. The findings of the study provide a better alternative dosage form of DTH for the effective treatment of hypertension with enhanced patient compliance. PMID:27222758

  15. Micro-porous surfaces in controlled drug delivery systems: design and evaluation of diltiazem hydrochloride controlled porosity osmotic pump using non-ionic surfactants as pore-former.

    PubMed

    Adibkia, Khosro; Ghanbarzadeh, Saeed; Shokri, Mohammad Hosein; Arami, Zahra; Arash, Zeinab; Shokri, Javad

    2014-06-01

    The major problem associated with conventional drug delivery systems is unpredictable plasma concentrations. The aim of this study was to design a controlled porosity osmotic pump (CPOP) of diltiazem hydrochloride to deliver the drug in a controlled manner. CPOP tablets were prepared by incorporation of drug in the core and subsequent coating with cellulose acetate as semi-permeable membrane. Non-ionic surfactants were applied as pore-formers as well. The effect of pore-formers concentration on the in vitro release of diltiazem was also studied. The formulations were compared based on four comparative parameters, namely, total drug released after 24 h (D24 h), lag-time (tL), squared correlation coefficient of zero order equation (RSQzero) and mean percent deviation from zero order kinetic (MPDzero). Results of scanning electron microscopy studies exhibited formation of pores in the membrane from where the drug release occurred. It was revealed that drug release rate was directly proportional to the concentration of the pore-formers. The value of D24 h in the formulations containing Tween 80 (10%) and Brij 35 (5%) were found to be more than 94.9%, and drug release followed zero order kinetic (RSQzero > 0.99 and MPDzero < 8%) with acceptable tL (lower than 1 h).

  16. The impact of genetic polymorphisms, diltiazem, and demographic variables on everolimus trough concentrations in lung transplant recipients.

    PubMed

    Schoeppler, Kelly E; Aquilante, Christina L; Kiser, Tyree H; Fish, Douglas N; Zamora, Martin R

    2014-05-01

    Everolimus (EVR) has inter-individual pharmacokinetic (PK) variability and a narrow therapeutic index. The study objective was to determine whether genetic polymorphisms, co-medications, and/or demographic variables accounted for inter-individual variability in EVR PK in lung transplant recipients (LTxR). LTxR were genotyped for ABCB1 c.1236C>T, ABCB1 c.2677G>T/A, ABCB1 c.3435C>T, CYP3A4*1B, CYP3A5*3, CYP2C8*2/*3/*4, and pregnane X receptor (NR1I2) c.44477T>C, c.63396C>T, c.69789A>G polymorphisms. The primary outcome was the difference in dose-adjusted EVR levels (EVR L/D) between ABCB1 diplotype groups (2 vs. 1 vs. 0 copies of the 1236C/2677G/3435C haplotype). Sixty-five LTxR were included. There was no significant difference in EVR L/D between ABCB1 CGC diplotype groups (CGC/CGC = 2.4 ± 1.1 [n = 9] vs. CGC/XXX = 2.5 ± 1.7 [n = 36] vs. XXX/XXX = 2.7 ± 1.7 ng/mL per mg/d [n = 20]; p = 0.9). CYP3A5*3, CYP3A4*1B, CYP2C8*3/*4, and NR1I2 polymorphisms were not associated with EVR L/D. EVR L/D was 3.4 ± 1.7 in LTxR receiving diltiazem (DILT) vs. 1.8 ± 1.1 ng/mL per mg/d in LTxR not receiving DILT (p <0.001). Demographic variables, including cystic fibrosis, were not associated with EVR PK. DILT use increased EVR L/D, but selected polymorphisms in ABCB1, CYP3A5, CYP3A4, CYP2C8, and NR1I2 did not affect EVR L/D in LTxR. Genotyping LTxR for these polymorphisms is unlikely to aid clinicians in optimizing EVR therapy. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. A novel micellar per aqueous liquid chromatographic method for simultaneous determination of diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum.

    PubMed

    Li, Ning; Li, Chun-lan; Lu, Ning-wei; Dong, Yu-ming

    2014-09-15

    A novel micellar per aqueous liquid chromatographic method was investigated to simultaneously determine diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum. Separation and determination of the analytes were performed on a Pinnacle II Cyano column as the stationary phase using the mobile phase consisted of aqueous solution (4.15×10(-2) mol/L sodium dodecyl sulfate and 0.02 mol/L sodium dihydrogen phosphate) with 10% (v/v) of 1-propanol at pH 7.0. This method was validated by linearity, lower limit of quantification, extraction recovery, stability, precision, and accuracy. The main analytical parameters were linearity (r>0.9950), intra- and inter-day precisions (intra-day RSD 2.2-3.5%, and inter-day RSD 3.7-9.5%), lower limit of quantification (20 ng mL(-1) for isosorbide mononitrate, metoprolol tartrate and diltiazem hydrochloride). The extraction recovery was 63.3% (0.1 μg/mL), 65.6% (1.0 μg/mL), and 69.5% (25 μg/mL) for isosorbide mononitrate; 65.1% (0.1 μg/mL), 69.5% (1.0 μg mL) and 73.5% (2.5 μg/mL) for metoprolol tartrate; 67.1% (0.1 μg/mL), 68.8% (1.0 μg/mL) and 73.8 % (2.5 μg/mL) for diltiazem hydrochloride. The relative error of stability was <6.4% at the room temperature for 24h, <3.8% at 4 °C for 1 week, <4.6% at -20 °C for 1 month, and <6.7% for freeze/thaw cycles (n=3). The results indicated that the proposed method was rapid, sensitive, and accurate for determination of the three antianginal drugs in human serum. The possible separation mechanism of the method was also discussed, and a model of separation mechanism for the analytes was established.

  18. [Parenting Information: Teenagers. Informacion Para los Padres: Sobre los Jovenes.

    ERIC Educational Resources Information Center

    Moreno, Steve

    These four booklets are devoted specifically to the concerns of parents and their teenage children and are part of a series of 22 booklets designed specifically to help parents understand their children and help them to learn. "Parents--Learn about Your Teenager" (booklet #6) explains the changes which occur during the teen years and the…

  19. L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.

    PubMed

    Budriesi, Roberta; Cosimelli, Barbara; Ioan, Pierfranco; Ugenti, Maria Paola; Carosati, Emanuele; Frosini, Maria; Fusi, Fabio; Spisani, Raffaella; Saponara, Simona; Cruciani, Gabriele; Novellino, Ettore; Spinelli, Domenico; Chiarini, Alberto

    2009-04-23

    The research of compounds with L-type calcium channels (LTCCs) blocking activity continued with heterocyclic compounds containing the 1,2,4-oxadiazol-5-one ring. For a series of 22 new derivatives of 3-aryl-4[(Z)-(1-methyl-2-alkylsulphanyl-vinyl)][1,2,4]oxadiazol-5(4H)-ones, which represent the "frozen" open chain counterpart of the cyclic aryl-thiazinooxadiazolones previously examined, we report here the synthesis and the characterization as LTCC blockers, evaluated on isolated tissues of guinea pig. The most interesting compound, 8b, was tested also on L-type calcium current recorded in isolated rat tail artery myocytes. Overall, six compounds were more potent than diltiazem, and binding assays confirmed the direct interaction with the benzothiazepine binding site. As the cyclic aryl-thiazinooxadiazolones, p-bromine substituted compounds were generally more potent than the corresponding p-chlorine ones. A saturated or unsaturated alkyl chain or a bulky group at the sulfur atom were detrimental to the potency, while the compounds with S-methyl groups, i.e., thioether (8b), sulfoxide (16a,b), and sulfone (17b), gave the best results.

  20. Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study.

    PubMed

    Pasantes-Morales, Herminia; Quiroz, Hugo; Quesada, Octavio

    2002-09-01

    The purpose of this study to assess the effect of the formula taurine/diltiazem/vitamin E on the progression of visual field loss in retinitis pigmentosa. A double blind, placebo controlled study in 62 patients: visual field threshold values were obtained in a Humphrey Field Analyzer from center (30 degrees) and periphery (30-60 degrees), every 4 months during 3-year follow-up. Data were analyzed by univariate regression, with slopes obtained from the best fit lines. Based on slope values, three groups of patients were identified as those showing negative, positive, or zero slope: > or = 1 to < or = +1. In controls (32 patients), at central area, the distribution in negative, zero, or positive slope was, respectively, 16 (50%), 11 (35%), and 5 (15%). In the treated group (30 patients) this distribution was 6 (20%) negative, 17 (53%) zero, and 7 (23%) positive slope. In periphery, 16 control patients were distributed as 11 (69%) negative, 4 (25%) zero, and 1 (6%) positive slope. In the treated group (17 patients), the distribution was opposite: 1 (6%) negative, 7 (41%) zero, and 9 (53%) positive slope. Nineteen patients receiving treatment up to 6 years showed similar distribution by slope values. Eight out of 9 patients switched from placebo (2 years) to treatment (2-3 years), showed improving changes in their slope values. A beneficial effect of the treatment decreasing the rate of visual field loss was observed, likely through a protective action from free radical reactions in affected photoreceptors.

  1. Stability of Atenolol, Clonazepam, Dexamethasone, Diclofenac Sodium, Diltiazem, Enalapril Maleate, Ketoprofen, Lamotrigine, Penicillamine-D, and Thiamine in SyrSpend SF PH4 Oral Suspensions.

    PubMed

    Polonini, Hudson C; Loures, Sharlene; Lima, Luis Claudio; Ferreira, Anderson O; Brandão, Marcos Antônio F

    2016-01-01

    The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients compounded in oral suspensions using SyrSpend SF PH4 (atenolol 1.0 and 5.0 mg/mL, clonazepam 0.2 mg/mL, dexamethasone 1.0 mg/mL, diclofenac sodium 5.0 mg/mL, diltiazem 12.0 mg/mL, enalapril maleate 1.0 mg/mL, ketoprofen 20.0 mg/mL, lamotrigine 1.0 mg/mL, penicillamine-D 50.0 mg/mL, thiamine 100 mg/m) and stored both at controlled refrigerated (2°C to 8°C) and room temperature (20°C to 25°C). Stability was assessed by means of measuring percent recovery at varying time points throughout a 90-day period. The quantification of the active pharmaceutical ingredients was performed by a stability-indicating, high-performance liquid chromatographic method. The beyond-use date of the products was found to be at least 90 days for all suspensions (except atenolol 1 mg/mL, which was stable up to 60 days), both for controlled refrigerated temperature and room temperature. This confirms that SyrSpend SF PH4 is a stable suspending vehicle for compounding with a broad range of different active pharmaceutical ingredients.

  2. Novel buccal adhesive tablets using Aloe vera L and Sinapis alba--a promising option for improved bioavailability of diltiazem hydrochloride.

    PubMed

    Sudhakar, Yajaman; Bandyopadhyay, A K

    2008-01-01

    In the current investigation, white mustard mucilage from whole seeds of Sinapis alba was evaluated for its physical properties and compared with the other mucoadhesive polymers such as hydroxy propyl methylcellulose 5Cps and Carbopol 934P. Further, methanol precipitable solids from whole leaves of Aloe Vera L were used as permeation enhancer. To achieve improved bioavailability of diltiazem, novel buccal adhesive tablets (NBATs) in cup and core fashion designed to achieve unidirectional release towards mucosa were prepared in a three-stage process using specially fabricated punches. The adhesive cups were studied for its shear, tensile, and peel strengths by specially designed apparatus using excised ruminant and porcine buccal mucosa as model substrates. Ex vivo permeation studies in a Franz diffusion cell were conducted through porcine buccal mucosa. Fourier transform infrared spectroscopy studies and differential scanning calorimetry thermographs showed no remarkable interactions. Histopathological studies showed no remarkable damage of buccal mucosa by the NBATs. In vivo studies were conducted on anaesthetized male New Zealand albino rabbits, estimated by reversed-phase high-performance liquid chromatography, and the pharmacokinetics were compared with the oral and intravenous bolus injection. NBATs exhibited a Cmax 74.6 ng/mL, Tmax 3.5 h, t(1/2) 4.36 h. The NBATs prevented salivary scavenging effect and exhibited 82.1% bioavailability.

  3. Avisos de salud sobre el PFOA y PFOS en el agua potable

    EPA Pesticide Factsheets

    La EPA estableció avisos de salud sobre el ácido perfluorooctanoico (PFOA) y el sulfonato de perfluorooctano (PFOS) para proporcionar información a los operadores de sistemas de agua potable y funcionarios estatales, tribales y locales sobre los riesgos de

  4. The influence of the copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels.

    PubMed

    Díez-Peña, Eva; Frutos, Paloma; Frutos, Gloria; Quijada-Garrido, Isabel; Barrales-Rienda, José Manuel

    2004-04-20

    A series of poly[(N-isopropylacrylamide)-co-(methacrylic acid)] (P[(N-iPAAm)-co-(MAA)]) hydrogels was investigated to determine the composition that exhibits a better pH-modulated release of diltiazem hydrochloride (DIL.HCl). For this purpose hydrogel slabs were loaded with DIL.HCl by the immersion method, and its release under acidic medium (0.1N HCl, pH 1.2) and in phosphate buffer pH 7.2, using United States Pharmacopeia (USP) 24 Apparatus 1, was investigated. According to the results from the slabs, copolymers with 85% mol N-iPAAm content were selected to prepare tablets with different particle size. The effect of pH and particle size changes on DIL.HCl release from these last hydrogel tablets was investigated by a stepwise pH variation of the dissolution medium. The amount of DIL.HCl released from high N-iPAAm content copolymer slabs under acidic pH medium was not only very low but it was also released at a slow rate. In the 85% N-iPAAm tablets, significant differences between and within release profiles were found as a function of particle size and pH, respectively. A relationship between particle size and release rate has been found. The lower DIL.HCl release at acidic pH from enriched N-iPAAm copolymers is interpreted by a cooperative thermal- and pH-collapse. Although for the whole range of copolymer composition a dependence of the equilibrium of swelling on the pH was found, DIL.HCl release experiments indicated that hydrogels with 85% mol N-iPAAm are the more adequate to be used for modulated drug delivery systems. Additionally, the particle size of the tablet can be used to tailor the release rate.

  5. Study of effect of excipient source variation on rheological behavior of diltiazem HCl-HPMC wet masses using a mixer torque rheometer.

    PubMed

    Chatlapalli, Ramarao; Rohera, Bhagwan D

    2002-05-15

    In the wet massing of powders and powder blends, the rheological behavior of the wet powder masses not only plays a critical role in the unit process but also influences the attributes of the product. The physical properties of the powder excipients, such as particle size and size distribution, shape, surface area, bulk and tapped density and surface morphology, are a major source of variability in the rheological behavior of wet powder masses and the quality attributes of the final product. The objective of the present investigations was to study the rheological behavior of wet masses containing hydroxypropyl methylcellulose (HPMC) obtained from two sources (Methocel from Dow and Pharmacoat from Shin-Etsu) using a mixer torque rheometer. In order to simulate a real formulation, diltiazem HCl (DTZ) (40% loading) was used as part of the substrate powder mass. Hydroxypropyl cellulose (HPC) was used as the binder. Since HPMC is water-soluble, isopropyl alcohol (IPA) was used as the wet massing liquid. The rheological behavior of the wet powder masses was studied as a function of mixing time and amount of wet massing liquid (IPA). The rheological profiles obtained for DTZ-Methocel and DTZ-Pharmacoat exhibited same magnitude for mean torque, however, for DTZ-Pharmacoat the peak was more extended than that for DTZ-Methocel. The extended peak for DTZ-Pharmacoat indicated that the wet mass will stay suitable during the process for larger quantities of the wet massing liquid before turning into paste and becoming unsuitable for the process as compared with the DTZ-Methocel system. The mixing kinetics of the two powder systems appeared to be quite different. These differences in the rheological behavior of the wet masses may be attributed to the difference in the particulate and surface properties of the two HPMCs. Some of the properties of the two HPMCs, such as particle size and size distribution, surface area, surface morphology and DSC thermograms, explain the difference

  6. The Meanings of Astronomical Observation: An Analysis on the Basis of Relationship with Knowledge. (Spanish Title: Los Sentidos de la Observación Astronómica: un Análisis sobre la Base de la Relación con el Saber.) Os Sentidos da Observação Astronômica: Uma Análise com Base na Relação com o Saber

    NASA Astrophysics Data System (ADS)

    Klein, Alberto Eduardo; de Mello Arruda, Sergio; Meneghello Passos, Marinez; Vinicius Domenes Zapparoli, Ferdinando

    2010-12-01

    This article presents results of a research which aimed to understand the meanings that people construct for astronomical observation. The subjects, students and school teachers, initially received some instruction on how to view astronomical objects through the telescope. After the observation was realized, they were interviewed. The data analysis allowed the creation of 12 categories, later interpreted on the basis of relationship with knowledge (relation to the world, with himself and with others), as presented by Bernard Charlot. Este artículo presenta los resultados de una investigación que tuvo como objetivo comprender los sentidos que las personas construyen para la observación astronómica. Los sujetos, los estudiantes y maestros de escuela, recibieron inicialmente algunas instrucciones sobre cómo ver los objetos astronómicos a través del telescopio. Al término de la observación, fueron entrevistados. El análisis de datos permitió la creación de 12 categorías que más tarde fueron interpretadas sobre la base de la relación con el conocimiento (relación con el mundo, consigo mismo y con los demás), tal como presentado por Bernard Charlot. Este artigo apresenta resultados de uma pesquisa que objetivou entender quais os sentidos que as pessoas constroem para a observação astronômica. Os sujeitos da pesquisa, estudantes e professores do ensino médio, receberam inicialmente alguma instrução sobre como visualizar os objetos astronômicos através do telescópio. Após a realização da observação, eles foram entrevistados. A análise dos dados permitiu a elaboração de 12 categorias que foram posteriormente interpretadas com base nas relações com o saber (relação com o mundo, consigo mesmo e com o outro), conforme apresentadas por Bernard Charlot.

  7. Dependence of copolymer composition, swelling history, and drug concentration on the loading of diltiazem hydrochloride (DIL.HCl) into poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels and its release behaviour from hydrogel slabs.

    PubMed

    Sousa, Ricardo G; Prior-Cabanillas, Alberto; Quijada-Garrido, Isabel; Barrales-Rienda, José M

    2005-02-16

    The loading of an antihypertensive cationic drug, diltiazem hydrochloride (DIL.HCl), into poly(N-isopropylacrylamide) [P(N-iPAAm)], poly(methacrylic acid) [P(MAA)], and their poly[(N-isopropylacrylamide)-co-(methacrylic acid)] P[(N-iPAAm)-co-(MAA)] hydrogels as well as their release behaviour have been investigated. For this purpose, two series of hydrogels have been tested, one previously soaked under acidic pH (treated hydrogels) and the other from the synthesis and washed in deionized water (untreated hydrogels). For the drug loading, these two series of hydrogels have been soaked in drug solutions with different concentrations. DIL.HCl amounts loaded by the gels as well as swelling degrees as a function of both hydrogel composition and DL.HCl concentration in the loading solution have been analyzed. Due to the interactions among DIL.HCl and the MAA group, "untreated" enriched MAA copolymer hydrogels present the highest drug load and loading efficiency. A DIL.HCl concentration of 320 microm/mL has been employed to load copolymers for release experiments, because for this concentration, hydrogels reach relative high drug load with a still high efficiency of loading. Release has been tested in three media, namely, fresh water (Milli-Q grade, pH 7.0), 0.1 N hydrogen chloride (pH 1.2), and a phosphate buffer (pH 7.0). In general, release is lower in fresh water and acidic media than in phosphate buffer. To explain these results, the effect of temperature, medium, and composition on the pH and thermo sensitivity of the hydrogels as well as the diltiazem-polymer interactions have been taken into account.

  8. [Parenting Information: Drugs. Informacion Para los Padres: Sobre las Drojas.

    ERIC Educational Resources Information Center

    Moreno, Steve

    These two booklets provide basic information about drugs and drug abuse and are part of a series of 22 booklets, designed specifically to help parents understand their children and help them to learn. "Let's Talk about Drug Abuse," (booklet #18), reviews foreign substances or drugs young people are often exposed to (i.e., tobacco,…

  9. Información general sobre los mosquitos

    EPA Pesticide Factsheets

    Una consecuencia más importante de algunas picaduras de mosquitos es la trasmisión de ciertas enfermedades graves como el paludismo, la fiebre del dengue y varias formas de encefalitis, que incluyen el virus del Nilo occidental.

  10. Estabilidad de los modelos de Heggie y Ramamani

    NASA Astrophysics Data System (ADS)

    Muzzio, J. C.; Vergne, M. M.; Wachlin, F. C.; Carpintero, D. D.

    Los modelos de Heggie y Ramamani de satélites galácticos en órbitas circulares se basan en una teoría aproximada, por lo que es importante verificar su estabilidad mediante simulaciones numéricas. En esta forma, hemos logrado mostrar que son estables sobre intervalos de tiempo mucho mayores que los que lograron los propios autores de los modelos. Por otra parte, dado que hemos mostrado que el caos es significativo en estos modelos, son un sistema ideal para investigar si, pese a ello, se mantienen estacionarios. Nuestras simulaciones numéricas muestran que, pese al caos, la estacionariedad se mantiene sobre intervalos de centenares de tiempos de cruce del sistema, mucho mayores que los tiempos de Liapunov característicos de sus movimientos caóticos.

  11. El problema de estabilidad de los sistemas Hamiltonianos multidimensionales

    NASA Astrophysics Data System (ADS)

    Cincotta, P. M.

    Se revisarán los aspectos básicos del problema de estabilidad de sistemans Hamiltonianos N-dimensionales, haciendo especial énfasis en los posibles mecanismos que dan lugar a la aparición de ``caos": overlap de resonancias, difusión de Arnol'd y otros procesos difusivos alternativos. Se mencionarán los aspectos aún no resueltos sobre la estabilidad de los sistemas con N > 2. Finalmente, se discutirá cuáles de estos mecanismos podrían tener alguna relevancia en la dinámica de sistemas estelares y planetarios.

  12. Memories of Astronomy Education in Brazil: Clippings from the Discourses of Interviewed Researchers on the Subject. (Spanish Title: Memorias de la Educación en Astronomía en Brasil: Recortes de los Discursos de Investigadores Entrevistados Acerca del Tema ) Memórias da Educação em Astronomia no Brasil: Recortes a Partir das Falas de Pesquisadores Entrevistados sobre o Tema

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Nardi, Roberto

    2014-12-01

    This paper presents a historical retrospective concerning data from a research in Astronomy Education in Brazil, after 1973. It was organized on the basis of the speech analysis of national researchers considered references in this field by their peers. Furthermore, it was elaborated on the basis of other studies from the areas of Science Education, Physics and Astronomy. This historical overview was developed in order to facilitate understanding of the contexts in which the interviewed researchers have developed professionally. Moreover, we attempted to recover the memory of the growing field of research in Astronomy Education in the country. We believe that the history presented can help those trying to understand the past in an attempt to resolve current and future demands. Se presenta en este artículo una retrospectiva histórica referente a datos provenientes de la investigación en enseñanza de la astronomía en el Brasil, después de 1973, organizada sobre la base del análisis de los discursos de los investigadores nacionales considerados referencias en este campo, y también en la lectura de las publicaciones en las áreas de Enseñanza de las Ciencias, Física y Astronomía. Este repaso histórico se desarrolló con el fin de facilitar la comprensión de los contextos en los que los investigadores entrevistados se han desarrollado profesionalmente. Por otra parte, se intentó recuperar la memoria del creciente campo de la investigación en Educación en Astronomía en el país. Creemos que el relato presentado puede contribuir a quien trata de comprender el pasado, en un intento de resolver las demandas actuales y futuras. Relata-se neste artigo uma retrospectiva histórica referente a dados provenientes de pesquisa em Educação em Astronomia no país, pós 1973, organizada com base na análise das falas de pesquisadores considerados referências nacionais nesse campo, como também na leitura de publicações das áreas de ensino de Ciências, F

  13. Memorias del segundo simposio internacional sobre políticas, planificación y economía de los programas de protección contra incendios forestales: una visión global; 2004 Abril 19–22; Córdoba, España

    Treesearch

    Armando González-Cabán

    2008-01-01

    Estas memorias resumen el resultado de un simposio diseñado para discutir los problemas actuales que confrontan las agencias con responsabilidad para la protección contra incendios forestales a nivel federal y estadual en los EE.UU., al igual que agencias en la comunidad internacional. Los temas discutidos en el simposio incluyen economía del fuego, teoría y modelos...

  14. Sobre el estado evolutivo de β Pictoris

    NASA Astrophysics Data System (ADS)

    Brunini, A.; Benvenuto, O. G.

    Desde el descubrimiento de fuertes excesos infrarrojos en β Pictoris, esta estrella ha sido muy estudiada y es considerada candidata a poseer un sistema planetario propio. β Pic está rodeada de un disco asimétrico de polvo que se observa de canto y que esta vacío a distancias <= 40 AU. Esto se considera una fuerte evidencia en favor de la presencia de (al menos) un planeta gigante. Recientemente se han observado líneas de material circunestelar que se han interpretado como consecuencia de la caída de objetos cometarios sobre esta estrella. Recientemente se ha utilizado la existencia del disco de polvo para atribuir una edad corta (pre - secuencia principal) a βPic. Sin embargo, la evaporación de estos cometas provee suficiente polvo como para explicar la presencia del disco observado sin necesidad de edades cortas. En este trabajo mostramos que la comparación entre la tasa de impactos cometarios estimada en el Sistema Solar para diferentes etapas de su evolución y los datos observados en β Pic indica edades avanzadas para β Pic. Esta estimación debe tomarse con cautela ya que depende de la estructura de los sistemas planetarios. Además mostramos que, desde el punto de vista de la evolución estelar y con las incertezas presentes en la luminosidad y la temperatura efectiva, existe un continuo de edades posible para β Pic. Sin embargo, empleando los datos provenientes de los flujos cometarios encontramos que una edad prolongada es consistente con ambos tratamientos.

  15. Memorias del cuarto simposio internacional sobre políticas, planificación y economía de los incendios forestales: cambio climático e incendios forestales; 2012 noviembre 5–11; Ciudad de México, México

    Treesearch

    Armando González-Cabán

    2013-01-01

    Trabajos IndividualesEstas memorias resumen el resultado de un simposio diseñado para discutir los problemas actuales que confrontan las agencias con responsabilidad para la protección contra incendios forestales a nivel federal y estadual en los EE.UU., al igual...

  16. Hoja informativa sobre la Agenda de Acción EJ 2020

    EPA Pesticide Factsheets

    Página principal de la hoja informativa sobre la Agenda de Acción EJ 2020 de la Agencia de Protección Ambiental de EE.UU. que delinea el plan estratégico de justicia ambiental de la agencia para los próximos cuatro años.

  17. Preparación de los adultos mayores en los Estados Unidos para hacer frente a los desastres naturales: encuesta a escala nacional*

    PubMed Central

    Al-rousan, Tala M.; Rubenstein, Linda M.; Wallace, Robert B.

    2015-01-01

    Objetivos. Nos propusimos determinar el grado de preparación frente a los desastres naturales de los adultos mayores en los Estados Unidos y evaluar los factores que pueden afectar negativamente la salud y la seguridad durante este tipo de incidentes. Métodos. Obtuvimos una muestra de adultos de 50 años en adelante (n = 1 304) de la encuesta del 2010 del Estudio de la Salud y la Jubilación (HRS por su sigla en inglés). La encuesta recogió datos sobre las características demográficas generales, el estado de discapacidad o las limitaciones funcionales, y también sobre factores y comportamientos relacionados con la preparación frente a los desastres. Calculamos una puntuación global de preparación mediante indicadores individuales a fin de evaluar el grado de preparación general. Resultados. La media de la edad de los participantes (n = 1 304) fue de 70 años (desviación estándar [DE] = 9,3). Solo 34,3% informaron que habían participado en un programa formativo o que habían leído materiales sobre la preparación para los desastres. Casi 15% indicaron que usaban dispositivos médicos eléctricos que podían correr riesgo de no funcionar si se interrumpiera el suministro eléctrico. La puntuación de preparación indicó que la edad más avanzada, la discapacidad física y el menor nivel de escolaridad y de ingresos se asociaban independiente y significativamente a un grado de preparación general inferior. Conclusiones. A pesar de la mayor vulnerabilidad ante los desastres y del número cada vez mayor de adultos mayores en los Estados Unidos, muchos de los problemas sustanciales que encontramos son remediables y requieren atención en los sectores de la sociedad dedicados a la atención clínica, a la salud pública y al manejo de situaciones de emergencia.

  18. Un analisis de la influencia de las fricciones de los campos no militares sobre las fricciones del campo militar presentes en la operacion de rescate de rehenes Chavin de Huantar (An Analysis of the Influence that Friction in Non-Military Fields of Action Had Upon Military Friction in the Hostage Rescue Operation Chavin de Huantar)

    DTIC Science & Technology

    2012-05-16

    esta AO, es decir, la cercanía al gobierno nacional y al mismo Presidente de la Republica , la cobertura directa de los más de ochenta medios de...colombiano Cesar Gaviria, a fin de obtener respaldo a su estrategia y manejo de la crisis. Posteriormente, con su visita a Republica Dominicana con el...de la guerra como unidad de mando fueron escrupulosamente observados desde el nivel de gobierno, con el Presidente de la Republica ejerciendo el

  19. Comprension de los conceptos de los enlaces ionico y covalente en estudiantes universitarios del primer curso de quimica general

    NASA Astrophysics Data System (ADS)

    Ballesteros Benavides, Maria Elvira

    participantes no lograron diferenciar los dos enlaces quimicos. Esto implica que reflexionemos sobre la necesidad de revisar tanto las competencias cognoscitivas como la forma de ensenar quimica en el salon de clase. Recomendamos indagar y dar importancia al conocimiento previo de los estudiantes, enfatizar la ensenanza de los conceptos y propiciar el aprendizaje con significado.

  20. Los Alamos National Laboratory.

    ERIC Educational Resources Information Center

    Hammel, Edward F., Jr.

    1982-01-01

    Current and post World War II scientific research at the Los Alamos National Laboratory (New Mexico) is discussed. The operation of the laboratory, the Los Alamos consultant program, and continuation education, and continuing education activities at the laboratory are also discussed. (JN)

  1. Los Alamos National Laboratory.

    ERIC Educational Resources Information Center

    Hammel, Edward F., Jr.

    1982-01-01

    Current and post World War II scientific research at the Los Alamos National Laboratory (New Mexico) is discussed. The operation of the laboratory, the Los Alamos consultant program, and continuation education, and continuing education activities at the laboratory are also discussed. (JN)

  2. Stockpile Stewardship: Los Alamos

    ScienceCinema

    McMillan, Charlie; Morgan, Nathanial; Goorley, Tom; Merrill, Frank; Funk, Dave; Korzekwa, Deniece; Laintz, Ken

    2016-07-12

    "Heritage of Science" is a short video that highlights the Stockpile Stewardship program at Los Alamos National Laboratory. Stockpile Stewardship was conceived in the early 1990s as a national science-based program that could assure the safety, security, and effectiveness of the U.S. nuclear deterrent without the need for full-scale underground nuclear testing. This video was produced by Los Alamos National Laboratory for screening at the Lab's Bradbury Science Museum in Los Alamos, NM and is narrated by science correspondent Miles O'Brien.

  3. Stockpile Stewardship: Los Alamos

    SciTech Connect

    McMillan, Charlie; Morgan, Nathanial; Goorley, Tom; Merrill, Frank; Funk, Dave; Korzekwa, Deniece; Laintz, Ken

    2012-01-26

    "Heritage of Science" is a short video that highlights the Stockpile Stewardship program at Los Alamos National Laboratory. Stockpile Stewardship was conceived in the early 1990s as a national science-based program that could assure the safety, security, and effectiveness of the U.S. nuclear deterrent without the need for full-scale underground nuclear testing. This video was produced by Los Alamos National Laboratory for screening at the Lab's Bradbury Science Museum in Los Alamos, NM and is narrated by science correspondent Miles O'Brien.

  4. Sobre la terapia génica para enfermedades de la retina.

    PubMed

    Fischer, M Dominik

    2017-07-11

    Las mutaciones en un gran número de genes provocan degeneración de la retina y ceguera sin que exista actualmente cura alguna. En las últimas décadas, la terapia génica para enfermedades de la retina ha evolucionado y se ha convertido en un nuevo y prometedor paradigma terapéutico para estas enfermedades poco comunes. Este artículo refleja las ideas y los conceptos que parten de la ciencia básica hacia la aplicabilidad de la terapia génica en el ámbito clínico. Se describen los avances y las reflexiones actuales sobre la eficacia de los ensayos clínicos en la actualidad y se discuten los posibles obstáculos y soluciones de cara al futuro de la terapia génica para enfermedades de la retina. © 2017 S. Karger AG, Basel.

  5. Los Angeles Basin

    NASA Image and Video Library

    2009-06-29

    The Los Angeles Basin is bordered on the north by the San Gabriel Mountains. Other smaller basins are separated by smaller mountain ranges, like the Verdugo Hills, and the Santa Monica Mountains in this image from NASA Terra spacecraft.

  6. Conceptos Basicos Sobre el Propano

    SciTech Connect

    2016-08-01

    El propano provee energia a mas de 143.000 vehiculos en los Estados Unidos y 23 millones en todo el mundo. Flotas de todos los Estados Unidos han implementado con exito el uso de vehiculos que funcionan con gas propano, y en la actualidad varios funcionan gracias a este gas, incluyendo autobuses escolares, lanzaderas y autobuses publicos, asi como tambien furgonetas, taxis, vehiculos utilizados por las fuerzas del orden, barredoras de calles y camiones para uso profesional. El propano tambien se utiliza con frecuencia en aplicaciones fuera de la carretera, tales como montacargas, podadoras y equipos de uso profesional y otros equipos agricolas. Las ventajas del propano incluyen la disponibilidad interna, su rendimiento y el hecho de que genera menos emisiones de gases contaminantes que otras alternativas energeticas.

  7. Los Alamos offers Fellowships

    NASA Astrophysics Data System (ADS)

    Los Alamos National Laboratory in New Mexico is calling for applications for postdoctoral appointments and research fellowships. The positions are available in geoscience as well as other scientific disciplines.The laboratory, which is operated by the University of California for the Department of Energy, awards J. Robert Oppenheimer Research Fellowships to scientists that either have or will soon complete doctoral degrees. The appointments are for two years, are renewable for a third year, and carry a stipend of $51,865 per year. Potential applicants should send a resume or employment application and a statement of research goals to Carol M. Rich, Div. 89, Human Resources Development Division, MS P290, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 by mid-November.

  8. Educación sobre sexualidad y prevención del VIH: un diagnóstico para América Latina y el Caribe

    PubMed Central

    DeMaria, Lisa M.; Galárraga, Omar; Campero, Lourdes; Walker, Dilys M.

    2016-01-01

    RESUMEN Objetivo Mostrar, a través de un diagnóstico en América Latina y el Caribe, el panorama legislativo y curricular sobre sexualidad y prevención contra el virus de inmunodeficiencia humana (VIH) en el ámbito escolar, contrastándolo con los comportamientos sexuales reportados en encuestas demográficas y de salud. Métodos En mayo de 2008 se realizó, con el apoyo del Fondo de Población de las Naciones Unidas (UNFPA), una encuesta a informantes clave en 34 países de la Región. El cuestionario autoaplicado solicitó información sustantiva de agentes de las diferentes partes interesadas, como ministerios de educación y de salud, sobre los programas de prevención contra el VIH/Sida que se están aplicando en las escuelas. Resultados Respondieron a la encuesta 27 países que representan 95,5% de la población objetivo (6 a 18 años de edad). La mayoría de los países informó tener al menos un libro de texto o un capítulo específico para enseñar los temas de educación sobre sexualidad y prevención del VIH. En la escuela secundaria se cubren la mayor parte de los temas pertinentes relevantes para la educación sobre sexualidad, pero no todos. Por ejemplo, el problema de la discriminación por orientación o preferencia sexual no se incluye en los programas escolares. Conclusiones El material educativo sobre sexualidad debe ser revisado y actualizado periódicamente de modo que refleje los avances en los temas y en la forma de tratar los contenidos. En cada país el currículo debe abordar el tema del respeto a la diversidad sobre orientación, preferencia e identidad sexuales, y en particular el manejo apropiado de la educación para prevenir infecciones de transmisión sexual (ITS) en hombres que tienen sexo con hombres. Los esfuerzos de evaluación de la efectividad de los programas deben contemplar desenlaces tales como marcadores biológicos (incidencia y prevalencia de ITS y embarazo) y no únicamente indicadores de conocimiento y

  9. Taxquake in Los Angeles

    ERIC Educational Resources Information Center

    Koltai, Leslie

    1978-01-01

    Outlines educational, personnel, legal, and political considerations facing the Los Angeles Community College District contingency planning committee in their efforts to develop plans to meet budgetary limitations foreseen in the passage of the Jarvis-Gann property tax limitation initiative. (TP)

  10. The Los Alamos primer

    SciTech Connect

    Serber, R.

    1992-01-01

    This book contains the 1943 lecture notes of Robert Serber. Serber was a protege of J. Robert Oppenheimer and member of the team that built the first atomic bomb - reveal what the Los Alamos scientists knew, and did not know, about the terrifying weapon they were building.

  11. Validacion de un Inventario Sobre La Percepcion de Los Padres de Superdotados Respecto a Los Servicios Educativos Disponibles Para Estos

    ERIC Educational Resources Information Center

    Medina Munoz, Arlette Zamarie

    2013-01-01

    In Puerto Rico, there isn't a survey that collects the parent's perception of the available services for gifted children. Considering this, in this investigation an instrument was created and scientifically validated to collect the parents' perception of the educational services available. The instrument was validated using internal and external…

  12. Validacion de un Inventario Sobre La Percepcion de Los Padres de Superdotados Respecto a Los Servicios Educativos Disponibles Para Estos

    ERIC Educational Resources Information Center

    Medina Munoz, Arlette Zamarie

    2013-01-01

    In Puerto Rico, there isn't a survey that collects the parent's perception of the available services for gifted children. Considering this, in this investigation an instrument was created and scientifically validated to collect the parents' perception of the educational services available. The instrument was validated using internal and external…

  13. Personal Safety for Children: A Guide for Parents = Una guia para los padres sobre la seguridad personal de los ninos.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC.

    Noting that parents and teachers have the responsibility of safeguarding children and teaching them the skills they need to be safe, this pamphlet, in Spanish and English versions, is designed to help parents talk to their children about how to protect themselves against abduction and exploitation. The pamphlet is organized into six sections.…

  14. Los Alamos Programming Models

    SciTech Connect

    Bergen, Benjamin Karl

    2016-07-07

    This is the PDF of a powerpoint presentation from a teleconference on Los Alamos programming models. It starts by listing their assumptions for the programming models and then details a hierarchical programming model at the System Level and Node Level. Then it details how to map this to their internal nomenclature. Finally, a list is given of what they are currently doing in this regard.

  15. Los Angeles, CA, USA

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This rare cloud and smog free view of Los Angeles, CA (34.0N, 118.5W) is a result of strong Santa Ana winds blowing from the east. Both cultural and natural features are well displayed and all of the major streets, highways and freeways can be traced in their entirety throughout the city as well as the major business and commercial sections. On the eastern edge of the scene, the San Andreas fault cuts across from southeast to northwest.

  16. Reflexión bioética sobre el uso de organismos genéticamente modificados

    PubMed Central

    Yunta, Eduardo Rodríguez

    2011-01-01

    El presente artículo reflexiona desde los 4 principios de la bioética el uso comercial de organismos genéticamente modificados. Se cuestiona fundamentalmente la falta de transferencia de tecnología entre el mundo desarrollado y en desarrollo y el que el presente sistema de patentamiento de organismos vivos modificados fomenta intereses comerciales y no da debida importancia al desarrollo sostenible de la agricultura y ganadería en los países en desarrollo, donde más se necesita. Se reflexiona sobre la importancia que tiene evaluar los riesgos antes de introducirse en el mercado organismos genéticamente modificados y la necesidad de regulación en los países. PMID:21927675

  17. Los Angeles, CA.

    NASA Image and Video Library

    1992-03-30

    STS003-010-593 (30 March 1982) --- A general view of the greater Los Angeles region of California (34,0N, 118.5W) showing the coastline, Vandenberg AFB, the south end of the Central Valley and the dry lake beds at Edwards AFB. A close look can pinpoint water on the lake beds at Edwards Air Force Base used previously for two shuttle landings. Among other features that can be seen are Oxnard, Santa Barbara, Bakersfield, Vandenberg Air Force Base, and The Ranch. Photo credit: NASA

  18. Conceptos Basicos Sobre el Gas Natural

    SciTech Connect

    2016-08-01

    El gas natural abastece cerca de 150.000 vehiculos en los Estados Unidos y aproximadamente 22 millones de vehiculos en todo el mundo. Los vehiculos de gas natural (NGV, por sus siglas en ingles) son una buena opcion para las flotas de vehiculos de alto kilometraje, tales como autobuses, taxis, vehiculos de recoleccion de basura, los cuales son alimentados centralmente u operan dentro de un area limitada o a lo largo de una ruta con estaciones de servicio de gas natural. Las ventajas del gas natural como combustible alternativo incluyen su disponibilidad interna, la red de distribucion establecida, un costo relativamente bajo, y los beneficios de las emisiones.

  19. Concepciones y concepciones alternativas de estudiantes universitarios/as de biologia y futuros maestros/as de Ciencia de escuela secundaria sobre la teoria de evolucion biologica por seleccion natural

    NASA Astrophysics Data System (ADS)

    Morales Ramos, Egda M.

    La teoria de evolucion biologica (TEB) por seleccion natural es uno de los conceptos unificadores mas importantes del curriculo de Biologia. En Puerto Rico se han hecho pocas investigaciones que abunden sobre las concepciones y concepciones alternativas (CA) que tienen los estudiantes universitarios/as de Biologia y los maestros/as de Ciencia del nivel secundario sobre esta teoria. La politica publica educativa actual establece mediante documentos normativos como los Estandares de contenido y Expectativas de grado del Programa de Ciencias [Puerto Rico Core Standards] la ensenanza de esta teoria. Sin embargo, no se encontraron preguntas sobre la seleccion natural en los ejercicios de practica provistos por el Departamento de Educacion para las pruebas estandarizadas lo cual puede influir para que no se ensene adecuadamente. Las preguntas de investigacion fueron 1. ¿Cuales son las concepciones y concepciones alternativas de estudiantes universitarios/as y de los futuros maestros y maestras de Ciencia sobre la TEB? 2. ¿Cuales conceptos que seleccionan los estudiantes universitarios/as y los futuros maestros y maestras de Ciencia sobre la TEB coinciden con lo aceptado como valido por la comunidad cientifica? y 3. ¿Como comparan las respuestas de la prueba original. v. Entendiendo el cambio biologico que mide concepciones y CA sobre la TEB por seleccion natural, con las de la traducida al idioma espanol? Se utilizo el metodo cuantitativo con un diseno de investigacion transversal por encuesta. La tecnica principal para recopilar los datos fue una prueba con doce items, que formo parte de un instrumento para el cual se recopilaron diversas fuentes de evidencia acerca de su validez. Las muestras estuvieron formadas por 69 estudiantes de Ciencias Naturales y por 16 estudiantes futuros maestros y maestras del nivel secundario de la UPR-RP. Se utilizaron estadisticas descriptivas, analisis de Ji cuadrado y se calcularon los coeficientes alfa de Cronbach y de Spearman

  20. Homework Tips for Parents = Consejos para los padres sobre la tarea escola.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC. Office of Intergovernmental and Interagency Affairs.

    Homework has been a part of students' lives since the beginning of formal school in the United States; the push for increased homework has increased, fueled by rising academic standards. Noting that parents involved can have either a positive or a negative influence on the value of homework, this booklet, in both English and Spanish, offers…

  1. Las Preguntas Que Hacen los Padres sobre la Escuela (Questions Parents Ask about School).

    ERIC Educational Resources Information Center

    National Opinion Research Center, Chicago, IL.

    This guide presents questions that parents frequently ask about their children's school along with answers to those questions. The questions and answers were prepared based on the results of studies conducted by the Partnership for Family Involvement in Education, the U.S. Department of Education, the GTE Foundation, and by the National Center for…

  2. Questions Parents Ask about Schools = Preguntas que hacen los padres sobre las escuelas. Revised.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC. Office of Intergovernmental and Interagency Affairs.

    Noting that parents play an important role in the school success of their elementary- and middle-school-aged children, this booklet offers research-based tips to provide both practical guidance and information about a range of education-related topics. Presented in a question-answer format in both English and Spanish versions, the booklet provides…

  3. Guia para los padres sobre educacion preescolar (A Parents' Guide to Early Childhood Education).

    ERIC Educational Resources Information Center

    Dodge, Diane Trister; Phinney, Joanna

    This handbook, entirely in Spanish, was originally intended for parents whose children attend programs which use "The Creative Curriculum for Early Childhood" (CCEC), but the information is also useful to parents whose children attend early childhood programs using other curriculum models based on child development theories. The purpose…

  4. Notas sobre los Sonidos Consonantes en Espanol (Notes on Consonant Sounds in Spanish)

    ERIC Educational Resources Information Center

    Ezquerra, Raimundo

    1974-01-01

    This paper examines the Spanish phonetic system, as set forth by Navarro Tomas in his "Manual de Pronunciacion Espanola," and discusses the influences exerted by certain sounds over others. (Text is in Spanish.) (CK)

  5. Questions Often Asked about Special Education Services = Preguntas sobre los servicios de educacion especial.

    ERIC Educational Resources Information Center

    Kupper, Lisa, Ed.

    This guide, available in both English and Spanish, answers questions often asked by parents about special education services. Questions and answers address the following topics: where to begin if a parent believes a child needs special education services, services available to very young children, the evaluation process, the Individualized…

  6. Guia para los padres sobre educacion preescolar (A Parents' Guide to Early Childhood Education).

    ERIC Educational Resources Information Center

    Dodge, Diane Trister; Phinney, Joanna

    This handbook, entirely in Spanish, was originally intended for parents whose children attend programs which use "The Creative Curriculum for Early Childhood" (CCEC), but the information is also useful to parents whose children attend early childhood programs using other curriculum models based on child development theories. The purpose…

  7. Discussions about the Nature of Science in a Course on the History of Astronomy. (Spanish Title: Discusiones sobre la Naturaleza de la Ciencia en un Curso sobre Historia de la Astronomía.) Discussões sobre a Natureza da Ciência em um Curso sobre a História da Astronomia

    NASA Astrophysics Data System (ADS)

    Pires de Andrade, Victória Flório; L'Astorina, Bruno

    2010-07-01

    There are an increasing number of researches in science education that affirm the importance of discussions on the "nature of science" in basic education level as well as in teacher training. The history of science applied to education is a way to contextualize epistemological discussions, allowing both the understanding of scientific content and learning about science concepts. We present some reasonably consensual definitions on the nature of science that have been widely discussed by the academic community. We show also some episodes in the history of astronomy which can lead to discussions involving some aspects of the nature of science, and how they can do it. Hay un número creciente de investigaciones en la enseñanza de las ciencias que afirman la importancia de debates sobre la "naturaleza de la ciencia" en la educación básica y formación del profesorado. La historia de la ciencia aplicada a la educación es una manera de contextualizar los debates de la epistemología, lo que permite tanto la comprensión de los contenidos científicos como el aprendizaje de conceptos científicos. En esto trabajo, presentamos algunas definiciones bastante consensuales sobre la naturaleza de la ciencia que han sido ampliamente discutidas por la comunidad académica y mostramos cómo algunos episodios en la historia de la astronomía pueden llevar a discusiones sobre algunos aspectos de la naturaleza de la ciencia. Há um número crescente de pesquisas na área de ensino de ciências que afirmam a importância de discussões sobre a "natureza da ciência" na educação básica e na formação de professores. A história da ciência aplicada ao ensino é uma maneira de contextualizar discussões epistemológicas, permitindo tanto a compreensão de conteúdos científicos quanto o aprendizado de noções sobre as ciências. Neste trabalho apresentamos algumas definições razoavelmente consensuais sobre a natureza da ciência que foram amplamente discutidas pela

  8. Los Alamos National Laboratory

    SciTech Connect

    Dogliani, Harold O

    2011-01-19

    The purpose of the briefing is to describe general laboratory technical capabilities to be used for various groups such as military cadets or university faculty/students and post docs to recruit into a variety of Los Alamos programs. Discussed are: (1) development and application of high leverage science to enable effeictive, predictable and reliability outcomes; (2) deter, detect, characterize, reverse and prevent the proliferation of weapons of mass destruction and their use by adversaries and terrorists; (3) modeling and simulation to define complex processes, predict outcomes, and develop effective prevention, response, and remediation strategies; (4) energetic materials and hydrodynamic testing to develop materials for precise delivery of focused energy; (5) materials cience focused on fundamental understanding of materials behaviors, their quantum-molecular properties, and their dynamic responses, and (6) bio-science to rapidly detect and characterize pathogens, to develop vaccines and prophylactic remedies, and to develop attribution forensics.

  9. Los biocombustibles y el futuro

    NASA Image and Video Library

    ¿Cómo podremos utilizar los biocombustibles en el futuro? La ingeniera aeroespacial de la NASA, Diana Centeno Gómez nos explica el futuro de los biocombustibles y cómo un día podrías trabajar con d...

  10. Protegiendo a su familia de los terremotos-Los siete pasos a la seguridad para prepararse en caso de un terremoto (en espa?ol y en ingles)

    USGS Publications Warehouse

    Desarrollado por American Red Cross, Asian Pacific Fund

    2007-01-01

    Les escribimos esta carta para comunicarle un mensaje sumamente importante sobre las preparaciones de emergencia. Historicamente, hemos sufrido terremotos aqui en el Area de la Bahia de San Francisco que han causado graves privaciones para los residentes de la comunidad y da?os increibles a nuestras ciudades. Es probable que suframos un terremoto de gran magnitud en los proximos 30 a?os. Muchos de nosotros venimos de otros paises donde hemos pasado por terremotos y por eso creemos entenderlos. Sin embargo, la manera que nos preparamos para terremotos en nuestros paises de origen puede ser distinta a la que empleamos aca en los Estados Unidos. Muy pocas personas mueren a causa de los derrumbes de los edificios en el Area de la Bahia porque la mayoria de los edificios son construidos para resistir el sacudimiento de la tierra. Pero es muy probable que su familia no tenga atencion medica, alimentos o que esten separados del uno al otro por dias o semanas. Finalmente depende de usted mantener a su familia a salvo hasta que llegue asistencia, por eso les pedimos que nos unamos para aprender a cuidar a su familia antes, durante, y despues de un terremoto. El primer paso es leer este libro. Cada uno de su familia, ni?os y adultos, pueden aprender como prepararse para un terremoto. Haga participar e incluya sus ni?os; pueden ayudarle a prepararse. Aproveche las clases ofrecidas en su comunidad sobre las preparaciones de terremotos por la Cruz Roja Estadounidense (American Red Cross). Estos cursos de preparacion son gratis y disponibles en espa?ol para todos en la comunidad sin tomar en cuenta la historia de la familia, estado legal, genero o edad. Les recomendamos que tome ventaja de estas clases gratuitas. Para mas informacion consulte la ultima pagina de este libro. Recuerde que un terremoto puede ocurrir sin aviso y la unica manera de reducir el da?o de terremotos es estar preparados. !Preparese!

  11. Los asuntos de la EPA

    EPA Pesticide Factsheets

    La labor de la agencia con la comunidad internacional se beneficiará de un enfoque en el cual las prácticas sostenibles sean de aquí en adelante parte de nuestro diálogo sobre asuntos de mutua preocupación.

  12. Taxonomía de asteroides y cometas basada en los espectros de Lyapunov

    NASA Astrophysics Data System (ADS)

    Tancredi, G.; Motta, V.; Froeschlé, C.

    Estudiaremos dos familias de objetos que sufren encuentros cercanos con planetas, a saber: la familia de cometas de Júpiter (JF) y los asteroides cercanos a la Tierra (NEAs). El movimiento de estos objetos es caótico en una escala de tiempo corta. Más aún, debido a los cambios erráticos en los elementos orbitales, la comparación de los valores actuales da poca información acerca de la posible vinculación dinámica entre los objetos de una misma familia. Calculamos una estimación finita de los Exponentes Característicos de Lyapunov (LCE), los llamamos Indicadores Característicos de Lyapunov (LCI) para ambas familias y analizamos las características del espacio de fase donde tiene lugar el movimiento de estos objetos. Integrando en un período suficientemente largo (e.g. 20000 años), encontramos que el LCI alcanza un valor cuasi-constante. La mayoría de los miembros de ambas familias muestran una concentración de los tiempos de Lyapunov (inverso del LCI) de alrededor de 50-100 años (Tancredi, 1995, Astron & Astrop., 299, 288). La concentración de los tiempos de Lyapunov es mayor para la familia de Júpiter que para los NEAs. Entre estos últimos, la menor dispersión se da para aquellos que cruzan la órbita de la Tierra. Se demostró que el espectro de los `indicadores locales' (Froeschlé et. al., 1990, Cel. Mec. 56, 307) o ``números de estiramiento'' (Voglis and Contopoulos, 1994, J. Phys. A 26, 4899) (relacionados con el LCI) son invariantes y nos dan una información más completa sobre el comportamiento caótico. Mediante la comparación de espectros discutimos la similitud entre los objetos de una misma familia y analizamos las diferentes posibles rutas al caos. Los espectros se clasifican mediante la comparación de los momentos de las distribuciones de los `números de estiramiento'. Aplicamos un método de agrupamiento jerárquico (Zappala et. al., 1990, Astron. J. 100, 2030) para identificar ``familias'' de espectros (grupos de espectros

  13. University Students' Conceptions about the Moon Phases. (Spanish Title: Concepciones de Estudiantes Universitários sobre Las Fases de la Luna.) Concepções de Estudantes Universitários sobre as Fases da Lua

    NASA Astrophysics Data System (ADS)

    de Fátima Oliveira Saraiva, Maria; da Silveira, Fernando Lang; Steffani, Maria Helena

    2011-07-01

    In this article we describe the development of a multiple choice test about lunar phases and analyze the results of its application to ten groups of Physics students at the UFRGS. During the improvement of the test, we noticed that the percentage of right answers about some concepts increased significantly when associated with the reformulation of the question, emphasizing the importance of being careful to avoid incorrect answers generated by unclear questions, and not by ignorance on the matter. We confirm the results of other studies that show that students have great difficulty to relate the Moon's phase with its position in the sky at given time. On the other hand, our results suggest that, in general, students of Physics understand the phenomenon of lunar phases better than the average of university students. En estese artículo se describe la elaboración de una prueba de opción múltiple sobre las fases de la Luna y se analizan los resultados de su aplicación en diez grupos de estudiantes de Física de UFRGS. Durante el mejoramiento de la prueba observamos que el porcentaje de aciertos creció considerablemente cuando considerada una nueva redacción de la pregunta, destacando el cuidado que se debe tomar a fin de evitar respuestas incorrectas generadas por preguntas poco claras y no a causa de la ignorancia de los estudiantes sobre el tema. Confirmamos los resultados de otros estudios que las mayores dificultades de los alumnos sobre el tema fases de la Luna están en relacionar la fase de la Luna con su posición en el cielo en determinado momento. Por otra parte, nuestros resultados sugieren que, en general, los estudiantes de la Física comprenden mejor el fenómeno de las fases lunares que el promedio de los estudiantes universitarios. Neste artigo descrevemos a elaboração de um teste de múltipla escolha sobre as fases da Lua e analisamos os resultados de sua aplicação em dez grupos de estudantes de Física da UFRGS. Durante o aprimoramento do

  14. Geomorphological Hazards in Los Angeles

    NASA Astrophysics Data System (ADS)

    Hadley, Richard F.

    This is a topical book that deals with the geomorphological and geological engineering problems associated with hillslope processes and sediment transport in the Los Angeles metropolitan area. There are few large cities in the United States where the problems of urban growth include such a distinctive physical environment, as well as the potential hazards of brush fires, earthquakes, and floods that occur in Los Angeles. The research and data used in the book are restricted to Los Angeles County and cover the period 1914-1978. The author has done a commendable job of synthesizing a large mass of data from diverse sources, including federal, state, and local agency reports, plus data from private groups such as professional technical societies and consultants.

  15. Los manuales de quimica en Espana (1788--1845): Protagonistas, terminologia, clasificaciones y orden pedagogico

    NASA Astrophysics Data System (ADS)

    Munoz Bello, Maria Rosa

    La presente tesis doctoral es una investigacion sobre los manuales de quimica utilizados en Espana de 1788 a 1845. Este trabajo proporciona una perspectiva general de un tema relevante en las ultimas decadas en Historia de la Ciencia, el estudio de los libros de texto. De acuerdo con las ultimas investigaciones realizadas en este terreno, el acto pedagogico es considerado como un proceso creativo, como espacio de encuentro de actores e intereses muy diversos, matizando las ideas defendidas por Thomas S. Kuhn. Recordemos que segun Kuhn, los libros de texto ofrecen una vision consensuada y normalizada del estado de la ciencia de su epoca, por lo que sus autores eliminan deliberadamente toda controversia y presentan asi una imagen distorsionada de la actividad cientifica. En cambio, se ha mostrado, por ejemplo, que en la ensenanza participan no solamente profesores y alumnos sino tambien otros muchos actores y todos ellos no unicamente con intereses puramente pedagogicos sino tambien con diversos intereses politicos y economicos que pueden conocerse a traves del estudio de los manuales. En esta tesis se pretende analizar los manuales de quimica en Espana desde 1788 hasta 1845. Para poder llevar a cabo la investigacion ha sido necesario precisar el objeto de estudio (libro de texto de quimica) durante el periodo estudiado (1788-1845) ya que no es adecuado adoptar la imagen actual de una disciplina que sufrio sustanciales cambios durante la epoca estudiada. Esta investigacion se centra en un momento especialmente importante para la quimica y que algunos historiadores han llegado a considerar "revolucionario". Durante estos anos se produjo un cambio importante en las teorias quimicas sobre la combustion y el concepto de elemento, asi como una reforma terminologica que originaron la aparicion de importantes controversias. Ademas, debido a la relacion de la quimica con otras disciplinas como la historia natural o la fisica ha sido necesario restringir el objeto de estudio

  16. Actitudes Éticas de los estudiantes y egresados en carrera de medicina con metodologías activas

    PubMed Central

    Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Stepke, Fernando Lolas; Silveira, Carla Cristina Costa; Komatsu, Ricardo Shoiti; Trindade, Eliane Mendonça Vilar; Guiotti, Murilo Galvão

    2010-01-01

    El presente estudio tiene por objeto desarrollar un diagnostico de la inserción integrada de la ética en la carrera de medicina brasileña con una metodología de aprendizaje basada en problemas y describir las percepciones de actitudes éticas de los estudiantes y egresados. El diseño metodológico es un estudio de caso, descriptivo y documental, con abordaje cualitativo y cuantitativo. La muestra de esta investigación ha sido constituida por 120 estudiantes y 40 egresados de dos promociones del Curso de Medicina de la ESCS. Este proyecto fue aprobado por el Comité de Ética en Investigación - SES/DF. Los estudiantes y egresados de la ESCS demostraron un buen manejo en el abordaje de los conflictos éticos y respeto a los pacientes. Sin embargo, el análisis de sensibilidad ética mostró una fragilidad en las percepciones y aptitudes inapropiadas de los estudiantes de la carrera de medicina, identificada básicamente en los años iniciales, que necesitan más discusiones sistematizadas sobre los aspectos éticos y bioéticos integrados a las actividades prácticas para estimular y fortalecer la reflexión ética de los estudiantes. PMID:20981242

  17. Mayo de Los Capomos, Sinaloa (Mayo of Los Capomos, Sinaloa).

    ERIC Educational Resources Information Center

    Freeze, Ray A.

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Mayo, an indigenous language of Mexico spoken in Los Capomos, in the state of Sinaloa. The objective of collecting such a representative sampling of the…

  18. Asymmetric Collapse of LOS Pipe.

    DTIC Science & Technology

    1980-05-26

    models that were used to simulate a LOS pipe . Still, the jet was eliminated in a Pinex model with a helical ribbon of polyolefin on the inside surface of...Target from the Pinex Model 71 with Poly Spiral in Experiment LS-3 .41 b l [ SECTION 1 *. INTRODUCTION 1.1 BACKGROUND Line-of-sight (LOS) pipes are...distance. 3.5.7 Simulation of Pinex Pipe . As shown in the photo- graphs provided in Figures 37 and 38, the Pinex-Standard Model and Pinex-Polyolefin Spiral

  19. Los Medanos College Fact Book.

    ERIC Educational Resources Information Center

    MacDonald, Ross; And Others

    Prepared to support the self-study and strategic planning processes at Los Medanos College (LMC), in Pittsburgh, California, this fact book offers information about LMC's students, staff, programs, services, facilities, and expenditures. The first section focuses on the student population, including a trend analysis and longitudinal data on…

  20. Palace Revolt in Los Angeles?

    ERIC Educational Resources Information Center

    Fuller, Bruce

    2010-01-01

    Antonio Villaraigosa, the mayor of Los Angeles, comes alive when recalling his start in local politics--as a labor organizer agitating for reform inside decrepit and overcrowded schools. In his quest to turn around the schools, the mayor has united working-class Latino parents, civil rights leaders, and big-money Democrats to challenge union…

  1. Palace Revolt in Los Angeles?

    ERIC Educational Resources Information Center

    Fuller, Bruce

    2010-01-01

    Antonio Villaraigosa, the mayor of Los Angeles, comes alive when recalling his start in local politics--as a labor organizer agitating for reform inside decrepit and overcrowded schools. In his quest to turn around the schools, the mayor has united working-class Latino parents, civil rights leaders, and big-money Democrats to challenge union…

  2. Neurobiología de la impulsividad y los trastornos de la conducta alimentaria*

    PubMed Central

    Orozco-Cabal, Luis Felipe; Herin, David

    2009-01-01

    Resumen Introducción La impulsividad es un rasgo de personalidad multidimensional relacionado con el control del comportamiento y las emociones. Está presente de manera diversa en los trastornos de la conducta alimentaria, particularmente, en la bulimia nerviosa (BN). Aunque la relación entre la impulsividad y BN ha sido objeto de numerosas investigaciones, en la actualidad se desconocen los sustratos neurobiológicos de esta relación. Objetivos Discutir críticamente la evidencia que sugiere que las alteraciones en los sistemas neuronales relacio-nados con las funciones ejecutivas, con la formación de preferencias y con la regulación de los estados emocionales sirven como base para el rasgo de personalidad impulsiva, así como su estado en subgrupos de pacientes con BN. Métodos Búsqueda selectiva de la literatura relevante. Resultados y conclusiones Esta discusión ilustra la complejidad de la relación entre la impulsividad y BN, donde la impulsividad actúa como un factor de vulnerabilidad que puede sensibilizar al sujeto con BN a estados emocionales negativos, durante los cuales modifica el impacto de estímulos internos y externos sobre el comportamiento y su regulación, favoreciendo así patrones de comportamiento maladaptativos e inflexibles. PMID:19838321

  3. Satellites monitor Los Alamos fires

    NASA Astrophysics Data System (ADS)

    Kalluri, Satya; White, Benjamin

    A man-made fire that was intended to be a “controlled burn” for clearing brush and wilderness at the Bandelier National Monument, New Mexico, became an inferno that devastated significant portions of Los Alamos during the first week of May 2000. Now known as the Cerro Grande fire, it was not confined to Los Alamos alone. The fire spread to 15% of the Santa Clara Indian Reservation and a substantial area of the surrounding national parks and U.S. forests.The National Weather Service estimates that more than 100,000 fires occur in the natural environment each year within the United States alone, of which about 90% are manmade. Remote sensing images from satellites could be used to detect and monitor these active fires and biomass burning. Forest fires have a significant environmental and economic impact, and timely information about their location and magnitude is essential to contain them.

  4. Los Angeles and Its Mistress Machine

    ERIC Educational Resources Information Center

    Marx, Wesley

    1973-01-01

    Los Angeles city has acute air pollution problems because of lack of an adequate mass transit system and the type of local industries. Air pollution in Los Angeles has affected agricultural production, vegetation, and public health in nearby areas. (PS)

  5. Los Angeles and Its Mistress Machine

    ERIC Educational Resources Information Center

    Marx, Wesley

    1973-01-01

    Los Angeles city has acute air pollution problems because of lack of an adequate mass transit system and the type of local industries. Air pollution in Los Angeles has affected agricultural production, vegetation, and public health in nearby areas. (PS)

  6. La prevención y los exámenes de detección de cáncer colorrectal

    Cancer.gov

    Vea el Facebook Live del NCI en español sobre la prevención y los exámenes de detección de cáncer colorrectal. La Sra. Sandra San Miguel del NCI y el Dr. Elmer Huerta del Washington Cancer Institute, MedStar Washington Hospital Center hablan sobre la importancia de la educación y las estrategias de prevención para aumentar el número de exámenes de detección de cáncer colorrectal.

  7. Los Alamos Science: Number 16

    SciTech Connect

    Cooper, N.G.

    1988-01-01

    It was an unusually stimulating day and a half at Los Alamos when two Nobel Laureates in physiology, a leading paleontologist, and a leading bio-astrophysicist came together to discuss ''Unsolved Problems in the Science of Life,'' the topic of the second in a series of special meetings sponsored by the Fellows of the Laboratory. Just like the first one on ''Creativity in Science,'' this colloquium took us into a broader arena of ideas and viewpoints than is our usual daily fare. To contemplate the evolution and mysteries of intelligent life from the speakers' diverse points of view at one time, in one place was indeed a rare experience.

  8. Dinámica y crecimiento de los granos de polvo en la nebulosa protoplanetaria

    NASA Astrophysics Data System (ADS)

    de La Fuente Marcos, Carlos

    2001-06-01

    En el escenario estándar de la formación planetaria, los planetesimales (cuerpos de tamaño kilométrico) crecen a partir de granos de polvo, similares a los interestelares, embebidos en un disco gaseoso denominado nebulosa protoplanetaria. Durante esta etapa, los movimientos del gas pueden tener gran influencia en la dinámica y el crecimiento de los granos de polvo, dado que el flujo kepleriano del gas frena el movimiento de los mismos haciendo que caigan hacia el Sol, y la turbulencia inhibe la inestabilidad gravitacional de la capa de polvo. Aunque se acepta que los planetesimales fueron los elementos constituyentes de los planetas, todavía se desconoce cómo se produjo la formación de los mismos. Por esta razón, en los estudios más recientes, existe un renovado interés por comprender mejor la evolución de la capa de polvo inmersa en el disco gaseoso de la Nebulosa. El gas que fluye en el disco puede engendrar estructuras carentes de simetría axial, como por ejemplo ondas espirales y vórtices, a partir de gran variedad de mecanismos de excitación e inestabilidad. En 1995, Barge y Sommeria pusieron de manifiesto que la existencia de vórtices gaseosos persistentes en la nebulosa solar tendría importantes consecuencias sobre la formación de los planetesimales y el posterior crecimiento de los planetas gigantes. La investigación desarrollada en esta Tesis analiza la relación entre el polvo y el gas debida al acoplamiento por fricción dinámica entre ambos; en concreto, se estudia el efecto del flujo medio del gas sobre la dinámica de las partículas de polvo. El primer objetivo es investigar en profundidad los procesos de captura y crecimiento de los granos de polvo dentro de un vórtice y su posible relevancia en cuanto a la formación de los planetesimales. El segundo objetivo es la exploración de los efectos de ondas espirales propagándose en el disco gaseoso sobre la dinámica y el crecimiento de las partículas. La presencia de líneas de

  9. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIRST FLOOR DOORS TO THE CITY CLERK AND TAX & PERMIT DIVISION OFFICES, FACING NORTH. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  10. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINTH FLOOR NORTH CORRIDOR STAIR NUMBER NINE DOOR HARDWARE, FACING WEST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  11. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL FOURTEENTH FLOOR SOUTH OFFICE WING SHOWING TYPICAL DOOR HARDWARE, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  12. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR BREAK ROOM OFF OF ORIGINAL ART COMMISSION ROOMS, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  13. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR BREAK ROOM OFF OF ORIGINAL ART COMMISSION ROOMS, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  14. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR Y-CORRIDOR NORTH SIDE OF ELEVATOR LOBBY, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  15. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR Y-CORRIDOR SOUTH SIDE OF ELEVATOR LOBBY, FACING NORTHEAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  16. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR Y-CORRIDOR, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  17. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR Y-CORRIDOR NEAR ROOM 1403, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  18. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR Y-CORRIDOR, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  19. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR Y-CORRIDOR SOUTH SIDE OF ELEVATOR LOBBY, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  20. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TENTH FLOOR SOUTH WING CAFETERIA FOOD LINE, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  1. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL TWENTY-SEVENTH FLOOR WEST EXTERIOR GALLERY SOUTHEAST STAIR TO PYRAMID, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  2. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINTH FLOOR NORTH OFFICE WING SHOWING PARTITIONS, WINDOWS AND RADIATOR, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  3. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING RADIATOR AND WINDOWS, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  4. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL TENTH FLOOR NORTH OFFICE WING SHOWING RADIATOR AND WINDOW, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  5. John Ash, ALA., Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, ALA., Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINTH FLOOR NORTH OFFICE WING SHOWING PARTITIONS, WINDOWS AND RADIATOR, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  6. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ENTRANCE COURTYARD SHOWING BRONZE DOORS, LIGHT FIXTURES AND GRILLS, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  7. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ENTRANCE COURTYARD SHOWING BRONZE DOORS AND HANDRAILS, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  8. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ENTRANCE COURTYARD SHOWING FLOORING, COLUMNS AND BRONZE DOORS, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  9. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NORTH ENTRANCE SHOWING DOORS AND LIGHT FIXTURES, FACING SOUTH. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  10. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NORTH ENTRANCE SHOWING STAIRS, DOORS AND WINDOW CONFIGURATION, FACING SOUTH. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  11. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL ELEVENTH FLOOR WATER TANKS TO THE EAST OF THE ELEVATOR LOBBY, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  12. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL ELEVENTH FLOOR ELEVATOR LOBBY, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  13. Bruce D. Judd; FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd; FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL EIGHTH FLOOR SOUTHWEST CORNER OFFICE ROOM 800, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  14. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL EAST ELEVATION NORTH GARAGE DOOR, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  15. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL EIGHTH FLOOR EAST PARTITIONS IN SOUTH OFFICE WING, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  16. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TWELFTH FLOOR ELEVATOR LOBBY, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  17. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL EIGHTH FLOOR SOUTH OFFICE WING, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  18. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TWELFTH FLOOR NORTHWEST STAIRWELL, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  19. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TWENTY-SECOND FLOOR ELEVATOR LOBBY, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  20. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL EAST ELEVATION SHOWING BRIDGE AND ARCHED ENTRANCES, FACING WEST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  1. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SIXTH FLOOR SHOWING ENCLOSED ROTUNDA DOME STRUCTURE AT NORTHWEST ACCESS DOOR, FACING SOUTHEAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  2. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TWENTIETH FLOOR JUDGE'S TOILET ROOM, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  3. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL EIGHTH FLOOR SOUTHEAST CORNER OFFICE ROOM 800, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  4. Bruce D. Judd; FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd; FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL TWELFTH FLOOR DOORS TO ROOM 1200, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  5. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL EIGHTH FLOOR WEST OFFICE WING DOORS TO ROOM 848, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  6. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ELEVATION SHOWING ARCADE, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  7. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL EAST ELEVATION LOADING DOCK ENTRANCE, FACING WEST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  8. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL EIGHTH FLOOR NORTH OFFICE WING SHOWING PARTITIONS, FACING NORTH. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  9. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TWELFTH FLOOR ELEVATOR LOBBY, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  10. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL EAST ELEVATION PEDESTRIAN ENTRY, FACING WEST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  11. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SIXTH FLOOR ZONING ADMINISTRATORS OFFICE SHOWING WOOD AND GLASS PARTITIONS, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  12. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL ELEVENTH FLOOR, NORTHWEST STAIR FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  13. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL EIGHTH FLOOR SOUTH OFFICE WING, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  14. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SIXTH FLOOR NORTH OFFICE AREA, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  15. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR NORTH OFFICE AREA, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  16. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING DEMOLITION OF SOUTH WALL, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  17. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING BEAM AND COLUMN CONNECTION NEAR NORTHWEST CORNER, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  18. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING DEMOLITION OF WEST WALL, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  19. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING BEAM AND COLUMN CONNECTION NEAR SOUTHEAST CORNER, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  20. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING STRUCTURAL PIERS AND FLORESCENT LIGHTS, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  1. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL ELEVENTH FLOOR KITCHEN OF EXECUTIVE DINING AREA SHOWING ARCHED STRUCTURE, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  2. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  3. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR WEST OFFICE AREA THAT WAS ORIGINAL ART COMMISSION ROOMS, FACING NORTHWEST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  4. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR NORTH OFFICE AREA, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  5. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  6. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR WEST OFFICE AREA THAT WAS ORIGINAL ART COMMISSION ROOMS, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  7. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR, SERVICE AREA DOOR NEAR ELEVATOR LOBBY, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  8. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL SIXTH FLOOR NORTH OFFICE AREA WINDOW, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  9. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING WOOD AND GLASS PARTITIONS, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  10. Tips for Parents on Keeping Children Drug Free = Consejos para Los Padres Sobre Como Mantener a Los Hijos Libres de La Droga.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC. Office of Intergovernmental and Interagency Affairs.

    Research shows that recent trends in youth drug use have stabilized; however, the rates of use remain at high levels. It has been shown that the earlier drug use is initiated, the more likely a person is to develop drug problems later in life. Youth substance abuse may lead to many other problems that affect not only the child, but also the…

  11. A Parent's Guide to Infant/Toddler Programs = Guia para los padres sobre los programas de cuidado infantil de 0-3 anos.

    ERIC Educational Resources Information Center

    Dodge, Diane Trister; Dombro, Amy Laura; Colker, Laura J.

    Information on how warm and responsive care can help shape infants' and toddlers' development and their ability to learn can be reassuring for concerned parents. This guide, in English and Spanish versions, presents quality child care as a partnership between the child caregiver and the parents with the primary goal of benefiting the child. The…

  12. Parenting Information for Parents: Books 1-3 (Informacion Para Los Padres Sobre La Crianza De Los Hijos: Libros 1-3).

    ERIC Educational Resources Information Center

    Moreno, Steve

    These 3 booklets provide ideas, guidelines, and activities for establishing effective parenting and are part of a series of 22 booklets specifically designed to help parents understand their children and help them to learn. The first booklet (booklet #20) discusses preparation for parenthood, infant and toddler developmental stages, the importance…

  13. "Que vienen los lobos!" (Breve nota sobre el plural de los apellidos) ("May The Wolves Come:" [A Brief Note on the Plural of Surnames])

    ERIC Educational Resources Information Center

    Vivaldi, Gonzalo Martin

    1975-01-01

    This article discusses the problems that arise with the formation of plural forms of surnames in Spanish, problems both with morphology and with ambiguity. Suggestions as to how to lessen problems are made. (Text is in Spanish.) (CLK)

  14. Lo Que los Padres y los Maestros Deberian Saber sobre la...Aceleraction (What Parents and Teachers Should Know about Academic Acceleration).

    ERIC Educational Resources Information Center

    Guenther, Alex

    Designed for Spanish-speaking educators and parents, this pamphlet discusses academic acceleration for gifted children. Major types of academic acceleration and their benefits are described. These include: (1) early admission to kindergarten that saves parents of gifted children the expenses of a year of preschool, allows children to be…

  15. Parenting Information for Parents: Books 1-3 (Informacion Para Los Padres Sobre La Crianza De Los Hijos: Libros 1-3).

    ERIC Educational Resources Information Center

    Moreno, Steve

    These 3 booklets provide ideas, guidelines, and activities for establishing effective parenting and are part of a series of 22 booklets specifically designed to help parents understand their children and help them to learn. The first booklet (booklet #20) discusses preparation for parenthood, infant and toddler developmental stages, the importance…

  16. Declaración SPIRIT 2013: definición de los elementos estándares del protocolo de un ensayo clínico*

    PubMed Central

    Chan, An-Wen; Tetzlaff, Jennifer M.; Altman, Douglas G.; Laupacis, Andreas; Gøtzsche, Peter C.; Krleža-Jerić, Karmela; Hrobjartsson, Asbjørn; Mann, Howard; Dickersin, Kay; Berlin, Jesse A.; Dore, Caroline J.; Parulekar, Wendy R.; Summerskill, William S.M.; Groves, Trish; Schulz, Kenneth F.; Sox, Harold C.; Rockhold, Frank W.; Rennie, Drummond; Moher, David

    2016-01-01

    Resumen El protocolo de un ensayo clínico es la base para planificar, ejecutar, publicar y evaluar el ensayo. Sin embargo, los protocolos y las guías que existen para su elaboración varían enormemente en cuanto a su calidad y contenido. En este artículo se describe la elaboración sistemática y el alcance de la Declaración SPIRIT 2013 (denominada así por la sigla en inglés de Standard Protocol items: Recommendations for Interventional Trials o Elementos estándares de un protocolo: recomendaciones para los ensayos de intervención), una guía en la que se establecen los contenidos mínimos que debe tener el protocolo de un ensayo clínico. La lista de comprobación de la declaración SPIRIT, que consta de 33 elementos, se aplica a los protocolos de todos los ensayos clínicos y se centra más en el contenido que en el formato. En esta lista se recomienda hacer una descripción completa de lo que se ha planificado, aunque no se establece cómo diseñar o ejecutar un ensayo. Al brindar orientación sobre los contenidos fundamentales, las recomendaciones SPIRIT procuran facilitar la redacción de protocolos de alta calidad. El cumplimiento de las recomendaciones SPIRIT debería mejorar la transparencia y la exhaustividad de los protocolos de los ensayos en beneficio de los investigadores, los participantes, los pacientes, los patrocinadores, los financiadores, los comités de ética de la investigación o las juntas de revisión institucionales, los revisores, las revistas biomédicas, los registros de ensayos, los formuladores de políticas, los organismos reguladores y otras partes interesadas clave. PMID:27440100

  17. Los Alamos PC estimating system

    SciTech Connect

    Stutz, R.A.; Lemon, G.D.

    1987-01-01

    The Los Alamos Cost Estimating System (QUEST) is being converted to run on IBM personal computers. This very extensive estimating system is capable of supporting cost estimators from many different and varied fields. QUEST does not dictate any fixed method for estimating. QUEST supports many styles and levels of detail estimating. QUEST can be used with or without data bases. This system allows the estimator to provide reports based on levels of detail defined by combining work breakdown structures. QUEST provides a set of tools for doing any type of estimate without forcing the estimator to use any given method. The level of detail in the estimate can be mixed based on the amount of information known about different parts of the project. The system can support many different data bases simultaneously. Estimators can modify any cost in any data base.

  18. Polvo en la Región de los Troyanos

    NASA Astrophysics Data System (ADS)

    Gilhutton, R.; Brunini, A.; Coldwell, G.

    La posible existencia de un anillo de polvo en la resonancia 1:1 con Júpiter formado por partículas provenientes de colisiones de asteroides fue propuesta por Liou and Zook (Icarus 113, 403, 1995) y estudiada extensamente por Vieira Martins and Gomes (VIII Reunión Regional Latinoamericana de Astronomía, Montevideo,1995). Si bien las partículas quedarían atrapadas sólo por períodos de algunos miles de años, el proceso colisional continuo en el cinturón de asteroides mantendría constante la densidad, presentándose una mayor concentración en la región de los troyanos. En el presente trabajo se presentan resultados preliminares sobre observaciones polarimétricas realizadas desde CASLEO de la región de L5 que confirmarían la existencia y variaciones de densidad en el anillo de polvo.

  19. Una Guia de Consejos Practicos Sobre la Lectura para los Padres (A Guide to Reading Tips for Parents).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    The No Child Left Behind program changes the federal role in education by asking America's schools to describe their success in terms of what each student accomplishes. The information in this reading guide, presented in Spanish, was developed by the United States Department of Education to assist parents, caregivers, and teachers in understanding…

  20. The ABCs of Special Education: A Handbook for Parents = El ABS Sobre Educacion Especial: Un Folleto para los Padres.

    ERIC Educational Resources Information Center

    Ewing, Preston E., Jr.; Hinton, Valeska S.

    This bilingual handbook is intended to help parents understand their rights under P.L. 94-142, the Education for All Handicapped Children Act. The following topics are addressed: the Act's legislative history, identification of special education, explanation of P.L. 94-142, parents' rights to know, student records, student testing, students'…

  1. A Guide for Parents about Retention and Promotion = Una Guia para los Padres de Familia sobre Retencion y Promocion.

    ERIC Educational Resources Information Center

    State Univ. of New York, Oneonta. Coll. at Oneonta. Eastern Stream Center on Resources and Training.

    This bilingual (English and Spanish) brochure explains why retention is common among migrant students and what parents can do to help their children succeed in school. By second grade, nearly 50 percent of migrant students in the nation are older than their classmates and only about 50 percent of migrant students graduate from high school.…

  2. El Conocimiento Ocupacional y del Yo para los Grupos Especiales. Monografias sobre el Conocimiento Ocupacional y del Yo.

    ERIC Educational Resources Information Center

    Hoyt, Kenneth B.

    This Spanish translation of ED 132 428 includes the three papers representing Office of Education attempts to face the need for improving delivery of career education to special portions of the population. New additions are brief sections on basic definitions and additional considerations of the significance of work. The first paper, on career…

  3. [Sobre la (No) Responsabilidad de la Tecnociencia en los Problemas Ambientales y la Búsqueda de Política].

    PubMed

    Martínez Barrera, Jorge

    2016-01-01

    In this paper I propose to reflect upon modern configuration of technique, i.e., technoscience, and our responsibility towards environmental management. I show that the technological products of our world imply a certain attitude of aggression towards nature, contrasting with the attitude of protection from her, which was peculiar of the pre-technological world. Finally I suggest recovering the classical notion of politics as a possible alternative for controlling techno-scientific imperatives.

  4. The ABCs of Special Education: A Handbook for Parents = El ABS Sobre Educacion Especial: Un Folleto para los Padres.

    ERIC Educational Resources Information Center

    Ewing, Preston E., Jr.; Hinton, Valeska S.

    This bilingual handbook is intended to help parents understand their rights under P.L. 94-142, the Education for All Handicapped Children Act. The following topics are addressed: the Act's legislative history, identification of special education, explanation of P.L. 94-142, parents' rights to know, student records, student testing, students'…

  5. Trouble Brewing in Los Angeles. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    The city of Los Angeles will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Los Angeles faces a total $152.6 billion liability for pensions that are underfunded--including $49.1 billion for the city pension systems, $2.4 billion for…

  6. The Politics of School Desegregation: Los Angeles.

    ERIC Educational Resources Information Center

    Hart-Nibbrig, Nand

    This paper chronicles important events surrounding the desegregation of Los Angeles public schools, focusing on underlying political factors and roles of various individuals and community groups in the desegregation process. The author's principal contention is that Los Angeles schools remain segregated because powerful individuals and groups have…

  7. Los Alamos Neutron Science Center

    SciTech Connect

    Kippen, Karen Elizabeth

    2016-11-08

    For more than 30 years the Los Alamos Neutron Science Center (LANSCE) has provided the scientific underpinnings in nuclear physics and material science needed to ensure the safety and surety of the nuclear stockpile into the future. In addition to national security research, the LANSCE User Facility has a vibrant research program in fundamental science, providing the scientific community with intense sources of neutrons and protons to perform experiments supporting civilian research and the production of medical and research isotopes. Five major experimental facilities operate simultaneously. These facilities contribute to the stockpile stewardship program, produce radionuclides for medical testing, and provide a venue for industrial users to irradiate and test electronics. In addition, they perform fundamental research in nuclear physics, nuclear astrophysics, materials science, and many other areas. The LANSCE User Program plays a key role in training the next generation of top scientists and in attracting the best graduate students, postdoctoral researchers, and early-career scientists. The U.S. Department of Energy (DOE), National Nuclear Security Administration (NNSA) —the principal sponsor of LANSCE—works with the Office of Science and the Office of Nuclear Energy, which have synergistic long-term needs for the linear accelerator and the neutron science that is the heart of LANSCE.

  8. Los Alamos Laser Eye Investigation.

    SciTech Connect

    Odom, C. R.

    2005-01-01

    A student working in a laser laboratory at Los Alamos National Laboratory sustained a serious retinal injury to her left eye when she attempted to view suspended particles in a partially evacuated target chamber. The principle investigator was using the white light from the flash lamp of a Class 4 Nd:YAG laser to illuminate the particles. Since the Q-switch was thought to be disabled at the time of the accident, the principal investigator assumed it would be safe to view the particles without wearing laser eye protection. The Laboratory Director appointed a team to investigate the accident and to report back to him the events and conditions leading up to the accident, equipment malfunctions, safety management causal factors, supervisory and management action/inaction, adequacy of institutional processes and procedures, emergency and notification response, effectiveness of corrective actions and lessons learned from previous similar events, and recommendations for human and institutional safety improvements. The team interviewed personnel, reviewed documents, and characterized systems and conditions in the laser laboratory during an intense six week investigation. The team determined that the direct and primary failures leading to this accident were, respectively, the principle investigator's unsafe work practices and the institution's inadequate monitoring of worker performance. This paper describes the details of the investigation, the human and institutional failures, and the recommendations for improving the laser safety program.

  9. 9. NORTHSIDE OF HYPERION BOULEVARD VIADUCT OVERCROSSING OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTHSIDE OF HYPERION BOULEVARD VIADUCT OVERCROSSING OF LOS ANGELES RIVER. LOOKING EAST/SOUTHEAST. HYPERION BOULEVARD OVERCROSSING OF LOS ANGELES RIVER IS UPPER SECTION OF VIADUCT. GLENDALE BOULEVARD IS LOWER SECTION OF RIVER OVERCROSSING. - Glendale-Hyperion Viaduct, Spanning Golden State Freeway (I-5) & Los Angeles River at Glendale Boulevard, Los Angeles, Los Angeles County, CA

  10. Gobierno Federal Contina Investigacin Cientfica Sobre Erupciones en Flint

    EPA Pesticide Factsheets

    Flint, MICH. (24 de marzo, 2016) - Los expertos federales, del estado y del condado de salud y agua entienden que los residentes de Flint están preocupados por la calidad general de su agua-tanto como para beber y para bañarse. En este momento, el an

  11. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    USGS Publications Warehouse

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C.; Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  12. 47. LINED SECTION OF AQUEDUCT LOOKING NORTHWEST, COTTONWOOD Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. LINED SECTION OF AQUEDUCT LOOKING NORTHWEST, COTTONWOOD - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  13. 82. FIRST AND SECOND AQUEDUCTS LOOKING NORTHEAST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    82. FIRST AND SECOND AQUEDUCTS LOOKING NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  14. 87. AQUEDUCT IN COVERED CONDUIT LOOKING NORTHWEST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    87. AQUEDUCT IN COVERED CONDUIT LOOKING NORTHWEST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  15. 84. LA AQUEDUCT CROSSING CALIFORNIA AQUEDUCT LOOKING NORTH Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    84. LA AQUEDUCT CROSSING CALIFORNIA AQUEDUCT LOOKING NORTH - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  16. 78. SECOND AQUEDUCT LOOKING SOUTH NEAR PINETREE SIPHON Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    78. SECOND AQUEDUCT LOOKING SOUTH NEAR PINETREE SIPHON - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  17. 2. LEE VINING INTAKE, MONO LAKE IN BACKGROUND. Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LEE VINING INTAKE, MONO LAKE IN BACKGROUND. - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  18. 40. PLEASANT VALLEY RESERVOIR DAM LOOKING NORTHWEST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. PLEASANT VALLEY RESERVOIR DAM LOOKING NORTHWEST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  19. Shuttle Endeavour Flyover of Los Angeles Landmarks

    NASA Image and Video Library

    Space shuttle Endeavour atop NASA's Shuttle Carrier Aircraft flew over many Los Angeles area landmarks on its final ferry flight Sept. 21, 2012, including the Coliseum, the Hollywood Sign, Griffith...

  20. Publications of Los Alamos research 1988

    SciTech Connect

    Varjabedian, K.; Dussart, S.A.; McClary, W.J.; Rich, J.A.

    1989-12-01

    This bibliography lists unclassified publications of work done at the Los Alamos National Laboratory for 1988. The entries, which are subdivided by broad subject categories, are cross-referenced with an author index and a numeric index.

  1. Environmental surveillance at Los Alamos during 1994

    SciTech Connect

    1996-07-01

    This report describes environmental monitoring activities at Los Alamos National Laboratory for 1994. Data were collected to assess external penetrating radiation, airborne emissions, liquid effluents, radioactivity of environmental materials and food stuffs, and environmental compliance.

  2. New Rad Lab for Los Alamos

    SciTech Connect

    2008-08-06

    The topping out ceremony for a key construction stage in the Los Alamos National Laboratory's newest facility, the Radiological Laboratory Utility & Office Building. This is part of the National Nu...  

  3. New Rad Lab for Los Alamos

    ScienceCinema

    None

    2016-07-12

    The topping out ceremony for a key construction stage in the Los Alamos National Laboratory's newest facility, the Radiological Laboratory Utility & Office Building. This is part of the National Nu...  

  4. Edward Teller Returns to LOS Alamos

    NASA Astrophysics Data System (ADS)

    Hecker, Siegfried S.

    2010-01-01

    I was asked to share some reflections of Edward Teller's return to Los Alamos during my directorship. I met Teller late in his life. My comments focus on that time and they will be mostly in the form of stories of my interactions and those of my colleagues with Teller. Although the focus of this symposium is on Teller's contributions to science, at Los Alamos it was never possible to separate Teller's science from policy and controversy ...

  5. View of Los Angeles, California area

    NASA Image and Video Library

    1975-07-16

    AST-14-881 (16 July 1975) --- An excellent view of Los Angeles, California, as photographed from the Apollo spacecraft in Earth orbit during the joint U.S.-USSR Apollo-Soyuz Test Project (ASTP) mission. Downtown Los Angeles is near the center of the picture. The photograph was taken at an altitude of 193 kilometers (120 statute miles), with a 70mm Hasselblad camera using SO-242 high-definition Ektachrome film.

  6. Internship at Los Alamos National Laboratory

    SciTech Connect

    Dunham, Ryan Q.

    2012-07-11

    Los Alamos National Laboratory (LANL) is located in Los Alamos, New Mexico. It provides support for our country's nuclear weapon stockpile as well as many other scientific research projects. I am an Undergraduate Student Intern in the Systems Design and Analysis group within the Nuclear Nonproliferation division of the Global Security directorate at LANL. I have been tasked with data analysis and modeling of particles in a fluidized bed system for the capture of carbon dioxide from power plant flue gas.

  7. La masa de los grandes impactores

    NASA Astrophysics Data System (ADS)

    Parisi, M. G.; Brunini, A.

    Los planetas han sido formados fundamentalmente acretando masa a través de colisiones con planetesimales sólidos. La masa más grande de la distribución de planetesimales y las masas máxima y mínima de los impactores, han sido calculadas usando los valores actuales del período y de la inclinación de los planetas (Lissauer & Safronov 1991; Parisi & Brunini 1996). Recientes investigaciones han mostrado, que las órbitas de los planetas gigantes no han sufrido variaciones con el tiempo, siendo su movimiento regular durante su evolución a partir de la finalización de la etapa de acreción (Laskar 1990, 1994). Por lo tanto, la eccentricidad actual de los planetas gigantes se puede utilizar para imponer una cota máxima a las masas y velocidades orbitales de los grandes impactores. Mediante un simple modelo dinámico, y considerando lo arriba mencionado, obtenemos la cota superior para la masa del planetesimal más grande que impactó a cada planeta gigante al final de su etapa de acreción. El resultado más importante de este trabajo es la estimación de la masa máxima permitida para impactar a Júpiter, la cúal es ~ 1.136 × 10 -1, siendo en el caso de Neptuno ~ 3.99 × 10 -2 (expresada en unidades de la masa final de cada planeta). Además, fue posible obtener la velocidad orbital máxima permitida para los impactores como una función de su masa, para cada planeta. Las cotas obtenidas para la masa y velocidad de los impactores de Saturno y Urano (en unidades de la masa y velocidad final de cada planeta respectivamente) son casi las mismas que las obtenidas para Júpiter debido a que estos tres planetas poseen similar eccentricidad actual. Nuestros resultados están en buen acuerdo con los obtenidos por Lissauer & Safronov (1991). Estas cotas podrían ser utilizadas para obtener la distribución de planetesimales en el Sistema Solar primitivo.

  8. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL THIRD FLOOR SESSION ROOM OF THE BOARD OF PUBLIC WORKS SHOWING BOARD ROOM TABLE AND CHAIRS, FACING SOUTH. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  9. Los Angeles Community Colleges Student Characteristics, Fall 1997.

    ERIC Educational Resources Information Center

    Tillberg, Rebecca; Crespo, Sarah P.; Lagrimas, Joseph

    This report documents Los Angeles Community Colleges' student characteristics. It begins with a glossary providing specific definitions for the student characteristic criteria. Descriptive summaries and tables of student characteristic data are provided for the Los Angeles Community College District, Los Angeles City College, East Los Angeles…

  10. The Effects of Los Angeles Universal Preschool on Quality Preschool Teacher Retention in Los Angeles County

    ERIC Educational Resources Information Center

    Lopez Stevens, Holly Anne

    2010-01-01

    The purpose of this study was to determine if the implementation of Los Angeles Universal Preschool (LAUP) programs has a positive effect on the retention of quality preschool teachers in Los Angeles County. In prior work, preschool teacher retention is associated with wages, program structure, program process, professional development, and…

  11. Investigaccion-accion en la sala de clases sobre las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios y su relacion reciproca con el aprendizaje de las ciencias biologicas

    NASA Astrophysics Data System (ADS)

    Cordova-Santiago, Lizzette Astrid

    La investigacion---accion que se llevo a cabo en la sala de clases tenia como punto de partida las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios para luego examinar sus implicaciones en el proceso de aprendizaje de las Ciencias Biologicas. ¿Que se supone que hagan las creencias en relacion con el aprendizaje? ¿En que consiste incorporar este aspecto a la practica educativa universitaria? Utilizando el modelo de Kemmis y McTaggart (1987) la investigacion-accion se planteo como un proceso dinamico en cuatro momentos en espiral constituidos por la planificacion, la accion, la observacion y la reflexion. Cada una de las fases tuvo una intencion retrospectiva y prospectiva formando una espiral de autorreflexion del conocimiento y la accion. Se llevaron a cabo audio grabaciones en clases y analisis de documentos. Ademas, la profesora-investigadora hizo un portafolio para reflexionar sobre las creencias de la cultura de la ciencia que tienen los estudiantes y las creencias del aprendizaje que tiene la profesora y sobre como la comprension de estos elementos ayudo a mejorar su practica educativa a traves del tiempo. Los resultados obtenidos apuntan a que las creencias de la cultura de la ciencia que tiene el grupo de estudiantes son diversas. Ellos si creen que la ciencia tiene una cultura la cual describieron como: complicada y desconocida que evoluciona constantemente, que es un conjunto de metodos, que es altamente tecnologica, que resuelve problemas de salud, ayuda a interpretar la realidad del mundo que los rodea y su origen y que existen unas intersecciones entre la ciencia y el poder. Sobre las creencias del proceso de aprendizaje de la profesora-investigadora, estas senalan que el modelaje de actores, la vision de la academia que tiene ella asi como la participacion y negociacion entre todos los involucrados en el proceso educativo, son factores que inciden en el proceso de aprendizaje.

  12. Publications of Los Alamos Research, 1983

    SciTech Connect

    Sheridan, C.J.; McClary, W.J.; Rich, J.A.; Rodriguez, L.L.

    1984-10-01

    This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1983. Papers published in 1982 are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted - even those papers, themselves unclassified, which were published only as part of a classified document. If a paper was published more than once, all places of publication are included. The bibliography includes Los Alamos National Laboratory reports, papers released as non-Laboratory reports, journal articles, books, chapters of books, conference papers either published separately or as part of conference proceedings issued as books or reports, papers publishd in congressional hearings, theses, and US patents. Publications by Los Alamos authors that are not records of Laboratory-sponsored work are included when the Library becomes aware of them.

  13. Status of Monte Carlo at Los Alamos

    SciTech Connect

    Thompson, W.L.; Cashwell, E.D.

    1980-01-01

    At Los Alamos the early work of Fermi, von Neumann, and Ulam has been developed and supplemented by many followers, notably Cashwell and Everett, and the main product today is the continuous-energy, general-purpose, generalized-geometry, time-dependent, coupled neutron-photon transport code called MCNP. The Los Alamos Monte Carlo research and development effort is concentrated in Group X-6. MCNP treats an arbitrary three-dimensional configuration of arbitrary materials in geometric cells bounded by first- and second-degree surfaces and some fourth-degree surfaces (elliptical tori). Monte Carlo has evolved into perhaps the main method for radiation transport calculations at Los Alamos. MCNP is used in every technical division at the Laboratory by over 130 users about 600 times a month accounting for nearly 200 hours of CDC-7600 time.

  14. Publications of Los Alamos research 1980

    SciTech Connect

    Salazar, C.A.; Willis, J.K.

    1981-09-01

    This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1980. Papers published in 1980 are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted-even those papers, themselves unclassified, which were published only as part of a classified document. If a paper was pubished more than once, all places of publication are included. The bibliography includes Los Alamos National Laboratory reports, papers released as non-laboratory reports, journal articles, books, chapters of books, conference papers published either separately or as part of conference proceedings issued as books or reports, papers published in congressional hearings, theses, and US patents. Publications by Los Alamos authors that are not records of Laboratory-sponsored work are included when the Library becomes aware of them.

  15. New Generation of Los Alamos Opacity Tables

    NASA Astrophysics Data System (ADS)

    Colgan, James; Kilcrease, D. P.; Magee, N. H.; Sherrill, M. E.; Abdallah, J.; Hakel, P.; Fontes, C. J.; Guzik, J. A.; Mussack, K. A.

    2016-05-01

    We present a new generation of Los Alamos OPLIB opacity tables that have been computed using the ATOMIC code. Our tables have been calculated for all 30 elements from hydrogen through zinc and are publicly available through our website. In this poster we discuss the details of the calculations that underpin the new opacity tables. We also show several recent applications of the use of our opacity tables to solar modeling and other astrophysical applications. In particular, we demonstrate that use of the new opacities improves the agreement between solar models and helioseismology, but does not fully resolve the long-standing `solar abundance' problem. The Los Alamos National Laboratory is operated by Los Alamos National Security, LLC for the National Nuclear Security Administration of the U.S. Department of Energy under Contract No. DE-AC5206NA25396.

  16. Actitud y conocimiento sobre donación de órganos de estudiantes de medicina de una universidad pública del noreste de México.

    PubMed

    Sebastián-Ruiz, María José; Guerra-Sáenz, Elda Karina; Vargas-Yamanaka, Anna Karen; Barboza-Quintana, Oralia; Ríos-Zambudio, Antonio; García-Cabello, Ricardo; Palacios-Saucedo, Gerardo Del Carmen

    2017-01-01

    Averiguar la actitud y el conocimiento que tienen los estudiantes de medicina de una universidad pública del noreste de México sobre la donación de órganos y tejidos. Estudio prolectivo, descriptivo, observacional y transversal. Se incluyeron 3056 encuestas de 34 reactivos realizadas a estudiantes de medicina durante el periodo 2013-2015 y se eliminaron aquellas con menos del 80% de los reactivos contestados. Análisis estadístico: frecuencias absolutas, porcentajes, medias, desviación estándar y prueba de ji al cuadrado. Se consideró significativo un valor de p < 0.05. El 74% de los estudiantes donaría sus órganos y el 41% lo haría por reciprocidad; del 26% que no donaría sus órganos, el 48% no lo haría por temor a que tomen sus órganos antes de estar muerto. Un 86% estaría dispuesto a donar los órganos de algún familiar. El 64% ha comentado el tema de la donación con su familia y el 67% con amigos. El 50% no ha recibido información alguna sobre el tema. El 68% entiende el concepto de muerte encefálica. Pocos estudiantes reciben información sobre donación de órganos al llegar a la universidad; pese a ello, la mayoría tiene una actitud positiva y estarían -dispuestos a -donar. The issue of organ donation is scarcely addressed during undergraduate medical studies. To evaluate the knowledge and attitude towards organ donation of medicine students of a Northwestern Mexico public university. A prolective, descriptive, observational, and cross-sectional study. A 34 items cross-sectional survey evaluating knowledge and attitude towards organ donation in 3056 medicine students during 2013-2015. Descriptive statistics were used as absolute frequencies, percentages, mean and standard deviation, as well as the Chi-square test. A p < 0.05 was considered significant. 74% of students would donate their own organs, mainly due to reciprocity (41%). 26% of students would not donate, 48% of them because of fear that their organs could be taken before death

  17. Ballona Creek and Tributaries, Los Angeles County Drainage Area, California.

    DTIC Science & Technology

    1982-12-01

    7AD-AiSI 322 BALLONA CREEK AND TRIBUTARIES LOS ANGELES COUNTYii DRAINAGE AREA CALIFORNIA(U) ARMY ENGINEER DISTRICT LOS ANGELES CA DEC 82 UNCLASSIFIED...FesbltyRpf for of Engineers Faiiiy~pr o Los Angeles District Ballona Creek and Tributaries In LOS ANGELES COUNTY DRAINAGE AREA, CALIFORNIA ~EB14 Y85... DRAINAGE AREA, CALIFORNIA INTERIM FEASIBILITY REPORT FOR BALLONA CREEK AND TRIBUTARIES U.S. ARMY CORPS OF ENGINEERS LOS ANGELES DECEMBER 1982 C "L --i

  18. A Sailor in the Los Alamos Navy

    SciTech Connect

    Judd, D. L.

    2016-12-20

    As part of the War Department’s Manhattan Engineer District (MED), Los Alamos was an Army installation during World War II, complete with a base commander and a brace of MPs. But it was a unique Army installation, having more civilian then military personnel. Even more unique was the work performed by the civilian population, work that required highly educated scientists and engineers. As the breadth, scope, and complexity of the Laboratory’s work increased, more and more technically educated and trained personnel were needed. But, the manpower needs of the nation’s war economy had created a shortage of such people. To meet its manpower needs, the MED scoured the ranks of the Army for anyone who had technical training and reassigned these men to its laboratories, including Los Alamos, as part of its Special Engineer Detachment (SED). Among the SEDs assigned to Los Alamos was Val Fitch, who was awarded the Nobel Prize in Physics in 1980. Another was Al Van Vessem, who helped stack the TNT for the 100 ton test, bolted together the Trinity device, and rode shotgun with the bomb has it was driven from Los Alamos to ground zero.

  19. Los Angeles County Parks and Recreation.

    ERIC Educational Resources Information Center

    Iowa Univ., Iowa City. Recreation Education Program.

    Presented are duplications of the responses given by the Los Angeles County Parks and Recreation Rehabilitation Unit (California) as part of a project to collect, share, and compile information about, and techniques in the operation of 18 community action models for recreation services to the disabled. Model programs are categorized as consumer,…

  20. Integration and Decentralization in Los Angeles

    ERIC Educational Resources Information Center

    Johnston, William J.

    1971-01-01

    An answer to an article by John Caughey in the July-August issue of Integrated Education." The Superintendent of Schools, Los Angeles City Schools, explains the nature of the twelve administrative areas in the city--areas intended to be responsive to local needs, yet not functioning autonomously. (JM)

  1. Small mammals from Sima de los Huesos.

    PubMed

    Cuenca-Bescós, G; Laplana Conesa, C; Canudo, J I; Arsuaga, J L

    1997-01-01

    A small collection of rodents from Sima de los Huesos helps to clarify the stratigraphic position of this famous human locality. The presence of Allocricetus bursae and Pliomys lenki relictus and the size of A. bursae, Apodemus sylvaticus and Eliomys quercinus suggest a Middle Pleistocene age (Saalian) to the Clays where humans have been found.

  2. New Management Thrust at Los Rios

    ERIC Educational Resources Information Center

    Klapstein, Earl L.

    1978-01-01

    Describes the management practices adopted by the Los Rios Community College District (California) as a result of the passage of the Jarvis-Gann tax initiative. Alterations included reorganization of upper management structure, full budget disclosures, collective bargaining, merit pay concept for administrative staff, and the creation of a…

  3. Race, Reading, and Proverty in Los Angeles

    ERIC Educational Resources Information Center

    Payne, Joseph F.

    1971-01-01

    Correlation analysis of reading score rankings of all the elementary, unified, and high school districts in Los Angeles County discloses a strong negative relation between proportion of minority students and rank, and proportion of students receiving welfare aid and rank. (JM)

  4. Significant Silence in Elena Garro's "Los Perros"

    ERIC Educational Resources Information Center

    Burke, Jessica

    2010-01-01

    Elena Garro's one-act play "Los perros" (1958) confronts the difficult issue of sexual violence in rural Mexico, a problem that persists today. The characters struggle with the social reality of rape, alluding to the threat of sexual violence while avoiding addressing it directly. While words are granted an almost magical power in…

  5. Los Angeles Settles ACLU Suit on Layoffs

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2010-01-01

    A settlement crafted last week seeking to curb the use of seniority as a factor in teacher layoffs in the Los Angeles school system could become one of the nation's most far-reaching overhauls of the "last hired, first fired" policies common in school districts. If approved by a judge, the settlement would shield up to 45 low-performing…

  6. Induction inserts at the Los Alamos PSR

    SciTech Connect

    King-Yuen Ng

    2002-09-30

    Ferrite-loaded induction tuners installed in the Los Alamos Proton Storage Ring have been successful in compensating space-charge effects. However, the resistive part of the ferrite introduces unacceptable microwave instability and severe bunch lengthening. An effective cure was found by heating the ferrite cores up to {approx} 130 C. An understanding of the instability and cure is presented.

  7. Latina Adolescent Childbearing in East Los Angeles.

    ERIC Educational Resources Information Center

    Erickson, Pamela I.

    This book is about teenage pregnancy among Latina teenagers in East Los Angeles (California). It focuses on teenage pregnancy and motherhood among economically disadvantaged Latinas aged 17 and under. The young mothers in this study were participants in a series of intervention efforts to prevent repeat pregnancy at a family planning clinic. This…

  8. Significant Silence in Elena Garro's "Los Perros"

    ERIC Educational Resources Information Center

    Burke, Jessica

    2010-01-01

    Elena Garro's one-act play "Los perros" (1958) confronts the difficult issue of sexual violence in rural Mexico, a problem that persists today. The characters struggle with the social reality of rape, alluding to the threat of sexual violence while avoiding addressing it directly. While words are granted an almost magical power in…

  9. Minorities in Suburbs: The Los Angeles Experience.

    ERIC Educational Resources Information Center

    Rabinovitz, Francine F.; Siembieda, William J.

    This book focuses on black suburbanization in the Los Angeles area, and questions whether the national increase in black suburbanization should be viewed with optimism or pessimism. The study addresses three questions: (1) Does the presence of substantial black populations in suburban areas represent suburbanization as it is normally thought of,…

  10. Latina Adolescent Childbearing in East Los Angeles.

    ERIC Educational Resources Information Center

    Erickson, Pamela I.

    This book is about teenage pregnancy among Latina teenagers in East Los Angeles (California). It focuses on teenage pregnancy and motherhood among economically disadvantaged Latinas aged 17 and under. The young mothers in this study were participants in a series of intervention efforts to prevent repeat pregnancy at a family planning clinic. This…

  11. Small Business Among Koreans in Los Angeles.

    ERIC Educational Resources Information Center

    Bonacich, Edna; And Others

    The purpose of this paper is to describe the character of small business among Koreans in Los Angeles, to examine the means by which Koreans are able to enter small business in an economy which clearly is moving in the opposite direction, and to consider why it is that immigrant small business should flourish within monopoly capitalism. Korean…

  12. Los Alamos Fires From Landsat 7

    NASA Technical Reports Server (NTRS)

    2002-01-01

    On May 9, 2000, the Landsat 7 satellite acquired an image of the area around Los Alamos, New Mexico. The Landsat 7 satellite acquired this image from 427 miles in space through its sensor called the Enhanced Thematic Mapper Plus (ETM+). Evident within the imagery is a view of the ongoing Cerro Grande fire near the town of Los Alamos and the Los Alamos National Laboratory. Combining the high-resolution (30 meters per pixel in this scene) imaging capacity of ETM+ with its multi-spectral capabilities allows scientists to penetrate the smoke plume and see the structure of the fire on the surface. Notice the high-level of detail in the infrared image (bottom), in which burn scars are clearly distinguished from the hotter smoldering and flaming parts of the fire. Within this image pair several features are clearly visible, including the Cerro Grande fire and smoke plume, the town of Los Alamos, the Los Alamos National Laboratory and associated property, and Cerro Grande peak. Combining ETM+ channels 7, 4, and 2 (one visible and two infrared channels) results in a false color image where vegetation appears as bright to dark green (bottom image). Forested areas are generally dark green while herbaceous vegetation is light green. Rangeland or more open areas appear pink to light purple. Areas with extensive pavement or urban development appear light blue or white to purple. Less densely-developed residential areas appear light green and golf courses are very bright green. The areas recently burned appear black. Dark red to bright red patches, or linear features within the burned area, are the hottest and possibly actively burning areas of the fire. The fire is spreading downslope and the front of the fire is readily detectable about 2 kilometers to the west and south of Los Alamos. Combining ETM+ channels 3, 2, and 1 provides a true-color image of the greater Los Alamos region (top image). Vegetation is generally dark to medium green. Forested areas are very dark green

  13. Sobre os sistemas de referência celeste

    NASA Astrophysics Data System (ADS)

    Poppe, P. C. R.; Martin, V. A. F.

    2003-02-01

    Apresentamos neste trabalho, algumas discussões sobre os sistemas de referência utilizados em Astronomia. Claramente, não é possível esgotar todo este assunto num único texto, mas esperamos, contudo, que o presente material possa ser apreciado nos cursos de Introdução à Astronomia, que estão cada vez mais presentes nas atuais propostas curriculares das graduações de Física. As discussões pertinentes às "Bases de Referência Celeste", serão apresentadas em um outro trabalho.

  14. Cambios históricos en el aporte terrígeno de la cuenca del Río de la Plata sobre la plataforma interna Uruguaya

    NASA Astrophysics Data System (ADS)

    Marrero, Analía; Tudurí, Adriana; Pérez, Laura; Cuña, Caroline; Muniz, Pablo; Lopes Figueira, Rubens; Michaelovitch de Mahiques, Michel; Alves de Lima Ferreira, Paulo; Pittauerová, Daniela; Hanebuth, Till; García Rodríguez, Felipe

    2014-12-01

    El Río de la Plata (RdlP) presenta significativas variaciones naturales (hidrodinámicas y oceanográficas) asociadas a diferentes condiciones climáticas. El propósito de este trabajo es inferir los cambios de aportes continentales de sedimentos y su relación con las variaciones hidrológicas del Río de la Plata, a través del análisis de proxies sedimentológicos y geoquímicos en testigos de sedimentos de la plataforma interna uruguaya que registran los últimos 100 años, aproximadamente. A partir de la datación por 210Pb de dos testigos de sedimentos (GeoB 13813-4 y BAR1) se reconstruyó la geocronología del ambiente, y se relacionó con datos de las forzantes climáticas Pacific Decadal Oscillation, El Niño/La Niña Southern Oscillation, Atlantic Multidecadal Oscillation, y las anomalías hidrológicas de los ríos Paraná y Uruguay. Los valores más positivos y estables del Southern Oscillation Index, los cuales corresponden a fases La Niña, se observan en el periodo correspondiente entre 1910-1970, respecto al resto de la serie, donde se aprecia una mayor variabilidad y una tendencia hacia valores más negativos (eventos El Niño). Se hicieron dendrogramas (clustering) jerárquicos para ambos testigos. Para el testigo GeoB 13813-4, se utilizó la relación Ca/Ti y la granulometría, mientras que para BAR1 se recurrió a variables granulométricas y la tasa de sedimentación. El mayor aporte continental hacia la región de la plataforma adyacente al Río de la Plata registrado a partir del año 1970, podría ser el factor principal de los agrupamientos observados en los clusters para ambos testigos. Las agrupaciones mostraron una diferenciación en la década de 1970, lo que estaría asociado al aumento de los caudales de los ríos Paraná y Uruguay, durante las últimas tres décadas del siglo XX. Por otra parte se observa que la granulometría del testigo BAR1 presentó un mayor tamaño de grano y más variabilidad que en el caso del testigo Geo

  15. Water supply at Los Alamos during 1992

    SciTech Connect

    Purtymun, W.D.; McLin, S.G.; Stoker, A.K.; Maes, M.N.

    1995-09-01

    Municipal potable water supply during 1992 was 1,516 {times} 10{sup 6} gallons from wells in the Guaje and Pajarito well fields. About 13 {times} 10{sup 6} gallons were pumped from the Los Alamos Well Field and used in the construction of State Road 501 adjacent to the Field. The last year the Las Alamos Field was used for municipal supply was 1991. The nonpotable water supply used for steam plant support was about 0.12 {times} 10{sup 6} gallons from the spring gallery in Water Canyon. No nonpotable water was used for irrigation from Guaje and Los Alamos Reservoirs. Thus, the total water usage in 1992 was about 1,529 {times} 10{sup 6} gallons. Neither of the two new wells in the Otowi Well Field were operational in 1992.

  16. Facilitating LOS Debriefings: A Training Manual

    NASA Technical Reports Server (NTRS)

    McDonnell, Lori K.; Jobe, Kimberly K.; Dismukes, R. Key

    1997-01-01

    This manual is a practical guide to help airline instructors effectively facilitate debriefings of Line Oriented Simulations (LOS). It is based on a recently completed study of Line Oriented Flight Training (LOFT) debriefings at several U.S. airlines. This manual presents specific facilitation tools instructors can use to achieve debriefing objectives. The approach of the manual is to be flexible so it can be tailored to the individual needs of each airline. Part One clarifies the purpose and objectives of facilitation in the LOS setting. Part Two provides recommendations for clarifying roles and expectations and presents a model for organizing discussion. Part Tree suggests techniques for eliciting active crew participation and in-depth analysis and evaluation. Finally, in Part Four, these techniques are organized according to the facilitation model. Examples of how to effectively use the techniques are provided throughout, including strategies to try when the debriefing objectives are not being fully achieved.

  17. Water Supply at Los Alamos during 1997

    SciTech Connect

    M. N. Maes; S. G. McLin; W. D. Purtymun

    1998-12-01

    Production of potable municipal water supplies during 1997 totaled about 1,285.9 million gallons from wells in the Guaje, Pajarito, and Otowi well fields. There was no water used from the spring gallery in Water Canyon or from Guaje Reservoir during 1997. About 2.4 million gallons of water from Los Alamos Reservoir was used to irrigate public parks and recreational lands. The total water usage in 1997 was about 1,288.3 million gallons, or about 135 gallons per day per person living in Los Alamos County. Groundwater pumpage was down about 82.2 million gallons in 1997 compared with the pumpage in 1996. Four new replacement wells were drilled and cased in Guaje Canyon between October 1997 and March 1998. These wells are currently being developed and aquifer tests are being performed. A special report summarizing the geological, geophysical, and well construction logs will be issued in the near future for these new wells.

  18. Geochemistry of Los Humeros Caldera, Puebla, Mexico

    NASA Astrophysics Data System (ADS)

    Verma, S. P.; Lopez, M.

    1982-03-01

    Geochemistry of Pliocene to recent volcanic rocks from Los Humeros caldera (19°30' N - 19°50' N and 97°15° W - 97°35' W) in East-Central mexico is described. The volcanic rocks from this area seem to represent both alkali and high-alumina basalt series, or both calcalkaline and high-K calc-alkaline sequences. The available bulk-chemical analyses (23 this study and 18 from unpublished literature) show that the entire sequence of rocks from basalts to rhyolites are present in this area. Different degrees of partial melting of the source region followed by extensive shallow-level crystal differentiation seem to have taken place before most volcanic eruptions. These processes are perhaps the most important mechanisms for magma genesis in Los Humeros caldera. Geophysical studies in this area are not sufficient and more detailed geophysical surveys and a better geological interpretation are needed in order to delimit the underlying magma chamber.

  19. Nuclear Forensics at Los Alamos National Laboratory

    SciTech Connect

    Podlesak, David W; Steiner, Robert E.; Burns, Carol J.; LaMont, Stephen P.; Tandon, Lav

    2012-08-09

    The overview of this presentation is: (1) Introduction to nonproliferation efforts; (2) Scope of activities at Los Alamos National Laboratory; (3) Facilities for radioanalytical work at LANL; (4) Radiochemical characterization capabilities; and (5) Bulk chemical and materials analysis capabilities. Some conclusions are: (1) Analytical chemistry measurements on plutonium and uranium matrices are critical to numerous defense and non-defense programs including safeguards accountancy verification measurements; (2) Los Alamos National Laboratory operates capable actinide analytical chemistry and material science laboratories suitable for nuclear material forensic characterization; (3) Actinide analytical chemistry uses numerous means to validate and independently verify that measurement data quality objectives are met; and (4) Numerous LANL nuclear facilities support the nuclear material handling, preparation, and analysis capabilities necessary to evaluate samples containing nearly any mass of an actinide (attogram to kilogram levels).

  20. Recent Infrasound Calibration Activity at Los Alamos

    NASA Astrophysics Data System (ADS)

    Whitaker, R. W.; Marcillo, O. E.

    2014-12-01

    Absolute infrasound sensor calibration is necessary for estimating source sizes from measured waveforms. This can be an important function in treaty monitoring. The Los Alamos infrasound calibration chamber is capable of absolute calibration. Early in 2014 the Los Alamos infrasound calibration chamber resumed operations in its new location after an unplanned move two years earlier. The chamber has two sources of calibration signals. The first is the original mechanical piston, and the second is a CLD Dynamics Model 316 electro-mechanical unit that can be digitally controlled and provide a richer set of calibration options. During 2008-2010 a number of upgrades were incorporated for improved operation and recording. In this poster we give an overview of recent chamber work on sensor calibrations, calibration with the CLD unit, some measurements with different porous hoses and work with impulse sources.

  1. Los Angeles County Poor Farm, Patient Wards 201, 202, 203, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Wards 201, 202, 203, 204, 205, 206, 207, 208 & 209 - Type A Plan, 7601 Imperial Highway; bounded by Esperanza Street, Hawthorn Avenue, Laurel Street, and Descanso Street, Downey, Los Angeles County, CA

  2. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  3. 78 FR 68135 - Environmental Impact Statement: Los Angeles County, California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... Federal Highway Administration Environmental Impact Statement: Los Angeles County, California AGENCY... Environmental Impact Statement will be prepared for a proposed highway project in Los Angeles County, California... the assigned National Environmental Policy Act (NEPA) agency will prepare an Environmental Impact...

  4. 76 FR 13017 - Environmental Impact Statement: Los Angeles County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... Federal Highway Administration Environmental Impact Statement: Los Angeles County, CA AGENCY: Federal... Environmental Impact Statement will be prepared for a proposed highway project in Los Angeles County, California... District Director, California Department of Transportation, District 7, Division of Environmental Planning...

  5. Los Alamos Novel Rocket Design Flight Tested

    ScienceCinema

    Tappan, Bryce

    2016-07-12

    Los Alamos National Laboratory scientists recently flight tested a new rocket design that includes a high-energy fuel and a motor design that also delivers a high degree of safety. Researchers will now work to scale-up the design, as well as explore miniaturization of the system, in order to exploit all potential applications that would require high-energy, high-velocity, and correspondingly high safety margins.

  6. Los Alamos Novel Rocket Design Flight Tested

    SciTech Connect

    Tappan, Bryce

    2014-10-23

    Los Alamos National Laboratory scientists recently flight tested a new rocket design that includes a high-energy fuel and a motor design that also delivers a high degree of safety. Researchers will now work to scale-up the design, as well as explore miniaturization of the system, in order to exploit all potential applications that would require high-energy, high-velocity, and correspondingly high safety margins.

  7. Los bosques de Puerto Rico, 2009

    Treesearch

    Humfredo Marcano Vega; Thomas J. Brandeis; Jeffery A. Turner; No Other

    2015-01-01

    Este informe presenta los resultados del cuarto inventario forestal de las islas del Estado Libre Asociado de Puerto Rico. El área de bosque en la isla grande de Puerto Rico se mantuvo constante o aumentó ligeramente del año 2004 al 2009. Este cambio parece indicar que la tasa de incremento de cubierta forestal en la isla grande de Puerto Rico ha disminuido desde que...

  8. Amphibians and Reptiles of Los Alamos County

    SciTech Connect

    Teralene S. Foxx; Timothy K. Haarmann; David C. Keller

    1999-10-01

    Recent studies have shown that amphibians and reptiles are good indicators of environmental health. They live in terrestrial and aquatic environments and are often the first animals to be affected by environmental change. This publication provides baseline information about amphibians and reptiles that are present on the Pajarito Plateau. Ten years of data collection and observations by researchers at Los Alamos National Laboratory, the University of New Mexico, the New Mexico Department of Game and Fish, and hobbyists are represented.

  9. Wolf Fire West of Los Angeles

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This photograph taken from the International Space Station on June 7, 2002, shows the Copper Fire burning in the hills outside Los Angeles. Astronauts use a variety of lenses and look angles as their orbits pass over wildfires to document the long-distance movements of smoke from the fires as well as details of the burning areas. This image clearly illustrates the difficult, rugged terrain that firefighters must face when fighting these wildland fires.

  10. Los Alamos Team Demonstrates Bottle Scanner Technology

    SciTech Connect

    Espy, Michelle; Schultz, Larry

    2014-05-06

    Los Alamos scientists are demonstrating a Nuclear Magnetic Resonance Imaging (NMR) technology that may provide a breakthrough for screening liquids at airport security. By adding low-power X-ray data to the NMR mix, scientists believe they have unlocked a new detection technology. Funded in part by the Department of Homeland Security's Science and Technology Directorate, the new technology is called MagRay.

  11. The Los Alamos accelerator code group

    SciTech Connect

    Krawczyk, F.L.; Billen, J.H.; Ryne, R.D.; Takeda, Harunori; Young, L.M.

    1995-05-01

    The Los Alamos Accelerator Code Group (LAACG) is a national resource for members of the accelerator community who use and/or develop software for the design and analysis of particle accelerators, beam transport systems, light sources, storage rings, and components of these systems. Below the authors describe the LAACG`s activities in high performance computing, maintenance and enhancement of POISSON/SUPERFISH and related codes and the dissemination of information on the INTERNET.

  12. Los Alamos National Laboratory Facility Review

    SciTech Connect

    Nelson, Ronald Owen

    2015-06-05

    This series of slides depicts the Los Alamos Neutron Science Center (LANSCE). The Center's 800-MeV linac produces H+ and H- beams as well as beams of moderated (cold to 1 MeV) and unmoderated (0.1 to 600 MeV) neutrons. Experimental facilities and their capabilities and characteristics are outlined. Among these are LENZ, SPIDER, and DANCE.

  13. Los Alamos Team Demonstrates Bottle Scanner Technology

    ScienceCinema

    Espy, Michelle; Schultz, Larry

    2016-07-12

    Los Alamos scientists are demonstrating a Nuclear Magnetic Resonance Imaging (NMR) technology that may provide a breakthrough for screening liquids at airport security. By adding low-power X-ray data to the NMR mix, scientists believe they have unlocked a new detection technology. Funded in part by the Department of Homeland Security's Science and Technology Directorate, the new technology is called MagRay.

  14. Risk management at Los Alamos National Laboratory

    SciTech Connect

    Brooks, D.G.; Stack, D.W.

    1993-11-01

    Los Alamos National Laboratory has risk management programs at a number of administrative levels. Each line organization has responsibility for risk management for routine operations. The Facility Risk Management group (HS-3) is the Los Alamos organization with the primary responsibility for risk management including providing input and expertise to facilities and line managers in the management and documentation of ES&H hazards and risks associated with existing and new activities. One of the major contributions this group has made to laboratory risk management program is to develop and implement a hazard identification and classification methodology that is readily adaptable to continuously changing classification guidelines such as DOE-STD-1027. The increased emphasis on safety at Los Alamos has led to the formation of additional safety oversight organization such as the Integration and Coordination Office (ICO), which is responsible for prioritization of risk management activities. In the fall of 1991, nearly 170 DOE inspectors spent 6 weeks analyzing the environmental, safety, and health activities at Los Alamos. The result of this audit was a list of over 1000 findings, each indicating some deficiency in current Laboratory operations relative to DOE and other government regulation. The audit team`s findings were consolidated and ``action plans`` were developed to address the findings. This resulted in over 200 action plans with a total estimated cost of almost $1 billion. The Laboratory adopted a risk-based prioritization process to attempt to achieve as much risk reduction as possible with the available resources. This paper describes the risk based prioritization model that was developed.

  15. Los Alamos National Laboratory Building Cost Index

    SciTech Connect

    Orr, H.D.; Lemon, G.D.

    1983-01-01

    The Los Alamos National Laboratory Building Cost Index indicates that actual escalation since 1970 is near 10% per year. Therefore, the Laboratory will continue using a 10% per year escalation rate for construction estimates through 1985 and a slightly lower rate of 8% per year from 1986 through 1990. The computerized program compares the different elements involved in the cost of a typical construction project, which for our purposes, is a complex of office buildings and experimental laboratores. The input data used in the program consist primarily of labor costs and material and equipment costs. The labor costs are the contractural rates of the crafts workers in the Los Alamos area. For the analysis, 12 field-labor draft categories are used; each is weighted corresponding to the labor craft distribution associated with the typical construction project. The materials costs are current Los Alamos prices. Additional information sources include material and equipment quotes obtained through conversations with vendors and from trade publications. The material and equipment items separate into 17 categories for the analysis and are weighted corresponding to the material and equipment distribution associated with the typical construction project. The building cost index is compared to other national building cost indexes.

  16. Los Alamos National Laboratory building cost index

    SciTech Connect

    Orr, H.D.; Lemon, G.D.

    1982-10-01

    The Los Alamos National Laboratory Building Cost Index indicates that actual escalation since 1970 is near 10% per year. Therefore, the Laboratory will continue using a 10% per year escalation rate for construction estimates through 1985 and a slightly lower rate of 8% per year from 1986 through 1990. The computerized program compares the different elements involved in the cost of a typical construction project, which for our purposes, is a complex of office buildings and experimental laboratories. The input data used in the program consist primarily of labor costs and material and equipment costs. The labor costs are the contractual rates of the crafts workers in the Los Alamos area. For the analysis, 12 field-labor craft categories are used; each is weighted corresponding to the labor craft distribution associated with the typical construction project. The materials costs are current Los Alamos prices. Additional information sources include material and equipment quotes obtained through conversations with vendors and from trade publications. The material and equipment items separate into 17 categories for the analysis and are weighted corresponding to the material and equipment distribution associated with the typical construction project. The building cost index is compared to other national building cost indexes.

  17. Space Radar Image of Los Angeles, California

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This radar image shows the massive urbanization of Los Angeles, California. The image extends from the Santa Monica Bay at the left to the San Gabriel Mountains at the right. Downtown Los Angeles is in the center of the image. The runways of the Los Angeles International Airport appear as black strips at the left center of the image. The waterways of Marina del Rey are seen just above the airport. The San Gabriel Mountains and the city of Pasadena are at the right center of the image. Black areas on the mountains on the right are fire scars from the 1993 Altadena fire. The Rose Bowl is shown as a small circle near the right center. The complex freeway system is visible as dark lines throughout the image. Some city areas, such as Santa Monica in the upper left, appear red due to the alignment of streets and buildings to the incoming radar beam. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) onboard the space shuttle Endeavour on October 3, 1994. SIR-C/X-SAR, a joint mission of the German, Italian and the United States space agencies, is part of NASA's Mission to Planet Earth. This image is centered at 34.04 degrees North latitude and 118.2 degrees West longitude with North pointing toward the upper right. The area shown measures 40 kilometers by 50 kilometers (25 miles by 31 miles).

  18. Critical partnerships: Los Alamos, universities, and industry

    SciTech Connect

    Berger, C.L.

    1997-04-01

    Los Alamos National Laboratory, situated 35 miles northwest of Santa Fe, NM, is one of the Department of Energy`s three Defense Programs laboratories. It encompasses 43 square miles, employees approximately 10,000 people, and has a budget of approximately $1.1B in FY97. Los Alamos has a strong post-cold war mission, that of reducing the nuclear danger. But even with that key role in maintaining the nation`s security, Los Alamos views partnerships with universities and industry as critical to its future well being. Why is that? As the federal budget for R&D comes under continued scrutiny and certain reduction, we believe that the triad of science and technology contributors to the national system of R&D must rely on and leverage each others capabilities. For us this means that we will rely on these partners to help us in 5 key ways: We expect that partnerships will help us maintain and enhance our core competencies. In doing so, we will be able to attract the best scientists and engineers. To keep on the cutting edge of research and development, we have found that partnerships maintain the excellence of staff through new and exciting challenges. Additionally, we find that from our university and corporate partners we often learn and incorporate {open_quotes}best practices{close_quotes} in organizational management and operations. Finally, we believe that a strong national system of R&D will ensure and enhance our ability to generate revenues.

  19. Primeros resultados sobre el estudio de oscilaciones no radiales

    NASA Astrophysics Data System (ADS)

    Córsico, A.; Benvenuto, O. G.

    En el Observatorio de La Plata se ha comenzado a elaborar un código de pulsaciones el cual resuelve el problema de las oscilaciones no radiales en el caso adiabático. Dicho código está basado en la técnica de diferencias finitas ampliamente usado en cálculos de estructura y evolución estelar. En este trabajo se presentan los primeros resultados encontrados aplicando el código mencionado al caso de una polítropa de índice n=3. Se presentan los valores de las autofrecuencias y las autofunciones para diferentes modos de pulsación de dicha configuración politrópica. En un futuro próximo, se aplicará este programa al estudio de las pulsaciones no radiales de estrellas enanas blancas.

  20. Los plaguicidas y la contaminacion del medio ambiente Venezolano

    USGS Publications Warehouse

    Stickel, L.F.; Stickel, W.H.

    1972-01-01

    RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

  1. Space Radar Image of Los Angeles, California

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This is a radar image of Los Angeles, California, taken on October 2, 1994. Visible in the image are Long Beach Harbor at the bottom right (south corner of the image), Los Angeles International Airport at the bottom center, with Santa Monica just to the left of it and the Hollywood Hills to the left of Santa Monica. Also visible in the image are the freeway systems of Los Angeles, which appear as dark lines. The San Gabriel Mountains (center top) and the communities of San Fernando Valley, Simi Valley and Palmdale can be seen on the left-hand side. This image was acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 24th orbit. The image is centered at 34 degrees north latitude, 118 degrees west longitude. The area shown is approximately 100 kilometers by 52 kilometers (62 miles by 32 miles). This single-frequency SIR-C image was obtained by the L-band (24 cm) radar channel, horizontally transmitted and received. Portions of the Pacific Ocean visible in this image appear very dark as do freeways and other flat surfaces such as the airport runways. Mountains in the image are dark grey, with brighter patches on the mountain slopes, which face in the direction of the radar illumination (from the top of the image). Suburban areas, with the low-density housing and tree-lined streets that are typical of Los Angeles, appear as lighter grey. Areas with high-rise buildings, such as downtown Los Angeles, appear in very bright white, showing a higher density of housing and streets which run parallel to the radar flight track. Scientists hope to use radar image data from SIR-C/X-SAR to map fire scars in areas prone to brush fires, such as Los Angeles. In this image, the Altadena fire area is visible in the top center of the image as a patch of mountainous terrain which is slightly darker than the nearby mountains. Using all the radar frequency and polarization images provided by SIR

  2. Space Radar Image of Los Angeles, California

    NASA Image and Video Library

    1999-04-15

    This radar image shows the massive urbanization of Los Angeles, California. The image extends from the Santa Monica Bay at the left to the San Gabriel Mountains at the right. Downtown Los Angeles is in the center of the image. The runways of the Los Angeles International Airport appear as black strips at the left center of the image. The waterways of Marina del Rey are seen just above the airport. The San Gabriel Mountains and the city of Pasadena are at the right center of the image. Black areas on the mountains on the right are fire scars from the 1993 Altadena fire. The Rose Bowl is shown as a small circle near the right center. The complex freeway system is visible as dark lines throughout the image. Some city areas, such as Santa Monica in the upper left, appear red due to the alignment of streets and buildings to the incoming radar beam. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) onboard the space shuttle Endeavour on October 3, 1994. SIR-C/X-SAR, a joint mission of the German, Italian and the United States space agencies, is part of NASA's Mission to Planet Earth. This image is centered at 34.04 degrees North latitude and 118.2 degrees West longitude with North pointing toward the upper right. The area shown measures 40 kilometers by 50 kilometers (25 miles by 31 miles). http://photojournal.jpl.nasa.gov/catalog/PIA01789

  3. Los Alamos Before and After the Fire

    NASA Technical Reports Server (NTRS)

    2002-01-01

    On May 4, 2000, a prescribed fire was set at Bandelier National Monument, New Mexico, to clear brush and dead and dying undergrowth to prevent a larger, subsequent wildfire. Unfortunately, due to high winds and extremely dry conditions in the surrounding area, the prescribed fire quickly raged out of control and, by May 10, the blaze had spread into the nearby town of Los Alamos. In all, more than 20,000 people were evacuated from their homes and more than 200 houses were destroyed as the flames consumed about 48,000 acres in and around the Los Alamos area. The pair of images above were acquired by the Enhanced Thematic Mapper Plus (ETM+) sensor, flying aboard NASA's Landsat 7 satellite, shortly before the Los Alamos fire (top image, acquired April 14) and shortly after the fire was extinguished (lower image, June 17). The images reveal the extent of the damage caused by the fire. Combining ETM+ channels 7, 4, and 2 (one visible and two infrared channels) results in a false-color image where vegetation appears as bright to dark green. Forested areas are generally dark green while herbaceous vegetation is light green. Rangeland or more open areas appear pink to light purple. Areas with extensive pavement or urban development appear light blue or white to purple. Less densely-developed residential areas appear light green and golf courses are very bright green. In the lower image, the areas recently burned appear bright red. Landsat 7 data courtesy United States Geological Survey EROS DataCenter. Images by Robert Simmon, NASA GSFC.

  4. Los Alamos National Laboratory strategic directions

    SciTech Connect

    Hecker, S.

    1995-10-01

    It is my pleasure to welcome you to Los Alamos. I like the idea of bringing together all aspects of the research community-defense, basic science, and industrial. It is particularly important in today`s times of constrained budgets and in fields such as neutron research because I am convinced that the best science and the best applications will come from their interplay. If we do the science well, then we will do good applications. Keeping our eye focused on interesting applications will spawn new areas of science. This interplay is especially critical, and it is good to have these communities represented here today.

  5. Environmental Programs at Los Alamos National Laboratory

    SciTech Connect

    Jones, Patricia

    2012-07-11

    Summary of this project is: (1) Teamwork, partnering to meet goals - (a) Building on cleanup successes, (b) Solving legacy waste problems, (c) Protecting the area's environment; (2) Strong performance over the past three years - (a) Credibility from four successful Recovery Act Projects, (b) Met all Consent Order milestones, (c) Successful ramp-up of TRU program; (3) Partnership between the National Nuclear Security Administration's Los Alamos Site Office, DOE Carlsbad Field Office, New Mexico Environment Department, and contractor staff enables unprecedented cleanup progress; (4) Continued focus on protecting water resources; and (5) All consent order commitments delivered on time or ahead of schedule.

  6. Ultraprecision machining of optics at Los Alamos

    SciTech Connect

    Rhorer, R.L.; Gauler, A.L.; Colston, E.W.; Ruhe, J.R.

    1982-01-01

    Ultraprecision machine tools are used at the Los Alamos National Laboratory for single-point diamond turning of optics and other precision parts. Measurements of a 50-mm-diam copper flat illustrate the quality of a part that can be machined on the Moore No. 3 lathe. Measurements of a 0.4-m-diam aluminum mirror with a 20-m radius of curvature are presented as an example of a part machined on the Moore No. 5 lathe. A varying frequency sine wave grating shows a type of special optical grating that can be produced using the Pneumo lathe.

  7. Ultraprecision machining of optics at Los Alamos

    SciTech Connect

    Rhorer, R.L.; Gauler, A.L.; Colston, E.W.; Ruhe, J.R.

    1981-01-01

    Ultraprecision machine tools are used at Los Alamos for single point diamond turning of optics and other precision parts. Measurements of a 50-mm-dia copper flat are used to illustrate the quality of a part which can be machined on the Moore No. 3 lathe. Measurements of a 0.4-m-dia aluminum mirror with a 20-m radius-of-curvature are presented as an example of a part machined on the Moore No. 5 lathe. A varying frequency sine wave grating is used to show a type of special optical grating which can be produced using the Pneumo lathe.

  8. Los Alamos National Laboratory computer benchmarking 1982

    SciTech Connect

    Martin, J.L.

    1983-06-01

    Evaluating the performance of computing machinery is a continual effort of the Computer Research and Applications Group of the Los Alamos National Laboratory. This report summarizes the results of the group's benchmarking activities performed between October 1981 and September 1982, presenting compilation and execution times as well as megaflop rates for a set of benchmark codes. Tests were performed on the following computers: Cray Research, Inc. (CRI) Cray-1S; Control Data Corporation (CDC) 7600, 6600, Cyber 73, Cyber 825, Cyber 835, Cyber 855, and Cyber 205; Digital Equipment Corporation (DEC) VAX 11/780 and VAX 11/782; and Apollo Computer, Inc., Apollo.

  9. Particulate carbon in Los Angeles air.

    PubMed

    Grosjean, D

    1984-01-13

    A selective combustion method has been applied to the determination of total, organic and elemental particulate carbon in Los Angeles air. Carbon concentrations (10-56 micrograms m-3) and their temporal variations are presented for multiday smog episodes. Organic carbon/elemental carbon concentration ratios ranged from approximately 3 during the winter months to approximately 10 during the smog season. Photochemical production of particulate organic carbon is estimated to be approximately 76-118 X 10(3) kg/day, as compared to approximately 31 X 10(3) kg/day from direct emissions. This estimate is also consistent with gas-to-particle conversion considerations for precursor hydrocarbons.

  10. Sistema Solar: de la observación de La Tierra a los planetas gigantes y sus lunas

    NASA Astrophysics Data System (ADS)

    Rodrigo, R.

    La fotoquímica tiene un papel principal en la composición de las atmósferas planetarias. Se examinan diferentes procesos fotoquímicos tanto para atmósferas oxidadas como reductoras, poniendo un especial énfasis en los ciclos químicos más importantes. En este sentido, se presentan diferentes ciclos químicos capaces de producir hidrocarbonos y nitrilos en atmósferas reductoras, así como aquellos capaces de mantener las proporciones de mezcla de las moléculas que contienen oxígeno, tales como CO2, O2 y H2O. También se analizan otros procesos importantes tales como la condensación y procesos de sputtering y de sublimación que han de tenerse en cuenta cuando se realizan modelos sobre la composición atmosférica.

  11. Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico

    NASA Astrophysics Data System (ADS)

    Ramos Pastrana, Nilsa

    El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la

  12. Ecological simulation model of Los Angeles Harbor

    NASA Astrophysics Data System (ADS)

    Kremer, James N.; Kremer, Patricia

    1983-05-01

    A quasi-steady state numerical ecosystem model was designed to help evaluate the potential impact of various scenarios of effluent treatment and of a landfill on the distribution of phytoplankton and inorganic nutrients in Los Angeles and Long Beach harbors Formulations included (a) tidal circulation, (b) phytoplankton growth and oxygen production as a function of temperature, light, and nutrients, (c) grazing by zooplankton, (d) respiration and nutrient regeneration by the benthos, (e) biochemical oxidation of organics, and (f) nitrification Phytoplankton nitrogen, ammonium, nitrate, and oxygen were the state variables, which were simulated with diel and spatial variability for a range of seasonal conditions. Physical circulation was indicated to be a primary factor governing the distribution of state variables, and the landfill resulted in significant alterations. Simulated phytoplankton stocks approximated the upper range of reported concentrations, indicating a satisfactory prediction of bloom conditions. The model indicated that while light may usually regulate maximum phytoplankton levels, under bloom conditions nutrient limitation may also be important Most of the outer Los Angeles Harbor was affected by the effluent, as shown by comparison to the case with zero input Simulations for secondary versus primary treatment converged a short distance from the outfall in response to high BOD oxidation rates. In general, total phytoplankton crop was not greatly affected by the change from primary to secondary treatment, and predation on phytoplankton was small

  13. Glyoxal contribution to aerosols over Los Angeles

    NASA Astrophysics Data System (ADS)

    Balcerak, Ernie

    2012-01-01

    Laboratory and field studies have indicated that glyoxal (chemical formula OCHCHO), an atmospheric oxidation product of isoprene and aromatic compounds, may contribute to secondary organic aerosols in the atmosphere, which can block sunlight and affect atmospheric chemistry. Some aerosols are primary aerosols, emitted directly into the atmosphere, while others are secondary, formed through chemical reactions in the atmosphere. Washenfelder et al. describe in situ glyoxal measurements from Pasadena, Calif., near Los Angeles, made during summer 2010. They used three different methods to calculate the contribution of glyoxal to secondary atmospheric aerosol and found that it is responsible for 0-0.2 microgram per cubic meter, or 0-4%, of the secondary organic aerosol mass. The researchers also compared their results to those of a previous study that calculated the glyoxal contribution to aerosol for Mexico City. Mexico City had higher levels of organic aerosol mass from glyoxal. They suggest that the lower contribution of glyoxal to aerosol concentrations for Los Angeles may be due to differences in the composition or water content of the aerosols above the two cities. (Journal of Geophysical Research-Atmospheres, doi:10.1029/2011JD016314, 2011)

  14. Los Alamos National Laboratory Waste Management Program

    SciTech Connect

    Lopez-Escobedo, G.M.; Hargis, K.M.; Douglass, C.R.

    2007-07-01

    Los Alamos National Laboratory's (LANL) waste management program is responsible for disposition of waste generated by many of the LANL programs and operations. LANL generates liquid and solid waste that can include radioactive, hazardous, and other constituents. Where practical, LANL hazardous and mixed wastes are disposed through commercial vendors; low-level radioactive waste (LLW) and radioactive asbestos-contaminated waste are disposed on site at LANL's Area G disposal cells, transuranic (TRU) waste is disposed at the Waste Isolation Pilot Plant (WIPP), and high-activity mixed wastes are disposed at the Nevada Test Site (NTS) after treatment by commercial vendors. An on-site radioactive liquid waste treatment facility (RLWTF) removes the radioactive constituents from liquid wastes and treated water is released through an NPDES permitted outfall. LANL has a very successful waste minimization program. Routine hazardous waste generation has been reduced over 90% since 1993. LANL has a DOE Order 450.1-compliant environmental management system (EMS) that is ISO 14001 certified; waste minimization is integral to setting annual EMS improvement objectives. Looking forward, under the new LANL management and operating contractor, Los Alamos National Security (LANS) LLC, a Zero Liquid Discharge initiative is being planned that should eliminate flow to the RLWTF NPDES-permitted outfall. The new contractor is also taking action to reduce the number of permitted waste storage areas, to charge generating programs directly for the cost to disposition waste, and to simplify/streamline the waste system. (authors)

  15. Clearing the air in Los Angeles

    SciTech Connect

    Lents, J.M.; Kelly, W.J.

    1993-10-01

    Los Angeles is one of the few places in the nation where air quality has improved dramatically since the 1970s. From 1955 to 1992 the peak level of ozone - one of the best indicators of air pollution - declined from 680 parts per billion to 300 parts per billion. The California Air Resources Board recently documented the population exposure the unhealthful ozone levels has been cut in half in just the past decade. Furthermore, the smog levels measured during each of the past three years have been the lowest on record. During the past 40 years, the citizens of Los Angeles have been very active in the fight for clean air, but from time to time they have neglected the issue because they feared that air-quality regulations were incompatible with the region`s economic interests. The AQMD and its sibling agencies plan to attack the pollution problem in three stages. The first stage, dubbed Tier I, includes 135 measures that can be accomplished using existing technologies and are to be adopted by 1996. The second stage, or Tier II, will take the region into the 21st century. These measures rely on technologies that have just entered the commercial market. The third stage, Tier III, requires technologies that have not been fully developed but are likely to be available in the next decade or so. 4 refs.

  16. LAMPF II workshop, Los Alamos National Laboratory, Los Alamos, New Mexico, February 1-4, 1982

    SciTech Connect

    Thiessen, H.A.

    1982-01-01

    This report contains the proceedings of the first LAMPF II Workshop held at Los Alamos February 1 to 4, 1982. Included are the talks that were available in written form. The conclusion of the participants was that there are many exciting areas of physics that will be addressed by such a machine.

  17. Los Dias de Los Muertos. The Days of the Dead. 1991 Edition.

    ERIC Educational Resources Information Center

    Lane, Sarah; Turkovich, Marilyn

    The Dias de los Muertos is a celebration of Mexico that is a recognition of mortality, transience, and death, and a celebration of life, hope, and resurrection. This curriculum activity book begins with a general introduction to the festival followed by sections of explanations and activities intended to engage the learner in various aspects of…

  18. Biological assessment for the effluent reduction program, Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect

    Cross, S.P.

    1996-08-01

    This report describes the biological assessment for the effluent recution program proposed to occur within the boundaries of Los Alamos National Laboratory. Potential effects on wetland plants and on threatened and endangered species are discussed, along with a detailed description of the individual outfalls resulting from the effluent reduction program.

  19. "Los Ninos y los Libros": Noteworthy Books in Spanish for the Very Young.

    ERIC Educational Resources Information Center

    Schon, Isabel

    2001-01-01

    Reviews 15 children's books in Spanish. Titles reviewed include: "Perro y gato [Dog and Cat]" (Ricardo Alcantara); "Baldomero va a la escuela [Baldomero goes to School]" (Alain Broutin); "Duerme bien, pequeno oso [Sleep well, Little Bear]" (Quint Buchholz); "El mas bonito de todos los regales del mundo [The Most Beautiful Gift in the World]…

  20. "Los Ninos y los Libros": Noteworthy Books in Spanish for the Very Young.

    ERIC Educational Resources Information Center

    Schon, Isabel

    2001-01-01

    Reviews 15 children's books in Spanish. Titles reviewed include: "Perro y gato [Dog and Cat]" (Ricardo Alcantara); "Baldomero va a la escuela [Baldomero goes to School]" (Alain Broutin); "Duerme bien, pequeno oso [Sleep well, Little Bear]" (Quint Buchholz); "El mas bonito de todos los regales del mundo [The Most Beautiful Gift in the World]…

  1. Portable MRI developed at Los Alamos

    ScienceCinema

    Espy, Michelle

    2016-07-12

    Scientists at Los Alamos National Laboratory are developing an ultra-low-field Magnetic Resonance Imaging (MRI) system that could be low-power and lightweight enough for forward deployment on the battlefield and to field hospitals in the World's poorest regions. "MRI technology is a powerful medical diagnostic tool," said Michelle Espy, the Battlefield MRI (bMRI) project leader, "ideally suited for imaging soft-tissue injury, particularly to the brain." But hospital-based MRI devices are big and expensive, and require considerable infrastructure, such as large quantities of cryogens like liquid nitrogen and helium, and they typically use a large amount of energy. "Standard MRI machines just can't go everywhere," said Espy. "Soldiers wounded in battle usually have to be flown to a large hospital and people in emerging nations just don't have access to MRI at all. We've been in contact with doctors who routinely work in the Third World and report that MRI would be extremely valuable in treating pediatric encephalopathy, and other serious diseases in children." So the Los Alamos team started thinking about a way to make an MRI device that could be relatively easy to transport, set up, and use in an unconventional setting. Conventional MRI machines use very large magnetic fields that align the protons in water molecules to then create magnetic resonance signals, which are detected by the machine and turned into images. The large magnetic fields create exceptionally detailed images, but they are difficult and expensive to make. Espy and her team wanted to see if images of sufficient quality could be made with ultra-low-magnetic fields, similar in strength to the Earth's magnetic field. To achieve images at such low fields they use exquisitely sensitive detectors called Superconducting Quantum Interference Devices, or SQUIDs. SQUIDs are among the most sensitive magnetic field detectors available, so interference with the signal is the primary stumbling block. "SQUIDs are

  2. Portable MRI developed at Los Alamos

    SciTech Connect

    Espy, Michelle

    2015-04-22

    Scientists at Los Alamos National Laboratory are developing an ultra-low-field Magnetic Resonance Imaging (MRI) system that could be low-power and lightweight enough for forward deployment on the battlefield and to field hospitals in the World's poorest regions. "MRI technology is a powerful medical diagnostic tool," said Michelle Espy, the Battlefield MRI (bMRI) project leader, "ideally suited for imaging soft-tissue injury, particularly to the brain." But hospital-based MRI devices are big and expensive, and require considerable infrastructure, such as large quantities of cryogens like liquid nitrogen and helium, and they typically use a large amount of energy. "Standard MRI machines just can't go everywhere," said Espy. "Soldiers wounded in battle usually have to be flown to a large hospital and people in emerging nations just don't have access to MRI at all. We've been in contact with doctors who routinely work in the Third World and report that MRI would be extremely valuable in treating pediatric encephalopathy, and other serious diseases in children." So the Los Alamos team started thinking about a way to make an MRI device that could be relatively easy to transport, set up, and use in an unconventional setting. Conventional MRI machines use very large magnetic fields that align the protons in water molecules to then create magnetic resonance signals, which are detected by the machine and turned into images. The large magnetic fields create exceptionally detailed images, but they are difficult and expensive to make. Espy and her team wanted to see if images of sufficient quality could be made with ultra-low-magnetic fields, similar in strength to the Earth's magnetic field. To achieve images at such low fields they use exquisitely sensitive detectors called Superconducting Quantum Interference Devices, or SQUIDs. SQUIDs are among the most sensitive magnetic field detectors available, so interference with the signal is the primary stumbling block. "SQUIDs are

  3. Los Alamos controlled-air incineration studies

    SciTech Connect

    Koenig, R.A.; Warner, C.L.

    1983-01-01

    Current regulations of the Environmental Protection Agency (EPA) require that PCBs in concentrations greater than 500 ppM be disposed of in EPA-permitted incinerators. Four commercial incineration systems in the United States have EPA operating permits for receiving and disposing of concentrated PCBs, but none can accept PCBs contaminated with nuclear materials. The first section of this report presents an overview of an EPA-sponsored program for studying PCB destruction in the large-scale Los Alamos controlled-air incinerator. A second major FY 1983 program, sponsored by the Naval Weapons Support Center, Crane, Indiana, is designed to determine operating conditions that will destroy marker smoke compounds without also forming polycyclic aromatic hydrocarbons (PAHs), some of which are known or suspected to be carcinogenic. We discuss the results of preliminary trial burns in which various equipment and feed formulations were tested. We present qualitative analyses for PAHs in the incinerator offgas as a result of these tests.

  4. Environmental surveillance at Los Alamos during 1992

    SciTech Connect

    Kohen, K.; Stoker, A.; Stone, G.

    1994-07-01

    This report describes the environmental surveillance program at Los Alamos National Laboratory during 1992. The Laboratory routinely monitors for radiation and for radioactive and nonradioactive materials at (or on) Laboratory sites as well as in the surrounding region. LANL uses the monitoring results to determine compliance with appropriate standards and to identify potentially undesirable trends. Data were collected in 1992 to assess external penetrating radiation; quantities of airborne emissions and liquid effluents; concentrations of chemicals and radionuclides in ambient air, surface waters and groundwaters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Using comparisons with standards, regulations, and background levels, this report concludes that environmental effects from Laboratory operations are small and do not pose a demonstrable threat to the public, laboratory employees, or the environment.

  5. Foreign National Involvement at Los Alamos

    NASA Astrophysics Data System (ADS)

    Wilhelmy, Jerry

    2000-04-01

    Since the beginning of the spring of 1999 there has been an intense national media focus on alleged security breaches by a foreign born scientist employed at LANL. Alarmed by an apparent growing sense of xenophobia, the Fellows of the Los Alamos National Laboratory addressed this issue by preparing a white paper on Foreign National Involvement at LANL (www.fellows.lanl.gov). Its purpose was to recognize and acknowledge the vital role that foreign scientists have played and continue to play in making LANL a forefront scientific institution. This legacy will be discussed, as well as concerns that constraining regulations triggered by this episode and subsequent reactions to this by our scientific peer community could have long term consequences on the vitality of the Laboratory.

  6. Information about Practicums at Los Alamos

    SciTech Connect

    Bradley, Paul A.

    2012-07-24

    The Los Alamos Neutron Science Center is the premier facility for neutron science experiments ranging from cross section measurements, neutron scattering experiments, proton radiography, cold neutrons, actinide neutronic properties, and many other exciting topics. The National High Magnetic Field Laboratory is home to several powerful magnets, including the one that created the first non-destructive 100 Tesla field in March 2012. They probe the electronic structure of superconductors, magnetic properties of materials (including magneto-quantum effects). Research is also conducted in correlated materials, thermoacoustics, and magnetic properties of actinides. The Trident Laser has a unique niche with very high power, short pulse experiments, with a peak power of 10{sup 20} W in short pulse mode. Discoveries range from production of monoenergetic MeV ion beam, nonlinear kinetic plasma waves, the transition between kinetic and fluid nonlinear behavior and other laser-plasma interaction processes.

  7. Los Angeles - Long Beach Harbors, CA

    NASA Image and Video Library

    2015-03-16

    In southern California, the combined ports of Los Angeles and Long Beach account for 33% of the nation containerized imports. This image from NASA Terra spacecraft shows the large backlog of waiting cargo ships being slowly unloaded. The left image was acquired July 4, 2014 during normal operations: 14 ships are being unloaded, while 7 wait their turns near the facilities. The right image was acquired on March 8, 2015: 19 ships are moored at unloading docks, while 47 ships wait their turns. The images cover an area of 16.7 x 18.6 km, and are located at 33.7 degrees north, 118.2 degrees west. http://photojournal.jpl.nasa.gov/catalog/PIA19249

  8. Environmental surveillance at Los Alamos during 1979

    SciTech Connect

    Not Available

    1980-04-01

    This report documents the environmental surveillance program conducted by the Los Alamos Scientific Laboratory (LASL) in 1979. Routine monitoring for radiation and radioactive or chemical substances was conducted on the Laboratory site and in the surrounding region to determine compliance with appropriate standards and permit early identification of possible undesirable trends. Results and interpretation of the data for 1979 on penetrating radiation, chemical and radiochemical quality of ambient air, surface and ground water, municipal water supply, soils and sediments, food, and airborne and liquid effluents are included. Comparisons with appropriate standards and regulations or with background levels from natural or other non-LASL sources provide a basis for concluding that environmental effects attributable to LASL operations are minor and cannot be considered likely to result in any hazard to the population of the area. Results of several special studies provide documentation of some unique environmental conditions in the LASL environs.

  9. Environmental surveillance at Los Alamos during 1995

    SciTech Connect

    1996-10-01

    This report describes the environmental surveillance program at Los Alamos National Laboratory (LANL or the Laboratory) during 1995. The Laboratory routinely monitors for radiation and for radioactive and nonradioactive materials at (or on) Laboratory sites as well as in the surrounding region. LANL uses the monitoring result to determine compliance with appropriate standards and to identify potentially undesirable trends. Data were collected in 1995 to assess external penetrating radiation; quantities of airborne emissions and liquid effluents; concentrations of chemicals and radionuclides in ambient air, surface waters and groundwaters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Using comparisons with standards, regulations, and background levels, this report concludes that environmental effects from Laboratory operations are small and do not pose a demonstrable threat to the public, Laboratory employees, or the environment.

  10. Update on the Los Alamos UCN Source

    NASA Astrophysics Data System (ADS)

    Makela, Mark

    2014-03-01

    The ultracold neutron (UCN) source at Los Alamos National Lab has been running since 2005. During this time the source production has steadily increased due to upgrades. The source feeds two experimental beam lines. The primary beam line feeds the UCNA spectrometer and the other feeds the UCN lifetime experiment and various small scale experiments. The source produces UCN from spallation neutrons by first moderating them to cold temperatures with cold polyethylene and five Kelvin deuterium; these cold neutrons then knock off a phonon in the cold deuterium and become UCN (this final step is not an equilibrium process). In preparation for upgrading the beam delivery system to the spallation target several studies have been done to determine the best beam pattern to derive the maximum UCN density in experiments. The results of these studies and the predicted increase in ucn density will be presented. In addition to these studies a new ucn source design will be presented.

  11. Recent development in pyrochemistry at Los Alamos

    SciTech Connect

    McNeese, J.A.; Fife, K.W.; Williams, J.D.

    1984-01-01

    Recent developments in pyrochemical processing at Los Alamos include the recovery of plutonium from anodes and impure metal by pyroredox and new molten salt handling and purification techniques. The anode is dissolved in a ZnCl/sub 2/ KCl salt to form PuCl/sub 3/ and a zinc and impurities button. Calcium reduction of the PuCl/sub 3/ yields 95 to 98% pure plutonium. New techniques for transferring molten salt from a purification or regeneration vessel to molds has been successfully developed and demonstrated. Additional salt work involving recycle of direct oxide reduction salts using anhydrous hydrogen chloride, phosgene, and chlorine gases is under way. 13 figures, 1 table.

  12. Los Alamos Advanced Free-Electron Laser

    SciTech Connect

    Chan, K.C.D.; Kraus, R.H.; Ledford, J.; Meier, K.L.; Meyer, R.E.; Nguyen, D.; Sheffield, R.L.; Sigler, F.L.; Young, L.M.; Wang, T.S.; Wilson, W.L.; Wood, R.L.

    1991-01-01

    At Los Alamos, we are building a free-electron laser (FEL) for industrial, medical, and research applications. This FEL, which will incorporate many of the new technologies developed over the last decade, will be compact in size, robust, and user-friendly. Electrons produced by a photocathode will be accelerated to 20 MeV by a high-brightness accelerator and transported using permanent-magnet quadrupoles and dipoles. They will form an electron beam with an excellent instantaneous beam quality of 10 {pi} mm mrad in transverse emittance and 0.3% in energy spread at a peak current up to 300 A. Including operation at higher harmonics, the laser wavelength extends form 3.7 {mu}m to 0.4 {mu}m. In this paper, we will describe the project and the programs to date. 10 refs., 10 figs., 1 tab.

  13. Los Alamos National Laboratory transuranic database analysis

    SciTech Connect

    Christensen, D.V.; Rogers, P.S.Z.; Kosiewicz, S.T.; LeBrun, D.B.

    1997-02-01

    This paper represents an overview of analyses conducted on the TRU database maintained by the Los Alamos National Laboratory (LANL). This evaluation was conducted to support the ``TRU Waste Workoff Strategies`` document and provides an estimation of the waste volume that potentially could be certified and ready for shipment to (WIPP) in April of 1998. Criteria defined in the WIPP WAC, including container type, weight limits, plutonium fissile gram equivalents and decay heat, were used to evaluated the waste for compliance. LANL evaluated the containers by facility and by waste stream to determining the most efficient plan for characterization and certification of the waste. Evaluation of the waste presently in storage suggested that 40- 60% potentially meets the WIPP WAC Rev. 5 criteria.

  14. Environmental surveillance at Los Alamos during 1987

    SciTech Connect

    Not Available

    1988-05-01

    This report describes the environmental surveillance program conducted by Los Alamos National Laboratory during 1987. Routine monitoring for radiation and radioactive or chemical materials is conducted on the Laboratory site as well as in the surrounding region. Monitoring results are used to determine compliance with appropriate standards and to permit early identification of potentially undesirable trends. Results and interpretation of data for 1987 cover: external penetrating radiation; quantities of airborne emissions and liquid effluents; concentrations of chemicals and radionuclides in ambient air, surface and ground waters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Comparisons with appropriate standards, regulations, and background levels provide the basis for concluding that environmental effects from Laboratory operations are insignificant and do not pose a threat to the public, Laboratory employees, or the environment. 113 refs., 33 figs., 120 tabs.

  15. Environmental surveillance at Los Alamos during 1989

    SciTech Connect

    Not Available

    1990-12-01

    This report describes the environmental surveillance program conducted by Los Alamos National Laboratory during 1989. Routine monitoring for radiation and radioactive or chemical materials is conducted on the Laboratory site as well as in the surrounding region. Monitoring results are used to determine compliance with appropriate standards and to permit early identification of potentially undesirable trends. Results and interpretation of data for 1989 cover external penetrating radiation; quantities of airborne emissions and effluents; concentrations of chemicals and radionuclides in ambient air, surface and ground waters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Comparisons with appropriate standards, regulations, and background levels provide the basis for concluding that environmental effects from Laboratory operations are small and do not pose a threat to the public, Laboratory employees, or the environment. 58 refs., 31 figs., 39 tabs.

  16. Environmental surveillance at Los Alamos during 2008

    SciTech Connect

    Fuehne, David; Gallagher, Pat; Hjeresen, Denny; Isaacson, John; Johson, Scot; Morgan, Terry; Paulson, David; Rogers, David

    2009-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (the Laboratory) Environmental Programs Directorate, as required by US Department of Energy Order 450.1, General Environmental Protection Program, and US Department of Energy Order 231.1A, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory’s efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory’s major environmental programs and explains the risks and the actions taken to reduce risks at the Laboratory from environmental legacies and waste management operations. Chapter 2 reports the Laboratory’s compliance status for 2007. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations and discusses chemical exposures. The environmental surveillance and monitoring data are organized by environmental media (Chapter 4, air; Chapters 5 and 6, water and sediments; Chapter 7, soils; and Chapter 8, foodstuffs and biota) in a format to meet the needs of a general and scientific audience. Chapter 9 provides a summary of the status of environmental restoration work around LANL. A glossary and a list of acronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the Laboratory’s technical areas and their associated programs, and Appendix D provides web links to more information.

  17. Environmental surveillance at Los Alamos during 2005

    SciTech Connect

    2006-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (LANL or the Laboratory) environmental organization, as required by US Department of Energy Order 5400.1, General Environmental Protection Program, and US Department of Energy Order 231.IA, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory's efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory's major environmental programs. Chapter 2 reports the Laboratory's compliance status for 2005. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations. The environmental surveillance and monitoring data are organized by environmental media (Chapter 4, Air; Chapters 5 and 6, Water and Sediments; Chapter 7, Soils; and Chapter 8, Foodstuffs and Biota) in a format to meet the needs of a general and scientific audience. Chapter 9, new for this year, provides a summary of the status of environmental restoration work around LANL. A glossary and a list ofacronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the Laboratory's technical areas and their associated programs, and Appendix D provides web links to more information.

  18. Environmental surveillance at Los Alamos during 2009

    SciTech Connect

    Fuehne, David; Poff, Ben; Hjeresen, Denny; Isaacson, John; Johnson, Scot; Morgan, Terry; Paulson, David; Salzman, Sonja; Rogers, David

    2010-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (the Laboratory) environmental organization, as required by US Department of Energy Order 5400.1, General Environmental Protection Program, and US Department of Energy Order 231.1A, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory’s efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory’s major environmental programs and explains the risks and the actions taken to reduce risks at the Laboratory from environmental legacies and waste management operations. Chapter 2 reports the Laboratory’s compliance status for 2009. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations and discusses chemical exposures. The environmental surveillance and monitoring data are organized by environmental media (air in Chapter 4; water and sediments in Chapters 5 and 6; soils in Chapter 7; and foodstuffs and biota in Chapter 8) in a format to meet the needs of a general and scientific audience. Chapter 9 provides a summary of the status of environmental restoration work around LANL. The new Chapter 10 describes the Laboratory’s environmental stewardship efforts and provides an overview of the health of the Rio Grande. A glossary and a list of acronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the Laboratory’s technical

  19. Meningococcal group A lipooligosaccharides (LOS): preliminary structural studies and characterization of serotype-associated and conserved LOS epitopes.

    PubMed Central

    Kim, J J; Phillips, N J; Gibson, B W; Griffiss, J M; Yamasaki, R

    1994-01-01

    Structural studies indicate that the neisserial lipooligosaccharides (LOS) are composed of an oligosaccharide (OS) portion with a phosphorylated diheptose (Hep) core attached to the toxic lipid A moiety. A conserved meningococcal LOS epitope, defined by monoclonal antibody (MAb) D6A, is expressed on group A and many group B and C meningococci of different LOS serotypes (J. J. Kim, R. E. Mandrell, H. Zhen, M. A. Apicella, J. T. Poolman, and J. M. Griffiss, Infect. Immun. 56:2631-2638, 1988). This MAb-defined D6A epitope is immunogenic in humans (M. M. Estabrook, R. E. Mandrell, M. A. Apicella, and J. M. Griffiss, Infect. Immun. 58:2204-2213, 1990; M. M. Estabrook, C. J. Baker, and J. M. Griffiss, J. Infect. Dis. 197:966-970, 1993). In this study, we characterize this important MAb-defined LOS epitope. Serotype L10 and L11 group A meningococal LOS were chemically modified and used to investigate what portion of the LOS molecule is important for expression of the conserved (D6A) epitope and serotype-associated LOS epitopes by use of immunoblotting techniques and selected MAbs as probes. Preliminary structural characterization of the LOS was also accomplished by electrospray ionization-mass spectrometry. Our results indicate the following. (i) Antibodies that recognize the serotype-associated or conserved LOS epitopes recognize the OS portion of the LOS. (ii) The phosphorylated diheptose core region of the OS is essential for expression of the conserved D6A epitope. (iii) The lipid portion of the molecule is important for optimum expression of the LOS epitopes. (iv) The proposed compositions of the O-deacylated LOS are consistent with the presence of a phosphorylated diheptose core and are as follows: for O-deacylated L10 LOS, 3Hex (hexose), 1HexNAc (N-acetylhexosamine), 2KDO (2-keto-3-deoxy-D-manno-octulosonic acid), 2Hep (heptose), 1PEA or 2PEA (phosphoethanolamine), and O-deacylated lipid A; and for O-deacylated L11 LOS, 2Hex, 1HexNAc, 2KDO, 2Hep, 2PEA, and O

  20. Conversation with Lara about the Earth and Land. (Spanish Title: Conversando con Lara sobre la Tierra y la Teirra.) Conversando com Lara sobre a Terra e a Terra

    NASA Astrophysics Data System (ADS)

    da Conceição Barbosa-Lima, Maria

    2010-12-01

    en que vive es el planeta Tierra y que, probablemente por ese motivo, distingue con precisión, dentro de los limites de comprensión de la edad y madurez asociada, la tierra y la Tierra. O presente artigo analisa uma entrevista livre enquanto uma menina de quatro anos e quatro meses, matriculada na educação infantil, desenhava a Terra. A entrevista se realizou fora do ambiente escolar e sem qualquer outra pessoa por perto que pudesse interferir. De acordo com Ferreira & Silva (2004), para que o pesquisador conheça realmente o que uma criança põe no papel através de grafismos e/ou desenhos, é necessário ouvi-la durante o processo de criação do desenho. A menina apresenta, em relação à Terra, o tradicional desenho plano com o 'céu' paralelo ao solo, conforme já apresentaram Nardi & Carvalho (1996). Mas quando solicitada a desenhar o Mundo - palavra empregada em um trabalho por Butterworth et al. (2002), com intenção de não provocar 'confusões' desnecessárias para seus pesquisados - o representa de forma circular, colocando-se sobre sua superfície. Seus desenhos levaram à conclusão que esta criança ainda não tem conhecimento de que o Mundo em que vive é o Planeta Terra e que, provavelmente por este motivo, diferencia com precisão, dentro dos limites impostos por sua idade e consequente maturidade, a terra e a Terra.

  1. The LACDA (Los Angeles County Drainage Area) System Recreation Study, Los Angeles County Drainage Area.

    DTIC Science & Technology

    1980-03-01

    the Nation dt, t:... .. .Los Angeles District in association with DANIEL, MANN, JOHNSON, & MENDENHALL URBAN DESIGN DISCIPLINES, INC. 3250 WILSHIRE...POTENTIAL TRAIL PROJECTS 4-3 Planning and Design of Trail Projects 4-3 Classification of Potential Trail Projects 4-3 Bicycle Trails 4-6 Equestrian...bicycles for both recreation routes and the design of trail facilities: arid commuting and would be a major stimulus to equestrian activity in the area

  2. Environmental analysis of Lower Pueblo/Lower Los Alamos Canyon, Los Alamos, New Mexico

    SciTech Connect

    Ferenbaugh, R.W.; Buhl, T.E.; Stoker, A.K.; Becker, N.M.; Rodgers, J.C.; Hansen, W.R.

    1994-12-01

    The radiological survey of the former radioactive waste treatment plant site (TA-45), Acid Canyon, Pueblo Canyon, and Los Alamos Canyon found residual contamination at the site itself and in the channel and banks of Acid, Pueblo, and lower Los Alamos Canyons all the way to the Rio Grande. The largest reservoir of residual radioactivity is in lower Pueblo Canyon, which is on DOE property. However, residual radioactivity does not exceed proposed cleanup criteria in either lower Pueblo or lower Los Alamos Canyons. The three alternatives proposed are (1) to take no action, (2) to construct a sediment trap in lower Pueblo Canyon to prevent further transport of residual radioactivity onto San Ildefonso Indian Pueblo land, and (3) to clean the residual radioactivity from the canyon system. Alternative 2, to cleanup the canyon system, is rejected as a viable alternative. Thousands of truckloads of sediment would have to be removed and disposed of, and this effort is unwarranted by the low levels of contamination present. Residual radioactivity levels, under either present conditions or projected future conditions, will not result in significant radiation doses to persons exposed. Modeling efforts show that future transport activity will not result in any residual radioactivity concentrations higher than those already existing. Thus, although construction of a sediment trap in lower Pueblo Canyon is a viable alternative, this effort also is unwarranted, and the no-action alternative is the preferred alternative.

  3. Environmental Surveillance at Los Alamos during 2007

    SciTech Connect

    2008-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (the Laboratory) Environmental Directorate, as required by US Department of Energy Order 450.1, General Environmental Protection Program, and US Department of Energy Order 231.1A, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory’s efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory’s major environmental programs and explains the risks and the actions taken to reduce risks at the Laboratory from environmental legacies and waste management operations. Chapter 2 reports the Laboratory’s compliance status for 2007. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations and discusses chemical exposures. The environmental surveillance and monitoring data are organized by environmental media (Chapter 4, air; Chapters 5 and 6, water and sediments; Chapter 7, soils; and Chapter 8, foodstuffs and biota) in a format to meet the needs of a general and scientific audience. Chapter 9 provides a summary of the status of environmental restoration work around LANL. A glossary and a list of acronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the laboratory’s technical areas and their associated programs, and Appendix D provides web links to more information. In printed copies of this report or Executive Summary, we have

  4. Studies of the Los Angeles aerosol:

    NASA Astrophysics Data System (ADS)

    Xiong, Cheng

    This work addresses two important but little studied aspects of the behavior of the atmospheric aerosol: (1)the contributions of the atmospheric aerosol to the surface microlayer (SMIC) of natural waters (a biochemically sensitive site) and (2)the morphological properties of atmospheric aerosols. The first part of the study involved a cooperative program for concurrent measurements of atmospheric aerosol, SMIC, and water column samples. Our group measured aerosol chemical characteristics (in terms of total concentrations and size distributions of various elements) at several locations on the west side of Los Angeles including above Santa Monica Bay. Scatter diagrams were made of SMIC concentrations for various elements vs. atmospheric aerosol concentrations of the same elements for similar time periods. The scatter diagrams identified a subset of elements in the SMIC that tended to increase with the atmospheric concentrations of the same elements. For these elements atmospheric deposition is probably a major source in the SMIC. Our scatter diagrams offer a novel approach to source resolution for the SMIC and potentially, a new method of determining dry deposition rates to natural waters. The second part of the research describes the first systematic study of the morphological properties of atmospheric aggregates in the ultrafine particle size range (dp <= 0.1 μm). These aggregates are emitted from diesel engines and other high temperature sources and have been linked to adverse effects on public health. Particles were collected from the atmospheric air on transmission electron microscope (TEM) grids fitted on the last two stages of a single- jet, eight-stage, low pressure impactor (LPI). Photomicrographs of the TEM grids were analyzed to obtain the fractal dimension (D f) and prefactor (A) for aggregates. Values of Df increased from near 1 to above 2 as the number of primary particles making up the aggregates increased from 10 to 180 for the measurements made in

  5. Coca-Cola Hispanic Education Fund: Los Angeles Program Description.

    ERIC Educational Resources Information Center

    Coca Cola Bottling Co. of Los Angeles, CA.

    The Coca-Cola Hispanic Education Fund was created in response to the high school dropout problem in Los Angeles. The Fund enables the Coca-Cola Bottling Company of Los Angeles to build upon the successful relationship it has developed in the Hispanic community and maximizes the effectiveness of existing student support programs by directing needy…

  6. Los Angeles Tries Luring Back Dropouts via Social Networks

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2007-01-01

    This article reports that education leaders in Los Angeles, faced with unrelenting pressure to raise anemic high school graduation rates, are turning to YouTube, MySpace, text messaging, and the radio waves to reach students at risk of dropping out of school and lure back thousands who have already left. The Los Angeles Unified School…

  7. Glitches in Los Angeles Payroll System Spark Furor

    ERIC Educational Resources Information Center

    Trotter, Andrew

    2007-01-01

    Thousands of Los Angeles teachers have not been paid properly for months because of errors in a corporate-style payroll system that was introduced in January as part of a sweeping, $95 million computer modernization. The Los Angeles Unified School District acknowledges that the payroll system's rollout was rushed and tainted by numerous…

  8. Korean Language Maintenance in Los Angeles. Professional Papers K-1.

    ERIC Educational Resources Information Center

    Kim, Kenneth Kong-On; And Others

    Characteristics of the Korean population in Los Angeles, intergenerational cultural problems, and efforts to promote language maintenance are described. The majority of Koreans in Los Angeles have been in the United States less than 10 years. A high percentage are from middle class and professional backgrounds. The traditional hierarchical family…

  9. Dialect Contact among Spanish-Speaking Children in Los Angeles

    ERIC Educational Resources Information Center

    Villarreal, Belen MacGregor

    2014-01-01

    As an immigration hub for a diverse group of Spanish speakers, Los Angeles lends itself to research on dialect contact and leveling. Studies regarding the Spanish spoken by natives of Los Angeles reveal considerable homogeneity with respect to pronunciation, vocabulary and terms of address. This uniformity is notable because two different dialect…

  10. Glitches in Los Angeles Payroll System Spark Furor

    ERIC Educational Resources Information Center

    Trotter, Andrew

    2007-01-01

    Thousands of Los Angeles teachers have not been paid properly for months because of errors in a corporate-style payroll system that was introduced in January as part of a sweeping, $95 million computer modernization. The Los Angeles Unified School District acknowledges that the payroll system's rollout was rushed and tainted by numerous…

  11. Audit of personal property management at Los Alamos National Laboratory

    SciTech Connect

    Not Available

    1993-12-07

    The Department of Energy`s (Department) Albuquerque Operations Office (Albuquerque) and the Los Alamos National Laboratory (Los Alamos) are responsible for ensuring that Los Alamos maintains an efficient and effective personal property management system that protects, identifies, and controls Government-owned personal property in accordance with applicable regulations. Albuquerque is responsible for reviewing and approving Los Alamos` personal property management system. Los Alamos is responsible for ensuring that personal property is properly protected, identified, and controlled. The audit disclosed that Los Alamos did not have an efficient and effective personal property management system to ensure that personal property was adequately protected, identified, and controlled. In addition, Albuquerque did not approve or disapprove Los Alamos` personal property management system consistent with Federal and Department regulations. Specifically, the audit showed that Los Alamos did not account for $11.6 million of personal property. In addition, $22.2 million of personal property was not properly recorded in the database, $61.7 million of personal property could not be inventoried, and loans to employees and other entities were not adequately justified. As a result, from a total personal property inventory of approximately $1 billion, it is estimated that $100 million of personal property may not be accounted for, and $207 million may not be correctly recorded in the database. Moreover, substantial amounts of personal property on loan to employees and other entities were at risk of unauthorized use. Albuquerque concurred with the finding and agreed to implement the corrective actions recommended in the report.

  12. Battle in Los Angeles: Conflict Escalates as Charter Schools Thrive

    ERIC Educational Resources Information Center

    Whitmire, Richard

    2016-01-01

    Throughout the 1990s and well into the new millennium, the massive Los Angeles Unified School District barely noticed the many charter schools that were springing up around the metropolis. But Los Angeles parents certainly took notice, and started enrolling their children. In 2008, five charter-management organizations announced plans to…

  13. Dialect Contact among Spanish-Speaking Children in Los Angeles

    ERIC Educational Resources Information Center

    Villarreal, Belen MacGregor

    2014-01-01

    As an immigration hub for a diverse group of Spanish speakers, Los Angeles lends itself to research on dialect contact and leveling. Studies regarding the Spanish spoken by natives of Los Angeles reveal considerable homogeneity with respect to pronunciation, vocabulary and terms of address. This uniformity is notable because two different dialect…

  14. Los LGBT y fumar | Smokefree Español

    Cancer.gov

    En Estados Unidos, las personas lesbianas, gays, bisexuales y transexuales (LGBT) tienen el doble de probabilidades de empezar a fumar que los heterosexuales. Sepa por qué los miembros de la comunidad LGBT fuman y aprenda estrategias para dejar de fumar definitivamente.

  15. Los Alamos personnel and area criticality dosimeter systems

    SciTech Connect

    Vasilik, D.G.; Martin, R.W.

    1981-06-01

    Fissionable materials are handled and processed at the Los Alamos National Laboratory. Although the probability of a nuclear criticality accident is very remote, it must be considered. Los Alamos maintains a broad spectrum of dose assessment capabilities. This report describes the methods employed for personnel neutron, area neutron, and photon dose evaluations with passive dosimetry systems.

  16. Envisioning a Public Research Agenda in Los Angeles

    ERIC Educational Resources Information Center

    Vogelgesang, Lori J.; Gilliam, Franklin D., Jr.; O'Byrne, Kathy; Leal-Sotelo, Margaret

    2006-01-01

    The University of California, Los Angeles is an institution founded on a public mission and positioned as a world-renowned research university. This article describes the successes, challenges and future directions of a concerted institutional effort to engage with the broader Los Angeles community to address pressing social issues and needs. The…

  17. Coca-Cola Hispanic Education Fund: Los Angeles Program Description.

    ERIC Educational Resources Information Center

    Coca Cola Bottling Co. of Los Angeles, CA.

    The Coca-Cola Hispanic Education Fund was created in response to the high school dropout problem in Los Angeles. The Fund enables the Coca-Cola Bottling Company of Los Angeles to build upon the successful relationship it has developed in the Hispanic community and maximizes the effectiveness of existing student support programs by directing needy…

  18. The Climate at Los Alamos; Are we measurement changes?

    SciTech Connect

    Dewart, Jean Marie

    2015-04-16

    A new report shows new graphic displays of the weather trends in Los Alamos, New Mexico, and at the Los Alamos National Laboratory (LANL). The graphs show trends of average, minimum average, and maximum average temperature for summer and winter months going back decades. Records of summer and winter precipitation are also included in the report.

  19. Los Angeles Tries Luring Back Dropouts via Social Networks

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2007-01-01

    This article reports that education leaders in Los Angeles, faced with unrelenting pressure to raise anemic high school graduation rates, are turning to YouTube, MySpace, text messaging, and the radio waves to reach students at risk of dropping out of school and lure back thousands who have already left. The Los Angeles Unified School…

  20. Battle in Los Angeles: Conflict Escalates as Charter Schools Thrive

    ERIC Educational Resources Information Center

    Whitmire, Richard

    2016-01-01

    Throughout the 1990s and well into the new millennium, the massive Los Angeles Unified School District barely noticed the many charter schools that were springing up around the metropolis. But Los Angeles parents certainly took notice, and started enrolling their children. In 2008, five charter-management organizations announced plans to…

  1. Historic Manhattan Project Sites at Los Alamos

    SciTech Connect

    McGehee, Ellen

    2014-05-22

    The Manhattan Project laboratory constructed at Los Alamos, New Mexico, beginning in 1943, was intended from the start to be temporary and to go up with amazing speed. Because most of those WWII-era facilities were built with minimal materials and so quickly, much of the original infrastructure was torn down in the late '40s and early '50s and replaced by more permanent facilities. However, a few key facilities remained, and are being preserved and maintained for historic significance. Four such sites are visited briefly in this video, taking viewers to V-Site, the buildings where the first nuclear explosive device was pre-assembled in preparation for the Trinity Test in Southern New Mexico. Included is another WWII area, Gun Site. So named because it was the area where scientists and engineers tested the so-called "gun method" of assembling nuclear materials -- the fundamental design of the Little Boy weapon that was eventually dropped on Hiroshima. The video also goes to Pajarito Site, home of the "Slotin Building" and "Pond Cabin." The Slotin Building is the place where scientist Louis Slotin conducted a criticality experiment that went awry in early 1946, leading to his unfortunate death, and the Pond Cabin served the team of eminent scientist Emilio Segre who did early chemistry work on plutonium that ultimately led to the Fat Man weapon.

  2. Saving Water at Los Alamos National Laboratory

    ScienceCinema

    Erickson, Andy

    2016-07-12

    Los Alamos National Laboratory decreased its water usage by 26 percent in 2014, with about one-third of the reduction attributable to using reclaimed water to cool a supercomputing center. The Laboratory's goal during 2014 was to use only re-purposed water to support the mission at the Strategic Computing Complex. Using reclaimed water from the Sanitary Effluent Reclamation Facility, or SERF, substantially decreased water usage and supported the overall mission. SERF collects industrial wastewater and treats it for reuse. The reclamation facility contributed more than 27 million gallons of re-purposed water to the Laboratory's computing center, a secured supercomputing facility that supports the Laboratory’s national security mission and is one of the institution’s larger water users. In addition to the strategic water reuse program at SERF, the Laboratory reduced water use in 2014 by focusing conservation efforts on areas that use the most water, upgrading to water-conserving fixtures, and repairing leaks identified in a biennial survey.

  3. Los Alamos upgrade in metallographic capabilities

    SciTech Connect

    Ledbetter, J.M.; Dowler, K.E.; Cook, J.H.

    1985-01-01

    The Los Alamos Wing 9 Hot Cell Facility is in the process of upgrading their metallographic sample preparation and examination capability. The present capability to grind, polish and etch samples from reactor fuels and materials has been in operation for 18 years. Macro photography and alpha and beta-gamma autoradiography are an important part of this capability. Some of the fast breeder reactor experiments have contained sodium as a coolant. Therefore, the capability to distill sodium from some samples scheduled for microstructural examinations is a requirement. Since the reactor fuel samples are highly radioactive and contain plutonium, either as fabricated or as a result of breeding during reactor service, these samples must be handled in shielded hot cells containing alpha boxes to isolate the plutonium and hazardous fission products from personnel and the environment. The present equipment that was designed and built into those alpha boxes has functioned very well for the past 18 years. During that time the technicians have thought of ways to improve the equipment to do the work faster and safer. These ideas and ideas that have been developed during the design of new alpha boxes and new equipment for microstructural sample preparation have provided the concepts for the capability to perform the work faster and maintain the equipment in a safer manner.

  4. Historic Manhattan Project Sites at Los Alamos

    ScienceCinema

    McGehee, Ellen

    2016-07-12

    The Manhattan Project laboratory constructed at Los Alamos, New Mexico, beginning in 1943, was intended from the start to be temporary and to go up with amazing speed. Because most of those WWII-era facilities were built with minimal materials and so quickly, much of the original infrastructure was torn down in the late '40s and early '50s and replaced by more permanent facilities. However, a few key facilities remained, and are being preserved and maintained for historic significance. Four such sites are visited briefly in this video, taking viewers to V-Site, the buildings where the first nuclear explosive device was pre-assembled in preparation for the Trinity Test in Southern New Mexico. Included is another WWII area, Gun Site. So named because it was the area where scientists and engineers tested the so-called "gun method" of assembling nuclear materials -- the fundamental design of the Little Boy weapon that was eventually dropped on Hiroshima. The video also goes to Pajarito Site, home of the "Slotin Building" and "Pond Cabin." The Slotin Building is the place where scientist Louis Slotin conducted a criticality experiment that went awry in early 1946, leading to his unfortunate death, and the Pond Cabin served the team of eminent scientist Emilio Segre who did early chemistry work on plutonium that ultimately led to the Fat Man weapon.

  5. Epidemiology of pancreas cancer in Los Angeles

    SciTech Connect

    Mack, T.M.; Paganini-Hill, A.

    1981-03-15

    The characteristics of the 3614 Los Angeles County residents in whom cancer of the exocrine pancreas was diagnosed during the period 1972-1977 were compared with those of all county residents and patients in whom any cancer was diagnosed during the same period. Seventy-nine percent of the diagnoses had been pathologically verified. This disease still preferentially afflicts the old, the black, and men, although the differences in risk with factors other than age are modest. The disease is not evenly distributed by social class, or over time, although it is not clear that the observed differences reflect etiology. The distributions with respect to important categories of occupation and industry, religion, marital status, geography of residence, and birthplace were rather uniform. Although there is no obvious explanation for any of several unexpected minor inequities in the pattern of incidence, there is no compelling evidence to support any specific environmental cause. There is substantial evidence which is inconsistent with those environmental hypotheses that have been proposed previously.

  6. Expanded recycling at Los Alamos National Laboratory

    SciTech Connect

    Betschart, J.F.; Malinauskas, L.; Burns, M.

    1996-07-01

    The Pollution Prevention Program Office has increased recycling activities, reuse, and options to reduce the solid waste streams through streamlining efforts that applied best management practices. The program has prioritized efforts based on volume and economic considerations and has greatly increased Los Alamos National Laboratory`s (LANL`s) recycle volumes. The Pollution Prevention Program established and chairs a Solid Waste Management Solutions Group to specifically address and solve problems in nonradioactive, Resource Conservation and Recovery Act (RCRA), state-regulated, and sanitary and industrial waste streams (henceforth referred to as sanitary waste in this paper). By identifying materials with recycling potential, identifying best management practices and pathways to return materials for reuse, and introducing the concept and practice of {open_quotes}asset management,{open_quotes} the Group will divert much of the current waste stream from disposal. This Group is developing procedures, agreements, and contracts to stage, collect, sort, segregate, transport and process materials, and is also garnering support for the program through the involvement of upper management, facility managers, and generators.

  7. Saving Water at Los Alamos National Laboratory

    SciTech Connect

    Erickson, Andy

    2015-03-16

    Los Alamos National Laboratory decreased its water usage by 26 percent in 2014, with about one-third of the reduction attributable to using reclaimed water to cool a supercomputing center. The Laboratory's goal during 2014 was to use only re-purposed water to support the mission at the Strategic Computing Complex. Using reclaimed water from the Sanitary Effluent Reclamation Facility, or SERF, substantially decreased water usage and supported the overall mission. SERF collects industrial wastewater and treats it for reuse. The reclamation facility contributed more than 27 million gallons of re-purposed water to the Laboratory's computing center, a secured supercomputing facility that supports the Laboratory’s national security mission and is one of the institution’s larger water users. In addition to the strategic water reuse program at SERF, the Laboratory reduced water use in 2014 by focusing conservation efforts on areas that use the most water, upgrading to water-conserving fixtures, and repairing leaks identified in a biennial survey.

  8. Uso de los Datos de Biomonitoreo para Informar sobre la Evaluacion Infantil (American translation is: USING BIOMONITORING DATA TO INFORM EXPOSURE ASSESSMENT IN CHILDREN)

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. This extended abstract was translated in Spanish and published in Acta Toxicologica Argentina.

  9. Uso de los Datos de Biomonitoreo para Informar sobre la Evaluacion Infantil (American translation is: USING BIOMONITORING DATA TO INFORM EXPOSURE ASSESSMENT IN CHILDREN)

    EPA Science Inventory

    Discussing the challenges associated with estimating and interpreting toxicant exposures and health risks from biomonitoring data. This extended abstract was translated in Spanish and published in Acta Toxicologica Argentina.

  10. La investigacion sobre la calidad de los programas para ninos de hasta dos anos de edad (Research on Quality in Infant-Toddler Programs). ERIC Digest.

    ERIC Educational Resources Information Center

    Honig, Alice Sterling

    Concern about the quality of infant-toddler care programs has grown recently in response to two factors. The first is the need of employed parents for such care, and the second is research emphasizing the importance of brain development in the early years. This Spanish-language Digest introduces some of the many issues related to the quality of…

  11. Otra perspectiva sobre lo que los ninos deben estar aprendiendo (Another Look at What Young Children Should Be Learning). ERIC Digest.

    ERIC Educational Resources Information Center

    Katz, Lilian G.

    This Spanish-language ERIC Digest addresses the question of what young children should be learning that will best serve their development and learning in the long term. Two major dimensions of development--normative and dynamic--are explored, and four categories of learning goals are discussed: (1) knowledge; (2) skills; (3) dispositions; and (4)…

  12. Tax and Record Keeping Information for Family Child Care = Informacion Sobre los Impuestos y la Documentacion para el Cuidado Infantil en el Hogar.

    ERIC Educational Resources Information Center

    Gellert, Sandra

    This pamphlet from the Children's Foundation, in both English- and Spanish-language versions, provides advice to child care providers on record-keeping methods. The pamphlet also gives definitions and guidance on business expenses (100% deductible, shared personal and business, and depreciated capital expenses), time-space formula, self-employment…

  13. Tax and Record Keeping Information for Family Child Care = Informacion Sobre los Impuestos y la Documentacion para el Cuidado Infantil en el Hogar.

    ERIC Educational Resources Information Center

    Gellert, Sandra

    This pamphlet from the Children's Foundation, in both English- and Spanish-language versions, provides advice to child care providers on record-keeping methods. The pamphlet also gives definitions and guidance on business expenses (100% deductible, shared personal and business, and depreciated capital expenses), time-space formula, self-employment…

  14. Steppin' On Up: A Post-Secondary Guide for Migrant Students = Tomando Accion: Una Guia para los Estudiantes Migrantes Sobre Que Hacer Despues de la Escuela Secundaria.

    ERIC Educational Resources Information Center

    Western Stream Migrant Education Program Coordination Center, Portland, OR.

    This bilingual guide (English and Spanish) provides information for migrant students on postsecondary education. The guide includes information on: (1) career planning, involving self-exploration, occupational exploration, and strategies for reaching career objectives; (2) planning for postsecondary education during high school, including a…

  15. The Effect of Direct and Indirect Corrective Feedback on Students' Spelling Errors (El efecto de la retroalimentación directa e indirecta sobre los errores de ortografía de los estudiantes)

    ERIC Educational Resources Information Center

    Baleghizadeh, Sasan; Dadashi, Mehdi

    2011-01-01

    The study presented here is an attempt to examine the role of indirect feedback in promoting junior high school students' spelling accuracy in English. It compares the effect of direct feedback with indirect feedback on students' written work dictated by their teacher from their textbooks. Two classes were selected from the Zanjanrood District in…

  16. Simulations of flow interactions near Los Alamos

    SciTech Connect

    Costigan, K. R.; Winterkamp, Judy; Bossert, J. E.; Langley, D. L.

    2002-01-01

    The Pajarito Plateau is located on the eastern flank of the Jemez Mountains and the west side of the Rio Grande Valley, in north-central New Mexico, where the river runs roughly north to south. On the Pajarito Plateau, a network of surface meteorological stations has been routinely maintained by Los Alamos National Laboratory. This network includes five instrumented towers, within an approximately 10 km by 15 km area. The towers stand from 23 m to 92 m tall, with multiple wind measurement heights. Investigation of the station records indicates that the wind fields can be quite complicated and may be the result of interactions of thermally and/or dynamically driven flows of many scales. Slope flows are often found on the plateau during the morning and evening transition times, but it is not unusual to find wind directions that are inconsistent with slope flows at some or all of the stations. It has been speculated that valley circulations, as well as synoptically driven winds, interact with the slope flows, but the mesonet measurements alone, with no measurements in the remainder of the valley, were not sufficient to investigate this hypothesis. Thus, during October of 1995, supplemental meteorological instrumentation was placed in the Rio Grande basin to study the complex interaction of flows in the area. A sodar was added near the 92 m tower and a radar wind profiler was placed in the Rio Grande Valley, just east of the plateau and near the river. Measurements were also added at the top of Pajarito Mountain, just west of the plateau, and across the valley, to the east, on top of Tesuque Peak (in the Sangre de Cristo Mountains). Two surface stations were also added to the north-facing slopes of Pajarito Mountain. This paper will present observations from October 1995 and results of simulations of this area that are used in the study of the complex interaction of dynamically and thermally driven flows on multiple scales.

  17. Methane Hotspots in the Los Angeles Megacity

    NASA Astrophysics Data System (ADS)

    Hopkins, F. M.; Randerson, J. T.; Bush, S.; Ehleringer, J. R.; Lai, C.; Kort, E. A.; Blake, D. R.

    2013-12-01

    Airborne observations show that Los Angeles (LA) is a large source of methane to the atmosphere, yet the sources of excess methane from the urban area are poorly constrained. We used a mobile laboratory, a Ford Transit van equipped with cavity ring down spectrometers (Picarro, Inc.), to measure greenhouse gases (CH4, CO2, and CO) mole fractions in LA. On-road surveys across the LA Basin were conducted seasonally to determine patterns of CH4 enrichment in space and over time, with a focus on quantifying methane leaks from known sources. We found fugitive leaks and elevated CH4 concentrations throughout the LA Basin. Some were associated with known sources, such as landfills, wastewater treatment, and oil and gas infrastructure, while others had an unknown origin. Urban CH4 enrichment varied over the course of the year, largely due to seasonal changes in meteorological conditions. Nevertheless, our mobile surveys revealed CH4 hotspots (>200 ppb elevated with respect to background levels) that persisted among seasons. High CH4 concentrations were most easily predicted by proximity to methane sources, particularly near the coast, while elevated CH4 levels were more evenly dispersed in inland areas. CH4 hotspots had a disproportionate impact on excess methane relative to the area they accounted for, typically providing more than a quarter of excess methane measured on a transect. These data improve estimates of the relative roles of specific leaks and emission sectors to LA's excess methane. Depending on the cost of reducing these CH4 leaks, a focus on CH4 emissions may prove an effective way to reduce LA's greenhouse gas emissions in the near term.

  18. Recent UCN source developments at Los Alamos

    SciTech Connect

    Seestrom, S.J.; Anaya, J.M.; Bowles, T.J.

    1998-12-01

    The most intense sources of ultra cold neutrons (UCN) have bee built at reactors where the high average thermal neutron flux can overcome the low UCN production rate to achieve usable densities of UCN. At spallation neutron sources the average flux available is much lower than at a reactor, though the peak flux can be comparable or higher. The authors have built a UCN source that attempts to take advantage of the high peak flux available at the short pulse spallation neutron source at the Los Alamos Neutron Science Center (LANSCE) to generate a useful number of UCN. In the source UCN are produced by Doppler-shifted Bragg scattering of neutrons to convert 400-m/s neutrons down into the UCN regime. This source was initially tested in 1996 and various improvements were made based on the results of the 1996 running. These improvements were implemented and tested in 1997. In sections 2 and 3 they discuss the improvements that have been made and the resulting source performance. Recently an even more interesting concept was put forward by Serebrov et al. This involves combining a solid Deuterium UCN source, previously studied by Serebrov et al., with a pulsed spallation source to achieve world record UCN densities. They have initiated a program of calculations and measurements aimed at verifying the solid Deuterium UCN source concept. The approach has been to develop an analytical capability, combine with Monte Carlo calculations of neutron production, and perform benchmark experiments to verify the validity of the calculations. Based on the calculations and measurements they plan to test a modified version of the Serebrov UCN factory. They estimate that they could produce over 1,000 UCN/cc in a 15 liter volume, using 1 {micro}amp of 800 MeV protons for two seconds every 500 seconds. They will discuss the result UCN production measurements in section 4.

  19. Smog chamber simulation of Los Angeles pollutant transport

    SciTech Connect

    Glasson, W.A.

    1981-06-01

    A smog chamber study simulated pollutant transport from Los Angeles to downwind areas by irradiating a typical Los Angeles hydrocarbon/nitrogen oxides mixture for extended periods of time. Smog chamber experiments were extended to 22 hr to obtain an integrated light intensity equal to that which occurs in this city. Results show that downwind oxidant levels are only slightly affected by large changes in emissions of nitrogen oxides. However, it is clear that reduced emissions will lead to an increase in oxidant in downtown Los Angeles. (6 graphs, 9 references, 1 table)

  20. 83. FIRST AND SECOND AQUEDUCTS LOOKING EAST/NORTHEAST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    83. FIRST AND SECOND AQUEDUCTS LOOKING EAST/NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  1. DOE Los Alamos National Laboratory – PV Feasibility Assessment, 2015 Update, NREL Final Report

    SciTech Connect

    Dean, Jesse; Witt, Monica Rene

    2016-04-06

    This report summarizes solar and wind potential for Los Alamos National Laboratory (LANL). This report is part of the “Los Alamos National Laboratory and Los Alamos County Renewable Generation” study.

  2. 11. GRANT LAKE AND MONO LAKE LOOKING NORTH/NORTHEAST Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. GRANT LAKE AND MONO LAKE LOOKING NORTH/NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  3. 10. GRANT LAKE AND MONO LAKE LOOKING EAST/NORTHEAST Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. GRANT LAKE AND MONO LAKE LOOKING EAST/NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  4. 91. FAIRMONT RESERVOIR, LOOKING WEST/NORTHWEST Los Angeles Aqueduct, From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    91. FAIRMONT RESERVOIR, LOOKING WEST/NORTHWEST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  5. The Origins of Mexico's Universidad de los Ninos.

    ERIC Educational Resources Information Center

    Levy, Raquel

    1989-01-01

    The article describes an after school program, the Universidad de los Ninos, in Mexico City, for children with special abilities. The program stresses development of individual potential, a flexible curriculum, parent involvement, and development of social responsibility. (DB)

  6. RadNet Air Data From Los Angeles, CA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Los Angeles, CA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  7. Tesoro Los Angeles Refinery Integration and Compliance Project

    EPA Pesticide Factsheets

    EPA Region 9 has two announcements pertaining to the Los Angeles Refinery Integration and Compliance project (LARIC project): permit revisions meet all CAA requirements and federal PSD permitting provisions do not apply to this project.

  8. Public Hearing on Cruise Ship Discharges: Los Angeles

    EPA Pesticide Factsheets

    Transcripts of the presentation and comments provided at a hearing hosted by the EPA in Los Angeles, CA on discharges from cruise ships. Stakeholder representatives were in attendance to provide information and recommendations on this issue.

  9. Explosive Flux Compression: 50 Years of Los Alamos Activities

    SciTech Connect

    Fowler, C.M.; Thomson, D.B.; Garn, W.B.

    1998-10-18

    Los Alamos flux compression activities are surveyed, mainly through references in view of space limitations. However, two plasma physics programs done with Sandia National Laboratory are discussed in more detail.

  10. Los Angeles Library Fire--Learning the Hard Way.

    ERIC Educational Resources Information Center

    Morris, John

    1987-01-01

    Describes the damage and salvage efforts resulting from the burning of the Los Angeles Central Library in 1986, and makes several recommendations for fire and arson prevention measures and contingency salvage plans. (CLB)

  11. Review of liquid metal heat pipe work at Los Alamos

    SciTech Connect

    Reid, R.S.; Merrigan, M.A.; Sena, J.T. )

    1991-01-10

    A survey of space-power related liquid metal heat pipe work at Los Alamos National Laboratory is presented. Heat pipe development at Los Alamos has been on-going since 1963. Heat pipes were initially developed for thermionic nuclear-electrical power production in space. Since then Los Alamos has developed liquid metal heat pipes for numerous applications related to high temperature systems in both the space and terrestrial environments. Some of these applications include thermionic electrical generators, thermoelectric energy conversion (both in-core and direct radiation), thermal energy storage, hypersonic vehicle leading edge cooling, and heat pipe vapor laser cells. Some of the work performed at Los Alamos has been documented in internal reports that are often little-known. A representative description and summary of progress in space-related liquid metal heat pipe technology is provided followed by a reference section citing sources where these works may be found.

  12. Los Alamos National Laboratory Prepares for Fire Season

    SciTech Connect

    L’Esperance, Manny

    2016-07-18

    Through the establishment of a Wildland Fire Program Office, and the Interagency Fire Base located on Laboratory property, Los Alamos National Laboratory is continuing and improving a program to prepare for wildland fire.

  13. Sima de los Huesos (Sierra de Atapuerca, Spain). The site.

    PubMed

    Arsuaga, J L; Martínez, I; Gracia, A; Carretero, J M; Lorenzo, C; García, N

    1997-01-01

    In this article a topographical description of the Cueva Mayor Cueva de Silo cave system is provided, including a more detailed topography of the Sala de los Ciclopes Sala de las Oseras-Sima de los Huesos sector. The history of the excavations and discoveries of human and carnivore fossils in Sima de los Huesos and adjacent passages is briefly reported, as well as the increase, throughout the succeeding field seasons, of the human collection and changes in the relative representation of the different skeletal elements and major biases. The carnivore assemblage structure is also considered. Examining the characteristics of the bone breccia, and the current and ancient karst topography, different alternative accesses are discussed for the accumulation of carnivores and humans in the Sima de los Huesos. Taking into account all the available information, an anthropic origin for the accumulation of human fossils seems to us to be the most likely explanation.

  14. Explosive Flux Compression:. 50 Years of LOS Alamos Activities

    NASA Astrophysics Data System (ADS)

    Fowler, C.; Thomson, D.; Garn, W.

    2004-11-01

    Los Alamos flux compression activities are surveyed, mainly through references in view of space limitations. However, two plasma physics programs done with Sandia National Laboratory are discussed in more detail.

  15. Review of liquid metal heat pipe work at Los Alamos

    SciTech Connect

    Reid, R.S.; Merrigan, M.A.; Sena, J.T.

    1990-01-01

    A survey of space-power related liquid metal heat pipe work at Los Alamos National Laboratory is presented. Heat pipe development at Los Alamos has been on-going since 1963. Heat pipes were initially developed for thermionic nuclear-electrical power production in space. Since then Los Alamos has developed liquid metal heat pipes for numerous applications related to high temperature systems in both the space and terrestrial environments. Some of these applications include thermionic electrical generators, thermoelectric energy conversion (both in-core and direct radiation), thermal energy storage, hypersonic vehicle leading edge cooling, and heat pipe vapor laser cells. Some of the work performed at Los Alamos has been documented in internal reports that are often little-known. A representative description and summary of progress in space-related liquid metal heat pipe technology is provided followed by a reference section citing sources where these works may be found. 53 refs.

  16. Home Tutorials vs. the Public Schools in Los Angeles.

    ERIC Educational Resources Information Center

    Weaver, Roy A.; And Others

    1980-01-01

    Examines the Home Tutorial Program in the San Fernando Valley of California in the areas of organization, parent attitudes, learning environment, achievement, and socialization. Compare the home program with the Los Angeles Unified School District. (IRT)

  17. Los Alamos National Laboratory Prepares for Fire Season

    ScienceCinema

    L’Esperance, Manny

    2016-08-10

    Through the establishment of a Wildland Fire Program Office, and the Interagency Fire Base located on Laboratory property, Los Alamos National Laboratory is continuing and improving a program to prepare for wildland fire.

  18. Photo Gallery from the Los Angeles River Watershed (California)

    EPA Pesticide Factsheets

    Photo gallery of the Los Angeles River Watershed area of the Urban Waters Federal Partnership (UWFP) reconnects urban communities with their waterways by improving coordination among federal agencies and collaborating with community-led efforts.

  19. Los Angeles, California, Radar Image, Wrapped Color as Height

    NASA Image and Video Library

    2000-02-17

    This topographic radar image acquired by NASA Shuttle Radar Topography Mission SRTM in Feb. 2000 shows the relationships of the dense urban development of Los Angeles, Calif. and the natural contours of the land.

  20. The Origins of Mexico's Universidad de los Ninos.

    ERIC Educational Resources Information Center

    Levy, Raquel

    1989-01-01

    The article describes an after school program, the Universidad de los Ninos, in Mexico City, for children with special abilities. The program stresses development of individual potential, a flexible curriculum, parent involvement, and development of social responsibility. (DB)

  1. Final Ferry Takes SCA-Endeavour Over Los Angeles

    NASA Image and Video Library

    Space shuttle Endeavour atop NASA's Shuttle Carrier Aircraft overflew many landmarks in Los Angeles to conclude its final ferry flight into history on Sept. 21, 2012. Among highlights in this video...

  2. South Central Los Angeles: A Community in Transition.

    ERIC Educational Resources Information Center

    Lum, Lydia

    2001-01-01

    Discusses how Los Angeles Southwest College perhaps best illustrates the rising tide of Latinos and other minorities sweeping into higher education institutions of deeply steeped Black heritage, and the challenges and new growing pains such schools face. (EV)

  3. Million trees Los Angeles canopy cover and benefit assessment

    Treesearch

    E.G. McPherson; J.R. Simpson; Q. Xiao; C. Wu

    2011-01-01

    The Million Trees LA initiative intends to improve Los Angeles’s environment through planting and stewardship of 1 million trees. The purpose of this study was to measure Los Angeles’s existing tree canopy cover (TCC), determine if space exists for 1 million additional trees, and estimate future benefits from the planting. High-resolution QuickBird remote sensing data...

  4. Assessing urban forest effects and values, Los Angeles' urban forest

    Treesearch

    David J. Nowak; Robert E. III Hoehn; Daniel E. Crane; Lorraine Weller; Antonio. Davila

    2011-01-01

    An analysis of trees in Los Angeles, CA, reveals that this area has about 6 million trees with tree and shrub canopies that cover 24.9 percent of the city. The most common tree species are Italian cypress, scrub oak, laurel sumac, Mexican fan palm, and Indian laurel, Trees in Los Angeles currently store about 1.3 million tons of carbon (4.7 million tons CO2...

  5. Strategic defense initiatives at Los Alamos National Laboratory

    SciTech Connect

    Rockwood, S.D.

    1985-01-01

    This presentation reviews the Strategic Defense Initiative (SDI) programs at Los Alamos National Laboratory, noting especially the needs for and applications of optics and optical technologies. Table I lists the various activities at Los Alamos contributing to SDI programs. The principal, nonnuclear SDI programs are: (1) the free-electron laser, and (2) neutral particle beams. Both should be considered as potential long-range-kill systems, but still in the futuristic category.

  6. Los Alamos low-level waste performance assessment status

    SciTech Connect

    Wenzel, W.J.; Purtymun, W.D.; Dewart, J.M.; Rodgers, J.E.

    1986-06-01

    This report reviews the documented Los Alamos studies done to assess the containment of buried hazardous wastes. Five sections logically present the environmental studies, operational source terms, transport pathways, environmental dosimetry, and computer model development and use. This review gives a general picture of the Los Alamos solid waste disposal and liquid effluent sites and is intended for technical readers with waste management and environmental science backgrounds but without a detailed familiarization with Los Alamos. The review begins with a wide perspective on environmental studies at Los Alamos. Hydrology, geology, and meteorology are described for the site and region. The ongoing Laboratory-wide environmental surveillance and waste management environmental studies are presented. The next section describes the waste disposal sites and summarizes the current source terms for these sites. Hazardous chemical wastes and liquid effluents are also addressed by describing the sites and canyons that are impacted. The review then focuses on the transport pathways addressed mainly in reports by Healy and Formerly Utilized Sites Remedial Action Program. Once the source terms and potential transport pathways are described, the dose assessment methods are addressed. Three major studies, the waste alternatives, Hansen and Rogers, and the Pantex Environmental Impact Statement, contributed to the current Los Alamos dose assessment methodology. Finally, the current Los Alamos groundwater, surface water, and environmental assessment models for these mesa top and canyon sites are described.

  7. Los Angeles: The Most Differentiated Basaltic Martian Meteorite

    NASA Technical Reports Server (NTRS)

    Rubin, Alan E.; Warren, Paul H.; Greenwood, James P.; Verish, Robert S.; Leshin, Laurie A.; Hervig, Richard L.; Clayton, Robert N.; Mayeda, Toshiko K.

    2000-01-01

    Los Angeles is a new martian meteorite that expands the compositional range of basaltic shergottites. Compared to Shergotty, Zagami, QUE94201, and EET79001-B, Los Angeles is more differentiated, with higher concentrations of incompatible elements (e.g., La) and a higher abundance of late-stage phases such as phosphates and K-rich feldspathic glass. The pyroxene crystallization trend starts at compositions more ferroan than in other martian basaits. Trace elements indicate a greater similarity to Shergotty and Zagami than to QUE94201 or EET79001-B, but the Mg/Fe ratio is low even compared to postulated parent melts of Shergotty and Zagami. Pyroxene in Los Angeles has 0.7-4-microns-thick exsolution lamellae, approx. 10 times thicker than those in Shergotty and Zaganii. Opaque oxide compositions suggest a low equilibration temperature at an oxygen fugacity near the fayafite-magnetitequartz buffer. Los Angeles cooled more slowly than Shergotty and Zagami. Slow cooling, coupled with the ferroan bulk composition, produced abundant fine-grained intergrowths of fayalite, hedenbergite, and silica, by the breakdown of pyroxferroite. Shock effects in Los Angeles include maskelynitized plagioclase, pyroxene with mosaic extinction, and rare fault zones. One such fault ruptured a previously decomposed zone of pyroxferroite. Although highly differentiated, the bulk composition of Los Angeles is not close to the low-Ca/Si composition or the globally wind-stirred soil of Mars.

  8. Audit of consultant agreements at Los Alamos National Laboratory

    SciTech Connect

    1996-02-23

    The Department of Energy`s (Department) Albuquerque Operations Office (Albuquerque) and Los Alamos National Laboratory (Los Alamos) are responsible for acquiring consulting services in a manner most advantageous to the Government by ensuring adequate competition. Although the Department prefers competitively awarding subcontracts, including consultant agreements, to ensure the lowest possible cost, it allows sole sourcing a subcontract if the sole source is fully justified. The objective of the audit was to determine whether Los Alamos` consultant agreements contained adequate sole source justifications. The audit showed that Los Alamos may not have acquired some of its consultant agreements at the lowest possible cost because it did not prepare adequate sole source justifications for 17 sole source consultant agreements valued at $842,900. This condition existed because: (1) requesters did not follow policies and procedures when preparing sole source justifications, (2) Los Alamos did not have an internal mechanism to reject consultant agreements that were not adequately justified, and (3) the Department did not review consultant agreements to evaluate the adequacy of sole source justifications. Without adequate justifications, the Department cannot be assured that consultant services were obtained at the lowest possible cost. We therefore recommended that the Manager, Albuquerque Operations Office require Los Alamos to ensure proper sole source justifications and enhance internal controls over consultant agreements. Management agreed to implement the recommendations.

  9. Lo que los Padres Necesitan Saber sobre...Reconocer y Animar los Intereses, las Capacidades, y los Talentos de los Ninos Dotados de la Escuela Primaria. Guia Practica B0213 (What Parents Need To Know about...Recognizing and Encouraging Interests, Strengths, and Talents of Gifted Elementary School Children. Practitioners' Guide B0213).

    ERIC Educational Resources Information Center

    Delcourt, Marcia A. B.

    This brochure, written in Spanish, discusses strategies that Spanish-speaking parents can use to support the interests of their children and how to recognize and extend their children's talents. Parents are urged to: (1) be aware of what their child likes to do and be patient with the changing patterns as the child explores areas of interests and…

  10. Lo Que los Padres Necesitan Saber sobre...Reconocer y Animar los Intereses, las Capacidades, y los Talentos de los Adolescentes. Guia Practica B0214 (What Parents Need To Know about...Recognizing Interests, Strengths, and Talents of Gifted Adolescents. Practitioners' Guide B0214).

    ERIC Educational Resources Information Center

    Delcourt, Marcia A. B.

    This brochure, written in Spanish, for Spanish-speaking parents of gifted adolescents discusses strategies to use to support the interests of their children and how to recognize and extend their children's talents. Parents are urged to: (1) increase their knowledge about the child's areas of interest; (2) discuss the child's present and future…

  11. Lo Que los Padres Necesitan Saber sobre...Reconocer y Animar los Intereses, las Capacidades, y los Talentos de los Ninos Dotados Jovenes. Guia Practica B0212 (What Parents Need To Know about...Recognizing and Encouraging Interests, Strengths, and Talents of Young Gifted Children. Practitioners' Guide B0212).

    ERIC Educational Resources Information Center

    Delcourt, Marcia A. B.

    This pamphlet, written in Spanish, is designed to help Spanish-speaking parents recognize and encourage their gifted preschool children. It begins by discussing some of the interests of very young children and lists strategies for facilitating and supporting those interests, including: provide the child with opportunities to find out about a…

  12. 1993 Northern goshawk inventory on portions of Los Alamos National Laboratory, Los Alamos, NM. Final report

    SciTech Connect

    Sinton, D.T.; Kennedy, P.L.

    1994-06-01

    Northern goshawks (Accipiter gentilis) (hereafter referred to as goshawk) is a large forest dwelling hawk. Goshawks may be declining in population and reproduction in the southwestern United States. Reasons for the possible decline in goshawk populations include timber harvesting resulting in the loss of nesting habitat, toxic chemicals, and the effects of drought, fire, and disease. Thus, there is a need to determine their population status and assess impacts of management activities in potential goshawk habitat. Inventory for the goshawk was conducted on 2,254 ha of Los Alamos National Laboratory (LANL) to determine the presence of nesting goshawks on LANL lands. This information can be incorporated into LANL`s environmental management program. The inventory was conducted by Colorado State University personnel from May 12 to July 30, 1993. This report summarizes the results of this inventory.

  13. Perspective View, SRTM / Landsat, Los Angeles, Calif

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Los Angeles, Calif., is one of the world's largest metropolitan areas with a population of about 15 million people. The urban areas mostly cover the coastal plains and lie within the inland valleys. The intervening and adjacent mountains are generally too rugged for much urban development. This in large part because the mountains are 'young', meaning they are still building (and eroding) in this seismically active (earthquake prone) region.

    Earthquake faults commonly lie between the mountains and the lowlands. The San Andreas fault, the largest fault in California, likewise divides the very rugged San Gabriel Mountains from the low-relief Mojave Desert, thus forming a straight topographic boundary between the top center and lower right corner of the image. We present two versions of this perspective image from NASA's Shuttle Radar Topography Mission (SRTM): one with and one without a graphic overlay that maps faults that have been active in Late Quaternary times (white lines). The fault database was provided by the U.S. Geological Survey.

    For the annotated version of this image, please select Figure 1, below: [figure removed for brevity, see original site] (Large image: 2 mB jpeg)

    The Landsat image used here was acquired on May 4, 2001, about seven weeks before the summer solstice, so natural terrain shading is not particularly strong. It is also not especially apparent given a view direction (northwest) nearly parallel to the sun illumination (shadows generally fall on the backsides of mountains). Consequently, topographic shading derived from the SRTM elevation model was added to the Landsat image, with a false sun illumination from the left (southwest). This synthetic shading enhances the appearance of the topography.

    Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and substantially helps in analyzing the large and

  14. Perspective View, SRTM / Landsat, Los Angeles, Calif

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Los Angeles, Calif., is one of the world's largest metropolitan areas with a population of about 15 million people. The urban areas mostly cover the coastal plains and lie within the inland valleys. The intervening and adjacent mountains are generally too rugged for much urban development. This in large part because the mountains are 'young', meaning they are still building (and eroding) in this seismically active (earthquake prone) region.

    Earthquake faults commonly lie between the mountains and the lowlands. The San Andreas fault, the largest fault in California, likewise divides the very rugged San Gabriel Mountains from the low-relief Mojave Desert, thus forming a straight topographic boundary between the top center and lower right corner of the image. We present two versions of this perspective image from NASA's Shuttle Radar Topography Mission (SRTM): one with and one without a graphic overlay that maps faults that have been active in Late Quaternary times (white lines). The fault database was provided by the U.S. Geological Survey.

    For the annotated version of this image, please select Figure 1, below: [figure removed for brevity, see original site] (Large image: 2 mB jpeg)

    The Landsat image used here was acquired on May 4, 2001, about seven weeks before the summer solstice, so natural terrain shading is not particularly strong. It is also not especially apparent given a view direction (northwest) nearly parallel to the sun illumination (shadows generally fall on the backsides of mountains). Consequently, topographic shading derived from the SRTM elevation model was added to the Landsat image, with a false sun illumination from the left (southwest). This synthetic shading enhances the appearance of the topography.

    Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and substantially helps in analyzing the large and

  15. Environmental Investigations and Analyses for Los Angeles-Long Beach Harbors, Los Angeles, California, 1973-1976.

    DTIC Science & Technology

    1976-12-01

    sity of Southern California . pp. 65-78. Juge, D. M. 1971. Marine geomicrobiology of the southern California continental borderland . Unpublished doctoral...4D-A136 653 ENVIRONMENTAL INVESTIGATIONS AND, ANALYSES FOR LOS 1/8 ANGELES-LONG BEACH HARB..(U) UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES ALLAN...HARBORS ENVIRONMENTAL PROJECTS M.u 1~4 ___ INSTITUTE FOR MARINE AND COASTAL STUDIES i L~a...ALLAN HANCOCK FOUNDATION UNIVERSITY OF SOUTHERN CALIFORNIA

  16. Desarrollo de la Escala sobre el Estigma Relacionado con el VIH/SIDA para Profesionales de la Salud mediante el uso de métodos mixtos123

    PubMed Central

    Varas-Díaz, Nelson; Neilands, Torsten B.; Guilamo-Ramos, Vincent; Cintrón Bou, Francheska N.

    2009-01-01

    El estigma relacionado con el VIH/SIDA continúa siendo un obstáculo para la prevención primaria y secundaria del VIH. Las consecuencias para las personas que viven con la enfermedad han sido muy documentadas y continúan siendo una gran preocupación para las personas que proveen servicios de salud y para aquellas que investigan el tema. Estas consecuencias son preocupantes cuando el estigma emana de profesionales de la salud porque se puede limitar el acceso a los servicios. Uno de los principales obstáculos para la investigación del estigma relacionado con el VIH en Puerto Rico es la falta de instrumentos cuantitativos para evaluar las manifestaciones del estigma entre profesionales de la salud. El objetivo principal de este estudio fue desarrollar y probar las propiedades psicométricas de una escala sobre el estigma relacionado con el VIH/SIDA culturalmente apropiada para personas que proveen servicios de salud puertorriqueñas y desarrollar una versión corta de la escala que pudiera usarse en escenarios clínicos con tiempo limitado. El instrumento desarrollado estuvo basado en evidencia cualitativa recopilada entre profesionales y estudiantes de profesiones de la salud puertorriqueños/as (n=80) y administrado a una muestra de 421 profesionales de la salud en adiestramiento. La escala contenía 12 dimensiones del estigma relacionado con el VIH/SIDA. El análisis cuantitativo corroboró 11 de ellas, teniendo como resultado un instrumento con validez y confiabilidad satisfactoria. Estas dimensiones, a su vez, fueron subcomponentes de un factor de estigma general superior. PMID:20333258

  17. Some Research-Based Issues and Recommendations Expressed at the Seminario Internacional Sobre la Educacion Bilingue.

    ERIC Educational Resources Information Center

    Bernal, Ernesto M.

    The first Seminario Internacional Sobre la Educacion Bilingue (International Seminar on Bilingual Education), under the aegis of the National Association for Bilingual Education and the Mexican secretary for public education, brought together professionals from Canada, the United States, and Mexico in Oaxtepec, Mexico in November 1986 to share…

  18. Obtenga más información sobre la etiqueta Safer Choice

    EPA Pesticide Factsheets

    Entérese más acerca del programa EPA Diseño para el medio ambiente, incluyendo información sobre su historia, proyectos anteriores y otros programas de la EPA que están relacionados con este programa.

  19. Guía para la evaluación del riesgo de los polinizadores

    EPA Pesticide Factsheets

    La Guía para la evaluación del riesgo de los polinizadores de la EPA es parte de una estrategia de la evaluación de los riesgos que presentan los pesticidas para las abejas a fin de mejorar la protección de los polinizadores.

  20. Distinción Empírica Entre Engagement y Trabajolismo en Enfermeras Hospitalarias de Japón: Efecto Sobre la Calidad del Sueño y el Desempeño Laboral

    PubMed Central

    Kubota, Kazumi; Shimazu, Akihito; Kawakami, Norito; Takahashi, Masaya; Nakata, Akinori; Schaufeli, Wilmar B.

    2016-01-01

    Objetivo El objetivo de este estudio es demostrar la distinción entre engagement y trabajolismo, estudiando su relación con la calidad del sueño y el desempeño laboral. Método Un total de 447 enfermeras de 3 hospitales de Japón fueron entrevistadas mediante un cuestionario autoadministrado que incluía la escala Utrecht (UWES, Utrecht Work Engagement Scale), la Escala de Adicción al Trabajo Holandesa (DUWAS, Dutch Workaholism Scale), preguntas sobre la calidad del sueño (7 ítems) con respecto a (1) dificultad para conciliar el sueño, (2) dificultad para mantener el sueño, (3) despertar temprano por la mañana, (4) dormirse o tomar siestas durante el día, (5) somnolencia diurna excesiva en el trabajo, (6) dificultad para despertarse por la mañana, y (7) despertar cansado en la mañana, y el Cuestionario sobre Salud y Desempeño (CSD) de la Organización Mundial de la Salud. Resultados Los modelos de ecuaciones estructurales demostraron que el engagement se relaciona positivamente con la calidad del sueño y el rendimiento laboral, mientras que el trabajolismo tiene una relación negativa con la calidad del sueño y el desempeño laboral. Conclusión Los resultados indican que el engagement y el trabajolismo son conceptualmente diferentes. El primero tiene una connotación positiva, mientras que el segundo se asocia de manera negativa al bienestar (buena calidad del sueño y buen rendimiento en el trabajo). PMID:26752805

  1. Ecosystem studies at the Los Medanos site, Eddy County, New Mexico. Volume I

    SciTech Connect

    Hart, J.S.

    1981-05-01

    This report summarizes the results of biological studies conducted during 1980 at the Los Medanos site in southeastern New Mexico. The studies include: (1) densities and species composition of the avifauna of the Los Medanos site; (2) aquatic ecosystems of the lower Pecos drainage; (3) floristic studies at the Los Medanos site; (4) plant successional, grazing, trampling, and salt studies on the Los Medanos site; (5) soil and vegetation studies at the Los Medanos site; (6) arthropod and decomposition studies at the WIPP site; (7) amphibians, reptiles and mammals at the Los Medanos site; (8) vertebrate ecology at the Los Medanos site; and (9) statistical analysis and data management. 7 refs. (ACR)

  2. Environmental Survey preliminary report, Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect

    Not Available

    1988-01-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy's (DOE) Los Alamos National Laboratory (LANL), conducted March 29, 1987 through April 17, 1987. The Survey is being conducted by an interdisciplinary team of environmental specialists, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. Individual team components are outside experts being supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with the LANL. The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. The on-site phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at the LANL, and interviews with site personnel. The Survey team developed Sampling and Analysis Plan to assist in further assessing certain of the environmental problems identified during its on-site activities. The Sampling and Analysis Plan will be executed by the Idaho National Engineering Laboratory. When completed, the results will be incorporated into the LANL Environmental Survey Interim Report. The Interim Report will reflect the final determinations of the Survey for the LANL. 65 refs., 68 figs., 73 tabs.

  3. Environmental assessment for effluent reduction, Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect

    1996-09-11

    The Department of Energy (DOE) proposes to eliminate industrial effluent from 27 outfalls at Los Alamos National Laboratory (LANL). The Proposed Action includes both simple and extensive plumbing modifications, which would result in the elimination of industrial effluent being released to the environment through 27 outfalls. The industrial effluent currently going to about half of the 27 outfalls under consideration would be rerouted to LANL`s sanitary sewer system. Industrial effluent from other outfalls would be eliminated by replacing once-through cooling water systems with recirculation systems, or, in a few instances, operational changes would result in no generation of industrial effluent. After the industrial effluents have been discontinued, the affected outfalls would be removed from the NPDES Permit. The pipes from the source building or structure to the discharge point for the outfalls may be plugged, or excavated and removed. Other outfalls would remain intact and would continue to discharge stormwater. The No Action alternative, which would maintain the status quo for LANL`s outfalls, was also analyzed. An alternative in which industrial effluent would be treated at the source facilities was considered but dismissed from further analysis because it would not reasonably meet the DOE`s purpose for action, and its potential environmental effects were bounded by the analysis of the Proposed Action and the No Action alternatives.

  4. Publications of Los Alamos research, 1977-1981

    SciTech Connect

    Sheridan, C.J.; Garcia, C.A.

    1983-03-01

    This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1977-1981. Papers published in those years are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted - even those papers, themselves unclassified, which were published only as part of a classified document. If a paper was published more than once, all places of publication are included. The bibliography includes Los Alamos National Laboratory reports, papers released as non-Laboratory reports, journal articles, books, chapters of books, conference papers either published separately or as part of conference proceedings issued as books or reports, papers published in congressional hearings, theses, and US patents. Publications by Los Alamos authors that are not records of Laboratory-sponsored work are included when the Library becomes aware of them.

  5. Water Supply at Los Alamos 1998-2001

    SciTech Connect

    Richard J. Koch; David B. Rogers

    2003-03-01

    For the period 1998 through 2001, the total water used at Los Alamos from all sources ranged from 1325 million gallons (Mg) in 1999 to 1515 Mg in 2000. Groundwater production ranged from 1323 Mg in 1999 to 1506 Mg in 2000 from the Guaje, Pajarito, and Otowi fields. Nonpotable surface water used from Los Alamos reservoir ranged from zero gallons in 2001 to 9.3 Mg in 2000. For years 1998 through 2001, over 99% of all water used at Los Alamos was groundwater. Water use by Los Alamos National Laboratory (LANL) between 1998 and 2001 ranged from 379 Mg in 2000 to 461 Mg in 1998. The LANL water use in 2001 was 393 Mg or 27% of the total water use at Los Alamos. Water use by Los Alamos County ranged from 872 Mg in 1999 to 1137 Mg in 2000, and averaged 1006 Mg/yr. Four new replacement wells in the Guaje field (G-2A, G-3A, G-4A, and G-5A) were drilled in 1998 and began production in 1999; with existing well G-1A, the Guaje field currently has five producing wells. Five of the old Guaje wells (G-1, G-2, G-4, G-5, and G-6) were plugged and abandoned in 1999, and one well (G-3) was abandoned but remains as an observation well for the Guaje field. The long-term water level observations in production and observation (test) wells at Los Alamos are consistent with the formation of a cone of depression in response to water production. The water level decline is gradual and at most has been about 0.7 to 2 ft per year for production wells and from 0.4 to 0.9 ft/yr for observation (test) wells. The largest water level declines have been in the Guaje field where nonpumping water levels were about 91 ft lower in 2001 than in 1951. The initial water levels of the Guaje replacement wells were 32 to 57 ft lower than the initial water levels of adjacent original Guaje wells. When production wells are taken off-line for pump replacement or repair, water levels have returned to within about 25 ft of initial static levels within 6 to 12 months. Thus, the water-level trends suggest no adverse

  6. Professional Identity at Los Angeles College of Chiropractic.

    PubMed

    Kimura, Melissa Nagare; Russell, Robb; Scaringe, John

    2016-12-01

    The objective of this article is to describe chiropractic professional identity as espoused by the Los Angeles College of Chiropractic. Professional identity is a construct that begins formation prior to career selection, can be considered the backbone of health care education, and has been linked to career success. Los Angeles College of Chiropractic's professional identity is shaped by a philosophy of health care that is focused on vitalism, holism, naturalism, therapeutic conservatism, critical rationalism, phenomenology, humanism, and interprofessionalism. Other distinguishing aspects include portal-of-entry professionals with broad diagnostic skills; a focus on spine care; promotion of public-health; and delivery of manual treatments. The chiropractic professional identity at the Los Angeles College of Chiropractic focuses on serving the needs of the people who entrust their health to its graduates and will continue to evolve on the basis of many factors, such as politics, social perceptions, and economic conditions.

  7. A progress report on UNICOS misuse detection at Los Alamos

    SciTech Connect

    Thompson, J.L.; Jackson, K.A.; Stallings, C.A.; Simmonds, D.D.; Siciliano, C.L.B.; Pedicini, G.A.

    1995-10-01

    An effective method for detecting computer misuse is the automatic monitoring and analysis of on-line user activity. During the past year, Los Alamos enhanced its Network Anomaly Detection and Intrusion Reporter (NADIR) to include analysis of user activity on Los Alamos` UNICOS Crays. In near real-time, NADIR compares user activity to historical profiles and tests activity against expert rules. The expert rules express Los Alamos` security policy and define improper or suspicious behavior. NADIR reports suspicious behavior to security auditors and provides tools to aid in follow-up investigations. This paper describes the implementation to date of the UNICOS component of NADIR, along with the operational experiences and future plans for the system.

  8. Water supply at Los Alamos during 1993. Progress report

    SciTech Connect

    Purtymun, W.D.; Stoker, A.K.; McLin, S.G.; Maes, M.N.; Glasco, T.A.

    1995-10-01

    This report summarizes production and aquifer conditions for water wells in the Guaje, Pajarito, and Otowi Well Fields. These wells supplied all of the potable water used for municipal and some industrial purposes in Los Alamos County and the Los Alamos National Laboratory during 1993. The wells in the Los Alamos Well Field were transferred to San Ildefonso Pueblo in 1992. Four of the wells in the Los Alamos Well Field were plugged in 1993. One of the two new wells in the Otowi Well Field became operational in 1993. The spring gallery in Water Canyon supplied nonpotable water for industrial use, while surface water from the Los Alamos Reservoir was diverted for irrigation. In 1993 no water was used from the Guaje Reservoir. Due to the maintenance and operating cost of diverting water from the reservoirs, it is not economically feasible to continue their use for irrigation. This report fulfills some of the requirements of the Los Alamos Groundwater Protection Management Program by documenting use of the groundwater for water supply and providing information hydrologic characteristics of the main aquifer. This report is a joint effort between the Laboratory Water Quality and Hydrology Group and the Utilities Department of Johnson Controls World Services Inc. (JCI). The purpose of this report is to ensure a continuing historical record and to provide guidance for management of water resources in long-range planning for the water supply system. We have issued one summary report for the period of 1947 to 1971 and 22 annual reports that contain the results of our studies of these water supplies. An additional report summarized the hydrology of the main aquifer with reference to future development of groundwater supplies. A report was issued in 1988 that examined the status of wells and future water supply.

  9. A 30-Year Retrospective: Degrees of Difficulty in Decreasing LOS.

    PubMed

    Zander, Karen

    2016-01-01

    In an attempt to avoid future revisionist history, the author offers a 30-year retrospective (1986-2016) on the evolution of strategies to reduce length of stay (LOS). She and her colleagues have been involved from the onset by developing tools such as critical paths, roles such as clinical case management, and operational systems for managing measureable outcome-driven care from the bedside to the boardroom. Acute care hospitals. The LOS for all inpatients has changed dramatically from 1970 (average LOS = 7.8 days) through solidly between 2005 and 2012 (average LOS = 4.5 days in 2012) despite a significant increase in the average age of hospital inpatients (; ). For patients 65 years and older, who comprised 38% of all inpatients, the decrease has been more drastic: from 12.6 days in 1970 to 5.5 days in 2005-2010 ().With the exception of hospitalists and case management staff, acute care hospitals have essentially doubled productivity without adding additional direct care full-time equivalents! Described in terms of "low-hanging" to "high-hanging" fruit, this article outlines the classic methods used to reduce LOS and concludes with some implications of LOS for health care reform. The U.S. health system could not have accomplished this feat without case managers and social workers. Acute care services should be very proud of their achievements and use their reputation to empower their work for the next frontier, which will be reducing cost per case, especially in risk contracts. Everything old seems new again.

  10. A physicists guide to The Los Alamos Primer

    NASA Astrophysics Data System (ADS)

    Reed, B. Cameron

    2016-11-01

    In April 1943, a group of scientists at the newly established Los Alamos Laboratory were given a series of lectures by Robert Serber on what was then known of the physics and engineering issues involved in developing fission bombs. Serber’s lectures were recorded in a 24 page report titled The Los Alamos Primer, which was subsequently declassified and published in book form. This paper describes the background to the Primer and analyzes the physics contained in its 22 sections. The motivation for this paper is to provide a firm foundation of the background and contents of the Primer for physicists interested in the Manhattan Project and nuclear weapons.

  11. A Los Angeles Basin 1100 Aircraft Traffic Model,

    DTIC Science & Technology

    1981-01-01

    air traffic model of the Los Angeles basin for the same year, described in Reference 1. LAX-1100 revises that model by using current air traffic...summarizes the relevant methodology of the original LAX-1840 model. Section 2.2 summarizes the new forecasts used for revising LAX-1840. Section 2.3...ve i’, ’ Lad 1(174, 1096 and 1105 aircraft respectively. 1, 1c ,rc rf t mo.’ was chosen as the revised Los Angeles ’* d CIr va named LAX-i 1(11. L 4

  12. The development of the atomic bomb, Los Alamos

    SciTech Connect

    Seidel, R.W.

    1993-11-01

    The historical presentation begins with details of the selection of Los Alamos as the site of the Army installation. Wartime efforts of the Army Corps of Engineers, and scientists to include the leader of Los Alamos, Robert Oppenheimer are presented. The layout and construction of the facilities are discussed. The monumental design requirements of the bombs are discussed, including but not limited to the utilization of the second choice implosion method of detonation, and the production of bomb-grade nuclear explosives. The paper ends with a philosophical discussion on the use of nuclear weapons.

  13. Los Alamos Using Neutrons to Stop Nuclear Smugglers

    SciTech Connect

    Favalli, Andrea; Swinhoe, Martyn

    2013-06-03

    Los Alamos National Laboratory researchers have successfully demonstrated for the first time that laser-generated neutrons can be enlisted as a useful tool in the War on Terror. The international research team used the short-pulse laser at Los Alamos's TRIDENT facility to generate a neutron beam with novel characteristics that interrogated a closed container to confirm the presence and quantity of nuclear material inside. The successful experiment paves the way for creation of a table-top-sized or truck-mounted neutron generator that could be installed at strategic locations worldwide to thwart smugglers trafficking in nuclear materials.

  14. Fifty-one years of Los Alamos Spacecraft

    SciTech Connect

    Fenimore, Edward E.

    2014-09-04

    From 1963 to 2014, the Los Alamos National Laboratory was involved in at least 233 spacecraft. There are probably only one or two institutions in the world that have been involved in so many spacecraft. Los Alamos space exploration started with the Vela satellites for nuclear test detection, but soon expanded to ionospheric research (mostly barium releases), radioisotope thermoelectric generators, solar physics, solar wind, magnetospheres, astrophysics, national security, planetary physics, earth resources, radio propagation in the ionosphere, and cubesats. Here, we present a list of the spacecraft, their purpose, and their launch dates for use during RocketFest

  15. Los Alamos Using Neutrons to Stop Nuclear Smugglers

    ScienceCinema

    Favalli, Andrea; Swinhoe, Martyn

    2016-07-12

    Los Alamos National Laboratory researchers have successfully demonstrated for the first time that laser-generated neutrons can be enlisted as a useful tool in the War on Terror. The international research team used the short-pulse laser at Los Alamos's TRIDENT facility to generate a neutron beam with novel characteristics that interrogated a closed container to confirm the presence and quantity of nuclear material inside. The successful experiment paves the way for creation of a table-top-sized or truck-mounted neutron generator that could be installed at strategic locations worldwide to thwart smugglers trafficking in nuclear materials.

  16. Contributions of chemistry in early day Los Alamos

    SciTech Connect

    Penneman, R.A.; Meade, R.A.

    1990-01-01

    During 1943--1945, the premier physics laboratory in the world was at Los Alamos, but chemistry contributions were vital. Major chemical impacts on the success of the Los Alamos wartime mission included electrochemistry, which found the true melting point of plutonium metal to be hundreds of degrees lower than anticipated. This discovery had profound simplifying effects regarding crucibles to contain molten plutonium and on its production. Other significant chemical contributions involved constant purification of plutonium for reuse, producing carrier-free gamma sources at unprecedented kilo-curie levels, and high polonium work. 8 refs.

  17. Pilot fruit drier for Los Azufres geothermal field, Michoacan, Mexico

    SciTech Connect

    Lund, J.W.

    1993-02-01

    Comision Federal de Electricidad (CFE) has a Division in charge of the exploration of a geothermal reservoir located in Los Azufres, State of Michoacan. At present, CFE is only using the steam of the wells and rejecting the hot water that comes off associated with the steam. Based on a trip to the Los Azufres geothermal field in December of 1992, a design for a pilot geothermal fruit drier was undertaken for CFE. The details of the geothermal field and the local fruit production are detailed.

  18. Pilot fruit drier for Los Azufres geothermal field, Michoacan, Mexico

    SciTech Connect

    Lund, J.W.

    1993-02-01

    Comision Federal de Electricidad (CFE) has a Division in charge of the exploration of a geothermal reservoir located in Los Azufres, State of Michoacan. At present, CFE is only using the steam of the wells and rejecting the hot water that comes off associated with the steam. Based on a trip to the Los Azufres geothermal field in December of 1992, a design for a pilot geothermal fruit drier was undertaken for CFE. The details of the geothermal field and the local fruit production are detailed.

  19. Needs assessment for fire department services and resources for the Los Alamos National Laboratory, Los Alamos, New Mexico. Final report

    SciTech Connect

    1995-11-15

    This report has been developed in response to a request from the Los Alamos National Laboratory (LANL) to evaluate the need for fire department services so as to enable the Laboratory to plan effective fire protection and thereby: meet LANL`s regulatory and contractual obligations; interface with the Department of Energy (DOE) and other agencies on matters relating to fire and emergency services; and ensure appropriate protection of the community and environment. This study is an outgrowth of the 1993 Fire Department Needs Assessment (prepared for DOE) but is developed from the LANL perspective. Input has been received from cognizant and responsible representatives at LANL, DOE, Los Alamos County (LAC) and the Los Alamos Fire Department (LAFD).

  20. Effects of an acute bout of exercise on serum soluble leptin receptor (sOB-R) levels.

    PubMed

    Yang, Chung Bing; Chuang, Chung-Chief; Kuo, Chung Sen; Hsu, Chin Hsing; Tsao, Te Hung

    2014-01-01

    We investigated the effects of an acute bout of exercise on serum soluble leptin receptor (sOB-R) concentrations. Eighteen male participants completed two different exercise sessions with intensities of 25% and 65% maximal aerobic capacity (VO2max). In addition to the energy expenditure during exercise sessions being measured, blood samples were collected before exercise, and immediately, at 24 h, and at 48 h post-exercise to analyse sOB-R, leptin and insulin levels. At 24 h post-exercise, sOB-R and leptin concentrations at the 65% VO2max were significantly different from those at the 25% VO2max. Leptin levels at 48 h post-exercise were also significantly lower for the 65% VO2max than for the 25% VO2max (P < 0.01). In the 65% VO2max session, the energy expenditure during exercise was significantly associated with leptin concentrations at 24 h and 48 h and sOB-R concentrations at 24 h post-exercise. However, no correlations were found between sOB-R and leptin at the three post-exercise time points. In conclusion, an acute bout of exercise with 920 kcal of output resulted in an increase in sOB-R levels at 24 h post-exercise. However, the changes in sOB-R levels due to an acute bout of exercise might not contribute to the delayed decrease observed for leptin.

  1. A survey of macromycete diversity at Los Alamos National Laboratory, Bandelier National Monument, and Los Alamos County; A preliminary report

    SciTech Connect

    Jarmie, N.; Rogers, F.J.

    1997-11-01

    The authors have completed a 5-year survey (1991--1995) of macromycetes found in Los Alamos County, Los Alamos National Laboratory, and Bandelier National Monument. The authors have compiled a database of 1,048 collections, their characteristics, and identifications. The database represents 123 (98%) genera and 175 (73%) species reliably identified. Issues of habitat loss, species extinction, and ecological relationships are addressed, and comparisons with other surveys are made. With this baseline information and modeling of this baseline data, one can begin to understand more about the fungal flora of the area.

  2. Experiencias sobre el impacto del Programa de Formación en Ética de la Investigación Biomédica y Psicosocial en el ámbito de la salud mental y la investigación conductual.

    PubMed

    Barrios, Liliana Mondragón

    2012-01-01

    El propósito de este trabajo es presentar el impacto y la integración que los conocimientos adquiridos en el Programa Internacional de Formación en Ética de la Investigación Biomédica y Psicosocial de la Universidad de Chile han tenido en mi experiencia profesional, en el ámbito de la investigación psicosocial en un Instituto de Salud de México. Para este objetivo, expondré tres áreas en las cuales se ha podido evidenciar tal impacto: trabajo en los comités de ética, desarrollo de programas de académicos en bioética e investigación y publicación sobre ética y bioética. El motivo que me llevó a incursionar en el Programa fue que su enseñanza vincula la investigación psicosocial con la ética y la bioética, lo cual me permitió dirigir este tipo de reflexión hacia problemas como violencia, suicidio, adicciones, depresión y salud mental, y a nuevos campos como los estudios comunitarios, con poblaciones en riesgo o vulnerables, en los cuales las diversas implicaciones son difíciles de indagar.

  3. Experiencias sobre el impacto del Programa de Formación en Ética de la Investigación Biomédica y Psicosocial en el ámbito de la salud mental y la investigación conductual

    PubMed Central

    Barrios, Liliana Mondragón

    2012-01-01

    El propósito de este trabajo es presentar el impacto y la integración que los conocimientos adquiridos en el Programa Internacional de Formación en Ética de la Investigación Biomédica y Psicosocial de la Universidad de Chile han tenido en mi experiencia profesional, en el ámbito de la investigación psicosocial en un Instituto de Salud de México. Para este objetivo, expondré tres áreas en las cuales se ha podido evidenciar tal impacto: trabajo en los comités de ética, desarrollo de programas de académicos en bioética e investigación y publicación sobre ética y bioética. El motivo que me llevó a incursionar en el Programa fue que su enseñanza vincula la investigación psicosocial con la ética y la bioética, lo cual me permitió dirigir este tipo de reflexión hacia problemas como violencia, suicidio, adicciones, depresión y salud mental, y a nuevos campos como los estudios comunitarios, con poblaciones en riesgo o vulnerables, en los cuales las diversas implicaciones son difíciles de indagar. PMID:22754085

  4. Sobre las soluciones acotadas del problema instantáneo de dos cuerpos

    NASA Astrophysics Data System (ADS)

    Altavista, C.

    La demostración se basa en el hecho de que las integrales del problema de los N-cuerpos admiten componentes en el campo complejo según las raíces n-ésimas de la unidad. Definida la matriz unitaria correspondiente, la fórmula de Cayley permite transformar la matriz unitaria en una matriz hermitiana. Utilizando como parámetros los cosenos direccionales de un sistema de coordenadas orbitales referidos a un sistema de referencia fijo, puede construirse, utilizando el operador hermitiano antes definido, una forma cuadrática cuyas raíces mínima y máxima definen las cotas respectivas de los movimientos de los mencionados cosenos direccionales.

  5. Dia de los Muertos: An Illustrated Essay and Bibliography.

    ERIC Educational Resources Information Center

    California Univ., Santa Barbara. University Library.

    Among Mexico's most original traditions is the holiday dedicated to honoring the dead, Dia de los Muertos, November 2. This tradition combines aspects that define the national spirit. At the same time that it is a solemn festivity to remember the dead, it becomes a fiesta in its own right. Death, more than a thing to be feared, becomes the motif…

  6. Food Buying Practices of Mexican Americans in East Los Angeles.

    ERIC Educational Resources Information Center

    Lewis, Jane S.; And Others

    As part of a pilot study of the nutritional status of Mexican American preschool children attending Head Start in East Los Angeles in the spring of 1969, questions were asked concerning their families' buying and food practices. This paper reports on the information obtained from the 21 questionnaires which were returned. Answers to the following…

  7. Brief review of Rover fuel development at Los Alamos

    NASA Technical Reports Server (NTRS)

    Davidson, Keith V.

    1991-01-01

    A brief review of the graphite matrix uranium fuel development efforts at Los Alamos from 1955 through 1972 is presented. The uses of graphite flour carbon black, various binders, uranium dioxide, coated UC2 particles, and zirconium carbide in this development are described.

  8. FINE PORE DIFFUSER FOULING: THE LOS ANGELES STUDIES

    EPA Science Inventory

    This report describes five fine pore diffuser evaluations conducted at three different wastewater treatment plants located in the greater Los Angeles area. The overall goal of the study was to evaluate the performance of fine pore diffusers using selected cleaning methods for ex...

  9. Plasma and ion beam processing at Los Alamos

    SciTech Connect

    Rej, D.J.; Davis, H.A.; Henins, I.

    1994-07-01

    Efforts are underway at Los Alamos National Laboratory to utilize plasma and intense ion beam science and technology of the processing of advanced materials. A major theme involves surface modification of materials, e.g., etching, deposition, alloying, and implantation. In this paper, we concentrate on two programs, plasma source ion implantation and high-intensity pulsed ion beam deposition.

  10. The Widening Divide: Income Inequality and Poverty in Los Angeles.

    ERIC Educational Resources Information Center

    Castellanos, Eulalio; And Others

    This document summarizes findings from the Research Project on Income Inequality and Poverty in Los Angeles. The figures reported are based on an analysis of published and unpublished data sets, including the Public Use Microdata Sets for the 1970 and 1980 decennial Census of Population, the Current Population Surveys, and the American Housing…

  11. Control de los escombros tras un desastre natural

    EPA Pesticide Factsheets

    PONER EN LA ACERA LOS ESCOMBROS QUE DEJA UN HURACÁN EN LAS ÁREAS PARTICIPANTES. Si sigue estas pautas específicas (PDF) se acelerará el proceso de recolección. Confirme con las autoridades del gobierno local lo que le corresponda a usted.

  12. Desentrañar los secretos de Mercurio

    NASA Image and Video Library

    De todos los planetas rocosos, Mercurio es el más pequeño y denso, el que posee la superficie más antigua y el que tiene las variaciones diarias de temperatura más amplias. También es el menos expl...

  13. The Los Alamos nuclear safeguards and nonproliferation technology development program

    SciTech Connect

    Smith, H.A. Jr.; Menlove, H.O.; Reilly, T.D.; Bosler, G.E.; Hakkila, E.A.; Eccleston, G.W.

    1994-04-01

    For nearly three decades, Los Alamos National Laboratory has developed and implemented nuclear measurement technology and training in support of national and international nuclear safeguards. This paper outlines the major elements of those technologies and highlights some of the latest developments.

  14. Aqueous Nitrate Recovery Line at Los Alamos National Laboratory

    SciTech Connect

    Finstad, Casey Charles

    2016-06-15

    This powerpoint is part of the ADPSM Plutonium Engineering Lecture Series, which is an opportunity for new hires at LANL to get an overview of work done at TA55. It goes into detail about the aqueous nitrate recovery line at Los Alamos National Laboratory.

  15. Drop Out Patterns in the East Los Angeles Community College

    ERIC Educational Resources Information Center

    Waktola, Daniel K.

    2014-01-01

    This study attempted to analyze the drop out problem from spatial perspectives within the context of East Los Angeles Community College, California. Selected urban land-use types, which positively and negatively influence the propensity to drop out or persist-in colleges, were selected and captured during a global positioning system (GPS)-based…

  16. Asi Son los Puertorriquenos (These Are the Puerto Ricans).

    ERIC Educational Resources Information Center

    Kane, Joan K.

    "Asi Son los Puertorriquenos" immerses the student of Spanish in the language and culture of Puerto Rico. The program is designed to simultaneously improve language skills and develop understanding and appreciation of the culture. The reading selections are challenging for the intermediate level, and provide valuable insight into many…

  17. [Los Alamos National Laboratory industrial applications and technology transfer

    SciTech Connect

    Not Available

    1992-09-30

    In October 1989, the Los Alamos Economic Development Corporation (LAEDC) entered into a contract with the Industrial Applications office (IAO) of Los Alamos National Laboratory (LANL) whereby the LAEDC was to provide support services to IAO. More specifically, according to the Statement of Work in this contract The Los Alamos Economic Development Corporation shall assist the Los Alamos National Laboratory Industrial Applications Office in establishing and strengthening connections between potential entrepreneurs at the Laboratory and the business assistance community throughout New Mexico, directed toward enhancing the number, of successful start up businesses spinning off the Laboratory's technology base.'' As part of this contract and subsequent modifications thereof, the LAEDC was to perform seven tasks: 1. Provide business planning assistance to potential entrepreneurs. 2. (Assist IAO in preparing and distributing) informational materials on technology transfer. 3. (Organize and manage) meetings and seminars on technology transfer and entrepreneurship. 4. Identify new opportunities for technology transfer. 5. (Identify and implement programs for the) recognition of Laboratory Entrepreneurs. 6. Training Lab personnel, in the area of technology transfer and Laboratory industrial interactions. 7. Review and summarize prior New Mexico economic development studies. The purpose of this report, is to summarize the accomplishments of the LAEDC under its contract with IAO, and to fulfill its reporting requirements. This report covers the period from October 1989 to September 1992.

  18. SOFT FLOOR COVERING IN THE LOS ANGELES CITY SCHOOL DISTRICTS.

    ERIC Educational Resources Information Center

    CUNLIFF, DONALD D.

    A STUDY REGARDING THE INSTALLATION OF CARPET IN SCHOOLS IS DISCUSSED. THE PURPOSE OF THE STUDY WAS TO HAVE A CONSULTANT REVIEW UNDER THE DIRECTION OF THE DISTRICT BUILDING AND GROUNDS SERVICES ADMINISTRATOR OF THE LOS ANGELES CITY SCHOOL DISTRICTS, THE SOFT FLOOR COVERING INSTALLATIONS AT ARAGON AVENUE AND TWENTY-FOURTH STREET SCHOOLS. SECTIONS…

  19. Housing in Los Angeles: Affordable Housing for the Future.

    ERIC Educational Resources Information Center

    Los Angeles Blue Ribbon Committee for Affordable Housing, CA.

    A 1988 mayoral committee assessed the seriousness of Los Angeles (California) housing problems and found that the city's housing efforts were sufficient in the 1960s, when the Federal Government took primary responsibility for housing and the average wage was adequate to support the cost of the average house or apartment. However, the following…

  20. Los Angeles, California as seen from STS-59

    NASA Image and Video Library

    1994-04-14

    STS059-227-050 (9-20 April 1994) --- A low altitude, and unusually clear air, provided perhaps the most detailed view of Los Angeles, California ever obtained during a shuttle flight. Orient with the bulk of the ocean to the lower left. Then Long Beach is in the lower right, just east of the Palos Verdes Hills that extend into the Pacific Ocean. Marina del Rey is cut into the straight segment of beach, with Los Angeles International Airport (LAX) clearly visible to the southeast. Downtown Los Angeles is the light-toned sprawl in the upper right, with the rectangular grid pattern of Pasadena extending out of the picture. The Santa Monica Mountains to the upper left extend east-west, separating the San Fernando Valley (epicenter of the 1993 earthquake) from the Los Angeles Basin proper. It is impossible to determine by photo interpretation whether or not the de-vegetated scars along the southern edge of the mountains represent man-made features (real-estate development) or wildfires.

  1. Arts in Focus: Los Angeles Countywide Arts Education Survey.

    ERIC Educational Resources Information Center

    2001

    This report baseline study information about the state of arts education in Los Angeles County, California, the most populous county in the United States. Students in the districts covered in this survey represent 27% of all students enrolled in California public schools (K-12) and 3.4% of all students enrolled in U.S. public schools. The survey's…

  2. Utilice en forma segura los productos con cebo para roedores

    EPA Pesticide Factsheets

    Si se usan de manera inadecuada, los productos con veneno para ratas y ratones podrían hacerle daño a usted, a sus hijos o a sus mascotas. Siempre que use pesticidas lea la etiqueta del producto y siga todas las indicaciones.

  3. State of the District [Los Angeles Community College District].

    ERIC Educational Resources Information Center

    Koltai, Leslie

    Accomplishments made by the Los Angeles Community College District during its fifth year of independent operation are noted, and 10 projects to receive attention during the coming year are listed. The accomplishments are: (1) increasing and diversifying enrollment, (2) stabilizing and improving the college environment, (3) developing fiscal…

  4. Los Alamos high-power proton linac designs

    SciTech Connect

    Lawrence, G.P.

    1995-10-01

    Medium-energy high-power proton linear accelerators have been studied at Los Alamos as drivers for spallation neutron applications requiring large amounts of beam power. Reference designs for such accelerators are discussed, important design factors are reviewed, and issues and concern specific to this unprecedented power regime are discussed.

  5. Los Angeles School Board Race Shatters Spending Records

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2013-01-01

    The price tag to win a seat in this week's primary election for the Los Angeles school board climbed to unprecedented levels, as a massive influx of outside cash has turned a local campaign into a national showdown pitting the long-standing influence of teachers' unions against the expanding imprint of deep-pocketed education activists. The high…

  6. The Widening Divide: Income Inequality and Poverty in Los Angeles.

    ERIC Educational Resources Information Center

    Castellanos, Eulalio; And Others

    This document summarizes findings from the Research Project on Income Inequality and Poverty in Los Angeles. The figures reported are based on an analysis of published and unpublished data sets, including the Public Use Microdata Sets for the 1970 and 1980 decennial Census of Population, the Current Population Surveys, and the American Housing…

  7. The Controlled-Air Incinerator at Los Alamos

    SciTech Connect

    Newmyer, J.N.

    1994-04-01

    The Controlled-Air Incinerator (CAI) at Los Alamos is being modified and upgraded to begin routine operations treating low-level mixed waste (LLMW), radioactively contaminated polychlorinated biphenyl (PCB) wastes, low-level liquid wastes, and possibly transuranic (TRU) wastes. This paper describes those modifications. Routine waste operations should begin in late FY95.

  8. Linking Planning, Quality Improvement and IR: Los Angeles City College

    ERIC Educational Resources Information Center

    Seymour, Daniel

    2004-01-01

    Stung by a negative accreditation review, Los Angeles City College established an administrative position and a planning process that is successfully creating a culture of continuous improvement. At the core of this success is a "plan-act-check" reinforcing systems loop that links planning, budgeting, and institutional research. (Contains 2…

  9. AmeriFlux US-Los Lost Creek

    DOE Data Explorer

    Desai, Ankur [University of Wisconsin

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Los Lost Creek. Site Description - Shrub wetland site, chosen to be representative of the wetlands within the WLEF tall tower flux footprint. This is a deciduous shrub wetland. Coniferous and grassy stands also exist within the WLEF flux footprint. Solar power. The site has excellent micrometeorological characteristics.

  10. Working Smart: The Los Angeles Workplace Literacy Project. Final Report.

    ERIC Educational Resources Information Center

    Los Angeles Unified School District, CA. Div. of Adult and Occupational Education.

    The Working Smart workplace literacy project was sponsored by a public school district and several profit and nonprofit companies and conducted for the hotel and food industry in the Los Angeles area. Literacy instruction was merged with job requirements of the customer service job classifications. Videodisc courseware was developed, as were…

  11. Drop Out Patterns in the East Los Angeles Community College

    ERIC Educational Resources Information Center

    Waktola, Daniel K.

    2014-01-01

    This study attempted to analyze the drop out problem from spatial perspectives within the context of East Los Angeles Community College, California. Selected urban land-use types, which positively and negatively influence the propensity to drop out or persist-in colleges, were selected and captured during a global positioning system (GPS)-based…

  12. Los Angeles 1-Million tree canopy cover assessment

    Treesearch

    Gregory E. McPherson; James R. Simpson; Qingfu Xiao; Wu Chunxia

    2008-01-01

    The Million Trees LA initiative intends to chart a course for sustainable growth through planting and stewardship of trees. The purpose of this study was to measure Los Angeles's existing tree canopy cover (TCC), determine if space exists for 1 million additional trees, and estimate future benefits from the planting. High resolution QuickBird remote sensing data,...

  13. Dia de los Muertos: A Joyful Mexican Celebration

    ERIC Educational Resources Information Center

    Markello, Carrie; Bean, Kathy

    2005-01-01

    This brief article describes the history, traditions, and food of the Mexican holiday known as Dia de los Muertos, or the Day of the Day, and explores classroom and studio activities that teachers can do with their students. Teachers are urged to encourage students to explore the topic of the Day of the Dead, comparing it to other traditions and…

  14. Urban America: Policy Choices for Los Angeles and the Nation.

    ERIC Educational Resources Information Center

    Steinberg, James B., Ed.; And Others

    This volume presents 13 essays on urban problems in the United States, particularly in Los Angeles (California) following the 1992 riots, and policy options for the future. Part 1 addresses policies of the past three decades; Part 2 looks at children, youth, and families; Part 3 discusses crime and criminal justice; and Part 4 examines public…

  15. Mercury: The Los Alamos ICF KrF laser system

    SciTech Connect

    Czuchlewski, S.J.; York, G.W.; Bigio, I.J.; Brucker, J.; Hanson, D.; Honig, E.M.; Kurnit, N.; Leland, W.; McCown, A.W.; McLeod, J.; Rose, E.; Thomas, S.; Thompson, D.

    1993-01-19

    The Mercury KrF laser facility at Los Alamos is being built with the benefit of lessons learned from the Aurora system. An increased understanding of KrF laser engineering, and the designed implementation of system flexibility, will permit Mercury to serve as a tested for a variety of advanced KrF technology concepts.

  16. Waste management at Los Alamos: Protecting our environment

    SciTech Connect

    Not Available

    1993-11-01

    This report consists of a broad overview of activities at Los Alamos National Laboratory (LANL). The following topics are discussed: The growth of the waste management group; what we do today; the mission of the waste management group; the liquid waste treatment section; the radioactive liquid waste project office; the chemical waste section; the radioactive waste section; and the technical support section.

  17. 40. Topeka and Santa Fe Railway Company, Los Angeles, California, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. Topeka and Santa Fe Railway Company, Los Angeles, California, dated July 1937. (Microfiched drawings located at the Denver Service Center, #113/41906-set of 2) IMPROVEMENTS IN SEWAGE TREATMENT AND FILTER CHAMBER. - Water Reclamation Plant, Grand Canyon, Coconino County, AZ

  18. Homicide Followed by Suicide: Los Angeles, 1970-1979.

    ERIC Educational Resources Information Center

    Allen, Nancy H.

    1983-01-01

    Compared 104 homicides followed by suicide in Los Angeles during 1970-1979 to West's findings for England and Wales, 1954-1961. Variables discussed are age, ethnicity, sex distribution of offenders and victims, relationship between them, methods, alcohol content, suicide notes, depression, and physical illness. (JAC)

  19. Housing in Los Angeles: Affordable Housing for the Future.

    ERIC Educational Resources Information Center

    Los Angeles Blue Ribbon Committee for Affordable Housing, CA.

    A 1988 mayoral committee assessed the seriousness of Los Angeles (California) housing problems and found that the city's housing efforts were sufficient in the 1960s, when the Federal Government took primary responsibility for housing and the average wage was adequate to support the cost of the average house or apartment. However, the following…

  20. Demographic Paradoxes in the Los Angeles Voting Rights Case.

    ERIC Educational Resources Information Center

    Clark, William A. V.; Morrison, Peter A.

    1991-01-01

    How technical demographic analysis can inform and confuse judicial considerations of voting rights principles is illustrated in a review of a 1990 case brought against Los Angeles County (California). A postscripted article considers whether the court involved should rely on after-census estimates for redistricting. (SLD)