Core Fueling of DEMO by Direct Line Injection of High-Speed Pellets From the HFS

DOE PAGES

Frattolillo, Antonio; Baylor, Larry R.; Bombarda, Francesca; ...

2018-04-17

Pellet injection represents to date the most realistic candidate technology for core fueling of a demonstration fusion power reactor tokamak fusion reactor. Modeling of both pellet penetration and fuel deposition profiles, for different injection locations, indicates that effective core fuelling can be achieved launching pellets from the inboard high field side at speeds not less than ~ 1 km/s. Inboard pellet fueling is commonly achieved in present tokamaks, using curved guide tubes; however, this technology might be hampered at velocities ≥ 1 km/s. An innovative approach, aimed at identifying suitable inboard "direct line'' paths, to inject high-speed pellets (in themore » 3 to 4 km/s range), has recently been proposed as a potential complementary solution. The fuel deposition profiles achievable by this approach have been explored using the HPI2 simulation code. The results presented here show that there are possible geometrical schemes providing good fueling performance. The problem of neutron flux in a direct line-of-sight injection path is being investigated, though preliminary analyses indicate that, perhaps, this is not a serious problem. The identification and integration of straight injection paths suitably tilted may be a rather difficult task due to the many constraints and to interference with existing structures. The suitability of straight guide tubes to reduce the scatter cone of high-speed pellets is, therefore, of main interest. A preliminary investigation, aimed at addressing these technological issues, has recently been started. As a result, a possible implementation plan, using an existing Italian National Agency for New Technologies, Energy and Sustainable Economic Development-Oak Ridge National Laboratory facility is shortly outlined.« less

Core Fueling of DEMO by Direct Line Injection of High-Speed Pellets From the HFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frattolillo, Antonio; Baylor, Larry R.; Bombarda, Francesca

Pellet injection represents to date the most realistic candidate technology for core fueling of a demonstration fusion power reactor tokamak fusion reactor. Modeling of both pellet penetration and fuel deposition profiles, for different injection locations, indicates that effective core fuelling can be achieved launching pellets from the inboard high field side at speeds not less than ~ 1 km/s. Inboard pellet fueling is commonly achieved in present tokamaks, using curved guide tubes; however, this technology might be hampered at velocities ≥ 1 km/s. An innovative approach, aimed at identifying suitable inboard "direct line'' paths, to inject high-speed pellets (in themore » 3 to 4 km/s range), has recently been proposed as a potential complementary solution. The fuel deposition profiles achievable by this approach have been explored using the HPI2 simulation code. The results presented here show that there are possible geometrical schemes providing good fueling performance. The problem of neutron flux in a direct line-of-sight injection path is being investigated, though preliminary analyses indicate that, perhaps, this is not a serious problem. The identification and integration of straight injection paths suitably tilted may be a rather difficult task due to the many constraints and to interference with existing structures. The suitability of straight guide tubes to reduce the scatter cone of high-speed pellets is, therefore, of main interest. A preliminary investigation, aimed at addressing these technological issues, has recently been started. As a result, a possible implementation plan, using an existing Italian National Agency for New Technologies, Energy and Sustainable Economic Development-Oak Ridge National Laboratory facility is shortly outlined.« less

Experiment T001: Entry communication on the Gemini 3 mission

NASA Technical Reports Server (NTRS)

Schroeder, L. C.; Sims, T. E.; Cuddihy, W. F.

1971-01-01

Water addition to the Gemini 3 exhaust plasma was studied to determine its effectiveness in the establishment of communication links during the entry portion of the flight. Attenuation levels were measured with and without water injection at uhf frequencies of 230.4 and 296.8 megahertz and at the C-band frequency of 5690 megahertz. Ultrahigh frequency signals that had been blacked out were restored to significant levels, during early portions of the water-injection sequence, by the high flow rate injection. The C-band signal was enhanced by medium and high flow rate injections during the latter portion of the injection period. The uhf signal recovered during water injection resulted in an antenna pattern that was beamed in the radial direction of injection from the spacecraft. Postflight analysis showed that the uhf recovery data were consistent with injection-penetration theory.

Computational modeling of the effect of external electron injection into a direct-current microdischarge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panneer Chelvam, Prem Kumar; Raja, Laxminarayan L.

2015-12-28

Electron emission from the electrode surface plays an important role in determining the structure of a direct-current microdischarge. Here we have developed a computational model of a direct-current microdischarge to study the effect of external electron injection from the cathode surface into the discharge to manipulate its properties. The model provides a self-consistent, multi-species, multi-temperature fluid representation of the plasma. A microdischarge with a metal-insulator-metal configuration is chosen for this study. The effect of external electron injection on the structure and properties of the microdischarge is described. The transient behavior of the microdischarge during the electron injection is examined. Themore » nonlinearities in the dynamics of the plasma result in a large increase of conduction current after active electron injection. For the conditions simulated a switching time of ∼100 ns from a low-current to high-current discharge state is realized.« less

On the effect of injection timing on the ignition of lean PRF/air/EGR mixtures under direct dual fuel stratification conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luong, Minh Bau; Sankaran, Ramanan; Yu, Gwang Hyeon

2017-06-09

The ignition characteristics of lean primary reference fuel (PRF)/air/exhaust gas recirculation (EGR) mixture under reactivity-controlled compression ignition (RCCI) and direct duel fuel stratification (DDFS) conditions are investigated in this paper by 2-D direct numerical simulations (DNSs) with a 116-species reduced chemistry of the PRF oxidation. The 2-D DNSs of the DDFS combustion are performed by varying the injection timing of iso-octane (i-C 8H 18) with a pseudo-iso-octane (PC 8H 18) model together with a novel compression heating model to account for the compression heating and expansion cooling effects of the piston motion in an engine cylinder. The PC 8H 18more » model is newly developed to mimic the timing, duration, and cooling effects of the direct injection of i-C 8H 18 onto a premixed background charge of PRF/air/EGR mixture with composition inhomogeneities. It is found that the RCCI combustion exhibits a very high peak heat release rate (HRR) with a short combustion duration due to the predominance of the spontaneous ignition mode of combustion. However, the DDFS combustion has much lower peak HRR and longer combustion duration regardless of the fuel injection timing compared to those of the RCCI combustion, which is primarily attributed to the sequential injection of i-C 8H 18. It is also found that the ignition delay of the DDFS combustion features a non-monotonic behavior with increasing fuel-injection timing due to the different effect of fuel evaporation on the low-, intermediate-, and high-temperature chemistry of the PRF oxidation. The budget and Damköhler number analyses verify that although a mixed combustion mode of deflagration and spontaneous ignition exists during the early phase of the DDFS combustion, the spontaneous ignition becomes predominant during the main combustion, and hence, the spread-out of heat release rate in the DDFS combustion is mainly governed by the direct injection process of i-C 8H 18. Finally, a misfire is observed for the DDFS combustion when the direct injection of i-C 8H 18 occurs during the intermediate-temperature chemistry (ITC) regime between the first- and second-stage ignition. Finally, this is because the temperature drop induced by the direct injection of i-C 8H 18 impedes the main ITC reactions, and hence, the main combustion fails to occur.« less

Focal plane infrared readout circuit

NASA Technical Reports Server (NTRS)

Pain, Bedabrata (Inventor)

2002-01-01

An infrared imager, such as a spectrometer, includes multiple infrared photodetectors and readout circuits for reading out signals from the photodetectors. Each readout circuit includes a buffered direct injection input circuit including a differential amplifier with active feedback provided through an injection transistor. The differential amplifier includes a pair of input transistors, a pair of cascode transistors and a current mirror load. Photocurrent from a photodetector can be injected onto an integration capacitor in the readout circuit with high injection efficiency at high speed. A high speed, low noise, wide dynamic range linear infrared multiplexer array for reading out infrared detectors with large capacitances can be achieved even when short exposure times are used. The effect of image lag can be reduced.

Decreased Odds of Injection Risk Behavior Associated With Direct Versus Indirect Use of Syringe Exchange: Evidence From Two California Cities.

PubMed

Behrends, Czarina N; Li, Chin-Shang; Gibson, David R

2017-07-29

While there is substantial evidence that syringe exchange programs (SEPs) are effective in preventing HIV among people who inject drugs (PWID), nearly all the evidence comes from PWID who obtain syringes from an SEP directly. Much less is known about the benefits of secondary exchange to PWID who get syringes indirectly from friends or acquaintances who visit an SEP for them. We evaluated the effectiveness of direct versus indirect syringe exchange in reducing HIV-related high-risk injecting behavior among PWID in two separate studies conducted in Sacramento and San Jose, California, cities with quite different syringe exchange models. In both studies associations between direct and indirect syringe exchange and self-reported risk behavior were examined with multivariable logistic regression models. Study 1 assessed effects of a "satellite" home-delivery syringe exchange in Sacramento, while Study 2 evaluated a conventional fixed-site exchange in San Jose. Multivariable analyses revealed 95% and 69% reductions, respectively, in high-risk injection associated with direct use of the SEPs in Sacramento and San Jose, and a 46% reduction associated with indirect use of the SEP in Sacramento. Conclusions/Importance: The very large effect of direct SEP use in Sacramento was likely due in part to home delivery of sterile syringes. While more modest effects were associated with indirect use, such use nevertheless is valuable in reducing the risk of HIV transmission of PWID who are unable or unwilling to visit a syringe exchange.

New functionalities of potassium tantalate niobate deflectors enabled by the coexistence of pre-injected space charge and composition gradient

NASA Astrophysics Data System (ADS)

Zhu, Wenbin; Chao, Ju-Hung; Chen, Chang-Jiang; Campbell, Adrian L.; Henry, Michael G.; Yin, Stuart Shizhuo; Hoffman, Robert C.

2017-10-01

In most beam steering applications such as 3D printing and in vivo imaging, one of the essential challenges has been high-resolution high-speed multi-dimensional optical beam scanning. Although the pre-injected space charge controlled potassium tantalate niobate (KTN) deflectors can achieve speeds in the nanosecond regime, they deflect in only one dimension. In order to develop a high-resolution high-speed multi-dimensional KTN deflector, we studied the deflection behavior of KTN deflectors in the case of coexisting pre-injected space charge and composition gradient. We find that such coexistence can enable new functionalities of KTN crystal based electro-optic deflectors. When the direction of the composition gradient is parallel to the direction of the external electric field, the zero-deflection position can be shifted, which can reduce the internal electric field induced beam distortion, and thus enhance the resolution. When the direction of the composition gradient is perpendicular to the direction of the external electric field, two-dimensional beam scanning can be achieved by harnessing only one single piece of KTN crystal, which can result in a compact, high-speed two-dimensional deflector. Both theoretical analyses and experiments are conducted, which are consistent with each other. These new functionalities can expedite the usage of KTN deflection in many applications such as high-speed 3D printing, high-speed, high-resolution imaging, and free space broadband optical communication.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dempsey, Adam B.; Curran, Scott; Wagner, Robert M.

Gasoline compression ignition concepts with the majority of the fuel being introduced early in the cycle are known as partially premixed combustion (PPC). Previous research on single- and multi-cylinder engines has shown that PPC has the potential for high thermal efficiency with low NOx and soot emissions. A variety of fuel injection strategies has been proposed in the literature. These injection strategies aim to create a partially stratified charge to simultaneously reduce NOx and soot emissions while maintaining some level of control over the combustion process through the fuel delivery system. The impact of the direct injection strategy to createmore » a premixed charge of fuel and air has not previously been explored, and its impact on engine efficiency and emissions is not well understood. This paper explores the effect of sweeping the direct injected pilot timing from -91° to -324° ATDC, which is just after the exhaust valve closes for the engine used in this study. During the sweep, the pilot injection consistently contained 65% of the total fuel (based on command duration ratio), and the main injection timing was adjusted slightly to maintain combustion phasing near top dead center. A modern four cylinder, 1.9 L diesel engine with a variable geometry turbocharger, high pressure common rail injection system, wide included angle injectors, and variable swirl actuation was used in this study. The pistons were modified to an open bowl configuration suitable for highly premixed combustion modes. The stock diesel injection system was unmodified, and the gasoline fuel was doped with a lubricity additive to protect the high pressure fuel pump and the injectors. The study was conducted at a fixed speed/load condition of 2000 rpm and 4.0 bar brake mean effective pressure (BMEP). The pilot injection timing sweep was conducted at different intake manifold pressures, swirl levels, and fuel injection GTP-15-1067, Dempsey 2 pressures. The gasoline used in this study has relatively high fuel reactivity with a research octane number of 68. The results of this experimental campaign indicate that the highest brake thermal efficiency and lowest emissions are achieved simultaneously with the earliest pilot injection timings (i.e., during the intake stroke).« less

Use of Adaptive Injection Strategies to Increase the Full Load Limit of RCCI Operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, Reed; Ickes, Andrew; Wallner, Thomas

2015-01-01

Dual-fuel combustion using port-injection of low reactivity fuel combined with direct injection of a higher reactivity fuel, otherwise known as Reactivity Controlled Compression Ignition (RCCI), has been shown as a method to achieve low-temperature combustion with moderate peak pressure rise rates, low engine-out soot and NOx emissions, and high indicated thermal efficiency. A key requirement for extending to high-load operation is moderating the reactivity of the premixed charge prior to the diesel injection. One way to accomplish this is to use a very low reactivity fuel such as natural gas. In this work, experimental testing was conducted on a 13Lmore » multi-cylinder heavy-duty diesel engine modified to operate using RCCI combustion with port injection of natural gas and direct injection of diesel fuel. Engine testing was conducted at an engine speed of 1200 RPM over a wide variety of loads and injection conditions. The impact on dual-fuel engine performance and emissions with respect to varying the fuel injection parameters is quantified within this study. The injection strategies used in the work were found to affect the combustion process in similar ways to both conventional diesel combustion and RCCI combustion for phasing control and emissions performance. As the load is increased, the port fuel injection quantity was reduced to keep peak cylinder pressure and maximum pressure rise rate under the imposed limits. Overall, the peak load using the new injection strategy was shown to reach 22 bar BMEP with a peak brake thermal efficiency of 47.6%.« less

PSR Injection Line Upgrade

NASA Astrophysics Data System (ADS)

Blind, Barbara; Jason, Andrew J.

1997-05-01

We describe the new injection line to be implemented for the Los Alamos Proton Storage Ring in the change from a two-step process to direct H- injection. While obeying all geometrical constraints imposed by the existing structures, the new line has properties not found in the present injection line. In particular, it features decoupled transverse phase spaces downstream of the skew bend and a high degree of tunability of the beam at the injection foil. A comprehensive set of error studies has dictated the component tolerances imposed and has indicated the expected performance of the system.

Numerical investigation of CAI Combustion in the Opposed- Piston Engine with Direct and Indirect Water Injection

NASA Astrophysics Data System (ADS)

Pyszczek, R.; Mazuro, P.; Teodorczyk, A.

2016-09-01

This paper is focused on the CAI combustion control in a turbocharged 2-stroke Opposed-Piston (OP) engine. The barrel type OP engine arrangement is of particular interest for the authors because of its robust design, high mechanical efficiency and relatively easy incorporation of a Variable Compression Ratio (VCR). The other advantage of such design is that combustion chamber is formed between two moving pistons - there is no additional cylinder head to be cooled which directly results in an increased thermal efficiency. Furthermore, engine operation in a Controlled Auto-Ignition (CAI) mode at high compression ratios (CR) raises a possibility of reaching even higher efficiencies and very low emissions. In order to control CAI combustion such measures as VCR and water injection were considered for indirect ignition timing control. Numerical simulations of the scavenging and combustion processes were performed with the 3D CFD multipurpose AVL Fire solver. Numerous cases were calculated with different engine compression ratios and different amounts of directly and indirectly injected water. The influence of the VCR and water injection on the ignition timing and engine performance was determined and their application in the real engine was discussed.

Basic requirements of fuel-injection nozzles for quiescent combustion chambers

NASA Technical Reports Server (NTRS)

Spanogle, J A; Foster, H H

1931-01-01

This report presents test results obtained during an investigation of the performance of a single-cylinder, high-speed, compression-ignition test engine when using multiple-orifice fuel-injection valve nozzles in which the number and the direction of the orifices were varied independently.

Performance of a High-Speed Compression-Ignition Engine Using Multiple Orifice Fuel Injection Nozzles

NASA Technical Reports Server (NTRS)

Spanogle, J A; Foster, H H

1930-01-01

This report presents test results obtained at the Langley Memorial Aeronautical Laboratory of the National Advisory Committee for Aeronautics during an investigation to determine the relative performance of a single-cylinder, high-speed, compression-ignition engine when using fuel injection valve nozzles with different numbers, sizes, and directions of round orifices. A spring-loaded, automatic injection valve was used, centrally located at the top of a vertical disk-type combustion chamber formed between horizontally opposed inlet and exhaust valves of a 5 inch by 7 inch engine.

High North American Monsoon Lowermost Stratospheric Water Vapor: Signatures of Convective Injection from MLS and Other Satellite Measurements

NASA Astrophysics Data System (ADS)

Schwartz, M. J.; Santee, M. L.; Livesey, N. J.; Read, W. G.

2015-12-01

The summer North American monsoon anticyclone (NAMA) and the Asian monsoon anticyclone (AMA) enclose most of the highest 100 hPa and 83 hPa water vapor (H2O) mixing ratios in the 11-year Aura Microwave Limb Sounder record, both in terms of mean values and in high outliers. The highest NAMA H2O outliers in the central continental United States are almost certainly the result of direct, local injection of ice into the lower stratosphere (LS) by convection that overshoots the tropopause. However, the relative importance of these direct injections in supplying the bulk of the NAMA LS humidity anomaly compared to that of transport from convection on the tropical side of the anticyclone has not been conclusively determined. Large-scale circulation models have reproduced the high NAMA LS water vapor with tropical convection followed by advection and ascent, however the handling of convection in such models is generally a source of uncertainty. NAMA H2O at 100--83 hPa is close to saturation at the low tropopause temperatures on the tropical side of the anticylone, and cold anomalies above this convection have been shown to act as cold traps, leading to an anticorrelation between NAMA LS humidity and tropical convective intensity. In this work we use MLS and other satellite-based observations to investigate the importance of direct convective injection in supplying the high H2O anomalies within the NAMA LS anticyclone.

Low NOx, Lean Direct Wall Injection Combustor Concept Developed

NASA Technical Reports Server (NTRS)

Tacina, Robert R.; Wey, Changlie; Choi, Kyung J.

2003-01-01

The low-emissions combustor development at the NASA Glenn Research Center is directed toward advanced high-pressure aircraft gas turbine applications. The emphasis of this research is to reduce nitrogen oxides (NOx) at high-power conditions and to maintain carbon monoxide and unburned hydrocarbons at their current low levels at low-power conditions. Low-NOx combustors can be classified into rich burn and lean burn concepts. Lean burn combustors can be further classified into lean-premixed-prevaporized (LPP) and lean direct injection (LDI) combustors. In both concepts, all the combustor air, except for liner cooling flow, enters through the combustor dome so that the combustion occurs at the lowest possible flame temperature. The LPP concept has been shown to have the lowest NOx emissions, but for advanced high-pressure-ratio engines, the possibly of autoignition or flashback precludes its use. LDI differs from LPP in that the fuel is injected directly into the flame zone and, thus, does not have the potential for autoignition or flashback and should have greater stability. However, since it is not premixed and prevaporized, the key is good atomization and mixing of the fuel quickly and uniformly so that flame temperatures are low and NOx formation levels are comparable to those of LPP.

An update on blast furnace granular coal injection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, D.G.; Strayer, T.J.; Bouman, R.W.

1997-12-31

A blast furnace coal injection system has been constructed and is being used on the furnace at the Burns Harbor Division of Bethlehem Steel. The injection system was designed to deliver both granular (coarse) and pulverized (fine) coal. Construction was completed on schedule in early 1995. Coal injection rates on the two Burns Harbor furnaces were increased throughout 1995 and was over 200 lbs/ton on C furnace in September. The injection rate on C furnace reached 270 lbs/ton by mid-1996. A comparison of high volatile and low volatile coals as injectants shows that low volatile coal replaces more coke andmore » results in a better blast furnace operation. The replacement ratio with low volatile coal is 0.96 lbs coke per pound of coal. A major conclusion of the work to date is that granular coal injection performs very well in large blast furnaces. Future testing will include a processed sub-bituminous coal, a high ash coal and a direct comparison of granular versus pulverized coal injection.« less

Semiconductor laser technology for remote sensing experiments

NASA Technical Reports Server (NTRS)

Katz, Joseph

1988-01-01

Semiconductor injection lasers are required for implementing virtually all spaceborne remote sensing systems. Their main advantages are high reliability and efficiency, and their main roles are envisioned in pumping and injection locking of solid state lasers. In some shorter range applications they may even be utilized directly as the sources.

Collective properties of injection-induced earthquake sequences: 1. Model description and directivity bias

NASA Astrophysics Data System (ADS)

Dempsey, David; Suckale, Jenny

2016-05-01

Induced seismicity is of increasing concern for oil and gas, geothermal, and carbon sequestration operations, with several M > 5 events triggered in recent years. Modeling plays an important role in understanding the causes of this seismicity and in constraining seismic hazard. Here we study the collective properties of induced earthquake sequences and the physics underpinning them. In this first paper of a two-part series, we focus on the directivity ratio, which quantifies whether fault rupture is dominated by one (unilateral) or two (bilateral) propagating fronts. In a second paper, we focus on the spatiotemporal and magnitude-frequency distributions of induced seismicity. We develop a model that couples a fracture mechanics description of 1-D fault rupture with fractal stress heterogeneity and the evolving pore pressure distribution around an injection well that triggers earthquakes. The extent of fault rupture is calculated from the equations of motion for two tips of an expanding crack centered at the earthquake hypocenter. Under tectonic loading conditions, our model exhibits a preference for unilateral rupture and a normal distribution of hypocenter locations, two features that are consistent with seismological observations. On the other hand, catalogs of induced events when injection occurs directly onto a fault exhibit a bias toward ruptures that propagate toward the injection well. This bias is due to relatively favorable conditions for rupture that exist within the high-pressure plume. The strength of the directivity bias depends on a number of factors including the style of pressure buildup, the proximity of the fault to failure and event magnitude. For injection off a fault that triggers earthquakes, the modeled directivity bias is small and may be too weak for practical detection. For two hypothetical injection scenarios, we estimate the number of earthquake observations required to detect directivity bias.

Injection characteristics study of high-pressure direct injector for Compressed Natural Gas (CNG) using experimental and analytical method

NASA Astrophysics Data System (ADS)

Taha, Z.; Rahim, MF Abdul; Mamat, R.

2017-10-01

The injection characteristics of direct injector affect the mixture formation and combustion processes. In addition, the injector is converted from gasoline operation for CNG application. Thus measurement of CNG direct injector mass flow rate was done by independently tested a single injector on a test bench. The first case investigated the effect of CNG injection pressure and the second case evaluate the effect of pulse-width of injection duration. An analytical model was also developed to predict the mass flow rate of the injector. The injector was operated in a choked condition in both the experiments and simulation studies. In case 1, it was shown that mass flow rate through the injector is affected by injection pressure linearly. Based on the tested injection pressure of 20 bar to 60 bar, the resultant mass flow rate are in the range of 0.4 g/s to 1.2 g/s which are met with theoretical flow rate required by the engine. However, in Case 2, it was demonstrated that the average mass flow rate at short injection durations is lower than recorded in Case 1. At injection pressure of 50 bar, the average mass flow rate for Case 2 and Case 1 are 0.7 g/s and 1.1 g/s respectively. Also, the measured mass flow rate at short injection duration showing a fluctuating data in the range of 0.2 g/s - 1.3 g/s without any noticeable trends. The injector model able to predict the trend of the mass flow rate at different injection pressure but unable to track the fluctuating trend at short injection duration.

Effect of Premixed Fuel Preparation for Partially Premixed Combustion with a Low Octane Gasoline on a Light-Duty Multi-Cylinder Compression Ignition Engine

DOE PAGES

Dempsey, Adam B.; Curran, Scott; Wagner, Robert M.; ...

2015-05-12

Gasoline compression ignition concepts with the majority of the fuel being introduced early in the cycle are known as partially premixed combustion (PPC). Previous research on single- and multi-cylinder engines has shown that PPC has the potential for high thermal efficiency with low NOx and soot emissions. A variety of fuel injection strategies has been proposed in the literature. These injection strategies aim to create a partially stratified charge to simultaneously reduce NOx and soot emissions while maintaining some level of control over the combustion process through the fuel delivery system. The impact of the direct injection strategy to createmore » a premixed charge of fuel and air has not previously been explored, and its impact on engine efficiency and emissions is not well understood. This paper explores the effect of sweeping the direct injected pilot timing from -91° to -324° ATDC, which is just after the exhaust valve closes for the engine used in this study. During the sweep, the pilot injection consistently contained 65% of the total fuel (based on command duration ratio), and the main injection timing was adjusted slightly to maintain combustion phasing near top dead center. A modern four cylinder, 1.9 L diesel engine with a variable geometry turbocharger, high pressure common rail injection system, wide included angle injectors, and variable swirl actuation was used in this study. The pistons were modified to an open bowl configuration suitable for highly premixed combustion modes. The stock diesel injection system was unmodified, and the gasoline fuel was doped with a lubricity additive to protect the high pressure fuel pump and the injectors. The study was conducted at a fixed speed/load condition of 2000 rpm and 4.0 bar brake mean effective pressure (BMEP). The pilot injection timing sweep was conducted at different intake manifold pressures, swirl levels, and fuel injection GTP-15-1067, Dempsey 2 pressures. The gasoline used in this study has relatively high fuel reactivity with a research octane number of 68. The results of this experimental campaign indicate that the highest brake thermal efficiency and lowest emissions are achieved simultaneously with the earliest pilot injection timings (i.e., during the intake stroke).« less

A qualitative view of cryogenic fluid injection into high speed flows

NASA Technical Reports Server (NTRS)

Hendricks, R. C.; Schlumberger, J.; Proctor, M.

1991-01-01

The injection of supercritical pressure, subcritical temperature fluids, into a 2-D, ambient, static temperature and static pressure supersonic tunnel and free jet supersonic nitrogen flow field was observed. Observed patterns with fluid air were the same as those observed for fluid nitrogen injected into the tunnel at 90 deg to the supersonic flow. The nominal injection pressure was of 6.9 MPa and tunnel Mach number was 2.7. When injected directly into and opposing the tunnel exhaust flow, the observed patterns with fluid air were similar to those observed for fluid nitrogen but appeared more diffusive. Cryogenic injection creates a high density region within the bow shock wake but the standoff distance remains unchanged from the gaseous value. However, as the temperature reaches a critical value, the shock faded and advanced into the supersonic stream. For both fluids, nitrogen and air, the phenomena was completely reversible.

High efficiency single transverse mode photonic band crystal lasers with low vertical divergence

NASA Astrophysics Data System (ADS)

Zhao, Shaoyu; Qu, Hongwei; Liu, Yun; Li, Lunhua; Chen, Yang; Zhou, Xuyan; Lin, Yuzhe; Liu, Anjin; Qi, Aiyi; Zheng, Wanhua

2016-10-01

High efficiency 980 nm longitudinal photonic band crystal (PBC) edge emitting laser diodes are designed and fabricated. The calculated results show that eight periods of Al0.1Ga0.9As and Al0.25Ga0.75As layer pairs can reduce the vertical far field divergence to 10.6° full width at half maximum (FWHM). The broad area (BA) lasers show a very high internal quantum efficiency ηi of 98% and low internal loss αi of 1.92 cm-1. Ridge waveguide (RW) lasers with 3 mm cavity length and 5um strip width provide 430 mW stable single transverse mode output at 500 mA injection current with power conversion efficiency (PCE) of 47% under continuous wave (CW) mode. A maximum PCE of 50% is obtained at the 300 mA injection current. A very low vertical far field divergence of 9.4° is obtained at 100 mA injection. At 500 mA injection, the vertical far field divergence increases to 11°, the beam quality factors M2 values are 1.707 in vertical direction and 1.769 in lateral direction.

Injectable Anisotropic Nanocomposite Hydrogels Direct in Situ Growth and Alignment of Myotubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

De France, Kevin J.; Yager, Kevin G.; Chan, Katelyn J. W.

Here, while injectable in situ cross-linking hydrogels have attracted increasing attention as minimally invasive tissue scaffolds and controlled delivery systems, their inherently disorganized and isotropic network structure limits their utility in engineering oriented biological tissues. Traditional methods to prepare anisotropic hydrogels are not easily translatable to injectable systems given the need for external equipment to direct anisotropic gel fabrication and/or the required use of temperatures or solvents incompatible with biological systems. Herein, we report a new class of injectable nanocomposite hydrogels based on hydrazone cross-linked poly(oligoethylene glycol methacrylate) and magnetically aligned cellulose nanocrystals (CNCs) capable of encapsulating skeletal muscle myoblastsmore » and promoting their differentiation into highly oriented myotubes in situ. CNC alignment occurs on the same time scale as network gelation and remains fixed after the removal of the magnetic field, enabling concurrent CNC orientation and hydrogel injection. The aligned hydrogels show mechanical and swelling profiles that can be rationally modulated by the degree of CNC alignment and can direct myotube alignment both in two- and three-dimensions following coinjection of the myoblasts with the gel precursor components. As such, these hydrogels represent a critical advancement in anisotropic biomimetic scaffolds that can be generated noninvasively in vivo following simple injection.« less

Injectable Anisotropic Nanocomposite Hydrogels Direct in Situ Growth and Alignment of Myotubes

DOE PAGES

De France, Kevin J.; Yager, Kevin G.; Chan, Katelyn J. W.; ...

2017-09-28

Here, while injectable in situ cross-linking hydrogels have attracted increasing attention as minimally invasive tissue scaffolds and controlled delivery systems, their inherently disorganized and isotropic network structure limits their utility in engineering oriented biological tissues. Traditional methods to prepare anisotropic hydrogels are not easily translatable to injectable systems given the need for external equipment to direct anisotropic gel fabrication and/or the required use of temperatures or solvents incompatible with biological systems. Herein, we report a new class of injectable nanocomposite hydrogels based on hydrazone cross-linked poly(oligoethylene glycol methacrylate) and magnetically aligned cellulose nanocrystals (CNCs) capable of encapsulating skeletal muscle myoblastsmore » and promoting their differentiation into highly oriented myotubes in situ. CNC alignment occurs on the same time scale as network gelation and remains fixed after the removal of the magnetic field, enabling concurrent CNC orientation and hydrogel injection. The aligned hydrogels show mechanical and swelling profiles that can be rationally modulated by the degree of CNC alignment and can direct myotube alignment both in two- and three-dimensions following coinjection of the myoblasts with the gel precursor components. As such, these hydrogels represent a critical advancement in anisotropic biomimetic scaffolds that can be generated noninvasively in vivo following simple injection.« less

Modeling of lithium granule injection in NSTX using M3D-C1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fil, A.; Kolemen, E.; Ferraro, N.

In this paper, we present simulations of pedestal control by lithium granule injection (LGI) in NSTX. A model for small granule ablation has been implemented in the M3D-C1 code (Jardin et al 2012 Comput. Sci. Discovery 5 014002), allowing the simulation of realistic lithium granule injections. 2D and 3D simulations of Li injections in NSTX H-mode plasmas are performed and the effect of granule size, injection angle and velocity on the pedestal gradient increase is studied. The amplitude of the local pressure perturbation caused by the granules is found to be highly dependent on the solid granule size. Adjusting themore » granule injection velocity allows one to inject more particles at the pedestal top. 3D simulations show the destabilization of high order MHD modes whose amplitude is directly linked to the localized pressure perturbation, which is found to depend on the toroidal localization of the granule density source.« less

Modeling of lithium granule injection in NSTX using M3D-C1

DOE PAGES

Fil, A.; Kolemen, E.; Ferraro, N.; ...

2017-04-06

In this paper, we present simulations of pedestal control by lithium granule injection (LGI) in NSTX. A model for small granule ablation has been implemented in the M3D-C1 code (Jardin et al 2012 Comput. Sci. Discovery 5 014002), allowing the simulation of realistic lithium granule injections. 2D and 3D simulations of Li injections in NSTX H-mode plasmas are performed and the effect of granule size, injection angle and velocity on the pedestal gradient increase is studied. The amplitude of the local pressure perturbation caused by the granules is found to be highly dependent on the solid granule size. Adjusting themore » granule injection velocity allows one to inject more particles at the pedestal top. 3D simulations show the destabilization of high order MHD modes whose amplitude is directly linked to the localized pressure perturbation, which is found to depend on the toroidal localization of the granule density source.« less

On the nature of directed behavior to drug-associated light cues in rhesus monkeys (Macaca mulatta).

PubMed

Reilly, Mark P; Berndt, Sonja I; Woods, James H

2016-11-01

The present study investigated the role of drug-paired stimuli in controlling the behavior of rhesus monkeys. Systematic observations were made with nine monkeys who had a history of drug self-administration; they had been lever pressing to produce intravenous infusions of various drugs. These observations revealed that the stimulus light co-occurring with drug infusion produced robust and cue-directed behavior such as orienting, touching and biting. Experiment 1 showed that this light-directed behavior would occur in naïve monkeys exposed to a Pavlovian pairing procedure. Four monkeys were given response-independent injections of cocaine. In two monkeys, a red light preceded cocaine injections by 5 s, and a green light co-occurred with the 5-s cocaine injections. In the other two monkeys, the light presentations and cocaine injections occurred independently. Light-directed behavior occurred in all four monkeys within the first couple of trials and at high levels but decreased across sessions. The cocaine-paired stimulus maintained behavior longer and at higher levels than the uncorrelated stimuli. Furthermore, light-directed behavior was not maintained when cocaine was replaced with saline. Light-directed behavior did not occur in the absence of the lights. When these monkeys were subsequently trained to lever press for cocaine, light-directed behavior increased to levels higher than previously observed. Behavior directed towards drug-paired stimuli is robust, reliable and multiply determined; the mechanisms underlying this activity likely include Pavlovian conditioning, stimulus novelty, habituation and operant conditioning.

Quantification of polychlorinated dibenzo-p-dioxins and dibenzofurans by direct injection of sample extract into the comprehensive multidimensional gas chromatograph/high-resolution time-of-flight mass spectrometer.

PubMed

Shunji, Hashimoto; Yoshikatsu, Takazawa; Akihiro, Fushimi; Hiroyasu, Ito; Kiyoshi, Tanabe; Yasuyuki, Shibata; Masa-aki, Ubukata; Akihiko, Kusai; Kazuo, Tanaka; Hideyuki, Otsuka; Katsunori, Anezaki

2008-01-18

Polychlorinated dibenzo-p-dioxins and dibenzofurans in crude extracts of fly ash and flue gas from municipal waste incinerators were quantified using a comprehensive multidimensional gas chromatograph (GC x GC) coupled to a high-resolution time-of-flight mass spectrometer (HR-TOFMS). For identification and quantification, we developed our own program to prepare 3D chromatograms of selected mass numbers from the data of the GC x GC/HR-TOFMS. Isolation of all congeners with a TCDD toxic equivalency factor from the other isomers by only one injection was confirmed. The instrumental detection limit of TCDD on the GC x GC/HR-TOFMS was 0.9 pg by the relative calibration method. Quantification of these substances in the crude extracts was achieved by direct injection to the GC x GC/HR-TOFMS. The results agree with the values obtained using a generic gas chromatography/high-resolution mass spectrometry (GC/HRMS) system. It was confirmed that measurement by high-resolution TOFMS and GC x GC effectively reduces interference from other chemicals.

Vacuum-integrated electrospray deposition for highly reliable polymer thin film.

PubMed

Park, Soohyung; Lee, Younjoo; Yi, Yeonjin

2012-10-01

Vacuum electrospray deposition (ESD) equipment was designed to prepare polymer thin films. The polymer solution can be injected directly into vacuum system through multi-stage pumping line, so that the solvent residues and ambient contaminants are highly reduced. To test the performance of ESD system, we fabricated organic photovoltaic cells (OPVCs) by injecting polymer solution directly onto the substrate inside a high vacuum chamber. The OPVC fabricated has the structure of Al∕P3HT:PCBM∕PEDOT:PSS∕ITO and was optimized by varying the speed of solution injection and concentration of the solution. The power conversion efficiency (PCE) of the optimized OPVC is 3.14% under AM 1.5G irradiation without any buffer layer at the cathode side. To test the advantages of the vacuum ESD, we exposed the device to atmosphere between the deposition steps of the active layer and cathode. This showed that the PCE of the vacuum processed device is 24% higher than that of the air exposed device and confirms the advantages of the vacuum prepared polymer film for high performance devices.

Direct electron injection into an oxide insulator using a cathode buffer layer

PubMed Central

Lee, Eungkyu; Lee, Jinwon; Kim, Ji-Hoon; Lim, Keon-Hee; Seok Byun, Jun; Ko, Jieun; Dong Kim, Young; Park, Yongsup; Kim, Youn Sang

2015-01-01

Injecting charge carriers into the mobile bands of an inorganic oxide insulator (for example, SiO2, HfO2) is a highly complicated task, or even impossible without external energy sources such as photons. This is because oxide insulators exhibit very low electron affinity and high ionization energy levels. Here we show that a ZnO layer acting as a cathode buffer layer permits direct electron injection into the conduction bands of various oxide insulators (for example, SiO2, Ta2O5, HfO2, Al2O3) from a metal cathode. Studies of current–voltage characteristics reveal that the current ohmically passes through the ZnO/oxide-insulator interface. Our findings suggests that the oxide insulators could be used for simply fabricated, transparent and highly stable electronic valves. With this strategy, we demonstrate an electrostatic discharging diode that uses 100-nm SiO2 as an active layer exhibiting an on/off ratio of ∼107, and protects the ZnO thin-film transistors from high electrical stresses. PMID:25864642

Temperature field measurement research in high-speed diesel engine using laser induced fluorescence technology

NASA Astrophysics Data System (ADS)

Liu, Yongfeng; Zhang, You-tong; Gou, Chenhua; Tian, Hongsen

2008-12-01

Temperature laser- induced- fluorescence (LIF) 2-D imaging measurements using a new multi-spectral detection strategy are reported for high pressure flames in high-speed diesel engine. Schematic of the experimental set-up is outlined and the experimental data on the diesel engine is summarized. Experiment injection system is a third generation Bosch high-pressure common rail featuring a maximum pressure of 160 MPa. The injector is equipped with a six-hole nozzle, where each hole has a diameter of 0.124 mm. and slightly offset (by 1.0 mm) to the center of the cylinder axis to allow a better cooling of the narrow bridge between the exhaust valves. The measurement system includes a blower, which supplied the intake flow rate, and a prototype single-valve direct injection diesel engine head modified to lay down the swirled-type injector. 14-bit digital CCD cameras are employed to achieve a greater level of accuracy in comparison to the results of previous measurements. The temperature field spatial distributions in the cylinder for different crank angle degrees are carried out in a single direct-injection diesel engine.

Development of a 100-W, single-frequency Nd:YAG laser for large-scale cryogenic gravitational wave telescope

NASA Astrophysics Data System (ADS)

Takeno, K.; Ozeki, T.; Moriwaki, S.; Mio, N.

2006-03-01

We have built a 100-W injection-locked Nd:YAG laser for a Japanese next generation gravitational wave detector. A 2-W master laser was directly injected to a high-power slave laser, which led to coherent radiation of 100 W at 1064 nm.

Evaluation of a direct injection nebulizer interface for flow injection analysis and high performance liquid chromatography with inductively coupled plasma-atomic emission spectroscopic detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, K.E.

A direct injection nebulizer (DIN) was designed, developed, and evaluated to determine its potential utilization as an effective interface for flow injection analysis (FIA) and high performance liquid chromatography (HPLC) coupled with inductively coupled plasma-atomic emission spectroscopic detection. The analytical figures of merit for the DIN when used as an interface for FIA-ICP-AES were found to be comparable to or better than those obtained with conventional pneumatic nebulization in terms of limits of detection (LODs), reproducibility, linearity, and interelement effects. Stable plasma operation was maintained for the DIN sample introduction of a variety of pure organic solvents, including acetonitrile, methanol,more » methylisobutylketone, and pyridine. The HPLC-DIN-ICP-AES facility was specifically applied for the speciation of inorganic and organometallic species contained in synthetic mixtures, vanilla extracts, and a variety of energy-related materials, such as shale oil process water, coal extracts, shale oil, crude oil, and an SRC II. Suggestions for future research are also considered. 227 refs., 44 figs., 15 tabs.« less

Premixed direct injection nozzle for highly reactive fuels

DOEpatents

Ziminsky, Willy Steve; Johnson, Thomas Edward; Lacy, Benjamin Paul; York, William David; Uhm, Jong Ho; Zuo, Baifang

2013-09-24

A fuel/air mixing tube for use in a fuel/air mixing tube bundle is provided. The fuel/air mixing tube includes an outer tube wall extending axially along a tube axis between an inlet end and an exit end, the outer tube wall having a thickness extending between an inner tube surface having a inner diameter and an outer tube surface having an outer tube diameter. The tube further includes at least one fuel injection hole having a fuel injection hole diameter extending through the outer tube wall, the fuel injection hole having an injection angle relative to the tube axis. The invention provides good fuel air mixing with low combustion generated NOx and low flow pressure loss translating to a high gas turbine efficiency, that is durable, and resistant to flame holding and flash back.

Turbine vane leading edge gas film cooling with spanwise angled coolant holes

NASA Technical Reports Server (NTRS)

Hanus, G. J.; Lecuyer, M. R.

1976-01-01

An experimental film cooling study was conducted on a 3x size model turbine vane. Injection at the leading edge was from a single row of holes angled in a spanwise direction for two configurations of holes at 18 or 35 deg to the surface. The reduction in the local Stanton number for injection at a coolant-to-mainstream density ratio of 2.18 was calculated from heat flux measurements downstream of injection. Results indicate that optimum cooling occurs near a coolant-to-mainstream velocity ratio of 0.5. Shallow injection angles appear to be most beneficial when injecting into a highly accelerated mainstream.

Experimental feasibility study of radial injection cooling of three-pad radial air foil bearings

NASA Astrophysics Data System (ADS)

Shrestha, Suman K.

Air foil bearings use ambient air as a lubricant allowing environment-friendly operation. When they are designed, installed, and operated properly, air foil bearings are very cost effective and reliable solution to oil-free turbomachinery. Because air is used as a lubricant, there are no mechanical contacts between the rotor and bearings and when the rotor is lifted off the bearing, near frictionless quiet operation is possible. However, due to the high speed operation, thermal management is one of the very important design factors to consider. Most widely accepted practice of the cooling method is axial cooling, which uses cooling air passing through heat exchange channels formed underneath the bearing pad. Advantage is no hardware modification to implement the axial cooling because elastic foundation structure of foil bearing serves as a heat exchange channels. Disadvantage is axial temperature gradient on the journal shaft and bearing. This work presents the experimental feasibility study of alternative cooling method using radial injection of cooling air directly on the rotor shaft. The injection speeds, number of nozzles, location of nozzles, total air flow rate are important factors determining the effectiveness of the radial injection cooling method. Effectiveness of the radial injection cooling was compared with traditional axial cooling method. A previously constructed test rig was modified to accommodate a new motor with higher torque and radial injection cooling. The radial injection cooling utilizes the direct air injection to the inlet region of air film from three locations at 120° from one another with each location having three axially separated holes. In axial cooling, a certain axial pressure gradient is applied across the bearing to induce axial cooling air through bump foil channels. For the comparison of the two methods, the same amount of cooling air flow rate was used for both axial cooling and radial injection. Cooling air flow rate was referenced to the rotor surface speed for radial injection cooling. The mass flow rates for the radial injection were 0.032, 0.0432, 0.054 and 0.068 Kg/min, which result in average injection speed of 150, 200, 250 and 300% of rotor surface speed. Several thermocouples were attached at various circumferential directions of the bearing sleeve, two plenums, bearing holder and ball bearing housings to collect the temperature data of the bearing at 30krpm under 10lb of load. Both axial cooling and radial injection are effective cooling mechanism and effectiveness of both cooling methods is directly proportional to the total mass flow rates. However, axial cooling is slightly more efficient in controlling the average temperature of the bearing sleeve, but results in higher thermal gradient of the shaft along the axial direction and also higher thermal gradient of the bearing sleeve along the circumferential direction compared to the radial injection cooling. The smaller thermal gradient of the radial injection cooling is due to the direct cooling effect of the shaft by impinging jets. While the axial cooling has an effect on only the bearing, the radial injection has a cooling effect on both the bearing sleeve and shaft. It is considered the radial injection cooling needs to be further optimized in terms of number of injection holes and their locations.

Accurate determination of sulfur in gasoline and related fuel samples using isotope dilution ICP-MS with direct sample injection and microwave-assisted digestion.

PubMed

Heilmann, Jens; Boulyga, Sergei F; Heumann, Klaus G

2004-09-01

Inductively coupled plasma isotope-dilution mass spectrometry (ICP-IDMS) with direct injection of isotope-diluted samples into the plasma, using a direct injection high-efficiency nebulizer (DIHEN), was applied for accurate sulfur determinations in sulfur-free premium gasoline, gas oil, diesel fuel, and heating oil. For direct injection a micro-emulsion consisting of the corresponding organic sample and an aqueous 34S-enriched spike solution with additions of tetrahydronaphthalene and Triton X-100, was prepared. The ICP-MS parameters were optimized with respect to high sulfur ion intensities, low mass-bias values, and high precision of 32S/34S ratio measurements. For validation of the DIHEN-ICP-IDMS method two certified gas oil reference materials (BCR 107 and BCR 672) were analyzed. For comparison a wet-chemical ICP-IDMS method was applied with microwave-assisted digestion using decomposition of samples in a closed quartz vessel inserted into a normal microwave system. The results from both ICP-IDMS methods agree well with the certified values of the reference materials and also with each other for analyses of other samples. However, the standard deviation of DIHEN-ICP-IDMS was about a factor of two higher (5-6% RSD at concentration levels above 100 mircog g(-1)) compared with those of wet-chemical ICP-IDMS, mainly due to inhomogeneities of the micro-emulsion, which causes additional plasma instabilities. Detection limits of 4 and 18 microg g(-1) were obtained for ICP-IDMS in connection with microwave-assisted digestion and DIHEN-ICP-IDMS, respectively, with a sulfur background of the used Milli-Q water as the main limiting factor for both methods.

Analysis of selected antibiotics in surface freshwater and seawater using direct injection in liquid chromatography electrospray ionization tandem mass spectrometry.

PubMed

Bayen, Stéphane; Yi, Xinzhu; Segovia, Elvagris; Zhou, Zhi; Kelly, Barry C

2014-04-18

Emerging contaminants such as antibiotics have received recent attention as they have been detected in natural waters and health concerns over potential antibiotic resistance. With the purpose to investigate fast and high-throughput analysis, and eventually the continuous on-line analysis of emerging contaminants, this study presents results on the analysis of seven selected antibiotics (sulfadiazine, sulfamethazine, sulfamerazine, sulfamethoxazole, chloramphenicol, lincomycin, tylosin) in surface freshwater and seawater using direct injection of a small sample volume (20μL) in liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Notably, direct injection of seawater in the LC-ESI-MS/MS was made possible on account of the post-column switch on the system, which allows diversion of salt-containing solutions flushed out of the column to the waste. Mean recoveries based on the isotope dilution method average 95±14% and 96±28% amongst the compounds for spiked freshwater and seawater, respectively. Linearity across six spiking levels was assessed and the response was linear (r(2)>0.99) for all compounds. Direct injection concentrations were compared for real samples to those obtained with the conventional SPE-based analysis and both techniques concurs on the presence/absence and levels of the compounds in real samples. These results suggest direct injection is a reliable method to detect antibiotics in both freshwater and seawater. Method detection limits for the direct injection technique (37pg/L to 226ng/L in freshwater, and from 16pg/to 26ng/L in seawater) are sufficient for a number of environmental applications, for example the fast screening of water samples for ecological risk assessments. In the present study of real samples, this new method allowed for example the positive detection of some compounds (e.g. lincomycin) down to the sub ng/L range. The direct injection method appears to be relatively cheaper and faster, requires a smaller sample size, and is more robust to equipment cross-contamination as compared to the conventional SPE-based method. Copyright © 2014 Elsevier B.V. All rights reserved.

An apparatus for in situ x-ray scattering measurements during polymer injection molding.

PubMed

Rendon, Stanley; Fang, Jun; Burghardt, Wesley R; Bubeck, Robert A

2009-04-01

We report a novel instrument for synchrotron-based in situ x-ray scattering measurements during injection molding processing. It allows direct, real-time monitoring of molecular-scale structural evolution in polymer materials undergoing a complex processing operation. The instrument is based on a laboratory-scale injection molding machine, and employs customized mold tools designed to allow x-ray access during mold filling and subsequent solidification, while providing sufficient robustness to withstand high injection pressures. The use of high energy, high flux synchrotron radiation, and a fast detector allows sufficiently rapid data acquisition to resolve time-dependent orientation dynamics in this transient process. Simultaneous monitoring of temperature and pressure signals allows transient scattering data to be referenced to various stages of the injection molding cycle. Representative data on a commercial liquid crystalline polymer, Vectra(R) B950, are presented to demonstrate the features of this apparatus; however, it may find application in a wide range of polymeric materials such as nanocomposites, semicrystalline polymers and fiber-reinforced thermoplastics.

Injectable 3-D Fabrication of Medical Electronics at the Target Biological Tissues

NASA Astrophysics Data System (ADS)

Jin, Chao; Zhang, Jie; Li, Xiaokang; Yang, Xueyao; Li, Jingjing; Liu, Jing

2013-12-01

Conventional transplantable biomedical devices generally request sophisticated surgery which however often causes big trauma and serious pain to the patients. Here, we show an alternative way of directly making three-dimensional (3-D) medical electronics inside the biological body through sequential injections of biocompatible packaging material and liquid metal ink. As the most typical electronics, a variety of medical electrodes with different embedded structures were demonstrated to be easily formed at the target tissues. Conceptual in vitro experiments provide strong evidences for the excellent performances of the injectable electrodes. Further in vivo animal experiments disclosed that the formed electrode could serve as both highly efficient ECG (Electrocardiograph) electrode and stimulator electrode. These findings clarified the unique features and practicability of the liquid metal based injectable 3-D fabrication of medical electronics. The present strategy opens the way for directly manufacturing electrophysiological sensors or therapeutic devices in situ via a truly minimally invasive approach.

Brittle Materials Design, High Temperature Gas Turbine

DTIC Science & Technology

1975-04-01

was directed toward fabricating flaw- free one-piece first stage stators using a silicon metal powder injection molding composition yielding reaction...process was used because this composition utilizes thermoset polymers which cannot be handled on available injection molding equipment. Silicon...molded of several compositions incorporating slight variations. Some of the components molded had completely filled the die cavity and appeared

Effects of Advanced Fuel Injection Strategies on DI Diesel Emissions

DTIC Science & Technology

2001-06-19

Skeletal mechanism for NO chemistry in Diesel engines ," SAE Paper 981450. 2) Duffy, K. P. and Mellor, A. M. (1998), "jadf;lkajdf," SAE Paper. 3) Lavoie...pressure for this zone are the start of combustion, stoichiometric flame temperature (Tý.,) and pressure. The NO chemistry is based on a skeletal mechanism ...emissions from a 2.2L high speed direct injection (HSDI) Diesel engine [2]. Model Formulation for Single Injections: The model is based on the assumption

Observations of waves artificially stimulated by an electron beam inside a region with auroral precipitation

NASA Technical Reports Server (NTRS)

Grandal, B.; Troim, J.; Maehlum, B.; Holtet, J. A.; Pran, B.

1980-01-01

Observations of waves stimulated by artificial injection inside an auroral arc by an electron accelerator mounted on the POLAR 5 sounding rocket are presented. The accelerator produced a pulsed electron beam with currents up to 130 mA and energies up to 10 keV; emissions after the end of beam injection were generated by perturbations in the ambient plasma near the accelerator during beam injection. These emissions were independent of the electron beam direction along the geomagnetic field. The high frequency emission observed after beam injection correlated with the passage through an auroral arc; the low frequency emissions after beam injection were concentrated in two bands below the lower hybrid frequency.

Prevalence and correlates of crack-cocaine injection among young injection drug users in the United States, 1997-1999.

PubMed

Santibanez, Scott S; Garfein, Richard S; Swartzendruber, Andrea; Kerndt, Peter R; Morse, Edward; Ompad, Danielle; Strathdee, Steffanie; Williams, Ian T; Friedman, Samuel R; Ouellet, Lawrence J

2005-03-07

We estimated prevalence and identified correlates of crack-cocaine injection among young injection drug users in the United States. We analyzed data from the second Collaborative Injection Drug Users Study (CIDUS II), a 1997-1999 cohort study of 18-30-year-old, street-recruited injection drug users from six US cities. Crack-cocaine injection was reported by 329 (15%) of 2198 participants. Prevalence varied considerably by site (range, 1.5-28.0%). No participants injected only crack-cocaine. At four sites where crack-cocaine injection prevalence was greater than 10%, recent (past 6 months) crack-cocaine injection was correlated with recent daily injection and sharing of syringes, equipment, and drug solution. Lifetime crack-cocaine injection was correlated with using shooting galleries, initiating others into drug injection, and having serologic evidence of hepatitis B virus and hepatitis C virus infection. Crack-cocaine injection may be a marker for high-risk behaviors that can be used to direct efforts to prevent HIV and other blood-borne viral infections.

The direct injection of intense ion beams from a high field electron cyclotron resonance ion source into a radio frequency quadrupole

NASA Astrophysics Data System (ADS)

Rodrigues, G.; Becker, R.; Hamm, R. W.; Baskaran, R.; Kanjilal, D.; Roy, A.

2014-02-01

The ion current achievable from high intensity ECR sources for highly charged ions is limited by the high space charge. This makes classical extraction systems for the transport and subsequent matching to a radio frequency quadrupole (RFQ) accelerator less efficient. The direct plasma injection (DPI) method developed originally for the laser ion source avoids these problems and uses the combined focusing of the gap between the ion source and the RFQ vanes (or rods) and the focusing of the rf fields from the RFQ penetrating into this gap. For high performance ECR sources that use superconducting solenoids, the stray magnetic field of the source in addition to the DPI scheme provides focusing against the space charge blow-up of the beam. A combined extraction/matching system has been designed for a high performance ECR ion source injecting into an RFQ, allowing a total beam current of 10 mA from the ion source for the production of highly charged 238U40+ (1.33 mA) to be injected at an ion source voltage of 60 kV. In this design, the features of IGUN have been used to take into account the rf-focusing of an RFQ channel (without modulation), the electrostatic field between ion source extraction and the RFQ vanes, the magnetic stray field of the ECR superconducting solenoid, and the defocusing space charge of an ion beam. The stray magnetic field is shown to be critical in the case of a matched beam.

The direct injection of intense ion beams from a high field electron cyclotron resonance ion source into a radio frequency quadrupole.

PubMed

Rodrigues, G; Becker, R; Hamm, R W; Baskaran, R; Kanjilal, D; Roy, A

2014-02-01

The ion current achievable from high intensity ECR sources for highly charged ions is limited by the high space charge. This makes classical extraction systems for the transport and subsequent matching to a radio frequency quadrupole (RFQ) accelerator less efficient. The direct plasma injection (DPI) method developed originally for the laser ion source avoids these problems and uses the combined focusing of the gap between the ion source and the RFQ vanes (or rods) and the focusing of the rf fields from the RFQ penetrating into this gap. For high performance ECR sources that use superconducting solenoids, the stray magnetic field of the source in addition to the DPI scheme provides focusing against the space charge blow-up of the beam. A combined extraction/matching system has been designed for a high performance ECR ion source injecting into an RFQ, allowing a total beam current of 10 mA from the ion source for the production of highly charged (238)U(40+) (1.33 mA) to be injected at an ion source voltage of 60 kV. In this design, the features of IGUN have been used to take into account the rf-focusing of an RFQ channel (without modulation), the electrostatic field between ion source extraction and the RFQ vanes, the magnetic stray field of the ECR superconducting solenoid, and the defocusing space charge of an ion beam. The stray magnetic field is shown to be critical in the case of a matched beam.

Reaction-space analysis of homogeneous charge compression ignition combustion with varying levels of fuel stratification under positive and negative valve overlap conditions

DOE PAGES

Kodavasal, Janardhan; Lavoie, George A.; Assanis, Dennis N.; ...

2015-10-26

Full-cycle computational fluid dynamics simulations with gasoline chemical kinetics were performed to determine the impact of breathing and fuel injection strategies on thermal and compositional stratification, combustion and emissions during homogeneous charge compression ignition combustion. The simulations examined positive valve overlap and negative valve overlap strategies, along with fueling by port fuel injection and direct injection. The resulting charge mass distributions were analyzed prior to ignition using ignition delay as a reactivity metric. The reactivity stratification arising from differences in the distributions of fuel–oxygen equivalence ratio (Φ FO), oxygen molar fraction (χ O2) and temperature (T) was determined for threemore » parametric studies. In the first study, the reactivity stratification and burn duration for positive valve overlap valve events with port fuel injection and early direct injection were nearly identical and were dominated by wall-driven thermal stratification. nitrogen oxide (NO) and carbon monoxide (CO) emissions were negligible for both injection strategies. In the second study, which examined negative valve overlap valve events with direct injection and port fuel injection, reactivity stratification increased for direct injection as the Φ FO and T distributions associated with direct fuel injection into the hot residual gas were positively correlated; however, the latent heat absorbed from the hot residual gas by the evaporating direct injection fuel jet reduced the overall thermal and reactivity stratification. These stratification effects were offsetting, resulting in similar reactivity stratification and burn durations for the two injection strategies. The higher local burned gas temperatures with direct injection resulted in an order of magnitude increase in NO, while incomplete combustion of locally over-lean regions led to a sevenfold increase in CO emissions compared to port fuel injection. The final study evaluated positive valve overlap and negative valve overlap valve events with direct injection. Furthermore, relative to positive valve overlap, the negative valve overlap condition had a wider reactivity stratification, a longer burn duration and higher NO and CO emissions associated with reduced fuel–air mixing.« less

Evaluation of phenolic compounds in virgin olive oil by direct injection in high-performance liquid chromatography with fluorometric detection.

PubMed

Selvaggini, Roberto; Servili, Maurizio; Urbani, Stefania; Esposto, Sonia; Taticchi, Agnese; Montedoro, GianFrancesco

2006-04-19

Hydrophilic phenols are the most abundant natural antioxidants of virgin olive oil (VOO), in which tocopherols and carotenes are also present. The prevalent classes of hydrophilic phenols found in VOO are phenyl alcohols, phenolic acids, secoiridoids such as the dialdehydic form of decarboxymethyl elenolic acid linked to (3,4-dihydroxyphenyl)ethanol or (p-hydroxypheny1)ethanol (3,4-DHPEA-EDA or p-HPEA-EDA) and an isomer of the oleuropein aglycon (3,4-DHPEA-EA), lignans such as (+)-1-acetoxypinoresinol and (+)-pinoresinol, and flavonoids. A new method for the analysis of VOO hydrophilic phenols by direct injection in high-performance liquid chromatography (HPLC) with the use of a fluorescence detector (FLD) has been proposed and compared with the traditional liquid-liquid extraction technique followed by the HPLC analysis utilizing a diode array detector (DAD) and a FLD. Results show that the most important classes of phenolic compounds occurring in VOO can be evaluated using HPLC direct injection. The efficiency of the new method, as compared to the liquid-liquid extraction, was higher to quantify phenyl alcohols, lignans, and 3,4-DHPEA-EA and lower for the evaluation of 3,4-DHPEA-EDA and p-HPEA-EDA.

Thermionic emission and tunneling at carbon nanotube-organic semiconductor interface.

PubMed

Sarker, Biddut K; Khondaker, Saiful I

2012-06-26

We study the charge carrier injection mechanism across the carbon nanotube (CNT)-organic semiconductor interface using a densely aligned carbon nanotube array as electrode and pentacene as organic semiconductor. The current density-voltage (J-V) characteristics measured at different temperatures show a transition from a thermal emission mechanism at high temperature (above 200 K) to a tunneling mechanism at low temperature (below 200 K). A barrier height of ∼0.16 eV is calculated from the thermal emission regime, which is much lower compared to the metal/pentacene devices. At low temperatures, the J-V curves exhibit a direct tunneling mechanism at low bias, corresponding to a trapezoidal barrier, while at high bias the mechanism is well described by Fowler-Nordheim tunneling, which corresponds to a triangular barrier. A transition from direct tunneling to Fowler-Nordheim tunneling further signifies a small injection barrier at the CNT/pentacene interface. Our results presented here are the first direct experimental evidence of low charge carrier injection barrier between CNT electrodes and an organic semiconductor and are a significant step forward in realizing the overall goal of using CNT electrodes in organic electronics.

Transient neurologic deficit after spinal anesthesia: local anesthetic maldistribution with pencil point needles?

PubMed

Beardsley, D; Holman, S; Gantt, R; Robinson, R A; Lindsey, J; Bazaral, M; Stewart, S F; Stevens, R A

1995-08-01

Recent reports of transient neurologic deficits have raised concern about the potential toxicity of single-dose spinal 5% lidocaine in 7.5% dextrose. Two cases of volunteers who experienced minor local sensory deficits after slow (60 s) injections of 2 mL 5% lidocaine via Whitacre needles are described. One case was a result of a double injection because of a "failed" block. It seemed possible that the neurologic deficit in these cases resulted from neurotoxicity associated with maldistribution of local anesthetic. Using an in vitro spinal model, we investigated drug distribution resulting from injections through side-port spinal needles to determine whether the use of these needles could result in high local concentrations of hyperbaric solutions. A spinal canal model was fabricated using human magnetic resonance measurements. The model was placed in a surgical supine position and filled with lactated Ringer's solution to simulate the specific gravity of cerebral spinal fluid at 22 degrees C. A hyperbaric solution of phthalocyanine blue dye and dextrose (SG 1.042), simulating the anesthetic, was injected through three different needles (27-gauge 4 11/16-in. Whitacre, 25-gauge 3 1/2-in. Whitacre, 25-gauge 3 1/2-in. Quincke). Triplicate injections were done at rapid (2 mL/10 s) and slow (2 mL/60 s) rates, with needle side ports oriented in a sacral and cephalad direction. At slow rates of injection, using 27- or 25-gauge sacrally directed Whitacre needles, injections showed evidence of maldistribution with extrapolated peak sacral lidocaine concentrations reaching 2.0%. In contrast, distribution after slow injection through sacrally directed Quincke needles was uniform.(ABSTRACT TRUNCATED AT 250 WORDS)

Lean direct wall fuel injection method and devices

NASA Technical Reports Server (NTRS)

Choi, Kyung J. (Inventor); Tacina, Robert (Inventor)

2000-01-01

A fuel combustion chamber, and a method of and a nozzle for mixing liquid fuel and air in the fuel combustion chamber in lean direct injection combustion for advanced gas turbine engines, including aircraft engines. Liquid fuel in a form of jet is injected directly into a cylindrical combustion chamber from the combustion chamber wall surface in a direction opposite to the direction of the swirling air at an angle of from about 50.degree. to about 60.degree. with respect to a tangential line of the cylindrical combustion chamber and at a fuel-lean condition, with a liquid droplet momentum to air momentum ratio in the range of from about 0.05 to about 0.12. Advanced gas turbines benefit from lean direct wall injection combustion. The lean direct wall injection technique of the present invention provides fast, uniform, well-stirred mixing of fuel and air. In addition, in order to further improve combustion, the fuel can be injected at a venturi located in the combustion chamber at a point adjacent the air swirler.

Performance of CO2 enrich CNG in direct injection engine

NASA Astrophysics Data System (ADS)

Firmansyah, W. B.; Ayandotun, E. Z.; Zainal, A.; Aziz, A. R. A.; Heika, M. R.

2015-12-01

This paper investigates the potential of utilizing the undeveloped natural gas fields in Malaysia with high carbon dioxide (CO2) content ranging from 28% to 87%. For this experiment, various CO2 proportions by volume were added to pure natural gas as a way of simulating raw natural gas compositions in these fields. The experimental tests were carried out using a 4-stroke single cylinder spark ignition (SI) direct injection (DI) compressed natural gas (CNG) engine. The tests were carried out at 180° and 300° before top dead centre (BTDC) injection timing at 3000 rpm, to establish the effects on the engine performance. The results show that CO2 is suppressing the combustion of CNG while on the other hand CNG combustion is causing CO2 dissociation shown by decreasing CO2 emission with the increase in CO2 content. Results for 180° BTDC injection timing shows higher performance compared to 300° BTDC because of two possible reasons, higher volumetric efficiency and higher stratification level. The results also showed the possibility of increasing the CO2 content by injection strategy.

Direct observation of the phase space footprint of a painting injection in the Rapid Cycling Synchrotron at the Japan Proton Accelerator Research Complex

NASA Astrophysics Data System (ADS)

Saha, P. K.; Shobuda, Y.; Hotchi, H.; Hayashi, N.; Takayanagi, T.; Harada, H.; Irie, Y.

2009-04-01

The 3 GeV Rapid Cycling Synchrotron (RCS) at Japan Proton Accelerator Research Complex is nearly at the operational stage with regard to the beam commissioning aspects. Recently, the design painting injection study has been commenced with the aim of high output beam power at the extraction. In order to observe the phase space footprint of the painting injection, a method was developed utilizing a beam position monitor (BPM) in the so-called single pass mode. The turn-by-turn phase space coordinates of the circulating beam directly measured using a pair of BPMs entirely positioned in drift space, and the calculated transfer matrices from the injection point to the pair of BPMs with several successive turns were used together in order to obtain the phase space footprint of the painting injection. There are two such pairs of BPMs placed in two different locations in the RCS, the results from which both agreed and were quite consistent with what was expected.

The effect of CNC and manual laser machining on electrical resistance of HDPE/MWCNT composite

NASA Astrophysics Data System (ADS)

Mohammadi, Fatemeh; Farshbaf Zinati, Reza; Fattahi, A. M.

2018-05-01

In this study, electrical conductivity of high-density polyethylene (HDPE)/multi-walled carbon nanotube (MWCNT) composite was investigated after laser machining. To this end, produced using plastic injection process, nano-composite samples were laser machined with various combinations of input parameters such as feed rate (35, 45, and 55 mm/min), feed angle with injection flow direction (0°, 45°, and 90°), and MWCNT content (0.5, 1, and 1.5 wt%). The angle between laser feed and injected flow direction was set via either of two different methods: CNC programming and manual setting. The results showed that the parameters of angle between laser line and melt flow direction and feed rate were both found to have statistically significance and physical impacts on electrical resistance of the samples in manual setting. Also, maximum conductivity was seen when the angle between laser line and melt flow direction was set to 90° in manual setting, and maximum conductivity was seen at feed rate of 55 mm/min in both of CNC programming and manual setting.

Using Direct Metal Deposition to Fabricate Mold Plates for an Injection Mold Machine Allowing for the Evaluation of Cost Effective Near-Sourcing Opportunities in Larger, High Volume Consumer Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duty, Chad E; Groh, Bill

2014-10-31

ORNL collaborated with Radio Systems Corporation to investigate additive manufacturing (AM) of mold plates for plastic injection molding by direct metal deposition. The team s modelling effort identified a 100% improvement in heat transfer through use of conformal cooling lines that could be built into the mold using a revolutionary design enabled by additive manufacturing. Using the newly installed laser deposition system at the ORNL Manufacturing Demonstration Facility (MDF) a stainless steel mold core was printed.

Observation of plasma rotation driven by static nonaxisymmetric magnetic fields in a tokamak.

PubMed

Garofalo, A M; Burrell, K H; DeBoo, J C; deGrassie, J S; Jackson, G L; Lanctot, M; Reimerdes, H; Schaffer, M J; Solomon, W M; Strait, E J

2008-11-07

We present the first evidence for the existence of a neoclassical toroidal rotation driven in a direction counter to the plasma current by nonaxisymmetric, nonresonant magnetic fields. At high beta and with large injected neutral beam momentum, the nonresonant field torque slows down the plasma toward the neoclassical "offset" rotation rate. With small injected neutral beam momentum, the toroidal rotation is accelerated toward the offset rotation, with resulting improvement in the global energy confinement time. The observed magnitude, direction, and radial profile of the offset rotation are consistent with neoclassical theory predictions.

Integrated on-line system for DNA sequencing by capillary electrophoresis: From template to called bases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ton, H.; Yeung, E.S.

1997-02-15

An integrated on-line prototype for coupling a microreactor to capillary electrophoresis for DNA sequencing has been demonstrated. A dye-labeled terminator cycle-sequencing reaction is performed in a fused-silica capillary. Subsequently, the sequencing ladder is directly injected into a size-exclusion chromatographic column operated at nearly 95{degree}C for purification. On-line injection to a capillary for electrophoresis is accomplished at a junction set at nearly 70{degree}C. High temperature at the purification column and injection junction prevents the renaturation of DNA fragments during on-line transfer without affecting the separation. The high solubility of DNA in and the relatively low ionic strength of 1 x TEmore » buffer permit both effective purification and electrokinetic injection of the DNA sample. The system is compatible with highly efficient separations by a replaceable poly(ethylene oxide) polymer solution in uncoated capillary tubes. Future automation and adaptation to a multiple-capillary array system should allow high-speed, high-throughput DNA sequencing from templates to called bases in one step. 32 refs., 5 figs.« less

Researches on direct injection in internal-combustion engines

NASA Technical Reports Server (NTRS)

Tuscher, Jean E

1941-01-01

These researches present a solution for reducing the fatigue of the Diesel engine by permitting the preservation of its components and, at the same time, raising its specific horsepower to a par with that of carburetor engines, while maintaining for the Diesel engine its perogative of burning heavy fuel under optimum economical conditions. The feeding of Diesel engines by injection pumps actuated by engine compression achieves the required high speeds of injection readily and permits rigorous control of the combustible charge introduced into each cylinder and of the peak pressure in the resultant cycle.

High Speed Laser with 100 Ghz Resonance Frequency

DTIC Science & Technology

2014-02-28

applications, such as opto - electronic oscillators . Recently, however, by optimizing the detuning frequency and injection ratio, we have shown enhanced...semiconductor lasers has been limited by relaxation oscillation frequency to < 40 GHz. By using strong optical injection locking, we report resonance...direct modulation bandwidth of semiconductor lasers. In a typical laser, the relaxation oscillation [resonance] frequency is a figure-of-merit that is a

Anisotropy in Fracking: A Percolation Model for Observed Microseismicity

NASA Astrophysics Data System (ADS)

Norris, J. Quinn; Turcotte, Donald L.; Rundle, John B.

2015-01-01

Hydraulic fracturing (fracking), using high pressures and a low viscosity fluid, allow the extraction of large quantiles of oil and gas from very low permeability shale formations. The initial production of oil and gas at depth leads to high pressures and an extensive distribution of natural fractures which reduce the pressures. With time these fractures heal, sealing the remaining oil and gas in place. High volume fracking opens the healed fractures allowing the oil and gas to flow to horizontal production wells. We model the injection process using invasion percolation. We use a 2D square lattice of bonds to model the sealed natural fractures. The bonds are assigned random strengths and the fluid, injected at a point, opens the weakest bond adjacent to the growing cluster of opened bonds. Our model exhibits burst dynamics in which the clusters extend rapidly into regions with weak bonds. We associate these bursts with the microseismic activity generated by fracking injections. A principal object of this paper is to study the role of anisotropic stress distributions. Bonds in the y-direction are assigned higher random strengths than bonds in the x-direction. We illustrate the spatial distribution of clusters and the spatial distribution of bursts (small earthquakes) for several degrees of anisotropy. The results are compared with observed distributions of microseismicity in a fracking injection. Both our bursts and the observed microseismicity satisfy Gutenberg-Richter frequency-size statistics.

Determination of low molecular weight alcohols including fusel oil in various samples by diethyl ether extraction and capillary gas chromatography.

PubMed

Woo, Kang-Lyung

2005-01-01

Low molecular weight alcohols including fusel oil were determined using diethyl ether extraction and capillary gas chromatography. Twelve kinds of alcohols were successfully resolved on the HP-FFAP (polyethylene glycol) capillary column. The diethyl ether extraction method was very useful for the analysis of alcohols in alcoholic beverages and biological samples with excellent cleanliness of the resulting chromatograms and high sensitivity compared to the direct injection method. Calibration graphs for all standard alcohols showed good linearity in the concentration range used, 0.001-2% (w/v) for all alcohols. Salting out effects were significant (p < 0.01) for the low molecular weight alcohols methanol, isopropanol, propanol, 2-butanol, n-butanol and ethanol, but not for the relatively high molecular weight alcohols amyl alcohol, isoamyl alcohol, and heptanol. The coefficients of variation of the relative molar responses were less than 5% for all of the alcohols. The limits of detection and quantitation were 1-5 and 10-60 microg/L for the diethyl ether extraction method, and 10-50 and 100-350 microg/L for the direct injection method, respectively. The retention times and relative retention times of standard alcohols were significantly shifted in the direct injection method when the injection volumes were changed, even with the same analysis conditions, but they were not influenced in the diethyl ether extraction method. The recoveries by the diethyl ether extraction method were greater than 95% for all samples and greater than 97% for biological samples.

Early direct-injection, low-temperature combustion of diesel fuel in an optical engine utilizing a 15-hole, dual-row, narrow-included-angle nozzle.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gehrke, Christopher R.; Radovanovic, Michael S.; Milam, David M.

2008-04-01

Low-temperature combustion of diesel fuel was studied in a heavy-duty, single-cylinder optical engine employing a 15-hole, dual-row, narrow-included-angle nozzle (10 holes x 70/mD and 5 holes x 35/mD) with 103-/gmm-diameter orifices. This nozzle configuration provided the spray targeting necessary to contain the direct-injected diesel fuel within the piston bowl for injection timings as early as 70/mD before top dead center. Spray-visualization movies, acquired using a high-speed camera, show that impingement of liquid fuel on the piston surface can result when the in-cylinder temperature and density at the time of injection are sufficiently low. Seven single- and two-parameter sweeps around amore » 4.82-bar gross indicated mean effective pressure load point were performed to map the sensitivity of the combustion and emissions to variations in injection timing, injection pressure, equivalence ratio, simulated exhaust-gas recirculation, intake temperature, intake boost pressure, and load. High-speed movies of natural luminosity were acquired by viewing through a window in the cylinder wall and through a window in the piston to provide quasi-3D information about the combustion process. These movies revealed that advanced combustion phasing resulted in intense pool fires within the piston bowl, after the end of significant heat release. These pool fires are a result of fuel-films created when the injected fuel impinged on the piston surface. The emissions results showed a strong correlation with pool-fire activity. Smoke and NO/dx emissions rose steadily as pool-fire intensity increased, whereas HC and CO showed a dramatic increase with near-zero pool-fire activity.« less

In-situ chemical barrier and method of making

DOEpatents

Cantrell, K.J.; Kaplan, D.I.

1999-01-12

A chemical barrier is formed by injecting a suspension of solid particles or colloids into the subsurface. First, a stable colloid suspension is made including a surfactant and a non-Newtonian fluid. This stable colloid suspension is characterized by colloid concentration, colloid size, colloid material, solution ionic strength, and chemical composition. A second step involves injecting the optimized stable colloid suspension at a sufficiently high flow rate to move the colloids through the subsurface sediment, but not at such a high rate so as to induce resuspending indigenous soil particles in the aquifer. While injecting the stable colloid suspension, a withdrawal well may be used to draw the injected colloids in a direction perpendicular to the flow path of a contaminant plume. The withdrawal well, may then be used as an injection well, and a third well, in line with the first two wells, may then be used as a withdrawal well, thereby increasing the length of the colloid barrier. This process would continue until emplacement of the colloid barrier is complete. 7 figs.

In-situ chemical barrier and method of making

DOEpatents

Cantrell, Kirk J.; Kaplan, Daniel I.

1999-01-01

A chemical barrier is formed by injecting a suspension of solid particles or colloids into the subsurface. First, a stable colloid suspension is made including a surfactant and a non-Newtonian fluid. This stable colloid suspension is characterized by colloid concentration, colloid size, colloid material, solution ionic strength, and chemical composition. A second step involves injecting the optimized stable colloid suspension at a sufficiently high flow rate to move the colloids through the subsurface sediment, but not at such a high rate so as to induce resuspending indigenous soil particles in the aquifer. While injecting the stable colloid suspension, a withdrawal well may be used to draw the injected colloids in a direction perpendicular to the flow path of a contaminant plume. The withdrawal well, may then be used as an injection well, and a third well, in line with the first two wells, may then be used as a withdrawal well, thereby increasing the length of the colloid barrier. This process would continue until emplacement of the colloid barrier is complete.

Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer.

PubMed

Niikura, Hitoshi; Kaiho-Sakuma, Michiko; Tokunaga, Hideki; Toyoshima, Masafumi; Utsunomiya, Hiroki; Nagase, Satoru; Takano, Tadao; Watanabe, Mika; Ito, Kiyoshi; Yaegashi, Nobuo

2013-11-01

The aim of the present study was to clarify the most effective combination of injected tracer types and injection sites in order to detect sentinel lymph nodes (SLNs) in early endometrial cancer. The study included 100 consecutive patients with endometrial cancer treated at Tohoku University Hospital between June 2001 and December 2012. The procedure for SLN identification entailed either radioisotope (RI) injection into the endometrium during hysteroscopy (55 cases) or direct RI injection into the uterine cervix (45 cases). A combination of blue dye injected into the uterine cervix or uterine body intraoperatively in addition to preoperative RI injection occurred in 69 of 100 cases. All detected SLNs were recorded according to the individual tracer and the resultant staging from this method was compared to the final pathology of lymph node metastases including para-aortic nodes. SLN detection rate was highest (96%) by cervical RI injection; however, no SLNs were detected in para-aortic area. Para-aortic SLNs were detected only by hysteroscopic RI injection (56%). All cases with pelvic lymph node metastases were detected by pelvic SLN biopsy. Isolated positive para-aortic lymph nodes were detected in 3 patients. Bilateral SLN detection rate was high (96%; 26 of 27 cases) by cervical RI injection combined with dye. RI injection into the uterine cervix is highly sensitive in detection of SLN metastasis in early stage endometrial cancer. It is a useful and safe modality when combined with blue dye injection into the uterine body. © 2013.

Diesel Combustion and Emission Using High Boost and High Injection Pressure in a Single Cylinder Engine

NASA Astrophysics Data System (ADS)

Aoyagi, Yuzo; Kunishima, Eiji; Asaumi, Yasuo; Aihara, Yoshiaki; Odaka, Matsuo; Goto, Yuichi

Heavy-duty diesel engines have adopted numerous technologies for clean emissions and low fuel consumption. Some are direct fuel injection combined with high injection pressure and adequate in-cylinder air motion, turbo-intercooler systems, and strong steel pistons. Using these technologies, diesel engines have achieved an extremely low CO2 emission as a prime mover. However, heavy-duty diesel engines with even lower NOx and PM emission levels are anticipated. This study achieved high-boost and lean diesel combustion using a single cylinder engine that provides good engine performance and clean exhaust emission. The experiment was done under conditions of intake air quantity up to five times that of a naturally aspirated (NA) engine and 200MPa injection pressure. The adopted pressure booster is an external supercharger that can control intake air temperature. In this engine, the maximum cylinder pressure was increased and new technologies were adopted, including a monotherm piston for endurance of Pmax =30MPa. Moreover, every engine part is newly designed. As the boost pressure increases, the rate of heat release resembles the injection rate and becomes sharper. The combustion and brake thermal efficiency are improved. This high boost and lean diesel combustion creates little smoke; ISCO and ISTHC without the ISNOx increase. It also yields good thermal efficiency.

Reactor and method for hydrocracking carbonaceous material

DOEpatents

Duncan, Dennis A.; Beeson, Justin L.; Oberle, R. Donald; Dirksen, Henry A.

1980-01-01

Solid, carbonaceous material is cracked in the presence of hydrogen or other reducing gas to provide aliphatic and aromatic hydrocarbons of lower molecular weight for gaseous and liquid fuels. The carbonaceous material, such as coal, is entrained as finely divided particles in a flow of reducing gas and preheated to near the decomposition temperature of the high molecular weight polymers. Within the reactor, small quantities of oxygen containing gas are injected at a plurality of discrete points to burn corresponding amounts of the hydrogen or other fuel and elevate the mixture to high temperatures sufficient to decompose the high molecular weight, carbonaceous solids. Turbulent mixing at each injection point rapidly quenches the material to a more moderate bulk temperature. Additional quenching after the final injection point can be performed by direct contact with quench gas or oil. The reactions are carried out in the presence of a hydrogen-containing reducing gas at moderate to high pressure which stabilizes the products.

An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy.

PubMed

Portela, Ana; Vasconcelos, Mário; Branco, Rogério; Gartner, Fátima; Faria, Miguel; Cavalheiro, José

2010-08-01

The cancer treatment by local hyperthermia, using a high frequency electromagnetic field is an extensively studied subject. For this propose it was developed a ferrimagnetic cement (FC) to be injected directly into the tumor. In this study it was determined the FC injectability, its capability to generate heat when placed within a magnetic field and its interaction with a modified simulated body fluid using SEM/EDS and XRD. The FC biological response was assessed by the intramuscular implantation in rats and histological analysis of the surrounding tissues. The results suggest that FC can be injected directly into the tumor, its temperature can be increased when exposed to a magnetic field and the surface of the immersed samples quickly becomes coated with precipitate denoting its ionic change with the surrounding medium. The histological analysis revealed a transient local inflammatory reaction, similar to the control material, only slightly more abundant during the first weeks, with a gradual decrease over the implantation time. Based on these results, we concluded that FC might be useful for highly focalized thermotherapy, with a good potential for clinical use.

Development of an Ethanol Blend Two-Stroke Direct-Injection Snowmobile for Use in the Clean Snowmobile Challenge and National Parks

DOT National Transportation Integrated Search

2010-09-01

The University of Idaho's entry into the 2010 SAE Clean Snowmobile Challenge (CSC) was a direct-injection (DI) two-stroke powered snowmobile modified to use blended ethanol fuel. The modulated and battery-less direct-injection system used to decrease...

Field assessment of guar gum stabilized microscale zerovalent iron particles for in-situ remediation of 1,1,1-trichloroethane.

PubMed

Velimirovic, Milica; Tosco, Tiziana; Uyttebroek, Maarten; Luna, Michela; Gastone, Francesca; De Boer, Cjestmir; Klaas, Norbert; Sapion, Hans; Eisenmann, Heinrich; Larsson, Per-Olof; Braun, Juergen; Sethi, Rajandrea; Bastiaens, Leen

2014-08-01

A pilot injection test with guar gum stabilized microscale zerovalent iron (mZVI) particles was performed at test site V (Belgium) where different chlorinated aliphatic hydrocarbons (CAHs) were present as pollutants in the subsurface. One hundred kilograms of 56μm-diameter mZVI (~70gL(-1)) was suspended in 1.5m(3) of guar gum (~7gL(-1)) solution and injected into the test area. In order to deliver the guar gum stabilized mZVI slurry, one direct push bottom-up injection (Geoprobe) was performed with injections at 5 depths between 10.5 and 8.5m bgs. The direct push technique was preferred above others (e.g. injection at low flow rate via screened wells) because of the limited hydraulic conductivity of the aquifer, and to the large size of the mZVI particles. A final heterogeneous distribution of the mZVI in the porous medium was observed explicable by preferential flow paths created during the high pressure injection. The maximum observed delivery distance was 2.5m. A significant decrease in 1,1,1-TCA concentrations was observed in close vicinity of spots where the highest concentration of mZVI was observed. Carbon stable isotope analysis (CSIA) yielded information on the success of the abiotic degradation of 1,1,1-TCA and indicated a heterogeneous spatio-temporal pattern of degradation. Finally, the obtained results show that mZVI slurries stabilized by guar gum can be prepared at pilot scale and directly injected into low permeable aquifers, indicating a significant removal of 1,1,1-TCA. Copyright © 2014 Elsevier B.V. All rights reserved.

Field assessment of guar gum stabilized microscale zerovalent iron particles for in-situ remediation of 1,1,1-trichloroethane

NASA Astrophysics Data System (ADS)

Velimirovic, Milica; Tosco, Tiziana; Uyttebroek, Maarten; Luna, Michela; Gastone, Francesca; De Boer, Cjestmir; Klaas, Norbert; Sapion, Hans; Eisenmann, Heinrich; Larsson, Per-Olof; Braun, Juergen; Sethi, Rajandrea; Bastiaens, Leen

2014-08-01

A pilot injection test with guar gum stabilized microscale zerovalent iron (mZVI) particles was performed at test site V (Belgium) where different chlorinated aliphatic hydrocarbons (CAHs) were present as pollutants in the subsurface. One hundred kilograms of 56 μm-diameter mZVI (~ 70 g L- 1) was suspended in 1.5 m3 of guar gum (~ 7 g L- 1) solution and injected into the test area. In order to deliver the guar gum stabilized mZVI slurry, one direct push bottom-up injection (Geoprobe) was performed with injections at 5 depths between 10.5 and 8.5 m bgs. The direct push technique was preferred above others (e.g. injection at low flow rate via screened wells) because of the limited hydraulic conductivity of the aquifer, and to the large size of the mZVI particles. A final heterogeneous distribution of the mZVI in the porous medium was observed explicable by preferential flow paths created during the high pressure injection. The maximum observed delivery distance was 2.5 m. A significant decrease in 1,1,1-TCA concentrations was observed in close vicinity of spots where the highest concentration of mZVI was observed. Carbon stable isotope analysis (CSIA) yielded information on the success of the abiotic degradation of 1,1,1-TCA and indicated a heterogeneous spatio-temporal pattern of degradation. Finally, the obtained results show that mZVI slurries stabilized by guar gum can be prepared at pilot scale and directly injected into low permeable aquifers, indicating a significant removal of 1,1,1-TCA.

Flowing gas, non-nuclear experiments on the gas core reactor

NASA Technical Reports Server (NTRS)

Kunze, J. F.; Suckling, D. H.; Copper, C. G.

1972-01-01

Flow tests were conducted on models of the gas core (cavity) reactor. Variations in cavity wall and injection configurations were aimed at establishing flow patterns that give a maximum of the nuclear criticality eigenvalue. Correlation with the nuclear effect was made using multigroup diffusion theory normalized by previous benchmark critical experiments. Air was used to simulate the hydrogen propellant in the flow tests, and smoked air, argon, or freon to simulate the central nuclear fuel gas. All tests were run in the down-firing direction so that gravitational effects simulated the acceleration effect of a rocket. Results show that acceptable flow patterns with high volume fraction for the simulated nuclear fuel gas and high flow rate ratios of propellant to fuel can be obtained. Using a point injector for the fuel, good flow patterns are obtained by directing the outer gas at high velocity along the cavity wall, using louvered or oblique-angle-honeycomb injection schemes.

Acceleration of low-energy ions at parallel shocks with a focused transport model

DOE PAGES

Zuo, Pingbing; Zhang, Ming; Rassoul, Hamid K.

2013-04-10

Here, we present a test particle simulation on the injection and acceleration of low-energy suprathermal particles by parallel shocks with a focused transport model. The focused transport equation contains all necessary physics of shock acceleration, but avoids the limitation of diffusive shock acceleration (DSA) that requires a small pitch angle anisotropy. This simulation verifies that the particles with speeds of a fraction of to a few times the shock speed can indeed be directly injected and accelerated into the DSA regime by parallel shocks. At higher energies starting from a few times the shock speed, the energy spectrum of acceleratedmore » particles is a power law with the same spectral index as the solution of standard DSA theory, although the particles are highly anisotropic in the upstream region. The intensity, however, is different from that predicted by DSA theory, indicating a different level of injection efficiency. It is found that the shock strength, the injection speed, and the intensity of an electric cross-shock potential (CSP) jump can affect the injection efficiency of the low-energy particles. A stronger shock has a higher injection efficiency. In addition, if the speed of injected particles is above a few times the shock speed, the produced power-law spectrum is consistent with the prediction of standard DSA theory in both its intensity and spectrum index with an injection efficiency of 1. CSP can increase the injection efficiency through direct particle reflection back upstream, but it has little effect on the energetic particle acceleration once the speed of injected particles is beyond a few times the shock speed. This test particle simulation proves that the focused transport theory is an extension of DSA theory with the capability of predicting the efficiency of particle injection.« less

Performance characteristics of LOX-H2, tangential-entry, swirl-coaxial, rocket injectors

NASA Technical Reports Server (NTRS)

Howell, Doug; Petersen, Eric; Clark, Jim

1993-01-01

Development of a high performing swirl-coaxial injector requires an understanding of fundamental performance characteristics. This paper addresses the findings of studies on cold flow atomic characterizations which provided information on the influence of fluid properties and element operating conditions on the produced droplet sprays. These findings are applied to actual rocket conditions. The performance characteristics of swirl-coaxial injection elements under multi-element hot-fire conditions were obtained by analysis of combustion performance data from three separate test series. The injection elements are described and test results are analyzed using multi-variable linear regression. A direct comparison of test results indicated that reduced fuel injection velocity improved injection element performance through improved propellant mixing.

Anterograde and retrograde tracing with high molecular weight biotinylated dextran amine through thalamocortical and corticothalamic pathways.

PubMed

Zhang, Wenjie; Xu, Dongsheng; Cui, Jingjing; Jing, Xianghong; Xu, Nenggui; Liu, Jianhua; Bai, Wanzhu

2017-02-01

Biotinylated dextran amine (BDA) has been used for neural pathway tracing in the central nervous system for many decades, in which high molecular weight BDA appeared to be transported predominantly in the anterograde direction and less in the retrograde direction. In the current study, we reexamined the properties of neural labeling with high molecular weight BDA through a reciprocal neural pathway between thalamus and somatosensory cortex. After injection of BDA into the ventral posteromedial nucleus of thalamus (VPM) in the rat, the BDA labeling was sequentially examined on somatosensory cortex at 3, 5, 7, 10, and 14 survival days. Both of anterogradely labeled axonal terminals and retrogradely labeled neuronal cell bodies were observed simultaneously on the somatosensory cortex. With the increasing of survival times after injection, morphological changes occurred on the labeled axonal arbors and neuronal dendrites, in which the high quality of BDA labeling appeared on the tenth survival day. These results indicate that high molecular weight BDA is not only a sensitive anterograde tracer but also an excellent retrograde marker to be used for tracing through thalamocortical and corticothalamic pathways. And the detailed structure of neural labeling with BDA similar to Golgi-like resolution can be obtained at optimal survival times of animals after the injection of high molecular weight BDA. © 2016 Wiley Periodicals, Inc.

Significant relaxation of residual negative carrier in polar Alq3 film directly detected by high-sensitivity photoemission

NASA Astrophysics Data System (ADS)

Kinjo, Hiroumi; Lim, Hyunsoo; Sato, Tomoya; Noguchi, Yutaka; Nakayama, Yasuo; Ishii, Hisao

2016-02-01

Tris(8-hydroxyquinoline)aluminum (Alq3) has been widely applied as a good electron-injecting layer (EIL) in organic light-emitting diodes. High-sensitivity photoemission measurement revealed a clear photoemission by visible light, although its ionization energy is 5.7 eV. This unusual photoemission is ascribed to Alq3 anions captured by positive polarization charges. The observed electron detachment energy of the anion was about 1 eV larger than the electron affinity reported by inverse photoemission. This difference suggests that the injected electron in the Alq3 layer is energetically relaxed, leading to the reduction in injection barrier. This nature is one of the reasons why Alq3 worked well as the EIL.

Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography.

PubMed

Fitz, Brian D; Mannion, Brandyn C; To, Khang; Hoac, Trinh; Synovec, Robert E

2015-05-01

Low thermal mass gas chromatography (LTM-GC) was evaluated for rapid, high peak capacity separations with three injection methods: liquid, headspace solid phase micro-extraction (HS-SPME), and direct vapor. An Agilent LTM equipped with a short microbore capillary column was operated at a column heating rate of 250 °C/min to produce a 60s separation. Two sets of experiments were conducted in parallel to characterize the instrumental platform. First, the three injection methods were performed in conjunction with in-house built high-speed cryo-focusing injection (HSCFI) to cryogenically trap and re-inject the analytes onto the LTM-GC column in a narrower band. Next, the three injection methods were performed natively with LTM-GC. Using HSCFI, the peak capacity of a separation of 50 nl of a 73 component liquid test mixture was 270, which was 23% higher than without HSCFI. Similar peak capacity gains were obtained when using the HSCFI with HS-SPME (25%), and even greater with vapor injection (56%). For the 100 μl vapor sample injected without HSCFI, the preconcentration factor, defined as the ratio of the maximum concentration of the detected analyte peak relative to the analyte concentration injected with the syringe, was determined to be 11 for the earliest eluting peak (most volatile analyte). In contrast, the preconcentration factor for the earliest eluting peak using HSCFI was 103. Therefore, LTM-GC is demonstrated to natively provide in situ analyte trapping, although not to as great an extent as with HSCFI. We also report the use of LTM-GC applied with time-of-flight mass spectrometry (TOFMS) detection for rapid, high peak capacity separations from SPME sampled banana peel headspace. Copyright © 2015 Elsevier B.V. All rights reserved.

Serum hepcidin levels and muscle iron proteins in humans injected with low- or high-dose erythropoietin.

PubMed

Robach, Paul; Recalcati, Stefania; Girelli, Domenico; Campostrini, Natascia; Kempf, Tibor; Wollert, Kai C; Corbella, Michela; Santambrogio, Paolo; Perbellini, Luigi; Brasse-Lagnel, Carole; Christensen, Britt; Moutereau, Stéphane; Lundby, Carsten; Cairo, Gaetano

2013-07-01

Inhibition of hepcidin expression by erythropoietic signals is of great physiological importance; however, the inhibitory pathways remain poorly understood. To investigate (i) the direct effect of erythropoietin (Epo) and (ii) the contribution of putative mediators on hepcidin repression, healthy volunteers were injected with a single dose of Epo, either low (63 IU/kg, n = 8) or high (400 IU/kg, n = 6). Low-dose Epo provoked hepcidin down-modulation within 24 h; the effect was not immediate as hepcidin circadian variations were still present following injection. High-dose Epo induced no additional effect on the hepcidin response, that is hepcidin diurnal fluctuations were not abolished in spite of extremely high Epo levels. We did not find significant changes in putative mediators of hepcidin repression, such as transferrin saturation, soluble transferrin receptor, or growth differentiation factor 15. Furthermore, the potential hepcidin inhibitor, soluble hemojuvelin, was found unaltered by Epo stimulation. This finding was consistent with the absence of signs of iron deficiency observed at the level of skeletal muscle tissue. Our data suggest that hepcidin repression by erythropoietic signals in humans may not be controlled directly by Epo, but mediated by a still undefined factor. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Evaluation of a direct injection nebulizer interface for flow injection analysis and high performance liquid chromatography with inductively coupled plasma-atomic emission spectroscopic detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, K.E.

A direct injection nebulizer (DIN) was designed, developed and evaluated to determine its potential utilization as an effective interface for flow injection analysis (FIA) and high performance liquid chromatography (HPLC) coupled with inductively coupled plasma-atomic emission spectroscopic detection. The analytical figures of merit for the DIN when used as an interface for FIA-ICP-AES were found to be comparable to or better than those obtained with conventional pneumatic nebulization in terms of limits of detection (LODs), reproducibility, linearity, and interelement effects. In the HPLC mode, the LODDs were found to be comparable to those obtained by continuous-flow sample introduction into themore » ICP, or inferior by up to only a factor of four. Stable plasma operation was maintained for the DIN sample introduction of a variety of pure organic solvents, including acetonitrile, methanol, methyl-isobutylketone, and pyridine. The HPLC-DIN-ICP-AES facility was specifically applied for the speciation of inorganic and organo-metallic species contained in synthetic mixtures, vanilla extracts and a variety of energy-related materials, such as shale oil process water, coal extracts, shale oil, crude oil, and an SRC II. Suggestions for future research are also considered.« less

High HIV Prevalence and Associated Risk Factors Among Female Sexual Partners of Male Injection Drug Users (MWID) in Ho Chi Minh City, Vietnam.

PubMed

Nadol, Patrick; Tran, Hoang; Hammett, Theodore; Phan, Son; Nguyen, Duong; Kaldor, John; Law, Matthew

2016-02-01

Injection drug use is a major factor in acquiring and transmitting HIV in Vietnam. This analysis aims to present estimates of HIV infection and factors associated with HIV infection among female sex partners (FSP) of MWID in Ho Chi Minh City (HCMC), Vietnam. Cross-sectional surveys were conducted in 2011 and 2013 among males who inject drugs (MWID) who then referred their FSP for a behavioral and biologic survey. In total, 445 MWID and FSPs were enrolled. HIV prevalence among MWID was 50 and 35 % among FSPs. Among FSPs, 60.3 % reported ever using illegal drugs and among those, 72.7 % reported ever injecting illicit drugs. Among FSP, injection drug for >1 year [adjusted Odds Ratio (aOR), 95 % CI 2.94, 1.19-7.26), p value = <0.001] and having a male partner infected with HIV [(aOR 3.35: 1.97-5.69), p value = <0.001] were associated with HIV infection. The prevalence of HIV infection is high among FSP of MWID in HCMC and is highly associated with the injection drug use behavior of the FSP. Harm-reduction intervention programs that focus on the MWID-FSP couple or directly on the FSPs are required.

Direct visualization and in-depth physical study of metal filament formation in percolated high-κ dielectrics

NASA Astrophysics Data System (ADS)

Li, X.; Pey, K. L.; Bosman, M.; Liu, W. H.; Kauerauf, T.

2010-01-01

The migration of Ta atoms from a transistor gate electrode into the percolated high-κ (HK) gate dielectrics is directly shown using transmission electron microscopy analysis. A nanoscale metal filament that formed under high current injection is identified to be the physical defect responsible for the ultrafast transient breakdown (BD) of the metal-gate/high-κ (MG/HK) gate stacks. This highly conductive metal filament poses reliability concerns for MG/HK gate stacks as it significantly reduces the post-BD reliability margin of a transistor.

Impact of rail pressure and biodiesel fueling on the particulate morphology and soot nanostructures from a common-rail turbocharged direct injection diesel engine

DOE PAGES

Ye, Peng; Vander Wal, Randy; Boehman, Andre L.; ...

2014-12-26

The effect of rail pressure and biodiesel fueling on the morphology of exhaust particulate agglomerates and the nanostructure of primary particles (soot) was investigated with a common-rail turbocharged direct injection diesel engine. The engine was operated at steady state on a dynamometer running at moderate speed with both low (30%) and medium–high (60%) fixed loads, and exhaust particulate was sampled for analysis. Ultra-low sulfur diesel and its 20% v/v blends with soybean methyl ester biodiesel were used. Fuel injection occurred in a single event around top dead center at three different injection pressures. Exhaust particulate samples were characterized with TEMmore » imaging, scanning mobility particle sizing, thermogravimetric analysis, Raman spectroscopy, and XRD analysis. Particulate morphology and oxidative reactivity were found to vary significantly with rail pressure and with biodiesel blend level. Higher biodiesel content led to increases in the primary particle size and oxidative reactivity but did not affect nanoscale disorder in the as-received samples. For particulates generated with higher injection pressures, the initial oxidative reactivity increased, but there was no detectable correlation with primary particle size or nanoscale disorder.« less

Impact of rail pressure and biodiesel fueling on the particulate morphology and soot nanostructures from a common-rail turbocharged direct injection diesel engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, Peng; Vander Wal, Randy; Boehman, Andre L.

The effect of rail pressure and biodiesel fueling on the morphology of exhaust particulate agglomerates and the nanostructure of primary particles (soot) was investigated with a common-rail turbocharged direct injection diesel engine. The engine was operated at steady state on a dynamometer running at moderate speed with both low (30%) and medium–high (60%) fixed loads, and exhaust particulate was sampled for analysis. Ultra-low sulfur diesel and its 20% v/v blends with soybean methyl ester biodiesel were used. Fuel injection occurred in a single event around top dead center at three different injection pressures. Exhaust particulate samples were characterized with TEMmore » imaging, scanning mobility particle sizing, thermogravimetric analysis, Raman spectroscopy, and XRD analysis. Particulate morphology and oxidative reactivity were found to vary significantly with rail pressure and with biodiesel blend level. Higher biodiesel content led to increases in the primary particle size and oxidative reactivity but did not affect nanoscale disorder in the as-received samples. For particulates generated with higher injection pressures, the initial oxidative reactivity increased, but there was no detectable correlation with primary particle size or nanoscale disorder.« less

Room-temperature continuous-wave electrically injected InGaN-based laser directly grown on Si

NASA Astrophysics Data System (ADS)

Sun, Yi; Zhou, Kun; Sun, Qian; Liu, Jianping; Feng, Meixin; Li, Zengcheng; Zhou, Yu; Zhang, Liqun; Li, Deyao; Zhang, Shuming; Ikeda, Masao; Liu, Sheng; Yang, Hui

2016-09-01

Silicon photonics would greatly benefit from efficient, visible on-chip light sources that are electrically driven at room temperature. To fully utilize the benefits of large-scale, low-cost manufacturing foundries, it is highly desirable to grow direct bandgap III-V semiconductor lasers directly on Si. Here, we report the demonstration of a blue-violet (413 nm) InGaN-based laser diode grown directly on Si that operates under continuous-wave current injection at room temperature, with a threshold current density of 4.7 kA cm-2. The heteroepitaxial growth of GaN on Si is confronted with a large mismatch in both the lattice constant and the coefficient of thermal expansion, often resulting in a high density of defects and even microcrack networks. By inserting an Al-composition step-graded AlN/AlGaN multilayer buffer between the Si and GaN, we have not only successfully eliminated crack formation, but also effectively reduced the dislocation density. The result is the realization of a blue-violet InGaN-based laser on Si.

Low injection losses in InGaN/GaN LEDs: The correlation of photoluminescence, electroluminescence, and photocurrent measurements

NASA Astrophysics Data System (ADS)

Quitsch, Wolf-Alexander; Sager, Daniel; Loewenich, Moritz; Meyer, Tobias; Hahn, Berthold; Bacher, Gerd

2018-06-01

Time-resolved photoluminescence spectroscopy and photocurrent measurements at quasi-resonant laser excitation are combined with electroluminescence studies to get access to low injection losses in high power InGaN/GaN LEDs. A direct relation between electroluminescence and photoluminescence efficiencies with photocurrent is found, indicating that tunneling losses play a key role in the low injection regime. This assertion is confirmed by comparing photoluminescence efficiencies under open and closed circuit conditions. Experiments under various excitation wavelengths hint at the role of resonant tunneling processes in the efficiency losses.

Direct comparison of administration routes for AAV8-mediated ocular gene therapy.

PubMed

Igarashi, Tsutomu; Miyake, Koichi; Asakawa, Nagisa; Miyake, Noriko; Shimada, Takashi; Takahashi, Hiroshi

2013-05-01

We recently demonstrated that direct subretinal (SR) injection of adeno-associated virus (AAV) type 8 (AAV8) into photoreceptor cells and retinal pigment epithelium (RPE) is a highly efficient model of gene delivery. The current study compared transduction efficiency and expression patterns associated with various routes of vector administration. The efficacy of intravitreal (VT), SR and subconjunctival (SC) injections for delivery of AAV8-derived vectors, i.e. those expressing luciferase (Luc) and enhanced green fluorescent protein (GFP) - AAV8/Luc and AAV8/GFP, respectively - were compared in an animal (mouse) model (n = 8 mice/group). Transduction efficiency and expression patterns were examined at post-injection weeks 1 and 2, and months 1, 3, 6 and 12 via in vivo imaging. One year after AAV injection, AAV8/Luc-treated mice exhibited stable and sustained high expression of vector in the VT and SR groups, but not in the SC group (VT:SR:SC = 3,218:2,923:115; 1 × 10(5 )photons/s). Histological analysis showed that GFP expression was observed in the inner retina of VT group mice, and in photoreceptor cells and RPE of SR group mice, whereas no GFP expression was noted in the SC group. Electroretinography (ERG) revealed adverse effects following SR delivery. Results suggest that both SR and VT injections of AAV8 vectors are useful routes for administering ocular gene therapy, and stress the importance of selecting an appropriate administration route, i.e. one that targets specific cells, for treating ocular disorders.

Visualisation of diesel injector with neutron imaging

NASA Astrophysics Data System (ADS)

Lehmann, E.; Grünzweig, C.; Jollet, S.; Kaiser, M.; Hansen, H.; Dinkelacker, F.

2015-12-01

The injection process of diesel engines influences the pollutant emissions. The spray formation is significantly influenced by the internal flow of the injector. One of the key parameters here is the generation of cavitation caused by the geometry and the needle lift. In modern diesel engines the injection pressure is established up to 3000 bar. The details of the flow and phase change processes inside the injector are of increasing importance for such injectors. With these experimental measurements the validation of multiphase and cavitation models is possible for the high pressure range. Here, for instance, cavitation effects can occur. Cavitation effects in the injection port area destabilize the emergent fuel jet and improve the jet break-up. The design of the injection system in direct-injection diesel engines is an important challenge, as the jet breakup, the atomization and the mixture formation in the combustion chamber are closely linked. These factors have a direct impact on emissions, fuel consumption and performance of an engine. The shape of the spray at the outlet is determined by the internal flow of the nozzle. Here, geometrical parameters, the injection pressure, the injection duration and the cavitation phenomena play a major role. In this work, the flow dependency in the nozzles are analysed with the Neutron-Imaging. The great advantage of this method is the penetrability of the steel structure while a high contrast to the fuel is given due to the interaction of the neutrons with the hydrogen amount. Compared to other methods (optical with glass structures) we can apply real components under highest pressure conditions. During the steady state phase of the injection various cavitation phenomena are visible in the injector, being influenced by the nozzle geometry and the fuel pressure. Different characteristics of cavitation in the sac and spray hole can be detected, and the spray formation in the primary breakup zone is influenced.

Revisiting ocean carbon sequestration by direct injection: A global carbon budget perspective Fabian Reith, David P. Keller & Andreas Oschlies

NASA Astrophysics Data System (ADS)

Reith, F.; Keller, D. P.; Martin, T.; Oschlies, A.

2015-12-01

Marchetti [1977] proposed that CO2 could be directly injected into the deep ocean to mitigate its rapid build-up in the atmosphere. Although previous studies have investigated biogeochemical and climatic effects of injecting CO2 into the ocean, they have not looked at global carbon cycle feedbacks and backfluxes that are important for accounting. Using an Earth System Model of intermediate complexity we simulated the injection of CO2 into the deep ocean during a high CO2 emissions scenario. At seven sites 0.1 GtC yr-1 was injected at three different depths (3 separate experiments) between the years 2020 and 2120. After the 100-year injection period, our simulations continued until the year 3020 to assess the long-term dynamics. In addition, we investigated the effects of marine sediment feedbacks during the experiments by running the model with and without a sediment sub-model. Our results, in regards to efficiency (the residence time of injected CO2) and seawater chemistry changes, are similar to previous studies. However, from a carbon budget perspective the targeted cumulative atmospheric CO2 reduction of 70 GtC was never reached. This was caused by the atmosphere-to-terrestrial and/or atmosphere-to-ocean carbon fluxes (relative to the control run), which were effected by the reduction in atmospheric carbon. With respect to global oceanic carbon, the respective carbon cycle-climate feedbacks led to an even smaller efficiency than indicated by tracing the injected CO2. The ocean also unexpectedly took up carbon after the injection at 1500 m was stopped because of a deep convection event in the Southern Ocean. These findings highlighted that the accounting of CO2 injection would be challenging.

Applications technology satellite advanced missions study, volume 1

NASA Technical Reports Server (NTRS)

Robinson, D. L.

1972-01-01

Four different spacecraft configurations were developed for geostationary service as a high power communications satellite. The first configuration is a Thor-Delta launch into a low orbit with a spiral ascent to synchronous altitude by ion engine propulsion. The spacecraft is earth oriented with rotating solar arrays. Configuration 2 is a direct injection Atlas/Centaur/Burner II vehicle which when in orbit is sun-oriented with a rotating transponder tower. Configurations 3 and 4 are Titan IIIC launches, and are therefore larger and heavier than Configuration 2. They are both sun-oriented, with rotating transponder towers and are directly injected into orbit. Technology discussed includes high power (up to 2 kW) transmitters with collectors radiating heat directly into space, and contoured antenna patterns designed to illuminate particular earth regions. There is also a review of potential users of the services which can be performed by this type satellite in such areas as information networking, public broadcasting and educational television.

Analysis of Fuel Injection and Atomization of a Hybrid Air-Blast Atomizer.

NASA Astrophysics Data System (ADS)

Ma, Peter; Esclape, Lucas; Buschhagen, Timo; Naik, Sameer; Gore, Jay; Lucht, Robert; Ihme, Matthias

2015-11-01

Fuel injection and atomization are of direct importance to the design of injector systems in aviation gas turbine engines. Primary and secondary breakup processes have significant influence on the drop-size distribution, fuel deposition, and flame stabilization, thereby directly affecting fuel conversion, combustion stability, and emission formation. The lack of predictive modeling capabilities for the reliable characterization of primary and secondary breakup mechanisms is still one of the main issues in improving injector systems. In this study, an unstructured Volume-of-Fluid method was used in conjunction with a Lagrangian-spray framework to conduct high-fidelity simulations of the breakup and atomization processes in a realistic gas turbine hybrid air blast atomizer. Results for injection with JP-8 aviation fuel are presented and compared to available experimental data. Financial support through the FAA National Jet Fuel Combustion Program is gratefully acknowledged.

Shock Tunnel Studies of Scramjet Phenomena

NASA Technical Reports Server (NTRS)

Stalker, R. J.

1996-01-01

Work focussed on a large number of preliminary studies of supersonic combustion in a simple combustion duct - thrust nozzle combination, investigating effects of Mach number, equivalence ratio, combustor divergence, fuel injecting angle and other parameters with an influence on the combustion process. This phase lasted for some three or four years, during which strongest emphasis was placed on responding to the request for preliminary experimental information on high enthalpy effects, to support the technology maturation activities of the NASP program. As the need for preliminary data became less urgent, it was possible to conduct more systematic studies of high enthalpy combustion phenomena, and to initiate other projects aimed at improving the facilities and instrumentation used for studying scramjet phenomena at high enthalpies. The combustion studies were particularly directed towards hypersonic combustion, and to the effects of injecting fuel along the combustion chamber wall. A substantial effort was directed towards a study of the effect of scale on the supersonic combustion process. The influence of wave phenomena (both compression waves and expansion waves) on the realization of thrust from a supersonic combustion process was also investigated. The effect of chemical kinetics was looked into, particularly as it affected the composition of the test flow provided by a ground facility. The effect of injection of the fuel through wall orifices was compared with injection from a strut spanning the stream, and the effect of heating the fuel prior to injection was investigated. Studies of fuel-air mixing by shock impingement were also done, as well as mass spectrometer surveys of a combustion wake. The use of hypersonic nozzles with an expansion tube was investigated. A new method was developed for measuring the forces acting of a model in less than one millisecond. Also included in this report are listings of published journal papers and conference presentations.

Neurotensin inversely modulates maternal aggression

PubMed Central

Gammie, Stephen C.; D’Anna, Kimberly L.; Gerstein, Hilary; Stevenson, Sharon A.

2008-01-01

Neurotensin (NT) is a versatile neuropeptide involved in analgesia, hypothermia, and schizophrenia. Although NT is released from and acts upon brain regions involved in social behaviors, it has not been linked to a social behavior. We previously selected mice for high maternal aggression (maternal defense), an important social behavior that protects offspring, and found significantly lower NT expression in the CNS of highly protective females. Our current study directly tested NT’s role in maternal defense. Intracerebroventricular (icv) injections of NT significantly impaired defense in terms of time aggressive and number of attacks at all doses tested (0.05, 0.1, 1.0, and 3.0 μg). Other maternal behaviors, including pup retrieval, were unaltered following NT injections (0.05 μg) relative to vehicle, suggesting specificity of NT action on defense. Further, icv injections of the NT receptor 1 (NT1) antagonist, SR 48692 (30 μg), significantly elevated maternal aggression in terms of time aggressive and attack number. To understand where NT may regulate aggression, we examined Fos following injection of either 0.1 μg NT or vehicle. 13 of 26 brain regions examined exhibited significant Fos increases with NT, including regions expressing NT1 and previously implicated in maternal aggression, such as lateral septum, bed nucleus of stria terminalis, paraventricular nucleus, and central amygdala. Together, our results indicate that NT inversely regulates maternal aggression and provide the first direct evidence that lowering of NT signaling can be a mechanism for maternal aggression. To our knowledge, this is the first study to directly link NT to a social behavior. PMID:19118604

Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue.

PubMed

Weil, Marie-Theres; Ruhwedel, Torben; Möbius, Wiebke; Simons, Mikael

2017-01-03

Intracerebral injections are an invasive method to bypass the blood brain barrier and are widely used to study molecular and cellular mechanisms of the central nervous system. The administered substances are injected directly at the site of interest, executing their effect locally. By combining injections in the rat brain with state-of-the-art electron microscopy, subtle changes in ultrastructure of the nervous tissue can be detected prior to overt damage or disease. The protocol presented here involves stereotactic injection into the corpus callosum of Lewis rats and the cryopreparation of freshly dissected tissue for electron microscopy. The localization of the injection site in tissue sections during the sample preparation for transmission electron microscopy is explained and possible artifacts of the method are indicated. With the help of this powerful combination of injections and electron microscopy, subtle effects of the applied substances on the biology of neural cells can be identified and monitored over time. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

Fuel Combustion Laboratory | Transportation Research | NREL

Science.gov Websites

detection of compounds at sub-parts per billion by volume levels. A high-performance liquid chromatograph ) platform; a high-pressure (1,200- bar) direct-injection system to minimize spray physics effects; and an combustion chamber. A high-speed pressure transducer measures chamber pressure to detect fuel ignition. Air

Revisiting ocean carbon sequestration by direct injection: a global carbon budget perspective

NASA Astrophysics Data System (ADS)

Reith, Fabian; Keller, David P.; Oschlies, Andreas

2016-11-01

In this study we look beyond the previously studied effects of oceanic CO2 injections on atmospheric and oceanic reservoirs and also account for carbon cycle and climate feedbacks between the atmosphere and the terrestrial biosphere. Considering these additional feedbacks is important since backfluxes from the terrestrial biosphere to the atmosphere in response to reducing atmospheric CO2 can further offset the targeted reduction. To quantify these dynamics we use an Earth system model of intermediate complexity to simulate direct injection of CO2 into the deep ocean as a means of emissions mitigation during a high CO2 emission scenario. In three sets of experiments with different injection depths, we simulate a 100-year injection period of a total of 70 GtC and follow global carbon cycle dynamics over another 900 years. In additional parameter perturbation runs, we varied the default terrestrial photosynthesis CO2 fertilization parameterization by ±50 % in order to test the sensitivity of this uncertain carbon cycle feedback to the targeted atmospheric carbon reduction through direct CO2 injections. Simulated seawater chemistry changes and marine carbon storage effectiveness are similar to previous studies. As expected, by the end of the injection period avoided emissions fall short of the targeted 70 GtC by 16-30 % as a result of carbon cycle feedbacks and backfluxes in both land and ocean reservoirs. The target emissions reduction in the parameter perturbation simulations is about 0.2 and 2 % more at the end of the injection period and about 9 % less to 1 % more at the end of the simulations when compared to the unperturbed injection runs. An unexpected feature is the effect of the model's internal variability of deep-water formation in the Southern Ocean, which, in some model runs, causes additional oceanic carbon uptake after injection termination relative to a control run without injection and therefore with slightly different atmospheric CO2 and climate. These results of a model that has very low internal climate variability illustrate that the attribution of carbon fluxes and accounting for injected CO2 may be very challenging in the real climate system with its much larger internal variability.

Slurry atomizer for a coal-feeder and dryer used to provide coal at gasifier pressure

DOEpatents

Loth, John L.; Smith, William C.; Friggens, Gary R.

1982-01-01

The present invention is directed to a coal-water slurry atomizer for use a high-pressure dryer employed in a pumping system utilized to feed coal into a pressurized coal gasifier. The slurry atomizer is provided with a venturi, constant area slurry injection conduit, and a plurality of tangentially disposed steam injection ports. Superheated steam is injected into the atomizer through these ports to provide a vortical flow of the steam, which, in turn, shears slurry emerging from the slurry injection conduit. The droplets of slurry are rapidly dispersed in the dryer through the venturi where the water is vaporized from the slurry by the steam prior to deleterious heating of the coal.

Tunnel-injected sub 290 nm ultra-violet light emitting diodes with 2.8% external quantum efficiency

NASA Astrophysics Data System (ADS)

Zhang, Yuewei; Jamal-Eddine, Zane; Akyol, Fatih; Bajaj, Sanyam; Johnson, Jared M.; Calderon, Gabriel; Allerman, Andrew A.; Moseley, Michael W.; Armstrong, Andrew M.; Hwang, Jinwoo; Rajan, Siddharth

2018-02-01

We report on the high efficiency tunnel-injected ultraviolet light emitting diodes (UV LEDs) emitting at 287 nm. Deep UV LED performance has been limited by the severe internal light absorption in the p-type contact layers and low electrical injection efficiency due to poor p-type conduction. In this work, a polarization engineered Al0.65Ga0.35N/In0.2Ga0.8N tunnel junction layer is adopted for non-equilibrium hole injection to replace the conventionally used direct p-type contact. A reverse-graded AlGaN contact layer is further introduced to realize a low resistance contact to the top n-AlGaN layer. This led to the demonstration of a low tunnel junction resistance of 1.9 × 10-3 Ω cm2 obtained at 1 kA/cm2. Light emission at 287 nm with an on-wafer peak external quantum efficiency of 2.8% and a wall-plug efficiency of 1.1% was achieved. The measured power density at 1 kA/cm2 was 54.4 W/cm2, confirming the efficient hole injection through interband tunneling. With the benefits of the minimized internal absorption and efficient hole injection, a tunnel-injected UV LED structure could enable future high efficiency UV emitters.

4 Gbps direct modulation of 450 nm GaN laser for high-speed visible light communication.

PubMed

Lee, Changmin; Zhang, Chong; Cantore, Michael; Farrell, Robert M; Oh, Sang Ho; Margalith, Tal; Speck, James S; Nakamura, Shuji; Bowers, John E; DenBaars, Steven P

2015-06-15

We demonstrate high-speed data transmission with a commercial high power GaN laser diode at 450 nm. 2.6 GHz bandwidth was achieved at an injection current of 500 mA using a high-speed visible light communication setup. Record high 4 Gbps free-space data transmission rate was achieved at room temperature.

Theoretical studies on a new pattern of laser-driven systems: towards elucidation of direct photo-injection in dye-sensitized solar cells

NASA Astrophysics Data System (ADS)

Mishima, Kenji; Yamashita, Koichi

2011-03-01

We theoretically and numerically investigated a new type of analytically solvable laser-driven systems inspired by electron-injection dynamics in dye-sensitized solar cells. The simple analytical expressions were found to be useful for understanding the difference between dye excitation and direct photo-injection occurring between dye molecule and semiconductor nanoparticles. More importantly, we propose a method for discriminating experimentally dye excitation and direct photo-injection by using time-dependent fluorescence. We found that dye excitation shows no significant quantum beat whereas the direct photo-injection shows a significant quantum beat. This work was supported by Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST) ``Development of Organic Photovoltaics toward a Low-Carbon Society,'' Cabinet Office, Japan.

Frequency division multiplexed radio-over-fiber transmission using an optically injected laser diode

NASA Astrophysics Data System (ADS)

Chan, Sze-Chun

2008-04-01

Nonlinear dynamics of semiconductor lasers have recently attracted much attention in the area of microwave photonics. By invoking the nonlinear dynamics of an optically injected laser diode, high-speed microwave oscillation can be generated using the period-one oscillation state. The oscillation is harnessed for application as a photonic microwave source in radio-over-fiber (RoF) systems. It is advantageous over conventional direct current modulation because it alleviates the modulation bandwidth limitation and naturally generates single sideband signals. The method is thus applicable to wireless communication systems even when the subcarrier frequency increases to 60 GHz. Because RoF is usually incorporated with standard wireless schemes that involve frequency division multiplexing (FDM), we investigate the performance of the optical injection system under simultaneous current injection of multiple data streams. Frequency mixings and competition for locking among subcarriers result in intermodulation distortion (IMD). The relative weightings of different channels should be optimized to ensure acceptable signal qualities. The results illustrate the feasibility of applying the optical injection system for FDM RoF transmission at high subcarrier frequencies.

Dry low NOx combustion system with pre-mixed direct-injection secondary fuel nozzle

DOEpatents

Zuo, Baifang; Johnson, Thomas; Ziminsky, Willy; Khan, Abdul

2013-12-17

A combustion system includes a first combustion chamber and a second combustion chamber. The second combustion chamber is positioned downstream of the first combustion chamber. The combustion system also includes a pre-mixed, direct-injection secondary fuel nozzle. The pre-mixed, direct-injection secondary fuel nozzle extends through the first combustion chamber into the second combustion chamber.

Sector Tests of a Low-NO(sub x), Lean, Direct- Injection, Multipoint Integrated Module Combustor Concept Conducted

NASA Technical Reports Server (NTRS)

Tacina, Robert R.; Wey, Chang-Lie; Laing, Peter; Mansour, Adel

2002-01-01

The low-emissions combustor development described is directed toward advanced high pressure aircraft gas-turbine applications. The emphasis of this research is to reduce nitrogen oxides (NOx) at high-power conditions and to maintain carbon monoxide and unburned hydrocarbons at their current low levels at low power conditions. Low-NOx combustors can be classified into rich-burn and lean-burn concepts. Lean-burn combustors can be further classified into lean-premixed-prevaporized (LPP) and lean direct injection (LDI) concepts. In both concepts, all the combustor air, except for liner cooling flow, enters through the combustor dome so that the combustion occurs at the lowest possible flame temperature. The LPP concept has been shown to have the lowest NOx emissions, but for advanced high-pressure-ratio engines, the possibility of autoignition or flashback precludes its use. LDI differs from LPP in that the fuel is injected directly into the flame zone, and thus, it does not have the potential for autoignition or flashback and should have greater stability. However, since it is not premixed and prevaporized, good atomization is necessary and the fuel must be mixed quickly and uniformly so that flame temperatures are low and NOx formation levels are comparable to those of LPP. The LDI concept described is a multipoint fuel injection/multiburning zone concept. Each of the multiple fuel injectors has an air swirler associated with it to provide quick mixing and a small recirculation zone for burning. The multipoint fuel injection provides quick, uniform mixing and the small multiburning zones provide for reduced burning residence time, resulting in low NOx formation. An integrated-module approach was used for the construction where chemically etched laminates, diffusion bonded together, combine the fuel injectors, air swirlers, and fuel manifold into a single element. The multipoint concept combustor was demonstrated in a 15 sector test. The configuration tested had 36 fuel injectors and fuel-air mixers that replaced two fuel injectors in a conventional dual-annular combustor. During tests, inlet temperatures were up to 870 K and inlet pressures were up to 5400 kPa. A correlation was developed that related the NOx emissions with the inlet temperature, inlet pressure, fuel-air ratio, and pressure drop. At low-power conditions, fuel staging was used so that high combustion efficiency was obtained with only one-fourth of the fuel injectors flowing. The test facility had optical access, and visual images showed the flame to be very short, approximately 25 mm long.

Direct Gallbladder Indocyanine Green Injection Fluorescence Cholangiography During Laparoscopic Cholecystectomy.

PubMed

Graves, Claire; Ely, Sora; Idowu, Olajire; Newton, Christopher; Kim, Sunghoon

2017-10-01

Intravenous injection of indocyanine green (ICG) is used to illuminate extrahepatic biliary anatomy. Fluorescence of biliary structures may lower surgical complications that can arise due to inadvertent injury to the common bile duct. We describe a method of injecting ICG directly into the gallbladder to define the cystic duct and common bile duct anatomy. A standard laparoscopic cholecystectomy was performed using a laparoscope with near-infrared imaging capability. Before dissection, the gallbladder was punctured with a cholangiogram catheter or a pigtail catheter to aspirate the bile within the gallbladder. The aspirated bile is mixed with ICG solution, which is reinjected into the gallbladder to fluoresce the gallbladder, cystic duct, and common bile duct structures. Eleven patients underwent direct gallbladder ICG injection for fluorescence cholangiography during cholecystectomy. Direct gallbladder ICG injection clearly defined the extrahepatic biliary anatomy, including the cystic duct-common bile duct junction, by fluorescence. In addition, the dissection plane between the gallbladder and the liver is highlighted with the gallbladder ICG fluorescence. Direct gallbladder ICG injection provides immediate visualization of extrahepatic biliary structures and clarifies the dissection plane between the gallbladder and the liver bed.

Impulsive Injection for Compressor Stator Separation Control

NASA Technical Reports Server (NTRS)

Culley, Dennis E.; Braunscheidel, Edward P.; Bright, Michelle M.

2005-01-01

Flow control using impulsive injection from the suction surface of a stator vane has been applied in a low speed axial compressor. Impulsive injection is shown to significantly reduce separation relative to steady injection for vanes that were induced to separate by an increase in vane stagger angle of 4 degrees. Injected flow was applied to the airfoil suction surface using spanwise slots pitched in the streamwise direction. Injection was limited to the near-hub region, from 10 to 36 percent of span, to affect the dominant loss due to hub leakage flow. Actuation was provided externally using high-speed solenoid valves closely coupled to the vane tip. Variations in injected mass, frequency, and duty cycle are explored. The local corrected total pressure loss across the vane at the lower span region was reduced by over 20 percent. Additionally, low momentum fluid migrating from the hub region toward the tip was effectively suppressed resulting in an overall benefit which reduced corrected area averaged loss through the passage by 4 percent. The injection mass fraction used for impulsive actuation was typically less than 0.1 percent of the compressor through flow.

Effect of Moderate Air Flow on the Distribution of Fuel Sprays After Injection Cut-0ff

NASA Technical Reports Server (NTRS)

Rothrock, A M; Spencer, R C

1935-01-01

High-speed motion pictures were taken of fuel sprays with the NACA spray-photographic apparatus to study the distribution of the liquid fuel from the instant of injection cut-off until about 0.05 second later. The fuel was injected into a glass-walled chamber in which the air density was varied from 1 to 13 times atmospheric air density (0.0765 to 0.99 pound per cubic foot) and in which the air was at room temperature. The air in the chamber was set in motion by means of a fan, and was directed counter to the spray at velocities up to 27 feet per second. The injection pressure was varied from 2,000 to 6,000 pounds per square inch. A 0.20-inch single-orifice nozzle, an 0.008-inch single-orifice nozzle, a multiorifice nozzle, and an impinging-jets nozzle were used. The best distribution was obtained by the use of air and a high-dispersion nozzle.

Scale Model Test and Transient Analysis of Steam Injector Driven Passive Core Injection System for Innovative-Simplified Nuclear Power Plant

NASA Astrophysics Data System (ADS)

Ohmori, Shuichi; Narabayashi, Tadashi; Mori, Michitsugu

A steam injector (SI) is a simple, compact and passive pump and also acts as a high-performance direct-contact compact heater. This provides SI with capability to serve also as a direct-contact feed-water heater that heats up feed-water by using extracted steam from turbine. Our technology development aims to significantly simplify equipment and reduce physical quantities by applying "high-efficiency SI", which are applicable to a wide range of operation regimes beyond the performance and applicable range of existing SIs and enables unprecedented multistage and parallel operation, to the low-pressure feed-water heaters and emergency core cooling system of nuclear power plants, as well as achieve high inherent safety to prevent severe accidents by keeping the core covered with water (a severe accident-free concept). This paper describes the results of the scale model test, and the transient analysis of SI-driven passive core injection system (PCIS).

Premixed direct injection disk

DOEpatents

York, William David; Ziminsky, Willy Steve; Johnson, Thomas Edward; Lacy, Benjamin; Zuo, Baifang; Uhm, Jong Ho

2013-04-23

A fuel/air mixing disk for use in a fuel/air mixing combustor assembly is provided. The disk includes a first face, a second face, and at least one fuel plenum disposed therebetween. A plurality of fuel/air mixing tubes extend through the pre-mixing disk, each mixing tube including an outer tube wall extending axially along a tube axis and in fluid communication with the at least one fuel plenum. At least a portion of the plurality of fuel/air mixing tubes further includes at least one fuel injection hole have a fuel injection hole diameter extending through said outer tube wall, the fuel injection hole having an injection angle relative to the tube axis. The invention provides good fuel air mixing with low combustion generated NOx and low flow pressure loss translating to a high gas turbine efficiency, that is durable, and resistant to flame holding and flash back.

Observing Exoplanets with High-dispersion Coronagraphy. II. Demonstration of an Active Single-mode Fiber Injection Unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mawet, D.; Ruane, G.; Xuan, W.

2017-04-01

High-dispersion coronagraphy (HDC) optimally combines high-contrast imaging techniques such as adaptive optics/wavefront control plus coronagraphy to high spectral resolution spectroscopy. HDC is a critical pathway toward fully characterizing exoplanet atmospheres across a broad range of masses from giant gaseous planets down to Earth-like planets. In addition to determining the molecular composition of exoplanet atmospheres, HDC also enables Doppler mapping of atmosphere inhomogeneities (temperature, clouds, wind), as well as precise measurements of exoplanet rotational velocities. Here, we demonstrate an innovative concept for injecting the directly imaged planet light into a single-mode fiber, linking a high-contrast adaptively corrected coronagraph to a high-resolutionmore » spectrograph (diffraction-limited or not). Our laboratory demonstration includes three key milestones: close-to-theoretical injection efficiency, accurate pointing and tracking, and on-fiber coherent modulation and speckle nulling of spurious starlight signal coupling into the fiber. Using the extreme modal selectivity of single-mode fibers, we also demonstrated speckle suppression gains that outperform conventional image-based speckle nulling by at least two orders of magnitude.« less

Observing Exoplanets with High-dispersion Coronagraphy. II. Demonstration of an Active Single-mode Fiber Injection Unit

NASA Astrophysics Data System (ADS)

Mawet, D.; Ruane, G.; Xuan, W.; Echeverri, D.; Klimovich, N.; Randolph, M.; Fucik, J.; Wallace, J. K.; Wang, J.; Vasisht, G.; Dekany, R.; Mennesson, B.; Choquet, E.; Delorme, J.-R.; Serabyn, E.

2017-04-01

High-dispersion coronagraphy (HDC) optimally combines high-contrast imaging techniques such as adaptive optics/wavefront control plus coronagraphy to high spectral resolution spectroscopy. HDC is a critical pathway toward fully characterizing exoplanet atmospheres across a broad range of masses from giant gaseous planets down to Earth-like planets. In addition to determining the molecular composition of exoplanet atmospheres, HDC also enables Doppler mapping of atmosphere inhomogeneities (temperature, clouds, wind), as well as precise measurements of exoplanet rotational velocities. Here, we demonstrate an innovative concept for injecting the directly imaged planet light into a single-mode fiber, linking a high-contrast adaptively corrected coronagraph to a high-resolution spectrograph (diffraction-limited or not). Our laboratory demonstration includes three key milestones: close-to-theoretical injection efficiency, accurate pointing and tracking, and on-fiber coherent modulation and speckle nulling of spurious starlight signal coupling into the fiber. Using the extreme modal selectivity of single-mode fibers, we also demonstrated speckle suppression gains that outperform conventional image-based speckle nulling by at least two orders of magnitude.

A simple dual online ultra-high pressure liquid chromatography system (sDO-UHPLC) for high throughput proteome analysis.

PubMed

Lee, Hangyeore; Mun, Dong-Gi; Bae, Jingi; Kim, Hokeun; Oh, Se Yeon; Park, Young Soo; Lee, Jae-Hyuk; Lee, Sang-Won

2015-08-21

We report a new and simple design of a fully automated dual-online ultra-high pressure liquid chromatography system. The system employs only two nano-volume switching valves (a two-position four port valve and a two-position ten port valve) that direct solvent flows from two binary nano-pumps for parallel operation of two analytical columns and two solid phase extraction (SPE) columns. Despite the simple design, the sDO-UHPLC offers many advantageous features that include high duty cycle, back flushing sample injection for fast and narrow zone sample injection, online desalting, high separation resolution and high intra/inter-column reproducibility. This system was applied to analyze proteome samples not only in high throughput deep proteome profiling experiments but also in high throughput MRM experiments.

Apparatus for providing directional permeability measurements in subterranean earth formations

DOEpatents

Shuck, Lowell Z.

1977-01-01

Directional permeability measurements are provided in a subterranean earth formation by injecting a high-pressure gas from a wellbore into the earth formation in various azimuthal directions with the direction having the largest pressure drop being indicative of the maximum permeability direction. These measurements are provided by employing an inflatable boot containing a plurality of conduits in registry with a like plurality of apertures penetrating the housing at circumferentially spaced-apart locations. These conduits are, in turn, coupled through a valved manifold to a source of pressurized gas so that the high-pressure gas may be selectively directed through any conduit into the earth formation defining the bore with the resulting difference in the pressure drop through the various conduits providing the permeability measurements.

QUANTITATIVE ANALYSIS OF 68 POLAR COMPOUNDS FROM TEN CHEMICAL CLASSES BY DIRECT AQUEOUS INJECTION GAS CHROMATOGRAPHY

EPA Science Inventory

Porous polymer packings have been used successfully in many applications of direct aqueous injection gas chromatography. The authors have expanded the use of aqueous injection to the quantitative analysis of 68 alcohols, acetates, ketones, ethers, sulfides, aldehydes, diols, dion...

Method for minimizing decarburization and other high temperature oxygen reactions in a plasma sprayed material

DOEpatents

Lenling, William J.; Henfling, Joseph A.; Smith, Mark F.

1993-06-08

A method is disclosed for spray coating material which employs a plasma gun that has a cathode, an anode, an arc gas inlet, a first powder injection port, and a second powder injection port. A suitable arc gas is introduced through the arc gas inlet, and ionization of the arc gas between the cathode and the anode forms a plasma. The plasma is directed to emenate from an open-ended chamber defined by the boundary of the anode. A coating is deposited upon a base metal part by suspending a binder powder within a carrier gas that is fed into the plasma through the first powder injection port; a material subject to degradation by high temperature oxygen reactions is suspended within a carrier gas that is fed into the plasma through the second injection port. The material fed through the second injection port experiences a cooler portion of the plasma and has a shorter dwell time within the plasma to minimize high temperature oxygen reactions. The material of the first port and the material of the second port intermingle within the plasma to form a uniform coating having constituent percentages related to the powder-feed rates of the materials through the respective ports.

Micellar electrokinetic chromatography and capillary electrochromatography of nitroaromatic explosives in seawater.

PubMed

Giordano, Braden C; Copper, Christine L; Collins, Greg E

2006-02-01

The ability to separate nitroaromatic and nitramine explosives in seawater sample matrices is demonstrated using both MEKC and CEC. While several capillary-based separations exist for explosives, none address direct sampling from seawater, a sample matrix of particular interest in the detection of undersea mines. Direct comparisons are made between MEKC and CEC in terms of sensitivity and separation efficiency for the analysis of 14 explosives and explosive degradation products in seawater and diluted seawater. The use of high-salt stacking with MEKC results, on average, in a three-fold increase in the number of theoretical plates, and nearly double resolution for samples prepared in 25% seawater. By taking advantage of long injection times in conjunction with stacking, detection limits down to sub mg/L levels are attainable; however, resolution is sacrificed. CEC of explosive mixtures using sol-gels prepared from methyltrimethoxysilane does not perform as well as MEKC in terms of resolving power, but does permit extended injection times for concentrating analyte onto the head of the separation column with little or no subsequent loss in resolution. Electrokinetic injections of 8 min at high voltage allow for detection limits of explosives below 100 microg/L.

Intra-Arterial Delivery of AAV Vectors to the Mouse Brain After Mannitol Mediated Blood Brain Barrier Disruption

PubMed Central

Santillan, Alejandro; Sondhi, Dolan; Dyke, Jonathan P.; Crystal, Ronald G.; Gobin, Y. Pierre; Ballon, Douglas J.

2014-01-01

The delivery of therapeutics to neural tissue is greatly hindered by the blood brain barrier (BBB). Direct local delivery via diffusive release from degradable implants or direct intra-cerebral injection can bypass the BBB and obtain high concentrations of the therapeutic in the targeted tissue, however the total volume of tissue that can be treated using these techniques is limited. One treatment modality that can potentially access large volumes of neural tissue in a single treatment is intra-arterial (IA) injection after osmotic blood brain barrier disruption. In this technique, the therapeutic of interest is injected directly into the arteries that feed the target tissue after the blood brain barrier has been disrupted by exposure to a hyperosmolar mannitol solution, permitting the transluminal transport of the therapy. In this work we used contrast enhanced magnetic resonance imaging (MRI) studies of IA injections in mice to establish parameters that allow for extensive and reproducible BBB disruption. We found that the volume but not the flow rate of the mannitol injection has a significant effect on the degree of disruption. To determine whether the degree of disruption we observed with this method was sufficient for delivery of nanoscale therapeutics, we performed IA injections of an adeno-associated viral vector containing the CLN2 gene (AAVrh.10CLN2), which is mutated in the lysosomal storage disorder Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL). We demonstrated that IA injection of AAVrh.10CLN2 after BBB disruption can achieve widespread transgene production in the mouse brain after a single administration. Further, we showed that there exists a minimum threshold of BBB disruption necessary to permit the AAV.rh10 vector to pass into the brain parenchyma from the vascular system. These results suggest that IA administration may be used to obtain widespread delivery of nanoscale therapeutics throughout the murine brain after a single administration. PMID:25270115

Needle Tip Position and Bevel Direction Have No Effect in the Fluoroscopic Epidural Spreading Pattern in Caudal Epidural Injections: A Randomized Trial

PubMed Central

Kwon, Won Kyoung; Kim, Ah Na; Lee, Pil Moo; Park, Cheol Hwan; Kim, Jae Hun

2016-01-01

Background. Caudal epidural steroid injections (CESIs) are an effective treatment for pain. If the injection spreads in a specific pattern depending on the needle position or bevel direction, it would be possible to inject the agent into a specific and desired area. Objectives. We conducted a prospective randomized trial to determine if the needle position and bevel direction have any effect on the epidural spreading pattern in CESI. Methods. Demographic data of the patient were collected. During CESI, the needle position (middle or lateral) and direction (ventral or dorsal) were randomly allocated. Following fluoroscope-guided injection of 4 mL contrast media and 10 mL of injectates, the epidural spreading patterns (ventral or dorsal, bilateral or lateral) were imaged. Results. In the 210 CESIs performed, the needle tip position and bevel direction did not influence the epidural spreading patterns at L4-5 and L5-S1 disc levels. A history of Lumbar spine surgery was associated with a significantly limited spread to each disc level. A midline needle tip position was more effective than the lateral position in spreading to the distant disc levels. Conclusions. Neither the needle tip position nor the bevel direction affected the epidural drug spreading pattern during CESI. PMID:27445609

A HWIL test facility of infrared imaging laser radar using direct signal injection

NASA Astrophysics Data System (ADS)

Wang, Qian; Lu, Wei; Wang, Chunhui; Wang, Qi

2005-01-01

Laser radar has been widely used these years and the hardware-in-the-loop (HWIL) testing of laser radar become important because of its low cost and high fidelity compare with On-the-Fly testing and whole digital simulation separately. Scene generation and projection two key technologies of hardware-in-the-loop testing of laser radar and is a complicated problem because the 3D images result from time delay. The scene generation process begins with the definition of the target geometry and reflectivity and range. The real-time 3D scene generation computer is a PC based hardware and the 3D target models were modeled using 3dsMAX. The scene generation software was written in C and OpenGL and is executed to extract the Z-buffer from the bit planes to main memory as range image. These pixels contain each target position x, y, z and its respective intensity and range value. Expensive optical injection technologies of scene projection such as LDP array, VCSEL array, DMD and associated scene generation is ongoing. But the optical scene projection is complicated and always unaffordable. In this paper a cheaper test facility was described that uses direct electronic injection to provide rang images for laser radar testing. The electronic delay and pulse shaping circuits inject the scenes directly into the seeker's signal processing unit.

Numerical investigation of liver radioembolization via computational particle-hemodynamics: The role of the microcatheter distal direction and microsphere injection point and velocity.

PubMed

Aramburu, Jorge; Antón, Raúl; Rivas, Alejandro; Ramos, Juan Carlos; Sangro, Bruno; Bilbao, José Ignacio

2016-11-07

Liver radioembolization is a treatment option for patients with primary and secondary liver cancer. The procedure consists of injecting radiation-emitting microspheres via an intra-arterially placed microcatheter, enabling the deposition of the microspheres in the tumoral bed. The microcatheter location and the particle injection rate are determined during a pretreatment work-up. The purpose of this study was to numerically study the effects of the injection characteristics during the first stage of microsphere travel through the bloodstream in a patient-specific hepatic artery (i.e., the near-tip particle-hemodynamics and the segment-to-segment particle distribution). Specifically, the influence of the distal direction of an end-hole microcatheter and particle injection point and velocity were analyzed. Results showed that the procedure targeted the right lobe when injecting from two of the three injection points under study and the remaining injection point primarily targeted the left lobe. Changes in microcatheter direction and injection velocity resulted in an absolute difference in exiting particle percentage for a given liver segment of up to 20% and 30%, respectively. It can be concluded that even though microcatheter placement is presumably reproduced in the treatment session relative to the pretreatment angiography, the treatment may result in undesired segment-to-segment particle distribution and therefore undesired treatment outcomes due to modifications of any of the parameters studied, i.e., microcatheter direction and particle injection point and velocity. Copyright © 2016 Elsevier Ltd. All rights reserved.

GaN Light-Emitting Triodes (LETs) for High-Efficiency Hole Injection and for Assessment of the Physical Origin of the Efficiency Droop

DTIC Science & Technology

2007-07-06

quantum efficiency . In AlGaN-based UV LEDs, an electron-blocking layer (EBL) is frequently inserted between the p-type cladding layer and the active...me). This limits the hole injection efficiency into the active region, and hence internal quantum efficiency . Figure 1: (a) Schematic band...less efficient than along the lateral direction because most of the holes ionized from the acceptors are localized inside the quantum wells which are

Dimensional Precision Research of Wax Molding Rapid Prototyping based on Droplet Injection

NASA Astrophysics Data System (ADS)

Mingji, Huang; Geng, Wu; yan, Shan

2017-11-01

The traditional casting process is complex, the mold is essential products, mold quality directly affect the quality of the product. With the method of rapid prototyping 3D printing to produce mold prototype. The utility wax model has the advantages of high speed, low cost and complex structure. Using the orthogonal experiment as the main method, analysis each factors of size precision. The purpose is to obtain the optimal process parameters, to improve the dimensional accuracy of production based on droplet injection molding.

Extravasation of radiopharmaceuticals - a study of its frequency and estimation of absorbed doses in diagnosis and therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strand, S.E.; Grafstroem, G.; Kontestabile, E.

In all injection procedures exists a risk for extravasation. For radiopharmaceuticals, the absorbed dose at the injection site can be high because of high activity concentrations. In radionuclide therapy (RNT), this can cause deterministic effects such as tissue necrosis. To estimate the risk for extravasation, we studied various injection techniques at two nuclear medicine clinics. The frequency and magnitude of extravasations was studied in randomly selected patients. Clinic A used peripheral venous cathethers (PVC), and clinic B used direct injections with injection needles (IN). At clinic A 203 patients were investigated and at clinic B 90. All of these patientsmore » were injected with either 99mTc-DTPA, 99mTc-MAA, 99mTc-MDP or pertechnetate. Both arms were imaged with a scintillation camera as soon as possible after the injection. In the case of an extravasation, the retention time at the injection site was determined with multiple imaging, together with volume estimates. The results for PVC injected patients showed one complete extravasation. We also found that in 8% of these patients the remaining activity at the injection site was up to 2%. For the IN injected patients there was none with complete extravasation. However, in 33% of these patients the remaining activity was up to 18%. The locally absorbed doses in these diagnostically investigated patients were estimated with the MIRD formalism to be up to 0.1 Sv (10 rem). Transforming these results to the RNT, the absorbed doses can be up to 1000 times higher. In addition to the calculated absorbed doses, radionuclides localizing to the cell nucleus could enhance the effects.« less

Separating inverse spin Hall voltage and spin rectification voltage by inverting spin injection direction

NASA Astrophysics Data System (ADS)

Zhang, Wenxu; Peng, Bin; Han, Fangbin; Wang, Qiuru; Soh, Wee Tee; Ong, Chong Kim; Zhang, Wanli

2016-03-01

We develop a method for universally resolving the important issue of separating the inverse spin Hall effect (ISHE) from the spin rectification effect (SRE) signal. This method is based on the consideration that the two effects depend on the spin injection direction: The ISHE is an odd function of the spin injection direction while the SRE is independent on it. Thus, the inversion of the spin injection direction changes the ISHE voltage signal, while the SRE voltage remains. It applies generally to analyzing the different voltage contributions without fitting them to special line shapes. This fast and simple method can be used in a wide frequency range and has the flexibility of sample preparation.

Droplet-based microfluidic flow injection system with large-scale concentration gradient by a single nanoliter-scale injection for enzyme inhibition assay.

PubMed

Cai, Long-Fei; Zhu, Ying; Du, Guan-Sheng; Fang, Qun

2012-01-03

We described a microfluidic chip-based system capable of generating droplet array with a large scale concentration gradient by coupling flow injection gradient technique with droplet-based microfluidics. Multiple modules including sample injection, sample dispersion, gradient generation, droplet formation, mixing of sample and reagents, and online reaction within the droplets were integrated into the microchip. In the system, nanoliter-scale sample solution was automatically injected into the chip under valveless flow injection analysis mode. The sample zone was first dispersed in the microchannel to form a concentration gradient along the axial direction of the microchannel and then segmented into a linear array of droplets by immiscible oil phase. With the segmentation and protection of the oil phase, the concentration gradient profile of the sample was preserved in the droplet array with high fidelity. With a single injection of 16 nL of sample solution, an array of droplets with concentration gradient spanning 3-4 orders of magnitude could be generated. The present system was applied in the enzyme inhibition assay of β-galactosidase to preliminarily demonstrate its potential in high throughput drug screening. With a single injection of 16 nL of inhibitor solution, more than 240 in-droplet enzyme inhibition reactions with different inhibitor concentrations could be performed with an analysis time of 2.5 min. Compared with multiwell plate-based screening systems, the inhibitor consumption was reduced 1000-fold. © 2011 American Chemical Society

Hydrodynamic injection with pneumatic valving for microchip electrophoresis with total analyte utilization

PubMed Central

Sun, Xuefei; Kelly, Ryan T.; Danielson, William F.; Agrawal, Nitin; Tang, Keqi; Smith, Richard D.

2011-01-01

A novel hydrodynamic injector that is directly controlled by a pneumatic valve has been developed for reproducible microchip capillary electrophoresis (CE) separations. The poly(dimethylsiloxane) (PDMS) devices used for evaluation comprise a separation channel, a side channel for sample introduction, and a pneumatic valve aligned at the intersection of the channels. A low pressure (≤ 3 psi) applied to the sample reservoir is sufficient to drive sample into the separation channel. The rapidly actuated pneumatic valve enables injection of discrete sample plugs as small as ~100 pL for CE separation. The injection volume can be easily controlled by adjusting the intersection geometry, the solution back pressure and the valve actuation time. Sample injection could be reliably operated at different frequencies (< 0.1 Hz to >2 Hz) with good reproducibility (peak height relative standard deviation ≤ 3.6%) and no sampling biases associated with the conventional electrokinetic injections. The separation channel was dynamically coated with a cationic polymer, and FITC-labeled amino acids were employed to evaluate the CE separation. Highly efficient (≥ 7.0 × 103 theoretical plates for the ~2.4 cm long channel) and reproducible CE separations were obtained. The demonstrated method has numerous advantages compared with the conventional techniques, including repeatable and unbiased injections, little sample waste, high duty cycle, controllable injected sample volume, and fewer electrodes with no need for voltage switching. The prospects of implementing this injection method for coupling multidimensional separations, for multiplexing CE separations and for sample-limited bioanalyses are discussed. PMID:21520147

Status of the laser ion source at IMP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sha, S.; Graduate University of Chinese Academy of Sciences, Beijing 100049; School of Nuclear science and technology, Lanzhou University, Lanzhou 73000

2012-02-15

A laser (Nd:YAG laser, 3 J, 1064 nm, 8-10 ns) ion source has been built and under development at IMP to provide pulsed high-charge-state heavy ion beams to a radio frequency quadrupole (RFQ) for upgrading the IMP accelerators with a new low-energy beam injector. The laser ion source currently operates in a direct plasma injection scheme to inject the high charge state ions produced from a solid target into the RFQ. The maximum power density on the target was about 8.4 x 10{sup 12} W/cm{sup 2}. The preliminary experimental results will be presented and discussed in this paper.

Orthogonal ion injection apparatus and process

DOEpatents

Kurulugama, Ruwan T; Belov, Mikhail E

2014-04-15

An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions.

InGaN/GaN light-emitting diode having direct hole injection plugs and its high-current operation.

PubMed

Kim, Sungjoon; Cho, Seongjae; Jeong, Jaedeok; Kim, Sungjun; Hwang, Sungmin; Kim, Garam; Yoon, Sukho; Park, Byung-Gook

2017-03-20

The light-emitting diode (LED) with an improved hole injection and straightforward process integration is proposed. p-type GaN direct hole injection plugs (DHIPs) are formed on locally etched multiple-quantum wells (MQWs) by epitaxial lateral overgrowth (ELO) method. We confirm that the optical output power is increased up to 23.2% at an operating current density of 100 A/cm². Furthermore, in order to identify the origin of improvement in optical performance, the transient light decay time and light intensity distribution characteristics were analyzed on the DHIP LED devices. Through the calculation of the electroluminescence (EL) decay time, internal quantum efficiency (IQE) is extracted along with the recombination parameters, which reveals that the DHIPs have a significant effect on enhancement of radiative recombination and reduction of efficiency droop. Furthermore, the mapping PL reveals that the DHIP LED also has a potential to improve the light extraction efficiency by hexagonal pyramid shaped DHIPs.

Optical gain in colloidal quantum dots achieved with direct-current electrical pumping

NASA Astrophysics Data System (ADS)

Lim, Jaehoon; Park, Young-Shin; Klimov, Victor I.

2018-01-01

Chemically synthesized semiconductor quantum dots (QDs) can potentially enable solution-processable laser diodes with a wide range of operational wavelengths, yet demonstrations of lasing from the QDs are still at the laboratory stage. An important challenge--realization of lasing with electrical injection--remains unresolved, largely due to fast nonradiative Auger recombination of multicarrier states that represent gain-active species in the QDs. Here we present population inversion and optical gain in colloidal nanocrystals realized with direct-current electrical pumping. Using continuously graded QDs, we achieve a considerable suppression of Auger decay such that it can be outpaced by electrical injection. Further, we apply a special current-focusing device architecture, which allows us to produce high current densities (j) up to ~18 A cm-2 without damaging either the QDs or the injection layers. The quantitative analysis of electroluminescence and current-modulated transmission spectra indicates that with j = 3-4 A cm-2 we achieve the population inversion of the band-edge states.

Controlling heat and particle currents in nanodevices by quantum observation

NASA Astrophysics Data System (ADS)

Biele, Robert; Rodríguez-Rosario, César A.; Frauenheim, Thomas; Rubio, Angel

2017-07-01

We demonstrate that in a standard thermo-electric nanodevice the current and heat flows are not only dictated by the temperature and potential gradient, but also by the external action of a local quantum observer that controls the coherence of the device. Depending on how and where the observation takes place, the direction of heat and particle currents can be independently controlled. In fact, we show that the current and heat flow in a quantum material can go against the natural temperature and voltage gradients. Dynamical quantum observation offers new possibilities for the control of quantum transport far beyond classical thermal reservoirs. Through the concept of local projections, we illustrate how we can create and directionality control the injection of currents (electronic and heat) in nanodevices. This scheme provides novel strategies to construct quantum devices with application in thermoelectrics, spintronic injection, phononics, and sensing among others. In particular, highly efficient and selective spin injection might be achieved by local spin projection techniques.

Study on the characteristic and application of DFB semiconductor lasers under optical injection for microwave photonics

NASA Astrophysics Data System (ADS)

Pu, Tao; Wang, Wei wei

2018-01-01

In order to apply optical injection effect in Microwave Photonics system, The red-shift effect of the cavity mode of the DFB semiconductor laser under single-frequency optical injection is studied experimentally, and the red-shift curve of the cavity mode is measured. The wavelength-selective amplification property of the DFB semiconductor laser under multi-frequency optical injection is also investigated, and the gain curves for the injected signals in different injection ratios are measured in the experiment. A novel and simple structure to implement a single-passband MPF with wideband tunability based on the wavelength-selective amplification of a DFB semiconductor laser under optical injection is proposed and experimentally demonstrated. MPFs with center frequency tuned from 13 to 41 GHz are realized in the experiment. A wideband and frequency-tunable optoelectronic oscillator based on a directly modulated distributed feedback (DFB) semiconductor laser under optical injection is proposed and experimentally demonstrated. By optical injection, the relaxation oscillation frequency of the DFB laser is enhanced and its high modulation efficiency makes the loop oscillate without the necessary of the electrical filter. An experiment is performed; microwave signals with frequency tuned from 5.98 to 15.22 GHz are generated by adjusting the injection ratio and frequency detuning between the master and slave lasers.

Application of an EGR system in a direct injection diesel engine to reduce NOx emissions

NASA Astrophysics Data System (ADS)

De Serio, D.; De Oliveira, A.; Sodré, J. R.

2016-09-01

This work presents the application of an exhaust gas recirculation (EGR) system in a direct injection diesel engine operating with diesel oil containing 7% biodiesel (B7). EGR rates of up to 10% were applied with the primary aim to reduce oxides of nitrogen (NOx) emissions. The experiments were conducted in a 44 kW diesel power generator to evaluate engine performance and emissions for different load settings. The use of EGR caused a peak pressure reduction during the combustion process and a decrease in thermal efficiency, mainly at high engine loads. A reduction of NOx emissions of up to 26% was achieved, though penalizing carbon monoxide (CO) and total hydrocarbons (THC) emissions.

A study of a direct-injection stratified-charge rotary engine for motor vehicle application

NASA Astrophysics Data System (ADS)

Kagawa, Ryoji; Okazaki, Syunki; Somyo, Nobuhiro; Akagi, Yuji

1993-03-01

A study of a direct-injection stratified-charge system (DISC), as applied to a rotary engine (RE) for motor vehicle usage, was undertaken. The goals of this study were improved fuel consumption and reduced exhaust emissions. These goals were thought feasible due to the high thermal efficiency associated with the DISC-RE. This was the first application of this technology to a motor vehicle engine. Stable ignition and ideal stratification systems were developed by means of numerical calculations, air-fuel mixture measurements, and actual engine tests. The use of DISC resulted in significantly improved fuel consumption and reduced exhaust emissions. The use of an exhaust gas recirculating system was studied and found to be beneficial in NOx reduction.

Isolating the effects of reactivity stratification in reactivity-controlled compression ignition with iso-octane and n-heptane on a light-duty multi-cylinder engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wissink, Martin L.; Curran, Scott J.; Roberts, Greg

Reactivity-controlled compression ignition (RCCI) is a dual-fuel variant of low-temperature combustion that uses in-cylinder fuel stratification to control the rate of reactions occurring during combustion. Using fuels of varying reactivity (autoignition propensity), gradients of reactivity can be established within the charge, allowing for control over combustion phasing and duration for high efficiency while achieving low NO x and soot emissions. In practice, this is typically accomplished by premixing a low-reactivity fuel, such as gasoline, with early port or direct injection, and by direct injecting a high-reactivity fuel, such as diesel, at an intermediate timing before top dead center. Both themore » relative quantity and the timing of the injection(s) of high-reactivity fuel can be used to tailor the combustion process and thereby the efficiency and emissions under RCCI. While many combinations of high- and low-reactivity fuels have been successfully demonstrated to enable RCCI, there is a lack of fundamental understanding of what properties, chemical or physical, are most important or desirable for extending operation to both lower and higher loads and reducing emissions of unreacted fuel and CO. This is partly due to the fact that important variables such as temperature, equivalence ratio, and reactivity change simultaneously in both a local and a global sense with changes in the injection of the high-reactivity fuel. This study uses primary reference fuels iso-octane and n-heptane, which have similar physical properties but much different autoignition properties, to create both external and in-cylinder fuel blends that allow for the effects of reactivity stratification to be isolated and quantified. This study is part of a collaborative effort with researchers at Sandia National Laboratories who are investigating the same fuels and conditions of interest in an optical engine. Furthermore, this collaboration aims to improve our fundamental understanding of what fuel properties are required to further develop advanced combustion modes.« less

Isolating the effects of reactivity stratification in reactivity-controlled compression ignition with iso-octane and n-heptane on a light-duty multi-cylinder engine

DOE PAGES

Wissink, Martin L.; Curran, Scott J.; Roberts, Greg; ...

2017-10-09

Reactivity-controlled compression ignition (RCCI) is a dual-fuel variant of low-temperature combustion that uses in-cylinder fuel stratification to control the rate of reactions occurring during combustion. Using fuels of varying reactivity (autoignition propensity), gradients of reactivity can be established within the charge, allowing for control over combustion phasing and duration for high efficiency while achieving low NO x and soot emissions. In practice, this is typically accomplished by premixing a low-reactivity fuel, such as gasoline, with early port or direct injection, and by direct injecting a high-reactivity fuel, such as diesel, at an intermediate timing before top dead center. Both themore » relative quantity and the timing of the injection(s) of high-reactivity fuel can be used to tailor the combustion process and thereby the efficiency and emissions under RCCI. While many combinations of high- and low-reactivity fuels have been successfully demonstrated to enable RCCI, there is a lack of fundamental understanding of what properties, chemical or physical, are most important or desirable for extending operation to both lower and higher loads and reducing emissions of unreacted fuel and CO. This is partly due to the fact that important variables such as temperature, equivalence ratio, and reactivity change simultaneously in both a local and a global sense with changes in the injection of the high-reactivity fuel. This study uses primary reference fuels iso-octane and n-heptane, which have similar physical properties but much different autoignition properties, to create both external and in-cylinder fuel blends that allow for the effects of reactivity stratification to be isolated and quantified. This study is part of a collaborative effort with researchers at Sandia National Laboratories who are investigating the same fuels and conditions of interest in an optical engine. Furthermore, this collaboration aims to improve our fundamental understanding of what fuel properties are required to further develop advanced combustion modes.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Zihan; Swantek, Andrew; Scarcelli, Riccardo

This paper focuses on detailed numerical simulations of direct injection diesel and gasoline sprays from production grade, multi-hole injectors. In a dual-fuel engine the direct injection of both the fuels can facilitate appropriate mixture preparation prior to ignition and combustion. Diesel and gasoline sprays were simulated using high-fidelity Large Eddy Simulations (LES) with the dynamic structure sub-grid scale model. Numerical predictions of liquid penetration, fuel density distribution as well as transverse integrated mass (TIM) at different axial locations versus time were compared against x-ray radiography data obtained from Argonne National Laboratory. A necessary, but often overlooked, criterion of grid-convergence ismore » ensured by using Adaptive Mesh Refinement (AMR) for both diesel and gasoline. Nine different realizations were performed and the effects of random seeds on spray behavior were investigated. Additional parametric studies under different ambient and injection conditions were performed to study their influence on global and local flow structures for gasoline sprays. It is concluded that LES can generally well capture all experimental trends and comes close to matching the x-ray data. Discrepancies between experimental and simulation results can be correlated to uncertainties in boundary and initial conditions such as rate of injection and spray and turbulent dispersion sub-model constants.« less

Botulinum toxin in parkinsonism: The when, how, and which for botulinum toxin injections.

PubMed

Cardoso, Francisco

2018-06-01

The aim of this article is to provide a review of the use of injections of botulinum toxin in the management of selected symptoms and signs of Parkinson's disease and other forms of parkinsonism. Sialorrhea is defined as inability to control oral secretions, resulting in excessive saliva in the oropharynx. There is a high level of evidence for the treatment of sialorrhea in parkinsonism with injections of different forms of botulinum toxin type A as well as botulinum toxin type B. Tremor can be improved by the use of botulinum toxin injections but improved tremor control often leads to concomitant motor weakness, limiting its use. Levodopa induced dyskinesias are difficult to treat with botulinum toxin injections because of their variable frequency and direction. Apraxia of eyelid opening, a sign more commonly seen in progressive supranuclear palsy and other tauopathies, often improves after botulinum toxin injections. Recent data suggest that regardless of the underlying mechanism, pain in parkinsonism can be alleviated by botulinum toxin injections. Finally, freezing of gait, camptocormia and Pisa syndrome in parkinsonism almost invariably fail to respond to botulinum toxin injections. Copyright © 2017 Elsevier Ltd. All rights reserved.

Portable device and method for determining permeability characteristics of earth formations

DOEpatents

Shuck, Lowell Z.

1977-01-01

The invention is directed to a device which is used for determining permeability characteristics of earth formations at the surface thereof. The determination of the maximum permeability direction and the magnitude of permeability are achieved by employing a device comprising a housing having a central fluid-injection port surrounded by a plurality of spaced-apart fluid flow and pressure monitoring ports radially extending from the central injection port. With the housing resting on the earth formation in a relatively fluid-tight manner as provided by an elastomeric pad disposed therebetween, fluid is injected through the central port into the earth formation and into registry with the fluid-monitoring ports disposed about the injection port. The fluid-monitoring ports are selectively opened and the flow of the fluid through the various fluid ports is measured so as to provide a measurement of flow rates and pressure distribution about the center hole which is indicative on the earth formation permeability direction and magnitude. For example, the azimuthal direction of the fluid-monitoring ports in the direction through which the greatest amount of injected fluid flows as determined by the lowest pressure distribution corresponds to the direction of maximum permeability in the earth formation.

Use of Adaptive Injection Strategies to Increase the Full Load Limit of RCCI Operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, Reed; Ickes, Andrew; Wallner, Thomas

Dual-fuel combustion using port-injection of low reactivity fuel combined with direct injection (DI) of a higher reactivity fuel, otherwise known as reactivity controlled compression ignition (RCCI), has been shown as a method to achieve low-temperature combustion with moderate peak pressure rise rates, low engine-out soot and NOx emissions, and high indicated thermal efficiency. A key requirement for extending to high-load operation is moderating the reactivity of the premixed charge prior to the diesel injection. One way to accomplish this is to use a very low reactivity fuel such as natural gas. In this work, experimental testing was conducted on amore » 13 l multicylinder heavy-duty diesel engine modified to operate using RCCI combustion with port injection of natural gas and DI of diesel fuel. Engine testing was conducted at an engine speed of 1200 rpm over a wide variety of loads and injection conditions. The impact on dual-fuel engine performance and emissions with respect to varying the fuel injection parameters is quantified within this study. The injection strategies used in the work were found to affect the combustion process in similar ways to both conventional diesel combustion (CDC) and RCCI combustion for phasing control and emissions performance. As the load is increased, the port fuel injection (PFI) quantity was reduced to keep peak cylinder pressure (PCP) and maximum pressure rise rate (MPRR) under the imposed limits. Overall, the peak load using the new injection strategy was shown to reach 22 bar brake mean effective pressure (BMEP) with a peak brake thermal efficiency (BTE) of 47.6%.« less

The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity.

PubMed

Leyton, M; Stewart, J

1992-10-23

Systemic injections of the kappa (kappa) opioid receptor agonist U-50,488H decreased male sexual behavior, locomotor activity, body temperature and bodily grooming, and induced body flattening. The U-50,488H-induced inhibitions of male sexual behavior were prevented by systemic injections of naloxone and by intra-cranial injections of the kappa opioid antagonist nor-binaltorphimine (NBNI). Injections of NBNI to either the ventral tegmental area (VTA) or the nucleus accumbens septi (NAS) increased female-directed behavior, and prevented the U-50,488H-induced decreases in female-directed behavior. Intra-VTA NBNI prevented U-50,488H-induced decreases in the mean number of ejaculations, intra-NAS NBNI prevented U-50,488H-induced increases in copulation latencies. Intra-medial preoptic area (mPOA) injections of NBNI increased female-directed behavior, and attenuated U-50,488H-induced decreases in female-directed behavior as well as U-50,488H-induced increases in both copulation and ejaculation latencies. Injections of NBNI dorsal to the mPOA were ineffective. Two of 26 days following the central injection of NBNI, systemic injections of U-50,488H remained behaviorally ineffective, leaving both sexual behavior and locomotor activity undiminished. These results suggest that the stimulation of central kappa opioid receptors inhibits sexual behavior in the male rat; perhaps endogenous kappa opioid agonists induce sexual refractory periods.

78 FR 32081 - Airworthiness Directives; Aircraft Industries a.s. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... Injection System WATER INJECTION circuit ON breakter. TCL TQ=min. 60% WATER INJECTION/ON push- Push and hold till amber button. WATER INJECTION signal comes on (on the front control panel) Before throttling back power: WATER INJECTION/OFF push- Push and check amber button. WATER INJECTION signal extinguishes...

Application of direct-injection detector integrated with the multi-pumping flow system to chemiluminescence determination of the total polyphenol index.

PubMed

Nalewajko-Sieliwoniuk, Edyta; Iwanowicz, Magdalena; Kalinowski, Sławomir; Kojło, Anatol

2016-03-10

In this work, we present a novel chemiluminescence (CL) method based on direct-injection detector (DID) integrated with the multi-pumping flow system (MPFS) to chemiluminescence determination of the total polyphenol index. In this flow system, the sample and the reagents are injected directly into the cone-shaped detection cell placed in front of the photomultiplier window. Such construction of the detection chamber allows for fast measurement of the CL signal in stopped-flow conditions immediately after mixing the reagents. The proposed DID-CL-MPFS method is based on the chemiluminescence of nanocolloidal manganese(IV)-hexametaphosphate-ethanol system. The application of ethanol as a sensitizer, eliminated the use of carcinogenic formaldehyde. Under the optimized experimental conditions, the chemiluminescence intensities are proportional to the concentration of gallic acid in the range from 5 to 350 ng mL(-1). The DID-CL-MPFS method offers a number of advantages, including low limit of detection (0.80 ng mL(-1)), high precision (RSD = 3.3%) and high sample throughput (144 samples h(-1)) as well as low consumption of reagents, energy and low waste generation. The proposed method has been successfully applied to determine the total polyphenol index (expressed as gallic acid equivalent) in a variety of plant-derived food samples (wine, tea, coffee, fruit and vegetable juices, herbs, spices). Copyright © 2016 Elsevier B.V. All rights reserved.

Effect of the Ethanol Injection Moment During Compression Stroke on the Combustion of Ethanol - Diesel Dual Direct Injection Engine

NASA Astrophysics Data System (ADS)

Liang, Yu; Zhou, Liying; Huang, Haomin; Xu, Mingfei; Guo, Mei; Chen, Xin

2018-01-01

A set of GDI system is installed on a F188 single-cylinder, air-cooled and direct injection diesel engine, which is used for ethanol injection, with the injection time controlled by the crank angle signal collected by AVL angle encoder. The injection of ethanol amounts to half of the thermal equivalent of an original diesel fuel. A 3D combustion model is established for the ethanol - diesel dual direct injection engine. Diesel was injected from the original fuel injection system, with a fuel supply advance angle of 20°CA. The ethanol was injected into the cylinder during compression process. Diesel injection began after the completion of ethanol injection. Ethanol injection starting point of 240°CA, 260°CA, 280°CA, 300°CA and 319.4°CA were simulated and analyzed. Due to the different timing of ethanol injection, the ignition of the ethanol mixture when diesel fires, results in non-uniform ignition distribution and flame propagation rate, since the distribution and concentration gradients of the ethanol mixture in the cylinder are different, thus affecting the combustion process. The results show that, when ethanol is injected at 319.4°CA, the combustion heat release rate and the pressure rise rate during the initial stage are the highest. Also, the maximum combustion pressure, with a relatively advance phase, is the highest. In case of later initial ethanol injection, the average temperature in the cylinder during the initial combustion period will have a faster rise. In case of initial injection at 319.4°CA, the average temperature in the cylinder is the highest, followed by 240°CA ethanol injection. In the post-combustion stage, the earlier ethanol injection will result in higher average temperature in the cylinder and more complete fuel combustion. The injection of ethanol at 319.4°CA produces earlier and highest NOX emissions.

On the Experimental and Theoretical Investigations of Lean Partially Premixed Combustion, Burning Speed, Flame Instability and Plasma Formation of Alternative Fuels at High Temperatures and Pressures

NASA Astrophysics Data System (ADS)

Askari, Omid

This dissertation investigates the combustion and injection fundamental characteristics of different alternative fuels both experimentally and theoretically. The subjects such as lean partially premixed combustion of methane/hydrogen/air/diluent, methane high pressure direct-injection, thermal plasma formation, thermodynamic properties of hydrocarbon/air mixtures at high temperatures, laminar flames and flame morphology of synthetic gas (syngas) and Gas-to-Liquid (GTL) fuels were extensively studied in this work. These subjects will be summarized in three following paragraphs. The fundamentals of spray and partially premixed combustion characteristics of directly injected methane in a constant volume combustion chamber have been experimentally studied. The injected fuel jet generates turbulence in the vessel and forms a turbulent heterogeneous fuel-air mixture in the vessel, similar to that in a Compressed Natural Gas (CNG) Direct-Injection (DI) engines. The effect of different characteristics parameters such as spark delay time, stratification ratio, turbulence intensity, fuel injection pressure, chamber pressure, chamber temperature, Exhaust Gas recirculation (EGR) addition, hydrogen addition and equivalence ratio on flame propagation and emission concentrations were analyzed. As a part of this work and for the purpose of control and calibration of high pressure injector, spray development and characteristics including spray tip penetration, spray cone angle and overall equivalence ratio were evaluated under a wide range of fuel injection pressures of 30 to 90 atm and different chamber pressures of 1 to 5 atm. Thermodynamic properties of hydrocarbon/air plasma mixtures at ultra-high temperatures must be precisely calculated due to important influence on the flame kernel formation and propagation in combusting flows and spark discharge applications. A new algorithm based on the statistical thermodynamics was developed to calculate the ultra-high temperature plasma composition and thermodynamic properties. The method was applied to compute the thermodynamic properties of hydrogen/air and methane/air plasma mixtures for a wide range of temperatures (1,000-100,000 K), pressures (10-6-100 atm) and different equivalence ratios within flammability limit. In calculating the individual thermodynamic properties of the atomic species, the Debye-Huckel cutoff criterion has been used for terminating the series expression of the electronic partition function. A new differential-based multi-shell model was developed in conjunction with Schlieren photography to measure laminar burning speed and to study the flame instabilities for different alternative fuels such as syngas and GTL. Flame instabilities such as cracking and wrinkling were observed during flame propagation and discussed in terms of the hydrodynamic and thermo-diffusive effects. Laminar burning speeds were measured using pressure rise data during flame propagation and power law correlations were developed over a wide range of temperatures, pressures and equivalence ratios. As a part of this work, the effect of EGR addition and substitution of nitrogen with helium in air on flame morphology and laminar burning speed were extensively investigated. The effect of cell formation on flame surface area of syngas fuel in terms of a newly defined parameter called cellularity factor was also evaluated. In addition to that the experimental onset of auto-ignition and theoretical ignition delay times of premixed GTL/air mixture were determined at high pressures and low temperatures over a wide range of equivalence ratios.

[Detection of rifampicin concentration in cerebrospinal fluid by online enrichment and restricted-access media coupled with high-performance liquid chromatography].

PubMed

Yang, Xiaoping; Zhang, Xiaohui; Huang, Yanping; Wang, Rong; Xia, Hua; Li, Wenbin; Guo, YouMin

2015-11-01

To establish a method for detecting rifampicin in human cerebrospinal fluid (CSF) with restricted access media coupled with high-performance liquid chromatography that allows online direct sample injection and enrichment. We used the column of restricted access media as the pre-treatment column and a C18 column as the analytical column. The mobile phase of pre-treatment column was water-methanol (95:5,V/V) and the flow rate was 1 mL/min; the mobile phase of the analytical column was methanol-acetonitrile-10 mmol/L ammonuium acetate (volume ratio of 60:5:35). The detection wavelength was 254 nm and the column temperature was set at 25 degrees celsius;. For an injection volume of 100 µL, the peak area of rifampicin was 5.33 times that for an injection volume of 20 µL, and the limit of detection was effectively improved. The calibration curve showed an excellent linear relationship (r=0.9997) between rifampicin concentrations and peak areas within the concentration range of 0.25 to 8 µg/mL in CSF. The limits of detection and quantification was 0.07 µg/mL and 0.25 µg/mL, respecetively, with intra-day and inter-day assay precisions and relative standard deviation (RSD%) all below 5%. The recoveries of rifampicin at 3 blank spiked levels (low, medium, and high) ranged from 87.69% to 102.11%. In patients taking oral rifampicin at the dose of 10 mg/kg, the average rifampicin concentration was 0.29 in the CSF at 2 h after medication. The method we established is simple and fast for detecting rifampicin in CSF and allows direct online injection and enrichment with good detection precisions and accuracies.

Critical Science Issues for Direct Drive Inertial Fusion Energy

NASA Astrophysics Data System (ADS)

Dahlburg, Jill P.; Gardner, John H.; Schmitt, Andrew J.; Obenschain, S. P.

1998-09-01

There are several topics that require resolution prior to the construction of an Inertial Fusion Energy [IFE] laboratory Engineering Test Facility [ETF]: a pellet that produces high gain; a pellet fabrication system that cost-effectively and rapidly manufactures these pellets; a sufficiently uniform and durable high repetition-rate laser pellet driver; a practical target injection system that provides accurate pellet aiming; and, a target chamber that will survive the debris and radiation of repeated high-gain pellet implosions. In this summary we describe the science issues and opportunities that are involved in the design of a successful high gain direct drive Inertial Confinement Fusion [ICF] pellet.

Seismic and aseismic fault slip in response to fluid injection observed during field experiments at meter scale

NASA Astrophysics Data System (ADS)

Cappa, F.; Guglielmi, Y.; De Barros, L.; Wynants-Morel, N.; Duboeuf, L.

2017-12-01

During fluid injection, the observations of an enlarging cloud of seismicity are generally explained by a direct response to the pore pressure diffusion in a permeable fractured rock. However, fluid injection can also induce large aseismic deformations which provide an alternative mechanism for triggering and driving seismicity. Despite the importance of these two mechanisms during fluid injection, there are few studies on the effects of fluid pressure on the partitioning between seismic and aseismic motions under controlled field experiments. Here, we describe in-situ meter-scale experiments measuring synchronously the fluid pressure, the fault motions and the seismicity directly in a fault zone stimulated by controlled fluid injection at 280 m depth in carbonate rocks. The experiments were conducted in a gallery of an underground laboratory in south of France (LSBB, http://lsbb.eu). Thanks to the proximal monitoring at high-frequency, our data show that the fluid overpressure mainly induces a dilatant aseismic slip (several tens of microns up to a millimeter) at the injection. A sparse seismicity (-4 < Mw < -3) is observed several meters away from the injection, in a part of the fault zone where the fluid overpressure is null or very low. Using hydromechanical modeling with friction laws, we simulated an experiment and investigated the relative contribution of the fluid pressure diffusion and stress transfer on the seismic and aseismic fault behavior. The model reproduces the hydromechanical data measured at injection, and show that the aseismic slip induced by fluid injection propagates outside the pressurized zone where accumulated shear stress develops, and potentially triggers seismicity. Our models also show that the permeability enhancement and friction evolution are essential to explain the fault slip behavior. Our experimental results are consistent with large-scale observations of fault motions at geothermal sites (Wei et al., 2015; Cornet, 2016), and suggest that controlled field experiments at meter-scale are important for better assessing the role of fluid pressure in natural and human-induced earthquakes.

Thermal analysis in the rat glioma model during directly multipoint injection hyperthermia incorporating magnetic nanoparticles.

PubMed

Liu, Lianke; Ni, Fang; Zhang, Jianchao; Wang, Chunyu; Lu, Xiang; Guo, Zhirui; Yao, Shaowei; Shu, Yongqian; Xu, Ruizhi

2011-12-01

Hyperthermia incorporating magnetic nanoparticles (MNPs) is a hopeful therapy to cancers and steps into clinical tests at present. However, the clinical plan of MNPs deposition in tumors, especially applied for directly multipoint injection hyperthermia (DMIH), and the information of temperature rise in tumors by DMIH is lack of studied. In this paper, we mainly discussed thermal distributions induced by MNPs in the rat brain tumors during DMIH. Due to limited experimental measurement for detecting thermal dose of tumors, and in order to acquire optimized results of temperature distributions clinically needed, we designed the thermal model in which three types of MNPs injection for hyperthermia treatments were simulated. The simulated results showed that MNPs injection plan played an important role in determining thermal distribution, as well as the overall dose of MNPs injected. We found that as injected points enhanced, the difference of temperature in the whole tumor volume decreased. Moreover, from temperature detecting data by Fiber Optic Temperature Sensors (FOTSs) in glioma bearing rats during MNPs hyperthermia, we found the temperature errors by FOTSs reduced as the number of points injected enhanced. Finally, the results showed that the simulations are preferable and the optimized plans of the numbers and spatial positions of MNPs points injected are essential during direct injection hyperthermia.

Dark Current Characterization of SW HgCdTe IRFPAs Detectors on Si Substrate with Long Time Integration

NASA Astrophysics Data System (ADS)

Song, P. Y.; Ye, Z. H.; Huang, A. B.; Chen, H. L.; Hu, X. N.; Ding, R. J.; He, L.

2016-09-01

The dark currents of two short wave (SW) HgCdTe infrared focal plane arrays (IRFPA) detectors hybridized with direct injection (DI) readout and capacitance transimpedance amplifier (CTIA) with long time integration were investigated. The cutoff wavelength of the two SW IRFPAs is about 2.6 μm at 84 K. The dark current densities of DI and CTIA samples are approximately 8.0 × 10-12 A/cm2 and 7.2 × 10-10 A/cm2 at 110 K, respectively. The large divergence of the dark current density might arise from the injection efficiency difference of the two readouts. The low injection efficiency of the DI readout, compared with the high injection efficiency of the CTIA readout at low temperature, makes the dark current density of the DI sample much lower than that of the CTIA sample. The experimental value of injection efficiency of the DI sample was evaluated as 1.1% which is consistent with its theoretical value.

Chemical tailoring of steam to remediate underground mixed waste contaminents

DOEpatents

Aines, Roger D.; Udell, Kent S.; Bruton, Carol J.; Carrigan, Charles R.

1999-01-01

A method to simultaneously remediate mixed-waste underground contamination, such as organic liquids, metals, and radionuclides involves chemical tailoring of steam for underground injection. Gases or chemicals are injected into a high pressure steam flow being injected via one or more injection wells to contaminated soil located beyond a depth where excavation is possible. The injection of the steam with gases or chemicals mobilizes contaminants, such as metals and organics, as the steam pushes the waste through the ground toward an extraction well having subatmospheric pressure (vacuum). The steam and mobilized contaminants are drawn in a substantially horizontal direction to the extraction well and withdrawn to a treatment point above ground. The heat and boiling action of the front of the steam flow enhance the mobilizing effects of the chemical or gas additives. The method may also be utilized for immobilization of metals by using an additive in the steam which causes precipitation of the metals into clusters large enough to limit their future migration, while removing any organic contaminants.

Theoretical investigation of injection-locked high modulation bandwidth quantum cascade lasers.

PubMed

Meng, Bo; Wang, Qi Jie

2012-01-16

In this study, we report for the first time to our knowledge theoretical investigation of modulation responses of injection-locked mid-infrared quantum cascade lasers (QCLs) at wavelengths of 4.6 μm and 9 μm, respectively. It is shown through a three-level rate equations model that the direct intensity modulation of QCLs gives the maximum modulation bandwidths of ~7 GHz at 4.6 μm and ~20 GHz at 9 μm. By applying the injection locking scheme, we find that the modulation bandwidths of up to ~30 GHz and ~70 GHz can be achieved for QCLs at 4.6 μm and 9 μm, respectively, with an injection ratio of 5 dB. The result also shows that an ultrawide modulation bandwidth of more than 200 GHz is possible with a 10 dB injection ratio for QCLs at 9 μm. An important characteristic of injection-locked QCLs is the nonexistence of unstable locking region in the locking map, in contrast to their diode laser counterparts. We attribute this to the ultra-short upper laser state lifetimes of QCLs.

Geohydrologic reconnaissance of drainage wells in Florida; an interim report

USGS Publications Warehouse

Kimrey, Joel O.; Fayard, Larry D.

1982-01-01

Drainage wells are used to inject surface waters directly into an aquifer, or shallow ground waters directly into a deeper aquifer, primarily by gravity. Such wells in Florida may be grouped into two broad types: (1) Surface-water injection wells, and (2) interaquifer connector wells. Surface-water injection wells are commonly used to supplement drainage for urban areas in karst terranes of central and north Florida. Data are available for 25 wells in the Ocala, Live Oak, and Orlando areas that allow comparison of the quality of water samples from these Floridan aquifer drainage wells with allowable contaminant levels. Comparison indicates that maximum contaminant levels for turbidity, color, and iron, manganese, and lead concentrations are equaled or exceeded in some drainage-well samples, and relatively high counts for coliform bacteria are present in most wells. Interaquifer connector wells are used in the phosphate mining areas of Polk and Hillsborough Counties, to drain mining operations and recharge the Floridan aquifer. Water-quality data available from 13 connector wells indicate that samples from most of these wells exceed standards values for iron concentration and turbidity. One well yielded a highly mineralized water, and samples from 6 of the other 12 wells exceed standards values for gross alpha concentrations. (USGS)

Hydrodynamic injection with pneumatic valving for microchip electrophoresis with total analyte utilization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Xuefei; Kelly, Ryan T.; Danielson, William F.

2011-04-26

A novel hydrodynamic injector that is directly controlled by a pneumatic valve has been developed for reproducible microchip capillary electrophoresis (CE) separations. The poly(dimethylsiloxane) (PDMS) devices used for evaluation comprise a separation channel, a side channel for sample introduction, and a pneumatic valve aligned at the intersection of the channels. A low pressure (≤ 3 psi) applied to the sample reservoir is sufficient to drive sample into the separation channel. The rapidly actuated pneumatic valve enables injection of discrete sample plugs as small as ~100 pL for CE separation. The injection volume can be easily controlled by adjusting the intersectionmore » geometry, the solution back pressure and the valve actuation time. Sample injection could be reliably operated at different frequencies (< 0.1 Hz to >2 Hz) with good reproducibility (peak height relative standard deviation ≤ 3.6%) and no sampling biases associated with the conventional electrokinetic injections. The separation channel was dynamically coated with a cationic polymer, and FITC-labeled amino acids were employed to evaluate the CE separation. Highly efficient (≥ 7.0 × 103 theoretical plates for the ~2.4 cm long channel) and reproducible CE separations were obtained. The demonstrated method has numerous advantages compared with the conventional techniques, including repeatable and unbiased injections, no sample waste, high duty cycle, controllable injected sample volume, and fewer electrodes with no need for voltage switching. The prospects of implementing this injection method for coupling multidimensional separations, for multiplexing CE separations and for sample-limited bioanalyses are discussed.« less

An Assessment of Combustion Dynamics in a Low-Nox, Second-Generation Swirl-Venturi Lean Direct Injection Combustion Concept

NASA Technical Reports Server (NTRS)

Tacina, K. M.; Chang, C. T.; Lee, P.; Mongia, H.; Podboy, D. P.; Dam, B.

2015-01-01

Dynamic pressure measurements were taken during flame-tube emissions testing of three second-generation swirl-venturi lean direct injection (SV-LDI) combustor configurations. These measurements show that combustion dynamics were typically small. However, a small number of points showed high combustion dynamics, with peak-to-peak dynamic pressure fluctuations above 0.5 psi. High combustion dynamics occurred at low inlet temperatures in all three SV-LDI configurations, so combustion dynamics were explored further at low temperature conditions. A point with greater than 1.5 psi peak-to-peak dynamic pressure fluctuations was identified at an inlet temperature of 450!F, a pressure of 100 psia, an air pressure drop of 3%, and an overall equivalence ratio of 0.35. This is an off design condition: the temperature and pressure are typical of 7% power conditions, but the equivalence ratio is high. At this condition, the combustion dynamics depended strongly on the fuel staging. Combustion dynamics could be reduced significantly without changing the overall equivalence ratio by shifting the fuel distribution between stages. Shifting the fuel distribution also decreased NOx emissions.

University of Idaho's low-speed flex fuel direct-injected 797cc two-stroke rear drive snowmobile.

DOT National Transportation Integrated Search

2012-06-01

The University of Idahos entry into the 2012 SAE Clean Snowmobile Challenge uses a Ski-Doo XP chassis with a low-speed 797 cc direct-injection two-stroke powered snowmobile modified for flex fuel use on blended ethanol fuel. A battery-less direct ...

Coherent radio-frequency detection for narrowband direct comb spectroscopy.

PubMed

Anstie, James D; Perrella, Christopher; Light, Philip S; Luiten, Andre N

2016-02-22

We demonstrate a scheme for coherent narrowband direct optical frequency comb spectroscopy. An extended cavity diode laser is injection locked to a single mode of an optical frequency comb, frequency shifted, and used as a local oscillator to optically down-mix the interrogating comb on a fast photodetector. The high spectral coherence of the injection lock generates a microwave frequency comb at the output of the photodiode with very narrow features, enabling spectral information to be further down-mixed to RF frequencies, allowing optical transmittance and phase to be obtained using electronics commonly found in the lab. We demonstrate two methods for achieving this step: a serial mode-by-mode approach and a parallel dual-comb approach, with the Cs D1 transition at 894 nm as a test case.

Staged direct injection diesel engine

DOEpatents

Baker, Quentin A.

1985-01-01

A diesel engine having staged injection for using lower cetane number fuels than No. 2 diesel fuel. The engine includes a main fuel injector and a pilot fuel injector. Pilot and main fuel may be the same fuel. The pilot injector injects from five to fifteen percent of the total fuel at timings from 20.degree. to 180.degree. BTDC depending upon the quantity of pilot fuel injected, the fuel cetane number and speed and load. The pilot fuel injector is directed toward the centerline of the diesel cylinder and at an angle toward the top of the piston, avoiding the walls of the cylinder. Stratification of the early injected pilot fuel is needed to reduce the fuel-air mixing rate, prevent loss of pilot fuel to quench zones, and keep the fuel-air mixture from becoming too fuel lean to become effective. In one embodiment, the pilot fuel injector includes a single hole for injection of the fuel and is directed at approximately 48.degree. below the head of the cylinder.

Percutaneous Direct Needle Puncture and Transcatheter N-butyl Cyanoacrylate Injection Techniques for the Embolization of Pseudoaneurysms and Aneurysms of Arteries Supplying the Hepato-pancreato-biliary System and Gastrointestinal Tract

PubMed Central

Yadav, Rajanikant R; Boruah, Deb K; Bhattacharyya, Vishwaroop; Prasad, Raghunandan; Kumar, Sheo; Saraswat, V A; Kapoor, V K; Saxena, Rajan

2016-01-01

Aims: The aim of this study was to evaluate the safety and clinical efficacy of percutaneous direct needle puncture and transcatheter N-butyl cyanoacrylate (NBCA) injection techniques for the embolization of pseudoaneurysms and aneurysms of arteries supplying the hepato-pancreato-biliary (HPB) system and gastrointestinal (GI) tract. Subjects and Methods: A hospital-based cross-sectional retrospective study was conducted, where the study group comprised 11 patients with pseudoaneurysms/aneurysms of arteries supplying the HPB system and GI tract presenting to a tertiary care center from January 2015 to June 2016. Four patients (36.4%) underwent percutaneous direct needle puncture of pseudoaneurysms with NBCA injection, 3 patients (27.3%) underwent transcatheter embolization with NBCA as sole embolic agent, and in 4 patients (36.4%), transcatheter NBCA injection was done along with coil embolization. Results: This retrospective study comprised 11 patients (8 males and 3 females) with mean age of 35.8 years ± 1.6 (standard deviation [SD]). The mean volume of NBCA: ethiodized oil (lipiodol) mixture injected by percutaneous direct needle puncture was 0.62 ml ± 0.25 (SD) (range = 0.5–1 ml), and by transcatheter injection, it was 0.62 ml ± 0.37 (SD) (range = 0.3–1.4 ml). Embolization with NBCA was technically and clinically successful in all patients (100%). No recurrence of bleeding or recurrence of pseudoaneurysm/aneurysm was noted in our study. Conclusions: Percutaneous direct needle puncture of visceral artery pseudoaneurysms and NBCA glue injection and transcatheter NBCA injection for embolization of visceral artery pseudoaneurysms and aneurysms are cost-effective techniques that can be used when coil embolization is not feasible or has failed. PMID:28123838

Accuracy of palpation-directed intra-articular glenohumeral injection confirmed by magnetic resonance arthrography.

PubMed

Powell, Scott E; Davis, Shane M; Lee, Emily H; Lee, Robert K; Sung, Ryan M; McGroder, Claire; Kouk, Shalen; Lee, Christopher S

2015-02-01

The aim of this study was to determine the accuracy of anatomic palpation-directed injections in the office setting. Two hundred twenty-six shoulders in 208 patients were studied using a 0.2-Tesla extremity scanner after the injection of gadolinium-diethylene triamine pentaacetic acid-saline. All patients were injected in a sterile fashion by a single board-certified shoulder surgeon using an anterior approach by palpating the rotator interval anterior to the acromioclavicular joint and angling the needle 45° lateral and 45° caudad. All injections, successful or otherwise, were single injections. Magnetic resonance (MR) arthrograms were retrospectively read by 2 musculoskeletal fellowship-trained, board certified radiologists to determine whether the injection was in the glenohumeral joint. Two hundred one of the 226 injections were successful (88.9%). Of the 25 unsuccessful injections, the contrast material extravasated out of the capsule in 5 cases and into the subscapularis tendon in 10 cases. The contrast material was injected into the subacromial space in 9 cases, into the rotator interval fat in 9 cases, and into extracapsular tissue in 6 cases. There was insufficient volume of contrast material in 10 cases. The accuracy rate was 88.9%. There were no complications. The palpation-directed rotator interval anterior approach technique for intra-articular glenohumeral MR arthrogram injections performed by a single surgeon was 88.9% accurate. Level IV, therapeutic case series. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

High-speed fuel tracer fluorescence and OH radical chemiluminescence imaging in a spark-ignition direct-injection engine

NASA Astrophysics Data System (ADS)

Smith, James D.; Sick, Volker

2005-11-01

An innovative technique has been demonstrated to achieve crank-angle-resolved planar laser-induced fluorescence (PLIF) of fuel followed by OH* chemiluminescence imaging in a firing direct-injected spark-ignition engine. This study used two standard KrF excimer lasers to excite toluene for tracking fuel distribution. The intensified camera system was operated at single crank-angle resolution at 2000 revolutions per minute (RPM) for 500 consecutive cycles. Through this work, it has been demonstrated that toluene and OH* can be imaged through the same optical setup while similar signal levels are obtained from both species, even at these high rates. The technique is useful for studying correlations between fuel distribution and subsequent ignition and flame propagation without the limitations of phase-averaging imaging approaches. This technique is illustrated for the effect of exhaust gas recirculation on combustion and will be useful for studies of misfire causes. Finally, a few general observations are presented as to the effect of preignition fuel distribution on subsequent combustion.

High-speed fuel tracer fluorescence and OH radical chemiluminescence imaging in a spark-ignition direct-injection engine.

PubMed

Smith, James D; Sick, Volker

2005-11-01

An innovative technique has been demonstrated to achieve crank-angle-resolved planar laser-induced fluorescence (PLIF) of fuel followed by OH* chemiluminescence imaging in a firing direct-injected spark-ignition engine. This study used two standard KrF excimer lasers to excite toluene for tracking fuel distribution. The intensified camera system was operated at single crank-angle resolution at 2000 revolutions per minute (RPM) for 500 consecutive cycles. Through this work, it has been demonstrated that toluene and OH* can be imaged through the same optical setup while similar signal levels are obtained from both species, even at these high rates. The technique is useful for studying correlations between fuel distribution and subsequent ignition and flame propagation without the limitations of phase-averaging imaging approaches. This technique is illustrated for the effect of exhaust gas recirculation on combustion and will be useful for studies of misfire causes. Finally, a few general observations are presented as to the effect of preignition fuel distribution on subsequent combustion.

Using the direct-injection model of early uveal melanoma hepatic metastasis to identify TPS as a potentially useful serum biomarker.

PubMed

Barak, Vivian; Frenkel, Shahar; Valyi-Nagy, Klara; Leach, Lu; Apushkin, Marsha A; Lin, Amy Y; Kalickman, Inna; Baumann, Nikola A; Pe'er, Jacob; Maniotis, Andrew J; Folberg, Robert

2007-10-01

To develop a method to screen for serum biomarkers of early hepatic metastasis from uveal melanoma. Cytokeratin 18 (TPS) was identified from gene expression profiles as protein generated by highly invasive uveal melanoma cells. Sera were collected from two groups of 15 SCID mice 2 weeks after injection of either tissue culture medium or MUM2B human metastatic uveal melanoma cells into the mouse liver. Serum TPS levels were assayed in 53 healthy human controls, 64 uveal melanoma patients who were disease free for at least 10 years, and 37 patients with metastatic uveal melanoma. After 2 weeks, small hepatic nodules (0.1-2.8 mm; mean, 0.80 mm) developed in 11 of 15 mice injected with MUM2B cells. Serum TPS levels in media-injected mice (84.7 U/L) were substantially lower than levels in MUM2B-injected mice (601 mug/L). TPS levels were significantly higher (P < 0.0001) in patients with metastatic uveal melanoma (139.63 +/- 22.20) than in healthy controls (54.23 +/- 0.01) or in patients free of disease (69.29 +/- 9.76). Significant differences were found between TPS levels before and after the development of hepatic metastases (P < 0.01), and serum TPS levels became elevated in four patients at least 6 months before the detection of hepatic metastases by abdominal ultrasonography. The direct-injection model of uveal melanoma in the mouse liver may be used to screen for potential serum biomarkers of metastatic uveal melanoma.

Underground Injection Control, Hydraulic Fracturing, and Sources of Drinking Water in the Western United States

NASA Astrophysics Data System (ADS)

Jackson, R. B.; Kang, M.

2016-12-01

Oil and gas extraction is expanding in the United States, attributable to the success of high-volume hydraulic fracturing, and associated wastewater disposal is increasing as a result. The United States currently has approximately 180,000 Class II injection wells associated with the oil and gas industry, more than 50,000 of them in California. Hydraulic fracturing and underground injection often occur many thousands of feet belowground. Previously, however, we documented shallow hydraulic fracturing and other oil and gas activities across the western United States in particular, including California and Wyoming. In eight CA counties, for example, as many as 19% and 35% of oil/gas activities have occurred directly in freshwater zones and USDWs, respectively (Kang and Jackson 2016 PNAS). Here we expand this analysis to examine the underground injection control program and accompanying hydrogeologic variables found in California and elsewhere.

INDUCED SEISMICITY. Seismicity triggered by fluid injection-induced aseismic slip.

PubMed

Guglielmi, Yves; Cappa, Frédéric; Avouac, Jean-Philippe; Henry, Pierre; Elsworth, Derek

2015-06-12

Anthropogenic fluid injections are known to induce earthquakes. The mechanisms involved are poorly understood, and our ability to assess the seismic hazard associated with geothermal energy or unconventional hydrocarbon production remains limited. We directly measure fault slip and seismicity induced by fluid injection into a natural fault. We observe highly dilatant and slow [~4 micrometers per second (μm/s)] aseismic slip associated with a 20-fold increase of permeability, which transitions to faster slip (~10 μm/s) associated with reduced dilatancy and micro-earthquakes. Most aseismic slip occurs within the fluid-pressurized zone and obeys a rate-strengthening friction law μ = 0.67 + 0.045ln(v/v₀) with v₀ = 0.1 μm/s. Fluid injection primarily triggers aseismic slip in this experiment, with micro-earthquakes being an indirect effect mediated by aseismic creep. Copyright © 2015, American Association for the Advancement of Science.

Bio-inspired piezoelectric artificial hair cell sensor fabricated by powder injection molding

NASA Astrophysics Data System (ADS)

Han, Jun Sae; Oh, Keun Ha; Moon, Won Kyu; Kim, Kyungseop; Joh, Cheeyoung; Seo, Hee Seon; Bollina, Ravi; Park, Seong Jin

2015-12-01

A piezoelectric artificial hair cell sensor was fabricated by the powder injection molding process in order to make an acoustic vector hydrophone. The entire process of powder injection molding was developed and optimized for PMN-PZT ceramic powder. The artificial hair cell sensor, which consists of high aspect ratio hair cell and three rectangular mechanoreceptors, was precisely fabricated through the developed powder injection molding process. The density and the dielectric property of the fabricated sensor shows 98% of the theoretical density and 85% of reference dielectric property of PMN-PZT ceramic powder. With regard to homogeneity, three rectangular mechanoreceptors have the same dimensions, with 3 μm of tolerance with 8% of deviation of dielectric property. Packaged vector hydrophones measure the underwater acoustic signals from 500 to 800 Hz with -212 dB of sensitivity. Directivity of vector hydrophone was acquired at 600 Hz as analyzing phase differences of electric signals.

Thermally Stratified Compression Ignition: A new advanced low temperature combustion mode with load flexibility

DOE PAGES

Lawler, Benjamin; Splitter, Derek; Szybist, James; ...

2017-03-01

We introduce a new advanced combustion mode, called Thermally Stratified Compression Ignition (TSCI), which uses direct water injection to control both the average temperature and the temperature distribution prior to ignition, thereby providing cycle-to-cycle control over the start and rate of heat release in Low Temperature Combustion (LTC). Experiments were conducted to fundamentally understand the effects of water injection on heat release in LTC. Our results show that water injection retards the start of combustion due to the latent heat of vaporization of the injected water. Furthermore, for start of water injection timings between 20 and 70 degrees before topmore » dead center, combustion is significantly elongated compared to without water injection. The 10–90% burn duration with 6.6 and 9.0 mg of water per cycle was 77% and 146% longer than without water injection, respectively. Forced thermal stratification result from a direct water injection which reduces the heat release rate by local evaporative cooling. Finally, the load limits with and without water injection were determined experimentally. Without water injection, the load range was 2.3–3.6 bar gross IMEP. By using water injection to control heat release, the load range in TSCI was 2.3–8.4 bar gross IMEP, which is a range expansion of over 350%. These results demonstrate that direct water injection can provide significant improvements to both controllability and the range of operability of LTC, thereby resolving the major challenges associated with HCCI.« less

Thermally Stratified Compression Ignition: A new advanced low temperature combustion mode with load flexibility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawler, Benjamin; Splitter, Derek; Szybist, James

We introduce a new advanced combustion mode, called Thermally Stratified Compression Ignition (TSCI), which uses direct water injection to control both the average temperature and the temperature distribution prior to ignition, thereby providing cycle-to-cycle control over the start and rate of heat release in Low Temperature Combustion (LTC). Experiments were conducted to fundamentally understand the effects of water injection on heat release in LTC. Our results show that water injection retards the start of combustion due to the latent heat of vaporization of the injected water. Furthermore, for start of water injection timings between 20 and 70 degrees before topmore » dead center, combustion is significantly elongated compared to without water injection. The 10–90% burn duration with 6.6 and 9.0 mg of water per cycle was 77% and 146% longer than without water injection, respectively. Forced thermal stratification result from a direct water injection which reduces the heat release rate by local evaporative cooling. Finally, the load limits with and without water injection were determined experimentally. Without water injection, the load range was 2.3–3.6 bar gross IMEP. By using water injection to control heat release, the load range in TSCI was 2.3–8.4 bar gross IMEP, which is a range expansion of over 350%. These results demonstrate that direct water injection can provide significant improvements to both controllability and the range of operability of LTC, thereby resolving the major challenges associated with HCCI.« less

Studies on the injection molding of polyvinyl chloride: Analysis of viscous heating and degradation in simple geometries

NASA Astrophysics Data System (ADS)

Garcia, Jose Luis

2000-10-01

In injection molding processes, computer aided engineering (CAE) allows processors to evaluate different process parameters in order to achieve complete filling of a cavity and, in some cases, it predicts shrinkage and warpage. However, because commercial computational packages are used to design complex geometries, detail in the thickness direction is limited. Approximations in the thickness direction lead to the solution of a 2½-D problem instead of a 3-D problem. These simplifications drastically reduce computational times and memory requirements. However, these approximations hinder the ability to predict thermal and/or mechanical degradation. The goal of this study was to determine the degree of degradation during PVC injection molding and to compare the results with a computational model. Instead of analyzing degradation in complex geometries, the computational analysis and injection molding trials were performed on typical sections found in complex geometries, such as flow in a tube, flow in a rectangular channel, and radial flow. This simplification reduces the flow problem to a 1-D problem and allows one to develop a computational model with a higher level of detail in the thickness direction, essential for the determination of degradation. Two different geometries were examined in this study: a spiral mold, in order to approximate the rectangular channel, and a center gated plate for the radial flow. Injection speed, melt temperature, and shot size were varied. Parts varying in degree of degradation, from no to severe degradation, were produced to determine possible transition points. Furthermore, two different PVC materials were used, low and high viscosity, M3800 and M4200, respectively (The Geon Company, Avon Lake, OH), to correlate the degree of degradation with the viscous heating observed during injection. It was found that a good agreement between experimental and computational results was obtained only if the reaction was assumed to be more thermally sensitive than found in literature. The results from this study show that, during injection, the activation energy for degradation was 65 kcal/mol, compared to 17--30 kcal/mol found in literature for quiescent systems.

A multi-directional tracer test in the fractured Chalk aquifer of E. Yorkshire, UK.

PubMed

Hartmann, S; Odling, N E; West, L J

2007-12-07

A multi-borehole radial tracer test has been conducted in the confined Chalk aquifer of E. Yorkshire, UK. Three different tracer dyes were injected into three injection boreholes and a central borehole, 25 m from the injection boreholes, was pumped at 330 m(3)/d for 8 days. The breakthrough curves show that initial breakthrough and peak times were fairly similar for all dyes but that recoveries varied markedly from 9 to 57%. The breakthrough curves show a steep rise to a peak and long tail, typical of dual porosity aquifers. The breakthrough curves were simulated using a 1D dual porosity model. Model input parameters were constrained to acceptable ranges determined from estimations of matrix porosity and diffusion coefficient, fracture spacing, initial breakthrough times and bulk transmissivity of the aquifer. The model gave equivalent hydraulic apertures for fractures in the range 363-384 microm, dispersivities of 1 to 5 m and matrix block sizes of 6 to 9 cm. Modelling suggests that matrix block size is the primary controlling parameter for solute transport in the aquifer, particularly for recovery. The observed breakthrough curves suggest results from single injection-borehole tracer tests in the Chalk may give initial breakthrough and peak times reasonably representative of the aquifer but that recovery is highly variable and sensitive to injection and abstraction borehole location. Consideration of aquifer heterogeneity suggests that high recoveries may be indicative of a high flow pathway adjacent, but not necessarily connected, to the injection and abstraction boreholes whereas low recoveries may indicate more distributed flow through many fractures of similar aperture.

Pre-injection brine production for managing pressure in compartmentalized CO₂ storage reservoirs

DOE PAGES

Buscheck, Thomas A.; White, Joshua A.; Chen, Mingjie; ...

2014-12-31

We present a reservoir management approach for geologic CO₂ storage that combines CO₂ injection with brine extraction. In our approach, dual-mode wells are initially used to extract formation brine and subsequently used to inject CO₂. These wells can also be used to monitor the subsurface during pre-injection brine extraction so that key data is acquired and analyzed prior to CO₂ injection. The relationship between pressure drawdown during pre-injection brine extraction and pressure buildup during CO₂ injection directly informs reservoir managers about CO₂ storage capacity. These data facilitate proactive reservoir management, and thus reduce costs and risks. The brine may bemore » used directly as make-up brine for nearby reservoir operations; it can also be desalinated and/or treated for a variety of beneficial uses.« less

Real-time ultrasound image classification for spine anesthesia using local directional Hadamard features.

PubMed

Pesteie, Mehran; Abolmaesumi, Purang; Ashab, Hussam Al-Deen; Lessoway, Victoria A; Massey, Simon; Gunka, Vit; Rohling, Robert N

2015-06-01

Injection therapy is a commonly used solution for back pain management. This procedure typically involves percutaneous insertion of a needle between or around the vertebrae, to deliver anesthetics near nerve bundles. Most frequently, spinal injections are performed either blindly using palpation or under the guidance of fluoroscopy or computed tomography. Recently, due to the drawbacks of the ionizing radiation of such imaging modalities, there has been a growing interest in using ultrasound imaging as an alternative. However, the complex spinal anatomy with different wave-like structures, affected by speckle noise, makes the accurate identification of the appropriate injection plane difficult. The aim of this study was to propose an automated system that can identify the optimal plane for epidural steroid injections and facet joint injections. A multi-scale and multi-directional feature extraction system to provide automated identification of the appropriate plane is proposed. Local Hadamard coefficients are obtained using the sequency-ordered Hadamard transform at multiple scales. Directional features are extracted from local coefficients which correspond to different regions in the ultrasound images. An artificial neural network is trained based on the local directional Hadamard features for classification. The proposed method yields distinctive features for classification which successfully classified 1032 images out of 1090 for epidural steroid injection and 990 images out of 1052 for facet joint injection. In order to validate the proposed method, a leave-one-out cross-validation was performed. The average classification accuracy for leave-one-out validation was 94 % for epidural and 90 % for facet joint targets. Also, the feature extraction time for the proposed method was 20 ms for a native 2D ultrasound image. A real-time machine learning system based on the local directional Hadamard features extracted by the sequency-ordered Hadamard transform for detecting the laminae and facet joints in ultrasound images has been proposed. The system has the potential to assist the anesthesiologists in quickly finding the target plane for epidural steroid injections and facet joint injections.

High frequency direct drive generation using white noise sources

NASA Astrophysics Data System (ADS)

Frazier, S.; Sebacher, K.; Lawry, D.; Prather, W.; Hoffer, G.

1994-12-01

Damped sinusoid direct drive injection on interconnecting cable bundles between subsystems has long been used as a technique for determining susceptibility to electromagnetic transients in military weapon systems. Questions arise, however, about the adequacy of this method of individually injected, single sinusoids in assuring subsystem strength against broad band threats. This issue has recently been raised in the latest revision of MIL-STD-461 that requires subsystems exhibit no malfunctions when subjected to a repetitive square wave pulse with fast rise and fall time (CS115). An extension to this approach would be to test subsystems using arbitrary waveforms. In recent years arbitrary waveform generators (AWG's) have been used to duplicate, with a high degree of fidelity, the waveforms measured on cable bundles in a system illuminated by fields in a system-level EMP simulator. However, the operating speeds of present AWG's do not allow the extension of this approach to meet new threats such as MIL-STD-2169A. A novel alternative approach for generation of the required signals, being developed in a cooperative effort between the Naval Air Warfare Center and Phillips Laboratory, is the use of white noise signals conditioned in such a manner to produce the desired direct drive waveforms.

Spheromak plasma flow injection into a torus chamber and the HIST plasmas

NASA Astrophysics Data System (ADS)

Hatuzaki, Akinori

2005-10-01

The importance of plasma flow or two-fluid effect is recognized in understanding the relaxed states of high-beta torus plasmas, start-up and current drive by non-coaxial helicity injection, magnetic reconnection and plasma dynamo in fusion, laboratory and space plasmas. As a new approach to create a flowing two-fluid plasma equilibrium, we have tried to inject tangentially the plasma flow with spheromak-type magnetic configurations into a torus vacuum chamber with an external toroidal magnetic field (TF) coil. In the initial experiments, the RFP-like configuration with helical magnetic structures was realized in the torus vessel. The ion flow measurement with Mach probes showed that the ion flow keeps the same direction despite the reversal of the toroidal current and the axial electric field. The ion fluid comes to flow in the opposite direction to the electron fluid by the reversal of TF. This result suggests that not only electron but also ion flow contributes significantly on the reversed toroidal current. In this case, the ratio of ui to the electron flow velocity ue is estimated as ui/ue ˜ 1/2. We also will inject the spheromak flow into the HIST spherical torus plasmas to examine the possibilities to embedding the two-fluid effect in the ST plasmas.

Ferroelectric Diodes with Charge Injection and Trapping

NASA Astrophysics Data System (ADS)

Fan, Zhen; Fan, Hua; Lu, Zengxing; Li, Peilian; Huang, Zhifeng; Tian, Guo; Yang, Lin; Yao, Junxiang; Chen, Chao; Chen, Deyang; Yan, Zhibo; Lu, Xubing; Gao, Xingsen; Liu, Jun-Ming

2017-01-01

Ferroelectric diodes with polarization-modulated Schottky barriers are promising for applications in resistive switching (RS) memories. However, they have not achieved satisfactory performance reliability as originally hoped. The physical origins underlying this issue have not been well studied, although they deserve much attention. Here, by means of scanning Kelvin probe microscopy we show that the electrical poling of ferroelectric diodes can cause significant charge injection and trapping besides polarization switching. We further show that the reproducibility and stability of switchable diode-type RS behavior are significantly affected by the interfacial traps. A theoretical model is then proposed to quantitatively describe the modifications of Schottky barriers by charge injection and trapping. This model is able to reproduce various types of hysteretic current-voltage characteristics as experimentally observed. It is further revealed that the charge injection and trapping can significantly modify the electroresistance ratio, RS polarity, and high- or low-resistance states initially defined by the polarization direction. Several approaches are suggested to suppress the effect of charge injection and trapping so as to realize high-performance polarization-reversal-induced RS. This study, therefore, reveals the microscopic mechanisms for the RS behavior comodulated by polarization reversal and charge trapping in ferroelectric diodes, and also provides useful suggestions for developing reliable ferroelectric RS memories.

In-situ droplet monitoring for self-tuning spectrometers

DOEpatents

Montaser, Akbar; Jorabchi, Kaveh; Kahen, Kaveh

2010-09-28

A laser scattering based imaging technique is utilized in order to visualize the aerosol droplets in an inductively coupled plasma (ICP) torch from an aerosol source to the site of analytical measurements. The resulting snapshots provide key information about the spatial distribution of the aerosol introduced by direct and indirect injection devices: 1) a direct injection high efficiency nebulizer (DIHEN); 2) a large-bore DIHEN (LB-DIHEN); and 3) a PFA microflow nebulizer with a PFA Scott-type spray chamber. Moreover, particle image velocimetry (PIV) is used to study the in-situ behavior of the aerosol before interaction with, for example, plasma, while the individual surviving droplets are explored by particle tracking velocimetry (PTV). Further, the velocity distribution of the surviving droplets demonstrates the importance of the initial droplet velocities in complete desolvation of the aerosol for optimum analytical performance in ICP spectrometries. These new observations are important in the design of the next-generation direct injection devices for lower sample consumption, higher sensitivity, lower noise levels, suppressed matrix effects, and for developing smart spectrometers. For example, a controller can be provided to control the output of the aerosol source by controlling the configuration of the source or the gas flow rate via feedback information concerning the aerosol.

Pressurized feed-injection spray-forming apparatus

DOEpatents

Berry, R.A.; Fincke, J.R.; McHugh, K.M.

1995-08-29

A spray apparatus and method are disclosed for injecting a heated, pressurized liquid in a first predetermined direction into a pressurized gas flow that is flowing in a second predetermined direction, to provide for atomizing and admixing the liquid with the gas to form a two-phase mixture. A valve is also disposed within the injected liquid conduit to provide for a pulsed injection of the liquid and timed deposit of the atomized gas phase. Preferred embodiments include multiple liquid feed ports and reservoirs to provide for multiphase mixtures of metals, ceramics, and polymers. 22 figs.

Pressurized feed-injection spray-forming apparatus

DOEpatents

Berry, Ray A.; Fincke, James R.; McHugh, Kevin M.

1995-01-01

A spray apparatus and method for injecting a heated, pressurized liquid in a first predetermined direction into a pressurized gas flow that is flowing in a second predetermined direction, to provide for atomizing and admixing the liquid with the gas to form a two-phase mixture. A valve is also disposed within the injected liquid conduit to provide for a pulsed injection of the liquid and timed deposit of the atomized gas phase. Preferred embodiments include multiple liquid feed ports and reservoirs to provide for multiphase mixtures of metals, ceramics, and polymers.

Control of Viscous Fingering in Miscible Displacements in Porous Media with a Periodic Change of Injection Rate

NASA Astrophysics Data System (ADS)

Yuan, Q.; Zeng, F.; Knorr, K. D.; Imran, M.

2017-12-01

Context/PurposeThe viscous fingering (VF) is widely encountered in a series of miscible displacements such as CO2 sequestration and solvent-based enhanced oil recovery (EOR). Accurate prediction and effective control of its development are significant. Commercial simulators cannot capture VF because of large numerical diffusion. Moreover, previous measures for controlling VF using polymer are very expensive. In the present study, a periodic change of injection rate involving injection and extraction is used to control and reduce VF instabilities at zero cost. MethodsHighly accurate spectral method and fully implicit alternating direction implicit method are used to simulate VF with concentration-dependent diffusion (CDD) and velocity-induced dispersion (VID), although the consideration of CDD and VID may result in strong nonlinearity and stiff problem under unfavourable viscosity ratio. In-house code is developed. The VF is reduced by optimizing period and amplitude of injection rate. ResultsThe results show that the periodic change of injection rates can strongly affect VF and sweep efficiency. In particular, a period-stabilizing range is found in which the VF is reduced compared with widely used constant injection with the same amount of fluid injected. The frequent change of rate results in high sweep efficiency. The optimal injection scheme, when compared with constant injection, can improve sweep efficiency by 20-35%. InterpretationDispersion plays a key role in the mitigation of VF in periodic displacement rates. It enhances the uniform mixing of two fluids in injection stage in any period, while it can more effectively attenuate VF instabilities through the following extraction stage. Fast switch of injection and extraction can mitigate flow instability once it develops. ConclusionThis finding is very novel and significant as it is the first time to control VF instability in porous media without any additional cost. It shows great potential for EOR at zero cost.

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

PubMed

Yu, Bofan; Song, Yonghui; Han, Lu; Yu, Huibin; Liu, Yang; Liu, Hongliang

2014-08-22

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromatography (LV-DAI-GC) method was optimized for the following parameters: packed sorbent for sample on-line pretreatment, inlet temperature and detectors configuration. Using the composite packed sorbent self-prepared with lithium chloride and a type of diatomite, the method enabled safe injection of an approximately 50-100 μL sample at an inlet temperature of 150 °C in the splitless mode and separated HVOCs from water matrix in 2 min. Coupled with a flame ionization detector (FID), an electron capture detector (ECD) and a flame photometric detector (FPD), the method could simultaneously quantify 27 HVOCs that belong to seven subclasses (i.e., halogenated aliphatic hydrocarbons, chlorobenzenes, nitrobenzenes, anilines, phenols, polycyclic aromatic hydrocarbons and organic sulfides) in 26 min. Injecting a 50 μL sample without any enrichment step, such as cryotrap focusing, the limits of quantification (LOQs) for the 27 HVOCs was 0.01-3 μg/L. Replicate analyses of the 27 HVOCs spiked source and river water samples exhibited good precision (relative standard deviations ≤ 11.3%) and accuracy (relative errors ≤ 17.6%). The optimized LV-DAI-GC was robust and applicable for fast determination and automated continuous monitoring of HVOCs in surface water. Copyright © 2014 Elsevier B.V. All rights reserved.

Expression of a model gene in prostate cancer cells lentivirally transduced in vitro and in vivo.

PubMed

Bastide, C; Maroc, N; Bladou, F; Hassoun, J; Maitland, N; Mannoni, P; Bagnis, C

2003-01-01

In a preclinical model for prostate cancer gene therapy, we have tested lentiviral vectors as a practical possibility for the transfer and long-term expression of the EGFP gene both in vitro and in vivo. The human prostate cancer cell lines DU145 and PC3 were transduced using experimental conditions which permitted analysis of the expression from a single proviral vector per cell. The transduced cells stably expressed the EGFP transgene for 4 months. After injection of the transduced cell populations into Nod-SCID mice a decrease in EGFP was only observed in a minority of cases, while the majority of tumors maintained transgene expression at in vitro levels. In vivo injection of viral vector preparations directly into pre-established subcutaneous or orthotopic tumor masses, obtained by implantation of untransduced PC3 and DU145 cells led to a high transduction efficiency. While the efficiency of direct intratumoral transduction was proportional to the dose of virus injected, the results indicated some technical limitations inherent in these approaches to prostate cancer gene therapy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zelenyuk, Alla; Reitz, Paul; Stewart, Mark L.

Gasoline Compression Ignition (GCI) engines have the potential to achieve high fuel efficiency and to significantly reduce both NOx and particulate matter (PM) emissions by operating under dilute partially-premixed conditions. This low temperature combustion strategy is dependent upon direct-injection of gasoline during the compression stroke and potentially near top dead center (TDC). The timing and duration of the in-cylinder injections can be tailored based on speed and load to create optimized conditions that result in a stable combustion. We present the results of advanced aerosol analysis methods that have been used for detailed real-time characterization of PM emitted from amore » single-cylinder GCI engine operated at different speed, load, timing, and number and duration of near-TDC fuel injections. PM characterization included 28 measurements of size and composition of individual particles sampled directly from the exhaust and after mass and/or mobility classification. We use these data to calculate particle effective density, fractal dimension, dynamic shape factors in free-molecular and transition flow regimes, average diameter of primary spherules, number of spherules, and void fraction of soot agglomerates.« less

Effects of film injection angle on turbine vane cooling

NASA Technical Reports Server (NTRS)

Gauntner, J. W.

1977-01-01

Film ejection from discrete holes in the suction surface of a turbine vane was studied for hole axes (1) slanted 30 deg to the surface in the streamwise direction and (2) slanted 30 deg to the surface and 45 deg from the streamwise direction toward the hub. The holes were near the throat area in a five-row staggered array with 8-diameter spacing. Mass flux ratios were as high as 1.2. The data were obtained in an annular sector cascade at conditions where both the ratio of the boundary layer momentum thickness-to-hole diameter and the momentum thickness Reynolds number were typical of an advanced turbofan engine at both takeoff and cruise. Wall temperatures were measured downstream of each of the rows of holes. Results of this study are expressed as a comparison of cooling effectiveness between the in-line angle injection and the compound-angle injection as a function of mass flux ratio. These heat transfer results are also compared with the results of a referenced flow visualization study. Also included is a closed-form analytical solution for temperature within the film cooled wall.

Directly tailoring photon-electron coupling for sensitive photoconductance

NASA Astrophysics Data System (ADS)

Huang, Zhiming; Zhou, Wei; Huang, Jingguo; Wu, Jing; Gao, Yanqing; Qu, Yue; Chu, Junhao

2016-03-01

The coupling between photons and electrons is at the heart of many fundamental phenomena in nature. Despite tremendous advances in controlling electrons by photons in engineered energy-band systems, control over their coupling is still widely lacking. Here we demonstrate an unprecedented ability to couple photon-electron interactions in real space, in which the incident electromagnetic wave directly tailors energy bands of solid to generate carriers for sensitive photoconductance. By spatially coherent manipulation of metal-wrapped material system through anti-symmetric electric field of the irradiated electromagnetic wave, electrons in the metals are injected and accumulated in the induced potential well (EIW) produced in the solid. Respective positive and negative electric conductances are easily observed in n-type and p-type semiconductors into which electrons flow down from the two metallic sides under light irradiation. The photoconductivity is further confirmed by sweeping the injected electrons out of the semiconductor before recombination applied by sufficiently strong electric fields. Our work opens up new perspectives for tailoring energy bands of solids and is especially relevant to develop high effective photon detection, spin injection, and energy harvesting in optoelectronics and electronics.

RF-to-DC Characteristics of Direct Irradiated On-Chip Gallium Arsenide Schottky Diode and Antenna for Application in Proximity Communication System

PubMed Central

Mustafa, Farahiyah; Hashim, Abdul Manaf

2014-01-01

We report the RF-to-DC characteristics of the integrated AlGaAs/GaAs Schottky diode and antenna under the direct injection and irradiation condition. The conversion efficiency up to 80% under direct injection of 1 GHz signal to the diode was achieved. It was found that the reduction of series resistance and parallel connection of diode and load tend to lead to the improvement of RF-to-DC conversion efficiency. Under direct irradiation from antenna-to-antenna method, the output voltage of 35 mV was still obtainable for the distance of 8 cm between both antennas in spite of large mismatch in the resonant frequency between the diode and the connected antenna. Higher output voltage in volt range is expected to be achievable for the well-matching condition. The proposed on-chip AlGaAs/GaAs HEMT Schottky diode and antenna seems to be a promising candidate to be used for application in proximity communication system as a wireless low power source as well as a highly sensitive RF detector. PMID:24561400

Magnetic reconnection process in transient coaxial helicity injection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebrahimi, F.; Hooper, E. B.; Sovinec, C. R.

The physics of magnetic reconnection and fast flux closure in transient coaxial helicity injection experiments in NSTX is examined using resistive MHD simulations. These simulations have been performed using the NIMROD code with fixed boundary flux (including NSTX poloidal coil currents) in the NSTX experimental geometry. Simulations show that an X point is formed in the injector region, followed by formation of closed flux surfaces within 0.5 ms after the driven injector voltage and injector current begin to rapidly decrease. As the injector voltage is turned off, the field lines tend to untwist in the toroidal direction and magnetic fieldmore » compression exerts a radial J × B force and generates a bi-directional radial E{sub toroidal}×B{sub poloidal} pinch flow to bring oppositely directed field lines closer together to reconnect. At sufficiently low magnetic diffusivity (high Lundquist number), and with a sufficiently narrow injector flux footprint width, the oppositely directed field lines have sufficient time to reconnect (before dissipating), leading to the formation of closed flux surfaces. The reconnection process is shown to have transient Sweet-Parker characteristics.« less

Control of the low-load region in partially premixed combustion

NASA Astrophysics Data System (ADS)

Ingesson, Gabriel; Yin, Lianhao; Johansson, Rolf; Tunestal, Per

2016-09-01

Partially premixed combustion (PPC) is a low temperature, direct-injection combustion concept that has shown to give promising emission levels and efficiencies over a wide operating range. In this concept, high EGR ratios, high octane-number fuels and early injection timings are used to slow down the auto-ignition reactions and to enhance the fuel and are mixing before the start of combustion. A drawback with this concept is the combustion stability in the low-load region where a high octane-number fuel might cause misfire and low combustion efficiency. This paper investigates the problem of low-load PPC controller design for increased engine efficiency. First, low-load PPC data, obtained from a multi-cylinder heavy- duty engine is presented. The data shows that combustion efficiency could be increased by using a pilot injection and that there is a non-linearity in the relation between injection and combustion timing. Furthermore, intake conditions should be set in order to avoid operating points with unfavourable global equivalence ratio and in-cylinder temperature combinations. Model predictive control simulations were used together with a calibrated engine model to find a gas-system controller that fulfilled this task. The findings are then summarized in a suggested engine controller design. Finally, an experimental performance evaluation of the suggested controller is presented.

Demountable direct injection high efficiency nebulizer for inductively coupled plasma mass spectrometry

DOEpatents

Montaser, Akbar; Westphal, Craig S.; Kahen, Kaveh; Rutkowski, William F.; Acon, Billy W.

2006-12-05

A nebulizer adapted for adjusting a position of a capillary tube contained within the nebulizer is provided. The nebulizer includes an elongated tubular shell having a gas input port and a gas output port, a capillary adjustment adapter for displacing the capillary tube in a lateral direction via a rotational force, and a connector for connecting the elongated tubular shell, the capillary adjustment adapter and the capillary tube.

Comparison of long-term voice outcomes after vocal fold augmentation using autologous fat injection by direct microlaryngoscopy versus office-based calcium hydroxylapatite injection.

PubMed

Zeleník, Karol; Walderová, Radana; Kučová, Hana; Jančatová, Debora; Komínek, Pavel

2017-08-01

The objective is to compare the long-term voice outcomes of vocal fold augmentation (VFA) using autologous fat injection via direct microlaryngoscopy versus office-based calcium hydroxylapatite (CaHA) injection. Patients with glottal insufficiency and a gap no greater than 3 mm caused by unilateral vocal fold paralysis or vocal fold atrophy were prospectively recruited to the study from September 2012 to September 2015. From September 2012 to May 2014, VFA was only performed using autologous fat via direct microlaryngoscopy under general anesthesia (N = 14). From May 2014 to September 2015, VFA was performed as an office-based procedure using a transoral approach to inject CaHA (N = 17). Videolaryngostroboscopic evaluation, subjective satisfaction with voice, voice handicap index (VHI), and maximal phonation time (MPT) were analyzed pre-injection and 12 months after VFA. A total of 31 patients were analyzed. One year after VFA, 67.8% of the patients were satisfied with their voice, with no significant difference between groups (P = 0.247). The mean improvement in VHI in the autologous fat group was 31.6 ± 16.82 versus 35 ± 27.24 in the CaHA group (P = 0.664). MPT improvement was also similar in the two groups: 5.5 ± 2.52 for the autologous fat group versus 6.0 ± 3.98 for the CaHA group (P = 0.823). Both autologous fat injection via direct microlaryngoscopy and office-based CaHA injection have good long-term results. There were no differences in the treatment results of the two procedures 1 year after injection.

Advanced Imaging Adds Little Value in the Diagnosis of Femoroacetabular Impingement Syndrome.

PubMed

Cunningham, Daniel J; Paranjape, Chinmay S; Harris, Joshua D; Nho, Shane J; Olson, Steven A; Mather, Richard C

2017-12-20

Femoroacetabular impingement (FAI) syndrome is an increasingly recognized source of hip pain and disability in young active adults. In order to confirm the diagnosis, providers often supplement physical examination maneuvers and radiographs with intra-articular hip injection, magnetic resonance imaging (MRI), or magnetic resonance arthrography (MRA). Since diagnostic imaging represents the fastest rising cost segment in U.S. health care, there is a need for value-driven diagnostic algorithms. The purpose of this study was to identify cost-effective diagnostic strategies for symptomatic FAI, comparing history and physical examination (H&P) alone (utilizing only radiographic imaging) with supplementation with injection, MRI, or MRA. A simple-chain decision model run as a cost-utility analysis was constructed to assess the diagnostic value of the MRI, MRA, and injection that are added to the H&P and radiographs in diagnosing symptomatic FAI. Strategies were compared using the incremental cost-utility ratio (ICUR) with a willingness to pay (WTP) of $100,000/QALY (quality-adjusted life year). Direct costs were measured using the Humana database (PearlDiver). Diagnostic test accuracy, treatment outcome probabilities, and utilities were extracted from the literature. H&P with and without supplemental diagnostic injection was the most cost-effective. Adjunct injection was preferred in situations with a WTP of >$60,000/QALY, low examination sensitivity, and high FAI prevalence. With low disease prevalence and low examination sensitivity, as may occur in a general practitioner's office, H&P with injection was the most cost-effective strategy, whereas in the reciprocal scenario, H&P with injection was only favored at exceptionally high WTP (∼$990,000). H&P and radiographs with supplemental diagnostic injection are preferred over advanced imaging, even with reasonable deviations from published values of disease prevalence, test sensitivity, and test specificity. Providers with low examination sensitivity in situations with low disease prevalence may benefit most from including injection in their diagnostic strategy. Providers with high examination sensitivity in situations with high disease prevalence may not benefit from including injection in their diagnostic strategy. Providers should not routinely rely on advanced imaging to diagnose FAI syndrome, although advanced imaging may have a role in challenging clinical scenarios. Economic and Decision Analysis Level IV. See Instructions for Authors for a complete description of levels of evidence.

Teduglutide Injection

MedlinePlus

... the medication should read the manufacturer's directions for mixing and injecting the medication before you use it ... Teduglutide must be used within 3 hours after mixing teduglutide powder with the diluent.You can inject ...

Method for operating a spark-ignition, direct-injection internal combustion engine

DOEpatents

Narayanaswamy, Kushal; Koch, Calvin K.; Najt, Paul M.; Szekely, Jr., Gerald A.; Toner, Joel G.

2015-06-02

A spark-ignition, direct-injection internal combustion engine is coupled to an exhaust aftertreatment system including a three-way catalytic converter upstream of an NH3-SCR catalyst. A method for operating the engine includes operating the engine in a fuel cutoff mode and coincidentally executing a second fuel injection control scheme upon detecting an engine load that permits operation in the fuel cutoff mode.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zou, P.; Fang, C.; Chen, P. F.

Solar filaments can be formed via chromospheric evaporation followed by condensation in the corona or by the direct injection of cool plasma from the chromosphere to the corona. We here confirm with high-resolution H α data observed by the 1.6 m New Solar Telescope of the Big Bear Solar Observatory on 2015 August 21 that an active-region filament is maintained by the continuous injection of cold chromospheric plasma. We find that the filament is rooted along a bright ridge in H α , which corresponds to the intersection of a magnetic quasi-separatrix layer with the solar surface. This bright ridgemore » consists of many small patches whose sizes are comparable to the width of the filament threads. It is found that upflows originate from the brighter patches of the ridge, whereas the downflows move toward the weaker patches of the ridge. The whole filament is composed of two opposite-direction streams, implying that longitudinal oscillations are not the only cause of the counterstreamings, and unidirectional siphon flows with alternative directions are another possibility.« less

Two Azimuthally Separated Regions of Cusp Ion Injection Observed via Energetic Neutral Atoms

NASA Technical Reports Server (NTRS)

Abe, M.; Taguchi, S.; Collier, M. R.; Moore, T. E.

2011-01-01

The low-energy neutral atom (LENA) imager on the IMAGE spacecraft can detect energetic neutral atoms produced by ion injection into the cusp through a charge exchange with the Earth's hydrogen exosphere. We examined the occurrence of the LENA cusp signal during positive IMF B(sub z) in terms of the arrival direction and the IMF clock angle theta(sub CA). Results of statistical analyses show that the occurrence frequency is high on the postnoon side when theta(sub CA) is between approximately 20 degrees and approximately 50 degrees. This is ascribed to ion injection caused by cusp reconnection typical of positive IMF B(sub z). Our results also show that there is another situation of high occurrence frequency, which can be identified with theta(sub CA) of approximately 30 degrees to approximately 80 degrees. When theta(sub CA) is relatively large (60 degrees - 80 degrees), occurrence frequencies are high at relatively low latitudes over a wide extent spanning both prenoon and postnoon sectors. This feature suggests that the ion injection is caused by reconnection at the dayside magnetopause. Its postnoon side boundary shifts toward the prenoon as theta(sub CA) decreases. When theta(sub CA) is less than approximately 50 degrees, the high occurrence frequency exists well inside the prenoon sector, which is azimuthally separated from the postnoon region ascribed to cusp reconnection. The prenoon region, which is thought due to ion injection caused by dayside reconnection, may explain the recent report that proton aurora brightening occurs in the unanticipated prenoon sector of the northern high-latitude ionosphere for IMF B(sub y) greater than 0 and B(sub z) greater than 0.

Plasma Rotation During Neutral Beam Injection In MST

NASA Astrophysics Data System (ADS)

Hudson, Ben; Ding, W.; Fiksel, G.; Prager, S.; Yates, T.

2006-10-01

The effect of fast ions from neutral beam injection (20 keV, 30 A, 1.5 ms) on plasma rotation and magnetic tearing modes is studied. We observe that during co-injected NBI (with the injection in the same direction as the plasma and mode rotation) the rotation of the core-resonant n = 5 magnetic mode decreases and in many instances lock to the vessel wall. There is an associated drop in the poloidal component of n = 5 magnetic mode amplitude. The drop in the mode velocity suggests a counter-directed torque, perhaps due to modification of the radial electric field. The rotation slows during the injection phase, then restores itself on the timescale of the fast ion slowing down time (5 ms @ Te = 100 eV). The fluctuation-induced j x b Maxwell stress is measured using MST's FIR diagnostic and presented for comparison. Equilibrium reconstruction suggests a small increase in on-axis J||, consistent with the presence of a localized fast ion population moving in the direction of the plasma current. Mode rotation during NBI counter-injection is also presented.

Direct Acceleration of Pickup Ions at The Solar Wind Termination Shock: The Production of Anomalous Cosmic Rays

NASA Technical Reports Server (NTRS)

Ellison, Donald C.; Jones, Frank C.; Baring, Matthew G.

1998-01-01

We have modeled the injection and acceleration of pickup ions at the solar wind termination shock and investigated the parameters needed to produce the observed Anomalous Cosmic Ray (ACR) fluxes. A non-linear Monte Carlo technique was employed, which in effect solves the Boltzmann equation and is not restricted to near-isotropic particle distribution functions. This technique models the injection of thermal and pickup ions, the acceleration of these ions, and the determination of the shock structure under the influence of the accelerated ions. The essential effects of injection are treated in a mostly self-consistent manner, including effects from shock obliquity, cross- field diffusion, and pitch-angle scattering. Using recent determinations of pickup ion densities, we are able to match the absolute flux of hydrogen in the ACRs by assuming that pickup ion scattering mean free paths, at the termination shock, are much less than an AU and that modestly strong cross-field diffusion occurs. Simultaneously, we match the flux ratios He(+)/H(+) or O(+)/H(+) to within a factor approx. 5. If the conditions of strong scattering apply, no pre-termination-shock injection phase is required and the injection and acceleration of pickup ions at the termination shock is totally analogous to the injection and acceleration of ions at highly oblique interplanetary shocks recently observed by the Ulysses spacecraft. The fact that ACR fluxes can be modeled with standard shock assumptions suggests that the much-discussed "injection problem" for highly oblique shocks stems from incomplete (either mathematical or computer) modeling of these shocks rather than from any actual difficulty shocks may have in injecting and accelerating thermal or quasi-thermal particles.

Ultra low injection angle fuel holes in a combustor fuel nozzle

DOEpatents

York, William David

2012-10-23

A fuel nozzle for a combustor includes a mixing passage through which fluid is directed toward a combustion area and a plurality of swirler vanes disposed in the mixing passage. Each swirler vane of the plurality of swirler vanes includes at least one fuel hole through which fuel enters the mixing passage in an injection direction substantially parallel to an outer surface of the plurality of swirler vanes thereby decreasing a flameholding tendency of the fuel nozzle. A method of operating a fuel nozzle for a combustor includes flowing a fluid through a mixing passage past a plurality of swirler vanes and injecting a fuel into the mixing passage in an injection direction substantially parallel to an outer surface of the plurality of swirler vanes.

INTERNATIONAL CONFERENCE ON SEMICONDUCTOR INJECTION LASERS SELCO-87: High-frequency impedance and spontaneous carrier lifetime in narrow-stripe semiconductor injection lasers

NASA Astrophysics Data System (ADS)

Hoernlein, W.

1988-11-01

Measurements were made of the complex reflection coefficient of hf (10-400 MHz) signals from semiconductor injection lasers supplied with a direct bias current ranging from several milliamperes up to the threshold value or higher. The hf impedance was calculated. The parameters of the equivalent electrical circuit made it possible to predict the modulation characteristics. The impedance corresponding to currents below the lasing threshold was used to find the differential carrier lifetime from the RC constant of the p-n junction of a laser diode. A description of the apparatus is supplemented by an account of the method used in calculation of the electrical parameters and carrier lifetimes. The first results obtained using this apparatus and method are reported.

Method and apparatus to produce high specific impulse and moderate thrust from a fusion-powered rocket engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, Samuel A.; Pajer, Gary A.; Paluszek, Michael A.

A system and method for producing and controlling high thrust and desirable specific impulse from a continuous fusion reaction is disclosed. The resultant relatively small rocket engine will have lower cost to develop, test, and operate that the prior art, allowing spacecraft missions throughout the planetary system and beyond. The rocket engine method and system includes a reactor chamber and a heating system for heating a stable plasma to produce fusion reactions in the stable plasma. Magnets produce a magnetic field that confines the stable plasma. A fuel injection system and a propellant injection system are included. The propellant injectionmore » system injects cold propellant into a gas box at one end of the reactor chamber, where the propellant is ionized into a plasma. The propellant and fusion products are directed out of the reactor chamber through a magnetic nozzle and are detached from the magnetic field lines producing thrust.« less

Fracture Propagation, Fluid Flow, and Geomechanics of Water-Based Hydraulic Fracturing in Shale Gas Systems and Electromagnetic Geophysical Monitoring of Fluid Migration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Jihoon; Um, Evan; Moridis, George

2014-12-01

We investigate fracture propagation induced by hydraulic fracturing with water injection, using numerical simulation. For rigorous, full 3D modeling, we employ a numerical method that can model failure resulting from tensile and shear stresses, dynamic nonlinear permeability, leak-off in all directions, and thermo-poro-mechanical effects with the double porosity approach. Our numerical results indicate that fracture propagation is not the same as propagation of the water front, because fracturing is governed by geomechanics, whereas water saturation is determined by fluid flow. At early times, the water saturation front is almost identical to the fracture tip, suggesting that the fracture is mostlymore » filled with injected water. However, at late times, advance of the water front is retarded compared to fracture propagation, yielding a significant gap between the water front and the fracture top, which is filled with reservoir gas. We also find considerable leak-off of water to the reservoir. The inconsistency between the fracture volume and the volume of injected water cannot properly calculate the fracture length, when it is estimated based on the simple assumption that the fracture is fully saturated with injected water. As an example of flow-geomechanical responses, we identify pressure fluctuation under constant water injection, because hydraulic fracturing is itself a set of many failure processes, in which pressure consistently drops when failure occurs, but fluctuation decreases as the fracture length grows. We also study application of electromagnetic (EM) geophysical methods, because these methods are highly sensitive to changes in porosity and pore-fluid properties due to water injection into gas reservoirs. Employing a 3D finite-element EM geophysical simulator, we evaluate the sensitivity of the crosswell EM method for monitoring fluid movements in shaly reservoirs. For this sensitivity evaluation, reservoir models are generated through the coupled flow-geomechanical simulator and are transformed via a rock-physics model into electrical conductivity models. It is shown that anomalous conductivity distribution in the resulting models is closely related to injected water saturation, but not closely related to newly created unsaturated fractures. Our numerical modeling experiments demonstrate that the crosswell EM method can be highly sensitive to conductivity changes that directly indicate the migration pathways of the injected fluid. Accordingly, the EM method can serve as an effective monitoring tool for distribution of injected fluids (i.e., migration pathways) during hydraulic fracturing operations« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jung, Hee Joon; Edwards, Dan J.; Kurtz, Richard J.

An investigation of the influence of helium on damage evolution under neutron irradiation of an 11 at% Al, 19 at% Cr ODS ferritic PM2000 alloy was carried out in the High Flux Isotope Reactor (HFIR) using a novel in situ helium injection (ISHI) technique. Helium was injected into adjacent TEM discs from thermal neutron 59Ni(nth, 59Ni(nth,α) reactions in a thin NiAl layer. The PM2000 undergoes concurrent displacement damage from the high-energy neutrons. The ISHI technique allows direct comparisons of regions with and without high concentrations of helium since only the side coated with the NiAl experiences helium injection. The correspondingmore » microstructural and microchemical evolutions were characterized using both conventional and scanning transmission electron microscopy techniques. The evolutions observed include formation of dislocation loops and associated helium bubbles, precipitation of a variety of phases, amorphization of the Al2YO3 oxides (which also variously contained internal voids), and several manifestations of solute segregation. Notably, high concentrations of helium had a significant effect on many of these diverse phenomena. These results on PM2000 are compared and contrasted to the evolution of so-called nanostructured ferritic alloys (NFA).« less

Efficient Color-Stable Inverted White Organic Light-Emitting Diodes with Outcoupling-Enhanced ZnO Layer.

PubMed

Zhao, Xin-Dong; Li, Yan-Qing; Xiang, Heng-Yang; Zhang, Yi-Bo; Chen, Jing-De; Xu, Lu-Hai; Tang, Jian-Xin

2017-01-25

Inverted organic light-emitting diode (OLED) has attracted extensive attention due to the demand in active-matrix OLED display panels as its geometry enables the direct connection with n-channel transistor backplane on the substrate. One key challenge of high-performance inverted OLED is an efficient electron-injection layer with superior electrical and optical properties to match the indium tin oxide cathode on substrate. We here propose a synergistic electron-injection architecture using surface modification of ZnO layer to simultaneously promote electron injection into organic emitter and enhance out-coupling of waveguided light. An efficient inverted white OLED is realized by introducing the nanoimprinted aperiodic nanostructure of ZnO for broadband and angle-independent light out-coupling and inserting an n-type doped interlayer for energy level tuning and injection barrier lowering. As a result, the optimized inverted white OLEDs have an external quantum efficiency of 42.4% and a power efficiency of 85.4 lm W 1- , which are accompanied by the superiority of angular color stability over the visible wavelength range. Our results may inspire a promising approach to fabricate high-efficiency inverted OLEDs for large-scale display panels.

Intraoperative Transpedicular Onyx Injection to Reduce Vascularity of a Thoracic Hemangiopericytoma After Unsuccessful Preoperative Endovascular Embolization: a Technical Report.

PubMed

Mashaly, Hazem; Zhang, Zoe; Shaw, Andrew; Youssef, Patrick; Mendel, Ehud

2018-02-01

Hemangiopericytoma is a rare vascular tumor with central nervous system involvement representing only 1% of central nervous system tumors. They rarely affect the vertebral column. Complete surgical resection is the treatment of choice for hemangiopericytoma given their high rates of local recurrence. However, the high vascularity of such tumors with the risk of massive bleeding during surgery represents a significant challenge to surgeons. Therefore, preoperative endovascular embolization via the transarterial route has been advocated. In the current study, we present a case of a T12 hemangiopericytoma that was managed by a 2-stage surgical resection, with the use of intraoperative transpedicular onyx injection to reduce intraoperative blood loss following an unsuccessful trial of preoperative endovascular embolization. Preoperative endovascular embolization is not feasible in some cases due to the location of the segmental or radiculomedullary arteries in relation to tumor feeders and, rarely, small size of these arterial feeders. Percutaneous injection of onyx is an option. In this case report, we discuss direct intraoperative injection via a transpedicular route as a safe and effective method for decreasing the vascularity of some lesions and improving intraoperative blood loss. Copyright © 2017 by the Congress of Neurological Surgeons

Phase measurement by using a forced delay-line oscillator and its application for an acoustic fiber sensor.

PubMed

Fleyer, Michael; Horowitz, Moshe

2018-04-02

We demonstrate, theoretically and experimentally, a new method to measure small changes in the cavity length of oscillators. The method is based on the high sensitivity of the phase of forced delay-line oscillators to changes in their cavity length. The oscillator phase is directly detected by mixing the oscillator output with the injected signal. We describe a comprehensive theoretical model for studying the signal and the noise at the output of a general forced delay-line oscillator with an instantaneous gain saturation and an amplitude-to-phase conversion. The results indicate that the magnitude and the bandwidth of the oscillator response to a small perturbation can be controlled by adjusting the injection ratio and the injected frequency. For signals with a frequency that is smaller than the device bandwidth, the oscillator noise is dominated by the noise of the injected signal. This noise is highly suppressed by mixing the oscillator output with the injected signal. Hence, the device sensitivity at frequencies below its bandwidth is limited only by the internal noise that is added in a single roundtrip in the oscillator cavity. We demonstrate the use of a forced oscillator as an acoustic fiber sensor in an optoelectronic oscillator. A good agreement is obtained between theory and experiments. The magnitude of the output signal can be controlled by adjusting the injection ratio while the noise power at low frequencies is not enhanced as in sensors that are based on a free-running oscillator.

ANALYSIS OF VOLATILES AND SEMIVOLATILES BY DIRECT AQUEOUS INJECTION

EPA Science Inventory

Direct aqueous injection analysis (DAI) with gas chromatographic separation and ion trap mass spectral detection was used to analyze aqueous samples for g/L levels of 54 volatile and semivolatile compounds, and problematic non-purgeables and non-extractables. The method reduces ...

An egg injection technique to evaluate the effect of polychlorinated biphenyls on the hatching success of the snapping turtle (Chelydra serpentina serpentina).

PubMed

Schnars, Jeanette L; Voss, Margaret A; Stauffer, Jay R

2011-04-01

Embryos of oviparous organisms are exposed to contaminants by two pathways: contaminant uptake from the surrounding environment, and the transfer from female to offspring (maternal transfer). The initial source of contaminant exposure for most embryos is likely to be maternal transfer; therefore, maternal transfer studies are critical in determining the effects of contaminants on future populations. Injection of contaminants directly into eggs is one route of experimental contaminant exposure that permits controlled doses and potential reliable replication. This technique, however, has been used in the past with little success in reptiles. The objective of the present study was to evaluate egg injection as a means of mimicking maternal transfer of polychlorinated biphenyls (PCBs) to snapping turtle eggs. Eggs from several clutches were injected with a PCB solution and incubated at several temperatures and moisture levels to measure interactive effects of injection, environmental condition, and contaminant load on hatching success. The injection technique allowed for application of consistent and specific doses among replicates. Overall hatching success in this study was 61% and was as high as 71% within specific treatments. Hatching success was much higher in this study than in other studies using egg injections to mimic maternal transfer in chelonians and crocodilians. Copyright © 2010 SETAC.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sevik, James; Pamminger, Michael; Wallner, Thomas

Interest in natural gas as an alternative fuel source to petroleum fuels for light-duty vehicle applications has increased due to its domestic availability and stable price compared to gasoline. With its higher hydrogen-to-carbon ratio, natural gas has the potential to reduce engine out carbon dioxide emissions, which has shown to be a strong greenhouse gas contributor. For part-load conditions, the lower flame speeds of natural gas can lead to an increased duration in the inflammation process with traditional port-injection. Direct-injection of natural gas can increase in-cylinder turbulence and has the potential to reduce problems typically associated with port-injection of naturalmore » gas, such as lower flame speeds and poor dilution tolerance. A study was designed and executed to investigate the effects of direct-injection of natural gas at part-load conditions. Steady-state tests were performed on a single-cylinder research engine representative of current gasoline direct-injection engines. Tests were performed with direct-injection in the central and side location. The start of injection was varied under stoichiometric conditions in order to study the effects on the mixture formation process. In addition, exhaust gas recirculation was introduced at select conditions in order to investigate the dilution tolerance. Relevant combustion metrics were then analyzed for each scenario. Experimental results suggest that regardless of the injector location, varying the start of injection has a strong impact on the mixture formation process. Delaying the start of injection from 300 to 120°CA BTDC can reduce the early flame development process by nearly 15°CA. While injecting into the cylinder after the intake valves have closed has shown to produce the fastest combustion process, this does not necessarily lead to the highest efficiency, due to increases in pumping and wall heat losses. When comparing the two injection configurations, the side location shows the best performance in terms of combustion metrics and efficiencies. For both systems, part-load dilution tolerance is affected by the injection timing, due to the induced turbulence from the gaseous injection event. CFD simulation results have shown that there is a fundamental difference in how the two injection locations affect the mixture formation process. Delayed injection timing increases the turbulence level in the cylinder at the time of the spark, but reduces the available time for proper mixing. Side injection delivers a gaseous jet that interacts more effectively with the intake induced flow field, and this improves the engine performance in terms of efficiency.« less

Carbon microgranule injection into NSTX-U discharges for edge diagnostic research

NASA Astrophysics Data System (ADS)

Lunsford, Robert; Roquemore, A. Lane; Scotti, Filippo; Mansfield, Dennis; Bortolon, Alessandro; Kaita, Robert; Maingi, Rajesh

2016-10-01

Microgranule injection is a versatile means for investigating edge plasmas in fusion devices. Employing a dual bladed rotary turbine, carbon microgranules ranging in diameter from 300 - 700 microns are radially injected into NSTX-U discharges at approximately 50 m/sec. Utilizing multiple high speed camera views, a 3D reconstruction of the injection geometry is created which characterizes the ablation rate and granule trajectory. By coupling this with a neutral gas shielding (NGS) ablation model, the granule mass deposition profile can be determined. Simulation projects a depositional barycenter near the pedestal shoulder for H-mode discharges, and 20 cm inboard of the LCFS for L-mode discharges. Spectroscopic measurements of this localized particle source can be used to characterize impurity transport within the discharge, and potentially allows for direct measurement of the safety factor profile (q). In addition, the transient pressure peaking resultant from injection into H-mode plasmas can also result in the prompt triggering of an edge localized mode (ELM). Work supported by DOE Contract No. DE-AC02-09CH11466.

Injection and waveguiding properties in SU8 nanotubes for sub-wavelength regime propagation and nanophotonics integration

NASA Astrophysics Data System (ADS)

Bigeon, John; Huby, Nolwenn; Duvail, Jean-Luc; Bêche, Bruno

2014-04-01

We report photonic concepts related to injection and sub-wavelength propagation in nanotubes, an unusual but promising geometry for highly integrated photonic devices. Theoretical simulation by the finite domain time-dependent (FDTD) method was first used to determine the features of the direct light injection and sub-wavelength propagation regime within nanotubes. Then, the injection into nanotubes of SU8, a photoresist used for integrated photonics, was successfully achieved by using polymer microlensed fibers with a sub-micronic radius of curvature, as theoretically expected from FDTD simulations. The propagation losses in a single SU8 nanotube were determined by using a comprehensive set-up and a protocol for optical characterization. The attenuation coefficient has been evaluated at 1.25 dB mm-1 by a cut-back method transposed to such nanostructures. The mechanisms responsible for losses in nanotubes were identified with FDTD theoretical support. Both injection and cut-back methods developed here are compatible with any sub-micronic structures. This work on SU8 nanotubes suggests broader perspectives for future nanophotonics.

Injection and waveguiding properties in SU8 nanotubes for sub-wavelength regime propagation and nanophotonics integration.

PubMed

Bigeon, John; Huby, Nolwenn; Duvail, Jean-Luc; Bêche, Bruno

2014-05-21

We report photonic concepts related to injection and sub-wavelength propagation in nanotubes, an unusual but promising geometry for highly integrated photonic devices. Theoretical simulation by the finite domain time-dependent (FDTD) method was first used to determine the features of the direct light injection and sub-wavelength propagation regime within nanotubes. Then, the injection into nanotubes of SU8, a photoresist used for integrated photonics, was successfully achieved by using polymer microlensed fibers with a sub-micronic radius of curvature, as theoretically expected from FDTD simulations. The propagation losses in a single SU8 nanotube were determined by using a comprehensive set-up and a protocol for optical characterization. The attenuation coefficient has been evaluated at 1.25 dB mm(-1) by a cut-back method transposed to such nanostructures. The mechanisms responsible for losses in nanotubes were identified with FDTD theoretical support. Both injection and cut-back methods developed here are compatible with any sub-micronic structures. This work on SU8 nanotubes suggests broader perspectives for future nanophotonics.

Numerical Investigation Into Effect of Fuel Injection Timing on CAI/HCCI Combustion in a Four-Stroke GDI Engine

NASA Astrophysics Data System (ADS)

Cao, Li; Zhao, Hua; Jiang, Xi; Kalian, Navin

2006-02-01

The Controlled Auto-Ignition (CAI) combustion, also known as Homogeneous Charge Compression Ignition (HCCI), was achieved by trapping residuals with early exhaust valve closure in conjunction with direct injection. Multi-cycle 3D engine simulations have been carried out for parametric study on four different injection timings in order to better understand the effects of injection timings on in-cylinder mixing and CAI combustion. The full engine cycle simulation including complete gas exchange and combustion processes was carried out over several cycles in order to obtain the stable cycle for analysis. The combustion models used in the present study are the Shell auto-ignition model and the characteristic-time combustion model, which were modified to take the high level of EGR into consideration. A liquid sheet breakup spray model was used for the droplet breakup processes. The analyses show that the injection timing plays an important role in affecting the in-cylinder air/fuel mixing and mixture temperature, which in turn affects the CAI combustion and engine performance.

Delivering direct acting antiviral therapy for hepatitis C to highly marginalised and current drug injecting populations in a targeted primary health care setting.

PubMed

Read, Phillip; Lothian, Rebecca; Chronister, Karen; Gilliver, Rosie; Kearley, John; Dore, Gregory J; van Beek, Ingrid

2017-09-01

The Kirketon Road Centre (KRC) is a community-based public health facility in Sydney, Australia, that provides healthcare to people who inject drugs (PWID), including hepatitis C virus (HCV) treatment. From March 2016, the Australian Government has provided access to direct-acting antivirals (DAA) for adults with chronic HCV, without liver disease stage or drug and alcohol use restrictions. The aim of this study was to report DAA treatment outcomes among highly marginalised PWID treated at KRC. All individuals initiating DAA treatment at KRC and due for sustained virological response (SVR12) testing by end 2016 were included. Demographic, drug use behaviour, clinical parameters, adherence support and HCV treatment outcomes, including SVR12 were recorded. Factors associated with SVR12, loss-to-follow-up (LTFU) and delayed SVR12 testing (>SVR16) were assessed by multivariate analysis. SVR12 was assessed by intention-to-treat (ITT) and modified ITT, the latter excluding individuals with an end-of-treatment response (ETR) but no SVR12 assessment, or who postponed their SVR12 date due to treatment interruption. A total of 72 individuals commencing DAAs were included, of whom 67% were male, 30% homeless, and 32% Aboriginal. All had a lifetime history of injecting drug use, with 75% having injected within the last six months, and 44% injecting at least weekly; 25% were also enrolled in opioid substitution therapy. Twenty-five (35%) individuals elected to receive an enhanced adherence-support package. Fifty-nine of 72 (82%) individuals due for SVR12 attended for testing, of whom 59/59 (100%) achieved SVR, providing an ITT SVR of 82%. A further six individuals had undetectable HCV RNA at ETR, but no SVR12 assessment, and one interrupted treatment, providing a mITT SVR of 91%. Homelessness was associated with delayed SVR12 testing (OR 24.9 95%CI 2.9-212.8, p=0.003). There was no association between LTFU and frequency of drug injection, last drug injected, or planned treatment duration. This study confirms that PWID can be successfully treated for HCV in a real-world setting using an integrated primary health care model. It also demonstrates feasibility to upscale DAA therapy in high-risk PWID populations, with potential individual and population-level public health benefits. Enhanced efforts are required to optimise post-treatment follow-up. Copyright © 2017 Elsevier B.V. All rights reserved.

Ultra-trace level determination of diquat and paraquat residues in surface and drinking water using ion-pair liquid chromatography with tandem mass spectrometry: a comparison of direct injection and solid-phase extraction methods.

PubMed

Oh, Jin-Aa; Lee, Jun-Bae; Lee, Soo-Hyung; Shin, Ho-Sang

2014-10-01

Direct injection and solid-phase extraction methods for the determination of diquat and paraquat in surface and drinking water were developed using liquid chromatography with tandem mass spectrometry. The signal intensities of analytes based on six ion-pairing reagents were compared with each other, and 12.5 mM nonafluoropentanoic acid was selected as the best suited amongst them. A clean-up method was developed using Oasis hydrophilic-lipophilic balance; this was compared to the direct injection method, with respect to limits of detection, interference, precision, and accuracy. Limits of quantification of diquat and paraquat were 0.03 and 0.01 μg/L using the direct injection method, and 0.002 and 0.001 μg/L using the hydrophilic-lipophilic balance method. When the hydrophilic-lipophilic balance method was used to analyze target compounds in 114 surface water and 30 drinking water samples, paraquat and diquat were detected within a concentration range of 0.001-0.12 and 0.002-0.038 μg/L in surface water, respectively. When the direct injection method was used to analyze target compounds in the same samples, the detected concentrations of paraquat and diquat were within 25% in samples being >0.015 μg/L using the hydrophilic-lipophilic balance method. The liquid chromatography with tandem mass spectrometry method using direct injection can thus be used for routine monitoring of paraquat and diquat in surface and drinking water. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Relationship Between the Provision of Injection Services in Ambulatory Physician Offices and Prescribing Injectable Medicines.

PubMed

Yousefi, Naeimeh; Rashidian, Arash; Soleymani, Fatemeh; Kebriaeezade, Abbas

2017-01-01

Overuse of injections is a common problem in many low-income and middle income countries. While cultural factors and attitudes of both physicians and patients are important factors, physicians› financial intensives may play an important role in overprescribing of injections. This study was designed to assess the effects of providing injection- services in physicians› ambulatory offices on prescribing injectable medicines. This cross-sectional study was conducted in Tehran in 2012 -2013and included a random sample of general physicians, pediatricians and infectious disease specialists. We collected data on the provision of injection services in or in proximity of physician offices, and obtained data from physicians› prescriptions in the previous three-month period. We analyzed the data using ANOVA, Student›s t-test and linear regression methods. We obtained complete data from 465 of 600 sampled physicians. Overall 41.9% of prescriptions contained injectable medicines. 75% of physicians offered injection services in their offices. Male physicians and general physicians were more likely to offer the services, and more likely to prescribe injectables. We observed a clear linear relationship between the injection service working hours and the proportion of prescriptions containing injectables (p-value<0.001). Providing injection service in the office was directly linked with the proportion of prescriptions containing injectables. While provision of injection services may provide a direct financial benefit to physicians, it is unlikely to be able to substantially reduce injectable medicines› prescription without addressing the issue.

The directional dependence of cometary magnetic energy density in the quasi-parallel and quasi-perpendicular regimes

NASA Technical Reports Server (NTRS)

Miller, R. H.; Gombosi, T. I.; Gary, S. P.; Winske, D.

1991-01-01

The direction of propagation of low frequency magnetic fluctuations generated by cometary ion pick-up is examined by means of 1D electromagnetic hybrid simulations. The newborn ions are injected at a constant rate, and the helicity and direction of propagation of magnetic fluctuations are explored for cometary ion injection angles of 0 and 90 deg relative to the solar wind magnetic field. The parameter eta represents the relative contribution of wave energy propagating in the direction away from the comet, parallel to the beam. For small (quasi-parallel) injection angles eta was found to be of order unity, while for larger (quasi-perpendicular) angles eta was found to be of order 0.5.

Monitoring an EGS injection at Newberry Volcano using Magnetotelluric dimensionality analysis

NASA Astrophysics Data System (ADS)

Bowles-martinez, E.; Schultz, A.; Rose, K.; Urquhart, S.

2016-12-01

The sensitivity of magnetotelluric (MT) data to the presence of electrically conductive subsurface features makes it applicable for determining the extent of injected fluids in enhanced geothermal systems (EGS). We use MT to monitor fluid injection during tests of a proposed EGS site at Newberry Volcano in Central Oregon, USA. Newberry is a large shield volcano located where fault systems of the northern Basin and Range meet the Cascade Arc and the high lava plains. Its strong potential for geothermal energy has made it a target for energy exploration for over 40 years. MT measurements were made before, during, and after an EGS stimulation in 2014 in an effort to detect subsurface pathways taken by fluids that are attributable to stimulation. We begin by creating a baseline model from inverting over 200 wideband MT stations located in the western half of the volcano. This model is constrained by well logs, as well as by high resolution gravity and seismic velocity modeling. Our model shows conductive regions associated with the caldera's ring fault, likely showing where hydrothermal fluids or their mineral alteration products are present. However, as this is an EGS study, we are interested in detecting fluid intrusion into hot, dry rock. Therefore, our primary target is a resistive zone on the western flank of Newberry volcano that is interpreted as a series of hot intrusive sequences. Well bottom temperatures in this area have been measured in excess of 300 °C. The stimulation's effect on resistivity is subtle, in part because the injected fluid is fresh groundwater, the injected volume is modest, and the target depth is 2,000-3,000 m below ground level. We found that it is advantageous to look at the impedance tensor data directly to detect injected fluids. Because fluids and their associated change in resistivity are expected to be concentrated around the injection well, the injection will exhibit a highly three-dimensional resistivity structure. Therefore, we examine the impedance tensor for changes in dimensionality to mark the arrival of injected fluids. We then present a method of inverting MT data for changes in impedance rather than for resistivity.

Modeling the effects of auxiliary gas injection and fuel injection rate shape on diesel engine combustion and emissions

NASA Astrophysics Data System (ADS)

Mather, Daniel Kelly

1998-11-01

The effect of auxiliary gas injection and fuel injection rate-shaping on diesel engine combustion and emissions was studied using KIVA a multidimensional computational fluid dynamics code. Auxiliary gas injection (AGI) is the injection of a gas, in addition to the fuel injection, directly into the combustion chamber of a diesel engine. The objective of AGI is to influence the diesel combustion via mixing to reduce emissions of pollutants (soot and NO x). In this study, the accuracy of modeling high speed gas jets on very coarse computational grids was addressed. KIVA was found to inaccurately resolve the jet flows near walls. The cause of this inaccuracy was traced to the RNG k - ɛ turbulence model with the law-of-the-wall boundary condition used by KIVA. By prescribing the lengthscale near the nozzle exit, excellent agreement between computed and theoretical jet penetration was attained for a transient gas jet into a quiescent chamber at various operating conditions. The effect of AGI on diesel engine combustion and emissions was studied by incorporating the coarse grid gas jet model into a detailed multidimensional simulation of a Caterpillar 3401 heavy-duty diesel engine. The effects of AGI timing, composition, amount, orientation, and location were investigated. The effects of AGI and split fuel injection were also investigated. AGI was found to be effective at reducing soot emissions by increasing mixing within the combustion chamber. AGI of inert gas was found to be effective at reducing emissions of NOx by depressing the peak combustion temperatures. Finally, comparison of AGI simulations with experiments were conducted for a TACOM-LABECO engine. The results showed that AGI improved soot oxidation throughout the engine cycle. Simulation of fuel injection rate-shaping investigated the effects of three injection velocity profiles typical of unit-injector type, high-pressure common-rail type, and accumulator-type fuel injectors in the Caterpillar 3401 heavy-duty diesel engine. Pollutant emissions for the engine operating with different injection velocity profiles reflected the sensitivity of diesel engines to the location of pollutants within the combustion chamber, as influenced by the fuel injection.

Spin injection devices with high mobility 2DEG channels (Conference Presentation)

NASA Astrophysics Data System (ADS)

Ciorga, Mariusz; Oltscher, Martin; Kuczmik, Thomas; Loher, Josef; Bayer, Andreas; Schuh, Dieter; Bougeard, Dominique; Weiss, Dieter

2016-10-01

Effective electrical spin injection into two-dimensional electron gas (2DEG) is a prerequisite for many new functionalities in spintronic device concepts, with the Datta-Das spin field effect transistor [1] being a primary example. Here we will discuss some of the results of our studies on spin injection devices with high mobility 2DEG confined in an inverted AlGaAs/GaAs heterojunction and a diluted ferromagnetic semiconductor (Ga,Mn)As employed as a source and a detector of spin-polarized carriers. Firstly we will show that nonlocal spin valve signal in such devices can significantly exceed the prediction of the standard model of spin injection based on spin drift-diffusion equations [2], what leads to conclusion that ballistic transport in the 2D region directly below the injector should be taken into account to fully describe the spin injection process [3]. Furthermore, we demonstrate also a large magnetoresistance (MR) signal of 20% measured in local configuration, i.e., with spin-polarized current flowing between two ferromagnetic contacts. To our knowledge, this is the highest value of MR observed so far in semiconductor channels. The work has been supported by Deutsche Forschungsgemeinschaft (DFG) through SFB689. [1] S. Datta and B. Das, Appl. Phys. Lett. 56, 665 (1990) [2] M. Oltscher et al., Phys. Rev. Lett. 113, 236602 (2014) [3] K. Cheng and S. Zhang, Phys. Rev. B 92, 214402 (2015)

Integrated hot-melt extrusion - injection molding continuous tablet manufacturing platform: Effects of critical process parameters and formulation attributes on product robustness and dimensional stability.

PubMed

Desai, Parind M; Hogan, Rachael C; Brancazio, David; Puri, Vibha; Jensen, Keith D; Chun, Jung-Hoon; Myerson, Allan S; Trout, Bernhardt L

2017-10-05

This study provides a framework for robust tablet development using an integrated hot-melt extrusion-injection molding (IM) continuous manufacturing platform. Griseofulvin, maltodextrin, xylitol and lactose were employed as drug, carrier, plasticizer and reinforcing agent respectively. A pre-blended drug-excipient mixture was fed from a loss-in-weight feeder to a twin-screw extruder. The extrudate was subsequently injected directly into the integrated IM unit and molded into tablets. Tablets were stored in different storage conditions up to 20 weeks to monitor physical stability and were evaluated by polarized light microscopy, DSC, SEM, XRD and dissolution analysis. Optimized injection pressure provided robust tablet formulations. Tablets manufactured at low and high injection pressures exhibited the flaws of sink marks and flashing respectively. Higher solidification temperature during IM process reduced the thermal induced residual stress and prevented chipping and cracking issues. Polarized light microscopy revealed a homogeneous dispersion of crystalline griseofulvin in an amorphous matrix. DSC underpinned the effect of high tablet residual moisture on maltodextrin-xylitol phase separation that resulted in dimensional instability. Tablets with low residual moisture demonstrated long term dimensional stability. This study serves as a model for IM tablet formulations for mechanistic understanding of critical process parameters and formulation attributes required for optimal product performance. Copyright © 2017 Elsevier B.V. All rights reserved.

Microbially Enhanced Oil Recovery by Sequential Injection of Light Hydrocarbon and Nitrate in Low- And High-Pressure Bioreactors.

PubMed

Gassara, Fatma; Suri, Navreet; Stanislav, Paul; Voordouw, Gerrit

2015-10-20

Microbially enhanced oil recovery (MEOR) often involves injection of aqueous molasses and nitrate to stimulate resident or introduced bacteria. Use of light oil components like toluene, as electron donor for nitrate-reducing bacteria (NRB), offers advantages but at 1-2 mM toluene is limiting in many heavy oils. Because addition of toluene to the oil increased reduction of nitrate by NRB, we propose an MEOR technology, in which water amended with light hydrocarbon below the solubility limit (5.6 mM for toluene) is injected to improve the nitrate reduction capacity of the oil along the water flow path, followed by injection of nitrate, other nutrients (e.g., phosphate) and a consortium of NRB, if necessary. Hydrocarbon- and nitrate-mediated MEOR was tested in low- and high-pressure, water-wet sandpack bioreactors with 0.5 pore volumes of residual oil in place (ROIP). Compared to control bioreactors, those with 11-12 mM of toluene in the oil (gained by direct addition or by aqueous injection) and 80 mM of nitrate in the aqueous phase produced 16.5 ± 4.4% of additional ROIP (N = 10). Because toluene is a cheap commodity chemical, HN-MEOR has the potential to be a cost-effective method for additional oil production even in the current low oil price environment.

A ferritin-containing nanoconjugate as MRI image-guidance to target Necl-5, a tumor-surface antigen: a potential thermal accelerant for microwave ablation

NASA Astrophysics Data System (ADS)

Park, William K. C.; Mills, David R.; Lim, Sierin; Sana, Barindra; Frank, Victoria E.; Kenyon, Brendan M.; Primmer, Michael P.; Paul, Jarod B.; Baird, Greyson L.; Walsh, Edward; Dupuy, Damian E.

2017-02-01

Purpose: A ferritin-containing nanoparticle conjugated with a target-specific antibody was investigated as a MRI contrast agent for tumor detection. A genetically modified ferritin to markedly improve Fe (III) payload (up to 7,000 Fe ions), was chemically tethered to a monoclonal antibody against rat Nectin-like molecule 5 (Necl-5). Necl-5 is a cell surface glycoprotein that is highly expressed on the cell surface of many common epithelial cancers, including prostate cancer. It was previously demonstrated that this novel nanoconjugate agent exhibited effective in vitro targeting of Necl- 5 expressing tumor cells and exhibited strong MRI contrast characteristics via shortening of T2. Here, we demonstrate that the nanoconjugate-Necl-5 interaction can be exploited to target and detect tumor in vivo by MRI. Procedure: Using an in vivo tumor model (i.e., tumor size 0.5-1 cm, immunodeficient beige/nude/xid mouse, xenograft injection with transformed rat prostate cells), efficacy of the conjugate targeting the tumor was examined. We used two injection strategies, a direct and a tail vein injection (0.8 mg, 300 μL per subject). Pre-injection baseline and postinjection scans were performed with the following spin-echo sequence parameters: Field of view = 90x53mm, reconstruction matrix size = 192x114, slice thickness = 1mm (10 slices), repetition time (TR) = 2070 ms, echo times (TE) = 11-198 ms in 11ms steps (18 echoes), number of averages = 2, acquisition time per scan = 7min 56s. Results: All T2 data obtained were converted to R2 for demonstration purposes (R2 = 1/T2). The tail vein injected conjugate significantly increased R2 response (22.9 +/- 5.2 s-1) as compared to control (13.5 +/-1.7 s-1) at 4 h. The weaker R2 increase was noted (15.2 +/- 2.0 s-1) at 24 h. No notable changes in R2 were observed in surrounding tissues regardless the stages of the measurement. We also measured the initial conjugate kinetics for both injection methods with respect to the ability of targeting the tumor. Direct injection of the nanoconjugate in to the center of the tumor showed a stronger and more rapid increase in R2 than the tail vein injection. Conclusion: The nanoconjugate interacts strongly and selectively in situ with Necl-5 overexpressing tumor cells. Direct injection of the nanoconjugate into the body of the tumor caused a more significant in situ R2 increase in MRI than the tail vein injection. Varying degrees of R2 increase within the tumor mass is likely to represent different distribution patterns of the conjugate, reflective of tumor heterogeneity.

Effects of 5,7-DHT Injection into the Optic Lobe on the Circadian Locomotor Rhythm in the Cricket, Gryllus bimaculatus.

PubMed

Germ, M; Tomioka, K

1998-06-01

The effect of direct 5,7-dihydroxytryptamine (5,7-DHT) injection into the medulla region of the optic lobe on the locomotor activity was investigated in the adult male cricket, Gryllus bimaculatus. After a 6 hr phase advance of a light-dark cycle, the 5,7-DHT injected animals needed significantly longer time for resynchronization to the new cycle (6.55 +/- 0.62 days) than the control, Ringer's solution injected animals (3.17 +/- 0.15 days; P < 0.001, t-test). Light induced a bout of activity (i.e., masking effect) when light-dark cycle was phase advanced by 6 hr and the duration of the masking effect was significantly longer in 5,7-DHT injected animals. An initial bout of the nocturnal activity was significantly greater in the 5,7-DHT injected animal. Under constant darkness, the freerunning periods of both groups were not significantly different. Under constant light, a significantly higher percentage of 5,7-DHT injected animals showed arrhythmicity compared with the control group. An analysis carried by high-pressure liquid chromatography with electro-chemical detection (HPLC-ECD) revealed that the serotonin content in the optic lobe was significantly reduced to less than 50% in the 5,7-DHT injected animals, even one month after the injection. These results suggest that serotonin plays important roles in the regulation of circadian locomotor rhythms of the cricket mainly by regulating the sensitivity of the photoreceptive system.

Flow visualization of discrete hole film cooling for gas turbine applications

NASA Technical Reports Server (NTRS)

Colladay, R. S.; Russell, L. M.

1975-01-01

Film injection from discrete holes in a three row staggered array with 5-diameter spacing is studied for three different hole angles: (1) normal, (2) slanted 30 deg to the surface in the direction of the mainstream, and (3) slanted 30 deg to the surface and 45 deg laterally to the mainstream. The boundary layer thickness-to-hole diameter ratio and Reynolds number are typical of gas turbine film cooling applications. Two different injection locations are studied to evaluate the effect of boundary layer thickness on film penetration and mixing. Detailed streaklines showing the turbulent motion of the injected air are obtained by photographing very small neutrally buoyant helium filled 'soap' bubbles which follow the flow field. Unlike smoke, which diffuses rapidly in the high turbulent mixing region associated with discrete hole blowing, the bubble streaklines passing downstream injection locations are clearly identifiable and can be traced back to their origin. Visualization of surface temperature patterns obtained from infrared photographs of a similar film cooled surface are also included.

Permanent magnet focused X-band photoinjector

DOEpatents

Yu, David U. L.; Rosenzweig, James

2002-09-10

A compact high energy photoelectron injector integrates the photocathode directly into a multicell linear accelerator with no drift space between the injection and the linac. High electron beam brightness is achieved by accelerating a tightly focused electron beam in an integrated, multi-cell, X-band rf linear accelerator (linac). The photoelectron linac employs a Plane-Wave-Transformer (PWT) design which provides strong cell-to-cell coupling, easing manufacturing tolerances and costs.

Hydraulic Fracture Induced Seismicity During A Multi-Stage Pad Completion in Western Canada: Evidence of Activation of Multiple, Parallel Faults

NASA Astrophysics Data System (ADS)

Maxwell, S.; Garrett, D.; Huang, J.; Usher, P.; Mamer, P.

2017-12-01

Following reports of injection induced seismicity in the Western Canadian Sedimentary Basin, regulators have imposed seismic monitoring and traffic light protocols for fracturing operations in specific areas. Here we describe a case study in one of these reservoirs, the Montney Shale in NE British Columbia, where induced seismicity was monitored with a local array during multi-stage hydraulic fracture stimulations on several wells from a single drilling pad. Seismicity primarily occurred during the injection time periods, and correlated with periods of high injection rates and wellhead pressures above fracturing pressures. Sequential hydraulic fracture stages were found to progressively activate several parallel, critically-stressed faults, as illuminated by multiple linear hypocenter patterns in the range between Mw 1 and 3. Moment tensor inversion of larger events indicated a double-couple mechanism consistent with the regional strike-slip stress state and the hypocenter lineations. The critically-stressed faults obliquely cross the well paths which were purposely drilled parallel to the minimum principal stress direction. Seismicity on specific faults started and stopped when fracture initiation points of individual injection stages were proximal to the intersection of the fault and well. The distance ranges when the seismicity occurs is consistent with expected hydraulic fracture dimensions, suggesting that the induced fault slip only occurs when a hydraulic fracture grows directly into the fault and the faults are temporarily exposed to significantly elevated fracture pressures during the injection. Some faults crossed multiple wells and the seismicity was found to restart during injection of proximal stages on adjacent wells, progressively expanding the seismogenic zone of the fault. Progressive fault slip is therefore inferred from the seismicity migrating further along the faults during successive injection stages. An accelerometer was also deployed close to the pad operations providing information about the local ground motion at near offsets, although no ground motion was recorded that exceeds the minimum levels requiring mandatory reporting to the regulator.

Influence of Compression Ratio on High Load Performance and Knock Behavior for Gasoline Port-Fuel Injection, Natural Gas Direct Injection and Blended Operation in a Spark Ignition Engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pamminger, Michael; Sevik, James; Scarcelli, Riccardo

Natural Gas (NG) is an alternative fuel which has attracted a lot of attention recently, in particular in the US due to shale gas availability. The higher hydrogen-to-carbon (H/C) ratio, compared to gasoline, allows for decreasing carbon dioxide emissions throughout the entire engine map. Furthermore, the high knock resistance of NG allows increasing the efficiency at high engine loads compared to fuels with lower knock resistance. NG direct injection (DI) allows for fuel to be added after intake valve closing (IVC) resulting in an increase in power density compared to an injection before IVC. Steady-state engine tests were performed onmore » a single-cylinder research engine equipped with gasoline (E10) port-fuel injection (PFI) and NG DI to allow for in-cylinder blending of both fuels. Knock investigations were performed at two discrete compression ratios (CR), 10.5 and 12.5. Operating conditions span mid-load, wide-open-throttle and boosted conditions, depending on the knock response of the fuel blend. Blended operation was performed using E10 gasoline and NG. An additional gasoline type fuel (E85) with higher knock resistance than E10 was used as a high-octane reference fuel, since the octane rating of E10-NG fuel blends is unknown. Spark timing was varied at different loads under stoichiometric conditions in order to study the knock response as well as the effects on performance and efficiency. As anticipated, results suggest that the knock resistance can be increased significantly by increasing the NG amount. Comparing the engine operation with the least knock resistant fuel, E10 PFI, and the fuel blend with the highest knock resistance, 75% NG DI, shows an increase in indicated mean effective pressure of about 9 bar at CR 12.5. The usage of reference fuels with known knock characteristics allowed an assessment of knock characteristic of intermediate E10-NG blend levels. Mathematical correlations were developed allowing characterizing the occurrence of knocking combustion by using the Livengood-Wu knock integral. For most of the fueling strategies and operating conditions, the mathematical correlations show good agreement when compared to experimental data.« less

Robotic planetary science missions enabled with small NTR engine/stage technologies

NASA Astrophysics Data System (ADS)

Borowski, Stanley K.

1995-10-01

The high specific impulse (Isp) and engine thrust-to-weight ratio of liquid hydrogen (LH2)-cooled nuclear thermal rocket (NTR) engines makes them ideal for upper stage applications to difficult robotic planetary science missions. A small 15 thousand pound force (klbf) NTR engine using a uranium-zirconium-niobium 'ternary carbide' fuel (Isp approximately 960 seconds at approximately 3025K) developed in the Commonwealth of Independent States (CIS) is examined and its use on an expendable injection stage is shown to provide major increases in payload delivered to the outer planets (Saturn, Uranus, Neptune and Pluto). Using a single 'Titan IV-class' launch vehicle, with a lift capability to low Earth orbit (LEO) of approximately 20 metric tons (t), an expendable NTR upper stage can inject two Pluto 'Fast Flyby' spacecraft (PFF/SC) plus support equipment-combined mass of approximately 508 kg--on high energy, '6.5-9.2 year' direct trajectory missions to Pluto. A conventional chemical propulsion mission would use a liquid oxygen (LOX)/LH2 'Centaur' upper stage and two solid rocket 'kick motors' to inject a single PFF/SC on the same Titan IV launch vehicle. For follow on Pluto missions, the NTR injection stage would utilize a Jupiter 'gravity assist' (JGA) maneuver to launch a LOX/liquid methane (CH4) capture stage (Isp approximately 375 seconds) and a Pluto 'orbiter' spacecraft weighing between approximately 167-312 kg. With chemical propulsion, a Pluto orbiter mission is not a viable option because c inadequate delivered mass. Using a 'standardized' NTR injection stage and the same single Titan IV launch scenario, 'direct flight' (no gravity assist) orbiter missions to Saturn, Uranus and Neptune are also enabled with transit times of 2.3, 6.6, and 12.6 years, respectively. Injected mass includes a storable, nitrogen tetroxide/monomethyl hydrazine (N2O4/MMH) capture stage (Isp approximately 330 seconds) and orbiter payloads 340 to 820% larger than that achievable using a LOX/LH2-fueled injection stage. The paper discusses NTR technology and mission characteristics, shows NTR stage and payload accommodations within the 26.2 m long Titan IV payload fairing, and discusses NTR stage performance as a function of assumed cryogenic tank technology.

Robotic Planetary Science Missions Enabled with Small NTR Engine/Stage Technologies

NASA Technical Reports Server (NTRS)

Borowski, Stanley K.

1995-01-01

The high specific impulse (Isp) and engine thrust-to-weight ratio of liquid hydrogen (LH2)-cooled nuclear thermal rocket (NTR) engines makes them ideal for upper stage applications to difficult robotic planetary science missions. A small 15 thousand pound force (klbf) NTR engine using a uranium-zirconium-niobium 'ternary carbide' fuel (Isp approximately 960 seconds at approximately 3025K) developed in the Commonwealth of Independent States (CIS) is examined and its use on an expendable injection stage is shown to provide major increases in payload delivered to the outer planets (Saturn, Uranus, Neptune and Pluto). Using a single 'Titan IV-class' launch vehicle, with a lift capability to low Earth orbit (LEO) of approximately 20 metric tons (t), an expendable NTR upper stage can inject two Pluto 'Fast Flyby' spacecraft (PFF/SC) plus support equipment-combined mass of approximately 508 kg--on high energy, '6.5-9.2 year' direct trajectory missions to Pluto. A conventional chemical propulsion mission would use a liquid oxygen (LOX)/LH2 'Centaur' upper stage and two solid rocket 'kick motors' to inject a single PFF/SC on the same Titan IV launch vehicle. For follow on Pluto missions, the NTR injection stage would utilize a Jupiter 'gravity assist' (JGA) maneuver to launch a LOX/liquid methane (CH4) capture stage (Isp approximately 375 seconds) and a Pluto 'orbiter' spacecraft weighing between approximately 167-312 kg. With chemical propulsion, a Pluto orbiter mission is not a viable option because c inadequate delivered mass. Using a 'standardized' NTR injection stage and the same single Titan IV launch scenario, 'direct flight' (no gravity assist) orbiter missions to Saturn, Uranus and Neptune are also enabled with transit times of 2.3, 6.6, and 12.6 years, respectively. Injected mass includes a storable, nitrogen tetroxide/monomethyl hydrazine (N2O4/MMH) capture stage (Isp approximately 330 seconds) and orbiter payloads 340 to 820% larger than that achievable using a LOX/LH2-fueled injection stage. The paper discusses NTR technology and mission characteristics, shows NTR stage and payload accommodations within the 26.2 m long Titan IV payload fairing, and discusses NTR stage performance as a function of assumed cryogenic tank technology.

Biosynthesis and secretion of catalytically active acetylcholinesterase in Xenopus oocytes microinjected with mRNA from rat brain and from Torpedo electric organ.

PubMed

Soreq, H; Parvari, R; Silman, I

1982-02-01

A novel technique was developed for monitoring the level of the mRNA species that direct the synthesis of acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7), using microinjected Xenopus oocytes as a translation system. When injected with poly(A)-containing RNA from whole rat brain or rat cerebellum and from electric organ of Torpedo ocellata, Xenopus oocytes synthesize and secrete catalytically active cholinesterase. The newly synthesized enzyme, which is mostly secreted into the oocytes incubation medium, appears to be primarily AcChoEase because it is inhibited by the specific inhibitor BW 284C51. The new enzymatic activity can be detected after injection of as little as 12.5 ng of poly(A)-containing RNA per oocyte, and there is a linear dependence of the oocytes' ability to form AcChoEase on the amount of injected RNA. The AcChoEase mRNA displays a tau 1/2 of about 10 +/- 3 hr in injected oocytes. The abundance of AcChoEase mRNA in the total nonfractionated mRNA injected was calculated to be ca. 1 x 10(-5), a value similar to the level of AcChoEase protein determined in rat brain. The combination of the high turnover number of AcChoEase, the efficiency of the oocyte system, and the sensitivity of the assay used thus permit the accurate monitoring of the scarce mRNA species that direct the synthesis of this enzyme.

Overview of MST Results and Plans

NASA Astrophysics Data System (ADS)

Sarff, J. S.

2008-11-01

Improved confinement with high beta has been established in MST over its full range of plasma current capability using transient inductive current profile control. Both thermal electron and ion confinement are increased, and energetic electrons are observed to 100 keV. The global energy confinement time is 12 ms at high current and high temperature (Te=2 keV, Ti =1 keV), with βtot=10% (only Ohmic heating). Maximum βtot=26% is attained at lower current and temperature with D2 pellet injection, without evidence of hard-beta-limit phenomena. Momentum transport associated with MHD tearing shows the fascinating behavior that the Maxwell and Reynolds turbulent stresses are both large but oppositely directed in sawtooth magnetic relaxation events. Momentum is transported rapidly in these events, presumably through the imbalance in the stresses. Electron temperature fluctuations associated with MHD tearing are measured using a multi-point, multi-pulse Thomson scattering diagnostic. A 5-250 kHz pulse-burst laser is under construction to extend the Thomson capability to high frequency. Lower hybrid and electron Bernstein wave injection are under development to provide more sustained current profile control and heating. X-ray emission from the plasma is observed for both waves at 175 kW injected power. Substantial new experimental capability will be provided by a recently installed programmable power supply for the toroidal field, a new 1 MW, 20 ms neutral beam injection system, and upgraded OFCD system. Supported by U.S. DoE and NSF.

Experimental Investigation of Fuel-Reactivity Controlled Compression Ignition (RCCI) Combustion Mode in a Multi-Cylinder, Light-Duty Diesel Engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, Kukwon; Curran, Scott; Prikhodko, Vitaly Y

2011-01-01

An experimental study was performed to provide the combustion and emission characteristics resulting from fuel-reactivity controlled compression ignition (RCCI) combustion mode utilizing dual-fuel approach in a light-duty, multi-cylinder diesel engine. In-cylinder fuel blending using port fuel injection of gasoline before intake valve opening (IVO) and early-cycle, direct injection of diesel fuel was used as the charge preparation and fuel blending strategy. In order to achieve the desired auto-ignition quality through the stratification of the fuel-air equivalence ratio ( ), blends of commercially available gasoline and diesel fuel were used. Engine experiments were performed at an engine speed of 2300rpm andmore » an engine load of 4.3bar brake mean effective pressure (BMEP). It was found that significant reduction in both nitrogen oxide (NOx) and particulate matter (PM) was realized successfully through the RCCI combustion mode even without applying exhaust gas recirculation (EGR). However, high carbon monoxide (CO) and hydrocarbon (HC) emissions were observed. The low combustion gas temperature during the expansion and exhaust processes seemed to be the dominant source of high CO emissions in the RCCI combustion mode. The high HC emissions during the RCCI combustion mode could be due to the increased combustion quenching layer thickness as well as the -stratification at the periphery of the combustion chamber. The slightly higher brake thermal efficiency (BTE) of the RCCI combustion mode was observed than the other combustion modes, such as the conventional diesel combustion (CDC) mode, and single-fuel, premixed charge compression ignition (PCCI) combustion mode. The parametric study of the RCCI combustion mode revealed that the combustion phasing and/or the peak cylinder pressure rise rate of the RCCI combustion mode could be controlled by several physical parameters premixed ratio (rp), intake swirl intensity, and start of injection (SOI) timing of directly injected fuel unlike other low temperature combustion (LTC) strategies.« less

Alternative Fuels DISI Engine Research ? Autoignition Metrics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoberg, Carl Magnus Goran; Vuilleumier, David

Improved engine efficiency is required to comply with future fuel economy standards. Alternative fuels have the potential to enable more efficient engines while addressing concerns about energy security. This project contributes to the science base needed by industry to develop highly efficient direct injection spark igniton (DISI) engines that also beneficially exploit the different properties of alternative fuels. Here, the emphasis is on quantifying autoignition behavior for a range of spark-ignited engine conditions, including directly injected boosted conditions. The efficiency of stoichiometrically operated spark ignition engines is often limited by fuel-oxidizer end-gas autoignition, which can result in engine knock. Amore » fuel’s knock resistance is assessed empirically by the Research Octane Number (RON) and Motor Octane Number (MON) tests. By clarifying how these two tests relate to the autoignition behavior of conventional and alternative fuel formulations, fuel design guidelines for enhanced engine efficiency can be developed.« less

Direct current injection and thermocapillary flow for purification of aligned arrays of single-walled carbon nanotubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Xu; Islam, Ahmad E.; Seabron, Eric

2015-04-07

Aligned arrays of semiconducting single-walled carbon nanotubes (s-SWNTs) represent ideal configurations for use of this class of material in high performance electronics. Development of means for removing the metallic SWNTs (m-SWNTs) in as-grown arrays represents an essential challenge. Here, we introduce a simple scheme that achieves this type of purification using direct, selective current injection through interdigitated electrodes into the m-SWNTs, to allow their complete removal using processes of thermocapillarity and dry etching. Experiments and numerical simulations establish the fundamental aspects that lead to selectivity in this process, thereby setting design rules for optimization. Single-step purification of arrays that includemore » thousands of SWNTs demonstrates the effectiveness and simplicity of the procedures. The result is a practical route to large-area aligned arrays of purely s-SWNTs with low-cost experimental setups.« less

Exciton-dominant electroluminescence from a diode of monolayer MoS{sub 2}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, Yu; Ye, Ziliang; Gharghi, Majid

2014-05-12

In two-dimensional monolayer MoS{sub 2}, excitons dominate the absorption and emission properties. However, the low electroluminescent efficiency and signal-to-noise ratio limit our understanding of the excitonic behavior of electroluminescence. Here, we study the microscopic origin of the electroluminescence from a diode of monolayer MoS{sub 2} fabricated on a heavily p-type doped silicon substrate. Direct and bound-exciton related recombination processes are identified from the electroluminescence. At a high electron-hole pair injection rate, Auger recombination of the exciton-exciton annihilation of the bound exciton emission is observed at room temperature. Moreover, the efficient electrical injection demonstrated here allows for the observation of amore » higher energy exciton peak of 2.255 eV in the monolayer MoS{sub 2} diode, attributed to the excited exciton state of a direct-exciton transition.« less

Focal plane infrared readout circuit with automatic background suppression

NASA Technical Reports Server (NTRS)

Pain, Bedabrata (Inventor); Yang, Guang (Inventor); Sun, Chao (Inventor); Shaw, Timothy J. (Inventor); Wrigley, Chris J. (Inventor)

2002-01-01

A circuit for reading out a signal from an infrared detector includes a current-mode background-signal subtracting circuit having a current memory which can be enabled to sample and store a dark level signal from the infrared detector during a calibration phase. The signal stored by the current memory is subtracted from a signal received from the infrared detector during an imaging phase. The circuit also includes a buffered direct injection input circuit and a differential voltage readout section. By performing most of the background signal estimation and subtraction in a current mode, a low gain can be provided by the buffered direct injection input circuit to keep the gain of the background signal relatively small, while a higher gain is provided by the differential voltage readout circuit. An array of such readout circuits can be used in an imager having an array of infrared detectors. The readout circuits can provide a high effective handling capacity.

Identification of polar volatile organic compounds in consumer products and common microenvironments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallace, L.A.; Nelson, W.C.; Pellizzari, E.

1991-03-01

Polar volatile organic compounds were identified in the headspace of 31 fragrance products such as perfumes, colognes and soaps. About 150 different chemicals were identified in a semiquantitative fashion, using two methods to analyze the headspace: direct injection into a gas chromatograph and collection by an evacuated canister, each followed by GC-MS analysis. The canister method displayed low recoveries for most of the 25 polar chemical standards tested. However, reconstructed ion chromatograms (RICs) from the canister showed good agreement with RICs from the direct injection method except for some high boiling point compounds. Canister samples collected in 15 microenvironments expectedmore » to contain the fragrance products tested (potpourri stores, fragrance sections of department stores, etc.) showed relatively low concentrations of most of these polar chemicals compared with certain common nonpolar chemicals. The results presented will be useful for models of personal exposure and indoor air quality.« less

Direct Method Transcription for a Human-Class Translunar Injection Trajectory Optimization

NASA Technical Reports Server (NTRS)

Witzberger, Kevin E.; Zeiler, Tom

2012-01-01

This paper presents a new trajectory optimization software package developed in the framework of a low-to-high fidelity 3 degrees-of-freedom (DOF)/6-DOF vehicle simulation program named Mission Analysis Simulation Tool in Fortran (MASTIF) and its application to a translunar trajectory optimization problem. The functionality of the developed optimization package is implemented as a new "mode" in generalized settings to make it applicable for a general trajectory optimization problem. In doing so, a direct optimization method using collocation is employed for solving the problem. Trajectory optimization problems in MASTIF are transcribed to a constrained nonlinear programming (NLP) problem and solved with SNOPT, a commercially available NLP solver. A detailed description of the optimization software developed is provided as well as the transcription specifics for the translunar injection (TLI) problem. The analysis includes a 3-DOF trajectory TLI optimization and a 3-DOF vehicle TLI simulation using closed-loop guidance.

A novel pretreatment method combining sealing technique with direct injection technique applied for improving biosafety.

PubMed

Wang, Xinyu; Gao, Jing-Lin; Du, Chaohui; An, Jing; Li, MengJiao; Ma, Haiyan; Zhang, Lina; Jiang, Ye

2017-01-01

People today have a stronger interest in the risk of biosafety in clinical bioanalysis. A safe, simple, effective method of preparation is needed urgently. To improve biosafety of clinical analysis, we used antiviral drugs of adefovir and tenofovir as model drugs and developed a safe pretreatment method combining sealing technique with direct injection technique. The inter- and intraday precision (RSD %) of the method were <4%, and the extraction recoveries ranged from 99.4 to 100.7%. Meanwhile, the results showed that standard solution could be used to prepare calibration curve instead of spiking plasma, acquiring more accuracy result. Compared with traditional methods, the novel method not only improved biosecurity of the pretreatment method significantly, but also achieved several advantages including higher precision, favorable sensitivity and satisfactory recovery. With these highly practical and desirable characteristics, the novel method may become a feasible platform in bioanalysis.

Intracranial hypotension headache caused by a massive cerebrospinal fluid leak successfully treated with a targeted c2 epidural blood patch: a case report.

PubMed

Sykes, Kenneth T; Yi, Xiaobin

2013-01-01

Cervical epidural steroid injections, administered either interlaminarly or transforaminally, are common injection therapies used in many interventional pain management practices to treat cervicalgia or cervicobrachial pain secondary to spondylosis or intervertebral disc displacement of the cervical spine. Among the risks associated with these procedures are the risk for inadvertent dural puncture and the development of positional headache from intracranial hypotension. We report the case of a 31-year-old woman with a history of migraine and cervicalgia from cervical spine spondylosis and cervical disc degenerative disease that developed an intractable orthostatic headache accompanied by nausea and vomiting after a therapeutic high cervical intralaminar epidural steroid injection was administered directly to the C1-C2 spinal level. Although the initial magnetic resonance imaging of the brain was unremarkable, a computed tomography myelogram study revealed a massive cerebrospinal fluid (CSF) leak from the cervical spine.  Repeated cervical epidural blood patches using a catheter targeted to the high cervical spine (C2) to inject 15 mL of autologous blood was required to totally alleviate her symptoms after she failed conservative therapy. Determining the optimal location or approach to administer an epidural blood patch can be a challenge depending on the location of the CSF leak. Our case demonstrates that targeted cervical epidural blood patch placement using an easily manipulated catheter under fluoroscopic guidance is a safe and effective approach to treat a massive CSF leak in the high cervical spine region caused by prior therapeutic cervical spine epidural steroid injection.

Speed of sound measurements and mixing characterization of underexpanded fuel jets with supercritical reservoir condition using laser-induced thermal acoustics

NASA Astrophysics Data System (ADS)

Baab, S.; Förster, F. J.; Lamanna, G.; Weigand, B.

2016-11-01

The four-wave mixing technique laser-induced thermal acoustics was used to measure the local speed of sound in the farfield zone of extremely underexpanded jets. N-hexane at supercritical injection temperature and pressure (supercritical reservoir condition) was injected into quiescent subcritical nitrogen (with respect to the injectant). The technique's capability to quantify the nonisothermal, turbulent mixing zone of small-scale jets is demonstrated for the first time. Consistent radially resolved speed of sound profiles are presented for different axial positions and varying injection temperatures. Furthermore, an adiabatic mixing model based on nonideal thermodynamic properties is presented to extract mixture composition and temperature from the experimental speed of sound data. High fuel mass fractions of up to 94 % are found for the centerline at an axial distance of 55 diameters from the nozzle followed by a rapid decay in axial direction. This is attributed to a supercritical fuel state at the nozzle exit resulting in the injection of a high-density fluid. The obtained concentration data are complemented by existing measurements and collapsed in a similarity law. It allows for mixture prediction of underexpanded jets with supercritical reservoir condition provided that nonideal thermodynamic behavior is considered for the nozzle flow. Specifically, it is shown that the fuel concentration in the farfield zone is very sensitive to the thermodynamic state at the nozzle exit. Here, a transition from supercritical fluid to subcritical vapor state results in strongly varying fuel concentrations, which implies high impact on the mixture formation and, consequently, on the combustion characteristics.

Fluidized bed injection assembly for coal gasification

DOEpatents

Cherish, Peter; Salvador, Louis A.

1981-01-01

A coaxial feed system for fluidized bed coal gasification processes including an inner tube for injecting particulate combustibles into a transport gas, an inner annulus about the inner tube for injecting an oxidizing gas, and an outer annulus about the inner annulus for transporting a fluidizing and cooling gas. The combustibles and oxidizing gas are discharged vertically upward directly into the combustion jet, and the fluidizing and cooling gas is discharged in a downward radial direction into the bed below the combustion jet.

Fuel-Air Injection Effects on Combustion in Cavity-Based Flameholders in a Supersonic Flow

DTIC Science & Technology

2005-03-01

both fuel and air provided additional capability to tune the cavity such that a more stable decentralized flame results. The addition of air...Mark Gruber of AFRL/PRAS and Mr. Mark Hsu of Innovative Scientific Solutions Inc. for both the support and latitude provided to me in this endeavor...addition of direct air injection to cavity combustion. Direct injection of both fuel and air provided additional capability to tune the cavity such that a

Some Factors Affecting Combustion in an Internal-Combustion Engine

NASA Technical Reports Server (NTRS)

Rothrock, A M; Cohn, Mildred

1936-01-01

An investigation of the combustion of gasoline, safety, and diesel fuels was made in the NACA combustion apparatus under conditions of temperature that permitted ignition by spark with direct fuel injection, in spite of the compression ratio of 12.7 employed. The influence of such variables as injection advance angle, jacket temperature, engine speed, and spark position was studied. The most pronounced effect was that an increase in the injection advance angle (beyond a certain minimum value) caused a decrease in the extent and rate of combustion. In almost all cases combustion improved with increased temperature. The results show that at low air temperatures the rates of combustion vary with the volatility of the fuel, but that at high temperatures this relationship does not exist and the rates depend to a greater extent on the chemical nature of the fuel.

Validated ¹H and 13C Nuclear Magnetic Resonance Methods for the Quantitative Determination of Glycerol in Drug Injections.

PubMed

Lu, Jiaxi; Wang, Pengli; Wang, Qiuying; Wang, Yanan; Jiang, Miaomiao

2018-05-15

In the current study, we employed high-resolution proton and carbon nuclear magnetic resonance spectroscopy (¹H and 13 C NMR) for quantitative analysis of glycerol in drug injections without any complex pre-treatment or derivatization on samples. The established methods were validated with good specificity, linearity, accuracy, precision, stability, and repeatability. Our results revealed that the contents of glycerol were convenient to calculate directly via the integration ratios of peak areas with an internal standard in ¹H NMR spectra, while the integration of peak heights were proper for 13 C NMR in combination with an external calibration of glycerol. The developed methods were both successfully applied in drug injections. Quantitative NMR methods showed an extensive prospect for glycerol determination in various liquid samples.

Red phosphorescent organic light-emitting diodes based on the simple structure.

PubMed

Seo, Ji Hyun; Lee, Seok Jae; Kim, Bo Young; Choi, Eun Young; Han, Wone Keun; Lee, Kum Hee; Yoon, Seung Soo; Kim, Young Kwan

2012-05-01

We demonstrated that the simple layered red phosphorescent organic light-emitting diodes (OLEDs) are possible to have high efficiency, low driving voltage, stable roll-off efficiency, and pure emission color without hole injection and transport layers. We fabricated the OLEDs with a structure of ITO/CBP doped with Ir(pq)2(acac)/BPhen/Liq/Al, where the doping concentration of red dopant, Ir(pq)2(acac), was varied from 4% to 20%. As a result, the quantum efficiencies of 13.4, 11.2, 16.7, 10.8 and 9.8% were observed in devices with doping concentrations of 4, 8, 12, 16 and 20%, respectively. Despite of absence of the hole injection and transport layers, these efficiencies are superior to efficiencies of device with hole transporting layer due to direct hole injection from anode to dopant in emission layer.

Miniaturized flow injection analysis system

DOEpatents

Folta, James A.

1997-01-01

A chemical analysis technique known as flow injection analysis, wherein small quantities of chemical reagents and sample are intermixed and reacted within a capillary flow system and the reaction products are detected optically, electrochemically, or by other means. A highly miniaturized version of a flow injection analysis system has been fabricated utilizing microfabrication techniques common to the microelectronics industry. The microflow system uses flow capillaries formed by etching microchannels in a silicon or glass wafer followed by bonding to another wafer, commercially available microvalves bonded directly to the microflow channels, and an optical absorption detector cell formed near the capillary outlet, with light being both delivered and collected with fiber optics. The microflow system is designed mainly for analysis of liquids and currently measures 38.times.25.times.3 mm, but can be designed for gas analysis and be substantially smaller in construction.

Accuracy of MRI-compatible contrast media injectors.

PubMed

Saake, M; Wuest, W; Becker, S; Uder, M; Janka, R

2014-03-01

To analyze the exactness of MRI-compatible contrast media (CM) injectors in an experimental setup and clinical use. Ejected fluid volumes and amounts of CM were quantified for single and double piston injections. The focus was on small volumes, as used in pediatric examination and test-bolus measurements. Samples were collected before and after clinical MRI scans and amounts of CM were measured. For single piston injections the volume differences were minimal (mean difference 0.01  ml). For double piston injections the volume of the first injection was decreased (mean 20.74  ml, target 21.00  ml, p < 0.01). After a position change of the Y-piece of the injection system, the amount of CM differed significantly from the target value (mean 1.23  mmol and 0.83  mmol at 1  ml/s flow rate, target 1.00  mmol, p < 0.01), independently of the wait time. The clinical samples confirmed these findings. The pistons of modern CM injectors work exactly. However, for small CM volumes the injected amount of CM can differ significantly from the target value in both directions. Influence factors are an incomplete elimination of air and exchange processes between the CM and saline chaser in the injection system. • In MRI examinations of children and test-bolus measurements, small amounts of CM are used. • The accuracy of single piston injections is high. • In double piston injections the injected amount of CM can differ significantly from the target value. © Georg Thieme Verlag KG Stuttgart · New York.

Push-through direct injection NMR: an optimized automation method applied to metabolomics

EPA Science Inventory

There is a pressing need to increase the throughput of NMR analysis in fields such as metabolomics and drug discovery. Direct injection (DI) NMR automation is recognized to have the potential to meet this need due to its suitability for integration with the 96-well plate format. ...

Injection locking of a low cost high power laser diode at 461 nm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pagett, C. J. H.; Moriya, P. H., E-mail: paulohisao@ifsc.usp.br; Celistrino Teixeira, R.

2016-05-15

Stable laser sources at 461 nm are important for optical cooling of strontium atoms. In most existing experiments, this wavelength is obtained by frequency doubling infrared lasers, since blue laser diodes either have low power or large emission bandwidths. Here, we show that injecting less than 10 mW of monomode laser radiation into a blue multimode 500 mW high power laser diode is capable of slaving at least 50% of the power to the desired frequency. We verify the emission bandwidth reduction by saturation spectroscopy on a strontium gas cell and by direct beating of the slave with the mastermore » laser. We also demonstrate that the laser can efficiently be used within the Zeeman slower for optical cooling of a strontium atomic beam.« less

Performance comparison of supersonic ejectors with different motive gas injection schemes applicable for flowing medium gas laser

NASA Astrophysics Data System (ADS)

Singhal, G.; Subbarao, P. M. V.; Mainuddin; Tyagi, R. K.; Dawar, A. L.

2017-05-01

A class of flowing medium gas lasers with low generator pressures employ supersonic flows with low cavity pressure and are primarily categorized as high throughput systems capable of being scaled up to MW class. These include; Chemical Oxygen Iodine Laser (COIL) and Hydrogen (Deuterium) Fluoride (HF/DF). The practicability of such laser systems for various applications is enhanced by exhausting the effluents directly to ambient atmosphere. Consequently, ejector based pressure recovery forms a potent configuration for open cycle operation. Conventionally these gas laser systems require at least two ejector stages with low pressure stage being more critical, since it directly entrains the laser media, and the ensuing perturbation of cavity flow, if any, may affect laser operation. Hence, the choice of plausible motive gas injection schemes viz., peripheral or central is a fluid dynamic issue of interest, and a parametric experimental performance comparison would be beneficial. Thus, the focus is to experimentally characterize the effect of variation in motive gas supply pressure, entrainment ratio, back pressure conditions, nozzle injection position operated together with a COIL device and discern the reasons for the behavior.

The role of MHD in 3D aspects of massive gas injection

DOE PAGES

Izzo, Valerie A.; Parks, P. B.; Eidietis, Nicholas W.; ...

2015-06-26

Simulations of massive gas injection (MGI) for disruption mitigation in DIII-D are carried out to compare the toroidal peaking of radiated power for the cases of one and two gas jets. The radiation toroidal peaking factor (TPF) results from a combination of the distribution of impurities and the distribution of heat flux associated with then =1 mode. The injected impurities are found to spread helically along field lines preferentially toward the high-field-side, which is explained in terms of a nozzle equation. In light of this mechanism, reversing the current direction also reverses the toroidal direction of impurity spreading. During themore » pre-thermal quench phase of the disruption, the toroidal peaking of radiated power is reduced in the straightforward manner by increasing from one to two gas jets. However, during the thermal quench phase, reduction in the TPF is achieved only for a particular arrangement of the two gas valves with respect to the field line pitch. In particular, the relationship between the two valve locations and the 1/1 mode phase is critical, where gas valve spacing that is coherent with 1/1 symmetry effectively reduces TPF.« less

Sonographically guided deep plantar fascia injections: where does the injectate go?

PubMed

Maida, Eugene; Presley, James C; Murthy, Naveen; Pawlina, Wojciech; Smith, Jay

2013-08-01

To determine the distribution of sonographically guided deep plantar fascia injections in an unembalmed cadaveric model. A single experienced operator completed 10 sonographically guided deep plantar fascia injections in 10 unembalmed cadaveric specimens (5 right and 5 left) obtained from 6 donors (2 male and 4 female) aged 49 to 95 years (mean, 77.5 years) with a mean body mass index of 23.2 kg/m(2) (range, 18.4-26.3 kg/m(2)). A 12-3-MHz linear array transducer was used to direct a 22-gauge, 38-mm stainless steel needle deep to the plantar fascia at the anterior aspect of the calcaneus using an in-plane, medial-to-lateral approach. In each case, 1.5 mL of 50% diluted colored latex was injected deep to the plantar fascia. After a minimum of 72 hours, study coinvestigators dissected each specimen to assess injectate placement. All 10 injections accurately placed latex adjacent to the deep side of the plantar fascia at the anterior calcaneus. However, the flexor digitorum brevis (FDB) origin from the plantar fascia variably limited direct latex contact with the plantar fascia, and small amounts of latex interdigitated with the FDB origin in 90% (9 of 10). In all 10 specimens, latex also covered the traversing first branch of the lateral plantar nerve (FBLPN, ie, Baxter nerve) between the FDB and quadratus plantae muscles. No latex was found in the plantar fat pad or plantar fascia in any specimen. Sonographically guided deep plantar fascia injections reliably deliver latex deep to the plantar fascia while avoiding intrafascial injection. However, the extent of direct plantar fascia contact is variable due to the intervening FDB. On the contrary, the traversing FBLPN is reliably covered by the injection. Deep plantar fascia injections may have a role in the management of refractory plantar fasciitis, particularly following failed superficial perifascial or intrafascial injections, in cases of preferential deep plantar fascia involvement, or when entrapment/irritation of the distal FBLPN is suspected.

The 2014 Weld County, Colorado, Earthquakes: A developing case of induced seismicity?

NASA Astrophysics Data System (ADS)

Yeck, W. L.; Sheehan, A. F.; Weingarten, M.; Nakai, J.

2014-12-01

On June 1st 2014 (UTC), a M 3.2 earthquake occurred in Weld County, Colorado. Weld County is largely aseismic and this event was unexpected. There were no events in the ANSS Comprehensive Catalogue within 50 km of the earthquake. Weld County is the center of active oil and gas development, including many high-volume Class II wastewater injection wells. Injection wells have been linked to an increasing number of earthquakes throughout the US in recent years. Due to the lack of background seismicity in the area and the proximity of the earthquake to several injection wells, the University of Colorado requested seismometers from IRIS PASSCAL's Rapid Array Mobilization Program in order to study further seismicity. Seismic stations were deployed within 3 days of the June 1st event. We report on our ongoing findings from this deployment. To date, we have located 89 earthquakes and have detected over 600. These numbers continue to grow as we collect and analyze further data. Earthquake magnitudes remain small with only three earthquakes above M 2.0 recorded by our network, the largest of which was an M 2.6 earthquake on June 23rd 2014. Earthquakes locate in a small cluster (~2 km radius) centered near a high-volume injection well. This well operated at injection rates greater than 300,000 barrels/month since August 2013 and injects at a depth near the sediment-basement contact. Prior to our local deployment, the closest seismic station to the June 1st event was > 100 km away and therefore the evolution of seismicity prior the June 1st earthquake is poorly constrained. In order to better understand the temporal evolution of seismicity, we use match-filtering on data from these distant stations and find the earliest matching event on November 11th 2013. Due to the strong spatial and temporal correlation between these events and injection operations, we find it likely that these earthquakes are induced. In response to the ongoing seismicity near the well, the Colorado Oil and Gas Conservation Commission (COGCC) ordered the high-volume well shutdown for 20 days. The well has since restarted injection at lower rates, with the potential to increase injection rates over time. The shutdown and resumption of smaller injection volumes provides the unique opportunity to directly evaluate the seismicity's relationship to well operations.

Optical Injection Locking of Vertical Cavity Surface-Emitting Lasers: Digital and Analog Applications

NASA Astrophysics Data System (ADS)

Parekh, Devang

With the rise of mobile (cellphones, tablets, notebooks, etc.) and broadband wireline communications (Fiber to the Home), there are increasing demands being placed on transmitters for moving data from device to device and around the world. Digital and analog fiber-optic communications have been the key technology to meet this challenge, ushering in ubiquitous Internet and cable TV over the past 20 years. At the physical layer, high-volume low-cost manufacturing of semiconductor optoelectronic devices has played an integral role in allowing for deployment of high-speed communication links. In particular, vertical cavity surface emitting lasers (VCSEL) have revolutionized short reach communications and are poised to enter more markets due to their low cost, small size, and performance. However, VCSELs have disadvantages such as limited modulation performance and large frequency chirp which limits fiber transmission speed and distance, key parameters for many fiber-optic communication systems. Optical injection locking is one method to overcome these limitations without re-engineering the VCSEL at the device level. By locking the frequency and phase of the VCSEL by the direct injection of light from another laser oscillator, improved device performance is achieved in a post-fabrication method. In this dissertation, optical injection locking of VCSELs is investigated from an applications perspective. Optical injection locking of VCSELs can be used as a pathway to reduce complexity, cost, and size of both digital and analog fiber-optic communications. On the digital front, reduction of frequency chirp via bit pattern inversion for large-signal modulation is experimentally demonstrated showing up to 10 times reduction in frequency chirp and over 90 times increase in fiber transmission distance. Based on these results, a new reflection-based interferometric model for optical injection locking was established to explain this phenomenon. On the analog side, the resonance frequency enhancement was exploited for millimeter-wave radio over fiber communications. Experimental demonstration of 4 Gb/s data transmission over 20 km of fiber and 3 m of wireless transmission at a 60 GHz carrier frequency was achieved. Additionally, optical injection of multi-transverse mode (MM) VCSELs was investigated showing record resonance frequency enhancement of > 54 GHz and 3-dB bandwidth of 38 GHz. Besides these applications, a number of other intriguing applications are also discussed, including an optoelectronic oscillator (OEO) and wavelength-division multiplexed passive optical networks (WDM-PON). Finally, the future of optical injection locking and its direction going forward will be discussed.

Determination of highly protein bound drugs in plasma using high-performance liquid chromatography and column switching, exemplified by the retinoids.

PubMed

Wyss, R; Bucheli, F

1988-12-02

During method development for the determination of either isotretinoin, tretinoin and their 4-oxo-metabolites, or etretinate, acitretin and 13-cis-acitretin in plasma using high-performance liquid chromatography and column switching, recovery problems arose, when undiluted plasma samples were injected directly onto the precolumn. These recovery problems may be due to the strong binding of the retinoids to different plasma proteins. Measures to overcome this strong protein binding, such as variation of the injection solution composition and the purge mobile phase, were systematically investigated. Best recoveries were obtained by diluting of plasma with 9 mM sodium hydroxide-acetonitrile (8:2, v/v) and protein precipitation with ethanol for the isotretinoin and etretinate series, respectively, in combination with the use of a purge mobile phase containing ammonium acetate and 10-20% acetonitrile. Less effective was the use of a longer precolumn or heating of the precolumn.

Simulation of Orientation in Injection Molding of High Aspect Ratio Particle Thermoplastic Composites

NASA Astrophysics Data System (ADS)

Vélez-García, Gregorio M.; Ortman, Kevin C.; Eberle, Aaron P. R.; Wapperom, Peter; Baird, Donald G.

2008-07-01

A 2D coupled Hele-Shaw flow approximation for predicting the flow-induced orientation of high aspect ratio particles in injection molded composite parts is presented. For a highly concentrated short glass fiber PBT suspension, the impact of inter-particle interactions and the orientation at the gate is investigated for a center-gated disk using material parameters determined from rheometry. Experimental orientation is determined from confocal laser micrographs using the methods of ellipses. The constitutive equations are discretized using discontinuous Galerkin Finite Elements. Model predictions are significantly improved by using a localized orientation measured experimentally at the gate region instead of random or averaged gapwise measured orientation assumed in previous studies. The predicted profile in different radial positions can be related to the layered structure along the gapwise direction. Model modifications including interactions have lower impact than the initial conditions.

Simple and rapid analysis of endocrine disruptors in liquid medicines and intravenous injection solutions by automated in-tube solid-phase microextraction/high performance liquid chromatography.

PubMed

Mitani, Kurie; Narimatsu, Shizuo; Izushi, Fumio; Kataoka, Hiroyuki

2003-07-14

A simple and rapid method was developed for analyzing contamination of endocrine disruptors in liquid medicines and intravenous injection solutions. Endocrine disrupting compounds such as bisphenol A (BPA), alkylphenols and phthalates were quantitated by on-line in-tube solid-phase microextraction coupled with high performance liquid chromatography (in-tube SPME/HPLC) with UV detection. The liquid medicines and intravenous injection solutions could be used directly without any pretreatment, and the BPA, alkylphenols and phthalates in these solutions were automatically analyzed. The limits of quantification for these compounds were 1-10 ng/ml. Recoveries of these compounds spiked to the intravenous injection solutions was over 80%, except for some phthalates. Di-n-butyl phthalate (DBP) was detected at a concentration of 7-60 ng/ml in most intravenous injection solutions in plastic containers, but it was not detected in solutions in glass bottles. Diethyl phthalate, di-n-propyl phthalate, DBP and di-2-ethylhexyl phthalate (DEHP) were also detected in syrup, lotion and eye drops in plastic containers. On the other hand, BPA and alkylphenols were not detected at all in these solutions. DEHP contamination from an administration set increased when total vitamin formulation was added to the infusion solution. DEHP was easily leached from polyvinyl chloride tubing by polysorbate 80. The in-tube SPME/HPLC method is simple, rapid and automatic, and it provides a useful tool for the screening and determination of endocrine disruptor contamination in liquid medicines and intravenous injection solutions.

Two-phase non-Newtonian hydrodynamic modeling of slurries

NASA Astrophysics Data System (ADS)

Wang, C. S.; Lyczkowski, R. W.; Berry, G. F.

The two-phase hydrodynamic theory of fluid/solid flow has been extended to incorporate the constitutive relationship for power-law non-Newtonian behavior. A model has been developed to predict the spatial and temporal variations in solids and liquid velocities and concentration of non-Newtonian slurries under high shear rates in diesel engine injection systems. Comparisons between the present non-Newtonian two-phase theory and the conventional theory have also been made. Selected results for diesel injection nozzle applications are presented. The results from this model can be used to calculate directly the erosion rates at the nozzle boundaries and the solids loading at the nozzle exit.

Oxidation of coal-water slurry feed to hydrogasifier

DOEpatents

Lee, Bernard S.

1976-01-01

An aqueous coal slurry is preheated, subjected to partial oxidation and vaporization by injection of high pressure oxygen and is introduced into a top section of a hydrogasifier in direct contact with hot methane-containing effluent gases where vaporization of the slurry is completed. The resulting solids are reacted in the hydrogasifier and the combined gases and vapors are withdrawn and subjected to purification and methanation to provide pipeline gas. The amount of oxygen injected into the slurry is controlled to provide the proper thermal balance whereby all of the water in the slurry can be evaporated in contact with the hot effluent gases from the hydrogasifier.

Superconductor fiber elongation with a heated injected gas

DOEpatents

Zeigler, D.D.; Conrad, B.L.; Gleixner, R.A.

1998-06-02

An improved method and apparatus for producing flexible fibers of superconducting material includes a crucible for containing a charge of the superconducting material. The material is melted in the crucible and falls in a stream through a bottom hole in the crucible. The stream falls through a protecting collar which maintains the stream at high temperatures. The stream is then supplied through a downwardly directed nozzle where it is subjected to a high velocity of a heated gas which breaks the melted superconducting material into ligaments which solidify into the flexible fibers. The fibers are collected by directing them against a collection filter. 10 figs.

Parametric investigation of secondary injection in post-chamber on combustion performance for hybrid rocket motor

NASA Astrophysics Data System (ADS)

Cai, Guobiao; Cao, Binbin; Zhu, Hao; Tian, Hui; Ma, Xuan

2017-11-01

The objective of this effort is to study the combustion performance of a hybrid rocket motor with the help of 3D steady-state numerical simulation, which applies 90% hydrogen peroxide as the oxidizer and hydroxyl-terminated polybutadiene as the fuel. A method of secondary oxidizer injection in post-chamber is introduced to investigate the flow field characteristics and combustion efficiency. The secondary injection medium is the mixed gas coming from liquid hydrogen peroxide catalytic decomposition. The secondary injectors are uniformly set along the circumferential direction of the post-chamber. The simulation results obtained by above model are verified by experimental data. Three influencing parameters are considered: secondary injection diameter, secondary injection angle and secondary injection numbers. Simulation results reveals that this design could improve the combustion efficiency with respect to the same motor without secondary injection. Besides, the secondary injection almost has no effect on the regression rate and fuel sueface temperature distribution. It is also presented that the oxidizer is injected by 8 secondary injectors with a diameter of 7-8 mm in the direction of 120°in post-chamber is identified as the optimized secondary injection pattern, through which combustion efficiency, specific impulse efficiency as well as utilization of propellants are all improved obviously.

Smart Application of Direct Gas Injection using a new conceptual model on Coherent and Incoherent Flow: From Bench Scale to Field Scale.

NASA Astrophysics Data System (ADS)

Geistlinger, H.; Samani, S.; Pohlert, M.; Martienssen, M.; Engelmann, F.; Hüttmann, S.

2008-12-01

Within the framework of the OXYWALL field experiment we developed the direct gas injection (DGI) of oxygen as a remediation technology, which allows the cost-efficient and large-scale cleaning of groundwater contaminated with organic contaminants. That technology can be used as wide-banded, unselective remediation method for complex contaminant mixtures. Particularly, it could be proofed in field experiments that mineral oil hydrocarbons, aromatic hydrocarbons (BTEX), the rather persistent gasoline component Methyl tertiary-butyl ether (MTBE), and chlorinated aliphatic and aromatic hydrocarbons, like Trichloroethene and Monochlorobenzene, can be aerobically metabolized by autochthon microorganisms. Over the last 8 years the field site was investigated and a dense monitoring network was installed using Geoprobe direct- push technology and standard hydrogeological investigations were conducted, like EC-Logs, Injections-Logs, Gamma-Logs, TDR-probes, oxygen measurements with in-situ optodes, and tracer test with test gases SF6, Ar, and Oxygen. The key parameter for controling and regulating the DGI is the spatial and temporal distribution of the gas phase. High-resolution optical bench scale experiments were conducted in order to investigate local gas flow pattern and integral flow properties caused by point-like gas injection into water-saturated glass beads and natural sands. We observed a grain-size (dk)- and flow-rate (Q) dependent transition from incoherent to coherent flow. Conceptualizing the stationary tortuous gas flow as core-annulus flow and applying Hagen- Poiseuille flow for a straight capillary, we propose a flow-rate- and grain-size dependent stability criterion that could describe our experimental results and was used for classifying the experiments in a dk-Q-diagram (flow chart). Since DGI simulations are mainly based on continuum models, we also test the validity of the continuum approach for two-fluid flow in macroscopic homogeneous media by comparing our experimental flow pattern with the theoretical ones. It was found that a pulse-like function yields the best fit for the lateral gas saturation profile. This strange behaviour of a relatively sharp saturation transition is in contradiction to the widely anticipated picture of a smooth Gaussian-like transition, which is obtained by the continuum approach. Based on lab experiments, the proposed flow chart, and computer simulations the DGI-technology will be advanced and optimized at the field scale. A proper application of continuum models to direct gas injection should check, whether stable coherent flow is achieved; estimate the coherence length, and account for the channelized flow pattern by a realistic capillary pressure - saturation relationship. Further research is needed for modeling of direct gas injection to include appropriate stability criteria, the transition from coherent to incoherent flow, and bubble trapping. Geistlinger, H., Krauss, G., Lazik, D., and Luckner, L. (2006) Direct gas injection into saturated glass beads: transition from incoherent to coherent gas flow pattern. Water Resour. Res., 42 (7) W07403. Lazik, D., G. Krauss, H. Geistlinger, and H.-J. Vogel (2008) Multi-scale optical analyses of dynamic gas saturation during air sparging into glass beads, Transp. Porous Media. 74, 87-104.

Numerical investigation of improving the performance of a single expansion ramp nozzle at off-design conditions by secondary injection

NASA Astrophysics Data System (ADS)

Lv, Zheng; Xu, Jinglei; Mo, Jianwei

2017-04-01

The performance of a single expansion ramp nozzle (SERN) is poor due to over-expansion at off-design conditions. The present study focuses on improving the SERN performance by secondary injection on the cowl and is carried out by using the k - ε RNG turbulence model. The incidence shock wave resulting from the secondary injection impinges on the expansion ramp, resulting in separation and the increase of the pressure distribution along the ramp. The performance of the SERN can be improved significantly, and the augmentation of the thrust coefficient, lift and pitch moment can be as high as 3.16%, 29.43% and 41.67%, respectively, when the nozzle pressure ratio (NPR) is 10. The location of the injection has a considerable effect on the lift and pitching moment, and the direction of the pitch moment can be changed from nose-up to nose-down when the injection is on the tail of the cowl. The effect of the injection on the axial thrust coefficient is much more apparent, if the operation NPR is far from the design point, and however, the results for the lift and pitching moment are opposite. The increases of injection total pressure and injection width have positive impacts on the SERN performance. And if the parameter φ maintains constant, the axial thrust coefficient would increase when the injection total pressure decreases, so low energy flow can also be used as the secondary injection without decreasing the lift and pitching moment. The mass flow rate of the injection can be decreased by applying the higher total temperature flow without reducing the performance of the SERN.

40 CFR 148.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS General § 148.2 Definitions. Injection interval means that part of the injection zone in which the well is screened, or in which the waste is otherwise directly emplaced...

Supercritical-fluid extraction and chromatography-mass spectrometry for analysis of mycotoxins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, R.D.; Udseth, H.R.

1982-07-01

The use of direct supercritical-fluid injection-mass spectrometry for the rapid analysis of mycotoxins of the tricothecene group is demonstrated. A solution containing diacetoxyscirpenol or T-2 toxin is injected into a fluid consisting primarily of pentane or carbon dioxide and is rapidly brought to supercritical conditions. Direct injection of the fluid stream into a chemical ionization source allows thermally labile compounds to be analyzed. Under these conditions trichothecene mass spectra showing significant (M + 1)/sup +/ ions and distinctive fragmentation patterns are obtained. Detection limits are in the subnanogram range. Direct analysis from complex substrates using selective supercritical-fluid extraction is proposed.more » 4 figures.« less

Computational study of interfacial charge transfer complexes of 2-anthroic acid adsorbed on a titania nanocluster for direct injection solar cells

NASA Astrophysics Data System (ADS)

Manzhos, Sergei; Kotsis, Konstantinos

2016-09-01

Adsorption and light absorption properties of interfacial charge transfer complexes of 2-anthroic acid and titania, promising for direct-injection solar cells, are studied ab initio. The formation of interfacial charge transfer bands is observed. The intensity of visible absorption is relatively low, highlighting a key challenge facing direct injection cells. We show that the popular strategy of using a lower level of theory for geometry optimization followed by single point calculations of adsorption or optical properties introduces significant errors which have been underappreciated: by up to 3 eV in adsorption energies, by up to 5 times in light absorption intensity.

Rapid engine test to measure injector fouling in diesel engines using vegetable oil fuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korus, R.A.; Jaiduk, J.; Peterson, C.L.

1985-11-01

Short engine tests were used to determine the rate of carbon deposition on direct injection diesel nozzles. Winter rape, high-oleic and high-linoleic safflower blends with 50% diesel were tested for carbon deposit and compared to that with D-2 Diesel Control Fuel. Deposits were greatest with the most unsaturated fuel, high-linoleic safflower, and least with winter rape. All vegetable oil blends developed power similar to diesel fueled engines with a 6 to 8% greater fuel consumption. 8 references.

Post-injection Multiphase Flow Modeling and Risk Assessments for Subsurface CO2 Storage in Naturally Fractured Reservoirs

NASA Astrophysics Data System (ADS)

Jin, G.

2015-12-01

Subsurface storage of carbon dioxide in geological formations is widely regarded as a promising tool for reducing global atmospheric CO2 emissions. Successful geologic storage for sequestrated carbon dioxides must prove to be safe by means of risk assessments including post-injection analysis of injected CO2 plumes. Because fractured reservoirs exhibit a higher degree of heterogeneity, it is imperative to conduct such simulation studies in order to reliably predict the geometric evolution of plumes and risk assessment of post CO2injection. The research has addressed the pressure footprint of CO2 plumes through the development of new techniques which combine discrete fracture network and stochastic continuum modeling of multiphase flow in fractured geologic formations. A subsequent permeability tensor map in 3-D, derived from our preciously developed method, can accurately describe the heterogeneity of fracture reservoirs. A comprehensive workflow integrating the fracture permeability characterization and multiphase flow modeling has been developed to simulate the CO2plume migration and risk assessments. A simulated fractured reservoir model based on high-priority geological carbon sinks in central Alabama has been employed for preliminary study. Discrete fracture networks were generated with an NE-oriented regional fracture set and orthogonal NW-fractures. Fracture permeability characterization revealed high permeability heterogeneity with an order of magnitude of up to three. A multiphase flow model composed of supercritical CO2 and saline water was then applied to predict CO2 plume volume, geometry, pressure footprint, and containment during and post injection. Injection simulation reveals significant permeability anisotropy that favors development of northeast-elongate CO2 plumes, which are aligned with systematic fractures. The diffusive spreading front of the CO2 plume shows strong viscous fingering effects. Post-injection simulation indicates significant upward lateral spreading of CO2 resulting in accumulation of CO2 directly under the seal unit because of its buoyancy and strata-bound vertical fractures. Risk assessment shows that lateral movement of CO2 along interconnected fractures requires widespread seals with high integrity to confine the injected CO2.

Structure of a bacterial virus DNA-injection protein complex reveals a decameric assembly with a constricted molecular channel

DOE PAGES

Zhao, Haiyan; Speir, Jeffrey A.; Matsui, Tsutomu; ...

2016-02-16

The multi-layered cell envelope structure of Gram-negative bacteria represents significant physical and chemical barriers for short-tailed phages to inject phage DNA into the host cytoplasm. Here we show that a DNA-injection protein of bacteriophage Sf6, gp12, forms a 465-kDa, decameric assembly in vitro. The electron microscopic structure of the gp12 assembly shows a ~150-Å, mushroom-like architecture consisting of a crown domain and a tube-like domain, which embraces a 25-Å-wide channel that could precisely accommodate dsDNA. The constricted channel suggests that gp12 mediates rapid, uni-directional injection of phage DNA into host cells by providing a molecular conduit for DNA translocation. Themore » assembly exhibits a 10-fold symmetry, which may be a common feature among DNA-injection proteins of P22-like phages and may suggest a symmetry mismatch with respect to the 6-fold symmetric phage tail. As a result, the gp12 monomer is highly flexible in solution, supporting a mechanism for translocation of the protein through the conduit of the phage tail toward the host cell envelope, where it assembles into a DNA-injection device.« less

Structure of a bacterial virus DNA-injection protein complex reveals a decameric assembly with a constricted molecular channel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Haiyan; Speir, Jeffrey A.; Matsui, Tsutomu

The multi-layered cell envelope structure of Gram-negative bacteria represents significant physical and chemical barriers for short-tailed phages to inject phage DNA into the host cytoplasm. Here we show that a DNA-injection protein of bacteriophage Sf6, gp12, forms a 465-kDa, decameric assembly in vitro. The electron microscopic structure of the gp12 assembly shows a ~150-Å, mushroom-like architecture consisting of a crown domain and a tube-like domain, which embraces a 25-Å-wide channel that could precisely accommodate dsDNA. The constricted channel suggests that gp12 mediates rapid, uni-directional injection of phage DNA into host cells by providing a molecular conduit for DNA translocation. Themore » assembly exhibits a 10-fold symmetry, which may be a common feature among DNA-injection proteins of P22-like phages and may suggest a symmetry mismatch with respect to the 6-fold symmetric phage tail. As a result, the gp12 monomer is highly flexible in solution, supporting a mechanism for translocation of the protein through the conduit of the phage tail toward the host cell envelope, where it assembles into a DNA-injection device.« less

Modeling of fault activation and seismicity by injection directly into a fault zone associated with hydraulic fracturing of shale-gas reservoirs

EPA Pesticide Factsheets

LBNL, in consultation with the EPA, expanded upon a previous study by injecting directly into a 3D representation of a hypothetical fault zone located in the geologic units between the shale-gas reservoir and the drinking water aquifer.

Determination of dasatinib in the tablet dosage form by ultra high performance liquid chromatography, capillary zone electrophoresis, and sequential injection analysis.

PubMed

Gonzalez, Aroa Garcia; Taraba, Lukáš; Hraníček, Jakub; Kozlík, Petr; Coufal, Pavel

2017-01-01

Dasatinib is a novel oral prescription drug proposed for treating adult patients with chronic myeloid leukemia. Three analytical methods, namely ultra high performance liquid chromatography, capillary zone electrophoresis, and sequential injection analysis, were developed, validated, and compared for determination of the drug in the tablet dosage form. The total analysis time of optimized ultra high performance liquid chromatography and capillary zone electrophoresis methods was 2.0 and 2.2 min, respectively. Direct ultraviolet detection with detection wavelength of 322 nm was employed in both cases. The optimized sequential injection analysis method was based on spectrophotometric detection of dasatinib after a simple colorimetric reaction with folin ciocalteau reagent forming a blue-colored complex with an absorbance maximum at 745 nm. The total analysis time was 2.5 min. The ultra high performance liquid chromatography method provided the lowest detection and quantitation limits and the most precise and accurate results. All three newly developed methods were demonstrated to be specific, linear, sensitive, precise, and accurate, providing results satisfactorily meeting the requirements of the pharmaceutical industry, and can be employed for the routine determination of the active pharmaceutical ingredient in the tablet dosage form. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A novel needleless liquid jet injection methodology for improving direct cardiac gene delivery: An optimization of parameters, AAV mediated therapy and investigation of host responses in ischemic heart failure

NASA Astrophysics Data System (ADS)

Fargnoli, Anthony Samuel

Heart disease remains the leading cause of mortality and morbidity worldwide, with 22 million new patients diagnosed annually. Essentially, all present therapies have significant cost burden to the healthcare system, yet fail to increase survival rates. One key employed strategy is the genetic reprogramming of cells to increase contractility via gene therapy, which has advanced to Phase IIb Clinical Trials for advanced heart failure patients. It has been argued that the most significant barrier preventing FDA approval are resolving problems with safe, efficient myocardial delivery, whereby direct injection in the infarct and remote tissue areas is not clinically feasible. Here, we aim to: (1) Improve direct cardiac gene delivery through the development of a novel liquid jet device approach (2) Compare the new method against traditional IM injection with two different vector constructions and evaluate outcome (3) Evaluate the host response resulting from both modes of direct cardiac injection, then advance a drug/gene combination with controlled release nanoparticle formulations.

Thermally-enhanced oil recovery method and apparatus

DOEpatents

Stahl, Charles R.; Gibson, Michael A.; Knudsen, Christian W.

1987-01-01

A thermally-enhanced oil recovery method and apparatus for exploiting deep well reservoirs utilizes electric downhole steam generators to provide supplemental heat to generate high quality steam from hot pressurized water which is heated at the surface. A downhole electric heater placed within a well bore for local heating of the pressurized liquid water into steam is powered by electricity from the above-ground gas turbine-driven electric generators fueled by any clean fuel such as natural gas, distillate or some crude oils, or may come from the field being stimulated. Heat recovered from the turbine exhaust is used to provide the hot pressurized water. Electrical power may be cogenerated and sold to an electric utility to provide immediate cash flow and improved economics. During the cogeneration period (no electrical power to some or all of the downhole units), the oil field can continue to be stimulated by injecting hot pressurized water, which will flash into lower quality steam at reservoir conditions. The heater includes electrical heating elements supplied with three-phase alternating current or direct current. The injection fluid flows through the heater elements to generate high quality steam to exit at the bottom of the heater assembly into the reservoir. The injection tube is closed at the bottom and has radial orifices for expanding the injection fluid to reservoir pressure.

Control of spontaneous combustion of coal in goaf at high geotemperatureby injecting liquid carbon dioxide: inertand cooling characteristics of coal

NASA Astrophysics Data System (ADS)

Liu, Zhenling; Wen, Hu; Yu, Zhijin; Wang, Chao; Ma, Li

2018-02-01

The spontaneous combustion of coal in goaf at high geo temperatures is threatening safety production in coalmine. The TG-DSC is employed to study the variation of mass and energy at 4 atmospheres (mixed gases of N2, O2 and CO2) and heating rates (10°C/min) during oxidation of coal samples. The apparent activation energy and pre-exponential factor of coal oxidation decrease rapidly with increasing theCO2 concentration. Furthermore, its reaction rate is slow, its heat released reduces. Based on the conditions of 1301 face in the Longgucoalmine, a three-dimensional geometry model is developed to simulate the distributions stream field and temperature field and the variation characteristics ofCO2 concentration field after injecting liquidCO2. The results indicate that oxygen reached to depths of˜120m in goaf, 100m in the side of inlet air, and 10m in the side of outlet air before injecting liquidCO2. After injecting liquidCO2for 28.8min, the width of oxidation and heat accumulation zone is shortened by 20m, and the distance is 80m in the side of working face and 40˜60m in goafin the direction of dip affected by temperature.

Control of aldehyde emissions in the diesel engines with alcoholic fuels.

PubMed

Krishna, M V S Murali; Varaprasad, C M; Reddy, C Venkata Ramana

2006-01-01

The major pollutants emitted from compression ignition (CI) engine with diesel as fuel are smoke and nitrogen oxides (NOx). When the diesel engine is run with alternate fuels, there is need to check alcohols (methanol or ethanol) and aldehydes also. Alcohols cannot be used directly in diesel engine and hence engine modification is essential as alcohols have low cetane number and high latent hear of vaporization. Hence, for use of alcohol in diesel engine, it needs hot combustion chamber, which is provided by low heat rejection (LHR) diesel engine with an air gap insulated piston with superni crown and air gap insulated liner with superni insert. In the present study, the pollution levels of aldehydes are reported with the use of methanol and ethanol as alternate fuels in LHR diesel engine with varying injection pressure, injection timings with different percentage of alcohol induction. The aldehydes (formaldehyde and acetaldehyde) in the exhaust were estimated by wet chemical technique with high performance liquid chromatograph (HPLC). Aldehyde emissions increased with an increase in alcohol induction. The LHR engine showed a decrease in aldehyde emissions when compared to conventional engine. However, the variation of injection pressure showed a marginal effect in reducing aldehydes, while advancing the injection timing reduced aldehyde emissions.

Direct push injection logging for high resolution characterization of low permeability zones

NASA Astrophysics Data System (ADS)

Liu, G.; Knobbe, S.; Butler, J. J., Jr.; Reboulet, E. C.; Borden, R. C.; Bohling, G.

2017-12-01

One of the grand challenges for groundwater protection and contaminated site remediation efforts is dealing with the slow, yet persistent, release of contaminants from low permeability zones. In zones of higher permeability, groundwater flow is relatively fast and contaminant transport can be more effectively affected by treatment activities. In the low permeability zones, however, groundwater flow and contaminant transport are slow and thus become largely insensitive to many in-situ treatment efforts. Clearly, for sites with low permeability zones, accurate depiction of the mass exchange between the low and higher permeability zones is critical for designing successful groundwater protection and remediation systems, which requires certain information such as the hydraulic conductivity (K) and porosity of the subsurface. The current generation of field methods is primarily developed for relatively permeable zones, and little work has been undertaken for characterizing zones of low permeability. For example, the direct push injection logging (DPIL) approach (e.g., Hydraulic Profiling Tool by Geoprobe) is commonly used for high resolution estimation of K over a range of 0.03 to 23 m/d. When K is below 0.03 m/d, the pressure responses from the current DPIL are generally too high for both the formation (potential formation alteration at high pressure) and measuring device (pressure exceeding the upper sensor limit). In this work, we modified the current DPIL tool by adding a low-flow pump and flowmeter so that injection logging can be performed with much reduced flow rates when K is low. Numerical simulations showed that the reduction in injection rates (reduced from 250 to 1 mL/min) allowed pressures to be measurable even when K was as low as 0.001 m/d. They also indicated that as the K decreased, the pore water pressure increase induced by probe advancement had a more significant impact on DPIL results. A new field DPIL profiling procedure was developed for reducing that impact. Our preliminary test results in both the lab and at a field site have demonstrated the promise of the modified DPIL approach as a practical method for characterizing low permeability zones.

Where Does the Transplanted Fat is Located in the Gluteal Region? Research Letter.

PubMed

Ramos-Gallardo, Guillermo; Medina-Zamora, Pablo; Cardenas-Camarena, Lázaro; Orozco-Rentería, David; Duran-Vega, Héctor; Mota-Fonseca, Eduardo

2017-12-29

Liposuction is one of the most popular plastic surgery procedures. As in any surgery, there are risks and complications, especially when combined with fat injection. Case reports of fat embolism have been reported. A possible explanation is the puncture and tearing of gluteal vessels during the procedure, especially when a deep injection is planned. To identify the places where fat can be located after injection during a fat graft in the gluteus. An experimental study was done in which colorant was injected in four directions using four different quadrants of the gluteus. We Injected 10 cc six times following clock hands until 60 cc were injected, and the cutaneous flap and the muscles were then elevated. Our main purpose was to describe where the colorant went and if it was in contact with the vessels (superior and inferior gluteal vessels). In total, four gluteus muscles were injected and dissected. Injection in the lower lateral quadrant was mainly into the muscle, and colorant was observed in the hypogastric vessels. The injection in the upper quadrants stayed mainly in the subcutaneous tissue. During surgery, it is important to identify the location of the perforators and to avoid a deep injection, especially from the lower lateral quadrant to the superior medial quadrant (Q4 to Q1), as the probability of puncturing and injecting fat into the main vessels from this direction is higher.

Comparison of carpal tunnel injection techniques: a cadaver study.

PubMed

Ozturk, Kahraman; Esenyel, Cem Zeki; Sonmez, Mesut; Esenyel, Meltem; Kahraman, Sinan; Senel, Berna

2008-01-01

The purpose of the study was to evaluate the accuracy of injections into the carpal tunnel using three different portals in cadavers, and to define safe guidelines. In this study, 150 wrists of 75 cadavers (54 male, 21 female) were included. To compare three injection sites, 50 wrists of 25 cadavers were used for each technique; we used 23 gauge needles, and acrylic dye. The first injection technique: the needle was inserted 1cm proximal to the wrist crease and directed distally by roughly 45 in an ulnar direction through the flexor carpi radialis tendon. The second injection technique: the needle was inserted into the carpal tunnel from a point just ulnar to the palmaris longus tendon and 1cm proximal to the wrist crease. The third injection technique: the needle was inserted just distal to the distal skin crease of the wrist in line with the fourth ray. The first injection technique gave the highest accuracy rate, and this was also the safest injection site. Median nerve injuries caused by injection was seen mostly with the second technique. Although a steroid injection may provide symptomatic relief in patients with carpal tunnel syndrome, the median nerve and other structures in the carpal tunnel are at risk of injury. Because of that, the injection should be given using the correct technique by physicians skilled in carpal tunnel surgery.

THE DETERMINATION OF MERCURY AND MULTIPLE METALS IN DIETARY MATRICES USING DIRECT INJECTION NEBULIZATION INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY (DIN-ICP/MS)

EPA Science Inventory

Mercury (Hg) is a Persistent Bioaccumulative Toxin. Currently, low-level mercury (Hg) and low-level multiple-metals analyses require separate methods. Due to the high costs of performing both types of analyses, research planners often have to choose one or the other. For examp...

Marker retention in the cochlea following injections through the round window membrane

PubMed Central

Salt, Alec N.; Sirjani, Davud B.; Hartsock, Jared J.; Gill, Ruth M.; Plontke, Stefan K.

2007-01-01

Local delivery of drugs to the inner ear is increasingly being used in both clinical and experimental studies. Although direct injection of drugs into perilymph appears to be the most promising way of administering drugs quantitatively, no studies have yet demonstrated the pharmacokinetics in perilymph following direct injections. In this study, we have investigated the retention of substance in perilymph following a single injection into the basal turn of scala tympani (ST). The substance injected was a marker, trimethylphenylammonium (TMPA) that can be detected in low concentrations with ion-selective microelectrodes. Perilymph pharmacokinetics of TMPA was assessed using sequential apical sampling to obtain perilymph for analysis. The amount of TMPA retained in perilymph was compared for different injection and sampling protocols. TMPA concentrations measured in fluid samples were close to those predicted by simulations when the injection pipette was sealed into the bony wall of ST but were systematically lower when the injection pipette was inserted through the round window membrane (RWM). In the latter condition it was estimated that over 60% of the injected TMPA was lost due to leakage of perilymph around the injection pipette at a rate estimated to be 0.09 μL/min. The effects of leakage during and after injections through the RWM were dramatically reduced when the round window niche was filled with 1% sodium hyaluronate gel before penetrating the RWM with the injection pipette. The findings demonstrate that in order to perform quantitative drug injections into perilymph, even small rates of fluid leakage at the injection site must be controlled. PMID:17662546

Direct observation of inversion capacitance in p-type diamond MOS capacitors with an electron injection layer

NASA Astrophysics Data System (ADS)

Matsumoto, Tsubasa; Kato, Hiromitsu; Makino, Toshiharu; Ogura, Masahiko; Takeuchi, Daisuke; Yamasaki, Satoshi; Imura, Masataka; Ueda, Akihiro; Inokuma, Takao; Tokuda, Norio

2018-04-01

The electrical properties of Al2O3/p-type diamond (111) MOS capacitors were studied with the goal of furthering diamond-based semiconductor research. To confirm the formation of an inversion layer in the p-type diamond body, an n-type layer for use as a minority carrier injection layer was selectively deposited onto p-type diamond. To form the diamond MOS capacitors, Al2O3 was deposited onto OH-terminated diamond using atomic layer deposition. The MOS capacitor showed clear inversion capacitance at 10 Hz. The minority carrier injection from the n-type layer reached the inversion n-channel diamond MOS field-effect transistor (MOSFET). Using the high-low frequency capacitance method, the interface state density, D it, within an energy range of 0.1-0.5 eV from the valence band edge energy, E v, was estimated at (4-9) × 1012 cm-2 eV-1. However, the high D it near E v remains an obstacle to improving the field effect mobility for the inversion p-channel diamond MOSFET.

Effects of hole self-trapping by polarons on transport and negative bias illumination stress in amorphous-IGZO

NASA Astrophysics Data System (ADS)

de Jamblinne de Meux, A.; Pourtois, G.; Genoe, J.; Heremans, P.

2018-04-01

The effects of hole injection in amorphous indium-gallium-zinc-oxide (a-IGZO) are analyzed by means of first-principles calculations. The injection of holes in the valence band tail states leads to their capture as a polaron, with high self-trapping energies (from 0.44 to 1.15 eV). Once formed, they mediate the formation of peroxides and remain localized close to the hole injection source due to the presence of a large diffusion energy barrier (of at least 0.6 eV). Their diffusion mechanism can be mediated by the presence of hydrogen. The capture of these holes is correlated with the low off-current observed for a-IGZO transistors, as well as with the difficulty to obtain a p-type conductivity. The results further support the formation of peroxides as being the root cause of Negative Bias Illumination Stress (NBIS). The strong self-trapping substantially reduces the injection of holes from the contact and limits the creation of peroxides from a direct hole injection. In the presence of light, the concentration of holes substantially rises and mediates the creation of peroxides, responsible for NBIS.

Piezoelectric control of needle-free transdermal drug delivery.

PubMed

Stachowiak, Jeanne C; von Muhlen, Marcio G; Li, Thomas H; Jalilian, Laleh; Parekh, Sapun H; Fletcher, Daniel A

2007-12-04

Transdermal drug delivery occurs primarily through hypodermic needle injections, which cause pain, require a trained administrator, and may contribute to the spread of disease. With the growing number of pharmaceutical therapies requiring transdermal delivery, an effective, safe, and simple needle-free alternative is needed. We present and characterize a needle-free jet injector that employs a piezoelectric actuator to accelerate a micron-scale stream of fluid (40-130 microm diameter) to velocities sufficient for skin penetration and drug delivery (50-160 m/s). Existing jet injectors, powered by compressed springs and gases, are not widely used due to painful injections and poor reliability in skin penetration depth and dose. In contrast, our device offers electronic control of the actuator expansion rate, resulting in direct control of jet velocity and thus the potential for more precise injections. We apply a simple fluid-dynamic model to predict the device response to actuator expansion. Further, we demonstrate that injection parameters including expelled volume, jet pressure, and penetration depth in soft materials vary with actuator expansion rate, but are highly coupled. Finally, we discuss how electronically-controlled jet injectors may enable the decoupling of injection parameters such as penetration depth and dose, improving the reliability of needle-free transdermal drug delivery.

Challenges to Safe Injection Practices in Ambulatory Care.

PubMed

Anderson, Laura; Weissburg, Benjamin; Rogers, Kelli; Musuuza, Jackson; Safdar, Nasia; Shirley, Daniel

2017-05-01

Most recent infection outbreaks caused by unsafe injection practices in the United States have occurred in ambulatory settings. We utilized direct observation and a survey to assess injection practices at 31 clinics. Improper vial use was observed at 13 clinics (41.9%). Pharmacy support and healthcare worker education may improve injection practices. Infect Control Hosp Epidemiol 2017;38:614-616.

Regional deposition of nasal sprays in adults: A wide ranging computational study.

PubMed

Kiaee, Milad; Wachtel, Herbert; Noga, Michelle L; Martin, Andrew R; Finlay, Warren H

2018-05-01

The present work examines regional deposition within the nose for nasal sprays over a large and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult nasal airway geometries was defined based on computed tomography images. Deposition in 6 regions of each nasal airway geometry (the vestibule, valve, anterior turbinate, posterior turbinate, olfactory, and nasopharynx) was determined for varying particle diameter, spray cone angle, spray release direction, particle injection speed, and particle injection location. Penetration of nasal spray particles through the airway geometries represented unintended lung exposure. Penetration was found to be relatively insensitive to injection velocity, but highly sensitive to particle size. Penetration remained at or above 30% for particles exceeding 10 μm in diameter for several airway geometries studied. Deposition in the turbinates, viewed as desirable for both local and systemic nasal drug delivery, was on average maximized for particles ranging from ~20 to 30 μm in diameter, and for low to zero injection velocity. Similar values of particle diameter and injection velocity were found to maximize deposition in the olfactory region, a potential target for nose-to-brain drug delivery. However, olfactory deposition was highly variable between airway geometries, with maximum olfactory deposition ranging over 2 orders of magnitude between geometries. This variability is an obstacle to overcome if consistent dosing between subjects is to be achieved for nose-to-brain drug delivery. Copyright © 2018 John Wiley & Sons, Ltd.

Heat transfer to a full-coverage film-cooled surface with 30 degree slant-hole injection

NASA Technical Reports Server (NTRS)

Crawford, M. E.; Kays, W. M.; Moffat, R. J.

1976-01-01

Heat transfer behavior was studied in a turbulent boundary layer with full coverage film cooling through an array of discrete holes and with injection 30 deg to the wall surface in the downstream direction. Stanton numbers were measured for a staggered hole pattern with pitch-to-diameter ratios of 5 and 10, an injection mass flux ratio range of 0.1 to 1.3, and a range of Reynolds number Re sub x of 150,000 to 5 million. Air was used as the working fluid, and the mainstream velocity varied from 9.8 to 34.2 m/sec (32 to 112 ft/sec). The data were taken for secondary injection temperature equal to the wall temperature and also equal to the mainstream temperature. The data may be used to obtain Stanton number as a continuous function of the injectant temperature by use of linear superposition theory. The heat transfer coefficient is defined on the basis of a mainstream-to-wall temperature difference. This definition permits direct comparison of performance between film cooling and transpiration cooling. A differential prediction method was developed to predict the film cooling data base. The method utilizes a two-dimensional boundary layer program with routines to model the injection process and turbulence augmentation. The program marches in the streamwise direction, and when a row of holes is encountered, it stops and injects fluid into the boundary layer. The turbulence level is modeled by algebraically augmenting the mixing length, with the augmentation keyed to a penetration distance for the injected fluid.

Method for creating an aeronautic sound shield having gas distributors arranged on the engines, wings, and nose of an aircraft

NASA Technical Reports Server (NTRS)

Corda, Stephen (Inventor); Smith, Mark Stephen (Inventor); Myre, David Daniel (Inventor)

2008-01-01

The present invention blocks and/or attenuates the upstream travel of acoustic disturbances or sound waves from a flight vehicle or components of a flight vehicle traveling at subsonic speed using a local injection of a high molecular weight gas. Additional benefit may also be obtained by lowering the temperature of the gas. Preferably, the invention has a means of distributing the high molecular weight gas from the nose, wing, component, or other structure of the flight vehicle into the upstream or surrounding air flow. Two techniques for distribution are direct gas injection and sublimation of the high molecular weight solid material from the vehicle surface. The high molecular weight and low temperature of the gas significantly decreases the local speed of sound such that a localized region of supersonic flow and possibly shock waves are formed, preventing the upstream travel of sound waves from the flight vehicle.

High-directionality fiber-chip grating coupler with interleaved trenches and subwavelength index-matching structure.

PubMed

Benedikovic, Daniel; Alonso-Ramos, Carlos; Cheben, Pavel; Schmid, Jens H; Wang, Shurui; Xu, Dan-Xia; Lapointe, Jean; Janz, Siegfried; Halir, Robert; Ortega-Moñux, Alejandro; Wangüemert-Pérez, J Gonzalo; Molina-Fernández, Iñigo; Fédéli, Jean-Marc; Vivien, Laurent; Dado, Milan

2015-09-15

We present the first experimental demonstration of a new fiber-chip grating coupler concept that exploits the blazing effect by interleaving the standard full (220 nm) and shallow etch (70 nm) trenches in a 220 nm thick silicon layer. The high directionality is obtained by controlling the separation between the deep and shallow trenches to achieve constructive interference in the upward direction and destructive interference toward the silicon substrate. Utilizing this concept, the grating directionality can be maximized independent of the bottom oxide thickness. The coupler also includes a subwavelength-engineered index-matching region, designed to reduce the reflectivity at the interface between the injection waveguide and the grating. We report a measured fiber-chip coupling efficiency of -1.3  dB, the highest coupling efficiency achieved to date for a surface grating coupler in a 220 nm silicon-on-insulator platform fabricated in a conventional dual-etch process without high-index overlays or bottom mirrors.

Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9.

PubMed

Honda, Arata; Hirose, Michiko; Sankai, Tadashi; Yasmin, Lubna; Yuzawa, Kazuaki; Honsho, Kimiko; Izu, Haruna; Iguchi, Atsushi; Ikawa, Masahito; Ogura, Atsuo

2015-01-01

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (Cas)-mediated gene targeting via circular plasmid injection in rabbits. The rabbit tyrosinase gene (TYR) was effectively disrupted, and we confirmed germline transmission by pronuclear injection of a circular plasmid expressing humanized Cas9 (hCas9) and single-guide RNA. Direct injection into pronuclear stage zygotes was possible following an in vitro validation assay. Neither off-target mutagenesis nor hCas9 transgenesis was detected in any of the genetically targeted pups and embryos examined. Gene targeting with this rapid and simplified strategy will help accelerate the development of translational research using other nonrodent mammalian species.

In-Situ Contained And Of Volatile Soil Contaminants

DOEpatents

Varvel, Mark Darrell

2005-12-27

The invention relates to a novel approach to containing and removing toxic waste from a subsurface environment. More specifically the present invention relates to a system for containing and removing volatile toxic chemicals from a subsurface environment using differences in surface and subsurface pressures. The present embodiment generally comprises a deep well, a horizontal tube, at least one injection well, at least one extraction well and a means for containing the waste within the waste zone (in-situ barrier). During operation the deep well air at the bottom of well (which is at a high pressure relative to the land surface as well as relative to the air in the contaminated soil) flows upward through the deep well (or deep well tube). This stream of deep well air is directed into the horizontal tube, down through the injection tube(s) (injection well(s)) and into the contaminate plume where it enhances volatization and/or removal of the contaminants.

In-Situ Containment and Extraction of Volatile Soil Contaminants

DOEpatents

Varvel, Mark Darrell

2005-12-27

The invention relates to a novel approach to containing and removing toxic waste from a subsurface environment. More specifically the present invention relates to a system for containing and removing volatile toxic chemicals from a subsurface environment using differences in surface and subsurface pressures. The present embodiment generally comprises a deep well, a horizontal tube, at least one injection well, at least one extraction well and a means for containing the waste within the waste zone (in-situ barrier). During operation the deep well air at the bottom of well (which is at a high pressure relative to the land surface as well as relative to the air in the contaminated soil) flows upward through the deep well (or deep well tube). This stream of deep well air is directed into the horizontal tube, down through the injection tube(s) (injection well(s)) and into the contaminate plume where it enhances volatization and/or removal of the contaminants.

Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

PubMed Central

Honda, Arata; Hirose, Michiko; Sankai, Tadashi; Yasmin, Lubna; Yuzawa, Kazuaki; Honsho, Kimiko; Izu, Haruna; Iguchi, Atsushi; Ikawa, Masahito; Ogura, Atsuo

2014-01-01

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (Cas)-mediated gene targeting via circular plasmid injection in rabbits. The rabbit tyrosinase gene (TYR) was effectively disrupted, and we confirmed germline transmission by pronuclear injection of a circular plasmid expressing humanized Cas9 (hCas9) and single-guide RNA. Direct injection into pronuclear stage zygotes was possible following an in vitro validation assay. Neither off-target mutagenesis nor hCas9 transgenesis was detected in any of the genetically targeted pups and embryos examined. Gene targeting with this rapid and simplified strategy will help accelerate the development of translational research using other nonrodent mammalian species. PMID:25195632

Tumour growth, phagocytic activity and antibody response in corynebacterium parvum-treated mice

PubMed Central

Woodruff, M. F. A.; McBride, W. H.; Dunbar, Noreen

1974-01-01

Serum from both normal and T cell-deprived female adult CBA mice shows a background titre of antibody to Corynebacterium parvum of about 2–4 log2 units by a latex agglutination test. Intraperitoneal injection of C. parvum causes a marked rise in titre which reaches its peak after about a month, and a second injection at that time evokes a further response. Treatment with mercaptoethanol reduces the background titre, and also the titre 1–3 weeks after immunization by 1–2 log units. Subcutaneous injection of C. parvum on the other hand evokes little or no antibody response. Both the antitumour effect of C. parvum, and its effect on clearance of colloidal carbon from the blood stream, can occur in the presence of high levels of antibody directed against the organism. Theoretical and possible therapeutic implications of these findings are discussed. PMID:4549691

Miniaturized flow injection analysis system

DOEpatents

Folta, J.A.

1997-07-01

A chemical analysis technique known as flow injection analysis is described, wherein small quantities of chemical reagents and sample are intermixed and reacted within a capillary flow system and the reaction products are detected optically, electrochemically, or by other means. A highly miniaturized version of a flow injection analysis system has been fabricated utilizing microfabrication techniques common to the microelectronics industry. The microflow system uses flow capillaries formed by etching microchannels in a silicon or glass wafer followed by bonding to another wafer, commercially available microvalves bonded directly to the microflow channels, and an optical absorption detector cell formed near the capillary outlet, with light being both delivered and collected with fiber optics. The microflow system is designed mainly for analysis of liquids and currently measures 38{times}25{times}3 mm, but can be designed for gas analysis and be substantially smaller in construction. 9 figs.

Site-targeted non-viral gene delivery by direct DNA injection into the pancreatic parenchyma and subsequent in vivo electroporation in mice.

PubMed

Sato, Masahiro; Inada, Emi; Saitoh, Issei; Ohtsuka, Masato; Nakamura, Shingo; Sakurai, Takayuki; Watanabe, Satoshi

2013-11-01

The pancreas is considered an important gene therapy target because the organ is the site of several high burden diseases, including diabetes mellitus, cystic fibrosis, and pancreatic cancer. We aimed to develop an efficient in vivo gene delivery system using non-viral DNA. Direct intra-parenchymal injection of a solution containing circular plasmid pmaxGFP DNA was performed on adult anesthetized ICR female mice. The injection site was sandwiched with a pair of tweezer-type electrode disks, and electroporated using a square-pulse generator. Green fluorescent protein (GFP) expression within the injected pancreatic portion was observed one day after gene delivery. GFP expression reduced to baseline within a week of transfection. Application of voltages over 40 V resulted in tissue damage during electroporation. We demonstrate that electroporation is effective for safe and efficient transfection of pancreatic cells. This novel gene delivery method to the pancreatic parenchyma may find application in gene therapy strategies for pancreatic diseases and in investigation of specific gene function in situ. © 2013 The Authors. Biotechnology Journal published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptions are made.

Characterization of a high-pressure diesel fuel injection system as a control technology option to improve engine performance and reduce exhaust emissions

NASA Technical Reports Server (NTRS)

Mcfadden, J. J.; Dezelick, R. A.; Barrows, R. R.

1983-01-01

Test results from a high pressure electronically controlled fuel injection system are compared with a commercial mechanical injection system on a single cylinder, diesel test engine using an inlet boost pressure of 2.6:1. The electronic fuel injection system achieved high pressure by means of a fluid intensifier with peak injection pressures of 47 to 69 MPa. Reduced exhaust emissions were demonstrated with an increasing rate of injection followed by a fast cutoff of injection. The reduction in emissions is more responsive to the rate of injection and injection timing than to high peak injection pressure.

Enhancement of tumor-to-nontumor localization ratios by hepatocyte-directed blood clearance of antibodies labeled with certain residualizing radiolabels.

PubMed

Patel, S; Stein, R; Ong, G L; Goldenberg, D M; Mattes, M J

1999-08-01

To increase tumor-to-nontumor localization ratios of injected radiolabeled antibodies (Abs), several interrelated methods were used. The model systems used were two human carcinoma xenografts grown in nude mice, targeted by antibodies RS11 (antiepithelial glycoprotein-2) or MN-14 (anticarcinoembryonic antigen). The Abs were conjugated with biotin and 111In-benzyl diethylenetriamine pentaacetic acid, and, at various times after injection, were cleared by intraperitoneal injection of galactosylated streptavidin, which delivers the complexes to hepatocytes. The radiolabel used was selected because it is retained within tumors after catabolism of the Ab by the tumor cell but is quite rapidly excreted from hepatocytes into bile. With blood clearance induced at 24 h, and dissection 5 h later, high tumor-to-nontumor ratios were attained. Depending on the model used, tumor-to-blood ratios were 16:1 to 31:1, and tumor-to-nontumor ratios for the kidney, lungs and bone were also high and greatly increased by the clearance regimen. Despite clearance into the liver, tumor-to-liver ratios remained >1, due to fairly rapid biliary excretion of the label. The absolute antibody uptake by the tumors was also high, because 24 h was allowed for the Ab to penetrate and bind to cells within the subcutaneous tumors. The method described produced high tumor-to-nontumor ratios at 1 d after injection and may be advantageous for tumor imaging with antibodies. Radiation dosimetry calculations indicate that there is only a slight advantage with this approach for radioimmunotherapy.

Unambiguous identification and discovery of bacterial siderophores by direct injection 21 Tesla Fourier transform ion cyclotron resonance mass spectrometry.

PubMed

Walker, Lawrence R; Tfaily, Malak M; Shaw, Jared B; Hess, Nancy J; Paša-Tolić, Ljiljana; Koppenaal, David W

2017-01-25

Under iron-limiting conditions, bacteria produce low molecular mass Fe(iii) binding molecules known as siderophores to sequester the Fe(iii), along with other elements, increasing their bioavailability. Siderophores are thought to influence iron cycling and biogeochemistry in both marine and terrestrial ecosystems and hence the need for rapid, confident characterization of these compounds has increased. In this study, the type of siderophores produced by two marine bacterial species, Synechococcus sp. PCC 7002 and Vibrio cyclitrophicus 1F53, were characterized by use of a newly developed 21 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR MS) with direct injection electrospray ionization. This technique allowed for the rapid detection of synechobactins from Synechococcus sp. PCC 7002 as well as amphibactins from Vibrio cyclitrophicus 1F53 based on high mass accuracy and resolution allowing for observation of specific Fe isotopes and isotopic fine structure enabling highly confident identification of these siderophores. When combined with molecular network analysis two new amphibactins were discovered and verified by tandem MS. These results show that high-field FTICR MS is a powerful technique that will greatly improve the ability to rapidly identify and discover metal binding species in the environment.

Unambiguous identification and discovery of bacterial siderophores by direct injection 21 Tesla Fourier transform ion cyclotron resonance mass spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, Lawrence R.; Tfaily, Malak M.; Shaw, Jared B.

Under iron-limiting conditions, bacteria produce low molecular mass Fe(III) binding molecules known as siderophores to sequester the Fe(III), along with other elements, increasing their bioavailibility. Siderophores are thought to influence iron cycling and biogeochemistry in both marine and terrestrial ecosystems and hence the need for rapid, confident characterization of these compounds has increased. In this study, the type of siderophores produced by two marine bacterial species, Synechococcus sp. PCC 7002 and Vibrio cyclitrophicus 1F53, were characterized using a newly developed 21T Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR MS) with direct injection electrospray ionization. This technique allowed for themore » rapid detection of synechobactins from Synechococcus sp. PCC 7002 as well as amphibactins from Vibrio cyclitrophicus 1F53 based on high mass accuracy and resolution allowing for observation of specific Fe isotopic peaks and fine isotopic structure enables highly confident identification of these sideropohores. When combined with molecular network analysis two new amphibactins were discovered and verified by tandem MS. These results show that high-field FTICR MS is a powerful technique that will greatly improve the ability to rapidly identify and discover metal binding species in the environment.« less

Site-directed decapsulation of bolaamphiphilic vesicles with enzymatic cleavable surface groups.

PubMed

Popov, Mary; Grinberg, Sarina; Linder, Charles; Waner, Tal; Levi-Hevroni, Bosmat; Deckelbaum, Richard J; Heldman, Eliahu

2012-06-10

Stable nano-sized vesicles with a monolayer encapsulating membrane were prepared from novel bolaamphiphiles with choline ester head groups. The head groups were covalently bound to the alkyl chain of the bolaamphiphiles either via the nitrogen atom of the choline moiety, or via the choline ester's methyl group. Both types of bolaamphiphiles competed with acetylthiocholine for binding to acetylcholine esterase (AChE), yet, only the choline ester head groups bound to the alkyl chain via the nitrogen atom of the choline moiety were hydrolyzed by the enzyme. Likewise, only vesicles composed of bolaamphiphiles with head groups that were hydrolyzed by AChE released their encapsulated material upon exposure to the enzyme. Injection of carboxyfluorescein (CF)-loaded vesicles with cleavable choline ester head groups into mice resulted in the accumulation of CF in tissues that express high AChE activity, including the brain. By comparison, when vesicles with choline ester head groups that are not hydrolyzed by AChE were injected into mice, there was no accumulation of CF in tissues that highly express the enzyme. These results imply that bolaamphiphilic vesicles with surface groups that are substrates to enzymes which are highly expressed in target organs may potentially be used as a drug delivery system with controlled site-directed drug release. Copyright © 2011 Elsevier B.V. All rights reserved.

Simulation of a Single-Element Lean-Direct Injection Combustor Using a Polyhedral Mesh Derived from Hanging-Node Elements

NASA Technical Reports Server (NTRS)

Wey, Thomas; Liu, Nan-Suey

2013-01-01

This paper summarizes the procedures of generating a polyhedral mesh derived from hanging-node elements as well as presents sample results from its application to the numerical solution of a single element lean direct injection (LDI) combustor using an open-source version of the National Combustion Code (NCC).

THE DEVELOPMENT OF IODINE BASED IMPINGER SOLUTIONS FOR THE EFFICIENT CAPTURE OF HG USING DIRECT INJECTION NEBULIZATION - INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY ANALYSIS

EPA Science Inventory

Inductively coupled plasma mass spectrometry (ICP/MS) with direct injection nebulization (DIN) was used to evaluate novel impinger solution compositions capable of capturing elemental mercury (Hgo) in EPA Method 5 type sampling. An iodine based impinger solutoin proved to be ver...

Direct-injection chemiluminescence detector. Properties and potential applications in flow analysis.

PubMed

Koronkiewicz, Stanislawa; Kalinowski, Slawomir

2015-02-01

We present a novel chemiluminescence detector, with a cone-shaped detection chamber where the analytical reaction takes place. The sample and appropriate reagents are injected directly into the chamber in countercurrent using solenoid-operated pulse micro-pumps. The proposed detector allows for fast measurement of the chemiluminescence signal in stop-flow conditions from the moment of reagents mixing. To evaluate potential applications of the detector the Fenton-like reaction with a luminol-H2O2 system and several transition metal ions (Co(2+), Cu(2+), Cr(3+), Fe(3+)) as a catalyst were investigated. The results demonstrate suitability of the proposed detector for quantitative analysis and for investigations of reaction kinetics, particularly rapid reactions. A multi-pumping flow system was designed and optimized. The developed methodology demonstrated that the shape of the analytical signals strongly depends on the type and concentration of the metal ions. The application of the detector in quantitative analysis was assessed for determination of Fe(III). The direct-injection chemiluminescence detector allows for a sensitive and repeatable (R.S.D. 2%) determination. The intensity of chemiluminescence increased linearly in the range from about 0.5 to 10 mg L(-1) Fe(III) with the detection limit of 0.025 mg L(-1). The time of analysis depended mainly on reaction kinetics. It is possible to achieve the high sampling rate of 144 samples per hour. Copyright © 2014 Elsevier B.V. All rights reserved.

Focused ion beam direct micromachining of DOEs

NASA Astrophysics Data System (ADS)

Khan Malek, Chantal; Hartley, Frank T.; Neogi, Jayant

2000-09-01

We discuss here the capability of direct manufacture of various high- resolution diffractive optics, in particular regarding micromachining of DOEs in 3D. Preliminary demonstrations were made in 2-D using an automated FIB system operated at 30 KeV with a Gallium liquid metal ion source and equipped with a gas injection system (GIS). Gratings with a 20 nm line width and zone plates with 32 nm outer ring were milled in a reactive atmosphere (iodine) directly through 3.5 (mu) m and 800 nm of gold respectively. Plans for combining FIB and X-ray lithography to make diffractive optical elements (DOEs) for JPL are also mentioned.

Preferred carbon precursors for lipid labelling in the heterotrophic endosperm of developing oat (Avena sativa L.) grains.

PubMed

Grimberg, Åsa

2014-10-01

Oat (Avena sativa L.) is unusual among the cereal grains in storing high amounts of oil in the endosperm; up to 90% of total grain oil. By using oat as a model species for oil metabolism in the cereal endosperm, we can learn how to develop strategies to redirect carbon from starch to achieve high-oil yielding cereal crops. Carbon precursors for lipid synthesis were compared in two genetically close oat cultivars with different endosperm oil content (about 6% and 10% of grain dw, medium-oil; MO, and high-oil; HO cultivar, respectively) by supplying a variety of (14)C-labelled substrates to the grain from both up- and downstream parts of glycolysis, either through detached oat panicles in vitro or by direct injection in planta. When supplied by direct injection, (14)C from acetate was identified to label the lipid fraction of the grain to the highest extent among substrates tested; 46% of net accumulated (14)C, demonstrating its applicability as a marker for lipids in the endosperm. Time course analyses of injected (14)C acetate during grain development suggested a more efficient transfer of fatty acids from polar lipids to triacylglycerol in the HO as compared to the MO cultivar, and turnover of triacylglycerol was suggested to not play a major role for the final oil content of oat grain endosperm despite the low amount of protective oleosins in this tissue. Moreover, availability of light was shown to drastically affect grain net carbon accumulation from (14)C-sucrose when supplied through detached panicles for the HO cultivar. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Direct injection GC method for measuring light hydrocarbon emissions from cooling-tower water.

PubMed

Lee, Max M; Logan, Tim D; Sun, Kefu; Hurley, N Spencer; Swatloski, Robert A; Gluck, Steve J

2003-12-15

A Direct Injection GC method for quantifying low levels of light hydrocarbons (C6 and below) in cooling water has been developed. It is intended to overcome the limitations of the currently available technology. The principle of this method is to use a stripper column in a GC to strip waterfrom the hydrocarbons prior to entering the separation column. No sample preparation is required since the water sample is introduced directly into the GC. Method validation indicates that the Direct Injection GC method offers approximately 15 min analysis time with excellent precision and recovery. The calibration studies with ethylene and propylene show that both liquid and gas standards are suitable for routine calibration and calibration verification. The sampling method using zero headspace traditional VOA (Volatile Organic Analysis) vials and a sample chiller has also been validated. It is apparent that the sampling method is sufficient to minimize the potential for losses of light hydrocarbons, and samples can be held at 4 degrees C for up to 7 days with more than 93% recovery. The Direct Injection GC method also offers <1 ppb (w/v) level method detection limits for ethylene, propylene, and benzene. It is superior to the existing El Paso stripper method. In addition to lower detection limits for ethylene and propylene, the Direct Injection GC method quantifies individual light hydrocarbons in cooling water, provides better recoveries, and requires less maintenance and setup costs. Since the instrumentation and supplies are readily available, this technique could easily be established as a standard or alternative method for routine emission monitoring and leak detection of light hydrocarbons in cooling-tower water.

Direct memory access transfer completion notification

DOEpatents

Chen, Dong; Giampapa, Mark E.; Heidelberger, Philip; Kumar, Sameer; Parker, Jeffrey J.; Steinmacher-Burow, Burkhard D.; Vranas, Pavlos

2010-07-27

Methods, compute nodes, and computer program products are provided for direct memory access (`DMA`) transfer completion notification. Embodiments include determining, by an origin DMA engine on an origin compute node, whether a data descriptor for an application message to be sent to a target compute node is currently in an injection first-in-first-out (`FIFO`) buffer in dependence upon a sequence number previously associated with the data descriptor, the total number of descriptors currently in the injection FIFO buffer, and the current sequence number for the newest data descriptor stored in the injection FIFO buffer; and notifying a processor core on the origin DMA engine that the message has been sent if the data descriptor for the message is not currently in the injection FIFO buffer.

Integration of On-Chip Peristaltic Pumps and Injection Valves with Microchip Electrophoresis and Electrochemical Detection

PubMed Central

Bowen, Amanda L; Martin, R. Scott

2010-01-01

A microfluidic approach that integrates peristaltic pumping from an on-chip reservoir with injection valves, microchip electrophoresis and electrochemical detection is described. Fabrication and operation of both the peristaltic pumps and injection valves were optimized to ensure efficient pumping and discrete injections. The final device uses the peristaltic pumps to continuously direct sample from a reservoir containing a mixture of analytes to injection valves that are coupled with microchip electrophoresis and amperometric detection. The separation and direct detection of dopamine and norepinephrine were possible with this approach and the utility of the device was demonstrated by monitoring the stimulated release of these neurotransmitters from a layer of cells introduced into the microchip. It is also shown that this pumping/reservoir approach can be expanded to multiple reservoirs and pumps, where one reservoir can be addressed individually or multiple reservoirs sampled simultaneously. PMID:20665914

Modeling Primary Atomization of Liquid Fuels using a Multiphase DNS/LES Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arienti, Marco; Oefelein, Joe; Doisneau, Francois

2016-08-01

As part of a Laboratory Directed Research and Development project, we are developing a modeling-and-simulation capability to study fuel direct injection in automotive engines. Predicting mixing and combustion at realistic conditions remains a challenging objective of energy science. And it is a research priority in Sandia’s mission-critical area of energy security, being also relevant to many flows in defense and climate. High-performance computing applied to this non-linear multi-scale problem is key to engine calculations with increased scientific reliability.

Tuning the superstructure of ultrahigh-molecular-weight polyethylene/low-molecular-weight polyethylene blend for artificial joint application.

PubMed

Xu, Ling; Chen, Chen; Zhong, Gan-Ji; Lei, Jun; Xu, Jia-Zhuang; Hsiao, Benjamin S; Li, Zhong-Ming

2012-03-01

An easy approach was reported to achieve high mechanical properties of ultrahigh-molecular-weight polyethylene (UHMWPE)-based polyethylene (PE) blend for artificial joint application without the sacrifice of the original excellent wear and fatigue behavior of UHMWPE. The PE blend with desirable fluidity was obtained by melt mixing UHMWPE and low molecular weight polyethylene (LMWPE), and then was processed by a modified injection molding technology-oscillatory shear injection molding (OSIM). Morphological observation of the OSIM PE blend showed LMWPE contained well-defined interlocking shish-kebab self-reinforced superstructure. Addition of a small amount of long chain polyethylene (2 wt %) to LMWPE greatly induced formation of rich shish-kebabs. The ultimate tensile strength considerably increased from 27.6 MPa for conventional compression molded UHMWPE up to 78.4 MPa for OSIM PE blend along the flow direction and up to 33.5 MPa in its transverse direction. The impact strength of OSIM PE blend was increased by 46% and 7% for OSIM PE blend in the direction parallel and vertical to the shear flow, respectively. Wear and fatigue resistance were comparable to conventional compression molded UHMWPE. The superb performance of the OSIM PE blend was originated from formation of rich interlocking shish-kebab superstructure while maintaining unique properties of UHMWPE. The present results suggested the OSIM PE blend has high potential for artificial joint application. © 2012 American Chemical Society

Numerical Modelling of Staged Combustion Aft-Injected Hybrid Rocket Motors

NASA Astrophysics Data System (ADS)

Nijsse, Jeff

The staged combustion aft-injected hybrid (SCAIH) rocket motor is a promising design for the future of hybrid rocket propulsion. Advances in computational fluid dynamics and scientific computing have made computational modelling an effective tool in hybrid rocket motor design and development. The focus of this thesis is the numerical modelling of the SCAIH rocket motor in a turbulent combustion, high-speed, reactive flow framework accounting for solid soot transport and radiative heat transfer. The SCAIH motor is modelled with a shear coaxial injector with liquid oxygen injected in the center at sub-critical conditions: 150 K and 150 m/s (Mach ≈ 0.9), and a gas-generator gas-solid mixture of one-third carbon soot by mass injected in the annual opening at 1175 K and 460 m/s (Mach ≈ 0.6). Flow conditions in the near injector region and the flame anchoring mechanism are of particular interest. Overall, the flow is shown to exhibit instabilities and the flame is shown to anchor directly on the injector faceplate with temperatures in excess of 2700 K.

Flame Tube NOx Emissions Using a Lean-Direct-Wall-Injection Combustor Concept

NASA Technical Reports Server (NTRS)

Tacina, Robert R.; Wey, Changlie; Choi, Kyung J.

2001-01-01

A low-NOx emissions combustor concept has been demonstrated in flame tube tests. A lean-direct injection concept was used where the fuel is injected directly into the flame zone and the overall fuel-air mixture is lean. In this concept the air is swirled upstream of a venturi section and the fuel is injected radially inward into the air stream from the throat section using a plain-orifice injector. Configurations have two-, four-, or six-wall fuel injectors and in some cases fuel is also injected from an axially located simplex pressure atomizer. Various orifice sizes of the plain-orifice injector were evaluated for the effect on NOx. Test conditions were inlet temperatures up to 8 1 OK, inlet pressures up to 2760 kPa, and flame temperatures up to 2100 K. A correlation is developed relating the NOx emissions to inlet temperature, inlet pressure, fuel-air ratio and pressure drop. Assuming that 15 percent of the combustion air would be used for liner cooling and using an advanced engine cycle, for the best configuration, the NOx emissions using the correlation is estimated to be <75 percent of the 1996 ICAO standard.

Applications of 1.55 μm optically injection-locked VCSELs in wavelength division multiplexed passive optical networks

NASA Astrophysics Data System (ADS)

Wong, Elaine; Zhao, Xiaoxue; Chang-Hasnain, Connie J.; Hofmann, Werner; Amann, Marcus C.

2007-11-01

In this paper, we will discuss the utilization of optically injection-locked (OIL) 1.55 μm vertical-cavity surface-emitting lasers (VCSELs) for operation as low-cost, stable, directly modulated, and potentially uncooled transmitters, whereby the injection-locking master source is furnished by modulated downstream signals. Such a transmitter will find useful application in wavelength division multiplexed passive optical networks (WDM-PONs) which is actively being developed to meet the ever-increasing bandwidth demands of end users. Our scheme eliminates the need for external injection locking optical sources, external modulators, and wavelength stabilization circuitry. We show through experiments that the injection-locked VCSEL favors low injection powers and responds only strongly to the carrier but not the modulated data of the downstream signal. Further, we will discuss results from experimental studies performed on the dependence of OIL-VCSELs in bidirectional networks on the degree of Rayleigh backscattered signal and extinction ratio. We show that error-free upstream performance can be achieved when the upstream signal to Rayleigh backscattering ratio is greater than 13.4 dB, and with minimal dependence on the downstream extinction ratio. We will also review a fault monitoring and localization scheme based on a highly-sensitive yet low-cost monitor comprising a low output power broadband source and low bandwidth detectors. The proposed scheme benefits from the high reflectivity top distributed Bragg reflector mirror of the OIL-VCSEL, incurring only a minimal penalty on the upstream transmissions of the existing infrastructure. Such a scheme provides fault monitoring without having to further invest in the upgrade of customer premises.

DESIGN OF A HIGH COMPRESSION, DIRECT INJECTION, SPARK-IGNITION, METHANOL FUELED RESEARCH ENGINE WITH AN INTEGRAL INJECTOR-IGNITION SOURCE INSERT, SAE PAPER 2001-01-3651

EPA Science Inventory

A stratified charge research engine and test stand were designed and built for this work. The primary goal of this project was to evaluate the feasibility of using a removal integral injector ignition source insert which allows a convenient method of charging the relative locat...

Survey of inlet noise reduction concepts for gas turbine engines

NASA Technical Reports Server (NTRS)

Lansing, D. L.; Chestnutt, D.

1976-01-01

This paper presents an overview of advanced concepts for the suppression of noise in the inlets of gas turbine engines. Noise suppression concepts are described, the directions of current research are reviewed, and problem areas requiring further work are indicated. The discussion focuses on acoustic liners, high Mach number inlets, active acoustic absorption, water vapor injection, and blade row reflection.

False Operation of Static Random Access Memory Cells under Alternating Current Power Supply Voltage Variation

NASA Astrophysics Data System (ADS)

Sawada, Takuya; Takata, Hidehiro; Nii, Koji; Nagata, Makoto

2013-04-01

Static random access memory (SRAM) cores exhibit susceptibility against power supply voltage variation. False operation is investigated among SRAM cells under sinusoidal voltage variation on power lines introduced by direct RF power injection. A standard SRAM core of 16 kbyte in a 90 nm 1.5 V technology is diagnosed with built-in self test and on-die noise monitor techniques. The sensitivity of bit error rate is shown to be high against the frequency of injected voltage variation, while it is not greatly influenced by the difference in frequency and phase against SRAM clocking. It is also observed that the distribution of false bits is substantially random in a cell array.

S-band 1.4 cell photoinjector design for high brightness beam generation

NASA Astrophysics Data System (ADS)

Pirez, E.; Musumeci, P.; Maxson, J.; Alesini, D.

2017-09-01

In this paper we study in detail the design of a novel S-band radiofrequency photogun structure to maximize the accelerating field experienced by the particles at injection. This is a critical quantity for electron sources as it has a direct impact on the maximum brightness achievable. The proposed design is based on a modification of the latest generation of S-band RF photoinjectors to include novel fabrication approaches. The gun is designed to operate at a 120 MV/m gradient and at an optimal injection phase of 70° providing the beam quality required to enable novel electron beam applications such as single shot time-resolved transmission electron microscopy and ultrafast electron nanodiffraction.

Two-dimensional analysis of two-phase reacting flow in a firing direct-injection diesel engine

NASA Technical Reports Server (NTRS)

Nguyen, H. Lee

1989-01-01

The flow field, spray penetration, and combustion in two-stroke diesel engines are described. Fuel injection begins at 345 degrees after top dead center (ATDC) and n-dodecane is used as the liquid fuel. Arrhenius kinetics is used to calculate the reaction rate term in the quasi-global combustion model. When the temperature, fuel, and oxygen mass fraction are within suitable flammability limits, combustion begins spontaneously. No spark is necessary to ignite a localized high temperature region. Compression is sufficient to increase the gaseous phase temperature to a point where spontaneous chemical reactions occur. Results are described for a swirl angle of 22.5 degrees.

Microscopic models of non-radiative and high-current effects in LEDs: state of the art and future developments

NASA Astrophysics Data System (ADS)

Bertazzi, Francesco; Goano, Michele; Calciati, Marco; Zhou, Xiangyu; Ghione, Giovanni; Bellotti, Enrico

2014-02-01

Auger recombination is at the hearth of the debate on droop, the decline of the internal quantum efficiency at high injection levels. The theory of Auger recombination in quantum wells is reviewed. The proposed microscopic model is based on a full-Brillouin-zone description of the electronic structure obtained by nonlocal empirical pseudopotential calculations and the linear combination of bulk bands. The lack of momentum conservation along the confining direction in InGaN/GaN quantum wells enhances direct (i.e. phononless) Auger transitions, leading to Auger coefficients in the range of those predicted for phonon-dressed processes in bulk InGaN.

Polarization-dependent coupling between a polarization-independent high-index-contrast subwavelength grating and waveguides

NASA Astrophysics Data System (ADS)

Katayama, Takeo; Ito, Jun; Kawaguchi, Hitoshi

2016-07-01

We investigated the optical coupling between a polarization-independent high-index-contrast subwavelength grating (HCG) and two orthogonal in-plane waveguides. We fabricated the HCG with waveguides on a silicon-on-insulator substrate and demonstrated that a waveguide with a strong output is switched by changing the polarization of light injected into the HCG. The light coupled more strongly to the waveguide in the direction perpendicular to the polarization of the incident light than to that in the parallel direction. If this waveguide-coupled HCG is incorporated into a polarization bistable vertical-cavity surface-emitting laser (VCSEL), the output waveguide can be switched by changing the lasing polarization of the VCSEL.

Dynamics of collision of a vortex ring and a planar surface

NASA Astrophysics Data System (ADS)

McErlean, Michael; Krane, Michael; Fontaine, Arnold

2009-11-01

The dynamics of the impact between a vortex ring and a planar surface orientated perpendicular to the direction of travel are presented. High Reynolds number vortex rings are injected into a quiescent tank of water using a piston-cylinder generator before colliding with a target at a long distance. Both the pressure at the stagnation point on the surface and the force imparted to the target by the ring impact are measured directly. The changes in both are related to the ring motion and deformation captured by high speed digital video, and DPIV measurements. These relations are used to develop a scaling law relation between impact force and vortex ring circulation, speed, and size.

Superconductor fiber elongation with a heated injected gas

DOEpatents

Zeigler, Douglas D.; Conrad, Barry L.; Gleixner, Richard A.

2001-01-16

An improved method and apparatus for producing flexible fibers (30) of superconducting material includes a crucible (12) for containing a charge of the superconducting material. The material is melted in the crucible (12) and falls in a stream (18) through a bottom hole (16) in the crucible (12). The stream (18) falls through a protecting collar (22) which maintains the stream (18) at high temperatures. The stream (18) is then supplied through a downwardly directed nozzle (26) where it is subjected to a high velocity of a heated gas (36') which breaks the melted superconducting material into ligaments which solidify into the flexible fibers (30). The fibers (30) are collected by directing them against a collection filter (32).

Superconductor fiber elongation with a heated injected gas

DOEpatents

Zeigler, Douglas D.; Conrad, Barry L.; Gleixner, Richard A.

1998-06-02

An improved method and apparatus for producing flexible fibers (30) of superconducting material includes a crucible (12) for containing a charge of the superconducting material. The material is melted in the crucible (12) and falls in a stream (18) through a bottom hole (16) in the crucible (12). The stream (18) falls through a protecting collar (22) which maintains the stream (18) at high temperatures. The stream (18) is then supplied through a downwardly directed nozzle (26) where it is subjected to a high velocity of a heated gas (36') which breaks the melted superconducting material into ligaments which solidify into the flexible fibers (30). The fibers (30) are collected by directing them against a collection filter (32).

Functional integration of PCR amplification and capillary eletrophoresis in a microfabricated DNA analysis device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woolley, A.T.; deMello, A.J.; Mathies, R.A.

Microfabricated silicon PCR reactors and glass capillary electrophoresis (CE) chips have been successfully coupled to form an integrated DNA analysis system. This construct combines the rapid thermal cycling capabilities of microfabricated PCR devices (10{degree}C/s heating, 2.5{degree}C/s cooling) with the high-speed (<120 s) DNA separations provided by microfabricated CE chips. The PCR chamber and the CE chip were directly linked through a photolithographically fabricated channel filled with hydroxyethylcellulose sieving matrix. Electrophoretic injection directly from the PCR chamber through the cross injection channel was used as an `electrophoretic valve` to couple the PCR and CE devices on-chip. To demonstrate the functionality ofmore » this system, a 15 min PCR amplification of a {Beta}-globin target cloned in m13 was immediately followed by high-speed CE chip separation in under 120 s, providing a rapid PCR-CE analysis in under 20 min. A rapid assay for genomic Salmonella DNA was performed in under 45 min, demonstrating that challenging amplifications of diagnostically interesting targets can also be performed. Real-time monitoring of PCR target amplification in these integrated PCR-CE devices is also feasible. 33 refs., 6 figs.« less

Theory and Modeling of Petawatt Laser Pulse Propagation in Low Density Plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shadwick, Bradley A.; Kalmykov, S. Y.

Report describing accomplishments in all-optical control of self-injection in laser-plasma accelerators and in developing advanced numerical models of laser-plasma interactions. All-optical approaches to controlling electron self-injection and beam formation in laser-plasma accelerators (LPAs) were explored. It was demonstrated that control over the laser pulse evolution is the key ingredient in the generation of low-background, low-phase-space-volume electron beams. To this end, preserving a smooth laser pulse envelope throughout the acceleration process can be achieved through tuning the phase and amplitude of the incident pulse. A negative frequency chirp compensates the frequency red-shift accumulated due to wake excitation, preventing evolution of themore » pulse into a relativistic optical shock. This reduces the ponderomotive force exerted on quiescent plasma electrons, suppressing expansion of the bubble and continuous injection of background electrons, thereby reducing the charge in the low-energy tail by an order of magnitude. Slowly raising the density in the pulse propagation direction locks electrons in the accelerating phase, boosting their energy, keeping continuous injection at a low level, tripling the brightness of the quasi-monoenergetic component. Additionally, propagating the negatively chirped pulse in a plasma channel suppresses diffraction of the pulse leading edge, further reducing continuous injection. As a side effect, oscillations of the pulse tail may be enhanced, leading to production of low-background, polychromatic electron beams. Such beams, consisting of quasi-monoenergetic components with controllable energy and energy separation, may be useful as drivers of polychromatic x-rays based on Thomson backscattering. These all-optical methods of electron beam quality control are critically important for the development of future compact, high-repetition-rate, GeV-scale LPA using 10 TW-class, ultra-high bandwidth pulses and mm-scale, dense plasmas. These results emphasize that investment into new pulse amplification techniques allowing for ultrahigh frequency bandwidth is as important for the design of future LPA as are the current efforts directed to increasing the pulse energy.« less

Managing the Risk of Triggered Seismicity: Can We Identify (and Avoid) Potentially Active Faults? - A Practical Case Study in Oklahoma

NASA Astrophysics Data System (ADS)

Zoback, M. D.; Alt, R. C., II; Walsh, F. R.; Walters, R. J.

2014-12-01

It is well known that throughout the central and eastern U.S. there has been a marked increase in seismicity since 2009, at least some of which appears to increased wastewater injection. No area has seen a greater increase in seismicity than Oklahoma. In this paper, we utilize newly available information on in situ stress orientation and relative magnitudes, the distribution of high volume injection wells and knowledge of the intervals used for waste water disposal to identify the factors potentially contributing to the occurrence of triggered seismicity. While there are a number of sites where in situ stress data has been successfully used to identify potentially active faults, we are investigating whether this methodology can be implemented throughout a state utilizing the types of information frequently available in areas of oil and gas development. As an initial test of this concept, we have been compiling stress orientation data from wells throughout Oklahoma provided by private industry. Over fifty new high quality data points, principally drilling-induced tensile fractures observed in image logs, result in a greatly improved understanding of the stress field in much of the state. A relatively uniform ENE direction of maximum compressive stress is observed, although stress orientations (and possibly relative stress magnitudes) differ in the southern and southwestern parts of the state. The proposed methodology can be tested in the area of the NE-trending fault that produced the M 5+ earthquakes in the Prague, OK sequence in 2011, and the Meers fault in southwestern OK, that produced a M~7 reverse faulting earthquake about 1100 years ago. This methodology can also be used to essentially rule out slip on other major faults in the area, such as the ~N-S trending Nemaha fault system. Additional factors leading to the occurrence of relatively large triggered earthquakes in Oklahoma are 1) the overall increase in injection volumes throughout the state in recent years (especially in some particular areas) 2) the injection of waste water in a geologic formation laying directly above crystalline basement rocks and 3) the widespread distribution of injection wells.

Gaseous Emissions Results from a Three-Cup Flametube Test of a Third-Generation Swirl-Venturi Lean Direct Injection Combustion Concept

NASA Technical Reports Server (NTRS)

Tacina, Kathleen M.; Podboy, Derek P.; Lee, Phil; Dam, Bidhan

2017-01-01

This paper summarizes the development of lean direct injection (LDI) combustor technology at, or in collaboration with, the NASA Glenn Research Center. These configurations differ mainly in fuel-air mixing strategy. The paper reviews the NOx performance and operability characteristics of multiple LDI configurations tested at NASA Glenn.

Vertical-Deformation, Water-Level, Microgravity, Geodetic, Water-Chemistry, and Flow-Rate Data Collected During Injection, Storage, and Recovery Tests at Lancaster, Antelope Valley, California, September 1995 Through September 1998

DTIC Science & Technology

2002-01-01

63 Tiltmeter Network...71 34. Map showing locations of tiltmeters used to monitor the magnitude and direction of ground tilting associated with direct well injection...during cycle 2 at Lancaster, Antelope Valley, California .............................. 72 35. Photograph showing typical tiltmeter installation for

Flex-Fuel Two-Stroke Snowmobile: Development of a Flex-Fuel, Two-Stroke, Direct-Injection Snowmobile for Use in the Clean Snowmobile Challenge and National Parks

DOT National Transportation Integrated Search

2009-09-01

The University of Idaho's entry into the 2009 SAE Clean Snowmobile Challenge (CSC) was a semi-direct-injection (SDI) two-stroke powered REV-XP snowmobile modified to use flex fuel. The flex fuel engine produces stock engine power on any blend of etha...

Low Emission Hydrogen Combustors for Gas Turbines Using Lean Direct Injection

NASA Technical Reports Server (NTRS)

Marek, C. John; Smith, Timothy D.; Kundu, Krishna

2005-01-01

One of the key technology challenges for the use of hydrogen in gas turbine engines is the performance of the combustion system, in particular the fuel injectors. To investigate the combustion performance of gaseous hydrogen fuel injectors flame tube combustor experiments were performed. Tests were conducted to measure the nitrogen oxide (NOx) emissions and combustion performance at inlet conditions of 600 to 1000 deg F, 60 to 200 pounds per square inch absolute (psia), and equivalence ratios up to 0.48. All the injectors were based on Lean Direct Injection (LDI) technology with multiple injection points and quick mixing. One challenge to hydrogen based premixing combustion systems is flashback since hydrogen has a reaction rate over seven times that of Jet-A. To reduce the risk, design mixing times were kept short and velocities high to minimize flashback. Five fuel injector designs were tested in 2.5 and 3.5-in. diameter flame tubes with non-vitiated heated air and gaseous hydrogen. Data is presented on measurements of NOx emissions and combustion efficiency for the hydrogen injectors at 1.0, 3.125, and 5.375 in. from the injector face. Results show that for some configurations, NOx emissions are comparable to that of state of the art Jet-A LDI combustor concepts.

Low-Emission Hydrogen Combustors for Gas Turbines Using Lean Direct Injection

NASA Technical Reports Server (NTRS)

Marek, C. John; Smith, Timothy D.; Kundu, Krishna

2007-01-01

One of the key technology challenges for the use of hydrogen in gas turbine engines is the performance of the combustion system, in particular the fuel injectors. To investigate the combustion performance of gaseous hydrogen fuel injectors flame tube combustor experiments were performed. Tests were conducted to measure the nitrogen oxide (NO(x)) emissions and combustion performance at inlet conditions of 588 to 811 K, 0.4 to 1.4 MPa, and equivalence ratios up to 0.48. All the injectors were based on Lean Direct Injection (LDI) technology with multiple injection points and quick mixing. One challenge to hydrogen-based premixing combustion systems is flashback since hydrogen has a reaction rate over 7 times that of Jet-A. To reduce the risk, design mixing times were kept short and velocities high to minimize flashback. Five fuel injector designs were tested in 6.35- and 8.9-cm-diameter flame tubes with non-vitiated heated air and gaseous hydrogen. Data is presented on measurements of NO(x) emissions and combustion efficiency for the hydrogen injectors at 2.540, 7.937, and 13.652 cm from the injector face. Results show that for some configurations, NO(x) emissions are comparable to that of state of the art Jet-A LDI combustor concepts.

Effects of excipients and curing process on the abuse deterrent properties of directly compressed tablets.

PubMed

Rahman, Ziyaur; Zidan, Ahmed S; Korang-Yeboah, Maxwell; Yang, Yang; Siddiqui, Akhtar; Shakleya, Diaa; Khan, Mansoor A; Cruz, Celia; Ashraf, Muhammad

2017-01-30

The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox™ based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size distribution following mechanical manipulation, drug extraction in water and alcohol, syringeability and injectability. Other non-ADPs such as surface morphology and tablet dissolution were also studied. It was found that presence of 50% or more of water soluble or swellable excipient in the ADF tablets significantly affected the tablet hardness, particle size distribution following mechanical manipulation and drug extraction while small amount (5%) of excipients had either minimal or no effect on ADPs of these tablets. Addition of high molecular weight HPMC (K 100M) affected syringeability and injectability of ADF. Curing process was found to affect ADPs (hardness, particle size distribution, drug extraction and syringeability and injectability) when compared with uncured tablet. In conclusion, addition of large amount of excipients, especially water soluble ones in Polyox™ based ADF tablets increase the risk of abuse by various routes of administration. Published by Elsevier B.V.

Rapid determination of piracetam in human plasma and cerebrospinal fluid by micellar electrokinetic chromatography with sample direct injection.

PubMed

Yeh, Hsin-Hua; Yang, Yuan-Han; Ko, Ju-Yun; Chen, Su-Hwei

2006-07-07

A simple micellar electrokinetic chromatography (MEKC) method with UV detection at 200 nm for analysis of piracetam in plasma and in cerebrospinal fluid (CSF) by direct injection without any sample pretreatment is described. The separation of piracetam from biological matrix was performed at 25 degrees C using a background electrolyte consisting of Tris buffer with sodium dodecyl sulfate (SDS) as the electrolyte solution. Several parameters affecting the separation of the drug from biological matrix were studied, including the pH and concentrations of the Tris buffer and SDS. Under optimal MEKC condition, good separation with high efficiency and short analyses time is achieved. Using imidazole as an internal standard (IS), the linear ranges of the method for the determination of piracetam in plasma and in CSF were all between 5 and 500 microg/mL; the detection limit of the drug in plasma and in CSF (signal-to-noise ratio=3; injection 0.5 psi, 5s) was 1.0 microg/mL. The applicability of the proposed method for determination of piracetam in plasma and CSF collected after intravenous administration of 3g piracetam every 6h and oral administration 1.2g every 6h in encephalopathy patients with aphasia was demonstrated.

Drug preparation, injection, and sharing practices in Tajikistan: a qualitative study in Kulob and Khorog.

PubMed

Otiashvili, David; Latypov, Alisher; Kirtadze, Irma; Ibragimov, Umedjon; Zule, William

2016-06-02

Sharing injection equipment remains an important rout of transmission of HIV and HCV infections in the region of Eastern Europe and Central Asia. Tajikistan is one of the most affected countries with high rates of injection drug use and related epidemics.The aim of this qualitative study was to describe drug use practices and related behaviors in two Tajik cities - Kulob and Khorog. Twelve focus group discussions (6 per city) with 100 people who inject drugs recruited through needle and syringe program (NSP) outreach in May 2014. Topics covered included specific drugs injected, drug prices and purity, access to sterile equipment, safe injection practices and types of syringes and needles used. Qualitative thematic analysis was performed using NVivo 10 software. All participants were male and ranged in age from 20 to 78 years. Thematic analysis showed that cheap Afghan heroin, often adulterated by dealers with other admixtures, was the only drug injected. Drug injectors often added Dimedrol (Diphenhydramine) to increase the potency of "low quality" heroin. NSPs were a major source of sterile equipment. Very few participants report direct sharing of needles and syringes. Conversely, many participants reported preparing drugs jointly and sharing injection paraphernalia. Using drugs in an outdoor setting and experiencing withdrawal were major contributors to sharing equipment, using non-sterile water, not boiling and not filtering the drug solution. Qualitative research can provide insights into risk behaviors that may be missed in quantitative studies. These finding have important implications for planning risk reduction interventions in Tajikistan. Prevention should specifically focus on indirect sharing practices.

Single-shot measurements of low emittance beams from laser-plasma accelerators comparing two triggered injection methods

NASA Astrophysics Data System (ADS)

van Tilborg, Jeroen

2017-10-01

The success of laser plasma accelerator (LPA) based applications, such as a compact x-ray free electron laser (FEL), relies on the ability to produce electron beams with excellent 6D brightness, where brightness is defined as the ratio of charge to the product of the three normalized emittances. As such, parametric studies of the emittance of LPA generated electron beams are essential. Profiting from a stable and tunable LPA setup, combined with a carefully designed single-shot energy-dispersed emittance diagnostic, we present a direct comparison of charge dependent emittance measurements of electron beams generated by two different injection mechanisms: ionization injection and shock-induced density down-ramp injection. Both injection mechanisms have gained in popularity in recent years due to their demonstrated stable LPA performance. For the down-ramp injection configuration, normalized emittances a factor of two lower were recorded: less than 1 micron at spectral charge densities up to 2 pC/MeV. For both injection mechanisms, a contributing correlation of space charge to the emittance was identified. This measurement technique in general, and these results specifically, are critical to the evaluation of LPA injection methods and development of high-quality LPA beam lines worldwide. This work is supported by the U.S. DOE under Contract No. DE-AC02-05CH11231, by the U.S. DOE NNSA, DNN R&D (NA22), by the National Science Foundation under Grant No. PHY-1415596, and by the Gordon and Betty Moore Foundation under Grant ID GBMF4898.

Coupled Mechanical and Thermal Modeling of Frictional Melt Injection to Constrain Physical Conditions of the Earthquake Source Region

NASA Astrophysics Data System (ADS)

Sawyer, W.; Resor, P. G.

2016-12-01

Pseudotachylyte, a fault rock formed through coseismic frictional melting, provides an important record of coseismic mechanics. In particular, injection veins formed at a high angle to the fault surface have been used to estimate rupture directivity, velocity, pulse length, stress and strength drop, as well as slip weakening distance and wall rock stiffness. These studies, however, have generally treated injection vein formation as a purely elastic process and have assumed that processes of melt generation, transport, and solidification have little influence on the final vein geometry. Using a modified analytical approximation of injection vein formation based on a dike intrusion model we find that the timescales of quenching and flow propagation are similar for a composite set of injection veins compiled from the Asbestos Mountain Fault, USA (Rowe et al., 2012), Gole Larghe Fault Zone, Italy (Griffith et al., 2012) and the Fort Foster Brittle Zone. This indicates a complex, dynamic process whose behavior is not fully captured by the current approach. To assess the applicability of the simplifying assumptions of the dike model when applied to injection veins we employ a finite-element time-dependent model of injection vein formation. This model couples elastic deformation of the wall rock with the fluid dynamics and heat transfer of the frictional melt. The final geometry of many injection veins is unaffected by the inclusion of these processes. However, some injection veins are found to be flow limited, with a final geometry reflecting cooling of the vein before it reaches an elastic equilibrium with the wall rock. In these cases, numerical results are significantly different from the dike model, and two basic assumptions of the dike model, self-similar growth and a uniform pressure gradient, are shown to be false. Additionally, we apply the finite-element model to provide two new constraints on the Fort Foster coseismic environment: a lower limit on the initial melt temperature of 1400 *C, and either significant coseismic wall rock softening or high transient tensile stress.

Autologous fat injection into the pectoralis major as an adjunct to surgical correction of gynecomastia.

PubMed

Pilanci, Ozgur; Basaran, Karaca; Aydin, Hasan Utkan; Cortuk, Oguz; Kuvat, Samet Vasfi

2015-03-01

Correction of gynecomastia in males is a frequently performed aesthetic procedure. Various surgical options involving the removal of excess skin, fat, or glandular tissue have been described. However, poor aesthetic outcomes, including a flat or depressed pectoral area, limit the success of these techniques. The authors sought to determine patient satisfaction with the results of upper chest augmentation by direct intrapectoral fat injection in conjunction with surgical correction of gynecomastia. In this prospective study, 26 patients underwent liposuction and glandular excision, glandular excision alone, or Benelli-type skin excision. All patients received intramuscular fat injections in predetermined zones of the pectoralis major (PM). The mean volume of fat injected was 160 mL (range, 80-220 mL per breast) bilaterally. Patients were monitored for an average of 16 months (range, 8-24 months). Hematoma formation and consequent infraareolar depression was noted in 1 patient and was corrected by secondary lipografting. Mean patient satisfaction was rated as 8.4 on a scale of 1 (unsatisfactory) to 10 (highly satisfactory). Autologous intrapectoral fat injection performed simultaneously with gynecomastia correction can produce a masculine appearance. The long-term viability of fat cells injected into the PM needs to be determined. 4 Therapeutic. © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.

Non-fatal overdose among adult prisoners with a history of injecting drug use in two Australian states.

PubMed

Moore, Elizabeth; Winter, Rebecca; Indig, Devon; Greenberg, David; Kinner, Stuart A

2013-11-01

Recently released prisoners are at markedly increased risk of death and drug-related causes predominate. Non-fatal overdose (NFOD) is considerably more common than fatal overdose, but has received relatively little research attention and most studies of NFOD in this population have suffered from small samples of unknown representativeness. This study aimed to estimate the prevalence and correlates of lifetime NFOD among prisoners in NSW and Queensland. Cross-sectional surveys of adult prisoners in two Australian states: New South Wales (n=972) and Queensland (n=1316). Use of similar measures and methods in the two states made direct comparison of findings possible. In both NSW and Queensland, 23% of participants reported a lifetime history of NFOD and prisoners with a history of injecting drug use were significantly more likely to report lifetime NFOD. The lifetime prevalence of NFOD among prisoners with a history of injecting drug use was significantly higher in NSW than in Queensland (44% vs. 35%; p<0.01). Independent correlates of lifetime NFOD were similar across the two states and included ever attempting suicide, ever injecting heroin, and ever injecting opioids. The risk of NFOD among prisoners with a history of injecting drug use is high. An understanding of the risk factors for NFOD in this population can inform targeted, evidence-based interventions to reduce this risk. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Injection locking of optomechanical oscillators via acoustic waves

NASA Astrophysics Data System (ADS)

Huang, Ke; Hossein-Zadeh, Mani

2018-04-01

Injection locking is a powerful technique for synchronization of oscillator networks and controlling the phase and frequency of individual oscillators using similar or other types of oscillators. Here, we present the first demonstration of injection locking of a radiation-pressure driven optomechanical oscillator (OMO) via acoustic waves. As opposed to previously reported techniques (based on pump modulation or direct application of a modulated electrostatic force), injection locking of OMO via acoustic waves does not require optical power modulation or physical contact with the OMO and it can easily be implemented on various platforms. Using this approach we have locked the phase and frequency of two distinct modes of a microtoroidal silica OMO to a piezoelectric transducer (PZT). We have characterized the behavior of the injection locked OMO with three acoustic excitation configurations and showed that even without proper acoustic impedance matching the OMO can be locked to the PZT and tuned over 17 kHz with only -30 dBm of RF power fed to the PZT. The high efficiency, simplicity and scalability of the proposed approach paves the road toward a new class of photonic systems that rely on synchronization of several OMOs to a single or multiple RF oscillators with applications in optical communication, metrology and sensing. Beyond its practical applications, injection locking via acoustic waves can be used in fundamental studies in quantum optomechanics where thermal and optical isolation of the OMO are critical.

Geophysical Methods, Tracer Leakage, and Flow Modeling Studies at the West Pearl Queen Carbon Sequestration/EOR Pilot Site

NASA Astrophysics Data System (ADS)

Bromhal, G. S.; Wilson, T. H.; Wells, A.; Diehl, R.; Smith, D. H.

2003-12-01

Recently, a few thousand tons of CO2 were injected into the West Pearl Queen field, a depleted oil reservoir in southeastern New Mexico, for a pilot carbon sequestration project. Small amounts of 3 different perfluorocarbon tracers were injected with the CO2. Approximately 50 capillary absorption tube samplers (CATS) were located across the field within 2m of the grounds surface to detect the tracers in extremely small (~10-13L) quantities. After only several days, the CATS detected quantities of tracers at distances of up to 350m from the injection well. Greater amounts of tracers were detected in the different directions. The underground transport mechanism(s) are uncertain; however, appearance of tracer in the CATS after only a 6 day period suggests that CO2 movement may have occurred through near-surface processes. Subsequent tracer measurements made over 10 and 54 day time periods revealed continued tracer leakage. To try to understand the tracer information, we conducted lineament interpretations of the area using a black and white aerial photo taken in 1949, digital orthophotos, and Landsat TM imagery. Lineament interpretations revealed distinct northeast and northwest trending lineament sets. These directions coincided roughly with the direction of tracer-leakage into areas northwest and southwest of the injection well. The near-surface geology consists of a few-feet thick veneer of late Pleistocene and Holocene sand dunes covering the middle Pleistocene Mescalero caliche. A survey of the caliche was made using ground penetrating radar (GPR) to attempt to identify any preferential migration pathways. Modeling studies also were performed to identify the potential leakage pathways at the site. Because of the relatively fast appearance of tracers at large distances from the injection well, simple diffusion through the surface layers was ruled out. Wind patterns in the area have also made transport through the atmosphere and back into the ground highly unlikely. Other potential leakage pathways were transport from the well through the saturated zone and diffusion into the unsaturated zone or combined pressure-driven and diffusive flow through the vadose zone. An analysis of these alternatives has been made for this study.

High fear of intra-oral injections: prevalence and relationship to dental fear and dental avoidance among 10- to 16-yr-old children.

PubMed

Berge, Karin G; Agdal, Maren L; Vika, Margrethe; Skeie, Marit S

2016-12-01

The present study aimed to: (i) estimate the prevalence of self-reported high fear of intra-oral injections, high blood-injury fear, and injection fear; (ii) explore the overlap between high fear of intra-oral injections and high fear of dental treatment; and (iii) evaluate the possible consequence of high fear of intra-oral injections in terms of avoidance of dental care. The sample included 1,441 subjects, 10- to 16-yr of age, attending elementary schools in a county of Norway. Data were collected using questionnaires that were completed in classrooms. The survey instruments used were the Intra-Oral Injection Fear-scale, the Children's Fear Survey Schedule-Dental Subscale, the Injection Phobia scale for children, and the Mutilation Questionnaire for children. In total, 13.9% of the children reported high intra-oral injection fear. A strong association was found between fear of intra-oral injections and dental fear. When an intra-oral injection was needed, 10.6% would avoid dental treatment. In multiple regression analysis, high intra-oral injection fear was found to be associated with avoidance of dental treatment (OR = 6.52; 95% CI: 3.99-10.67). It was concluded that high fear of intra-oral injections was prevalent and might lead to avoidance of necessary dental treatment. Hence, intra-oral injection fear should be addressed before treatment of dental fear. © 2016 Eur J Oral Sci.

Planar near-nozzle velocity measurements during a single high-pressure fuel injection

NASA Astrophysics Data System (ADS)

Schlüßler, Raimund; Gürtler, Johannes; Czarske, Jürgen; Fischer, Andreas

2015-09-01

In order to reduce the fuel consumption and exhaust emissions of modern Diesel engines, the high-pressure fuel injections have to be optimized. This requires continuous, time-resolved measurements of the fuel velocity distribution during multiple complete injection cycles, which can provide a deeper understanding of the injection process. However, fuel velocity measurements at high-pressure injection nozzles are a challenging task due to the high velocities of up to 300 m/s, the short injection durations in the range and the high fuel droplet density especially near the nozzle exit. In order to solve these challenges, a fast imaging Doppler global velocimeter with laser frequency modulation (2D-FM-DGV) incorporating a high-speed camera is presented. As a result, continuous planar velocity field measurements are performed with a measurement rate of 200 kHz in the near-nozzle region of a high-pressure Diesel injection. The injection system is operated under atmospheric surrounding conditions with injection pressures up to 1400 bar thereby reaching fuel velocities up to 380 m/s. The measurements over multiple entire injection cycles resolved the spatio-temporal fluctuations of the fuel velocity, which occur especially for low injection pressures. Furthermore, a sudden setback of the velocity at the beginning of the injection is identified for various injection pressures. In conclusion, the fast measurement system enables the investigation of the complete temporal behavior of single injection cycles or a series of it. Since this eliminates the necessity of phase-locked measurements, the proposed measurement approach provides new insights for the analysis of high-pressure injections regarding unsteady phenomena.

Optical gain in colloidal quantum dots achieved with direct-current electrical pumping

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, Jaehoon; Park, Young-Shin; Klimov, Victor Ivanovich

Chemically synthesized semiconductor quantum dots (QDs) can potentially enable solution-processable laser diodes with a wide range of operational wavelengths, yet demonstrations of lasing from the QDs are still at the laboratory stage. An important challenge—realization of lasing with electrical injection—remains unresolved, largely due to fast nonradiative Auger recombination of multicarrier states that represent gain-active species in the QDs. Here in this paper, we present population inversion and optical gain in colloidal nanocrystals realized with direct-current electrical pumping. Using continuously graded QDs, we achieve a considerable suppression of Auger decay such that it can be outpaced by electrical injection. Further, wemore » apply a special current-focusing device architecture, which allows us to produce high current densities (j) up to ~18 A cm -2 without damaging either the QDs or the injection layers. The quantitative analysis of electroluminescence and current-modulated transmission spectra indicates that with j = 3-4 A cm -2 we achieve the population inversion of the band-edge states.« less

Modeling the budget impact of long-acting injectable paliperidone palmitate in the treatment of schizophrenia in Japan

PubMed Central

Mahlich, Jörg; Nishi, Masamichi; Saito, Yoshimichi

2015-01-01

Background The cost of schizophrenia in Japan is high and new long-acting injectable (LAI) antipsychotics might be able to reduce costs by causing a reduction of hospital stays. We aim to estimate budget effects of the introduction of a new 1-month LAI, paliperidone palmitate, in Japan. Methods A budget impact analysis was conducted from a payer perspective. The model took direct costs of illness into account (ie, costs for inpatient and outpatient services, as well as drug costs). The robustness of the model was checked using a sensitivity analysis. Results According to our calculations, direct total costs of schizophrenia reach 710,500 million yen a year (US$6 billion). These costs decrease to 691,000 million yen (US$5.9 billion) 3 years after the introduction of paliperidone palmitate. Conclusion From a payer point of view, the introduction of a new treatment for schizophrenia in Japan helps to save resources and is not associated with a higher financial burden. PMID:26045674

Optical gain in colloidal quantum dots achieved with direct-current electrical pumping

DOE PAGES

Lim, Jaehoon; Park, Young-Shin; Klimov, Victor Ivanovich

2017-11-20

Chemically synthesized semiconductor quantum dots (QDs) can potentially enable solution-processable laser diodes with a wide range of operational wavelengths, yet demonstrations of lasing from the QDs are still at the laboratory stage. An important challenge—realization of lasing with electrical injection—remains unresolved, largely due to fast nonradiative Auger recombination of multicarrier states that represent gain-active species in the QDs. Here in this paper, we present population inversion and optical gain in colloidal nanocrystals realized with direct-current electrical pumping. Using continuously graded QDs, we achieve a considerable suppression of Auger decay such that it can be outpaced by electrical injection. Further, wemore » apply a special current-focusing device architecture, which allows us to produce high current densities (j) up to ~18 A cm -2 without damaging either the QDs or the injection layers. The quantitative analysis of electroluminescence and current-modulated transmission spectra indicates that with j = 3-4 A cm -2 we achieve the population inversion of the band-edge states.« less

Microfluidic direct injection method for analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) using molecularly imprinted polymers coupled on-line with LC-MS/MS.

PubMed

Shah, Kumar A; Peoples, Michael C; Halquist, Matthew S; Rutan, Sarah C; Karnes, H Thomas

2011-01-25

The work described in this paper involves development of a high-throughput on-line microfluidic sample extraction method using capillary micro-columns packed with MIP beads coupled with tandem mass spectrometry for the analysis of urinary NNAL. The method was optimized and matrix effects were evaluated and resolved. The method enabled low sample volume (200 μL) and rapid analysis of urinary NNAL by direct injection onto the microfluidic column packed with molecularly imprinted beads engineered to NNAL. The method was validated according to the FDA bioanalytical method validation guidance. The dynamic range extended from 20.0 to 2500.0 pg/mL with a percent relative error of ±5.9% and a run time of 7.00 min. The lower limit of quantitation was 20.0 pg/mL. The method was used for the analysis of NNAL and NNAL-Gluc concentrations in smokers' urine. Copyright © 2010 Elsevier B.V. All rights reserved.

Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System.

PubMed

Cai, Xiang; Walgenbach, Martin; Doerpmond, Malte; Schulze Lammers, Peter; Sun, Yurui

2016-01-20

To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input-output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy.

Pilot-Scale Demonstration of In-Situ Chemical Oxidation ...

EPA Pesticide Factsheets

A pilot-scale in situ chemical oxidation (ISCO) demonstration, involving subsurface injections of sodium permanganate (NaMnO4), was performed at the US Marine Corp Recruit Depot (MCRD), site 45 (Parris Island (PI), SC). The ground water was originally contaminated with perchloroethylene (PCE) (also known as tetrachloroethylene), a chlorinated solvent used in dry cleaner operations. High resolution site characterization involved multiple iterations of soil core sampling and analysis. Nested micro-wells and conventional wells were also used to sample and analyze ground water for PCE and decomposition products (i.e., trichloroethyelene (TCE), dichloroethylene (c-DCE, t-DCE), and vinyl chloride (VC)), collectively referred to as chlorinated volatile organic compounds (CVOC). This characterization methodology was used to develop and refine the conceptual site model and the ISCO design, not only by identifying CVOC contamination but also by eliminating uncontaminated portions of the aquifer from further ISCO consideration. Direct-push injection was selected as the main method of NaMnO4 delivery due to its flexibility and low initial capital cost. Site impediments to ISCO activities in the source area involved subsurface utilities, including a high pressure water main, a high voltage power line, a communication line, and sanitary and stormwater sewer lines. Utility markings were used in conjunction with careful planning and judicious selection of injection locations. A

New steady-state quiescent high-confinement plasma in an experimental advanced superconducting tokamak.

PubMed

Hu, J S; Sun, Z; Guo, H Y; Li, J G; Wan, B N; Wang, H Q; Ding, S Y; Xu, G S; Liang, Y F; Mansfield, D K; Maingi, R; Zou, X L; Wang, L; Ren, J; Zuo, G Z; Zhang, L; Duan, Y M; Shi, T H; Hu, L Q

2015-02-06

A critical challenge facing the basic long-pulse high-confinement operation scenario (H mode) for ITER is to control a magnetohydrodynamic (MHD) instability, known as the edge localized mode (ELM), which leads to cyclical high peak heat and particle fluxes at the plasma facing components. A breakthrough is made in the Experimental Advanced Superconducting Tokamak in achieving a new steady-state H mode without the presence of ELMs for a duration exceeding hundreds of energy confinement times, by using a novel technique of continuous real-time injection of a lithium (Li) aerosol into the edge plasma. The steady-state ELM-free H mode is accompanied by a strong edge coherent MHD mode (ECM) at a frequency of 35-40 kHz with a poloidal wavelength of 10.2 cm in the ion diamagnetic drift direction, providing continuous heat and particle exhaust, thus preventing the transient heat deposition on plasma facing components and impurity accumulation in the confined plasma. It is truly remarkable that Li injection appears to promote the growth of the ECM, owing to the increase in Li concentration and hence collisionality at the edge, as predicted by GYRO simulations. This new steady-state ELM-free H-mode regime, enabled by real-time Li injection, may open a new avenue for next-step fusion development.

Electroforming of optical tooling in high-strength Ni-Co alloy

NASA Astrophysics Data System (ADS)

Stein, Berl

2003-05-01

Plastic optics are often mass produced by injection, compression or injection-compression molding. Optical quality molds can be directly machined in appropriate materials (tool steels, electroless nickel, aluminum, etc.), but much greater cost efficiency can be achieved with electroformed modl inserts. Traditionally, electroforming of optical quality mold inserts has been carried out in nickel, a material much softer than tool steels which, when hardened to 45 - 50 HRc usually exhibit high wear resistance and long service life (hundreds of thousands of impressions per mold). Because of their low hardness (< 20 HRc), nickel molds can produce only tens of thousands of parts before they are scrapped due to wear or accidental damage. This drawback prevented their wider usage in general plastic and optical mold making. Recently, NiCoForm has developed a proprietary Ni-CO electroforming bath combining the high strength and wear resistance of the alloy with the low stress and high replication fidelity typical of pure nickel electroforming. This paper will outline the approach to electroforming of optical quality tooling in low stress, high strength Ni-Co alloy and present several examples of electroformed NiColoy mold inserts.

The Northwest Geysers EGS Demonstration Project, California. Pre-stimulation Modeling and Interpretation of the Stimulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutqvist, Jonny; Dobson, Patrick F.; Garcia, Julio

The Northwest Geysers Enhanced Geothermal System (EGS) demonstration project aims to create an EGS by directly and systematically injecting cool water at relatively low pressure into a known High Temperature (280–400 °C) Zone (HTZ) located under the conventional (240 °C) geothermal steam reservoir at The Geysers geothermal field in California. Here we report that , the results of coupled thermal, hydraulic, and mechanical (THM) analyses made using a model developed as part of the pre-stimulation phase of the EGS demonstration project is presented. The model simulations were conducted in order to investigate injection strategies and the resulting effects of cold-watermore » injection upon the EGS system; in particular to predict the extent of the stimulation zone for a given injection schedule. The actual injection began on October 6, 2011, and in this paper a comparison of pre-stimulation model predictions with micro-earthquake (MEQ) monitoring data over the first few months of a one-year injection program is presented. The results show that, by using a calibrated THM model based on historic injection and MEQ data at a nearby well, the predicted extent of the stimulation zone (defined as a zone of high MEQ density around the injection well) compares well with observed seismicity. The modeling indicates that the MEQ events are related to shear reactivation of preexisting fractures, which is triggered by the combined effects of injection-induced cooling around the injection well and small changes in steam pressure as far as half a kilometer away from the injection well. Pressure-monitoring data at adjacent wells and satellite-based ground-surface deformation data were also used to validate and further calibrate reservoir-scale hydraulic and mechanical model properties. The pressure signature monitored from the start of the injection was particularly useful for a precise back-calculation of reservoir porosity. Ultimately, the first few months of reservoir pressure and surface deformation data were useful for estimating the reservoir-rock permeability and elastic modulus. Finally, although the extent of the calculated stimulation zone matches the field observations over the first few months of injection, the observed surface deformations and MEQ evolution showed more heterogeneous behavior as a result of more complex geology, including minor faults and fracture zones that are important for consideration in the analysis of energy production and the long-term evolution of the EGS system.« less

The Northwest Geysers EGS Demonstration Project, California. Pre-stimulation Modeling and Interpretation of the Stimulation

DOE PAGES

Rutqvist, Jonny; Dobson, Patrick F.; Garcia, Julio; ...

2013-10-17

The Northwest Geysers Enhanced Geothermal System (EGS) demonstration project aims to create an EGS by directly and systematically injecting cool water at relatively low pressure into a known High Temperature (280–400 °C) Zone (HTZ) located under the conventional (240 °C) geothermal steam reservoir at The Geysers geothermal field in California. Here we report that , the results of coupled thermal, hydraulic, and mechanical (THM) analyses made using a model developed as part of the pre-stimulation phase of the EGS demonstration project is presented. The model simulations were conducted in order to investigate injection strategies and the resulting effects of cold-watermore » injection upon the EGS system; in particular to predict the extent of the stimulation zone for a given injection schedule. The actual injection began on October 6, 2011, and in this paper a comparison of pre-stimulation model predictions with micro-earthquake (MEQ) monitoring data over the first few months of a one-year injection program is presented. The results show that, by using a calibrated THM model based on historic injection and MEQ data at a nearby well, the predicted extent of the stimulation zone (defined as a zone of high MEQ density around the injection well) compares well with observed seismicity. The modeling indicates that the MEQ events are related to shear reactivation of preexisting fractures, which is triggered by the combined effects of injection-induced cooling around the injection well and small changes in steam pressure as far as half a kilometer away from the injection well. Pressure-monitoring data at adjacent wells and satellite-based ground-surface deformation data were also used to validate and further calibrate reservoir-scale hydraulic and mechanical model properties. The pressure signature monitored from the start of the injection was particularly useful for a precise back-calculation of reservoir porosity. Ultimately, the first few months of reservoir pressure and surface deformation data were useful for estimating the reservoir-rock permeability and elastic modulus. Finally, although the extent of the calculated stimulation zone matches the field observations over the first few months of injection, the observed surface deformations and MEQ evolution showed more heterogeneous behavior as a result of more complex geology, including minor faults and fracture zones that are important for consideration in the analysis of energy production and the long-term evolution of the EGS system.« less

UHPLC-Q-TOF-MS-based metabolomics approach to compare the saponin compositions of Xueshuantong injection and Xuesaitong injection.

PubMed

Yao, Changliang; Yang, Wenzhi; Zhang, Jingxian; Qiu, Shi; Chen, Ming; Shi, Xiaojian; Pan, Huiqin; Wu, Wanying; Guo, Dean

2017-02-01

Various traditional Chinese medicine preparations developed from Notoginseng total saponins, including Xueshuantong injection and Xuesaitong injection, are extensively used in China to treat cardiocerebrovascular diseases. However, the difference of their saponin compositions remains unknown. An ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry based metabolomics approach was developed to probe the saponin discrimination between Xueshuantong and Xuesaitong and the related factors by large sample analysis. A highly efficient chromatographic separation was achieved on an HSS T3 column within 20 min with the holistic metabolites information recorded in the negative MS E mode. A six-step data pretreatment procedure mainly based on Progenesis QI and mass defect filtering was established. Pattern recognition chemometrics was used to discover the potential saponin markers. The saponin composition of Wuzhou Xueshuantong showed distinct discrimination from the other products. Wuzhou Xueshuantong contains more abundant protopanaxatriol-type noto-R 1 , Rg 1 , Re, and protopanaxadiol-type Rb 1 , but less Rd and other low-polarity protopanaxadiol-type ginsenosides. These differences could not directly correlate to the use of different parts of Panax notoginseng, but possibly to the different preparation techniques employed by different manufacturers. These results are beneficial to the establishment of pharmacopoeia standards and the assessment of the efficacy and adverse drug reactions for these homologous products. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation of Flow-Injection Tandem Mass Spectrometry for Rapid and High-Throughput Quantitative Determination of B-Vitamins in Nutritional Supplements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhandari, Deepak; Van Berkel, Gary J

2012-01-01

The use of flow-injection electrospray ionization tandem mass spectrometry for rapid and high-throughput mass spectral analysis of selected B-vitamins, viz. B1, B2, B3, B5, and B6, in nutritional formulations was demonstrated. A simple and rapid (~5 min) in-tube sample preparation was performed by adding extraction solvent to a powdered sample aliquot followed by agitation, centrifugation, and filtration to recover an extract for analysis. Automated flow injection introduced 1 L of the extracts directly into the mass spectrometer ion source without chromatographic separation. Sample-to-sample analysis time was 60 s representing significant improvement over conventional liquid chromatography approaches which typically require 25-45more » min, and often require more significant sample preparation procedures. Quantitative capabilities of the flow-injection analysis were tested using the method of standard additions and NIST standard reference material (SRM 3280) multivitamin/multielement tablets. The quantity determined for each B-vitamin in SRM 3280 was within the statistical range provided for the respective certified values. The same sample preparation and analysis approach was also applied to two different commercial vitamin supplement tablets and proved to be successful in the quantification of the selected B-vitamins as evidenced by an agreement with the labels values and the results obtained using isotope dilution liquid chromatography/mass spectrometry.« less

Method for the quantification of vanadyl porphyrins in fractions of crude oils by High Performance Liquid Chromatography-Flow Injection-Inductively Coupled Plasma Mass Spectrometry

NASA Astrophysics Data System (ADS)

Wandekoken, Flávia G.; Duyck, Christiane B.; Fonseca, Teresa C. O.; Saint'Pierre, Tatiana D.

2016-05-01

High performance liquid chromatography hyphenated by flow injection to inductively coupled plasma mass spectrometry (HPLC-FI-ICP-MS) was used to investigate V linked to porphyrins present in fractions of crude oil. First, the crude oil sample was submitted to fractionation by preparative liquid chromatography with UV detection, at the porphyrin Soret band wavelength (400 nm). The obtained porphyrin fractions were then separated in a 250 mm single column, in the HPLC, and eluted with different mobile phases (methanol or methanol:toluene (80:20; v:v)). The quantification of V-porphyrins in the fractions eluted from HPLC was carried out by online measuring the 51V isotope in the ICP-MS, against vanadyl octaethylporphine standard solutions (VO-OEP), prepared in the same solvent as the mobile phase, and injected post-column directly into the plasma. A 20 μg L- 1 Ge in methanol was used as internal standard for minimizing non-spectral interference, such as short-term variations due to injection. The mathematical treatment of the signal based on Fast Fourier Transform smoothing algorithm was employed to improve the precision. The concentrations of V as V-porphyrins were between 2.7 and 11 mg kg- 1 in the fractions, which were close to the total concentration of V in the porphyrin fractions of the studied crude oil.

Characteristics of Seismicity at Ngatamariki and Rotokawa Geothermal Fields, North Island, New Zealand

NASA Astrophysics Data System (ADS)

Hopp, C. J.; Mroczek, S.; Savage, M. K.; Sewell, S. M.; Townend, J.; Sherburn, S.

2017-12-01

Fluid-induced seismicity (FIS) is a useful indicator of thermal and pressure changes within a geothermal reservoir. Given the difficulty of making measurements in the space between wells, FIS provides one of the only direct observations of fluid-related reservoir processes. Understanding exactly why and how these microearthquakes occur helps us unravel the interaction between the movement of fluid and heat at depth and could allow for a better understanding of the creation and destruction of permeability in the reservoir. We begin with an earthquake catalog of roughly 6200 events which occurred between May 2012 and November 2015 at the Mercury geothermal fields at Rotokawa and Ngatamariki. We expand this catalog using matched filter detection to include 350,000 microearthquakes. Earthquakes at the fields are densely clustered in areas of active fluid injection and the rate of seismicity is highly correlated with injection rate. We present high-precision locations as well as frequency-magnitude distributions and source mechanisms for significant events and discuss their relation to injection and production rates at the fields. In particular, we focus on specific periods of interest including the stimulation of well NM08 in June 2012, the Ngatamariki plant startup in April 2013, the switch of injection at Rotokawa to well RK22 in 2013 and a prolonged period of permeability change at well RK24.

Patient's Compliance on the Use of Extended Low Molecular Weight Heparin Post Major Pelvic Surgeries in Cancer Patients at King Hussein Cancer Center.

PubMed

Baba, M; Al-Masri, M; Salhab, M; El-Ghanem, M

2015-01-01

Effective Venous Thrombo-Embolism (VTE) prophylaxis is used in less than 50% of oncology patients despite its wide availability. Low molecular weight heparin (LMWH) as a daily injection is an essential tool for effective prophylaxis against deep vein thrombosis (DVT). Daily outpatient self-injection by the patients or their family members is common practice. The effectiveness of this measure depends on patient compliance. The purpose of this study is to determine the degree of compliance and the factors that affect compliance to the extended out-patient use of prophylactic LMWH for 1 month after major abdominal/pelvic surgeries in cancer patients at King Hussein Cancer Center (KHCC). Following major abdominal/pelvic surgeries, data on 160 cancer patients at KHCC from January 2007 until July 2012 were collected concerning knowledge of DVT and compliance with prophylactic self-injections by answering a questionnaire. We have achieved a high compliance rate, this was explained by the medical team's role in educating the patients about the risk of VTE and the importance of thromboprophylaxis. The compliance with self-injections was directly associated with younger age, employment and higher degree of education. The high compliance rate outside clinical trials can be achieved through comprehensive patient education by a well-qualified medical team, clarification of the importance of DVT prophylaxis and patients' support.

High-pressure injection injuries to the upper extremity: a review of the literature.

PubMed

Hogan, Christopher J; Ruland, Robert T

2006-07-01

The purpose of this review was to identify the relative impact of injected material, location of injury, time to debridement, injection pressure, infection, and the use of adjuvant steroid medication upon the need for amputation after high-pressure injection injuries to the upper extremity. A Medline literature search extending from 1966 to December 2003 was performed, referencing the key words "high-pressure injection injury," "grease gun injury," "paint gun injury," "pressure gun injury," and "high-pressure injection." The results were limited to the English language and to reports involving human subjects. Each abstract was reviewed to confirm that the described injury had occurred in the upper extremity and that it had truly been a high-pressure injection. The reference pages from each of the papers were reviewed to identify additional reports of high-pressure injection injury. Manuscripts describing injuries resulting from hand held syringes or other low-pressure mechanisms were excluded. All of the manuscripts were analyzed to identify the clinical outcome, age, hand dominance, site of injection, substance injected, injection pressure, elapsed time to wide debridement, use of steroids, and incidence of infection. These variables were subjected to a Pearson chi test to determine their impact upon the need for amputation. Four hundred thirty-five cases of high-pressure injection injury to the upper extremity were identified. The amputation rate after these injuries was 30%. The location of the injury and the material injected contributed significantly to the need for amputation. For injections of paint, paint thinner, gasoline, oil, or jet fuel (organic solvents), the amputation risk was lower if wide surgical debridement occurred within 6 hours of injury. Steroids did not impact the amputation rate or incidence of infection. The presence of infection did not affect the incidence of amputation. The risk of amputation after high-pressure injection injury to the upper extremity is highest with organic solvent injection into the fingers. Injections into the thumb or palm result in a much lower frequency of tissue loss. Emergent surgical debridement reduces the amputation risk after injections of organic solvents. From the available data, no conclusions could be reached regarding functional outcomes, other than amputation, after high-pressure injection injury.

Devascularization of Head and Neck Paragangliomas by Direct Percutaneous Embolization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozyer, Umut, E-mail: umut_ozyer@yahoo.com; Harman, Ali; Yildirim, Erkan

2010-10-15

Preoperative transarterial embolization of head and neck paragangliomas using particulate agents has proven beneficial for decreasing intraoperative blood loss. However, the procedure is often incomplete owing to extensive vascular structure and arteriovenous shunts. We report our experience with embolization of these lesions by means of direct puncture and intratumoral injection of n-butyl cyanoacrylate (NBCA) or Onyx. Ten patients aged 32-82 years who were referred for preoperative embolization of seven carotid body tumors and three jugular paragangliomas were retrospectively analyzed. Intratumoral injections were primarily performed in four cases with multiple small-caliber arterial feeders and adjunctive to transarterial embolization in six casesmore » with incomplete devascularization. Punctures were performed under ultrasound and injections were performed under roadmap fluoroscopic guidance. Detailed angiographies were performed before and after embolization procedures. Control angiograms showed complete or near-complete devascularization in all tumors. Three tumors with multiple small-caliber arterial feeders were treated with primary NBCA injections. One tumor necessitated transarterial embolization after primary injection of Onyx. Six tumors showed regional vascularization from the vasa vasorum or small-caliber branches of the external carotid artery following the transarterial approach. These regions were embolized with NBCA injections. No technical or clinical complications related to embolization procedures occurred. All except one of the tumors were surgically removed following embolization. In conclusion, preoperative devascularization with percutaneous direct injection of NBCA or Onyx is feasible, safe, and effective in head and neck paragangliomas with multiple small-caliber arterial feeders and in cases of incomplete devascularization following transarterial embolization.« less

Effects of arginine-glycine-aspartic acid peptide-conjugated quantum dots-induced photodynamic therapy on pancreatic carcinoma in vivo.

PubMed

Li, Ming-Ming; Cao, Jia; Yang, Jia-Chun; Shen, Yu-Jie; Cai, Xiao-Lei; Chen, Yuan-Wen; Qu, Chun-Ying; Zhang, Yi; Shen, Feng; Xu, Lei-Ming

2017-01-01

Quantum dots (QDs) conjugated with integrin antagonist arginine-glycine-aspartic acid (RGD) peptides (QDs-RGD) are novel nanomaterials with a unique optical property: a high molar extinction coefficient. Previously, we have shown that QDs-RGD demonstrate a photodynamic therapy (PDT) effect as new photosensitizers for the pancreatic cancer cell line SW1990 in vitro. Here, we investigate the application of QDs-RGD in mice bearing pancreatic tumors using PDT. To ensure that more photosensitizers accumulated in tumors, QDs-RGD were injected intratumorally. After selection of an adequate dosage for injection from analyses of biodistribution images captured by an IVIS system, PDT was initiated. Three groups were created according to different PDT procedures. In group 1, mice were injected with QDs-RGD intratumorally, and an optical fiber connected to a laser light was inserted directly into the tumor. Irradiation was sustained for 20 min with a laser light (630 nm) at 100 mW/cm 2 . In group 2, the laser optical fiber was placed around, and not inserted into, tumors. In group 3, PDT was conducted as in group 1 but without injection of QDs-RGD. After 28 days of observation, tumors on the back of mice in group 1 grew slowly (V/V 0 =3.24±0.70) compared with the control groups, whose tumors grew quickly, and the mean V/V 0 reached 6.08±0.50 (group 2) and 7.25±0.82 (group 3). Histology of tumor tissues showed more necrotic tissues, more inflammatory cells, and less vascular tissue in the PDT group than those in the control groups. These results suggest that QDs-RGD-mediated PDT, with illumination using an optical fiber inserted directly into the tumor, can inhibit the growth of SW1990 tumors with high efficiency in nude mice.

Adeno-Associated Virus Serotypes 1, 8, and 9 Share Conserved Mechanisms for Anterograde and Retrograde Axonal Transport

PubMed Central

Castle, Michael J.; Gershenson, Zachary T.; Giles, April R.; Holzbaur, Erika L.F.

2014-01-01

Abstract Adeno-associated virus (AAV) vectors often undergo long-distance axonal transport after brain injection. This leads to transduction of brain regions distal to the injection site, although the extent of axonal transport and distal transduction varies widely among AAV serotypes. The mechanisms driving this variability are poorly understood. This is a critical problem for applications that require focal gene expression within a specific brain region, and also impedes the utilization of vector transport for applications requiring widespread delivery of transgene to the brain. Here, we compared AAV serotypes 1 and 9, which frequently demonstrate distal transduction, with serotype 8, which rarely spreads beyond the injection site. To examine directional AAV transport in vitro, we used a microfluidic chamber to apply dye-labeled AAV to the axon termini or to the cell bodies of primary rat embryonic cortical neurons. All three serotypes were actively transported along axons, with transport characterized by high velocities and prolonged runs in both the anterograde and retrograde directions. Coinfection with pairs of serotypes indicated that AAV1, 8, and 9 share the same intracellular compartments for axonal transport. In vivo, both AAV8 and 9 demonstrated anterograde and retrograde transport within a nonreciprocal circuit after injection into adult mouse brain, with highly similar distributions of distal transduction. However, in mass-cultured neurons, we found that AAV1 was more frequently transported than AAV8 or 9, and that the frequency of AAV9 transport could be enhanced by increasing receptor availability. Thus, while these serotypes share conserved mechanisms for axonal transport both in vitro and in vivo, the frequency of transport can vary among serotypes, and axonal transport can be markedly increased by enhancing vector uptake. This suggests that variability in distal transduction in vivo likely results from differential uptake at the plasma membrane, rather than fundamental differences in transport mechanisms among AAV serotypes. PMID:24694006

Blindness following cosmetic injections of the face.

PubMed

Lazzeri, Davide; Agostini, Tommaso; Figus, Michele; Nardi, Marco; Pantaloni, Marcello; Lazzeri, Stefano

2012-04-01

Complications following facial cosmetic injections have recently heightened awareness of the possibility of iatrogenic blindness. The authors conducted a systematic review of the available literature to provide the best evidence for the prevention and treatment of this serious eye injury. The authors included in the study only the cases in which blindness was a direct consequence of a cosmetic injection procedure of the face. Twenty-nine articles describing 32 patients were identified. In 15 patients, blindness occurred after injections of adipose tissue; in the other 17, it followed injections of various materials, including corticosteroids, paraffin, silicone oil, bovine collagen, polymethylmethacrylate, hyaluronic acid, and calcium hydroxyapatite. Some precautions may minimize the risk of embolization of filler into the ophthalmic artery following facial cosmetic injections. Intravascular placement of the needle or cannula should be demonstrated by aspiration before injection and should be further prevented by application of local vasoconstrictor. Needles, syringes, and cannulas of small size should be preferred to larger ones and be replaced with blunt flexible needles and microcannulas when possible. Low-pressure injections with the release of the least amount of substance possible should be considered safer than bolus injections. The total volume of filler injected during the entire treatment session should be limited, and injections into pretraumatized tissues should be avoided. Actually, no safe, feasible, and reliable treatment exists for iatrogenic retinal embolism. Nonetheless, therapy should theoretically be directed to lowering intraocular pressure to dislodge the embolus into more peripheral vessels of the retinal circulation, increasing retinal perfusion and oxygen delivery to hypoxic tissues. Risk, V.

High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform.

PubMed

Abalde-Cela, Sara; Gould, Anna; Liu, Xin; Kazamia, Elena; Smith, Alison G; Abell, Chris

2015-05-06

Ethanol production by microorganisms is an important renewable energy source. Most processes involve fermentation of sugars from plant feedstock, but there is increasing interest in direct ethanol production by photosynthetic organisms. To facilitate this, a high-throughput screening technique for the detection of ethanol is required. Here, a method for the quantitative detection of ethanol in a microdroplet-based platform is described that can be used for screening cyanobacterial strains to identify those with the highest ethanol productivity levels. The detection of ethanol by enzymatic assay was optimized both in bulk and in microdroplets. In parallel, the encapsulation of engineered ethanol-producing cyanobacteria in microdroplets and their growth dynamics in microdroplet reservoirs were demonstrated. The combination of modular microdroplet operations including droplet generation for cyanobacteria encapsulation, droplet re-injection and pico-injection, and laser-induced fluorescence, were used to create this new platform to screen genetically engineered strains of cyanobacteria with different levels of ethanol production.

[Could it be a little less? Let the dose of thiopental in euthanasia depend on the body weight].

PubMed

Sprij, Bram

2010-01-01

The Dutch 'euthanasia and assisted suicide' practice guideline advises using 2000 mg thiopental to induce coma, followed by a muscle relaxant to cause death by respiratory paralysis. However, when a doctor administers such a high dose of thiopental as a bolus injection to a cachectic patient, there is a high likelihood of immediate death and other side effects, which can be distressing for the family. Doctors who administered less than 2000 mg have been reprimanded for not working according to current standards. Arguments are given concerning in which circumstances it is reasonable to use the advised dose of 2000 mg of thiopental and when to use less thiopental to induce coma by direct intravenous injection. The author suggests that it may be better to adjust the dose of thiopental according to the body weight of the patient. The current practice guideline needs revision.

Parametric emittance measurements of electron beams produced by a laser plasma accelerator

NASA Astrophysics Data System (ADS)

Barber, S. K.; van Tilborg, J.; Schroeder, C. B.; Lehe, R.; Tsai, H.-E.; Swanson, K. K.; Steinke, S.; Nakamura, K.; Geddes, C. G. R.; Benedetti, C.; Esarey, E.; Leemans, W. P.

2018-05-01

Laser plasma accelerators (LPA) offer an exciting possibility to deliver high energy, high brightness electrons beams in drastically smaller distance scales than is typical for conventional accelerators. As such, LPAs draw considerable attention as potential drivers for next generation light sources and for a compact linear collider. In order to asses the viability of an LPA source for a particular application, the brightness of the source should be properly characterized. In this paper, we present charge dependent transverse emittance measurements of LPA sources using both ionization injection and shock induced density down ramp injection, with the latter delivering smaller transverse emittances by a factor of two when controlling for charge density. The single shot emittance method is described in detail with a discussion on limitations related to second order transport effects. The direct role of space charge is explored through a series of simulations and found to be consistent with experimental observations.

The investigation of soot and temperature distributions in a visualized direct injection diesel engine using laser diagnostics

NASA Astrophysics Data System (ADS)

Han, Yong-taek; Kim, Ki-bum; Lee, Ki-hyung

2008-11-01

Based upon the method of temperature calibration using the diffusion flame, the temperature and soot concentrations of the turbulent flame in a visualized diesel engine were qualitatively measured. Two different cylinder heads were used to investigate the effect of swirl ratio within the combustion chamber. From this experiment, we find that the highest flame temperature of the non-swirl head engine is approximately 2400 K and that of the swirl head engine is 2100 K. In addition, as the pressure of fuel injection increases, the in-cylinder temperature increases due to the improved combustion of a diesel engine. This experiment represented the soot quantity in the KL factor and revealed that the KL factor was high when the fuel collided with the cylinder wall. Moreover, the KL factor was also high in the area of the chamber where the temperature dropped rapidly.

New technologies for HWIL testing of WFOV, large-format FPA sensor systems

NASA Astrophysics Data System (ADS)

Fink, Christopher

2016-05-01

Advancements in FPA density and associated wide-field-of-view infrared sensors (>=4000x4000 detectors) have outpaced the current-art HWIL technology. Whether testing in optical projection or digital signal injection modes, current-art technologies for infrared scene projection, digital injection interfaces, and scene generation systems simply lack the required resolution and bandwidth. For example, the L3 Cincinnati Electronics ultra-high resolution MWIR Camera deployed in some UAV reconnaissance systems features 16MP resolution at 60Hz, while the current upper limit of IR emitter arrays is ~1MP, and single-channel dual-link DVI throughput of COTs graphics cards is limited to 2560x1580 pixels at 60Hz. Moreover, there are significant challenges in real-time, closed-loop, physics-based IR scene generation for large format FPAs, including the size and spatial detail required for very large area terrains, and multi - channel low-latency synchronization to achieve the required bandwidth. In this paper, the author's team presents some of their ongoing research and technical approaches toward HWIL testing of large-format FPAs with wide-FOV optics. One approach presented is a hybrid projection/injection design, where digital signal injection is used to augment the resolution of current-art IRSPs, utilizing a multi-channel, high-fidelity physics-based IR scene simulator in conjunction with a novel image composition hardware unit, to allow projection in the foveal region of the sensor, while non-foveal regions of the sensor array are simultaneously stimulated via direct injection into the post-detector electronics.

Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography

DOEpatents

Ferrieri, Richard A.; Schlyer, David J.; Alexoff, David

1996-01-09

A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.

Nonlinear dynamics of solitary and optically injected two-element laser arrays with four different waveguide structures: a numerical study.

PubMed

Li, Nianqiang; Susanto, H; Cemlyn, B R; Henning, I D; Adams, M J

2018-02-19

We study the nonlinear dynamics of solitary and optically injected two-element laser arrays with a range of waveguide structures. The analysis is performed with a detailed direct numerical simulation, where high-resolution dynamic maps are generated to identify regions of dynamic instability in the parameter space of interest. Our combined one- and two-parameter bifurcation analysis uncovers globally diverse dynamical regimes (steady-state, oscillation, and chaos) in the solitary laser arrays, which are greatly influenced by static design waveguiding structures, the amplitude-phase coupling factor of the electric field, i.e. the linewidth-enhancement factor, as well as the control parameter, e.g. the pump rate. When external optical injection is introduced to one element of the arrays, we show that the whole system can be either injection-locked simultaneously or display rich, different dynamics outside the locking region. The effect of optical injection is to significantly modify the nature and the regions of nonlinear dynamics from those found in the solitary case. We also show similarities and differences (asymmetry) between the oscillation amplitude of the two elements of the array in specific well-defined regions, which hold for all the waveguiding structures considered. Our findings pave the way to a better understanding of dynamic instability in large arrays of lasers.

A novel crystallization method for visualizing the membrane localization of potassium channels.

PubMed Central

Lopatin, A N; Makhina, E N; Nichols, C G

1998-01-01

The high permeability of K+ channels to monovalent thallium (Tl+) ions and the low solubility of thallium bromide salt were used to develop a simple yet very sensitive approach to the study of membrane localization of potassium channels. K+ channels (Kir1.1, Kir2.1, Kir2.3, Kv2.1), were expressed in Xenopus oocytes and loaded with Br ions by microinjection. Oocytes were then exposed to extracellular thallium. Under conditions favoring influx of Tl+ ions (negative membrane potential under voltage clamp, or high concentration of extracellular Tl+), crystals of TlBr, visible under low-power microscopy, formed under the membrane in places of high density of K+ channels. Crystals were not formed in uninjected oocytes, but were formed in oocytes expressing as little as 5 microS K+ conductance. The number of observed crystals was much lower than the estimated number of functional channels. Based on the pattern of crystal formation, K+ channels appear to be expressed mostly around the point of cRNA injection when injected either into the animal or vegetal hemisphere. In addition to this pseudopolarized distribution of K+ channels due to localized microinjection of cRNA, a naturally polarized (animal/vegetal side) distribution of K+ channels was also frequently observed when K+ channel cRNA was injected at the equator. A second novel "agarose-hemiclamp" technique was developed to permit direct measurements of K+ currents from different hemispheres of oocytes under two-microelectrode voltage clamp. This technique, together with direct patch-clamping of patches of membrane in regions of high crystal density, confirmed that the localization of TlBr crystals corresponded to the localization of functional K+ channels and suggested a clustered organization of functional channels. With appropriate permeant ion/counterion pairs, this approach may be applicable to the visualization of the membrane distribution of any functional ion channel. PMID:9591643

A novel crystallization method for visualizing the membrane localization of potassium channels.

PubMed

Lopatin, A N; Makhina, E N; Nichols, C G

1998-05-01

The high permeability of K+ channels to monovalent thallium (Tl+) ions and the low solubility of thallium bromide salt were used to develop a simple yet very sensitive approach to the study of membrane localization of potassium channels. K+ channels (Kir1.1, Kir2.1, Kir2.3, Kv2.1), were expressed in Xenopus oocytes and loaded with Br ions by microinjection. Oocytes were then exposed to extracellular thallium. Under conditions favoring influx of Tl+ ions (negative membrane potential under voltage clamp, or high concentration of extracellular Tl+), crystals of TlBr, visible under low-power microscopy, formed under the membrane in places of high density of K+ channels. Crystals were not formed in uninjected oocytes, but were formed in oocytes expressing as little as 5 microS K+ conductance. The number of observed crystals was much lower than the estimated number of functional channels. Based on the pattern of crystal formation, K+ channels appear to be expressed mostly around the point of cRNA injection when injected either into the animal or vegetal hemisphere. In addition to this pseudopolarized distribution of K+ channels due to localized microinjection of cRNA, a naturally polarized (animal/vegetal side) distribution of K+ channels was also frequently observed when K+ channel cRNA was injected at the equator. A second novel "agarose-hemiclamp" technique was developed to permit direct measurements of K+ currents from different hemispheres of oocytes under two-microelectrode voltage clamp. This technique, together with direct patch-clamping of patches of membrane in regions of high crystal density, confirmed that the localization of TlBr crystals corresponded to the localization of functional K+ channels and suggested a clustered organization of functional channels. With appropriate permeant ion/counterion pairs, this approach may be applicable to the visualization of the membrane distribution of any functional ion channel.

Injection of Super-Critical CO2 in Brine Saturated Sandstone:

NASA Astrophysics Data System (ADS)

Ott, Holger; de Kloe, Kees; Taberner, Conxita; Marcelis, Fons; Makurat, Axel

2010-05-01

Presently, large-scale geological sequestration of CO2, originating from sources like fossil-fueled power plants and contaminated gas production, is seen as an option to reduce anthropogenic emission of greenhouse gases to the atmosphere. Deep saline aquifers and depleted oil and gas fields are potential subsurface deposits for CO2. Injected CO2, however, interacts physically and chemically with the formation leading to uncertainties for CCS projects. One of these uncertainties is related to a dry-out zone that is likely to form around the well bore owing to the injection of dry CO2. Precipitation of salt (mainly halite) that is associated with that drying out of a saline formation has the potential to impair injectivity, and could even lead to the loss of a well. If dry (or under-saturated), super-critical (SC) CO2 is injected into water-bearing geological formations like saline aquifers, water is removed by either advection of the aqueous phase or by evaporation of water and subsequent advection in the injected CO2-rich phase. Both mechanisms act in parallel, however while advection of the aqueous phase decreases with increasing CO2 saturation (diminished mobility), evaporation becomes increasingly important as the aqueous phase becomes immobile. Below residual water saturation, only evaporation takes place and the formation dries out if no additional source of water is available. If water evaporates, the salts originally present in the water are left behind. In case of highly saline formations, the amount of salt that potentially precipitates per unit volume can be quite substantial. It depends on salinity, the solubility limit of water in the CO2 rich phase, and on the ratio of advection and evaporation rates. Since saturations and flow rates cover a large range as functions of space and time close to the well bore, there is no easy answer to the questions whether, where and how salt precipitation impacts injectivity. The present paper presents results of core-flood experiments that were performed to investigate the spatial and temporal precipitation of salt due to the injection of dry CO2 and to understand the underlying mechanisms; super-critical CO2 was injected into brine-saturated sandstone (Berea) samples under realistic pressure and temperature conditions and at high injection rate. To match flow rates that are realistic for the near well-bore area, the experiments were performed on small-scale samples with a cross section of less than 1 cm2. Density profiles were measured by mCT (micro computer tomography) scanning during injection. Reference scans and brine doping with a contrast agent allow the distinction between the CO2-rich phase, the aqueous phase and precipitated solid salt even on pore scale. By means of mCT scanning, spatial and time evolution of halite precipitation in rock samples have been observed under sequestration conditions. Pattern formation of solid salt along the main flow direction as well as a cross-sectional pattern formation has been found. However, while there are areas of high local solid salt accumulation, permeability remained unaffected, which might be a result of the precipitation pattern. The results were complemented by (ex-situ) eSEM/EDAX measurements to study where and how salt precipitates on the microscopic scale. The SEM results cannot be directly translated to in-situ conditions, as salt migrates post-experiment at ambient conditions, but give valuable insight into microscopic processes controlling deposition. Numerical simulations have been performed for a qualitative understanding of principle mechanisms and show a dependency of the observed profile on injection rate and capillary pressure.

Unconventional Hydrocarbon Development Hazards Within the Central United States. Report 1: Overview and Potential Risk to Infrastructure

DTIC Science & Technology

2015-08-01

of the injection purpose, i.e., secondary oil and gas recovery, disposal of waste fluids, geothermal energy, and/or UHP hydraulic fracturing...activities such as reservoir impoundment, mining, wastewater injection, geothermal systems and CO2 capture have been linked directly to induced...activities, e.g., deep fluid injection, geothermal injection, and/or UHP wells, that critically affect deep lithologies and alter the existing mechanical

Shielding synchrotron light sources: Advantages of circular shield walls tunnels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kramer, S. L.; Ghosh, V. J.; Breitfeller, M.

Third generation high brightness light sources are designed to have low emittance and high current beams, which contribute to higher beam loss rates that will be compensated by Top-Off injection. Shielding for these higher loss rates will be critical to protect the projected higher occupancy factors for the users. Top-Off injection requires a full energy injector, which will demand greater consideration of the potential abnormal beam miss-steering and localized losses that could occur. The high energy electron injection beam produce significantly higher neutron component dose to the experimental floor than lower energy injection and ramped operations. High energy neutrons producedmore » in the forward direction from thin target beam losses are a major component of the dose rate outside the shield walls of the tunnel. The convention has been to provide thicker 90° ratchet walls to reduce this dose to the beam line users. We present an alternate circular shield wall design, which naturally and cost effectively increases the path length for this forward radiation in the shield wall and thereby substantially decreasing the dose rate for these beam losses. Here, this shield wall design will greatly reduce the dose rate to the users working near the front end optical components but will challenge the beam line designers to effectively utilize the longer length of beam line penetration in the shield wall. Additional advantages of the circular shield wall tunnel are that it's simpler to construct, allows greater access to the insertion devices and the upstream in tunnel beam line components, as well as reducing the volume of concrete and therefore the cost of the shield wall.« less

Shielding synchrotron light sources: Advantages of circular shield walls tunnels

DOE PAGES

Kramer, S. L.; Ghosh, V. J.; Breitfeller, M.

2016-04-26

Third generation high brightness light sources are designed to have low emittance and high current beams, which contribute to higher beam loss rates that will be compensated by Top-Off injection. Shielding for these higher loss rates will be critical to protect the projected higher occupancy factors for the users. Top-Off injection requires a full energy injector, which will demand greater consideration of the potential abnormal beam miss-steering and localized losses that could occur. The high energy electron injection beam produce significantly higher neutron component dose to the experimental floor than lower energy injection and ramped operations. High energy neutrons producedmore » in the forward direction from thin target beam losses are a major component of the dose rate outside the shield walls of the tunnel. The convention has been to provide thicker 90° ratchet walls to reduce this dose to the beam line users. We present an alternate circular shield wall design, which naturally and cost effectively increases the path length for this forward radiation in the shield wall and thereby substantially decreasing the dose rate for these beam losses. Here, this shield wall design will greatly reduce the dose rate to the users working near the front end optical components but will challenge the beam line designers to effectively utilize the longer length of beam line penetration in the shield wall. Additional advantages of the circular shield wall tunnel are that it's simpler to construct, allows greater access to the insertion devices and the upstream in tunnel beam line components, as well as reducing the volume of concrete and therefore the cost of the shield wall.« less

Inherently aligned microfluidic electrodes composed of liquid metal.

PubMed

So, Ju-Hee; Dickey, Michael D

2011-03-07

This paper describes the fabrication and characterization of microelectrodes that are inherently aligned with microfluidic channels and in direct contact with the fluid in the channels. Injecting low melting point alloys, such as eutectic gallium indium (EGaIn), into microchannels at room temperature (or just above room temperature) offers a simple way to fabricate microelectrodes. The channels that define the shape and position of the microelectrodes are fabricated simultaneously with other microfluidic channels (i.e., those used to manipulate fluids) in a single step; consequently, all of the components are inherently aligned. In contrast, conventional techniques require multiple fabrication steps and registration (i.e., alignment of the electrodes with the microfluidic channels), which are technically challenging. The distinguishing characteristic of this work is that the electrodes are in direct contact with the fluid in the microfluidic channel, which is useful for a number of applications such as electrophoresis. Periodic posts between the microelectrodes and the microfluidic channel prevent the liquid metal from entering the microfluidic channel during injection. A thin oxide skin that forms rapidly and spontaneously on the surface of the metal stabilizes mechanically the otherwise low viscosity, high surface tension fluid within the channel. Moreover, the injected electrodes vertically span the sidewalls of the channel, which allows for the application of uniform electric field lines throughout the height of the channel and perpendicular to the direction of flow. The electrodes are mechanically stable over operating conditions commonly used in microfluidic applications; the mechanical stability depends on the magnitude of the applied bias, the nature of the bias (DC vs. AC), and the conductivity of the solutions in the microfluidic channel. Electrodes formed using alloys with melting points above room temperature ensure mechanical stability over all of the conditions explored. As a demonstration of their utility, the fluidic electrodes are used for electrohydrodynamic mixing, which requires extremely high electric fields (~10(5) V m(-1)).

Sensation of smell and taste during intravenous injection of iodinated contrast media in CT examinations.

PubMed

Yamaguchi, Naoto; Fukushima, Yasuhiro; Yamaguchi, Aiko; Nagasawa, Naoki; Taketomi-Takahashi, Ayako; Suto, Takayuki; Tsushima, Yoshito

2017-01-01

To assess the incidence and types of sensation of smell and taste during i.v. injection of five kinds of contrast media (CM) in CT examinations. 735 patients who underwent contrast-enhanced CT (CE-CT) between 14 March 2016 and 5 April 2016 were enrolled. Medical staff asked patients whether they felt heat sensation and sensation of smell and taste during i.v. injection of CM (one of the following: iopromide, iomeprol, iopamidol, iohexol and ioversol) after their CE-CT. If the patients stated having felt the sensation of smell or taste, they were also asked what kind of smell or taste they sensed. Next, 30 ml of each CM was poured into high-purity pet cups for radiological technologists to smell directly. Radiological technologists were asked whether or not each CM had any smell. The sensations of smell and taste incidence for iopromide were 24.3% and 18.9%, respectively, which were significantly higher than those for other CM (p < 0.05). The highest incidence of the sensation of smell was medicine-ish, and the most frequently noted taste was bitterness. All radiological technologists could directly smell only iopromide, which has an ether group on a side chain and fewer hydroxyl groups. Iopromide showed a higher incidence of sensation of smell and taste than other CM. Advances in knowledge: This was the first investigation of sensation of smell and taste during i.v. injection of CM, and a specific CM showed a higher incidence, which is suspected to be due to its chemical structure.

Sensation of smell and taste during intravenous injection of iodinated contrast media in CT examinations

PubMed Central

Yamaguchi, Naoto; Yamaguchi, Aiko; Nagasawa, Naoki; Taketomi-Takahashi, Ayako; Suto, Takayuki; Tsushima, Yoshito

2017-01-01

Objective: To assess the incidence and types of sensation of smell and taste during i.v. injection of five kinds of contrast media (CM) in CT examinations. Methods: 735 patients who underwent contrast-enhanced CT (CE-CT) between 14 March 2016 and 5 April 2016 were enrolled. Medical staff asked patients whether they felt heat sensation and sensation of smell and taste during i.v. injection of CM (one of the following: iopromide, iomeprol, iopamidol, iohexol and ioversol) after their CE-CT. If the patients stated having felt the sensation of smell or taste, they were also asked what kind of smell or taste they sensed. Next, 30 ml of each CM was poured into high-purity pet cups for radiological technologists to smell directly. Radiological technologists were asked whether or not each CM had any smell. Results: The sensations of smell and taste incidence for iopromide were 24.3% and 18.9%, respectively, which were significantly higher than those for other CM (p < 0.05). The highest incidence of the sensation of smell was medicine-ish, and the most frequently noted taste was bitterness. All radiological technologists could directly smell only iopromide, which has an ether group on a side chain and fewer hydroxyl groups. Conclusion: Iopromide showed a higher incidence of sensation of smell and taste than other CM. Advances in knowledge: This was the first investigation of sensation of smell and taste during i.v. injection of CM, and a specific CM showed a higher incidence, which is suspected to be due to its chemical structure. PMID:27805431

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

PubMed Central

Kass-Eisler, A; Falck-Pedersen, E; Alvira, M; Rivera, J; Buttrick, P M; Wittenberg, B A; Cipriani, L; Leinwand, L A

1993-01-01

To optimize the use of modified adenoviruses as vectors for gene delivery to the myocardium, we have characterized infection of cultured fetal and adult rat cardiac myocytes in vitro and of adult cardiac myocytes in vivo by using a replication-defective adenovirus carrying the chloramphenicol acetyltransferase (CAT) reporter gene driven by the cytomegalovirus promoter (AdCMVCATgD). In vitro, virtually all fetal or adult cardiocytes express the CAT gene when infected with 1 plaque-forming unit of virus per cell. CAT enzymatic activity can be detected in these cells as early as 4 hr after infection, reaching near-maximal levels at 48 hr. In fetal cells, CAT expression was maintained without a loss in activity for at least 1 week. Using in vitro studies as a guide, we introduced the AdCMVCATgD virus directly into adult rat myocardium and compared the expression results obtained from virus injection with those obtained by direct injection of pAdCMVCATgD plasmid DNA. The amount of CAT activity resulting from adenovirus infection of the myocardium was orders of magnitude higher than that seen from DNA injection and was proportional to the amount of input virus. Immunostaining for CAT protein in cardiac tissue sections following adenovirus injection demonstrated large numbers of positive cells, reaching nearly 100% of the myocytes in many regions of the heart. Expression of genes introduced by adenovirus peaked at 5 days but was still detectable 55 days following infection. Adenoviruses are therefore a very useful tool for high-efficiency gene transfer into the cardiovascular system. Images Fig. 1 Fig. 5 PMID:8265580

Reservoir fluid and gas chemistry during CO2 injection at the Cranfield field, Mississippi, USA

NASA Astrophysics Data System (ADS)

Lu, J.; Kharaka, Y. K.; Cole, D. R.; Horita, J.; Hovorka, S.

2009-12-01

At Cranfield field, Mississippi, USA, a monitored CO2-EOR project provides a unique opportunity to understand geochemical interactions of injected CO2 within the reservoir. Cranfield field, discovered in 1943, is a simple anticlinal four-way closure and had a large gas cap surrounded by an oil ring (Mississippi Oil and Gas Board, 1966). The field was abandoned in 1966. The reservoir returned to original reservoir pressure (hydrostatic pressure) by a strong aquifer drive by 2008. The reservoir is in the lower Tuscaloosa Formation at depths of more than 3000 m. It is composed of stacked and incised channel fills and is highly heterogeneous vertically and horizontally. A variable thickness (5 to 15 m) of terrestrial mudstone directly overlies the basal sandstone providing the primary seal, isolating the injection interval from a series of fluvial sand bodies occurring in the overlying 30 m of section. Above these fluvial channels, the marine mudstone of the Middle Tuscaloosa forms a continuous secondary confining system of approximately 75 m. The sandstones of the injection interval are rich in iron, containing abundant diagenetic chamosite (ferroan chlorite), hematite and pyrite. Geochemical modeling suggests that the iron-bearing minerals will be dissolved in the face of high CO2 and provide iron for siderite precipitation. CO2 injection by Denbury Resources Inc. begun in mid-July 2008 on the north side of the field with rates at ~500,000 tones per year. Water and gas samples were taken from seven production wells after eight months of CO2 injection. Gas analyses from three wells show high CO2 concentrations (up to 90 %) and heavy carbon isotopic signatures similar to injected CO2, whereas the other wells show original gas composition and isotope. The mixing ratio between original and injected CO2 is calculated based on its concentration and carbon isotope. However, there is little variation in fluid samples between the wells which have seen various levels of CO2. Comparison between preinjection and postinjection fluid analyses also shows little difference. It suggests that CO2 injection has not induced significant mineral-water reactions to change water chemistry. In October 2009, CO2 will be injected into the down-dip, non-productive Tuscaloosa Formation on the east side of the same field. In-situ fluid and gas samples will be collected using downhole U-tube. Fluid chemistry data through time will reveal mineral reactions during and after injection and confine timescales of the interactions. This project was funded thought the National Energy Technology Laboratory Regional Carbon Sequestration Partnership Program as part of the Southeast Regional Carbon Sequestration Partnership.

Novel Applications of High Speed Optical-Injection Locked Lasers

DTIC Science & Technology

2010-07-31

transimpedance amplifiers (TIAs) and optical hybrids. We have also demonstrated digital communications on a 60 GHz optical subcarrier using directly modulated...of the devices. Also included on the mask are both single ended as well as differential transimpedance amplifiers (TIAs). These circuits have a... transimpedance amplifiers with the photo-transistors as the input stage. Simulations predict a transimpedance bandwidth of 120 GHz for the single

Over compression influence to the performances of the spark ignition engines

NASA Astrophysics Data System (ADS)

Rakosi, E.; Talif, S. G.; Manolache, G.

2016-08-01

This paper presents the theoretical and experimental results of some procedures used in improving the performances of the automobile spark ignition engines. The study uses direct injection and high over-compression applied to a standard engine. To this purpose, the paper contains both the constructive solutions and the results obtained from the test bed concerning the engine power indices, fuel consumption and exhaust emissions.

Nanoparticle Plasma Jet as Fast Probe for Runaway Electrons in Tokamak Disruptions

NASA Astrophysics Data System (ADS)

Bogatu, I. N.; Galkin, S. A.

2017-10-01

Successful probing of runaway electrons (REs) requires fast (1 - 2 ms) high-speed injection of enough mass able to penetrate through tokamak toroidal B-field (2 - 5 T) over 1 - 2 m distance with large assimilation fraction in core plasma. A nanoparticle plasma jet (NPPJ) from a plasma gun is a unique combination of millisecond trigger-to-delivery response and mass-velocity of 100 mg at several km/s for deep direct injection into current channel of rapidly ( 1 ms) cooling post-TQ core plasma. After C60 NPPJ test bed demonstration we started to work on ITER-compatible boron nitride (BN) NPPJ. Once injected into plasma, BN NP undergoes ablative sublimation, thermally decomposes into B and N, and releases abundant B and N high-charge ions along plasma-traversing path and into the core. We present basic characteristics of our BN NPPJ concept and first results from B and N ions on Zeff > 1 effect on REs dynamics by using a self-consistent model for RE current density. Simulation results of BNQ+ NPPJ penetration through tokamak B-field to RE beam location performed with Hybrid Electro-Magnetic code (HEM-2D) are also presented. Work supported by U.S. DOE SBIR Grant.

Application of a novel large-volume injection method using a stomach-shaped inlet liner in capillary gas chromatographic trace analysis of dioxins in human milk and plasma.

PubMed

Saito, Koichi; Ohmura, Atsuko; Takekuma, Mikiko; Sasano, Ryoichi; Matsuki, Yasuhiko; Nakazawa, Hiroyuki

2007-06-01

A newly developed large-volume injection (LVI) technique that employs a unique stomach-shaped inlet liner (SSIL) inside of a programmable temperature vaporizer was used for the determination of trace amounts of dioxins in human milk and plasma. The initial temperature and the initial dwelling time of the inlet and the kind of solvent used were found to be critical in determining the analytical sensitivity of dioxins due to the loss of these relatively volatile compounds during solvent vaporization. Human milk and plasma were purified and fractionated by pre-packed multi-layered silica-gel chromatography and activated carbon silica-gel column chromatography. A 20-microL aliquot of the fraction collected from the chromatography with toluene was directly applied to the LVI system in high-resolution gas chromatography/high-resolution mass spectrometry. Excellent correlation (r > 0.97) between the values obtained by the LVI method using the SSIL device and those by the conventional regular-volume splitless injection method was obtained for PCDDs, PCDFs and non-ortho PCBs in human milk and plasma samples.

Flow injection gas chromatography with sulfur chemiluminescence detection for the analysis of total sulfur in complex hydrocarbon matrixes.

PubMed

Hua, Yujuan; Hawryluk, Myron; Gras, Ronda; Shearer, Randall; Luong, Jim

2018-01-01

A fast and reliable analytical technique for the determination of total sulfur levels in complex hydrocarbon matrices is introduced. The method employed flow injection technique using a gas chromatograph as a sample introduction device and a gas phase dual-plasma sulfur chemiluminescence detector for sulfur quantification. Using the technique described, total sulfur measurement in challenging hydrocarbon matrices can be achieved in less than 10 s with sample-to-sample time <2 min. The high degree of selectivity and sensitivity toward sulfur compounds of the detector offers the ability to measure low sulfur levels with a detection limit in the range of 20 ppb w/w S. The equimolar response characteristic of the detector allows the quantitation of unknown sulfur compounds and simplifies the calibration process. Response is linear over a concentration range of five orders of magnitude, with a high degree of repeatability. The detector's lack of response to hydrocarbons enables direct analysis without the need for time-consuming sample preparation and chromatographic separation processes. This flow injection-based sulfur chemiluminescence detection technique is ideal for fast analysis or trace sulfur analysis. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Basic Behavior of CNG DI Combustion in a Spark-Ignited Rapid Compression Machine

NASA Astrophysics Data System (ADS)

Huang, Zuohua; Shiga, Seiichi; Ueda, Takamasa; Jingu, Nobuhisa; Nakamura, Hisao; Ishima, Tsuneaki; Obokata, Tomio; Tsue, Mitsuhiro; Kono, Michikata

A basic characteristics of compressed natural gas direct-injection (CNG DI) combustion was studied by using a rapid compression machine. Results show that comparing with homogeneous mixture, CNG DI has short combustion duration, high pressure rise due to combustion, and high rate of heat release, which are considered to come from the charge stratification and the gas flow generated by the fuel injection. CNG DI can realize extremely lean combustion which reaches 0.03 equivalence ratio, φ. Combustion duration, maximum pressure rise due to combustion and combustion efficiency are found to be insensitive to the injection modes. Unburned methane showed almost the same level as that of homogeneous mixture combustion. CO increased steeply with the increase in φ when φ was greater than 0.8 due to the excessive stratification, and NOx peak value shifted to the region of lower φ. Combustion inefficiency maintains less than 0.08 in the range of φ from 0.1 to 0.9 and increases at very low φ due to bulk quenching and at higher φ due to excessive stratification. The combustion efficiency estimated from combustion products shows good agreement with that of heat release analysis.

CCS Site Optimization by Applying a Multi-objective Evolutionary Algorithm to Semi-Analytical Leakage Models

NASA Astrophysics Data System (ADS)

Cody, B. M.; Gonzalez-Nicolas, A.; Bau, D. A.

2011-12-01

Carbon capture and storage (CCS) has been proposed as a method of reducing global carbon dioxide (CO2) emissions. Although CCS has the potential to greatly retard greenhouse gas loading to the atmosphere while cleaner, more sustainable energy solutions are developed, there is a possibility that sequestered CO2 may leak and intrude into and adversely affect groundwater resources. It has been reported [1] that, while CO2 intrusion typically does not directly threaten underground drinking water resources, it may cause secondary effects, such as the mobilization of hazardous inorganic constituents present in aquifer minerals and changes in pH values. These risks must be fully understood and minimized before CCS project implementation. Combined management of project resources and leakage risk is crucial for the implementation of CCS. In this work, we present a method of: (a) minimizing the total CCS cost, the summation of major project costs with the cost associated with CO2 leakage; and (b) maximizing the mass of injected CO2, for a given proposed sequestration site. Optimization decision variables include the number of CO2 injection wells, injection rates, and injection well locations. The capital and operational costs of injection wells are directly related to injection well depth, location, injection flow rate, and injection duration. The cost of leakage is directly related to the mass of CO2 leaked through weak areas, such as abandoned oil wells, in the cap rock layers overlying the injected formation. Additional constraints on fluid overpressure caused by CO2 injection are imposed to maintain predefined effective stress levels that prevent cap rock fracturing. Here, both mass leakage and fluid overpressure are estimated using two semi-analytical models based upon work by [2,3]. A multi-objective evolutionary algorithm coupled with these semi-analytical leakage flow models is used to determine Pareto-optimal trade-off sets giving minimum total cost vs. maximum mass of CO2 sequestered. This heuristic optimization method is chosen because of its robustness in optimizing large-scale, highly non-linear problems. Trade-off curves are developed for multiple fictional sites with the intent of clarifying how variations in domain characteristics (aquifer thickness, aquifer and weak cap rock permeability, the number of weak cap rock areas, and the number of aquifer-cap rock layers) affect Pareto-optimal fronts. Computational benefits of using semi-analytical leakage models are explored and discussed. [1] Birkholzer, J. (2008) "Research Project on CO2 Geological Storage and Groundwater Resources: Water Quality Effects Caused by CO2 Intrusion into Shallow Groundwater" Berkeley (CA): Lawrence Berkeley National Laboratory (US); 2008 Oct. 473 p. Report No.: 510-486-7134. [2] Celia, M.A. and Nordbotten, J.M. (2011) "Field-scale application of a semi-analytical model for estimation of CO2 and brine leakage along old wells" International Journal of Greenhouse Gas Control, 5 (2011), 257-269. [3] Nordbotten, J.M. and Celia, M.A. (2009) "Model for CO2 leakage including multiple geological layers and multiple leaky wells" Environ. Sci. Technol., 43, 743-749.

Intra-lymph node injection of biodegradable polymer particles.

PubMed

Andorko, James I; Tostanoski, Lisa H; Solano, Eduardo; Mukhamedova, Maryam; Jewell, Christopher M

2014-01-02

Generation of adaptive immune response relies on efficient drainage or trafficking of antigen to lymph nodes for processing and presentation of these foreign molecules to T and B lymphocytes. Lymph nodes have thus become critical targets for new vaccines and immunotherapies. A recent strategy for targeting these tissues is direct lymph node injection of soluble vaccine components, and clinical trials involving this technique have been promising. Several biomaterial strategies have also been investigated to improve lymph node targeting, for example, tuning particle size for optimal drainage of biomaterial vaccine particles. In this paper we present a new method that combines direct lymph node injection with biodegradable polymer particles that can be laden with antigen, adjuvant, or other vaccine components. In this method polymeric microparticles or nanoparticles are synthesized by a modified double emulsion protocol incorporating lipid stabilizers. Particle properties (e.g. size, cargo loading) are confirmed by laser diffraction and fluorescent microscopy, respectively. Mouse lymph nodes are then identified by peripheral injection of a nontoxic tracer dye that allows visualization of the target injection site and subsequent deposition of polymer particles in lymph nodes. This technique allows direct control over the doses and combinations of biomaterials and vaccine components delivered to lymph nodes and could be harnessed in the development of new biomaterial-based vaccines.

Memory modulation across neural systems: intra-amygdala glucose reverses deficits caused by intraseptal morphine on a spatial task but not on an aversive task.

PubMed

McNay, E C; Gold, P E

1998-05-15

Based largely on dissociations of the effects of different lesions on learning and memory, memories for different attributes appear to be organized in independent neural systems. Results obtained with direct injections of drugs into one brain region at a time support a similar conclusion. The present experiments investigated the effects of simultaneous pharmacological manipulation of two neural systems, the amygdala and the septohippocampal system, to examine possible interactions of memory modulation across systems. Morphine injected into the medial septum impaired memory both for avoidance training and during spontaneous alternation. When glucose was concomitantly administered to the amygdala, glucose reversed the morphine-induced deficits in memory during alternation but not for avoidance training. These results suggest that the amygdala is involved in modulation of spatial memory processes and that direct injections of memory-modulating drugs into the amygdala do not always modulate memory for aversive events. These findings are contrary to predictions from the findings of lesion studies and of studies using direct injections of drugs into single brain areas. Thus, the independence of neural systems responsible for processing different classes of memory is less clear than implied by studies using lesions or injections of drugs into single brain areas.

Gas-Enhanced Ultra-High Shear Mixing: A Concept and Applications

NASA Astrophysics Data System (ADS)

Czerwinski, Frank; Birsan, Gabriel

2017-04-01

The processes of mixing, homogenizing, and deagglomeration are of paramount importance in many industries for modifying properties of liquids or liquid-based dispersions at room temperature and treatment of molten or semi-molten alloys at high temperatures, prior to their solidification. To implement treatments, a variety of technologies based on mechanical, electromagnetic, and ultrasonic principles are used commercially or tested at the laboratory scale. In a large number of techniques, especially those tailored toward metallurgical applications, the vital role is played by cavitation, generation of gas bubbles, and their interaction with the melt. This paper describes a novel concept exploring an integration of gas injection into the shear zone with ultra-high shear mixing. As revealed via experiments with a prototype of the cylindrical rotor-stator apparatus and transparent media, gases injected radially through the high-speed rotor generate highly refined bubbles of high concentration directly in the shear zone of the mixer. It is believed that an interaction of large volume of fine gas bubbles with the liquid, superimposed on ultra-high shear, will enhance mixing capabilities and cause superior refining and homogenizing of the liquids or solid-liquid slurries, thus allowing their effective property modification.

STUDIES ON THE PATHOGENESIS OF FEVER

PubMed Central

King, M. Kenton; Wood, W. Barry

1958-01-01

By means of a method designed to compare the febrile responses produced by intracarotid and intravenous injections, the endogenous pyrogen, which is contained in leucocytic exudates and is present in the serum of rabbits 2 hours after intravenous injections of typhoid vaccine, has been shown to act directly upon the thermoregulatory centers of the brain. In contrast, the exogenous bacterial pyrogen present in serum obtained 5 minutes after vaccine injections was found to act by a different and less direct mechanism. These observations add strong support to the original hypothesis that endogenous pyrogen, presumably derived from polymorphonuclear leucocytes, is an essential factor in the pathogenesis of endotoxin fever. PMID:13491763

Direct link of a mid-infrared QCL to a frequency comb by optical injection.

PubMed

Borri, S; Galli, I; Cappelli, F; Bismuto, A; Bartalini, S; Cancio, P; Giusfredi, G; Mazzotti, D; Faist, J; De Natale, P

2012-03-15

A narrow-linewidth comb-linked nonlinear source is used as master radiation to injection lock a room-temperature mid-infrared quantum cascade laser (QCL). This process leads to a direct lock of the QCL to the optical frequency comb, providing the unique features of narrow linewidth, absolute frequency, higher output power, and wide mode-hop-free tunability. The QCL reproduces the injected radiation within more than 94%, with a reduction of the frequency-noise spectral density by 3 to 4 orders of magnitude up to about 100 kHz, and a linewidth narrowing from a few MHz to 20 kHz.

Characterization of Swirl-Venturi Lean Direct Injection Designs for Aviation Gas-Turbine Combustion

NASA Technical Reports Server (NTRS)

Heath, Christopher M.

2013-01-01

Injector geometry, physical mixing, chemical processes, and engine cycle conditions together govern performance, operability and emission characteristics of aviation gas-turbine combustion systems. The present investigation explores swirl-venturi lean direct injection combustor fundamentals, characterizing the influence of key geometric injector parameters on reacting flow physics and emission production trends. In this computational study, a design space exploration was performed using a parameterized swirl-venturi lean direct injector model. From the parametric geometry, 20 three-element lean direct injection combustor sectors were produced and simulated using steady-state, Reynolds-averaged Navier-Stokes reacting computations. Species concentrations were solved directly using a reduced 18-step reaction mechanism for Jet-A. Turbulence closure was obtained using a nonlinear ?-e model. Results demonstrate sensitivities of the geometric perturbations on axially averaged flow field responses. Output variables include axial velocity, turbulent kinetic energy, static temperature, fuel patternation and minor species mass fractions. Significant trends have been reduced to surrogate model approximations, intended to guide future injector design trade studies and advance aviation gas-turbine combustion research.

Arterial and venous embolization: Declotting of dialysis shunts by direct injection of streptokinase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeit, R.M.

1986-06-01

During the past 33 months, thrombolysis of 79 clotted hemodialysis shunts was attempted by injecting small quantities of dilute streptokinase solution directly into the clotted shunt, followed by massage of the clot. Embolization of clot fragments in six of 79 cases (7.6%) was demonstrated angiographically. In four of the six cases embolization involved the brachial artery or its branches. In one case embolization involved an arm vein, and in one case embolization involved both the bracial artery and axillary vein. All patients remained asymptomatic, and repeat angiographic study, usually performed the following day, showed resolution of the emboli in fourmore » of five cases. The incidence of embolization in direct-injection thrombolysis reported in this study appears to be comparable to that reported in studies using the streptokinase infusion technique.« less

Effect of Fuel Properties on Injection Characteristics of Four Different Diesel Injection Systems.

DTIC Science & Technology

1985-12-01

Effects on Combustion in Direct Injection Diesel Engines," SAE Technical Paper Series, No. 850108, International Congress and Exposi - tion, Detroit, MI...NIEMEYER) I AMXSY-CR 1 DEFENSE STANDARDIZATION OFFICE ABE SYNR R ATTN DR MILER 1 ABERDEEN PROVING GROUND MDATTN: DR S ILLE I 10-06 . 2 1005-5006 5203

An experimental study of flame stability in a directly-fueled wall cavity with a supersonic free stream

NASA Astrophysics Data System (ADS)

Rasmussen, Chadwick Clifford

An extensive study of flame stability in a cavity-based fuel injector/flameholder has been performed. Flames were stabilized in cavities with two different aft wall configurations and length to depth ratios of 3 and 4. Fuel was injected directly into the cavity using two injector configurations. Fuel injected from the aft wall of the cavity entered directly into the recirculation zone and provided desirable performance near the lean blowout limit. At high fuel flowrates, the cavity became flooded with fuel and rich blowout occurred. When fuel was injected from the floor of the cavity, excess fuel was directed out of the cavity which allowed for flame stabilization at extremely high fuel flowrates; however, this phenomenon also resulted in suboptimal performance near the lean limit where the blowout point was less predictable. Images of planar laser-induced fluorescence (PLIF) of CH, OH, and formaldehyde give insight into the flameholding mechanisms. CH layers in the cavity are thin and continuous and show structure that is comparable to lifted jet flames, while broad CH zones are sometimes observed in the shear layer. OH PLIF images show that hot recirculated products are always present at the location of flame stabilization, whereas images of formaldehyde indicate that partial premixing takes place in the shear layer portion of the flame. Nonreacting measurements of the boundary layer and the free stream velocity profiles were obtained to provide necessary boundary conditions for computational modeling. Mean and instantaneous velocity profiles were determined for the nonreacting flow using particle image velocimetry (PIV). A correlation of the blowout points for a directly-fueled cavity in a supersonic flow was accomplished using a Damkohler number and an equivalence ratio based upon an effective air mass flowrate. The chemical time was formulated using a generic measure of the reaction rate, tauc ˜ alpha/ S2L , which was found to be adequate for correlating lean blowout data from methane, ethylene, acetylene, and hydrogen flames. Blowout data was collected at a number of conditions with varied pressure and temperature and Mach numbers of 2, 2.4, and 3. The effective air mass flowrate was determined using scaling laws for compressible mixing layers, which correctly incorporated the impact of compressibility on air entrainment.

Inter-plume aerodynamics for gasoline spray collapse

DOE PAGES

Sphicas, Panos; Pickett, Lyle M.; Skeen, Scott A.; ...

2017-11-10

The collapse or merging of individual plumes of direct-injection gasoline injectors is of fundamental importance to engine performance because of its impact on fuel–air mixing. But, the mechanisms of spray collapse are not fully understood and are difficult to predict. The purpose of this work is to study the aerodynamics in the inter-spray region, which can potentially lead to plume collapse. High-speed (100 kHz) particle image velocimetry is applied along a plane between plumes to observe the full temporal evolution of plume interaction and potential collapse, resolved for individual injection events. Supporting information along a line of sight is obtainedmore » using simultaneous diffused back illumination and Mie-scatter techniques. Experiments are performed under simulated engine conditions using a symmetric eight-hole injector in a high-temperature, high-pressure vessel at the “Spray G” operating conditions of the engine combustion network. Indicators of plume interaction and collapse include changes in counter-flow recirculation of ambient gas toward the injector along the axis of the injector or in the inter-plume region between plumes. Furthermore, the effect of ambient temperature and gas density on the inter-plume aerodynamics and the subsequent plume collapse are assessed. Increasing ambient temperature or density, with enhanced vaporization and momentum exchange, accelerates the plume interaction. Plume direction progressively shifts toward the injector axis with time, demonstrating that the plume interaction and collapse are inherently transient.« less

Inter-plume aerodynamics for gasoline spray collapse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sphicas, Panos; Pickett, Lyle M.; Skeen, Scott A.

The collapse or merging of individual plumes of direct-injection gasoline injectors is of fundamental importance to engine performance because of its impact on fuel–air mixing. But, the mechanisms of spray collapse are not fully understood and are difficult to predict. The purpose of this work is to study the aerodynamics in the inter-spray region, which can potentially lead to plume collapse. High-speed (100 kHz) particle image velocimetry is applied along a plane between plumes to observe the full temporal evolution of plume interaction and potential collapse, resolved for individual injection events. Supporting information along a line of sight is obtainedmore » using simultaneous diffused back illumination and Mie-scatter techniques. Experiments are performed under simulated engine conditions using a symmetric eight-hole injector in a high-temperature, high-pressure vessel at the “Spray G” operating conditions of the engine combustion network. Indicators of plume interaction and collapse include changes in counter-flow recirculation of ambient gas toward the injector along the axis of the injector or in the inter-plume region between plumes. Furthermore, the effect of ambient temperature and gas density on the inter-plume aerodynamics and the subsequent plume collapse are assessed. Increasing ambient temperature or density, with enhanced vaporization and momentum exchange, accelerates the plume interaction. Plume direction progressively shifts toward the injector axis with time, demonstrating that the plume interaction and collapse are inherently transient.« less

Rotary engine developments at Curtiss-Wright over the past 20 years and review of general aviation engine potential. [with direct chamber injection

NASA Technical Reports Server (NTRS)

Jones, C.

1978-01-01

The development of the rotary engine as a viable power plant capable of wide application is reviewed. Research results on the stratified charge engine with direct chamber injection are included. Emission control, reduced fuel consumption, and low noise level are among the factors discussed in terms of using the rotary engine in general aviation aircraft.

Study of Direct RF Injection on Microcontroller

DTIC Science & Technology

2013-06-06

TASK NUMBER PPM00010812 5f. WORK UNIT NUMBER EF002775 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) The University of Texas at Dallas Dept. of...Electrical Engineering Richardson, TX 75080 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS...test board and micro-instruction. 2.3 Organization of Report Section 3.0 describes the experiment procedure for direct RF injection. Section 4.0

Fabrication and characterization of a germanium nanowire light emitting diode

NASA Astrophysics Data System (ADS)

Greil, Johannes; Bertagnolli, Emmerich; Salem, Bassem; Baron, Thierry; Gentile, Pascal; Lugstein, Alois

2017-12-01

In this letter, we demonstrate the feasibility of a germanium nanowire light emitting diode as a reasonable approach for downscaling of CMOS compatible light sources. We show room-temperature direct bandgap electroluminescence from axial p-n junction nanowire devices. The electron population in the Γ valley, necessary for direct bandgap emission, is achieved by high injection current densities. Carrier temperature is consistently found to be higher than the lattice temperature, indicating inhibited carrier cooling in small diameter wires. Strong polarization of the emission parallel to the nanowire axis is observed and attributed to dielectric contrast phenomena.

Tandem betatron

DOEpatents

Keinigs, Rhonald K.

1992-01-01

Two betatrons are provided in tandem for alternately accelerating an electron beam to avoid the single flux swing limitation of conventional betatrons and to accelerate the electron beam to high energies. The electron beam is accelerated in a first betatron during a period of increasing magnetic flux. The eletron beam is extracted from the first betatron as a peak magnetic flux is reached and then injected into a second betatron at a time of minimum magnetic flux in the second betatron. The cycle may be repeated until the desired electron beam energy is obtained. In one embodiment, the second betatron is axially offset from the first betatron to provide for electron beam injection directly at the axial location of the beam orbit in the second betatron.

Experimental Results from a Flat Plate, Turbulent Boundary Layer Modified for the Purpose of Drag Reduction

NASA Astrophysics Data System (ADS)

Elbing, Brian R.

2006-11-01

Recent experiments on a flat plate, turbulent boundary layer at high Reynolds numbers (>10^7) were performed to investigate various methods of reducing skin friction drag. The methods used involved injecting either air or a polymer solution into the boundary layer through a slot injector. Two slot injectors were mounted on the model with one located 1.4 meters downstream of the nose and the second located 3.75 meters downstream. This allowed for some synergetic experiments to be performed by varying the injections from each slot and comparing the skin friction along the plate. Skin friction measurements were made with 6 shear stress sensors flush mounted along the stream-wise direction of the model.

Fuel processor for fuel cell power system

DOEpatents

Vanderborgh, Nicholas E.; Springer, Thomas E.; Huff, James R.

1987-01-01

A catalytic organic fuel processing apparatus, which can be used in a fuel cell power system, contains within a housing a catalyst chamber, a variable speed fan, and a combustion chamber. Vaporized organic fuel is circulated by the fan past the combustion chamber with which it is in indirect heat exchange relationship. The heated vaporized organic fuel enters a catalyst bed where it is converted into a desired product such as hydrogen needed to power the fuel cell. During periods of high demand, air is injected upstream of the combustion chamber and organic fuel injection means to burn with some of the organic fuel on the outside of the combustion chamber, and thus be in direct heat exchange relation with the organic fuel going into the catalyst bed.

System and method for generating current by selective electron heating

DOEpatents

Fisch, Nathaniel J.; Boozer, Allen H.

1984-01-01

A system for the generation of toroidal current in a plasma which is prepared in a toroidal magnetic field. The system utilizes the injection of high-frequency waves into the plasma by means of waveguides. The wave frequency and polarization are chosen such that when the waveguides are tilted in a predetermined fashion, the wave energy is absorbed preferentially by electrons traveling in one toroidal direction. The absorption of energy in this manner produces a toroidal electric current even when the injected waves themselves do not have substantial toroidal momentum. This current can be continuously maintained at modest cost in power and may be used to confine the plasma. The system can operate efficiently on fusion grade tokamak plasmas.

Physicochemical characterization of particulate emissions from a compression ignition engine employing two injection technologies and three fuels.

PubMed

Surawski, N C; Miljevic, B; Ayoko, G A; Roberts, B A; Elbagir, S; Fairfull-Smith, K E; Bottle, S E; Ristovski, Z D

2011-07-01

Alternative fuels and injection technologies are a necessary component of particulate emission reduction strategies for compression ignition engines. Consequently, this study undertakes a physicochemical characterization of diesel particulate matter (DPM) for engines equipped with alternative injection technologies (direct injection and common rail) and alternative fuels (ultra low sulfur diesel, a 20% biodiesel blend, and a synthetic diesel). Particle physical properties were addressed by measuring particle number size distributions, and particle chemical properties were addressed by measuring polycyclic aromatic hydrocarbons (PAHs) and reactive oxygen species (ROS). Particle volatility was determined by passing the polydisperse size distribution through a thermodenuder set to 300 °C. The results from this study, conducted over a four point test cycle, showed that both fuel type and injection technology have an impact on particle emissions, but injection technology was the more important factor. Significant particle number emission (54%-84%) reductions were achieved at half load operation (1% increase-43% decrease at full load) with the common rail injection system; however, the particles had a significantly higher PAH fraction (by a factor of 2 to 4) and ROS concentrations (by a factor of 6 to 16) both expressed on a test-cycle averaged basis. The results of this study have significant implications for the health effects of DPM emissions from both direct injection and common rail engines utilizing various alternative fuels.

Geomechanics of Hydraulic Stimulation in Geothermal Systems: Designing and Implementing a Successful Enhanced Geothermal System at Desert Peak, Nevada

NASA Astrophysics Data System (ADS)

Hickman, S. H.; Davatzes, N. C.; Zemach, E.; Chabora, E.; Lutz, S.; Rose, P.; Majer, E. L.; Robertson-Tait, A.

2013-12-01

Creation of an Enhanced Geothermal System (EGS) in hot but low-permeability rocks involves hydraulic stimulation of fracture permeability to develop a complex heat exchange system with low hydraulic impedance. An integrated study of stress, fractures and rock mechanical properties was conducted to develop the geomechanical framework for a multi-stage EGS stimulation in Desert Peak well 27-15, located at the low-permeability margins of an active geothermal field. The stimulation targeted silicified tuffs and metamorphosed mudstones at depths of 0.9 to 1.8 km and temperatures ~180 to 210° C. Drilling-induced tensile fractures in image logs from well 27-15 show that the least horizontal principal stress (Shmin) is consistent with normal faulting on ESE- and WNW-dipping fractures mapped at the surface and seen in the image logs. A hydraulic fracturing stress measurement indicates that the magnitude of Shmin at ~0.93 km depth is 0.61 of the calculated vertical stress. Coulomb failure calculations using these stresses together with measurements of friction and permeability on core predict that dilatant shear failure should be induced on pre-existing conjugate normal faults once pore pressures are increased ~2.5 MPa or more above ambient values, generating a zone of enhanced permeability elongated in the direction toward active geothermal wells ~0.5 km to the SSW. Hydraulic stimulation of well 27-15 began in September 2010 by injecting water into the open-hole interval between the casing shoe at 0.9 km depth and a temporary cement plug at 1.1 km. Stimulation was monitored by combined surface and down-hole seismic monitoring, inter-well tracer testing and periodic pressure-temperature-flowmeter logging. An initial stage of low-pressure (shear) stimulation was conducted for ~100 days at a series of pressure steps Shmin and injection rates up to 2800 l/min, resulting in an additional 6-fold increase in injectivity. Numerous microearthquakes induced during this high-pressure stage along with tracer testing demonstrated growth of the stimulated volume and establishment of a strong hydrologic connection between well 27-15 and geothermal production wells to the SSW. After drilling out the cement plug and opening up the stimulation zone to the total depth of the well (1.8 km), additional stages of low- and high-pressure stimulation were carried out in early 2013. This full-hole stimulation was characterized by continued growth of the microseismic cloud in the NNE - SSW direction and strong tracer returns to the main geothermal field. A cumulative 175-fold injectivity gain was achieved in well 27-15 over the entire EGS project, which exceeded project goals. The Desert Peak geomechanical model predicted both the approximate initiation criteria and directional characteristics of the injection-induced shear and tensile failure and resulting permeability gains that led to success of this EGS project.

Efficacy and safety of collagenase clostridium histolyticum in the treatment of proximal interphalangeal joints in dupuytren contracture: combined analysis of 4 phase 3 clinical trials.

PubMed

Badalamente, Marie A; Hurst, Lawrence C; Benhaim, Prosper; Cohen, Brian M

2015-05-01

To examine the results of proximal interphalangeal (PIP) joint contractures from 4 phase 3 clinical trials of collagenase clostridium histolyticum (CCH) injection for Dupuytren contracture. Patients enrolled in Collagenase Option for Reduction of Dupuytren I/II and JOINT I/II with one or more PIP joint contractures (20° to 80°) received CCH 0.58 mg/0.20 mL or placebo (Collagenase Option for Reduction of Dupuytren I/II only) injected directly into a palpable cord. The percentage of PIP joints achieving clinical success (0° to 5° of full extension), clinical improvement (50% or more reduction in baseline contracture), and range of motion improvement at 30 days after the first and last CCH injections was assessed. The PIP joint contractures were classified into low (40° or less) and high (more than 40°) baseline severity. Adverse events were recorded. A total of 506 adults (mean age, 63 ± 10 y; 80% male) received 1,165 CCH injections in 644 PIP joint cords (mean, 1.6 injections/cord). Most patients (60%) received 1 injection, with 24%, 16%, and 1% receiving 2, 3, and 4 injections, respectively. Clinical success and clinical improvement occurred in 27% and 49% of PIP joints after one injection and in 34% and 58% after the last injection. Patients with lower baseline severity showed greater improvement and response was comparable between fingers, as were improvements in range of motion. Adverse events occurring in more than 10% of patients were peripheral edema (58%), contusion (38%), injection site hemorrhage (23%), injection site pain (21%), injection site swelling (16%), and tenderness (13%). This incidence was consistent with data reported in phase 3 trials. Two tendon ruptures occurred. No further ruptures occurred after a modified injection technique was adopted. Collagenase clostridium histolyticum was effective and well tolerated in the short term in patients with Dupuytren PIP joint contractures. Therapeutic II. Copyright © 2015 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

High-energy coherent terahertz radiation emitted by wide-angle electron beams from a laser-wakefield accelerator

NASA Astrophysics Data System (ADS)

Yang, Xue; Brunetti, Enrico; Jaroszynski, Dino A.

2018-04-01

High-charge electron beams produced by laser-wakefield accelerators are potentially novel, scalable sources of high-power terahertz radiation suitable for applications requiring high-intensity fields. When an intense laser pulse propagates in underdense plasma, it can generate femtosecond duration, self-injected picocoulomb electron bunches that accelerate on-axis to energies from 10s of MeV to several GeV, depending on laser intensity and plasma density. The process leading to the formation of the accelerating structure also generates non-injected, sub-picosecond duration, 1–2 MeV nanocoulomb electron beams emitted obliquely into a hollow cone around the laser propagation axis. These wide-angle beams are stable and depend weakly on laser and plasma parameters. Here we perform simulations to characterise the coherent transition radiation emitted by these beams if passed through a thin metal foil, or directly at the plasma–vacuum interface, showing that coherent terahertz radiation with 10s μJ to mJ-level energy can be produced with an optical to terahertz conversion efficiency up to 10‑4–10‑3.

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer.

PubMed

Goddard, Erica T; Fischer, Jacob; Schedin, Pepper

2016-12-26

Breast cancer is the leading cause of cancer-related mortality in women worldwide. Liver metastasis is involved in upwards of 30% of cases with breast cancer metastasis, and results in poor outcomes with median survival rates of only 4.8 - 15 months. Current rodent models of breast cancer metastasis, including primary tumor cell xenograft and spontaneous tumor models, rarely metastasize to the liver. Intracardiac and intrasplenic injection models do result in liver metastases, however these models can be confounded by concomitant secondary-site metastasis, or by compromised immunity due to removal of the spleen to avoid tumor growth at the injection site. To address the need for improved liver metastasis models, a murine portal vein injection method that delivers tumor cells firstly and directly to the liver was developed. This model delivers tumor cells to the liver without complications of concurrent metastases in other organs or removal of the spleen. The optimized portal vein protocol employs small injection volumes of 5 - 10 μl, ≥ 32 gauge needles, and hemostatic gauze at the injection site to control for blood loss. The portal vein injection approach in Balb/c female mice using three syngeneic mammary tumor lines of varying metastatic potential was tested; high-metastatic 4T1 cells, moderate-metastatic D2A1 cells, and low-metastatic D2.OR cells. Concentrations of ≤ 10,000 cells/injection results in a latency of ~ 20 - 40 days for development of liver metastases with the higher metastatic 4T1 and D2A1 lines, and > 55 days for the less aggressive D2.OR line. This model represents an important tool to study breast cancer metastasis to the liver, and may be applicable to other cancers that frequently metastasize to the liver including colorectal and pancreatic adenocarcinomas.

Fault reactivation by fluid injection considering permeability evolution in fault-bordering damage zones

NASA Astrophysics Data System (ADS)

Yang, Z.; Yehya, A.; Rice, J. R.; Yin, J.

2017-12-01

Earthquakes can be induced by human activity involving fluid injection, e.g., as wastewater disposal from hydrocarbon production. The occurrence of such events is thought to be, mainly, due to the increase in pore pressure, which reduces the effective normal stress and hence the strength of a nearby fault. Change in subsurface stress around suitably oriented faults at near-critical stress states may also contribute. We focus on improving the modeling and prediction of the hydro-mechanical response due to fluid injection, considering the full poroelastic effects and not solely changes in pore pressure in a rigid host. Thus we address the changes in porosity and permeability of the medium due to the changes in the local volumetric strains. Our results also focus on including effects of the fault architecture (low permeability fault core and higher permeability bordering damage zones) on the pressure diffusion and the fault poroelastic response. Field studies of faults have provided a generally common description for the size of their bordering damage zones and how they evolve along their direction of propagation. Empirical laws, from a large number of such observations, describe their fracture density, width, permeability, etc. We use those laws and related data to construct our study cases. We show that the existence of high permeability damage zones facilitates pore-pressure diffusion and, in some cases, results in a sharp increase in pore-pressure at levels much deeper than the injection wells, because these regions act as conduits for fluid pressure changes. This eventually results in higher seismicity rates. By better understanding the mechanisms of nucleation of injection-induced seismicity, and better predicting the hydro-mechanical response of faults, we can assess methodologies and injection strategies to avoid risks of high magnitude seismic events. Microseismic events occurring after the start of injection are very important indications of when injection should be stopped and how to avoid major events. Our work contributes to the assessment or mitigation of seismic hazard and risk, and our long-term target question is: How to not make an earthquake?

Prospects of in vivo singlet oxygen luminescence monitoring: Kinetics at different locations on living mice.

PubMed

Pfitzner, Michael; Schlothauer, Jan C; Bastien, Estelle; Hackbarth, Steffen; Bezdetnaya, Lina; Lassalle, Henri-Pierre; Röder, Beate

2016-06-01

Singlet oxygen observation is considered a valuable tool to assess and optimize PDT treatment. In complex systems, such as tumors in vivo, only the direct, time-resolved singlet oxygen luminescence detection can give reliable information about generation and interaction of singlet oxygen. Up to now, evaluation of kinetics was not possible due to insufficient signal-to-noise ratio. Here we present high signal-to-noise ratio singlet oxygen luminescence kinetics obtained in mouse tumor model under PDT relevant conditions. A highly optimized system based on a custom made laser diode excitation source and a high aperture multi-furcated fiber, utilizing a photomultiplier tube with a multi photon counting device was used. Luminescence kinetics with unsurpassed signal-to-noise ratio were gained from tumor bearing nude mice in vivo upon topic application, subcutaneous injection as well as intravenous injection of different photosensitizers (chlorin e6 and dendrimer formulations of chlorin e6). Singlet oxygen kinetics in appropriate model systems are discussed to facilitate the interpretation of complex kinetics obtained from in vivo tumor tissue. This is the first study addressing the complexity of singlet oxygen luminescence kinetics in tumor tissue. At present, further investigations are needed to fully explain the processes involved. Nevertheless, the high signal-to-noise ratio proves the applicability of direct time-resolved singlet oxygen luminescence detection as a prospective tool for monitoring photodynamic therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

Injection locking of optomechanical oscillators via acoustic waves.

PubMed

Huang, Ke; Hossein-Zadeh, Mani

2018-04-02

Injection locking is an effective technique for synchronization of oscillator networks and controlling the phase and frequency of individual oscillators. As such, exploring new mechanisms for injection locking of emerging oscillators is important for their usage in various systems. Here, we present the first demonstration of injection locking of a radiation pressure driven optomechanical oscillator (OMO) via acoustic waves. As opposed to previously reported techniques (based on pump modulation or direct application of a modulated electrostatic force), injection locking of OMO via acoustic waves does not require optical power modulation or physical contact with the OMO and it can be easily implemented on various platforms to lock different types of OMOs independent of their size and structure. Using this approach we have locked the phase and frequency of two distinct modes of a microtoroidal silica OMO to a piezoelectric transducer (PZT). We have characterized the behavior of the injection locked OMO with three acoustic excitation configurations and showed that even without proper acoustic impedance, matching the OMO can be locked to the PZT and tuned over 17 kHz with only -30 dBm of RF power fed to the PZT. The high efficiency, simplicity, and scalability of the proposed approach paves the road toward a new class of photonic systems that rely on synchronization of several OMOs to a single or multiple RF oscillators with applications in optical communication, metrology, and sensing. Beyond its practical applications, injection locking via acoustic waves can be used in fundamental studies in quantum optomechanics where thermal and optical isolation of the OMO are critical.

Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System

PubMed Central

Cai, Xiang; Walgenbach, Martin; Doerpmond, Malte; Schulze Lammers, Peter; Sun, Yurui

2016-01-01

To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input–output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy. PMID:26805833

Evaluation of the acute and chronic safety of the biosense injection catheter system in porcine hearts.

PubMed

Kornowski, R; Fuchs, S; Tio, F O; Pierre, A; Epstein, S E; Leon, M B

1999-12-01

Direct myocardial injection of therapeutic agents has been explored as a new method for myocardial revascularization. The integration of a 3D electromechanical mapping catheter with a retractable injection needle should allow for intramyocardial injection to identified sites, obviating the need for open heart surgery. This study assessed the procedural safety and performance characteristics of a novel guided catheter-based transendocardial injection system. The electromagnetic guidance system was coupled with a retrievable 27G needle for left ventricular endocardial injection. Using this system, we injected, transendocardially, methylene-blue (MB) dye tracer at a volume of 0.1 or 0.2 ml per injection in eight normal pigs. Animals were sacrificed acutely, at 1, 3, and 7 days (two animal in each time). Three animals served as controls. The injections were followed by coronary angiography and echocardiogram to assess possible ventricular or coronary perforation and wall motion abnormalities. CK-MB levels were measured up to 24 hr following the procedure. The animals were sacrificed at the assigned time for gross and histopathology evaluation. A total of 101 injections were made in all regions of the heart except the apex and the mitral valve. No animal died as a result of the mapping or injection procedures. Vital signs did not change relative to baseline after the mapping and injection procedures. CK-MB values did not increase over time and there was no evidence of sustained arrhythmia or hemodynamic compromise. There was no evidence of left ventricular or coronary perforation, global or regional wall motion abnormalities, or hemopericardium. On histologic evaluation, the estimated volume of tissue staining was greater than the volume of the injected MB dye due to dispersion of the injectate in the interstitial and intracellular fluid compartments. It is concluded that using this magnetic guidance catheter-based navigational system, it is feasible and safe to perform the transendocardial injection procedure. Thus, if it is determined that direct intramyocardial injection of drugs is a valid therapeutic strategy, this approach offers a clear advantage over surgically based transepicardial injection procedures. Cathet. Cardiovasc. Intervent. 48:447-453, 1999. Copyright 1999 Wiley-Liss, Inc.

Investigation of beam- and wave-plasma interactions in spherical tokamak Globus-M

NASA Astrophysics Data System (ADS)

Gusev, V. K.; Aminov, R. M.; Berezutskiy, A. A.; Bulanin, V. V.; Chernyshev, F. V.; Chugunov, I. N.; Dech, A. V.; Dyachenko, V. V.; Ivanov, A. E.; Khitrov, S. A.; Khromov, N. A.; Kurskiev, G. S.; Larionov, M. M.; Melnik, A. D.; Minaev, V. B.; Mineev, A. B.; Mironov, M. I.; Miroshnikov, I. V.; Mukhin, E. E.; Novokhatsky, A. N.; Panasenkov, A. A.; Patrov, M. I.; Petrov, A. V.; Petrov, Yu. V.; Podushnikova, K. A.; Rozhansky, V. A.; Rozhdestvensky, V. V.; Sakharov, N. V.; Shevelev, A. E.; Senichenkov, I. Yu.; Shcherbinin, O. N.; Stepanov, A. Yu.; Tolstyakov, S. Yu.; Varfolomeev, V. I.; Voronin, A. V.; Yagnov, V. A.; Yashin, A. Yu.; Zhilin, E. G.

2011-10-01

The experimental and theoretical results obtained in the last two years on the interaction of neutral particle beams and high-frequency waves with a plasma using the spherical tokamak Globus-M are discussed. The experiments on the injection of low-energy proton beam of ~300 eV directed particle energy are performed with a plasma gun that produces a hydrogen plasma jet of density up to 3 × 1022 m-3 and a high velocity up to 250 km s-1. A moderate density rise (up to 30%) is achieved in the central plasma region without plasma disruption. Experiments on high-energy (up to 30 keV) neutral beam injection into the D-plasma are analysed. Modelling results on confinement of fast particles inside the plasma column that follows the neutral beam injection are discussed. The influence of the magnetic field on the fast particle losses is argued. A neutral beam injection regime with primary ion heating is obtained and discussed. The new regime with fast current ramp-up and early neutral beam injection shows electron temperature rise and formation of broad Te profiles until the q = 1 flux surface enters the plasma column. An energetic particle mode in the range of frequencies 5-30 kHz and toroidal Alfvén eigenmodes in the range 50-300 kHz are recorded in that regime simultaneously with the Te rise. The energetic particle mode and toroidal Alfvén eigenmodes behaviour are discussed. The toroidal Alfvén eigenmode spectrum appears in Globus-M as a narrow band corresponding to n = 1. The first experimental results on plasma start-up and noninductive current drive generation are presented. The experiments are carried out with antennae providing mostly poloidal slowing down of waves with a frequency of 920 MHz, which is higher than a lower hybrid one existing under the experimental conditions. The high current drive efficiency is shown to be high (of about 0.25 A W-1), and its mechanism is proposed. Some near future plans of the experiments are also discussed.

Factors in the Design of Centrifugal Type Injection Valves for Oil Engines

NASA Technical Reports Server (NTRS)

Joachim, W F; Beardsley, E G

1928-01-01

This research was undertaken in connection with a general study of the application of the fuel injection engine to aircraft. The purpose of the investigation was to determine the effect of four important factors in the design of a centrifugal type automatic injection valve on the penetration, general shape, and distribution of oil sprays. The general method employed was to record the development of single sprays by means of special high-speed photographic apparatus capable of taking 25 consecutive pictures of the moving spray at a rate of 4,000 per second. Investigations were made concerning the effects on spray characteristics, of the helix angle of helical grooves, the ratio of the cross-sectional area of the orifice to that of the grooves, the ratio of orifice length to diameter, and the position of the seat. Maximum spray penetration was obtained with a ratio of orifice length to diameter of about 1.5. Slightly greater penetration was obtained with the seat directly before the orifice.

Spin injection and inverse Edelstein effect in the surface states of topological Kondo insulator SmB6

PubMed Central

Song, Qi; Mi, Jian; Zhao, Dan; Su, Tang; Yuan, Wei; Xing, Wenyu; Chen, Yangyang; Wang, Tianyu; Wu, Tao; Chen, Xian Hui; Xie, X. C.; Zhang, Chi; Shi, Jing; Han, Wei

2016-01-01

There has been considerable interest in exploiting the spin degrees of freedom of electrons for potential information storage and computing technologies. Topological insulators (TIs), a class of quantum materials, have special gapless edge/surface states, where the spin polarization of the Dirac fermions is locked to the momentum direction. This spin–momentum locking property gives rise to very interesting spin-dependent physical phenomena such as the Edelstein and inverse Edelstein effects. However, the spin injection in pure surface states of TI is very challenging because of the coexistence of the highly conducting bulk states. Here, we experimentally demonstrate the spin injection and observe the inverse Edelstein effect in the surface states of a topological Kondo insulator, SmB6. At low temperatures when only surface carriers are present, a clear spin signal is observed. Furthermore, the magnetic field angle dependence of the spin signal is consistent with spin–momentum locking property of surface states of SmB6. PMID:27834378

Helical bottleneck effect in 3D homogeneous isotropic turbulence

NASA Astrophysics Data System (ADS)

Stepanov, Rodion; Golbraikh, Ephim; Frick, Peter; Shestakov, Alexander

2018-02-01

We present the results of modelling the development of homogeneous and isotropic turbulence with a large-scale source of energy and a source of helicity distributed over scales. We use the shell model for numerical simulation of the turbulence at high Reynolds number. The results show that the helicity injection leads to a significant change in the behavior of the energy and helicity spectra in scales larger and smaller than the energy injection scale. We suggest the phenomenology for direct turbulent cascades with the helicity effect, which reduces the efficiency of the spectral energy transfer. Therefore the energy is accumulated and redistributed so that non-linear interactions will be sufficient to provide a constant energy flux. It can be interpreted as the ‘helical bottleneck effect’ which, depending on the parameters of the injection helicity, reminds one of the well-known bottleneck effect at the end of inertial range. Simulations which included the infrared part of the spectrum show that the inverse cascade hardly develops under distributed helicity forcing.

Spin injection and inverse Edelstein effect in the surface states of topological Kondo insulator SmB 6

DOE PAGES

Song, Qi; Mi, Jian; Zhao, Dan; ...

2016-11-11

There has been considerable interest in exploiting the spin degrees of freedom of electrons for potential information storage and computing technologies. Topological insulators (TIs), a class of quantum materials, have special gapless edge/surface states, where the spin polarization of the Dirac fermions is locked to the momentum direction. This spin–momentum locking property gives rise to very interesting spin-dependent physical phenomena such as the Edelstein and inverse Edelstein effects. However, the spin injection in pure surface states of TI is very challenging because of the coexistence of the highly conducting bulk states. Here, we experimentally demonstrate the spin injection and observemore » the inverse Edelstein effect in the surface states of a topological Kondo insulator, SmB 6. At low temperatures when only surface carriers are present, a clear spin signal is observed. Moreover, the magnetic field angle dependence of the spin signal is consistent with spin–momentum locking property of surface states of SmB6.« less

Numerical investigation on cryogenic liquid jet under transcritical and supercritical conditions

NASA Astrophysics Data System (ADS)

Li, Liang; Xie, Maozhao; Wei, Wu; Jia, Ming; Liu, Hongsheng

2018-01-01

Cryogenic fluid injection and mixing under transcritical and supercritical conditions is numerically investigated with emphasis on the difference of the mechanism and characteristics between the two injections. A new solver is developed which is capable of handling the nonideality of the equation of state and the anomalies in fluid transport properties and is incorporated into the CFD software OpenFOAM. The new solver has been validated against available experimental data and exhibits a good performance. Computational results indicates that the differences between transcritical and supercritical injections are mainly induced by the pseudo-boiling phenomenon, resulting in that the transcritical jet has a longer cold liquid core and an isothermal expansion occurs at the surface of the cold core. The thickness of the supercritical mixing layer and its increase value along the jet direction are greater than its transcritical counterpart. The high-temperature jet whose initial temperature is above the pseudo-boiling temperature has the ability of enhancing the mixing of the jet with the surrounding gas.

Effect of sodium aurothiomalate on carrageenan induced inflammation of the air pouch in mice.

PubMed Central

Sin, Y M; Wong, M K

1992-01-01

Acute inflammation was induced by injecting carrageenan into a 6 day old air pouch in mice. Sodium aurothiomalate was then given twice to each of three groups of mice via different routes. It was found that the mice injected intravenously with sodium aurothiomalate showed the most striking reduction in the number of exudate leucocytes in the inflammatory cavity, although the amount of gold found in their inflamed pouch lining tissue was the least. The amount of gold in plasma was highest in the mice injected intravenously with sodium aurothiomalate and the least amount of gold was found in the mice injected directly into the air pouch with sodium aurothiomalate. The amount of gold in the inflamed pouch lining tissue reached its peak at 24 hours after injection and a significant decrease of exudate leucocytes was only seen 24 and 72 hours after injection. The amount of gold in the exudate fluid was negligible at all the times studied. No significant difference was noted in the degree of inflammatory suppression when increasing doses of sodium aurothiomalate were injected into the air pouch. These findings show that there is no direct correlation between the gold concentration in the inflamed tissue and suppression of the inflammatory reactions in the cavity. Chemotactic and phagocytic analysis of leucocytes in the exudate showed that there was a significant suppression of the neutrophil activities in all the mice treated with sodium aurothiomalate. It is therefore concluded that the significant reduction in the number of exudate leucocytes at the carrageenan induced inflammatory site after treatment with sodium aurothiomalate is most likely due to the direct action of gold on the functional activities of circulating neutrophils. Images PMID:1540014

Laparoendoscopic transgastric histoacryl injection of gastric varices: a new surgical approach.

PubMed

Kassem, Mohamed I; El-Haddad, Hani M; El-Bahrawi, Hassan A

2013-02-01

Gastric varices (GVs) are a common finding in Egyptian patients with portal hypertension due to cirrhosis or schistosomal hepatic fibrosis. These patients present with an acute attack or history of hematemesis. Endoscopic histoacryl injection is the standard treatment in Egypt; however, because of technical difficulties it is possible to inject only a little amount of this material, as it may endanger the channels of the flexible endoscope. We thought of a new surgical laparoendoscopic technique to obviate the need for repeated endoscopies and complete obliteration of GVs. This study was conducted on 20 patients with portal hypertension and GVs. After the patient was placed under general anesthesia, a small gastrostomy was done in the anterior gastric wall through which a 10-mm trocar was inserted for the laparoscopic camera. Injection of GVs was done via a spinal needle or a central venous line needle inserted directly. Injection of an adequate amount of histoacryl was done under direct vision. This study was conducted from July 2009 to August 2011 on 20 patients with GVs. The age range was from 22 to 56 years, with a mean age of 39.8±7.85 years. There were 14 men (70%) and 6 women (30%). Fourteen patients (70%) showed complete obliteration of GVs after one session of treatment, whereas 6 patients (30%) had unsatisfactory results and were subjected to another session. GVs were completely obliterated after the second session in 4 patients. Two cases of recurrence of GVs were operated on. This new technique enabled us to inject GVs with a suitable amount of glue material under direct vision without harming the endoscope. Use of this procedure is recommended in patients fit for surgery and those who had failed endoscopic injection sclerotherapy.

High temperature corrosion of austenitic stainless steel coils in a direct reduction plant in Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juarez-Islas, J.A.; Campillo, B.; Chaudhary, N.

1996-08-01

The subject of this study is related to the performance of austenitic steels coils and tubes, in a range of temperatures between 425 to 870 C for the transport of reducing gases, in an installation involving the direct reduction of iron-ore by reforming natural gas. Evidence is presented that metal dusting is not the only unique high temperature corrosion mechanism that caused catastrophic failures of austenitic 304 (UNS S30400) coils and HK-40 (UNS J94204) tubes. Sensitization as well as stress corrosion cracking occurred in 304 stainless steel coils, and metal dusting occurred in tubes of HK-40, a high resistance alloy.more » The role of a continuous injection of H{sub 2}S to the process is suggested to avoid the high temperature metal dusting corrosion mechanism found in these kind of installations.« less

Effect of Injection Pressure of Infiltration Anesthesia to the Jawbone.

PubMed

Yoshida, Kenji; Tanaka, Eri; Kawaai, Hiroyoshi; Yamazaki, Shinya

To obtain effective infiltration anesthesia in the jawbone, high concentrations of local anesthetic are needed. However, to reduce pain experienced by patients during local anesthetic administration, low-pressure injection is recommended for subperiosteal infiltration anesthesia. Currently, there are no studies regarding the effect of injection pressure on infiltration anesthesia, and a standard injection pressure has not been clearly determined. Hence, the effect of injection pressure of subperiosteal infiltration anesthesia on local anesthetic infiltration to the jawbone was considered by directly measuring lidocaine concentration in the jawbone. Japanese white male rabbits were used as test animals. After inducing general anesthesia with oxygen and sevoflurane, cannulation to the femoral artery was performed and arterial pressure was continuously recorded. Subperiosteal infiltration anesthesia was performed by injecting 0.5 mL of 2% lidocaine containing 1/80,000 adrenaline, and injection pressure was monitored by a pressure transducer for 40 seconds. After specified time intervals (10, 20, 30, 40, 50, and 60 minutes), jawbone and blood samples were collected, and the concentration of lidocaine at each time interval was measured. The mean injection pressure was divided into 4 groups (100 ± 50 mm Hg, 200 ± 50 mm Hg, 300 ± 50 mm Hg, and 400 ± 50 mm Hg), and comparison statistical analysis between these 4 groups was performed. No significant change in blood pressure during infiltration anesthesia was observed in any of the 4 groups. Lidocaine concentration in the blood and jawbone were highest 10 minutes after the infiltration anesthesia in all 4 groups and decreased thereafter. Lidocaine concentration in the jawbone increased as injection pressure increased, while serum lidocaine concentration was significantly lower. This suggests that when injection pressure of subperiosteal infiltration anesthesia is low, infiltration of local anesthetic to the jawbone may be reduced, while transfer to oral mucosa and blood may be increased.

Effect of Injection Pressure of Infiltration Anesthesia to the Jawbone

PubMed Central

Yoshida, Kenji; Tanaka, Eri; Kawaai, Hiroyoshi; Yamazaki, Shinya

2016-01-01

To obtain effective infiltration anesthesia in the jawbone, high concentrations of local anesthetic are needed. However, to reduce pain experienced by patients during local anesthetic administration, low-pressure injection is recommended for subperiosteal infiltration anesthesia. Currently, there are no studies regarding the effect of injection pressure on infiltration anesthesia, and a standard injection pressure has not been clearly determined. Hence, the effect of injection pressure of subperiosteal infiltration anesthesia on local anesthetic infiltration to the jawbone was considered by directly measuring lidocaine concentration in the jawbone. Japanese white male rabbits were used as test animals. After inducing general anesthesia with oxygen and sevoflurane, cannulation to the femoral artery was performed and arterial pressure was continuously recorded. Subperiosteal infiltration anesthesia was performed by injecting 0.5 mL of 2% lidocaine containing 1/80,000 adrenaline, and injection pressure was monitored by a pressure transducer for 40 seconds. After specified time intervals (10, 20, 30, 40, 50, and 60 minutes), jawbone and blood samples were collected, and the concentration of lidocaine at each time interval was measured. The mean injection pressure was divided into 4 groups (100 ± 50 mm Hg, 200 ± 50 mm Hg, 300 ± 50 mm Hg, and 400 ± 50 mm Hg), and comparison statistical analysis between these 4 groups was performed. No significant change in blood pressure during infiltration anesthesia was observed in any of the 4 groups. Lidocaine concentration in the blood and jawbone were highest 10 minutes after the infiltration anesthesia in all 4 groups and decreased thereafter. Lidocaine concentration in the jawbone increased as injection pressure increased, while serum lidocaine concentration was significantly lower. This suggests that when injection pressure of subperiosteal infiltration anesthesia is low, infiltration of local anesthetic to the jawbone may be reduced, while transfer to oral mucosa and blood may be increased. PMID:27585416

Energetic Electron Acceleration, Injection, and Transport in Mercury's Magnetosphere

NASA Astrophysics Data System (ADS)

Dewey, R. M.; Slavin, J. A.; Raines, J. M.; Baker, D. N.; Lawrence, D. J.

2018-05-01

Electrons are accelerated in Mercury’s magnetotail by dipolarization events, flux ropes, and magnetic reconnection directly. Following energization, these electrons are injected close to Mercury where they drift eastward in Shabansky-like orbits.

Current instability and burnout of HEMT structures

NASA Astrophysics Data System (ADS)

Vashchenko, V. A.; Sinkevitch, V. F.

1996-06-01

The burnout mechanism and region of high conductivity formation under breakdown of pseudomorphic GalnAs/GaAlAs and GaAs/GaAlAs HEMT structures have been studied in a pulsed and direct current (d.c.) regime. Peculiarities of the HEMT breakdown have been compared with a GaAs MESFET structure of the same topology. It appears that in all types of investigated structures the drain voltage increase is limited by the transition into a high conductivity state as a result of "parasitic" avalanche-injection conductivity modulation of the undoped GaAs or i-GaAs layer. It has been established that the transition into a high conductivity state is caused by holes from the drain avalanche region in the channel and is the result of a mutual intensification of the avalanche generation rate near the drain and the injection level from the source contact. It turns out that under a typical gate bias operation the transition in the high conductivity state is accompanied by a negative differential conductivity (NDC) and results in the formation of high current density filaments. The resulting high local overheating in the filament region is the cause of local melting and burnout of the HEMT structures.

Numerical prediction of flow induced fibers orientation in injection molded polymer composites

NASA Astrophysics Data System (ADS)

Oumer, A. N.; Hamidi, N. M.; Mat Sahat, I.

2015-12-01

Since the filling stage of injection molding process has important effect on the determination of the orientation state of the fibers, accurate analysis of the flow field for the mold filling stage becomes a necessity. The aim of the paper is to characterize the flow induced orientation state of short fibers in injection molding cavities. A dog-bone shaped model is considered for the simulation and experiment. The numerical model for determination of the fibers orientation during mold-filling stage of injection molding process was solved using Computational Fluid Dynamics (CFD) software called MoldFlow. Both the simulation and experimental results showed that two different regions (or three layers of orientation structures) across the thickness of the specimen could be found: a shell region which is near to the mold cavity wall, and a core region at the middle of the cross section. The simulation results support the experimental observations that for thin plates the probability of fiber alignment to the flow direction near the mold cavity walls is high but low at the core region. It is apparent that the results of this study could assist in decisions regarding short fiber reinforced polymer composites.

Occupational hazards of traditional healers: repeated unprotected blood exposures risk infectious disease transmission.

PubMed

Audet, Carolyn M; Salato, José; Blevins, Meridith; Silva, Wilson; González-Calvo, Lázaro; Vermund, Sten H; Gaspar, Felisbela

2016-11-01

Healers provide support for acute and chronic illnesses in rural Mozambique, such as socially acceptable traditional 'vaccinations' (subcutaneous cuts in the skin to rub herbs directly into the bloody lesion). We aimed to document the frequency of blood exposure by traditional practitioners in Mozambique. We conducted surveys with a simple random sample of 236 traditional healers in Zambézia province. Chi-square and Wilcoxon rank-sum tests were used to compare 'injection' behaviours across districts. Healers treated a median of eight patients in the past month (IQR: 4-15). About 75% conducted 'injections'. These healers 'injected' a median of four patients (IQR: 1-8), used a new razor a median of three times (IQR: 1-8), and almost never used gloves. Lifetime blood exposures among those who provided 'injections' during treatments were estimated to be 1758 over a healer's career. The majority of healers are exposed repeatedly to patient blood. Given the high prevalence of HIV, hepatitis B and C virus, and other blood-borne agents, specific healer practices are an occupational hazard and reuse of razors is risky for their clients. © 2016 John Wiley & Sons Ltd.

Autonomous replication and addition of telomerelike sequences to DNA microinjected into Paramecium tetraurelia macronuclei.

PubMed Central

Gilley, D; Preer, J R; Aufderheide, K J; Polisky, B

1988-01-01

Paramecium tetraurelia can be transformed by microinjection of cloned serotype A gene sequences into the macronucleus. Transformants are detected by their ability to express serotype A surface antigen from the injected templates. After injection, the DNA is converted from a supercoiled form to a linear form by cleavage at nonrandom sites. The linear form appears to replicate autonomously as a unit-length molecule and is present in transformants at high copy number. The injected DNA is further processed by the addition of paramecium-type telomeric sequences to the termini of the linear DNA. To examine the fate of injected linear DNA molecules, plasmid pSA14SB DNA containing the A gene was cleaved into two linear pieces, a 14-kilobase (kb) piece containing the A gene and flanking sequences and a 2.2-kb piece consisting of the procaryotic vector. In transformants expressing the A gene, we observed that two linear DNA species were present which correspond to the two species injected. Both species had Paramecium telomerelike sequences added to their termini. For the 2.2-kb DNA, we show that the site of addition of the telomerelike sequences is directly at one terminus and within one nucleotide of the other terminus. These results indicate that injected procaryotic DNA is capable of autonomous replication in Paramecium macronuclei and that telomeric addition in the macronucleus does not require specific recognition sequences. Images PMID:3211128

Fracturing of porous rock induced by fluid injection

NASA Astrophysics Data System (ADS)

Stanchits, Sergei; Mayr, Sibylle; Shapiro, Serge; Dresen, Georg

2011-04-01

We monitored acoustic emission (AE) activity and brittle failure initiated by water injection into initially dry critically stressed cylindrical specimens of Flechtingen sandstone of 50 mm diameter and 105-125 mm length. Samples were first loaded in axial direction at 40-50 MPa confining pressure at dry conditions close to peak stress. Subsequently distilled water was injected either at the bottom of specimen or via a central borehole at pore pressures of 5-30 MPa. Water injection into stressed porous sandstone induced a cloud of AE events located close to the migrating water front. Water injection was monitored by periodic ultrasonic velocity measurements across the sample. Propagation of the induced cloud of AE was faster in the direction parallel to bedding than normal to it, indicating permeability anisotropy. Water injection was associated with significant AE activity demonstrating increased contribution of tensile source type. Brittle failure was accompanied by increased contribution of shear and pore collapse source types. At a critical pore pressure, a brittle fault nucleated from a cloud of induced AE events in all samples. Microstructural analysis of fractured samples shows excellent agreement between location of AE hypocenters and macroscopic faults.

Development of Advanced Low Emission Injectors and High-Bandwidth Fuel Flow Modulation Valves

NASA Technical Reports Server (NTRS)

Mansour, Adel

2015-01-01

Parker Hannifin Corporation developed the 3-Zone fuel nozzle for NASA's Environmentally Responsible Aviation Program to meet NASAs target of 75 LTO NOx reduction from CAEP6 regulation. The nozzle concept was envisioned as a drop-in replacement for currently used fuel nozzle stem, and is built up from laminates to provide energetic mixing suitable for lean direct injection mode at high combustor pressure. A high frequency fuel valve was also developed to provide fuel modulation for the pilot injector. Final testing result shows the LTO NOx level falling just shy of NASAs goal at 31.

Foliar residue dynamics of azadirachtins following direct stem injection into white and green ash trees for control of emerald ash borer.

PubMed

Grimalt, Susana; Thompson, Dean; Chartrand, Derek; McFarlane, John; Helson, Blair; Lyons, Barry; Meating, Joe; Scarr, Taylor

2011-10-01

Azadirachtins are natural insecticides derived from the neem tree. The emerald ash borer (EAB) is an exotic invasive insect pest that infests various ash tree species and has the potential for significant economic, aesthetic and ecological impacts throughout North America. The initial translocation and foliar residue dynamics of azadirachtins were examined following direct injection into white and green ash trees growing in urban scenarios as a potential control for EAB. Substantial concentrations of azadirachtins A and B [mean maxima > 0.98 mg kg(-1) fresh weight (f.w.)] were observed within 2 days of injecting a specifically designed formulation of azadirachtins. Foliar residues declined exponentially through time, with half-life estimates ranging from 5.1 to 12.3 days. At the time of leaf senescence, foliar residue levels approximated 0.01 mg kg(-1) f.w., strongly mitigating the potential effects of non-target biota in soil or aquatic compartments. The magnitude and duration of exposures observed in this field study were considered to be above the thresholds required for biological effectiveness against both larval and adult life stages of EAB. Results support the use of azadirachtins as an environmentally acceptable systemic insecticide for control of EAB and protection of high-value ash trees in urban environments. Copyright © 2011 Society of Chemical Industry.

Multifuel rotary aircraft engine

NASA Technical Reports Server (NTRS)

Jones, C.; Berkowitz, M.

1980-01-01

The broad objectives of this paper are the following: (1) to summarize the Curtiss-Wright design, development and field testing background in the area of rotary aircraft engines; (2) to briefly summarize past activity and update development work in the area of stratified charge rotary combustion engines; and (3) to discuss the development of a high-performance direct injected unthrottled stratified charge rotary combustion aircraft engine. Efficiency improvements through turbocharging are also discussed.

Advanced rotary engines

NASA Technical Reports Server (NTRS)

Jones, C.

1983-01-01

The broad objectives of this paper are the following: (1) to summarize the Curtiss-Wright design, development and field testing background in the area of rotary aircraft engines; (2) to briefly summarize past activity and update development work in the area of stratified charge rotary combustion engines; and (3) to discuss the development of a high-performance direct injected unthrottled stratified charge rotary combustion aircraft engine. Efficiency improvements through turbocharging are also discussed.

Distribution of naloxone for overdose prevention to chronic pain patients.

PubMed

Coe, Marion A; Walsh, Sharon L

2015-11-01

In this commentary, we reflect on the growing opioid overdose epidemic and propose that chronic pain patients prescribed opioids are contributing to growing mortality rates. We advocate for expanding naloxone access and overdose prevention training, which has historically been directed when available to injection drug users, to chronic pain patients who may be at high risk for accidental opioid overdose. Copyright © 2015 Elsevier Inc. All rights reserved.

Direct gas injection method: A simple modification to an elemental analyzer/isotope ratio mass spectrometer for stable isotope analysis of N and C from N2O and CO2 gases in nanomolar concentrations

EPA Science Inventory

A simple modification to the Elemental Analyzer coupled to Isotope Ratio Mass-Spectrometer (EA-IRMS) setup is described. This modification allows the users to measure nitrous oxide (N2O) and carbon dioxide (CO2) by injecting the gases directly into an online injector placed befor...

Ultrasound extracted flavonoids from four varieties of Portuguese red grape skins determined by reverse-phase high-performance liquid chromatography with electrochemical detection.

PubMed

Novak, Ivana; Janeiro, Patricia; Seruga, Marijan; Oliveira-Brett, Ana Maria

2008-12-23

Several flavonoids present in red grape skins from four varieties of Portuguese grapes were determined by reverse-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection (ECD). Extraction of flavonoids from red grape skins was performed by ultrasonication, and hydrochloric acid in methanol was used as extraction solvent. The developed RP-HPLC method used combined isocratic and gradient elution with amperometric detection with a glassy carbon-working electrode. Good peak resolution was obtained following direct injection of a sample of red grape extract in a pH 2.20 mobile phase. Eleven different flavonoids: cyanidin-3-O-glucoside (kuromanin), delphinidin-3-O-glucoside (myrtillin), petunidin-3-O-glucoside, peonidin-3-O-glucoside, malvidin-3-O-glucoside (oenin), (+)-catechin, rutin, fisetin, myricetin, morin and quercetin, can be separated in a single run by direct injection of sample solution. The limit of detection obtained for these compounds by ECD was 20-90 pg/L, 1000 times lower when compared with photodiode array (PDA) limit of detection of 12-55 ng/L. RP-HPLC-ECD was characterized by an excellent sensitivity and selectivity, and appropriate for the simultaneous determination of these electroactive phenolic compounds present in red grape skins.

A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS.

PubMed

Rainville, Paul D; Simeone, Jennifer L; Root, Dan S; Mallet, Claude R; Wilson, Ian D; Plumb, Robert S

2015-03-21

The emergence of micro sampling techniques holds great potential to improve pharmacokinetic data quality, reduce animal usage, and save costs in safety assessment studies. The analysis of these samples presents new challenges for bioanalytical scientists, both in terms of sample processing and analytical sensitivity. The use of two dimensional LC/MS with, at-column-dilution for the direct analysis of highly organic extracts prepared from biological fluids such as dried blood spots and plasma is demonstrated. This technique negated the need to dry down and reconstitute, or dilute samples with water/aqueous buffer solutions, prior to injection onto a reversed-phase LC system. A mixture of model drugs, including bromhexine, triprolidine, enrofloxacin, and procaine were used to test the feasibility of the method. Finally an LC/MS assay for the probe pharmaceutical rosuvastatin was developed from dried blood spots and protein-precipitated plasma. The assays showed acceptable recovery, accuracy and precision according to US FDA guidelines. The resulting analytical method showed an increase in assay sensitivity of up to forty fold as compared to conventional methods by maximizing the amount loaded onto the system and the MS response for the probe pharmaceutical rosuvastatin from small volume samples.

Comparative studies on the performance and emissions of a direct injection diesel engine fueled with neem oil and pumpkin seed oil biodiesel with and without fuel preheater.

PubMed

Ramakrishnan, Muneeswaran; Rathinam, Thansekhar Maruthu; Viswanathan, Karthickeyan

2018-02-01

In the present experimental analysis, two non-edible oils namely neem oil and pumpkin seed oil were considered. They are converted into respective biodiesels namely neem oil methyl ester (B1) and pumpkin seed oil methyl ester (B2) through transesterification process and their physical and chemical properties were examined using ASTM standards. Diesel was used as a baseline fuel in Kirloskar TV1 model direct injection four stroke diesel engine. A fuel preheater was designed and fabricated to operate at various temperatures (60, 70, and 80 °C). Diesel showed higher brake thermal efficiency (BTE) than biodiesel samples. Lower brake specific fuel consumption (BSFC) was obtained with diesel than B1 sample. B1 exhibited lower BSFC than B2 sample without preheating process. High preheating temperature (80 °C) results in lower fuel consumption for B1 sample. The engine emission characteristics like carbon monoxide (CO), hydrocarbon (HC), and smoke were found lower with B1 sample than diesel and B2 except oxides of nitrogen (NOx) emission. In preheating of fuel, B1 sample with high preheating temperature showed lower CO, HC, and smoke emission (except NOx) than B2 sample.

Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen.

PubMed

KING, M K; WOOD, W B

1958-02-01

By means of a method designed to compare the febrile responses produced by intracarotid and intravenous injections, the endogenous pyrogen, which is contained in leucocytic exudates and is present in the serum of rabbits 2 hours after intravenous injections of typhoid vaccine, has been shown to act directly upon the thermoregulatory centers of the brain. In contrast, the exogenous bacterial pyrogen present in serum obtained 5 minutes after vaccine injections was found to act by a different and less direct mechanism. These observations add strong support to the original hypothesis that endogenous pyrogen, presumably derived from polymorphonuclear leucocytes, is an essential factor in the pathogenesis of endotoxin fever.

High-accuracy measurements of N2O concentration and site-specific nitrogen isotopes in small or high concentration samples

NASA Astrophysics Data System (ADS)

Palmer, M. R.; Arata, C.; Huang, K.

2014-12-01

Nitrous oxide (N2O) gas is among the major contributors to global warming and ozone depletion in stratosphere. Quantitative estimate of N­2O production in various pathways and N­2O fluxes across different reservoirs is the key to understanding the role of N­2O in the global change. To achieve this goal, accurate and concurrent measurement of both N2O concentration ([N2O]) and its site-specific isotopic composition (SP-δ15N), namely δ15Nα and δ15Nβ, is desired. Recent developments in Cavity Ring-Down Spectroscopy (CRDS) have enabled high precision measurements of [N2O] and SP-δ15N of a continuous gas flow. However, many N­­2O samples are discrete with limited volume (< 500 ml), and/or high [N2O] (> 2 ppm), and are not suitable for direct measurements by CRDS. Here we present results of a Small Sample Isotope Module 2 (SSIM2) which is coupled to and automatically coordinated with a Picarro isotopic N2O CRDS analyzer to handle and measure high concentration and/or small volume samples. The SSIM2 requires 20 ml of sample per analysis, and transfers the sample to the CRDS for high precision measurement. When the sample injection is < 20 ml, a zero gas is optionally filled to make up the volume. We used the SSIM2 to dilute high [N2O] samples and < 20 ml samples, and tested the effect of dilution on the measured SP-δ15N. In addition, we employed and tested a newly developed double injection method for samples adequate for two 20 ml injections. After the SSIM2 and the CRDS cavity was primed with the first injection, the second injection, which has negligible dilution of the sample, can be accurately measured for both [N2O] and SP-δ15N. Results of these experiments indicate that the precision of SSIM2-CRDS is similar to that of the continuous measurements using the CRDS alone, and that dilution has minimal effect on SP-δ15N, as along as the [N2O] is > 300 ppb after dilution. Overall, the precision of SP-δ15N measured using the SSIM2 is < 0.5 ‰.

The influence of technological parameters on the dynamic behavior of "liquid wood" samples obtained by injection molding

NASA Astrophysics Data System (ADS)

Plavanescu Mazurchevici, Simona; Carausu, Constantin; Comaneci, Radu; Nedelcu, Dumitru

2017-10-01

The plastic products contribute to environmental pollution. Replacing the plastic materials with biodegradable materials with superior properties is an absolute necessity and important research direction for the near future. The first steps in this regard were the creation of composite materials containing natural fibers with positive effects on the environment that have penetrated in different fields. The bioplastics and biocomposites made from natural fibers is a topical solution. The next step was made towards obtaining biodegradable and recyclable materials based on cellulose, lignin and no carcinogens. In this category fall the "liquid wood" with a use up to five times without affecting the mechanical properties. "Liquid wood" is a high quality thermoplastic biocomposite. "Liquid wood" is a biopolymer composite divided in three categories, ARBOFORM®, ARBOBLEND® and ARBOFILL®, which have differed composition in terms of lignin percentage, being delivered by Tecnaro, as granules, [1]. The paper's research was focus on Arboform L V3 Nature and Arboform L V3 Nature reinforced with aramid fiber. In the experimental plan were taken into account six parameters (Dinj - direction of injection [°]; Ttop - melting temperature [°C]; Pinj - injection pressure [MPa] Ss - speed [m/min]; tinj - injection time [s] and tc - cooling time [s]) each with two levels, research carried on by Taguchi methodology. Processing Taguchi method allowed both Taguchi setting work parameters influence on storage modulus and damping as the size and influence their ranking. Experimental research concerning the influence technological parameters on storage modulus of samples obtained by injection from Arboform L V3 Nature yielded an average of 6055MPa and descending order as follows: Trac, Ss, Pinj, Dinj and Ttop. The average of model for reinforced material was 6419MPa and descending order of parameters influence such as: Dinj, Trac, Ttop, tinj, Ss and Pinj.

How Do Deep Saline Aquifer Microbial Communities Respond to Supercritical CO2 Injection?

NASA Astrophysics Data System (ADS)

Mu, A.; Billman-Jacobe, H.; Boreham, C.; Schacht, U.; Moreau, J. W.

2011-12-01

Carbon Capture and Storage (CCS) is currently seen as a viable strategy for mitigating anthropogenic carbon dioxide pollution. The Cooperative Research Centre for Greenhouse Gas Technologies (CO2CRC) is currently conducting a field experiment in the Otway Basin (Australia) studying residual gas saturation in the water-saturated reservoir of the Paaratte Formation. As part of this study, a suite of pre-CO2 injection water samples were collected from approximately 1400 meters depth (60°C, 13.8 MPa) via an in situ sampling system. The in situ sampling system isolates aquifer water from sources of contamination while maintaining the formation pressure. Whole community DNA was extracted from these samples to investigate the prokaryotic biodiversity of the saline Paaratte aquifer (EC = 1509.6 uS/cm). Bioinformatic analysis of preliminary 16S ribosomal gene data revealed Thermincola, Acinetobacter, Sphingobium, and Dechloromonas amongst the closest related genera to environmental clone sequences obtained from a subset of pre-CO2 injection groundwater samples. Epifluorescent microscopy with 4',6-diamidino-2-phenylindole (DAPI) highlighted an abundance of filamentous cells ranging from 5 to 45 μM. Efforts are currently directed towards utilising a high throughput sequencing approach to capture an exhaustive profile of the microbial diversity of the Paaratte aquifer CO2 injection site, and to understand better the response of in situ microbial populations to the injection of large volumes (e.g. many kilotonnes) of supercritical CO2 (sc-CO2). Sequencing results will be used to direct cultivation efforts towards enrichment of a CO2-tolerant microorganism. Understanding the microbial response to sc-CO2 is an integral aspect of carbon dioxide storage, for which very little information exists in the literature. This study aims to elucidate molecular mechanisms, through genomic and cultivation-based methods, for CO2 tolerance with the prospect of engineering biofilms to enhance trapping of CO2 in saline aquifers.

The anterior approach for a non-image-guided intra-articular hip injection.

PubMed

Mei-Dan, Omer; McConkey, Mark O; Petersen, Brian; McCarty, Eric; Moreira, Brett; Young, David A

2013-06-01

The purpose of this study was to investigate and validate the accuracy and safety of a technique using an anterior approach for non-image-guided intra-articular injection of the hip by use of anatomic landmarks. We enrolled 55 patients. Injections were performed before supine hip arthroscopy after landmarking and before application of traction. After the needle insertion, success was confirmed with an air arthrogram and by direct visualization after arthroscope insertion. Accuracy and difficulty achieving correct needle placement were correlated with age, weight, height, body mass index, body type, gender, and surgical indication, as well as femoral and pelvic morphology. Forty-five patients who underwent injection in the office were followed up separately to document injection side effects. Needle placement accuracy was correlated to patients' demographics. All statistical tests with P values were 2 sided, with the level of significance set at P < .05. There were 51 correct needle placements and 4 misses, yielding a 93% success rate. The most common location for needle placement was the upper medial head-neck junction. Female gender was correlated with a more difficult needle placement and misses in relation to group size (P = .06). The reasons for misplacements of the needle were a high-riding trochanter, increased femoral version, thick adipose tissue over the landmarks, and variant of ilium morphology. Of 45 patients in the side effect study arm, 3 reported sensory changes of the lateral femoral cutaneous nerve that resolved within 24 hours. Hip injections by use of the direct anterior approach, from the intersection of the lines drawn from the anterior superior iliac spine and 1 cm distal to the tip of the greater trochanter, are safe and reproducible. Patient characteristics, such as increased subcutaneous adipose tissue or osseous anatomic variants, can lead to difficulty in placing the needle successfully. These characteristics can be predicted with the aid of physical examination and careful study of the pelvic radiographs. Level IV, therapeutic case series. Copyright © 2013 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Neuromuscular Functions on Experimental Acute Methanol Intoxication.

PubMed

Moral, Ali Reşat; Çankayalı, İlkin; Sergin, Demet; Boyacılar, Özden

2015-10-01

The incidence of accidental or suicidal ingestion of methyl alcohol is high and methyl alcohol intoxication has high mortality. Methyl alcohol intoxication causes severe neurological sequelae and appears to be a significant problem. Methyl alcohol causes acute metabolic acidosis, optic neuropathy leading to permanent blindness, respiratory failure, circulatory failure and death. It is metabolised in the liver, and its metabolite formic acid has direct toxic effects, causing oxidative stress, mitochondrial damage and increased lipid peroxidation associated with the mechanism of neurotoxicity. Methanol is known to cause acute toxicity of the central nervous system; however, the effects on peripheral neuromuscular transmission are unknown. In our study, we aimed to investigate the electrophysiological effects of experimentally induced acute methanol intoxication on neuromuscular transmission in the early period (first 24 h). After approval by the Animal Experiment Ethics Committee of Ege University, the study was carried out on 10 Wistar rats, each weighing about 200 g. During electrophysiological recordings and orogastric tube insertion, the rats were anaesthetised using intra-peritoneal (IP) injection of ketamine 100 mg kg(-1) and IP injection of xylazine 10 mg kg(-1). The rats were given 3 g kg(-1) methyl alcohol by the orogastric tube. Electrophysiological measurements from the gastrocnemius muscle were compared with baseline. Latency measurements before and 24 h after methanol injection were 0.81±0.11 ms and 0.76±0.12 ms, respectively. CMAP amplitude measurements before and 24 h after methanol injection were 9.85±0.98 mV and 9.99±0.40 mV, respectively. CMAP duration measurements before and 24 h after methanol injection were 9.86±0.03 ms and 9.86±0.045 ms, respectively. It was concluded that experimental methanol intoxication in the acute phase (first 24 h) did not affect neuromuscular function.

Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

PubMed Central

Carroll, Marilyn E.; Zlebnik, Natalie E.; Anker, Justin J.; Kosten, Thomas R.; Orson, Frank M.; Shen, Xiaoyun; Kinsey, Berma; Parks, Robin J.; Gao, Yang; Brimijoin, Stephen

2012-01-01

Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH protein (1 mg/kg) had no effect on spontaneous locomotion, but it suppressed responses to i.p. cocaine up to 80 mg/kg. When CocH was injected i.p. along with a murine cocaine antiserum that also did not affect spontaneous locomotion, there was no response to any cocaine dose. This suppression of locomotor activity required active enzyme, as it was lost after pretreatment with iso-OMPA, a selective BChE inhibitor. Comparable results were obtained in rats that developed high levels of CocH by gene transfer with helper-dependent adenoviral vector, and/or high levels of anti-cocaine antibody by vaccination with norcocaine hapten conjugated to keyhole limpet hemocyanin (KLH). After these treatments, rats were subjected to a locomotor sensitization paradigm involving a “training phase" with an initial i.p. saline injection on day 1 followed by 8 days of repeated cocaine injections (10 mg/kg, i.p.). A 15-day rest period then ensued, followed by a final “challenge" cocaine injection. As in mice, the individual treatment interventions reduced cocaine-stimulated hyperactivity to a modest extent, while combined treatment produced a greater reduction during all phases of testing compared to control rats (with only saline pretreatment). Overall, the present results strongly support the view that anti-cocaine vaccine and cocaine hydrolase vector treatments together provide enhanced protection against the stimulatory actions of cocaine in rodents. A similar combination therapy in human cocaine users might provide a robust therapy to help maintain abstinence. PMID:22912888

Generation of a CW local oscillator signal using a stabilized injection locked semiconductor laser

NASA Astrophysics Data System (ADS)

Pezeshki, Jonah Massih

In high speed-communications, it is desirable to be able to detect small signals while maintaining a low bit-error rate. Conventional receivers for high-speed fiber optic networks are Amplified Direct Detectors (ADDs) that use erbium-doped fiber amplifiers (EDFAs) before the detector to achieve a suitable sensitivity. In principle, a better method for obtaining the maximum possible signal to noise ratio is through the use of homodyne detection. The major difficulty in implementing a homodyne detection system is the generation of a suitable local oscillator signal. This local oscillator signal must be at the same frequency as the received data signal, as well as be phase coherent with it. To accomplish this, a variety of synchronization techniques have been explored, including Optical Phase-Lock Loops (OPLL), Optical Injection Locking (OIL) with both Fabry-Perot and DFB lasers, and an Optical Injection Phase-Lock Loop (OIPLL). For this project I have implemented a method for regenerating a local oscillator from a portion of the received optical signal. This regenerated local oscillator is at the same frequency, and is phase coherent with, the received optical signal. In addition, we show that the injection locking process can be electronically stabilized by using the modulation transfer ratio of the slave laser as a monitor, given either a DFB or Fabry-Perot slave laser. We show that this stabilization technique maintains injection lock (given a locking range of ˜1GHz) for laser drift much greater than what is expected in a typical transmission system. In addition, we explore the quality of the output of the slave laser, and analyze its suitability as a local oscillator signal for a homodyne receiver.

Focused Schlieren flow visualization studies of multiple venturi fuel injectors in a high pressure combustor

NASA Technical Reports Server (NTRS)

Chun, K. S.; Locke, R. J.; Lee, C. M.; Ratvasky, W. J.

1994-01-01

Multiple venturi fuel injectors were used to obtain uniform fuel distributions, better atomization and vaporization in the premixing/prevaporizing section of a lean premixed/prevaporized flame tube combustor. A focused Schlieren system was used to investigate the fuel/air mixing effectiveness of various fuel injection configurations. The Schlieren system was focused to a plane within the flow field of a test section equipped with optical windows. The focused image plane was parallel to the axial direction of the flow and normal to the optical axis. Images from that focused plane, formed by refracted light due to density gradients within the flow field, were filmed with a high-speed movie camera at framing rates of 8,000 frames per second (fps). Three fuel injection concepts were investigated by taking high-speed movies of the mixture flows at various operating conditions. The inlet air temperature was varied from 600 F to 1000 F, and inlet pressures from 80 psia to 150 psia. Jet-A fuel was used typically at an equivalence ratio of 0.5. The intensity variations of the digitized Schlieren images were analytically correlated to spatial density gradients of the mixture flows. Qualitative measurements for degree of mixedness, intensity of mixing, and mixing completion time are shown. Various mixing performance patterns are presented with different configurations of fuel injection points and operating conditions.

Experimental evolution of insect immune memory versus pathogen resistance.

PubMed

Khan, Imroze; Prakash, Arun; Agashe, Deepa

2017-12-20

Under strong pathogen pressure, insects often evolve resistance to infection. Many insects are also protected via immune memory (immune priming), whereby sublethal exposure to a pathogen enhances survival after secondary infection. Theory predicts that immune memory should evolve when the pathogen is highly virulent, or when pathogen exposure is relatively rare. However, there are no empirical tests of these hypotheses, and the adaptive benefits of immune memory relative to direct resistance against a pathogen are poorly understood. To determine the selective pressures and ecological conditions that shape immune evolution, we imposed strong pathogen selection on flour beetle ( Tribolium castaneum ) populations, infecting them with Bacillus thuringiensis (Bt) for 11 generations. Populations injected first with heat-killed and then live Bt evolved high basal resistance against multiple Bt strains. By contrast, populations injected only with a high dose of live Bt evolved a less effective but strain-specific priming response. Control populations injected with heat-killed Bt did not evolve priming; and in the ancestor, priming was effective only against a low Bt dose. Intriguingly, one replicate population first evolved priming and subsequently evolved basal resistance, suggesting the potential for dynamic evolution of different immune strategies. Our work is the first report showing that pathogens can select for rapid modulation of insect priming ability, allowing hosts to evolve divergent immune strategies (generalized resistance versus specific immune memory) with potentially distinct mechanisms. © 2017 The Author(s).

Characterization of Diesel and Gasoline Compression Ignition Combustion in a Rapid Compression-Expansion Machine using OH* Chemiluminescence Imaging

NASA Astrophysics Data System (ADS)

Krishnan, Sundar Rajan; Srinivasan, Kalyan Kumar; Stegmeir, Matthew

2015-11-01

Direct-injection compression ignition combustion of diesel and gasoline were studied in a rapid compression-expansion machine (RCEM) using high-speed OH* chemiluminescence imaging. The RCEM (bore = 84 mm, stroke = 110-250 mm) was used to simulate engine-like operating conditions at the start of fuel injection. The fuels were supplied by a high-pressure fuel cart with an air-over-fuel pressure amplification system capable of providing fuel injection pressures up to 2000 bar. A production diesel fuel injector was modified to provide a single fuel spray for both diesel and gasoline operation. Time-resolved combustion pressure in the RCEM was measured using a Kistler piezoelectric pressure transducer mounted on the cylinder head and the instantaneous piston displacement was measured using an inductive linear displacement sensor (0.05 mm resolution). Time-resolved, line-of-sight OH* chemiluminescence images were obtained using a Phantom V611 CMOS camera (20.9 kHz @ 512 x 512 pixel resolution, ~ 48 μs time resolution) coupled with a short wave pass filter (cut-off ~ 348 nm). The instantaneous OH* distributions, which indicate high temperature flame regions within the combustion chamber, were used to discern the characteristic differences between diesel and gasoline compression ignition combustion. The authors gratefully acknowledge facilities support for the present work from the Energy Institute at Mississippi State University.

Controllable robust laser driven ion acceleration from near-critical density relativistic self-transparent plasma

NASA Astrophysics Data System (ADS)

Liu, Bin; Meyer-Ter-Vehn, Juergen; Ruhl, Hartmut

2017-10-01

We introduce an alternative approach for laser driven self-injected high quality ion acceleration. We call it ion wave breaking acceleration. It operates in relativistic self-transparent plasma for ultra-intense ultra-short laser pulses. Laser propagating in a transparent plasma excites an electron wave as well as an ion wave. When the ion wave breaks, a fraction of ions is self-injected into the positive part of the laser driven wake. This leads to a superior ion pulse with peaked energy spectra; in particular in realistic three-dimensional geometry, the injection occurs localized close to the laser axis producing highly directed bunches. A theory is developed to investigate the ion wave breaking dynamics. Three dimensional Particle-in-Cell simulations with pure-gaussian laser pulses and pre-expanded near-critical density plasma targets have been done to verify the theoretical results. It is shown that hundreds of MeV, easily controllable and manipulable, micron-scale size, highly collimated and quasi-mono-energetic ion beams can be produced by using ultra-intense ultra-short laser pulses with total laser energies less than 10 Joules. Such ion beams may find important applications in tumour therapy. B. Liu acknowledges support from the Alexander von Humboldt Foundation. B. Liu and H. Ruhl acknowledge supports from the Gauss Centre for Supercomputing (GCS), and the Cluster-of-Excellence Munich Centre for Advanced Photonics (MAP).

Experimental investigation on the performance, gaseous and particulate emissions of a methanol fumigated diesel engine.

PubMed

Cheng, C H; Cheung, C S; Chan, T L; Lee, S C; Yao, C D

2008-01-15

Experiments were conducted on a 4-cylinder direct-injection diesel engine with fumigation methanol injected into the air intake of each cylinder. The fumigation methanol was injected to top up 10%, 20% and 30% of the power output under different engine operating conditions. The effects of fumigation methanol on engine performance, gaseous emissions and particulate emission were investigated. The experimental results show that there is a decrease in the brake thermal efficiency when fumigation methanol is applied, except at the highest load of 0.67 MPa. At low loads, the brake thermal efficiency decreases with increase in fumigation methanol; but at high loads, it increases with increase in fumigation methanol. The fumigation method results in a significant increase in hydrocarbon (HC), carbon monoxide (CO), and nitrogen dioxide (NO(2)) emissions. The concentration of nitrogen oxides (NOx) is significantly reduced except at close to full load condition. There is also a reduction in the smoke opacity and the particulate matter (PM) mass concentration. For the submicron particles, the total number of particles decreases at low and medium loads but increases at high loads. In all cases, there is a shift of the particles towards smaller geometrical mean diameter, especially at high loads. The increase in nano-sized particles and the increase in NO(2) emission could have serious impact on human health.

Mortality and kidney histopathology of chinook salmon Oncorhynchus tshawytscha exposed to virulent and attenuated Renibacterium salmoninarum strains

USGS Publications Warehouse

O'Farrell, C. L.; Elliott, D.G.; Landolt, M.L.

2000-01-01

An isolate of Renibacterium salmoninarum (strain MT 239) exhibiting reduced virulence in rainbow trout Oncorhynchus mykiss was tested for its ability to cause bacterial kidney disease (BKD) in chinook salmon Oncorhynchus tshawytscha, a salmonid species more susceptible to BKD. Juvenile chinook salmon were exposed to either 33209, the American Type Culture Collection type strain of R. salmoninarum, or to MT 239, by an intraperitoneal injection of 1 ?? 103 or 1 ?? 106 bacteria fish-1, or by a 24 h immersion in 1 ?? 105 or 1 ?? 107 bacteria ml-1. For 22 wk fish were held in 12??C water and monitored for mortality. Fish were sampled periodically for histological examination of kidney tissues. In contrast to fish exposed to the high dose of strain 33209 by either injection or immersion, none of the fish exposed to strain MT 239 by either route exhibited gross clinical signs or histopathological changes indicative of BKD. However, the MT 239 strain was detected by the direct fluorescent antibody technique in 4 fish that died up to 11 wk after the injection challenge and in 5 fish that died up to 20 wk after the immersion challenge. Viable MT 239 was isolated in culture from 3 fish that died up to 13 wk after the immersion challenge. Total mortality in groups injected with the high dose of strain MT 239 (12%) was also significantly lower (p < 0.05) than mortality in groups injected with strain 33209 (73%). These data indicate that the attenuated virulence observed with MT 239 in rainbow trout also occurs in a salmonid species highly susceptible to BKD. The reasons for the attenuated virulence of MT 239 were not determined but may be related to the reduced levels of the putative virulence protein p57 associated with this strain.

Mortality and kidney histopathology of Chinook salmon Oncorhynchus tshawytscha exposed to virulent and attenuated Renibacterium salmoninarum strains

USGS Publications Warehouse

O'Farrell, Caroline L.; Elliott, Diane G.; Landolt, Marsha L.

2001-01-01

An isolate of Renibacterium salmoninarum (strain MT 239) exhibiting reduced virulence in rainbow trout Oncorhynchus mykiss was tested for its ability to cause bacterial kidney disease (BKD) in chinook salmon Oncorhynchus tshawytscha, a salmonid species more susceptible to BKD. Juvenile chinook salmon were exposed to either 33209, the American Type Culture Collection type strain of R. salmoninarum, or to MT 239, by an intraperitoneal injection of 1 x 10(3) or 1 x 10(6) bacteria fish(-1), or by a 24 h immersion in 1 x 10(5) or 1 x 10(7) bacteria ml(-1). For 22 wk fish were held in 12 degrees C water and monitored for mortality. Fish were sampled periodically for histological examination of kidney tissues. In contrast to fish exposed to the high dose of strain 33209 by either injection or immersion, none of the fish exposed to strain MT 239 by either route exhibited gross clinical signs or histopathological changes indicative of BKD. However, the MT 239 strain was detected by the direct fluorescent antibody technique in 4 fish that died up to 11 wk after the injection challenge and in 5 fish that died up to 20 wk after the immersion challenge. Viable MT 239 was isolated in culture from 3 fish that died up to 13 wk after the immersion challenge. Total mortality in groups injected with the high dose of strain MT 239 (12%) was also significantly lower (p < 0.05) than mortality in groups injected with strain 33209 (73 %). These data indicate that the attenuated virulence observed with MT 239 in rainbow trout also occurs in a salmonid species highly susceptible to BKD. The reasons for the attenuated virulence of MT 239 were not determined but may be related to the reduced levels of the putative virulence protein p57 associated with this strain.

Flame structure of wall-impinging diesel fuel sprays injected by group-hole nozzles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Jian; Moon, Seoksu; Nishida, Keiya

This paper describes an investigation of the flame structure of wall-impinging diesel sprays injected by group-hole nozzles in a constant-volume combustion vessel at experimental conditions typical of a diesel engine. The particular emphasis was on the effect of the included angle between two orifices (0-15 deg. in current study) on the flame structure and combustion characteristics under various simulated engine load conditions. The laser absorption scattering (LAS) technique was applied to analyze the spray and mixture properties. Direct flame imaging and OH chemiluminescence imaging were utilized to quantify the ignition delay, flame geometrical parameters, and OH chemiluminescence intensity. The imagesmore » show that the asymmetric flame structure emerges in wall-impinging group-hole nozzle sprays as larger included angle and higher engine load conditions are applied, which is consistent with the spray shape observed by LAS. Compared to the base nozzle, group-hole nozzles with large included angles yield higher overall OH chemiluminescence intensity, wider flame area, and greater proportion of high OH intensity, implying the better fuel/air mixing and improved combustion characteristics. The advantages of group-hole nozzle are more pronounced under high load conditions. Based on the results, the feasibility of group-hole nozzle for practical direct injection diesel engines is also discussed. It is concluded that the asymmetric flame structure of a group-hole nozzle spray is favorable to reduce soot formation over wide engine loads. However, the hole configuration of the group-hole nozzle should be carefully considered so as to achieve proper air utilization in the combustion chamber. Stoichiometric diesel combustion is another promising application of group-hole nozzle. (author)« less

In Vivo MR Imaging of Pulmonary Perfusion and Gas Exchange in Rats via Continuous Extracorporeal Infusion of Hyperpolarized 129Xe

PubMed Central

Cleveland, Zackary I.; Möller, Harald E.; Hedlund, Laurence W.; Nouls, John C.; Freeman, Matthew S.; Qi, Yi; Driehuys, Bastiaan

2012-01-01

Background Hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) permits high resolution, regional visualization of pulmonary ventilation. Additionally, its reasonably high solubility (>10%) and large chemical shift range (>200 ppm) in tissues allow HP 129Xe to serve as a regional probe of pulmonary perfusion and gas transport, when introduced directly into the vasculature. In earlier work, vascular delivery was accomplished in rats by first dissolving HP 129Xe in a biologically compatible carrier solution, injecting the solution into the vasculature, and then detecting HP 129Xe as it emerged into the alveolar airspaces. Although easily implemented, this approach was constrained by the tolerable injection volume and the duration of the HP 129Xe signal. Methods and Principal Findings Here, we overcome the volume and temporal constraints imposed by injection, by using hydrophobic, microporous, gas-exchange membranes to directly and continuously infuse 129Xe into the arterial blood of live rats with an extracorporeal (EC) circuit. The resulting gas-phase 129Xe signal is sufficient to generate diffusive gas exchange- and pulmonary perfusion-dependent, 3D MR images with a nominal resolution of 2×2×2 mm3. We also show that the 129Xe signal dynamics during EC infusion are well described by an analytical model that incorporates both mass transport into the blood and longitudinal relaxation. Conclusions Extracorporeal infusion of HP 129Xe enables rapid, 3D MR imaging of rat lungs and, when combined with ventilation imaging, will permit spatially resolved studies of the ventilation-perfusion ratio in small animals. Moreover, EC infusion should allow 129Xe to be delivered elsewhere in the body and make possible functional and molecular imaging approaches that are currently not feasible using inhaled HP 129Xe. PMID:22363613

Impurity screening behavior of the high-field side scrape-off layer in near-double-null configurations: prospect for mitigating plasma-material interactions on RF actuators and first-wall components

NASA Astrophysics Data System (ADS)

LaBombard, B.; Kuang, A. Q.; Brunner, D.; Faust, I.; Mumgaard, R.; Reinke, M. L.; Terry, J. L.; Howard, N.; Hughes, J. W.; Chilenski, M.; Lin, Y.; Marmar, E.; Rice, J. E.; Rodriguez-Fernandez, P.; Wallace, G.; Whyte, D. G.; Wolfe, S.; Wukitch, S.

2017-07-01

The impurity screening response of the high-field side (HFS) scrape-off layer (SOL) to localized nitrogen injection is investigated on Alcator C-Mod for magnetic equilibria spanning lower-single-null, double-null and upper-single-null configurations under otherwise identical plasma conditions. L-mode, EDA H-mode and I-mode discharges are investigated. HFS impurity screening is found to depend on magnetic flux balance and the direction of B  ×  \

Research keeps lead and zinc viable in high-tech markets

NASA Astrophysics Data System (ADS)

Cole, Jerome F.

1989-08-01

Lead and zinc have long enjoyed widespread use in a variety of applications. To insure growing markets for the future, however, new applications for these durable metals must be developed. Currently, projects are underway to determine the capabilities of lead for such high-technology uses as earthquake damping and nuclear waste containment. Zinc's capabilities are being developed further, too, particularly in the areas of direct injection die casting, composites and the improvement of coating properties. Other ongoing research initiatives are attempting to better determine the health and environmental influences of these metals.

Feasibility of ultrasound-guided epidural access at the lumbo-sacral space in dogs.

PubMed

Liotta, Annalisa; Busoni, Valeria; Carrozzo, Maria Valentina; Sandersen, Charlotte; Gabriel, Annick; Bolen, Géraldine

2015-01-01

Epidural injections are commonly performed blindly in veterinary medicine. The aims of this study were to describe the lumbosacral ultrasonographic anatomy and to assess the feasibility of an ultrasound-guided epidural injection technique in dogs. A cross sectional anatomic atlas of the lumbosacral region and ex vivo ultrasound images were obtained in two cadavers to describe the ultrasound anatomy and to identify the landmarks. Sixteen normal weight canine cadavers were used to establish two variations of the technique for direct ultrasound-guided injection, using spinal needles or epidural catheters. The technique was finally performed in two normal weight cadavers, in two overweight cadavers and in five live dogs with radiographic abnormalities resulting of the lumbosacral spine. Contrast medium was injected and CT was used to assess the success of the injection. The anatomic landmarks to carry out the procedure were the seventh lumbar vertebra, the iliac wings, and the first sacral vertebra. The target for directing the needle was the trapezoid-shaped echogenic zone between the contiguous articular facets of the lumbosacral vertebral canal visualized in a parasagittal plane. The spinal needle or epidural catheter was inserted in a 45° craniodorsal-caudoventral direction through the subcutaneous tissue and the interarcuate ligament until reaching the epidural space. CT examination confirmed the presence of contrast medium in the epidural space in 25/25 dogs, although a variable contamination of the subarachnoid space was also noted. Findings indicated that this ultrasound-guided epidural injection technique is feasible for normal weight and overweight dogs, with and without radiographic abnormalities of the spine. © 2014 American College of Veterinary Radiology.

In vivo diffusion characteristics following perineural injection of the deep branch of the lateral plantar nerve with mepivacaine or iohexol in horses.

PubMed

Contino, E K; King, M R; Valdés-Martínez, A; McIlwraith, C W

2015-03-01

Hindlimb proximal suspensory desmopathy is a common injury of sport horses but diagnosis can be difficult because diagnostic analgesia of the region lacks specificity. Perineural analgesia of the deep branch of the lateral plantar nerve (DBLPN) has been proposed as a more specific method of isolating pain of the proximal aspect of the suspensory ligament but the technique has not been evaluated in vivo. To determine the extent of diffusion of contrast medium and mepivacaine following DBLPN analgesia using a single-needle injection technique and to determine if there is inadvertent involvement of the tarsal sheath and/or tarsometatarsal (TMT) joint using this technique. In vivo experimental study. Perineural injection of the DBLPN was performed in 16 limbs with 3 ml of either mepivacaine hydrochloride or positive contrast medium. Contrast medium-injected limbs were radiographed 5, 15, and 30 min post injection and diffusion characteristics were described. In mepivacaine-injected limbs, synovial fluid from the TMT joint was obtained 10 and 20 min post injection and mepivacaine concentrations were analysed. At 5, 15 and 30 min post injection, the contrast medium extended, on average, 19.6, 20.6 and 21.0 mm proximal and 38.0, 43.5 and 51.9 mm distal to the injection site, respectively. Three of 8 (37.5%) limbs had evidence of contrast medium in the tarsal sheath. Two of 8 (25%) limbs had mepivacaine concentrations within the TMT joint sufficient to produce analgesia (>300 mg/l) at 10 min post injection. Contrast medium diffused further in a distal direction than in a proximal direction. Analgesia of the DBLPN can result in inadvertent involvement of the tarsal sheath and/or TMT joint. © 2014 EVJ Ltd.

Apparatus and method for preparing oxygen-15 labeled water H{sub 2}[{sup 15}O] in an injectable form for use in positron emission tomography

DOEpatents

Ferrieri, R.A.; Schlyer, D.J.; Alexoff, D.

1996-01-09

A handling and processing apparatus is revealed for preparing Oxygen-15 labeled water (H{sub 2}[{sup 15}O]) in injectable form for use in Positron Emission Tomography from preferably H{sub 2}[{sup 15}O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H{sub 2}[{sup 15}O] gas and impurities, mainly ammonia (NH{sub 3}) gas into sterile water to trap the H{sub 2}[{sup 15}O] and form ammonium (NH{sub 4}{sup +}) in the sterile water. A device for displacing the sterile water containing H{sub 2}[{sup 15}O] and NH{sub 4}{sup +} through a cation resin removes NH{sub 4}{sup +} from the sterile water. A device for combining the sterile water containing H{sub 2}[{sup 15}O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H{sub 2}[{sup 15}O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature. 7 figs.

The effects of solidification on sill propagation dynamics and morphology

NASA Astrophysics Data System (ADS)

Chanceaux, L.; Menand, T.

2016-05-01

Sills are an integral part of the formation and development of larger plutons and magma reservoirs. Thus sills are essential for both the transport and the storage of magma in the Earth's crust. However, although cooling and solidification are central to magmatism, their effects on sills have been so far poorly studied. Here, the effects of solidification on sill propagation dynamics and morphology are studied by means of analogue laboratory experiments. Hot fluid vegetable oil (magma analogue), that solidifies during its propagation, is injected as a sill in a colder layered gelatine solid (elastic host rock analogue). The injection flux and temperature are maintained constant during an experiment and systematically varied between each experiment, in order to vary and quantify the amount of solidification between each experiments. The oil is injected directly at the interface between the two gelatine layers. When solidification effects are small (high injection temperatures and fluxes), the propagation is continuous and the sill has a regular and smooth surface. Inversely, when solidification effects are important (low injection temperatures and fluxes), sill propagation is discontinuous and occurs by steps of surface-area creation interspersed with periods of momentary arrest. The morphology of these sills displays folds, ropy structures on their surface, and lobes with imprints of the leading fronts that correspond to each step of area creation. These experiments show that for a given, constant injected volume, as solidification effects increase, the area of the sills decreases, their thickness increases, and the number of propagation steps increases. These results have various geological and geophysical implications. The morphology of sills, such as lobate structures (interpretation of 3D seismic studies in sedimentary basin) and ropy flow structures (field observations) can be related to solidification during emplacement. Moreover, a non-continuous morphology as observed in the field does not necessarily involve multiple injections, but could instead reflect a continuous, yet complex morphology induced by solidification effects during emplacement. Also, a discontinuous sill propagation induced by solidification effects should be associated with bursts of seismic activity. Finally, our study shows that once a sill has initiated, the dimensionless flux influences the sill thermal state, and in turn its propagation, and final extent and thickness. In restricting the lateral extent of sills, magma cooling and solidification are likely to impact directly the size of plutons constructed by amalgamated sills.

Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body.

PubMed

Schofield, Brett R; Motts, Susan D; Mellott, Jeffrey G; Foster, Nichole L

2014-01-01

Direct projections from the cochlear nucleus (CN) to the medial geniculate body (MG) mediate a high-speed transfer of acoustic information to the auditory thalamus. Anderson etal. (2006) used anterograde tracers to label the projection from the dorsal CN (DCN) to the MG in guinea pigs. We examined this pathway with retrograde tracers. The results confirm a pathway from the DCN, originating primarily from the deep layers. Labeled cells included a few giant cells and a larger number of small cells of unknown type. Many more labeled cells were present in the ventral CN (VCN). These cells, identifiable as multipolar (stellate) or small cells, were found throughout much of the VCN. Most of the labeled cells were located contralateral to the injection site. The CN to MG pathway bypasses the inferior colliculus (IC), where most ascending auditory information is processed. Anderson etal. (2006) hypothesized that CN-MG axons are collaterals of axons that reach the IC. We tested this hypothesis by injecting different fluorescent tracers into the MG and IC and examining the CN for double-labeled cells. After injections on the same side of the brain, double-labeled cells were found in the contralateral VCN and DCN. Most double-labeled cells were in the VCN, where they accounted for up to 37% of the cells labeled by the MG injection. We conclude that projections from the CN to the MG originate from the VCN and, less so, from the DCN. A significant proportion of the cells send a collateral projection to the IC. Presumably, the collateral projections send the same information to both the MG and the IC. The results suggest that T-stellate cells of the VCN are a major source of direct projections to the auditory thalamus.

Effects of octenidine HCl on liver tissue: could it be an alternative scolicidal for Hidatid disease?

PubMed

Arikan, Yüksel; Akbulut, Gökhan; Sahin, Dursun Ali; Dilek, Fatma Hüsniye; Saykol, Volkan; Dilek, Osman Nuri

2007-06-01

Octenidine HCl is new topical antiseptic solution for wounds and abdominal washing that has been found to be highly effective for inactivating scolices in an in vitro study. However, the effects of octenidine HCl on the liver are not yet known. The aim of this study was to determine if there are any histopathologic changes after injecting octenidine HCl into the liver. A group of 50 male Sprague-Dawley rats were included in the study and randomly divided into five groups of 10 rats each, as follows: sham group; 0.09% NaCl group; 20% NaCl group; undiluted octenidine HCl group; 1% octenidine HCl group. The scolicidal agents (0.3 ml) were directly injected into the left lobe of the liver (except in the sham group). At 3 and 7 days after the injection, the rats were sacrificed, and the left lobe of the liver was harvested. Liver tissue was scored for degree of necrosis and the diameter of the necrosis examined under light microscopy. The highest scores were found in the undiluted octenidine HCl group, although a similar effect was observed in the 20% NaCl group. There was no necrosis in the sham group, the 0.09% NaCl group, or the 1% octenidine HCl group. All of the injury was coagulation-type necrosis. No mortality was observed throughout the study. The 1% octenidine HCl solution could thus be used as a scolicidal agent in liver tissue, whereas the undiluted form of octenidine and 20% NaCl solutions were shown to cause necrosis when directly injected into liver tissue in our animal model.

Gene Therapy With Extracellular Superoxide Dismutase Protects Conscious Rabbits Against Myocardial Infarction

PubMed Central

Li, Qianhong; Bolli, Roberto; Qiu, Yumin; Tang, Xian-Liang; Guo, Yiru; French, Brent A.

2013-01-01

Background Extracellular superoxide dismutase (Ec-SOD) may protect the heart against myocardial infarction (MI) because of its extended half-life and capacity to bind heparan sulfate proteoglycans on cellular surfaces. Accordingly, we used direct gene transfer to increase systemic levels of Ec-SOD and determined whether this gene therapy could protect against MI. Methods and Results The cDNA for human Ec-SOD was incorporated into a replication-deficient adenovirus (Ad5/CMV/Ec-SOD). Injection of this virus produced a high level of Ec-SOD in the liver, which was redistributed to the heart and other organs by injection of heparin. Untreated rabbits (group I) underwent a 30-minute coronary occlusion and 3 days of reperfusion. For comparison, preconditioned rabbits (group II) underwent a sequence of six 4-minute-occlusion/4-minute-reperfusion cycles 24 hours before the 30-minute occlusion. Control-treated rabbits (group III) were injected intravenously with Ad5/CMV/nls-LacZ, and gene-therapy rabbits (group IV) were injected with Ad5/CMV/Ec-SOD 3 days before the 30-minute occlusion. Both groups treated with Ad5 received intravenous heparin 2 hours before the 30-minute occlusion. Infarct size (percent risk area) was similar in groups I (57±6%) and III (58±5%). Ec-SOD gene therapy markedly reduced infarct size to 25±4% (P<0.01, group IV versus group III), a protection comparable to that of the late phase of ischemic preconditioning (29±3%, P<0.01 group II versus group I). Conclusions Direct gene transfer of the cDNA encoding membrane-bound Ec-SOD affords powerful cardioprotection, providing proof of principle for the effectiveness of antioxidant gene therapy against MI. PMID:11294809

A bio-inspired microstructure induced by slow injection moulding of cylindrical block copolymers.

PubMed

Stasiak, Joanna; Brubert, Jacob; Serrani, Marta; Nair, Sukumaran; de Gaetano, Francesco; Costantino, Maria Laura; Moggridge, Geoff D

2014-08-28

It is well known that block copolymers with cylindrical morphology show alignment with shear, resulting in anisotropic mechanical properties. Here we show that well-ordered bi-directional orientation can be achieved in such materials by slow injection moulding. This results in a microstructure, and anisotropic mechanical properties, similar to many natural tissues, making this method attractive for engineering prosthetic fibrous tissues. An application of particular interest to us is prosthetic polymeric heart valve leaflets, mimicking the shape, microstructure and hence performance of the native valve. Anisotropic layers have been observed for cylinder-forming block copolymers centrally injected into thin circular discs. The skin layers exhibit orientation parallel to the flow direction, whilst the core layer shows perpendicularly oriented domains; the balance of skin to core layers can be controlled by processing parameters such as temperature and injection rate. Heart valve leaflets with a similar layered structure have been prepared by injection moulding. Numerical modelling demonstrates that such complex orientation can be explained and predicted by the balance of shear and extensional flow.

A technical report on ultrasound-guided scapulocostal syndrome injection.

PubMed

McCarthy, C; Harmon, D

2016-08-01

We describe a case report and technique for using an ultrasound scanner and a linear transducer to guide serratus posterior superior (SPS) muscle injection. A 43-year-old female presented with chronic pain centered under the right upper portion of her scapula impacting her activities of daily living. For the ultrasound-guided SPS muscle injection, the patient was placed in the prone position. The transducer was oriented in a transverse orientation at the level of the C6-T1 vertebrae. Here the SPS muscle attaches to the lower portion of the ligament nuchae and the intervening interspinous ligaments. The muscle fibers run inferiorly and laterally to attach to the 2nd-5th ribs which were identified along with the lateral portion of the serratus posterior superior muscle which is covered by the scapula. Real-time imaging was used to direct a spinal needle into the trigger points of the SPS muscle, where solution was injected under direct vision. The patient's pain symptoms improved significantly. Serratus posterior superior injection can confirm a diagnosis of scapulocostal syndrome and be therapeutically beneficial.

Feasibility of corona discharge ion mobility spectrometry for direct analysis of samples extracted by dispersive liquid-liquid microextraction.

PubMed

Jafari, Mohammad T; Riahi, Farhad

2014-05-23

The capability of corona discharge ionization ion mobility spectrometry (CD-IMS) for direct analysis of the samples extracted by dispersive liquid-liquid microextraction (DLLME) was investigated and evaluated, for the first time. To that end, an appropriate new injection port was designed and constructed, resulting in possibility of direct injection of the known sample volume, without tedious sample preparation steps (e.g. derivatization, solvent evaporation, and re-solving in another solvent…). Malathion as a test compound was extracted from different matrices by a rapid and convenient DLLME method. The positive ion mobility spectra of the extracted malathion were obtained after direct injection of carbon tetrachloride or methanol solutions. The analyte responses were compared and the statistical results revealed the feasibility of direct analysis of the extracted samples in carbon tetrachloride, resulting in a convenient methodology. The coupled method of DLLME-CD-IMS was exhaustively validated in terms of sensitivity, dynamic range, recovery, and enrichment factor. Finally, various real samples of apple, river and underground water were analyzed, all verifying the feasibility and success of the proposed method for the easy extraction of the analyte using DLLME separation before the direct analysis by CD-IMS. Copyright © 2014 Elsevier B.V. All rights reserved.

The 2016 Mw5.1 Fairview, Oklahoma earthquakes: Evidence for long-range poroelastic triggering at >40 km from fluid disposal wells

DOE PAGES

Goebel, T. H. W.; Weingarten, M.; Chen, X.; ...

2017-05-30

Wastewater disposal in the central U.S. is likely responsible for an unprecedented surge in earthquake activity. Much of this activity is thought to be driven by induced pore pressure changes and slip on pre-stressed faults, which requires a hydraulic connection between faults and injection wells. However, direct pressure effects and hydraulic connectivity are questionable for earthquakes located at large distances and depths from the injectors. Here, we examine triggering mechanisms of induced earthquakes, which occurred at more than 40 km from wastewater disposal wells in the greater Fairview region, northwest Oklahoma, employing numerical and semi-analytical poroelastic models. The region exhibitedmore » few earthquakes before 2013, when background seismicity started to accelerate rapidly, culminating in the Mw5.1 Fairview earthquake in February 2016. Injection rates in the ~2–2.5km deep Arbuckle formation started to increase rapidly in 2012, about two years before the start of seismicity-increase. Most of the injection activity was concentrated toward the northeast of the study region, generating a relatively cohesive zone of pressure perturbations between 0.1 and 1MPa. Much of the near-injection seismicity was likely triggered by pressure effects and fault-assisted pressure diffusion to seismogenic depth. Outside of the high-pressure zone, we observed two remarkably detached, linear seismicity clusters, which occurred at 20 to 50 km distance from the initial seismicity and 10 to 40 km from the nearest, high-rate injector. Semi-analytical models reveal that poroelastically-induced Coulomb-stress-changes surpass pore pressure changes at these distances, providing a plausible triggering mechanism in the far-field of injection wells. These results indicate that both pore-pressures and poroelastic stresses can play a significant role in triggering deep and distant earthquakes by fluid injection and should be considered for seismic hazard assessment beyond the targeted reservoir.« less

The 2016 Mw5.1 Fairview, Oklahoma earthquakes: Evidence for long-range poroelastic triggering at >40 km from fluid disposal wells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goebel, T. H. W.; Weingarten, M.; Chen, X.

Wastewater disposal in the central U.S. is likely responsible for an unprecedented surge in earthquake activity. Much of this activity is thought to be driven by induced pore pressure changes and slip on pre-stressed faults, which requires a hydraulic connection between faults and injection wells. However, direct pressure effects and hydraulic connectivity are questionable for earthquakes located at large distances and depths from the injectors. Here, we examine triggering mechanisms of induced earthquakes, which occurred at more than 40 km from wastewater disposal wells in the greater Fairview region, northwest Oklahoma, employing numerical and semi-analytical poroelastic models. The region exhibitedmore » few earthquakes before 2013, when background seismicity started to accelerate rapidly, culminating in the Mw5.1 Fairview earthquake in February 2016. Injection rates in the ~2–2.5km deep Arbuckle formation started to increase rapidly in 2012, about two years before the start of seismicity-increase. Most of the injection activity was concentrated toward the northeast of the study region, generating a relatively cohesive zone of pressure perturbations between 0.1 and 1MPa. Much of the near-injection seismicity was likely triggered by pressure effects and fault-assisted pressure diffusion to seismogenic depth. Outside of the high-pressure zone, we observed two remarkably detached, linear seismicity clusters, which occurred at 20 to 50 km distance from the initial seismicity and 10 to 40 km from the nearest, high-rate injector. Semi-analytical models reveal that poroelastically-induced Coulomb-stress-changes surpass pore pressure changes at these distances, providing a plausible triggering mechanism in the far-field of injection wells. These results indicate that both pore-pressures and poroelastic stresses can play a significant role in triggering deep and distant earthquakes by fluid injection and should be considered for seismic hazard assessment beyond the targeted reservoir.« less

The 2016 Mw5.1 Fairview, Oklahoma earthquakes: Evidence for long-range poroelastic triggering at >40 km from fluid disposal wells

NASA Astrophysics Data System (ADS)

Goebel, T. H. W.; Weingarten, M.; Chen, X.; Haffener, J.; Brodsky, E. E.

2017-08-01

Wastewater disposal in the central U.S. is likely responsible for an unprecedented surge in earthquake activity. Much of this activity is thought to be driven by induced pore pressure changes and slip on pre-stressed faults, which requires a hydraulic connection between faults and injection wells. However, direct pressure effects and hydraulic connectivity are questionable for earthquakes located at large distances and depths from the injectors. Here, we examine triggering mechanisms of induced earthquakes, which occurred at more than 40 km from wastewater disposal wells in the greater Fairview region, northwest Oklahoma, employing numerical and semi-analytical poroelastic models. The region exhibited few earthquakes before 2013, when background seismicity started to accelerate rapidly, culminating in the Mw5.1 Fairview earthquake in February 2016. Injection rates in the ∼2-2.5 km deep Arbuckle formation started to increase rapidly in 2012, about two years before the start of seismicity-increase. Most of the injection activity was concentrated toward the northeast of the study region, generating a relatively cohesive zone of pressure perturbations between 0.1 and 1 MPa. Much of the near-injection seismicity was likely triggered by pressure effects and fault-assisted pressure diffusion to seismogenic depth. Outside of the high-pressure zone, we observed two remarkably detached, linear seismicity clusters, which occurred at 20 to 50 km distance from the initial seismicity and 10 to 40 km from the nearest, high-rate injector. Semi-analytical models reveal that poroelastically-induced Coulomb-stress-changes surpass pore pressure changes at these distances, providing a plausible triggering mechanism in the far-field of injection wells. These results indicate that both pore-pressures and poroelastic stresses can play a significant role in triggering deep and distant earthquakes by fluid injection and should be considered for seismic hazard assessment beyond the targeted reservoir.

Time-lapse integrated geophysical imaging of magmatic injections and fluid-induced fracturing causing Campi Flegrei 1983-84 Unrest

NASA Astrophysics Data System (ADS)

De Siena, Luca; Crescentini, Luca; Amoruso, Antonella; Del Pezzo, Edoardo; Castellano, Mario

2016-04-01

Geophysical precursors measured during Unrest episodes are a primary source of geophysical information to forecast eruptions at the largest and most potentially destructive volcanic calderas. Despite their importance and uniqueness, these precursors are also considered difficult to interpret and unrepresentative of larger eruptive events. Here, we show how novel geophysical imaging and monitoring techniques are instead able to represent the dynamic evolution of magmatic- and fluid-induced fracturing during the largest period of Unrest at Campi Flegrei caldera, Italy (1983-1984). The time-dependent patterns drawn by microseismic locations and deformation, once integrated by 3D attenuation tomography and absorption/scattering mapping, model injections of magma- and fluid-related materials in the form of spatially punctual microseismic bursts at a depth of 3.5 km, west and offshore the city of Pozzuoli. The shallowest four kilometres of the crust work as a deformation-based dipolar system before and after each microseismic shock. Seismicity and deformation contemporaneously focus on the point of injection; patterns then progressively crack the medium directed towards the second focus, a region at depths 1-1.5 km south of Solfatara. A single high-absorption and high-scattering aseismic anomaly marks zones of fluid storage overlying the first dipolar centre. These results provide the first direct geophysical signature of the processes of aseismic fluid release at the top of the basaltic basement, producing pozzolanic activity and recently observed via rock-physics and well-rock experiments. The microseismicity caused by fluids and gasses rises to surface via high-absorption north-east rising paths connecting the two dipolar centres, finally beingq being generally expelled from the maar diatreme Solfatara structure. Geophysical precursors during Unrest depict how volcanic stress was released at the Campi Flegrei caldera during its period of highest recorded seismicity and deformation; they may work as a template for modelling future events in the case the volcano was approaching eruption conditions.

Direct determination of energy level alignment and charge transport at metal-Alq3 interfaces via ballistic-electron-emission spectroscopy.

PubMed

Jiang, J S; Pearson, J E; Bader, S D

2011-04-15

Using ballistic-electron-emission spectroscopy (BEES), we directly determined the energy barrier for electron injection at clean interfaces of Alq(3) with Al and Fe to be 2.1 and 2.2 eV, respectively. We quantitatively modeled the sub-barrier BEES spectra with an accumulated space charge layer, and found that the transport of nonballistic electrons is consistent with random hopping over the injection barrier.

Direct determination of energy level alignment and charge transport at metal/Alq{sub 3} interfaces via ballistic-electron-emission spectroscopy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, J. S.; Pearson, J. E.; Bader, S. D.

2011-04-15

Using ballistic-electron-emission spectroscopy (BEES), we directly determined the energy barrier for electron injection at clean interfaces of Alq{sub 3} with Al and Fe to be 2.1 and 2.2 eV, respectively. We quantitatively modeled the sub-barrier BEES spectra with an accumulated space charge layer, and found that the transport of nonballistic electrons is consistent with random hopping over the injection barrier.

Injection molding as a one-step process for the direct production of pharmaceutical dosage forms from primary powders.

PubMed

Eggenreich, K; Windhab, S; Schrank, S; Treffer, D; Juster, H; Steinbichler, G; Laske, S; Koscher, G; Roblegg, E; Khinast, J G

2016-05-30

The objective of the present study was to develop a one-step process for the production of tablets directly from primary powder by means of injection molding (IM), to create solid-dispersion based tablets. Fenofibrate was used as the model API, a polyvinyl caprolactame-polyvinyl acetate-polyethylene glycol graft co-polymer served as a matrix system. Formulations were injection-molded into tablets using state-of-the-art IM equipment. The resulting tablets were physico-chemically characterized and the drug release kinetics and mechanism were determined. Comparison tablets were produced, either directly from powder or from pre-processed pellets prepared via hot melt extrusion (HME). The content of the model drug in the formulations was 10% (w/w), 20% (w/w) and 30% (w/w), respectively. After 120min, both powder-based and pellet-based injection-molded tablets exhibited a drug release of 60% independent of the processing route. Content uniformity analysis demonstrated that the model drug was homogeneously distributed. Moreover, analysis of single dose uniformity also revealed geometric drug homogeneity between tablets of one shot. Copyright © 2016 Elsevier B.V. All rights reserved.

A Quasi-Periodic Linear Feeder for the Impurity Granular Injection on DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagy, Alex; Bortolon, A.; Brown, W.

Injection of solid nonfuel pellets has been actively used as a tool for pacing and mitigation of edge localized modes (ELMs). In DIII-D, effective ELM pacing has been demonstrated by the high-frequency injection of lithium and carbon submillimeter spheres, using the impurity granule injector (IGI). This device injects granules into the plasma at speeds up to 150 m/s, through impact with a rotating impeller. In the IGI, high-frequency granule delivery was accomplished through a vibrational granule dropper, in which high time-average rates are obtained at the cost of lack of period control. Here, we present a new in-line granule feeder,more » capable of delivering granules of size 0.2-2 mm with no restriction of material properties, at quasi-periodic rates of up to 150 Hz, for 0.7-mm diameter lithium granules (600 Hz using 0.3-mm granules). The new dropper mechanism combines two piezo-in-line units; one which feeds the impeller and one which circulates granules that are filtered out of the feeder path. A remotely adjustable filter eliminates granules that are stacked, oversized, or side by side allowing the formation of a single moving granule injection line. The granules fall off the in-line feeder exit one at a time, achieving a quasi-periodic delivery rate proportional to the exit speed. At higher rates, the periodicity deteriorates. This behavior was studied using high-speed cameras and electrostatic measurements, and it was found that at drop rates <60 Hz, the granule delivery period has a variation of ±25% which appears to be caused by gaps which develop in the last centimeter of the injection line, as granules exit off the moving track. The linear feeder concept is robust against bridge instabilities and clogging issues, thanks to the simple diverter filter and constant recirculation of granules. Furthermore, the open-top design of the device facilitates refilling the device from separate reservoirs and has easy access for directly monitoring operation and adjustment. This paper describes the details of the in-line feeder design, along with several design iterations. The goal is a robust in-vacuum mechanism that can deliver granule flow ranging from a single particle to a line of particles at 150 per second, using different sizes and materials from the same apparatus.« less

A Quasi-Periodic Linear Feeder for the Impurity Granular Injection on DIII-D

DOE PAGES

Nagy, Alex; Bortolon, A.; Brown, W.; ...

2018-04-10

Injection of solid nonfuel pellets has been actively used as a tool for pacing and mitigation of edge localized modes (ELMs). In DIII-D, effective ELM pacing has been demonstrated by the high-frequency injection of lithium and carbon submillimeter spheres, using the impurity granule injector (IGI). This device injects granules into the plasma at speeds up to 150 m/s, through impact with a rotating impeller. In the IGI, high-frequency granule delivery was accomplished through a vibrational granule dropper, in which high time-average rates are obtained at the cost of lack of period control. Here, we present a new in-line granule feeder,more » capable of delivering granules of size 0.2-2 mm with no restriction of material properties, at quasi-periodic rates of up to 150 Hz, for 0.7-mm diameter lithium granules (600 Hz using 0.3-mm granules). The new dropper mechanism combines two piezo-in-line units; one which feeds the impeller and one which circulates granules that are filtered out of the feeder path. A remotely adjustable filter eliminates granules that are stacked, oversized, or side by side allowing the formation of a single moving granule injection line. The granules fall off the in-line feeder exit one at a time, achieving a quasi-periodic delivery rate proportional to the exit speed. At higher rates, the periodicity deteriorates. This behavior was studied using high-speed cameras and electrostatic measurements, and it was found that at drop rates <60 Hz, the granule delivery period has a variation of ±25% which appears to be caused by gaps which develop in the last centimeter of the injection line, as granules exit off the moving track. The linear feeder concept is robust against bridge instabilities and clogging issues, thanks to the simple diverter filter and constant recirculation of granules. Furthermore, the open-top design of the device facilitates refilling the device from separate reservoirs and has easy access for directly monitoring operation and adjustment. This paper describes the details of the in-line feeder design, along with several design iterations. The goal is a robust in-vacuum mechanism that can deliver granule flow ranging from a single particle to a line of particles at 150 per second, using different sizes and materials from the same apparatus.« less

Heat transfer characteristics of a surface type direct contact boiler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deeds, R.S.; Jacobs, H.R.; Boehm, R.F.

1976-03-01

Two direct contact heat exchangers were constructed and test results were obtained using water and refrigerant 113 as the working fluids. The heat exchangers were operated in a three-phase mode; the water remained liquid throughout the vessel and the liquid refrigerant 113 underwent vaporization following direct injection into the water. The effect of important operational parameters--operating heights, refrigerant 113 injection techniques, mass flow ratios, and temperatures--was studied to determine generalized trends important in the design and operation of a prototype three-phase direct contact heat exchanger. The primary system used in this study performed well overall. The initial favorable results ofmore » this study warrant further investigation of direct contact heat exchange as a means of utilizing geothermal energy.« less