Science.gov

Sample records for dirk van elsas

  1. Dirk Forrister -- Looking at U.S. climate change policy

    SciTech Connect

    1997-11-01

    This month, American Gas presents another in its series of interviews with influential policy-makers in Washington. This interview with Dirk Forrister, chairman of the White House Climate Change Task Force, focuses on the upcoming United Nations conference on global warming, being held December 1--10 in Kyoto, Japan, and on the Clinton administration`s position and policies on global climate change.

  2. Polarized electrons in ELSA (preliminary results)

    NASA Astrophysics Data System (ADS)

    Nakamura, S.; von Drachenfels, W.; Durek, D.; Frommberger, F.; Hoffmann, M.; Husmann, D.; Kiel, B.; Klein, F. J.; Menze, D.; Michel, T.; Nakanishi, T.; Naumann, J.; Reichelt, T.; Steier, C.; Toyama, T.; Voigt, S.; Westermann, M.

    1998-01-01

    Polarized electrons have been accelerated in the electron stretcher accelerator ELSA for the first time. Up to 2.1 GeV the polarization of the electron beam supplied by the 120 keV polarized electron source has been measured with a Mo/ller polarimeter. Preliminary results of polarization measurements at high energies and the performance of the source are presented.

  3. Official portrait of STS-45 Payload Specialist Dirk D. Frimout of Belgium

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Official portrait of STS-45 Payload Specialist Dirk D. Frimout of Belgium. Frimout, wearing launch and entry suit (LES), holds LES gloves and has his left arm on launch and entry helmet (LEH). Displayed in the background are the United States flag and a space shuttle model.

  4. The Bgo-Od Experiment at Elsa

    NASA Astrophysics Data System (ADS)

    Bantes, B.; Bayadilov, D.; Beck, R.; Becker, M.; Bella, A.; Bieling, J.; Böse, S.; Braglieri, A.; Brinkmann, K.; Burdeynyi, D.; Curciarello, F.; de Leo, V.; di Salvo, R.; Dutz, H.; Elsner, D.; Fantini, A.; Frese, T.; Friedrick, S.; Frommberger, F.; Ganenko, V.; Gervino, G.; Ghio, F.; Giardina, G.; Girolami, B.; Glazier, D.; Goertz, S.; Gridnev, A.; Gutz, E.; Hammann, D.; Hannappel, J.; Hillert, W.; Ignatov, A.; Jahn, O.; Jahn, R.; Joosten, R.; Jude, T. C.; Klein, F.; Koop, K.; Krusche, B.; Lapik, A.; Levi Sandri, P.; Lopatin, I.; Mandaglio, G.; Messi, F.; Messi, R.; Metag, V.; Moricciani, D.; Nanova, M.; Nedorezov, V.; Noviskiy, D.; Pedroni, P.; Romaniuk, M.; Rostomyan, T.; Schaerf, C.; Schmieden, H.; Sumachev, V.; Tarakonov, V.; Vegna, V.; Vlasov, P.; Walther, D.; Watts, D.; Zaunick, H.-G.; Zimmermann, T.

    2014-01-01

    Meson photoproduction is a key tool for the experimental investigation of the nucleon excitation spectrum. To disentangle the specific couplings of resonances, in addition to the rather well measured pion and eta photoproduction channels it is mandatory to obtain information on channels involving strange and vector mesons and higher mass pseudoscalar mesons, and the associated multi-particle final states with both charged and neutral particles. In this respect, the new BGO-OD experiment at the ELSA accelerator of the University of Bonn's Physikalisches Institut provides unique instrumentation. We describe the experiment, present its status and the initial program of measurements.

  5. The Bgo-Opendipole Setup at Elsa

    NASA Astrophysics Data System (ADS)

    Schmieden, Hartmut

    At the electron accelerator facility ELSA of the University of Bonn presently the new BGO-OpenDipole experiment is being setup. It is optimized for meson photoproduction final states of mixed charges. The detector combines hermetic coverage for photon detection through the BGO ball of the former GRAAL experiment with high resolution detection of forward going charged particles in the Open Dipole spectrometer. This setup is well suited for many different channels, including pseudoscalar, vectormeson and associated strangeness photoproduction. This contribution highlights the strangeness channels associated with the Λ and Σ ground states and the Λ(1405) excited state.

  6. The polarized electron beam at ELSA

    NASA Astrophysics Data System (ADS)

    Hoffmann, M.; Drachenfels, W. V.; Frommberger, F.; Gowin, M.; Helbing, K.; Hillert, W.; Husmann, D.; Keil, J.; Michel, T.; Naumann, J.; Speckner, T.; Zeitler, G.

    2001-06-01

    The future medium energy physics program at the electron stretcher accelerator ELSA of Bonn University mainly relies on experiments using polarized electrons in the energy range from 1 to 3.2 GeV. To provide a polarized beam with high polarization and sufficient intensity a dedicated source has been developed and set into operation. To prevent depolarization during acceleration in the circular accelerators several depolarizing resonances have to be corrected for. Intrinsic resonances are compensated using two pulsed betatron tune jump quadrupoles. The influence of imperfection resonances is successfully reduced applying a dynamic closed orbit correction in combination with an empirical harmonic correction on the energy ramp. In order to minimize beam depolarization, both types of resonances and the correction techniques have been studied in detail. It turned out that the polarization in ELSA can be conserved up to 2.5 GeV and partially up to 3.2 GeV which is demonstrated by measurements using a Møller polarimeter installed in the external GDH1-beamline. .

  7. [Medical assessments and measurements in ELSA-Brasil].

    PubMed

    Mill, Jose Geraldo; Pinto, Karina; Griep, Rosane Härter; Goulart, Alessandra; Foppa, Murilo; Lotufo, Paulo A; Maestri, Marcelo K; Ribeiro, Antonio Luiz; Andreão, Rodrigo Varejão; Dantas, Eduardo Miranda; Oliveira, Ilka; Fuchs, Sandra C; Cunha, Roberto de Sá; Bensenor, Isabela M

    2013-06-01

    The article describes assessments and measurements performed in the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil). Some assessments including anthropometric assessment, casual blood pressure measurement, and ankle-brachial index have an established clinical application while others including pulse wave velocity, heart rate variability, and carotid intima-media thickness have no established application and do not have reference values for healthy Brazilian population but may be important predictors of cardiovascular outcomes. Blood pressure measurement following postural change maneuver was included in the ELSA-Brasil because it has not been much tested in epidemiological studies. Innovative approaches were developed for assessing the ankle-brachial index using an automatic device instead of the mercury column to measure blood pressure and for assessing the anterior-posterior diameter of the right lobe of the liver by ultrasound for quantitative assessment of nonalcoholic fatty liver disease. All ELSA-Brasil subjects were younger (35 years or more) than those included in other cohorts studying subclinical atherosclerosis. The inclusion of younger individuals and a variety of assessments make the ELSA-Brasil a relevant epidemiology study nationwide and worldwide.

  8. [ELSA-Brasil strategies for outcome identification, investigation and ascertainment].

    PubMed

    Barreto, Sandhi Maria; Ladeira, Roberto Marini; Bastos, Maria do Socorro Castelo Branco de Oliveira; Diniz, Maria de Fátima Haueisen Sander; Jesus, Elcimara Amorim de; Kelles, Silvana Márcia Bruschi; Luft, Vivian Cristine; Melo, Enirtes Caetano Prates; Oliveira, Elizabete Regina Araújo de

    2013-06-01

    The article describes the strategies adopted by the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) for participation and retention of subjects. This is key to ensure internal validity of longitudinal studies, and to identify, investigate, and ascertain outcomes of interest. The follow-up strategies include annual telephone contacts with new assessments and interviews every three to four years this approach aims to identify transient outcomes (reversible or not), permanent outcomes as well as complications related to the progression of major diseases--cardiovascular diseases and diabetes--to be studied. Telephone interviews are designed to monitor subjects' health status and to identify potential health-related events such as hospital admissions, medical visits or pre-selected medical procedures. Subjects are also encouraged to report to the ELSA-Brasil team any new health-related events. When a potential event is identified, a thorough investigation is carried out to collect relevant information about that event from medical records. All data are blinded and reviewed and analyzed by a medical expert committee. Incident outcome ascertainment follows well-established international criteria to ensure data comparability and avoid misclassification. In addition to these strategies, the occurrence of health-related events is also investigated through linkage of secondary databases, such as national mortality and hospital admission databases. Accurate identification of outcomes will allow to estimating their incidence in the study cohort and to investigate the effect of the exposures studied in the ELSA-Brasil at baseline and at its subsequent waves.

  9. Longitudinal phase space experiments on the ELSA photoinjector

    SciTech Connect

    Dowell, D.H.; Joly, S.; Brion, J.P. de

    1995-12-31

    The excellent beam quality produced by RF photocathode injectors is well established, andhas been verified by numerous measurements of the transverse emittance. However, there are few experimental determinations of the longitudinal phase space. This paper reports on experiments performed at the ELSA FEL facility to emasure the longitudinal phase space distribution at the exit of the 144 MHz photoinjector cavity. Phase spaces were determined by the analysis of beam energy spectra and pulse shapes at 17.5 MeV for micropulse charges between 0.5 and 5 nC.

  10. Where is ELSA? The early to late shift in aging.

    PubMed

    Dew, Ilana T Z; Buchler, Norbou; Dobbins, Ian G; Cabeza, Roberto

    2012-11-01

    Studies of cognitive and neural aging have recently provided evidence of a shift from an early- to late-onset cognitive control strategy, linked with temporally extended activity in the prefrontal cortex (PFC). It has been uncertain, however, whether this age-related shift is unique to PFC and executive control tasks or whether the functional location might vary depending on the particular cognitive processes that are altered. The present study tested whether an early-to-late shift in aging (ELSA) might emerge in the medial temporal lobes (MTL) during a protracted context memory task comprising both anticipatory cue (retrieval preparation) and retrieval probe (retrieval completion) phases. First, we found reduced MTL activity in older adults during the early retrieval preparation phase coupled with increased MTL activity during the late retrieval completion phase. Second, we found that functional connectivity between MTL and PFC regions was higher during retrieval preparation in young adults but higher during retrieval completion in older adults, suggesting an important interactive relationship between the ELSA pattern in MTL and PFC. Taken together, these results critically suggest that aging results in temporally lagged activity even in regions not typically associated with cognitive control, such as the MTL.

  11. Archiving Derived Data with the PDS Atmospheres Node: The Educational Labeling System for Atmospheres (ELSA)

    NASA Astrophysics Data System (ADS)

    Neakrase, L. D. V.; Hornung, D.; Chanover, N.; Huber, L.; Beebe, R.; Johnson, J.; Sweebe, K.; Stevenson, Z.

    2017-06-01

    The PDS Atmospheres Node is developing an online tool, the Educational Labeling System for Atmospheres (ELSA), to aid in planning and creation of PDS4 bundles and associated labels for archiving derived data.

  12. Physical activity in Brazil: lessons from ELSA-Brasil. Narrative review.

    PubMed

    Pitanga, Francisco José Gondim; Almeida, Maria Conceição Chagas; Queiroz, Ciro Oliveira; Aquino, Estela Maria Leão de; Matos, Sheila Maria Alvim

    2017-01-01

    The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) was conducted among civil servants at six higher education institutions located in six Brazilian state capitals. The objective of this review was to identify the publications produced within the scope of ELSA-Brasil that analyzed the participants' physical activity. Review study using baseline data from ELSA-Brasil. Narrative review of Brazilian studies on physical activity produced using data from ELSA-Brasil participants. The prevalence of leisure-time physical activity (LTPA) among ELSA-Brasil participants was low (44.1% among men and 33.8% among women). The main factors associated were social (higher schooling and family income), environmental (living in places with conditions and opportunities for physical activity) and individual (not being obese, being retired, not smoking and positive perception of body image). The perception of facilities for walking in the neighborhood was positively associated with both LTPA and commuting-related physical activity. An active lifestyle was a protective factor against several cardiometa-bolic variables (hypertension, diabetes, lipid abnormalities and cardiovascular risk over the next 10 years). Comparison between LTPA and commuting-related physical activity showed that only LTPA had a protective effect against arterial hypertension. The prevalence of physical activity among ELSA-Brasil participants was low. The main determinants were social, environmental and personal. LTPA had a greater protective efect on cardio-metabolic outcomes than did commuting-related physical activity.

  13. ELSa interventional Portuguese health program to promote physical activity.

    PubMed

    Mourão Carvalhal, Maria Isabel Martins; Fonseca, Sandra; de Castro Coelho, Eduarda Maria Rocha Teles

    2011-10-01

    The aim of the communication was to present the baseline data from incidence of obesity, eating habits, physical activity and sedentary behaviour, before ELSa, interventional Portuguese health program. The sample was composed of 496 children (238 girls and 258 boys) with an average 7.7 (± 2.5) years of age. Thinness, overweight and obesity were calculated by using the BMI and the cut off of Cole et al., 24 h dietary recalls and a general questionnaire was completed by the parents to provide information about eating habits, sedentary behaviour and physical activity. The results indicated high incidence of overweight and obesity, many hours in screen activities and low level of physical activity. The eating habits seemed healthy, but our children's lifestyles were sedentary. To combat the high incidence of obesity it is very urgent to design a multi-level intervention aimed to modify key behaviours: physical activity, screen time and nutrition.

  14. The eruption history of the quaternary Eifel volcanic fields: Implications from the ELSA - Tephra - Stack

    NASA Astrophysics Data System (ADS)

    Förster, Michael; Sirocko, Frank

    2015-04-01

    Numerous tephra layers occur in maar sediments in the quaternary Eifel volcanic fields. The sediments were systematically drilled and cored since 1998 by the Eifel Laminated Sediment Archive project (ELSA) (Sirocko et al. 2013). These maar sediments are laminated and the tephra is easily recognizeable by a coarser grain size. Additionaly, tephra layers appear dark grey to black in color. The ashes were sieved to a fraction of 250 - 100 µm and sorted into grains of: reddish and greyish sandstone, quartz, amphibole, pyroxene, scoria and pumice, sanidine, leucite and biotite. A minimum of 100 grains for each tephra layer were used for a sediment petrographic tephra characterisation (SPTC). The grain counts resemble the vol. -% of each grain species. Three types of tephra could be identified by their distinctive grain pattern: (1) phreatomagmatic tephra, rich in basement rocks like greyish/reddish sandstone and quartz. (2) Strombolian tephra, rich in scoria and mafic minerals like pyroxene. (3) evolved tephra, rich in sanidine and pumice. 16 drill-cores, covering the last 500 000 years have been examined. Younger cores were dated by 14C ages and older cores by optical stimulated luminescence. Independently from this datings, the drill-cores were cross-correlated by pollen and the occurences of specific marker-tephra layers, comprising characteristic grain-types. These marker-tephra layers are especially thick and of evolved composition with a significant abundance of sanidine and pumice. The most prominent tephra layers of this type are the Laacher See tephra, dated to 12 900 b2k by Zolitschka (1998), the 40Ar/39Ar dated tephra layers of Dümpelmaar, Glees and Hüttenberg, dated to 116 000 b2k, 151 000 b2k and 215 000 b2k by van den Bogaard & Schmincke (1990), van den Bogaard et al. (1989). These datings set the time-frame for the eruption-phases of the quaternary Eifel Volcanic Fields. Our study refines these findings and shows that phases of activity are very

  15. [Design and implementation of the ELSA-Brasil biobank: a prospective study in a Brazilian population].

    PubMed

    Pereira, Alexandre C; Bensenor, Isabela M; Fedeli, Ligia M; Castilhos, Cristina; Vidigal, Pedro G; Maniero, Viviane; Leite, Claudia M; Pimentel, Robercia A; Duncan, Bruce B; Mill, Jose Geraldo; Lotufo, Paulo A

    2013-06-01

    The Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) is a multicenter prospective cohort of civil servants designed to assess the determinants of chronic diseases, especially cardiovascular diseases and type 2 diabetes. The present article describes the main design and implementation points of the ELSA-Brasil biobank project. Economic, political, logistical and technological aspects of this study are characterized. Additionally, it discusses the final biorepository protocol and the facilities implemented to achieve this objective. The design and implementation process of the ELSA-Brasil biobank took three years to be performed. Both the central and local biobanks were built according to the best biorepository techniques, using different technological solutions for the distinct needs expected in this study.

  16. Cohort Profile: Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    Schmidt, Maria Inês; Duncan, Bruce B; Mill, José Geraldo; Lotufo, Paulo A; Chor, Dóra; Barreto, Sandhi Maria; Aquino, Estela ML; Passos, Valéria Maria Azeredo; Matos, Sheila MA; Molina, Maria del Carmen B; Carvalho, Marilia S; Bensenor, Isabela M

    2015-01-01

    Chronic diseases are a global problem, yet information on their determinants is generally scant in low- and middle-income countries. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information regarding the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes, in one such setting. At Visit 1, we enrolled 15 105 civil servants from predefined universities or research institutes. Baseline assessment (2008–10) included detailed interviews and measurements to assess social and biological determinants of health, as well as various clinical and subclinical conditions related to diabetes, cardiovascular diseases and mental health. A second visit of interviews and examinations is under way (2012–14) to enrich the assessment of cohort exposures and to detect initial incident events. Annual surveillance has been conducted since 2009 for the ascertainment of incident events. Biological samples (sera, plasma, urine and DNA) obtained at both visits have been placed in long-term storage. Baseline data are available for analyses, and collaboration via specific research proposals directed to study investigators is welcome. PMID:24585730

  17. The GDH-M øller-Polarimeter at ELSA

    NASA Astrophysics Data System (ADS)

    Speckner, T.; Anton, G.; von Drachenfels, W.; Frommberger, F.; Helbing, K.; Hoffmann, M.; Kiel, B.; Michel, T.; Naumann, J.; Zeitler, G.

    2004-03-01

    The design, setup and performance of a new two-arm coincidence, large acceptance and variable energy M øller-Polarimeter used within the GDH-Experiment at the Electron Stretcher Accelerator Facility (ELSA) in Bonn is described. The polarimeter employs a dipole magnetic spectrometer and lead glass detectors to detect both M øller scattered electrons in coincidence. A target system consisting of three different pairs of coils provides the magnetic field to magnetize Vacoflux foils in three different space orientations. This allows to measure all beam polarization components. The variable geometry of the detector system enables adjustments to the kinematic conditions between 0.8 and 3.5 GeV electron beam energy. A large center of mass acceptance of θ¯=[65°;115°] provides the measurement of the longitudinal electron beam polarization, for example at 1.9 GeV with a statistical precision of 1% within 10 min ( I e≈500 pA). Unprecedented systematic studies of M øller polarimetry as well as direct measurements of the transversal beam polarization components have been performed with this device.

  18. Work-family conflict and time use: psychometric assessment of an instrument in ELSA-Brazil

    PubMed Central

    Pinto, Karina Araujo; Menezes, Greice Maria de Souza; Griep, Rosane Härter; Lima, Keury Thaisana Rodrigues dos Santos; Almeida, Maria da Conceição; Aquino, Estela M L

    2016-01-01

    ABSTRACT In this study, we evaluated the psychometric properties of the items to measure the work-family conflict and the time use for personal care and leisure, included in the baseline questionnaire of the Longitudinal Study of Adult Health (ELSA-Brazil). We evaluated temporal stability (7-14 days) using kappa statistic and the validity of the construct by the correlation of Kendall’s tau with other variables. Test-retest stability was discreet to moderate and the correlations were compatible with the underlying theory. Future studies in the context of ELSA-Brazil and in other populations will complement the assessment of its relevance. PMID:27384968

  19. [Clinical evaluation of Engström's electrically controlled ELSA for low flow closed circuit anesthesia].

    PubMed

    Igarashi, M; Nakae, Y; Ichimiya, N; Watanabe, H; Iwasaki, H; Namiki, A

    1993-02-01

    Many anesthesiologists are now interested in low flow, closed circuit anesthesia from an economical and environmental point of view. In order to evaluate clinically a newly developed electronically controlled anesthesia machine Engström's ELSA, we compared low flow, closed circuit anesthesia on 38 ASA I-II patients using ELSA, with high flow anesthesia on 12 ASA I-II patients using a conventional anesthesia machine. The results were as follows; 1. We could perform safe and economical low flow, closed circuit anesthesia using ELSA's injection vaporizer and accurate monitoring devices for O2, N2O, CO2 and concentrations of various volatile anesthetic agents. 2. Under low flow anesthesia, isoflurane consumption was 5.3 +/- 1.1 ml.h-1 x Vol.%-1 (mean +/- SE) with ELSA, which is about one fourth of the high flow anesthesia consumption (22.6 +/- 2.1 ml.h-1 x Vol.%-1 (mean +/- SE). 3. Low flow closed circuit anesthesia could maintain significantly higher temperature and humidity compared with high flow anesthesia. 4. Under low flow anesthesia of more than 7hrs, color of soda lime becomes blue, but this does not affect FIO2 nor PaCO2, and the method is clinically safe for patients.

  20. Migraine and subclinical atherosclerosis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Goulart, Alessandra C; Santos, Itamar S; Bittencourt, Márcio S; Lotufo, Paulo A; Benseñor, Isabela M

    2016-08-01

    The relationship between migraine and coronary heart disease (CHD) remains controversial. We aimed to investigate the association of subclinical atherosclerosis and migraine with or without aura compared to a non-migraine subgroup (reference) in a large Brazilian multicentric cohort study, the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Migraine diagnostic was based on International Headache Society criteria, and aura symptoms were validated by a medical doctor in a sub-sample of the ELSA-Brasil, who also underwent coronary artery calcium score (CAC) and carotid intima-media thickness (C-IMT) evaluations. Subclinical atherosclerosis indexes (CAC and C-IMT) were analyzed as dependent variables and migraine (all, with aura, without aura) as an independent variable in the linear and multinomial logistic regression models adjusted for possible confounders. Of 3217 ELSA participants free from CVD at baseline, we found a migraine frequency of 11.9% (5.1% with aura and 6.8% without aura). Overall, migraineurs were mostly women, younger and had lower frequency of CV risk factors, such as hypertension, diabetes and low HDL-cholesterol, compared to non-migraineurs. The strongest inverse correlation between migraine and subclinical atherosclerosis was verified with CAC score. However, all associations lost their significance after multivariate adjustment. In this cross-sectional evaluation of the ELSA study, migraine was not associated with subclinical atherosclerosis, regardless of aura symptoms. © International Headache Society 2015.

  1. Work-family conflict and time use: psychometric assessment of an instrument in ELSA-Brazil.

    PubMed

    Pinto, Karina Araujo; Menezes, Greice Maria de Souza; Griep, Rosane Härter; Lima, Keury Thaisana Rodrigues Dos Santos; Almeida, Maria da Conceição; Aquino, Estela M L

    2016-07-04

    In this study, we evaluated the psychometric properties of the items to measure the work-family conflict and the time use for personal care and leisure, included in the baseline questionnaire of the Longitudinal Study of Adult Health (ELSA-Brazil). We evaluated temporal stability (7-14 days) using kappa statistic and the validity of the construct by the correlation of Kendall's tau with other variables. Test-retest stability was discreet to moderate and the correlations were compatible with the underlying theory. Future studies in the context of ELSA-Brazil and in other populations will complement the assessment of its relevance. RESUMO Neste estudo, avaliamos as propriedades psicométricas dos itens para mensurar o conflito trabalho-família e o uso do tempo para cuidado pessoal e lazer, incluídos no questionário da linha de base do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Foram avaliadas a estabilidade temporal (7-14 dias) utilizando estatística kappa e a validade do construto pela correlação tau de Kendall com outras variáveis. A estabilidade teste-reteste foi discreta a moderada e as correlações, compatíveis com a teoria subjacente. Estudos futuros no contexto do ELSA-Brasil e em outras populações complementarão a avaliação da sua pertinência.

  2. [Routines of organization of clinical tests and interviews in the ELSA-Brasil investigation center].

    PubMed

    Bensenor, Isabela M; Griep, Rosane H; Pinto, Karina Araújo; Faria, Carolina Perim de; Felisbino-Mendes, Mariana; Caetano, Edna I; Albuquerque, Liliane da Silva; Schmidt, Maria Inês

    2013-06-01

    The ELSA-Brasil (Estudo Longitudinal de Saúde do Adulto - Brazilian Longitudinal Study for Adult Health) is a prospective cohort study with extensive assessments throughout time. This article describes the routine of clinical tests and interviews performed with participants and the structuring of the Research Center physical space and teams. The ELSA-Brasil assumes that participants will be present at the Research Center to have the tests and interviews performed, according to standard protocols developed by this study. Considering the multiplicity of activities involved, each with specific needs for standardization, several predetermined orders of clinical tests and interviews were created. This ensured a high standard of quality in data collection without harm to participants' comfort. Each participant was previously assigned to a specific sequence of clinical tests and interviews with a predefined arrival time, mean length of stay of five to six hours and departure time.

  3. Commissioning and initial experimental program of the BGO-OD experiment at ELSA

    NASA Astrophysics Data System (ADS)

    Alef, S.; Bauer, P.; Bayadilov, D.; Beck, R.; Becker, M.; Bella, A.; Bielefeldt, P.; Böse, S.; Braghieri, A.; Brinkmann, K.; Cole, P.; Di Salvo, R.; Dutz, H.; Elsner, D.; Fantini, A.; Freyermuth, O.; Friedrich, S.; Frommberger, F.; Ganenko, V.; Geffers, D.; Gervino, G.; Ghio, F.; Görtz, S.; Gridnev, A.; Gutz, E.; Hammann, D.; Hannappel, J.; Hillert, W.; Ignatov, A.; Jahn, R.; Joosten, R.; Jude, T. C.; Klein, F.; Knaust, J.; Kohl, K.; Koop, K.; Krusche, B.; Lapik, A.; Levi Sandri, P.; Lopatin, I. V.; Mandaglio, G.; Messi, F.; Messi, R.; Metag, V.; Moricciani, D.; Mushkarenkov, A.; Nanova, M.; Nedorezov, V.; Novinskiy, D.; Pedroni, P.; Reitz, B.; Romaniuk, M.; Rostomyan, T.; Rudnev, N.; Schaerf, C.; Scheluchin, G.; Schmieden, H.; Stugelev, A.; Sumachev, V.; Tarakanov, V.; Vegna, V.; Walther, D.; Watts, D.; Zaunick, H.; Zimmermann, T.

    2016-11-01

    BGO-OD is a new meson photoproduction experiment at the ELSA facility of Bonn University. It aims at the investigation of non strange and strange baryon excitations, and is especially designed to be able to detect weekly bound meson-baryon type structures. The setup for the BGO-OD experiment is presented, the characteristics of the photon beam and the detector performances are shown and the initial experimental program is discussed.

  4. Fixed-flexion knee radiography using a new positioning device produced highly repeatable measurements of joint space width: ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK).

    PubMed

    Telles, Rosa Weiss; Costa-Silva, Luciana; Machado, Luciana A C; Reis, Rodrigo Citton Padilha Dos; Barreto, Sandhi Maria

    To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA) in Brazilian Longitudinal Study of Adult Health Musculoskeletal Study (ELSA-Brasil MSK). A test-retest design including 19 adults (38 knee images) was conducted. Feasibility of the radiographic protocol was assessed by image quality parameters and presence of radioanatomic alignment according to intermargin distance (IMD) values. Repeatability was assessed for IMD and joint space width (JSW) measured at three different locations. Approximately 90% of knee images presented excellent quality. Frequencies of nearly perfect radioanatomic alignment (IMD ≤1mm) ranged from 29% to 50%, and satisfactory alignment was found in up to 71% and 76% of the images (IMD ≤1.5mm and ≤1.7mm, respectively). Repeatability analyses yielded the following results: IMD [SD of mean difference=1.08; coefficient of variation (%CV)=54.68%; intraclass correlation coefficient (ICC) (95%CI)=0.59 (0.34-0.77)]; JSW [SD of mean difference=0.34-0.61; %CV=4.48%-9.80%; ICC (95%CI)=0.74 (0.55-0.85)-0.94 (0.87-0.97)]. Adequately reproducible measurements of IMD and JSW were found in 68% and 87% of the images, respectively. Despite the difficulty in achieving consistent radioanatomic alignment between subsequent radiographs in terms of IMD, the protocol produced highly repeatable JSW measurements when these were taken at midpoint and 10mm from the medial extremity of the medial tibial plateau. Therefore, measurements of JSW at these locations can be considered adequate for the assessment of knee OA in ELSA-Brasil MSK. Copyright © 2016. Published by Elsevier Editora Ltda.

  5. Fixed-flexion knee radiography using a new positioning device produced highly repeatable measurements of joint space width: ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK).

    PubMed

    Telles, Rosa Weiss; Costa-Silva, Luciana; Machado, Luciana A C; Reis, Rodrigo Citton Padilha Dos; Barreto, Sandhi Maria

    2016-11-26

    To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA) in ELSA-Brasil MSK. A test-retest design including 19 adults (38 knee images) was conducted. Feasibility of the radiographic protocol was assessed by image quality parameters and presence of radioanatomic alignment according to intermargin distance (IMD) values. Repeatability was assessed for IMD and joint space width (JSW) measured at three different locations. Approximately 90% of knee images presented excellent quality. Frequencies of nearly perfect radioanatomic alignment (IMD ≤1mm) ranged from 29% to 50%, and satisfactory alignment was found in up to 71% and 76% of the images (IMD ≤1.5mm and ≤1.7mm, respectively). Repeatability analyses yielded the following results: IMD [SD of mean difference=1.08; coefficient of variation (%CV)=54.68%; intraclass correlation coefficient (ICC) (95%CI)=0.59 (0.34-0.77)]; JSW [SD of mean difference=0.34 - 0.61; %CV=4.48% - 9.80%; ICC (95%CI)=0.74 (0.55-0.85) - 0.94 (0.87-0.97)]. Adequately reproducible measurements of IMD and JSW were found in 68% and 87% of the images, respectively. Despite the difficulty in achieving consistent radioanatomic alignment between subsequent radiographs in terms of IMD, the protocol produced highly repeatable JSW measurements when these were taken at midpoint and 10mm from the medial extremity of the medial tibial plateu. Therefore, measurements of JSW at these locations can be considered adequate for the assessment of knee OA in ELSA-Brasil MSK. Copyright © 2016. Published by Elsevier Editora Ltda.

  6. Target asymmetry measurements of {gamma} p{r_arrow}{pi} {sup +}n with Phoenics at ELSA

    SciTech Connect

    Althoff, K.; Anton, G.; Arends, J.; Beulertz, W.; Bock, A.; Breuer, M.; Detemple, P.; Dutz, H.; Gehring, R.; Gemander, M.; Goertz, S.; Helbing, K.; Hey, J.; Kraemer, D.; Meyer, W.; Noeldeke, G.; Reicherz, G.; Thomas, A.; Zucht, B.

    1995-05-10

    The target asymmetry T of the reaction {gamma} p{r_arrow}{pi} {sup +}n has been measured with the Phoenics detector in combination with the Bonn frozen spin target at ELSA. For the first time the polarization observable T has been determined simultaneously over a large photon energy range (E{sub {gamma}}=220--800 MeV) and pion angles ({Theta}{sub {pi}}{sup m}=35{degree}--135{degree}) with a tagged photon facility. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  7. Mapping Van

    NASA Technical Reports Server (NTRS)

    1994-01-01

    A NASA Center for the Commercial Development of Space (CCDS) - developed system for satellite mapping has been commercialized for the first time. Global Visions, Inc. maps an area while driving along a road in a sophisticated mapping van equipped with satellite signal receivers, video cameras and computer systems for collecting and storing mapping data. Data is fed into a computerized geographic information system (GIS). The resulting amps can be used for tax assessment purposes, emergency dispatch vehicles and fleet delivery companies as well as other applications.

  8. The Emotional Literacy Support Assistant (ELSA) Programme: Parental Perceptions of Its Impact in School and at Home

    ERIC Educational Resources Information Center

    Wilding, Lucy; Claridge, Simon

    2016-01-01

    The Emotional Literacy Support Assistant (ELSA) programme is an example of an individualised intervention to support pupils experiencing a range of social and emotional needs. Semi-structured interviews were conducted to explore parents' constructions of several aspects of the programme: its aims and how these are achieved; its impact on children,…

  9. The ELSA tephra stack: Volcanic activity in the Eifel during the last 500,000 years

    NASA Astrophysics Data System (ADS)

    Förster, Michael W.; Sirocko, Frank

    2016-07-01

    Tephra layers of individual volcanic eruptions are traced in several cores from Eifel maar lakes, drilled between 1998 and 2014 by the Eifel Laminated Sediment Archive (ELSA). All sediment cores are dated by 14C and tuned to the Greenland interstadial succession. Tephra layers were characterized by the petrographic composition of basement rock fragments, glass shards and characteristic volcanic minerals. 10 marker tephra, including the well-established Laacher See Tephra and Dümpelmaar Tephra can be identified in the cores spanning the last glacial cycle. Older cores down to the beginning of the Elsterian, show numerous tephra sourced from Strombolian and phreatomagmatic eruptions, including the 40Ar/39Ar dated differentiated tephra from Glees and Hüttenberg. In total, at least 91 individual tephra can be identified since the onset of the Eifel volcanic activity at about 500,000 b2k, which marks the end of the ELSA tephra stack with 35 Strombolian, 48 phreatomagmatic and 8 tephra layers of evolved magma composition. Many eruptions cluster near timings of the global climate transitions at 140,000, 110,000 and 60,000 b2k. In total, the eruptions show a pattern, which resembles timing of phases of global sea level and continental ice sheet changes, indicating a relation between endogenic and exogenic processes.

  10. Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): objectives and design.

    PubMed

    Aquino, Estela M L; Barreto, Sandhi Maria; Bensenor, Isabela M; Carvalho, Marilia S; Chor, Dóra; Duncan, Bruce B; Lotufo, Paulo A; Mill, José Geraldo; Molina, Maria Del Carmen; Mota, Eduardo L A; Passos, Valéria Maria Azeredo; Schmidt, Maria Inês; Szklo, Moyses

    2012-02-15

    Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.

  11. Single π0 and ɛ Photoproduction off the Proton at CB-ELSA

    NASA Astrophysics Data System (ADS)

    Bartholomy, Olivia

    2004-08-01

    Photoproduction of mesons provides an opportunity to access the properties of nucleon resonances. The study is complementary to πN scattering from which most known properties of resonances have been extracted. Many resonances predicted by quark model calculations have not been observed experimentally or are only weakly established. Photoproduction of mesons offers an additional tool to study the baryon spectrum, to gain information about masses, couplings, and decay widths of the contributing resonances. In 2001, during its first period of taking data at the electron accelerator ELSA in Bonn, the CB-ELSA experiment gathered a large amount of high-quality data on meson photoproduction off the proton. The detector system is ideally suited for measuring photoproduction reactions with neutral mesons in the final state over the full angular range and at high energies. Differential cross sections of γp → pπ0 and γp → pη have been extracted for incident photon energies up to E γ = 3 GeV. At low energies, results of the TAPS, GRAAL, and CLAS experiments are well reproduced. New data points were added for forward angles of the meson and at energies above 2 GeV.

  12. Eating patterns in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): an exploratory analysis.

    PubMed

    Cardoso, Letícia de Oliveira; Carvalho, Marilia Sá; Cruz, Oswaldo Gonçalves; Melere, Cristiane; Luft, Vivian Cristine; Molina, Maria Del Carmen Bisi; Faria, Carolina Perim de; Benseñor, Isabela M; Matos, Sheila Maria Alvim; Fonseca, Maria de Jesus Mendes da; Griep, Rosane Harter; Chor, Dóra

    2016-01-01

    The food consumption of 15,071 public employees was analyzed in six Brazilian cities participating in the baseline for Brazilian Longitudinal Study of Adult Health (ELSA-Brasil, 2008-2010) with the aim of identifying eating patterns and their relationship to socio-demographic variables. Multiple correspondence and cluster analysis were applied. Four patterns were identified, with their respective frequencies: "traditional" (48%); "fruits and vegetables" (25%); "pastry shop" (24%); and "diet/light" (5%) The "traditional" and "pastry shop" patterns were more frequent among men, younger individuals, and those with less schooling. "Fruits and vegetables" and "diet/light" were more frequent in women, older individuals, and those with more schooling. Our findings show the inclusion of new items in the "traditional" pattern and the appearance of the "low sugar/low fat" pattern among the eating habits of Brazilian workers, and signal socio-demographic and regional differences.

  13. ELSA flood stack for MIS 2-3 from dry maar lakestructure Auel (Eifel/Germany)

    NASA Astrophysics Data System (ADS)

    Brunck, Heiko; Sirocko, Frank

    2015-04-01

    Lacustrine sediments are very sensitive to natural and anthropogenically enviromental changes. Thus, lake sediments are excellent climate archives and can be used for reconstructions of past precipitation and flood events. However, until now, there is no continous flood record for the entire last 60 000 years for Central Europe. The present study reconstructs paleo floods from event layers in the sediment, of dry maar lakestructure Auel (Eifel). This silted up basin has an inflow by a local stream. Accordingly the sedimentation rate is directly linked to runoff activity. The bioturbation was low so that event layers become visible, but varves are not preserved. The maar site is near to the town of Gerolstein in the Eifel; the core AU2 was drilled in the ELSA (Eifel Laminated Sediment archive) project and is 123m long. AU2 has the highest sedimentation rate of all ELSA cores, due to abundant fluvial input. The Eifel area is well suited to approximate Central European weather, because modern water level gauge data from Eifel rivers correlate with respective data from the Rhine (Wernli and Pfahl, 2009). Due to the high inflow into the maar, Auel has the highest number of botanical macro remains of all ELSA cores. These specific conditions explain why only in AU2 all 21 Greenland interstadials can be observed in the abundance of wood remains and the organic carbon concentration. In a final stratigraphic step the time series of Corg was tuned to the Greenland ice core chronology to link the central European landscape evolution directly to the Greenland climate curve (Svensson et al., 2008). Combined sedimentological, paleobotanical and geochemical data received from AU2 builds the foundation of the 14C based chronology. The synchronisation of the record with other cores is controlled by tephra time markers and pollen. Both are used to align the main cores of the ELSA project and construct an integrated age model for the last 220 000 years [b2k] (Förster and Sirocko

  14. Polarised Photon Beams for the BGO-OD Experiment at ELSA

    NASA Astrophysics Data System (ADS)

    Zimmermann, T.; Bella, A.; Alef, S.; Bayadilov, D.; Beck, R.; Becker, M.; Bielefeldt, P.; Boese, S.; Braghieri, A.; Brinkmann, K.; Cole, P.; Curciarello, F.; De Leo, V.; Di Salvo, R.; Dutz, H.; Elsner, D.; Fantini, A.; Freyermuth, O.; Friedrich, S.; Frommberger, F.; Ganenko, V.; Gervino, G.; Ghio, F.; Giardina, G.; Goertz, S.; Gridnev, A.; Gutz, E.; Hammann, D.; Hannappel, J.; Hartmann, P.; Hillert, W.; Ignatov, A.; Jahn, R.; Joosten, R.; Jude, T. C.; Klein, F.; Koop, K.; Krusche, B.; Lapik, A.; Levi Sandri, P.; Lopatin, I. V.; Mandaglio, G.; Messi, F.; Messi, R.; Metag, V.; Moricciani, D.; Mushkarenkov, A.; Nanova, M.; Nedorezov, V.; Novinskiy, D.; Pedroni, P.; Reitz, B.; Romaniuk, M.; Rostomyan, T.; Rudnev, N.; Schaerf, C.; Scheluchin, G.; Schmieden, H.; Stugelev, A.; Sumachev, V.; Tarakanov, V.; Vegna, V.; Walther, D.; Watts, D.; Zaunick, H.

    The new BGO-OD experiment at the electron accelerator ELSA, of the University of Bonn, is designed to study the reaction dynamics of nucleon excitations in meson photoproduction. It consists of a central BGO calorimeter with a magnetic spectrometer in forward direction. The physics programme includes the measurement of polarisation observables using linearly and circularly polarised photon beams. Linear polarisation is obtained by coherent bremsstrahlung off a diamond crystal, and circular polarisation is obtained via bremsstrahlung from longitudinally polarised electrons. The degree of linear polarisation is determined from the bremsstrahlung spectrum itself. To determine the polarisation of the circularly polarised photon beam, the polarisation of the electron beam is measured by a Møller polarimeter. As a preliminary consistency check, the (linear) polarisation observable, Σ, was compared to world data for π0 and η photoproduction. To determine the degree of circular polarisation, a Møller polarimeter was setup and first measurements of the electron beam polarisation performed.

  15. Reproducibility of Left Ventricular Mass by Echocardiogram in the ELSA-Brasil

    PubMed Central

    Tognon, Alexandre Pereira; Foppa, Murilo; Luft, Vivian Cristine; Chambless, Lloyd Ellwood; Lotufo, Paulo; El Aouar, Lilia Maria Mameri; Fernandes, Luciana Pereira; Duncan, Bruce Bartholow

    2015-01-01

    Background Echocardiography, though non-invasive and having relatively low-cost, presents issues of variability which can limit its use in epidemiological studies. Objective To evaluate left ventricular mass reproducibility when assessed at acquisition (online) compared to when assessed at a reading center after electronic transmission (offline) and also when assessed by different readers at the reading center. Methods Echocardiographers from the 6 ELSA-Brasil study investigation centers measured the left ventricular mass online during the acquisition from 124 studies before transmitting to the reading center, where studies were read according to the study protocol. Half of these studies were blindly read by a second reader in the reading center. Results From the 124 echocardiograms, 5 (4%) were considered not measurable. Among the remaining 119, 72 (61%) were women, mean age was 50.2 ± 7.0 years and 2 had structural myocardial abnormalities. Images were considered to be optimal/ good by the reading center for 110 (92.4%) cases. No significant difference existed between online and offline measurements (1,29 g, CI 95% −3.60-6.19), and the intraclass correlation coefficient between them was 0.79 (CI 95% 0.71-0.85). For images read by two readers, the intraclass correlation coefficient was 0.86 (CI 95% 0.78-0.91). Conclusion There were no significant drifts between online and offline left ventricular mass measurements, and reproducibility was similar to that described in previous studies. Central quantitative assessment of echocardiographic studies in reading centers, as performed in the ELSA-Brasil study, is feasible and useful in clinical and epidemiological studies performed in our setting. PMID:25424165

  16. [Experience of importation of equipment for research in the ELSA-Brasil].

    PubMed

    Almeida, Cristiana Paula Matos de; Aquino, Estela M L; Mota, Eduardo L A; Mota, Fábio Batista; Braga, Valéria Cerqueira Campos; Ladeira, Roberto Marini; Silva, Gabriela Feiden; Souza, Angelita Gomes de; Oliveira, Rosalba

    2013-06-01

    Policies that promote research in health were established in the last decade, developing the Brazilian scientific production. This development has not been accompanied by an improvement in the legal-institutional framework, thus hindering the development of research projects, including equipment importation activities. The present study aimed to analyze the equipment importation process for the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil). A case study was performed with data collected from internal ELSA-Brasil documents in five Investigation Centers and their respective supporting foundations. The following importation documents were analyzed: pulse wave velocity, bioimaging and retinography. Additionally, non-structured interviews with researchers and key informers were conducted in the foundations. Data were treated and organized into three stages: administrative-operational, exchange rate, and fiscal. Lengths of duration of these stages were calculated comparatively among centers. The need to standardize equipment in a multicenter study required a joint action of implementing institutions and foundations. Of all pieces of equipment analyzed, the first stage was administrative-operational, with a varying duration (minimum of eight, maximum of 101, and mean of 55 days) which was longer when legal opinions were included. The second stage was the exchange rate, which was longer than the former and did not pose any obstacles to the process (minimum of 11, maximum of 381, and mean of 196 days). The third stage was fiscal, which was the longest one (minimum of 43, maximum of 388, and mean of 215.5 days), due to the release of equipment without registration into the country. There were other factors that posed obstacles: inexperience of investigation centers and institutions in networking; inadequacy of the national legislation on scientific research particularities; and the lack of specialized professionals in scientific project management. The results

  17. [Reproducibility of arterial pressure measured in the ELSA-Brasil with 24-hour pressure monitoring].

    PubMed

    Nascimento, Larissa Rangel; Molina, Maria del Carmen Bisi; Faria, Carolina Perim; Cunha, Roberto de Sá; Mill, José Geraldo

    2013-06-01

    To determine the reproducibility of casual arterial pressure measurement and to confirm pressure diagnosis by monitoring of participants in the ELSA-Brasil (Estudo Longitudinal de Saúde do Adulto - Brazilian Longitudinal Study for Adult Health). Casual blood pressure was measured with an oscilometric device. A sub-sample of participants (N = 255) from Espírito Santo state (Southeastern Brazil) was reevaluated using the same methodology following one to ten weeks and, in addition, underwent arterial blood pressure monitoring. Diagnosis of hypertension used cut off points of 140/90 mmHg for casual pressure and 130/80 mmHg for arterial blood pressure monitoring. White coat hypertension was defined as the presence of hypertension in casual blood pressure and normal arterial blood pressure monitoring, and converse findings characterized masked hypertension. Data are from 230 participants that on the two occasions were free from antihypertensive medication (N1 = 153) or under the same antihypertensive regimen (N2 = 77). Normotension was confirmed by arterial blood pressure monitoring in 120 out of 134 participants of the N1 group. In N2, blood pressure control was confirmed by arterial blood pressure monitoring in 43 of 54 participants with controlled hypertension per casual blood pressure. Overall diagnostic concordance between casual blood pressure and arterial blood pressure monitoring was 78% (kappa = 0.44). In the N1 group, six subjects (4%) presented white coat hypertension, and 23 subjects (25%) presented with masked hypertension. Diagnostic concordance between casual blood pressure and arterial blood pressure monitoring was moderate. The rigorous standardization of casual blood pressure measurement adopted in the ELSA-Brasil study was able to reduce white coat hypertension. The high frequency of masked hypertension may suggest that pressure values obtained by arterial blood pressure monitoring indicate an elevated degree of stress at work.

  18. Variability in baseline laboratory measurements of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    Ladwig, R.; Vigo, A.; Fedeli, L.M.G.; Chambless, L.E.; Bensenor, I.; Schmidt, M.I.; Vidigal, P.G.; Castilhos, C.D.; Duncan, B.B.

    2016-01-01

    Multi-center epidemiological studies must ascertain that their measurements are accurate and reliable. For laboratory measurements, reliability can be assessed through investigation of reproducibility of measurements in the same individual. In this paper, we present results from the quality control analysis of the baseline laboratory measurements from the ELSA-Brasil study. The study enrolled 15,105 civil servants at 6 research centers in 3 regions of Brazil between 2008–2010, with multiple biochemical analytes being measured at a central laboratory. Quality control was ascertained through standard laboratory evaluation of intra- and inter-assay variability and test-retest analysis in a subset of randomly chosen participants. An additional sample of urine or blood was collected from these participants, and these samples were handled in the same manner as the original ones, locally and at the central laboratory. Reliability was assessed with the intraclass correlation coefficient (ICC), estimated through a random effects model. Coefficients of variation (CV) and Bland-Altman plots were additionally used to assess measurement variability. Laboratory intra and inter-assay CVs varied from 0.86% to 7.77%. From test-retest analyses, the ICCs were high for the majority of the analytes. Notably lower ICCs were observed for serum sodium (ICC=0.50; 95%CI=0.31–0.65) and serum potassium (ICC=0.73; 95%CI=0.60–0.83), due to the small biological range of these analytes. The CVs ranged from 1 to 14%. The Bland-Altman plots confirmed these results. The quality control analyses showed that the collection, processing and measurement protocols utilized in the ELSA-Brasil produced reliable biochemical measurements. PMID:27533768

  19. Variability in baseline laboratory measurements of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Ladwig, R; Vigo, A; Fedeli, L M G; Chambless, L E; Bensenor, I; Schmidt, M I; Vidigal, P G; Castilhos, C D; Duncan, B B

    2016-08-01

    Multi-center epidemiological studies must ascertain that their measurements are accurate and reliable. For laboratory measurements, reliability can be assessed through investigation of reproducibility of measurements in the same individual. In this paper, we present results from the quality control analysis of the baseline laboratory measurements from the ELSA-Brasil study. The study enrolled 15,105 civil servants at 6 research centers in 3 regions of Brazil between 2008-2010, with multiple biochemical analytes being measured at a central laboratory. Quality control was ascertained through standard laboratory evaluation of intra- and inter-assay variability and test-retest analysis in a subset of randomly chosen participants. An additional sample of urine or blood was collected from these participants, and these samples were handled in the same manner as the original ones, locally and at the central laboratory. Reliability was assessed with the intraclass correlation coefficient (ICC), estimated through a random effects model. Coefficients of variation (CV) and Bland-Altman plots were additionally used to assess measurement variability. Laboratory intra and inter-assay CVs varied from 0.86% to 7.77%. From test-retest analyses, the ICCs were high for the majority of the analytes. Notably lower ICCs were observed for serum sodium (ICC=0.50; 95%CI=0.31-0.65) and serum potassium (ICC=0.73; 95%CI=0.60-0.83), due to the small biological range of these analytes. The CVs ranged from 1 to 14%. The Bland-Altman plots confirmed these results. The quality control analyses showed that the collection, processing and measurement protocols utilized in the ELSA-Brasil produced reliable biochemical measurements.

  20. Reproducibility of left ventricular mass by echocardiogram in the ELSA-Brasil.

    PubMed

    Tognon, Alexandre Pereira; Foppa, Murilo; Luft, Vivian Cristine; Chambless, Lloyd Ellwood; Lotufo, Paulo; El Aouar, Lilia Maria Mameri; Fernandes, Luciana Pereira; Duncan, Bruce Bartholow

    2015-02-01

    Echocardiography, though non-invasive and having relatively low-cost, presents issues of variability which can limit its use in epidemiological studies. To evaluate left ventricular mass reproducibility when assessed at acquisition (online) compared to when assessed at a reading center after electronic transmission (offline) and also when assessed by different readers at the reading center. Echocardiographers from the 6 ELSA-Brasil study investigation centers measured the left ventricular mass online during the acquisition from 124 studies before transmitting to the reading center, where studies were read according to the study protocol. Half of these studies were blindly read by a second reader in the reading center. From the 124 echocardiograms, 5 (4%) were considered not measurable. Among the remaining 119, 72 (61%) were women, mean age was 50.2 ± 7.0 years and 2 had structural myocardial abnormalities. Images were considered to be optimal/ good by the reading center for 110 (92.4%) cases. No significant difference existed between online and offline measurements (1,29 g, CI 95% -3.60-6.19), and the intraclass correlation coefficient between them was 0.79 (CI 95% 0.71-0.85). For images read by two readers, the intraclass correlation coefficient was 0.86 (CI 95% 0.78-0.91). There were no significant drifts between online and offline left ventricular mass measurements, and reproducibility was similar to that described in previous studies. Central quantitative assessment of echocardiographic studies in reading centers, as performed in the ELSA-Brasil study, is feasible and useful in clinical and epidemiological studies performed in our setting.

  1. [Logistics of collection and transportation of biological samples and the organization of the central laboratory in the ELSA-Brasil].

    PubMed

    Fedeli, Ligia G; Vidigal, Pedro G; Leite, Claudia Mendes; Castilhos, Cristina D; Pimentel, Robércia Anjos; Maniero, Viviane C; Mill, Jose Geraldo; Lotufo, Paulo A; Pereira, Alexandre C; Bensenor, Isabela M

    2013-06-01

    The ELSA (Estudo Longitudinal de Saúde do Adulto - Brazilian Longitudinal Study for Adult Health) is a multicenter cohort study which aims at the identification of risk factors associated with type 2 diabetes and cardiovascular diseases in the Brazilian population. The paper describes the strategies for the collection, processing, transportation, and quality control of blood and urine tests in the ELSA. The study decided to centralize the tests at one single laboratory. The processing of the samples was performed at the local laboratories, reducing the weight of the material to be transported, and diminishing the costs of transportation to the central laboratory at the Universidade de São Paulo Hospital. The study included tests for the evaluation of diabetes, insulin resistance, dyslipidemia, electrolyte abnormalities, thyroid hormones, uric acid, hepatic enzyme abnormalities, inflammation, and total blood cell count. In addition, leukocyte DNA, urine, plasma and serum samples were stored. The central laboratory performed approximately 375,000 tests.

  2. Electrocardiographic Findings in Brazilian Adults without Heart Disease: ELSA-Brasil.

    PubMed

    Pinto, Marcelo Martins; Brant, Luisa C C; Padilha-da-Silva, José Luiz; Foppa, Murilo; Lotufo, Paulo A; Mill, José Geraldo; Vasconcelo-Silva, Paulo R; Almeida, Maria da Conceição C; Barreto, Sandhi Maria; Ribeiro, Antônio Luiz Pinho

    2017-10-02

    The electrocardiogram (ECG) is widely used in population-based studies. However, there are few studies on electrocardiographic findings in Latin America and in Brazil. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) comprised 15,105 participants (35-74 years) from six Brazilian capitals. To describe electrocardiographic findings in Brazilian adults without heart disease, stratified by sex, age and race/skin color. Cross-sectional study with baseline data of 11,094 adults (44.5% men) without heart disease from ELSA-Brasil. The ECGs were recorded with the Burdick Atria 6100 machine and stored at the Pyramis System. ECG analysis was automatically performed using the Glasgow University software. A descriptive analysis of heart rate (HR), P, QRS and T waves' duration, PR and QT intervals, and P, R and T axes was performed. After stratification by sex, race/color and age, the groups were compared by the Wilcoxon and Kruskal-Wallis test at a significance level of 5%. Linear regression models were used to evaluate the behavior of electrocardiographic parameters over age. Major electrocardiographic abnormalities defined by the Minnesota code were manually revised. Medians values of the electrocardiographic parameters were different between men and women: HR 63 vs. 66 bpm, PR 164 vs.158 ms, QT corrected 410 vs. 421 ms, QRS duration 92 vs. 86 ms, P-wave duration 112 vs. 108 ms, P-wave axis 54 vs. 57 degrees, R-wave axis 35 vs. 39 degrees, T-wave axis 39 vs. 45 degrees (p < 0.001 for all). The 2nd and the 98th percentiles of each variable were also obtained, and graphs were constructed to illustrate the behavior of the electrocardiographic findings over age of participants stratified by sex and race/skin color. The values for the electrocardiographic measurements herein described can be used as reference for Brazilian adults free of heart disease, stratified by sex. Our results suggest that self-reported race/skin color have no significant influence on

  3. Baryon spectroscopy: Recent results from the Crystal Barrel/TAPS experiment at ELSA

    SciTech Connect

    Thoma, U.

    2010-08-05

    To understand the spectrum and the properties of baryon resonances, the CBELSA/TAPS experiment at ELSA investigates the photoproduction of single- and multi-meson final states off the nucleon. In the latter final states baryon cascades via Dp and Dh and also via higher mass baryon resonances are clearly observed. A partial wave analysis based on single and double meson photoproduction data as well as data from other reactions allows a first determination of resonance properties including partial decay widths of various N* and {Delta}* states. Those include also the decays into the different p{pi}{sup 0{pi}0} and p{pi}{sup 0{eta}} decay channels resulting partly in unexpected results. Recently not only single but also double polarisation experiments have been performed, which are absolutelly necessary to resolve ambiguities in the partial wave analyses (PWA) used to extract the resonances from the data; without the measurement of polarisation observables a model-independent PWA will not be possible. Polarisation observables have been investigated using linearly, circularly polarized or unpolarized photons impinging on an longitudinally polarized or unpolarized target. Given the angular coverage of the Crystal-Barrel/TAPS experiment this data cover almost the full angular range and phase space. This data will provide key information for the partial wave analyses and brings us one step closer towards the needed complete experiment.

  4. Wealth and Disability in Later Life: The English Longitudinal Study of Ageing (ELSA)

    PubMed Central

    Torres, Juliana Lustosa; Lima-Costa, Maria Fernanda; Marmot, Michael; de Oliveira, Cesar

    2016-01-01

    We examined wealth inequalities in disability, taking into account the effect of both depression and social support among older English adults using data from 5,506 community-dwelling people aged 50 years and over from the English Longitudinal Study of Ageing (ELSA). Disability was measured as self-reported limitations in the Basic Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL). Depressive symptomatology was measured using the 8-item Center for Epidemiological Studies-Depression (CES-D) scale. Social support was assessed by marital status and frequency of contact with friends, relatives or children. Multinomial logistic regression models were used to assess the role of social support and depressive symptoms on disability by total household wealth, which is a measure of accumulated assets over the course of life. Our findings showed that the poorest men with disability were more likely to live without a partner and have no weekly contact with children, family or friends compared to the wealthiest. Among women with disability, the poorest were more likely to report loneliness and have no partner while the wealthiest and the intermediate groups were more likely to be living with a partner. There was a strong inverse dose-response association between wealth and depressive symptoms among all participants with disability. This study shows a clear wealth gradient in disability among older English adults, especially for those with elevated depressive symptoms. PMID:27875579

  5. Factors associated with leisure time physical activity among ELSA-Brasil participants: Ecological model.

    PubMed

    Pitanga, Francisco José Gondim; Matos, Sheila Maria Alvim; Almeida, Maria da Conceição; Molina, Maria Del Carmen Bisi; Aquino, Estela M L

    2016-09-01

    The main objective of the study was identify the prevalence and factors associated with leisure time physical activity (LTPA) in adult participants of the Longitudinal Study of Adult Health (ELSA-Brasil). The LTPA was measured using the International Physical Activity Questionnaire (IPAQ), long version. A hierarchical ecological model was built with the possible factors associated with LTPA distributed across blocks. We estimated crude and adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression. In men, being more educated, having a high family income, living in environments with conditions and opportunities for PA, being retired and being overweight were positively associated, while current smoking, obesity and abdominal obesity were associated negatively with the LTPA. Among women, being over 60years old, being more educated, having a high family income, living in an environment with conditions and opportunities for PA practice and being retired were positively associated, while being overweight, obese and having abdominal obesity were associated negatively with the LTPA. The proposed ecological model explains the LTPA through the social, physical and personal environment and highlights gender differences in physical activity.

  6. Relation of Anxiety and Depressive Symptoms to Coronary Artery Calcium (from the ELSA-Brasil Baseline Data).

    PubMed

    Santos, Itamar S; Bittencourt, Marcio S; Rocco, Priscila T; Pereira, Alexandre C; Barreto, Sandhi M; Brunoni, André R; Goulart, Alessandra C; Blaha, Michael J; Lotufo, Paulo A; Bensenor, Isabela M

    2016-07-15

    Previous studies of the association between symptoms of anxiety or depression and coronary artery calcium (CAC) have produced heterogeneous results. Our aim was to investigate whether psychopathological symptoms were associated with CAC in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline. We analyzed data from 4,279 ELSA-Brasil subjects (aged 35 to 74 years) from the São Paulo site without previous cardiovascular disease who underwent CAC score assessment at baseline. Prevalent CAC was defined as a CAC score >0. Anxiety and depressive symptoms were assessed using the Clinical Interview Schedule-Revised (CIS-R). We built binary logistic regression models to determine whether CIS-R scores, anxiety, or depression were associated with prevalent CAC. Prevalent CAC was found in 1,211 subjects (28.3%). After adjustment for age and gender, a direct association between CIS-R scores and prevalent CAC was revealed (odds ratio for 1-SD increase: 1.12; 95% confidence interval [CI] 1.04 to 1.22). This association persisted after multivariate adjustment (odds ratio for 1-SD increase 1.11; 95% CI 1.02 to 1.20). No independent associations were found for specific diagnoses of anxiety or depression and prevalent CAC. In post hoc models, a significant interaction term (p = 0.019) suggested a stronger association in older subjects. In conclusion, psychopathological symptoms were directly associated with coronary atherosclerosis in the ELSA-Brasil baseline in adjusted models, and this association seems to be stronger in older subjects. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Physical Activity and Lipid Profile in the ELSA-Brasil Study

    PubMed Central

    da Silva, Raquel Caroline; Diniz, Maria de Fátima Haueisen Sander; Alvim, Sheila; Vidigal, Pedro Guatimosim; Fedeli, Ligia Maria Giongo; Barreto, Sandhi Maria

    2016-01-01

    Background Regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases. However, doubts whether intensity and duration have equivalent benefits remain. Objective To assess the association of PA intensity and duration with HDL, LDL and TG levels. Methods Cross-sectional study with 12,688 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline, who were not on lipid-lowering medication. After adjustment for important covariates, multiple linear regression was used to assess the association of PA intensity and duration with HDL, LDL and TG (natural logarithm) levels. Results Both moderate and vigorous PA and PA practice ≥ 150 min/week were significantly associated with higher HDL and lower TG levels. Vigorous PA was associated with lower LDL only on univariate analysis. After adjustments, moderate and vigorous PA increased mean HDL level by 0.89 mg/dL and 1.71 mg/dL, respectively, and reduced TG geometric mean by 0.98 mg/dL and 0.93 mg/dL, respectively. PA practice ≥ 150 min/week increased mean HDL level by 1.05 mg/dL, and decreased TG geometric mean by 0.98 mg/dL. Conclusion Our findings reinforce the benefits of both PA parameters studied on HDL and TG levels, with a slight advantage for vigorous PA as compared to the recommendation based only on PA duration. PMID:27355470

  8. Revisiting van Hiele

    ERIC Educational Resources Information Center

    Papademetri-Kachrimani, Chrystalla

    2012-01-01

    In this paper I argue my opposition to the consensus which has dominated the literature that young children view shapes as a whole and pay no attention to shape structure and that geometrical thinking can be described through a hierarchical model formed by levels. This consensus is linked to van Hiele's weok by van Hiele-based research. In the…

  9. Common mental disorders and sociodemographic characteristics: baseline findings of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Nunes, Maria A; Pinheiro, Andréa P; Bessel, Marina; Brunoni, André R; Kemp, Andrew H; Benseñor, Isabela M; Chor, Dora; Barreto, Sandhi; Schmidt, Maria I

    2016-01-01

    To assess the prevalence of common mental disorders (CMD) and the association of CMD with sociodemographic characteristics in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort. We analyzed data from the cross-sectional baseline assessment of the ELSA-Brasil, a cohort study of 15,105 civil servants from six Brazilian cities. The Clinical Interview Schedule-Revised (CIS-R) was used to investigate the presence of CMD, with a score ≥ 12 indicating a current CMD (last week). Specific diagnostic algorithms for each disorder were based on the ICD-10 diagnostic criteria. Prevalence ratios (PR) of the association between CMD and sociodemographic characteristics were estimated by Poisson regression. CMD (CIS-R score ≥ 12) was found in 26.8% (95% confidence intervals [95%CI] 26.1-27.5). The highest burden occurred among women (PR 1.9; 95%CI 1.8-2.0), the youngest (PR 1.7; 95%CI 1.5-1.9), non-white individuals, and those without a university degree. The most frequent diagnostic category was anxiety disorders (16.2%), followed by depressive episodes (4.2%). The burden of CMD was high, particularly among the more socially vulnerable groups. These findings highlight the need to strengthen public policies aimed to address health inequities related to mental disorders.

  10. Subclinical thyroid dysfunction and psychiatric disorders: cross-sectional results from the Brazilian Study of Adult Health (ELSA-Brasil).

    PubMed

    Benseñor, Isabela M; Nunes, Maria Angélica; Sander Diniz, Maria de Fátima; Santos, Itamar S; Brunoni, André R; Lotufo, Paulo A

    2015-01-12

    To evaluate the association between subclinical thyroid dysfunction and psychiatric disorders using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cross-sectional study. The study included 12 437 participants from the ELSA-Brasil with normal thyroid function (92·8%), 193 (1·4%) with subclinical hyperthyroidism and 784 (5·8%) with subclinical hypothyroidism, totalling 13 414 participants (50·6% of women). The mental health diagnoses of participants were assessed by trained raters using the Clinical Interview Schedule - Revised (CIS-R) and grouped according to the International Classification of Diseases 10 (ICD-10). Thyroid dysfunction was assessed using TSH and FT4 as well as routine use of thyroid hormones or antithyroid medications. Logistic models were presented using psychiatric disorders as the dependent variable and subclinical thyroid disorders as the independent variable. All logistic models were corrected for multiple comparisons using Bonferroni correction. After multivariate adjustment for possible confounders, we found a direct association between subclinical hyperthyroidism and panic disorder odds ratio [OR], 2·55; 95% confidence Interval (95% CI), 1·09-5·94; and an inverse association between subclinical hypothyroidism and generalized anxiety disorder (OR, 0·75; 95% CI, 0·59-0·96). However, both lost significance after correction for multiple comparisons. Subclinical hyperthyroidism was positively associated with panic disorder and negatively associated with anxiety disorder, although not significant after adjustment for multiple comparisons. © 2015 John Wiley & Sons Ltd.

  11. Timing and Type of Alcohol Consumption and the Metabolic Syndrome - ELSA-Brasil

    PubMed Central

    Vieira, Bruna Angelo; Luft, Vivian Cristine; Schmidt, Maria Inês; Chambless, Lloyd Ellwood; Chor, Dora; Barreto, Sandhi Maria; Duncan, Bruce Bartholow

    2016-01-01

    The prevalence of the metabolic syndrome is rising worldwide. Its association with alcohol intake, a major lifestyle factor, is unclear, particularly with respect to the influence of drinking with as opposed to outside of meals. We investigated the associations of different aspects of alcohol consumption with the metabolic syndrome and its components. In cross-sectional analyses of 14,375 active or retired civil servants (aged 35–74 years) participating in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we fitted logistic regression models to investigate interactions between the quantity of alcohol, the timing of its consumption with respect to meals, and the predominant beverage type in the association of alcohol consumption with the metabolic syndrome. In analyses adjusted for age, sex, educational level, income, socioeconomic status, ethnicity, smoking, body mass index, and physical activity, light consumption of alcoholic beverages with meals was inversely associated with the metabolic syndrome (≤4 drinks/week: OR = 0.85, 95%CI 0.74–0.97; 4 to 7 drinks/week: OR = 0.75, 95%CI 0.61–0.92), compared to abstention/occasional drinking. On the other hand, greater consumption of alcohol consumed outside of meals was significantly associated with the metabolic syndrome (7 to 14 drinks/week: OR = 1.32, 95%CI 1.11–1.57; ≥14 drinks/week: OR = 1.60, 95%CI 1.29–1.98). Drinking predominantly wine, which occurred mostly with meals, was significantly related to a lower syndrome prevalence; drinking predominantly beer, most notably when outside of meals and in larger quantity, was frequently associated with a greater prevalence. In conclusion, the alcohol—metabolic syndrome association differs markedly depending on the relationship of intake to meals. Beverage preference—wine or beer—appears to underlie at least part of this difference. Notably, most alcohol was consumed in metabolically unfavorable type and timing. If further investigations

  12. Timing and Type of Alcohol Consumption and the Metabolic Syndrome - ELSA-Brasil.

    PubMed

    Vieira, Bruna Angelo; Luft, Vivian Cristine; Schmidt, Maria Inês; Chambless, Lloyd Ellwood; Chor, Dora; Barreto, Sandhi Maria; Duncan, Bruce Bartholow

    2016-01-01

    The prevalence of the metabolic syndrome is rising worldwide. Its association with alcohol intake, a major lifestyle factor, is unclear, particularly with respect to the influence of drinking with as opposed to outside of meals. We investigated the associations of different aspects of alcohol consumption with the metabolic syndrome and its components. In cross-sectional analyses of 14,375 active or retired civil servants (aged 35-74 years) participating in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we fitted logistic regression models to investigate interactions between the quantity of alcohol, the timing of its consumption with respect to meals, and the predominant beverage type in the association of alcohol consumption with the metabolic syndrome. In analyses adjusted for age, sex, educational level, income, socioeconomic status, ethnicity, smoking, body mass index, and physical activity, light consumption of alcoholic beverages with meals was inversely associated with the metabolic syndrome (≤4 drinks/week: OR = 0.85, 95%CI 0.74-0.97; 4 to 7 drinks/week: OR = 0.75, 95%CI 0.61-0.92), compared to abstention/occasional drinking. On the other hand, greater consumption of alcohol consumed outside of meals was significantly associated with the metabolic syndrome (7 to 14 drinks/week: OR = 1.32, 95%CI 1.11-1.57; ≥14 drinks/week: OR = 1.60, 95%CI 1.29-1.98). Drinking predominantly wine, which occurred mostly with meals, was significantly related to a lower syndrome prevalence; drinking predominantly beer, most notably when outside of meals and in larger quantity, was frequently associated with a greater prevalence. In conclusion, the alcohol-metabolic syndrome association differs markedly depending on the relationship of intake to meals. Beverage preference-wine or beer-appears to underlie at least part of this difference. Notably, most alcohol was consumed in metabolically unfavorable type and timing. If further investigations extend these

  13. Maternal education, anthropometric markers of malnutrition and cognitive function (ELSA-Brasil)

    PubMed Central

    2014-01-01

    Background The early exposure to poor social and nutritional conditions may influence cognitive function during adult age. However, the relative impact of these factors has not yet been established and they can vary during the course of life. Methods Analysis of data from 12,997 participants (35-64 years) of the baseline exams (2008-2010) of the Longitudinal Study of Adult Health (ELSA-Brasil), a cohort of Brazilian civil servants. Four cognitive tests were applied: learning, recall and word recognition; semantic and phonemic verbal fluency; trail-making test version B. The markers of early nutritional and social conditions were maternal educational level, birth weight, and length of trunk and leg. The presence of independent association between every early marker and the poor performance in each cognitive test was investigated by multiple logistic regression, after mutual adjustment and considering the effects of gender, age and participant’s schooling level. The cut off for poor performance was the worst age-specific percentile of the final score distribution for each test. Results After full adjustments, lower maternal education increased the chances of poor performance in all cognitive tests, with a dose-response gradient; low birth-weight was related to poor performance in the trail-making test B (OR = 1.63, 95% IC = 1.29-2.06); and greater trunk length decreased the chances of poor performance in the semantic and phonemic verbal fluency (OR = 0.96, 95% IC = 0.94-0.97) and in the trail-making test B (OR = 0.94, 95% IC = 0.92-0.95). Leg length was not associated with any of the tests examined. The associations found were not modified by the educational attainment of the participants. Conclusions Early exposure to adverse social and nutritional conditions appear detrimental to semantic memory, learning, concentration, executive control and language among adults, independent of adulthood educational achievement. PMID:24989981

  14. Van Gogh Sun

    NASA Image and Video Library

    Nicholeen Viall, a solar scientist at NASA's Goddard Space Flight Center creates images of the sun reminiscent of Van Gogh, but it's science, not art. The color of each pixel contains a wealth of i...

  15. VAN method lacks validity

    NASA Astrophysics Data System (ADS)

    Jackson, David D.; Kagan, Yan Y.

    Varotsos and colleagues (the VAN group) claim to have successfully predicted many earthquakes in Greece. Several authors have refuted these claims, as reported in the May 27,1996, special issue of Geophysical Research Letters and a recent book, A Critical Review of VAN [Lighthill 1996]. Nevertheless, the myth persists. Here we summarize why the VAN group's claims lack validity.The VAN group observes electrical potential differences that they call “seismic electric signals” (SES) weeks before and hundreds of kilometers away from some earthquakes, claiming that SES are somehow premonitory. This would require that increases in stress or decreases in strength cause the electrical variations, or that some regional process first causes the electrical signals and then helps trigger the earthquakes. Here we adopt their notation SES to refer to the electrical variations, without accepting any link to the quakes.

  16. Van Gogh in Arles.

    ERIC Educational Resources Information Center

    Wasserman, Burton

    1985-01-01

    Recently an outstanding cross-section of works from Van Gogh's Arlesian period was on exhibition at the Metropolitan Museum of Art in New York City. His works are discussed; some samples are included. (RM)

  17. Space Van system update

    NASA Astrophysics Data System (ADS)

    Cormier, Len

    1992-07-01

    The Space Van is a proposed commercial launch vehicle that is designed to carry 1150 kg to a space-station orbit for a price of $1,900,000 per flight in 1992 dollars. This price includes return on preoperational investment. Recurring costs are expected to be about $840,000 per flight. The Space Van is a fully reusable, assisted-single-stage-to orbit system. The most innovative new feature of the Space Van system is the assist-stage concept. The assist stage uses only airbreathing engines for vertical takeoff and vertical landing in the horizontal attitude and for launching the rocket-powered orbiter stage at mach 0.8 and an altitude of about 12 km. The primary version of the orbiter is designed for cargo-only without a crew. However, a passenger version of the Space Van should be able to carry a crew of two plus six passengers to a space-station orbit. Since the Space Van is nearly single-stage, performance to polar orbit drops off significantly. The cargo version should be capable of carrying 350 kg to a 400-km polar orbit. In the passenger version, the Space Van should be able to carry two crew members - or one crew member plus a passenger.

  18. Linearly polarised photons at ELSA and measurement of the beam asymmetry in η-photoproduction off the proton

    NASA Astrophysics Data System (ADS)

    Elsner, D.

    The beam asymmetry, Σ, was measured at ELSA with the Crystal-Barrel- and TAPS detector setup in the reaction γ p → η p using linearly polarised tagged photon beams, produced by coherent bremsstrahlung off a diamond. The crystal was oriented to provide polarised photons in the energy range E γ = 800 to 1400 MeV with the maximum polarisation of P γ = 49% obtained at 1305 MeV. Both dominant decay modes of the η into two photons and 3π 0 were used to extract the beam asymmetry from the azimuthal modulation of the cross section. The measurements cover the angular range Θ cm ≃ 50 - 150 degrees. Large asymmetries up to 80% are observed, in agreement with a previous measurement. The eta-MAID model and the Bonn-Gatchina partial wave analysis describe the measurements, but the required partial waves differ significantly.

  19. Body Image and Nutritional Status Are Associated with Physical Activity in Men and Women: The ELSA-Brasil Study

    PubMed Central

    Coelho, Carolina G.; Giatti, Luana; Molina, Maria D. C. B.; Nunes, Maria A. A.; Barreto, Sandhi M.

    2015-01-01

    The association of body image dissatisfaction and obesity with physical activity is likely to differ according to gender. To investigate this hypothesis, we conducted a cross-sectional study among the ELSA-Brasil cohort members aged 34–65 years (n = 13,286). The body image dissatisfaction was present even among normal weight individuals of both sexes and was associated with lesser chances of practicing moderate physical activity in women and intense physical activity in men. Men and women with central obesity were less prone to practice physical activity of high or moderate intensity. Overweight and obese men were more likely to report vigorous physical activity while obese women were less likely to report this level of physical activity. Body images as well as nutritional status are related to physical activity in both sexes, but the association with physical activity differs by gender. PMID:26035664

  20. Linearly polarised photon beams at ELSA and measurement of the beam asymmetry in π0_{} photoproduction off the proton

    NASA Astrophysics Data System (ADS)

    Elsner, D.; Bantes, B.; Bartholomy, O.; Bayadilov, D. E.; Beck, R.; Beloglazov, Y. A.; Castelijns, R.; Crede, V.; Ehmanns, A.; Essig, K.; Ewald, R.; Fabry, I.; Frommberger, F.; Fornet-Ponse, K.; Fuchs, M.; Funke, C.; Gridnev, A. B.; Gutz, E.; Hillert, W.; Höffgen, S.; Hoffmeister, P.; Horn, I.; Jaegle, I.; Junkersfeld, J.; Kalinowsky, H.; Klein, Frank; Klein, Friedrich; Klempt, E.; Konrad, M.; Kotulla, M.; Krusche, B.; Löhner, H.; Lopatin, I. V.; Lotz, J.; Lugert, S.; Menze, D.; Mertens, T.; Messchendorp, J. G.; Metag, V.; Morales, C.; Nanova, M.; Novinski, D. V.; Novotny, R.; Ostrick, M.; Pant, L. M.; van Pee, H.; Pfeiffer, M.; Sarantsev, A. V.; Schmidt, C.; Schmieden, H.; Schoch, B.; Shende, S.; Süle, A.; Sumachev, V. V.; Szczepanek, T.; Thoma, U.; Trnka, D.; Walther, D.; Weinheimer, C.; Wendel, C.

    2009-03-01

    At the electron accelerator ELSA a linearly polarised tagged photon beam is produced by coherent bremsstrahlung off a diamond crystal. Orientation and energy range of the linear polarisation can be deliberately chosen by accurate positioning of the crystal with a goniometer. The degree of polarisation is determined by the form of the scattered electron spectrum. Good agreement between experiment and expectations on the basis of the experimental conditions is obtained. Polarisation degrees of ensuremath P_{γ}=40 % are typically achieved at half of the primary electron energy. The determination of ensuremath P_{γ} is confirmed by measuring the beam asymmetry, Σ , in π0_{} photoproduction and by a comparison of the results to independent measurements using laser backscattering.

  1. Body Image and Nutritional Status Are Associated with Physical Activity in Men and Women: The ELSA-Brasil Study.

    PubMed

    Coelho, Carolina G; Giatti, Luana; Molina, Maria D C B; Nunes, Maria A A; Barreto, Sandhi M

    2015-05-29

    The association of body image dissatisfaction and obesity with physical activity is likely to differ according to gender. To investigate this hypothesis, we conducted a cross-sectional study among the ELSA-Brasil cohort members aged 34-65 years (n=13,286). The body image dissatisfaction was present even among normal weight individuals of both sexes and was associated with lesser chances of practicing moderate physical activity in women and intense physical activity in men. Men and women with central obesity were less prone to practice physical activity of high or moderate intensity. Overweight and obese men were more likely to report vigorous physical activity while obese women were less likely to report this level of physical activity. Body images as well as nutritional status are related to physical activity in both sexes, but the association with physical activity differs by gender.

  2. [Factor structure validity of the social capital scale used at baseline in the ELSA-Brasil study].

    PubMed

    Souto, Ester Paiva; Vasconcelos, Ana Glória Godoi; Chor, Dora; Reichenheim, Michael E; Griep, Rosane Härter

    2016-07-21

    This study aims to analyze the factor structure of the Brazilian version of the Resource Generator (RG) scale, using baseline data from the Brazilian Longitudinal Health Study in Adults (ELSA-Brasil). Cross-validation was performed in three random subsamples. Exploratory factor analysis using exploratory structural equation models was conducted in the first two subsamples to diagnose the factor structure, and confirmatory factor analysis was used in the third to corroborate the model defined by the exploratory analyses. Based on the 31 initial items, the model with the best fit included 25 items distributed across three dimensions. They all presented satisfactory convergent validity (values greater than 0.50 for the extracted variance) and precision (values greater than 0.70 for compound reliability). All factor correlations were below 0.85, indicating full discriminative factor validity. The RG scale presents acceptable psychometric properties and can be used in populations with similar characteristics.

  3. Subjective social status, self-rated health and tobacco smoking: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Camelo, Lidyane do V; Giatti, Luana; Barreto, Sandhi M

    2014-11-01

    Using baseline data from ELSA-Brasil (N = 15,105), we investigated whether subjective social status, measured using three 10-rung "ladders," is associated with self-rated health and smoking, independently of objective indicators of social position and depression symptoms. Additionally, we explored whether the magnitude of these associations varies according to the reference group. Subjective social status was independently associated with poor self-rated health and weakly associated with former smoking. The references used for social comparison did not change these associations significantly. Subjective social status, education, and income represent distinct aspects of social inequities, and the impact of each of these indicators on health is different. © The Author(s) 2013.

  4. Carotid intima-media thickness value distributions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Santos, Itamar S; Bittencourt, Márcio S; Oliveira, Ilka R S; Souza, Angelita G; Meireles, Danilo P; Rundek, Tatjana; Foppa, Murilo; Bezerra, Daniel C; Freire, Cláudia M V; Roelke, Leonard H; Carrilho, Sayonara; Benseñor, Isabela M; Lotufo, Paulo A

    2014-11-01

    Carotid intima-media thickness (IMT) is a noninvasive measurement of early atherosclerosis. Most IMT studies have involved populations with low rates of racial blending. The aim of the present article is to describe IMT value distributions and analyze the influence of sex and race on IMT values in a large Brazilian sample, a setting with a high rate of racial admixture. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a multicenter cohort of 15,105 adult (aged 35-74 years) civil servants in six Brazilian cities. Baseline assessment included IMT measurements in both common carotid arteries. Race was self-reported. We studied the association between sex and race with IMT values using multiple linear regression models. We conducted analyses in all and low-risk individuals, defined as those without classical cardiovascular risk factors. We analyzed complete IMT data from 10,405 ELSA-Brasil participants. We present nomograms by age for all and low-risk individuals, stratified by sex and race. We found that men had significantly higher maximal IMT values compared with women (β = 0.058; P < 0.001). This association remained for low-risk individuals (β = 0.027; P = 0.001). In addition, Brown and White individuals had lower maximal IMT values compared with Black individuals for all (β = -0.034 and β = -0.054, respectively; P < 0.001) and low-risk individuals (β = -0.027; P = 0.013 and β = -0.035; P < 0.001, respectively). We found significantly higher IMT values in men. We found significantly higher IMT values in Black individuals than White and Brown individuals. These results persisted when analyses were restricted to low-risk individuals. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  5. Comparison of machine-learning algorithms to build a predictive model for detecting undiagnosed diabetes - ELSA-Brasil: accuracy study.

    PubMed

    Olivera, André Rodrigues; Roesler, Valter; Iochpe, Cirano; Schmidt, Maria Inês; Vigo, Álvaro; Barreto, Sandhi Maria; Duncan, Bruce Bartholow

    2017-01-01

    Type 2 diabetes is a chronic disease associated with a wide range of serious health complications that have a major impact on overall health. The aims here were to develop and validate predictive models for detecting undiagnosed diabetes using data from the Longitudinal Study of Adult Health (ELSA-Brasil) and to compare the performance of different machine-learning algorithms in this task. Comparison of machine-learning algorithms to develop predictive models using data from ELSA-Brasil. After selecting a subset of 27 candidate variables from the literature, models were built and validated in four sequential steps: (i) parameter tuning with tenfold cross-validation, repeated three times; (ii) automatic variable selection using forward selection, a wrapper strategy with four different machine-learning algorithms and tenfold cross-validation (repeated three times), to evaluate each subset of variables; (iii) error estimation of model parameters with tenfold cross-validation, repeated ten times; and (iv) generalization testing on an independent dataset. The models were created with the following machine-learning algorithms: logistic regression, artificial neural network, naïve Bayes, K-nearest neighbor and random forest. The best models were created using artificial neural networks and logistic regression. -These achieved mean areas under the curve of, respectively, 75.24% and 74.98% in the error estimation step and 74.17% and 74.41% in the generalization testing step. Most of the predictive models produced similar results, and demonstrated the feasibility of identifying individuals with highest probability of having undiagnosed diabetes, through easily-obtained clinical data.

  6. Job stress is associated with migraine in current workers: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Santos, I S; Griep, R H; Alves, M G M; Goulart, A C; Lotufo, P A; Barreto, S M; Chor, D; Benseñor, I M

    2014-10-01

    Migraine is an important source of social burden and work-related costs. Studies addressing the association of migraine with job stress are rare. The aim of this paper was to study the association of job stress components and migraine using structured, validated questionnaires that were part of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The ELSA-Brasil is a multicentre cohort of 15,105 civil servants (12,096 current workers) in Brazil. Job strain was assessed using the 17-item Brazilian version of the Swedish Demand-Control-Support Questionnaire. Headache episodes in the preceding 12 months were assessed using a questionnaire based on the International Headache Society criteria. We analysed the association between job stress domains and migraine in men and women using adjusted logistic regression and interaction models. We included 3113 individuals without headache and 3259 migraineurs. Low job control [odds ratio (OR) 1.30; 95% confidence interval (95% CI) 1.10-1.53], high job demands (OR 1.37; 95% CI 1.18-1.59) and low social support (OR 1.49; 95% CI 1.29-1.71) were associated with migraine. Job control was more strongly associated with migraine in women (p for interaction = 0.02). High-strain (high demand and low control) jobs were associated with migraine in both men (OR 1.48; 95% CI 1.11-1.97) and women (OR 1.51; 95% CI 1.17-1.95). We observed a strong association between high-strain jobs and migraine. Job control was a stronger migraine-related factor for women. Low social support was associated with migraine in both sexes. © 2014 European Pain Federation - EFIC®

  7. Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL).

    PubMed

    Maluf, Chams B; Barreto, Sandhi M; Vidigal, Pedro G

    2015-01-01

    Platelet volume indices (PVI) are associated with hematological and non-hematological diseases, notably cardiovascular and cerebrovascular diseases. The establishment of PVI reference intervals (RIs) are essential to evaluate whether these indices are useful in clinical practice. Healthy-associated RIs have not yet been established for the Brazilian population. Here, we determined RIs of PVI for a health adult population, participants of the Brazilian Longitudinal Study of Adult Health ELSA-Brasil. A total of 580 individuals out of an initial sample of 3115 subjects constituted the healthy reference sample. To be part of the study, individuals had to fulfill the following criteria: blood count within 2 hours of collection, no use of continuous medication, self-rated health as good or very good, no reported diagnosis of diabetes and/or arterial hypertension, not smoking, lack of metabolic syndrome, body mass index (BMI) <30 kg/m(2), and platelet, hemoglobin, and creatinine beyond reference values. The RIs are mean platelet volume (MPV): 8.9-11.8 fL, platelet distribution width (PDW): 9.6-15.3 fL, platelet large cell ratio (P-LCR): 15.6-39.5%. These parameters were not significantly affected by age, gender, smoking, obesity, and alcohol abuse. However, significant differences were found among self-rated race/color groups. Standardization of measurement procedures and the establishment of healthy-associated PVI RIs are essential to be able to support clinical decision-making from laboratorial test results. This study at the baseline of the ELSA Brasil reported herein may contribute to future efforts aiming to evaluate whether PVI values are associated with clinical conditions in the Brazilian population.

  8. Association Between Short-Term Systolic Blood Pressure Variability and Carotid Intima-Media Thickness in ELSA-Brasil Baseline.

    PubMed

    Ribeiro, Adèle H; Lotufo, Paulo A; Fujita, André; Goulart, Alessandra C; Chor, Dora; Mill, José G; Bensenor, Isabela M; Santos, Itamar S

    2017-10-01

    Blood pressure (BP) is associated with carotid intima-media thickness (CIMT), but few studies have explored the association between BP variability and CIMT. We aimed to investigate this association in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline. We analyzed data from 7,215 participants (56.0% women) without overt cardiovascular disease (CVD) or antihypertensive use. We included 10 BP readings in varying positions during a 6-hour visit. We defined BP variability as the SD of these readings. We performed a 2-step analysis. We first linearly regressed the CIMT values on main and all-order interaction effects of the variables age, sex, body mass index, race, diabetes diagnosis, dyslipidemia diagnosis, family history of premature CVD, smoking status, and ELSA-Brasil site, and calculated the residuals (residual CIMT). We used partial least square path analysis to investigate whether residual CIMT was associated with BP central tendency and BP variability. Systolic BP (SBP) variability was significantly associated with residual CIMT in models including the entire sample (path coefficient [PC]: 0.046; P < 0.001), and in women (PC: 0.046; P = 0.007) but not in men (PC: 0.037; P = 0.09). This loss of significance was probably due to the smaller subsample size, as PCs were not significantly different according to sex. We found a small but significant association between SBP variability and CIMT values. This was additive to the association between SBP central tendency and CIMT values, supporting a role for high short-term SBP variability in atherosclerosis.

  9. Time From Smoking Cessation and Inflammatory Markers: New Evidence From a Cross-Sectional Analysis of ELSA-Brasil.

    PubMed

    Peres, Flávia Soares; Barreto, Sandhi Maria; Camelo, Lidyane V; Ribeiro, Antonio Luiz P; Vidigal, Pedro Guatimosim; Duncan, Bruce Bartholow; Giatti, Luana

    2017-07-01

    The time for inflammatory markers of former smokers to revert to never smoker levels is still controversial, ranging from 5 to 20 years. We aimed to determine the time from smoking cessation for white blood cell (WBC) count and serum C-reactive protein (CRP) levels to return to those of never-smokers, after adjusting for confounding factors and for secondhand smoke (SHS) exposure among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cross-sectional analysis of baseline participants of ELSA-Brasil. We used linear regression analysis and generalized linear models with gamma distribution and logarithmic link function to estimate the association of WBC count and CRP levels with time from smoking cessation. The following confounding factors were considered: sex, age, education, SHS, alcohol consumption, leisure-time physical activity, BMI, total cholesterol/HDL ratio, hypertension, diabetes, cardiovascular disease, and chronic obstructive pulmonary disease (COPD). Results: After all adjustments, time from smoking cessation <10 years remained associated with higher WBC count (eg, time from smoking cessation ≥ 5 and <10 years: β: 167.92; 95%CI: 23.52 312.31), while only time from smoking cessation <1 year remained associated with higher arithmetic mean of CRP (AMR: 1.26, 95%CI: 1.03‒1.54). Levels of inflammatory markers were similar to those of never-smokers 1 year after smoking cessation for CRP and 10 years after for WBC. The results may add to the arsenal health professionals have to encourage their patients to quit smoking, as some harms from smoking appear to revert to never-smokers' level sooner than previously reported. Longitudinal studies should confirm our findings.

  10. Gender and psychosocial factors associated with healthy lifestyle in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort: a cross-sectional study.

    PubMed

    Patrão, Ana Luísa; Almeida, Maria da Conceição; Matos, Sheila Maria Alvim; Chor, Dora; Aquino, Estela M L

    2017-08-28

    It has been estimated that over 50% of the premature deaths occurring in Western countries can be attributed to causes rooted in lifestyle. In turn, leading a healthy lifestyle has also been associated with a wide range of psychosocial factors. Today, it is known that these differ among men and women. The present article aimed to identify, from a gender-based perspective, the psychosocial factors associated with healthy lifestyles in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort, the largest study concerning adult health conducted in Latin America to date. This cross-sectional study was conducted using ELSA-Brasil baseline data, collected between 2008 and 2010. Six Brazilian public higher education and research institutions. The ELSA-Brasil cohort consists of approximately 15 000 employees (8218 women and 6887 men), both currently working and retired. The lifestyle indicator was constructed by summing the scores attributed to four different behaviours. The women of the ELSA-Brasil cohort have healthier lifestyles than men. In women, strong associations were found between a healthy lifestyle and age 60 years or older, Asian race and university level of education or higher. In men, being 60 years or older, of Asian or Caucasian race, having a high-school equivalent level of education or higher, being retired, having a housekeeper, having a good or very good self-perception of health and being satisfied with body image were the psychosocial factors associated with leading a healthy lifestyle. The factors that influenced healthy lifestyles were found to differ among men and women, a fact that must be addressed when developing programmes designed to promote health. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. Van Gogh's Sunflowers

    ERIC Educational Resources Information Center

    Daddino, Michelle

    2010-01-01

    In this article, the author describes an art project wherein kindergarten students painted sunflowers. These beautiful and colorful sunflowers were inspired by the book "Camille and the Sunflowers" by Laurence Anholt, which does an amazing job of introducing young children to the art and life of Vincent van Gogh.

  12. Van Gogh's Sunflowers

    ERIC Educational Resources Information Center

    Daddino, Michelle

    2010-01-01

    In this article, the author describes an art project wherein kindergarten students painted sunflowers. These beautiful and colorful sunflowers were inspired by the book "Camille and the Sunflowers" by Laurence Anholt, which does an amazing job of introducing young children to the art and life of Vincent van Gogh.

  13. Segments of van Gogh.

    ERIC Educational Resources Information Center

    Mannlein, Sally

    2002-01-01

    Describes an art project that was used with first grade students in which they learn about Vincent van Gogh's style of painting. Explains that the children learn to create circles and straight lines and how to fill in with color. (CMK)

  14. Remembering Van Gogh.

    ERIC Educational Resources Information Center

    Freifeld, Susan

    1999-01-01

    Describes an activity in which fourth grade students created a three-dimensional representation of Vincent Van Gogh's room in Arles (France). Expounds that the students had to invent their own strategies for three-dimensional construction and two-dimensional embellishment. Provides directions for creating the room and bed. (CMK)

  15. Heath Van Essen

    EPA Pesticide Factsheets

    The EPA is providing notice of a proposed Administrative Penalty Assessment against Heath Van Essen, Respondent, an individual who owns or operates an animal feeding operation (“Facility”) that is located in Section 27 of Township 98 North, Range 47 West,

  16. Pythagoras Meets Van Hiele.

    ERIC Educational Resources Information Center

    Flores, Alfinio

    1993-01-01

    Develops the Pythagorean Theorem in the context of the Van Hiele levels by presenting activities appropriate for each level. Activities point to preparatory development (level 0), give 3 different versions of Euclid's proof (levels 1, 2, and 3), give some generalizations of the theorem (level 3), and explore the Pythagorean relationship in other…

  17. Pythagoras Meets Van Hiele.

    ERIC Educational Resources Information Center

    Flores, Alfinio

    1993-01-01

    Develops the Pythagorean Theorem in the context of the Van Hiele levels by presenting activities appropriate for each level. Activities point to preparatory development (level 0), give 3 different versions of Euclid's proof (levels 1, 2, and 3), give some generalizations of the theorem (level 3), and explore the Pythagorean relationship in other…

  18. Van Gogh from Space

    NASA Image and Video Library

    2017-09-27

    Van Gogh from Space - July 13th, 2005 Description: In the style of Van Gogh's painting "Starry Night," massive congregations of greenish phytoplankton swirl in the dark water around Gotland, a Swedish island in the Baltic Sea. Phytoplankton are microscopic marine plants that form the first link in nearly all ocean food chains. Population explosions, or blooms, of phytoplankton, like the one shown here, occur when deep currents bring nutrients up to sunlit surface waters, fueling the growth and reproduction of these tiny plants. Credit: USGS/NASA/Landsat 7 To learn more about the Landsat satellite go to: landsat.gsfc.nasa.gov/ NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

  19. Van Horn folio, Texas

    USGS Publications Warehouse

    Richardson, G.B.

    1914-01-01

    The Van Horn quadrangle is situated in EL Paso and Culberson counties, Tex., about 100 miles southeast of El Paso.  It is bounded by parallels 31° and 31° 30' and meridians 104° 30' and 105° and incluedes 1019 square miles.  This area lies within the Cordilleran region, about midway between Peco River and teh Rio Grande, and forms a part of what is known as trans-Pecos Texas.  

  20. [Van Helmont and gas].

    PubMed

    van Gijn, Jan; Gijselhart, Joost P

    2012-01-01

    Johan Baptista van Helmont (1579-1644) was born in Brussels, around the time the Southern Netherlands ceased their resistance against the Spanish rule. He studied a variety of disciplines in Louvain and made a 'grand tour' in Europe, but remained dissatisfied with traditional knowledge, which he regarded as empty phrases and sophistry. His spouse being wealthy, he devoted himself to studying nature anew, unencumbered by prejudice, as Paracelsus (1493-1541) had done before him. Yet in his attempts to explain living and inanimate matter he could not avoid making basic assumptions. Among these was his view that there were only two elements: water and air. Water might carry elementary seeds from which a variety of substances could develop. When a substance was consumed by fire, an ethereal essence would remain, which he called 'Gas' (a term perhaps derived from Paracelsian 'chaos', perhaps from 'Geist'). Today 'gas' is defined as the volatile state of a given substance, but in Van Helmont's view it was mainly a metaphysical characteristic. Most of Van Helmont's work was published only after his death, through a verdict of the Spanish Inquisition.

  1. Major Electrocardiographic Abnormalities According to the Minnesota Coding System Among Brazilian Adults (from the ELSA-Brasil Cohort Study).

    PubMed

    Pinto-Filho, Marcelo M; Brant, Luisa C C; Foppa, Murilo; Garcia-Silva, Kaiser B; Mendes de Oliveira, Rackel Aguiar; de Jesus Mendes da Fonseca, Maria; Alvim, Sheila; Lotufo, Paulo A; Mill, José G; Barreto, Sandhi M; Macfarlane, Peter W; Ribeiro, Antonio L P

    2017-06-15

    The electrocardiogram is a simple and useful clinical tool; nevertheless, few studies have evaluated the prevalence of electrocardiographic abnormalities in the Latin American population. This study aims to evaluate the major electrocardiographic abnormalities according to the Minnesota coding system in Brazilian adults, stratified by gender, age, race, and cardiovascular risk factors. Data from 14,424 adults (45.8% men, age 35 to 74 years) were obtained at baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), according to standardized protocol. The electrocardiogram were obtained with the Burdick Atria 6100 machine, stored on Pyramis System, automatically coded according to the Minnesota coding system by the Glasgow University software and then manually revised. Major abnormalities were more prevalent in men than women (11.3% and 7.9%, p <0.001). These differences were consistent through the different age groups, race, and number of cardiovascular risk factors. Electrocardiographic major abnormalities were more prevalent in black participants for both men (black: 15.1%, mixed: 10.4%, white: 11.1%, p = 0.001) and women (black: 10%, mixed: 7.6%, white: 7.2%, p = 0.004). In conclusion, in this large sample of Brazilian adults, the prevalence of major electrocardiographic abnormalities was higher among men, the elderly, black, and among people with more cardiovascular risk factors. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. van der Waals torque

    NASA Astrophysics Data System (ADS)

    Esquivel-Sirvent, Raul; Schatz, George

    2014-03-01

    The theory of generalized van der Waals forces by Lifshtz when applied to optically anisotropic media predicts the existence of a torque. In this work we present a theoretical calculation of the van der Waals torque for two systems. First we consider two isotropic parallel plates where the anisotropy is induced using an external magnetic field. The anisotropy will in turn induce a torque. As a case study we consider III-IV semiconductors such as InSb that can support magneto plasmons. The calculations of the torque are done in the Voigt configuration, that occurs when the magnetic field is parallel to the surface of the slabs. The change in the dielectric function as the magnetic field increases has the effect of decreasing the van der Waals force and increasing the torque. Thus, the external magnetic field is used to tune both the force and torque. The second example we present is the use of the torque in the non retarded regime to align arrays of nano particle slabs. The torque is calculated within Barash and Ginzburg formalism in the nonretarded limit, and is quantified by the introduction of a Hamaker torque constant. Calculations are conducted between anisotropic slabs of materials including BaTiO3 and arrays of Ag nano particles. Depending on the shape and arrangement of the Ag nano particles the effective dielectric function of the array can be tuned as to make it more or less anisotropic. We show how this torque can be used in self assembly of arrays of nano particles. ref. R. Esquivel-Sirvent, G. C. Schatz, Phys. Chem C, 117, 5492 (2013). partial support from DGAPA-UNAM.

  3. Use of the Method of Triads in the Validation of Sodium and Potassium Intake in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    Pereira, Taísa Sabrina Silva; Cade, Nágela Valadão; Mill, José Geraldo; Sichieri, Rosely; Molina, Maria del Carmen Bisi

    2016-01-01

    Introduction Biomarkers are a good choice to be used in the validation of food frequency questionnaire due to the independence of their random errors. Objective To assess the validity of the potassium and sodium intake estimated using the Food Frequency Questionnaire ELSA-Brasil. Subjects/Methods A subsample of participants in the ELSA-Brasil cohort was included in this study in 2009. Sodium and potassium intake were estimated using three methods: Semi-quantitative food frequency questionnaire, 12-hour nocturnal urinary excretion and three 24-hour food records. Correlation coefficients were calculated between the methods, and the validity coefficient was calculated using the method of triads. The 95% confidence intervals for the validity coefficient were estimated using bootstrap sampling. Exact and adjacent agreement and disagreement of the estimated sodium and potassium intake quintiles were compared among three methods. Results The sample consisted of 246 participants, aged 53±8 years, 52% of women. Validity coefficient for sodium were considered weak (рfood frequency questionnaire actual intake = 0.37 and рbiomarker actual intake = 0.21) and moderate (рfood records actual intake 0.56). The validity coefficient were higher for potassium (рfood frequency questionnaire actual intake = 0.60; рbiomarker actual intake = 0.42; рfood records actual intake = 0.79). Conclusions: The Food Frequency Questionnaire ELSA-Brasil showed good validity in estimating potassium intake in epidemiological studies. For sodium validity was weak, likely due to the non-quantification of the added salt to prepared food. PMID:28030625

  4. Use of the Method of Triads in the Validation of Sodium and Potassium Intake in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Pereira, Taísa Sabrina Silva; Cade, Nágela Valadão; Mill, José Geraldo; Sichieri, Rosely; Molina, Maria Del Carmen Bisi

    2016-01-01

    Biomarkers are a good choice to be used in the validation of food frequency questionnaire due to the independence of their random errors. To assess the validity of the potassium and sodium intake estimated using the Food Frequency Questionnaire ELSA-Brasil. A subsample of participants in the ELSA-Brasil cohort was included in this study in 2009. Sodium and potassium intake were estimated using three methods: Semi-quantitative food frequency questionnaire, 12-hour nocturnal urinary excretion and three 24-hour food records. Correlation coefficients were calculated between the methods, and the validity coefficient was calculated using the method of triads. The 95% confidence intervals for the validity coefficient were estimated using bootstrap sampling. Exact and adjacent agreement and disagreement of the estimated sodium and potassium intake quintiles were compared among three methods. The sample consisted of 246 participants, aged 53±8 years, 52% of women. Validity coefficient for sodium were considered weak (рfood frequency questionnaire actual intake = 0.37 and рbiomarker actual intake = 0.21) and moderate (рfood records actual intake 0.56). The validity coefficient were higher for potassium (рfood frequency questionnaire actual intake = 0.60; рbiomarker actual intake = 0.42; рfood records actual intake = 0.79). Conclusions: The Food Frequency Questionnaire ELSA-Brasil showed good validity in estimating potassium intake in epidemiological studies. For sodium validity was weak, likely due to the non-quantification of the added salt to prepared food.

  5. Van Gogh syndrome.

    PubMed

    Roka, Y B; Thapa, R; Puri, P R; Aryal, S

    2011-04-01

    Self injury is the intentional and direct injury to self that include bite, burn, ulceration and head banging. These injuries are rarely fatal and are usually not suicidal in nature. This behavior is common among adolescents, psychiatric patients and in females. Bipolar disorder, drug abuse and metabolic syndromes like LeschNyhan and Munchausen's syndrome are often associated with this disorder. Repetitive self mutilation is termed the Van Gogh syndrome after the famous painter who cut off his ear and gave it to a prostitute. We describe two such cases of self mutilation in schizophrenic patients.

  6. Defending commercial surrogate motherhood against Van Niekerk and Van Zyl.

    PubMed

    McLachlan, H V

    1997-12-01

    The arguments of Van Niekerk and Van Zyl that, on the grounds that it involves an inappropriate commodification and alienation of women's labour, commercial surrogate motherhood (CSM) is morally suspect are discussed and considered to be defective. In addition, doubt is cast on the notion that CSM should be illegal.

  7. First Measurement of the Gerasimov-Drell-Hearn Sum Rule for 1H from 0.7 to 1.8GeV at ELSA

    NASA Astrophysics Data System (ADS)

    Dutz, H.; Helbing, K.; Krimmer, J.; Speckner, T.; Zeitler, G.; Ahrens, J.; Altieri, S.; Annand, J. R.; Anton, G.; Arends, H.-J.; Beck, R.; Bock, A.; Bradtke, C.; Braghieri, A.; v. Drachenfels, W.; Frommberger, F.; Godo, M.; Goertz, S.; Grabmayr, P.; Hasegawa, S.; Hansen, K.; Harmsen, J.; Heid, E.; Hillert, W.; Holvoet, H.; Horikawa, N.; Iwata, T.; Hoorebeke, L. Van; D'Hose, N.; Jennewein, P.; Kiel, B.; Klein, F.; Kondratiev, R.; Lang, M.; Lannoy, B.; Leukel, R.; Lisin, V.; Menze, D.; Meyer, W.; Michel, T.; Naumann, J.; Panzeri, A.; Pedroni, P.; Pinelli, T.; Preobrajenski, I.; Radtke, E.; Reicherz, G.; Rohlof, C.; Rostomyan, T.; Sauer, M.; Schoch, B.; Schumacher, M.; Tamas, G.; Thomas, A.; van de Vyver, R.; Weihofen, W.; Zapadtka, F.

    2003-11-01

    To verify the fundamental Gerasimov-Drell-Hearn (GDH) sum rule for the first time experimentally, we measured the helicity dependent total photoabsorption cross section with circularly polarized real photons and longitudinally polarized nucleons in the photon energy range 0.68 1.82GeV with the tagged photon facility at ELSA. The experiment was carried out with a 4π detection system, a circularly polarized tagged photon beam, and a frozen spin polarized proton target. The contribution to the GDH sum rule in this photon energy range is [49.9±2.4(stat)±2.2(syst)] μb.

  8. The ELSA - Flood - Stack: A reconstruction from the laminated sediments of Eifel Maar structures during the last 60 000 years

    NASA Astrophysics Data System (ADS)

    Brunck, Heiko; Sirocko, Frank; Albert, Johannes

    2016-04-01

    events from 60 000 years until present times and indicates variable periodicities of flood activity linked to predominant climatic and anthropogenic development. It turns out that low vegetation coverage related to Greenland Stadial phases or anthropogenic impact is the main cause for the development of flood layers in maar sediments, while precipitation plays only a secondary role. References Brunck, H., Albert, J., Sirocko, F., 2015 (in press). The ELSA - Flood - Stack: A reconstruction from the laminated sediments of Eifel Maar structures during the last 60 000 years. Global and Planetary Change, Elsevier. Sirocko, F., Knapp, H., Dreher, F., Förster, M., Albert, J., Brunck, H., Veres, D., Dietrich, S., Zech, M., Hambach, U., Röhner, M., Rudert, S., Schwibus, K., Adams, C., Sigl, P., 2015 (in press). The ELSA-Vegetation-Stack: Reconstruction of Landscape Evolution Zones (LEZ) from laminated Eifel maar sediments of the last 60 000 years. Global and Planetary Change, Elsevier.

  9. Epicardial fat thickness: distribution and association with diabetes mellitus, hypertension and the metabolic syndrome in the ELSA-Brasil study.

    PubMed

    Graeff, Daniela Bertol; Foppa, Murilo; Pires, Julio Cesar Gall; Vigo, Alvaro; Schmidt, Maria Ines; Lotufo, Paulo Andrade; Mill, Jose Geraldo; Duncan, Bruce Bartholow

    2016-04-01

    Epicardial fat thickness (EFT) has emerged as a marker of cardiometabolic risk, but its clinical use warrants proper knowledge of its distribution and associations in populations. We aimed to describe the distribution of EFT, its demographic correlates and independent associations with diabetes, hypertension and metabolic syndrome (MS) in free-living Brazilian adults. From the baseline echocardiography of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)-a cohort study of civil servants aged 35-74 years-EFT was measured from a randomly selected sample of 998 participants as the mean of two paraesternal windows obtained at end systole (EFTsyst) and end diastole (EFTdiast). From the 421 individuals free of diabetes, hypertension and MS, we defined EFT reference values and the EFTsyst 75th percentile cut-off. Median EFTsyst was 1.5 (IQR 0-2.6) mm; a large proportion (84 %) had EFTdiast = 0. EFT was higher in women and lower in blacks, and increased with age and BMI. Although EFT was higher in those with diabetes, hypertension, and MS, EFT associations were reduced when adjusted for age, sex and ethnicity, and were non-significant after adjusting for obesity measures. In conclusion, the amount of EFT in this large multiethnic population is smaller than reported in other populations. EFT reference values varied across demographic and clinical variables, EFT associations with cardiometabolic variables being largely explained by age, sex, ethnicity and central obesity. Although EFT can help identify individuals at increased cardiometabolic risk, it will likely have a limited additional role compared to current risk stratification strategies.

  10. Factors associated with metabolically healthy status in obesity, overweight, and normal weight at baseline of ELSA-Brasil.

    PubMed

    Diniz, Maria de Fátima Haueisen Sander; Beleigoli, Alline Maria Rezende; Ribeiro, Antônio Luiz P; Vidigal, Pedro Guatimosim; Bensenor, Isabela M; Lotufo, Paulo A; Duncan, Bruce B; Schmidt, Maria Inês; Barreto, Sandhi Maria

    2016-07-01

    The primary aim of this study was to evaluate metabolically healthy status (MHS) among participants in obesity, overweight, and normal weight groups and characteristics associated with this phenotype using baseline data of Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The secondary aim was to investigate agreement among 4 different MHS criteria. This cross-sectional study included 14,545 participants aged 35 to 74 years with a small majority (54.1%) being women. Of all participants, 22.7% (n = 3298) were obese, 40.8% (n = 5934) were overweight, and 37.5% (n = 5313) were of normal weight.Socio-demographic, behavioral, and anthropometric factors related to MHS were ascertained. Logistic regression models estimated the odds of associations. We used 4 different criteria separately and in combination to define MHS: the National Health and Nutrition Examination Survey (NHANES), the National Cholesterol Education Program (NCEP-ATPIII), the International Diabetes Federation (IDF) and comorbidities, and the agreement between them were evaluated by Cohen-kappa coefficient.MHS was present among 12.0% (n = 396) of obese, 25.5% (n = 1514) of overweight, and 48.6% (n = 2582) of normal weight participants according to the combination of the 4 criteria. The agreement between all the 4 MHS criteria was strong (kappa 0.73 P < 0.001). In final logistic models, MHS was associated with lower age, female sex, lower body mass index (BMI), and weight change from age 20 within all BMI categories.This study showed that, despite differences in prevalence among the 4 criteria, MHS was associated with common characteristics at every BMI category.

  11. Investigating the Bidirectional Associations of Adiposity with Sleep Duration in Older Adults: The English Longitudinal Study of Ageing (ELSA)

    PubMed Central

    Garfield, Victoria; Llewellyn, Clare H.; Steptoe, Andrew; Kumari, Meena

    2017-01-01

    Cross-sectional analyses of adiposity and sleep duration in younger adults suggest that increased adiposity is associated with shorter sleep. Prospective studies have yielded mixed findings, and the direction of this association in older adults is unclear. We examined the cross-sectional and potential bi-directional, prospective associations between adiposity and sleep duration (covariates included demographics, health behaviours, and health problems) in 5,015 respondents from the English Longitudinal Study of Ageing (ELSA), at baseline and follow-up. Following adjustment for covariates, we observed no significant cross-sectional relationship between body mass index (BMI) and sleep duration [(unstandardized) B = −0.28 minutes, (95% Confidence Intervals (CI) = −0.012; 0.002), p = 0.190], or waist circumference (WC) and sleep duration [(unstandardized) B = −0.10 minutes, (95% CI = −0.004; 0.001), p = 0.270]. Prospectively, both baseline BMI [B = −0.42 minutes, (95% CI = −0.013; −0.002), p = 0.013] and WC [B = −0.18 minutes, (95% CI = −0.005; −0.000), p = 0.016] were associated with decreased sleep duration at follow-up, independently of covariates. There was, however, no association between baseline sleep duration and change in BMI or WC (p > 0.05). In older adults, our findings suggested that greater adiposity is associated with decreases in sleep duration over time; however the effect was very small. PMID:28067295

  12. Factors associated with metabolically healthy status in obesity, overweight, and normal weight at baseline of ELSA-Brasil

    PubMed Central

    Diniz, Maria de Fátima Haueisen Sander; Beleigoli, Alline Maria Rezende; Ribeiro, Antônio Luiz P.; Vidigal, Pedro Guatimosim; Bensenor, Isabela M.; Lotufo, Paulo A.; Duncan, Bruce B.; Schmidt, Maria Inês; Barreto, Sandhi Maria

    2016-01-01

    Abstract The primary aim of this study was to evaluate metabolically healthy status (MHS) among participants in obesity, overweight, and normal weight groups and characteristics associated with this phenotype using baseline data of Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The secondary aim was to investigate agreement among 4 different MHS criteria. This cross-sectional study included 14,545 participants aged 35 to 74 years with a small majority (54.1%) being women. Of all participants, 22.7% (n = 3298) were obese, 40.8% (n = 5934) were overweight, and 37.5% (n = 5313) were of normal weight. Socio-demographic, behavioral, and anthropometric factors related to MHS were ascertained. Logistic regression models estimated the odds of associations. We used 4 different criteria separately and in combination to define MHS: the National Health and Nutrition Examination Survey (NHANES), the National Cholesterol Education Program (NCEP-ATPIII), the International Diabetes Federation (IDF) and comorbidities, and the agreement between them were evaluated by Cohen-kappa coefficient. MHS was present among 12.0% (n = 396) of obese, 25.5% (n = 1514) of overweight, and 48.6% (n = 2582) of normal weight participants according to the combination of the 4 criteria. The agreement between all the 4 MHS criteria was strong (kappa 0.73 P < 0.001). In final logistic models, MHS was associated with lower age, female sex, lower body mass index (BMI), and weight change from age 20 within all BMI categories. This study showed that, despite differences in prevalence among the 4 criteria, MHS was associated with common characteristics at every BMI category. PMID:27399079

  13. Coffee Consumption and Heart Rate Variability: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Cohort Study.

    PubMed

    de Oliveira, Rackel Aguiar Mendes; Araújo, Larissa Fortunato; de Figueiredo, Roberta Carvalho; Goulart, Alessandra C; Schmidt, Maria Ines; Barreto, Sandhi Maria; Ribeiro, Antonio Luiz Pinho

    2017-07-13

    Studies have shown that acute coffee ingestion can affect cardiovascular autonomic activity, although the chronic effects on heart rate variability (HRV) remain controversial. A cross-sectional study with baseline data (2008-2010) from ELSA-Brasil cohort of 15,105 (aged 35-74), based in six Brazilian states. Coffee consumption in the previous 12 months was measured using the semi-quantitative food frequency questionnaire, and HRV was obtained through electrocardiographic tracings during 10 min at rest. Independent association between the frequency of coffee consumption "never or almost never", "≤1 cup/day", "2-3 cups/day", "≥3 cups/day", and HRV was estimated using generalized linear regression, adjusting for socio-demographic characteristics, health-related behavior, markers of abnormal metabolism, and the presence of coronary artery disease. Further, we applied Bonferroni correction in the full models. The mean age was 52 years (standard deviation (SD) = 9.1), and 52% was female; 9.5% never/almost never consumed coffee. In univariate analysis, coffee consumers had reduced values of HRV indexes, but after full adjustments and correction for multiple comparisons, these associations disappeared. A trend of reduction in HRV vagal indexes was observed in those that consumed ≥3 cups of coffee/day. Most of the effects attributed to the chronic use of coffee on the HRV indexes is related to the higher prevalence of unhealthy habits in coffee users, such as smoking and alcohol use. Adjustment for confounding factors weaken this association, making it non-significant. The effect of higher daily doses of coffee on the autonomic system should be evaluated in further studies.

  14. Job strain and binge eating among Brazilian workers participating in the ELSA-Brasil study: does BMI matter?

    PubMed

    Pena Gralle, Ana Paula Bruno; Barbosa Moreno, Arlinda; Lopes Juvanhol, Leidjaira; Mendes da Fonseca, Maria de Jesus; Prates Melo, Enirtes Caetano; Antunes Nunes, Maria Angélica; Toivanen, Susanna; Griep, Rosane Härter

    2017-05-25

    To assess the association between job strain and binge eating as well as the effect-modifying influence of body mass index (BMI) on this association. A total of 11,951 active civil servants from the multicenter Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) was included in this cross-sectional analysis. Job strain was assessed using the Demand-Control-Support Questionnaire. Binge eating was defined as eating a large amount of food with a sense of lack of control over what and how much is eaten in less than 2 hours at least twice a week. Multiple logistic regression was used to determine the association between binge eating and job strain as well as its interaction with BMI. After adjustment, and using low-strain job as the reference category, binge eating was associated with high-strain job (high demand/low control: odds ratio [OR]=1.58, 95% confidence interval [CI] 1.26-1.98), active job (high demand/high control: OR=1.35, 95% CI 1.07-1.70), and passive job (low demand/low control: OR=1.24, 95% CI 1.01-1.53). Psychological job demands were positively associated with binge eating (OR=1.04, 95% CI 1.01-1.07), while greater job control and social support at work were each inversely associated with binge eating (OR=0.95, 95% CI 0.92-0.97 and OR=0.96, 95% CI 0.94-0.98, respectively). BMI modified the association between job strain and binge eating: Heavier psychological job demands were associated with higher odds of binge eating among obese participants, while a stronger inverse association between job control and binge eating was seen among slimmer participants. Job strain increases the odds of binge eating and this association is modified by BMI.

  15. Data Resource Profile: Cross-national and cross-study sociodemographic and health-related harmonized domains from SAGE plus ELSA, HRS and SHARE (SAGE+, Wave 1).

    PubMed

    Minicuci, Nadia; Naidoo, Nirmala; Chatterji, Somnath; Kowal, Paul

    2016-10-01

    Four longitudinal studies were included in this rigorous harmonization process: the Study on global AGEing and adult health (SAGE); English Longitudinal Study on Ageing (ELSA); US Health and Retirement Study (HRS); and Survey of Health, Ageing and Retirement in Europe (SHARE). An ex-post harmonized process was applied to nine health-related thematic domains (socio-demographic and economic, health states, overall self-report of health and mental state, health examinations, physical and mental performance tests, risk factors, chronic conditions, social network and subjective well-being) for data from the 2004 wave of each study. Large samples of adults aged 50 years and older were available from each study: SAGE, n = 18 886; ELSA, n = 9181; HRS, n = 19 303; and SHARE, n = 29 917. The microdata, along with further details about the harmonization process and all metadata, are available through the World Health Organization (WHO) data archive at [http://apps.who.int/healthinfo/systems/surveydata/index.php/catalog]. Further information and enquiries can be made to [sagesurvey@who.int] or the corresponding author. The data resource will continue to be updated with data across additional waves of these surveys and new waves.

  16. Data Resource Profile: Cross-national and cross-study sociodemographic and health-related harmonized domains from SAGE plus ELSA, HRS and SHARE (SAGE+, Wave 1)

    PubMed Central

    Minicuci, Nadia; Naidoo, Nirmala; Chatterji, Somnath; Kowal, Paul

    2016-01-01

    Four longitudinal studies were included in this rigorous harmonization process: the Study on global AGEing and adult health (SAGE); English Longitudinal Study on Ageing (ELSA); US Health and Retirement Study (HRS); and Survey of Health, Ageing and Retirement in Europe (SHARE). An ex-post harmonized process was applied to nine health-related thematic domains (socio-demographic and economic, health states, overall self-report of health and mental state, health examinations, physical and mental performance tests, risk factors, chronic conditions, social network and subjective well-being) for data from the 2004 wave of each study. Large samples of adults aged 50 years and older were available from each study: SAGE, n = 18 886; ELSA, n = 9181; HRS, n = 19 303; and SHARE, n = 29 917. The microdata, along with further details about the harmonization process and all metadata, are available through the World Health Organization (WHO) data archive at [http://apps.who.int/healthinfo/systems/surveydata/index.php/catalog]. Further information and enquiries can be made to [sagesurvey@who.int] or the corresponding author. The data resource will continue to be updated with data across additional waves of these surveys and new waves. PMID:27794522

  17. Gender aspects of the relationship between migraine and cardiovascular risk factors: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Goulart, Alessandra C; Santos, Itamar S; Lotufo, Paulo A; Benseñor, Isabela M

    2015-10-01

    The relationship between cardiovascular risk factors (CVRF) and migraine is controversial and might be different in both genders. These associations were evaluated in Brazilian middle-aged men and women from the Longitudinal Study of Adult Health (ELSA-Brasil). The cross-sectional relationship between our main outcome, which was migraine headache (definite, probable and overall), and CVRF was evaluated in the total sample and according to gender. We calculated frequencies and odds ratios (95% CI) for this relationship using binary and multinomial logistic regression analyses in crude, age-adjusted and multivariable models adjusted by potential confounders. Of 14,953 individuals who completed the data about headache and CVRF, the frequency of one-year migraine was of 29.5% (22.5% in women and 7.0% in men). In the multivariable-adjusted regression analyses, an inverse association between hypertension (OR, 0.53; 95% CI, 0.36-0.79), metabolic syndrome (OR, 0.65; 95% CI, 0.43-0.99) and definite migraine were confirmed for men, but not for women. In the opposite direction, a positive association between migraine headaches (definite, probable and overall) and dyslipidemia (overall migraine OR, 1.25; 95% CI, 1.13-1.38) was observed only for women, but not for men. A gender influence on the relationship between migraine and CVRF was verified in the ELSA-Brasil. © International Headache Society 2015.

  18. Diabetes mellitus and sensorineural hearing loss: is there an association? Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Samelli, Alessandra G; Santos, Itamar S; Moreira, Renata R; Rabelo, Camila M; Rolim, Laurie P; Bensenõr, Isabela J; Lotufo, Paulo A

    2017-01-01

    Although several studies have investigated the effects of diabetes on hearing loss, the relationship between these two conditions remains unclear. Some studies have suggested that diabetes may cause sensorineural hearing loss, whereas others have failed to find an association. The biggest challenge in investigating the association between diabetes and hearing loss is the presence of confounding variables and the complexity of the auditory system. Our study investigated the association between diabetes and sensorineural hearing loss. We evaluated the influence of time from diabetes diagnosis on this association after controlling for age, gender, and hypertension diagnosis and excluding those subjects with exposure to noise. This cross-sectional study evaluated 901 adult and elderly Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) participants from São Paulo, Brazil who underwent audiometry testing as part of ELSA-Brasil's baseline assessment. Hearing thresholds and speech test results were significantly worse in the group with diabetes than in the group without diabetes. However, no significant differences were found between participants with and without diabetes after adjusting for age, gender, and the presence of hypertension. Hearing thresholds were not affected by occupational noise exposure in the groups with and without diabetes. In addition, no association between the duration of diabetes and hearing thresholds was observed after adjusting for age, gender, and hypertension. We found no association between the duration of diabetes and worse hearing thresholds after models were adjusted for age, gender, and the presence of hypertension.

  19. Diabetes mellitus and sensorineural hearing loss: is there an association? Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    Samelli, Alessandra G; Santos, Itamar S; Moreira, Renata R; Rabelo, Camila M; Rolim, Laurie P; Bensenõr, Isabela J; Lotufo, Paulo A

    2017-01-01

    OBJECTIVES: Although several studies have investigated the effects of diabetes on hearing loss, the relationship between these two conditions remains unclear. Some studies have suggested that diabetes may cause sensorineural hearing loss, whereas others have failed to find an association. The biggest challenge in investigating the association between diabetes and hearing loss is the presence of confounding variables and the complexity of the auditory system. Our study investigated the association between diabetes and sensorineural hearing loss. We evaluated the influence of time from diabetes diagnosis on this association after controlling for age, gender, and hypertension diagnosis and excluding those subjects with exposure to noise. METHODS: This cross-sectional study evaluated 901 adult and elderly Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) participants from São Paulo, Brazil who underwent audiometry testing as part of ELSA-Brasil’s baseline assessment. RESULTS: Hearing thresholds and speech test results were significantly worse in the group with diabetes than in the group without diabetes. However, no significant differences were found between participants with and without diabetes after adjusting for age, gender, and the presence of hypertension. Hearing thresholds were not affected by occupational noise exposure in the groups with and without diabetes. In addition, no association between the duration of diabetes and hearing thresholds was observed after adjusting for age, gender, and hypertension. CONCLUSION: We found no association between the duration of diabetes and worse hearing thresholds after models were adjusted for age, gender, and the presence of hypertension. PMID:28226026

  20. Imaging van der Waals Interactions.

    PubMed

    Han, Zhumin; Wei, Xinyuan; Xu, Chen; Chiang, Chi-Lun; Zhang, Yanxing; Wu, Ruqian; Ho, W

    2016-12-15

    The van der Waals interactions are responsible for a large diversity of structures and functions in chemistry, biology, and materials. Discussion of van der Waals interactions has focused on the attractive potential energy that varies as the inverse power of the distance between the two interacting partners. The origin of the attractive force is widely discussed as being due to the correlated fluctuations of electron charges that lead to instantaneous dipole-induced dipole attractions. Here, we use the inelastic tunneling probe to image the potential energy surface associated with the van der Waals interactions of xenon atoms.

  1. Stirling Powered Van Progam overview

    NASA Technical Reports Server (NTRS)

    Shaltens, R. K.

    1986-01-01

    The Stirling Powered Van Program (SPVP) is a multiyear, multiphase program to evaluate the automotive Stirling engine (ASE) in Air Force vans under realistic conditions. The objective of the SPVP is to transfer to manufacturer and end user(s) (i.e., on the path to commercialization) the second-generation Mod 2 ASE upon completion of the Automotive Stirling Engine Program in 1987. In order to meet this objective, the SPVP must establish Stirling performance, integrity, reliability, durability and maintainability. The ASE program background leading to the van program is reviewed and plans for evaluating the kinematic Stirling engine in Air Force vans examined. Also discussed are the NASA technology transfers to industry that have been accomplished and those which are currently being developed.

  2. Ellis-van Creveld syndrome

    MedlinePlus

    Chondroectodermal dysplasia; EVC ... 1 of 2 Ellis-van Creveld syndrome genes ( EVC and EVC2 ). These genes are positioned next to ... performed for mutations in 1 of the 2 EVC genes Skeletal x-ray Ultrasound Urinalysis

  3. Van der Waals quintessence stars

    SciTech Connect

    Lobo, Francisco S. N.

    2007-01-15

    The van der Waals quintessence equation of state is an interesting scenario for describing the late universe, and seems to provide a solution to the puzzle of dark energy, without the presence of exotic fluids or modifications of the Friedmann equations. In this work, the construction of inhomogeneous compact spheres supported by a van der Waals equation of state is explored. These relativistic stellar configurations shall be denoted as van der Waals quintessence stars. Despite of the fact that, in a cosmological context, the van der Waals fluid is considered homogeneous, inhomogeneities may arise through gravitational instabilities. Thus, these solutions may possibly originate from density fluctuations in the cosmological background. Two specific classes of solutions, namely, gravastars and traversable wormholes are analyzed. Exact solutions are found, and their respective characteristics and physical properties are further explored.

  4. Stirling Powered Van Program overview

    SciTech Connect

    Shaltens, R.K.

    1986-01-01

    The Stirling Powered Van Program (SPVP) is a multiyear, multiphase program to evaluate the automotive Stirling engine (ASE) in Air Force vans under realistic conditions. The objective of the SPVP is to have a manufacturer and end user(s) (i.e., on the path to commercialization) of the second-generation Mod II ASE upon completion of the Automotive Stirling Engine Program in 1987. In order to meet this objective, the SPVP must establish Stirling performance, integrity, reliability, durability, and maintainability. This paper reviews the ASE Program background leading to the Van Program and focuses on plans for evaluating the kinematic Stirling engine in Air Force vans. Also discussed are the NASA technology transfers to industry that have been accomplished and those which are currently being developed.

  5. Stirling Powered Van Program overview

    SciTech Connect

    Shaltens, R.K.

    1986-01-01

    The Stirling Powered Van Program (SPVP) is a multiyear, multiphase program to evaluate the automotive Stirling engine (ASE) in Air Force vans under realistic conditions. The objective of the SPVP is to have a manufacturer and end user(s) (i.e., on the path to commercialization) of the second-generation Mod II ASE upon completion of the Automotive Stirling Engine Program in 1987. In order to meet this objective, the SPVP must establish Stirling performance, integrity, reliability, durability, and maintainability. This paper reviews the ASE Program background leading to the Van Program and focuses on plans for evaluating the kinematic Stirling engine in Air Force vans. Also discussed are the NASA technology transfers to industry that have been accomplished and those which are currently being developed. 14 refs.

  6. Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health).

    PubMed

    Kianoush, Sina; Yakoob, Mohammad Yawar; Al-Rifai, Mahmoud; DeFilippis, Andrew P; Bittencourt, Marcio S; Duncan, Bruce B; Bensenor, Isabela M; Bhatnagar, Aruni; Lotufo, Paulo A; Blaha, Michael J

    2017-06-24

    There is a need to identify sensitive biomarkers of early tobacco-related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. We studied 14 103 participants without clinical cardiovascular disease in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross-sectional associations between smoking parameters and inflammation (high-sensitivity C-reactive protein [hsCRP]) and measures of subclinical atherosclerosis (carotid intima-media thickness, ankle-brachial index, and coronary artery calcium [CAC]). The cohort included 1844 current smokers, 4121 former smokers, and 8138 never smokers. Mean age was 51.7±8.9 years; 44.8% were male. After multivariable adjustment, compared with never smokers, current smokers had significantly higher levels of hsCRP (β=0.24, 0.19-0.29 mg/L; P<0.001) and carotid intima-media thickness (β=0.03, 0.02-0.04 mm; P<0.001) and odds of ankle-brachial index ≤1.0 (odds ratio: 2.52; 95% confidence interval, 2.06-3.08; P<0.001) and CAC >0 (odds ratio: 1.83; 95% confidence interval, 1.46-2.30; P<0.001). Among former and current smokers, pack-years of smoking (burden) were significantly associated with hsCRP (P<0.001 and P=0.006, respectively) and CAC (P<0.001 and P=0.002, respectively). Among former smokers, hsCRP and carotid intima-media thickness levels and odds of ankle-brachial index ≤1.0 and CAC >0 were lower with increasing time since quitting (P<0.01). Among current smokers, number of cigarettes per day (intensity) was positively associated with hsCRP (P<0.001) and CAC >0 (P=0.03) after adjusting for duration of smoking. Strong associations were observed between smoking status, burden, and intensity with inflammation (hsCRP) and subclinical atherosclerosis (carotid intima-media thickness, ankle-brachial index, CAC). These markers of early cardiovascular disease injury may be

  7. A new ELSA time series of tephra layers and paleobotanical evidence from laminated Eifel maar sediments covering the entire last 120,000 years

    NASA Astrophysics Data System (ADS)

    Sirocko, Frank; Knapp, Hannes; Klee, Marlies; Rothacker, Leo; Kromer, Bernd

    2014-05-01

    The ELSA Project has drilled a total of 50 sediment cores (2000 m of laminated lake sediment) from Eifel maar lakes and dry maar structures during the last 15 years. These records have been dated using 7 different methods, including 370 14C dates. Ten records reveal the established palynological succession of trees during the Holocene down to the Laacher See Tephra, which is used for synchronization with seven more recently drilled laminated sediment cores, which all are 14C-dated too and analyzed for tephra, pollen and paleobotanical macroremains. The seven newly established records reveal a continuous MIS2 section with mosses, ostracods and characea oogonia. They show that the 28.000 - 40.000 BP has witnessed an open landscape dominated by grass, but with rhythmic spread of conifer trees following the Greenland interstadial/succession. Seeds of Ranunculae provide excellent material for 14C dating. Even deciduous trees are present in small amounts until 28.000 BP. The time from 48.000 to 40.000 BP is characterized by a pronounced transition from the open landscape to an early MIS3 spruce (Picea) dominated forest during Greenland Interstadial GI17-14. Modern man apparently arrived at the end of this principal vegetation change near 40,000 BP. Volcanic activity in the Eifel had a stable and pronounced recurrence from 55,000 - 30,000 BP every 4000 years, but commenced with the beginning of MIS2. This landscape evolution with a forested early MIS3 is quite different to peat and sediment records from Netherlands/ Northern Germany/Scandinavia/ Poland, but is similar to conditions in parts of Switzerland. We address the early MIS3 forest to the nearby continuously moist soils and warm conditions in the nearby Mosel valley, i.e. on those stands where wine is growing today, and which most likely had served as a local refugia even for deciduous trees during MIS4 and MIS3. The MIS5 sections of the presented ELSA records reach down at least to the beginning of MIS5d near 118

  8. Beam and spin dynamics in the fast ramping storage ring ELSA: Concepts and measures to increase beam energy, current and polarization

    NASA Astrophysics Data System (ADS)

    Hillert, Wolfgang; Balling, Andreas; Boldt, Oliver; Dieckmann, Andreas; Eberhardt, Maren; Frommberger, Frank; Heiliger, Dominik; Heurich, Nikolas; Koop, Rebecca; Klarner, Fabian; Preisner, Oliver; Proft, Dennis; Pusch, Thorsten; Roth, André; Sauerland, Dennis; Schedler, Manuel; Schmidt, Jan Felix; Switka, Michael; Thiry, Jens-Peter; Wittschen, Jürgen; Zander, Sven

    2017-01-01

    The electron accelerator facility ELSA has been operated for almost 30 years serving nuclear physics experiments investigating the sub-nuclear structure of matter. Within the 12 years funding period of the collaborative research center SFB/TR 16, linearly and circularly polarized photon beams with energies up to more than 3 GeV were successfully delivered to photoproduction experiments. In order to fulfill the increasing demands on beam polarization and intensity, a comprehensive research and upgrade program has been carried out. Beam and spin dynamics have been studied theoretically and experimentally, and sophisticated new devices have been developed and installed. The improvements led to a significant increase of the available beam polarization and intensity. A further increase of beam energy seems feasible with the implementation of superconducting cavities.

  9. Sweetened Soft Drinks Consumption Is Associated with Metabolic Syndrome: Cross-sectional Analysis from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Velasquez-Melendez, Gustavo; Molina, Maria Del Carmen B; Benseñor, Isabela M; Cardoso, Leticia O; Fonseca, Maria de Jesus M; Moreira, Alexandra D; Pereira, Taísa Sabrina S; Barreto, Sandhi M

    2017-02-01

    To estimate the association between regular consumption of sweetened soft drinks, natural fruit juice, and coconut water with metabolic syndrome (MetS). This was a cross-sectional study including men and women aged 35-74 years from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Study, excluding patients with type 2 diabetes. The main explanatory variables were beverage consumption and the outcome variable was metabolic syndrome (Adult Treatment Panel III). After adjustments, a daily intake of 250 ml of soft drink increased the chance of metabolic syndrome (odds ratio [OR] = 1.95; 95% confidence interval [CI], 1.60-2.38). There was no association between coconut water and MetS. Moderate consumption of fruit juices has low odds of MetS compared to no consumption. Our results add evidence to potential negative effects of sweetened soft drinks on cluster metabolic abnormalities in middle-income countries.

  10. Changes in social isolation and loneliness following total hip and knee arthroplasty: longitudinal analysis of the English Longitudinal Study of Ageing (ELSA) cohort.

    PubMed

    Smith, T O; Dainty, J R; MacGregor, A J

    2017-09-01

    To determine the prevalence and change in social isolation and loneliness in people before and after total hip arthroplasty (THA) and total knee arthroplasty (TKA) in England. The English Longitudinal Study of Ageing (ELSA) dataset, a prospective study of community-dwelling older adults, was used to identify people who had undergone primary THA or TKA because of osteoarthritis. Social isolation was assessed using the ELSA Social Isolation Index. Loneliness was evaluated using the Revised University of California, Los Angeles (UCLA) Loneliness Scale. The prevalence of social isolation and loneliness were calculated and multilevel modelling was performed to assess the potential change of these measures before arthroplasty, within a two-year operative-recovery phase and a following two-year follow-up. The sample consisted of 393 people following THA and TKA. The prevalence of social isolation and loneliness changed from 16.9% to 18.8% pre-operative to 21.8% and 18.9% at the final post-operative follow-up respectively. This was not a statistically significant change for either measure (P = 0.15; P = 0.74). There was a significant difference in social isolation at the recovery phase compared to the pre-operative phase (P = 0.01), where people following arthroplasty reported an increase in social isolation (16.9-21.4%). There was no significant difference between the assessment phases in respect to UCLA Loneliness Scale score (P ≥ 0.74). Given the negative physical and psychological consequences which social isolation and loneliness can have on individuals following THA or TKA, clinicians should be mindful of this health challenge for this population. The reported prevalence of social isolation and loneliness suggests this is an important issue. Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  11. Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data.

    PubMed

    Santos, Itamar S; Goulart, Alessandra C; Brunoni, André R; Kemp, Andrew H; Lotufo, Paulo A; Bensenor, Isabela M

    2015-06-01

    Studies focusing on the association between anxiety/depressive symptoms and accelerated subclinical atherosclerosis have yielded mixed results. Our aim is to examine associations between anxiety/depressive symptoms, common mental disorder (CMD), major depression disorder (MDD) or generalized anxiety disorder (GAD) and carotid intima-media thickness (CIMT) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort baseline. The ELSA-Brasil baseline assessment included CIMT measurements and the Clinical Interview Schedule - Revised (CIS-R), a validated questionnaire for anxiety/depressive symptoms/diagnoses. We analyzed participants without previous coronary heart disease or stroke, and with high-quality CIMT images. We built regression models to determine whether the CIS-R score, CMD, MDD or GAD were associated with maximal CIMT levels. The study sample comprised 9744 participants. We found that individuals with higher CIS-R scores (Odds ratio for one standard deviation increase [OR]:1.12; 95% confidence interval [95%CI]:1.06-1.19), CMD (OR:1.22; 95%CI:1.07-1.38) and GAD (OR:1.19; 95%CI:1.01-1.41) had significantly higher odds of being classified in the highest age, sex and race-specific CIMT quartile. In the linear models, after adjustment for traditional cardiovascular risk factors, higher CIS-R scores (β:0.005; P = 0.010) and GAD (β:0.010; P = 0.049) were independently associated with CIMT values. Individuals with more symptoms of anxiety and/or depression, or diagnoses of CMD or GAD, had higher CIMT values, compared to peers of same age, sex and race. CIS-R scores and GAD were independently associated with higher CIMT values. These results suggest an association between anxiety/depressive symptoms (and, most notably, GAD) and accelerated subclinical atherosclerosis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  12. Gender-specific association between night-work exposure and type-2 diabetes: results from longitudinal study of adult health, ELSA-Brasil.

    PubMed

    Silva-Costa, Aline; Rotenberg, Lúcia; Nobre, Aline Araújo; Schmidt, Maria Inês; Chor, Dora; Griep, Rosane Härter

    2015-11-01

    Diabetes is a multifactorial disease of increasing prevalence. The literature suggests an impact of night work on metabolic components, though the relationship with diabetes is unclear. Our aim was to investigate gender-specific associations between night work and type-2 diabetes (DM2) or impaired glucose tolerance (IGT) using baseline data of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The cohort comprised 15 105 civil servants, aged 35-74 years. Baseline assessments (2008-2010) included clinical and laboratory measurements and interviews on sociodemographic, occupational, and health characteristics. In the baseline sample (N=14 427), 19.6% were classified as having DM2 and 20.5% as having IGT. Mean age was 52.1 (SD 9.1) years. A total of 2041 participants worked at night for 1-20 years and 687 for >20 years. Among women exposed to night work for >20 years compared with no night work after adjustments for potential confounders, including obesity, the odds ratios (OR) derived from multinomial logistic regression for DM2 and IGT were 1.42 [95% confidence interval (95% CI) 1.39-1.45] and 0.96 (95% CI 0.94-0.99), respectively. Among men exposed to night work for >20 years compared with no night work, the OR for DM2 and IGT were 1.06 (95% CI 1.04-1.08) and 0.99 (95% CI 0.98-1.01), respectively. The association between years of night work and diabetes is stronger among women than men. Longitudinal studies from ELSA-Brasil will be able to corroborate or refute these findings.

  13. Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease.

    PubMed

    Almeida-Pititto, Bianca de; Ribeiro-Filho, Fernando Flexa; Barreto, Sandhi; Duncan, Bruce B; Schmidt, Maria Inês; Lotufo, Paulo A; Bensenor, Isabela M; Ferreira, Sandra R G

    2016-01-01

    Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.

  14. Lack of association between depression and C-reactive protein level in the baseline of Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    de Menezes, Sara Teles; de Figueiredo, Roberta Carvalho; Goulart, Alessandra Carvalho; Nunes, Maria Angélica; M Benseñor, Isabela; Viana, Maria Carmen; Barreto, Sandhi Maria

    2017-01-15

    Depression has been linked to increased levels of inflammatory markers in clinical studies, but results from general population samples are inconsistent. We aimed to investigate whether depression was associated with serum CRP levels in a cross-sectional analysis of a large cohort from a middle-income country. We analyzed baseline data from 14,821 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Current depression (last 7 days) was assessed by the Clinical Interview Schedule-Revised (CIS-R). Because individuals on antidepressants could be negative on CIS-R due to their therapeutic effect, the explanatory variable had three categories: (1) negative on CIS-R and not using antidepressant (reference); (2) negative on CIS-R but using antidepressant; (3) positive on CIS-R with/without antidepressant use. Associations with CRP were investigated by general linear model (GLM). After adjustments for confounders, neither current depression, nor antidepressant use was statistically associated with elevated CRP levels. Additionally, analyzes stratified by gender, type and severity of depression did not change the results. The reference group in our analysis might include participants with a lifetime history of depression. Additionally, the exclusion of questions on weight fluctuation and appetite from the CIS-R applied in ELSA-Brasil may have slightly underestimated the prevalence of depression, as well as limited our ability to assess the presence of somatic symptoms. This study found no association between current depression, use of antidepressants, and serum CRP levels. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study.

    PubMed

    Pacheco, Antonio G; Grinsztejn, Beatriz; Fonseca, Maria de Jesus M da; Griep, Rosane Härter; Lotufo, Paulo; Bensenor, Isabela; Mill, José G; Moreira, Rodrigo de C; Moreira, Ronaldo I; Friedman, Ruth K; Santini-Oliveira, Marilia; Cardoso, Sandra W; Veloso, Valdiléa G; Chor, Dóra

    2016-01-01

    Carotid intima-media thickness (cIMT) has been used as an early marker of atherosclerotic disease in the general population. Recently its role among HIV-infected patients has been questioned. To date, no Brazilian study has compared cIMT in respect to HIV status. We compared data from 535 patients actively followed in a prospective cohort in Rio de Janeiro (HIV group); 88 HIV-negative individuals who were nominated by patients (friend controls-FCs); and 10,943 participants of the ELSA-Brasil study. Linear regression models were used to study associations of the 3 groups and several covariables with cIMT. Propensity scores weighting (PSW) were also employed to balance data. Median thickness in mm (IQR) were 0.54 (0.49,0.62); 0.58 (0.52,0.68); and 0.57 (0.49,0.70), HIV, FCs and ELSA-Brasil groups, respectively (p-value<0.001). The best linear model chosen did not include the group variables, after adjusting for all the variables chosen, showing no difference of cIMT across groups. Similar results were obtained with PSW. Several traditional CVD risk factors were also significantly associated with cIMT: female gender, higher education and higher HDL were negatively associated while risk factors were older age, current/former smoker, AMI/stroke family history, CVD history, hypertension, DM, higher BMI and total cholesterol. We show for the first time in a middle-income setting that cIMT, is not different in HIV-infected patients in Rio de Janeiro compared with 2 different groups of non-HIV-infected individuals. Traditional CVD risk factors are associated with this outcome. Our results point out that high standards of care and prevention for CVD risk factors should always be sought both in the HIV-infected and non-infected populations to prevent CVD-related events.

  16. Twisted Van der Waals Systems

    NASA Astrophysics Data System (ADS)

    Gani, Satrio; Rossi, Enrico

    Van der Waals systems formed by two-dimensional (2D) crystals and nanostructures possess electronic properties that make them extremely interesting for basic science and for possible technological applications. By tuning the relative angle (the twist angle) between the layers, or nanostructures, forming the Van der Waals systems experimentalists have been able to control the stacking configuration of such systems. We study the dependence on the twist angle of the electronic properties of two classes of Van der Waals systems: double layers formed by two, one-atom thick, layers of a metal dichalcogenide such as molybdenum disulfide (MoS2), and graphene nanoribbons on a hexagonal boron nitride substrate. We present results that show how, for both classes of systems, the electronic properties can be strongly tuned via the twist angle. Work supported by ACS-PRF-53581-DNI5 and NSF-DMR-1455233.

  17. The Dramatic Methods of Hans van Dam.

    ERIC Educational Resources Information Center

    van de Water, Manon

    1994-01-01

    Interprets for the American reader the untranslated dramatic methods of Hans van Dam, a leading drama theorist in the Netherlands. Discusses the functions of drama as a method, closed dramatic methods, open dramatic methods, and applying van Dam's methods. (SR)

  18. Five-body van der Waals interactions

    NASA Astrophysics Data System (ADS)

    Han, Jianing

    2017-06-01

    We report on the five-body repulsive and attractive van der Waals interactions between the strongly dipole-dipole coupled Rydberg states. Compared to four-body van der Waals interactions, five-body van der Waals interactions show more energy levels and more potential wells caused by avoided crossings. This research bridges the few-body physics and many-body physics. Other disciplines, such as chemistry, biology, and medical fields, will also benefit from better understanding van der Waals interactions.

  19. Mobile Telemetry Van Remote Control Upgrade

    DTIC Science & Technology

    2012-05-17

    Advantages of Remote Control System Upgrade • Summary Overview • Remote control of Telemetry Mobile Ground Support ( TMGS ) Van proposed to allow...NWC) personnel provided valuable data for full-function remote control of telemetry tracking vans Background • TMGS Vans support Flight Test...control capability from main TM site at Building 5790 currently allows support via TMGS Van at nearby C- 15 Site, Plant 42 in Palmdale, and as far

  20. Automatic hybrid electric lumina van

    SciTech Connect

    Ellers, C.W.

    1995-12-31

    A parallel/Series split-drive hybrid system driving a seven passenger Lumina van is described. The series type hybrid uses a heat-engine driven generator to charge the batteries and/or supply power to the electric drive motor. Volvo is now showing the Volvo ECC (Environmental Concept Car) which is one of the best examples of the series hybrid concept.

  1. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets,...

  2. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

  3. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

  4. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

  5. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

  6. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study

    PubMed Central

    Grinsztejn, Beatriz; da Fonseca, Maria de Jesus M.; Griep, Rosane Härter; Lotufo, Paulo; Bensenor, Isabela; Mill, José G.; Moreira, Rodrigo de C.; Moreira, Ronaldo I.; Friedman, Ruth K.; Santini-Oliveira, Marilia; Cardoso, Sandra W.; Veloso, Valdiléa G.; Chor, Dóra

    2016-01-01

    Background Carotid intima-media thickness (cIMT) has been used as an early marker of atherosclerotic disease in the general population. Recently its role among HIV-infected patients has been questioned. To date, no Brazilian study has compared cIMT in respect to HIV status. Methods We compared data from 535 patients actively followed in a prospective cohort in Rio de Janeiro (HIV group); 88 HIV-negative individuals who were nominated by patients (friend controls–FCs); and 10,943 participants of the ELSA-Brasil study. Linear regression models were used to study associations of the 3 groups and several covariables with cIMT. Propensity scores weighting (PSW) were also employed to balance data. Results Median thickness in mm (IQR) were 0.54 (0.49,0.62); 0.58 (0.52,0.68); and 0.57 (0.49,0.70), HIV, FCs and ELSA-Brasil groups, respectively (p-value<0.001). The best linear model chosen did not include the group variables, after adjusting for all the variables chosen, showing no difference of cIMT across groups. Similar results were obtained with PSW. Several traditional CVD risk factors were also significantly associated with cIMT: female gender, higher education and higher HDL were negatively associated while risk factors were older age, current/former smoker, AMI/stroke family history, CVD history, hypertension, DM, higher BMI and total cholesterol. Conclusions We show for the first time in a middle-income setting that cIMT, is not different in HIV-infected patients in Rio de Janeiro compared with 2 different groups of non-HIV-infected individuals. Traditional CVD risk factors are associated with this outcome. Our results point out that high standards of care and prevention for CVD risk factors should always be sought both in the HIV-infected and non-infected populations to prevent CVD-related events. PMID:27391355

  7. Brazilian dietary patterns and the dietary approaches to stop hypertension (DASH) diet-relationship with metabolic syndrome and newly diagnosed diabetes in the ELSA-Brasil study.

    PubMed

    Drehmer, Michele; Odegaard, Andrew O; Schmidt, Maria Inês; Duncan, Bruce B; Cardoso, Letícia de Oliveira; Matos, Sheila M Alvim; Molina, Maria Del Carmen B; Barreto, Sandhi M; Pereira, Mark A

    2017-01-01

    Studies evaluating dietary patterns, including the DASH diet, and their relationship with the metabolic syndrome and diabetes may help to understand the role of dairy products (low fat or full fat) in these conditions. Our aim is to identify dietary patterns in Brazilian adults and compare them with the (DASH) diet quality score in terms of their associations with metabolic syndrome and newly diagnosed diabetes in the Brazilian Longitudinal Study of Adult Health-the ELSA-Brasil study. The ELSA-Brasil is a multicenter cohort study comprising 15,105 civil servants, aged 35-74 years at baseline (2008-2010). Standardized interviews and exams were carried out, including an OGTT. We analyzed baseline data for 10,010 subjects. Dietary patterns were derived by principal component analysis. Multivariable logistic regression investigated associations of dietary patterns with metabolic syndrome and newly diagnosed diabetes and multivariable linear regression with components of metabolic syndrome. After controlling for potential confounders, we observed that greater adherence to the Common Brazilian meal pattern (white rice, beans, beer, processed and fresh meats), was associated with higher frequencies of newly diagnosed diabetes, metabolic syndrome and all of its components, except HDL-C. Participants with greater intake of a Common Brazilian fast foods/full fat dairy/milk based desserts pattern presented less newly diagnosed diabetes. An inverse association was also seen between the DASH Diet pattern and the metabolic syndrome, blood pressure and waist circumference. Diet, light foods and beverages/low fat dairy pattern was associated with more prevalence of both outcomes, and higher fasting glucose, HDL-C, waist circumference (among men) and lower blood pressure. Vegetables/fruit dietary pattern did not protect against metabolic syndrome and newly diagnosed diabetes but was associated with lower waist circumference. The inverse associations found for the dietary pattern

  8. Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Peixoto de Miranda, É J F; Bittencourt, M S; Pereira, A C; Goulart, A C; Santos, I S; Lotufo, P A; Bensenor, I M

    2016-10-01

    Although subclinical hypothyroidism (SCH) is associated with cardiovascular risk, there is scarce data about subclinical atherosclerosis in subjects with SCH. We aimed to analyze the association between SCH and carotid intima-media thickness (IMT) using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We included subjects with normal thyroid function (TSH: 0.4-4.0 mIU/l, and normal free thyroxine (FT4): 0.8-1.9 ng/dl) and SCH (TSH ≥ 4.0 mIU/l and normal FT4) evaluated for IMT in a cross-sectional analysis. We excluded individuals using medications that affect thyroid function and those with a history of cardiovascular disease. We performed logistic and linear regression models to evaluate the association with IMT (mean values and categorized at the 75th percentile) as a dependent variable and SCH as an independent variable, adjusted for other cardiovascular risk factors. From 8623 subjects (median age of 50 years; interquartile range: 44-57), 4624 (53.6%) were women, 8095 (93.9%) were euthyroid, and 528 (6.1%) had SCH. Groups varied in age, body mass index, Framingham risk score, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), C-reactive protein, as well as, IMT, that were all higher in SCH compared to euthyroid participants. SCH is associated with IMT as a continuous variable (β = 0.010, P = 0.036) and IMT >75th percentile: OR = 1.30 (95% CI = 1.06-1.59) in logistic models. Individuals with SCH presented higher IMT compared with euthyroid subjects, even after adjustment for potential confounders. IMT was independently associated with SCH in the baseline of the ELSA-Brasil study. Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

  9. Serum uric acid is associated with better executive function in men but not in women: Baseline assessment of the ELSA-Brasil study.

    PubMed

    Baena, Cristina Pellegrino; Suemoto, Claudia Kimie; Barreto, Sandhi Maria; Lotufo, Paulo Andrade; Benseñor, Isabela

    2017-06-01

    Serum uric acid (SUA) may protect against free radical stress damage and was previously linked to cognitive impairment in older adults, but evidence in middle-aged adults is scarce. We sought to analyze whether SUA is associated with cognitive performance in apparently healthy middle-aged participants in the ELSA-Brasil cohort study. We excluded participants older than age 65, those taking allopurinol, benzbromarone, or medications that could impair cognitive performance, those with previous stroke, and those with incomplete data on cognitive tests or SUA. The Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (CERAD-WLMT), the Semantic Fluency Test (SFT), and the Trail Making Test version B (TMT) were used as dependent variables. Sex-specific linear regression models were used to assess the association between SUA and cognitive tests, adjusted by age, education, hypertension, dyslipidemia, diabetes, smoking, alcohol consumption, body mass index, coronary heart disease, renal function, depression, aspirin use, thyroid function, and menopausal status (in women). We used the Bonferroni procedure to control for the false discovery rate associated with multiple comparisons. We analyzed cross-sectional data from 6751 women and 5464 men. Mean age and standard deviation (SD) of the sample was 49.6 (SD 7.4) years for men and 49.9 (SD 7.3) years for women. The majority of men (52%) and women (51%) were white. Mean SUA value was 4.75 (SD 1.16) mg/dL in women and 6.44 (SD 1.39) mg/dL in men. Multivariate linear models showed no association in women and a significant inverse association between SUA levels and TMT (β=-3.106, 95% CI=-4.594; -1.618, p=0.0004) in men. In a middle-aged subset population, SUA is associated with better performance on an executive function test in men, but not in women in the ELSA-Brasil cohort study. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    de Almeida-Pititto, Bianca; Ribeiro-Filho, Fernando Flexa; Bittencourt, Marcio Sommer; Lotufo, Paulo A; Bensenor, Isabela; Ferreira, Sandra R G

    2016-01-01

    This cross-sectional analysis evaluated whether determination of E-selectin concentrations could identify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health-ELSA-Brasil. A sample of 984 individuals from ELSA-Brasil (35-54 years) without cardiovascular disease or diabetes was stratified according to E-selectin tertiles. Traditional risk factors, inflammatory markers and categories of coronary artery calcium (CAC) scores were evaluated across the tertiles by ANOVA or Chi-squared test. In linear regression models, associations of E-selectin levels with insulin resistance index, adjusted for age, sex and adiposity were tested. The mean age of the participants was 45.8 (SD 4.9) years and 55 % were women. Mean values of age, anthropometric data, biochemical variables and inflammatory status increased across E-selectin tertiles. Also, a gradual deterioration of the cardiometabolic profile was reflected by increments in frequencies (95 % CI) of BMI ≥ 25 kg/m(2) [53.7 % (48.5-58.8), 61.0 % (56.1-66.5) and 64.2 % (59.0-69.4), p = 0.019], hypertension [18.0 % (14.1-22.8), 19.8 % (15.4-24.6) and 24.8 % (20.4-29.9), p = 0.048], pre-diabetes [62.5 % (57.4-68.3), 63.1 % (58.4-69.6) and 73.8 % (68.8-78.3), p = 0.003] and hypertriglyceridemia [22.4 % (17.9-27.2), 27.3 % (22.5-32.8) and 33.4 % (28.3-38.5), p = 0.013]. Insulinemia and HOMA-IR were independently associated with E-selectin concentration. A greater proportion of individuals with CAC scores different from zero was found in the third tertile when compared with the first and second tertiles (16.1 versus 11 %, p = 0.04, respectively). Direct associations of E-selectin with traditional risk factors slightly above their normal ranges, components of the metabolic syndrome, insulin resistance and presence of CAC suggest that this biomarker may indicate an initial

  11. Occurrence of the vancomycin-resistant genes vanA, vanB, vanCl, vanC2 and vanC3 in Enterococcus strains isolated from poultry and pork.

    PubMed

    Lemcke, R; Bülte, M

    2000-09-25

    It is suspected that the use of avoparcin as a feeding antibiotic for the fat stock contributes to development of cross-resistance against vancomycin and teicoplanin. After isolating enterococci strains from poultry and pork meat by cultivation on citrate azide Tween carbonate agar (CATC) and screening the vancomycin resistance on Columbia colistin nalidixic acid agar (CNA, supplemented with 5% sheepblood and 5 mg vancomycin/l) the polymerase chain reaction (PCR) was used for the detection of the vancomycin resistance genes vanA ('high level'), vanB ('moderate high level'), vanC1, vanC2 and vanC3 ('low level'). Out of 1643 E.-isolates from 115 poultry and 50 pork samples, 420 isolates could be identified as vancomycin resistant, 202 isolates of which carry the vanA, one isolate both the vanA and the vanC1, 38 isolates the vanC1, 14 isolates the vanC2, nine isolates both the vanC1 and the vanC3 gene and 156 isolates carry no gene. The vanB gene was not found in these isolates. Comparing vanA-positive food isolates with those from different human sources by means of the pulsed field gel electrophoresis (PFGE) it could clearly be demonstrated that they do not show homological fingerprints according to the source of origin. It is therefore unlikely that there is a close genetic relationship between isolates from animal foodstuff and humans.

  12. Association between maternal education and blood pressure: mediation evidence through height components in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Rodríguez López, Santiago; Bensenor, Isabela M; Giatti, Luana; Molina, Maria Del Carmen; Lotufo, Paulo A

    2017-05-01

    Maternal education influences skeletal growth and offspring adult blood pressure (BP). Height components are negatively associated with BP in high-income countries. To evaluate the association between maternal education and offspring adult systolic and diastolic BP (SBP/DBP), assessing whether different height components might mediate such an association. Simple mediation modelling was used to evaluate the maternal education-offspring SBP/DBP association, estimating the contribution of offspring height components, in a cross-sectional sample of 13 571 Brazilians aged 34-75 from the ELSA-Brasil study. After full adjustment for confounders, and compared to participants whose mothers received low education, those whose mothers received high education had, on average, 0.2 mm Hg lower SBP (95% CI = -0.274, -0.132), as result of the link between maternal education and offspring adult height which, in turn, influenced SBP. Thus, 18-26% of the maternal education-SBP association occurred indirectly, through height, trunk and leg length, alternatively. Better maternal education might influence higher leg and trunk lengths in offspring, which, in turn, might contribute to prevent higher BP in adults. The negative height-BP association reported in high-income countries is also present in a middle-income country with more recent economic development.

  13. Multinomial model and zero-inflated gamma model to study time spent on leisure time physical activity: an example of ELSA-Brasil.

    PubMed

    Nobre, Aline Araújo; Carvalho, Marilia Sá; Griep, Rosane Härter; Fonseca, Maria de Jesus Mendes da; Melo, Enirtes Caetano Prates; Santos, Itamar de Souza; Chor, Dora

    2017-08-17

    To compare two methodological approaches: the multinomial model and the zero-inflated gamma model, evaluating the factors associated with the practice and amount of time spent on leisure time physical activity. Data collected from 14,823 baseline participants in the Longitudinal Study of Adult Health (ELSA-Brasil - Estudo Longitudinal de Saúde do Adulto ) have been analysed. Regular leisure time physical activity has been measured using the leisure time physical activity module of the International Physical Activity Questionnaire. The explanatory variables considered were gender, age, education level, and annual per capita family income. The main advantage of the zero-inflated gamma model over the multinomial model is that it estimates mean time (minutes per week) spent on leisure time physical activity. For example, on average, men spent 28 minutes/week longer on leisure time physical activity than women did. The most sedentary groups were young women with low education level and income. The zero-inflated gamma model, which is rarely used in epidemiological studies, can give more appropriate answers in several situations. In our case, we have obtained important information on the main determinants of the duration of leisure time physical activity. This information can help guide efforts towards the most vulnerable groups since physical inactivity is associated with different diseases and even premature death.

  14. Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA)

    PubMed Central

    Souza-Teodoro, Luis H; de Oliveira, Cesar; Walters, Kate; Carvalho, Livia A

    2016-01-01

    Depression is one of the major causes of disability worldwide, but the complete etiology of depression is not fully understood. Dehydroepiandrosterone (DHEA) and its sulphated form DHEA(S) have been associated with mood and healthy aging. Associations with mental illness over the middle to late years of life have not yet been extensively investigated in large, western community-dwelling samples. The aim of this study was to investigate whether low DHEA(S) levels are associated with the development of depressive symptoms in a large longitudinal cohort study of older men and women. We assessed data from English Longitudinal Study of Aging (ELSA) to evaluate the association of DHEA(S) levels and depressive symptoms measured by Center for Epidemiologic Studies Scale (CES-D) at baseline (n = 3083) and at 4-year follow-up (n = 3009). At baseline, there was an inverse association between DHEA(S) and depressive symptoms (B = −0.252, p = 0.014). Adjustments for physical illnesses, impairments in cognitive function and health behaviors abolished this association (p = 0.109) at baseline. Decreased DHEA(S) levels at baseline also predicted incident depression at 4-year follow-up (B = −0.332, p < 0.001). In conclusion, higher DHEA(S) levels were associated with reduced risk of developing depressive symptoms in both men and women. PMID:26600009

  15. James A. Van Allen (1914-2006)

    NASA Astrophysics Data System (ADS)

    2006-08-01

    James A. Van Allen, who served as presidentof AGU from 1982 to 1984, died on 9August. Van Allen was president of the PlanetarySciences Section from 1964 to 1968 andpresident of the Solar-Planetary RelationshipsSection (now the Space Physics andAeronomy Section) from 1976 to 1978. Hewas awarded the John Adam Fleming Medalin 1963 and the William Bowie Medal in1977. Van Allen joined AGU in 1948.

  16. 77 FR 64580 - Noise Exposure Map Notice for Van Nuys Airport, Van Nuys, California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... Angeles World Airports, Environmental Services Division, 7301 World Way West, 3rd Floor, Los Angeles... Federal Aviation Administration Noise Exposure Map Notice for Van Nuys Airport, Van Nuys, California... Airports, for Van Nuys Airport under the provisions of 49 U.S.C. 47501 et seq. (Aviation Safety and...

  17. Indoor Radon Measurement in Van

    SciTech Connect

    Kam, E.; Osmanlioglu, A. E.; Celebi, N.; Dogan, I.

    2007-04-23

    In this study, indoor radon concentrations obtained from the radon surveys conducted in the Van. Radon monitoring was performed by applying a passive, time-integrating measuring technique. For this purpose, CR-39 nuclear track detectors were installed in dwellings for 2 months. After the monitoring period, detectors were collected. In order to make the alpha tracks visible, chemical etching was applied to the exposed detectors. Nuclear track numbers and the corresponding indoor radon concentrations were determined. Annual effective dose equivalents and the risk probabilities caused by indoor radon inhalation were calculated, and the found results compared with the indoor radon concentrations' data measured in different provinces of Turkey.

  18. Van Go: A Labor of Love

    ERIC Educational Resources Information Center

    Williams, Jennifer

    2012-01-01

    Like a tapestry woven with one outstanding thread from beginning to end, the author's forty-year tenure as an art educator has its golden thread in her Van Go art outreach project. Quite literally, she takes students in a "van" and they "go," mostly on dirt roads, taking art to rural schools in Idaho, some of which have no more…

  19. Van Go: A Labor of Love

    ERIC Educational Resources Information Center

    Williams, Jennifer

    2012-01-01

    Like a tapestry woven with one outstanding thread from beginning to end, the author's forty-year tenure as an art educator has its golden thread in her Van Go art outreach project. Quite literally, she takes students in a "van" and they "go," mostly on dirt roads, taking art to rural schools in Idaho, some of which have no more…

  20. Race and Resting-State Heart Rate Variability in Brazilian Civil Servants and the Mediating Effects of Discrimination: An ELSA-Brasil Cohort Study.

    PubMed

    Kemp, Andrew H; Koenig, Julian; Thayer, Julian F; Bittencourt, Marcio S; Pereira, Alexandre C; Santos, Itamar S; Dantas, Eduardo M; Mill, José G; Chor, Dora; Ribeiro, Antonio L P; Benseñor, Isabela M; Lotufo, Paulo A

    2016-10-01

    African Americans are characterized by higher heart rate variability (HRV), a finding ostensibly associated with beneficial health outcomes. However, these findings are at odds with other evidence that blacks have worse cardiovascular outcomes. Here, we examine associations in a large cohort from the ELSA-Brasil study and determined whether these effects are mediated by discrimination. Three groups were compared on the basis of self-declared race: "black" (n = 2,020), "brown" (n = 3,502), and "white" (n = 6,467). Perceived discrimination was measured using a modified version of the Everyday Discrimination Scale. Resting-state HRV was extracted from 10-minute resting-state electrocardiograms. Racial differences in HRV were determined by regression analyses weighted by propensity scores, which controlled for potentially confounding variables including age, sex, education, and other health-related information. Nonlinear mediation analysis quantified the average total effect, comprising direct (race-HRV) and indirect (race-discrimination-HRV) pathways. Black participants displayed higher HRV relative to brown (Cohen's d = 0.20) and white participants (Cohen's d = 0.31). Brown relative to white participants also displayed a small but significantly higher HRV (Cohen's d = 0.14). Discrimination indirectly contributed to the effects of race on HRV. This large cohort from the Brazilian population shows that HRV is greatest in black, followed by brown, relative to white participants. The presence of higher HRV in these groups may reflect a sustained compensatory psychophysiological response to the adverse effects of discrimination. Additional research is needed to determine the health consequences of these differences in HRV across racial and ethnic groups.

  1. Cross-Sectional Study of Sleep Quantity and Quality and Amnestic and Non-Amnestic Cognitive Function in an Ageing Population: The English Longitudinal Study of Ageing (ELSA)

    PubMed Central

    Miller, Michelle A.; Wright, Hayley; Ji, Chen; Cappuccio, Francesco P.

    2014-01-01

    Background The aim was to investigate the association between sleep disturbances and cognitive function in younger and older individuals from an ageing population. Methods 3,968 male and 4,821 female white participants, aged 50 years and over, from the English Longitudinal Study of Ageing (ELSA) were studied. Information on sleep quality and quantity as well as both amnestic (memory, ACF) and non-amnestic (non-memory, nACF) function was available at Wave 4 (2008). Analysis of covariance was used to evaluate the relationship between sleep and cognitive function. Results After adjustment for multiple confounders in the younger group (50–64 years) duration of sleep explained 15.2% of the variance in ACF (p = 0.003) and 20.6% of nACF (p = 0.010). In the older group (65+ years) the estimates were 21.3% (p<0.001) and 25.6% (p<0.001), respectively. For sleep quality, there was a statistically significant association between sleep quality and both ACF (p<0.001) and nACF (p<0.001) in the older age group, but not in the younger age group (p = 0.586 and p = 0.373, respectively; interaction between age and sleep quality in the study sample including both age groups: p<0.001 for ACF and p = 0.018 for nACF). Sleep quality explained between 15.1% and 25.5% of the variance in cognition. The interaction with age was independent of duration of sleep. At any level of sleep duration there was a steeper association between sleep quality and ACF in the older than the younger group. Conclusions The associations between sleep disturbances and cognitive function vary between younger and older adults. Prospective studies will determine the temporal relationships between sleep disturbances and changes in cognition in different age groups. PMID:24968354

  2. Job Strain and Casual Blood Pressure Distribution: Looking beyond the Adjusted Mean and Taking Gender, Age, and Use of Antihypertensives into Account. Results from ELSA-Brasil

    PubMed Central

    Juvanhol, Leidjaira Lopes; Melo, Enirtes Caetano Prates; Carvalho, Marilia Sá; Chor, Dóra; Mill, José Geraldo; Griep, Rosane Härter

    2017-01-01

    Methodological issues are pointed to as the main sources of inconsistencies in studies about the association between job strain and blood pressure (BP)/hypertension. Our aim was to analyze the relationship between job strain and the whole BP distribution, as well as potential differences by gender, age, and use of antihypertensives. Additionally, we addressed issues relating to the operationalization of the exposure and outcome variables that influence the study of their inter-relations. We evaluated the baseline date of 12,038 participants enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) (2008–2010), a multicenter cohort study of 35–74-year-old civil servants. Job strain was assessed by the Demand-Control-Support Questionnaire. The distribution of casual BP by categories of job strain was compared by a combination of exploratory techniques. Participants were classified into three subgroups (normotensives, medicated hypertensives, and unmedicated hypertensives), and analyses were stratified by gender and age. The relationship between job strain and casual BP varied along the whole outcome distribution. Hypertensive participants had greater differences in casual BP by job strain category, especially medicated hypertensives. Differences in casual BP were also greater for systolic than for diastolic BP and for older participants. No differences were encountered by gender. The exclusion of participants susceptible to misclassification for the exposure and outcome variables increased the differences observed between the categories of low and high job strain. In conclusion, the relationship between job strain and casual BP varied along the whole outcome distribution and by use of antihypertensive drugs, age, and BP parameter evaluated. Misclassification for exposure and outcome variables should be considered in analyses of this topic. PMID:28441727

  3. Prevalence, Awareness, Treatment and Influence of Socioeconomic Variables on Control of High Blood Pressure: Results of the ELSA-Brasil Study

    PubMed Central

    Chor, Dóra; Pinho Ribeiro, Antonio Luiz; Sá Carvalho, Marilia; Duncan, Bruce Bartholow; Andrade Lotufo, Paulo; Araújo Nobre, Aline; de Aquino, Estela Mota Lima Leão; Schmidt, Maria Inês; Griep, Rosane Härter; Molina, Maria Del Carmen Bisi; Barreto, Sandhi Maria; Passos, Valéria Maria de Azeredo; Benseñor, Isabela Judith Martins; Matos, Sheila Maria Alvim; Mill, José Geraldo

    2015-01-01

    High blood pressure (HBP) is the leading risk factor for years of life lost in Brazil. Factors associated with HBP awareness, treatment and control need to be understood better. Our aim is to estimate prevalence, awareness, and types of anti-hypertensive treatment and to investigate the association of HBP control with social position. Data of 15,103 (54% female) civil servants in six Brazilian state capitals collected at the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline (2008-2010) were used to estimate prevalence and cross-sectional association of HBP control with education, per capita family income and self-reported race, using multiple logistic regression. Blood pressure was measured by the oscillometric method. 35.8% were classified as presenting HBP; 76.8% of these used anti-hypertensive medication. Women were more aware than men (84.8% v. 75.8%) and more often using medication (83.1% v. 70.7%). Adjusted HBP prevalence was, in ascending order, Whites (30.3%), Browns (38.2%) and Blacks (49.3%). The therapeutic schemes most used were angiotensin-converting enzyme inhibitors, in isolation (12.4%) or combined with diuretics (13.3%). Among those in drug treatment, controlled blood pressure was more likely in the (postgraduate) higher education group than among participants with less than secondary school education (PR = 1.21; 95% CI: 1.14–1.28), and among Asian (PR = 1.21; 95% CI: 1.12–1.32) and ‘Whites (PR = 1.19; 95% CI: 1.12–1.26) compared to Blacks. Socioeconomic and racial inequality—as measured by different indicators—are strongly associated with HBP control, beyond the expected influence of health services access. PMID:26102079

  4. Leisure-time and commuting physical activity and high blood pressure: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Treff, C; Benseñor, I M; Lotufo, P A

    2017-04-01

    This study investigates the association between leisure-time physical activity and commuting-related physical activity and high blood pressure among participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Physical activity was assessed through application of the International Physical Activity Questionnaire, particularly the domains addressing leisure and transportation. We used the World Health Organization's definition (⩾150 min per week of moderate activities or 75 min per week of vigorous activities) to establish three categories: active, insufficiently active and inactive. Hypertension was defined as systolic/diastolic blood pressure of >140/90 mm Hg or use of antihypertensive medications. From a universe of 15 105 participants, we analysed 13 857 subjects without previous cardiovascular diseases. The association between physical activity and hypertension was obtained using Poisson regression with adjustment for age, race, education, income, body mass index, diabetes and sodium and alcohol intake. Men who were active during leisure time had a multivariate prevalence ratio (95% confidence interval) of 0.84 (0.77-0.92) for hypertension compared with inactive men. For women, the prevalence ratio of active vs inactive during leisure time was 0.86 (0.79-0.95). However, this protective effect of leisure-time physical activity was not observed among men and women with diabetes or obese women. The association found between commuting-related physical activity and hypertension was not detected among men, and the prevalence ratio for women who were active during commuting time compared with inactive women was 1.11 (1.01-1.21). In conclusion, leisure-time physical activity was protective against hypertension, and commuting-related physical activity was associated with high blood pressure among women.

  5. Prevalence, Awareness, Treatment and Influence of Socioeconomic Variables on Control of High Blood Pressure: Results of the ELSA-Brasil Study.

    PubMed

    Chor, Dóra; Pinho Ribeiro, Antonio Luiz; Sá Carvalho, Marilia; Duncan, Bruce Bartholow; Andrade Lotufo, Paulo; Araújo Nobre, Aline; Aquino, Estela Mota Lima Leão de; Schmidt, Maria Inês; Griep, Rosane Härter; Molina, Maria Del Carmen Bisi; Barreto, Sandhi Maria; Passos, Valéria Maria de Azeredo; Benseñor, Isabela Judith Martins; Matos, Sheila Maria Alvim; Mill, José Geraldo

    2015-01-01

    High blood pressure (HBP) is the leading risk factor for years of life lost in Brazil. Factors associated with HBP awareness, treatment and control need to be understood better. Our aim is to estimate prevalence, awareness, and types of anti-hypertensive treatment and to investigate the association of HBP control with social position. Data of 15,103 (54% female) civil servants in six Brazilian state capitals collected at the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline (2008-2010) were used to estimate prevalence and cross-sectional association of HBP control with education, per capita family income and self-reported race, using multiple logistic regression. Blood pressure was measured by the oscillometric method. 35.8% were classified as presenting HBP; 76.8% of these used anti-hypertensive medication. Women were more aware than men (84.8% v. 75.8%) and more often using medication (83.1% v. 70.7%). Adjusted HBP prevalence was, in ascending order, Whites (30.3%), Browns (38.2%) and Blacks (49.3%). The therapeutic schemes most used were angiotensin-converting enzyme inhibitors, in isolation (12.4%) or combined with diuretics (13.3%). Among those in drug treatment, controlled blood pressure was more likely in the (postgraduate) higher education group than among participants with less than secondary school education (PR = 1.21; 95% CI: 1.14-1.28), and among Asian (PR = 1.21; 95% CI: 1.12-1.32) and 'Whites (PR = 1.19; 95% CI: 1.12-1.26) compared to Blacks. Socioeconomic and racial inequality-as measured by different indicators-are strongly associated with HBP control, beyond the expected influence of health services access.

  6. Associations of life course socioeconomic position and job stress with carotid intima-media thickness. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Camelo, Lidyane V; Giatti, Luana; Chor, Dóra; Griep, Rosane Härter; Benseñor, Isabela M; Santos, Itamar S; Kawachi, Ichiro; Barreto, Sandhi Maria

    2015-09-01

    The association between life course socioeconomic position (SEP) and subclinical atherosclerosis is not consistent across studies. Socioeconomic adversities early in life are related to an increased probability of a low occupational grade and more stressful jobs in adulthood. However, the role of job stress in explaining the life course social gradient in subclinical atherosclerosis is unknown. To examine whether life course SEP is associated with carotid intima-media thickness (IMT) and to investigate whether this association is partially mediated by job stress. This study used baseline data (2008-2010) for 8806 current workers from ELSA-Brasil. Maternal education, social class of first occupation and social class of current occupation were used to evaluate childhood, youth and adulthood SEP, respectively. Accumulation of risk across the life course was also evaluated. Job stress was assessed by the Swedish Demand-Control-Support Questionnaire. Directed acyclic graph and linear regression models were used. Low childhood SEP was associated with increased IMT only in women, but low youth and adulthood SEP were associated with higher IMT in both genders. The simultaneous adjustment for all SEP indicators showed that only adulthood SEP continued to be associated with IMT. However, higher IMT values were observed among men and women sequentially exposed to low SEP in more than one period of life. High-strain jobs and low job control were not associated with IMT independent of SEP. Our results support a model of the cumulative effects of exposures to SEP across the life span because the highest IMT values were observed in individuals sequentially exposed to low SEP in more than one period of life. We did not find that job stress explained the association between life course SEP and IMT, suggesting that strategies to address socioeconomic inequalities in CVD should target additional steps beyond reducing job stress. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Gender, race and socioeconomic influence on diagnosis and treatment of thyroid disorders in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Olmos, R D; Figueiredo, R C de; Aquino, E M; Lotufo, P A; Bensenor, I M

    2015-08-01

    Thyroid diseases are common, and use of levothyroxine is increasing worldwide. We investigated the influence of gender, race and socioeconomic status on the diagnosis and treatment of thyroid disorders using data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicenter cohort study of civil servants (35-74 years of age) from six Brazilian cities. Diagnosis of thyroid dysfunction was by thyrotropin (TSH), and free thyroxine (FT4) if TSH was altered, and the use of specific medications. Multivariate logistic regression models were constructed using overt hyperthyroidism/hypothyroidism and levothyroxine use as dependent variables and sociodemographic characteristics as independent variables. The frequencies of overt hyper- and hypothyroidism were 0.7 and 7.4%, respectively. Using whites as the reference ethnicity, brown, and black race were protective for overt hypothyroidism (OR=0.76, 95%CI=0.64-0.89, and OR=0.53, 95%CI=0.43-0.67, respectively, and black race was associated with overt hyperthyroidism (OR=1.82, 95%CI=1.06-3.11). Frequency of hypothyroidism treatment was higher in women, browns, highly educated participants and those with high net family incomes. After multivariate adjustment, levothyroxine use was associated with female gender (OR=6.06, 95%CI=3.19-11.49) and high net family income (OR=3.23, 95%CI=1.02-10.23). Frequency of hyperthyroidism treatment was higher in older than in younger individuals. Sociodemographic factors strongly influenced the diagnosis and treatment of thyroid disorders, including the use of levothyroxine.

  8. Thyrotropin Levels, Insulin Resistance, and Metabolic Syndrome: A Cross-Sectional Analysis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Benseñor, Isabela M; Goulart, Alessandra Carvalho; Molina, Maria del Carmen B; de Miranda, Érique José Peixoto; Santos, Itamar S; Lotufo, Paulo A

    2015-10-01

    Previous studies have described an association with thyrotropin (TSH) levels, insulin resistance, and metabolic syndrome. We performed a cross-sectional analysis to investigate the relationship between TSH levels, insulin resistance, and metabolic syndrome using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetics and individuals using medications that interfere in thyroid function were excluded, leaving 10,935 participants (54.3% women) for current analyses. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) values above the 75th percentile was considered as indicative of presence of insulin resistance. Logistic regression models were built using HOMA-IR and metabolic syndrome as the dependent variable, and quintiles of TSH as the independent variable (first quintile as reference). Odds ratios (OR) were presented with multivariate adjustment for socioeconomic/cardiovascular risk factors for insulin resistance, and adjustment only for socioeconomic factors and smoking for metabolic syndrome. Age, body mass index, waist measurement, fasting glucose and fasting and post load insulin and HOMA-IR increased according to TSH quintiles. Subjects in the fifth TSH quintile presented an OR of association with insulin resistance of 1.86 [95% confidence interval (95% CI) 1.26-2.75], regardless of gender. For the metabolic syndrome, subjects in the fifth quintile presented an OR of 1.21 (95% CI 1.01-1.45) and remained positive only for men (OR 1.37; 95% CI 1.07-1.76). Restricting the analysis to quintiles of TSH in the normal range did not change the results. In this cross-sectional evaluation, high TSH quintiles were associated to insulin resistance/metabolic syndrome.

  9. Job Strain and Casual Blood Pressure Distribution: Looking beyond the Adjusted Mean and Taking Gender, Age, and Use of Antihypertensives into Account. Results from ELSA-Brasil.

    PubMed

    Juvanhol, Leidjaira Lopes; Melo, Enirtes Caetano Prates; Carvalho, Marilia Sá; Chor, Dóra; Mill, José Geraldo; Griep, Rosane Härter

    2017-04-22

    Methodological issues are pointed to as the main sources of inconsistencies in studies about the association between job strain and blood pressure (BP)/hypertension. Our aim was to analyze the relationship between job strain and the whole BP distribution, as well as potential differences by gender, age, and use of antihypertensives. Additionally, we addressed issues relating to the operationalization of the exposure and outcome variables that influence the study of their inter-relations. We evaluated the baseline date of 12,038 participants enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) (2008-2010), a multicenter cohort study of 35-74-year-old civil servants. Job strain was assessed by the Demand-Control-Support Questionnaire. The distribution of casual BP by categories of job strain was compared by a combination of exploratory techniques. Participants were classified into three subgroups (normotensives, medicated hypertensives, and unmedicated hypertensives), and analyses were stratified by gender and age. The relationship between job strain and casual BP varied along the whole outcome distribution. Hypertensive participants had greater differences in casual BP by job strain category, especially medicated hypertensives. Differences in casual BP were also greater for systolic than for diastolic BP and for older participants. No differences were encountered by gender. The exclusion of participants susceptible to misclassification for the exposure and outcome variables increased the differences observed between the categories of low and high job strain. In conclusion, the relationship between job strain and casual BP varied along the whole outcome distribution and by use of antihypertensive drugs, age, and BP parameter evaluated. Misclassification for exposure and outcome variables should be considered in analyses of this topic.

  10. Different methods of calculating ankle-brachial index in mid-elderly men and women: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Miname, M; Bensenor, I M; Lotufo, P A

    2016-01-01

    The ankle-brachial index (ABI) is a marker of subclinical atherosclerosis related to health-adverse outcomes. ABI is inexpensive compared to other indexes, such as coronary calcium score and determination of carotid artery intima-media thickness (IMT). Our objective was to identify how the ABI can be applied to primary care. Three different methods of calculating the ABI were compared among 13,921 men and women aged 35 to 74 years who were free of cardiovascular diseases and enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The ABI ratio had the same denominator for the three categories created (the highest value for arm systolic blood pressure), and the numerator was based on the four readings for leg systolic blood pressure: the highest (ABI-HIGH), the mean (ABI-MEAN), and the lowest (ABI-LOW). The cut-off for analysis was ABI<1.0. All determinations of blood pressure were done with an oscillometric device. The prevalence of ABI<1% was 0.5, 0.9, and 2.7 for the categories HIGH, MEAN and LOW, respectively. All methods were associated with a high burden of cardiovascular risk factors. The association with IMT was stronger for ABI-HIGH than for the other categories. The proportion of participants with a 10-year Framingham Risk Score of coronary heart disease >20% without the inclusion of ABI<1.0 was 4.9%. For ABI-HIGH, ABI-MEAN and ABI-LOW, the increase in percentage points was 0.3, 0.7, and 2.3%, respectively, and the relative increment was 6.1, 14.3, and 46.9%. In conclusion, all methods were acceptable, but ABI-LOW was more suitable for prevention purposes.

  11. Thyrotropin levels are associated with chronic kidney disease among healthy subjects in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Peixoto de Miranda, Érique José F; Bittencourt, Márcio Sommer; Goulart, Alessandra C; Santos, Itamar S; de Oliveira Titan, Silvia Maria; Ladeira, Roberto Marini; Barreto, Sandhi Maria; Lotufo, Paulo A; Benseñor, Isabela Judith Martins

    2017-03-27

    Few studies have evaluated a possible relationship between thyrotropin levels and glomerular filtration rate (GFR) and albumin/creatinine ratio in euthyroid subjects. We aimed to analyze this association using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cross-sectionally, we included subjects with normal thyroid function and with subclinical hypothyroidism (SCH). We excluded individuals using medications that affect thyroid function. Linear and logistic regression models evaluated GFR estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) and albuminuria/creatinine ratio as dependent variables and thyrotropin quartiles in individuals with euthyroidism and SCH as independent variables, adjusted for demographical characteristics and diseases related to CKD. We included 13,193 subjects with a median age of 51 years [interquartile range, (IQR): 45-58], 6840 (51.8%) women, 12,416 (94.1%) euthyroid, and 777 (5.9%) with SCH. SCH subjects were characterized by higher age, triglycerides, frequency of white race, cardiovascular disease, CKD, and former smokers. In adjusted models, log-transformed TSH in euthyroid subjects was inversely and strongly associated with CKD (β = -2.181, 95% CI -2.714 to -1.648), P < 0.0001 for glomerular filtration rate and 4.528 (1.190-7.865) for albuminuria/creatinine ratio. Multivariate logistic models for euthyroid subjects showed an OR of 1.45 (95% CI 1.15-1.83) for GFR and of 1.95 (95% CI 1.08-3.54) for albuminuria/creatinine ratio in the fourth quartile of TSH using the first as the reference. Thyrotropin levels are independently associated with CKD in euthyroid subjects.

  12. Thyrotrophin levels and coronary artery calcification: Cross-sectional results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Peixoto de Miranda, Érique José F; Bittencourt, Márcio Sommer; Staniak, Henrique Lane; Pereira, Alexandre C; Foppa, Murilo; Santos, Itamar S; Lotufo, Paulo A; Benseñor, Isabela M

    2017-06-13

    There is little information about the association between thyrotrophin (TSH) levels and coronary artery calcification (CAC). Our aim was to analyse the association between TSH quintiles and subclinical atherosclerosis measured by CAC, using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cross-sectional study. We excluded individuals using medications that affect thyroid function and who self-reported cardiovascular disease. We included euthyroid subjects and individuals with subclinical hypothyroidism (SCHypo) and subclinical hyperthyroidism (SCHyper). Logistic regression models evaluated CAC >100 Agatston units as the dependent variable, and increasing quintiles of TSH as the independent variable, adjusted for demographic and cardiovascular risk factors. Our sample included 3836 subjects, mean age 49 years (interquartile range 44-56); 1999 (52.1%) were female, 3551 (92.6%) were euthyroid, 239 (6.2%) had SCHypo and 46 (1.2%) had SCHyper. The frequency of women, White people and never smokers as well as body mass index and insulin resistance increased according to quintiles. The 1st quintile for TSH (0-0.99 mIU/L) was associated with CAC >100, using the 3rd quintile (1.39-1.85 mIU/L) as reference (adjusted OR=1.57, 95% CI: 1.05-2.35, P=.027), but no association was shown for the 5th quintile (2.68-35.5 mIU/L) compared to the 3rd. Restricting the analysis to euthyroid subjects did not change the results. For women, but not for men, we observed a U-shaped curve with 1st and 5th TSH quintiles associated with CAC>100. Low and low-normal (1st quintile) TSH levels were associated with CAC>100 Agatston units in a sample with subclinical thyroid disorders and euthyroid subjects. © 2017 John Wiley & Sons Ltd.

  13. Age at first childbirth and newly diagnosed diabetes among postmenopausal women: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Yarmolinsky, James; Duncan, Bruce Bartholow; Barreto, Sandhi Maria; Diniz, Maria de Fátima Sander; Chor, Dora; Schmidt, Maria Inês

    2017-01-01

    It has been reported that earlier age at first childbirth may increase the risk of adult-onset diabetes among postmenopausal women, a novel finding with important public health implications. To date, however, no known studies have attempted to replicate this finding. We aimed to test the hypothesis that age at first childbirth is associated with the risk of adult-onset diabetes among postmenopausal women. Cross-sectional analysis using baseline data from 2919 middle-aged and elderly postmenopausal women in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Age at first childbirth was determined from self-reporting and newly diagnosed diabetes through a 2-hour 75-g oral glucose tolerance test and/or glycated hemoglobin. Logistic regression was performed to examine associations between age at first childbirth and newly diagnosed diabetes among postmenopausal women. We did not find any association between age at first childbirth and diabetes, either when minimally adjusted for age, race and study center (odds ratio, OR [95% confidence interval, CI]: ≤ 19 years: 1.15 [0.82-1.59], 20-24 years: 0.90 [0.66-1.23] and ≥ 30 years: 0.86 [0.63-1.17] versus 25-29 years; P = 0.36) or when fully adjusted for childhood and adult factors (OR [95% CI]: ≤ 19 years: 0.95 [0.67-1.34], 20-24 years: 0.78 [0.56-1.07] and ≥ 30 years: 0.84 [0.61-1.16] versus 25-29 years; P = 0.40). Our current analysis does not support the existence of an association between age at first childbirth and adult-onset diabetes among postmenopausal women, which had been reported previously.

  14. Insulin resistance is associated with carotid intima-media thickness in non-diabetic subjects. A cross-sectional analysis of the ELSA-Brasil cohort baseline.

    PubMed

    Santos, Itamar S; Bittencourt, Márcio S; Goulart, Alessandra C; Schmidt, Maria Inês; Diniz, Maria de Fátima H S; Lotufo, Paulo A; Benseñor, Isabela M

    2017-05-01

    Epidemiological studies have analyzed the association between carotid intima-media thickness (CIMT) and insulin resistance, glucose levels or glycated hemoglobin with mixed results. We aimed to evaluate the association between CIMT and homeostasis model assessment - insulin resistance (HOMA-IR), fasting and post-load plasma glucose and glycated hemoglobin in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline. We included 8028 participants (aged 35-74 years) without diabetes or overt cardiovascular disease who had complete CIMT data at baseline. We built crude and adjusted linear and binary logistic models to evaluate the association between CIMT and (a) HOMA-IR; (b) fasting plasma glucose; (c) post-load plasma glucose; and (d) glycated hemoglobin. We also built post-hoc models, stratified by sex. In the fully-adjusted linear models, only the association between CIMT (in mm) and HOMA-IR remained significant (β = 0.004; 95% confidence interval [95%CI]:0.001 to 0.006). Consistent with these results, only the association between the highest age- sex- and race-specific CIMT quartile and HOMA-IR was significant in the adjusted logistic model (odds ratio [OR]:1.10; 95% CI:1.04-1.17). The association between HOMA-IR and the highest CIMT quartile remained significant in sex-specific analyses (OR:1.10; 95% CI:1.02-1.20 for men and OR:1.10; 95% CI:1.02-1.20 for women). We did not find an independent association between CIMT and glucose or glycated hemoglobin. We found a direct association between HOMA-IR and CIMT in a large sample of non-diabetic participants. Mechanisms unrelated to glucose homeostasis, as a direct effect of insulin on atherosclerosis, or medial hypertrophy, may be involved. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    2014-01-01

    Objectives Early menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have different life courses, is unknown. We tested the hypothesis that earlier menarche is associated with higher diabetes risk in Brazilian adults. Methods We used data from 8,075 women aged 35-74 years in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who had complete information on age at menarche, diabetes status, and covariates. Diabetes was defined based on self-reported physician diagnosis, medication use, and laboratory variables (fasting glucose, 2-hour glucose, and glycated hemoglobin). Poisson regression was used to generate risk ratios (RR) and 95% confidence intervals (CI). Results Menarche onset < 11 years [vs. 13-14 years (referent)] was associated with higher risk of diabetes (RR = 1.34; 95% CI: 1.14-1.57) after adjusting for sociodemographic factors, maternal education, maternal and paternal diabetes, and birth weight. This persisted after further control for BMI at age 20 years and relative leg length. Additionally, among those not taking diabetes medications, earlier menarche [<11 years vs. 13-14 years (referent)] was associated with higher % glycated hemoglobin (p < 0.001), alanine aminotransferase (p < 0.001), triglycerides (p < 0.001), C-reactive protein (p = 0.003), waist circumference (p < 0.001), and BMI measured at baseline exam (p < 0.001). Conclusion These findings support the hypothesis that earlier menarche is associated with greater risk for adult diabetes and cardiometabolic disease in the Brazilian context. PMID:24438044

  16. Mortality risk attributable to smoking, hypertension and diabetes among English and Brazilian older adults (The ELSA and Bambui cohort ageing studies)

    PubMed Central

    Marmot, Michael G.; Demakakos, Panayotes; Vaz de Melo Mambrini, Juliana; Peixoto, Sérgio Viana; Lima-Costa, Maria Fernanda

    2016-01-01

    Background: The main aim of this study was to quantify and compare 6-year mortality risk attributable to smoking, hypertension and diabetes among English and Brazilian older adults. This study represents a rare opportunity to approach the subject in two different social and economic contexts. Methods: Data from the data from the English Longitudinal Study of Ageing (ELSA) and the Bambuí Cohort Study of Ageing (Brazil) were used. Deaths in both cohorts were identified through mortality registers. Risk factors considered in this study were baseline smoking, hypertension and diabetes mellitus. Both age–sex adjusted hazard ratios and population attributable risks (PAR) of all-cause mortality and their 95% confidence intervals for the association between risk factors and mortality were estimated using Cox proportional hazards models. Results: Participants were 3205 English and 1382 Brazilians aged 60 years and over. First, Brazilians showed much higher absolute risk of mortality than English and this finding was consistent in all age, independently of sex. Second, as a rule, hazard ratios for mortality to smoking, hypertension and diabetes showed more similarities than differences between these two populations. Third, there was strong difference among English and Brazilians on attributable deaths to hypertension. Conclusions: The findings indicate that, despite of being in more recent transitions, the attributable deaths to one or more risk factors was twofold among Brazilians relative to the English. These findings call attention for the challenge imposed to health systems to prevent and treat non-communicable diseases, particularly in populations with low socioeconomic level. PMID:26666869

  17. Different methods of calculating ankle-brachial index in mid-elderly men and women: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    Miname, M.; Bensenor, I.M.; Lotufo, P.A.

    2016-01-01

    The ankle-brachial index (ABI) is a marker of subclinical atherosclerosis related to health-adverse outcomes. ABI is inexpensive compared to other indexes, such as coronary calcium score and determination of carotid artery intima-media thickness (IMT). Our objective was to identify how the ABI can be applied to primary care. Three different methods of calculating the ABI were compared among 13,921 men and women aged 35 to 74 years who were free of cardiovascular diseases and enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The ABI ratio had the same denominator for the three categories created (the highest value for arm systolic blood pressure), and the numerator was based on the four readings for leg systolic blood pressure: the highest (ABI-HIGH), the mean (ABI-MEAN), and the lowest (ABI-LOW). The cut-off for analysis was ABI<1.0. All determinations of blood pressure were done with an oscillometric device. The prevalence of ABI<1% was 0.5, 0.9, and 2.7 for the categories HIGH, MEAN and LOW, respectively. All methods were associated with a high burden of cardiovascular risk factors. The association with IMT was stronger for ABI-HIGH than for the other categories. The proportion of participants with a 10-year Framingham Risk Score of coronary heart disease >20% without the inclusion of ABI<1.0 was 4.9%. For ABI-HIGH, ABI-MEAN and ABI-LOW, the increase in percentage points was 0.3, 0.7, and 2.3%, respectively, and the relative increment was 6.1, 14.3, and 46.9%. In conclusion, all methods were acceptable, but ABI-LOW was more suitable for prevention purposes. PMID:27901176

  18. Ellis-van Creveld syndrome.

    PubMed

    Sasalawad, Shilpa S; Hugar, Shivayogi M; Poonacha, K S; Mallikarjuna, Rachappa

    2013-07-09

    Ellis-van Creveld (EvC) syndrome or chondroectodermal dysplasia is an autosomal recessive disorder with characteristic clinical manifestations. The four principal characteristics are chondrodysplasia, polydactyly, ectodermal dysplasia and congenital heart defects. Its incidence in the general population is low. The oral manifestations of EvC syndrome include both soft tissues and teeth, but the dental literature on the subject is scarce. The present case describes the constant and variable oral findings in these patients, which can be diagnosed at any age, even during pregnancy. The presence of a variety of oral manifestations, such as fusion of upper lip to the gingival margin, presence of multiple frenula, abnormally shaped and microdontic teeth and congenitally missing teeth requires multidisciplinary dental treatment, with consideration for the high incidence of cardiac defects in these patients.

  19. Comparison of a short version of the Food Frequency Questionnaire with its long version--a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Mannato, Livia Welter; Pereira, Taisa Sabrina Silva; Velasquez-Melendez, Gustavo; Cardoso, Letícia de Oliveira; Benseñor, Isabela Martins; Molina, Maria del Carmen Bisi

    2015-01-01

    The food frequency questionnaire (FFQ) is the preferred instrument for obtaining dietary information in epidemiological studies. A short form of the FFQ was compared with the original version that was used in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), and also with three 24-hour dietary recalls. Cross-sectional study carried out in six Brazilian state capitals. Multiple linear regression was used to reduce the original food and drink list of the FFQ, which had contained 114 food items. The frequency of consumption and nutritional composition of the foods were also taken into consideration. To assess the validity of the shortened FFQ, the energy and nutrients values of the 24-hour dietary recalls were deattenuated and log-transformed. The list of the FFQ of ELSA-Brasil was reduced to 76 food items. The intraclass correlation coefficients in the validation study ranged from 0.17 (selenium) to 0.66 (calcium). The number of items was reduced by 33%, while still maintaining relatively good capacity to measure energy and selected nutrients.

  20. Genetics Home Reference: van der Woude syndrome

    MedlinePlus

    ... Moretti-Ferreira D, Richieri-Costa A, Dixon MJ, Murray JC. Mutations in IRF6 cause Van der Woude ... PubMed Central Nopoulos P, Richman L, Andreasen N, Murray JC, Schutte B. Cognitive dysfunction in adults with ...

  1. Stirling Powered Van Program overview. Revision

    SciTech Connect

    Shaltens, R.K.

    1986-01-01

    The Stirling Powered Van Program (SPVP) is a multiyear, multiphase program to evaluate the automotive Stirling engine (ASE) in Air Force vans under realistic conditions. The objective of the SPVP is to have a manufacturer and end user(s) (i.e., on the path to commercializatin) of the second-generation Mod II ASE upon completion of the Automotive Stirling Engine Program in 1987. In order to meet this objective, the SPVP must establish Stirling performance, integrity, reliability, durability, and maintainability. This paper reviews the ASE Program background leading to the Van Program and focuses on plans for evaluating the kinematic Stirling engine in Air Force vans. Also discussed are the NASA technology transfers to industry that have been accomplished and those which are currently being developed.

  2. Flower Still Life, Maria Van Oosterwijck

    ERIC Educational Resources Information Center

    Holtrop, Emily

    2004-01-01

    This brief article describes the life of Maria van Oosterwijck. It also discusses her art and its significance and symbolism. A list of suggested activities for elementary, middle, and high school students is included.

  3. Flower Still Life, Maria Van Oosterwijck

    ERIC Educational Resources Information Center

    Holtrop, Emily

    2004-01-01

    This brief article describes the life of Maria van Oosterwijck. It also discusses her art and its significance and symbolism. A list of suggested activities for elementary, middle, and high school students is included.

  4. Nodal Statistics for the Van Vleck Polynomials

    NASA Astrophysics Data System (ADS)

    Bourget, Alain

    The Van Vleck polynomials naturally arise from the generalized Lamé equation as the polynomials of degree for which Eq. (1) has a polynomial solution of some degree k. In this paper, we compute the limiting distribution, as well as the limiting mean level spacings distribution of the zeros of any Van Vleck polynomial as N --> ∞.

  5. Clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype.

    PubMed

    Song, Jae-Hoon; Ko, Kwan Soo; Suh, Ji Yoeun; Oh, Won Sup; Kang, Cheol-In; Chung, Doo Ryeon; Peck, Kyong Ran; Lee, Nam Yong; Lee, Wee Gyo

    2008-04-01

    To investigate the clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype (VanD-vanA VRE). We tested in vitro and in vivo efficacies of teicoplanin against VanD-vanA VRE strains. Change in teicoplanin MICs was monitored during incubation with teicoplanin. In vitro and in vivo time-kill assay and survival analysis using a mouse peritonitis model were performed. Teicoplanin MICs of VanD-vanA VRE strains increased to 128 mg/L within 48 h when they were cultured with 120 mg/L teicoplanin. In vitro and in vivo time-kill assay showed that VanD-vanA VRE strains were not eliminated by 120 mg/L teicoplanin in contrast to vancomycin-susceptible E. faecium and VanD-vanB strains. The survival rate of mice infected with VanD-vanA VRE strains treated with teicoplanin was comparable with that of untreated mice. Data suggest that teicoplanin would fail in the treatment of VanD type VRE infections if the strains contained the vanA gene, which cannot be detected in the clinical microbiology laboratory.

  6. [Ellis van Creveld. Case report].

    PubMed

    Cruz-Perea, M; Luna, D; Ramírez-Cheyne, J; Saldarriaga Gil, W; Isaza, C

    2014-10-01

    Ellis-van Creveld (EVC) (OMIM # 225500) syndrome is a rare skeletal dysplasia disorder transmitted by autosomal recessive inheritance. The diagnosis is made based on phenotypic characteristics such as chondrodysplasia, heart defects and polydactyly. The prognosis depends mainly on the severity of the disease, diagnosis and comprehensive management of the condition. To describe a patient diagnosed with EVC syndrome. Newborn diagnosed with EVC syndrome who presented dysmorphic facies, shortened long bones, rhizomelic shortening, small hands, brachydactyly, single transverse palmar crease, postaxial polydactyly in the upper limbs, bilateral preaxial polysyndactyly in lower limbs and hypoplastic nails, complex heart defects and narrow thorax. The evolution was unfavorable; the patient died 8 weeks after birth from complications due to heart defects. EVC syndrome is rare and unknown; therefore, it is important to spread its characteristics within the pediatric community, emphasizing that it affects multiple organ systems and requires a multidisciplinary approach to treat individually each patient, to provide genetic and reproductive counseling to couples and to give information regarding child development expectations.

  7. Van Allen Discovery Most Important

    NASA Technical Reports Server (NTRS)

    Jastrow, R.

    1959-01-01

    The first step toward the exploration of space occurred approximately 22 months ago as a part of the International Geophysical Year. In the short interval since October, 1957, the new tools of research, the satellite and the space rocket, have produced two unexpected results of fundamental scientific importance. First, instruments placed in the Explorer satellites by James A. Van Allen have revealed the existence of layers of energetic particles in the outer atmosphere. This discovery constitutes the most significant research achievement of the IGY satellite program. The layers may provide the explanation for the aurora and other geophysical phenomena, and they will also influence the design of vehicles for manned space flight, whose occupants must be shielded against their harmful biological effects. Second, the shape of the earth has been determined very accurately with the aid of data from the first Vanguard. As a result of this investigation, we have found that our planet tends toward the shape of a pear, with its stem at the North Pole. This discovery may produce major changes in our ideas on the interior structure of the earth.

  8. Competition between VanU(G) repressor and VanR(G) activator leads to rheostatic control of vanG vancomycin resistance operon expression.

    PubMed

    Depardieu, Florence; Mejean, Vincent; Courvalin, Patrice

    2015-04-01

    Enterococcus faecalis BM4518 is resistant to vancomycin by synthesis of peptidoglycan precursors ending in D-alanyl-D-serine. In the chromosomal vanG locus, transcription of the resistance genes from the PYG resistance promoter is inducible and, upstream from these genes, there is an unusual three-component regulatory system encoded by the vanURS(G) operon from the P(UG) regulatory promoter. In contrast to the other van operons in enterococci, the vanG operon possesses the additional vanU(G) gene which encodes a transcriptional regulator whose role remains unknown. We show by DNase I footprinting, RT-qPCR, and reporter proteins activities that VanU(G), but not VanR(G), binds to P(UG) and negatively autoregulates the vanURS(G) operon and that it also represses PYG where it overlaps with VanR(G) for binding. In clinical isolate BM4518, the transcription level of the resistance genes was dependent on vancomycin concentration whereas, in a ΔvanUG mutant, resistance was expressed at a maximum level even at low concentrations of the inducer. The binding competition between VanU(G) and VanR(G) on the P(YG) resistance promoter allowed rheostatic activation of the resistance operon depending likely on the level of VanR(G) phosphorylation by the VanS(G) sensor. In addition, there was cross-talk between VanS(G) and VanR'(G), a VanR(G) homolog, encoded elsewhere in the chromosome indicating a sophisticated and subtle regulation of vancomycin resistance expression by a complex two-component system.

  9. Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil)

    PubMed Central

    Yarmolinsky, James; Mueller, Noel T.; Duncan, Bruce B.; Bisi Molina, Maria del Carmen; Goulart, Alessandra C.; Schmidt, Maria Inês

    2015-01-01

    Introduction Observational studies have reported fairly consistent inverse associations between coffee consumption and risk of type 2 diabetes, but this association has been little investigated with regard to lesser degrees of hyperglycemia and other alterations in glucose homeostasis. Additionally, the association between coffee consumption and diabetes has been rarely investigated in South American populations. We examined the cross-sectional relationships of coffee intake with newly diagnosed diabetes and measures of glucose homeostasis, insulin sensitivity, and insulin secretion, in a large Brazilian cohort of middle-aged and elderly individuals. Methods We used baseline data from 12,586 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). Logistic regression analyses were performed to examine associations between coffee consumption and newly diagnosed diabetes. Analysis of covariance was used to assess coffee intake in relation to two-hour glucose from an oral glucose tolerance test, fasting glucose, glycated hemoglobin, fasting and –2-hour postload insulin and measures of insulin sensitivity. Results We found an inverse association between coffee consumption and newly diagnosed diabetes, after adjusting for multiple covariates [23% and 26% lower odds of diabetes for those consuming coffee 2–3 and >3 times per day, respectively, compared to those reporting never or almost never consuming coffee, (p = .02)]. An inverse association was also found for 2-hour postload glucose [Never/almost never: 7.57 mmol/L, ≤1 time/day: 7.48 mmol/L, 2-3 times/day: 7.22 mmol/L, >3 times/day: 7.12 mol/L, p<0.0001] but not with fasting glucose concentrations (p = 0.07). Coffee was additionally associated with 2-hour postload insulin [Never/almost never: 287.2 pmol/L, ≤1 time/day: 280.1 pmol/L, 2–3 times/day: 275.3 pmol/L, >3 times/day: 262.2 pmol/L, p = 0.0005) but not with fasting insulin concentrations (p = .58). Conclusion Our present study provides

  10. Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Yarmolinsky, James; Mueller, Noel T; Duncan, Bruce B; Bisi Molina, Maria Del Carmen; Goulart, Alessandra C; Schmidt, Maria Inês

    2015-01-01

    Observational studies have reported fairly consistent inverse associations between coffee consumption and risk of type 2 diabetes, but this association has been little investigated with regard to lesser degrees of hyperglycemia and other alterations in glucose homeostasis. Additionally, the association between coffee consumption and diabetes has been rarely investigated in South American populations. We examined the cross-sectional relationships of coffee intake with newly diagnosed diabetes and measures of glucose homeostasis, insulin sensitivity, and insulin secretion, in a large Brazilian cohort of middle-aged and elderly individuals. We used baseline data from 12,586 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). Logistic regression analyses were performed to examine associations between coffee consumption and newly diagnosed diabetes. Analysis of covariance was used to assess coffee intake in relation to two-hour glucose from an oral glucose tolerance test, fasting glucose, glycated hemoglobin, fasting and -2-hour postload insulin and measures of insulin sensitivity. We found an inverse association between coffee consumption and newly diagnosed diabetes, after adjusting for multiple covariates [23% and 26% lower odds of diabetes for those consuming coffee 2-3 and >3 times per day, respectively, compared to those reporting never or almost never consuming coffee, (p = .02)]. An inverse association was also found for 2-hour postload glucose [Never/almost never: 7.57 mmol/L, ≤1 time/day: 7.48 mmol/L, 2-3 times/day: 7.22 mmol/L, >3 times/day: 7.12 mol/L, p<0.0001] but not with fasting glucose concentrations (p = 0.07). Coffee was additionally associated with 2-hour postload insulin [Never/almost never: 287.2 pmol/L, ≤1 time/day: 280.1 pmol/L, 2-3 times/day: 275.3 pmol/L, >3 times/day: 262.2 pmol/L, p = 0.0005) but not with fasting insulin concentrations (p = .58). Our present study provides further evidence of a protective effect of

  11. Association between carotid intima-media thickness and adiponectin in participants without diabetes or cardiovascular disease of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    de Almeida-Pititto, Bianca; Ribeiro-Filho, Fernando Flexa; Santos, Itamar S; Lotufo, Paulo A; Bensenor, Isabela M; Ferreira, Sandra Rg

    2017-01-01

    Objective The study assessed the association of adiponectin concentration with carotid intima-media thickness (CIMT) in middle-aged participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. Design Cross-sectional analyses. Methods A sample of 687 individuals (35-54 years old) without diabetes or cardiovascular disease was stratified into two categories according to CIMT (< or ≥ 75th percentile). Traditional risk factors, C-reactive protein and adiponectin values were compared between categories by Student's t-test and frequencies by chi-square test. In linear regression models, associations of CIMT with adiponectin, adjusted for adiposity, blood pressure, C-reactive protein and homeostasis model assessment-insulin resistance were tested. Mean CIMT values were compared across quartiles of adiponectin concentrations using analysis of variance. Results Three hundred and forty-one individuals (49.6%) were women and 130 (19.0%) had three traditional cardiovascular risk factors. Those with elevated CIMT (21.8%) had greater mean values of body mass index (26.2(3.8) vs. 27.7(4.0)kg/m(2), p < 0.001), waist circumference (86.9(10.1) vs. 90.1(10.8) cm, p = 0.001), systolic blood pressure (116.2(13.6) vs.121.2(16.1) mmHg, p < 0.001), homeostasis model assessment index (1.4(0.9-2.4) vs. 1.8(1.1-2.9), p = 0.011), C-reactive protein (1.2 (0.6-2.6) vs. 1.4(0.8-3.2) mg/l, p = 0.054) and adiponectin (9.9 (6.0-14.7) vs. 8.9 (5.3-13.8) µg/ml, p = 0.002) levels than the counterpart, while plasma glucose and lipids were not different between groups. In the adjusted model, blood pressure (directly) and adiponectin (inversely) persisted associated with high CIMT. Mean CIMT was greater in the first quartile of adiponectin when compared with the other three quartiles ( p = 0.019). Conclusions Lower adiponectin levels together with higher blood pressure were independently associated with

  12. Ellis-Van Creveld syndrome

    PubMed Central

    Baujat, Geneviève; Le Merrer, Martine

    2007-01-01

    Ellis-van Creveld syndrome (EVC) is a chondral and ectodermal dysplasia characterized by short ribs, polydactyly, growth retardation, and ectodermal and heart defects. It is a rare disease with approximately 150 cases reported worldwide. The exact prevalence is unknown, but the syndrome seems more common among the Amish community. Prenatal abnormalities (that may be detected by ultrasound examination) include narrow thorax, shortening of long bones, hexadactyly and cardiac defects. After birth, cardinal features are short stature, short ribs, polydactyly, and dysplastic fingernails and teeth. Heart defects, especially abnormalities of atrial septation, occur in about 60% of cases. Cognitive and motor development is normal. This rare condition is inherited as an autosomal recessive trait with variable expression. Mutations of the EVC1 and EVC2 genes, located in a head to head configuration on chromosome 4p16, have been identified as causative. EVC belongs to the short rib-polydactyly group (SRP) and these SRPs, especially type III (Verma-Naumoff syndrome), are discussed in the prenatal differential diagnosis. Postnatally, the essential differential diagnoses include Jeune dystrophy, McKusick-Kaufman syndrome and Weyers syndrome. The management of EVC is multidisciplinary. Management during the neonatal period is mostly symptomatic, involving treatment of the respiratory distress due to narrow chest and heart failure. Orthopedic follow-up is required to manage the bones deformities. Professional dental care should be considered for management of the oral manifestations. Prognosis is linked to the respiratory difficulties in the first months of life due to thoracic narrowness and possible heart defects. Prognosis of the final body height is difficult to predict. PMID:17547743

  13. Ellis-van Creveld syndrome.

    PubMed

    Baujat, Geneviève; Le Merrer, Martine

    2007-06-04

    Ellis-van Creveld syndrome (EVC) is a chondral and ectodermal dysplasia characterized by short ribs, polydactyly, growth retardation, and ectodermal and heart defects. It is a rare disease with approximately 150 cases reported worldwide. The exact prevalence is unknown, but the syndrome seems more common among the Amish community. Prenatal abnormalities (that may be detected by ultrasound examination) include narrow thorax, shortening of long bones, hexadactyly and cardiac defects. After birth, cardinal features are short stature, short ribs, polydactyly, and dysplastic fingernails and teeth. Heart defects, especially abnormalities of atrial septation, occur in about 60% of cases. Cognitive and motor development is normal. This rare condition is inherited as an autosomal recessive trait with variable expression. Mutations of the EVC1 and EVC2 genes, located in a head to head configuration on chromosome 4p16, have been identified as causative. EVC belongs to the short rib-polydactyly group (SRP) and these SRPs, especially type III (Verma-Naumoff syndrome), are discussed in the prenatal differential diagnosis. Postnatally, the essential differential diagnoses include Jeune dystrophy, McKusick-Kaufman syndrome and Weyers syndrome. The management of EVC is multidisciplinary. Management during the neonatal period is mostly symptomatic, involving treatment of the respiratory distress due to narrow chest and heart failure. Orthopedic follow-up is required to manage the bones deformities. Professional dental care should be considered for management of the oral manifestations. Prognosis is linked to the respiratory difficulties in the first months of life due to thoracic narrowness and possible heart defects. Prognosis of the final body height is difficult to predict.

  14. Implementation of Linus Programme Based on the Model of Van Meter and Van Horn

    ERIC Educational Resources Information Center

    Sani, Nazariyah bt; Idris, Abdul Rahman

    2013-01-01

    The purpose of this study is to identify the understanding of school leaders on the implementation of LINUS programme that based on the features contained in the Implementation Model of Van Meter and Van Horn (1975). The study was carried out in the form of qualitative method and particularly, the multiple case studies that were conducted in four…

  15. English Translation of Selected Writings of Dina van Hiele-Geldof and Pierre M. van Hiele.

    ERIC Educational Resources Information Center

    Fuys, David, Ed.; And Others

    After observing secondary school students having great difficulty learning geometry in their classes, Dutch educators Pierre van Hiele and Dina van Hiele-Geldof developed a theoretical model involving five levels of thought development in geometry. It is the purpose of this monograph to present English translations of some significant works of the…

  16. The illness of Vincent van Gogh.

    PubMed

    Blumer, Dietrich

    2002-04-01

    Vincent van Gogh (1853-1890) had an eccentric personality and unstable moods, suffered from recurrent psychotic episodes during the last 2 years of his extraordinary life, and committed suicide at the age of 37. Despite limited evidence, well over 150 physicians have ventured a perplexing variety of diagnoses of his illness. Henri Gastaut, in a study of the artist's life and medical history published in 1956, identified van Gogh's major illness during the last 2 years of his life as temporal lobe epilepsy precipitated by the use of absinthe in the presence of an early limbic lesion. In essence, Gastaut confirmed the diagnosis originally made by the French physicians who had treated van Gogh. However, van Gogh had earlier suffered two distinct episodes of reactive depression, and there are clearly bipolar aspects to his history. Both episodes of depression were followed by sustained periods of increasingly high energy and enthusiasm, first as an evangelist and then as an artist. The highlights of van Gogh's life and letters are reviewed and discussed in an effort toward better understanding of the complexity of his illness.

  17. Integrable extended van der Waals model

    NASA Astrophysics Data System (ADS)

    Giglio, Francesco; Landolfi, Giulio; Moro, Antonio

    2016-10-01

    Inspired by the recent developments in the study of the thermodynamics of van der Waals fluids via the theory of nonlinear conservation laws and the description of phase transitions in terms of classical (dissipative) shock waves, we propose a novel approach to the construction of multi-parameter generalisations of the van der Waals model. The theory of integrable nonlinear conservation laws still represents the inspiring framework. Starting from a macroscopic approach, a four parameter family of integrable extended van der Waals models is indeed constructed in such a way that the equation of state is a solution to an integrable nonlinear conservation law linearisable by a Cole-Hopf transformation. This family is further specified by the request that, in regime of high temperature, far from the critical region, the extended model reproduces asymptotically the standard van der Waals equation of state. We provide a detailed comparison of our extended model with two notable empirical models such as Peng-Robinson and Soave's modification of the Redlich-Kwong equations of state. We show that our extended van der Waals equation of state is compatible with both empirical models for a suitable choice of the free parameters and can be viewed as a master interpolating equation. The present approach also suggests that further generalisations can be obtained by including the class of dispersive and viscous-dispersive nonlinear conservation laws and could lead to a new type of thermodynamic phase transitions associated to nonclassical and dispersive shock waves.

  18. The illness of Vincent van Gogh.

    PubMed

    Arnold, Wilfred Niels

    2004-03-01

    Vincent van Gogh (1853-1890) was a wonderfully accomplished artist whose work is now widely appreciated. He created a great number of masterpiece paintings and drawings in just one decade devoted to art. His productivity is even more remarkable when considered in the context of his debilitating illness. He suffered from medical crises that were devastating, but in the intervening periods he was both lucid and creative. He left a profound, soul-searching description of his jagged life in his correspondence, which provides the basis for the present analysis. An inherited metabolic disease, acute intermittent porphyria, accounts for all of the signs and symptoms of van Gogh's underlying illness. On this 150th anniversary of the birth of Vincent van Gogh it is appropriate to revisit the subject and to analyze the lack of organized skepticism in the popular media about other diagnoses.

  19. Social mobility and subclinical atherosclerosis in a middle-income country: Association of intra- and inter-generational social mobility with carotid intima-media thickness in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Guimarães, Joanna M N; Clarke, Philippa; Tate, Denise; Coeli, Claudia Medina; Griep, Rosane Harter; Fonseca, Maria de Jesus Mendes da; Santos, Itamar S; Melo, Enirtes Caetano Prates; Chor, Dora

    2016-11-01

    Over the past half century Brazil has undergone a process of dramatic industrialization and urbanization. Cardiovascular diseases (CVD) have become common due to rapid demographic, epidemiologic, and nutritional transitions. The association of social mobility with subclinical CVD has been rarely explored, particularly in developing societies. We investigated the association of intra- and inter-generational social mobility with carotid intima-media thickness (IMT), a marker of subclinical or asymptomatic atherosclerosis, in a large Brazilian sample (ELSA-Brasil). We used baseline data (2008-2010) for 7343 participants from ELSA-Brasil. Intra-generational social mobility was defined as the change in occupational social class between participants' first occupation and current occupation. Inter-generational social mobility was defined as the change in occupational social class of the head of the household when the participant started working and participants' current occupation. Social mobility groups were classified as: stable high (reference), upward, downward and stable low. Linear regression models were used to examine the associations between type of social mobility and IMT. Compared to those who experienced stable high occupational status across generations, downward inter-generational mobility was associated with greater IMT. Additionally, those who declined the most in occupational status had the highest values of IMT, even after adjustments for lifestyle and cardiovascular factors. For intra-generational mobility, stable low versus stable high social mobility was independently associated with higher IMT. Subclinical atherosclerosis is patterned by socioeconomic status both within and across generations, demonstrating an association even before symptoms of CVD appear. The health consequences of downward inter-generational social mobility were not fully explained by lifestyle and cardiovascular factors, whereas being consistently exposed to low occupational

  20. Efficient thermoelectric van der Pauw measurements

    NASA Astrophysics Data System (ADS)

    de Boor, Johannes; Schmidt, Volker

    2011-07-01

    The development of powerful thermoelectric materials requires fast and simple characterization techniques. We combine three measurements to obtain a complete thermoelectric characterization. The electrical conductivity is measured by the van der Pauw method, while ZT is determined directly by means of a Harman measurement. Finally, exploiting the analogy between electrical and thermal physics, a thermal van der Pauw measurement is performed and the sample Seebeck coefficient and thermal conductivity can be determined. No temperature differences need to be measured; all quantities can be deduced from voltage measurements concurrently on the same sample which allows for quick and convenient material screening.

  1. van der Waals radii of noble gases.

    PubMed

    Vogt, Jürgen; Alvarez, Santiago

    2014-09-02

    Consistent van der Waals radii are deduced for Ne-Xe, based on the noble gas···oxygen intermolecular distances found in gas phase structures. The set of radii proposed is shown to provide van der Waals distances for a wide variety of noble gas···element atom pairs that represent properly the distribution of distances both in the gas phase and in the solid state. Moreover, these radii show a smooth periodic trend down the group which is parallel to that shown by the halogens.

  2. Astronaut James van Hoften working with Syncom IV-3 satellite

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Astronaut James D. van Hoften, dwarfed by the large Syncom IV-3 satellite, moves in for initial contact. Dr. van Hoften stands on a foot restraint/extension to the remote manipulator system (RMS) arm.

  3. Tactisch Optreden van kleine eenheden (Small Unit Tactics)

    DTIC Science & Technology

    2007-08-01

    conform artikel Armex nr. 2 april 2005. Artikel: Landmacht september 2005. Afghanistan medio 2005. PRT verricht zijn werkzaamheden onder bescherming...battalion (SRF Bn). Artikel: Rinoceros medio 2005. Blad van de 13’ Painfbrig. Verhaal van soldaat I J. Kloek die op 29 juni 2005 het Kruis van...instanties/personen ontvangen een volledig exemplaar van bet rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie bijgeleverd op cd-rom 2/3 DMO/DR&D

  4. Van Gogh: a new Drosophila tissue polarity gene.

    PubMed

    Taylor, J; Abramova, N; Charlton, J; Adler, P N

    1998-09-01

    Mutations in the Van Gogh gene result in the altered polarity of adult Drosophila cuticular structures. On the wing, Van Gogh mutations cause an altered polarity pattern that is typical of mutations that inactivate the frizzled signaling/signal transduction pathway. The phenotype however, differs from those seen previously, as the number of wing cells forming more than one hair is intermediate between that seen previously for typical frizzled-like or inturned-like mutations. Consistent with Van Gogh being involved in the function of the frizzled signaling/signal transduction pathway, Van Gogh mutations show strong interactions with mutations in frizzled and prickle. Mitotic clones of Van Gogh display domineering cell nonautonomy. In contrast to frizzled clones, Van Gogh clones alter the polarity of cells proximal (and in part anterior and posterior) but not distal to the clone. In further contrast to frizzled clones, Van Gogh clones cause neighboring wild-type hairs to point away from rather than toward the clone. This anti-frizzled type of domineering nonautonomy and the strong genetic interactions seen between frizzled and Van Gogh suggested the possibility that Van Gogh was required for the noncell autonomous function of frizzled. As a test of this possibility we induced frizzled clones in a Van Gogh mutant background and Van Gogh clones in a frizzled mutant background. In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling.

  5. Van Gogh: a new Drosophila tissue polarity gene.

    PubMed Central

    Taylor, J; Abramova, N; Charlton, J; Adler, P N

    1998-01-01

    Mutations in the Van Gogh gene result in the altered polarity of adult Drosophila cuticular structures. On the wing, Van Gogh mutations cause an altered polarity pattern that is typical of mutations that inactivate the frizzled signaling/signal transduction pathway. The phenotype however, differs from those seen previously, as the number of wing cells forming more than one hair is intermediate between that seen previously for typical frizzled-like or inturned-like mutations. Consistent with Van Gogh being involved in the function of the frizzled signaling/signal transduction pathway, Van Gogh mutations show strong interactions with mutations in frizzled and prickle. Mitotic clones of Van Gogh display domineering cell nonautonomy. In contrast to frizzled clones, Van Gogh clones alter the polarity of cells proximal (and in part anterior and posterior) but not distal to the clone. In further contrast to frizzled clones, Van Gogh clones cause neighboring wild-type hairs to point away from rather than toward the clone. This anti-frizzled type of domineering nonautonomy and the strong genetic interactions seen between frizzled and Van Gogh suggested the possibility that Van Gogh was required for the noncell autonomous function of frizzled. As a test of this possibility we induced frizzled clones in a Van Gogh mutant background and Van Gogh clones in a frizzled mutant background. In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling. PMID:9725839

  6. Synthetic Minor NSR Permit: Van Hook Crude Terminal, LLC - Van Hook Crude Terminal/Rail Loading Facility

    EPA Pesticide Factsheets

    This page contains the current effective synthetic minor NSR permit for the Van Hook Crude Terminal, LLC, Van Hook Crude Terminal/Rail Loading Facility, located on the Fort Berthold Indian Reservation in Mountrail County, ND.

  7. Vincent van Gogh: The Postman Roulin.

    ERIC Educational Resources Information Center

    Miller, Stacy

    1989-01-01

    Provides a lesson plan for teaching K-three students to analyze and empathize with a portrait by post-impressionist painter Vincent van Gogh. Describes background of the artist and the painting "The Postman Roulin." Suggests instructional strategies, activities, and evaluation methods. Lists bibliographical material relative to van…

  8. Painting with Clay Van Gogh Style.

    ERIC Educational Resources Information Center

    Skophammer, Karen

    1999-01-01

    Discusses Vincent Van Gogh's painting "Starry Night" and describes a lesson where fifth- and sixth-grade students created their own version of the artwork. Explains that the students utilized four colors of Permoplast clay, using their hands and fingers as brushes and blending tools and the clay as paint. (CMK)

  9. Passenger Vans: A Transportation Concern for Camps.

    ERIC Educational Resources Information Center

    Gentle, Don; Gordon, Harold; Schainman, Steve

    2002-01-01

    In April 2002, the National Transportation Safety Board reissued a cautionary warning about the high accident potential of 15-passenger vans; some states have prohibited their use for transporting children. Three camp directors discuss legal and cost considerations for camps, possible alternative transportation, additional staff training needs,…

  10. The Forced van der Pol Equation

    ERIC Educational Resources Information Center

    Fay, Temple H.

    2009-01-01

    We report on a study of the forced van der Pol equation x + [epsilon](x[superscript 2] - 1)x + x = F cos[omega]t, by solving numerically the differential equation for a variety of values of the parameters [epsilon], F and [omega]. In doing so, many striking and interesting trajectories can be discovered and phenomena such as frequency entrainment,…

  11. Bernard van Leer Foundation Annual Report, 2000.

    ERIC Educational Resources Information Center

    Bernard Van Leer Foundation, The Hague (Netherlands).

    This annual report for 2000 describes the year's activities, achievements, and financial status of the Bernard van Leer Foundation, a private foundation based in The Netherlands that operates internationally to improve opportunities for young children from birth to age 7 living in circumstances of social and economic disadvantage. Following an…

  12. Bernard van Leer Foundation Annual Report, 2002.

    ERIC Educational Resources Information Center

    Bernard Van Leer Foundation, The Hague (Netherlands).

    This annual report for 2002 describes the year's activities, achievements, and financial status of the Bernard van Leer Foundation, a private foundation based in The Netherlands operating internationally to improve opportunities for young children from birth to age 7 living in circumstances of social and economic disadvantage. Following the…

  13. Note on a van der Waals Gas.

    ERIC Educational Resources Information Center

    Bauman, Robert P.; Harrison, Joseph G.

    1996-01-01

    Discusses the difficulties with the standard model for introduction of attractive forces into the van der Waals equation. Presents an analysis in terms of force and time delays and an alternative analysis for more advanced students in terms of energy. (JRH)

  14. Q & A with Carmella Van Vleet

    ERIC Educational Resources Information Center

    Curriculum Review, 2008

    2008-01-01

    This article presents an interview with Carmella Van Vleet, a former teacher and educational speaker. She has written family humor and parenting articles, and is also the author of "How to Handle School Snafus," "Great Ancient Egypt Projects You Can Build Yourself" and "Amazing Ben Franklin Inventions You Can Build Yourself." In this interview,…

  15. The van Gogh of the Infrared Sky

    NASA Image and Video Library

    2011-04-25

    NASA Wide-field Infrared Survey Explorer is a little like the Vincent van Gogh of the infrared sky, providing the world with picturesque images of the cosmos by representing infrared light through color. This image is the nebula NGC 2174.

  16. Interview with Joyce VanTassel-Baska.

    ERIC Educational Resources Information Center

    Olszewski-Kubilius, Paula

    2001-01-01

    This interview with Joyce VanTassel-Baska discusses the growth of talent search programs to identify highly gifted students via the Scholastic Aptitude Test and the role of computer technology in what can be offered to gifted students. Also identified are key characteristics of gifted elementary, middle, and secondary school programs. (CR)

  17. van Maanen, Adriaan (1884-1947)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Dutch astronomer, became a member of the Mount Wilson staff, and studied the rotation of spiral nebulae as a means to establish their distances. His detection of rotational motions was illusory and misleadingly suggested that they were relatively nearby. Through its proper motion and parallax, he discovered the white dwarf van Maanen's star....

  18. Q & A with Carmella Van Vleet

    ERIC Educational Resources Information Center

    Curriculum Review, 2008

    2008-01-01

    This article presents an interview with Carmella Van Vleet, a former teacher and educational speaker. She has written family humor and parenting articles, and is also the author of "How to Handle School Snafus," "Great Ancient Egypt Projects You Can Build Yourself" and "Amazing Ben Franklin Inventions You Can Build Yourself." In this interview,…

  19. Bernard van Leer Foundation Annual Report, 1999.

    ERIC Educational Resources Information Center

    Bernard Van Leer Foundation, The Hague (Netherlands).

    This annual report details the activities and financial status for 1999 of the Bernard van Leer Foundation, a private institution created in 1949 for broad humanitarian purposes. Following the introduction by the chairman of the Foundation's board of trustees, the report of the executive director details activities during the Foundation's fiftieth…

  20. Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

    PubMed Central

    Phillips-Jones, Mary K.; Channell, Guy; Kelsall, Claire J.; Hughes, Charlotte S.; Ashcroft, Alison E.; Patching, Simon G.; Dinu, Vlad; Gillis, Richard B.; Adams, Gary G.; Harding, Stephen E.

    2017-01-01

    VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been identified. Here we employ purified, intact and active VanSA membrane protein (henceforth referred to as VanS) in analytical ultracentrifugation experiments to study VanS oligomeric state and conformation in the absence and presence of vancomycin. A combination of sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge (SEDFIT, SEDFIT-MSTAR and MULTISIG analysis) showed that VanS in the absence of the ligand is almost entirely monomeric (molar mass M = 45.7 kDa) in dilute aqueous solution with a trace amount of high molar mass material (M ~ 200 kDa). The sedimentation coefficient s suggests the monomer adopts an extended conformation in aqueous solution with an equivalent aspect ratio of ~(12 ± 2). In the presence of vancomycin over a 33% increase in the sedimentation coefficient is observed with the appearance of additional higher s components, demonstrating an interaction, an observation consistent with our circular dichroism measurements. The two possible causes of this increase in s – either a ligand induced dimerization and/or compaction of the monomer are considered. PMID:28397853

  1. Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin.

    PubMed

    Phillips-Jones, Mary K; Channell, Guy; Kelsall, Claire J; Hughes, Charlotte S; Ashcroft, Alison E; Patching, Simon G; Dinu, Vlad; Gillis, Richard B; Adams, Gary G; Harding, Stephen E

    2017-04-11

    VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been identified. Here we employ purified, intact and active VanSA membrane protein (henceforth referred to as VanS) in analytical ultracentrifugation experiments to study VanS oligomeric state and conformation in the absence and presence of vancomycin. A combination of sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge (SEDFIT, SEDFIT-MSTAR and MULTISIG analysis) showed that VanS in the absence of the ligand is almost entirely monomeric (molar mass M = 45.7 kDa) in dilute aqueous solution with a trace amount of high molar mass material (M ~ 200 kDa). The sedimentation coefficient s suggests the monomer adopts an extended conformation in aqueous solution with an equivalent aspect ratio of ~(12 ± 2). In the presence of vancomycin over a 33% increase in the sedimentation coefficient is observed with the appearance of additional higher s components, demonstrating an interaction, an observation consistent with our circular dichroism measurements. The two possible causes of this increase in s - either a ligand induced dimerization and/or compaction of the monomer are considered.

  2. Evaluation of the Xpert vanA/vanB Assay Using Enriched Inoculated Broths for Direct Detection of vanB Vancomycin-Resistant Enterococci

    PubMed Central

    Arends, J. P.; Kampinga, G. A.; Ahmad, H. M.; Dijkhuizen, B.; van Barneveld, P.; Rossen, J. W. A.; Friedrich, A. W.

    2014-01-01

    Rapid and accurate detection of VRE (vancomycin-resistant enterococci) is required for adequate antimicrobial treatment and infection prevention measures. Previous studies using PCR for the detection of VRE, including Cepheid's Xpert vanA/vanB assay, reported accurate detection of vanA VRE; however, many false-positive results were found for vanB VRE. This is mainly due to nonenterococcal vanB genes, which can be found in the gut flora. Our goal was to optimize the rapid and accurate detection of vanB VRE and to improve the positive predictive value (PPV) by limiting false-positive results. We evaluated the use of the Xpert vanA/vanB assay on rectal swabs and on enriched inoculated broths for the detection of vanB VRE. By adjusting the cycle threshold (CT) cutoff value to ≤25 for positivity by PCR on enriched broths, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 96.9%, 100%, 100%, and 99.5% for vanB VRE, respectively. As shown in this study, CT values of ≤25 acquired from enriched broths can be considered true positive. For broths with CT values between 25 and 30, we recommend confirming the results by culture. CT values of >30 appeared to be true negative. In conclusion, this study shows that the Cepheid's Xpert vanA/vanB assay performed on enriched inoculated broths with an adjusted cutoff CT value is a useful and rapid tool for the detection of vanB VRE. PMID:25297325

  3. vanD and vanG-Like Gene Clusters in a Ruminococcus Species Isolated from Human Bowel Flora▿

    PubMed Central

    Domingo, M.-C.; Huletsky, A.; Giroux, R.; Picard, F. J.; Bergeron, M. G.

    2007-01-01

    A vancomycin-resistant, anaerobic, gram-positive coccus containing the vanD and vanG-like genes (strain CCRI-16110) was isolated from a human fecal specimen during a hospital surveillance program to detect carriers of vancomycin-resistant enterococci. Comparison of the 16S rRNA gene sequence of strain CCRI-16110 with databases revealed a potentially novel Ruminococcus species that was most similar (<94% identity) to Clostridium and Ruminococcus species. Strain CCRI-16110 was highly resistant to vancomycin and teicoplanin (MICs of >256 μg/ml). The complete DNA sequence of the vanD cluster was most similar (98.2% identity) to that of Enterococcus faecium BM4339, containing the vanD1 allele. An intD gene with 99% identity with that of this E. faecium strain was found to be associated with the vanD gene cluster of this novel anaerobic bacterium. Strain CCRI-16110 also harbors genes encoding putative VanSG, VanG, and VanTG proteins displaying 56, 73.6, and 55% amino acid sequence identity, respectively, compared to the corresponding proteins encoded by the vanG1 and vanG2 operons of Enterococcus faecalis BM4518 and N03-0233. This study reports for the first time an anaerobic bacterium containing the vanD gene cluster. This strain also harbors a partial vanG-like gene cluster. The presence of vanD- and vanG-containing anaerobic bacteria in the human bowel flora suggests that these bacteria may serve as a reservoir for the vanD and vanG vancomycin resistance genes. PMID:17724150

  4. Analysis of Adaptive Team Concept through Simulation Models: A Survey (toetsing van adaptieve teamconcepten door middel van simulatiemodellen: een verkenning)

    DTIC Science & Technology

    2006-02-01

    beschikt dat ondieptes kan vaststellen dan zou op basis van ’vaart en koers ’ de mogelijkheid van ’grounding’ kunnen worden vastgesteld. Op een...omgeving aanwezig zijn hun kenmerken, zoals: afstand, hoogte, snelheid, koers , radartype, verandering van gedrag, informatie die beschikbaar komt (wat

  5. An Exploratory Study of the Interpretation of Logical Operators in Database Querying (Een Verkennende Studie van de Interpretatie van Logische Operatoren bijhet Bevragen van een Database)

    DTIC Science & Technology

    1991-03-22

    nn i 3 CONTENTS Page SUMMARY 5 SAMENVATTING 6 1 INTRODUCTION 7 2 METHOD 11 2.1 Subjects 12 2.2 Stimuli 12 2.3 Procedure 14 3 RESULTS 15 3.1 Latency...SAMENVATITING Het gebruik van logische operatoren in vraagtalen wordt beschouwd als een belangrijke bron van gebruikersproblemen bij het bevragen van een...verwerkingscomponenten werden getest. 7 1 INTRODUCTION Database management systems (DBMSs) are now widely used for structuring and storing textual information in

  6. Thermal response in van der Waals heterostructures

    NASA Astrophysics Data System (ADS)

    Naidu Gandi, Appala; Alshareef, Husam N.; Schwingenschlögl, Udo

    2017-01-01

    We solve numerically the Boltzmann transport equations of the phonons and electrons to understand the thermoelectric response in heterostructures of M2CO2 (M: Ti, Zr, Hf) MXenes with transition metal dichalcogenide monolayers. Low frequency optical phonons are found to occur as a consequence of the van der Waals bonding, contribute significantly to the thermal transport, and compensate for the reduced contributions of the acoustic phonons (increased scattering cross-sections in heterostructures), such that the thermal conductivities turn out to be similar to those of the bare MXenes. Our results indicate that the important superlattice design approach of thermoelectrics (to reduce the thermal conductivity) may be effective for two-dimensional van der Waals materials when used in conjunction with intercalation.

  7. Thermal response in van der Waals heterostructures.

    PubMed

    Gandi, Appala Naidu; Alshareef, Husam N; Schwingenschlögl, Udo

    2017-01-25

    We solve numerically the Boltzmann transport equations of the phonons and electrons to understand the thermoelectric response in heterostructures of M2CO2 (M: Ti, Zr, Hf) MXenes with transition metal dichalcogenide monolayers. Low frequency optical phonons are found to occur as a consequence of the van der Waals bonding, contribute significantly to the thermal transport, and compensate for the reduced contributions of the acoustic phonons (increased scattering cross-sections in heterostructures), such that the thermal conductivities turn out to be similar to those of the bare MXenes. Our results indicate that the important superlattice design approach of thermoelectrics (to reduce the thermal conductivity) may be effective for two-dimensional van der Waals materials when used in conjunction with intercalation.

  8. [Psychiatric case history of Vincent van Gogh].

    PubMed

    van Meekeren, E

    2000-12-23

    Much has been written about Vincent van Gogh's pathological condition. Most authors base their various diagnoses on the symptoms he exhibited in the last years of his life. However, Van Gogh during a much longer part of his life displayed symptoms best consistent with a borderline (personality) disorder: impulsivity, variable moods, self-destructive behaviour, fear of abandonment, an unbalanced self-image, authority conflicts and other complicated relationships. The precipitating element disturbing Vincent's psychic balance--delicate in any case due to a positive family history, malnutrition, intoxication and exhaustion and the borderline disorder--may have been his being deserted by his friend Gauguin. He (also) developed an organic psychosyndrome with psychotic and epileptic elements. The stress (due to social isolation, by his being a psychiatric patient, and by poor prospects), the intoxication going on outside the hospitals and especially also the problems relating to his brother Theo caused a downward spiral culminating in suicide.

  9. Vincent van Gogh and the thujone connection.

    PubMed

    Arnold, W N

    1988-11-25

    During his last two years Vincent van Gogh experienced fits with hallucinations that have been attributed to a congenital psychosis. But the artist admitted to episodes of heavy drinking that were amply confirmed by colleagues and there is good evidence to indicate that addiction to absinthe exacerbated his illness. Absinthe was distilled from an alcoholic steep of herbs. Wormwood (Artemisia absinthium) was the most significant constituent because it contributed thujone. This terpene can cause excitation, convulsions that mimic epilepsy, and even permanent brain damage. Statements in van Gogh's letters and from his friends indicate that he had an affinity for substances with a chemical connection to thujone; the documented examples are camphor and pinene. Perhaps he developed an abnormal craving for terpenes, a sort of pica, that would explain his attempts to eat paints and so on, which were previously regarded as unrelated absurdities.

  10. Superlubricity using repulsive van der Waals forces.

    PubMed

    Feiler, Adam A; Bergström, Lennart; Rutland, Mark W

    2008-03-18

    Using colloid probe atomic force microscopy, we show that if repulsive van der Waals forces exist between two surfaces prior to their contact then friction is essentially precluded and supersliding is achieved. The friction measurements presented here are of the same order as the lowest ever recorded friction coefficients in liquid, though they are achieved by a completely different approach. A gold sphere attached to an AFM cantilever is forced to interact with a smooth Teflon surface (templated on mica). In cyclohexane, a repulsive van der Waals force is observed that diverges at short separations. The friction coefficient associated with this system is on the order of 0.0003. When the refractive index of the liquid is changed, the force can be tuned from repulsive to attractive and adhesive. The friction coefficient increases as the Hamaker constant becomes more positive and the divergent repulsive force, which prevents solid-solid contact, gets switched off.

  11. Van de Graaff Irradiation of Materials

    SciTech Connect

    Quigley, Kevin; Chemerisov, Sergey; Tkac, Peter; Vandegrift, George F.

    2016-10-01

    Through irradiations using our 3 MeV Van de Graaf accelerator, Argonne is testing the radiation stability of components of equipment that are being used to dispense molybdenum solutions for use as feeds to 99mTc generators and in the 99mTc generators themselves. Components have been irradiated by both a direct electron beam and photons generated from a tungsten convertor.

  12. Van de Graaff generator for capillary electrophoresis.

    PubMed

    Lee, Seung Jae; Castro, Eric R; Guijt, Rosanne M; Tarn, Mark D; Manz, Andreas

    2017-09-29

    A new approach for high voltage capillary electrophoresis (CE) is proposed, which replaces the standard high voltage power supply with a Van de Graaff generator, a low current power source. Because the Van de Graaff generator is a current-limited source (10μA), potentials exceeding 100kV can be generated for CE when the electrical resistance of the capillary is maximized. This was achieved by decreasing the capillary diameter and reducing the buffer ionic strength. Using 2mM borate buffer and a 5μm i.d. capillary, fluorescently labeled amino acids were separated with efficiencies up to 3.5 million plates; a 5.7 fold improvement in separation efficiency compared to a normal power supply (NPS) typically used in CE. This separation efficiency was realized using a simple set-up without significant Joule heating, making the Van de Graaff generator a promising alternative for applying the high potentials required for enhancing resolution in the separation and analysis of highly complex samples, for example mixtures of glycans. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Theory of coherent van der Waals matter.

    PubMed

    Kulić, Igor M; Kulić, Miodrag L

    2014-12-01

    We explain in depth the previously proposed theory of the coherent van der Waals (cvdW) interaction, the counterpart of van der Waals (vdW) force, emerging in spatially coherently fluctuating electromagnetic fields. We show that cvdW driven matter is dominated by many-body interactions, which are significantly stronger than those found in standard van der Waals (vdW) systems. Remarkably, the leading two- and three-body interactions are of the same order with respect to the distance (∝R(-6)), in contrast to the usually weak vdW three-body effects (∝R(-9)). From a microscopic theory we show that the anisotropic cvdW many-body interactions drive the formation of low-dimensional structures such as chains, membranes, and vesicles with very unusual, nonlocal properties. In particular, cvdW chains display a logarithmically growing stiffness with the chain length, while cvdW membranes have a bending modulus growing linearly with their size. We argue that the cvdW anisotropic many-body forces cause local cohesion but also a negative effective "surface tension." We conclude by deriving the equation of state for cvdW materials and propose experiments to test the theory, in particular the unusual three-body nature of cvdW.

  14. Xanthopsia and van Gogh's yellow palette.

    PubMed

    Arnold, W N; Loftus, L S

    1991-01-01

    A survey of van Gogh's work from 1886 to 1890 indicated that paintings with a yellow dominance were numerous, episodic, and multi-regional. His underlying illness, by his own admission, affected his life and work; furthermore, episodes of malnutrition, substance abuse, environmental exposure, and drug experimentation (all evident from correspondence) exacerbated his condition. Accordingly, we reviewed plausible agents that might have modified the artist's colour perception. Xanthopsia due to overdosage of digitalis or santonin is well documented elsewhere, but evidence of useage of either drug by van Gogh cannot be substantiated. It is unlikely that ageing of the human lens was an influence because of the artist's youth. Sunstroke is too restrictive to fit the multiplicity of regions and motifs. Hallucinations induced by absinthe, the popular liqueur of the period, may explain particular canvases but not the majority of 'high yellow' paintings. Van Gogh's proclivity for exaggerated colours and his embrance of yellow in particular are clear from his letters and, in contradistinction to chemical or physical insults modifying perception, artistic preference is the best working hypothesis to explain the yellow dominance in his palette.

  15. Theory of coherent van der Waals matter

    NASA Astrophysics Data System (ADS)

    Kulić, Igor M.; Kulić, Miodrag L.

    2014-12-01

    We explain in depth the previously proposed theory of the coherent van der Waals (cvdW) interaction, the counterpart of van der Waals (vdW) force, emerging in spatially coherently fluctuating electromagnetic fields. We show that cvdW driven matter is dominated by many-body interactions, which are significantly stronger than those found in standard van der Waals (vdW) systems. Remarkably, the leading two- and three-body interactions are of the same order with respect to the distance (∝R-6) , in contrast to the usually weak vdW three-body effects (∝R-9 ). From a microscopic theory we show that the anisotropic cvdW many-body interactions drive the formation of low-dimensional structures such as chains, membranes, and vesicles with very unusual, nonlocal properties. In particular, cvdW chains display a logarithmically growing stiffness with the chain length, while cvdW membranes have a bending modulus growing linearly with their size. We argue that the cvdW anisotropic many-body forces cause local cohesion but also a negative effective "surface tension." We conclude by deriving the equation of state for cvdW materials and propose experiments to test the theory, in particular the unusual three-body nature of cvdW.

  16. Members of the genera Paenibacillus and Rhodococcus harbor genes homologous to enterococcal glycopeptide resistance genes vanA and vanB.

    PubMed

    Guardabassi, L; Christensen, H; Hasman, H; Dalsgaard, A

    2004-12-01

    Genes homologous to enterococcal glycopeptide resistance genes vanA and vanB were found in glycopeptide-resistant Paenibacillus and Rhodococcus strains from soil. The putative D-Ala:D-Lac ligase genes in Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B were closely related to vanA (92 and 87%) and flanked by genes homologous to vanH and vanX in vanA operons.

  17. Members of the Genera Paenibacillus and Rhodococcus Harbor Genes Homologous to Enterococcal Glycopeptide Resistance Genes vanA and vanB

    PubMed Central

    Guardabassi, L.; Christensen, H.; Hasman, H.; Dalsgaard, A.

    2004-01-01

    Genes homologous to enterococcal glycopeptide resistance genes vanA and vanB were found in glycopeptide-resistant Paenibacillus and Rhodococcus strains from soil. The putative d-Ala:d-Lac ligase genes in Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B were closely related to vanA (92 and 87%) and flanked by genes homologous to vanH and vanX in vanA operons. PMID:15561881

  18. Diagnostic accuracy of the Cepheid GeneXpert vanA/vanB assay ver. 1.0 to detect the vanA and vanB vancomycin resistance genes in Enterococcus from perianal specimens.

    PubMed

    Marner, Erin S; Wolk, Donna M; Carr, Jeanne; Hewitt, Carolyn; Dominguez, Lorraine L; Kovacs, Thomas; Johnson, Desiree R; Hayden, Randall T

    2011-04-01

    Rapid detection of vancomycin-resistant enterococci (VRE) carriers could be useful to health care facilities to minimize transmission. To that end, we compared the performance of the Cepheid GeneXpert vanA/vanB assay with that of direct and broth-enriched culture methods for detection of VRE from perianal swabs. Enterococci were cultivated on Enterococcosel™ agar with 8 μg/mL vancomycin, Bile Esculin Azide Agar with 6 μg/mL vancomycin, and Bile Esculin Azide Enterococcosel Broth. Compared to the reference standard (combination of direct agar plating, broth-enriched culture, and clinical chart review), the sensitivity, specificity, positive predictive value, and negative predictive value of the vanA/vanB assay were 96.4%, 93.0%, 92.0%, and 96.9%, respectively (n=184). The 95% limit of detection was 100 colony-forming units (CFU)/mL for vanA and 114 CFU/mL for vanB. In summary, the GeneXpert vanA/vanB assay is a rapid and accurate method to identify vanA/vanB-colonized patients for VRE screening programs that use perianal swab specimens.

  19. A unique Austin Chalk reservoir, Van field, Van Zandt County, Texas

    SciTech Connect

    Lowe, J.T. )

    1990-09-01

    Significant shallow oil production from the Austin Chalk was established in the Van field, Van Zandt County, in East Texas in the late 1980s. The Van field structure is a complexly faulted domal anticline created by salt intrusion. The Woodbine sands, which underlie the Austin Chalk, have been and continue to be the predominant reservoir rocks in the field. Evidence indicates that faults provided vertical conduits for migration of Woodbine oil into the Austin Chalk where it was trapped along the structural crest. The most prolific Austin Chalk production is on the upthrown side of the main field fault, as is the Woodbine. The Austin Chalk is a soft, white to light gray limestone composed mostly of coccoliths with some pelecypods. Unlike the Austin Chalk in the Giddings and Pearsall fields, the chalk at Van was not as deeply buried and therefore did not become brittle and susceptible to tensional or cryptic fracturing. The shallow burial in the Van field was also important in that it allowed the chalk to retain primary microporosity. The production comes entirely from this primary porosity. In addition to the structural position and underlying oil source from the Woodbine, the depositional environment and associated lithofacies are also keys to the reservoir quality in the Van field as demonstrated by cores from the upthrown and downthrown (less productive) sides of the main field fault. It appears that at the time of Austin Chalk deposition, the main field fault was active and caused the upthrown side to be a structural high and a more agreeable environment for benthonic organisms such as pelecypods and worms. The resulting bioturbation enhanced the reservoir's permeability enough to allow migration and entrapment of the oil. Future success in exploration for analogous Austin Chalk reservoirs will require the combination of a favorable environment of deposition, a nearby Woodbine oil source, and a faulted trap that will provide the conduit for migration.

  20. [Drugs and poisons in the life of Vincent van Gogh].

    PubMed

    Berggren, L

    1997-01-01

    Van Gogh was during his last years exposed to several potentially toxic substances such as; bromides, lead, camphor and terpene oils in absinthe liquor. All of them produce signs of toxicity which are similar to the symptoms known from van Gogh's attacks of illness; hallucinations, confusion, delirium, convulsions and agitation. However, the many interpretations of van Gogh's illness and state of mind have in most cases not taken into account the possible influence of toxic chemicals.

  1. Militaire Toepassingen Van Adaptieve Optiek (Military Applications of Adaptive Optics)

    DTIC Science & Technology

    2006-09-01

    deze technologic laser- DIRCM-s ystemen gemaakt voor welke optieken en voor welke toekomst gebruiki gaan worden en dat de kan verbeteren. In dit...waarneembaar Geen beeld onscherpte door atmosferische turbulentie D > ro Cohoronte elgonschappon van bron gaan door sen middoling in do aportuur vertoron Goon...L is gevarieerd van 0. 1 tot 2.5 km. Als we voor deze geavanceerde optieken gebruik willen gaan maken van adaptieve optiek, dan moet ook nog bekeken

  2. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

    PubMed Central

    Arthur, M; Molinas, C; Courvalin, P

    1992-01-01

    Plasmid pIP816 of Enterococcus faecium BM4147 confers inducible resistance to vancomycin and encodes the VanH dehydrogenase and the VanA ligase for synthesis of depsipeptide-containing peptidoglycan precursors which bind the antibiotic with reduced affinity. We have characterized a cluster of five genes of pIP816 sufficient for peptidoglycan synthesis in the presence of vancomycin. The distal part of the van cluster encodes VanH, VanA, and a third enzyme, VanX, all of which are necessary for resistance. Synthesis of these enzymes was regulated at the transcriptional level by the VanS-VanR two-component regulatory system encoded by the proximal part of the cluster. VanR was a transcriptional activator related to response regulators of the OmpR subclass. VanS stimulated VanR-dependent transcription and was related to membrane-associated histidine protein kinases which control the level of phosphorylation of response regulators. Analysis of transcriptional fusions with a reporter gene and RNA mapping indicated that the VanR-VanS two-component regulatory system activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes. Images PMID:1556077

  3. Devices and applications of van der Waals heterostructures

    NASA Astrophysics Data System (ADS)

    Li, Chao; Zhou, Peng; Zhang, David Wei

    2017-03-01

    Van der Waals heterostructures, composed of individual two-dimensional material have been developing extremely fast. Synthesis of van der Waals heterostructures without the constraint of lattice matching and processing compatibility provides an ideal platform for fundamental research and new device exploitation. We review the approach of synthesis of van der Waals heterostructures, discuss the property of heterostructures and thoroughly illustrate the functional van der Waals heterostructures used in novel electronic and photoelectronic device. Project supported by the National Key Research and Development Program (No. 2016YFA0203900) and the National Natural Science Foundation of China (Nos. 61376093, 61622401).

  4. Work-family conflict, lack of time for personal care and leisure, and job strain in migraine: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Griep, Rosane Härter; Toivanen, Susanna; Santos, Itamar S; Rotenberg, Lucia; Juvanhol, Leidjaira Lopes; Goulart, Alessandra C; Aquino, Estela M; Benseñor, Isabela

    2016-11-01

    Work-family conflict and time scarcity may affect health. We investigated the association between these issues and migraine, taking into account job strain. Baseline data from ELSA-Brasil (6,183 women; 5,664 men) included four indicators of work-family conflict: time- and strain-based interference of work with family (TB-WFC, SB-WFC), interference of family with work (FWC) and lack of time for personal care and leisure (LOT). Migraine was classified according to International Headache Society criteria. Among women, definite migraine was associated with SB-WFC (odds ratio [OR] = 1.28; 95% confidence interval [CI] 1.06-1.55), FWC (OR = 1.32; 1.00-1.75), and LOT (OR = 1.30; 1.08-1.58). Probable migraine was associated with SB-WFC (OR = 1.17; 1.00-1.36). High psychological job demands and low social support interacted with LOT in association with definite migraine. Among men, probable migraine was associated with LOT (OR = 1.34; 1.09-1.64), and there were interactions between job strain and WFC for probable migraine. Balancing the demands of professional and domestic spheres could be highly relevant in the management of migraines. Am. J. Ind. Med. 59:987-1000, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  5. Van Kampen modes for bunch longitudinal motion

    SciTech Connect

    Burov, A.; /Fermilab

    2010-09-01

    Conditions for existence, uniqueness and stability of bunch steady states are considered. For the existence uniqueness problem, simple algebraic equations are derived, showing the result both for the action and Hamiltonian domain distributions. For the stability problem, van Kampen theory is used. Emerging of discrete van Kampen modes show either loss of Landau damping, or instability. This method can be applied for an arbitrary impedance, RF shape and beam distribution function Available areas on intensity-emittance plane are shown for resistive wall wake and single harmonic, bunch shortening and bunch lengthening RF configurations. Language of van Kampen modes is a powerful tool for studying beam stability. Its unique efficiency reveals itself in those complicated cases, when the dielectric function cannot be obtained, as it is for the longitudinal bunch motion. Emergence of a discrete mode means either loss of Landau damping or instability. By definition, the discrete modes lie outside the continuous incoherent spectrum, but they still may stay within the bucket. In the last case, the discrete mode would disappear after a tiny portion of resonant particles would be added. However, if the discrete mode lie outside the bucket, the Landau damping cannot be restored by tiny perturbation of the particle distribution; LLD is called radical in that case. For a given bunch emittance and RF voltage, the intensity is limited either by reduction of the bucket acceptance or by (radical) LLD. In this paper, results are presented for longitudinal bunch stability in weak head-tail approximation and resistive wall impedance; three RF configurations are studied: single harmonic, bunch shortening and bunch lengthening. It is shown that every RF configuration may be preferable, depending on the bunch emittance and intensity.

  6. van der Waals Heterostructures Grown by MBE

    NASA Astrophysics Data System (ADS)

    Hinkle, Christopher

    In this work, we demonstrate the high-quality MBE heterostructure growth of various layered 2D materials by van der Waals epitaxy (VDWE). The coupling of different types of van der Waals materials including transition metal dichalcogenide thin films (e.g., WSe2, WTe2, HfSe2) , insulating hexagonal boron nitride (h-BN), and topological insulators (e.g., Bi2Se3) allows for the fabrication of novel electronic devices that take advantage of unique quantum confinement and spin-based characteristics. The relaxed lattice-matching criteria of van der Waals epitaxy has allowed for high-quality heterostructure growth with atomically abrupt interfaces, allowing us to couple these materials based primarily on their band alignment and electronic properties. We will discuss the impact of sample preparation, surface reactivity, and lattice mismatch of various substrates (sapphire, graphene, TMDs, Bi2Se3) on the growth mode and quality of the films and will discuss our studies of substrate temperature and flux rates on the resultant growth and grain size. Structural and chemical characterization was conducted via reflection high energy electron diffraction (RHEED, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning tunneling microscopy/spectroscopy (STM/S), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Experimentally determined band alignments have been determined and compared with first-principles calculations allowing the design of novel low-power logic and magnetic memory devices. Initial results from the electrical characterization of these grown thin films and some simple devices will also be presented. These VDWE grown layered 2D materials show significant potential for fabricating novel heterostructures with tunable band alignments and magnetic properties for a variety of nanoelectronic and optoelectronic applications.

  7. [Johann van Beethoven (1776-1848)].

    PubMed

    Eikermann, Erika

    2012-01-01

    The article about the life and achievements of the apothecary Johann van Beethoven, the younger brother of the composer Ludwig van Beethoven, depicts a vivid picture of life in the 18th, 19t century. Research on archived original documents in Bonn, Vienna and Linz on the Danube made it possible to reveal details about the relationship inside this famous family and describes the hurdles of life of a successful apothecary. In 1776 Johann van Beethoven was born as the fourth child of the Beethoven family, a family of Bonner musicians. In 1790 he began his apprenticeship to become an apothecary at the Bonner "Hofapotheke". Towards the end of 1795 he moved to join his older brothers Ludwig and Karl in Vienna. During his time there he worked as a "subject" in various Viennese pharmacies. However in 1808 he purchased the pharmacy "Zur Goldenen Krone" in Linz on the Danube. His new pharmacy flourished, supplying first the Napoleonic occupation troops, and later the Austrian Military with medicines and field dressing/bandage materials. When in 1812 he married his Housekeeper, his Brother Ludwig opposed harshly, on reasons of social status and on moral grounds. Four years later, in 1816 Johann sold the pharmacy in Linz and founded a new pharmacy in Urfahr, on the opposite bank of the Danube. In 1819 he became a squire (or landowner), when he purchased a manor estate in Gneixendorf, near Krems on the Danube. In spite of his numerous duties as an apothecary and squire, Johann was frequently resident in Vienna, supporting his brother both emotionally and pharmaceutically. At the end of his life Johann sold both his pharmacy and the Gneixendorf estate, and spent his last years as a private gentleman living a dazzling lifestyle in Vienna. He died on January 12th 1848 and was buried in Vienna's "Waldmüllerpark".

  8. The microscopes of Antoni van Leeuwenhoek.

    PubMed

    van Zuylen, J

    1981-03-01

    The seventeenth-century Dutch microscopist, Antoni van Leeuwenhoek, was the first man to make a protracted study of microscopical objects, and, unlike his contemporary Robert Hooke, he viewed by transmitted light. Leeuwenhoek made over 500 of his own, curious, simple microscopes, but now only nine are known to exist. The exact nature of the lenses Leeuwenhoek made, has for long been a puzzle. The existing microscopes have now been examined in detail, and their optical characteristics measured and tabulated. It is proposed that the lens of highest magnification, x 266, was made using a special blown bubble technique.

  9. Interlayer Hybridization in van der Waals Heterostructures

    NASA Astrophysics Data System (ADS)

    Le, Nam; Tran, Huan; Woods, Lilia

    Van der Waals heterostructures composed of chemically inert dissimilar layers are of great interest for fundamental science and applications. The weak interplanar interactions and orbital overlap are expected to bring modifications to the constituent materials. By using first principles simulations, we investigate the properties of several heterostructures, including graphene/silicene, graphene/MoS2, and silicene/MoS2. The calculations reveal superlattice characteristic points in the Brillouin zone associated with the different stacking patterns. Band structures projected on each of the constituents show hybridization features related to specific orbital overlap for each heterostructure. Phonon dispersion spectra for the considered heterostructures are also investigated.

  10. Fundacion Bernard van Leer, Boletin Informativo, 1987-1996 (Bernard van Leer Foundation Information Bulletin).

    ERIC Educational Resources Information Center

    Fundacion Bernard van Leer, Boletin Informativo, 1996

    1996-01-01

    This document consists of ten annual Spanish Language Bulletins, published during the period 1987-1996. The early bulletins were largely composed of selections originally published in the Bernard van Lear Foundation's English-Language "Newsletter The articles discuss topics such as: (1) parents as children's first teachers; (2) health and…

  11. Bernard van Leer Foundation Annual Review 1993 = Fundacion Bernard van Leer Revista Anual 1993.

    ERIC Educational Resources Information Center

    Bernard Van Leer Foundation, The Hague (Netherlands).

    This report, in both English and Spanish versions, aims to highlight the Bernard van Leer Foundation's identity, objectives, and major activities, as well as the work undertaken by the projects the foundation supports. The review features articles on the Foundation's work on advocacy, supporting families living in disadvantaged circumstances,…

  12. Additional Value from Road Mapping in Defense Policy Making (meerwaarde van roadmapping bij beleidsontwikkeling van de koninklijke landmacht)

    DTIC Science & Technology

    2006-05-01

    diplomaat, woordvoerder ( media ) en manager zijn. Kuj dient in elke faso van eon oporatie met do media to kunnen communicoron an Commandant van do aan to...doel te richten. Hierbij kan gedacht worden aan politieke-, sociale -, humanitaire-, economische-, militaire- en financiele instrumenten. Door de...Hierbij kan gedacht worden aan politieke-, sociale -, humanitaire-, economisvhe-, militaire- en financi~le instrumenten. Door de ontwikkeling van NEC

  13. Ergonomische Evaluatie van Drie Prototypen van een Gevechtsbepak- Kingssysteem (Ergonomical Evaluation of Three Prototypes of a Military Backpack)

    DTIC Science & Technology

    1990-07-25

    M. Holewijn KINGSSYSTEEM (V) R. Heus . t d (’ JNiets uit daeze LIligave mag wre vermenlgvuldigd en/of openbaar gemaakt door middel van druk, fotoliople...met twos schouderbanden en is gemaakt van 6 Cordurn (Hp ]i.1A) . 0) doýý e henphand hey I nd t z iech tulltioW bhar d wnnrop melt schuifhiakezi de...tostonderdool word or eon significant vorschil. gevondon tussen hot pros tatiovorl ios (1) van do vrouweiijko on hot prostatie- verlios ( t ) van do

  14. [The psychiatric illness of Vincent van Gogh].

    PubMed

    Strik, W K

    1997-05-01

    Vincent van Gogh's illness has been the object of much speculation. Explanations as disparate as acute intermittent porphyria, epilepsy and schizophrenia have been proposed. Many of the diagnostic hypotheses, however, are based on partial or incomplete consideration of the biography and of the reports of his subjective experience in his letters to his brother. Karl Leonhard showed, in a detailed analysis of Vincent's biography, that both the course and symptoms of the disorder were consistent with the diagnosis of a cycloid psychosis (anxiety-elation psychosis). In the present paper, the diagnostic judgement of Leonhard is described and discussed in the light of independent research on van Gogh's letters, his works and biography. The bibliographical sources were investigated for information consistent with a cycloid psychosis, but also for information that might contradict this hypothesis. The course and symptoms of the disorder are presented as comprehensively and systematically as possible and are documented with the respective citations. Furthermore, the most important diagnoses proposed in the literature are critically discussed. Based on this investigation, it was possible to show that only the diagnosis of a cycloid psychosis allowed us to connect all the available information to a typical psychiatric syndrome.

  15. Vincent van Gogh: a pathographic analysis.

    PubMed

    Correa, R

    2014-02-01

    The life and artistic legacy of Vincent van Gogh has generated great interest among physicians from different areas of specialization in proposing a retrospective differential diagnosis. The aim of the present study is to present a systematic pathographic analysis of the artist and to suggest a diagnosis consistent with the extant evidence. To this end, the available evidence is classified into five types: type I evidence (clinical opinion of an attending physician), type II evidence (description of symptoms in correspondence), type III evidence (historical accounts from first-hand sources or direct observation), type IV evidence (interpretation of the artist's work) and type V evidence (family medical history). Three basic prerequisites for a successful analysis are: (1) consideration of type II, III and V evidence as carrying the greatest pathographic weight, (2) consideration of the course of symptoms over time as a key element in the analysis, and (3) consideration of a single diagnostic hypothesis as the most probable explanation. After reviewing the available evidence in the light of these criteria, the author supports the diagnosis of acute intermittent porphyria (AIP) as the most likely cause of van Gogh's ailment. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. [Acceptance of van Swieten's liquor in Japan].

    PubMed

    Takahashi, Fumi

    2002-12-01

    Carl Peter Thunberg, a Swedish medical doctor and botanist who visited Japan in 1775 as a medical doctor attached to the Dutch Trade House in Dejima, Nagasaki, taught the treatment of syphilis using mercury water to Japanese doctors and interpreters. This therapy is based on the oral administration of a 0.014% solution of mercuric chloride and was published in 1754 by Gerard van Swieten in Vienna, who questioned the utility of the conventional salivation therapy. The dose was set taking safety into account. Kogyu Yoshio, a Japanese-Dutch interpreter, had already read about it in a book written by J. J. Plenck, when he was taught about the therapy by Thunberg. He recorded Thunberg's teachings in his book "Komohijiki", presenting details of various formulations, including a high-dose formulation. The mercury therapy was subsequently spread across the country by medical doctors who learned Western medicine through the Dutch. In the 1820's, Genshin Udagawa, who read a number of Western medical books, published books on Western drugs. In these books, G. Udagawa included precise information on "Swieten Yakushu-hu (medicated alcohol)", including information on the dosage, formulation, mode of usage, and precautions for use. The maximum dose of mercuric chloride established chloride established by van Swieten was included in the Japanese Pharmacopoeia up to its 5th edition.

  17. United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)

    SciTech Connect

    Not Available

    2010-02-01

    This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

  18. 38 CFR 61.18 - Capital grants for vans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Capital grants for vans. 61.18 Section 61.18 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM Capital Grants § 61.18 Capital grants for vans....

  19. 38 CFR 61.18 - Capital grants for vans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Capital grants for vans. 61.18 Section 61.18 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM Capital Grants § 61.18 Capital grants for vans....

  20. Multiple Voices in Charles Van Riper's Desensitization Therapy

    ERIC Educational Resources Information Center

    Leahy, Margaret M.

    2008-01-01

    Background: Charles Van Riper (1905-94) author, researcher and practitioner, was one of the major contributors to the field of stuttering in the 20th century. His series of Action Therapy videotapes provide a useful model of how therapy was implemented by a master clinician. Aims: Van Riper's session with a client is analysed to reveal how voices…

  1. The Selection of a Van Lift or a Scooter.

    ERIC Educational Resources Information Center

    Stevens, John H.

    1990-01-01

    This newsletter issue describes 3-wheeled scooters and van lifts that can assist a person with a disability to drive independently or have access to transportation. The section on van lifts compares hydraulic lifts and electric lifts, lists manufacturers, and offers an "assessment quiz" outlining factors to consider in selecting a van…

  2. Correspondence of the Gardner and van Genuchten relativepermeability function parameters

    SciTech Connect

    Ghezzehei, Teamrat A.; Kneafsey, Timothy J.; Su, Grace W.

    2006-07-13

    The Gardner and van Genuchten models of relativepermeability are widely used in analytical and numerical solutions toflow problems. However, the applicability of the Gardner model to realproblems is usually limited, because empirical relative permeability datato calibrate the model are not routinely available. In contrast, vanGenuchten parameters can be estimated using more routinely availablematric potential and saturation data. However, the van Genuchten model isnot amenable to analytical solutions. In this paper, we introducegeneralized conversion formulae that reconcile these two models. Ingeneral, we find that the Gardner parameter alpha G is related to the vanGenuchten parameters alpha vG and n by alpha G/alpha vG ~; 1.3 n. Thisconversion rule will allow direct recasting of Gardner-based analyticalsolutions in the van Genuchten parameter space. The validity of theproposed formulae was tested by comparing the predicted relativepermeability of various porous media with measured values.

  3. Scaling laws for van der Waals interactions in nanostructured materials.

    PubMed

    Gobre, Vivekanand V; Tkatchenko, Alexandre

    2013-01-01

    Van der Waals interactions have a fundamental role in biology, physics and chemistry, in particular in the self-assembly and the ensuing function of nanostructured materials. Here we utilize an efficient microscopic method to demonstrate that van der Waals interactions in nanomaterials act at distances greater than typically assumed, and can be characterized by different scaling laws depending on the dimensionality and size of the system. Specifically, we study the behaviour of van der Waals interactions in single-layer and multilayer graphene, fullerenes of varying size, single-wall carbon nanotubes and graphene nanoribbons. As a function of nanostructure size, the van der Waals coefficients follow unusual trends for all of the considered systems, and deviate significantly from the conventionally employed pairwise-additive picture. We propose that the peculiar van der Waals interactions in nanostructured materials could be exploited to control their self-assembly.

  4. Frequency of VanA, VanB and VanH variants amongst vancomycin-resistant enterococci isolated from patients in central region of Iran

    PubMed Central

    Rezvani, Jaafar; Nasr, Reza; T. Shamsabadi, Fatemeh; Akbari Eidgahi, Mohammad Reza

    2016-01-01

    Aim: The aim of this study was to investigate the VRE frequency and the rate of each gene in isolated enterococci from patients with intestinal infection in the central region of Iran. Background: Enterococci infections are a public health growing concern due to the glycopeptide antibiotics resistance especially vancomycin. Genes, vanA, B, and H contribute to the influence of vancomycin-resistant enterococci (VRE). Patients and methods: This study was conducted from January to July 2014 in Shahrood university hospital. Enterococci isolation and its antibacterial susceptibility were performed by culturing in Aesculin Azide agar and Kirby-Bauer method, respectively. Vancomycin-resistant genes were screened through conventional PCR, and subsequently sequenced. Results: Among 265 specimens, 100 isolates revealed enterococci, in which E. faecalis (91%) and E. faecium (9%). The isolated enterococci were resistant to vancomycin (6%) and chloramphenicol (21%), whereas their large proportions (94% to 100%) were multi-drug resistant. All VRE isolates belonged to E. faecalis, conversely, the E. faecium were susceptible to the same antibiotic. Both vanA and vanH genes were identified in all VRE isolates, although, no vanB gene was indicated. Homology analysis of sequenced amplicons verified the full length compatibility to the worldwide reported genes. Conclusion: The present study revealed VR E. faecalis in gastroenteritis patients and resistance factor for vanA and vanH genes are coordinated. Since enterococci isolates were all multidrug resistance, increase in VR E. faecalis vanA / vanH in this area could be expected. PMID:27895857

  5. Dancing bunches as Van Kampen modes

    SciTech Connect

    Burov, A.; /Fermilab

    2011-03-01

    Van Kampen modes are eigen-modes of Jeans-Vlasov equation [1-3]. Their spectrum consists of continuous and, possibly, discrete parts. Onset of a discrete van Kampen mode means emergence of a coherent mode without any Landau damping; thus, even a tiny couple-bunch wake is sufficient to drive instability. Longitudinal instabilities observed at Tevatron [4], RHIC [5] and SPS [6] can be explained as loss of Landau damping (LLD), which is shown here to happen at fairly low impedances. For repulsive wakes and single-harmonic RF, LLD is found to be extremely sensitive to steepness of the bunch distribution function at small amplitudes. Based on that, a method of beam stabilization is suggested. Emergence of a discrete van Kampen mode means either loss of Landau damping or instability. Longitudinal bunch stability is analysed in weak head-tail approximation for inductive impedance and single-harmonic RF. The LLD threshold intensities are found to be rather low: for cases under study all of them do not exceed a few percent of the zero-amplitude incoherent synchrotron frequency shift, strongly decreasing for shorter bunches. Because of that, LLD can explain longitudinal instabilities happened at fairly low impedances at Tevatron [4], and possibly for RHIC [5] and SPS [6], being in that sense an alternative to the soliton explanation [5, 20]. Although LLD itself results in many cases in emergence of a mode with zero growth rate, any couple-bunch (and sometimes multi-turn) wake would drive instability for that mode, however small this wake is. LLD is similar to a loss of immune system of a living cell, when any microbe becomes fatal for it. The emerging discrete mode is normally very different from the rigid-bunch motion; thus the rigid-mode model significantly overestimates the LLD threshold. The power low of LLD predicted in Ref. [17] agrees with results of this paper. However, the numerical factor in that scaling low strongly depends on the bunch distribution function

  6. Rater Biases in Genetically Informative Research Designs: Comment on Bartels, Boomsma, Hudziak, van Beijsterveldt, and van den Oord (2007)

    ERIC Educational Resources Information Center

    Hoyt, William T.

    2007-01-01

    Rater biases are of interest to behavior genetic researchers, who often use ratings data as a basis for studying heritability. Inclusion of multiple raters for each sibling pair (M. Bartels, D. I. Boomsma, J. J. Hudziak, T. C. E. M. van Beijsterveldt, & E. J. C. G. van den Oord, 2007) is a promising strategy for controlling bias variance and may…

  7. Do bees like Van Gogh's Sunflowers?

    NASA Astrophysics Data System (ADS)

    Chittka, Lars; Walker, Julian

    2006-06-01

    Flower colours have evolved over 100 million years to address the colour vision of their bee pollinators. In a much more rapid process, cultural (and horticultural) evolution has produced images of flowers that stimulate aesthetic responses in human observers. The colour vision and analysis of visual patterns differ in several respects between humans and bees. Here, a behavioural ecologist and an installation artist present bumblebees with reproductions of paintings highly appreciated in Western society, such as Van Gogh's Sunflowers. We use this unconventional approach in the hope to raise awareness for between-species differences in visual perception, and to provoke thinking about the implications of biology in human aesthetics and the relationship between object representation and its biological connotations.

  8. Ellis-van Creveld syndrome and dyserythropoiesis.

    PubMed

    Scurlock, Deven; Ostler, Daniel; Nguyen, Andy; Wahed, Amer

    2005-05-01

    Ellis-van Creveld (EVC) syndrome or chondroectodermal dysplasia is a rare autosomal recessive disorder characterized by a variable spectrum of clinical findings. Classical EVC syndrome comprises a tetrad of clinical manifestations of chondrodystrophy, polydactyly, ectodermal dysplasia, and cardiac defects. In several case reports, dysplasia involving other organs has also been identified. Hematologic abnormalities have been rarely reported in patients with EVC syndrome. Here, we report a case of a 3-year-old Hispanic boy with EVC syndrome and marked dyserythropoiesis. The dyserythropoiesis may be part of an isolated myelodysplastic change or a primary myelodysplastic syndrome and likely represents an unusual EVC syndrome association. To our knowledge, this association has not been previously reported.

  9. Human fasciolosis in Van province, Turkey.

    PubMed

    Yilmaz, Hasan; Gödekmerdan, Ahmet

    2004-10-01

    This investigation was carried out to determine the frequency of the fasciolosis in Erciş, a town in the Van province located in the Eastern Turkey. The study includes 500 asymptomatic subjects (322 males and 178 females) whose ages ranged from 5 to 75 years. In all subjects, stool samples were examined at initiation of the study and one week later to rule out pseudoparasitosis. The methods of flotation (in saturated saline solution) and sedimentation (in formalin-ether solution) were used in examination of the stool samples. Fasciola hepatica eggs were detected in nine (1.8%) out of 500 subjects. In conclusion, our data showed that the prevalence of human fasciolosis was high in our region because watercress consumption was common. We also think that human fasciolosis is more frequent than expected in Turkey. To determine the exact prevalence of the disease, extensive serological investigations should be performed in different regions of Turkey.

  10. Direct synthesis of van der Waals solids.

    PubMed

    Lin, Yu-Chuan; Lu, Ning; Perea-Lopez, Nestor; Li, Jie; Lin, Zhong; Peng, Xin; Lee, Chia Hui; Sun, Ce; Calderin, Lazaro; Browning, Paul N; Bresnehan, Michael S; Kim, Moon J; Mayer, Theresa S; Terrones, Mauricio; Robinson, Joshua A

    2014-04-22

    The stacking of two-dimensional layered materials, such as semiconducting transition metal dichalcogenides (TMDs), insulating hexagonal boron nitride (hBN), and semimetallic graphene, has been theorized to produce tunable electronic and optoelectronic properties. Here we demonstrate the direct growth of MoS2, WSe2, and hBN on epitaxial graphene to form large-area van der Waals heterostructures. We reveal that the properties of the underlying graphene dictate properties of the heterostructures, where strain, wrinkling, and defects on the surface of graphene act as nucleation centers for lateral growth of the overlayer. Additionally, we show that the direct synthesis of TMDs on epitaxial graphene exhibits atomically sharp interfaces. Finally, we demonstrate that direct growth of MoS2 on epitaxial graphene can lead to a 10(3) improvement in photoresponse compared to MoS2 alone.

  11. Hyperdislocations in van der Waals Layered Materials.

    PubMed

    Ly, Thuc Hue; Zhao, Jiong; Keum, Dong Hoon; Deng, Qingming; Yu, Zhiyang; Lee, Young Hee

    2016-12-14

    Dislocations are one-dimensional line defects in three-dimensional crystals or periodic structures. It is common that the dislocation networks made of interactive dislocations be generated during plastic deformation. In van der Waals layered materials, the highly anisotropic nature facilitates the formation of such dislocation networks, which is critical for the friction or exfoliation behavior for these materials. By transmission electron microscopy analysis, we found the topological defects in such dislocation networks can be perfectly rationalized in the framework of traditional dislocation theory, which we applied the name "hyperdislocations". Due to the strong pinning effect of hyperdislocations, the state of exfoliation can be easily triggered by 1° twisting between two layers, which also explains the origin of disregistry and frictionlessness for all of the superlubricants that are widely used for friction reduction and wear protection.

  12. Resonance Van Hove singularities in wave kinetics

    NASA Astrophysics Data System (ADS)

    Shi, Yi-Kang; Eyink, Gregory L.

    2016-10-01

    Wave kinetic theory has been developed to describe the statistical dynamics of weakly nonlinear, dispersive waves. However, we show that systems which are generally dispersive can have resonant sets of wave modes with identical group velocities, leading to a local breakdown of dispersivity. This shows up as a geometric singularity of the resonant manifold and possibly as an infinite phase measure in the collision integral. Such singularities occur widely for classical wave systems, including acoustical waves, Rossby waves, helical waves in rotating fluids, light waves in nonlinear optics and also in quantum transport, e.g. kinetics of electron-hole excitations (matter waves) in graphene. These singularities are the exact analogue of the critical points found by Van Hove in 1953 for phonon dispersion relations in crystals. The importance of these singularities in wave kinetics depends on the dimension of phase space D =(N - 2) d (d physical space dimension, N the number of waves in resonance) and the degree of degeneracy δ of the critical points. Following Van Hove, we show that non-degenerate singularities lead to finite phase measures for D > 2 but produce divergences when D ≤ 2 and possible breakdown of wave kinetics if the collision integral itself becomes too large (or even infinite). Similar divergences and possible breakdown can occur for degenerate singularities, when D - δ ≤ 2, as we find for several physical examples, including electron-hole kinetics in graphene. When the standard kinetic equation breaks down, then one must develop a new singular wave kinetics. We discuss approaches from pioneering 1971 work of Newell & Aucoin on multi-scale perturbation theory for acoustic waves and field-theoretic methods based on exact Schwinger-Dyson integral equations for the wave dynamics.

  13. van Vleck determinants: Traversable wormhole spacetimes

    SciTech Connect

    Visser, M. )

    1994-04-15

    Prompted by various questions regarding the putative existence, stability, and chronological properties of traversable wormholes, a number of authors have presented calculations of the renormalized stress-energy tensor in wormhole spacetimes. In particular, the use of point-splitting techniques leads to expressions that contain the van Vleck determinant as a common prefactor. Recent technical advances permit one to undertake extensive computations of the van Vleck determinant in traversable wormhole spacetimes, at least in the short-throat flat-space approximation. This paper presents several such computations for various model spacetimes. Implications with regard to Hawking's chronology protection conjecture are discussed. In particular, any attempt to transform a single isolated wormhole into a time machine results in large vacuum polarization effects. These vacuum polarization effects are sufficient to disrupt the internal structure of the wormhole long before the onset of Planck scale physics, and before the onset of time travel. Thus for isolated wormholes, vacuum polarization effects are sufficient to enforce Hawking's chronology protection conjecture. On the other hand, it is possible to conceive of a putative time machine built out of two or more wormholes, each of which taken in isolation is not itself a time machine. Such Roman configurations'' are much more subtle to analyze. For reasonable'' configurations (traversable by humans) the vacuum polarization effects in such multiple wormhole putative time machines become large long before the onset of Planck scale physics. The disruption scale for would-be traversable time machines'' is well above the Planck length. On the other hand, for some particularly bizarre configurations (not traversable by humans) the vacuum polarization effects can be arranged to be arbitrarily small at the onset of Planck scale physics.

  14. KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  15. KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  16. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial.

    PubMed

    Zanchetti, Alberto; Bond, M Gene; Hennig, Michael; Neiss, Albrecht; Mancia, Giuseppe; Dal Palù, Cesare; Hansson, Lennart; Magnani, Bruno; Rahn, Karl-Heinz; Reid, John L; Rodicio, Josè; Safar, Michel; Eckes, Lothar; Rizzini, Paolo

    2002-11-05

    Most cardiovascular events associated with hypertension are complications of atherosclerosis. Some antihypertensive agents influence experimental models of atherosclerosis through mechanisms independent of blood pressure lowering. The European Lacidipine Study on Atherosclerosis (ELSA) was a randomized, double-blind trial in 2334 patients with hypertension that compared the effects of a 4-year treatment based on either lacidipine or atenolol on an index of carotid atherosclerosis, the mean of the maximum intima-media thicknesses (IMT) in far walls of common carotids and bifurcations (CBM(max)). This index has been shown by epidemiological studies to be predictive of cardiovascular events. A significant (P<0.0001) effect of lacidipine was found compared with atenolol, with a treatment difference in 4-year CBM(max) progression of -0.0227 mm (intention-to-treat population) and -0.0281 mm (completers). The yearly IMT progression rate was 0.0145 mm/y in atenolol-treated and 0.0087 mm/y in lacidipine-treated patients (completers, 40% reduction; P=0.0073). Patients with plaque progression were significantly less common, and patients with plaque regression were significantly more common in the lacidipine group. Clinic blood pressure reductions were identical with both treatments, but 24-hour ambulatory systolic/diastolic blood pressure changes were greater with atenolol (-10/-9 mm Hg) than with lacidipine (-7/-5 mm Hg). No significant difference between treatments was found in any cardiovascular events, although the relative risk for stroke, major cardiovascular events, and mortality showed a trend favoring lacidipine. The greater efficacy of lacidipine on carotid IMT progression and number of plaques per patient, despite a smaller ambulatory blood pressure reduction, indicates an antiatherosclerotic action of lacidipine independent of its antihypertensive action.

  17. Work-Family Conflict and Self-Rated Health: the Role of Gender and Educational Level. Baseline Data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Griep, Rosane Härter; Toivanen, Susanna; van Diepen, Cornelia; Guimarães, Joanna M N; Camelo, Lidyane V; Juvanhol, Leidjaira Lopes; Aquino, Estela M; Chor, Dóra

    2016-06-01

    This study examined gender differences in the association between work-family conflict and self-rated health and evaluated the effect of educational attainment. We used baseline data from ELSA-Brasil, a cohort study of civil servants from six Brazilian state capitals. Our samples included 12,017 active workers aged 34-72 years. Work-family conflict was measured by four indicators measuring effects of work on family, effects of family in work and lack of time for leisure and personal care. Women experienced more frequent work-family conflict, but in both genders, increased work-family conflict directly correlated with poorer self-rated health. Women's educational level interacted with three work-family conflict indicators. For time-based effects of work on family, highly educated women had higher odds of suboptimal self-rated health (OR = 1.54; 95 % CI = 1.19-1.99) than less educated women (OR = 1.14; 95 % CI = 0.92-1.42). For strain-based effects of work on family, women with higher and lower education levels had OR = 1.91 (95 % CI 1.48-2.47) and OR = 1.40 (95 % CI 1.12-1.75), respectively. For lack of time for leisure and personal care, women with higher and lower education levels had OR = 2.60 (95 % CI = 1.95-3.47) and OR = 1.11 (95 % CI = 0.90-1.38), respectively. Women's education level affects the relationship between work-family conflict and self-rated health. The results may contribute to prevention activities.

  18. The extraordinary career of Professor Dr. Simon van Creveld.

    PubMed

    Stoelinga, Paul J W; Berdon, Walter E; Cohen, M Michael

    2014-11-01

    Simon van Creveld received both the MD and PhD degrees and had a multifaceted medical and scientific education at many hospitals and research institutes in the Netherlands, Germany, and the UK. He and his wife were the first to develop insulin for the Netherlands. His major interests were in hemophilia and hemorrhagic disorders, which accounted for 87 of his publications. In 1934, van Creveld demonstrated that a dispersed protein fraction obtained from serum could reduce the clotting time of hemophilic blood. His interest in glycogen storage disease resulted in van Creveld-von Gierke disease for which van Creveld contributed four published articles. The Ellis-van Creveld syndrome, also known as chondroectodermal dysplasia, was published in 1940 and became well known to medical geneticists. During the Nazi occupation of the Netherlands, van Creveld's professorship was taken away from him because he was Jewish. His visits to hospitals of concentration camps to treat babies and give pediatric advice while wearing a Jewish Yellow Star and interacting with SS Commandants in charge, and then leaving can only be described as amazing. After the war, his professorship was returned, and in the same year as his retirement, he established a large Hemophila Treatment and Research Center now known as the Van Creveld Clinic, which celebrated its 40th anniversary in 2005.

  19. Transcriptional Regulation of the Vanillate Utilization Genes (vanABK Operon) of Corynebacterium glutamicum by VanR, a PadR-Like Repressor

    PubMed Central

    Lange, Julian; Watzlawick, Hildegard; Kalinowski, Jörn; Altenbuchner, Josef

    2014-01-01

    Corynebacterium glutamicum is able to utilize vanillate, the product of lignin degradation, as the sole carbon source. The vanillate utilization components are encoded by the vanABK operon. The vanA and vanB genes encode the subunits of vanillate O-demethylase, converting vanillate to protocatechuate, while VanK is the specific vanillate transporter. The vanABK operon is regulated by a PadR-type repressor, VanR. Heterologous gene expression and variations of the vanR open reading frame revealed that the functional VanR contains 192 residues (21 kDa) and forms a dimer, as analyzed by size exclusion chromatography. In vivo, ferulate, vanillin, and vanillate induced PvanABK in C. glutamicum, while only vanillate induced the activity of PvanABK in Escherichia coli lacking the ferulate catabolic system. Differential scanning fluorimetry verified that vanillate is the only effector of VanR. Interaction between the PvanABK DNA fragment and the VanR protein had an equilibrium dissociation constant (KD) of 15.1 ± 1.7 nM. The VanR-DNA complex had a dissociation rate constant (Kd) of (267 ± 23) × 10−6 s−1, with a half-life of 43.5 ± 3.6 min. DNase I footprinting localized the VanR binding site at PvanABK, extending from +9 to +45 on the coding strand. Deletion of the nucleotides +18 to +27 inside the VanR binding site rendered PvanABK constitutive. Fusion of the T7 promoter and the wild-type VanR operator, as well as its shortened versions, indicated that the inverted repeat AACTAACTAA(N4)TTAGGTATTT is the specific VanR binding site. It is proposed that the VanR-DNA complex contains two VanR dimers at the VanR operator. PMID:25535273

  20. Vehicle test report: Jet Industries Electra Van 600

    NASA Technical Reports Server (NTRS)

    Price, T. W.; Wirth, V. A., Jr.

    1982-01-01

    The Electra Van 600, an electric vehicle, was tested. Tests were performed to characterize parameters of the Electra Van 600 and to provide baseline data to be used for comparison of improved batteries and to which will be incorporated into the vehicle. The vehicle tests concentrated on the electrical drive subsystem, the batteries, controller, and motor; coastdowns to characterize the road load and range evaluation for cyclic and constant speed conditions; and qualitative performance was evaluated. It is found that the Electra Van 600 range performance is approximately equal to the majority of the vehicles tested previously.

  1. Synchronization law for a van der Pol array.

    PubMed

    Peles, Slaven; Wiesenfeld, Kurt

    2003-08-01

    We explore the transition to in-phase synchronization in globally coupled oscillator arrays, and compare results for van der Pol arrays with Josephson junction arrays. Our approach yields in each case an analytically tractable iterative map; the resulting stability formulas are simple because the expansion procedure identifies natural parameter groups. A third example, an array of Duffing-van der Pol oscillators, is found to be of the same fundamental type as the van der Pol arrays, but the Josephson arrays are fundamentally different owing to the absence of self-resonant interactions.

  2. [The simultaneous contrast of the colors in Van Gogh paints].

    PubMed

    Cernea, P

    2002-01-01

    Vincent Van Gogh, Dutchman painter, is a forerunner but also a spokesman of the expressionism. His life was short and sad, marked by a psychic instability. In his paintings the color is subordinated of some subjective motivations. Van Gogh uses complementary colors to get a maximum intensity of the overlapped tones. The chromatic increase serves to obtain some strong emotions. In his landscapes the special distances are suggested through tonal distances. The increase of the pure tones through complementary contrast, the cancel of the imitation colors through sensation-colors, the explosive chromatic are characteristic of her painting. In his singular creation, Vincent Van Gogh created his suffering ego.

  3. Characterization of an Enterococcus gallinarum Isolate Carrying a Dual vanA and vanB Cassette.

    PubMed

    Eshaghi, Alireza; Shahinas, Dea; Li, Aimin; Kariyawasam, Ruwandi; Banh, Philip; Desjardins, Marc; Melano, Roberto G; Patel, Samir N

    2015-07-01

    The ability of vancomycin resistance determinants to be horizontally transferred within enterococci species is a concern. Identification and characterization of vancomycin-resistant enterococci (VRE) in a clinical isolate have a significant impact on infection control practices. In this study, we describe a clinical isolate of Enterococcus gallinarum exhibiting high-level resistance to vancomycin and teicoplanin. The genetic characterization of this isolate showed the presence of vanA and vanB genes in addition to the naturally carried vanC gene. vanA was identified on pA6981, a 35,608-bp circular plasmid with significant homology to plasmid pS177. The vanB operon was integrated into the bacterial chromosome and showed a high level of homology to previously reported Tn1549 and Tn5382. To the best of our knowledge, this is the first report of E. gallinarum carrying both vanA and vanB operons, indicating the importance of identifying the vancomycin resistance mechanism in non-E. faecium and non-E. faecalis enterococcal species.

  4. Characterization of an Enterococcus gallinarum Isolate Carrying a Dual vanA and vanB Cassette

    PubMed Central

    Eshaghi, Alireza; Shahinas, Dea; Li, Aimin; Kariyawasam, Ruwandi; Banh, Philip; Desjardins, Marc; Melano, Roberto G.

    2015-01-01

    The ability of vancomycin resistance determinants to be horizontally transferred within enterococci species is a concern. Identification and characterization of vancomycin-resistant enterococci (VRE) in a clinical isolate have a significant impact on infection control practices. In this study, we describe a clinical isolate of Enterococcus gallinarum exhibiting high-level resistance to vancomycin and teicoplanin. The genetic characterization of this isolate showed the presence of vanA and vanB genes in addition to the naturally carried vanC gene. vanA was identified on pA6981, a 35,608-bp circular plasmid with significant homology to plasmid pS177. The vanB operon was integrated into the bacterial chromosome and showed a high level of homology to previously reported Tn1549 and Tn5382. To the best of our knowledge, this is the first report of E. gallinarum carrying both vanA and vanB operons, indicating the importance of identifying the vancomycin resistance mechanism in non-E. faecium and non-E. faecalis enterococcal species. PMID:25948610

  5. Glycopeptide Resistance vanA Operons in Paenibacillus Strains Isolated from Soil

    PubMed Central

    Guardabassi, Luca; Perichon, Bruno; van Heijenoort, Jean; Blanot, Didier; Courvalin, Patrice

    2005-01-01

    The sequence and gene organization of the van operons in vancomycin (MIC of >256 μg/ml)- and teicoplanin (MIC of ≥32 μg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the corresponding genes in enterococcal vanA and vanB operons. The vanAPT operon in P. thiaminolyticus PT-2B1 had the same gene organization as that of vanA operons whereas vanAPA in P. apiarius PA-B2B resembled vanB operons due to the presence of vanW upstream from the vanHAX cluster but was closer to vanA operons in sequence. Reference P. apiarius strains NRRL B-4299 and NRRL B-4188 were found to harbor operons indistinguishable from vanAPA by PCR mapping, restriction fragment length polymorphism, and partial sequencing, suggesting that this operon was species specific. As in enterococci, resistance was inducible by glycopeptides and associated with the synthesis of pentadepsipeptide peptidoglycan precursors ending in d-Ala-d-Lac, as demonstrated by d,d-dipeptidase activities, high-pressure liquid chromatography, and mass spectrometry. The precursors differed from those in enterococci by the presence of diaminopimelic acid instead of lysine in the peptide chain. Altogether, the results are compatible with the notion that van operons in soil Paenibacillus strains and in enterococci have evolved from a common ancestor. PMID:16189102

  6. Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.

    PubMed

    Guardabassi, Luca; Perichon, Bruno; van Heijenoort, Jean; Blanot, Didier; Courvalin, Patrice

    2005-10-01

    The sequence and gene organization of the van operons in vancomycin (MIC of >256 microg/ml)- and teicoplanin (MIC of > or =32 microg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the corresponding genes in enterococcal vanA and vanB operons. The vanA(PT) operon in P. thiaminolyticus PT-2B1 had the same gene organization as that of vanA operons whereas vanA(PA) in P. apiarius PA-B2B resembled vanB operons due to the presence of vanW upstream from the vanHAX cluster but was closer to vanA operons in sequence. Reference P. apiarius strains NRRL B-4299 and NRRL B-4188 were found to harbor operons indistinguishable from vanA(PA) by PCR mapping, restriction fragment length polymorphism, and partial sequencing, suggesting that this operon was species specific. As in enterococci, resistance was inducible by glycopeptides and associated with the synthesis of pentadepsipeptide peptidoglycan precursors ending in D-Ala-D-Lac, as demonstrated by D,D-dipeptidase activities, high-pressure liquid chromatography, and mass spectrometry. The precursors differed from those in enterococci by the presence of diaminopimelic acid instead of lysine in the peptide chain. Altogether, the results are compatible with the notion that van operons in soil Paenibacillus strains and in enterococci have evolved from a common ancestor.

  7. "Public" and "Private" Meanings: The Paintings of van Gogh.

    ERIC Educational Resources Information Center

    Roskill, Mark

    1979-01-01

    Examines the distinctions and interrelation of the artist's intentions and the viewers' understanding of a work of art by using the work of Vincent van Gogh and relating it to the artist's correspondence about his own work. (JMF)

  8. Astronaut James D. van Hoften examines student experiment on Challenger

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut James D. van Hoften, 41-C mission specialist, holds an aluminum box full of honeybees. The experiment in earth orbit is duplicated with another colony of the bees on earth. This is an experiment submitted by student researchers.

  9. 1. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer June 1960 FRONT (SOUTH) ELEVATION SHOWING ORIGINAL ONE STORY BUILDING - Ship-Carpenter's House, Main Street, Bethel, Sussex County, DE

  10. 1. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer June 1960 FRONT (SOUTH) ELEVATION SHOWING ORIGINAL ONE STORY BUILDING - Ship Carpenter's House, Main Street, Bethel, Sussex County, DE

  11. 1. Photocopy from stereoptican picture (original owned by Charles van ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy from stereoptican picture (original owned by Charles van Ravenswaay, Wilmington, Delaware) J. C. Macurdy, Photographer ca. 1871 EXTERIOR IN 1871 - St. Peter & Paul Roman Catholic Church, Seventh & Spring Streets, Boonville, Cooper County, MO

  12. Electric G-Van demonstration and commercial assessment project

    SciTech Connect

    Braga, B.D. )

    1992-12-01

    The Electric Power Research Institute was awarded this grant to continue the joint effort initiated by EPRI, and VE International to proceed beyond the prototype phase of the electric G-Van development. The goal of EPRI and VEHMA was to develop a market for the electric G-Van, and to distribute them to commercial fleet operators. The objective of this project was to produce G-Vans in a production facility that would be comparable to the GMC Truck internal combustion engine Vandura Van produced by General Motors in quality, reliability, durability and safety. An initial market assessment/demonstration phase of sixty (60) vehicles was to be undertaken, with the ability to expand production volume quickly to meet market demands. Brief description of each task of this grant is given and the actions taken by EPRI to complete them.

  13. 7. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 DETAIL OF WEST ELEVATION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  14. 11. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 INTERIOR DETAIL OF FRAME CONSTRUCTION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  15. 6. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 DETAIL OF WEST ELEVATION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  16. 10. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 NORTHWEST CORNER OF 'GREAT ROOM' - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  17. 5. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 MOULDING AND DENTIL COURSE ON SOUTH ELEVATION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  18. 9. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 INTERIOR WITH CLOSED FIREPLACE - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  19. 4. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 SOUTHWEST CORNER - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  20. 8. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 BRICK NOGGING AND ORIGINAL WEATHERBOARDING OF SOUTH ELEVATION - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  1. 2. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 SOUTH AND WEST ELEVATIONS - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  2. 3. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer October 1959 SOUTHEAST CORNER - White Meadow Farm, State Roads 290 & 262 (moved to Lewes, DE), Cool Spring, Sussex County, DE

  3. Isotope separation by photodissociation of Van der Waal's molecules

    DOEpatents

    Lee, Yuan T.

    1977-01-01

    A method of separating isotopes based on the dissociation of a Van der Waal's complex. A beam of molecules of a Van der Waal's complex containing, as one partner of the complex, a molecular species in which an element is present in a plurality of isotopes is subjected to radiation from a source tuned to a frequency which will selectively excite vibrational motion by a vibrational transition or through electronic transition of those complexed molecules of the molecular species which contain a desired isotope. Since the Van der Waal's binding energy is much smaller than the excitational energy of vibrational motion, the thus excited Van der Waal's complex dissociate into molecular components enriched in the desired isotope. The recoil velocity associated with vibrational to translational and rotational relaxation will send the separated molecules away from the beam whereupon the product enriched in the desired isotope can be separated from the constituents of the beam.

  4. Astronauts van Hoften and Nelson conduct pre-breathing exercise

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronauts James D. van Hoften and George D. Nelson, wearing Shuttle launch and entry helmets, conduct a pre-breathing exercise on the forward flight deck of the shuttle Challenger during the STS 41-C mission.

  5. 21. View West, Detail Mural, Children's Room, Rip Van Winkle ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. View West, Detail Mural, Children's Room, Rip Van Winkle Mural, Project of the CWA (Civil Works Administration) Completed May 1934. - Ives Memorial Library, 133 Elm Street, New Haven, New Haven County, CT

  6. Astronauts van Hoften and Nelson conduct pre-breathing exercise

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronauts James D. van Hoften and George D. Nelson, wearing Shuttle launch and entry helmets, conduct a pre-breathing exercise on the forward flight deck of the shuttle Challenger during the STS 41-C mission.

  7. Art and Wound Healing: van Gogh Cypresses-like Lipodermatosclerosis.

    PubMed

    Papi, Massimo

    2016-12-01

    Lipodermatosclerosis may develop clinical aspects that have striking analogies with Van Gogh's style of painting cypresses. They may reveal specific physiopathological disorders and identify a homogeneous group of patients with chronic venous insufficiency.

  8. Van Gogh's disease in the light of his correspondence.

    PubMed

    Voskuil, Piet H A

    2013-01-01

    The literary quality of Vincent van Gogh's correspondence is widely recognized. He wrote expressively and evocatively, and had great literary knowledge. In this essay we follow his medical history in many quotes from in his letters to see how Vincent expressed his complaints, knowledge, and emotions connected with his disease. The symptoms became most clear after December 1888. In the beginning, Van Gogh hesitated to tell much about his ailment, but gradually painted in the letters his experiences, making use of the intermittent course of his cycloid psychoses. We will see an indication that, in the network that mediated Van Gogh's brain (dys)function, elements of synesthesia, prosopagnosia, and spatial agnosia might have been activated. Van Gogh's affinity for poetry, already in his early twenty's, makes the hypothesis of a, by epileptic discharges, kindled temporal lobe at most only part of the complex interpretation of this creative and suffering mind. Copyright © 2013 S. Karger AG, Basel.

  9. Astronaut James D. van Hoften examines student experiment on Challenger

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut James D. van Hoften, 41-C mission specialist, holds an aluminum box full of honeybees. The experiment in earth orbit is duplicated with another colony of the bees on earth. This is an experiment submitted by student researchers.

  10. EPA awards Van Buren, Ark. Teacher with Presidential Innovation Award

    EPA Pesticide Factsheets

    DALLAS - (July 17, 2015) The U.S. Environmental Protection Agency has awarded Jolie Hobbs of King Elementary School in Van Buren, Ark. with the Presidential Innovation Award for Environmental Educators (PIAEE). She was honored today at a ceremony at

  11. 2. Photocopy of photograph (from collection of Charles van Ravenswaay) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph (from collection of Charles van Ravenswaay) Photographer unknown, 1871. LOOKING EAST ON VINE STREET FROM STEEPLE OF PRESBYTERIAN CHURCH AT CORNER OF MAIN AND VINE STREETS. - Town of Boonville, Boonville, Cooper County, MO

  12. 1. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Cortlandt Van Dyke Hubbard, Photographer June 1960 EXTERIOR OF THE SOUTH AND EAST ELEVATIONS - The Judges Law Office, 100 West Market Street, Georgetown, Sussex County, DE

  13. Astronaut James van Hoften working with Syncom IV-3 satellite

    NASA Image and Video Library

    1985-09-01

    51I-44-014 (31 Aug-1 Sept. 1985) --- This photograph is one of a series of six covering extravehicular activity (EVA) which were released by NASA on Sept. 4, 1985. Here, astronaut James D. van Hoften, dwarfed by the large satellite, moves in for initial contact. Astronaut John M. (Mike) Lounge, out of frame inside cabin, maneuvers the remote manipulator system (RMS) arm to assist astronauts van Hoften and William F. Fisher. Photo credit: NASA

  14. LEASAT-3 repair during the van Hoften and Fisher EVA

    NASA Image and Video Library

    1985-08-31

    51I-44-012 (1 Sept. 1985) --- Astronaut James D. van Hoften looks on as the Syncom IVC-3 satellite responds to his push against it moments earlier. Dr. van Hoften, mission specialist, is anchored to a foot restraint on the end of the remote manipulator system (RMS) arm of the Earth-orbiting space shuttle Discovery. The 51-I crew members showed this photograph at their Sept. 11 postflight press conference. Photo credit: NASA

  15. Lifshitz theory of van der Waals pressure in dissipative media

    SciTech Connect

    Zheng Yi; Narayanaswamy, Arvind

    2011-04-15

    We derive a first-principles method of determining the van der Waals or Casimir pressure in a dissipative and dispersive planar multilayered system by calculating the Maxwell stress tensor in a fictitious layer of vacuum, that is eventually made to vanish, introduced in the structure. This is illustrated by calculating the van der Waals pressure in a thin film with dissipative properties embedded between two semi-infinite media.

  16. Astronaut James van Hoften working with Syncom IV-3 satellite

    NASA Image and Video Library

    1985-09-01

    51I-102-029 (31 August - 1 September 1985) --- This is one of a series of six photographs released by NASA covering the extravehicular activity (EVA) of astronauts James D. van Hoften and William F. Fisher, who helped to capture, repair and release the previously errant Syncom IV-3 communications satellite. Here, Dr. van Hoften has just given a shove to the the Syncom. (For orientation, moon should be in lower right quadrant).

  17. From the corner of Charlie Kelly Blvd. And S. Van ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    From the corner of Charlie Kelly Blvd. And S. Van Valzah St., looking northwest up S. Van Valzah St. Building 604 is in the foreground and to the right of it are buildings 605 and 606. - Fitzsimons General Hospital, Bounded by East Colfax to south, Peoria Street to west, Denver City/County & Adams County Line to north, & U.S. Route 255 to east, Aurora, Adams County, CO

  18. The research contributions of Dr. Paul Van Deusen

    Treesearch

    Thomas B. Lynch; Francis A. Roesch; John Paul McTague; Jeffrey H. Gove; Gregory A. Reams; Aaron R. Weiskittel

    2015-01-01

    Dr. Paul Van Deusen’s recent passing concluded a rich 30+-year research career dedicated to development and implementation of quantitative methods for forestry and natural resources. Since the early part of his career as a biometrician with the USDA Forest Service Southern Research Station in the 1980s-1990s and continuing with his later employment at NCASI, Dr. Van...

  19. Ellis-van Creveld syndrome. Case report and literature review.

    PubMed

    Alves-Pereira, Daniela; Berini-Aytés, Leonardo; Gay-Escoda, Cosme

    2009-07-01

    Ellis-van Creveld syndrome is a genetic disorder that was first described by Richard Ellis and Simon van Creveld in 1940. The four principal characteristics are chondrodysplasia, polydactyly, ectodermal dysplasia and congenital heart defects. The orofacial manifestations include multiple gingivolabial musculofibrous fraenula, dental anomalies, hypodontia and malocclusion. The disease can be diagnosed at any age, even during pregnancy. The differentiation should be made between Jeune syndrome and other orofaciodigital syndromes.

  20. Van der Waals Interactions in Aspirin

    NASA Astrophysics Data System (ADS)

    Reilly, Anthony; Tkatchenko, Alexandre

    2015-03-01

    The ability of molecules to yield multiple solid forms, or polymorphs, has significance for diverse applications ranging from drug design and food chemistry to nonlinear optics and hydrogen storage. In particular, aspirin has been used and studied for over a century, but has only recently been shown to have an additional polymorphic form, known as form II. Since the two observed solid forms of aspirin are degenerate in terms of lattice energy, kinetic effects have been suggested to determine the metastability of the less abundant form II. Here, first-principles calculations provide an alternative explanation based on free-energy differences at room temperature. The explicit consideration of many-body van der Waals interactions in the free energy demonstrates that the stability of the most abundant form of aspirin is due to a subtle coupling between collective electronic fluctuations and quantized lattice vibrations. In addition, a systematic analysis of the elastic properties of the two forms of aspirin rules out mechanical instability of form II as making it metastable.

  1. [Little animals observed by Antony van Leeuwenhoek].

    PubMed

    Amako, Kazunobu

    2014-01-01

    Antony van Leeuwenhoek is the discoverer of bacteria and other microorganisms. However, his name is currently not as well-known as those of Louis Pasteur, Robert Koch or Shibasaburo Kitasato. Why not? To answer this question I read a book published in 1932 by Clifford Dobell, an English protozoologist, and found some answers. First, Leeuwenhoek was not a professional scientist in any university or scientific institute, but merely an average citizen in Delft, Holland, working as a merchant in his own shop, and later he also served as an office-holder in Delft city hall. Second, he made and invented his own microscopes but never made his work on microscopes and observation techniques widely known to the public. Accordingly, after his death, his excellent techniques for observing microorganisms were not handed down to the next generation and eventually became forgotten by the scientific community. Although he did not write any scientific paper, he did write about his observations in many letters addressed to the Royal Society of London. Dr. Dobell had translated most of them into English and included them in his book. I picked up and translated several of these letters into Japanese and have included them in this review to show how he described his observations and also what he thought about the presence of such small animals invisible to the naked eye. By reading this review I hope you will come to understand the efforts and abilities of a citizen in Delft about 340 years ago.

  2. Van der Waals Interactions Involving Proteins

    NASA Technical Reports Server (NTRS)

    Roth, Charles M.; Neal, Brian L.; Lenhoff, Abraham M.

    1996-01-01

    Van der Waals (dispersion) forces contribute to interactions of proteins with other molecules or with surfaces, but because of the structural complexity of protein molecules, the magnitude of these effects is usually estimated based on idealized models of the molecular geometry, e.g., spheres or spheroids. The calculations reported here seek to account for both the geometric irregularity of protein molecules and the material properties of the interacting media. Whereas the latter are found to fall in the generally accepted range, the molecular shape is shown to cause the magnitudes of the interactions to differ significantly from those calculated using idealized models. with important consequences. First, the roughness of the molecular surface leads to much lower average interaction energies for both protein-protein and protein-surface cases relative to calculations in which the protein molecule is approximated as a sphere. These results indicate that a form of steric stabilization may be an important effect in protein solutions. Underlying this behavior is appreciable orientational dependence, one reflection of which is that molecules of complementary shape are found to exhibit very strong attractive dispersion interactions. Although this has been widely discussed previously in the context of molecular recognition processes, the broader implications of these phenomena may also be important at larger molecular separations, e.g., in the dynamics of aggregation, precipitation, and crystal growth.

  3. Van der Waals Force Assisted Heat Transfer

    NASA Astrophysics Data System (ADS)

    Sasihithlu, K.; Pendry, J. B.; Craster, R. V.

    2017-02-01

    Phonons (collective atomic vibrations in solids) are more effective in transporting heat than photons. This is the reason why the conduction mode of heat transport in nonmetals (mediated by phonons) is dominant compared to the radiation mode of heat transport (mediated by photons). However, since phonons are unable to traverse a vacuum gap (unlike photons), it is commonly believed that two bodies separated by a gap cannot exchange heat via phonons. Recently, a mechanism was proposed [J. B. Pendry, K. Sasihithlu, and R. V. Craster, Phys. Rev. B 94, 075414 (2016)] by which phonons can transport heat across a vacuum gap - through the Van der Waals interaction between two bodies with gap less than the wavelength of light. Such heat transfer mechanisms are highly relevant for heating (and cooling) of nanostructures; the heating of the flying heads in magnetic storage disks is a case in point. Here, the theoretical derivation for modelling phonon transmission is revisited and extended to the case of two bodies made of different materials separated by a vacuum gap. Magnitudes of phonon transmission, and hence the heat transfer, for commonly used materials in the micro- and nano-electromechanical industry are calculated and compared with the calculation of conduction heat transfer through air for small gaps as well as the heat transfer calculation due to photon exchange.

  4. Van der Waals Effects on semiconductor clusters.

    PubMed

    Li, Haisheng; Chen, Weiguang; Han, Xiaoyu; Li, Liben; Sun, Qiang; Guo, Zhengxiao; Jia, Yu

    2015-09-30

    Van der Waals (vdW) interactions play an important role on semiconductors in nanoscale. Here, we utilized first-principles calculations based on density functional theory to demonstrate the growth mode transition from prolate to multiunit configurations for Gen (n = 10-50) clusters. In agreement with the injected ion drift tube techniques that "clusters with n < 70 can be thought of as loosely bound assemblies of small strongly bound fragments (such as Ge7 and Ge10 )," we found these stable fragments are connected by Ge6 , Ge9 , or Ge10 unit (from bulk diamond), via strong covalent bonds. Our calculated cations usually fragment to Ge7 and Ge10 clusters, in accordance with the experiment results that the spectra Ge7 and Ge10 correspond to the mass abundance spectra. By controlling a germanium cluster with vdW interactions parameters in the program or not, we found that the vdW effects strengthen the covalent bond from different units more strikingly than that in a single unit. With more bonds between units than the threadlike structures, the multiunit structures have larger vdW energies, explaining why the isolated nanowires are harder to produce. © 2015 Wiley Periodicals, Inc.

  5. Van der Waals interactions involving proteins.

    PubMed Central

    Roth, C M; Neal, B L; Lenhoff, A M

    1996-01-01

    Van der Waals (dispersion) forces contribute to interactions of proteins with other molecules or with surfaces, but because of the structural complexity of protein molecules, the magnitude of these effects is usually estimated based on idealized models of the molecular geometry, e.g., spheres or spheroids. The calculations reported here seek to account for both the geometric irregularity of protein molecules and the material properties of the interacting media. Whereas the latter are found to fall in the generally accepted range, the molecular shape is shown to cause the magnitudes of the interactions to differ significantly from those calculated using idealized models, with important consequences. First, the roughness of the molecular surface leads to much lower average interaction energies for both protein-protein and protein-surface cases relative to calculations in which the protein molecule is approximated as a sphere. These results indicate that a form of steric stabilization may be an important effect in protein solutions. Underlying this behavior is appreciable orientational dependence, one reflection of which is that molecules of complementary shape are found to exhibit very strong attractive dispersion interactions. Although this has been widely discussed previously in the context of molecular recognition processes, the broader implications of these phenomena may also be important at larger molecular separations, e.g., in the dynamics of aggregation, precipitation, and crystal growth. Images FIGURE 3 PMID:8789115

  6. The neuropsychiatric ailment of Vincent Van Gogh.

    PubMed

    Bhattacharyya, Kalyan B; Rai, Saurabh

    2015-01-01

    Vincent Van Gogh is one of the most celebrated creative artists of all time. All his life, he was afflicted by some kind of neurological or psychiatric disorder, which remains a mystery even today. Many historians and his personal physicians believe that he suffered from epilepsy while others felt that he was affected by Ménière's disease. Features such as hypergraphia, atypical sexuality, and viscosity of thinking suggest the possibility of Gastaut-Geschwind phenomenon, a known complication of complex partial seizure. On the contrary, some historians feel that he was forced to sever his right ear in order to get relief from troublesome tinnitus, a complication of Ménière's disease. He was addicted to the liquor absinthe, which is known to lead to xanthopsia, and many authorities argue that this was the reason for his penchant for the deep and bright yellow color in many of his paintings. Others have suggested the possibility of bipolar disorder, sunstroke, acute intermittent porphyria, and digitalis toxicity as well.

  7. Modern theory of van der Waals interactions

    NASA Astrophysics Data System (ADS)

    Dobson, John

    2014-03-01

    van der Waals (vdW, dispersion) interactions are important in diverse areas such as colloid, surface and nano science, cohesion of molecular crystals, and biomolecular science. They also provide competition in experiments to discover the fifth fundamental force.While vdW interactions have been understood in principle for a century, their quantitative first-principles prediction and modelling down to chemical contact separations have proven stubbornly difficult because the quantal many-electron problem is involved. After some brief historical material, the current state of the art will be discussed with particular reference to several approaches: pairwise additive, perturbative quantum chemical, vdW-DF, Lifshitz-like scattering, RPA-like, Adiabatic Connection Fluctuation Dissipation / Time Dependent DFT based etc.. A potentially useful classification will be introduced to aid in understanding the physical causes of departures from pairwise additivity, that is from the usual sum of C6R-6 contributions. These departures result in non-standard power law decays of nanostructure vdW interactions as a function of separation D, as well as surprising dependences of the attraction on the number, N, of atoms within each vdW-interacting fragment. Some further recent results on non-additivity will also be presented. Work supported by an Australian Research Council Discovery Grant.

  8. A Substellar Companion to van Maanen 2

    NASA Astrophysics Data System (ADS)

    Makarov, Valeri V.

    2004-01-01

    The Hipparcos data for the nearest white dwarf van Maanen 2 (=HIP 3829; distance of 4.4 pc) indicate astrometric binarity, in that the proper motion has a large first derivative not accounted for as a perspective acceleration due to changing distance. The presence of a companion was suspected, but never demonstrated, from the pre-Hipparcos astrometric measurements of photographic plates. Inspection of a digital position probability chart based on the Hipparcos Intermediate Astrometry Data reveals a pendulum-like motion of the photocenter mostly in the east-west direction with a period of about 1.5 yr. Having this period as an initial constraint, an orbital fit was obtained with the following parameters: a0=27 mas, P=1.57 yr, i=89deg, ω=95deg, Ω=92deg, and T0=1991.26. Assuming a mass of 0.83 Msolar for the primary white dwarf, the mass of the secondary is 0.08 Msolar. Covariance analysis shows, however, that the uncertainty of the semimajor axis estimate and, subsequently, of the mass estimate is great for this nearly edge-on orbit. A more robust estimate is obtained for the semiminor axis, providing a lower bound mass of the companion of 0.06+/-0.02 Msolar.

  9. [Van den Spiegel and his line].

    PubMed

    van Gijn, Jan; Gijselhart, Joost P

    2012-01-01

    Adriaan van den Spiegel or Spigelius (1578-1625) was born in Flanders to protestant parents. His father was court surgeon to William, Prince of Orange. Adriaan studied medicine in Leiden and obtained a doctoral degree in Padua. In 1616, after a period as physician to the German-Dutch student community in Padua and as court physician in central Europe, he was appointed professor of anatomy and surgery, succeeding Fabritius (1533-1619) and Casserius (1552-1616). He planned to publish a modern atlas of anatomy with etchings from the legacy of Casserius, to replace Vesalius' De humani corporis fabrica libri septem of 1543. Unfortunately he was cut short by death, like his predecessor. Eventually his pupil Bucretius published the atlas in 1627, with 78 of Casserius' illustrations and 20 new ones. In the text Spigelius calls attention to the aponeurotic fascia of the transverse and oblique abdominal muscles, on either side of the rectus abdominis muscle. He proposes the name linea semilunaris, now the official term.

  10. The neuropsychiatric ailment of Vincent Van Gogh

    PubMed Central

    Bhattacharyya, Kalyan B.; Rai, Saurabh

    2015-01-01

    Vincent Van Gogh is one of the most celebrated creative artists of all time. All his life, he was afflicted by some kind of neurological or psychiatric disorder, which remains a mystery even today. Many historians and his personal physicians believe that he suffered from epilepsy while others felt that he was affected by Ménière's disease. Features such as hypergraphia, atypical sexuality, and viscosity of thinking suggest the possibility of Gastaut-Geschwind phenomenon, a known complication of complex partial seizure. On the contrary, some historians feel that he was forced to sever his right ear in order to get relief from troublesome tinnitus, a complication of Ménière's disease. He was addicted to the liquor absinthe, which is known to lead to xanthopsia, and many authorities argue that this was the reason for his penchant for the deep and bright yellow color in many of his paintings. Others have suggested the possibility of bipolar disorder, sunstroke, acute intermittent porphyria, and digitalis toxicity as well. PMID:25745302

  11. VanA-Type MRSA (VRSA) Emerged in Surface Waters.

    PubMed

    Icgen, Bulent

    2016-09-01

    Due to the widespread occurrence of mecA-encoded methicillin resistance in Staphylococcus aureus (MRSA), treatment of staphylococcal infections is shifted to glycopeptide antibiotics like vancomycin and teicoplanin. The selective pressure of glycopeptides has eventually led to the emergence of staphylococci with increased resistance. Of great concern is vanA-encoded high level vancomycin and teicoplanin resistance in MRSA (VRSA). Therefore, this study aimed at investigating the occurrence of VRSA in surface waters. Out of 290, two staphylococcal isolates identified as MRSA Al11, Ba01, and one as MRS Co11 through 16S rRNA sequencing, also displayed high level resistance towards vancomycin and teicoplanin. These staphylococcal isolates were found to harbor vanA gene with sequence similarities of 99 %-100 % to the vanA gene extracted from vancomycin- and teicoplanin-resistant enterococcal (VRE) surface water isolates of Enterococcus faecalis Cr07, E07, Pb06 and E. faecium E330. High level glycopeptide resistance rendering protein encoded by the vanA gene, D-alanine-D-lactate ligase found in VRE, was also shown to be present in all vanA-type staphylococcal isolates through western blot. Current study elucidated that surface waters provide high potential for enterococcal vanA gene being transferred to MRSA, so called VRSA, and require special scientific consideration.

  12. Modified Van der Waals equation and law of corresponding states

    NASA Astrophysics Data System (ADS)

    Zhong, Wei; Xiao, Changming; Zhu, Yongkai

    2017-04-01

    It is well known that the Van der Waals equation is a modification of the ideal gas law, yet it can be used to describe both gas and liquid, and some important messages can be obtained from this state equation. However, the Van der Waals equation is not a precise state equation, and it does not give a good description of the law of corresponding states. In this paper, we expand the Van der Waals equation into its Taylor's series form, and then modify the fourth order expansion by changing the constant Virial coefficients into their analogous ones. Via this way, a more precise result about the law of corresponding states has been obtained, and the law of corresponding states can then be expressed as: in terms of the reduced variables, all fluids should obey the same equation with the analogous Virial coefficients. In addition, the system of 3 He with quantum effects has also been taken into consideration with our modified Van der Waals equation, and it is found that, for a normal system without quantum effect, the modification on ideal gas law from the Van der Waals equation is more significant than the real case, however, for a system with quantum effect, this modification is less significant than the real case, thus a factor is introduced in this paper to weaken or strengthen the modification of the Van der Waals equation, respectively.

  13. vanE gene cluster of vancomycin-resistant Enterococcus faecalis BM4405.

    PubMed

    Abadía Patiño, Lorena; Courvalin, Patrice; Perichon, Bruno

    2002-12-01

    Acquired VanE-type resistance to low levels of vancomycin (MIC = 16 microg/ml) in Enterococcus faecalis BM4405 is due to the inducible synthesis of peptidoglyean precursors terminating in D-alanine-D-serine (Fines,M., B. Prichon, P. Reynolds, D. Sahm, and P. Courvalin, Antimicrob. Agents Chemother. 43:2161-2164, 1999). A chromosomal location was assigned to the vanE operon by pulsed-field gel electrophoresis and hybridization, and its sequence was determined. Three genes, encoding the VanE ligase, the VanXYE DD-peptidase, and the VanTE serine racemase, that displayed 43 to 53% identity with the corresponding genes in the vanC operon were found. In addition, two genes coding for a two-component regulatory system, VanRE-VanSE, exhibiting 60 and 44% identity with VanR,-VanS, were present downstream from vanTE. However, because of a stop codon at position 78, VanSE was probably not functional. The five genes, with the same orientation, were shown to be cotranscribed by Northern analysis and reverse transcription-PCR. The vanE, vanXYE, and vanTE genes conferred inducible low-level resistance to vancomycin after cloning in E. faecalis JH2-2, probably following cross talk with a two-component regulatory system of the host.

  14. Energy Sources for Soldier Modernisation Programme Systems (Overzicht van Ontwikkelingen op het Gebied van Draagbare Energieopslag en Energieopwekking)

    DTIC Science & Technology

    1999-12-01

    bekend als de zonnecel of PV-cellen. De blauwe spiegelende platen van, amorf of kristallijn, silicium . De energieopwekking van deze systemen is...rapport TNO-MEP - R 99/490 REPORT DOCUMENTATION PAGE (MOD-NL) 1. DEFENCE REPORT NO (MOD-NL) 2. RECIPIENT’S ACCESSION NO 3. PERFORMING ORGANIZATION REPORT...11. AUTHOR(S) J.W. Raadschelders, D. Schmal 12. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) TNO instittute of Environmental Sciences, Energy

  15. REMOTE LAND MINE(FIELD) DETECTION. An Overview of Techniques (DETECTIE VAN LANDMIJNEN EN MIJNENVELDEN OP AFSTAND. Een Overzicht van de technieken),

    DTIC Science & Technology

    1994-09-01

    systeem voor mijnen of mijnenvelden essentieel. De basis principes en sterke en zwakke punten van "real time" mijnen detectie met visuele, nabij...tweede deel van het rapport worden aanbevelingen gegeven voor een toekomstig systeem voor de detectie van mijnen. Deze aanbevelingen zijn gebaseerd...multi-sensor systeem voor op een voertuig. Dit is gebaseerd op de interesse die de "Genie" toont voor een dergelijk systeem , de kosten van een

  16. van't Hoff-van der Waals osmotic pressure and energy transformers.

    PubMed

    Zener, C; Levenson, W

    1983-07-01

    We find the van't Hoff relations between osmotic pressure, freezing point depression, and boiling point elevation provide a clue on how, by using salt solutions, one may lower the cost of extracting power from low-grade heat sources. In particular, the ratio of 7 between the heat of evaporation and the heat of freezing of pure water suggests a chemical system that raises 7-fold the temperature difference between heat source and heat sink, while decreasing by the same factor the heat flux. Heat exchangers dominate the cost of heat engines operating upon low-grade heat. Their area for a fixed power output is inversely proportional to the available temperature differential. Herein lies the potential for a great cost reduction. We show that the simple van der Waals concept of a gas of hard elastic spheres suffices to understand the colligative properties of salt solutions, at least up to the concentration of the eutectic composition. This concept enables us to physically interpret the thermodynamic processes during the concentration of salt solutions by evaporation and during the mixing of ice and solid salt hydrates at their eutectic temperature. These are identical to the thermodynamic processes taking place during the isothermal compression and expansion of gases in pumps and in turbines.

  17. van't Hoff-van der Waals osmotic pressure and energy transformers

    PubMed Central

    Zener, Clarence; Levenson, William

    1983-01-01

    We find the van't Hoff relations between osmotic pressure, freezing point depression, and boiling point elevation provide a clue on how, by using salt solutions, one may lower the cost of extracting power from low-grade heat sources. In particular, the ratio of 7 between the heat of evaporation and the heat of freezing of pure water suggests a chemical system that raises 7-fold the temperature difference between heat source and heat sink, while decreasing by the same factor the heat flux. Heat exchangers dominate the cost of heat engines operating upon low-grade heat. Their area for a fixed power output is inversely proportional to the available temperature differential. Herein lies the potential for a great cost reduction. We show that the simple van der Waals concept of a gas of hard elastic spheres suffices to understand the colligative properties of salt solutions, at least up to the concentration of the eutectic composition. This concept enables us to physically interpret the thermodynamic processes during the concentration of salt solutions by evaporation and during the mixing of ice and solid salt hydrates at their eutectic temperature. These are identical to the thermodynamic processes taking place during the isothermal compression and expansion of gases in pumps and in turbines. PMID:16593343

  18. Obituary: James Alfred Van Allen, 1914-2006

    NASA Astrophysics Data System (ADS)

    Ludwig, George H.; McIlwain, Carl Edwin

    2006-12-01

    James Alfred Van Allen, world-renowned space scientist, died 9 August 2006 at the age of ninety-one. He succumbed to heart failure after a ten-week period of declining health. Van Allen served for his entire sixty-seven-year professional career as an amazingly productive researcher, space science spokesman, inspired teacher, and valued colleague. The realization by him and his associates that charged particles are trapped by the Earth's magnetic field began a whole new field of research, magnetospheric physics. Following that initial discovery, he and his associates quickly extended their observations, first to the inner planets, and then to the rest of the planets and beyond. During his tenure at Iowa, he and his group flew instruments on more than sixty successful Earth satellites and planetary spacecraft, including the first missions to the planets Venus, Mars, Jupiter, Saturn, Uranus, and Neptune. Van Allen's lifetime publication list numbers more than 275, of which many are widely-cited, seminal papers. He was the sole author of more than 125 of those papers. Beyond the research laboratory, Van Allen worked energetically throughout his career in establishing space research as a new branch of human inquiry. He was among the most sought-after as a committee member and adviser, working at the highest levels of government, including the White House and Congress, and at all levels of the national and international research establishments. Many presentations in the non-scientific arena helped to bring the exciting discoveries and challenges of space research to the attention of the general public. James Van Allen (Van to his many friends and colleagues) was born on 7 September 1914 on a small farm near Mount Pleasant, Iowa, the second of four sons of Alfred Morris Van Allen and Alma Olney Van Allen. After high school in Mount Pleasant, he entered Iowa Wesleyan College, majoring in physics and graduating summa cum laude. While there, he was introduced to geophysics

  19. Van de Graaff based positron source production

    NASA Astrophysics Data System (ADS)

    Lund, Kasey Roy

    The anti-matter counterpart to the electron, the positron, can be used for a myriad of different scientific research projects to include materials research, energy storage, and deep space flight propulsion. Currently there is a demand for large numbers of positrons to aid in these mentioned research projects. There are different methods of producing and harvesting positrons but all require radioactive sources or large facilities. Positron beams produced by relatively small accelerators are attractive because they are easily shut down, and small accelerators are readily available. A 4MV Van de Graaff accelerator was used to induce the nuclear reaction 12C(d,n)13N in order to produce an intense beam of positrons. 13N is an isotope of nitrogen that decays with a 10 minute half life into 13C, a positron, and an electron neutrino. This radioactive gas is frozen onto a cryogenic freezer where it is then channeled to form an antimatter beam. The beam is then guided using axial magnetic fields into a superconducting magnet with a field strength up to 7 Tesla where it will be stored in a newly designed Micro-Penning-Malmberg trap. Several source geometries have been experimented on and found that a maximum antimatter beam with a positron flux of greater than 0.55x10 6 e+s-1 was achieved. This beam was produced using a solid rare gas moderator composed of krypton. Due to geometric restrictions on this set up, only 0.1-1.0% of the antimatter was being frozen to the desired locations. Simulations and preliminary experiments suggest that a new geometry, currently under testing, will produce a beam of 107 e+s-1 or more.

  20. Association Between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    PubMed

    Kianoush, Sina; Bittencourt, Marcio; Lotufo, Paulo; Bensenor, Isabela; Jones, Steven R; DeFilippis, Andrew P; Toth, Peter; Otvos, James D; Tibuakuu, Martin; Hall, Michael E; Harada, Paulo H N; Blaha, Michael J

    2017-08-23

    Inflammation is suggested to be a central feature of atherosclerosis, particularly among smokers. We studied whether inflammatory biomarkers GlycA and high-sensitivity C-reactive protein are associated with cigarette smoking. A total of 11 509 participants, 6774 from the MESA (Multi-Ethnic Study of Atherosclerosis) and 4735 from ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health) were included. We evaluated the cross-sectional association between multiple measures of smoking behavior and the inflammatory biomarkers, GlycA and high-sensitivity C-reactive protein, using regression models adjusted for demographic, anthropometric, and clinical characteristics. Participants were 57.7±11.1 years old and 46.4% were men. Never, former, and current smokers comprised 51.7%, 34.0%, and 14.3% of the population, respectively. Multivariable-adjusted mean absolute difference in GlycA levels (μmol/L) with 95% confidence interval (CI) were higher for former (4.1, 95% CI, 1.7-6.6 μmol/L) and current smokers (19.9, 95% CI, 16.6-23.2 μmol/L), compared with never smokers. Each 5-unit increase in pack-years of smoking was associated with higher GlycA levels among former (0.7, 95% CI, 0.3-1.1 μmol/L) and current smokers (1.6, 95% CI, 0.8-2.4 μmol/L). Among former smokers, each 5-year increase in time since quitting smoking was associated with lower GlycA levels (-1.6, 95% CI, -2.4 to -0.8 μmol/L) and each 10-unit increase in number of cigarettes/day was associated with higher GlycA among current smokers (2.8, 95% CI, 0.5-5.2 μmol/L). There were similar significant associations between all measures of smoking behavior, and both log-transformed GlycA and high-sensitivity C-reactive protein. Acute and chronic exposure to tobacco smoking is associated with inflammation, as quantified by both GlycA and high-sensitivity C-reactive protein. These biomarkers may have utility for the study and regulation of novel and traditional tobacco products. © 2017 The Authors

  1. Tracing the geochemical evolution of alkaline Lake Van, Turkey

    NASA Astrophysics Data System (ADS)

    Kwiecien, Ola; Viehberg, Finn; Plessen, Birgit; Litt, Thomas; Tillman Meyer, Felix

    2015-04-01

    Terminal Lake Van, the world's largest soda basin, is characterised by Na-CO3-Cl water chemistry (Reimer et al., 2008), salinity of ~22 ‰ and high pH of ~9.7. The sedimentary record of the lake goes ca. 600 ka back and documents major climatic events over that period (Stockhecke et al., 2014). Alas, the longevity of the basin does not mean that it persisted unchanged over such a long time. Information collected within the ICDP PALEOVAN project clearly suggests that upon its birth the chemistry of early Lake Van was very different from its modern alkaline equivalent. Here we document, by means of proxy data, the changes in water chemistry in a transforming basin. Results of lithological (Stockhecke et al., 2014) and micropaleontological (ostracod, gastropod and diatom assemblages) analysis, combined with geochemical data (δ18O, δ13C, Mg/Ca, Sr/Ca) obtained from the biogenic and authigenic carbonate fraction imply, that early Lake Van was a relatively shallow, fresh-to-brackish and, most probably, open basin. Sedimentological information points to tectonic factors rather than climatic changes responsible for closing the lake ca. 430 ka ago. Reimer, A., Landmann, G., Kempe, S., 2008. Lake Van, Eastern Anatolia, Hydrochemistry and History. Aquat. Geochemistry 15, 195-222. Stockhecke, M., Sturm, M., Brunner, I., Schmincke, H.-U., Sumita, M., Kipfer, R., Cukur, D., Kwiecien, O., Anselmetti, F.S., 2014. Sedimentary evolution and environmental history of Lake Van (Turkey) over the past 600 000 years. Sedimentology.

  2. Eos Interviews Robert Van Hook, Former AGU Interim Executive Director

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2010-08-01

    Robert Van Hook, who served as AGU's interim executive director since January 2009, led the organization during a transition period that began with the retirement of long-serving executive director A. F. (“Fred”) Spilhaus Jr. Van Hook's tenure concluded on 30 August when Christine McEntee assumed her position as AGU's new executive director (see Eos, 91(17), 153, 156, 2010). During his tenure at AGU, which overlapped with a global economic recession, Van Hook helped to guide the organization through key structural governance changes, strategic planning, and upgrades in technology, human resources, and accounting. He also helped to revitalize public outreach and member services, among many other efforts. Van Hook, president of Transition Management Consulting, recently reflected upon his tenure, the transition period, and the future of AGU. Van Hook credits AGU's strong volunteer leadership—including past presidents Tim Killeen and Tim Grove, current president Mike McPhaden, and president-elect Carol Finn—for courage in moving the organization through a successful transition. “They were the ones who shoved the boat off from the shore. I was lucky enough to be invited into the boat,” he said. He also credits the staff for their resiliency and commitment to supporting AGU's science.

  3. Materials perspective on Casimir and van der Waals interactions

    NASA Astrophysics Data System (ADS)

    Woods, L. M.; Dalvit, D. A. R.; Tkatchenko, A.; Rodriguez-Lopez, P.; Rodriguez, A. W.; Podgornik, R.

    2016-10-01

    Interactions induced by electromagnetic fluctuations, such as van der Waals and Casimir forces, are of universal nature present at any length scale between any types of systems. Such interactions are important not only for the fundamental science of materials behavior, but also for the design and improvement of micro- and nanostructured devices. In the past decade, many new materials have become available, which has stimulated the need for understanding their dispersive interactions. The field of van der Waals and Casimir forces has experienced an impetus in terms of developing novel theoretical and computational methods to provide new insights into related phenomena. The understanding of such forces has far reaching consequences as it bridges concepts in materials, atomic and molecular physics, condensed-matter physics, high-energy physics, chemistry, and biology. This review summarizes major breakthroughs and emphasizes the common origin of van der Waals and Casimir interactions. Progress related to novel ab initio modeling approaches and their application in various systems, interactions in materials with Dirac-like spectra, force manipulations through nontrivial boundary conditions, and applications of van der Waals forces in organic and biological matter are examined. The outlook of the review is to give the scientific community a materials perspective of van der Waals and Casimir phenomena and stimulate the development of experimental techniques and applications.

  4. Materials perspective on Casimir and van der Waals interactions

    SciTech Connect

    Woods, L. M.; Dalvit, D. A. R.; Tkatchenko, A.; Rodriguez-Lopez, P.; Rodriguez, A. W.; Podgornik, R.

    2016-11-02

    Interactions induced by electromagnetic fluctuations, such as van der Waals and Casimir forces, are of universal nature present at any length scale between any types of systems. In such interactions these are important not only for the fundamental science of materials behavior, but also for the design and improvement of micro- and nanostructured devices. In the past decade, many new materials have become available, which has stimulated the need for understanding their dispersive interactions. The field of van der Waals and Casimir forces has experienced an impetus in terms of developing novel theoretical and computational methods to provide new insights into related phenomena. The understanding of such forces has far reaching consequences as it bridges concepts in materials, atomic and molecular physics, condensed-matter physics, high-energy physics, chemistry, and biology. Our review summarizes major breakthroughs and emphasizes the common origin of van der Waals and Casimir interactions. Progress related to novel ab initio modeling approaches and their application in various systems, interactions in materials with Dirac-like spectra, force manipulations through nontrivial boundary conditions, and applications of van der Waals forces in organic and biological matter are examined. Finally, the outlook of the review is to give the scientific community a materials perspective of van der Waals and Casimir phenomena and stimulate the development of experimental techniques and applications.

  5. [Implication of lead poisoning in psychopathology of Vincent van Gogh].

    PubMed

    González Luque, F J; Montejo González, A L

    1997-01-01

    The authors, by means of documental research, study the possibility that the physical and psychic symptoms of Vincent van Gogh may have been due to chronic lead poisoning. The technique and materials used by Van Gogh are analysed as the cause of repeated exposure to lead as well as the possible means of penetration of the metal. Through historical-biographical analysis, the progressive symptoms of the illness are compared with those of lead poisoning. The authors conclude that the excessive and continuous use by Van Gogh of pigments which were highly toxic due to their high lead content, such as white lead (lead carbonate) and yellow chrome (lead chromium), could have penetrated his organism by digestive system (primarily) in minimal daily amounts, giving rise to a clinical condition of chronic lead poisoning. This type of poisoning coincides with the clinical symptoms Van Gogh describes in his autographed letters: initial debilitation, stomatitis with loss of teeth, recurring abdominal pains, anaemia (with a "plumbic" skin tone), neuropathy of the radial and saturnine encephalopathy including epileptic crises, progressive character changes and periods of delirium. The clinical symptoms shown by Van Gogh meet present criteria for diagnosis of Organic Mental Disorder due to cerebral lesion or somatic illness (F.06; CIE-10) (DSM-IV-R), and Organic Character Disorder (F.07; CIE-10) (DSM-IV-R).

  6. Van der Waals interaction in uniaxial anisotropic media.

    PubMed

    Kornilovitch, Pavel E

    2013-01-23

    Van der Waals interactions between flat surfaces in uniaxial anisotropic media are investigated in the nonretarded limit. The main focus is the effect of nonzero tilt between the optical axis and the surface normal on the strength of the van der Waals attraction. General expressions for the van der Waals free energy are derived using the surface mode method and the transfer-matrix formalism. To facilitate numerical calculations a temperature-dependent three-band parameterization of the dielectric tensor of the liquid crystal 5CB is developed. A solid slab immersed in a liquid crystal experiences a van der Waals torque that aligns the surface normal relative to the optical axis of the medium. The preferred orientation is different for different materials. Two solid slabs in close proximity experience a van der Waals attraction that is strongest for homeotropic alignment of the intervening liquid crystal for all the materials studied. The results have implications for the stability of plate-like colloids in liquid crystal hosts.

  7. Evolutionary design of interfacial phase change van der Waals heterostructures.

    PubMed

    Kalikka, Janne; Zhou, Xilin; Behera, Jitendra; Nannicini, Giacomo; Simpson, Robert E

    2016-10-27

    We use an evolutionary algorithm to explore the design space of hexagonal Ge2Sb2Te5; a van der Waals layered two dimensional crystal heterostructure. The Ge2Sb2Te5 structure is more complicated than previously thought. Predominant features include layers of Ge3Sb2Te6 and Ge1Sb2Te4 two dimensional crystals that interact through Te-Te van der Waals bonds. Interestingly, (Ge/Sb)-Te-(Ge/Sb)-Te alternation is a common feature for the most stable structures of each generation's evolution. This emergent rule provides an important structural motif that must be included in the design of high performance Sb2Te3-GeTe van der Waals heterostructure superlattices with interfacial atomic switching capability. The structures predicted by the algorithm agree well with experimental measurements on highly oriented, and single crystal Ge2Sb2Te5 samples. By analysing the evolutionary algorithm optimised structures, we show that diffusive atomic switching is probable by Ge atoms undergoing a transition at the van der Waals interface from layers of Ge3Sb2Te6 to Ge1Sb2Te4 thus producing two blocks of Ge2Sb2Te5. Evolutionary methods present an efficient approach to explore the enormous multi-dimensional design parameter space of van der Waals bonded heterostructure superlattices.

  8. Materials perspective on Casimir and van der Waals interactions

    DOE PAGES

    Woods, L. M.; Dalvit, D. A. R.; Tkatchenko, A.; ...

    2016-11-02

    Interactions induced by electromagnetic fluctuations, such as van der Waals and Casimir forces, are of universal nature present at any length scale between any types of systems. In such interactions these are important not only for the fundamental science of materials behavior, but also for the design and improvement of micro- and nanostructured devices. In the past decade, many new materials have become available, which has stimulated the need for understanding their dispersive interactions. The field of van der Waals and Casimir forces has experienced an impetus in terms of developing novel theoretical and computational methods to provide new insightsmore » into related phenomena. The understanding of such forces has far reaching consequences as it bridges concepts in materials, atomic and molecular physics, condensed-matter physics, high-energy physics, chemistry, and biology. Our review summarizes major breakthroughs and emphasizes the common origin of van der Waals and Casimir interactions. Progress related to novel ab initio modeling approaches and their application in various systems, interactions in materials with Dirac-like spectra, force manipulations through nontrivial boundary conditions, and applications of van der Waals forces in organic and biological matter are examined. Finally, the outlook of the review is to give the scientific community a materials perspective of van der Waals and Casimir phenomena and stimulate the development of experimental techniques and applications.« less

  9. Moment tensor inversion of recent local moderate sized Van Earthquakes: seismicity and active tectonics of the Van region : Eastern Turkey

    NASA Astrophysics Data System (ADS)

    Kalafat, D.; Suvarikli, M.; Ogutcu, Z.; Kekovali, K.; Ocal, M. F.; Gunes, Y.; Pinar, A.

    2013-12-01

    The study area of the present research, the Van Region is located at the norththern end of the collision zone between the Anatolia and Arabian plates. Therefore, the southeast border of the Anatolian plate collides with the Arabian plate along the Bitlis Suture Zone. This zone is formed by collision of Arabian and in large scale Eurasian plates at mid-Miocen age. This type of thrust generation as a result of compressional regime extends east-west. The largest recorded earthquakes have all taken place along Southern Turkey (e.g. Lice, 1971; Varto, 1966; Caldiran, 1976). On the 23th of October 2011, an earthquake shook the Van Lake, Eastern Turkey, following a seismic sequence of more than three months in an unprecedented episode for this region characterized by null or low seismicity. The October 23, 2011 Van-Ercis Earthquake (Mw=7.1) was the most devastating resulting in loss of life and destruction. In order to study the aftershocks' activity of this main event, we installed and kept a seismic network of 10 broad-band (BB) stations in the area for an interval of nearly fifteen months. We characterized the seismogenic structure of the zone by calculating a minimum 1-D local velocity model and obtaining precise hypocentre locations. We also calculated fault plane solutions for more than 200 moderate sized earthquakes based on first motion polarities and commonly Moment Tensor Inversion Methods. The seismogenic zone would be localized at aproximately 10 km depth. Generally, the distribution of the important moderate earthquakes and the aftershock distribution shows that the E-W and NE-SW oriented fault segments cause the earthquake activities. Aftershock events are located along the eastern border of Lake Van and mainly between 5 and 10 km depth and disposed in two alignments: a ~E-W-trending alignment that matches with the trace of the Van Trust fault Zone and a NE-trending which could correspond to an structure not previously seen. Selected focal mechanisms show a

  10. A cartography of the van der Waals territories.

    PubMed

    Alvarez, Santiago

    2013-06-28

    The distribution of distances from atoms of a particular element E to a probe atom X (oxygen in most cases), both bonded and intermolecular non-bonded contacts, has been analyzed. In general, the distribution is characterized by a maximum at short E···X distances corresponding to chemical bonds, followed by a range of unpopulated distances--the van der Waals gap--and a second maximum at longer distances--the van der Waals peak--superimposed on a random distribution function that roughly follows a d(3) dependence. The analysis of more than five million interatomic "non-bonded" distances has led to the proposal of a consistent set of van der Waals radii for most naturally occurring elements, and its applicability to other element pairs has been tested for a set of more than three million data, all of them compared to over one million bond distances.

  11. Van Driest transformation and compressible wall-bounded flows

    NASA Technical Reports Server (NTRS)

    Huang, P. G.; Coleman, G. N.

    1994-01-01

    The transformation validity question utilizing resulting data from direct numerical simulations (DNS) of supersonic, isothermal cold wall channel flow was investigated. The DNS results stood for a wide scope of parameter and were suitable for the purpose of examining the generality of Van Driest transformation. The Van Driest law of the wall can be obtained from the inner-layer similarity arguments. It was demonstrated that the Van Driest transformation cannot be incorporated to collapse the sublayer and log-layer velocity profiles simultaneously. Velocity and temperature predictions according to the preceding composite mixing-length model were presented. Despite satisfactory congruity with the DNS data, the model must be perceived as an engineering guide and not as a rigorous analysis.

  12. In Vivo Characterization of the Activation and Interaction of the VanR-VanS Two-Component Regulatory System Controlling Glycopeptide Antibiotic Resistance in Two Related Streptomyces Species

    PubMed Central

    Novotna, Gabriela Balikova; Kwun, Min Jung

    2015-01-01

    The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide antibiotics in various bacteria. We have performed a comparative study of the VanR-VanS systems from two streptomyces strains, Streptomyces coelicolor and Streptomyces toyocaensis, to characterize how the two proteins cooperate to signal the presence of antibiotics and to define the functional nature of each protein in each strain background. The results indicate that the glycopeptide antibiotic inducer specificity is determined solely by the differences between the amino acid sequences of the VanR-VanS two-component systems present in each strain rather than by any inherent differences in general cell properties, including cell wall structure and biosynthesis. VanR of S. coelicolor (VanRsc) functioned with either sensor kinase partner, while VanR of S. toyocaensis (VanRst) functioned only with its cognate partner, S. toyocaensis VanS (VanSst). In contrast to VanRsc, which is known to be capable of phosphorylation by acetylphosphate, VanRst could not be activated in vivo independently of a VanS sensor kinase. A series of amino acid sequence modifications changing residues in the N-terminal receiver (REC) domain of VanRst to the corresponding residues present in VanRsc failed to create a protein capable of being activated by VanS of S. coelicolor (VanSsc), which suggests that interaction of the response regulator with its cognate sensor kinase may require a region more extended than the REC domain. A T69S amino acid substitution in the REC domain of VanRst produced a strain exhibiting weak constitutive resistance, indicating that this particular amino acid may play a key role for VanS-independent phosphorylation in the response regulator protein. PMID:26711760

  13. Arthur van Gehuchten takes neurology to the movies.

    PubMed

    Aubert, Geneviève

    2002-11-26

    To present the cinematographic production of Arthur Van Gehuchten (1861-1914) and to put this collection into its medical and sociocultural context. The arrival of Edison's Kinetoscope (1891) and Lumière's Cinématographe (1895) provoked the immediate interest of neurologists who foresaw the potential of motion pictures for illustration, research, and teaching. Arthur Van Gehuchten, professor of anatomy and neurology at the Catholic University of Louvain, was trained as a microscopist and a cytologist. From neuroanatomy, he progressively broadened his interest to neurology. Van Gehuchten was an avant-garde teacher, eager to adopt new visual aids. In 1895, he attended the first cinematographic screenings. Medical cinematography was soon brought into disrepute in European academic circles, when films made by the French surgeon Doyen were copied and shown on fairgrounds. Nevertheless, in 1905, Van Gehuchten began to film neurologic patients. He used this technique extensively to demonstrate clinical signs, to illustrate neurologic diseases, and to document functional evolution following surgery. For decades, these films were screened for medical students by Van Gehuchten's successors to the chair of neurology. The original nitrate films (more than 2 hours) have been recently rediscovered. They have been restored by the Royal Belgian Film Archive, where they are the oldest Belgian films. At the beginning of the 20th century, Van Gehuchten built up a collection of moving pictures for teaching purposes. This was one of the first such undertakings. This unique set of films has miraculously survived, and serves as an important archive of nervous diseases and their manifestations prior to the advent of modern therapies.

  14. The Economics of van der Waals Force Engineering

    NASA Astrophysics Data System (ADS)

    Pinto, Fabrizio

    2008-01-01

    As micro-electro-mechanical system (MEMS) fabrication continues on an ever-decreasing scale, new technological challenges must be successfully negotiated if Moore's Law is to be an even approximately valid model of the future of device miniaturization. Among the most significant obstacles is the existence of strong surface forces related to quantum mechanical van der Waals interatomic interactions, which rapidly diverge as the distance between any two neutral boundaries decreases. The van der Waals force is a contributing factor in several device failures and limitations, including, for instance, stiction and oscillator non-linearities. In the last decade, however, it has been conclusively shown that van der Waals forces are not just a MEMS limitation but can be engineered in both magnitude and sign so as to enable classes of proprietary inventions which either deliver novel capabilities or improve upon existing ones. The evolution of van der Waals force research from an almost exclusively theoretical field in quantum-electro-dynamics to an enabling nanotechnology discipline represents a useful example of the ongoing paradigm shift from government-centered to private-capital funded R&D in cutting-edge physics leading to potentially profitable products. In this paper, we discuss the reasons van der Waals force engineering may lead to the creation of thriving markets both in the short and medium terms by highlighting technical challenges that can be competitively addressed by this novel approach. We also discuss some notable obstacles to the cultural transformation of the academic research community required for the emergence of a functional van der Waals force engineering industry worldwide.

  15. 78 FR 47817 - Parts and Accessories Necessary for Safe Operation; Application for an Exemption From Van Hool N...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ...; Application for an Exemption From Van Hool N.V. and Coach USA AGENCY: Federal Motor Carrier Safety... requests public comment on an application for exemption from Van Hool N.V. and Coach USA (Van Hool/Coach...

  16. Van vleck paramagnetism in orthorhombic TiO2 (Brookite)

    USGS Publications Warehouse

    Senftle, F.E.; Thorpe, A.N.

    1968-01-01

    The magnetic susceptibility of the orthorhombic form of titanium dioxide has been measured from 5 to 300??K. After deducting the temperature-dependent component, which is probably due to defects or impurities, and the free-ion diamagnetic component, the Van Vleck paramagnetism was estimated to be 33??10-6 emu/mole. Comparison is made between this value and the Van Vleck paramagnetism of strontium titanate and the two tetragonal forms of titanium dioxide: rutile and anatase. ?? 1968 The American Physical Society.

  17. Effective field theories for van der Waals interactions

    NASA Astrophysics Data System (ADS)

    Brambilla, Nora; Shtabovenko, Vladyslav; Tarrús Castellà, Jaume; Vairo, Antonio

    2017-06-01

    Van der Waals interactions between two neutral but polarizable systems at a separation R much larger than the typical size of the systems are at the core of a broad sweep of contemporary problems in settings ranging from atomic, molecular and condensed matter physics to strong interactions and gravity. In this paper, we reexamine the dispersive van der Waals interactions between two hydrogen atoms. The novelty of the analysis resides in the usage of nonrelativistic effective field theories of quantum electrodynamics. In this framework, the van der Waals potential acquires the meaning of a matching coefficient in an effective field theory, dubbed van der Waals effective field theory, suited to describe the low-energy dynamics of an atom pair. It may be computed systematically as a series in R times some typical atomic scale and in the fine-structure constant α . The van der Waals potential gets short-range contributions and radiative corrections, which we compute in dimensional regularization and renormalize here for the first time. Results are given in d space-time dimensions. One can distinguish among different regimes depending on the relative size between 1 /R and the typical atomic bound-state energy, which is of order m α2. Each regime is characterized by a specific hierarchy of scales and a corresponding tower of effective field theories. The short-distance regime is characterized by 1 /R ≫m α2 and the leading-order van der Waals potential is the London potential. We also compute next-to-next-to-next-to-leading-order corrections. In the long-distance regime we have 1 /R ≪m α2. In this regime, the van der Waals potential contains contact terms, which are parametrically larger than the Casimir-Polder potential that describes the potential at large distances. In the effective field theory, the Casimir-Polder potential counts as a next-to-next-to-next-to-leading-order effect. In the intermediate-distance regime, 1 /R ˜m α2, a significantly more complex

  18. Baseline tests of the Volkswagen transporter electric delivery van

    NASA Technical Reports Server (NTRS)

    Soltis, R. F.; Mcbrien, E. F.; Bozek, J. M.; Gourash, F.

    1978-01-01

    The Volkswagen Transporter, an electric delivery van, was tested as part of an Energy Research and Development Administration (ERDA) project to characterize the state of the art of electric vehicles. The Volkswagen Transporter is a standard Volkswagen van that has been converted to an electric vehicle. It is powered by a 144-volt traction battery. A direct current (dc) chopper controller, actuated by a conventional accelerator pedal, regulates the voltage or power applied to the 16-kilowatt (21-hp) motor. The braking system uses conventional hydraulic braking in combination with an electric regenerative braking system. The Volkswagen vehicle performance test results are presented.

  19. Curves of growth for van der Waals broadened spectral lines

    NASA Technical Reports Server (NTRS)

    Park, C.

    1980-01-01

    Curves of growth are evaluated for a spectral line broadened by the van der Waals interactions during collisions. The growth of the equivalent widths of such lines is shown to be dependent on the product of the perturber density and the 6/10 power of the van der Waals potential coefficient. When the parameter is small, the widths grow as the 1/2 power of the optical depth as they do for the Voigt profile: but when the parameter is large, they grow as 2/3 power and, hence, faster than the Voigt profile. An approximate analytical expression for the computed growth characteristics is given.

  20. NOAA's Van-Based Mobile Atmospheric Emissions Measurement Laboratory

    NASA Astrophysics Data System (ADS)

    Dube, W. P.; Peischl, J.; Neuman, J. A.; Eilerman, S. J.; Holloway, M.; Roberts, O.; Aikin, K. C.; Ryerson, T. B.

    2015-12-01

    The Chemical Science Division (CSD) mobile atmospheric emissions measurement laboratory is the second and latest of two mobile measurement vans outfitted for atmospheric sampling by the NOAA Earth System Research Laboratory. In this presentation we will describe the modifications made to this vehicle to provide a versatile and relatively inexpensive instrument platform including: the 2 kW 120 volt instrument power system; battery back-up system; data acquisition system; real-time display; meteorological, directional, and position sensor package; and the typical atmospheric emissions instrument package. The van conversion uses commercially available, off-the-shelf components from the marine and RV industries, thus keeping the costs quite modest.

  1. Cold Anisotropically Interacting van der Waals Molecule: TiHe.

    PubMed

    Quiros, Nancy; Tariq, Naima; Tscherbul, Timur V; Kłos, Jacek; Weinstein, Jonathan D

    2017-05-26

    We have used laser ablation and helium buffer-gas cooling to produce titanium-helium van der Waals molecules at cryogenic temperatures. The molecules were detected through laser-induced fluorescence spectroscopy. Ground-state Ti(a^{3}F_{2})-He binding energies were determined for the ground and first rotationally excited states from studying equilibrium thermodynamic properties, and found to agree well with theoretical calculations based on newly calculated ab initio Ti-He interaction potentials, opening up novel possibilities for studying the formation, dynamics, and nonuniversal chemistry of van der Waals clusters at low temperatures.

  2. Description of van der Waals interactions using transformation optics.

    PubMed

    Zhao, Rongkuo; Luo, Yu; Fernández-Domínguez, A I; Pendry, J B

    2013-07-19

    Exact calculation of the van der Waals interaction between closely spaced plasmonic nanoparticles is challenging due to the strong concentration of the electromagnetic fields that takes place at the nanometric gap between them. The technique of transformation optics, capable of mapping a small volume into any desired length scale, enables us to shed physical insight into the intricate behavior of electromagnetic fields in extremely small gaps. Using this theoretical tool, we obtain universal analytical expressions for the van der Waals interactions between spherical nanoparticles made of realistic metals at arbitrary separation.

  3. Cold Anisotropically Interacting van der Waals Molecule: TiHe

    NASA Astrophysics Data System (ADS)

    Quiros, Nancy; Tariq, Naima; Tscherbul, Timur V.; Kłos, Jacek; Weinstein, Jonathan D.

    2017-05-01

    We have used laser ablation and helium buffer-gas cooling to produce titanium-helium van der Waals molecules at cryogenic temperatures. The molecules were detected through laser-induced fluorescence spectroscopy. Ground-state Ti (a 3F2)-He binding energies were determined for the ground and first rotationally excited states from studying equilibrium thermodynamic properties, and found to agree well with theoretical calculations based on newly calculated ab initio Ti-He interaction potentials, opening up novel possibilities for studying the formation, dynamics, and nonuniversal chemistry of van der Waals clusters at low temperatures.

  4. Eisen voor Buitenbeelden van Voertuigsimulatoren: Een Literatuurstudie (Use of Exterior Pictures in Vehicle Simulators: A Literature Survey)

    DTIC Science & Technology

    1991-06-01

    afstand van bet traject van bet voertuig (Waidram, 1985), zoals onderbroken wegbelijning of bomen langs, de weg. Voor bet waarnemen van koers en...betroffen het op constante boogte houden en een vaste koers bandbaven bij random verstoringen. Een beeldvertraging van 100 ms zou ook geen belangrijk effect...Voor onderzoek naar, en training van, interacties tussen weggebmuikers is het echter belangrijk omn zowel koers als sneiheid van U6n of meer

  5. Transcriptional regulation of the vanillate utilization genes (vanABK Operon) of Corynebacterium glutamicum by VanR, a PadR-like repressor.

    PubMed

    Morabbi Heravi, Kambiz; Lange, Julian; Watzlawick, Hildegard; Kalinowski, Jörn; Altenbuchner, Josef

    2015-03-01

    Corynebacterium glutamicum is able to utilize vanillate, the product of lignin degradation, as the sole carbon source. The vanillate utilization components are encoded by the vanABK operon. The vanA and vanB genes encode the subunits of vanillate O-demethylase, converting vanillate to protocatechuate, while VanK is the specific vanillate transporter. The vanABK operon is regulated by a PadR-type repressor, VanR. Heterologous gene expression and variations of the vanR open reading frame revealed that the functional VanR contains 192 residues (21 kDa) and forms a dimer, as analyzed by size exclusion chromatography. In vivo, ferulate, vanillin, and vanillate induced PvanABK in C. glutamicum, while only vanillate induced the activity of PvanABK in Escherichia coli lacking the ferulate catabolic system. Differential scanning fluorimetry verified that vanillate is the only effector of VanR. Interaction between the PvanABK DNA fragment and the VanR protein had an equilibrium dissociation constant (KD) of 15.1 ± 1.7 nM. The VanR-DNA complex had a dissociation rate constant (Kd) of (267 ± 23) × 10(-6) s(-1), with a half-life of 43.5 ± 3.6 min. DNase I footprinting localized the VanR binding site at PvanABK, extending from +9 to +45 on the coding strand. Deletion of the nucleotides +18 to +27 inside the VanR binding site rendered PvanABK constitutive. Fusion of the T7 promoter and the wild-type VanR operator, as well as its shortened versions, indicated that the inverted repeat AACTAACTAA(N4)TTAGGTATTT is the specific VanR binding site. It is proposed that the VanR-DNA complex contains two VanR dimers at the VanR operator. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  6. Conversion of Chemical Reaction Energy into Useful Work in the Van't Hoff Equilibrium Box

    ERIC Educational Resources Information Center

    Bazhin, N. M.; Parmon, V. N.

    2007-01-01

    The ideal van't Hoff equilibrium box is described in detail. It shows that van't Hoff equilibrium box divided in two parts can simultaneously produce heat and useful work without violation of the first law of thermodynamics.

  7. Twelve-Month Evaluation of UPS Diesel Hybrid Electric Delivery Vans

    SciTech Connect

    Lammert, M.

    2009-12-01

    Results of an NREL study of a parallel hybrid electric-diesel propulsion system in United Parcel Service-operated delivery vans show that the hybrids had higher fuel economy than standard diesel vans.

  8. Conversion of Chemical Reaction Energy into Useful Work in the Van't Hoff Equilibrium Box

    ERIC Educational Resources Information Center

    Bazhin, N. M.; Parmon, V. N.

    2007-01-01

    The ideal van't Hoff equilibrium box is described in detail. It shows that van't Hoff equilibrium box divided in two parts can simultaneously produce heat and useful work without violation of the first law of thermodynamics.

  9. 77 FR 54646 - Culturally Significant Objects Imported for Exhibition Determinations: “Becoming Van Gogh”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... Imported for Exhibition Determinations: ``Becoming Van Gogh'' SUMMARY: Notice is hereby given of the... objects to be included in the exhibition ``Becoming Van Gogh,'' imported from abroad for temporary...

  10. VanA and VanB Positive Vancomycin-resistant Staphylococcus aureus Among Clinical Isolates in Shiraz, South of Iran

    PubMed Central

    Saadat, Sareh; Solhjoo, Kavous; Norooz-Nejad, Mohammad-Javad; Kazemi, Akbar

    2014-01-01

    Objective The purpose of this study was to determine the prevalence of vancomycin-resistant Staphylococcus aureus isolated from clinical samples in Shiraz hospitals. Methods From March to December 2012, 100 S. aureus isolates (mainly from wound and blood) were collected from three hospitals in Shiraz, south of Iran. After identification of Staphylococcus aureus by biochemical, microbiological and molecular methods, antibiotic susceptibility testing was performed by Kirby-Bauer disc diffusion test for 13 different antibiotics. Vancomycin-resistant Staphylococcus aureus isolates were determined by vancomycin agar screening test and PCR for vancomycin resistant genes (vanA and vanB). Results The lowest and highest resistance was seen for quinupristin-dalfopristin (n=1) and ampicillin (n=95), respectively. Vancomycin agar screening test showed that 37 isolates can grow on these media. Further study by PCR also detected vanA and/or vanB genes in all of these strains. Also, 19 isolates showed either vanA or vanB but were susceptible according to vancomycin agar screening test. In total, vanA and vanB resistant genes were detected in 34% and 37% of clinical isolates, respectively. Conclusion The results showed that the frequency of vancomycin resistance genes (vanA, vanB) is very high in Staphylococcus aureus strains isolated from patients in south of Iran. Thus, urgent interventions are needed to keep the emergence and transmission of these isolates to a minimum. PMID:25337309

  11. Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile.

    PubMed

    Peltier, Johann; Courtin, Pascal; El Meouche, Imane; Catel-Ferreira, Manuella; Chapot-Chartier, Marie-Pierre; Lemée, Ludovic; Pons, Jean-Louis

    2013-07-01

    Primary antibiotic treatment of Clostridium difficile intestinal diseases requires metronidazole or vancomycin therapy. A cluster of genes homologous to enterococcal glycopeptides resistance vanG genes was found in the genome of C. difficile 630, although this strain remains sensitive to vancomycin. This vanG-like gene cluster was found to consist of five ORFs: the regulatory region consisting of vanR and vanS and the effector region consisting of vanG, vanXY and vanT. We found that 57 out of 83 C. difficile strains, representative of the main lineages of the species, harbour this vanG-like cluster. The cluster is expressed as an operon and, when present, is found at the same genomic location in all strains. The vanG, vanXY and vanT homologues in C. difficile 630 are co-transcribed and expressed to a low level throughout the growth phases in the absence of vancomycin. Conversely, the expression of these genes is strongly induced in the presence of subinhibitory concentrations of vancomycin, indicating that the vanG-like operon is functional at the transcriptional level in C. difficile. Hydrophilic interaction liquid chromatography (HILIC-HPLC) and MS analysis of cytoplasmic peptidoglycan precursors of C. difficile 630 grown without vancomycin revealed the exclusive presence of a UDP-MurNAc-pentapeptide with an alanine at the C terminus. UDP-MurNAc-pentapeptide [d-Ala] was also the only peptidoglycan precursor detected in C. difficile grown in the presence of vancomycin, corroborating the lack of vancomycin resistance. Peptidoglycan structures of a vanG-like mutant strain and of a strain lacking the vanG-like cluster did not differ from the C. difficile 630 strain, indicating that the vanG-like cluster also has no impact on cell-wall composition.

  12. Experimental Testing of a Van De Graaff Generator as an Electromagnetic Pulse Generator

    DTIC Science & Technology

    2016-07-01

    EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR THESIS...protection in the United States AFIT-ENP-MS-16-S-075 EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR...RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENP-MS-16-S-075 EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR

  13. Storings analyse Ten Behoeve van het Materieelverzorgingsplan (Failure Analysis for the Maintenance Plan)

    DTIC Science & Technology

    1990-05-01

    van kwantitatieve normen voor logistieke parameters, op grond waarvan de logistieke ondersteuning ontworpen moet worden. Binnen ILS wordt de logistieke...ondersteuning zodanig ingericht dat aan van tevoren vastgestelde kwantitatieve normen voor bescbikbaarheid, inzetbaarheid, betrouwbaarbeid en...9] ’Richtlijnen ten aanzien van het materieelverzorgingsplan’. Deze docuinenten geven de uitgangspunten en normen die de opsteller in acht moet nemen

  14. Ellis–Van Creveld syndrome in siblings: A rare case report

    PubMed Central

    Gokulraj, Sabitha; Mohan, N.; Raj, J. Babususai; Ahamed, S. Yasmeen; Arokiaraj, C. J. Stephen; Subbulakshmi, A. Cicilia

    2016-01-01

    Ellis–Van Creveld syndrome or chondroectodermal dysplasia is a rare autosomal recessive disorder presenting several skeletal manifestations and congenital heart malformations. Ellis–Van Creveld syndrome comprises of a tetrad of clinical manifestations of chondrodysplasia, polydactyly, ectodermal dysplasia, and cardiac defects. Here, we are presenting a very rare case of Ellis–Van Creveld syndrome in siblings. PMID:27829775

  15. View west along Lower Raceway, Van Houten Street, with (left ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View west along Lower Raceway, Van Houten Street, with (left to right) Congdon Mill, Phoenix Mill, and Fabricolor Mill (a.k.a., Industry Mill, HAER No. NJ-15) - Great Falls/S. U. M. Power Canal System, Paterson, Passaic County, NJ

  16. Van der Waals forces in pNRQED

    SciTech Connect

    Shtabovenko, Vladyslav

    2016-01-22

    We report on the calculation of electromagnetic van der Waals forces [1] between two hydrogen atoms using non-relativistic effective field theories (EFTs) of QED for large and small momentum transfers with respect to the intrinsic energy scale of the hydrogen atom. Our results reproduce the well known London and Casimir-Polder forces.

  17. 76 FR 13192 - Mark E. Van Wormer: Debarment Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... BOTOX for use in treatment of forehead wrinkles. However, during that time he knowingly used TRI-toxin, an unapproved botulinum toxin type A product, that he purchased from Toxin Research International, Inc. (TRI), a company in Tucson, AZ. Dr. Van Wormer purchased approximately 20 vials of the TRI-toxin...

  18. The Evaluation of the Parameters in the van Deemter Equation.

    ERIC Educational Resources Information Center

    Moody, Harvey W.

    1982-01-01

    Describes experiment expanding on principles behind measuring efficiency of chromatographic columns and allowing calculation of parameters in the van Deemter equation. Easily accomplished in a three-hour period using a gas chromatograph in which gas flow can be changed and measured. Mathematical solutions can be attained with programmable…

  19. Heath Van Essen - Clean Water Act Public Notice

    EPA Pesticide Factsheets

    The EPA is providing notice of a proposed Administrative Penalty Assessment against Heath Van Essen, Respondent, an individual who owns or operates an animal feeding operation (“Facility”) that is located in Section 27 of Township 98 North, Range 47 West,

  20. Van Allen Probes Science Gateway: A Centralized Data Access Point

    NASA Astrophysics Data System (ADS)

    Romeo, G.; Barnes, R. J.; Ukhorskiy, A. Y.; Sotirelis, T.; Stephens, G. K.; Kessel, R.; Potter, M.

    2015-12-01

    The Van Allen Probes Science Gateway acts a centralized interface to the instrument Science Operation Centers (SOCs), provides mission planning tools, and hosts a number of science related activities such as the mission bibliography. Most importantly, the Gateway acts as the primary site for processing and delivering the Van Allen Probes Space Weather data to users. Over the past years, the web-site has been completely redesigned with the focus on easier navigation and improvements of the existing tools such as the orbit plotter, position calculator and magnetic footprint tool. In addition, a new data plotting facility has been added. Based on HTML5, which allows users to interactively plot Van Allen Probes science and space weather data. The user can tailor the tool to display exactly the plot they wish to see and then share this with other users via either a URL or by QR code. Various types of plots can be created, including, simple time series, data plotted as a function of orbital location, and time versus L-Shell, capability of visualizing data from both probes (A & B) on the same plot. In cooperation with all Van Allen Probes Instrument SOCs, the Science Gateway will soon be able to serve higher level data products (Level 3), and to visualize them via the above mentioned HTML5 interface. Users will also be able to create customized CDF files on the fly.

  1. Statistical complexity, virial expansion, and van der Waals equation

    NASA Astrophysics Data System (ADS)

    Pennini, F.; Plastino, A.

    2016-09-01

    We investigate the notion of LMC statistical complexity with regards to a real gas and in terms of the second virial coefficient. The ensuing results are applied to the van der Waals equation. Interestingly enough, one finds a complexity-interpretation for the associated phase transition.

  2. Oral abnormalities in the Ellis-van Creveld syndrome.

    PubMed

    Babaji, Prashant

    2010-01-01

    Ellis-van Creveld (EvC) syndrome is an autosomal recessive disorder, mainly affecting the ectodermal components such as, enamel, nail, and hair. The gene for EvC syndrome is located on chromosome 4p16. Patients with EvC syndrome characteristically presents with congenitally missing teeth, abnormal frenal attachment, microdontia, and hexadactyly.

  3. Aldo van Eyck's Playgrounds: Aesthetics, Affordances, and Creativity.

    PubMed

    Withagen, Rob; Caljouw, Simone R

    2017-01-01

    After World War II, the Dutch architect Aldo van Eyck developed hundreds of playgrounds in the city of Amsterdam. These public playgrounds were located in parks, squares, and derelict sites, and consisted of minimalistic aesthetic play equipment that was supposed to stimulate the creativity of children. Over the last decades, these playgrounds have been studied by sociologists, theorists of art and architecture, and psychologists. Adopting an ecological approach to the human environment, it is argued that the abstract forms of van Eyck's play sculptures indeed stimulate the creativity of the child. Whereas a slide or a swing almost dictates what a child is supposed to do, van Eyck's play equipment invites the child to actively explore the numerous affordances (action possibilities) it provided. However, it is argued that the standardization (e.g., equal distances between blocks or bars) that tends to characterize van Eyck' play equipment has negative effects on the playability. This standardization, which was arguably the result of the aesthetic motives of the designer, might be appealing to children when simply looking at the equipment, but it is not of overriding importance to them when playing in it. Indeed, a recent study indicates that the affordances provided by messy structures appear to have a greater appeal to playing children.

  4. Nonadiabatic corrections to the van der Waals potential

    NASA Technical Reports Server (NTRS)

    Au, C. K.

    1988-01-01

    Closed-form expressions are derived for the finite-mass nonadiabatic corrections to the van der Waals potential in the electric-dipole approximations in terms of London-analog two-center atomic spectral sums. The nonadiabatic corrections to all orders at threshold energy and also those with first-order energy dependence are given.

  5. PIXE facility at Jordan Van-de-Graaff accelerator

    SciTech Connect

    Saleh, N.; Hallak, A.; Al-Saleh, K.; Arafah, D.E.

    1986-01-01

    Particle Induced X-ray Emission (PIXE) set-up was constructed and optimized for routine elemental analysis at the University of Jordan Van de Graaff accelerator (JOVAC). Some important features of the system are described. Testing was carried out using some standards. Applications to Jordanian currencies are discussed.

  6. Van Vleck from Spectroscopy to Susceptibilities: Kuhn Losses Regained

    NASA Astrophysics Data System (ADS)

    Janssen, Michel

    2011-03-01

    As a young assistant professor in Minneapolis, John H. Van Vleck spent much of his time between 1923 and 1926 writing a book-length Bulletin for the National Research Council. As its title, Quantum Principles and Line Spectra, suggests, the book focuses almost exclusively on spectroscopy, the core pursuit of the old quantum theory. By the time it finally appeared in 1926, the old quantum theory had given way to the new quantum mechanics. Van Vleck soon realized that matrix mechanics reinstated some well-confirmed results of the classical theory of susceptibilities that had been lost in the old quantum theory. In the history and philosophy of science literature, such losses are called 'Kuhn losses'. Using mathematical techniques similar to those presented in his NRC Bulletin, Van Vleck started to work on the theory of susceptibilities. In 1929, now a full professor in Madison, he began writing another book, which appeared in 1932 and has become a classic: The Theory of Electric and Magnetic Susceptibilities. In this talk I follow Van Vleck's trajectory from spectroscopy to susceptibilities and examine how his two books reflect and helped shape research traditions.The talk is based on joint work with Charles Midwinter.

  7. Wnt signalling: a moving picture emerges from van gogh.

    PubMed

    Heisenberg, Carl-Philipp; Tada, Masazumi

    2002-02-19

    Recent studies on vertebrate homologues of the van gogh/strabismus (vang/stbm) gene, a key player in planar cell polarity signalling in Drosophila, show that vang/stbm is involved in patterning and morphogenesis during vertebrate gastrulation where it modulates two distinct Wnt signals.

  8. Letters from a suicide: Van Gogh and his sister.

    PubMed

    Lester, David

    2010-04-01

    An analysis of trends over a 3-yr. period in the letters of Vincent Van Gogh to his sister as the time of his suicide approached identified 8 trends, including an increase in words concerned with anxiety and words concerned with the past.

  9. Research at the BNL Tandem Van de Graaff Facility, 1980

    SciTech Connect

    Not Available

    1981-03-01

    Research programs at the Brookhaven Van de Graaff accelerators are summarized. Major accomplishments of the laboratory are discussed including quasielastic reactions, high-spin spectroscopy, yrast spectra, fusion reactions, and atomic physics. The outside user program at the Laboratory is discussed. Research proposed for 1981 is outlined. (GHT)

  10. Excited nucleon as a van der Waals system of partons

    SciTech Connect

    Jenkovszky, L. L.; Muskeyev, A. O. Yezhov, S. N.

    2012-06-15

    Saturation in deep inelastic scattering (DIS) and deeply virtual Compton scattering (DVCS) is associated with a phase transition between the partonic gas, typical of moderate x and Q{sup 2}, and partonic fluid appearing at increasing Q{sup 2} and decreasing Bjorken x. We suggest the van der Waals equation of state to describe properly this phase transition.

  11. James Van Allen and His Namesake NASA Mission

    NASA Astrophysics Data System (ADS)

    Baker, D. N.; Hoxie, V. C.; Jaynes, A.; Kale, A.; Kanekal, S. G.; Li, X.; Reeves, G. D.; Spence, H. E.

    2013-12-01

    In many ways, James A. Van Allen defined and "invented" modern space research. His example showed the way for government-university partners to pursue basic research that also served important national and international goals. He was a tireless advocate for space exploration and for the role of space science in the spectrum of national priorities.

  12. A. E. van Vogt's "Unreality" and Formula Writing.

    ERIC Educational Resources Information Center

    Drake, H. L.

    A. E. van Vogt's theory of "unreality" explains in part how he has become so prolific in a literary genre--science fiction/science fantasy--which only recently has experienced a rise in popularity. His theory states that the science fictional sentence must have in it something that requires a contribution from the reader. If the author…

  13. 1. Photocopy of woodengraving by Van Vleck & Keith from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of wood-engraving by Van Vleck & Keith from a photograph by Shireff of Higgins' Daguerrian Rooms, Sacramento, with figures, etc. touched up by Nahl & Brothers. Illustration from The Californian Farmer, July 4, 1862. STANFORD HOUSE BY SETH BABSON, VIEW FROM THE NORTHEAST - Leland Stanford House, 800 N Street, Sacramento, Sacramento County, CA

  14. Asteroid 4296 Van Woerkom: A Newly Discovered Asynchronous Binary

    NASA Astrophysics Data System (ADS)

    Odden, Caroline E.; Caso, Maria; Dettorre, Christopher; Dial, Preston J.; Hoang, Kaitlin; Lazar, Travor T.; Morss, Paige P.; Mundra, Akshay R.; Naiyapatana, Abhichana; Rooney, Morgan; Pravec, Petr; Benishek, Vladimir; Klinglesmith, Dan; Pilcher, Frederick

    2017-07-01

    We report that asteroid 4296 van Woerkom is a binary asteroid. Lightcurve analysis for images taken from 2016 November through December reveals a primary rotational period of 2.80868 ± 0.00005 h and a secondary orbital period of 26.22 ± 0.01 h.

  15. The Evolving Space Weather System—Van Allen Probes Contribution

    NASA Astrophysics Data System (ADS)

    Zanetti, L. J.; Mauk, B. H.; Fox, N. J.; Barnes, R. J.; Weiss, M.; Sotirelis, T. S.; Raouafi, N.-E.; Kessel, R. L.; Becker, H. N.

    2014-10-01

    The overarching goal and purpose of the study of space weather is clear—to understand and address the issues caused by solar disturbances on humans and technological systems. Space weather has evolved in the past few decades from a collection of concerned agencies and researchers to a critical function of the National Weather Service of NOAA. The general effects have also evolved from the well-known telegraph disruptions of the mid-1800s to modern day disturbances of the electric power grid, communications and navigation, human spaceflight and spacecraft systems. The last two items in this list, and specifically the effects of penetrating radiation, were the impetus for the space weather broadcast implemented on NASA's Van Allen Probes' twin pair of satellites, launched in August of 2012 and orbiting directly through Earth's severe radiation belts. The Van Allen Probes mission, formerly the Radiation Belt Storm Probes (RBSP), was renamed soon after launch to honor the discoverer of Earth's radiation belts at the beginning of the space age, the late James Van Allen (the spacecraft themselves are still referred to as RBSP-A and RBSP-B). The Van Allen Probes are one part of NASA's Living With a Star program formulated to advance the scientific understanding of the connection between solar disturbances, the resulting heliospheric conditions, and their effects on the geospace and Earth environment.

  16. MTR BASEMENT. WORKERS (DON ALVORD AND CYRIL VAN ORDEN OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR BASEMENT. WORKERS (DON ALVORD AND CYRIL VAN ORDEN OF PHILLIPS PETROLEUM CO.) POSE FOR GAMMA IRRADIATION EXPERIMENT IN MTR CANAL. CANS OF FOOD WILL BE LOWERED TO CANAL BOTTOM, WHERE SPENT MTR FUEL ELEMENTS EMIT GAMMA RADIATION. INL NEGATIVE NO. 11746. Unknown Photographer, 8/20/1954 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  17. 17. Photocopy of photograph (from collection of Charles van Ravenswaay) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy of photograph (from collection of Charles van Ravenswaay) Photographer unknown, ca. 1870 WEST FRONT, TAKEN FROM STEEPLE OF PRESBYTERIAN CHURCH DIRECTLY ACROSS MAIN STREET. TO RIGHT OF THESPIAN HALL, FACING ON VINE STREET, IS BAPTIST CHURCH WITH ORIGINAL STEEPLE - Thespian Hall, Fifth & Vine Streets, Boonville, Cooper County, MO

  18. Aldo van Eyck’s Playgrounds: Aesthetics, Affordances, and Creativity

    PubMed Central

    Withagen, Rob; Caljouw, Simone R.

    2017-01-01

    After World War II, the Dutch architect Aldo van Eyck developed hundreds of playgrounds in the city of Amsterdam. These public playgrounds were located in parks, squares, and derelict sites, and consisted of minimalistic aesthetic play equipment that was supposed to stimulate the creativity of children. Over the last decades, these playgrounds have been studied by sociologists, theorists of art and architecture, and psychologists. Adopting an ecological approach to the human environment, it is argued that the abstract forms of van Eyck’s play sculptures indeed stimulate the creativity of the child. Whereas a slide or a swing almost dictates what a child is supposed to do, van Eyck’s play equipment invites the child to actively explore the numerous affordances (action possibilities) it provided. However, it is argued that the standardization (e.g., equal distances between blocks or bars) that tends to characterize van Eyck’ play equipment has negative effects on the playability. This standardization, which was arguably the result of the aesthetic motives of the designer, might be appealing to children when simply looking at the equipment, but it is not of overriding importance to them when playing in it. Indeed, a recent study indicates that the affordances provided by messy structures appear to have a greater appeal to playing children. PMID:28725208

  19. [Interview with Professor Reinhilde Jacobs. Interview by Th van Nuijs].

    PubMed

    Jacobs, Reinhilde

    2007-01-01

    Th. van Nuijs, chief editor of the Revue Belge de Médecine Dentaire, interviews professor Reinhilde Jacobs. R. Jacobs is professor of dento-maxillo-facial radiology and radioprotection at the Catholic University of Leuven. She is also head of the Oral Imaging Centre at the same university.

  20. 46 CFR 194.10-15 - Magazine van construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Magazine van construction. 194.10-15 Section 194.10-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS HANDLING, USE, AND CONTROL OF EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Magazines § 194.10-15 Magazine...

  1. 46 CFR 194.10-15 - Magazine van construction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Magazine van construction. 194.10-15 Section 194.10-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS HANDLING, USE, AND CONTROL OF EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Magazines § 194.10-15 Magazine...

  2. 46 CFR 194.10-15 - Magazine van construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Magazine van construction. 194.10-15 Section 194.10-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS HANDLING, USE, AND CONTROL OF EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Magazines § 194.10-15 Magazine...

  3. 46 CFR 194.10-15 - Magazine van construction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Magazine van construction. 194.10-15 Section 194.10-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS HANDLING, USE, AND CONTROL OF EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Magazines § 194.10-15 Magazine...

  4. 46 CFR 194.10-15 - Magazine van construction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Magazine van construction. 194.10-15 Section 194.10-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS HANDLING, USE, AND CONTROL OF EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Magazines § 194.10-15 Magazine...

  5. Evolution of alkaline lakes - Lake Van case study

    NASA Astrophysics Data System (ADS)

    Tillman Meyer, Felix; Viehberg, Finn; Bahroun, Sonya; Wolf, Annabel; Immenhauser, Adrian; Kwiecien, Ola

    2017-04-01

    Lake Van in Eastern Anatolia (Turkey) is the largest terminal soda lake on Earth. The lake sedimentary profile covers ca. 600 ka (Stockhecke et al. 2014) Based on lithological changes, the presence of freshwater microfossils and close-to-freshwater pH value in the pore water, members of ICDP PALEOVAN concluded that Lake Van might have started as an open lake. Here we show paleontological and geochemical evidence in favour of this idea and constrain the time, when Lake Van likely transformed into a closed lake. Additionally we provide the first conceptual model of how this closure may have happened. Our archives of choice are inorganic and biogenic carbonates, separated by wet sieving. We identified microfossil assemblages (fraction > 125 µm) and performed high-resolution oxygen isotope (delta18O) and elemental (Mg/Ca, Sr/Ca) analyses of the fraction < 63 µm assuming that it represents only carbonates precipitating in the water column. Microfossil assemblage consists of three different species of ostracods (Candona spp, Loxoconcha sp, Amnicythere spp.), diatoms, gastropods and bivalves. Brakish-water ostracods, Loxoconcha sp and Amnicythere sp occur more often after 530 ka. Additionaly, Loxoconcha sp is a shallow-water species relaying on plants growing in the photic zone as food supply. These two aspects point to an increasing salinity in a shallowing lake. The delta18O values of inorganic carbonates are relatively low during the initial phase of Lake Van and increase abruptly (ca. 7‰) after 530 ka BP. At approximately the same time combination of Sr/Ca and Mg/Ca data suggest first occurrence of aragonite. Again, these findings suggest geochemical changes of the lake water concurrent with transition documented by microfossils. Comparison between Lake Van and Lake Ohrid (Lacey et al. 2016) delta18O data, precludes regional climate change (e.g.: increased evaporation) as the main driver of observed changes. With no evidence for increased volcanic or tectonic

  6. Did Van Gogh have Ménière's disease?

    PubMed

    Martin, C

    2011-09-01

    Very surprising diagnoses have sometimes been made of the illness from which Vincent van Gogh suffered. Most of them can be safely ignored; the diagnosis of Ménière's disease, however, put forward by K. I. Arenberg, deserves attention. This diagnosis was first criticized in a doctoral thesis in 1992 in the university of Saint-Etienne (France), and again in a book published by Henri André Martin in 1994, and the present study is based on these. Analyzing van Gogh's pathology presupposes awareness of the family context in which he lived, his eventful life, his artistic career and of his correspondence, which notably provides no support for a diagnosis of Ménière's disease. Analysis, indeed, enables Ménière's disease to be categorically eliminated in favor of temporal epilepsy, as confirmed in 1956 by Gastaut following the diagnosis initially made half a century earlier by Dr Rey. Van Gogh's illness is an example of the contradictory changes in affect, behavior and personality to be observed in epileptic patients. Absinth intoxication doubtless aggravated van Gogh's epilepsy and may account for certain prolonged episodes of confusion. It would be wrong, however, to speak of alcoholic dementia rather than of a probable epileptic psychosis or other pathology such as hallucinatory psychosis, or delirious attack, either isolated or related to late-onset schizophrenia. Apart from certain episodes of severe mental disorder, however, van Gogh's exceptional creativity was maintained up to the very end. Like any other artist, his temperament was expressed in his art, exalted rather than impaired by his illness. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  7. Detection of seasonal asymptomatic dermatophytes in Van cats

    PubMed Central

    Ilhan, Ziya; Karaca, Mehmet; Ekin, Ismail Hakki; Solmaz, Hasan; Akkan, Hasan Altan; Tutuncu, Mehmet

    2016-01-01

    The Van cat is a domestic landrace found in the Van province of eastern Turkey. In this study, we aimed to determine the seasonal carriage of dermatophytes in Van cats without clinical lesions. A total of 264 hair specimens were collected from clinically healthy cats in and around the Van Province. Of these samples, 30.3% were obtained in spring, 30.6% in summer, 16.6% in autumn, and 22.3% in winter; 45.1% of samples were from male cats and the rest from female ones. Of the studied cats, 118 were younger than 1 year, 78 were 1–3 years old, and 68 were older than 3 years. The specimens were subjected to direct microscopic examination with 15% potassium hydroxide and cultured on Sabouraud dextrose agar and dermatophyte test medium supplemented with cycloheximide and chloramphenicol. Dermatophyte identification was carried out based on macroscopic and microscopic colony morphology, urease activities, in vitro hair perforation test, growth at 37 °C, and pigmentation on corn meal agar. Dermatophytes were isolated from 19 (7.1%) of the 264 specimens examined. The most frequently isolated fungi were Trichophyton terrestre (4.1%), followed by Microsporum gypseum (1.1%), M. nanum (1.1%), and T. mentagrophytes (0.7%), and these fungi may represent a health risk for humans in contact with clinically healthy Van cats. M. canis was not isolated from any of the specimens. Our results show no significant (p > 0.05) association between carriage of dermatophytes and the gender of cats. The carriage rate of dermatophytes was high in spring and winter, and the only possible risk factor for infection was age of the animal. PMID:26887249

  8. Bewegingshinder van Impactbeschermingsmiddelen voor de ME van de KMar (Restriction of Movement of Impact Protective Clothing for the Anti-Riot Squad of the Dutch Military Police)

    DTIC Science & Technology

    2007-12-01

    impactbeschermingsmiddelen voor de ME van de KMar Resultaten van ergonomi etesten die uitgevoerd zijn met irnpactbeschermingsmiddelen...testen van fysieke ergonomie bestaat voor deze kledingpakketten, heeft bet KPU-bedrijf TNO gevraagd hiernaar onderzoek te doen. TNO heeft al vaker voor...testen: ’V-Top’ en ’KLPD nieuwe kleding’. TNO heeft verschillende testen uitgevoerd om de kledingpakketten te beoordelen op fysieke ergonomie . TNO

  9. Obituary: Thomas C. Van Flandern (1940-2009)

    NASA Astrophysics Data System (ADS)

    Dunham, David; Slabinski, Victor

    2011-12-01

    Dr. Thomas Charles Van Flandern, an expert in celestial mechanics and cosmology, died January 9, 2009 in Seattle, Washington, of colon cancer. He was 68. Van Flandern was an astronomer at the U.S. Naval Observatory from 1963 to 1983. He developed software to predict and analyze lunar occultations to improve lunar orbital and fundamental star catalog data. In later years he championed increasingly controversial theories. But his 1978 prediction that some asteroids have natural satellites, which was almost universally rejected, was verified when the Galileo spacecraft photographed Dactyl, a satellite of (243) Ida, during its flyby in 1993. Besides astronomy and computers, he had strong interests in biochemistry and nutrition, and he ran a business selling personal computers in the 1980s. Tom Van Flandern was born June 26, 1940 in Cleveland, Ohio, the first child of Robert F. Van Flandern and Anna Mary Haley. His father, a police officer, left the family when Tom Van Flandern was 5. His mother died when he was 16; he and his siblings then lived with their grandmother, Margery Jobe, until he went to college. Tom Van Flandern became interested in astronomy as a child. He used his first telescope, purchased with newspaper delivery earnings, to observe lunar occultations, and then learned how to predict them, sparking a life-long passion for dynamical astronomy. While attending St. Ignatius High School, Van Flandern and fellow student Thomas Petrie organized the Cleveland Moonwatch team to observe the first artificial satellites, the only team without an adult organizer. In 1958, Tom Van Flandern entered Xavier University where he led the Cincinnati Moonwatch team. He learned computer programming at a summer job with General Electric and wrote software to calculate "look angles" from orbital elements. The Cincinnati team became a top producer of observations using these predictions. Tom obtained a B.S. in mathematics from Xavier in 1962. He spent the next year at

  10. Obituary: Leon Van Speybroeck, 1935-2002

    NASA Astrophysics Data System (ADS)

    Gorenstein, Paul; Tananbaum, Harvey Dale

    2003-12-01

    Leon Van Speybroeck, a master designer of X-ray telescope mirrors and the telescope scientist for the Chandra X-ray Observatory, died in Newton, Massachusetts, on 25 December 2002, shortly after learning that he had metastatic melanoma. Leon was born on 27 August 1935 in Wichita, Kansas. His father, Paul, was Assistant Treasurer and head of the accounting department at Beech Aircraft, and his mother, Anna Florence (Utley), was a homemaker. Both parents died in 1996. Leon's younger sister, Saundra, is a nurse and his younger brother, John, is a surgeon. Leon received a BS in 1957 and a PhD in 1965, both in physics, from MIT. His PhD thesis, ``Elastic Electron-Deuteron Scattering at High Momentum Transfer," was carried out under the supervision of Henry Kendall and Jerome Friedman. Leon spent two more years at MIT as a research associate. In 1967, he was hired by American Science and Engineering (AS&E) in Cambridge, Massachusetts, and joined the X-ray astronomy group led by Riccardo Giacconi, who received the 2002 Nobel Prize in Physics for contributions to astrophysics that led to the discovery of cosmic X-ray sources. Leon soon became involved in the design and construction of high-resolution, grazing-incidence X-ray telescopes, starting with the Apollo Telescope Mount flown on NASA's Skylab from 1973 to 1974. A series of high-resolution X-ray images of the solar corona led to dramatic changes in ideas about the solar corona, with new emphasis on magnetic dynamo processes. When the Smithsonian Astrophysical Observatory and the Harvard College Observatory morphed into the Harvard-Smithsonian Center for Astrophysics (CfA) in 1973, Leon, with Giacconi and other senior X-ray astronomers from AS&E, joined the CfA and formed the high-energy astrophysics division. Leon guided the design and development of the X-ray mirrors on NASA's Einstein Observatory, which was flown from 1978 to 1981 as the first cosmic X-ray observatory with an imaging telescope. Along the way, he

  11. The phosphotransferase VanU represses expression of four qrr genes antagonizing VanO-mediated quorum-sensing regulation in Vibrio anguillarum

    PubMed Central

    Weber, Barbara; Lindell, Kristoffer; El Qaidi, Samir; Hjerde, Erik; Willassen, Nils-Peder

    2011-01-01

    Vibrio anguillarum utilizes quorum sensing to regulate stress responses required for survival in the aquatic environment. Like other Vibrio species, V. anguillarum contains the gene qrr1, which encodes the ancestral quorum regulatory RNA Qrr1, and phosphorelay quorum-sensing systems that modulate the expression of small regulatory RNAs (sRNAs) that destabilize mRNA encoding the transcriptional regulator VanT. In this study, three additional Qrr sRNAs were identified. All four sRNAs were positively regulated by σ54 and the σ54-dependent response regulator VanO, and showed a redundant activity. The Qrr sRNAs, together with the RNA chaperone Hfq, destabilized vanT mRNA and modulated expression of VanT-regulated genes. Unexpectedly, expression of all four qrr genes peaked at high cell density, and exogenously added N-acylhomoserine lactone molecules induced expression of the qrr genes at low cell density. The phosphotransferase VanU, which phosphorylates and activates VanO, repressed expression of the Qrr sRNAs and stabilized vanT mRNA. A model is presented proposing that VanU acts as a branch point, aiding cross-regulation between two independent phosphorelay systems that activate or repress expression of the Qrr sRNAs, giving flexibility and precision in modulating VanT expression and inducing a quorum-sensing response to stresses found in a constantly changing aquatic environment. PMID:21948044

  12. Optics of the ozone lidar ELSA

    NASA Technical Reports Server (NTRS)

    Porteneuve, J.

    1992-01-01

    In order to study the ozone layer in the Arctic, we have to define a new optical concept for a lidar. It was necessary to build a transportable system with a large collecting surface in a minimum of volume. It was too useful to have a multichannel receptor. A description of the Emettor Receptor System, collecting system, and analysis system is provided.

  13. ELSA- The European Levitated Spherical Actruator

    NASA Astrophysics Data System (ADS)

    Ruiz, M.; Serin, J.; Telteu-Nedelcu, D.; De La Vallee Poussin, H.; Onillon, E.; Rossini, L.

    2014-08-01

    The reaction sphere is a magnetic bearing spherical actuator consisting of a permanent magnet spherical rotor that can be accelerated in any direction. It consists of an 8-pole permanent magnet spherical rotor that is magnetically levitated and can be accelerated about any axis by a 20-pole stator with electromagnets. The spherical actuator is proposed as a potential alternative to traditional momentum exchange devices such as reaction wheels (RWs) or control moment gyroscopes (CMGs). This new actuator provides several benefits such as reduced mass and power supply allocated to the attitude and navigation unit, performance gain, and improved reliability due to the absence of mechanical bearings. The paper presents the work done on the levitated spherical actuator and more precisely the electrical drive including its control unit and power parts. An elegant breadboard is currently being manufactured within the frame of an FP7 project. This project also comprises a feasibility study to show the feasibility of integrating such a system on a flight platform and to identify all the challenges to be solved in terms of technology or components to be developed.

  14. Methoden voor Voorraadbeheersing van Repareerbare Reservedelen: METRIC en Enkele Varianten (Methodes for Repairable Item Inventory Control: METRIC and Some Variants)

    DTIC Science & Technology

    1990-08-01

    geval van repareerbare items (voor niet-repareerbare items altijd 0), backorders - aantal exemplaren/ stuks van een item dat niet direct geleverd kan...worden (bet aantal stuks in nalevering). Hierbij geldt automatisch dat van de termen "on hand" en "backorders" minstens een van beide gelijk san nul is

  15. Aqueous gating of van der Waals materials on bilayer nanopaper.

    PubMed

    Bao, Wenzhong; Fang, Zhiqiang; Wan, Jiayu; Dai, Jiaqi; Zhu, Hongli; Han, Xiaogang; Yang, Xiaofeng; Preston, Colin; Hu, Liangbing

    2014-10-28

    In this work, we report transistors made of van der Waals materials on a mesoporous paper with a smooth nanoscale surface. The aqueous transistor has a novel planar structure with source, drain, and gate electrodes on the same surface of the paper, while the mesoporous paper is used as an electrolyte reservoir. These transistors are enabled by an all-cellulose paper with nanofibrillated cellulose (NFC) on the top surface that leads to an excellent surface smoothness, while the rest of the microsized cellulose fibers can absorb electrolyte effectively. Based on two-dimensional van der Waals materials, including MoS2 and graphene, we demonstrate high-performance transistors with a large on-off ratio and low subthreshold swing. Such planar transistors with absorbed electrolyte gating can be used as sensors integrated with other components to form paper microfluidic systems. This study is significant for future paper-based electronics and biosensors.

  16. Discrete structure of van der Waals domains in globular proteins.

    PubMed

    Berezovsky, Igor N

    2003-03-01

    Most globular proteins are divisible by domains, distinct substructures of the globule. The notion of hierarchy of the domains was introduced earlier via van der Waals energy profiles that allow one to subdivide the proteins into domains (subdomains). The question remains open as to what is the possible structural connection of the energy profiles. The recent discovery of the loop-n-lock elements in the globular proteins suggests such a structural connection. A direct comparison of the segmentation by van der Waals energy criteria with the maps of the locked loops of nearly standard size reveals a striking correlation: domains in general appear to consist of one to several such loops. In addition, it was demonstrated that a variety of subdivisions of the same protein into domains is just a regrouping of the loop-n-lock elements.

  17. Accurate van der Waals coefficients from density functional theory

    PubMed Central

    Tao, Jianmin; Perdew, John P.; Ruzsinszky, Adrienn

    2012-01-01

    The van der Waals interaction is a weak, long-range correlation, arising from quantum electronic charge fluctuations. This interaction affects many properties of materials. A simple and yet accurate estimate of this effect will facilitate computer simulation of complex molecular materials and drug design. Here we develop a fast approach for accurate evaluation of dynamic multipole polarizabilities and van der Waals (vdW) coefficients of all orders from the electron density and static multipole polarizabilities of each atom or other spherical object, without empirical fitting. Our dynamic polarizabilities (dipole, quadrupole, octupole, etc.) are exact in the zero- and high-frequency limits, and exact at all frequencies for a metallic sphere of uniform density. Our theory predicts dynamic multipole polarizabilities in excellent agreement with more expensive many-body methods, and yields therefrom vdW coefficients C6, C8, C10 for atom pairs with a mean absolute relative error of only 3%. PMID:22205765

  18. Van der Waals density functional: An appropriate exchange functional

    NASA Astrophysics Data System (ADS)

    Cooper, Valentino R.

    2010-04-01

    In this Rapid Communication, an exchange functional which is compatible with the nonlocal Rutgers-Chalmers correlation functional [van der Waals density functional (vdW-DF)] is presented. This functional, when employed with vdW-DF, demonstrates remarkable improvements on intermolecular separation distances while further improving the accuracy of vdW-DF interaction energies. The key to the success of this three-parameter functional is its reduction in short-range exchange repulsion through matching to the gradient expansion approximation in the slowly varying/high-density limit while recovering the large reduced gradient, s , limit set in the revised Perdew-Burke-Ernzerhof (revPBE) exchange functional. This augmented exchange functional could be a solution to long-standing issues of vdW-DF lending to further applicability of density-functional theory to the study of relatively large, dispersion bound (van der Waals) complexes.

  19. IVAN: Intelligent Van for the Distribution of Pharmaceutical Drugs

    PubMed Central

    Moreno, Asier; Angulo, Ignacio; Perallos, Asier; Landaluce, Hugo; Zuazola, Ignacio Julio García; Azpilicueta, Leire; Astrain, José Javier; Falcone, Francisco; Villadangos, Jesús

    2012-01-01

    This paper describes a telematic system based on an intelligent van which is capable of tracing pharmaceutical drugs over delivery routes from a warehouse to pharmacies, without altering carriers' daily conventional tasks. The intelligent van understands its environment, taking into account its location, the assets and the predefined delivery route; with the capability of reporting incidences to carriers in case of failure according to the established distribution plan. It is a non-intrusive solution which represents a successful experience of using smart environments and an optimized Radio Frequency Identification (RFID) embedded system in a viable way to resolve a real industrial need in the pharmaceutical industry. The combination of deterministic modeling of the indoor vehicle, the implementation of an ad-hoc radiating element and an agile software platform within an overall system architecture leads to a competitive, flexible and scalable solution. PMID:22778659

  20. Towards a more accurate van der Waals density functional

    NASA Astrophysics Data System (ADS)

    Hamada, Ikutaro

    2014-03-01

    The van der Waals density functional (vdW-DF) of Dion et al. [1] has attracted considerable attention, because the functional is able to describe intra- and intermolecular bondings with different natures, e.g., covalent and van der Waals bondings in a seamless fashion within the framework of density functional theory. However, the accuracy of the functional is yet to be improved for the applications to various systems. Here I propose an exchange functional for the second version of vdW-DF [2], which improves the accuracy of vdW-DF. The keys in the improved exchange are the matching to the gradient expansion approximation in the slowly varying limit and the large density gradient behavior set in Becke's exchange (B86b)[3]. Systematic study on gas phase molecules, solids, and molecular adsorption demonstrates the applicability of the proposed functional to a wide variety of materials.

  1. IVAN: intelligent van for the distribution of pharmaceutical drugs.

    PubMed

    Moreno, Asier; Angulo, Ignacio; Perallos, Asier; Landaluce, Hugo; García Zuazola, Ignacio Julio; Azpilicueta, Leire; Astrain, José Javier; Falcone, Francisco; Villadangos, Jesús

    2012-01-01

    This paper describes a telematic system based on an intelligent van which is capable of tracing pharmaceutical drugs over delivery routes from a warehouse to pharmacies, without altering carriers' daily conventional tasks. The intelligent van understands its environment, taking into account its location, the assets and the predefined delivery route; with the capability of reporting incidences to carriers in case of failure according to the established distribution plan. It is a non-intrusive solution which represents a successful experience of using smart environments and an optimized Radio Frequency Identification (RFID) embedded system in a viable way to resolve a real industrial need in the pharmaceutical industry. The combination of deterministic modeling of the indoor vehicle, the implementation of an ad-hoc radiating element and an agile software platform within an overall system architecture leads to a competitive, flexible and scalable solution.

  2. Poisson-Boltzmann Calculations: van der Waals or Molecular Surface?

    PubMed Central

    Pang, Xiaodong; Zhou, Huan-Xiang

    2012-01-01

    The Poisson-Boltzmann equation is widely used for modeling the electrostatics of biomolecules, but the calculation results are sensitive to the choice of the boundary between the low solute dielectric and the high solvent dielectric. The default choice for the dielectric boundary has been the molecular surface, but the use of the van der Waals surface has also been advocated. Here we review recent studies in which the two choices are tested against experimental results and explicit-solvent calculations. The assignment of the solvent high dielectric constant to interstitial voids in the solute is often used as a criticism against the van der Waals surface. However, this assignment may not be as unrealistic as previously thought, since hydrogen exchange and other NMR experiments have firmly established that all interior parts of proteins are transiently accessible to the solvent. PMID:23293674

  3. Poisson-Boltzmann Calculations: van der Waals or Molecular Surface?

    PubMed

    Pang, Xiaodong; Zhou, Huan-Xiang

    2013-01-01

    The Poisson-Boltzmann equation is widely used for modeling the electrostatics of biomolecules, but the calculation results are sensitive to the choice of the boundary between the low solute dielectric and the high solvent dielectric. The default choice for the dielectric boundary has been the molecular surface, but the use of the van der Waals surface has also been advocated. Here we review recent studies in which the two choices are tested against experimental results and explicit-solvent calculations. The assignment of the solvent high dielectric constant to interstitial voids in the solute is often used as a criticism against the van der Waals surface. However, this assignment may not be as unrealistic as previously thought, since hydrogen exchange and other NMR experiments have firmly established that all interior parts of proteins are transiently accessible to the solvent.

  4. [Neuropsychiatry and creativity: "Starry night" of Van Gogh].

    PubMed

    Abundes-Corona, Rodolfo Arturo; Corona Vázquez, Teresa

    2014-01-01

    The life of Vincent van Gogh (1853-1890) has been studied thoroughly by humanists and scientists alike. His biography is an archetype of the relationship between creativity and disease. In 1956, Henri Gastaut defined his diagnosis as temporal lobe epilepsy. The artist was known for an eccentric personality and unpredictable mood, with recurrent psychotic bouts through the last two years of his life. Several authors have considered the possibility that van Gogh also suffered from bipolar affective disorder. We conducted a biographical and epistolary review with the objective of analyzing the complexity of his disease and the effects it had on his art, which ultimately placed him as one of the greatest geniuses in art.

  5. Computerized Comparison and Analysis of Vincent van Gogh's Painting Brushstrokes

    NASA Astrophysics Data System (ADS)

    Wang, James Z.

    2009-03-01

    With advanced digitization techniques, museums have routinely begun to assemble vast digital libraries of images of their collections. These images can be analyzed by computers to assist art historians for a number of tasks. In our work, we focus on three challenges: artist identification, dating of an art work, and finding distinguishing features among artists. Two complementary approaches were taken: (1) the analysis of the geometric statistics based on the extracted individual brushstroke, and (2) the modeling of overall brushstroke texture. These approaches aim at assisting art historians in comparing a painting or parts of a painting to a group of paintings based on multiple criteria. Statistical methods have been used to compare groups of paintings. Each painting image is divided into subimages. Individual brushstrokes are segmented automatically. Geometric features, including the curvature, the overall orientation, and the size, are computed for each brushstroke. We also compute the features representing the interactivity of the brushstrokes extracted. The statistics, including average and standard deviation, of those features are used to model certain aspects of the artist's brushstrokes. For capturing the local brushstroke texture, we first apply a wavelet transform to the image. A spatial model, the 2-D hidden Markov model, is used to model the texture features of each subimage. The methods have shown to be able to distinguish van Gogh paintings and non van Gogh paintings to a great extent. The techniques can provide clues for the dating of van Gogh paintings. A comparison of the van Gogh paintings, Monticelli's paintings, and paintings by contemporary artists provides insights on their similarities and differences. The analysis has provided numerical statistics for further studying these and other paintings.

  6. STS-121 crewmembers prepare to board transfer van at KSC

    NASA Image and Video Library

    2006-07-04

    STS121-S-006 (4 July 2006) --- The STS-121 crewmembers, having donned their shuttle launch and entry suits, wave flags for the Fourth of July as they prepare to board the transfer van awaiting to take them to Launch Pad 39B. Steven W. Lindsey (right front), commander, and Mark E. Kelly, pilot, lead the way. Other crewmembers - Lisa M. Nowak, Michael E. Fossum, Stephanie D. Wilson, Piers J. Sellers and European Space Agency (ESA) astronaut Thomas Reiter of Germany - follow.

  7. Structure and dynamics of small van der Waals complexes

    SciTech Connect

    Loreau, J.

    2014-10-06

    We illustrate computational aspects of the calculation of the potential energy surfaces of small (up to five atoms) van der Waals complexes with high-level quantum chemistry techniques such as the CCSD(T) method with extended basis sets. We discuss the compromise between the required accuracy and the computational time. Further, we show how these potential energy surfaces can be fitted and used in dynamical calculations such as non-reactive inelastic scattering.

  8. The van Cittert-Zernike theorem for electromagnetic fields.

    PubMed

    Ostrovsky, Andrey S; Martínez-Niconoff, Gabriel; Martínez-Vara, Patricia; Olvera-Santamaría, Miguel A

    2009-02-02

    The van Cittert-Zernike theorem, well known for the scalar optical fields, is generalized for the case of vector electromagnetic fields. The deduced theorem shows that the degree of coherence of the electromagnetic field produced by the completely incoherent vector source increases on propagation whereas the degree of polarization remains unchanged. The possible application of the deduced theorem is illustrated by an example of optical simulation of partially coherent and partially polarized secondary source with the controlled statistical properties.

  9. [Case report Brown-Vialetto-Van laere syndrome].

    PubMed

    Introini, S; Sasso, G M; Moioli, G; Morandini, W L

    2003-01-01

    A case of a young man (36 years old) suffering from a progressive bulbo-pontine palsy, bilateral central deafness and respiratory failure, clinically known as Brown-Vialetto-Van Laere syndrome (BVVL) is reported. The illness occurred at 24 years and, after a period of quiescence of 12 years, led to a serious dependence from mechanical ventilation. In tyhis report the most important points of view about resuscitation and intensive treatment, such as neuromuscular failure and locked-in condition, are discussed.

  10. QUEST: Quality of Expert Systems (QUEST: Kwaliteit van Expertsystemen)

    DTIC Science & Technology

    1990-11-01

    conceptuele overeenkomsten tussen gegevensbanken en kennisbanken. Ixnplicatie hiervan is het gebruik van Nijssens Infonnatie-Analyse Methode (NIAM) als...UNCLASSIFIED) 2 SAMENVATTING (ONGERUBRICEERD) 3 CONTENTS 4 INTRODUCTION 6 2 A QUALITY FRAMEWORK 12 2.1 Introduction 12 2.2 Problem analysis 12 2.3 A... management systems (RDBMSs) have benefited from this principle. In this study, therefore, expert system development will primarily be viewed as

  11. Grippers Based on Opposing Van Der Waals Adhesive Pads

    NASA Technical Reports Server (NTRS)

    Parness, Aaron (Inventor); Kennedy, Brett A. (Inventor); Heverly, Matthew C (Inventor); Cutkosky, Mark R. (Inventor); Hawkes, Elliot Wright (Inventor)

    2016-01-01

    Novel gripping structures based on van der Waals adhesive forces are disclosed. Pads covered with fibers can be activated in pairs by opposite forces, thereby enabling control of the adhesive force in an ON or OFF state. Pads can be used in groups, each comprising a group of opposite pads. The adhesive structures enable anchoring forces that can resist adverse forces from different directions. The adhesive structures can be used to enable the operation of robots on surfaces of space vehicles.

  12. A reappraisal of the possible seizures of Vincent van Gogh.

    PubMed

    Hughes, John R

    2005-06-01

    The tragic life of Vincent van Gogh is summarized, emphasizing his early departure from formal education, failure as a successful salesman in the art world, attempt at religious studies, difficulty with female and family relationships, return to the art world, and tendencies toward extremes of poor nutrition or near self-starvation and excessive drinking and smoking. In Paris he joined the Impressionists, but drank very heavily both absinthe and cognac. Southward he went to Arles and was joined by Paul Gauguin, with whom he had major personality problems, causing van Gogh to cut off part of his left ear. He experienced paranoid ideation and confinement in mental institutions in Arles, and then returned to Paris and onto Auvers-sur-Oise, where he committed suicide at age 37. Possible physical diagnoses include glaucoma, Meniere's disease, acute intermittent porphyria, and chronic lead poisoning, but these diagnoses seem unlikely. Possible psychiatric diagnoses include borderline personality disorder, anxiety-depressive disorder with episodes of depression and hypomania, and also paranoid schizophrenia. Van Gogh did not have spontaneous seizures and, therefore, did not have epilepsy. Before he began to drink heavily, when he was near starvation, he had "fainting fits," and after drinking, especially absinthe, a convulsant drug, he continued to have similar attacks. His episodes of unconsciousness can be well explained by chronic malnutrition and alcohol abuse, only possibly exacerbated by drinking large quantities of absinthe. Although van Gogh is an excellent example of the Geschwind syndrome, at times associated with temporal lobe epilepsy, this fact does not establish such an epilepsy. Thus, the syndrome is an orphan without the parent condition.

  13. Dynamic changes of phase in a van der Waals fluid

    NASA Astrophysics Data System (ADS)

    Hagan, R.; Serrin, J.

    1984-03-01

    This paper gives sufficient conditions to guarantee the existence of a shock layer solution connecting two different equilibrium states in a van der Waals fluid. In particular, the equilibrium states can belong to two different phases of the fluid. The constitutive laws come from a modified Korteweg theory which is compatible with the Clausius Duhem inequality. The Clausius Duhem inequality in turn gives rise to a Liapunov function. The main mathematical tool is the LaSalle invariance principle.

  14. The wing of madness: the illness of Vincent van Gogh.

    PubMed

    Morrant, J C

    1993-09-01

    This paper briefly describes some aspects of Vincent van Gogh's life and attitudes. It discusses absinthe and several psychodynamic factors that may have contributed to his psychotic episodes at Arles, when he cut off his ear. It discusses Vincent's descriptions of his illness, especially at Saint Rémy de Provence and concludes that he probably suffered from partial complex seizures (temporal lobe epilepsy) with manic depressive mood swings aggravated by absinthe, brandy, nicotine and turpentine.

  15. Verification Test of Jet Industries Electra-Van 1000P,

    DTIC Science & Technology

    1980-10-01

    Assistant Secretary for Conservation and Solar Ene ion of Electric Unclassified and Hybrid Vehicles 15 I Ia. DEL S FCATIOt OWNGRADING 16. DISTRIBUTION...different bce Report) IS. SUPPLEMENTARY NOTES 19. KEY WORDS (Confinue on reverse side If necesiay and Identify by block nemiber) Electric Vehicle ...truck which has been con- verted to an electric vehicle . It was tested b A as part of a Department of Energy demonstration program. The Electra-Van

  16. Nano Electronics on Atomically Controlled van der Waals Quantum Heterostructures

    DTIC Science & Technology

    2015-03-30

    ES) Columbia University 538 West 120th Street New York 10027 United States 8. PERFORMING ORGANIZATION REPORT NUMBER N/A 9...dimensional (2D) van der Waals (vdW) materials for the realization of novel quantum electronic states . We employed molecular beam epitaxy (MBE) combined with...transitions between retro intraband and specular interband Andreev reflections opens a new route for future experiments that could employ the gate

  17. Van Allen Probes Science Gateway and Space Weather Data Processing

    NASA Astrophysics Data System (ADS)

    Romeo, G.; Barnes, R. J.; Weiss, M.; Fox, N. J.; Mauk, B.; Potter, M.; Kessel, R.

    2014-12-01

    The Van Allen Probes Science Gateway acts as a centralized interface to the instrument Science Operation Centers (SOCs), provides mission planning tools, and hosts a number of science related activities such as the mission bibliography. Most importantly, the Gateway acts as the primary site for processing and delivering the VAP Space Weather data to users. Over the past year, the web-site has been completely redesigned with the focus on easier navigation and improvements of the existing tools such as the orbit plotter, position calculator and magnetic footprint tool. In addition, a new data plotting facility has been added. Based on HTML5, which allows users to interactively plot Van Allen Probes summary and space weather data. The user can tailor the tool to display exactly the plot they wish to see and then share this with other users via either a URL or by QR code. Various types of plots can be created, including simple time series, data plotted as a function of orbital location, and time versus L-Shell. We discuss the new Van Allen Probes Science Gateway and the Space Weather Data Pipeline.

  18. Scaling Laws for van der Waals Interactions in Nanostructured Materials

    NASA Astrophysics Data System (ADS)

    Gobre, Vivekanand; Tkatchenko, Alexandre

    2014-03-01

    Van der Waals (vdW) forces originate from interactions between fluctuating multipoles in matter and play a significant role in the structure and stability of nanostructured materials. Many models used to describe vdW interactions in nanomaterials are based on a simple pairwise-additive approximation, neglecting the strong electrodynamic response effects caused by long-range fluctuations in matter. We develop and utilize an efficient microscopic method to demonstrate that vdW interactions in nanomaterials act at distances greater than typically assumed, and can be characterized by different scaling laws depending on the dimensionality and size of the system. Specifically, we study the behaviour of vdW interactions in single-layer and multilayer graphene, fullerenes of varying size, single-wall carbon nanotubes and graphene nanoribbons. As a function of nanostructure size, the van der Waals coefficients follow unusual trends for all of the considered systems, and deviate significantly from the conventionally employed pairwise-additive picture. We propose that the peculiar van der Waals interactions in nanostructured materials could be exploited to control their self-assembly.

  19. Mid infrared observations of Van Maanen 2: no substellar companion.

    SciTech Connect

    Farihi, J; Becklin, E; Macintosh, B

    2004-11-03

    The results of a comprehensive infrared imaging search for the putative 0.06 M{sub {circle_dot}} astrometric companion to the 4.4 pc white dwarf van Mannen 2 are reported. Adaptive optics images acquired at 3.8 {micro}m reveal a diffraction limited core of 0.09 inch and no direct evidence of a secondary. Models predict that at 5 Gyr, a 50 M{sub J} brown dwarf would be only 1 magnitude fainter than van Maanen 2 at this wavelength and the astrometric analysis suggested a separation of 0.2 inch. In the case of a chance alignment along the line of sight, a 0.4 mag excess should be measured. An independent photometric observation at the same wavelength reveals no excess. In addition, there exist published ISO observations of van Maanen 2 at 6.8 {micro}m and 15.0 {micro}m which are consistent with photospheric flux of a 6750 K white dwarf. If recent brown dwarf models are correct, there is no substellar companion with T{sub eff} {approx}> 500 K.

  20. Observation of van Hove Singularities in Twisted Silicene Multilayers

    PubMed Central

    2016-01-01

    Interlayer interactions perturb the electronic structure of two-dimensional materials and lead to new physical phenomena, such as van Hove singularities and Hofstadter’s butterfly pattern. Silicene, the recently discovered two-dimensional form of silicon, is quite unique, in that silicon atoms adopt competing sp2 and sp3 hybridization states leading to a low-buckled structure promising relatively strong interlayer interaction. In multilayer silicene, the stacking order provides an important yet rarely explored degree of freedom for tuning its electronic structures through manipulating interlayer coupling. Here, we report the emergence of van Hove singularities in the multilayer silicene created by an interlayer rotation. We demonstrate that even a large-angle rotation (>20°) between stacked silicene layers can generate a Moiré pattern and van Hove singularities due to the strong interlayer coupling in multilayer silicene. Our study suggests an intriguing method for expanding the tunability of the electronic structure for electronic applications in this two-dimensional material. PMID:27610412

  1. Recent Science Highlights of the Van Allen Probes Mission

    NASA Astrophysics Data System (ADS)

    Ukhorskiy, Aleksandr

    2016-10-01

    The morning of 30 August 2012 saw an Atlas 5 rocket launch NASA's second Living With a Star spacecraft mission, the twin Radiation Belt Storm Probes, into an elliptic orbit cutting through Earth's radiation belts. Renamed the Van Allen Probes soon after launch, the Probes are designed to determine how the highly variable populations of high-energy charged particles within the radiation belts, dangerous to astronauts and satellites, are created, respond to solar variations, and evolve in space environments. The Van Allen Probes mission extends beyond the practical considerations of the hazard's of Earth's space environment. Twentieth century observations of space and astrophysical systems throughout the solar system and out into the observable universe have shown that the processes that generate intense particle radiation within magnetized environments such as Earth's are universal. During its mission the Van Allen Probes verified and quantified previously suggested energization processes, discovered new energization mechanisms, revealed the critical importance of dynamic plasma injections into the innermost magnetosphere, and used uniquely capable instruments to reveal inner radiation belt features that were all but invisible to previous sensors. This paper gives a brief overview of the mission, presents some recent science highlights, and discusses plans for the extended mission.

  2. Comment to the Article by van Arensbergen and van den Besselaar "The Selection of Scientific Talent in the Allocation of Research Grants"

    ERIC Educational Resources Information Center

    Maessen, K. M. H.

    2012-01-01

    The article entitled "The selection of scientific talent in the allocation of research grants" by van Arensbergen and van den Besselaar published in "Higher Education Policy" 25/3 (2012) is based on research that both researchers carried out on behalf of The Netherlands Organisation for Scientific Research. In this comment, we…

  3. The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance.

    PubMed

    Ammam, Fariza; Meziane-Cherif, Djalal; Mengin-Lecreulx, Dominique; Blanot, Didier; Patin, Delphine; Boneca, Ivo G; Courvalin, Patrice; Lambert, Thierry; Candela, Thomas

    2013-08-01

    vanGCd, a cryptic gene cluster highly homologous to the vanG gene cluster of Enterococcus faecalis is largely spread in Clostridium difficile. Since emergence of vancomycin resistance would have dramatic clinical consequences, we have evaluated the capacity of the vanGCd cluster to confer resistance. We showed that expression of vanGCd is inducible by vancomycin and that VanGCd , VanXYCd and VanTCd are functional, exhibiting D-Ala : D-Ser ligase, D,D-dipeptidase and D-Ser racemase activities respectively. In other bacteria, these enzymes are sufficient to promote vancomycin resistance. Trans-complementation of C. difficile with the vanC resistance operon of Enterococcus gallinarum faintly impacted the MIC of vancomycin, but did not promote vancomycin resistance in C. difficile. Sublethal concentration of vancomycin led to production of UDP-MurNAc-pentapeptide[D-Ser], suggesting that the vanGCd gene cluster is able to modify the peptidoglycan precursors. Our results indicated amidation of UDP-MurNAc-tetrapeptide, UDP-MurNAc-pentapeptide[D-Ala] and UDP-MurNAc-pentapeptide[D-Ser]. This modification is passed on the mature peptidoglycan where a muropeptide Tetra-Tetra is amidated on the meso-diaminopimelic acid. Taken together, our results suggest that the vanGCd gene cluster is functional and is prevented from promoting vancomycin resistance in C. difficile. © 2013 John Wiley & Sons Ltd.

  4. Chlorhexidine Induces VanA-Type Vancomycin Resistance Genes in Enterococci

    PubMed Central

    Bhardwaj, Pooja; Ziegler, Elizabeth

    2016-01-01

    Chlorhexidine is a bisbiguanide antiseptic used for infection control. Vancomycin-resistant E. faecium (VREfm) is among the leading causes of hospital-acquired infections. VREfm may be exposed to chlorhexidine at supra- and subinhibitory concentrations as a result of chlorhexidine bathing and chlorhexidine-impregnated central venous catheter use. We used RNA sequencing to investigate how VREfm responds to chlorhexidine gluconate exposure. Among the 35 genes upregulated ≥10-fold after 15 min of exposure to the MIC of chlorhexidine gluconate were those encoding VanA-type vancomycin resistance (vanHAX) and those associated with reduced daptomycin susceptibility (liaXYZ). We confirmed that vanA upregulation was not strain or species specific by querying other VanA-type VRE. VanB-type genes were not induced. The vanH promoter was found to be responsive to subinhibitory chlorhexidine gluconate in VREfm, as was production of the VanX protein. Using vanH reporter experiments with Bacillus subtilis and deletion analysis in VREfm, we found that this phenomenon is VanR dependent. Deletion of vanR did not result in increased chlorhexidine susceptibility, demonstrating that vanHAX induction is not protective against chlorhexidine. As expected, VanA-type VRE is more susceptible to ceftriaxone in the presence of sub-MIC chlorhexidine. Unexpectedly, VREfm is also more susceptible to vancomycin in the presence of subinhibitory chlorhexidine, suggesting that chlorhexidine-induced gene expression changes lead to additional alterations in cell wall synthesis. We conclude that chlorhexidine induces expression of VanA-type vancomycin resistance genes and genes associated with daptomycin nonsusceptibility. Overall, our results indicate that the impacts of subinhibitory chlorhexidine exposure on hospital-associated pathogens should be further investigated in laboratory studies. PMID:26810654

  5. Substrate Inhibition of VanA by d-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner

    PubMed Central

    van der Aart, Lizah T.; Lemmens, Nicole; van Wamel, Willem J.

    2016-01-01

    The increasing resistance of clinical pathogens against the glycopeptide antibiotic vancomycin, a last-resort drug against infections with Gram-positive pathogens, is a major problem in the nosocomial environment. Vancomycin inhibits peptidoglycan synthesis by binding to the d-Ala–d-Ala terminal dipeptide moiety of the cell wall precursor lipid II. Plasmid-transferable resistance is conferred by modification of the terminal dipeptide into the vancomycin-insensitive variant d-Ala–d-Lac, which is produced by VanA. Here we show that exogenous d-Ala competes with d-Lac as a substrate for VanA, increasing the ratio of wild-type to mutant dipeptide, an effect that was augmented by several orders of magnitude in the absence of the d-Ala–d-Ala peptidase VanX. Liquid chromatography-mass spectrometry (LC-MS) analysis showed that high concentrations of d-Ala led to the production of a significant amount of wild-type cell wall precursors, while vanX-null mutants produced primarily wild-type precursors. This enhanced the efficacy of vancomycin in the vancomycin-resistant model organism Streptomyces coelicolor, and the susceptibility of vancomycin-resistant clinical isolates of Enterococcus faecium (VRE) increased by up to 100-fold. The enhanced vancomycin sensitivity of S. coelicolor cells correlated directly to increased binding of the antibiotic to the cell wall. Our work offers new perspectives for the treatment of diseases associated with vancomycin-resistant pathogens and for the development of drugs that target vancomycin resistance. PMID:27270282

  6. Eindrapportage van het Onderzoek naar de Meerwaarde van BMS (Final Report of the Investigation into the Value of BMS)

    DTIC Science & Technology

    2005-11-01

    Onderzoek TWAG Terrein Winnen en Achterwaarts Gaan VM Vijandelijke mogelijkheid TNO-rapport I TNO-DV1 2005 A100 6/42 Inleiding Dit rapport geeft een...te gaan op de achterliggende redenen van de antwoorden. De interviews zijn bedoeld om bet beeld dat uit de observaties en de vragenlijsten is ontstaan...verspreide Iormatie Tcrrein Winnen en Achterwaarts Gaan (TWAG) / ecn bereden aanval; " een veiligheidsbezetting; * een hoszuivering. Voor cen succesvolle

  7. From vanA Enterococcus hirae to vanA Enterococcus faecium: a Study of Feed Supplementation with Avoparcin and Tylosin in Young Chickens

    PubMed Central

    Robredo, Beatriz; Singh, Kavindra V.; Baquero, Fernando; Murray, Barbara E.; Torres, Carmen

    1999-01-01

    Fifteen newborn chickens were isolated in separate cages after 1 month of living together, divided into three groups, and challenged for 5 weeks with seed food which either was supplemented with avoparcin (10 mg/kg of animal food) or tylosin (40 mg/kg) or was nonsupplemented. At 9 weeks of age and after the 5-week challenge, all chickens received nonsupplemented feed for 4 additional weeks. At 4, 9, and 13 weeks of life, feces were collected and inoculated on M-Enterococcus agar plates with and without vancomycin (4 μg/ml). vanA-containing Enterococcus hirae was isolated from 11 of 15 chickens before antibiotic challenge, without detection of vancomycin-resistant Enterococcus faecium. At 9 weeks of age and after the 5-week avoparcin challenge, vanA E. hirae strains were no longer detected, but five of five chickens now had vanA E. faecium. At a lower frequency, vanA E. faecium had also displaced vanA E. hirae in both the tylosin group (one of four chickens) and the control group (two of five chickens). One month after avoparcin discontinuation, the number of chickens colonized with vanA E. faecium decreased from five to one. All vanA-containing E. hirae strains detected in the first month of life and most of the vanA-containing E. faecium strains detected in the second month of life showed identical ApaI and SmaI restriction patterns, respectively, when analyzed by pulsed-field gel electrophoresis. All vanA E. hirae isolates transferred glycopeptide and macrolide resistance to Enterococcus faecalis JH2-2 in vitro; the level of glycopeptide resistance was higher in the transconjugants than in the donor E. hirae strains. These data suggest that E. hirae may be a significant source of vanA determinants with the potential of transfer to other enterococcal species from humans or animals. PMID:10223926

  8. Rhythmic brushstrokes distinguish van Gogh from his contemporaries: findings via automated brushstroke extraction.

    PubMed

    Li, Jia; Yao, Lei; Hendriks, Ella; Wang, James Z

    2012-06-01

    Art historians have long observed the highly characteristic brushstroke styles of Vincent van Gogh and have relied on discerning these styles for authenticating and dating his works. In our work, we compared van Gogh with his contemporaries by statistically analyzing a massive set of automatically extracted brushstrokes. A novel extraction method is developed by exploiting an integration of edge detection and clustering-based segmentation. Evidence substantiates that van Gogh's brushstrokes are strongly rhythmic. That is, regularly shaped brushstrokes are tightly arranged, creating a repetitive and patterned impression. We also found that the traits that distinguish van Gogh's paintings in different time periods of his development are all different from those distinguishing van Gogh from his peers. This study confirms that the combined brushwork features identified as special to van Gogh are consistently held throughout his French periods of production (1886-1890).

  9. Application of diffusion Monte Carlo to materials dominated by van der Waals interactions

    SciTech Connect

    Benali, Anouar; Shulenburger, Luke; Romero, Nichols; Kim, Jeongnim; Von Lilienfeld, Anatole

    2014-01-01

    Van der Waals forces are notoriously difficult to account for from first principles. We perform extensive calculation to assess the usefulness and validity of diffusion quantum Monte Carlo when applied to van der Waals forces. We present results for noble gas solids and clusters - archetypical van der Waals dominated assemblies, as well as a relevant pi-pi stacking supramolecular complex: DNA + intercalating anti-cancer drug Ellipticine.

  10. Application of Diffusion Monte Carlo to Materials Dominated by van der Waals Interactions

    DOE PAGES

    Benali, Anouar; Shulenburger, Luke; Romero, Nichols A.; ...

    2014-06-12

    Van der Waals forces are notoriously difficult to account for from first principles. We perform extensive calculation to assess the usefulness and validity of diffusion quantum Monte Carlo when applied to van der Waals forces. We present results for noble gas solids and clusters - archetypical van der Waals dominated assemblies, as well as a relevant pi-pi stacking supramolecular complex: DNA + intercalating anti-cancer drug Ellipticine.

  11. [Jean-Baptiste Van Helmont (1579-1644), the baroque and teeth].

    PubMed

    Gysel, C

    1979-01-01

    J. B. Van Helmont has been qualified as a medical exponent of the baroque spirit. This affirmation can only be accepted in the following sense: as Harvey, but in an other way. Van Helmont has prepared modern medicine notwithstanding their fidelity to the philosophy of nature (aristotelism or irrationalism) of the sixteenth century. Van Helmont, who believed in the occult forces of the teeth, was also the first to denounce the catarrhe as a cause of toothache.

  12. Quality of Expert Systems: Methods and Techniques (Kwaliteit van Expertsystemen: Methoden en Technieken)

    DTIC Science & Technology

    1989-12-01

    volledigheid van specificaties. De volledigheid is gewaarborgd door bet 100% principe. Het gebruik van een fornele taal voor vastlegging van de...impliceert statement coverage. c ) Condition coverage: ledere ’conditie’ (term in een Iogische expressie) moet bij bet testen tenminste een keer TRUE en...bijvoorbeeld een waarbij c I TRUE en c2 FALSE oplevert en een waarbij bet omgekeerde bet geval is. Merk op dat in dit geval niet aan decision coverage

  13. Interim Project Results: United Parcel Service's Second-Generation Hybrid-Electric Delivery Vans (Fact Sheet)

    SciTech Connect

    Not Available

    2012-01-01

    This fact sheet describes the performance evaluation of United Parcel Service's second-generation hybrid-electric delivery vans. The Fleet Test and Evaluation Team at the National Renewable Energy Laboratory (NREL) is evaluating the 18-month, in-service performance of 11 of these vans along with 11 comparable conventional diesel vans operating in Minneapolis, Minnesota. As a complement to the field study, the team recently completed fuel economy and emissions testing at NREL's Renewable Fuels and Lubricants (ReFUEL) laboratory.

  14. Project Overview: United Parcel Service's Second-Generation Hybrid-Electric Delivery Vans (Fact Sheet)

    SciTech Connect

    Not Available

    2011-11-01

    This fact sheet describes UPS second generation hybrid-electric delivery vehicles as compared to conventional delivery vehicles. Medium-duty commercial vehicles such as moving trucks, beverage-delivery trucks, and package-delivery vans consume almost 2,000 gal of fuel per year on average. United Parcel Service (UPS) operates hybrid-electric package-delivery vans to reduce the fuel use and emissions of its fleet. In 2008, the National Renewable Energy Laboratory's (NREL's) Fleet Test and Evaluation Team evaluated the first generation of UPS' hybrid delivery vans. These hybrid vans demonstrated 29%-37% higher fuel economy than comparable conventional diesel vans, which contributed to UPS' decision to add second-generation hybrid vans to its fleet. The Fleet Test and Evaluation Team is now evaluating the 18-month, in-service performance of 11 second-generation hybrid vans and 11 comparable conventional diesel vans operated by UPS in Minneapolis, Minnesota. The evaluation also includes testing fuel economy and emissions at NREL's Renewable Fuels and Lubricants (ReFUEL) Laboratory and comparing diesel particulate filter (DPF) regeneration. In addition, a followup evaluation of UPS' first-generation hybrid vans will show how those vehicles performed over three years of operation. One goal of this project is to provide a consistent comparison of fuel economy and operating costs between the second-generation hybrid vans and comparable conventional vans. Additional goals include quantifying the effects of hybridization on DPF regeneration and helping UPS select delivery routes for its hybrid vans that maximize the benefits of hybrid technology. This document introduces the UPS second-generation hybrid evaluation project. Final results will be available in mid-2012.

  15. Jacobus Schroeder van der Kolk (1797-1862): his resistance against materialism.

    PubMed

    Eling, P

    1998-07-01

    Schroeder van der Kolk is regarded as the founder of Dutch psychiatry and neurology. This paper describes his vitalistic views on the relation between body and soul, as formulated by him in a series of lectures. These lectures were intended to counteract the materialistic tendencies of some of Schroeder van der Kolk's French and German contemporaries. It is argued that Schroeder van der Kolk can be regarded as the transition in Holland from the "Naturphilosophie" approach to the modern experimental approach in physiology.

  16. 46 CFR 195.11-10 - Design and construction of portable vans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... outfitted with electrical power generating machinery or batteries providing electrical power for other vans... requirements of this subchapter for pressure piping, electrical, fire extinguishing and ventilation systems....

  17. 46 CFR 195.11-10 - Design and construction of portable vans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... outfitted with electrical power generating machinery or batteries providing electrical power for other vans... requirements of this subchapter for pressure piping, electrical, fire extinguishing and ventilation systems....

  18. VanE-type vancomycin-resistant Enterococcus faecalis clinical isolates from Australia.

    PubMed

    Abadía-Patiño, Lorena; Christiansen, Keryn; Bell, Jan; Courvalin, Patrice; Périchon, Bruno

    2004-12-01

    Three distinct Enterococcus faecalis VanE-type isolates-BM4574, BM4575, and BM4576-obtained in Australia were studied. Expression of the resistance genes was constitutive in BM4575, probably due to a 2-bp deletion into the vanSE gene, and inducible in BM4574 and BM4576. Transcription analysis of the vanE operons suggested that the five genes were cotranscribed from an initiation site located 25 bp upstream from the ATG start codon of vanE.

  19. Van Swieten and the renaissance of the Vienna Medical School.

    PubMed

    Kidd, M; Modlin, I M

    2001-04-01

    The period until 1745 found the Viennese medical system languishing far behind advances made in other major European centers. This chaotic situation was reversed by the foresight and breadth of vision of the Empress Maria Theresa, who initiated considerable reform in Austria by actively recruiting the best minds of the time to reduce the intellectual and technologic differences. Her ability to entice one of Boerhaave's most eminent pupils, Gerard van Swieten, to leave Leiden for Vienna, particularly benefited the Vienna Medical School. In 1745 van Swieten assumed responsibility for reconfiguration of the patronage and nepotism-ridden medical system of the Austro-Hungarian Empire. As a first task, he swiftly expunged the influence of the Jesuits and other religious orders from medicine and established formal training and examinations, transforming the medical discipline into a meritocracy. Excelling as a physician and an innovative teacher, he also established a close personal relationship with the Empress and became her medical confidante. To a large part, the success of this first great Viennese medical school was owed to de Haen, who left Leiden to implement Boerhaave's method of clinical teaching. As a result of these innovations and with considerable support from the Empress, the University of Vienna, particularly its medical school, within a few decades achieved recognition throughout Europe as a seat of learning and scholarship. Van Swieten would not be remembered today if his contribution had been only scholarly or scientific achievements. He propelled Austrian medicine to a level commensurate with that of other European states of the day by 27 years of dedicated and industrious service.

  20. van Hove singularities in disordered multichannel quantum wires and nanotubes

    NASA Astrophysics Data System (ADS)

    Hügle, S.; Egger, R.

    2002-11-01

    We present a theory for the van Hove singularity (VHS) in the tunneling density of states (TDOS) of disordered multichannel quantum wires, in particular multiwall carbon nanotubes. We assume close-by gates that screen off electron-electron interactions. Diagrammatic perturbation theory within the noncrossing approximation yields analytical expressions governing the disorder-induced broadening and shift of VHS's as new subbands are opened. This problem is nontrivial because the (lowest-order) Born approximation breaks down close to the VHS. Interestingly, compared to the bulk case, the boundary TDOS shows drastically altered VHS's, even in the clean limit.

  1. The Van Fault, Eastern Turkey: A Preliminary Geological Slip Rate

    NASA Astrophysics Data System (ADS)

    Mackenzie, D.; Elliott, J. R.; Altunel, E.; Kurban, Y.; Walker, R. T.; Parsons, B.

    2014-12-01

    We present a preliminary quaternary slip-rate study on the Van fault, the source of the 2011 Mw7.1 reverse-slip earthquake which caused heavy damage to the cities of Van and Ercis, eastern Turkey. From the InSAR solution, we see a strong depth cut-off at 10km depth, above which there was no slip on the fault. We have carried out an investigation of the geomorphological expression of the fault in quaternary material, to determine whether the fault reaches the surface and, if so, whether this upper section could fail in an earthquake. On the western segment of the Van fault, we observe quaternary scarps coincident with the surface projection of the fault segment identified by InSAR, which displace quaternary alluvial fan and lake-bed deposits. These are coincident with the observation of fault gouge in quaternary deposits at a road cutting, providing evidence for a fault reaching the surface and suggesting that the upper section is capable of rupturing seismically. We use structure-from-motion photogrammetry, differential GPS and terrestrial LiDAR to determine offsets on two generations of fault scarps, and the creep offsets from the period following the earthquake. Preliminary radiocarbon and OSL dates from two uplifted terrace surfaces allow us to estimate a late quaternary geological slip-rate for the fault. Following the GPS and InSAR solution of Dogan et al. 2014 (GRL v41,i7), we also present field evidence and satellite image observations confirming the presence of a splay fault within the northern suburbs of Van city, which experienced creep following the 2011 earthquake. This fault is observed to be particularly evident in the early high resolution satellite imagery from the declassified CORONA missions, highlighting the potential for these datasets in identifying faults in areas now covered by urban sprawl. It remains unclear whether this fault could fail seismically. The fault which failed in 2011 is a north dipping reverse fault, unmapped prior to the

  2. Ellis-van Creveld Syndrome with Sagittal Craniosynostosis.

    PubMed

    Fischer, Andrew S; Weathers, William M; Wolfswinkel, Erik M; Bollo, Robert J; Hollier, Larry H; Buchanan, Edward P

    2015-06-01

    Ellis-van Creveld syndrome (EVC) is a rare disorder (the incidence is estimated at around 7/1,000,000) characterized by the clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia, and cardiac anomalies. Sagittal synostosis is characterized by a dolichocephalic head shape resulting from premature fusion of the sagittal suture. Both are rare disorders, which have never been reported together. We present a case of EVC and sagittal synostosis. We report the clinical features of a Hispanic boy with EVC and sagittal craniosynostosis who underwent cranial vault remodeling. The presentation of this patient is gone over in detail. A never before reported case of EVC and sagittal synostosis is presented in detail.

  3. van Leeuwenhoek microscopes-where are they now?

    PubMed

    Robertson, Lesley A

    2015-05-01

    When Antonie van Leeuwenhoek died, he left over 500 simple microscopes, aalkijkers (an adaption of his microscope to allow the examination of blood circulation in the tails of small eels) and lenses, yet now there are only 10 microscopes with a claim to being authentic, one possible aalkijker and six lenses. He made microscopes with more than one lens, and possibly three forms of the aalkijker. This paper attempts to establish exactly what he left and trace the fate of some of the others using the earliest possible documents and publications.

  4. 10. Whitney Arms Company, Van Slyck steel engraving, 1880 Photocopied ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Whitney Arms Company, Van Slyck steel engraving, 1880 Photocopied from Charles B. Norton, American Inventions and Improvements in Breech-Loading Small Arms (Springfield, Mass., 1880), p. 154 The engraving does not seem to have been included in the earlier 1872 edition. This is probably the single most widely copied view of the Whitney Arms Company works, and it is without doubt the most accurate. Compare with site plan, photo CT-2-13. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  5. De Hass-van Alphen effect in YBCO

    SciTech Connect

    Smith, J.L.; Fowler, C.M.; Freeman, B.L.; Hults, W.L.; King, J.C.; Mueller, F.M.

    1990-01-01

    Measurement of the de Haas-van Alphen effect in YBa{sub 2}Cu{sub 3}O{sub 6.97} in pulsed, magnetic fields peaking at 100 T in powdered material with the field applied along the c-axis reveal two pieces of the Fermi surface. Their cross sections are 0.56 kT (0.054 {angstrom}{sup {minus}2}) and 0.78 kT (0.075 {angstrom}{sup {minus}2}) with effective masses of 2.8 and 4.4 respectively.

  6. Ellis-van Creveld syndrome with facial hemiatrophy.

    PubMed

    Bhat, Yasmeen J; Baba, Asif Nazir; Manzoor, Sheikh; Qayoom, Seema; Javed, Sheikh; Ajaz, Hakeem

    2010-01-01

    Ellis-van Creveld (EVC) syndrome is a rare autosomal recessive congenital disorder characterized by chondrodysplasia and polydactyly, ectodermal dysplasia and congenital defects of the heart. We present here a case of a 16-year-old short-limbed dwarf with skeletal deformities and bilateral postaxial polydactyly, dysplastic nails and teeth, also having left-sided facial hemiatrophy. The diagnosis of EVC syndrome was made on the basis of clinical and radiological features. To the best of our knowledge, this is the first report of EVC syndrome with facial hemiatrophy in the medical literature from India.

  7. Ellis-van Creveld syndrome: A rare clinical entity.

    PubMed

    Kamal, Reet; Dahiya, Parveen; Kaur, Simerpreet; Bhardwaj, Rohit; Chaudhary, Karun

    2013-01-01

    Ellis-van Creveld (EVC) syndrome is a genetic disorder with autosomal recessive transmission, which may clinically present as small stature, short limbs, fine sparse hair, hypoplastic fingernails, multiple musculofibrous frenula, conical teeth, hypoplasia of the enamel, hypodontia, and malocclusion. Heart defects, especially abnormalities of atrial septation, have been found in about 60% of cases. The mutation in EVC and EVC2 gene is responsible for this syndrome. The presence of multiple orodental findings makes this syndrome important for dentists. The aim of this article is to present a rare case of EVC syndrome in a 10-year-old girl along with the review of literature.

  8. Van der Waals interaction between two crossed carbon nanotubes.

    PubMed

    Zhbanov, Alexander I; Pogorelov, Evgeny G; Chang, Yia-Chung

    2010-10-26

    The analytical expressions for the van der Waals potential energy and force between two crossed carbon nanotubes are presented. The Lennard-Jones potential between pairs of carbon atoms and the smeared-out approximation suggested by L. A. Girifalco (J. Phys. Chem. 1992, 96, 858) were used. The exact formula is expressed in terms of rational and elliptical functions. The potential and force for carbon nanotubes were calculated. The uniform potential curves for single- and multiwall nanotubes were plotted. The equilibrium distance, maximal attractive force, and potential energy have been evaluated.

  9. Van der Waals phase transition in the framework of holography

    NASA Astrophysics Data System (ADS)

    Zeng, Xiao-Xiong; Li, Li-Fang

    2017-01-01

    Phase structure of the quintessence Reissner-Nordström-AdS black hole is probed by the nonlocal observables such as holographic entanglement entropy and two point correlation function. Our result shows that, as the case of the thermal entropy, both the observables exhibit the Van der Waals-like phase transition. To reinforce this conclusion, we further check the equal area law for the first order phase transition and critical exponent of the heat capacity for the second order phase transition. We also discuss the effect of the state parameter on the phase structure of the nonlocal observables.

  10. Baseline tests of the power-train electric delivery van

    NASA Technical Reports Server (NTRS)

    Lumannick, S.; Dustin, M. O.; Bozek, J. M.

    1977-01-01

    Vehicle maximum speed, range at constant speed, range over stop-and-go driving schedules, maximum acceleration, gradeability, gradeability limit, road energy consumption, road power, indicated energy consumption, braking capability, battery charger efficiency, and battery characteristics were determined for a modified utility van powered by sixteen 6-volt batteries connected in series. A chopper controller actuated by a foot accelerator pedal changes the voltage applied to the 22-kilowatt (30-hp) series-wound drive motor. In addition to the conventional hydraulic braking system, the vehicle has hydraulic regenerative braking. Cycle tests and acceleration tests were conducted with and without hydraulic regeneration.

  11. Magnetic properties of tephras from Lake Van (Eastern Turkey)

    NASA Astrophysics Data System (ADS)

    Makaroglu, Ozlem; Caǧatay, Namık; Pesonen, Lauri J.; Orbay, Naci

    2013-04-01

    Here we present magnetic properties of tephra layers in the cores taken from Lake Van, Eastern Anatolia, Turkey. Lake Van is the fourth largest terminal Lake in the world by volume (607 km3). It is 460 m deep and has a salinity of 21.4 per mil and a pH of 9.81. It is located on the East Anatolian Plateau with present day water level of 1648 m.a.s.l., and surrounded by large stratovolcanoes Nemrut, Suphan, Tendurek, and Ararat to the west and north. It has accumulated varved-sediments with tephra units, which all provide important paleoenvironmental records. After a seismic survey, four different locations were selected for coring in Lake Van, with water depths varying between 60 m and 90 m. Four cores having between 3 and 4.8 m length were analyzed for for element geochemistry using XRF Core Scanner analysis. The sub-samples were taken into plastic boxes with a volume of 6.4 cm3 for mineral magnetic analysis. The mineral magnetic measurements included magnetic susceptibility (χ), anhysteretic remanent magnetisation (ARM), isothermal remanent magnetisation (IRM), hysteresis properties and thermomagnetic analyses. According to the mineral magnetic measurements and geochemical analysis, we identified the five tephra layers (T1-T5). These tephra units were correlated with the previously varve-dated units of Landmann et al. (2011). The varve ages of the tephra layers were used to obtain the age-depth model for the cores. According to the age models the cores extend back to 9500 ka BP (varve years). Down-core profiles of all the magnetic properties are highly correlatable between different cores, suggesting that the magnetic records are of regional character. ARM values are found to be more convenient than χ values for correlating the tephra layers. The hysteresis parameters of samples taken from these layers indicate that they are within Pseudo Single Domain range. IRM curves show that low coersivity magnetic minerals are dominated in all tephra layers. Measurements

  12. Ellis-van Creveld syndrome: A rare clinical entity

    PubMed Central

    Kamal, Reet; Dahiya, Parveen; Kaur, Simerpreet; Bhardwaj, Rohit; Chaudhary, Karun

    2013-01-01

    Ellis-van Creveld (EVC) syndrome is a genetic disorder with autosomal recessive transmission, which may clinically present as small stature, short limbs, fine sparse hair, hypoplastic fingernails, multiple musculofibrous frenula, conical teeth, hypoplasia of the enamel, hypodontia, and malocclusion. Heart defects, especially abnormalities of atrial septation, have been found in about 60% of cases. The mutation in EVC and EVC2 gene is responsible for this syndrome. The presence of multiple orodental findings makes this syndrome important for dentists. The aim of this article is to present a rare case of EVC syndrome in a 10-year-old girl along with the review of literature. PMID:23798848

  13. Spherical and hyperspherical harmonics representation of van der Waals aggregates

    NASA Astrophysics Data System (ADS)

    Lombardi, Andrea; Palazzetti, Federico; Aquilanti, Vincenzo; Grossi, Gaia; Albernaz, Alessandra F.; Barreto, Patricia R. P.; Cruz, Ana Claudia P. S.

    2016-12-01

    The representation of the potential energy surfaces of atom-molecule or molecular dimers interactions should account faithfully for the symmetry properties of the systems, preserving at the same time a compact analytical form. To this aim, the choice of a proper set of coordinates is a necessary precondition. Here we illustrate a description in terms of hyperspherical coordinates and the expansion of the intermolecular interaction energy in terms of hypersherical harmonics, as a general method for building potential energy surfaces suitable for molecular dynamics simulations of van der Waals aggregates. Examples for the prototypical case diatomic-molecule-diatomic-molecule interactions are shown.

  14. Slidable atomic layers in van der Waals heterostructures

    NASA Astrophysics Data System (ADS)

    Kobayashi, Yu; Taniguchi, Takashi; Watanabe, Kenji; Maniwa, Yutaka; Miyata, Yasumitsu

    2017-04-01

    We report the preparation and manipulation of slidable atomic layers in clean, incommensurate van der Waals (vdW) heterostructures. Monolayer and multilayer WS2 grains are grown on graphite and hexagonal boron nitride (hBN) via chemical vapor deposition, and these grains can slide smoothly on graphite and hBN surfaces by manipulation with a tip. Furthermore, this sliding process allows the suspension, tearing, stacking, and connection of the atomic layers. These results demonstrate a novel approach for developing a wide variety of atomic-layer heterostructures with tunable interlayer coupling and an ideal system for studying the superlubricity of incommensurate, highly clean vdW contacts.

  15. Gebruikershandleiding en Programmatuurbeschrijving van het Data Acquisitie Systeem van het Laboratorium voor Pulsfysica (User Manual and Program Description of the Data Acquisition System of PML-Pulse Physics)

    DTIC Science & Technology

    1993-01-01

    Ingangsbereik t 100 mV - ±50V voile schaal in een 1-2-5 volgorde; - Ingangsimpedanrie :M11 11 45 pF; - Ingangsmode Single / Differential...manier van meten kan hier single of differential ingesteld worden; - Input coupling AC/DC; - Range Hier kan een bereik worden ingevuld van 100 mV - 50...de ingangsimpedantie op 1 M12 of 50 0l worden ingesteld; Input coupling AC / DC; Range Hier kan een bereik worden ingesteld van 50 mV - 20 V voile

  16. Softwaremodule voor het Simuleren van de Gevolgen van Raketonderschepping (The Dutch Program for the Simulation of Missile Intercept Effects)

    DTIC Science & Technology

    2007-07-01

    exernplaar van het rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie bijgeleverd op cd-romn 2/3 DMO/DR&D/Kennistransfer 4 DM0/ Directie Beleid...MPH 10 CDC/BGGZ/CEMG A.S. de Koning. arts standaard inclusief digitale versie bijgeleverd op cd-rom 11/12 DMIVD, Kabinet 13 Militaire Inlichtingen- en...Veiligheidsdienst Drs. E. Buijs 14 BS/DS/DOBBP/B Maj B. Doesburg-Smits 15 CJKC NBC, Ltkol C.A. Bourgondi n standaard inclusief digitale versie

  17. van der Waals forces influencing adhesion of cells

    PubMed Central

    Kendall, K.; Roberts, A. D.

    2015-01-01

    Adhesion molecules, often thought to be acting by a ‘lock and key’ mechanism, have been thought to control the adhesion of cells. While there is no doubt that a coating of adhesion molecules such as fibronectin on a surface affects cell adhesion, this paper aims to show that such surface contamination is only one factor in the equation. Starting from the baseline idea that van der Waals force is a ubiquitous attraction between all molecules, and thereby must contribute to cell adhesion, it is clear that effects from geometry, elasticity and surface molecules must all add on to the basic cell attractive force. These effects of geometry, elasticity and surface molecules are analysed. The adhesion force measured between macroscopic polymer spheres was found to be strongest when the surfaces were absolutely smooth and clean, with no projecting protruberances. Values of the measured surface energy were then about 35 mJ m−2, as expected for van der Waals attractions between the non-polar molecules. Surface projections such as abrasion roughness or dust reduced the molecular adhesion substantially. Water cut the measured surface energy to 3.4 mJ m−2. Surface active molecules lowered the adhesion still further to less than 0.3 mJ m−2. These observations do not support the lock and key concept. PMID:25533101

  18. Upscaled soil-water retention using van Genuchten's function

    USGS Publications Warehouse

    Green, T.R.; Constantz, J.E.; Freyberg, D.L.

    1996-01-01

    Soils are often layered at scales smaller than the block size used in numerical and conceptual models of variably saturated flow. Consequently, the small-scale variability in water content within each block must be homogenized (upscaled). Laboratory results have shown that a linear volume average (LVA) of water content at a uniform suction is a good approximation to measured water contents in heterogeneous cores. Here, we upscale water contents using van Genuchten's function for both the local and upscaled soil-water-retention characteristics. The van Genuchten (vG) function compares favorably with LVA results, laboratory experiments under hydrostatic conditions in 3-cm cores, and numerical simulations of large-scale gravity drainage. Our method yields upscaled vG parameter values by fitting the vG curve to the LVA of water contents at various suction values. In practice, it is more efficient to compute direct averages of the local vG parameter values. Nonlinear power averages quantify a feasible range of values for each upscaled vG shape parameter; upscaled values of N are consistently less than the harmonic means, reflecting broad pore-size distributions of the upscaled soils. The vG function is useful for modeling soil-water retention at large scales, and these results provide guidance for its application.

  19. Leon Van Speybroeck Wins Astrophysics Bruno Rossi Prize

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Leon Van Speybroeck of the Harvard-Smithsonian Center for Astrophysics in Cambridge Massachusetts was awarded the 2002 Bruno Rossi Prize of the High-Energy Astrophysics Division of the American Astronomy Society. The Rossi Prize is an arnual recognition of significant contributions in high-energy astrophysics in honor of the Massachusetts Institute of Technology's late Professor Bruno Rossi, an authority on cosmic ray physics and a pioneer in the field of x-ray astronomy. Van Speybroeck, who led the effort to design and make the x-ray mirrors for NASA's premier Chandra X-Ray Observatory, was recognized for a career of stellar achievements in designing precision x-ray optics. As Telescope Scientist for Chandra, he has worked for more than 20 years with a team that includes scientists and engineers from the Harvard-Smithsonian, NASA's Marshall Space Flight Center, TRW, Inc., Huhes-Danbury (now B.F. Goodrich Aerospace), Optical Coating Laboratories, Inc., and Eastman-Kodak on all aspects of the x-ray mirror assembly that is the heart of the observatory.

  20. Van der Waals Epitaxy of Ultrathin Halide Perovkistes

    NASA Astrophysics Data System (ADS)

    Wang, Yiping; Shi, Yunfeng; Shi, Jian

    We present our understanding, with CH3NH3PbX3 as a model system, on the 2D van der Waals growth and kinetics of 3D parent materials. We show the successful synthesis of ultrathin (sub-10 nm), large scale (a few tens of μm) single crystalline 2D perovskite thin films on layered mica substrate by van der Waals (VDW) epitaxy. Classical nucleation and growth model explaining conventional epitaxy has been modified to interpret the unique 2D results under VDW mechanism. The generalization of our model shows that a 3D crystal with low cohesive energy tends to favor the 2D growth while the one with strong cohesive energy has less kinetic window. With Monte Carlo simulations, we show that the fractal 2D morphology in perovskite precisely manifests the kinetic competition between VDW diffusivity and thermodynamic driving force, a unique phenomenon to VDW growth, suggesting a fundamental limit on the morphology stability of the 2D form of a 3D material. On the other hand, our single crystal thin film growth results and subsequent cryogenic study in the iodide perovskite provide a perfect resource for the exploration of its complex optical and electronic properties and unveiling the origins of its popularity in the energy conversion field.

  1. Franckeite as a naturally occurring van der Waals heterostructure

    PubMed Central

    Molina-Mendoza, Aday J.; Giovanelli, Emerson; Paz, Wendel S.; Niño, Miguel Angel; Island, Joshua O.; Evangeli, Charalambos; Aballe, Lucía; Foerster, Michael; van der Zant, Herre S. J.; Rubio-Bollinger, Gabino; Agraït, Nicolás; Palacios, J. J.; Pérez, Emilio M.; Castellanos-Gomez, Andres

    2017-01-01

    The fabrication of van der Waals heterostructures, artificial materials assembled by individual stacking of 2D layers, is among the most promising directions in 2D materials research. Until now, the most widespread approach to stack 2D layers relies on deterministic placement methods, which are cumbersome and tend to suffer from poor control over the lattice orientations and the presence of unwanted interlayer adsorbates. Here, we present a different approach to fabricate ultrathin heterostructures by exfoliation of bulk franckeite which is a naturally occurring and air stable van der Waals heterostructure (composed of alternating SnS2-like and PbS-like layers stacked on top of each other). Presenting both an attractive narrow bandgap (<0.7 eV) and p-type doping, we find that the material can be exfoliated both mechanically and chemically down to few-layer thicknesses. We present extensive theoretical and experimental characterizations of the material's electronic properties and crystal structure, and explore applications for near-infrared photodetectors. PMID:28194037

  2. Preserving the History of Wesleyan University's Van Vleck Observatory

    NASA Astrophysics Data System (ADS)

    Kilgard, Roy E.; Erickson, Paul; Herbst, William; Redfield, Seth; Williams, Amrys

    2016-01-01

    Since its opening in 1916, the Van Vleck Observatory at Wesleyan University has been dedicated to the joint mission of astronomical education and research. In celebration of the Observatory's centennial year, we are undertaking a number of projects to preserve and chronicle its history. The centerpiece of these efforts has been the renovation of the 20-inch Alvan Clark refracting telescope. Through careful compromise of historical restoration and modernization, we have ensured the future of one of the nation's last large, long-focus refractors well into the 21st century. In addition, we are producing an historical exhibition in the Observatory and online that will open to the public in the spring of 2016. Our exhibition explores the place-based nature of astronomical research, the scientific instruments, labor, and individuals that have connected places around the world in networks of observation, and the broader history of how observational astronomy has linked local people, amateur observers, professional astronomers, and the tools and objects that have facilitated their work under Connecticut's skies over the past 100 years. We are also collecting memories from the community to enrich our exhibition. If you have a story about the Van Vleck Observatory you would like to share with our researchers, please contact one of the authors.

  3. [Trait-aggression and suicide of Vincent van Gogh].

    PubMed

    Pezenhoffer, Ibolya; Gerevich, József

    2015-01-01

    Although in recent decades the literature has paid special attention to Vincent van Gogh's life, work and illness, there has still not been an examination of the connections between his trait aggression and his suicide. The present study traces, in the light of this trait aggression, the predictive factors that can be observed on the path leading to the artist's suicide. Biographical documents, case history data, as well as letters and the findings of earlier research have been used in the course of the analysis. Among the distal suicide risk factors we find a positive family anamnesis, childhood traumas (emotional deprivation, identity problems associated with the name Vincent), a vagrant, homeless way of life, failures in relationships with women, and psychotic episodes appearing in rushes. The proximal factors include the tragic friendship with Gauguin (frustrated love), his brother Theo's marriage (experienced as a loss), and a tendency to self-destruction. Both factor groups on the one hand determined the course of development of the trait aggression and on the other can also be regarded as a manifestation of that trait aggression. It can be said that the trait aggression played an important role in Van Gogh's suicide.

  4. [Van Leeuwenhoek's discovery of bacteria: a look too far ahead].

    PubMed

    James, J

    2004-12-25

    During the 17th century microscopy was practised at the Royal Society in London by the curator Robert Hooke (1635-1703). He made use of the compound microscope (with uncorrected lenses) and published a book describing the most varied observations of botanical and animal specimens, among which he introduced the concept of 'cellula', observed in botanical material. The useful magnification was limited to 30-40 times. During the same period, the passionate amateur Anthonie van Leeuwenhoek in Delft (1632-1723) was engaged in microscopy, using a so-called simple microscope which was difficult to use but could be applied--albeit with a greater effort--at a much larger aperture so that magnifications in the range of 75-150 times were feasible. Using these self-made instruments, Van Leeuwenhoek was able to observe and describe bacteria, but this could not be confirmed at the Royal Society. It took 150 years before the compound microscope reached this level and bacteria were recognized as pathogenic organisms.

  5. A van der Waals DFT Approach to Modeling Water

    NASA Astrophysics Data System (ADS)

    Kolb, Brian; Thonhauser, Timo

    2010-03-01

    We present density functional theory calculations for small water clusters and bulk water including van der Waals interactions via the non-local functional vdW-DF [1]. Historically, standard functionals such as LDA or GGA have been unable to accurately predict vibrational frequencies of small water clusters or the freezing point of bulk water, which has been partly attributed to the lack of van der Waals interactions [2]. We have implemented vdW-DF in the PWscf package, using an efficient convolution approach [3]. Our results for the vibrational frequencies of small water clusters show that vdW-DF gives a significant improvement compared to LDA or GGA. While the discrepancy between experiment and LDA/GGA is as much as 28% for certain modes, vdW-DF reduces this error to only about 6%. We also present results for the vibrational spectrum and Raman spectrum of periodic ice, again showing the advantages of vdW-DF. In addition, we show preliminary results for bulk water from our vdW-DF MD simulations.[4pt] [1] Thonhauser et al., Phys. Rev. B 76, 125112 (2007).[2] H. Sit and N. Marzari, J. Chem. Phys. 122, 204510 (2005). [3] G. Roman-Perez and J. Soler, Phys. Rev. Lett. 103, 096102 (2009).

  6. Franckeite as a naturally occurring van der Waals heterostructure.

    PubMed

    Molina-Mendoza, Aday J; Giovanelli, Emerson; Paz, Wendel S; Niño, Miguel Angel; Island, Joshua O; Evangeli, Charalambos; Aballe, Lucía; Foerster, Michael; van der Zant, Herre S J; Rubio-Bollinger, Gabino; Agraït, Nicolás; Palacios, J J; Pérez, Emilio M; Castellanos-Gomez, Andres

    2017-02-13

    The fabrication of van der Waals heterostructures, artificial materials assembled by individual stacking of 2D layers, is among the most promising directions in 2D materials research. Until now, the most widespread approach to stack 2D layers relies on deterministic placement methods, which are cumbersome and tend to suffer from poor control over the lattice orientations and the presence of unwanted interlayer adsorbates. Here, we present a different approach to fabricate ultrathin heterostructures by exfoliation of bulk franckeite which is a naturally occurring and air stable van der Waals heterostructure (composed of alternating SnS2-like and PbS-like layers stacked on top of each other). Presenting both an attractive narrow bandgap (<0.7 eV) and p-type doping, we find that the material can be exfoliated both mechanically and chemically down to few-layer thicknesses. We present extensive theoretical and experimental characterizations of the material's electronic properties and crystal structure, and explore applications for near-infrared photodetectors.

  7. Van Allen Probes Observations of Direct Wave Particle Interactions

    NASA Astrophysics Data System (ADS)

    Fennell, J. F.; Roeder, J. L.; Kurth, W. S.; Henderson, M. G.; Larsen, B.; Hospodarsky, G. B.; Blake, J. B.; Claudepierre, S. G.; Clemmons, J. H.; Spence, H.; Funsten, H. O.; Reeves, G. D.; Kletzing, C.; Wygant, J. R.

    2013-12-01

    We present observations of wave-particle interactions observed on the Van Allen Probes during an interval of sporadic increases or bursts of 20-30 keV electron fluxes observed in conjunction with bursts of chorus activity. The electron flux and chorus burst occurred on a nearly one for one basis during an hour interval on January 13, 2013. The electron angular distributions changed during the burst events such that flux increases evolved from Sinn(α) type angular distributions to form maxima in the electron angular distributions at 75-80° local pitch angle with the fluxes at 90° and <60° remaining the same as in the pre and post burst distributions. These events occurred well outside the plasmasphere following a minor plasma injection. They were observed on both Van Allen Probes spacecraft, which were relatively close together. The plasma density, electron gyro-frequency and pitch angle of peak flux in a burst was used to estimate the resonant electron energy. The result of ~25 keV is consistent with the energies of the electrons showing the flux enhancements observed by the ECT/MagEIS and ECT/HOPE spectrometers. These results will be described in detail and questions concerning the source of such events will be discussed.

  8. Vincent van Gogh (1853-90): the plumbic artist.

    PubMed

    Weissman, Edward

    2008-05-01

    Following Vincent van Gogh's death in 1890, numerous physicians have offered diagnostic opinions regarding his still unverified illness. The discovery that he had ingested leaded oil paints prompted research that revealed his exposure to additional sources of lead and other toxic substances for 13 years before death. His complaints, derived from poignant letters to his brother, added compelling evidence that he had suffered neurotoxicity, encephalopathy and other consequences of lead. Vincent's suicide may have been precipitated by plumbism. Mankind has endured lead's presence for millennia, yet its destructive effects have been recognized sporadically. That symptoms of plumbism mimic other illnesses should prod a heightened index of suspicion. Had it not been for the financial and emotional support of Vincent by his brother, Theo, and the dedication of the latter's wife, Johanna, the artist's genius might never have been recognized. Widowed by the death of her husband six months after Vincent's demise, Johanna(1) remained the guardian of the painter's extraordinary artistic and literary output until critical acclaim established him as one of Europe's greatest artists. Her efforts, assisted by her son, in framing and exhibiting van Gogh's works, were crucial. She then translated and systematized his more than 750 letters to Theo, their sister, Willemien, their mother, fellow artists and others.(2).

  9. Two-dimensional van der Waals C60 molecular crystal

    PubMed Central

    Reddy, C. D.; Gen Yu, Zhi; Zhang, Yong-Wei

    2015-01-01

    Two-dimensional (2D) atomic crystals, such as graphene and transition metal dichalcogenides et al. have drawn extraordinary attention recently. For these 2D materials, atoms within their monolayer are covalently bonded. An interesting question arises: Can molecules form a 2D monolayer crystal via van der Waals interactions? Here, we first study the structural stability of a free-standing infinite C60 molecular monolayer using molecular dynamic simulations, and find that the monolayer is stable up to 600 K. We further study the mechanical properties of the monolayer, and find that the elastic modulus, ultimate tensile stress and failure strain are 55–100 GPa, 90–155 MPa, and 1.5–2.3%, respectively, depending on the stretching orientation. The monolayer fails due to shearing and cavitation under uniaxial tensile loading. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of the monolayer are found to be delocalized and as a result, the band gap is reduced to only 60% of the isolated C60 molecule. Interestingly, this band gap can be tuned up to ±30% using strain engineering. Owing to its thermal stability, low density, strain-tunable semi-conducting characteristics and large bending flexibility, this van der Waals molecular monolayer crystal presents aplenty opportunities for developing novel applications in nanoelectronics. PMID:26183501

  10. Tectono-Stratigraphic Evolution of the Lake Van, Turkey

    NASA Astrophysics Data System (ADS)

    Görür, Naci; Sakınç, Mehmet; Zabcı, Cengiz; Namık Çaǧatay, M.; Akkök, Remzi; Şile, Hande

    2014-05-01

    Lake Van is situated in eastern Anatolia. It is the largest soda lake in the world. It also ranks the fourth-lake on earth by volume. It formed during the Pleistocene when the volcanic edifice of the Nemrut Volcano locally blocked the valley of the River Euphrates. It has a closed drainage system with several perennial streams that carry large amounts of sediments from the surrounding high mountains and accumulate them in today's lake. However, these sediments also crop out as terraces at various altitudes of the surrounding elevated areas, indicating that a series of changes in base- or water-level of the lake occurred. The exposed sediments display characteristic facies, stratigraphic sequence, well-developed sedimentary structures and scattered fossils that provide invaluable data on physical, chemical and biological conditions of their depositional sub-environments. Recognition of these sub-environments and their arrangement in space and time may contribute tremendously to our understanding of local tectonics and paleoclimate of the Lake Van Basin. These presentation deals with such topics.

  11. Geologic environment of the Van Norman Reservoirs area

    USGS Publications Warehouse

    Yerkes, R.F.; Bonilla, M.G.; Youd, T.L.; Sims, J.D.

    1974-01-01

    The upper and lower Van Norman dams, in northwesternmost San Fernando Valley about 20 mi (32 km) northwest of downtown Los Angeles, were severely damaged during the 1971 San Fernando earthquake. An investigation of the geologic-seismologic setting of the Van Norman area indicates that an earthquake of at least M 7.7 may be expected in the Van Norman area. The expectable transitory effects in the Van Norman area of such an earthquake are as follows: peak horizontal acceleration of at least 1.15 g, peak velocity of displacement of 4.43 ft/sec (135 cm/sec), peak displacement of 2.3 ft (70 cm), and duration of shaking at accelerations greater than 0.05 g, 40 sec. A great earthquake (M 8+) on the San Andreas fault, 25 mi distant, also is expectable. Transitory effects in the Van Norman area from such an earthquake are estimated as follows: peak horizontal acceleration of 0.5 g, peak velocity of 1.97 ft/sec (60 cm/sec), displacement of 1.31 ft (40 cm), and duration of shaking at accelerations greater than 0.05 g, 80 sec. The permanent effects of the expectable local earthquake could include simultaneous fault movement at the lower damsite, the upper damsite, and the site proposed for a replacement dam halfway between the upper and lower dams. The maximum differential displacements due to such movements are estimated at 16.4 ft (5 m) at the lower damsite and about 9.6 ft (2.93 m) at the upper and proposed damsites. The 1971 San Fernando earthquake (M 6?) was accompanied by the most intense ground motions ever recorded instrumentally for a natural earthquake. At the lower Van Norman dam, horizontal accelerations exceeded 0.6 g, and shaking greater than 0.25 g lasted for about 13 see; at Pacoima dam, 6 mi (10 km) northeast of the lower dam, high-frequency peak horizontal accelerations of 1.25 g were recorded in two directions, and shaking greater than 0.25 g lasted for about 7 sec. Permanent effects of the earthquake include slope failures in the embankments of the upper

  12. Franckeite as a naturally occurring van der Waals heterostructure

    NASA Astrophysics Data System (ADS)

    Molina-Mendoza, Aday J.; Giovanelli, Emerson; Paz, Wendel S.; Niño, Miguel Angel; Island, Joshua O.; Evangeli, Charalambos; Aballe, Lucía; Foerster, Michael; van der Zant, Herre S. J.; Rubio-Bollinger, Gabino; Agraït, Nicolás; Palacios, J. J.; Pérez, Emilio M.; Castellanos-Gomez, Andres

    2017-02-01

    The fabrication of van der Waals heterostructures, artificial materials assembled by individual stacking of 2D layers, is among the most promising directions in 2D materials research. Until now, the most widespread approach to stack 2D layers relies on deterministic placement methods, which are cumbersome and tend to suffer from poor control over the lattice orientations and the presence of unwanted interlayer adsorbates. Here, we present a different approach to fabricate ultrathin heterostructures by exfoliation of bulk franckeite which is a naturally occurring and air stable van der Waals heterostructure (composed of alternating SnS2-like and PbS-like layers stacked on top of each other). Presenting both an attractive narrow bandgap (<0.7 eV) and p-type doping, we find that the material can be exfoliated both mechanically and chemically down to few-layer thicknesses. We present extensive theoretical and experimental characterizations of the material's electronic properties and crystal structure, and explore applications for near-infrared photodetectors.

  13. MA-9 ASTRONAUT L. GORDON COOPER LEAVES TRANSFER VAN AT LAUNCH COMPLEX 14

    NASA Technical Reports Server (NTRS)

    1963-01-01

    MA-9 ASTRONAUT L. GORDON COOPER LEAVES TRANSFER VAN AT LAUNCH COMPLEX 14 S-63-6247 P-07136, ARCHIVE-03808 Astronaut L. Gordon Cooper, Jr., leaves the transfer van at Pad #14 for his ride up the gantry elevator to the 11th deck where he will be inserted into the spacecraft for his 22-orbit mission.

  14. Joyce VanTassel-Baska: The Talent Development of a Researcher

    ERIC Educational Resources Information Center

    Henshon, Suzanna E.

    2007-01-01

    Dr. Joyce VanTassel-Baska is the Executive Director of the Center for Gifted Education at The College of William & Mary in Williamsburg, VA. She is the current president of the National Association for Gifted Children. Prior to coming to William & Mary, Dr. VanTassel-Baska founded and directed the Center for Talent Development at Northwestern…

  15. 78 FR 28947 - Fund Availability Under VA's Homeless Providers Grant and Per Diem Program (VANS)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... CFR 61.1. Authority: Funding applied for under this Notice is authorized by title 38 U.S.C. 2011, 2012... section sets forth provisions for obtaining a van capital grant under 38 U.S.C. 2011. In addition to being... AFFAIRS Fund Availability Under VA's Homeless Providers Grant and Per Diem Program (VANS)...

  16. Early Childhood Matters: The Bulletin of the Bernard van Leer Foundation, 1998.

    ERIC Educational Resources Information Center

    Smale, Jim, Ed.

    1998-01-01

    This document consists of the three 1998 issues of The Bernard van Leer Foundations'"Early Childhood Matters." This periodical, addressed to practitioners in the field of early childhood development, evolved from an in-house publication directed to projects funded by the Bernard van Leer Foundation. Articles in the February 1998 edition…

  17. Development of osmoregulatory tissues in the Lake van fish (Alburnus tarichi) during larval development.

    PubMed

    Oğuz, Ahmet R

    2017-09-27

    Lake Van is one of the largest alkaline lakes worldwide and Lake Van Fish (Alburnus tarichi Güldenstädt, 1814) is the only vertebrate species inhabiting it. Lake Van Fish is an anadromous species that migrates to the streams (salinity 0.02%, pH 8.42) flowing into Lake Van (salinity 0.22%, pH 9.8) during the spawning period (April-July). Following spawning, fish return to Lake Van while larvae remain in fresh water. This study examined the development of osmoregulatory organs and the distribution of ionocytes in Lake Van Fish larvae adapting to the highly alkaline water characterizing the lake. Ionocytes were marked immunohistochemically and observed in whole mounts with immunofluorescence staining using the Na(+)/K(+) ATPase antibody. Ionocytes were first identified in the yolk sac membrane and skin, and then in the gills, digestive tract, and kidneys of larvae. The number of ionocytes on yolk sac membrane and skin decreased during larval development, indicating ionocytes on these tissues have a role in larvae osmoregulation. Larvae hatched from eggs in stream waters die when transferred to Lake Van water but survived in lake water diluted with deionized water. Thus, larvae need to go through certain alterations at the cellular and organ levels in order to adapt to the conditions of Lake Van water, indicating they do not enter this lake immediately after hatching.

  18. 49 CFR 393.128 - What are the rules for securing automobiles, light trucks and vans?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false What are the rules for securing automobiles, light... automobiles, light trucks and vans? (a) Applicability. The rules in this section apply to the transportation of automobiles, light trucks, and vans which individually weigh 4,536 kg. (10,000 lb) or...

  19. 49 CFR 393.128 - What are the rules for securing automobiles, light trucks and vans?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false What are the rules for securing automobiles, light... automobiles, light trucks and vans? (a) Applicability. The rules in this section apply to the transportation of automobiles, light trucks, and vans which individually weigh 4,536 kg. (10,000 lb) or...

  20. 49 CFR 393.128 - What are the rules for securing automobiles, light trucks and vans?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false What are the rules for securing automobiles, light... automobiles, light trucks and vans? (a) Applicability. The rules in this section apply to the transportation of automobiles, light trucks, and vans which individually weigh 4,536 kg. (10,000 lb) or...

  1. 49 CFR 393.128 - What are the rules for securing automobiles, light trucks and vans?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false What are the rules for securing automobiles, light... automobiles, light trucks and vans? (a) Applicability. The rules in this section apply to the transportation of automobiles, light trucks, and vans which individually weigh 4,536 kg. (10,000 lb) or...

  2. Cylinders and Seances: Elise van Calcar and the Spirit of Froebel

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2013-01-01

    This essay discusses the life and work of Elise van Calcar (1822-1904), a writer and maternal feminist who introduced Froebel's kindergarten in the Netherlands. Van Calcar also was the leader of a Christian branch of spiritualism. The focus is pointed at parallels between her reading of Froebel and of "messages" from spirits in the…

  3. 77 FR 28924 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel VAN'S CATCH TWO; Invitation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Maritime Administration Requested Administrative Waiver of the Coastwise Trade Laws: Vessel VAN'S CATCH TWO... the vessel VAN'S CATCH TWO is: Intended Commercial Use of Vessel: ``Sport Fishing Charter...

  4. Psychologische Operaties: de theorie van Gedragsbeinvloeding (Psychological Operations: The Theory of Behavioral Influence)

    DTIC Science & Technology

    2006-08-01

    of persoonlijke vaardigbeden. Diffusie van informatie en invloed via sociale netiverken Vaak wordt verondersteld dat de invloed van de media verloopt...R. (2002). Social and psychological effects of information technologies and other interactive media . Bryant, J., Zillmann, D., and editors. Media ...menselijk gedrag. Men onder- zoekt bijvoorbeeld de wijze waarop mensen waarnemen en de samenhang tussen waarneming, cognities en gedrag. De sociale

  5. Cylinders and Seances: Elise van Calcar and the Spirit of Froebel

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2013-01-01

    This essay discusses the life and work of Elise van Calcar (1822-1904), a writer and maternal feminist who introduced Froebel's kindergarten in the Netherlands. Van Calcar also was the leader of a Christian branch of spiritualism. The focus is pointed at parallels between her reading of Froebel and of "messages" from spirits in the…

  6. Willem van de Wall: Organizer and Innovator in Music Education and Music Therapy.

    ERIC Educational Resources Information Center

    Clair, Alicia Ann; Heller, George N.

    1989-01-01

    Examines Willem van de Wall's historically significant contributions to seminal literature on music therapy and the influence of music on behavior. Reviews van de Wall's early writings, at his work on music for children, and on music in institutions. Cites his "Music in Hospitals" as the culmination of his work in music therapy, music…

  7. Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"

    ERIC Educational Resources Information Center

    Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

    2009-01-01

    The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

  8. Are Fast Interceptive Actions Continuously Guided by Vision? Revisiting Bootsma and van Wieringen (1990)

    ERIC Educational Resources Information Center

    van Soest, A. J.; Casius, L. J. R.; de Kok, W.; Krijger, M.; Meeder, M.; Beek, P. J.

    2010-01-01

    In an influential study, R. J. Bootsma and P. C. W. van Wieringen (1990) argued that 2 of their 5 participants used visual information continuously during the attacking forehand drive in table tennis, its brief duration vis-a-vis the visuomotor delay notwithstanding. The authors repeated Bootsma and van Wieringen's experiment and included a…

  9. 75 FR 54692 - Culturally Significant Objects Imported for Exhibition Determinations: “Van Gogh, Gauguin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Van Gogh, Gauguin, C zanne, and... that the objects to be included in the exhibition ``Van Gogh, Gauguin, C zanne, and Beyond: Post...

  10. Kwaliteit van Expertsystemen: Algoritmen voor Integriteits-Controle (Quality of Expert Systems: Algorithms for Integrity Control)

    DTIC Science & Technology

    1990-03-01

    gelegd kan worden tussen de gebanteerde ontwikkelmetbode en algoritmen voor integriteitscontrole. In concreto komt dit neer op: * Evaluatie van...feiten) te bepalen am de beperkingsregels te kunnen lacaliseren die getvalueeiti moeten warden. In concreto moeten twee feitenverzamelingen warden...gebanteerd worden. Consistentie bij Suwa komt in concreto neer op bet detecteren van drie soorten ’potentible fouten’ in de kennisbank: tegenstrijdigbeid

  11. The Educational Thought of Cornelius Van Til: Philosophical Foundations of the Contemporary Christian School Movement.

    ERIC Educational Resources Information Center

    Maffet, Gregory J.; Dye, Charles M.

    This paper gives an account of the thoughts of Cornelius Van Til on the contemporary Christian school movement. An account of the historical development of Christian compromise is given, followed by a critique of the compromise among contemporary Christian educators. Van Til claims that any educational position which falls short of being founded…

  12. Validity of Dietary Restraint Scales: Reply to van Strien et al. (2006)

    ERIC Educational Resources Information Center

    Stice, Eric; Presnell, Katherine; Lowe, Michael R.; Burton, Emily

    2006-01-01

    In T. van Strien, R. C. M. E. Engels, W. van Staveren, and C. P. Herman's (see record 2006-03905-010) comment, they contested the conclusion that dietary restraint scales are invalid measures of acute dietary restriction (E. Stice, M. Fisher, & M. R. Lowe, 2004). The authors respond to their concerns and conclude that researchers should (a) not…

  13. Community Music during the New Deal: The Contributions of Willem Van de Wall and Max Kaplan

    ERIC Educational Resources Information Center

    Krikun, Andrew

    2010-01-01

    Willem Van de Wall (1887-1953) and Max Kaplan (1911-98) built careers spanning music performance, music education, adult education, sociology, social work, music therapy and community music. Willem Van de Wall was a seminal influence on the development of the fields of music therapy and adult education--researching the role of music in…

  14. Are Fast Interceptive Actions Continuously Guided by Vision? Revisiting Bootsma and van Wieringen (1990)

    ERIC Educational Resources Information Center

    van Soest, A. J.; Casius, L. J. R.; de Kok, W.; Krijger, M.; Meeder, M.; Beek, P. J.

    2010-01-01

    In an influential study, R. J. Bootsma and P. C. W. van Wieringen (1990) argued that 2 of their 5 participants used visual information continuously during the attacking forehand drive in table tennis, its brief duration vis-a-vis the visuomotor delay notwithstanding. The authors repeated Bootsma and van Wieringen's experiment and included a…

  15. Early Childhood Matters: The Bulletin of the Bernard van Leer Foundation, 2000.

    ERIC Educational Resources Information Center

    Smale, Jim, Ed.

    2000-01-01

    This document consists of the three 2000 issues of The Bernard van Leer Foundation's "Early Childhood Matters." This periodical, addressed to practitioners in the field of early childhood education, evolved from an in-house publication directed to projects funded by the Bernard van Leer Foundation. Articles in the February 2000 edition…

  16. Early Childhood Matters: The Bulletin of the Bernard van Leer Foundation, 1999.

    ERIC Educational Resources Information Center

    Smale, Jim, Ed.

    1999-01-01

    This document consists of the three 1999 issues of The Bernard van Leer Foundation's "Early Childhood Matters." This periodical, addressed to practitioners in the field of early childhood education, evolved from an in-house publication directed to projects funded by the Bernard van Leer Foundation. Articles in the February 1999 edition…

  17. Validity of Dietary Restraint Scales: Reply to van Strien et al. (2006)

    ERIC Educational Resources Information Center

    Stice, Eric; Presnell, Katherine; Lowe, Michael R.; Burton, Emily

    2006-01-01

    In T. van Strien, R. C. M. E. Engels, W. van Staveren, and C. P. Herman's (see record 2006-03905-010) comment, they contested the conclusion that dietary restraint scales are invalid measures of acute dietary restriction (E. Stice, M. Fisher, & M. R. Lowe, 2004). The authors respond to their concerns and conclude that researchers should (a) not…

  18. MATE (Mentale Aspecten van Team Effectiviteit) (MATE (Mental Aspects of Team Effectiveness))

    DTIC Science & Technology

    2008-05-01

    gedachten lezen en elkaars; gedragingen voorspellen. Het kennen van elkaars verantwoordehijkheden, normen , interactiepatronen, kennis, vaardigbeden...Persoonsrollen " Voorkeuren 0 Leiderschap * Normen en waarden 0 Balans sterktes; & zwaktes " Motivatie " Vertrouwen Alle tearngedragingen spelen zicb af binnen...worden gewerkt (wordt gedaan in intro, bivak). Van confronhatiefase naar conforinatiefase Doel: toewerken naar gezamenlijke normen en waarden waarin de

  19. 49 CFR 393.128 - What are the rules for securing automobiles, light trucks and vans?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false What are the rules for securing automobiles, light... automobiles, light trucks and vans? (a) Applicability. The rules in this section apply to the transportation of automobiles, light trucks, and vans which individually weigh 4,536 kg. (10,000 lb) or...

  20. Community Music during the New Deal: The Contributions of Willem Van de Wall and Max Kaplan

    ERIC Educational Resources Information Center

    Krikun, Andrew

    2010-01-01

    Willem Van de Wall (1887-1953) and Max Kaplan (1911-98) built careers spanning music performance, music education, adult education, sociology, social work, music therapy and community music. Willem Van de Wall was a seminal influence on the development of the fields of music therapy and adult education--researching the role of music in…