Sample records for disaggregation license assignment

  1. 47 CFR 27.1333 - Geographic partitioning, spectrum disaggregation, license assignment, and transfer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 700 MHz Public/Private Partnership § 27.1333 Geographic partitioning, spectrum disaggregation, license...

  2. 47 CFR 27.1333 - Geographic partitioning, spectrum disaggregation, license assignment, and transfer.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 700 MHz Public/Private Partnership § 27.1333 Geographic partitioning, spectrum disaggregation, license...

  3. 47 CFR 27.1333 - Geographic partitioning, spectrum disaggregation, license assignment, and transfer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 700 MHz Public/Private Partnership § 27.1333 Geographic partitioning, spectrum disaggregation, license...

  4. 47 CFR 101.1111 - Partitioning and disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1111 Partitioning and disaggregation. (a) Definitions. Disaggregation. The assignment of discrete portions or “blocks” of spectrum licensed to a geographic licensee or qualifying entity. Partitioning. The assignment of geographic portions...

  5. 47 CFR 101.535 - Geographic partitioning and spectrum aggregation/disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.535 Geographic partitioning and spectrum aggregation/disaggregation. (a) Eligibility... grant of a license. (2) Any existing frequency coordination agreements shall convey with the assignment...

  6. 47 CFR 101.535 - Geographic partitioning and spectrum aggregation/disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.535 Geographic partitioning and spectrum aggregation/disaggregation. (a) Eligibility... grant of a license. (2) Any existing frequency coordination agreements shall convey with the assignment...

  7. 47 CFR 101.535 - Geographic partitioning and spectrum aggregation/disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.535 Geographic partitioning and spectrum aggregation/disaggregation. (a) Eligibility... grant of a license. (2) Any existing frequency coordination agreements shall convey with the assignment...

  8. 47 CFR 101.535 - Geographic partitioning and spectrum aggregation/disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.535 Geographic partitioning and spectrum aggregation/disaggregation. (a) Eligibility... grant of a license. (2) Any existing frequency coordination agreements shall convey with the assignment...

  9. 47 CFR 101.535 - Geographic partitioning and spectrum aggregation/disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.535 Geographic partitioning and spectrum aggregation/disaggregation. (a) Eligibility... grant of a license. (2) Any existing frequency coordination agreements shall convey with the assignment...

  10. 47 CFR 90.365 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Partitioned licenses and disaggregated spectrum... § 90.365 Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Party seeking approval... disaggregate their licensed spectrum at any time following the grant of their licenses. Multilateration LMS...

  11. 47 CFR 90.365 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Partitioned licenses and disaggregated spectrum... § 90.365 Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Party seeking approval... disaggregate their licensed spectrum at any time following the grant of their licenses. Multilateration LMS...

  12. 47 CFR 90.365 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Partitioned licenses and disaggregated spectrum... § 90.365 Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Party seeking approval... disaggregate their licensed spectrum at any time following the grant of their licenses. Multilateration LMS...

  13. 47 CFR 90.365 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Partitioned licenses and disaggregated spectrum... § 90.365 Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Party seeking approval... disaggregate their licensed spectrum at any time following the grant of their licenses. Multilateration LMS...

  14. 47 CFR 90.813 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Partitioned licenses and disaggregated spectrum... Specialized Mobile Radio Service § 90.813 Partitioned licenses and disaggregated spectrum. (a) Eligibility.... Spectrum may be disaggregated in any amount. (3) Combined partitioning and disaggregation. The Commission...

  15. 47 CFR 90.813 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Partitioned licenses and disaggregated spectrum... Specialized Mobile Radio Service § 90.813 Partitioned licenses and disaggregated spectrum. (a) Eligibility.... Spectrum may be disaggregated in any amount. (3) Combined partitioning and disaggregation. The Commission...

  16. 47 CFR 90.813 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Partitioned licenses and disaggregated spectrum... Specialized Mobile Radio Service § 90.813 Partitioned licenses and disaggregated spectrum. (a) Eligibility.... Spectrum may be disaggregated in any amount. (3) Combined partitioning and disaggregation. The Commission...

  17. 47 CFR 90.813 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Partitioned licenses and disaggregated spectrum... Specialized Mobile Radio Service § 90.813 Partitioned licenses and disaggregated spectrum. (a) Eligibility.... Spectrum may be disaggregated in any amount. (3) Combined partitioning and disaggregation. The Commission...

  18. 47 CFR 90.911 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Partitioned licenses and disaggregated spectrum. 90.911 Section 90.911 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.911 Partitioned licenses and disaggregated spectrum. (a) Eligibility...

  19. 47 CFR 90.911 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Partitioned licenses and disaggregated spectrum. 90.911 Section 90.911 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.911 Partitioned licenses and disaggregated spectrum. (a) Eligibility...

  20. 47 CFR 90.911 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Partitioned licenses and disaggregated spectrum. 90.911 Section 90.911 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.911 Partitioned licenses and disaggregated spectrum. (a) Eligibility...

  1. 47 CFR 90.911 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Partitioned licenses and disaggregated spectrum. 90.911 Section 90.911 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.911 Partitioned licenses and disaggregated spectrum. (a) Eligibility...

  2. 47 CFR 90.911 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Partitioned licenses and disaggregated spectrum. 90.911 Section 90.911 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Specialized Mobile Radio Service § 90.911 Partitioned licenses and disaggregated spectrum. (a) Eligibility...

  3. 47 CFR 24.714 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Partitioned licenses and disaggregated spectrum... Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Parties seeking approval for... § 24.839. (2) Broadband PCS licensees in spectrum blocks A, B, D, and E and broadband PCS C and F block...

  4. 47 CFR 24.714 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Partitioned licenses and disaggregated spectrum... Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Parties seeking approval for... § 24.839. (2) Broadband PCS licensees in spectrum blocks A, B, D, and E and broadband PCS C and F block...

  5. 47 CFR 24.714 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Partitioned licenses and disaggregated spectrum... Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Parties seeking approval for... § 24.839. (2) Broadband PCS licensees in spectrum blocks A, B, D, and E and broadband PCS C and F block...

  6. 47 CFR 24.714 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Partitioned licenses and disaggregated spectrum... Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Parties seeking approval for... § 24.839. (2) Broadband PCS licensees in spectrum blocks A, B, D, and E and broadband PCS C and F block...

  7. 47 CFR 24.714 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Partitioned licenses and disaggregated spectrum... Partitioned licenses and disaggregated spectrum. (a) Eligibility. (1) Parties seeking approval for... § 24.839. (2) Broadband PCS licensees in spectrum blocks A, B, D, and E and broadband PCS C and F block...

  8. 47 CFR 80.60 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Partitioned licenses and disaggregated spectrum... licenses and disaggregated spectrum. (a) Except as specified in § 20.15(c) of this chapter with respect to... spectrum pursuant to the procedures set forth in this section. (2) AMTS geographic area licensees, see § 80...

  9. 47 CFR 80.60 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Partitioned licenses and disaggregated spectrum... licenses and disaggregated spectrum. (a) Except as specified in § 20.15(c) of this chapter with respect to... spectrum pursuant to the procedures set forth in this section. (2) AMTS geographic area licensees, see § 80...

  10. 47 CFR 80.60 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Partitioned licenses and disaggregated spectrum... licenses and disaggregated spectrum. (a) Except as specified in § 20.15(c) of this chapter with respect to... spectrum pursuant to the procedures set forth in this section. (2) AMTS geographic area licensees, see § 80...

  11. 47 CFR 80.60 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Partitioned licenses and disaggregated spectrum... licenses and disaggregated spectrum. (a) Except as specified in § 20.15(c) of this chapter with respect to... spectrum pursuant to the procedures set forth in this section. (2) AMTS geographic area licensees, see § 80...

  12. 47 CFR 80.60 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Partitioned licenses and disaggregated spectrum... licenses and disaggregated spectrum. (a) Except as specified in § 20.15(c) of this chapter with respect to... spectrum pursuant to the procedures set forth in this section. (2) AMTS geographic area licensees, see § 80...

  13. 47 CFR 27.15 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Geographic partitioning and spectrum... Geographic partitioning and spectrum disaggregation. (a) Eligibility. (1) Parties seeking approval for... service area or disaggregate their licensed spectrum at any time following the grant of their licenses. (b...

  14. 47 CFR 90.813 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... defined by coordinate points at every 3 degrees along the partitioned service area unless an FCC... disaggregation. (c) Installment payments—(1) Apportioning the balance on installment payment plans. When a... partitions its licensed area or disaggregates spectrum to another party, the outstanding balance owed by the...

  15. 47 CFR 90.365 - Partitioned licenses and disaggregated spectrum.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Partitioned licenses and disaggregated spectrum. 90.365 Section 90.365 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Intelligent Transportation Systems Radio Service...

  16. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition their...

  17. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition their...

  18. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition their...

  19. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition their...

  20. 47 CFR 101.1323 - Spectrum aggregation, disaggregation, and partitioning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Spectrum aggregation, disaggregation, and... Requirements § 101.1323 Spectrum aggregation, disaggregation, and partitioning. (a) Eligibility. (1) Parties... aggregate spectrum in any MAS bands, but may not disaggregate their licensed spectrum or partition their...

  1. 47 CFR 95.823 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Geographic partitioning and spectrum... Geographic partitioning and spectrum disaggregation. (a) Eligibility. Parties seeking Commission approval of geographic partitioning or spectrum disaggregation of 218-219 MHz Service system licenses shall request an...

  2. 47 CFR 95.823 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Geographic partitioning and spectrum... Geographic partitioning and spectrum disaggregation. (a) Eligibility. Parties seeking Commission approval of geographic partitioning or spectrum disaggregation of 218-219 MHz Service system licenses shall request an...

  3. 47 CFR 95.823 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Geographic partitioning and spectrum... Geographic partitioning and spectrum disaggregation. (a) Eligibility. Parties seeking Commission approval of geographic partitioning or spectrum disaggregation of 218-219 MHz Service system licenses shall request an...

  4. 47 CFR 95.823 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Geographic partitioning and spectrum... Geographic partitioning and spectrum disaggregation. (a) Eligibility. Parties seeking Commission approval of geographic partitioning or spectrum disaggregation of 218-219 MHz Service system licenses shall request an...

  5. 47 CFR 95.823 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Geographic partitioning and spectrum... Geographic partitioning and spectrum disaggregation. (a) Eligibility. Parties seeking Commission approval of geographic partitioning or spectrum disaggregation of 218-219 MHz Service system licenses shall request an...

  6. 75 FR 38959 - Uniform License Renewal, Discontinuance of Operations, and Geographic Partitioning and Spectrum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... Spectrum Disaggregation Rules and Policies for Certain Wireless Radio Services AGENCY: Federal..., geographic partitioning, and spectrum disaggregation for certain Wireless Radio Services in an effort to... Counsel, Mobility Division, Wireless Telecommunications Bureau, at (202) 418- 0920, or e-mail at Richard...

  7. 47 CFR 27.15 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... license pursuant to § 1.948. (2) AWS and WCS licensees may apply to partition their licensed geographic... following rules apply to WCS and AWS licensees holding authorizations for purposes of implementing the... bands, the following rules apply to WCS and AWS licensees holding authorizations for purposes of...

  8. 47 CFR 101.56 - Partitioned service areas (PSAs) and disaggregated spectrum.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... area will be treated as a separate protected service area. (d)(1) When any area within an EA becomes a...) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers.... (a)(1) The holder of an EA authorization to provide service pursuant to the competitive bidding...

  9. 47 CFR 101.56 - Partitioned service areas (PSAs) and disaggregated spectrum.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... area will be treated as a separate protected service area. (d)(1) When any area within an EA becomes a...) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers.... (a)(1) The holder of an EA authorization to provide service pursuant to the competitive bidding...

  10. 47 CFR 101.56 - Partitioned service areas (PSAs) and disaggregated spectrum.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... area will be treated as a separate protected service area. (d)(1) When any area within an EA becomes a...) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers.... (a)(1) The holder of an EA authorization to provide service pursuant to the competitive bidding...

  11. 47 CFR 101.56 - Partitioned service areas (PSAs) and disaggregated spectrum.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... area will be treated as a separate protected service area. (d)(1) When any area within an EA becomes a...) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers.... (a)(1) The holder of an EA authorization to provide service pursuant to the competitive bidding...

  12. 47 CFR 27.15 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... licensees have agreed to a different signal level. (c) License term. The license term for a partitioned...) Except for WCS licensees holding authorizations for Block A in the 698-704 MHz and 728-734 MHz bands, Block B in the 704-710 MHz and 734-740 MHz bands, Block E in the 722-728 MHz band, Blocks C, C1, or C2...

  13. 47 CFR 24.839 - Transfer of control or assignment of license.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Transfer of control or assignment of license... Broadband PCS § 24.839 Transfer of control or assignment of license. (a) Restrictions on Assignments and Transfers of Licenses for Frequency Blocks C and F won in closed bidding. No assignment or transfer of...

  14. Characteristics of Illinois Public Community College Faculty Based on Their Primary Teaching Assignments.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    Data on the characteristics of full- and part-time faculty at Illinois public community colleges are presented and analyzed in terms of the faculty members' primary teaching assignments for fall 1990. Tables provide statistics on numbers of faculty at each institution disaggregated by gender; age ranges; ethnic/racial classification; employment…

  15. 47 CFR 90.709 - Special limitations on amendment of applications and on assignment or transfer of authorizations...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... as the applicant; (2) Any application to assign or transfer a license for a Phase I, non-nationwide... assign a license for a Phase I nationwide system before the licensee has constructed at least 40 percent... request to amend an application or to transfer or assign a license does not involve a substantial change...

  16. 47 CFR 90.709 - Special limitations on amendment of applications and on assignment or transfer of authorizations...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... as the applicant; (2) Any application to assign or transfer a license for a Phase I, non-nationwide... assign a license for a Phase I nationwide system before the licensee has constructed at least 40 percent... request to amend an application or to transfer or assign a license does not involve a substantial change...

  17. Getting under the hood: how and for whom does increasing course structure work?

    PubMed

    Eddy, Sarah L; Hogan, Kelly A

    2014-01-01

    At the college level, the effectiveness of active-learning interventions is typically measured at the broadest scales: the achievement or retention of all students in a course. Coarse-grained measures like these cannot inform instructors about an intervention's relative effectiveness for the different student populations in their classrooms or about the proximate factors responsible for the observed changes in student achievement. In this study, we disaggregate student data by racial/ethnic groups and first-generation status to identify whether a particular intervention-increased course structure-works better for particular populations of students. We also explore possible factors that may mediate the observed changes in student achievement. We found that a "moderate-structure" intervention increased course performance for all student populations, but worked disproportionately well for black students-halving the black-white achievement gap-and first-generation students-closing the achievement gap with continuing-generation students. We also found that students consistently reported completing the assigned readings more frequently, spending more time studying for class, and feeling an increased sense of community in the moderate-structure course. These changes imply that increased course structure improves student achievement at least partially through increasing student use of distributed learning and creating a more interdependent classroom community. © 2014 S. L. Eddy and K. A. Hogan. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  18. 47 CFR 27.15 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... for licensees holding AWS authorizations in the 1915-1920 MHz and 1995-2000 MHz bands or the 2000-2020... bands, or the 2000-2020 MHz and 2180-2200 MHz bands, the following rules apply for purposes of...) for 2000-2020 MHz and 2180-2200 MHz licenses and those enumerated in § 27.14(r) for 1915-1920 MHz and...

  19. 48 CFR 227.7009 - Patent releases, license agreements, and assignments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Patent releases, license... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7009 Patent releases, license agreements, and...

  20. Pathway Towards Fluency: Using 'disaggregate instruction' to promote science literacy

    NASA Astrophysics Data System (ADS)

    Brown, Bryan A.; Ryoo, Kihyun; Rodriguez, Jamie

    2010-07-01

    This study examines the impact of Disaggregate Instruction on students' science learning. Disaggregate Instruction is the idea that science teaching and learning can be separated into conceptual and discursive components. Using randomly assigned experimental and control groups, 49 fifth-grade students received web-based science lessons on photosynthesis using our experimental approach. We supplemented quantitative statistical comparisons of students' performance on pre- and post-test questions (multiple choice and short answer) with a qualitative analysis of students' post-test interviews. The results revealed that students in the experimental group outscored their control group counterparts across all measures. In addition, students taught using the experimental method demonstrated an improved ability to write using scientific language as well as an improved ability to provide oral explanations using scientific language. This study has important implications for how science educators can prepare teachers to teach diverse student populations.

  1. Alternative licensing arrangements and spectrum economics: The case of multipoint distribution service

    NASA Technical Reports Server (NTRS)

    Agnew, C. E.

    1981-01-01

    At present, the Federal Communications Commission assigns radio licenses following a determination of the public interest. Whenever mutually conflicting license applications are filed, the Commission holds a comparative hearing. This assignment mechanism is criticized as cumbersome and unrealiable, and three alternatives are proposed: increasing the available spectrum, and either auctions or lotteries of radio licenses. An analysis is presented of the present system and these alternative arrangments for assigning rights to the frequency spectrum for the Multipoint Distribution Service (MDS). Although MDS is a relatively minor radio service, it serves as a prototype for message distribution services with a large potential for use in business communications. Moreover, the way in which the initial batch of MDS licenses was assigned provides a unique opportunity for empirical work on the economics of the licensing process.

  2. 47 CFR 27.15 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-2020 MHz and 2180-2200 MHz bands; or the 1695-1710 MHz, 1755-1780 MHz and 2155-2180 MHz bands, the... licensees holding AWS authorizations in the 1915-1920 MHz and 1995-2000 MHz bands, or the 2000-2020 MHz and... enumerated in § 27.14(q) for 2000-2020 MHz and 2180-2200 MHz licenses, those enumerated in § 27.14(r) for...

  3. 47 CFR 78.35 - Assignment or transfer of control.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CABLE TELEVISION RELAY SERVICE Applications and Licenses § 78.35 Assignment or transfer of control. (a) No assignment of the license of a cable television relay station or transfer of control of a CARS... 47 Telecommunication 4 2013-10-01 2013-10-01 false Assignment or transfer of control. 78.35...

  4. 47 CFR 78.35 - Assignment or transfer of control.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CABLE TELEVISION RELAY SERVICE Applications and Licenses § 78.35 Assignment or transfer of control. (a) No assignment of the license of a cable television relay station or transfer of control of a CARS... 47 Telecommunication 4 2014-10-01 2014-10-01 false Assignment or transfer of control. 78.35...

  5. 47 CFR 78.35 - Assignment or transfer of control.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CABLE TELEVISION RELAY SERVICE Applications and Licenses § 78.35 Assignment or transfer of control. (a) No assignment of the license of a cable television relay station or transfer of control of a CARS... 47 Telecommunication 4 2010-10-01 2010-10-01 false Assignment or transfer of control. 78.35...

  6. 47 CFR 78.35 - Assignment or transfer of control.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CABLE TELEVISION RELAY SERVICE Applications and Licenses § 78.35 Assignment or transfer of control. (a) No assignment of the license of a cable television relay station or transfer of control of a CARS... 47 Telecommunication 4 2011-10-01 2011-10-01 false Assignment or transfer of control. 78.35...

  7. 47 CFR 25.119 - Assignment or transfer of control of station authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... assignments and transfers of control of space station licenses to determine whether the initial license was... 47 Telecommunication 2 2012-10-01 2012-10-01 false Assignment or transfer of control of station... Requirements § 25.119 Assignment or transfer of control of station authorization. (a) You must file an...

  8. 47 CFR 25.119 - Assignment or transfer of control of station authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... assignments and transfers of control of space station licenses to determine whether the initial license was... 47 Telecommunication 2 2014-10-01 2014-10-01 false Assignment or transfer of control of station... Requirements § 25.119 Assignment or transfer of control of station authorization. (a) You must file an...

  9. 47 CFR 25.119 - Assignment or transfer of control of station authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... assignments and transfers of control of space station licenses to determine whether the initial license was... 47 Telecommunication 2 2013-10-01 2013-10-01 false Assignment or transfer of control of station... Requirements § 25.119 Assignment or transfer of control of station authorization. (a) You must file an...

  10. 47 CFR 25.119 - Assignment or transfer of control of station authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assignments and transfers of control of space station licenses to determine whether the initial license was... 47 Telecommunication 2 2010-10-01 2010-10-01 false Assignment or transfer of control of station... Requirements § 25.119 Assignment or transfer of control of station authorization. (a) You must file an...

  11. 47 CFR 25.119 - Assignment or transfer of control of station authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... assignments and transfers of control of space station licenses to determine whether the initial license was... 47 Telecommunication 2 2011-10-01 2011-10-01 false Assignment or transfer of control of station... Requirements § 25.119 Assignment or transfer of control of station authorization. (a) You must file an...

  12. 47 CFR 78.35 - Assignment or transfer of control.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Assignment or transfer of control. 78.35... CABLE TELEVISION RELAY SERVICE Applications and Licenses § 78.35 Assignment or transfer of control. (a) No assignment of the license of a cable television relay station or transfer of control of a CARS...

  13. 47 CFR 73.865 - Assignment and transfer of LPFM licenses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... transfer an LPFM construction permit at any time. (e) Transfers of control involving a sudden change of... 47 Telecommunication 4 2012-10-01 2012-10-01 false Assignment and transfer of LPFM licenses. 73... SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.865 Assignment and transfer...

  14. 47 CFR 1.2111 - Assignment or transfer of control: unjust enrichment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for which it is eligible); and (D) A loss of eligibility in year 10 of the license term will result in... 47 Telecommunication 1 2010-10-01 2010-10-01 false Assignment or transfer of control: unjust... assignment (otherwise permitted under the Commission's rules) of a license within three years of receiving a...

  15. 47 CFR 1.2111 - Assignment or transfer of control: unjust enrichment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for which it is eligible); and (D) A loss of eligibility in year 10 of the license term will result in... 47 Telecommunication 1 2011-10-01 2011-10-01 false Assignment or transfer of control: unjust... assignment (otherwise permitted under the Commission's rules) of a license within three years of receiving a...

  16. 48 CFR 227.7009 - Patent releases, license agreements, and assignments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Patent releases, license agreements, and assignments. 227.7009 Section 227.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  17. 48 CFR 227.7009 - Patent releases, license agreements, and assignments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Patent releases, license agreements, and assignments. 227.7009 Section 227.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  18. 48 CFR 227.7009 - Patent releases, license agreements, and assignments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Patent releases, license agreements, and assignments. 227.7009 Section 227.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  19. 48 CFR 227.7009 - Patent releases, license agreements, and assignments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Patent releases, license agreements, and assignments. 227.7009 Section 227.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND...

  20. 48 CFR 252.227-7005 - License term.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government under this license. [56 FR 36479, July 31, 1991, as amended at 66 FR 49861, Oct. 1, 2001] ... patent releases, license agreements, and assignments: License Term (OCT 2001) Alternate I (AUG 1984). The... applications for patent referred to in such “License Grant” clause. Alternate II (OCT 2001). The license hereby...

  1. 48 CFR 252.227-7005 - License term.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Government under this license. [56 FR 36479, July 31, 1991, as amended at 66 FR 49861, Oct. 1, 2001] ... patent releases, license agreements, and assignments: License Term (OCT 2001) Alternate I (AUG 1984). The... applications for patent referred to in such “License Grant” clause. Alternate II (OCT 2001). The license hereby...

  2. 47 CFR 101.55 - Considerations involving transfer or assignment applications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (d) If a proposed transfer of radio facilities is incidental to a sale or other facilities or merger... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers, Modifications, Conditions and Forfeitures § 101.55 Considerations involving transfer or assignment applications. (a) Except...

  3. 47 CFR 101.55 - Considerations involving transfer or assignment applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (d) If a proposed transfer of radio facilities is incidental to a sale or other facilities or merger... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers, Modifications, Conditions and Forfeitures § 101.55 Considerations involving transfer or assignment applications. (a) Except...

  4. 47 CFR 101.55 - Considerations involving transfer or assignment applications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (d) If a proposed transfer of radio facilities is incidental to a sale or other facilities or merger... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers, Modifications, Conditions and Forfeitures § 101.55 Considerations involving transfer or assignment applications. (a) Except...

  5. 47 CFR 101.55 - Considerations involving transfer or assignment applications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (d) If a proposed transfer of radio facilities is incidental to a sale or other facilities or merger... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers, Modifications, Conditions and Forfeitures § 101.55 Considerations involving transfer or assignment applications. (a) Except...

  6. 47 CFR 101.55 - Considerations involving transfer or assignment applications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (d) If a proposed transfer of radio facilities is incidental to a sale or other facilities or merger... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers, Modifications, Conditions and Forfeitures § 101.55 Considerations involving transfer or assignment applications. (a) Except...

  7. 48 CFR 252.227-7007 - License term-running royalty.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false License term-running... of Provisions And Clauses 252.227-7007 License term—running royalty. As prescribed at 227.7009-4(b), insert the following clause in patent releases, license agreements, and assignments: License Term—Running...

  8. 48 CFR 252.227-7007 - License term-running royalty.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License term-running... of Provisions And Clauses 252.227-7007 License term—running royalty. As prescribed at 227.7009-4(b), insert the following clause in patent releases, license agreements, and assignments: License Term—Running...

  9. The Relative Effects and Equity of Inquiry-Based and Commonplace Science Teaching on Students' Knowledge, Reasoning, and Argumentation

    ERIC Educational Resources Information Center

    Wilson, Christopher D.; Taylor, Joseph A.; Kowalski, Susan M.; Carlson, Janet

    2010-01-01

    We conducted a laboratory-based randomized control study to examine the effectiveness of inquiry-based instruction. We also disaggregated the data by student demographic variables to examine if inquiry can provide equitable opportunities to learn. Fifty-eight students aged 14-16 years old were randomly assigned to one of two groups. Both groups of…

  10. 48 CFR 908.7101-7 - Government license tags.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government license tags... Government license tags. (a) Government license tags shall be procured and assignments recorded by DOE... the District of Columbia, official Government tags shall be obtained from the Department of...

  11. 48 CFR 908.7101-7 - Government license tags.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government license tags... ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Special Items 908.7101-7 Government license tags. (a) Government license tags shall be procured and assignments recorded by DOE...

  12. 48 CFR 908.7101-7 - Government license tags.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government license tags... Government license tags. (a) Government license tags shall be procured and assignments recorded by DOE... local laws, regulations, and procedures. (d) In the District of Columbia, official Government tags shall...

  13. 43 CFR 6.54 - Use or manufacture by or for the Government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Use or manufacture by or for the... REGULATIONS Licenses § 6.54 Use or manufacture by or for the Government. A license is not required with respect to the manufacture or use of any invention assigned or required to be assigned without...

  14. 47 CFR 74.532 - Licensing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 74.532 Licensing requirements. (a) An aural broadcast STL or an aural broadcast intercity relay... booster stations. Aural auxiliary stations licensed to low power FM stations will be assigned on a.... (b) More than one aural broadcast STL or intercity relay station may be licensed to a single licensee...

  15. 47 CFR 74.532 - Licensing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... § 74.532 Licensing requirements. (a) An aural broadcast STL or an aural broadcast intercity relay... booster stations. Aural auxiliary stations licensed to low power FM stations will be assigned on a.... (b) More than one aural broadcast STL or intercity relay station may be licensed to a single licensee...

  16. 47 CFR 74.532 - Licensing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... § 74.532 Licensing requirements. (a) An aural broadcast STL or an aural broadcast intercity relay... booster stations. Aural auxiliary stations licensed to low power FM stations will be assigned on a.... (b) More than one aural broadcast STL or intercity relay station may be licensed to a single licensee...

  17. 47 CFR 74.532 - Licensing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 74.532 Licensing requirements. (a) An aural broadcast STL or an aural broadcast intercity relay... booster stations. Aural auxiliary stations licensed to low power FM stations will be assigned on a.... (b) More than one aural broadcast STL or intercity relay station may be licensed to a single licensee...

  18. 47 CFR 74.532 - Licensing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... § 74.532 Licensing requirements. (a) An aural broadcast STL or an aural broadcast intercity relay... booster stations. Aural auxiliary stations licensed to low power FM stations will be assigned on a.... (b) More than one aural broadcast STL or intercity relay station may be licensed to a single licensee...

  19. 48 CFR 252.227-7012 - Patent license and release contract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Patent license and release... of Provisions And Clauses 252.227-7012 Patent license and release contract. As prescribed at 227.7012, insert the following clause in patent releases, license agreements, and assignments: (Contract No...

  20. 48 CFR 252.227-7012 - Patent license and release contract.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Patent license and release... of Provisions And Clauses 252.227-7012 Patent license and release contract. As prescribed at 227.7012, insert the following clause in patent releases, license agreements, and assignments: (Contract No...

  1. 48 CFR 252.227-7012 - Patent license and release contract.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Patent license and release... of Provisions And Clauses 252.227-7012 Patent license and release contract. As prescribed at 227.7012, insert the following clause in patent releases, license agreements, and assignments: (Contract No...

  2. 48 CFR 252.227-7012 - Patent license and release contract.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Patent license and release... of Provisions And Clauses 252.227-7012 Patent license and release contract. As prescribed at 227.7012, insert the following clause in patent releases, license agreements, and assignments: (Contract No...

  3. 48 CFR 252.227-7012 - Patent license and release contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Patent license and release... of Provisions And Clauses 252.227-7012 Patent license and release contract. As prescribed at 227.7012, insert the following clause in patent releases, license agreements, and assignments: (Contract No...

  4. 78 FR 29388 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-047)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: The inventions listed below assigned to the National...

  5. 78 FR 29388 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-052)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  6. 78 FR 29388 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-054)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  7. 78 FR 29387 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-058)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  8. 78 FR 29386 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (13-053)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  9. 78 FR 57664 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-106] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  10. 78 FR 13906 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-015] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  11. 78 FR 13905 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-018] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  12. 78 FR 19744 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-026] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  13. 75 FR 54656 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-109)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  14. 78 FR 13905 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-017] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  15. 78 FR 57663 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-104] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of availability of inventions for licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  16. 78 FR 57664 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-103] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  17. 75 FR 54656 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-107)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of availability of inventions for licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  18. 75 FR 28663 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-057)] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of availability of inventions for licensing. SUMMARY: Patent applications on the inventions listed below assigned...

  19. 78 FR 57665 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-105] Government-Owned Inventions, Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: The inventions listed below assigned to the National...

  20. 78 FR 19743 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ..., Available for Licensing AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Availability of Inventions for Licensing. SUMMARY: Patent applications on the inventions listed below assigned... Continuous Aerodynamic Control Surfaces and Methods for Active Wing Shaping Control; NASA Case No.: ARC-16846...

  1. 48 CFR 227.7010 - Assignments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7010 Assignments. (a) The clause at 252.227-7011 is an example which may be used in contracts of assignment of patent rights to the Government. (b) To facilitate proof of...

  2. Hydro-meteorological evaluation of downscaled global ensemble rainfall forecasts

    NASA Astrophysics Data System (ADS)

    Gaborit, Étienne; Anctil, François; Fortin, Vincent; Pelletier, Geneviève

    2013-04-01

    Ensemble rainfall forecasts are of high interest for decision making, as they provide an explicit and dynamic assessment of the uncertainty in the forecast (Ruiz et al. 2009). However, for hydrological forecasting, their low resolution currently limits their use to large watersheds (Maraun et al. 2010). In order to bridge this gap, various implementations of the statistic-stochastic multi-fractal downscaling technique presented by Perica and Foufoula-Georgiou (1996) were compared, bringing Environment Canada's global ensemble rainfall forecasts from a 100 by 70-km resolution down to 6 by 4-km, while increasing each pixel's rainfall variance and preserving its original mean. For comparison purposes, simpler methods were also implemented such as the bi-linear interpolation, which disaggregates global forecasts without modifying their variance. The downscaled meteorological products were evaluated using different scores and diagrams, from both a meteorological and a hydrological view points. The meteorological evaluation was conducted comparing the forecasted rainfall depths against nine days of observed values taken from Québec City rain gauge database. These 9 days present strong precipitation events occurring during the summer of 2009. For the hydrologic evaluation, the hydrological models SWMM5 and (a modified version of) GR4J were implemented on a small 6 km2 urban catchment located in the Québec City region. Ensemble hydrologic forecasts with a time step of 3 hours were then performed over a 3-months period of the summer of 2010 using the original and downscaled ensemble rainfall forecasts. The most important conclusions of this work are that the overall quality of the forecasts was preserved during the disaggregation procedure and that the disaggregated products using this variance-enhancing method were of similar quality than bi-linear interpolation products. However, variance and dispersion of the different members were, of course, much improved for the variance-enhanced products, compared to the bi-linear interpolation, which is a decisive advantage. The disaggregation technique of Perica and Foufoula-Georgiou (1996) hence represents an interesting way of bridging the gap between the meteorological models' resolution and the high degree of spatial precision sometimes required by hydrological models in their precipitation representation. References Maraun, D., Wetterhall, F., Ireson, A. M., Chandler, R. E., Kendon, E. J., Widmann, M., Brienen, S., Rust, H. W., Sauter, T., Themeßl, M., Venema, V. K. C., Chun, K. P., Goodess, C. M., Jones, R. G., Onof, C., Vrac, M., and Thiele-Eich, I. 2010. Precipitation downscaling under climate change: recent developments to bridge the gap between dynamical models and the end user. Reviews of Geophysics, 48 (3): RG3003, [np]. Doi: 10.1029/2009RG000314. Perica, S., and Foufoula-Georgiou, E. 1996. Model for multiscale disaggregation of spatial rainfall based on coupling meteorological and scaling descriptions. Journal Of Geophysical Research, 101(D21): 26347-26361. Ruiz, J., Saulo, C. and Kalnay, E. 2009. Comparison of Methods Used to Generate Probabilistic Quantitative Precipitation Forecasts over South America. Weather and forecasting, 24: 319-336. DOI: 10.1175/2008WAF2007098.1 This work is distributed under the Creative Commons Attribution 3.0 Unported License together with an author copyright. This license does not conflict with the regulations of the Crown Copyright.

  3. 78 FR 57665 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ...Patent applications on the inventions listed below assigned to the National Aeronautics and Space Administration, have been filed in the United States Patent and Trademark Office, and are available for licensing.

  4. 7 CFR 97.130 - Recording of assignments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PLANT VARIETY AND PROTECTION Assignments and Recording § 97.130 Recording of assignments. (a) Any assignment of an application for a certificate, or of a certificate of plant variety protection, or of any interest in a variety, or any license or grant and conveyance of any right to use of the variety, may be...

  5. 77 FR 49409 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... exclusive license to U.S. Patent Application Serial No. 13/463,442, ``Anti- Obesity Properties of... Federal Government's patent rights in this invention are assigned to the United States of America, as...

  6. Spatial disaggregation of complex soil map units at regional scale based on soil-landscape relationships

    NASA Astrophysics Data System (ADS)

    Vincent, Sébastien; Lemercier, Blandine; Berthier, Lionel; Walter, Christian

    2015-04-01

    Accurate soil information over large extent is essential to manage agronomical and environmental issues. Where it exists, information on soil is often sparse or available at coarser resolution than required. Typically, the spatial distribution of soil at regional scale is represented as a set of polygons defining soil map units (SMU), each one describing several soil types not spatially delineated, and a semantic database describing these objects. Delineation of soil types within SMU, ie spatial disaggregation of SMU allows improved soil information's accuracy using legacy data. The aim of this study was to predict soil types by spatial disaggregation of SMU through a decision tree approach, considering expert knowledge on soil-landscape relationships embedded in soil databases. The DSMART (Disaggregation and Harmonization of Soil Map Units Through resampled Classification Trees) algorithm developed by Odgers et al. (2014) was used. It requires soil information, environmental covariates, and calibration samples, to build then extrapolate decision trees. To assign a soil type to a particular spatial position, a weighed random allocation approach is applied: each soil type in the SMU is weighted according to its assumed proportion of occurrence in the SMU. Thus soil-landscape relationships are not considered in the current version of DSMART. Expert rules on soil distribution considering the relief, parent material and wetlands location were proposed to drive the procedure of allocation of soil type to sampled positions, in order to integrate the soil-landscape relationships. Semantic information about spatial organization of soil types within SMU and exhaustive landscape descriptors were used. In the eastern part of Brittany (NW France), 171 soil types were described; their relative area in the SMU were estimated, geomorphological and geological contexts were recorded. The model predicted 144 soil types. An external validation was performed by comparing predicted with effectively observed soil types derived from available soil maps at scale of 1:25.000 or 1:50.000. Overall accuracies were 63.1% and 36.2%, respectively considering or not the adjacent pixels. The introduction of expert rules based on soil-landscape relationships to allocate soil types to calibration samples enhanced dramatically the results in comparison with a simple weighted random allocation procedure. It also enabled the production of a comprehensive soil map, retrieving expected spatial organization of soils. Estimation of soil properties for various depths is planned using disaggregated soil types, according to the GlobalSoilmap.net specifications. Odgers, N.P., Sun, W., McBratney, A.B., Minasny, B., Clifford, D., 2014. Disaggregating and harmonising soil map units through resampled classification trees. Geoderma 214, 91-100.

  7. 78 FR 1166 - Service Rules for the Advanced Wireless Services in the H Block-Implementing Section 6401 of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... proposals regarding the licensing, use, and assignment of the spectrum, including the costs and benefits of... downlink band. Accordingly, we tentatively conclude that licensing the Upper H Block under flexible use... to our expectation, the record results in a determination that licensing the Upper H Block, the Lower...

  8. Using food intake records to estimate compliance with the Eatwell Plate dietary guidelines.

    PubMed

    Whybrow, S; Macdiarmid, J I; Craig, L C A; Clark, H; McNeill, G

    2016-04-01

    The UK Eatwell Plate is consumer based advice recommending the proportions of five food groups for a balanced diet: starchy foods, fruit and vegetables, dairy foods, nondairy sources of protein and foods and drinks high in fat or sugar. Many foods comprise ingredients from several food groups and consumers need to consider how these fit with the proportions of the Eatwell Plate. This involves disaggregating composite dishes into proportions of individual food components. The present study aimed to match the diets of adults in Scotland to the Eatwell Plate dietary recommendations and to describe the assumptions and methodological issues associated with estimating Eatwell Plate proportions from dietary records. Foods from weighed intake records of 161 females and 151 males were assigned to a single Eatwell group based on the main ingredient for composite foods, and the overall Eatwell Plate proportions of each subject's diet were calculated. Food group proportions were then recalculated after disaggregating composite foods. The fruit and vegetables and starchy food groups consumed were significantly lower than recommended in the Eatwell Plate, whereas the proportions of the protein and foods high in fat or sugar were significantly higher. Failing to disaggregate composite foods gave an inaccurate estimate of the food group composition of the diet. Estimating Eatwell Plate proportions from dietary records is not straightforward, and is reliant on methodological assumptions. These need to be standardised and disseminated to ensure consistent analysis. © 2015 The British Dietetic Association Ltd.

  9. Further analysis of drivers licensed with medical conditions in Utah

    DOT National Transportation Integrated Search

    2001-03-01

    The Utah Driver License Division has implemented a program since 1979 that restricts drivers with medical conditions by functional ability category (medical condition) by assigning them a functional ability level. This study compares the citation, al...

  10. 47 CFR 1.907 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Wireless Radio Services... requests to assign rights granted by the authorization or to transfer control of entities holding authorizations. Auctionable license. A Wireless Radio Service license identified in § 1.2102 of this part for...

  11. 47 CFR 1.907 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Wireless Radio Services Applications and Proceedings Scope and Authority § 1.907 Definitions. Antenna... term also encompasses requests to assign rights granted by the authorization or to transfer control of entities holding authorizations. Auctionable license. A Wireless Radio Service license identified in § 1...

  12. 47 CFR 1.907 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Wireless Radio Services Applications and Proceedings Scope and Authority § 1.907 Definitions. Antenna... term also encompasses requests to assign rights granted by the authorization or to transfer control of entities holding authorizations. Auctionable license. A Wireless Radio Service license identified in § 1...

  13. 47 CFR 73.3500 - Application and report forms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Wireless Telecommunications Bureau Application for Assignments of Authorization and Transfers of Control... Station Construction Permit or License. 315 Application for Consent to Transfer of Control of Corporation... Broadcast Station Construction Permit or License or Transfer of Control of Corporation Holding Broadcast...

  14. 47 CFR 80.33 - Developmental license.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... number of frequencies assignable to a particular station will depend upon the specific requirements of... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE... about the licensing of developmental operations at stations subject to this part. (a) Supplemental...

  15. Spatial weighting approach in numerical method for disaggregation of MDGs indicators

    NASA Astrophysics Data System (ADS)

    Permai, S. D.; Mukhaiyar, U.; Satyaning PP, N. L. P.; Soleh, M.; Aini, Q.

    2018-03-01

    Disaggregation use to separate and classify the data based on certain characteristics or on administrative level. Disaggregated data is very important because some indicators not measured on all characteristics. Detailed disaggregation for development indicators is important to ensure that everyone benefits from development and support better development-related policymaking. This paper aims to explore different methods to disaggregate national employment-to-population ratio indicator to province- and city-level. Numerical approach applied to overcome the problem of disaggregation unavailability by constructing several spatial weight matrices based on the neighbourhood, Euclidean distance and correlation. These methods can potentially be used and further developed to disaggregate development indicators into lower spatial level even by several demographic characteristics.

  16. Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

    PubMed

    Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A; Lundström, Patrik

    2015-01-01

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available.

  17. Fast and Accurate Resonance Assignment of Small-to-Large Proteins by Combining Automated and Manual Approaches

    PubMed Central

    Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A.; Lundström, Patrik

    2015-01-01

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available. PMID:25569628

  18. 47 CFR 1.1104 - Schedule of charges for applications and other filings for media services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Television Services: a. CARS License 327 & 159 270.00 TIC b. CARS Modifications 327 & 159 270.00 TIC c. CARS License Renewal (Electronic Filing) 327 & 159 270.00 TIC d. CARS License Assignment 327 & 159 270.00 TIC e. CARS Transfer of Control 327 & 159 270.00 TIC f. Special Temporary Authority Corres & 159 175.00 TGC g...

  19. 47 CFR 27.1201 - EBS eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS... will serve on the local program committee and demonstrate a recognition of the composition and power of... existing licenses, and their licenses may be renewed, assigned, or transferred, so long as the licensee is...

  20. 47 CFR 27.1201 - EBS eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS... will serve on the local program committee and demonstrate a recognition of the composition and power of... existing licenses, and their licenses may be renewed, assigned, or transferred, so long as the licensee is...

  1. 47 CFR 27.1201 - EBS eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS... will serve on the local program committee and demonstrate a recognition of the composition and power of... existing licenses, and their licenses may be renewed, assigned, or transferred, so long as the licensee is...

  2. 47 CFR 27.1201 - EBS eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS... will serve on the local program committee and demonstrate a recognition of the composition and power of... existing licenses, and their licenses may be renewed, assigned, or transferred, so long as the licensee is...

  3. 47 CFR 27.1201 - EBS eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS... will serve on the local program committee and demonstrate a recognition of the composition and power of... existing licenses, and their licenses may be renewed, assigned, or transferred, so long as the licensee is...

  4. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  5. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  6. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  7. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  8. 41 CFR 109-38.202-3 - Records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Records. 109-38.202-3....202-3 Records. (a) The DPMO assigns “blocks” of U.S. Government license tag numbers to DOE organizations and maintains a current record of such assignments. Additional “blocks” will be assigned upon...

  9. 41 CFR 109-38.202-3 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Records. 109-38.202-3....202-3 Records. (a) The DPMO assigns “blocks” of U.S. Government license tag numbers to DOE organizations and maintains a current record of such assignments. Additional “blocks” will be assigned upon...

  10. 47 CFR 78.18 - Frequency assignments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Frequency assignments. 78.18 Section 78.18... SERVICE Applications and Licenses § 78.18 Frequency assignments. (a) The Cable Television Relay Service is... Relay Service stations operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that...

  11. 47 CFR 78.18 - Frequency assignments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Frequency assignments. 78.18 Section 78.18... SERVICE Applications and Licenses § 78.18 Frequency assignments. (a) The Cable Television Relay Service is... Relay Service stations operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that...

  12. 47 CFR 78.18 - Frequency assignments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Frequency assignments. 78.18 Section 78.18... SERVICE Applications and Licenses § 78.18 Frequency assignments. (a) The Cable Television Relay Service is... Relay Service stations operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that...

  13. 47 CFR 78.18 - Frequency assignments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Frequency assignments. 78.18 Section 78.18... SERVICE Applications and Licenses § 78.18 Frequency assignments. (a) The Cable Television Relay Service is... Relay Service stations operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that...

  14. 47 CFR 78.18 - Frequency assignments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Frequency assignments. 78.18 Section 78.18... SERVICE Applications and Licenses § 78.18 Frequency assignments. (a) The Cable Television Relay Service is... Relay Service stations operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that...

  15. 47 CFR 22.169 - International coordination of channel assignments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false International coordination of channel assignments. 22.169 Section 22.169 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Licensing Requirements and Procedures Applications and...

  16. 76 FR 78620 - Notice of Intent To Grant an Exclusive License; Voltage Networking, LLC; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... fourth line, the word ``non-assignable'' was incorrectly published. This notice corrects that error. FOR... Networking, LLC. Subsequent to the publication of that notice, DoD discovered that the word ``non-assignable...

  17. 47 CFR 73.3573 - Processing FM broadcast station applications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... FM broadcast station applications. (a) Applications for FM broadcast stations are divided into two... community of license or any change in frequency other than to a first-, second-, or third-adjacent channel... frequency or community of license which is not in accord with its current assignment, except for the...

  18. 47 CFR 73.3573 - Processing FM broadcast station applications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FM broadcast station applications. (a) Applications for FM broadcast stations are divided into two... community of license or any change in frequency other than to a first-, second-, or third-adjacent channel... frequency or community of license which is not in accord with its current assignment, except for the...

  19. 47 CFR 73.3573 - Processing FM broadcast station applications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FM broadcast station applications. (a) Applications for FM broadcast stations are divided into two... community of license or any change in frequency other than to a first-, second-, or third-adjacent channel... frequency or community of license which is not in accord with its current assignment, except for the...

  20. Forum Guide to Collecting and Using Disaggregated Data on Racial/Ethnic Subgroups. NFES 2017-017

    ERIC Educational Resources Information Center

    National Forum on Education Statistics, 2016

    2016-01-01

    The National Forum on Education Statistics convened the Data Disaggregation of Racial/Ethnic Subgroups Working Group to identify best practices for disaggregating data on racial/ethnic subgroups. This guide is intended to identify some of the overarching benefits and challenges involved in data disaggregation; recommend appropriate practices for…

  1. 47 CFR 1.994 - Routine terms and conditions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Random Selection Wireless Radio Services Applications and Proceedings Foreign Ownership of Common Carrier... or spectrum leasing arrangement by assignment or transfer of control provided that the subsidiary or... license or spectrum leasing arrangement by assignment or transfer of control provided that the subsidiary...

  2. 47 CFR 1.994 - Routine terms and conditions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Random Selection Wireless Radio Services Applications and Proceedings Foreign Ownership of Common Carrier... or spectrum leasing arrangement by assignment or transfer of control provided that the subsidiary or... license or spectrum leasing arrangement by assignment or transfer of control provided that the subsidiary...

  3. 47 CFR 87.37 - Developmental license.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... understanding. The showing must be signed by the applicant. (c) Assignable frequencies. Developmental stations may be authorized to use frequencies available for the service and class of station proposed. The number of frequencies assigned will depend upon the specific requirements of the developmental program...

  4. 47 CFR 90.609 - Special limitations on amendment of applications for assignment or transfer of authorizations for...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) [Reserved] (b) A license to operate a conventional or trunked radio system may not be assigned or... new system or to an existing licensee that has loaded its system to 70 mobiles per channel and is... combined with an existing SMR system above 800 MHz authorized to operate in the trunked mode by assignment...

  5. 47 CFR 25.113 - Station licenses and launch authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Construction of such stations may commence prior to grant of a license at the applicant's own risk. Applicants... is required by part 17 of this chapter, must include the FCC Antenna Structure Registration Number(s) for the affected structure(s). If no such number has been assigned at the time the application is...

  6. 47 CFR 25.113 - Station licenses and launch authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... is required by part 17 of this chapter, must include the FCC Antenna Structure Registration Number(s) for the affected structure(s). If no such number has been assigned at the time the application is...) Construction permits are not required for U.S.-licensed space stations. Construction of such stations may...

  7. 75 FR 27318 - Notice of Intent To Grant an Exclusive License; FIXMO U.S. INC.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ..., license to practice the following Government-Owned invention as described in U.S. Patent Application Serial No.11/999,050 entitled: ``Method of Tamper Detection for Digital Device,'' which was allowed by... above-mentioned invention is assigned to the United States Government as represented by the National...

  8. 77 FR 43867 - Notice of Intent To Grant Partially Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ...; Phone (281)244-7148; Fax (281) 483-6936. Information about other NASA inventions available for licensing... United States to practice the invention described and claimed in U.S. Patent Nos. 7,295,884 entitled... rights in these inventions have been assigned to the United States of America as represented by the...

  9. Hourly disaggregation of industrial CO2 emissions from Shenzhen, China.

    PubMed

    Ma, Li; Cai, Bofeng; Wu, Feng; Zeng, Hui

    2018-05-01

    Shenzhen's total industrial CO 2 emission was calculated using the IPCC recommended bottom-up approach and data obtained from the China High Resolution Emission Gridded Data (CHRED). Monthly product yield was then used as the proxy to disaggregate a facility's total emission into monthly emissions. Since a thermal power unit's emission changes with daily and hourly power loads, typical power load curves were used as the proxy to disaggregate the monthly emissions on a daily and hourly basis. The daily and hourly emissions of other facilities were calculated according to two specially designed models: the "weekdays + Spring Festival holidays" model for February and the "weekdays + weekends" model for non-February months. The uncertainty ranges associated with the process of the total amount calculation, monthly disaggregation, daily disaggregation and hourly disaggregation were quantitatively estimated. The total combined uncertainty of the hourly disaggregation of "weekdays + weekends" mode was ±26.19%, and that of the "weekdays + Spring Festival holidays" mode was ±33.06%. These temporal-disaggregation methods and uncertainty estimate approaches could also be used for the industrial air pollutant emission inventory and easily reproduced in the whole country. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Multisite rainfall downscaling and disaggregation in a tropical urban area

    NASA Astrophysics Data System (ADS)

    Lu, Y.; Qin, X. S.

    2014-02-01

    A systematic downscaling-disaggregation study was conducted over Singapore Island, with an aim to generate high spatial and temporal resolution rainfall data under future climate-change conditions. The study consisted of two major components. The first part was to perform an inter-comparison of various alternatives of downscaling and disaggregation methods based on observed data. This included (i) single-site generalized linear model (GLM) plus K-nearest neighbor (KNN) (S-G-K) vs. multisite GLM (M-G) for spatial downscaling, (ii) HYETOS vs. KNN for single-site disaggregation, and (iii) KNN vs. MuDRain (Multivariate Rainfall Disaggregation tool) for multisite disaggregation. The results revealed that, for multisite downscaling, M-G performs better than S-G-K in covering the observed data with a lower RMSE value; for single-site disaggregation, KNN could better keep the basic statistics (i.e. standard deviation, lag-1 autocorrelation and probability of wet hour) than HYETOS; for multisite disaggregation, MuDRain outperformed KNN in fitting interstation correlations. In the second part of the study, an integrated downscaling-disaggregation framework based on M-G, KNN, and MuDRain was used to generate hourly rainfall at multiple sites. The results indicated that the downscaled and disaggregated rainfall data based on multiple ensembles from HadCM3 for the period from 1980 to 2010 could well cover the observed mean rainfall amount and extreme data, and also reasonably keep the spatial correlations both at daily and hourly timescales. The framework was also used to project future rainfall conditions under HadCM3 SRES A2 and B2 scenarios. It was indicated that the annual rainfall amount could reduce up to 5% at the end of this century, but the rainfall of wet season and extreme hourly rainfall could notably increase.

  11. 47 CFR 27.4 - Terms and definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... radiocommunication service licensed pursuant to this part for the frequency bands specified in § 27.5(h). Affiliate.... Assigned frequency. The center of the frequency band assigned to a station. Attended operation. Operation... frequencies permitted to be used by a station. This is normally considered to be the necessary or occupied...

  12. Nursing Distance Learning Course Comparison of Assignments and Examination Scores

    ERIC Educational Resources Information Center

    Mundine, Jennifer

    2016-01-01

    Nursing programs have embraced distance learning in their curricula, but discussion is ongoing about course assignments and grading criteria to increase examination scores in nursing distance learning courses. Because course examinations are a predictor of success on the postgraduate licensing examination (NCLEX-RN), the purpose of this study was…

  13. 77 FR 41202 - Notice of Intent to Co-Exclusive License.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ...)(i). NASA hereby gives notice of its intent to grant a co-exclusive license in the United States to... Unsteady Pressure And Flow Rate Distribution In A Fluid Network Version 4, U.S. Patent No. 7,542,885, to... inventions as applicable have been assigned to the United States of America as represented by the...

  14. Creative Commons and Why It Should Be More Commonly Understood

    ERIC Educational Resources Information Center

    Johnson, Doug

    2009-01-01

    Authors, videographers, musicians, photographers, and almost anyone who creates materials and makes them publicly available has an alternative to standard copyright licensing: Creative Commons (CC). It is a tool that helps the creator display a licensing mark. The creator can assign a variety of rights for others to use his work--rights that are…

  15. 47 CFR 22.948 - Partitioning and Disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Partitioning and Disaggregation. 22.948 Section 22.948 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Cellular Radiotelephone Service § 22.948 Partitioning and Disaggregation. (a) Eligibility...

  16. 47 CFR 90.371 - Dedicated short range communications service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Arnold AFB, TN 352250N 0860202W Tyndall AFB, FL 300412N 0853436W Charles E. Kelly Support Facility... new Federal assignment is made, the Commission's Universal Licensing System database will be updated, accordingly, to protect the new Federal assignment and the list in paragraph (b) of this section will be...

  17. 77 FR 71713 - Policies To Promote Rural Radio Service and To Streamline Allotment and Assignment Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ...: Control Number: 3060-0031. Title: Application for Consent to Assignment of Broadcast Station Construction... Station Construction Permit or License, FCC Form 315; Section 73.3580, Local Public Notice of Filing of... construction permits designed primarily to serve Tribal Lands (the ``Tribal Priority''). Tribal affiliated...

  18. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.218 Judges. (a) Assignment. The AA... Administrative Law Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b...

  19. 41 CFR 102-34.180 - What agencies have a special exemption from displaying U.S. Government license plates and motor...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... special exemption from displaying U.S. Government license plates and motor vehicle identification on some... VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.180 What... identification on some of their vehicles? Motor vehicles assigned for the use of the President and the heads of...

  20. 41 CFR 102-34.180 - What agencies have a special exemption from displaying U.S. Government license plates and motor...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... special exemption from displaying U.S. Government license plates and motor vehicle identification on some... VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.180 What... identification on some of their vehicles? Motor vehicles assigned for the use of the President and the heads of...

  1. 41 CFR 102-34.180 - What agencies have a special exemption from displaying U.S. Government license plates and motor...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... special exemption from displaying U.S. Government license plates and motor vehicle identification on some... VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.180 What... identification on some of their vehicles? Motor vehicles assigned for the use of the President and the heads of...

  2. 41 CFR 102-34.180 - What agencies have a special exemption from displaying U.S. Government license plates and motor...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... special exemption from displaying U.S. Government license plates and motor vehicle identification on some... VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.180 What... identification on some of their vehicles? Motor vehicles assigned for the use of the President and the heads of...

  3. 41 CFR 102-34.180 - What agencies have a special exemption from displaying U.S. Government license plates and motor...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... special exemption from displaying U.S. Government license plates and motor vehicle identification on some... VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.180 What... identification on some of their vehicles? Motor vehicles assigned for the use of the President and the heads of...

  4. 47 CFR 25.142 - Licensing provisions for the non-voice, non-geostationary Mobile-Satellite Service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... must identify the power flux density produced at the Earth's surface by each space station of their... § 25.202(f) (1), (2) and (3), as calculated for a fixed point on the Earth's surface in the plane of... transceivers subject to blanket licensing under § 25.115(d)) through the frequency assignment and coordination...

  5. 47 CFR 22.513 - Partitioning and disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Partitioning and disaggregation. 22.513 Section 22.513 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.513 Partitioning and disaggregation. MEA and EA...

  6. 47 CFR 22.513 - Partitioning and disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Partitioning and disaggregation. 22.513 Section 22.513 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.513 Partitioning and disaggregation. MEA and EA...

  7. 47 CFR 22.513 - Partitioning and disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Partitioning and disaggregation. 22.513 Section 22.513 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.513 Partitioning and disaggregation. MEA and EA...

  8. 47 CFR 22.513 - Partitioning and disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Partitioning and disaggregation. 22.513 Section 22.513 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.513 Partitioning and disaggregation. MEA and EA...

  9. 47 CFR 101.56 - Partitioned service areas (PSAs) and disaggregated spectrum.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Partitioned service areas (PSAs) and disaggregated spectrum. 101.56 Section 101.56 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED..., Modifications, Conditions and Forfeitures § 101.56 Partitioned service areas (PSAs) and disaggregated spectrum...

  10. Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects.

    PubMed

    Shi, Xun; Miller, Stephanie; Mwenda, Kevin; Onda, Akikazu; Reese, Judy; Onega, Tracy; Gui, Jiang; Karagas, Margret; Demidenko, Eugene; Moeschler, John

    2013-09-06

    Limited by data availability, most disease maps in the literature are for relatively large and subjectively-defined areal units, which are subject to problems associated with polygon maps. High resolution maps based on objective spatial units are needed to more precisely detect associations between disease and environmental factors. We propose to use a Restricted and Controlled Monte Carlo (RCMC) process to disaggregate polygon-level location data to achieve mapping aggregate data at an approximated individual level. RCMC assigns a random point location to a polygon-level location, in which the randomization is restricted by the polygon and controlled by the background (e.g., population at risk). RCMC allows analytical processes designed for individual data to be applied, and generates high-resolution raster maps. We applied RCMC to the town-level birth defect data for New Hampshire and generated raster maps at the resolution of 100 m. Besides the map of significance of birth defect risk represented by p-value, the output also includes a map of spatial uncertainty and a map of hot spots. RCMC is an effective method to disaggregate aggregate data. An RCMC-based disease mapping maximizes the use of available spatial information, and explicitly estimates the spatial uncertainty resulting from aggregation.

  11. 47 CFR 27.805 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1.4 GHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  12. 47 CFR 27.904 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1670-1675 MHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  13. 47 CFR 27.904 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1670-1675 MHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  14. 47 CFR 27.805 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1.4 GHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  15. 47 CFR 27.805 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1.4 GHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  16. 47 CFR 22.948 - Partitioning and Disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... partition or disaggregate their spectrum to other qualified entities. (2) Partitioning. During the five year... obtaining disaggregated spectrum may only use such spectrum in that portion of the cellular market encompassed by the original licensee's CGSA and may not use such spectrum to provide service to unserved...

  17. 47 CFR 27.805 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1.4 GHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  18. 47 CFR 22.948 - Partitioning and Disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... partition or disaggregate their spectrum to other qualified entities. (2) Partitioning. During the five year... obtaining disaggregated spectrum may only use such spectrum in that portion of the cellular market encompassed by the original licensee's CGSA and may not use such spectrum to provide service to unserved...

  19. 47 CFR 27.904 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1670-1675 MHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  20. 47 CFR 27.904 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1670-1675 MHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  1. 47 CFR 22.948 - Partitioning and Disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... partition or disaggregate their spectrum to other qualified entities. (2) Partitioning. During the five year... obtaining disaggregated spectrum may only use such spectrum in that portion of the cellular market encompassed by the original licensee's CGSA and may not use such spectrum to provide service to unserved...

  2. 47 CFR 22.948 - Partitioning and Disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... partition or disaggregate their spectrum to other qualified entities. (2) Partitioning. During the five year... obtaining disaggregated spectrum may only use such spectrum in that portion of the cellular market encompassed by the original licensee's CGSA and may not use such spectrum to provide service to unserved...

  3. 47 CFR 27.904 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1670-1675 MHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  4. 47 CFR 27.805 - Geographic partitioning and spectrum disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Geographic partitioning and spectrum... partitioning and spectrum disaggregation. An entity that acquires a portion of a 1.4 GHz band licensee's geographic area or spectrum subject to a geographic partitioning or spectrum disaggregation agreement under...

  5. 47 CFR 90.719 - Individual channels available for assignment in the 220-222 MHz band.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the 220-222 MHz band. 90.719 Section 90.719 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Licensing and Use of Frequencies in the 220-222 MHz Band § 90.719 Individual channels available for assignment in the 220-222 MHz band. (a) Channels 171 through 200 are available to both Government and non...

  6. 47 CFR 73.3540 - Application for voluntary assignment or transfer of control.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... control of a corporate licensee or permittee for an FM or TV translator station, a low power TV station and any associated auxiliary station, such as translator microwave relay stations and UHF translator... Licensee or Permittee, or Assignment of License or Permit for an FM or TV translator Station, or a Low...

  7. Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients

    PubMed Central

    DeSantis, Morgan E.; Leung, Eunice H.; Sweeny, Elizabeth A.; Jackrel, Meredith E.; Cushman-Nick, Mimi; Neuhaus-Follini, Alexandra; Vashist, Shilpa; Sochor, Matthew A.; Knight, M. Noelle; Shorter, James

    2012-01-01

    Summary It is not understood how Hsp104, a hexameric AAA+ ATPase from yeast, disaggregates diverse structures including stress-induced aggregates, prions, and α-synuclein conformers connected to Parkinson disease. Here, we establish that Hsp104 hexamers adapt different mechanisms of intersubunit collaboration to disaggregate stress-induced aggregates versus amyloid. To resolve disordered aggregates, Hsp104 subunits collaborate non-co-operatively via probabilistic substrate binding and ATP hydrolysis. To disaggregate amyloid, several subunits co-operatively engage substrate and hydrolyze ATP. Importantly, Hsp104 variants with impaired intersubunit communication dissolve disordered aggregates but not amyloid. Unexpectedly, prokaryotic ClpB subunits collaborate differently than Hsp104 and couple probabilistic substrate binding to cooperative ATP hydrolysis, which enhances disordered aggregate dissolution but sensitizes ClpB to inhibition and diminishes amyloid disaggregation. Finally, we establish that Hsp104 hexamers deploy more subunits to disaggregate Sup35 prion strains with more stable ‘cross-β’ cores. Thus, operational plasticity enables Hsp104 to robustly dissolve amyloid and non-amyloid clients, which impose distinct mechanical demands. PMID:23141537

  8. 47 CFR 90.609 - Special limitations on amendment of applications for assignment or transfer of authorizations for...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... applications for assignment or transfer of authorizations for radio systems above 800 MHz. 90.609 Section 90... PRIVATE LAND MOBILE RADIO SERVICES Regulations Governing Licensing and Use of Frequencies in the 806-824, 851-869, 896-901, and 935-940 MHz Bands Application for Authorizations § 90.609 Special limitations on...

  9. Dynamic Spectrum Management for Military Wireless Networks

    DTIC Science & Technology

    2010-09-01

    auctions, and protocols and etiquettes . Command and control assignments are provided by the regulatory agency by reviewing specific licensing...devices and amateur licensees do not have specific frequency assignments. The Protocols and Etiquettes methods allow these devices to operate within a...with Collision Avoidance (CSMA/CA) a protocol . Etiquettes are rules that are followed without explicit interaction between devices. Simple etiquettes

  10. A Peltier-based freeze-thaw device for meteorite disaggregation

    NASA Astrophysics Data System (ADS)

    Ogliore, R. C.

    2018-02-01

    A Peltier-based freeze-thaw device for the disaggregation of meteorite or other rock samples is described. Meteorite samples are kept in six water-filled cavities inside a thin-walled Al block. This block is held between two Peltier coolers that are automatically cycled between cooling and warming. One cycle takes approximately 20 min. The device can run unattended for months, allowing for ˜10 000 freeze-thaw cycles that will disaggregate meteorites even with relatively low porosity. This device was used to disaggregate ordinary and carbonaceous chondrite regoltih breccia meteorites to search for micrometeoroid impact craters.

  11. 47 CFR 73.7005 - Holding period.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... transferred, etc.). Costs incurred in operating the station are not recoverable (e.g., rent, salaries, utilities, music licensing fees, etc.). Any successive applicants proposing to assign or transfer the...

  12. Disaggregating Qualitative Data from Asian American College Students in Campus Racial Climate Research and Assessment

    ERIC Educational Resources Information Center

    Museus, Samuel D.; Truong, Kimberly A.

    2009-01-01

    This article highlights the utility of disaggregating qualitative research and assessment data on Asian American college students. Given the complexity of and diversity within the Asian American population, scholars have begun to underscore the importance of disaggregating data in the empirical examination of Asian Americans, but most of those…

  13. A statistical approach for isolating fossil fuel emissions in atmospheric inverse problems

    DOE PAGES

    Yadav, Vineet; Michalak, Anna M.; Ray, Jaideep; ...

    2016-10-27

    We study independent verification and quantification of fossil fuel (FF) emissions that constitutes a considerable scientific challenge. By coupling atmospheric observations of CO 2 with models of atmospheric transport, inverse models offer the possibility of overcoming this challenge. However, disaggregating the biospheric and FF flux components of terrestrial fluxes from CO 2 concentration measurements has proven to be difficult, due to observational and modeling limitations. In this study, we propose a statistical inverse modeling scheme for disaggregating winter time fluxes on the basis of their unique error covariances and covariates, where these covariances and covariates are representative of the underlyingmore » processes affecting FF and biospheric fluxes. The application of the method is demonstrated with one synthetic and two real data prototypical inversions by using in situ CO 2 measurements over North America. Also, inversions are performed only for the month of January, as predominance of biospheric CO 2 signal relative to FF CO 2 signal and observational limitations preclude disaggregation of the fluxes in other months. The quality of disaggregation is assessed primarily through examination of a posteriori covariance between disaggregated FF and biospheric fluxes at regional scales. Findings indicate that the proposed method is able to robustly disaggregate fluxes regionally at monthly temporal resolution with a posteriori cross covariance lower than 0.15 µmol m -2 s -1 between FF and biospheric fluxes. Error covariance models and covariates based on temporally varying FF inventory data provide a more robust disaggregation over static proxies (e.g., nightlight intensity and population density). However, the synthetic data case study shows that disaggregation is possible even in absence of detailed temporally varying FF inventory data.« less

  14. Disaggregation induced solvatochromic switch: A study of dansylated polyglycerol dendrons in binary solvent mixture

    NASA Astrophysics Data System (ADS)

    Subuddhi, Usharani; Vuram, Prasanna K.; Chadha, Anju; Mishra, Ashok K.

    2014-07-01

    A reversal in solvatochromic behaviour was observed in second and third generation glycerol based dansylated polyether dendrons in water on addition of a second solvent like methanol or acetonitrile. Below a certain percentage of the nonaqueous solvent there is a negative-solvatochromism observed and above that there is a switch to positive-solvatochromism. The negative-solvatochromism is attributed to the progressive disaggregation of the dendron aggregates by the nonaqueous solvent component. Once the disaggregation process is complete, positive-solvatochromism is exhibited by the dendron monomers. Higher the hydrophobicity of the dendron more is the amount of the second solvent required for disaggregation.

  15. 7 CFR 1735.94 - Final approval and closing procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., permits, licenses, leases, title evidence, corporate proceedings, and contracts to be assigned to the... finance the acquisition, including the submission, in form and substance satisfactory to the Administrator...

  16. Command Disaggregation Attack and Mitigation in Industrial Internet of Things

    PubMed Central

    Zhu, Pei-Dong; Hu, Yi-Fan; Cui, Peng-Shuai; Zhang, Yan

    2017-01-01

    A cyber-physical attack in the industrial Internet of Things can cause severe damage to physical system. In this paper, we focus on the command disaggregation attack, wherein attackers modify disaggregated commands by intruding command aggregators like programmable logic controllers, and then maliciously manipulate the physical process. It is necessary to investigate these attacks, analyze their impact on the physical process, and seek effective detection mechanisms. We depict two different types of command disaggregation attack modes: (1) the command sequence is disordered and (2) disaggregated sub-commands are allocated to wrong actuators. We describe three attack models to implement these modes with going undetected by existing detection methods. A novel and effective framework is provided to detect command disaggregation attacks. The framework utilizes the correlations among two-tier command sequences, including commands from the output of central controller and sub-commands from the input of actuators, to detect attacks before disruptions occur. We have designed components of the framework and explain how to mine and use these correlations to detect attacks. We present two case studies to validate different levels of impact from various attack models and the effectiveness of the detection framework. Finally, we discuss how to enhance the detection framework. PMID:29065461

  17. Command Disaggregation Attack and Mitigation in Industrial Internet of Things.

    PubMed

    Xun, Peng; Zhu, Pei-Dong; Hu, Yi-Fan; Cui, Peng-Shuai; Zhang, Yan

    2017-10-21

    A cyber-physical attack in the industrial Internet of Things can cause severe damage to physical system. In this paper, we focus on the command disaggregation attack, wherein attackers modify disaggregated commands by intruding command aggregators like programmable logic controllers, and then maliciously manipulate the physical process. It is necessary to investigate these attacks, analyze their impact on the physical process, and seek effective detection mechanisms. We depict two different types of command disaggregation attack modes: (1) the command sequence is disordered and (2) disaggregated sub-commands are allocated to wrong actuators. We describe three attack models to implement these modes with going undetected by existing detection methods. A novel and effective framework is provided to detect command disaggregation attacks. The framework utilizes the correlations among two-tier command sequences, including commands from the output of central controller and sub-commands from the input of actuators, to detect attacks before disruptions occur. We have designed components of the framework and explain how to mine and use these correlations to detect attacks. We present two case studies to validate different levels of impact from various attack models and the effectiveness of the detection framework. Finally, we discuss how to enhance the detection framework.

  18. Space Applications of Radioactive Materials

    DOT National Transportation Integrated Search

    1990-06-01

    As the regulatory agency assigned the overall responsibility for ensuring : public safety from hazards associated with U.S. commercial space launch : activities, Office of Commercial Space Transportation (OCST) must oversee that : compliance. License...

  19. 21 CFR 807.35 - Notification of registrant.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... manufacture or process biological products (including devices licensed under section 351 of the Public Health... device activities described in § 807.20, validation of registration and the assignment of a device...

  20. 21 CFR 807.35 - Notification of registrant.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... manufacture or process biological products (including devices licensed under section 351 of the Public Health... device activities described in § 807.20, validation of registration and the assignment of a device...

  1. [Economic impact of informal care after the establishment of the law of dependence in Spain].

    PubMed

    del Pozo Rubio, Raúl; Escribano Sotos, Francisco

    2012-01-01

    The Law of Dependence keeps the informal caregiver´s role, incorporating a specific economic benefit. The aims of this work are 1) to analyze the effect of the Law on informal care existence, and 2) to value the economic impact in the Law, disaggregated by financier. A cross-section study has been conducted from a representative sample of the dependent population in Cuenca (Spain) in February, 2009. We have obtained information for people with level II and III of dependence. A care service delivery simulation is used to quantify the economic impact of informal care to Cuenca (sample), Castilla-La Mancha and Spain. Informal care delivery is assigned in 81,74% of dependency benefits. Total costs of care service delivery is reduced between 36,51% and 80,53% if informal care exits, disaggregated into savings of 122,97-251,04% for user and 23,30-54,47% for public administration. Average estimated copayment for user is 13,25% for real sample, and it rises to 25,77% when it is supposed informal care extinguishes. Informal care is widespread in the Law, and it implies an important household and public resources saving: for household due to the assumption a smaller copayment that theoretical established, which is assumed by Autonomous Communities; in turn, for public administration, because of the fact economic deliveries require fewer resources.

  2. 46 CFR 310.5 - Personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

  3. 46 CFR 310.5 - Personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

  4. 46 CFR 310.5 - Personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

  5. 46 CFR 310.5 - Personnel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... training cruise the Training Ship shall have assigned one or more radio officers holding a valid license... Office of Management and Budget under control number 2133-0010) (Sec. 204(b), Merchant Marine Act, 1936...

  6. Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

    PubMed

    Nillegoda, Nadinath B; Stank, Antonia; Malinverni, Duccio; Alberts, Niels; Szlachcic, Anna; Barducci, Alessandro; De Los Rios, Paolo; Wade, Rebecca C; Bukau, Bernd

    2017-05-15

    Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70. Substrate selection is further tuned by transient complexation between different classes of J-proteins, which expands the range of protein aggregates targeted by metazoan Hsp70 for disaggregation. We assessed the prevalence and evolutionary conservation of J-protein complexation and cooperation in disaggregation. We find the emergence of a eukaryote-specific signature for interclass complexation of canonical J-proteins. Consistently, complexes exist in yeast and human cells, but not in bacteria, and correlate with cooperative action in disaggregation in vitro. Signature alterations exclude some J-proteins from networking, which ensures correct J-protein pairing, functional network integrity and J-protein specialization. This fundamental change in J-protein biology during the prokaryote-to-eukaryote transition allows for increased fine-tuning and broadening of Hsp70 function in eukaryotes.

  7. 78 FR 39704 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... SYNTHESIS OF A MALE-PRODUCED PHEROMONE FOR THE NEOTROPICAL ROOT WEEVIL DIAPREPES ABBREVIATUS (COLEOPTERA... Federal Government's patent rights in this invention are assigned to the United States of America, as...

  8. HIV/AIDS National Strategic Plans of Sub-Saharan African countries: an analysis for gender equality and sex-disaggregated HIV targets

    PubMed Central

    Sherwood, Jennifer; Sharp, Alana; Cooper, Bergen; Roose-Snyder, Beirne; Blumenthal, Susan

    2017-01-01

    Abstract National Strategic Plans (NSPs) for HIV/AIDS are country planning documents that set priorities for programmes and services, including a set of targets to quantify progress toward national and international goals. The inclusion of sex-disaggregated targets and targets to combat gender inequality is important given the high disease burden among young women and adolescent girls in Sub-Saharan Africa, yet no comprehensive gender-focused analysis of NSP targets has been performed. This analysis quantitatively evaluates national HIV targets, included in NSPs from eighteen Sub-Saharan African countries, for sex-disaggregation. Additionally, NSP targets aimed at reducing gender-based inequality in health outcomes are compiled and inductively coded to report common themes. On average, in the eighteen countries included in this analysis, 31% of NSP targets include sex-disaggregation (range 0–92%). Three countries disaggregated a majority (>50%) of their targets by sex. Sex-disaggregation in data reporting was more common for targets related to the early phases of the HIV care continuum: 83% of countries included any sex-disaggregated targets for HIV prevention, 56% for testing and linkage to care, 22% for improving antiretroviral treatment coverage, and 11% for retention in treatment. The most common target to reduce gender inequality was to prevent gender-based violence (present in 50% of countries). Other commonly incorporated target areas related to improving women’s access to family planning, human and legal rights, and decision-making power. The inclusion of sex-disaggregated targets in national planning is vital to ensure that programmes make progress for all population groups. Improving the availability and quality of indicators to measure gender inequality, as well as evaluating programme outcomes by sex, is critical to tracking this progress. This analysis reveals an urgent need to set specific and separate targets for men and women in order to achieve an equitable and effective HIV response and align government planning with international priorities for gender equality. PMID:28973358

  9. The Hidden Academic Opportunity Gaps among Asian Americans and Pacific Islanders: What Disaggregated Data Reveals in Washington State. iCount: A Data Quality Movement for Asian Americans and Pacific Islanders

    ERIC Educational Resources Information Center

    Nguyen, Bach Mai Dolly; Nguyen, Mike Hoa; Teranishi, Robert T.; Hune, Shirley

    2015-01-01

    Utilizing disaggregated data from the Office of the Superintendent of Public Instruction (OSPI) and the Educational Research Data Center (ERDC), this report offers a deeper and more nuanced perspective on the educational realities of Asian Americans and Pacific Islander (AAPI) students and reinforces the need for disaggregated data to unmask the…

  10. Traffic Flow Management Using Aggregate Flow Models and the Development of Disaggregation Methods

    NASA Technical Reports Server (NTRS)

    Sun, Dengfeng; Sridhar, Banavar; Grabbe, Shon

    2010-01-01

    A linear time-varying aggregate traffic flow model can be used to develop Traffic Flow Management (tfm) strategies based on optimization algorithms. However, there are no methods available in the literature to translate these aggregate solutions into actions involving individual aircraft. This paper describes and implements a computationally efficient disaggregation algorithm, which converts an aggregate (flow-based) solution to a flight-specific control action. Numerical results generated by the optimization method and the disaggregation algorithm are presented and illustrated by applying them to generate TFM schedules for a typical day in the U.S. National Airspace System. The results show that the disaggregation algorithm generates control actions for individual flights while keeping the air traffic behavior very close to the optimal solution.

  11. 47 CFR 101.1321 - License transfers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... away only in accordance with the provisions and procedures set forth in § 1.2111 of this chapter. (b... appurtenances may be transferred, assigned, sold, or given away, to any other entity in accordance with the...

  12. 47 CFR 90.621 - Selection and assignment of frequencies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Regulations Governing Licensing and Use of Frequencies in the 806-824, 851-869, 896-901, and 935-940 MHz Bands Policies Governing the Processing of Applications and...

  13. Disaggregating Hot Water Use and Predicting Hot Water Waste in Five Test Homes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Henderson, H.; Wade, J.

    2014-04-01

    While it is important to make the equipment (or 'plant') in a residential hot water system more efficient, the hot water distribution system also affects overall system performance and energy use. Energy wasted in heating water that is not used is estimated to be on the order of 10 to 30 percent of total domestic hot water (DHW) energy use. This field monitoring project installed temperature sensors on the distribution piping (on trunks and near fixtures) and programmed a data logger to collect data at 5 second intervals whenever there was a hot water draw. This data was used tomore » assign hot water draws to specific end uses in the home as well as to determine the portion of each hot water that was deemed useful (i.e., above a temperature threshold at the fixture). Five houses near Syracuse NY were monitored. Overall, the procedures to assign water draws to each end use were able to successfully assign about 50% of the water draws, but these assigned draws accounted for about 95% of the total hot water use in each home. The amount of hot water deemed as useful ranged from low of 75% at one house to a high of 91% in another. At three of the houses, new water heaters and distribution improvements were implemented during the monitoring period and the impact of these improvements on hot water use and delivery efficiency were evaluated.« less

  14. Disaggregating Hot Water Use and Predicting Hot Water Waste in Five Test Homes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Henderson, Hugh; Wade, Jeremy

    2014-04-01

    While it is important to make the equipment (or "plant") in a residential hot water system more efficient, the hot water distribution system also affects overall system performance and energy use. Energy wasted in heating water that is not used is estimated to be on the order of 10%-30% of total domestic hot water (DHW) energy use. This field monitoring project installed temperature sensors on the distribution piping (on trunks and near fixtures) in five houses near Syracuse, NY, and programmed a data logger to collect data at 5 second intervals whenever there was a hot water draw. This datamore » was used to assign hot water draws to specific end uses in the home as well as to determine the portion of each hot water that was deemed useful (i.e., above a temperature threshold at the fixture). Overall, the procedures to assign water draws to each end use were able to successfully assign about 50% of the water draws, but these assigned draws accounted for about 95% of the total hot water use in each home. The amount of hot water deemed as useful ranged from low of 75% at one house to a high of 91% in another. At three of the houses, new water heaters and distribution improvements were implemented during the monitoring period and the impact of these improvements on hot water use and delivery efficiency were evaluated.« less

  15. Temporal rainfall disaggregation using a multiplicative cascade model for spatial application in urban hydrology

    NASA Astrophysics Data System (ADS)

    Müller, H.; Haberlandt, U.

    2018-01-01

    Rainfall time series of high temporal resolution and spatial density are crucial for urban hydrology. The multiplicative random cascade model can be used for temporal rainfall disaggregation of daily data to generate such time series. Here, the uniform splitting approach with a branching number of 3 in the first disaggregation step is applied. To achieve a final resolution of 5 min, subsequent steps after disaggregation are necessary. Three modifications at different disaggregation levels are tested in this investigation (uniform splitting at Δt = 15 min, linear interpolation at Δt = 7.5 min and Δt = 3.75 min). Results are compared both with observations and an often used approach, based on the assumption that a time steps with Δt = 5.625 min, as resulting if a branching number of 2 is applied throughout, can be replaced with Δt = 5 min (called the 1280 min approach). Spatial consistence is implemented in the disaggregated time series using a resampling algorithm. In total, 24 recording stations in Lower Saxony, Northern Germany with a 5 min resolution have been used for the validation of the disaggregation procedure. The urban-hydrological suitability is tested with an artificial combined sewer system of about 170 hectares. The results show that all three variations outperform the 1280 min approach regarding reproduction of wet spell duration, average intensity, fraction of dry intervals and lag-1 autocorrelation. Extreme values with durations of 5 min are also better represented. For durations of 1 h, all approaches show only slight deviations from the observed extremes. The applied resampling algorithm is capable to achieve sufficient spatial consistence. The effects on the urban hydrological simulations are significant. Without spatial consistence, flood volumes of manholes and combined sewer overflow are strongly underestimated. After resampling, results using disaggregated time series as input are in the range of those using observed time series. Best overall performance regarding rainfall statistics are obtained by the method in which the disaggregation process ends at time steps with 7.5 min duration, deriving the 5 min time steps by linear interpolation. With subsequent resampling this method leads to a good representation of manhole flooding and combined sewer overflow volume in terms of hydrological simulations and outperforms the 1280 min approach.

  16. Childhood diarrhoea management practices in Bangladesh: private sector dominance and continued inequities in care.

    PubMed

    Larson, Charles P; Saha, Unnati Rani; Islam, Rafiqul; Roy, Nikhil

    2006-12-01

    Monitoring for disparities in health and services received based upon gender, income, and geography should continue as renewed efforts to reduce under-five mortality are made in response to millennium development goal #4. The purpose of this survey was to provide a nationally representative description of current childhood diarrhoea management practices and disparities in Bangladesh. A nationally representative, cross-sectional, cluster-sample survey was carried out in randomly selected rural and urban populations across Bangladesh. The survey was completed over an 8 month period between November 2003 and June 2004. A total of 7308 children with a prevalent diarrhoeal illness episode within 560 clusters were identified and enrolled in the survey. In 61% of the cases help was sought from a health care provider, with over 90% practicing in the private sector. Caretaker practice disparities favouring males and higher income households were identified. Significant trends (P < 0.001) favouring higher income households were found for having sought help from any provider or a licensed doctor and for treating their child with oral rehydration solution or an antibiotic. Female children in urban households were less likely to be seen by a licensed allopath, adj OR 0.73 (95% CI 0.57, 0.94). Among rural households gender disparities were limited to females being less likely to receive an antibiotic, adj OR 0.74 (95% CI 0.65, 0.86). Households seeking help from a health provider overwhelmingly utilize the private sector in Bangladesh. Gender inequities in the utilization of licensed providers and purchase of antibiotics, favouring males were identified. Findings suggest that higher income, urban households tend to practice greater gender discrimination. In order to better understand health dynamics in urban populations, in particular slum-dwellers, there is a need to disaggregate survey data by household location.

  17. A rank-based approach for correcting systematic biases in spatial disaggregation of coarse-scale climate simulations

    NASA Astrophysics Data System (ADS)

    Nahar, Jannatun; Johnson, Fiona; Sharma, Ashish

    2017-07-01

    Use of General Circulation Model (GCM) precipitation and evapotranspiration sequences for hydrologic modelling can result in unrealistic simulations due to the coarse scales at which GCMs operate and the systematic biases they contain. The Bias Correction Spatial Disaggregation (BCSD) method is a popular statistical downscaling and bias correction method developed to address this issue. The advantage of BCSD is its ability to reduce biases in the distribution of precipitation totals at the GCM scale and then introduce more realistic variability at finer scales than simpler spatial interpolation schemes. Although BCSD corrects biases at the GCM scale before disaggregation; at finer spatial scales biases are re-introduced by the assumptions made in the spatial disaggregation process. Our study focuses on this limitation of BCSD and proposes a rank-based approach that aims to reduce the spatial disaggregation bias especially for both low and high precipitation extremes. BCSD requires the specification of a multiplicative bias correction anomaly field that represents the ratio of the fine scale precipitation to the disaggregated precipitation. It is shown that there is significant temporal variation in the anomalies, which is masked when a mean anomaly field is used. This can be improved by modelling the anomalies in rank-space. Results from the application of the rank-BCSD procedure improve the match between the distributions of observed and downscaled precipitation at the fine scale compared to the original BCSD approach. Further improvements in the distribution are identified when a scaling correction to preserve mass in the disaggregation process is implemented. An assessment of the approach using a single GCM over Australia shows clear advantages especially in the simulation of particularly low and high downscaled precipitation amounts.

  18. Rainfall disaggregation for urban hydrology: Effects of spatial consistence

    NASA Astrophysics Data System (ADS)

    Müller, Hannes; Haberlandt, Uwe

    2015-04-01

    For urban hydrology rainfall time series with a high temporal resolution are crucial. Observed time series of this kind are very short in most cases, so they cannot be used. On the contrary, time series with lower temporal resolution (daily measurements) exist for much longer periods. The objective is to derive time series with a long duration and a high resolution by disaggregating time series of the non-recording stations with information of time series of the recording stations. The multiplicative random cascade model is a well-known disaggregation model for daily time series. For urban hydrology it is often assumed, that a day consists of only 1280 minutes in total as starting point for the disaggregation process. We introduce a new variant for the cascade model, which is functional without this assumption and also outperforms the existing approach regarding time series characteristics like wet and dry spell duration, average intensity, fraction of dry intervals and extreme value representation. However, in both approaches rainfall time series of different stations are disaggregated without consideration of surrounding stations. This yields in unrealistic spatial patterns of rainfall. We apply a simulated annealing algorithm that has been used successfully for hourly values before. Relative diurnal cycles of the disaggregated time series are resampled to reproduce the spatial dependence of rainfall. To describe spatial dependence we use bivariate characteristics like probability of occurrence, continuity ratio and coefficient of correlation. Investigation area is a sewage system in Northern Germany. We show that the algorithm has the capability to improve spatial dependence. The influence of the chosen disaggregation routine and the spatial dependence on overflow occurrences and volumes of the sewage system will be analyzed.

  19. A Genetic Algorithm Approach to Door Assignment in Breakbulk Terminals

    DOT National Transportation Integrated Search

    2001-08-23

    Commercial vehicle regulation and enforcement is a necessary and important function of state governments. Through regulation, states promote highway safety, ensure that motor carriers have the proper licenses and operating permits, and collect taxes ...

  20. 75 FR 68829 - Notice of Intent To Grant Partially Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... Strength Aluminum Alloy for High Temperature Applications, NASA Case No. MFS-31828-1, to Allied Metal... manufacture of aluminum alloy ingots. The patent rights in this invention have been assigned to the United...

  1. 47 CFR 22.107 - General application requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PUBLIC MOBILE SERVICES Licensing Requirements and Procedures Applications and Notifications § 22.107 General application requirements. In general, applications for authorizations, assignments of... 47 Telecommunication 2 2010-10-01 2010-10-01 false General application requirements. 22.107...

  2. K-BREF(Korean BAT reference document) development : BAT and BAT-AELs for large combustion plants and waste incinerators in Korea.

    NASA Astrophysics Data System (ADS)

    Yoo, Heungmin; Lee, Daegyun; Park, Jaehong

    2017-04-01

    Since the initial environmental policy namely "Regulation on assigning license for environmental pollutant emission facilities" was introduced in 1971, the previous environmental policy that assign licenses on emission facilities of each pollutant has been implementing in Korea. From this, economic standard and environmental quality of Korea are recognized as level of developed countries, even though various development activities for industrialization. However, amount of pollutant, emission route and emission source are increasing with development of various industries, and citizens recognition for environment have been changed as well. Thus, ministry of environment of Korea needs systematic policy based on scientific grounds for conversion of paradigm. For this, ministry of environment was introduced new policy namely "integrated pollution prevention and control(IPPC)", and it will be implemented from 2017 in Korea. IPPC is established for considering environment, economic and efficiency: 10 licenses on each pollutant emission will be integrated to one license, and it can be expected simplification for business licensing process. As well, this policy can be upgraded and processed while considering characteristics on location and industry types, in the future. However, to conduct this system harmoniously, policy demanders have to apply integrated control system to their facilities. Especially, the first applied industries by IPPC are two industries, such as large combustion plants for power generation and waste incineration facilities. Therefore, ministry of environment has to publish technical guideline books firstly for those industries, and they were named to "BAT reference document(BREF)". In this study, essential information for BREFs publishment, that is including emission levels, best available technique(BAT) and so on was investigated. In addition, the BAT-associated emission levels (BAT-AELs) of each industry were set using emission data obtained from realtime-monitoring system.

  3. Non-Intrusive Load Monitoring Approaches for Disaggregated Energy Sensing: A Survey

    PubMed Central

    Zoha, Ahmed; Gluhak, Alexander; Imran, Muhammad Ali; Rajasegarar, Sutharshan

    2012-01-01

    Appliance Load Monitoring (ALM) is essential for energy management solutions, allowing them to obtain appliance-specific energy consumption statistics that can further be used to devise load scheduling strategies for optimal energy utilization. Fine-grained energy monitoring can be achieved by deploying smart power outlets on every device of interest; however it incurs extra hardware cost and installation complexity. Non-Intrusive Load Monitoring (NILM) is an attractive method for energy disaggregation, as it can discern devices from the aggregated data acquired from a single point of measurement. This paper provides a comprehensive overview of NILM system and its associated methods and techniques used for disaggregated energy sensing. We review the state-of-the art load signatures and disaggregation algorithms used for appliance recognition and highlight challenges and future research directions. PMID:23223081

  4. Representation of spatial cross correlations in large stochastic seasonal streamflow models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oliveira, G.C.; Kelman, J.; Pereira, M.V.F.

    1988-05-01

    Pereira et al. (1984) presented a special disaggregation procedure for generating cross-correlated monthly flows at many sites while using what are essentially univariate disaggregation models for the flows at each site. This was done by using a nonparametric procedure for constructing residual innovations or noise vectors with cross-correlated components. This note considers the theoretical underpinnings of that streamflow disaggregation procedure and a proposed variation and their ability to reproduce the observed historical cross correlations among concurrent monthly flows at nine Brazilian stations.

  5. HIV/AIDS National Strategic Plans of Sub-Saharan African countries: an analysis for gender equality and sex-disaggregated HIV targets.

    PubMed

    Sherwood, Jennifer; Sharp, Alana; Cooper, Bergen; Roose-Snyder, Beirne; Blumenthal, Susan

    2017-12-01

    National Strategic Plans (NSPs) for HIV/AIDS are country planning documents that set priorities for programmes and services, including a set of targets to quantify progress toward national and international goals. The inclusion of sex-disaggregated targets and targets to combat gender inequality is important given the high disease burden among young women and adolescent girls in Sub-Saharan Africa, yet no comprehensive gender-focused analysis of NSP targets has been performed. This analysis quantitatively evaluates national HIV targets, included in NSPs from eighteen Sub-Saharan African countries, for sex-disaggregation. Additionally, NSP targets aimed at reducing gender-based inequality in health outcomes are compiled and inductively coded to report common themes. On average, in the eighteen countries included in this analysis, 31% of NSP targets include sex-disaggregation (range 0-92%). Three countries disaggregated a majority (>50%) of their targets by sex. Sex-disaggregation in data reporting was more common for targets related to the early phases of the HIV care continuum: 83% of countries included any sex-disaggregated targets for HIV prevention, 56% for testing and linkage to care, 22% for improving antiretroviral treatment coverage, and 11% for retention in treatment. The most common target to reduce gender inequality was to prevent gender-based violence (present in 50% of countries). Other commonly incorporated target areas related to improving women's access to family planning, human and legal rights, and decision-making power. The inclusion of sex-disaggregated targets in national planning is vital to ensure that programmes make progress for all population groups. Improving the availability and quality of indicators to measure gender inequality, as well as evaluating programme outcomes by sex, is critical to tracking this progress. This analysis reveals an urgent need to set specific and separate targets for men and women in order to achieve an equitable and effective HIV response and align government planning with international priorities for gender equality. © The Author 2017. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.

  6. Accuracy evaluation of ClimGen weather generator and daily to hourly disaggregation methods in tropical conditions

    NASA Astrophysics Data System (ADS)

    Safeeq, Mohammad; Fares, Ali

    2011-12-01

    Daily and sub-daily weather data are often required for hydrological and environmental modeling. Various weather generator programs have been used to generate synthetic climate data where observed climate data are limited. In this study, a weather data generator, ClimGen, was evaluated for generating information on daily precipitation, temperature, and wind speed at four tropical watersheds located in Hawai`i, USA. We also evaluated different daily to sub-daily weather data disaggregation methods for precipitation, air temperature, dew point temperature, and wind speed at Mākaha watershed. The hydrologic significance values of the different disaggregation methods were evaluated using Distributed Hydrology Soil Vegetation Model. MuDRain and diurnal method performed well over uniform distribution in disaggregating daily precipitation. However, the diurnal method is more consistent if accurate estimates of hourly precipitation intensities are desired. All of the air temperature disaggregation methods performed reasonably well, but goodness-of-fit statistics were slightly better for sine curve model with 2 h lag. Cosine model performed better than random model in disaggregating daily wind speed. The largest differences in annual water balance were related to wind speed followed by precipitation and dew point temperature. Simulated hourly streamflow, evapotranspiration, and groundwater recharge were less sensitive to the method of disaggregating daily air temperature. ClimGen performed well in generating the minimum and maximum temperature and wind speed. However, for precipitation, it clearly underestimated the number of extreme rainfall events with an intensity of >100 mm/day in all four locations. ClimGen was unable to replicate the distribution of observed precipitation at three locations (Honolulu, Kahului, and Hilo). ClimGen was able to reproduce the distributions of observed minimum temperature at Kahului and wind speed at Kahului and Hilo. Although the weather data generation and disaggregation methods were concentrated in a few Hawaiian watersheds, the results presented can be used to similar mountainous location settings, as well as any specific locations aimed at furthering the site-specific performance evaluation of these tested models.

  7. Welfare generosity and population health among Canadian provinces: a time-series cross-sectional analysis, 1989-2009.

    PubMed

    Ng, Edwin; Muntaner, Carles

    2015-10-01

    Recent work in comparative social epidemiology uses an expenditures approach to examine the link between welfare states and population health. More work is needed that examines the impact of disaggregated expenditures within nations. This study takes advantage of provincial differences within Canada to examine the effects of subnational expenditures and a provincial welfare generosity index on population health. Time-series cross-sectional data are retrieved from the Canadian Socio-Economic Information Management System II Tables for 1989-2009 (10 provinces and 21 years=210 cases). Expenditures are measured using 20 disaggregated indicators, total expenditures and a provincial welfare generosity index, a ombined measure of significant predictors. Health is measured as total, male and female age-standardised mortality rates per 1000 deaths. Estimation techniques include the Prais-Winsten regressions with panel-corrected SEs, a first-order autocorrelation correction model, and fixed-unit effects, adjusted for alternative factors. Analyses reveal that four expenditures effectively reduce mortality rates: medical care, preventive care, other social services and postsecondary education. The provincial welfare generosity index has even larger effects. For an SD increase in the provincial welfare generosity index, total mortality rates are expected to decline by 0.44 SDs. Standardised effects are larger for women (β=-0.57, z(19)=-5.70, p<0.01) than for men (β=-0.38, z(19)=-5.59, p<0.01). Findings show that the expenditures approach can be effectively applied within the context of Canadian provinces, and that targeted spending on health, social services and education has salutary effects. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  8. The professional nurse and regulation.

    PubMed

    Flook, Denise M

    2003-06-01

    The regulation of nursing began as a simple registry process to protect the nursing title and the public. Today, the primary purpose is still the protection of the public through defining nursing practice, approving nursing education, and overseeing the competence of nurses through licensing and disciplinary rules and regulations. State Boards of Nursing are legislatively given the authority to license and discipline the nursing profession. The RN is responsible for the care given to assigned patients. Issues of staffing, delegation, and reporting of incompetent or impaired nurses are a concern of nurses today with regard to their license. Each nurse must understand the regulations, which vary from state to state, that directly and indirectly affect his/her daily practice. As the health care environment is met with several challenges, pressures are increasing to modernize the licensing and competency assessment of nurses. Ultimately, the safety of patients must remain at the center of the regulatory debate.

  9. 47 CFR 78.27 - License conditions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., modifications, assignments or transfers of control, and renewals) in the Cable Television Relay Service to serve cable television systems and other eligible systems, shall contain the condition that cable television... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY...

  10. 47 CFR 78.27 - License conditions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., modifications, assignments or transfers of control, and renewals) in the Cable Television Relay Service to serve cable television systems and other eligible systems, shall contain the condition that cable television... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY...

  11. 47 CFR 78.27 - License conditions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., modifications, assignments or transfers of control, and renewals) in the Cable Television Relay Service to serve cable television systems and other eligible systems, shall contain the condition that cable television... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY...

  12. 47 CFR 78.27 - License conditions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., modifications, assignments or transfers of control, and renewals) in the Cable Television Relay Service to serve cable television systems and other eligible systems, shall contain the condition that cable television... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY...

  13. 47 CFR 78.27 - License conditions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., modifications, assignments or transfers of control, and renewals) in the Cable Television Relay Service to serve cable television systems and other eligible systems, shall contain the condition that cable television... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY...

  14. 47 CFR 1.2003 - Applications affected.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Wireless Telecommunications Bureau Application for Assignment of Authorization and Transfer of Control; FCC... for Consent to Transfer of Control of Corporation Holding Broadcast Station Construction Permit or... License or Transfer of Control of Corporation Holding Radio Broadcast Station Construction Permit or...

  15. 47 CFR 73.3550 - Requests for new or modified call sign assignments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and authorization system accessible through the Internet's World Wide Web by specifying http://www.fcc... propriety is observed and no confusion results with a station for which the FCC issues a license. (m) Where...

  16. Cryptophane Nanoscale Assemblies Expand 129Xe NMR Biosensing.

    PubMed

    Zemerov, Serge D; Roose, Benjamin W; Greenberg, Mara L; Wang, Yanfei; Dmochowski, Ivan J

    2018-06-19

    Cryptophane-based biosensors are promising agents for the ultrasensitive detection of biomedically relevant targets via 129 Xe NMR. Dynamic light scattering revealed that cryptophanes form water-soluble aggregates tens to hundreds of nanometers in size. Acridine orange fluorescence quenching assays allowed quantitation of the aggregation state, with critical concentrations ranging from 200 nM to 600 nM, depending on the cryptophane species in solution. The addition of excess carbonic anhydrase (CA) protein target to a benzenesulfonamide-functionalized cryptophane biosensor (C8B) led to C8B disaggregation and produced the expected 1:1 C8B-CA complex. C8B showed higher affinity at 298 K for the cytoplasmic isozyme CAII than the extracellular CAXII isozyme, which is a biomarker of cancer. Using hyper-CEST NMR, we explored the role of stoichiometry in detecting these two isozymes. Under CA-saturating conditions, we observed that isozyme CAII produces a larger 129 Xe NMR chemical shift change (δ = 5.9 ppm, relative to free biosensor) than CAXII (δ = 2.7 ppm), which indicates the strong potential for isozyme-specific detection. However, stoichiometry-dependent chemical shift data indicated that biosensor disaggregation contributes to the observed 129 Xe NMR chemical shift change that is normally assigned to biosensor-target binding. Finally, we determined that monomeric cryptophane solutions improve hyper-CEST saturation contrast, which enables ultrasensitive detection of biosensor-protein complexes. These insights into cryptophane-solution behavior support further development of xenon biosensors, but will require reinterpretation of the data previously obtained for many water-soluble cryptophanes.

  17. SMAP Soil Moisture Disaggregation using Land Surface Temperature and Vegetation Data

    NASA Astrophysics Data System (ADS)

    Fang, B.; Lakshmi, V.

    2016-12-01

    Soil moisture (SM) is a key parameter in agriculture, hydrology and ecology studies. The global SM retrievals have been providing by microwave remote sensing technology since late 1970s and many SM retrieval algorithms have been developed, calibrated and applied on satellite sensors such as AMSR-E (Advanced Microwave Scanning Radiometer for the Earth Observing System), AMSR-2 (Advanced Microwave Scanning Radiometer 2) and SMOS (Soil Moisture and Ocean Salinity). Particularly, SMAP (Soil Moisture Active/Passive) satellite, which was developed by NASA, was launched in January 2015. SMAP provides soil moisture products of 9 km and 36 km spatial resolutions which are not capable for research and applications of finer scale. Toward this issue, this study applied a SM disaggregation algorithm to disaggregate SMAP passive microwave soil moisture 36 km product. This algorithm was developed based on the thermal inertial relationship between daily surface temperature variation and daily average soil moisture which is modulated by vegetation condition, by using remote sensing retrievals from AVHRR (Advanced Very High Resolution Radiometer, MODIS (Moderate Resolution Imaging Spectroradiometer), SPOT (Satellite Pour l'Observation de la Terre), as well as Land Surface Model (LSM) output from NLDAS (North American Land Data Assimilation System). The disaggregation model was built at 1/8o spatial resolution on monthly basis and was implemented to calculate and disaggregate SMAP 36 km SM retrievals to 1 km resolution in Oklahoma. The SM disaggregation results were also validated using MESONET (Mesoscale Network) and MICRONET (Microscale Network) ground SM measurements.

  18. Load Disaggregation Technologies: Real World and Laboratory Performance

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mayhorn, Ebony T.; Sullivan, Greg P.; Petersen, Joseph M.

    Low cost interval metering and communication technology improvements over the past ten years have enabled the maturity of load disaggregation (or non-intrusive load monitoring) technologies to better estimate and report energy consumption of individual end-use loads. With the appropriate performance characteristics, these technologies have the potential to enable many utility and customer facing applications such as billing transparency, itemized demand and energy consumption, appliance diagnostics, commissioning, energy efficiency savings verification, load shape research, and demand response measurement. However, there has been much skepticism concerning the ability of load disaggregation products to accurately identify and estimate energy consumption of end-uses; whichmore » has hindered wide-spread market adoption. A contributing factor is that common test methods and metrics are not available to evaluate performance without having to perform large scale field demonstrations and pilots, which can be costly when developing such products. Without common and cost-effective methods of evaluation, more developed disaggregation technologies will continue to be slow to market and potential users will remain uncertain about their capabilities. This paper reviews recent field studies and laboratory tests of disaggregation technologies. Several factors are identified that are important to consider in test protocols, so that the results reflect real world performance. Potential metrics are examined to highlight their effectiveness in quantifying disaggregation performance. This analysis is then used to suggest performance metrics that are meaningful and of value to potential users and that will enable researchers/developers to identify beneficial ways to improve their technologies.« less

  19. [The helpers' stress: Effectiveness of a web-based intervention for professionals working with trauma survivors in reducing job burnout and improving work engagement].

    PubMed

    Rogala, Anna; Smoktunowicz, Ewelina; Żukowska, Katarzyna; Kowalska, Martyna; Cieślak, Roman

    The study aimed at evaluating effectiveness of the web-based intervention, "The Helpers' Stress," in reducing job burnout and enhancing work engagement among professionals working with trauma survivors. Participants were randomly allocated to 1 of the 3 intervention modules: 1 - the self-efficacy enhancement (N = 87), 2 - the social support enhancement (N = 85), or to 3 - the educational module (comparison group, N = 81). Participants completed the online questionnaires before the intervention (T1), immediately after (T2), and 4 weeks after the intervention (T3). Due to high drop-out rate at T2 and T3 in social support enhancement module, we excluded from analysis participants assigned to this condition. Participants assigned to the self-efficacy enhancement module presented higher levels of self-efficacy (at T2 and T3), compared to those assigned to the educational module. Job burnout decreased significantly between T1 and T2, and between T2 and T3, and work engagement increased significantly between T1 and T2, and between T1 and T3, among participants assigned to both modules mentioned above. Self-efficacy (T2) mediated the relationship between the group assignment (educational module vs. self-efficacy enhancement module) and respectively job burnout (T3) or work engagement (T3). The results of our study highlight the role of self-efficacy in reducing job burnout and increasing work engagement. Med Pr 2016;67(2):223-237. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  20. 47 CFR 1.1703 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Cable Operations and Licensing... requests to assign rights granted by the authorization or to transfer control of entities holding... specified period, a station in the Cable Television Relay Service. In addition, this term includes authority...

  1. 75 FR 75676 - Smart Garments v. Worldlink Logix Services, Inc.; Notice of Filing of Complaint and Assignment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... Respondent WLLS is a ``freight forwarder/common carrier'' incorporated in New York and licensed by the Commission. Complainant states that it engaged Respondent as ``a shipping agency'' to ship two containers...

  2. 77 FR 68784 - Prospective Grant of Exclusive License: Multiple-Valent Opsonophagocytic Assay Selection Panel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... in the patent referred to below to Flow Applications, Inc., having a place of business in Okawville, Illinois. The patent rights in these inventions have been assigned to the government of the United States...

  3. Nuclear Regulatory Commission activities to prepare for reviewing license applications and issuing licenses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Uleck, R.B.; DeFino, C.V.

    1991-12-31

    The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) assigned States the responsibility to provide for disposal of commercial low-level radioactive waste (LLRW) by 1993. The LLRWPAA also required the US Nuclear Regulatory Commission (NRC) to establish procedures and develop the technical review capability to process license applications for new LLRW disposal facilities. Under the LLRWPAA, NRC is required, to the extent practicable, to complete its review of an LLRW disposal facility license application within 15 months of its submittal by a State. This provision of the LLRWPAA helps ensure that NRC, in addition to protecting public health andmore » safety and the environment, facilitates States` achievement of LLRWPAA milestones for new facility development. A timely NRC review is needed for States to accomplish their objective of having new disposal facilities in operation on the dates prescribed in the LLRWPAA. To help assure NRC and States` compliance with the provisions of the LLRWPAA, NRC has developed a licensing review strategy that includes: (1) the further development of regulatory guidance, (2) enhancement of licensing review capability, and (3) prelicensing regulatory consultation with potential applicants.« less

  4. A rainfall disaggregation scheme for sub-hourly time scales: Coupling a Bartlett-Lewis based model with adjusting procedures

    NASA Astrophysics Data System (ADS)

    Kossieris, Panagiotis; Makropoulos, Christos; Onof, Christian; Koutsoyiannis, Demetris

    2018-01-01

    Many hydrological applications, such as flood studies, require the use of long rainfall data at fine time scales varying from daily down to 1 min time step. However, in the real world there is limited availability of data at sub-hourly scales. To cope with this issue, stochastic disaggregation techniques are typically employed to produce possible, statistically consistent, rainfall events that aggregate up to the field data collected at coarser scales. A methodology for the stochastic disaggregation of rainfall at fine time scales was recently introduced, combining the Bartlett-Lewis process to generate rainfall events along with adjusting procedures to modify the lower-level variables (i.e., hourly) so as to be consistent with the higher-level one (i.e., daily). In the present paper, we extend the aforementioned scheme, initially designed and tested for the disaggregation of daily rainfall into hourly depths, for any sub-hourly time scale. In addition, we take advantage of the recent developments in Poisson-cluster processes incorporating in the methodology a Bartlett-Lewis model variant that introduces dependence between cell intensity and duration in order to capture the variability of rainfall at sub-hourly time scales. The disaggregation scheme is implemented in an R package, named HyetosMinute, to support disaggregation from daily down to 1-min time scale. The applicability of the methodology was assessed on a 5-min rainfall records collected in Bochum, Germany, comparing the performance of the above mentioned model variant against the original Bartlett-Lewis process (non-random with 5 parameters). The analysis shows that the disaggregation process reproduces adequately the most important statistical characteristics of rainfall at wide range of time scales, while the introduction of the model with dependent intensity-duration results in a better performance in terms of skewness, rainfall extremes and dry proportions.

  5. 50 CFR Table 31 to Part 679 - List of Amendment 80 Vessels and LLP Licenses Originally Assigned to an Amendment 80 Vessel

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 31 Table 31 to Part...

  6. 47 CFR 1.2203 - Competitive bidding mechanisms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Random Selection Competitive Bidding Proceedings Broadcast Television Spectrum Reverse Auction § 1.2203... forward auction assigning new spectrum licenses will occur. (2) Reserve price. Reserve prices, either... winning bid. A winning bidder will relinquish spectrum usage rights pursuant to the terms of any winning...

  7. 77 FR 10524 - Information Collections Being Reviewed by the Federal Communications Commission Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... or Permittee, or Assignment of License or Permit, for an FM or TV Translator Station, or a Low Power... permittee for an FM or TV translator station, or low power TV station. This collection also includes the...

  8. Stimulation of Cysteine-Coated CdSe/ZnS Quantum Dot Luminescence by meso-Tetrakis (p-sulfonato-phenyl) Porphyrin

    NASA Astrophysics Data System (ADS)

    Parra, Gustavo G.; Ferreira, Lucimara P.; Gonçalves, Pablo J.; Sizova, Svetlana V.; Oleinikov, Vladimir A.; Morozov, Vladimir N.; Kuzmin, Vladimir A.; Borissevitch, Iouri E.

    2018-02-01

    Interaction between porphyrins and quantum dots (QD) via energy and/or charge transfer is usually accompanied by reduction of the QD luminescence intensity and lifetime. However, for CdSe/ZnS-Cys QD water solutions, kept at 276 K during 3 months (aged QD), the significant increase in the luminescence intensity at the addition of meso-tetrakis (p-sulfonato-phenyl) porphyrin (TPPS4) has been observed in this study. Aggregation of QD during the storage provokes reduction in the quantum yield and lifetime of their luminescence. Using steady-state and time-resolved fluorescence techniques, we demonstrated that TPPS4 stimulated disaggregation of aged CdSe/ZnS-Cys QD in aqueous solutions, increasing the quantum yield of their luminescence, which finally reached that of the fresh-prepared QD. Disaggregation takes place due to increase in electrostatic repulsion between QD at their binding with negatively charged porphyrin molecules. Binding of just four porphyrin molecules per single QD was sufficient for total QD disaggregation. The analysis of QD luminescence decay curves demonstrated that disaggregation stronger affected the luminescence related with the electron-hole annihilation in the QD shell. The obtained results demonstrate the way to repair aged QD by adding of some molecules or ions to the solutions, stimulating QD disaggregation and restoring their luminescence characteristics, which could be important for QD biomedical applications, such as bioimaging and fluorescence diagnostics. On the other hand, the disaggregation is important for QD applications in biology and medicine since it reduces the size of the particles facilitating their internalization into living cells across the cell membrane.

  9. Scientist Spotlight Homework Assignments Shift Students' Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class.

    PubMed

    Schinske, Jeffrey N; Perkins, Heather; Snyder, Amanda; Wyer, Mary

    2016-01-01

    Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments ("Scientist Spotlights") that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. © 2016 J. N. Schinske et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  10. 47 CFR 101.1111 - Partitioning and disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Partitioning and disaggregation. 101.1111 Section 101.1111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1111 Partitioning and...

  11. 47 CFR 101.1111 - Partitioning and disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Partitioning and disaggregation. 101.1111 Section 101.1111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1111 Partitioning and...

  12. 47 CFR 101.1111 - Partitioning and disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Partitioning and disaggregation. 101.1111 Section 101.1111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1111 Partitioning and...

  13. 47 CFR 101.1111 - Partitioning and disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Partitioning and disaggregation. 101.1111 Section 101.1111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Competitive Bidding Procedures for LMDS § 101.1111 Partitioning and...

  14. Multivariate exploration of non-intrusive load monitoring via spatiotemporal pattern network

    DOE PAGES

    Liu, Chao; Akintayo, Adedotun; Jiang, Zhanhong; ...

    2017-12-18

    Non-intrusive load monitoring (NILM) of electrical demand for the purpose of identifying load components has thus far mostly been studied using univariate data, e.g., using only whole building electricity consumption time series to identify a certain type of end-use such as lighting load. However, using additional variables in the form of multivariate time series data may provide more information in terms of extracting distinguishable features in the context of energy disaggregation. In this work, a novel probabilistic graphical modeling approach, namely the spatiotemporal pattern network (STPN) is proposed for energy disaggregation using multivariate time-series data. The STPN framework is shownmore » to be capable of handling diverse types of multivariate time-series to improve the energy disaggregation performance. The technique outperforms the state of the art factorial hidden Markov models (FHMM) and combinatorial optimization (CO) techniques in multiple real-life test cases. Furthermore, based on two homes' aggregate electric consumption data, a similarity metric is defined for the energy disaggregation of one home using a trained model based on the other home (i.e., out-of-sample case). The proposed similarity metric allows us to enhance scalability via learning supervised models for a few homes and deploying such models to many other similar but unmodeled homes with significantly high disaggregation accuracy.« less

  15. Primary midgut, salivary gland, and ovary cultures from Boophilus microplus.

    PubMed

    Mosqueda, Juan; Cossío-Bayugar, Raquel; Rodríguez, Elba; Falcón, Alfonso; Ramos, Alberto; Figueroa, Julio V; Alvarez, Antonio

    2008-12-01

    Primary cell cultures from different tick organs are a valuable tool for host parasite research in the study of the protozoan Babesia sp., which infects different organs of the tick. In this work we describe the generation of midgut, salivary gland, and ovary primary cell cultures from dissections of Boophilus microplus. Midguts, salivary glands, and ovaries were dissected from B. microplus ticks on different days after bovine infestation; different enzymatic disaggregating protocols were tested in the presence of proteolytic enzymes, such as trypsin and collagenase type I and II, for tissue disaggregation and primary cell culture generation. The dissected tick organs obtained 18-20 days after bovine infestation showed a major cellular differentiation and were easier to identify by cellular morphology. The enzymatic disaggregation results showed that each tissue required a different proteolytic enzyme for optimal disaggregation; collagenase type I produced the most complete disaggregation for ovaries but not for midgut or salivary glands. Collagenase type II was effective for salivary glands but performed poorly on ovaries and midgets, and typsin was effective for midguts only. The midgut and ovary primary cell cultures were maintained for 4 weeks in optimal conditions after the cells were no longer viable. The salivary gland cell cultures were viable for 8 months.

  16. Crucial HSP70 co–chaperone complex unlocks metazoan protein disaggregation

    PubMed Central

    Nillegoda, Nadinath B.; Kirstein, Janine; Szlachcic, Anna; Berynskyy, Mykhaylo; Stank, Antonia; Stengel, Florian; Arnsburg, Kristin; Gao, Xuechao; Scior, Annika; Aebersold, Ruedi; Guilbride, D. Lys; Wade, Rebecca C.; Morimoto, Richard I.; Mayer, Matthias P.; Bukau, Bernd

    2016-01-01

    Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states1,2. Healthy metazoan cells effectively eliminate intracellular protein aggregates3,4, indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazoans lack the key heat-shock protein disaggregase HSP100 of non-metazoan HSP70-dependent protein disaggregation systems5,6, and the human HSP70 system alone, even with the crucial HSP110 nucleotide exchange factor, has poor disaggregation activity in vitro4,7. This unresolved conundrum is central to protein quality control biology. Here we show that synergic cooperation between complexed J-protein co-chaperones of classes A and B unleashes highly efficient protein disaggregation activity in human and nematode HSP70 systems. Metazoan mixed-class J-protein complexes are transient, involve complementary charged regions conserved in the J-domains and carboxy-terminal domains of each J-protein class, and are flexible with respect to subunit composition. Complex formation allows J-proteins to initiate transient higher order chaperone structures involving HSP70 and interacting nucleotide exchange factors. A network of cooperative class A and B J-protein interactions therefore provides the metazoan HSP70 machinery with powerful, flexible, and finely regulatable disaggregase activity and a further level of regulation crucial for cellular protein quality control. PMID:26245380

  17. An economic analysis of disaggregation of space assets: Application to GPS

    NASA Astrophysics Data System (ADS)

    Hastings, Daniel E.; La Tour, Paul A.

    2017-05-01

    New ideas, technologies and architectural concepts are emerging with the potential to reshape the space enterprise. One of those new architectural concepts is the idea that rather than aggregating payloads onto large very high performance buses, space architectures should be disaggregated with smaller numbers of payloads (as small as one) per bus and the space capabilities spread across a correspondingly larger number of systems. The primary rationale is increased survivability and resilience. The concept of disaggregation is examined from an acquisition cost perspective. A mixed system dynamics and trade space exploration model is developed to look at long-term trends in the space acquisition business. The model is used to examine the question of how different disaggregated GPS architectures compare in cost to the well-known current GPS architecture. A generation-over-generation examination of policy choices is made possible through the application of soft systems modeling of experience and learning effects. The assumptions that are allowed to vary are: design lives, production quantities, non-recurring engineering and time between generations. The model shows that there is always a premium in the first generation to be paid to disaggregate the GPS payloads. However, it is possible to construct survivable architectures where the premium after two generations is relatively low.

  18. Multivariate exploration of non-intrusive load monitoring via spatiotemporal pattern network

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Chao; Akintayo, Adedotun; Jiang, Zhanhong

    Non-intrusive load monitoring (NILM) of electrical demand for the purpose of identifying load components has thus far mostly been studied using univariate data, e.g., using only whole building electricity consumption time series to identify a certain type of end-use such as lighting load. However, using additional variables in the form of multivariate time series data may provide more information in terms of extracting distinguishable features in the context of energy disaggregation. In this work, a novel probabilistic graphical modeling approach, namely the spatiotemporal pattern network (STPN) is proposed for energy disaggregation using multivariate time-series data. The STPN framework is shownmore » to be capable of handling diverse types of multivariate time-series to improve the energy disaggregation performance. The technique outperforms the state of the art factorial hidden Markov models (FHMM) and combinatorial optimization (CO) techniques in multiple real-life test cases. Furthermore, based on two homes' aggregate electric consumption data, a similarity metric is defined for the energy disaggregation of one home using a trained model based on the other home (i.e., out-of-sample case). The proposed similarity metric allows us to enhance scalability via learning supervised models for a few homes and deploying such models to many other similar but unmodeled homes with significantly high disaggregation accuracy.« less

  19. Shifting senses in lexical semantic development

    PubMed Central

    Rabagliati, Hugh; Marcus, Gary F.; Pylkkänen, Liina

    2010-01-01

    Most words are associated with multiple senses. A DVD can be round (when describing a disc), and a DVD can be an hour long (when describing a movie), and in each case DVD means something different. The possible senses of a word are often predictable, and also constrained, as words cannot take just any meaning: for example, although a movie can be an hour long, it cannot sensibly be described as round (unlike a DVD). Learning the scope and limits of word meaning is vital for the comprehension of natural language, but poses a potentially difficult learnability problem for children. By testing what senses children are willing to assign to a variety of words, we demonstrate that, in comprehension, the problem is solved using a productive learning strategy. Children are perfectly capable of assigning different senses to a word; indeed they are essentially adult-like at assigning licensed meanings. But difficulties arise in determining which senses are assignable: children systematically overestimate the possible senses of a word, allowing meanings that adults rule unlicensed (e.g., taking round movie to refer to a disc). By contrast, this strategy does not extend to production, in which children use licensed, but not unlicensed, senses. Children’s productive comprehension strategy suggests an early emerging facility for using context in sense resolution (a difficult task for natural language processing algorithms), but leaves an intriguing question as to the mechanisms children use to learn a restricted, adult-like set of senses. PMID:20638655

  20. 47 CFR 74.1236 - Emission and bandwidth.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1236 Emission and bandwidth. (a) The license of a station...) apply. (b) Standard width FM channels will be assigned and the transmitting apparatus shall be operated...

  1. 47 CFR 1.2207 - Two competing participants required.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... by Random Selection Competitive Bidding Proceedings Broadcast Television Spectrum Reverse Auction § 1... to relinquish spectrum usage rights in exchange for a share of the proceeds from the related forward auction assigning new spectrum licenses unless at least two competing licensees participate in the reverse...

  2. Origin destination disaggregation using fratar biproportional least squares estimation for truck forecasting.

    DOT National Transportation Integrated Search

    2009-02-01

    This working paper describes a group of techniques for disaggregating origin-destination tables : for truck forecasting that makes explicit use of observed traffic on a network. Six models within : the group are presented, each of which uses nonlinea...

  3. 78 FR 50425 - Prospective Grant of Exclusive License: Development of Brachyury Tumor Associated Antigens as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ...This is notice, in accordance with 35 U.S.C. 209 and 37 CFR Part 404, that the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive patent license to practice the inventions embodied in the following U.S. Patents and Patent Applications to Bavarian Nordic Immunotherapeutics (``BNIT'') located in Mountain View, CA, USA. Intellectual Property: U.S. Provisional Patent Application No. 61/ 701,528 [HHS Ref. No. E-054-2011/0-US-01] filed September 17, 2012, entitled ``Methods and Compositions for the Treatment of Cancer,'' as well as all international applications, continuation applications and divisional applications. The patent rights in these inventions have been assigned to the government of the United States of America. The prospective exclusive license territory may be worldwide and the field of use will be limited to the use of Licensed Patent Rights for development of pox virus-based immunotherapeutics for colorectal cancer.

  4. From Sub-basin to Grid Scale Soil Moisture Disaggregation in SMART, A Semi-distributed Hydrologic Modeling Framework

    NASA Astrophysics Data System (ADS)

    Ajami, H.; Sharma, A.

    2016-12-01

    A computationally efficient, semi-distributed hydrologic modeling framework is developed to simulate water balance at a catchment scale. The Soil Moisture and Runoff simulation Toolkit (SMART) is based upon the delineation of contiguous and topologically connected Hydrologic Response Units (HRUs). In SMART, HRUs are delineated using thresholds obtained from topographic and geomorphic analysis of a catchment, and simulation elements are distributed cross sections or equivalent cross sections (ECS) delineated in first order sub-basins. ECSs are formulated by aggregating topographic and physiographic properties of the part or entire first order sub-basins to further reduce computational time in SMART. Previous investigations using SMART have shown that temporal dynamics of soil moisture are well captured at a HRU level using the ECS delineation approach. However, spatial variability of soil moisture within a given HRU is ignored. Here, we examined a number of disaggregation schemes for soil moisture distribution in each HRU. The disaggregation schemes are either based on topographic based indices or a covariance matrix obtained from distributed soil moisture simulations. To assess the performance of the disaggregation schemes, soil moisture simulations from an integrated land surface-groundwater model, ParFlow.CLM in Baldry sub-catchment, Australia are used. ParFlow is a variably saturated sub-surface flow model that is coupled to the Common Land Model (CLM). Our results illustrate that the statistical disaggregation scheme performs better than the methods based on topographic data in approximating soil moisture distribution at a 60m scale. Moreover, the statistical disaggregation scheme maintains temporal correlation of simulated daily soil moisture while preserves the mean sub-basin soil moisture. Future work is focused on assessing the performance of this scheme in catchments with various topographic and climate settings.

  5. 10 CFR 36.55 - Personnel monitoring.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Operation of Irradiators... accident dose ranges (see 10 CFR 20.1501(c)). Each personnel dosimeter must be assigned to and worn by only... processed at least quarterly. (b) Other individuals who enter the radiation room of a panoramic irradiator...

  6. 10 CFR 36.55 - Personnel monitoring.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Operation of Irradiators... accident dose ranges (see 10 CFR 20.1501(c)). Each personnel dosimeter must be assigned to and worn by only... processed at least quarterly. (b) Other individuals who enter the radiation room of a panoramic irradiator...

  7. 10 CFR 36.55 - Personnel monitoring.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Operation of Irradiators... accident dose ranges (see 10 CFR 20.1501(c)). Each personnel dosimeter must be assigned to and worn by only... processed at least quarterly. (b) Other individuals who enter the radiation room of a panoramic irradiator...

  8. 10 CFR 36.55 - Personnel monitoring.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Operation of Irradiators... accident dose ranges (see 10 CFR 20.1501(c)). Each personnel dosimeter must be assigned to and worn by only... processed at least quarterly. (b) Other individuals who enter the radiation room of a panoramic irradiator...

  9. 10 CFR 36.55 - Personnel monitoring.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Operation of Irradiators... accident dose ranges (see 10 CFR 20.1501(c)). Each personnel dosimeter must be assigned to and worn by only... processed at least quarterly. (b) Other individuals who enter the radiation room of a panoramic irradiator...

  10. 48 CFR 227.7005 - Indirect notice of patent infringement claims.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Indirect notice of patent... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7005 Indirect notice of patent infringement claims. (a) A...

  11. 48 CFR 227.7005 - Indirect notice of patent infringement claims.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Indirect notice of patent... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7005 Indirect notice of patent infringement claims. (a) A...

  12. 47 CFR 101.1415 - Partitioning and disaggregation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... American Datum (NAD83). (d) Unjust enrichment. 12 GHz licensees that received a bidding credit and... SERVICES FIXED MICROWAVE SERVICES Multichannel Video Distribution and Data Service Rules for the 12.2-12.7 GHz Band § 101.1415 Partitioning and disaggregation. (a) MVDDS licensees are permitted to partition...

  13. 47 CFR 101.1415 - Partitioning and disaggregation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... American Datum (NAD83). (d) Unjust enrichment. 12 GHz licensees that received a bidding credit and... SERVICES FIXED MICROWAVE SERVICES Multichannel Video Distribution and Data Service Rules for the 12.2-12.7 GHz Band § 101.1415 Partitioning and disaggregation. (a) MVDDS licensees are permitted to partition...

  14. 47 CFR 101.1415 - Partitioning and disaggregation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... American Datum (NAD83). (d) Unjust enrichment. 12 GHz licensees that received a bidding credit and... SERVICES FIXED MICROWAVE SERVICES Multichannel Video Distribution and Data Service Rules for the 12.2-12.7 GHz Band § 101.1415 Partitioning and disaggregation. (a) MVDDS licensees are permitted to partition...

  15. 47 CFR 101.1415 - Partitioning and disaggregation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... American Datum (NAD83). (d) Unjust enrichment. 12 GHz licensees that received a bidding credit and... SERVICES FIXED MICROWAVE SERVICES Multichannel Video Distribution and Data Service Rules for the 12.2-12.7 GHz Band § 101.1415 Partitioning and disaggregation. (a) MVDDS licensees are permitted to partition...

  16. Cascade rainfall disaggregation application in U.S. Central Plains

    USDA-ARS?s Scientific Manuscript database

    Hourly rainfall are increasingly used in complex, process-based simulations of the environment. Long records of daily rainfall are common, but long continuous records of hourly rainfall are rare and must be developed. A Multiplicative Random Cascade (MRC) model is proposed to disaggregate observed d...

  17. 34 CFR 200.7 - Disaggregation of data.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Disaggregation of data. 200.7 Section 200.7 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving Basic...

  18. 34 CFR 200.7 - Disaggregation of data.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Disaggregation of data. 200.7 Section 200.7 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving Basic...

  19. Photoinduced Disaggregation of TiO2 Nanoparticles Enables Transdermal Penetration

    PubMed Central

    Bennett, Samuel W.; Zhou, Dongxu; Mielke, Randall; Keller, Arturo A.

    2012-01-01

    Under many aqueous conditions, metal oxide nanoparticles attract other nanoparticles and grow into fractal aggregates as the result of a balance between electrostatic and Van Der Waals interactions. Although particle coagulation has been studied for over a century, the effect of light on the state of aggregation is not well understood. Since nanoparticle mobility and toxicity have been shown to be a function of aggregate size, and generally increase as size decreases, photo-induced disaggregation may have significant effects. We show that ambient light and other light sources can partially disaggregate nanoparticles from the aggregates and increase the dermal transport of nanoparticles, such that small nanoparticle clusters can readily diffuse into and through the dermal profile, likely via the interstitial spaces. The discovery of photoinduced disaggregation presents a new phenomenon that has not been previously reported or considered in coagulation theory or transdermal toxicological paradigms. Our results show that after just a few minutes of light, the hydrodynamic diameter of TiO2 aggregates is reduced from ∼280 nm to ∼230 nm. We exposed pigskin to the nanoparticle suspension and found 200 mg kg−1 of TiO2 for skin that was exposed to nanoparticles in the presence of natural sunlight and only 75 mg kg−1 for skin exposed to dark conditions, indicating the influence of light on NP penetration. These results suggest that photoinduced disaggregation may have important health implications. PMID:23155401

  20. 43 CFR 6.53 - Unpatented inventions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

  1. 48 CFR 252.227-7000 - Non-estoppel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Non-estoppel. 252.227-7000... Clauses 252.227-7000 Non-estoppel. As prescribed at 227.7009-1, insert the following clause in patent releases, license agreements, and assignments: Non-Estoppel (OCT 1966) The Government reserves the right at...

  2. 47 CFR 1.2112 - Ownership disclosure requirements for applications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...., short-form application (see 47 CFR 1.2105)), or for a license, authorization, assignment, or transfer of... applicant or application, including a complete disclosure of the identity and relationship of those persons... of each such entity's relationship to the applicant (e.g., Company A owns 10 percent of Company B...

  3. 47 CFR 1.2112 - Ownership disclosure requirements for applications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...., short-form application (see 47 CFR 1.2105)), or for a license, authorization, assignment, or transfer of... applicant or application, including a complete disclosure of the identity and relationship of those persons... of each such entity's relationship to the applicant (e.g., Company A owns 10 percent of Company B...

  4. 76 FR 3892 - Notice of Public Information Collection(s) Being Reviewed by the Federal Communications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... potential for harmful interference to adjacent Wireless Communications Service (WCS) spectrum users by...) average equivalent isotropically radiated power (EIRP) to facilitate the flexible deployment of SDARS... qualifications of SDARS applicants or licensees to operate a station, transfer or assign a license, and to...

  5. 77 FR 41203 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ..., Tortola, British Virgin Islands. The patent rights in these inventions have been assigned to the United... submitted to Patent Counsel, Office of the Chief Counsel, NASA Johnson Space Center, 2101 NASA Parkway, Mail...: Ted Ro, Intellectual Property Attorney, Office of Chief Counsel, NASA Johnson Space Center, 2101 NASA...

  6. 77 FR 45696 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ..., Tortola, British Virgin Islands. The patent rights in these inventions have been assigned to the United... submitted to Patent Counsel, Office of the Chief Counsel, NASA Johnson Space Center, 2101 NASA Parkway...: Ted Ro, Intellectual Property Attorney, Office of Chief Counsel, NASA Johnson Space Center, 2101 NASA...

  7. 47 CFR 90.631 - Trunked systems loading, construction and authorization requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Regulations Governing Licensing and... Processing of Applications and the Selection and Assignment of Frequencies for Use in the 806-824 Mhz, 851... one hundred (100) mobile stations per channel. For purposes of determining compliance with trunked...

  8. 47 CFR 3.22 - Number of accounting authority identification codes per applicant.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.22 Number of accounting authority identification codes per applicant... assign U.S. AAICs for entities settling accounts of U.S. licensed vessels in the maritime mobile and...

  9. 43 CFR 6.53 - Unpatented inventions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

  10. 43 CFR 6.53 - Unpatented inventions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

  11. 43 CFR 6.53 - Unpatented inventions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

  12. 43 CFR 6.53 - Unpatented inventions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

  13. 19 CFR 123.92 - Electronic information for truck cargo required in advance of arrival.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and exportation, in another vehicle or conveyance are also subject to the advance electronic... Vehicle Identification Number (VIN) or its license plate number and state of issuance; the equipment... number to be assigned by CBP upon the implementation of the Automated Commercial Environment); and (12...

  14. 19 CFR 123.92 - Electronic information for truck cargo required in advance of arrival.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and exportation, in another vehicle or conveyance are also subject to the advance electronic... Vehicle Identification Number (VIN) or its license plate number and state of issuance; the equipment... number to be assigned by CBP upon the implementation of the Automated Commercial Environment); and (12...

  15. 10 CFR 55.33 - Disposition of an initial application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... performance of assigned operator job duties or cause operational errors endangering public health and safety... and tests determine whether the applicant for an operator's license has learned to operate a facility competently and safely, and additionally, in the case of a senior operator, whether the applicant has learned...

  16. 47 CFR 64.5103 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... VRS access technology. Such calls are made by means of ten-digit NANP numbers assigned to customers by...'s social security number, or the last four digits of that number; mother's maiden name; home address... driver's license, passport, or comparable ID that has not expired. (v) Video relay service. The term...

  17. 47 CFR 64.5103 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... VRS access technology. Such calls are made by means of ten-digit NANP numbers assigned to customers by...'s social security number, or the last four digits of that number; mother's maiden name; home address... driver's license, passport, or comparable ID that has not expired. (v) Video relay service. The term...

  18. A comparative analysis of two highly spatially resolved European atmospheric emission inventories

    NASA Astrophysics Data System (ADS)

    Ferreira, J.; Guevara, M.; Baldasano, J. M.; Tchepel, O.; Schaap, M.; Miranda, A. I.; Borrego, C.

    2013-08-01

    A reliable emissions inventory is highly important for air quality modelling applications, especially at regional or local scales, which require high resolutions. Consequently, higher resolution emission inventories have been developed that are suitable for regional air quality modelling. This research performs an inter-comparative analysis of different spatial disaggregation methodologies of atmospheric emission inventories. This study is based on two different European emission inventories with different spatial resolutions: 1) the EMEP (European Monitoring and Evaluation Programme) inventory and 2) an emission inventory developed by the TNO (Netherlands Organisation for Applied Scientific Research). These two emission inventories were converted into three distinct gridded emission datasets as follows: (i) the EMEP emission inventory was disaggregated by area (EMEParea) and (ii) following a more complex methodology (HERMES-DIS - High-Elective Resolution Modelling Emissions System - DISaggregation module) to understand and evaluate the influence of different disaggregation methods; and (iii) the TNO gridded emissions, which are based on different emission data sources and different disaggregation methods. A predefined common grid with a spatial resolution of 12 × 12 km2 was used to compare the three datasets spatially. The inter-comparative analysis was performed by source sector (SNAP - Selected Nomenclature for Air Pollution) with emission totals for selected pollutants. It included the computation of difference maps (to focus on the spatial variability of emission differences) and a linear regression analysis to calculate the coefficients of determination and to quantitatively measure differences. From the spatial analysis, greater differences were found for residential/commercial combustion (SNAP02), solvent use (SNAP06) and road transport (SNAP07). These findings were related to the different spatial disaggregation that was conducted by the TNO and HERMES-DIS for the first two sectors and to the distinct data sources that were used by the TNO and HERMES-DIS for road transport. Regarding the regression analysis, the greatest correlation occurred between the EMEParea and HERMES-DIS because the latter is derived from the first, which does not occur for the TNO emissions. The greatest correlations were encountered for agriculture NH3 emissions, due to the common use of the CORINE Land Cover database for disaggregation. The point source emissions (energy industries, industrial processes, industrial combustion and extraction/distribution of fossil fuels) resulted in the lowest coefficients of determination. The spatial variability of SOx differed among the emissions that were obtained from the different disaggregation methods. In conclusion, HERMES-DIS and TNO are two distinct emission inventories, both very well discretized and detailed, suitable for air quality modelling. However, the different databases and distinct disaggregation methodologies that were used certainly result in different spatial emission patterns. This fact should be considered when applying regional atmospheric chemical transport models. Future work will focus on the evaluation of air quality models performance and sensitivity to these spatial discrepancies in emission inventories. Air quality modelling will benefit from the availability of appropriate resolution, consistent and reliable emission inventories.

  19. A Methodology for the Optimization of Disaggregated Space System Conceptual Designs

    DTIC Science & Technology

    2015-06-18

    orbit disaggregated space systems. Savings of $82 million are identified for an optimized fire detection system. Savings of $5.7 billion are...solutions and update architecture ................................................................31 Fire detection problem...149 Figure 30 – Example cost vs. weighted mean science return output [37] ...................... 153 Figure 31

  20. Disaggregating Assessment to Close the Loop and Improve Student Learning

    ERIC Educational Resources Information Center

    Rawls, Janita; Hammons, Stacy

    2015-01-01

    This study examined student learning outcomes for accelerated degree students as compared to conventional undergraduate students, disaggregated by class levels, to develop strategies for then closing the loop with assessment. Using the National Survey of Student Engagement, critical thinking and oral and written communication outcomes were…

  1. Effects of slaking and mechanical breakdown on disaggregation and splash erosion

    USDA-ARS?s Scientific Manuscript database

    The contributions of different aggregate breakdown mechanisms to splash erosion are still obscure. This study was designed to investigate the effects of different soil disaggregation mechanisms on splash erosion. Loam clay soil, clay loam soil, and sandy loam soil were used in this study. Soil aggre...

  2. Freight Demand Characteristics and Mode Choice: An Analysis of the Results of Modeling with Disaggregate Revealed Preference Data

    DOT National Transportation Integrated Search

    1999-12-01

    This paper analyzes the freight demand characteristics that drive modal choice by means of a large scale, national, disaggregate revealed preference database for shippers in France in 1988, using a nested logit. Particular attention is given to priva...

  3. Aggregation and disaggregation dynamics of sedimented and charged superparamagnetic micro-particles in water suspension.

    PubMed

    Domínguez-García, P; Pastor, J M; Rubio, M A

    2011-04-01

    This article presents results on the aggregation and disaggregation kinetics on a 1 μm diameter charged superparamagnetic particles dispersed in water under a constant uniaxial magnetic field in experiments with salt (KCl) added to the suspension in order to observe the behaviour of the system when the electrical properties of the particles have been screened. These particles have an electric charge and are confined between two separated 100 μm thick quartz windows, and sediment near the charged bottom wall. The electrostatic interactions that take place in this experimental setup may affect the micro-structure and colloidal stability of the suspension and thus, the dynamics of aggregation and disaggregation.

  4. 77 FR 26531 - Request for Information To Gather Technical Expertise Pertaining to the Disaggregation of Asian...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... information to help State educational agencies (SEAs), local educational agencies (LEAs), schools, and... student population. SEAs, LEAs, schools, and IHEs might then use those data to improve their ability to... seeking information on disaggregation practices that SEAs, LEAs, schools, and IHEs use when collecting and...

  5. Electrical service reliability: the customer perspective

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Samsa, M.E.; Hub, K.A.; Krohm, G.C.

    1978-09-01

    Electric-utility-system reliability criteria have traditionally been established as a matter of utility policy or through long-term engineering practice, generally with no supportive customer cost/benefit analysis as justification. This report presents results of an initial study of the customer perspective toward electric-utility-system reliability, based on critical review of over 20 previous and ongoing efforts to quantify the customer's value of reliable electric service. A possible structure of customer classifications is suggested as a reasonable level of disaggregation for further investigation of customer value, and these groups are characterized in terms of their electricity use patterns. The values that customers assign tomore » reliability are discussed in terms of internal and external cost components. A list of options for effecting changes in customer service reliability is set forth, and some of the many policy issues that could alter customer-service reliability are identified.« less

  6. Citizenship beyond politics: the importance of political, civil and social rights and responsibilities among women and men.

    PubMed

    Bolzendahl, Catherine; Coffé, Hilde

    2009-12-01

    Previous research has suggested that men are more engaged as citizens than are women. Yet, little is known about gender cleavages across a variety of citizenship norms. To what extent do men and women define citizenship differently? To address that question, this study examines the importance men and women assign various citizenship rights and responsibilities using 2004 ISSP data from 18 Western, industrialized nations. Using a disaggregated approach to understanding definitions of citizenship, we examine political, civil, and social rights and responsibilities. After controlling for a variety of demographic and attitudinal influences, we find that men and women are not different in their views regarding the importance of political responsibilities. However, women do view political rights as significantly more important than do men. Further, in comparison to men, women view both civil and social responsibilities and rights domains as significantly more important.

  7. A decade of sea level rise slowed by climate-driven hydrology.

    PubMed

    Reager, J T; Gardner, A S; Famiglietti, J S; Wiese, D N; Eicker, A; Lo, M-H

    2016-02-12

    Climate-driven changes in land water storage and their contributions to sea level rise have been absent from Intergovernmental Panel on Climate Change sea level budgets owing to observational challenges. Recent advances in satellite measurement of time-variable gravity combined with reconciled global glacier loss estimates enable a disaggregation of continental land mass changes and a quantification of this term. We found that between 2002 and 2014, climate variability resulted in an additional 3200 ± 900 gigatons of water being stored on land. This gain partially offset water losses from ice sheets, glaciers, and groundwater pumping, slowing the rate of sea level rise by 0.71 ± 0.20 millimeters per year. These findings highlight the importance of climate-driven changes in hydrology when assigning attribution to decadal changes in sea level. Copyright © 2016, American Association for the Advancement of Science.

  8. Disaggregation of silver nanoparticle homoaggregates in a river water matrix.

    PubMed

    Metreveli, George; Philippe, Allan; Schaumann, Gabriele E

    2015-12-01

    Silver nanoparticles (Ag NPs) could be found in aquatic systems in the near future. Although the interplay between aggregate formation and disaggregation is an important factor for mobility, bioavailability and toxicity of Ag NPs in surface waters, the factors controlling disaggregation of Ag NP homoaggregates are still unknown. In this study, we investigated the reversibility of homoaggregation of citrate coated Ag NPs in a Rhine River water matrix. We characterized the disaggregation of Ag NP homoaggregates by ionic strength reduction and addition of Suwannee River humic acid (SRHA) in the presence of strong and weak shear forces. In order to understand the disaggregation processes, we also studied the nature of homoaggregates and their formation dynamics under the influence of SRHA, Ca(2+) concentration and nanoparticle concentration. Even in the presence of SRHA and at low particle concentrations (10 μg L(-1)), aggregates formed rapidly in filtered Rhine water. The critical coagulation concentration (CCC) of Ca(2+) in reconstituted Rhine water was 1.5 mmol L(-1) and was shifted towards higher values in the presence of SRHA. Analysis of the attachment efficiency as a function of Ca(2+) concentration showed that SRHA induces electrosteric stabilization at low Ca(2+) concentrations and cation-bridging flocculation at high Ca(2+) concentrations. Shear forces in the form of mechanical shaking or ultrasound were necessary for breaking the aggregates. Without ultrasound, SRHA also induced disaggregation, but it required several days to reach a stable size of dense aggregates still larger than the primary particles. Citrate stabilized Ag NPs may be in the form of reaction limited aggregates in aquatic systems similar to the Rhine River. The size and the structure of these aggregates will be dynamic and be determined by the solution conditions. Seasonal variations in the chemical composition of natural waters can result in a sedimentation-release cycle of engineered nanoparticles. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Mathematics in the Real World: How People in Different Professions Use Mathematics.

    ERIC Educational Resources Information Center

    Rule, Audrey C., Ed.

    This paper reports on a class assignment written by preservice teachers on the use of mathematics in different professions. The professions included licensed practical nurse, auto mechanic, research and development product manager for industrial cleaning products, dental office assistant, snack bar employee at a beach club, beauty salon owner and…

  10. 48 CFR 227.7011 - Procurement of rights in inventions, patents, and copyrights.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Government's interest to do so and the desired rights can be obtained at a fair price. The... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Procurement of rights in... COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7011 Procurement of rights in inventions...

  11. 32 CFR 37.550 - May I accept intellectual property as cost sharing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... software) as cost sharing, because: (1) It is difficult to assign values to these intangible contributions... offer the use of commercially available software for which there is an established license fee for use of the product. The costs of the development of the software would not be a reasonable basis for...

  12. 32 CFR 37.550 - May I accept intellectual property as cost sharing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... offer the use of commercially available software for which there is an established license fee for use of the product. The costs of the development of the software would not be a reasonable basis for... software) as cost sharing, because: (1) It is difficult to assign values to these intangible contributions...

  13. 77 FR 22389 - State of Michigan Department of Transportation-Acquisition Exemption-Certain Assets of Norfolk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ..., NSR will retain an exclusive, irrevocable, perpetual, assignable, divisible, licensable and transferable freight operations easement to provide freight rail service on the line.\\1\\ \\1\\ A motion to... expedited consideration to the motion and issue a decision effective by May 31, 2012. The motion to dismiss...

  14. 77 FR 16033 - Sunshine Act Meeting; Open Commission Meeting; Wednesday, March 21, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ...., Transferors, and Liberty Media Corporation, Transferee, for Authority to Transfer Control (MB Docket No. 07-18) and Applications for Consent to the Assignment and/or Transfer of Control of Licenses, Adelphia.... 2 MEDIA Title: Creation of a Low Power Radio Service (MM Docket No. 99-25) and Amendment of Service...

  15. 47 CFR 90.735 - Station identification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MOBILE RADIO SERVICES Regulations Governing Licensing and Use of Frequencies in the 220-222 MHz Band § 90... shall be made on the lowest frequency in the base station trunked group assigned to the licensee. If this frequency is in use at the time identification is required, the identification may be made at the...

  16. 47 CFR 101.103 - Frequency coordination procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Assignment of frequencies will be made only in such a manner as to facilitate the rendition of communication...-point basis may not be extended or otherwise modified through the addition of point-to-point links. Such... modified through the addition of point-to-point links. Such operations licensed on a point-to-radius basis...

  17. 47 CFR 101.103 - Frequency coordination procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Assignment of frequencies will be made only in such a manner as to facilitate the rendition of communication...-point basis may not be extended or otherwise modified through the addition of point-to-point links. Such... modified through the addition of point-to-point links. Such operations licensed on a point-to-radius basis...

  18. 47 CFR 101.103 - Frequency coordination procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Assignment of frequencies will be made only in such a manner as to facilitate the rendition of communication...-point basis may not be extended or otherwise modified through the addition of point-to-point links. Such... modified through the addition of point-to-point links. Such operations licensed on a point-to-radius basis...

  19. 19 CFR 123.92 - Electronic information for truck cargo required in advance of arrival.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and exportation, in another vehicle or conveyance are also subject to the advance electronic... of the conveyance is its Vehicle Identification Number (VIN) or its license plate number and state of... number will be a unique number to be assigned by CBP upon the implementation of the Automated Commercial...

  20. 19 CFR 123.92 - Electronic information for truck cargo required in advance of arrival.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and exportation, in another vehicle or conveyance are also subject to the advance electronic... of the conveyance is its Vehicle Identification Number (VIN) or its license plate number and state of... number will be a unique number to be assigned by CBP upon the implementation of the Automated Commercial...

  1. 76 FR 30322 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... below are assigned to the United States Government as represented by the Secretary of the Navy. U.S... ``Automatic Clock Synchronization and Distribution Circuit for Counter Clock Flow Pipelined Systems'' issued... Flow and Metallic Conformal Coating of Conductive Templates'' issued on October 12, 2010; U.S. Patent...

  2. 77 FR 22720 - Service Rules for Advanced Wireless Services in the 2000-2020 MHz and 2180-2200 MHz Bands, etc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ..., encourage innovation and investment in mobile broadband, and provide a stable regulatory environment in... of this spectrum, to encourage innovation and investment in mobile broadband, and to provide a stable... service, technical, assignment, and licensing rules for flexible terrestrial use of spectrum currently...

  3. 75 FR 73976 - Policies To Promote Rural Radio Service and To Streamline Allotment and Assignment Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Commission removed FCC Form 302-DTV, Application for Digital Television Broadcast Station License, and FCC... Commission added a new Section 307(b) priority that would apply only to Native American and Alaska Native... federally recognized Native American Tribes and Alaska Native Villages (``Tribes''), enrolled members of...

  4. 45 CFR 286.255 - What quarterly reports must the Tribe submit to us?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false What quarterly reports must the Tribe submit to us... must the Tribe submit to us? (a) Quarterly reports. Each Tribe must collect on a monthly basis, and... Data Report: Disaggregated Data—Sections one and two. Each Tribe must file disaggregated information on...

  5. The Disaggregation of Value-Added Test Scores to Assess Learning Outcomes in Economics Courses

    ERIC Educational Resources Information Center

    Walstad, William B.; Wagner, Jamie

    2016-01-01

    This study disaggregates posttest, pretest, and value-added or difference scores in economics into four types of economic learning: positive, retained, negative, and zero. The types are derived from patterns of student responses to individual items on a multiple-choice test. The micro and macro data from the "Test of Understanding in College…

  6. Fate of mRNA following disaggregation of brain polysomes after administration of (+)-lysergic acid diethylamide in vivo.

    PubMed

    Mahony, J B; Brown, I R

    1979-11-22

    Intravenous injection of (+)-lysergic acid diethylamide into young rabbits induced a transient brain-specific disaggregation of polysomes to monosomes. Investigation of the fate of mRNA revealed that brain poly(A+)mRNA was conserved. In particular, mRNA coding for brain-specific S100 protein was not degraded, nor was it released into free ribonucleoprotein particles. Following the (+)-lysergic acid diethylamide-induced disaggregation of polysomes, mRNA shifted from polysomes and accumulated on monosomes. Formation of a blocked monosome complex, which contained intact mRNA and 40-S plus 60-S ribosomal subunits but lacked nascent peptide chains, suggested that (+)-lysergic acid diethylamide inhibited brain protein synthesis at a specific stage of late initiation or early elongation.

  7. A programmable Si-photonic node for SDN-enabled Bloom filter forwarding in disaggregated data centers

    NASA Astrophysics Data System (ADS)

    Moralis-Pegios, M.; Terzenidis, N.; Vagionas, C.; Pitris, S.; Chatzianagnostou, E.; Brimont, A.; Zanzi, A.; Sanchis, P.; Marti, J.; Kraft, J.; Rochracher, K.; Dorrestein, S.; Bogdan, M.; Tekin, T.; Syrivelis, D.; Tassiulas, L.; Miliou, A.; Pleros, N.; Vyrsokinos, K.

    2017-02-01

    Programmable switching nodes supporting Software-Defined Networking (SDN) over optical interconnecting technologies arise as a key enabling technology for future disaggregated Data Center (DC) environments. The SDNenabling roadmap of intra-DC optical solutions is already a reality for rack-to-rack interconnects, with recent research reporting on interesting applications of programmable silicon photonic switching fabrics addressing board-to-board and even on-board applications. In this perspective, simplified information addressing schemes like Bloom filter (BF)-based labels emerge as a highly promising solution for ensuring rapid switch reconfiguration, following quickly the changes enforced in network size, network topology or even in content location. The benefits of BF-based forwarding have been so far successfully demonstrated in the Information-Centric Network (ICN) paradigm, while theoretical studies have also revealed the energy consumption and speed advantages when applied in DCs. In this paper we present for the first time a programmable 4x4 Silicon Photonic switch that supports SDN through the use of BF-labeled router ports. Our scheme significantly simplifies packet forwarding as it negates the need for large forwarding tables, allowing for its remote control through modifications in the assigned BF labels. We demonstrate 1x4 switch operation controlling the Si-Pho switch by a Stratix V FPGA module, which is responsible for processing the packet ID and correlating its destination with the appropriate BF-labeled outgoing port. DAC- and amplifier-less control of the carrier-injection Si-Pho switches is demonstrated, revealing successful switching of 10Gb/s data packets with BF-based forwarding information changes taking place at a time-scale that equals the duration of four consecutive packets.

  8. Comparison of CO2 Emissions Data for 30 Cities from Different Sources

    NASA Astrophysics Data System (ADS)

    Nakagawa, Y.; Koide, D.; Ito, A.; Saito, M.; Hirata, R.

    2017-12-01

    Many sources suggest that cities account for a large proportion of global anthropogenic greenhouse gas emissions. Therefore, in search for the best ways to reduce total anthropogenic greenhouse gas emissions, a focus on the city emission is crucial. In this study, we collected CO2 emissions data in 30 cities during 1990-2015 and evaluated the degree of variance between data sources. The CO2 emissions data were obtained from academic papers, municipal reports, and high-resolution emissions maps (CIDIACv2016, EDGARv4.2, ODIACv2016, and FFDASv2.0). To extract urban CO2 emissions from the high-resolution emissions maps, urban fraction ranging from 0 to 1 was calculated for each 1×1 degree grid cell using the global land cover data (SYNMAP). Total CO2 emissions from the grid cells in which urban fraction occupies greater than or equal to 0.9 were regarded as urban CO2 emissions. The estimated CO2 emissions varied greatly depending on the information sources, even in the same year. There was a large difference between CO2 emissions collected from academic papers, municipal reports, and those extracted from high-resolution emissions maps. One reason is that they use different city boundaries. That is, the city proper (i.e. the political city boundary) is often defined as the city boundary in academic papers and municipal reports, whereas the urban area is used in the high-resolution emissions maps. Furthermore, there was a large variation in CO2 emissions collected from academic papers and municipal reports. These differences may be due to the difference in the assumptions such as allocation ratio of CO2 emissions to producers and consumers. In general, the consumption-based assignment of emissions gives higher estimates of urban CO2 emission in comparison with production-based assignment. Furthermore, there was also a large variation in CO2 emissions extracted from high-resolution emissions maps. This difference would be attributable to differences in information used in the spatial disaggregation of emissions. To identify the CO2 emissions from cities, it is necessary to determine common definitions of city boundaries, allocation ratio of CO2 emissions to consumption and production, and refined approach of the spatial disaggregation of CO2 emissions in high-resolution emissions maps.

  9. Characterization and disaggregation of daily rainfall in the Upper Blue Nile Basin in Ethiopia

    NASA Astrophysics Data System (ADS)

    Engida, Agizew N.; Esteves, Michel

    2011-03-01

    SummaryIn Ethiopia, available rainfall records are mainly limited to daily time steps. Though rainfall data at shorter time steps are important for various purposes like modeling of erosion processes and flood hydrographs, they are hardly available in Ethiopia. The objectives of this study were (i) to study the temporal characteristics of daily rains at two stations in the region of the Upper Blue Nile Basin (UBNB) and (ii) to calibrate and evaluate a daily rainfall disaggregation model. The analysis was based on rainfall data of Bahir Dar and Gonder Meteorological Stations. The disaggregation model used was the Modified Bartlett-Lewis Rectangular Pulse Model (MBLRPM). The mean daily rainfall intensity varied from about 4 mm in the dry season to 17 mm in the wet season with corresponding variation in raindays of 0.4-26 days. The observed maximum daily rainfall varied from 13 mm in the dry month to 200 mm in the wet month. The average wet/dry spell length varied from 1/21 days in the dry season to 6/1 days in the rainy season. Most of the rainfall occurs in the afternoon and evening periods of the day. Daily rainfall disaggregation using the MBLRPM alone resulted in poor match between the disaggregated and observed hourly rainfalls. Stochastic redistribution of the outputs of the model using Beta probability distribution function improved the agreement between observed and calculated hourly rain intensities. In areas where convective rainfall is dominant, the outputs of MBLRPM should be redistributed using relevant probability distributions to simulate the diurnal rainfall pattern.

  10. The Economic Impact of Higher Education Institutions in Ireland: Evidence from Disaggregated Input-Output Tables

    ERIC Educational Resources Information Center

    Zhang, Qiantao; Larkin, Charles; Lucey, Brian M.

    2017-01-01

    While there has been a long history of modelling the economic impact of higher education institutions (HEIs), little research has been undertaken in the context of Ireland. This paper provides, for the first time, a disaggregated input-output table for Ireland's higher education sector. The picture painted overall is a higher education sector that…

  11. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.

    PubMed

    Boado, Ruben J; Zhang, Yufeng; Zhang, Yun; Xia, Chun-Fang; Pardridge, William M

    2007-01-01

    Delivery of monoclonal antibody therapeutics across the blood-brain barrier is an obstacle to the diagnosis or therapy of CNS disease with antibody drugs. The immune therapy of Alzheimer's disease attempts to disaggregate the amyloid plaque of Alzheimer's disease with an anti-Abeta monoclonal antibody. The present work is based on a three-step model of immune therapy of Alzheimer's disease: (1) influx of the anti-Abeta monoclonal antibody across the blood-brain barrier in the blood to brain direction, (2) binding and disaggregation of Abeta fibrils in brain, and (3) efflux of the anti-Abeta monoclonal antibody across the blood-brain barrier in the brain to blood direction. This is accomplished with the genetic engineering of a trifunctional fusion antibody that binds (1) the human insulin receptor, which mediates the influx from blood to brain across the blood-brain barrier, (2) the Abeta fibril to disaggregate amyloid plaque, and (3) the Fc receptor, which mediates the efflux from brain to blood across the blood-brain barrier. This fusion protein is a new antibody-based therapeutic for Alzheimer's disease that is specifically engineered to cross the human blood-brain barrier in both directions.

  12. 47 CFR 27.1168 - Triggering a Reimbursement Obligation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AWS entity or MSS/ATC entity has triggered a cost-sharing obligation and therefore must pay an AWS... co-channel with the licensed AWS band(s) of the AWS entity or the selected assignment of the MSS operator that seeks and obtains ATC authority (see § 25.149(a)(2)(i) of this chapter); (2) An AWS relocator...

  13. 47 CFR 27.1168 - Triggering a Reimbursement Obligation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AWS entity or MSS/ATC entity has triggered a cost-sharing obligation and therefore must pay an AWS... co-channel with the licensed AWS band(s) of the AWS entity or the selected assignment of the MSS operator that seeks and obtains ATC authority (see § 25.149(a)(2)(i) of this chapter); (2) An AWS relocator...

  14. 76 FR 36556 - Prospective Grant of Exclusive License; The Development of Ulipristal Acetate for the Treatment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of... Institutes of Health, Department of Health and Human Services, is contemplating the grant to PregLem SA of an... foreign counterparts. The patent rights in this invention have been assigned to the Government of the...

  15. CWC Industry Outreach III: - CWC Ratification, Implementation, Compliance and Verification (CWC Video). Volume 1. Main Report.

    DTIC Science & Technology

    1995-08-03

    asked whether the scheduled chemicals will be assigned individual ECCNs . They were interested in whether the normal trade license applications will be...the Australia Group? B-14 AC93MC1002 Has an effort been made or is one planned to coordinate the.trade requirements on these chemicals with the ECCNs

  16. 47 CFR 1.1107 - Schedule of charges for applications and other filings for the international services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Assignments or transfers (all services) Corres & 159 1,015.00 CUT 3. Fixed Satellite Transmit/Receive Earth... 175.00 CGX 4. Fixed Satellite transmit/receive Earth Stations (2 meters or less operating in the 4/6... Only Earth Stations: a. Initial Applications for Registration or License (per station) 312 Main...

  17. 19 CFR 123.92 - Electronic information for truck cargo required in advance of arrival.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... transportation and exportation, in another vehicle or conveyance are also subject to the advance electronic... of the conveyance is its Vehicle Identification Number (VIN) or its license plate number and state of... number will be a unique number to be assigned by CBP upon the implementation of the Automated Commercial...

  18. 47 CFR 74.602 - Frequency assignment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... segments 17,700-18,580 and 19,260-19,700 MHz are available for broadcast auxiliary stations as described in... operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that were licensed or had applications pending before the Commission as of September 18, 1998 may continue those operations on a shared...

  19. 47 CFR 74.602 - Frequency assignment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... segments 17,700-18,580 and 19,260-19,700 MHz are available for broadcast auxiliary stations as described in... operating on frequencies in the sub-bands 18.3-18.58 GHz and 19.26-19.3 GHz that were licensed or had applications pending before the Commission as of September 18, 1998 may continue those operations on a shared...

  20. Toward improved health: disaggregating Asian American and Native Hawaiian/Pacific Islander data.

    PubMed Central

    Srinivasan, S; Guillermo, T

    2000-01-01

    The 2000 census, with its option for respondents to mark 1 or more race categories, is the first US census to recognize the multiethnic nature of all US populations but especially Asian Americans and Native Hawaiians/Pacific Islanders. If Asian Americans and Native Hawaiians/Pacific Islanders have for the most part been "invisible" in policy debates regarding such matters as health care and immigration, it has been largely because of a paucity of data stemming from the lack of disaggregated data on this heterogeneous group of peoples. Studies at all levels should adhere to these disaggregated classifications. Also, in addition to oversampling procedures, there should be greater regional/local funding for studies in regions where Asian American and Native Hawaiian/Pacific Islander populations are substantial. PMID:11076241

  1. Factors Associated with Assignment of Therapeutic Homework in a Large Public Children's Mental Health System.

    PubMed

    Trask, Emily Velazquez; Barounis, Kya; Carlisle, Brandon L; Garland, Ann F; Aarons, Gregory A

    2018-03-24

    Therapeutic homework is a fundamental skill-building component of the majority of evidence-based therapies and is associated with better treatment outcomes. However, it is rarely utilized in public mental health settings. To determine barriers to homework use and identify predictors of clinicians' assignment of homework, an online survey was administered to 267 clinicians in a large diverse public mental health system. Clinicians who were younger, licensed, whose supervisors asked about homework and whose clients completed their homework more frequently were predictors of greater homework utilization. The survey results are discussed and a novel idea to increase the use of homework is introduced.

  2. A New Data Set of Educational Attainment in the World, 1950-2010. NBER Working Paper No. 15902

    ERIC Educational Resources Information Center

    Barro, Robert J.; Lee, Jong-Wha

    2010-01-01

    Our panel data set on educational attainment has been updated for 146 countries from 1950 to 2010. The data are disaggregated by sex and by 5-year age intervals. We have improved the accuracy of estimation by using information from consistent census data, disaggregated by age group, along with new estimates of mortality rates and completion rates…

  3. Converged photonic data storage and switch platform for exascale disaggregated data centers

    NASA Astrophysics Data System (ADS)

    Pitwon, R.; Wang, K.; Worrall, A.

    2017-02-01

    We report on a converged optically enabled Ethernet storage, switch and compute platform, which could support future disaggregated data center architectures. The platform includes optically enabled Ethernet switch controllers, an advanced electro-optical midplane and optically interchangeable generic end node devices. We demonstrate system level performance using optically enabled Ethernet disk drives and micro-servers across optical links of varied lengths.

  4. Development of an Asset Value Map for Disaster Risk Assessment in China by Spatial Disaggregation Using Ancillary Remote Sensing Data.

    PubMed

    Wu, Jidong; Li, Ying; Li, Ning; Shi, Peijun

    2018-01-01

    The extent of economic losses due to a natural hazard and disaster depends largely on the spatial distribution of asset values in relation to the hazard intensity distribution within the affected area. Given that statistical data on asset value are collected by administrative units in China, generating spatially explicit asset exposure maps remains a key challenge for rapid postdisaster economic loss assessment. The goal of this study is to introduce a top-down (or downscaling) approach to disaggregate administrative-unit level asset value to grid-cell level. To do so, finding the highly correlated "surrogate" indicators is the key. A combination of three data sets-nighttime light grid, LandScan population grid, and road density grid, is used as ancillary asset density distribution information for spatializing the asset value. As a result, a high spatial resolution asset value map of China for 2015 is generated. The spatial data set contains aggregated economic value at risk at 30 arc-second spatial resolution. Accuracy of the spatial disaggregation reflects redistribution errors introduced by the disaggregation process as well as errors from the original ancillary data sets. The overall accuracy of the results proves to be promising. The example of using the developed disaggregated asset value map in exposure assessment of watersheds demonstrates that the data set offers immense analytical flexibility for overlay analysis according to the hazard extent. This product will help current efforts to analyze spatial characteristics of exposure and to uncover the contributions of both physical and social drivers of natural hazard and disaster across space and time. © 2017 Society for Risk Analysis.

  5. 43 CFR 3000.12 - What is the fee schedule for fixed fees?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What is the fee schedule for fixed fees... publication of a final rule in the Federal Register and will subsequently be posted on the BLM Web site (http... of lands 105 plus per acre nomination fee 0.11 Site license application 55 Assignment or transfer of...

  6. 77 FR 70484 - Preoperational Testing of Onsite Electric Power Systems To Verify Proper Load Group Assignments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... publicly available documents online in the NRC Library at http://www.nrc.gov/reading-rm/adams.html . To... reproduce them. NRC's PDR: You may examine and purchase copies of public documents at the NRC's PDR, Room O1... that the staff needs in its review of applications for permits and licenses. The draft regulatory guide...

  7. Collaborative Learning in Higher Education: Evoking Positive Interdependence.

    PubMed

    Scager, Karin; Boonstra, Johannes; Peeters, Ton; Vulperhorst, Jonne; Wiegant, Fred

    Collaborative learning is a widely used instructional method, but the learning potential of this instructional method is often underused in practice. Therefore, the importance of various factors underlying effective collaborative learning should be determined. In the current study, five different life sciences undergraduate courses with successful collaborative-learning results were selected. This study focuses on factors that increased the effectiveness of collaboration in these courses, according to the students. Nine focus group interviews were conducted and analyzed. Results show that factors evoking effective collaboration were student autonomy and self-regulatory behavior, combined with a challenging, open, and complex group task that required the students to create something new and original. The design factors of these courses fostered a sense of responsibility and of shared ownership of both the collaborative process and the end product of the group assignment. In addition, students reported the absence of any free riders in these group assignments. Interestingly, it was observed that students seemed to value their sense of achievement, their learning processes, and the products they were working on more than their grades. It is concluded that collaborative learning in higher education should be designed using challenging and relevant tasks that build shared ownership with students. © 2016 K. Scager et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  8. Differences in metacognitive regulation in introductory biology students: when prompts are not enough.

    PubMed

    Stanton, Julie Dangremond; Neider, Xyanthe N; Gallegos, Isaura J; Clark, Nicole C

    2015-01-01

    Strong metacognition skills are associated with learning outcomes and student performance. Metacognition includes metacognitive knowledge-our awareness of our thinking-and metacognitive regulation-how we control our thinking to facilitate learning. In this study, we targeted metacognitive regulation by guiding students through self-evaluation assignments following the first and second exams in a large introductory biology course (n = 245). We coded these assignments for evidence of three key metacognitive-regulation skills: monitoring, evaluating, and planning. We found that nearly all students were willing to take a different approach to studying but showed varying abilities to monitor, evaluate, and plan their learning strategies. Although many students were able to outline a study plan for the second exam that could effectively address issues they identified in preparing for the first exam, only half reported that they followed their plans. Our data suggest that prompting students to use metacognitive-regulation skills is effective for some students, but others need help with metacognitive knowledge to execute the learning strategies they select. Using these results, we propose a continuum of metacognitive regulation in introductory biology students. By refining this model through further study, we aim to more effectively target metacognitive development in undergraduate biology students. © 2015 J. D. Stanton et al. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  9. Equity in health care financing in Palestine: the value-added of the disaggregate approach.

    PubMed

    Abu-Zaineh, Mohammad; Mataria, Awad; Luchini, Stéphane; Moatti, Jean-Paul

    2008-06-01

    This paper analyzes the redistributive effect and progressivity associated with the current health care financing schemes in the Occupied Palestinian Territory, using data from the first Palestinian Household Health Expenditure Survey conducted in 2004. The paper goes beyond the commonly used "aggregate summary index approach" to apply a more detailed "disaggregate approach". Such an approach is borrowed from the general economic literature on taxation, and examines redistributive and vertical effects over specific parts of the income distribution, using the dominance criterion. In addition, the paper employs a bootstrap method to test for the statistical significance of the inequality measures. While both the aggregate and disaggregate approaches confirm the pro-rich and regressive character of out-of-pocket payments, the aggregate approach does not ascertain the potential progressive feature of any of the available insurance schemes. The disaggregate approach, however, significantly reveals a progressive aspect, for over half of the population, of the government health insurance scheme, and demonstrates that the regressivity of the out-of-pocket payments is most pronounced among the worst-off classes of the population. Recommendations are advanced to improve the performance of the government insurance schemes to enhance its capacity in limiting inequalities in health care financing in the Occupied Palestinian Territory.

  10. Visions and reality: the idea of competence-oriented assessment for German medical students is not yet realised in licensing examinations

    PubMed Central

    Huber-Lang, Markus; Palmer, Annette; Grab, Claudia; Boeckers, Anja; Boeckers, Tobias Maria; Oechsner, Wolfgang

    2017-01-01

    Objective: Competence orientation, often based on the CanMEDS model, has become an important goal for modern curricula in medical education. The National Competence Based Catalogue of Learning Objectives for Undergraduate Medical Education (NKLM) has been adopted in Germany. However, it is currently unknown whether the vision of competence orientation has also reached the licensing examination procedures. Methods: Therefore, a prospective, descriptive, single-centre, exemplary study design was applied to evaluate 4051 questions/tasks (from 28 examiners at 7 two-day licensing oral-practical exams) for undergraduate medical students at the University of Ulm. The oral and practical questions/tasks as well as the real bedside assessment were assigned to specific competence roles (NKLM section I), categories (NKLM section II) and taxonomy levels of learning domains. Results: Numerous questions/tasks were set per candidate (day 1/2: 70±24/86±19 questions) in the licensing oral-practical exam. Competence roles beyond the “medical expert” were scarcely considered. Furthermore, practical and communication skills at the bedside were hardly addressed (less than 3/15 min). Strikingly, there was a significant predominance of questions with a low-level taxonomy. Conclusions: The data indicate a misalignment of competence-oriented frameworks and the “real world” licensing practical-oral medical exam, which needs improvement in both evaluation and education processes. PMID:28584873

  11. Exploring the Functioning of Decision Space: A Review of the Available Health Systems Literature.

    PubMed

    Roman, Tamlyn Eslie; Cleary, Susan; McIntyre, Diane

    2017-02-27

    The concept of decision space holds appeal as an approach to disaggregating the elements that may influence decision-making in decentralized systems. This narrative review aims to explore the functioning of decision space and the factors that influence decision space. A narrative review of the literature was conducted with searches of online databases and academic journals including PubMed Central, Emerald, Wiley, Science Direct, JSTOR, and Sage. The articles were included in the review based on the criteria that they provided insight into the functioning of decision space either through the explicit application of or reference to decision space, or implicitly through discussion of decision-making related to organizational capacity or accountability mechanisms. The articles included in the review encompass literature related to decentralisation, management and decision space. The majority of the studies utilise qualitative methodologies to assess accountability mechanisms, organisational capacities such as finance, human resources and management, and the extent of decision space. Of the 138 articles retrieved, 76 articles were included in the final review. The literature supports Bossert's conceptualization of decision space as being related to organizational capacities and accountability mechanisms. These functions influence the decision space available within decentralized systems. The exact relationship between decision space and financial and human resource capacities needs to be explored in greater detail to determine the potential influence on system functioning. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  12. Physical Properties of Human Whole Salivary Mucin:A Dynamic Light Scattering Study

    NASA Astrophysics Data System (ADS)

    Mahajan, Manish; Kumar, Vijay; Saraswat, Mayank; Yadav, Savita; Shukla, N. K.; Singh, T. P.

    2008-04-01

    Human salivary mucin, a primary mucous membrane coating glycoprotein forms the first line of defense against adverse environments, attributed to the complex formation between mucin subunits and non mucin species. Aim of the study was to emphasize the effect of pH, denaturants (guanidinum hydrochloride, urea) and detergents (CHAPS, TRITON X -100, SDS on human whole salivary mucin. Hydrodynamic size distribution was measured using DLS. It was observed that aggregation was due to increase in hydrophobic interactions, believed to be accomplished by unfolding of the protein core. Whereas, the detergents which solubilize the proteins by decreasing hydrophobicity lead to disaggregation of mucin into smaller fragments. Mucin subjected to tobacco extract and upon subsequent addition of nicotine was found to have a disaggregating effect on it, suggesting nicotine may be one of the factors responsible for the disaggregating effect of tobacco on mucin, an important carcinogenetic mechanism.

  13. Spatial and temporal disaggregation of transport-related carbon dioxide emissions in Bogota - Colombia

    NASA Astrophysics Data System (ADS)

    Hernandez-Gonzalez, L. A.; Jimenez Pizarro, R.; Néstor Y. Rojas, N. Y.

    2011-12-01

    As a result of rapid urbanization during the last 60 years, 75% of the Colombian population now lives in cities. Urban areas are net sources of greenhouse gases (GHG) and contribute significantly to national GHG emission inventories. The development of scientifically-sound GHG mitigation strategies require accurate GHG source and sink estimations. Disaggregated inventories are effective mitigation decision-making tools. The disaggregation process renders detailed information on the distribution of emissions by transport mode, and the resulting a priori emissions map allows for optimal definition of sites for GHG flux monitoring, either by eddy covariance or inverse modeling techniques. Fossil fuel use in transportation is a major source of carbon dioxide (CO2) in Bogota. We present estimates of CO2 emissions from road traffic in Bogota using the Intergovernmental Panel on Climate Change (IPCC) reference method, and a spatial and temporal disaggregation method. Aggregated CO2 emissions from mobile sources were estimated from monthly and annual fossil fuel (gasoline, diesel and compressed natural gas - CNG) consumption statistics, and estimations of bio-ethanol and bio-diesel use. Although bio-fuel CO2 emissions are considered balanced over annual (or multi-annual) agricultural cycles, we included them since CO2 generated by their combustion would be measurable by a net flux monitoring system. For the disaggregation methodology, we used information on Bogota's road network classification, mean travel speed and trip length for each vehicle category and road type. The CO2 emission factors were taken from recent in-road measurements for gasoline- and CNG-powered vehicles and also estimated from COPERT IV. We estimated emission factors for diesel from surveys on average trip length and fuel consumption. Using IPCC's reference method, we estimate Bogota's total transport-related CO2 emissions for 2008 (reference year) at 4.8 Tg CO2. The disaggregation method estimation is 16% lower, mainly due to uncertainty in activity factors. With only 4% of Bogota's fleet, diesel use accounts for 42% of the CO2 emissions. The emissions are almost evenly shared between public (9% of the fleet) and private transport. Peak emissions occur at 8 a.m. and 6 p.m. with maximum values over a densely industrialized area at the northwest of Bogota. This investigation allowed estimating the relative contribution of fuel and vehicle categories to spatially- and temporally-resolved CO2 emissions. Fuel consumption time series indicate a near-stabilization trend on energy consumption for transportation, which is unexpected taking into account the sustained economic and vehicle fleet growth in Bogota. The comparison of the disaggregation methodology with the IPCC methodology contributes to the analysis of possible error sources on activity factor estimations. This information is very useful for uncertainty estimation and adjustment of primary air pollutant emissions inventories.

  14. 13Check_RNA: A tool to evaluate 13C chemical shifts assignments of RNA.

    PubMed

    Icazatti, A A; Martin, O A; Villegas, M; Szleifer, I; Vila, J A

    2018-06-19

    Chemical shifts (CS) are an important source of structural information of macromolecules such as RNA. In addition to the scarce availability of CS for RNA, the observed values are prone to errors due to a wrong re-calibration or miss assignments. Different groups have dedicated their efforts to correct CS systematic errors on RNA. Despite this, there are not automated and freely available algorithms for correct assignments of RNA 13C CS before their deposition to the BMRB or re-reference already deposited CS with systematic errors. Based on an existent method we have implemented an open source python module to correct 13C CS (from here on 13Cexp) systematic errors of RNAs and then return the results in 3 formats including the nmrstar one. This software is available on GitHub at https://github.com/BIOS-IMASL/13Check_RNA under a MIT license. Supplementary data are available at Bioinformatics online.

  15. 47 CFR 90.627 - Limitation on the number of frequency pairs that may be assignable for trunked systems and on the...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MOBILE RADIO SERVICES Regulations Governing Licensing and Use of Frequencies in the 806-824, 851-869, 896-901, and 935-940 MHz Bands Policies Governing the Processing of Applications and the Selection and... 70 mobile and control stations per channel. [47 FR 41032, Sept. 16, 1982, as amended at 48 FR 44559...

  16. Israeli Ministry of Education's District Managers' and Superintendents' Role as Educational Leaders--Implementing the New Policy for Teachers' Professional Development

    ERIC Educational Resources Information Center

    Avidov-Ungar, Orit; Reingold, Roni

    2018-01-01

    In Israel, the Ministry of Education determines all aspects of educational policy, including teachers' initial teacher education, licensing and professional development. As part of the New Horizon educational reform, the Ministry announced in 2010 a new plan for the professional development of teachers in Israel. The Ministry assigned a mediating…

  17. Spatial accuracy of a simplified disaggregation method for traffic emissions applied in seven mid-sized Chilean cities

    NASA Astrophysics Data System (ADS)

    Ossés de Eicker, Margarita; Zah, Rainer; Triviño, Rubén; Hurni, Hans

    The spatial accuracy of top-down traffic emission inventory maps obtained with a simplified disaggregation method based on street density was assessed in seven mid-sized Chilean cities. Each top-down emission inventory map was compared against a reference, namely a more accurate bottom-up emission inventory map from the same study area. The comparison was carried out using a combination of numerical indicators and visual interpretation. Statistically significant differences were found between the seven cities with regard to the spatial accuracy of their top-down emission inventory maps. In compact cities with a simple street network and a single center, a good accuracy of the spatial distribution of emissions was achieved with correlation values>0.8 with respect to the bottom-up emission inventory of reference. In contrast, the simplified disaggregation method is not suitable for complex cities consisting of interconnected nuclei, resulting in correlation values<0.5. Although top-down disaggregation of traffic emissions generally exhibits low accuracy, the accuracy is significantly higher in compact cities and might be further improved by applying a correction factor for the city center. Therefore, the method can be used by local environmental authorities in cities with limited resources and with little knowledge on the pollution situation to get an overview on the spatial distribution of the emissions generated by traffic activities.

  18. The Science of Salt: A focused review on salt-related knowledge, attitudes and behaviors, and gender differences.

    PubMed

    McKenzie, Briar; Santos, Joseph Alvin; Trieu, Kathy; Thout, Sudhir Raj; Johnson, Claire; Arcand, JoAnne; Webster, Jacqui; McLean, Rachael

    2018-05-01

    The aim of the current review was to examine the scope of studies published in the Science of Salt Weekly that contained a measure of self-reported knowledge, attitudes, and behavior (KAB) concerning salt. Specific objectives were to examine how KAB measures are used to evaluate salt reduction intervention studies, the questionnaires used, and whether any gender differences exist in self-reported KAB. Studies were reviewed from the commencement of Science of Salt Weekly, June 2013 to the end of August 2017. Seventy-five studies had relevant measures of KAB and were included in this review, 13 of these were salt-reduction intervention-evaluation studies, with the remainder (62) being descriptive KAB studies. The KAB questionnaires used were specific to the populations studied, without evidence of a best practice measure. 40% of studies used KAB alone as the primary outcome measure; the remaining studies used more quantitative measures of salt intake such as 24-hour urine. Only half of the descriptive studies showed KAB outcomes disaggregated by gender, and of those, 73% showed women had more favorable KAB related to salt. None of the salt intervention-evaluation studies showed disaggregated KAB data. Therefore, it is likely important that evaluation studies disaggregate, and are appropriately powered to disaggregate all outcomes by gender to address potential disparities. ©2018 Wiley Periodicals, Inc.

  19. Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Jungsoon; Sung, Nuri; Mercado, Jonathan M.

    Hsp104 is a ring-forming protein disaggregase that rescues stress-damaged proteins from an aggregated state. To facilitate protein disaggregation, Hsp104 cooperates with Hsp70 and Hsp40 chaperones (Hsp70/40) to form a bi-chaperone system. How Hsp104 recognizes its substrates, particularly the importance of the N domain, remains poorly understood and multiple, seemingly conficting mechanisms have been proposed. Although the N domain is dispensable for protein disaggregation, it is sensitive to point mutations that abolish the function of the bacterial Hsp104 homolog in vitro, and is essential for curing yeast prions by Hsp104 overexpression in vivo. Here, we present the crystal structure of anmore » N-terminal fragment of Saccharomyces cerevisiae Hsp104 with the N domain of one molecule bound to the C-terminal helix of the neighboring D1 domain. Consistent with mimicking substrate interaction, mutating the putative substrate-binding site in a constitutively active Hsp104 variant impairs the recovery of functional protein from aggregates. We fnd that the observed substrate-binding defect can be rescued by Hsp70/40 chaperones, providing a molecular explanation as to why the N domain is dispensable for protein disaggregation when Hsp70/40 is present, yet essential for the dissolution of Hsp104-specifc substrates, such as yeast prions, which likely depends on a direct N domain interaction.« less

  20. Satellite-Scale Snow Water Equivalent Assimilation into a High-Resolution Land Surface Model

    NASA Technical Reports Server (NTRS)

    De Lannoy, Gabrielle J.M.; Reichle, Rolf H.; Houser, Paul R.; Arsenault, Kristi R.; Verhoest, Niko E.C.; Paulwels, Valentijn R.N.

    2009-01-01

    An ensemble Kalman filter (EnKF) is used in a suite of synthetic experiments to assimilate coarse-scale (25 km) snow water equivalent (SWE) observations (typical of satellite retrievals) into fine-scale (1 km) model simulations. Coarse-scale observations are assimilated directly using an observation operator for mapping between the coarse and fine scales or, alternatively, after disaggregation (re-gridding) to the fine-scale model resolution prior to data assimilation. In either case observations are assimilated either simultaneously or independently for each location. Results indicate that assimilating disaggregated fine-scale observations independently (method 1D-F1) is less efficient than assimilating a collection of neighboring disaggregated observations (method 3D-Fm). Direct assimilation of coarse-scale observations is superior to a priori disaggregation. Independent assimilation of individual coarse-scale observations (method 3D-C1) can bring the overall mean analyzed field close to the truth, but does not necessarily improve estimates of the fine-scale structure. There is a clear benefit to simultaneously assimilating multiple coarse-scale observations (method 3D-Cm) even as the entire domain is observed, indicating that underlying spatial error correlations can be exploited to improve SWE estimates. Method 3D-Cm avoids artificial transitions at the coarse observation pixel boundaries and can reduce the RMSE by 60% when compared to the open loop in this study.

  1. Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation

    DOE PAGES

    Lee, Jungsoon; Sung, Nuri; Mercado, Jonathan M.; ...

    2017-09-11

    Hsp104 is a ring-forming protein disaggregase that rescues stress-damaged proteins from an aggregated state. To facilitate protein disaggregation, Hsp104 cooperates with Hsp70 and Hsp40 chaperones (Hsp70/40) to form a bi-chaperone system. How Hsp104 recognizes its substrates, particularly the importance of the N domain, remains poorly understood and multiple, seemingly conficting mechanisms have been proposed. Although the N domain is dispensable for protein disaggregation, it is sensitive to point mutations that abolish the function of the bacterial Hsp104 homolog in vitro, and is essential for curing yeast prions by Hsp104 overexpression in vivo. Here, we present the crystal structure of anmore » N-terminal fragment of Saccharomyces cerevisiae Hsp104 with the N domain of one molecule bound to the C-terminal helix of the neighboring D1 domain. Consistent with mimicking substrate interaction, mutating the putative substrate-binding site in a constitutively active Hsp104 variant impairs the recovery of functional protein from aggregates. We fnd that the observed substrate-binding defect can be rescued by Hsp70/40 chaperones, providing a molecular explanation as to why the N domain is dispensable for protein disaggregation when Hsp70/40 is present, yet essential for the dissolution of Hsp104-specifc substrates, such as yeast prions, which likely depends on a direct N domain interaction.« less

  2. Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.

    PubMed

    Nichols, Michael R; Moss, Melissa A; Reed, Dana Kim; Cratic-McDaniel, Stephanie; Hoh, Jan H; Rosenberry, Terrone L

    2005-01-28

    The brains of Alzheimer's disease (AD) patients contain large numbers of amyloid plaques that are rich in fibrils composed of 40- and 42-residue amyloid-beta (Abeta) peptides. Several lines of evidence indicate that fibrillar Abeta and especially soluble Abeta aggregates are important in the etiology of AD. Recent reports also stress that amyloid aggregates are polymorphic and that a single polypeptide can fold into multiple amyloid conformations. Here we demonstrate that Abeta-(1-40) can form soluble aggregates with predominant beta-structures that differ in stability and morphology. One class of aggregates involved soluble Abeta protofibrils, prepared by vigorous overnight agitation of monomeric Abeta-(1-40) at low ionic strength. Dilution of these aggregation reactions induced disaggregation to monomers as measured by size exclusion chromatography. Protofibril concentrations monitored by thioflavin T fluorescence decreased in at least two kinetic phases, with initial disaggregation (rate constant approximately 1 h(-1)) followed by a much slower secondary phase. Incubation of the reactions without agitation resulted in less disaggregation at slower rates, indicating that the protofibrils became progressively more stable over time. In fact, protofibrils isolated by size exclusion chromatography were completely stable and gave no disaggregation. A second class of soluble Abeta aggregates was generated rapidly (<10 min) in buffered 2% hexafluoroisopropanol (HFIP). These aggregates showed increased thioflavin T fluorescence and were rich in beta-structure by circular dichroism. Electron microscopy and atomic force microscopy revealed initial globular clusters that progressed over several days to soluble fibrous aggregates. When diluted out of HFIP, these aggregates initially were very unstable and disaggregated completely within 2 min. However, their stability increased as they progressed to fibers. Relative to Abeta protofibrils, the HFIP-induced aggregates seeded elongation by Abeta monomer deposition very poorly. The techniques used to distinguish these two classes of soluble Abeta aggregates may be useful in characterizing Abeta aggregates formed in vivo.

  3. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 05/31/15 3060-0645 Secs. 17.4, 17.48 and 17.49 04/30/15 3060-0647 Cable Price Survey and Supplemental... Licensing of, and Spectrum Usage by, Satellite Network Stations and Space Stations 09/30/13 3060-0685 FCC.../13 3060-0816 FCC 477 04/30/13 3060-0817 Computer III Further Remand Proceedings: BOC Provision of...

  4. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 05/31/15 3060-0645 Secs. 17.4, 17.48 and 17.49 04/30/15 3060-0647 Cable Price Survey and Supplemental... Licensing of, and Spectrum Usage by, Satellite Network Stations and Space Stations 09/30/13 3060-0685 FCC.../13 3060-0816 FCC 477 04/30/13 3060-0817 Computer III Further Remand Proceedings: BOC Provision of...

  5. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 05/31/15 3060-0645 Secs. 17.4, 17.48 and 17.49 04/30/15 3060-0647 Cable Price Survey and Supplemental... Licensing of, and Spectrum Usage by, Satellite Network Stations and Space Stations 09/30/13 3060-0685 FCC.../13 3060-0816 FCC 477 04/30/13 3060-0817 Computer III Further Remand Proceedings: BOC Provision of...

  6. The Relationship of the Officer Evaluation Report to Captain Attrition

    DTIC Science & Technology

    2001-05-31

    especially, Microsoft licensing. The OER plays a significant role in each of these stages, determining or predicting an officer’s potential for career success . The...company command greatly raises expectations for continued career success . Those that have a positive command experience with at least one above center of...system, especially pertaining to branch qualification was reviewed. Nearly 85% had been advised by their branch assignment officer, that future career

  7. α2β1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis

    PubMed Central

    Shield, Kristy; Riley, Clyde; Quinn, Michael A; Rice, Gregory E; Ackland, Margaret L; Ahmed, Nuzhat

    2007-01-01

    Background Ovarian cancer is characterized by a wide-spread intra-abdominal metastases which represents a major clinical hurdle in the prognosis and management of the disease. A significant proportion of ovarian cancer cells in peritoneal ascites exist as multicellular aggregates or spheroids. We hypothesize that these cellular aggregates or spheroids are invasive with the capacity to survive and implant on the peritoneal surface. This study was designed to elucidate early inherent mechanism(s) of spheroid survival, growth and disaggregation required for peritoneal metastases Methods In this study, we determined the growth pattern and adhesive capacity of ovarian cancer cell lines (HEY and OVHS1) grown as spheroids, using the well established liquid overlay technique, and compared them to a normal ovarian cell line (IOSE29) and cancer cells grown as a monolayer. The proteolytic capacity of these spheroids was compared with cells grown as a monolayer using a gelatin zymography assay to analyze secreted MMP-2/9 in conditioned serum-free medium. The disaggregation of cancer cell line spheroids was determined on extracellular matrices (ECM) such as laminin (LM), fibronectin (FN) and collagen (CI) and the expression of α2, α3, αv, α6 and β1 interin was determined by flow cytometric analysis. Neutralizing antibodies against α2, β1 subunits and α2β1 integrin was used to inhibit disaggregation as well as activation of MMPs in spheroids. Results We demonstrate that ovarian cancer cell lines grown as spheroids can sustain growth for 10 days while the normal ovarian cell line failed to grow beyond 2 days. Compared to cells grown as a monolayer, cancer cells grown as spheroids demonstrated no change in adhesion for up to 4 days, while IOSE29 cells had a 2–4-fold loss of adhesion within 2 days. Cancer cell spheroids disaggregated on extracellular matrices (ECM) and demonstrated enhanced expression of secreted pro-MMP2 as well as activated MMP2/MMP9 with no such activation of MMP's observed in monolayer cells. Flow cytometric analysis demonstrated enhanced expression of α2 and diminution of α6 integrin subunits in spheroids versus monolayer cells. No change in the expression of α3, αv and β1 subunits was evident. Conversely, except for αv integrin, a 1.5–7.5-fold decrease in α2, α3, α6 and β1 integrin subunit expression was observed in IOSE29 cells within 2 days. Neutralizing antibodies against α2, β1 subunits and α2β1 integrin inhibited disaggregation as well as activation of MMPs in spheroids. Conclusion Our results suggest that enhanced expression of α2β1 integrin may influence spheroid disaggregation and proteolysis responsible for the peritoneal dissemination of ovarian carcinoma. This may indicate a new therapeutic target for the suppression of the peritoneal metastasis associated with advanced ovarian carcinomas. PMID:17567918

  8. Disaggregation of small, cohesive rubble pile asteroids due to YORP

    NASA Astrophysics Data System (ADS)

    Scheeres, D. J.

    2018-04-01

    The implication of small amounts of cohesion within relatively small rubble pile asteroids is investigated with regard to their evolution under the persistent presence of the YORP effect. We find that below a characteristic size, which is a function of cohesive strength, density and other properties, rubble pile asteroids can enter a "disaggregation phase" in which they are subject to repeated fissions after which the formation of a stabilizing binary system is not possible. Once this threshold is passed rubble pile asteroids may be disaggregated into their constituent components within a finite time span. These constituent components will have their own spin limits - albeit potentially at a much higher spin rate due to the greater strength of a monolithic body. The implications of this prediction are discussed and include modification of size distributions, prevalence of monolithic bodies among meteoroids and the lifetime of small rubble pile bodies in the solar system. The theory is then used to place constraints on the strength of binary asteroids characterized as a function of their type.

  9. Dynamic structural states of ClpB involved in its disaggregation function.

    PubMed

    Uchihashi, Takayuki; Watanabe, Yo-Hei; Nakazaki, Yosuke; Yamasaki, Takashi; Watanabe, Hiroki; Maruno, Takahiro; Ishii, Kentaro; Uchiyama, Susumu; Song, Chihong; Murata, Kazuyoshi; Iino, Ryota; Ando, Toshio

    2018-06-01

    The ATP-dependent bacterial protein disaggregation machine, ClpB belonging to the AAA+ superfamily, refolds toxic protein aggregates into the native state in cooperation with the cognate Hsp70 partner. The ring-shaped hexamers of ClpB unfold and thread its protein substrate through the central pore. However, their function-related structural dynamics has remained elusive. Here we directly visualize ClpB using high-speed atomic force microscopy (HS-AFM) to gain a mechanistic insight into its disaggregation function. The HS-AFM movies demonstrate massive conformational changes of the hexameric ring during ATP hydrolysis, from a round ring to a spiral and even to a pair of twisted half-spirals. HS-AFM observations of Walker-motif mutants unveil crucial roles of ATP binding and hydrolysis in the oligomer formation and structural dynamics. Furthermore, repressed and hyperactive mutations result in significantly different oligomeric forms. These results provide a comprehensive view for the ATP-driven oligomeric-state transitions that enable ClpB to disentangle protein aggregates.

  10. Energy prediction using spatiotemporal pattern networks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jiang, Zhanhong; Liu, Chao; Akintayo, Adedotun

    This paper presents a novel data-driven technique based on the spatiotemporal pattern network (STPN) for energy/power prediction for complex dynamical systems. Built on symbolic dynamical filtering, the STPN framework is used to capture not only the individual system characteristics but also the pair-wise causal dependencies among different sub-systems. To quantify causal dependencies, a mutual information based metric is presented and an energy prediction approach is subsequently proposed based on the STPN framework. To validate the proposed scheme, two case studies are presented, one involving wind turbine power prediction (supply side energy) using the Western Wind Integration data set generated bymore » the National Renewable Energy Laboratory (NREL) for identifying spatiotemporal characteristics, and the other, residential electric energy disaggregation (demand side energy) using the Building America 2010 data set from NREL for exploring temporal features. In the energy disaggregation context, convex programming techniques beyond the STPN framework are developed and applied to achieve improved disaggregation performance.« less

  11. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.

    PubMed

    Rampelt, Heike; Kirstein-Miles, Janine; Nillegoda, Nadinath B; Chi, Kang; Scholz, Sebastian R; Morimoto, Richard I; Bukau, Bernd

    2012-11-05

    Accumulation of aggregation-prone misfolded proteins disrupts normal cellular function and promotes ageing and disease. Bacteria, fungi and plants counteract this by solubilizing and refolding aggregated proteins via a powerful cytosolic ATP-dependent bichaperone system, comprising the AAA+ disaggregase Hsp100 and the Hsp70-Hsp40 system. Metazoa, however, lack Hsp100 disaggregases. We show that instead the Hsp110 member of the Hsp70 superfamily remodels the human Hsp70-Hsp40 system to efficiently disaggregate and refold aggregates of heat and chemically denatured proteins in vitro and in cell extracts. This Hsp110 effect relies on nucleotide exchange, not on ATPase activity, implying ATP-driven chaperoning is not required. Knock-down of nematode Caenorhabditis elegans Hsp110, but not an unrelated nucleotide exchange factor, compromises dissolution of heat-induced protein aggregates and severely shortens lifespan after heat shock. We conclude that in metazoa, Hsp70-Hsp40 powered by Hsp110 nucleotide exchange represents the crucial disaggregation machinery that reestablishes protein homeostasis to counteract protein unfolding stress.

  12. Economic growth, energy consumption and CO2 emissions in India: a disaggregated causal analysis

    NASA Astrophysics Data System (ADS)

    Nain, Md Zulquar; Ahmad, Wasim; Kamaiah, Bandi

    2017-09-01

    This study examines the long-run and short-run causal relationships among energy consumption, real gross domestic product (GDP) and CO2 emissions using aggregate and disaggregate (sectoral) energy consumption measures utilising annual data from 1971 to 2011. The autoregressive distributed lag bounds test reveals that there is a long-run relationship among the variables concerned at both aggregate and disaggregate levels. The Toda-Yamamoto causality tests, however, reveal that the long-run as well short-run causal relationship among the variables is not uniform across sectors. The weight of evidences of the study indicates that there is short-run causality from electricity consumption to economic growth, and to CO2 emissions. The results suggest that India should take appropriate cautious steps to sustain high growth rate and at the same time to control emissions of CO2. Further, energy and environmental policies should acknowledge the sectoral differences in the relationship between energy consumption and real gross domestic product.

  13. Disaggregation of lipopolysaccharide by albumin, hemoglobin or high-density lipoprotein, forming complexes that prime neutrophils for enhanced release of superoxide.

    PubMed

    Komatsu, Toshiya; Aida, Yoshitomi; Fukuda, Takao; Sanui, Terukazu; Hiratsuka, Shunji; Pabst, Michael J; Nishimura, Fusanori

    2016-04-01

    We studied the interaction of LPS with albumin, hemoglobin or high-density lipoprotein (HDL), and whether the interaction affected the activity of LPS on neutrophils. These proteins disaggregated LPS, depending upon temperature and LPS:protein ratio. Albumin-treated LPS was absorbed by immobilized anti-albumin antibody and was eluted with Triton X-100, indicating that LPS formed a hydrophobic complex with albumin. Rd mutant LPS was not disaggregated by the proteins, and did not form a complex with the proteins. But triethylamine-treated Rd mutant LPS formed complexes. When LPS was incubated with an equal concentration of albumin and with polymyxin B (PMXB), PMXB-LPS-protein three-way complexes were formed. After removal of PMXB, the complexes consisted of 11-15 LPS monomers bound to one albumin or hemoglobin molecule. LPS primed neutrophils for enhanced release of formyl peptide-stimulated superoxide, in a serum- and LPS-binding protein (LBP)-dependent manner. Although LPS plus LBP alone did not prime neutrophils, albumin-, hemoglobin- or HDL-treated LPS primed neutrophils when added with LBP. Triethylamine-treated Rd mutant LPS primed neutrophils only when incubated with one of the proteins and with LBP. Thus, in addition to LBP, disaggregation and complex formation of LPS with one of these proteins is required for LPS to prime neutrophils. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. An Optimization of the Basic School Military Occupational Skill Assignment Process

    DTIC Science & Technology

    2003-06-01

    Corps Intranet (NMCI)23 supports it. We evaluated the use of Microsoft’s SQL Server, but dismissed this after learning that TBS did not possess a SQL ...Server license or a qualified SQL Server administrator.24 SQL Server would have provided for additional security measures not available in MS...administrator. Although not has powerful as SQL Server, MS Access can handle the multi-user environment necessary for this system.25 The training

  15. Preceptor Support in Hospital Transition to Practice Programs.

    PubMed

    Blegen, Mary A; Spector, Nancy; Ulrich, Beth T; Lynn, Mary R; Barnsteiner, Jane; Silvestre, Josephine

    2015-12-01

    The aim of this study was to describe newly licensed RN (NLRN) preceptorships and the effects on competency and retention. Preceptors are widely used, but little is known about the benefit from the perspective of the NLRN or about the models of the relationships. The National Council of State Boards of Nursing added questions about the preceptor experience in a study of transition-to-practice programs. Hospitals were coded as having high or low preceptor support in regard to scheduling NLRN on the same shifts as their preceptors, assignment sharing, and preceptor release time and a low number of preceptors per preceptee. Half of the 82 hospitals were classified as high, and half as low preceptor support. NLRNs and their preceptors in high-support hospitals evaluated the preceptor experience and NLRN competence higher. In addition, NLRN retention was higher in the high-support hospitals. To improve NLRN competence and retention, preceptors should have adequate time with each NLRN, share shift and patient assignments, and have few preceptees assigned to each preceptor concurrently.

  16. Aggregation and Disaggregation of Senile Plaques in Alzheimer Disease

    NASA Astrophysics Data System (ADS)

    Cruz, L.; Urbanc, B.; Buldyrev, S. V.; Christie, R.; Gomez-Isla, T.; Havlin, S.; McNamara, M.; Stanley, H. E.; Hyman, B. T.

    1997-07-01

    We quantitatively analyzed, using laser scanning confocal microscopy, the three-dimensional structure of individual senile plaques in Alzheimer disease. We carried out the quantitative analysis using statistical methods to gain insights about the processes that govern Aβ peptide deposition. Our results show that plaques are complex porous structures with characteristic pore sizes. We interpret plaque morphology in the context of a new dynamical model based on competing aggregation and disaggregation processes in kinetic steady-state equilibrium with an additional diffusion process allowing Aβ deposits to diffuse over the surface of plaques.

  17. Disaggregation Of Passive Microwave Soil Moisture For Use In Watershed Hydrology Applications

    NASA Astrophysics Data System (ADS)

    Fang, Bin

    In recent years the passive microwave remote sensing has been providing soil moisture products using instruments on board satellite/airborne platforms. Spatial resolution has been restricted by the diameter of antenna which is inversely proportional to resolution. As a result, typical products have a spatial resolution of tens of kilometers, which is not compatible for some hydrological research applications. For this reason, the dissertation explores three disaggregation algorithms that estimate L-band passive microwave soil moisture at the subpixel level by using high spatial resolution remote sensing products from other optical and radar instruments were proposed and implemented in this investigation. The first technique utilized a thermal inertia theory to establish a relationship between daily temperature change and average soil moisture modulated by the vegetation condition was developed by using NLDAS, AVHRR, SPOT and MODIS data were applied to disaggregate the 25 km AMSR-E soil moisture to 1 km in Oklahoma. The second algorithm was built on semi empirical physical models (NP89 and LP92) derived from numerical experiments between soil evaporation efficiency and soil moisture over the surface skin sensing depth (a few millimeters) by using simulated soil temperature derived from MODIS and NLDAS as well as AMSR-E soil moisture at 25 km to disaggregate the coarse resolution soil moisture to 1 km in Oklahoma. The third algorithm modeled the relationship between the change in co-polarized radar backscatter and the remotely sensed microwave change in soil moisture retrievals and assumed that change in soil moisture was a function of only the canopy opacity. The change detection algorithm was implemented using aircraft based the remote sensing data from PALS and UAVSAR that were collected in SMPAVEX12 in southern Manitoba, Canada. The PALS L-band h-polarization radiometer soil moisture retrievals were disaggregated by combining them with the PALS and UAVSAR L-band hh-polarization radar spatial resolutions of 1500 m and 5 m/800 m, respectively. All three algorithms were validated using ground measurements from network in situ stations or handheld hydra probes. The validation results demonstrate the practicability on coarse resolution passive microwave soil moisture products.

  18. Complex life cycles in a pond food web: effects of life stage structure and parasites on network properties, trophic positions and the fit of a probabilistic niche model.

    PubMed

    Preston, Daniel L; Jacobs, Abigail Z; Orlofske, Sarah A; Johnson, Pieter T J

    2014-03-01

    Most food webs use taxonomic or trophic species as building blocks, thereby collapsing variability in feeding linkages that occurs during the growth and development of individuals. This issue is particularly relevant to integrating parasites into food webs because parasites often undergo extreme ontogenetic niche shifts. Here, we used three versions of a freshwater pond food web with varying levels of node resolution (from taxonomic species to life stages) to examine how complex life cycles and parasites alter web properties, the perceived trophic position of organisms, and the fit of a probabilistic niche model. Consistent with prior studies, parasites increased most measures of web complexity in the taxonomic species web; however, when nodes were disaggregated into life stages, the effects of parasites on several network properties (e.g., connectance and nestedness) were reversed, due in part to the lower trophic generality of parasite life stages relative to free-living life stages. Disaggregation also reduced the trophic level of organisms with either complex or direct life cycles and was particularly useful when including predation on parasites, which can inflate trophic positions when life stages are collapsed. Contrary to predictions, disaggregation decreased network intervality and did not enhance the fit of a probabilistic niche model to the food webs with parasites. Although the most useful level of biological organization in food webs will vary with the questions of interest, our results suggest that disaggregating species-level nodes may refine our perception of how parasites and other complex life cycle organisms influence ecological networks.

  19. Aggregation and disaggregation kinetics of human blood platelets: Part II. Shear-induced platelet aggregation.

    PubMed Central

    Huang, P Y; Hellums, J D

    1993-01-01

    A population balance equation (PBE) mathematical model for analyzing platelet aggregation kinetics was developed in Part I (Huang, P. Y., and J. D. Hellums. 1993. Biophys. J. 65: 334-343) of a set of three papers. In this paper, Part II, platelet aggregation and related reactions are studied in the uniform, known shear stress field of a rotational viscometer, and interpreted by means of the model. Experimental determinations are made of the platelet-aggregate particle size distributions as they evolve in time under the aggregating influence of shear stress. The PBE model is shown to give good agreement with experimental determinations when either a reversible (aggregation and disaggregation) or an irreversible (no disaggregation) form of the model is used. This finding suggests that for the experimental conditions studied disaggregation processes are of only secondary importance. During shear-induced platelet aggregation, only a small fraction of platelet collisions result in the binding together of the involved platelets. The modified collision efficiency is approximately zero for shear rates below 3000 s-1. It increases with shear rates above 3000 s-1 to about 0.01 for a shear rate of 8000 s-1. Addition of platelet chemical agonists yields order of magnitude increases in collision efficiency. The collision efficiency for shear-induced platelet aggregation is about an order of magnitude less at 37 degrees C than at 24 degrees C. The PBE model gives a much more accurate representation of aggregation kinetics than an earlier model based on a monodispersed particle size distribution. PMID:8369442

  20. Prelicensure Employment and Student Nurse Self-Efficacy.

    PubMed

    Grimm, Khristina L

    There is a lack of literature regarding how prelicensure employment affects self-efficacy in nursing practice. The purpose of this study was to examine the relationship among prelicensure employment and self-efficacy in nursing practice of senior student nurses. Healthcare experience was identified as the best predictor of positive self-efficacy in managing an assignment of three and four patients. Findings of this study provide insight for providing orientation for newly licensed nurses regarding their readiness to practice.

  1. Research Monograph on Federal International Economic Emergency Planning.

    DTIC Science & Technology

    1985-10-31

    interrelates national and international factors in world food supply. 1 1 1 I I I I I -3- 1 I.B. PARAMETERS OF THIS STUDY Assigning a scope to a study...of their specialization. Thus "air" is typically 3 considered a limitless resource, and therefore a non-economic good, whereas food , clothing and...rights to use such information in the form of licenses, patents, franchises , etc. I Accordingly, for purposes of this study, we shall define economics

  2. An Alternative Approach to the Operation of Multinational Reservoir Systems: Application to the Amistad & Falcon System (Lower Rio Grande/Rí-o Bravo)

    NASA Astrophysics Data System (ADS)

    Serrat-Capdevila, A.; Valdes, J. B.

    2005-12-01

    An optimization approach for the operation of international multi-reservoir systems is presented. The approach uses Stochastic Dynamic Programming (SDP) algorithms, both steady-state and real-time, to develop two models. In the first model, the reservoirs and flows of the system are aggregated to yield an equivalent reservoir, and the obtained operating policies are disaggregated using a non-linear optimization procedure for each reservoir and for each nation water balance. In the second model a multi-reservoir approach is applied, disaggregating the releases for each country water share in each reservoir. The non-linear disaggregation algorithm uses SDP-derived operating policies as boundary conditions for a local time-step optimization. Finally, the performance of the different approaches and methods is compared. These models are applied to the Amistad-Falcon International Reservoir System as part of a binational dynamic modeling effort to develop a decision support system tool for a better management of the water resources in the Lower Rio Grande Basin, currently enduring a severe drought.

  3. Regional differences in usage of antenatal care and safe delivery services in Indonesia: findings from a nationally representative survey.

    PubMed

    Tripathi, Vrijesh; Singh, Rajvir

    2017-02-03

    Indonesia has shown a nominal increase in antenatal care (ANC) coverage from 93% to 96% in the Indonesia Demographic Health Survey (IDHS)-2012. This is high but for a comprehensive assessment of maternal health coverage in Indonesia, safe delivery services need to be assessed in conjunction with ANC coverage. The study uses survey data from the IDHS-2012 that was conducted among women aged 15-49 years who gave birth during the past 3 years preceding the survey. Socioeconomic and demographic factors affecting ANC coverage and safe delivery services are analysed by segregating the data into 7 regions of Indonesia. Multivariate results show that besides wealth and education differentials, regional differences significantly affect the usage of ANC and safe delivery services across the 7 regions. Univariate analyses show that Sulawesi, Maluku and Western New Guinea islands are at a disadvantage in accessing ANC and safe delivery services. The study recommends that disaggregated regional targets be set in order to further reduce maternal mortality rates in Indonesia. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  4. Occupational exposures and chronic obstructive pulmonary disease (COPD): comparison of a COPD-specific job exposure matrix and expert-evaluated occupational exposures.

    PubMed

    Kurth, Laura; Doney, Brent; Weinmann, Sheila

    2017-03-01

    To compare the occupational exposure levels assigned by our National Institute for Occupational Safety and Health chronic obstructive pulmonary disease-specific job exposure matrix (NIOSH COPD JEM) and by expert evaluation of detailed occupational information for various jobs held by members of an integrated health plan in the Northwest USA. We analysed data from a prior study examining COPD and occupational exposures. Jobs were assigned exposure levels using 2 methods: (1) the COPD JEM and (2) expert evaluation. Agreement (Cohen's κ coefficients), sensitivity and specificity were calculated to compare exposure levels assigned by the 2 methods for 8 exposure categories. κ indicated slight to moderate agreement (0.19-0.51) between the 2 methods and was highest for organic dust and overall exposure. Sensitivity of the matrix ranged from 33.9% to 68.5% and was highest for sensitisers, diesel exhaust and overall exposure. Specificity ranged from 74.7% to 97.1% and was highest for fumes, organic dust and mineral dust. This COPD JEM was compared with exposures assigned by experts and offers a generalisable approach to assigning occupational exposure. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  5. Planning and Implementing a Hospital Recycling Program at Naval Hospital, Camp Pendleton, California

    DTIC Science & Technology

    1992-08-01

    communities have refused to license incinerators, saying "not in my back yard!" Recycling is quick, it’s economical, it can save natural resources, and...total costs - total credits) 4. Net Savings <Costs>: Present disposal Net recycling Net savings costs program costs <costs> * Assign only a...RECYCLING PROGRAM COSTS $ 9,739 (total costs - total credits) 4. Net Savings <Costs>: $ 9.287 _ $ 9.739 - S > Present disposal Net recycling Net

  6. Destabilization of Human Insulin Fibrils by Peptides of Fruit Bromelain Derived From Ananas comosus (Pineapple).

    PubMed

    Das, Sromona; Bhattacharyya, Debasish

    2017-12-01

    Deposition of insulin aggregates in human body leads to dysfunctioning of several organs. Effectiveness of fruit bromelain from pineapple in prevention of insulin aggregate was investigated. Proteolyses of bromelain was done as par human digestive system and the pool of small peptides was separated from larger peptides and proteins. Under conditions of growth of insulin aggregates from its monomers, this pool of peptides restricted the reaction upto formation of oligomers of limited size. These peptides also destabilized preformed insulin aggregates to oligomers. These processes were followed fluorimetrically using Thioflavin T and 1-ANS, size-exclusion HPLC, dynamic light scattering, atomic force microscopy, and transmission electron microscopy. Sequences of insulin (A and B chains) and bromelain were aligned using Clustal W software to predict most probable sites of interactions. Synthetic tripeptides corresponding to the hydrophobic interactive sites of bromelain showed disaggregation of insulin suggesting specificity of interactions. The peptides GG and AAA serving as negative controls showed no potency in destabilization of aggregates. Disaggregation potency of the peptides was also observed when insulin was deposited on HepG2 liver cells where no formation of toxic oligomers occurred. Amyloidogenic des-octapeptide (B23-B30 of insulin) incapable of cell signaling showed cytotoxicity similar to insulin. This toxicity could be neutralized by bromelain derived peptides. FT-IR and far-UV circular dichroism analysis indicated that disaggregated insulin had structure distinctly different from that of its hexameric (native) or monomeric states. Based on the stoichiometry of interaction and irreversibility of disaggregation, the mechanism/s of the peptides and insulin interactions has been proposed. J. Cell. Biochem. 118: 4881-4896, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  7. Estimation of Actual Crop ET of Paddy Using the Energy Balance Model SMARET and Validation with Field Water Balance Measurements and a Crop Growth Model (ORYZA)

    NASA Astrophysics Data System (ADS)

    Nallasamy, N. D.; Muraleedharan, B. V.; Kathirvel, K.; Narasimhan, B.

    2014-12-01

    Sustainable management of water resources requires reliable estimates of actual evapotranspiration (ET) at fine spatial and temporal resolution. This is significant in the case of rice based irrigation systems, one of the major consumers of surface water resources and where ET forms a major component of water consumption. However huge tradeoff in the spatial and temporal resolution of satellite images coupled with lack of adequate number of cloud free images within a growing season act as major constraints in deriving ET at fine spatial and temporal resolution using remote sensing based energy balance models. The scale at which ET is determined is decided by the spatial and temporal scale of Land Surface Temperature (LST) and Normalized Difference Vegetation Index (NDVI), which form inputs to energy balance models. In this context, the current study employed disaggregation algorithms (NL-DisTrad and DisNDVI) to generate time series of LST and NDVI images at fine resolution. The disaggregation algorithms aimed at generating LST and NDVI at finer scale by integrating temporal information from concurrent coarse resolution data and spatial information from a single fine resolution image. The temporal frequency of the disaggregated images is further improved by employing composite images of NDVI and LST in the spatio-temporal disaggregation method. The study further employed half-hourly incoming surface insolation and outgoing long wave radiation obtained from the Indian geostationary satellite (Kalpana-1) to convert the instantaneous ET into daily ET and subsequently to the seasonal ET, thereby improving the accuracy of ET estimates. The estimates of ET were validated with field based water balance measurements carried out in Gadana, a subbasin predominated by rice paddy fields, located in Tamil Nadu, India.

  8. Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes

    PubMed Central

    Murray, Amber N; Palhano, Fernando L; Bieschke, Jan; Kelly, Jeffery W

    2013-01-01

    The accumulation of cross-β-sheet amyloid fibrils is the hallmark of amyloid diseases. Recently, we reported the discovery of amyloid disaggregase activities in extracts from mammalian cells and Caenorhabditis elegans. However, we have discovered a problem with the interpretation of our previous results as Aβ disaggregation in vitro. Here, we show that Aβ fibrils adsorb to the plastic surface of multiwell plates and Eppendorf tubes. This adsorption is markedly increased in the presence of complex biological mixtures subjected to a denaturing air-water interface. The time-dependent loss of thioflavin T fluorescence that we interpreted previously as disaggregation is due to increased adsorption of Aβ amyloid to the surfaces of multiwell plates and Eppendorf tubes in the presence of biological extracts. As the proteins in biological extracts denature over time at the air-water interface due to agitation/shaking, their adsorption increases, in turn promoting adsorption of amyloid fibrils. We delineate important control experiments that quantify the extent of amyloid adsorption to the surface of plastic and quartz containers. Based on the results described in this article, we conclude that our interpretation of the kinetic fibril disaggregation assay data previously reported in Bieschke et al., Protein Sci 2009;18:2231–2241 and Murray et al., Protein Sci 2010;19:836–846 is invalid when used as evidence for a disaggregase activity. Thus, we correct the two prior publications reporting that worm or mammalian cell extracts disaggregate Aβ amyloid fibrils in vitro at 37°C (see Corrigenda in this issue of Protein Science). We apologize for misinterpreting our previous data and for any confounding experimental efforts this may have caused. PMID:23963844

  9. Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes.

    PubMed

    Murray, Amber N; Palhano, Fernando L; Bieschke, Jan; Kelly, Jeffery W

    2013-11-01

    The accumulation of cross-β-sheet amyloid fibrils is the hallmark of amyloid diseases. Recently, we reported the discovery of amyloid disaggregase activities in extracts from mammalian cells and Caenorhabditis elegans. However, we have discovered a problem with the interpretation of our previous results as Aβ disaggregation in vitro. Here, we show that Aβ fibrils adsorb to the plastic surface of multiwell plates and Eppendorf tubes. This adsorption is markedly increased in the presence of complex biological mixtures subjected to a denaturing air-water interface. The time-dependent loss of thioflavin T fluorescence that we interpreted previously as disaggregation is due to increased adsorption of Aβ amyloid to the surfaces of multiwell plates and Eppendorf tubes in the presence of biological extracts. As the proteins in biological extracts denature over time at the air-water interface due to agitation/shaking, their adsorption increases, in turn promoting adsorption of amyloid fibrils. We delineate important control experiments that quantify the extent of amyloid adsorption to the surface of plastic and quartz containers. Based on the results described in this article, we conclude that our interpretation of the kinetic fibril disaggregation assay data previously reported in Bieschke et al., Protein Sci 2009;18:2231-2241 and Murray et al., Protein Sci 2010;19:836-846 is invalid when used as evidence for a disaggregase activity. Thus, we correct the two prior publications reporting that worm or mammalian cell extracts disaggregate Aβ amyloid fibrils in vitro at 37°C (see Corrigenda in this issue of Protein Science). We apologize for misinterpreting our previous data and for any confounding experimental efforts this may have caused. © 2013 The Protein Society.

  10. A complex magma mixing origin for rocks erupted in 1915, Lassen Peak, California

    USGS Publications Warehouse

    Clynne, M.A.

    1999-01-01

    The eruption of Lassen Peak in May 1915 produced four volcanic rock types within 3 days, and in the following order: (1) hybrid black dacite lava containing (2) undercooled andesitic inclusions, (3) compositionally banded pumice with dark andesite and light dacite bands, and (4) unbanded light dacite. All types represent stages of a complex mixing process between basaltic andesite and dacite that was interrupted by the eruption. They contain disequilibrium phenocryst assemblages characterized by the co-existence of magnesian olivine and quartz and by reacted and unreacted phenocrysts derived from the dacite. The petrography and crystal chemistry of the phenocrysts and the variation in rock compositions indicate that basaltic andesite intruded dacite magma and partially hybridized with it. Phenocrysts from the dacite magma were reacted. Cooling, cyrstallization, and vesiculation of the hybrid andesite magma converted it to a layer of mafic foam. The decreased density of the andesite magma destabilized and disrupted the foam. Blobs of foam rose into and were further cooled by the overlying dacite magma, forming the andesitic inclusions. Disaggregation of andesitic inclusions in the host dacite produced the black dacite and light dacite magmas. Formation of foam was a dynamic process. Removal of foam propagated the foam layer downward into the hybrid andesite magma. Eventually the thermal and compositional contrasts between the hybrid andesite and black dacite magmas were reduced. Then, they mixed directly, forming the dark andesite magma. About 40-50% andesitic inclusions were disaggregated into the host dacite to produce the hybrid black dacite. Thus, disaggregation of inclusions into small fragments and individual crystals can be an efficient magma-mixing process. Disaggregation of undercooled inclusions carrying reacted host-magma phenocrysts produces co-existing reacted and unreacted phenocrysts populations.

  11. Development of a transplantable glioma tumour model from genetically engineered mice: MRI/MRS/MRSI characterisation.

    PubMed

    Ciezka, Magdalena; Acosta, Milena; Herranz, Cristina; Canals, Josep M; Pumarola, Martí; Candiota, Ana Paula; Arús, Carles

    2016-08-01

    The initial aim of this study was to generate a transplantable glial tumour model of low-intermediate grade by disaggregation of a spontaneous tumour mass from genetically engineered models (GEM). This should result in an increased tumour incidence in comparison to GEM animals. An anaplastic oligoastrocytoma (OA) tumour of World Health Organization (WHO) grade III was obtained from a female GEM mouse with the S100β-v-erbB/inK4a-Arf (+/-) genotype maintained in the C57BL/6 background. The tumour tissue was disaggregated; tumour cells from it were grown in aggregates and stereotactically injected into C57BL/6 mice. Tumour development was followed using Magnetic Resonance Imaging (MRI), while changes in the metabolomics pattern of the masses were evaluated by Magnetic Resonance Spectroscopy/Spectroscopic Imaging (MRS/MRSI). Final tumour grade was evaluated by histopathological analysis. The total number of tumours generated from GEM cells from disaggregated tumour (CDT) was 67 with up to 100 % penetrance, as compared to 16 % in the local GEM model, with an average survival time of 66 ± 55 days, up to 4.3-fold significantly higher than the standard GL261 glioblastoma (GBM) tumour model. Tumours produced by transplantation of cells freshly obtained from disaggregated GEM tumour were diagnosed as WHO grade III anaplastic oligodendroglioma (ODG) and OA, while tumours produced from a previously frozen sample were diagnosed as WHO grade IV GBM. We successfully grew CDT and generated tumours from a grade III GEM glial tumour. Freezing and cell culture protocols produced progression to grade IV GBM, which makes the developed transplantable model qualify as potential secondary GBM model in mice.

  12. Decomposition of Sources of Errors in Seasonal Streamflow Forecasting over the U.S. Sunbelt

    NASA Technical Reports Server (NTRS)

    Mazrooei, Amirhossein; Sinah, Tusshar; Sankarasubramanian, A.; Kumar, Sujay V.; Peters-Lidard, Christa D.

    2015-01-01

    Seasonal streamflow forecasts, contingent on climate information, can be utilized to ensure water supply for multiple uses including municipal demands, hydroelectric power generation, and for planning agricultural operations. However, uncertainties in the streamflow forecasts pose significant challenges in their utilization in real-time operations. In this study, we systematically decompose various sources of errors in developing seasonal streamflow forecasts from two Land Surface Models (LSMs) (Noah3.2 and CLM2), which are forced with downscaled and disaggregated climate forecasts. In particular, the study quantifies the relative contributions of the sources of errors from LSMs, climate forecasts, and downscaling/disaggregation techniques in developing seasonal streamflow forecast. For this purpose, three month ahead seasonal precipitation forecasts from the ECHAM4.5 general circulation model (GCM) were statistically downscaled from 2.8deg to 1/8deg spatial resolution using principal component regression (PCR) and then temporally disaggregated from monthly to daily time step using kernel-nearest neighbor (K-NN) approach. For other climatic forcings, excluding precipitation, we considered the North American Land Data Assimilation System version 2 (NLDAS-2) hourly climatology over the years 1979 to 2010. Then the selected LSMs were forced with precipitation forecasts and NLDAS-2 hourly climatology to develop retrospective seasonal streamflow forecasts over a period of 20 years (1991-2010). Finally, the performance of LSMs in forecasting streamflow under different schemes was analyzed to quantify the relative contribution of various sources of errors in developing seasonal streamflow forecast. Our results indicate that the most dominant source of errors during winter and fall seasons is the errors due to ECHAM4.5 precipitation forecasts, while temporal disaggregation scheme contributes to maximum errors during summer season.

  13. Meat consumption after disaggregation of meat dishes in a cohort of British adults in 1989 and 1999 in relation to diet quality.

    PubMed

    Prynne, C J; Wagemakers, J J M F; Stephen, A M; Wadsworth, M E J

    2009-05-01

    The aim of the study was to quantify more precisely the meat intake of a cohort of adults in the UK by disaggregating composite meat dishes. Subjects were members of the Medical Research Council National Survey of Health and Development, 1946 birth cohort. Five-day diaries were collected from 2256 men and women in 1989 and 1772 men and women in 1999. From the details provided, composite meat dishes were broken down into their constituent parts and the meat fraction was added to meat portions only. Meat intake was classified as red meat, processed meat and poultry. Meat consumption without disaggregation of meat dishes resulted in a mean overestimation of 50% in men and 33% in women. Red meat consumption fell between 1989 and 1999 from 51.7 to 41.5 g per day in men and 35.7 to 30.1 g per day in women. Poultry consumption rose from 21.6 to 32.2 g per day in men and 18.2 to 29.4 g per day in women. Re-calculating red meat intakes resulted in the percentage of subjects in 1999 consuming more than the recommendation of the World Cancer Research Fund falling from 30 to 12%. Increasing consumption of red and processed meat was associated with increased intakes of energy, fat, haem iron, zinc and vitamin B(12), and lower intake of fibre. Increased sodium intake was associated with increased consumption of processed meat. Disaggregation of meat dishes provided a more precise estimate of meat consumption. The quantity of red or processed meat in the diet was reflected in the nutrient content of the entire diet.

  14. Meat consumption after disaggregation of meat dishes in a cohort of British adults in 1989 and 1999 in relation to diet quality

    PubMed Central

    Prynne, Celia J.; Wagemakers, Jessie J.M.F.; Stephen, Alison M.; Wadsworth, Michael E.J.

    2009-01-01

    Objectives The aim of the study was to quantify more precisely the meat intake of a cohort of adults in the UK by disaggregating composite meat dishes. Subjects/Methods Subjects were members of the MRC National Survey of Health and Development, 1946 birth cohort. Five-day diaries were collected from 2256 men and women in 1989 and 1772 men and women in 1999. From the details provided, composite meat dishes were broken down into their constituent parts and the meat fraction added to meat only portions. Meat intake was classified as red meat, processed meat and poultry. Results Meat consumption without disaggregation of meat dishes resulted in a mean over-estimation of 50% in men and 33% in women. Red meat consumption fell between 1989 and 1999 from 51.7 to 41.5g/day in men and 35.7 to 30.1g/day in women. Poultry consumption rose from 21.6 to 32.2g./day in men and 18.2 to 29.4 g/day in women. Re-calculating red meat intakes resulted in the percentage of subjects in 1999 consuming more the recommendation of the World Cancer Research Fund falling from 30% to 12 %. Increasing consumption of red and processed meat was associated with increased intakes of energy, fat, haem iron, zinc and vitamin B12 and lower intake of fibre. Increased sodium intake was associated with increased consumption of processed meat. Conclusions Disaggregation of meat dishes provided a more precise estimate of meat consumption. The quantity of red or processed meat in the diet was reflected in the nutrient content of the entire diet. PMID:18285805

  15. Western municipal water conservation policy: The case of disaggregated demand

    NASA Astrophysics Data System (ADS)

    Burness, Stuart; Chermak, Janie; Krause, Kate

    2005-03-01

    We investigate aspects of the felicity of both incentive-based and command and control policies in effecting municipal water conservation goals. When demand can be disaggregated according to uses or users, our results suggest that policy efforts be focused on the submarket wherein demand is more elastic. Under plausible consumer parameters, a household production function approach to water utilization prescribes the nature of demand elasticities in alternative uses and squares nicely with empirical results from the literature. An empirical example illustrates. Overall, given data and other informational limitations, extant institutional structures, and in situ technology, our analysis suggests a predisposition for command and control policies over incentive-based tools.

  16. Relative health effects of education, socioeconomic status and domestic gender inequity in Sweden: a cohort study.

    PubMed

    Phillips, Susan P; Hammarström, Anne

    2011-01-01

    Limited existing research on gender inequities suggests that for men workplace atmosphere shapes wellbeing while women are less susceptible to socioeconomic or work status but vulnerable to home inequities. Using the 2007 Northern Swedish Cohort (n = 773) we identified relative contributions of perceived gender inequities in relationships, financial strain, and education to self-reported health to determine whether controlling for sex, examining interactions between sex and other social variables, or sex-disaggregating data yielded most information about sex differences. Men had lower education but also less financial strain, and experienced less gender inequity. Overall, low education and financial strain detracted from health. However, sex-disaggregated data showed this to be true for women, whereas for men only gender inequity at home affected health. In the relatively egalitarian Swedish environment where women more readily enter all work arenas and men often provide parenting, traditional primacy of the home environment (for women) and the work environment (for men) in shaping health is reversing such that perceived domestic gender inequity has a significant health impact on men, while for women only education and financial strain are contributory. These outcomes were identified only when data were sex-disaggregated.

  17. Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor.

    PubMed

    Lee, Jungsoon; Kim, Ji-Hyun; Biter, Amadeo B; Sielaff, Bernhard; Lee, Sukyeong; Tsai, Francis T F

    2013-05-21

    Heat shock protein (Hsp) 104 is a ring-forming, protein-remodeling machine that harnesses the energy of ATP binding and hydrolysis to drive protein disaggregation. Although Hsp104 is an active ATPase, the recovery of functional protein requires the species-specific cooperation of the Hsp70 system. However, like Hsp104, Hsp70 is an active ATPase, which recognizes aggregated and aggregation-prone proteins, making it difficult to differentiate the mechanistic roles of Hsp104 and Hsp70 during protein disaggregation. Mapping the Hsp70-binding sites in yeast Hsp104 using peptide array technology and photo-cross-linking revealed a striking conservation of the primary Hsp70-binding motifs on the Hsp104 middle-domain across species, despite lack of sequence identity. Remarkably, inserting a Strep-Tactin binding motif at the spatially conserved Hsp70-binding site elicits the Hsp104 protein disaggregating activity that now depends on Strep-Tactin but no longer requires Hsp70/40. Consistent with a Strep-Tactin-dependent activation step, we found that full-length Hsp70 on its own could activate the Hsp104 hexamer by promoting intersubunit coordination, suggesting that Hsp70 is an activator of the Hsp104 motor.

  18. Advertising media and cigarette demand.

    PubMed

    Goel, Rajeev K

    2011-01-01

    Using state-level panel data for the USA spanning three decades, this research estimates the demand for cigarettes. The main contribution lies in studying the effects of cigarette advertising disaggregated across five qualitatively different groups. Results show cigarette demand to be near unit elastic, the income effects to be generally insignificant and border price effects and habit effects to be significant. Regarding advertising effects, aggregate cigarette advertising has a negative effect on smoking. Important differences across advertising media emerge when cigarette advertising is disaggregated. The effects of public entertainment and Internet cigarette advertising are stronger than those of other media. Anti-smoking messages accompanying print cigarette advertising seem relatively more effective. Implications for smoking control policy are discussed.

  19. Computer-based coding of free-text job descriptions to efficiently identify occupations in epidemiological studies.

    PubMed

    Russ, Daniel E; Ho, Kwan-Yuet; Colt, Joanne S; Armenti, Karla R; Baris, Dalsu; Chow, Wong-Ho; Davis, Faith; Johnson, Alison; Purdue, Mark P; Karagas, Margaret R; Schwartz, Kendra; Schwenn, Molly; Silverman, Debra T; Johnson, Calvin A; Friesen, Melissa C

    2016-06-01

    Mapping job titles to standardised occupation classification (SOC) codes is an important step in identifying occupational risk factors in epidemiological studies. Because manual coding is time-consuming and has moderate reliability, we developed an algorithm called SOCcer (Standardized Occupation Coding for Computer-assisted Epidemiologic Research) to assign SOC-2010 codes based on free-text job description components. Job title and task-based classifiers were developed by comparing job descriptions to multiple sources linking job and task descriptions to SOC codes. An industry-based classifier was developed based on the SOC prevalence within an industry. These classifiers were used in a logistic model trained using 14 983 jobs with expert-assigned SOC codes to obtain empirical weights for an algorithm that scored each SOC/job description. We assigned the highest scoring SOC code to each job. SOCcer was validated in 2 occupational data sources by comparing SOC codes obtained from SOCcer to expert assigned SOC codes and lead exposure estimates obtained by linking SOC codes to a job-exposure matrix. For 11 991 case-control study jobs, SOCcer-assigned codes agreed with 44.5% and 76.3% of manually assigned codes at the 6-digit and 2-digit level, respectively. Agreement increased with the score, providing a mechanism to identify assignments needing review. Good agreement was observed between lead estimates based on SOCcer and manual SOC assignments (κ 0.6-0.8). Poorer performance was observed for inspection job descriptions, which included abbreviations and worksite-specific terminology. Although some manual coding will remain necessary, using SOCcer may improve the efficiency of incorporating occupation into large-scale epidemiological studies. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  20. Underreporting, crash severity and fault assignment of minor crashes in China - a study based on self-reported surveys.

    PubMed

    Yang, Hongtai; Cherry, Christopher R; Su, Fan; Ling, Ziwen; Pannell, Zane; Li, Yanlai; Fu, Zhijian

    2018-05-25

    Unreported minor crashes have importance as a surrogate for more serious crashes that require infrastructure, education, and enforcement strategies; and they still inflict damages. To study factors that influence underreporting, cause, and severity of minor crashes; a survey was performed in Kunming and Beijing to collect self-reported personal characteristics and crash history data of the three major urban road users in China: automobile drivers, bicycle riders and electric bike (e-bike) riders. Underreporting rates of automobile to automobile, automobile to non-motorized vehicle, and non-motorized vehicle to non-motorized vehicle crashes are 56%, 77% and 94%, respectively. Minor crashes with higher reported injury severity levels are more likely to be reported. E-bike riders without a driver's license are more likely to cause crashes. Licensing and education could be an effective way to reduce their crashes. The party that is not at fault in a crash is more likely to sustain high level of injury.

  1. Selection of comparison crash types for quasi-induced exposure risk estimation.

    PubMed

    Keall, Michael; Newstead, Stuart

    2009-03-01

    The objective of this study was to find a comparison crash type that best represented exposure on the road and to identify situations where the induced exposure risk estimates were likely to be biased. Counts of crash involvements were compared with distance driven estimates derived from a register of licensed motor vehicles to identify the most appropriate comparison crash type for induced exposure estimation, which is the crash type whose counts are best correlated with vehicle distance driven. The best sets of comparison crashes for disaggregations by driver age and gender and vehicle type were found to be multi-vehicle crashes in which the vehicle was damaged in the rear or multi-vehicle crashes in which the driver was adjudged to be not at fault. Likely bias of induced exposure risk estimates was identified, even for these best sets of comparison crashes, according to vehicle size (with large vehicles underrepresented) and owner age and gender (with young owners and female owners overrepresented). This research identified some important features of crash occurrence useful for making choices of comparison crash types when controlling for exposure. None of the crash types considered as comparison crashes performed perfectly. Even the crash types that seemed to best reflect exposure on the road still appeared to over- or underestimate distance driven according to owner age group, gender, and vehicle size.

  2. A downscaling scheme for atmospheric variables to drive soil-vegetation-atmosphere transfer models

    NASA Astrophysics Data System (ADS)

    Schomburg, A.; Venema, V.; Lindau, R.; Ament, F.; Simmer, C.

    2010-09-01

    For driving soil-vegetation-transfer models or hydrological models, high-resolution atmospheric forcing data is needed. For most applications the resolution of atmospheric model output is too coarse. To avoid biases due to the non-linear processes, a downscaling system should predict the unresolved variability of the atmospheric forcing. For this purpose we derived a disaggregation system consisting of three steps: (1) a bi-quadratic spline-interpolation of the low-resolution data, (2) a so-called `deterministic' part, based on statistical rules between high-resolution surface variables and the desired atmospheric near-surface variables and (3) an autoregressive noise-generation step. The disaggregation system has been developed and tested based on high-resolution model output (400m horizontal grid spacing). A novel automatic search-algorithm has been developed for deriving the deterministic downscaling rules of step 2. When applied to the atmospheric variables of the lowest layer of the atmospheric COSMO-model, the disaggregation is able to adequately reconstruct the reference fields. Applying downscaling step 1 and 2, root mean square errors are decreased. Step 3 finally leads to a close match of the subgrid variability and temporal autocorrelation with the reference fields. The scheme can be applied to the output of atmospheric models, both for stand-alone offline simulations, and a fully coupled model system.

  3. Relative Health Effects of Education, Socioeconomic Status and Domestic Gender Inequity in Sweden: A Cohort Study

    PubMed Central

    Phillips, Susan P.; Hammarström, Anne

    2011-01-01

    Introduction Limited existing research on gender inequities suggests that for men workplace atmosphere shapes wellbeing while women are less susceptible to socioeconomic or work status but vulnerable to home inequities. Methods Using the 2007 Northern Swedish Cohort (n = 773) we identified relative contributions of perceived gender inequities in relationships, financial strain, and education to self-reported health to determine whether controlling for sex, examining interactions between sex and other social variables, or sex-disaggregating data yielded most information about sex differences. Results and Discussion Men had lower education but also less financial strain, and experienced less gender inequity. Overall, low education and financial strain detracted from health. However, sex-disaggregated data showed this to be true for women, whereas for men only gender inequity at home affected health. In the relatively egalitarian Swedish environment where women more readily enter all work arenas and men often provide parenting, traditional primacy of the home environment (for women) and the work environment (for men) in shaping health is reversing such that perceived domestic gender inequity has a significant health impact on men, while for women only education and financial strain are contributory. These outcomes were identified only when data were sex-disaggregated. PMID:21747922

  4. Generating Daily Synthetic Landsat Imagery by Combining Landsat and MODIS Data

    PubMed Central

    Wu, Mingquan; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

    2015-01-01

    Owing to low temporal resolution and cloud interference, there is a shortage of high spatial resolution remote sensing data. To address this problem, this study introduces a modified spatial and temporal data fusion approach (MSTDFA) to generate daily synthetic Landsat imagery. This algorithm was designed to avoid the limitations of the conditional spatial temporal data fusion approach (STDFA) including the constant window for disaggregation and the sensor difference. An adaptive window size selection method is proposed in this study to select the best window size and moving steps for the disaggregation of coarse pixels. The linear regression method is used to remove the influence of differences in sensor systems using disaggregated mean coarse reflectance by testing and validation in two study areas located in Xinjiang Province, China. The results show that the MSTDFA algorithm can generate daily synthetic Landsat imagery with a high correlation coefficient (R) ranged from 0.646 to 0.986 between synthetic images and the actual observations. We further show that MSTDFA can be applied to 250 m 16-day MODIS MOD13Q1 products and the Landsat Normalized Different Vegetation Index (NDVI) data by generating a synthetic NDVI image highly similar to actual Landsat NDVI observation with a high R of 0.97. PMID:26393607

  5. Generating Daily Synthetic Landsat Imagery by Combining Landsat and MODIS Data.

    PubMed

    Wu, Mingquan; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

    2015-09-18

    Owing to low temporal resolution and cloud interference, there is a shortage of high spatial resolution remote sensing data. To address this problem, this study introduces a modified spatial and temporal data fusion approach (MSTDFA) to generate daily synthetic Landsat imagery. This algorithm was designed to avoid the limitations of the conditional spatial temporal data fusion approach (STDFA) including the constant window for disaggregation and the sensor difference. An adaptive window size selection method is proposed in this study to select the best window size and moving steps for the disaggregation of coarse pixels. The linear regression method is used to remove the influence of differences in sensor systems using disaggregated mean coarse reflectance by testing and validation in two study areas located in Xinjiang Province, China. The results show that the MSTDFA algorithm can generate daily synthetic Landsat imagery with a high correlation coefficient (R) ranged from 0.646 to 0.986 between synthetic images and the actual observations. We further show that MSTDFA can be applied to 250 m 16-day MODIS MOD13Q1 products and the Landsat Normalized Different Vegetation Index (NDVI) data by generating a synthetic NDVI image highly similar to actual Landsat NDVI observation with a high R of 0.97.

  6. Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

    PubMed

    Deville, Célia; Carroni, Marta; Franke, Kamila B; Topf, Maya; Bukau, Bernd; Mogk, Axel; Saibil, Helen R

    2017-08-01

    Refolding aggregated proteins is essential in combating cellular proteotoxic stress. Together with Hsp70, Hsp100 chaperones, including Escherichia coli ClpB, form a powerful disaggregation machine that threads aggregated polypeptides through the central pore of tandem adenosine triphosphatase (ATPase) rings. To visualize protein disaggregation, we determined cryo-electron microscopy structures of inactive and substrate-bound ClpB in the presence of adenosine 5'- O -(3-thiotriphosphate), revealing closed AAA+ rings with a pronounced seam. In the substrate-free state, a marked gradient of resolution, likely corresponding to mobility, spans across the AAA+ rings with a dynamic hotspot at the seam. On the seam side, the coiled-coil regulatory domains are locked in a horizontal, inactive orientation. On the opposite side, the regulatory domains are accessible for Hsp70 binding, substrate targeting, and activation. In the presence of the model substrate casein, the polypeptide threads through the entire pore channel and increased nucleotide occupancy correlates with higher ATPase activity. Substrate-induced domain displacements indicate a pathway of regulated substrate transfer from Hsp70 to the ClpB pore, inside which a spiral of loops contacts the substrate. The seam pore loops undergo marked displacements, along with ordering of the regulatory domains. These asymmetric movements suggest a mechanism for ATPase activation and substrate threading during disaggregation.

  7. Reducing equifinality of hydrological models by integrating Functional Streamflow Disaggregation

    NASA Astrophysics Data System (ADS)

    Lüdtke, Stefan; Apel, Heiko; Nied, Manuela; Carl, Peter; Merz, Bruno

    2014-05-01

    A universal problem of the calibration of hydrological models is the equifinality of different parameter sets derived from the calibration of models against total runoff values. This is an intrinsic problem stemming from the quality of the calibration data and the simplified process representation by the model. However, discharge data contains additional information which can be extracted by signal processing methods. An analysis specifically developed for the disaggregation of runoff time series into flow components is the Functional Streamflow Disaggregation (FSD; Carl & Behrendt, 2008). This method is used in the calibration of an implementation of the hydrological model SWIM in a medium sized watershed in Thailand. FSD is applied to disaggregate the discharge time series into three flow components which are interpreted as base flow, inter-flow and surface runoff. In addition to total runoff, the model is calibrated against these three components in a modified GLUE analysis, with the aim to identify structural model deficiencies, assess the internal process representation and to tackle equifinality. We developed a model dependent (MDA) approach calibrating the model runoff components against the FSD components, and a model independent (MIA) approach comparing the FSD of the model results and the FSD of calibration data. The results indicate, that the decomposition provides valuable information for the calibration. Particularly MDA highlights and discards a number of standard GLUE behavioural models underestimating the contribution of soil water to river discharge. Both, MDA and MIA yield to a reduction of the parameter ranges by a factor up to 3 in comparison to standard GLUE. Based on these results, we conclude that the developed calibration approach is able to reduce the equifinality of hydrological model parameterizations. The effect on the uncertainty of the model predictions is strongest by applying MDA and shows only minor reductions for MIA. Besides further validation of FSD, the next steps include an extension of the study to different catchments and other hydrological models with a similar structure.

  8. Development of a spatio-temporal disaggregation method (DisNDVI) for generating a time series of fine resolution NDVI images

    NASA Astrophysics Data System (ADS)

    Bindhu, V. M.; Narasimhan, B.

    2015-03-01

    Normalized Difference Vegetation Index (NDVI), a key parameter in understanding the vegetation dynamics, has high spatial and temporal variability. However, continuous monitoring of NDVI is not feasible at fine spatial resolution (<60 m) owing to the long revisit time needed by the satellites to acquire the fine spatial resolution data. Further, the study attains significance in the case of humid tropical regions of the earth, where the prevailing atmospheric conditions restrict availability of fine resolution cloud free images at a high temporal frequency. As an alternative to the lack of high resolution images, the current study demonstrates a novel disaggregation method (DisNDVI) which integrates the spatial information from a single fine resolution image and temporal information in terms of crop phenology from time series of coarse resolution images to generate estimates of NDVI at fine spatial and temporal resolution. The phenological variation of the pixels captured at the coarser scale provides the basis for relating the temporal variability of the pixel with the NDVI available at fine resolution. The proposed methodology was tested over a 30 km × 25 km spatially heterogeneous study area located in the south of Tamil Nadu, India. The robustness of the algorithm was assessed by an independent comparison of the disaggregated NDVI and observed NDVI obtained from concurrent Landsat ETM+ imagery. The results showed good spatial agreement across the study area dominated with agriculture and forest pixels, with a root mean square error of 0.05. The validation done at the coarser scale showed that disaggregated NDVI spatially averaged to 240 m compared well with concurrent MODIS NDVI at 240 m (R2 > 0.8). The validation results demonstrate the effectiveness of DisNDVI in improving the spatial and temporal resolution of NDVI images for utility in fine scale hydrological applications such as crop growth monitoring and estimation of evapotranspiration.

  9. The ascent of kimberlite: Insights from olivine

    NASA Astrophysics Data System (ADS)

    Brett, R. C.; Russell, J. K.; Andrews, G. D. M.; Jones, T. J.

    2015-08-01

    Olivine xenocrysts are ubiquitous in kimberlite deposits worldwide and derive from the disaggregation of mantle-derived peridotitic xenoliths. Here, we provide descriptions of textural features in xenocrystic olivine from kimberlite deposits at the Diavik Diamond Mine, Canada and at Igwisi Hills volcano, Tanzania. We establish a relative sequence of textural events recorded by olivine during magma ascent through the cratonic mantle lithosphere, including: xenolith disaggregation, decompression fracturing expressed as mineral- and fluid-inclusion-rich sealed and healed cracks, grain size and shape modification by chemical dissolution and abrasion, late-stage crystallization of overgrowths on olivine xenocrysts, and lastly, mechanical milling and rounding of the olivine cargo prior to emplacement. Ascent through the lithosphere operates as a "kimberlite factory" wherein progressive upward dyke propagation of the initial carbonatitic melt fractures the overlying mantle to entrain and disaggregate mantle xenoliths. Preferential assimilation of orthopyroxene (Opx) xenocrysts by the silica-undersaturated carbonatitic melt leads to deep-seated exsolution of CO2-rich fluid generating buoyancy and supporting rapid ascent. Concomitant dissolution of olivine produces irregular-shaped relict grains preserved as cores to most kimberlitic olivine. Multiple generations of decompression cracks in olivine provide evidence for a progression in ambient fluid compositions (e.g., from carbonatitic to silicic) during ascent. Numerical modelling predicts tensile failure of xenoliths (disaggregation) and olivine (cracks) over ascent distances of 2-7 km and 15-25 km, respectively, at velocities of 0.1 to >4 m s-1. Efficient assimilation of Opx during ascent results in a silica-enriched, olivine-saturated kimberlitic melt (i.e. SiO2 >20 wt.%) that crystallizes overgrowths on partially digested and abraded olivine xenocrysts. Olivine saturation is constrained to occur at pressures <1 GPa; an absence of decompression cracks within olivine overgrowths suggests depths <25 km. Late stage (<25 km) resurfacing and reshaping of olivine by particle-particle milling is indicative of turbulent flow conditions within a fully fluidized, gas-charged, crystal-rich magma.

  10. Using software agents to preserve individual health data confidentiality in micro-scale geographical analyses.

    PubMed

    Kamel Boulos, Maged N; Cai, Qiang; Padget, Julian A; Rushton, Gerard

    2006-04-01

    Confidentiality constraints often preclude the release of disaggregate data about individuals, which limits the types and accuracy of the results of geographical health analyses that could be done. Access to individually geocoded (disaggregate) data often involves lengthy and cumbersome procedures through review boards and committees for approval (and sometimes is not possible). Moreover, current data confidentiality-preserving solutions compatible with fine-level spatial analyses either lack flexibility or yield less than optimal results (because of confidentiality-preserving changes they introduce to disaggregate data), or both. In this paper, we present a simulation case study to illustrate how some analyses cannot be (or will suffer if) done on aggregate data. We then quickly review some existing data confidentiality-preserving techniques, and move on to explore a solution based on software agents with the potential of providing flexible, controlled (software-only) access to unmodified confidential disaggregate data and returning only results that do not expose any person-identifiable details. The solution is thus appropriate for micro-scale geographical analyses where no person-identifiable details are required in the final results (i.e., only aggregate results are needed). Our proposed software agent technique also enables post-coordinated analyses to be designed and carried out on the confidential database(s), as needed, compared to a more conventional solution based on the Web Services model that would only support a rigid, pre-coordinated (pre-determined) and rather limited set of analyses. The paper also provides an exploratory discussion of mobility, security, and trust issues associated with software agents, as well as possible directions/solutions to address these issues, including the use of virtual organizations. Successful partnerships between stakeholder organizations, proper collaboration agreements, clear policies, and unambiguous interpretations of laws and regulations are also much needed to support and ensure the success of any technological solution.

  11. DisPATCh as a tool to evaluate coarse-scale remotely sensed soil moisture using localized in situ measurements: Application to SMOS and AMSR-E data in Southeastern Australia

    NASA Astrophysics Data System (ADS)

    Malbéteau, Yoann; Merlin, Olivier; Molero, Beatriz; Rüdiger, Christoph; Bacon, Stephan

    2016-03-01

    Validating coarse-scale satellite soil moisture data still represents a big challenge, notably due to the large mismatch existing between the spatial resolution (> 10 km) of microwave radiometers and the representativeness scale (several m) of localized in situ measurements. This study aims to examine the potential of DisPATCh (Disaggregation based on Physical and Theoretical scale Change) for validating SMOS (Soil Moisture and Ocean Salinity) and AMSR-E (Advanced Microwave Scanning Radiometer-Earth observation system) level-3 soil moisture products. The ∽40-50 km resolution SMOS and AMSR-E data are disaggregated at 1 km resolution over the Murrumbidgee catchment in Southeastern Australia during a one year period in 2010-2011, and the satellite products are compared with the in situ measurements of 38 stations distributed within the study area. It is found that disaggregation improves the mean difference, correlation coefficient and slope of the linear regression between satellite and in situ data in 77%, 92% and 94% of cases, respectively. Nevertheless, the downscaling efficiency is lower in winter than during the hotter months when DisPATCh performance is optimal. Consistently, better results are obtained in the semi-arid than in a temperate zone of the catchment. In the semi-arid Yanco region, disaggregation in summer increases the correlation coefficient from 0.63 to 0.78 and from 0.42 to 0.71 for SMOS and AMSR-E in morning overpasses and from 0.37 to 0.63 and from 0.47 to 0.73 for SMOS and AMSR-E in afternoon overpasses, respectively. DisPATCh has strong potential in low vegetated semi-arid areas where it can be used as a tool to evaluate coarse-scale remotely sensed soil moisture by explicitly representing the sub-pixel variability.

  12. The Challenge of City-Level Data-Gathering for Implementing SDG 11 in Africa

    NASA Astrophysics Data System (ADS)

    Elias, P. O.

    2017-12-01

    Implementing sustainable development goal 11 in Africa which includes measuring and monitoring social and economic welfare indicators at the city-level requires data of the best quality. In recent years, there have been progress in national statistics and censuses survey yet data gathering in many African countries are not accurate, timely, disaggregated and widely usable. This often diminish the capability of governments to tackle urban development challenges, which are particularly exacerbated by inequality, poverty and uncontrolled development especially in cities. To support knowledge driven decisions and policies there is need to improve data-gathering systems about health, education, and safety, economy and poverty, land, housing and environment, trade and commerce, population and demography. Also, the underlying dynamics, processes, distributions, patterns, trends or disparities inherent in African cities require the breaking down of aggregated data into their component parts or smaller units, which underscores urban data revolution towards achieving SDG 11. In Africa, the process of bringing together diverse data communities to embrace a diverse range of data sources, tools, and innovative technologies, to provide disaggregated data for decision-making, service delivery and citizen engagement is still emerging. Several factors are inhibiting urban data revolution and need to be overturned before we can provide more evidence, more data and more certainty for decision makers towards achieving urban development targets and sustainable cities for Africa. The paper examines the challenge of city-level data-gathering for implementing SDG 11 in Africa. Specifically, it examines the role of cities in implementing SDG 11 in Africa and the need to disaggregate data at city-level; it assesses existing data sources, compilation and dissemination channels as well as the challenges of deploying innovative techniques and strategies including digital and social media platforms and concludes with suggesting sustainable options for evolving cutting-edge strategies for integrating diverse data communities for responsible city-level data-gathering that is reliable, timely, disaggregated and widely usable.

  13. Grant Application Development, Submission, Review, & Award

    Cancer.gov

    This infographic shows the National Cancer Institute general timeline progression through Grant Application Development, Submission, Review, and Award Infographic. In the first month, Applicant prepares and submits Grant Application to Grants.gov in response to FOA. In month two, The Center for Scientific Review (CSR) assigns applications that fall under the category of R01s, etc. to a Scientific Review Group (SRG) or the CSR assigns applications that fall under the category of Program Projects and Center Grants to NCI Division of Extramural Activities (DEA). Months four through five: First-level review by Scientific Review Group (SRG) for Scientific Merit: SRG assigns Impact Scores. Month five Summary Sstatements are prepared and are available to NCI Program staff and applicants. Month six, second-level review by National Cancer Advisory board (NCAB) for NCI Funding determination begins. NCAB makes recommendation to NCI Director, NCI develops funding plan, Applications selected for Funding, “Paylists” forwarded to Office of Grant Administration (OGA). Month ten, Award Negotiations and Issuance: Award issued, Award received by Institution, and Investigator begins work. www.cancer.gov Icons made by Freepik from http://www.flaticon.com is licensed by CC BY3.0

  14. Disaggregation and Refinement of System Dynamics Models via Agent-based Modeling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nutaro, James J; Ozmen, Ozgur; Schryver, Jack C

    System dynamics models are usually used to investigate aggregate level behavior, but these models can be decomposed into agents that have more realistic individual behaviors. Here we develop a simple model of the STEM workforce to illuminate the impacts that arise from the disaggregation and refinement of system dynamics models via agent-based modeling. Particularly, alteration of Poisson assumptions, adding heterogeneity to decision-making processes of agents, and discrete-time formulation are investigated and their impacts are illustrated. The goal is to demonstrate both the promise and danger of agent-based modeling in the context of a relatively simple model and to delineate themore » importance of modeling decisions that are often overlooked.« less

  15. A Conceptual Approach to Assimilating Remote Sensing Data to Improve Soil Moisture Profile Estimates in a Surface Flux/Hydrology Model. 3; Disaggregation

    NASA Technical Reports Server (NTRS)

    Caulfield, John; Crosson, William L.; Inguva, Ramarao; Laymon, Charles A.; Schamschula, Marius

    1998-01-01

    This is a followup on the preceding presentation by Crosson and Schamschula. The grid size for remote microwave measurements is much coarser than the hydrological model computational grids. To validate the hydrological models with measurements we propose mechanisms to disaggregate the microwave measurements to allow comparison with outputs from the hydrological models. Weighted interpolation and Bayesian methods are proposed to facilitate the comparison. While remote measurements occur at a large scale, they reflect underlying small-scale features. We can give continuing estimates of the small scale features by correcting the simple 0th-order, starting with each small-scale model with each large-scale measurement using a straightforward method based on Kalman filtering.

  16. Actin cytoskeleton and exocytosis in rat melanotrophs.

    PubMed

    Chowdhury, Helana H; Popoff, Michel R; Zorec, Robert

    2000-01-01

    We monitored secretory activity of single rat melanotrophs by the patch-clamp membrane capacitance measurements (C m ). Secretory activity was stimulated by cytosol dialysis with a patch-pipette solution containing 1μM [Ca 2+ ] i . Actin cytoskeleton was disaggregated by pretreating cells with Clostridium spiroforme toxin, which specifically ADP-ribosylates cellular actin. The extent of cytoskeleton disaggregation was monitored by phalloidin immunostaining. The maximal rate of secretion increases two folds in toxin-treated cells in comparison to controls, whereas the extent of calcium-induced secretory response was similar to that obtained in the non-treated cells. The results show that the subcortical actin network attenuates the rate of secretory activity, which we interpret to reflect a barrier function of cytoskeleton for exocytosis.

  17. Actin cytoskeleton and exocytosis in rat melanotrophs.

    PubMed

    Chowdhury, H H; Popoff, M R; Zorec, R

    2000-01-01

    We monitored secretory activity of single rat melanotrophs by the patch-clamp membrane capacitance measurements (Cm). Secretory activity was stimulated by cytosol dialysis with a patch-pipette solution containing 1 microM [Ca2+]i. Actin cytoskeleton was disaggregated by pretreating cells with Clostridium spiroforme toxin, which specifically ADP-ribosylates cellular actin. The extent of cytoskeleton disaggregation was monitored by phalloidin immunostaining. The maximal rate of secretion increases two folds in toxin-treated cells in comparison to controls, whereas the extent of calcium-induced secretory response was similar to that obtained in the non-treated cells. The results show that the subcortical actin network attenuates the rate of secretory activity, which we interpret to reflect a barrier function of cytoskeleton for exocytosis.

  18. Physician input and licensing of at-risk drivers: a review of all-inclusive medical evaluation forms in the US and Canada.

    PubMed

    Meuser, Thomas M; Berg-Weger, Marla; Niewoehner, Patricia M; Harmon, Annie C; Kuenzie, Jill C; Carr, David B; Barco, Peggy P

    2012-05-01

    This article details a systematic review of medical evaluation forms in support of licensing decisions for medically at-risk drivers. Comparisons were made between all-inclusive forms utilized by 52 State and Provincial Departments of Motor Vehicles (DMVs) in the US and Canada. Comparisons focused on length, format, content, instructional quality, medical coverage, ease of use, and other qualitative characteristics. Median page length was 2 (range 1-10), and mean word count was 1083 (494-3884). Common response options included open-ended (98%), forced choice (87%), and check box (81%). While the majority of forms (77%) required driver consent, only 24% requested information from the driver. Less than half (46%) included text on confidentiality protection. While all forms requested general medical information, just over half included specific sections for vision (54%) and cognitive/neurological conditions (56%). Most forms (81%) required that a judgment be made concerning driver safety, and half prompted for possible license restrictions. Criterion-based quality ratings were assigned on a five-point Likert scale by group consensus. One third of forms were rated as marginal or poor in comprehensiveness and utility, and just two garnered an excellent overall rating. Findings are discussed relative to current research on driver fitness and elements of a proposed model form. Best practice recommendations include a page length limitation, emphasis on in-person evaluation (i.e., as opposed to a records-only review), prompts to collect crash and other driving history information, clear instructions and stepwise format, content prompts across relevant medical categories, documentation of functional status and impairment levels, options for driving with restrictions in lieu of de-licensing, and emphasis on relative (vs. absolute) clinical judgments of overall driver safety. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. 78 FR 59708 - Prospective Grant of Exclusive Commercialization License: The Use of Cysteamine for the Treatment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ...This notice, in accordance with 35 U.S.C. 209 and 37 CFR part 404, indicates that the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive commercialization license to practice the inventions embodied in technology family E-219-2013/0, including U.S. patent application 61/ 814,010 entitled ``A Novel Role of Cysteamine in Suppression of Cancer Invasion and Metastasis and Prolonging Survival of Host Through Inhibition of Matrix Metalloproteinases in Human Cancer'' [HHS Ref. E- 219-2013/0-US-01], Canadian patent application 2,813,514 entitled ``Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases'' [HHS Ref. E-219-2013/0-CA-02], South Korean patent application 10-2013- 43713 entitled ``Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases''[HHS Ref. E-219-2013/0-KR-03], Australian patent application 2013205350 entitled ``Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases'' [HHS Ref. E-219-2013/0-AU-04], and Mexican patent application MX/a/2013/004423 entitled ``Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases'' [HHS Ref. E-219-2013/0-MX-05]; and all related continuing and foreign patents/patent applications for these technology families, to Raptor Pharmaceuticals, Inc. The patent rights in these inventions have been assigned to and/or exclusively licensed to the Government of the United States of America. The prospective exclusive commercialization license territory may be worldwide, and the field of use may be limited to: The treatment of pancreatic cancer, breast cancer and hepatocellular carcinoma (HCC) by using compositions containing cysteamine.

  20. Tests of transferability and validation of disaggregate behavioral demand models for evaluating the energy conservation potential of alternative transportation policies in nine US cities. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1977-04-01

    A transportation policy analysis methodology described in Guidelines for Travel Demand Analyses of Program Measures to Promote Carpools, Vanpools, and Public Transportation, November, 1976 (EAPA 4:1921) is demonstrated. The results reported build upon the two levels of analysis capabilities (a fully calibrated and operational computer package based on a set of disaggregate travel demand models that were estimated on a random sample of urban travelers and a manual procedure or sketch planning pivot-point version of the above methodology) and have undertaken to accomplish the following objectives: transferability, testing the manual approach on actual applications, and validating the method. The firstmore » objective was investigated by examining and comparing disaggregate models that were estimated in 7 US cities by eight different organizations. The next two objectives were investigated using separate case studies: the Washington, DC, Shirley Highway preferential transit and carpool lanes; the Portland, Oregon, Banfield Highway Expressway preferential transit and carpool lanes; the Los Angeles, Santa Monica Freeway preferential Diamond Lane and ramp metering facilities for transit and carpools; the Minneapolis, express bus on metered freeway project; and the Portland, Oregon, carpool matching and promotion programs for the general public and for employer-based groups. Principal findings are summarized and results consolidated. (MCW)« less

  1. Abciximab, eptifibatide, and tirofiban exhibit dose-dependent potencies to dissolve platelet aggregates.

    PubMed

    Moser, Martin; Bertram, Ulf; Peter, Karlheinz; Bode, Christoph; Ruef, Johannes

    2003-04-01

    Platelet GPIIb/IIIa antagonists are not only used to prevent platelet aggregation, but also in combination with thrombolytic agents for the treatment of coronary thrombi. Recent data indicate a potential of abciximab alone to dissolve thrombi in vivo. We investigated the potential of abciximab, eptifibatide, and tirofiban to dissolve platelet aggregates in vitro. Adenosine diphosphate (ADP)-induced platelet aggregation could be reversed in a concentration-dependent manner by all three GPIIb/IIIa antagonists when added after the aggregation curve reached half-maximal aggregation. The concentrations chosen are comparable with in vivo plasma concentrations in clinical applications. Disaggregation reached a maximum degree of 72.4% using 0.5 microg/ml tirofiban, 91.5% using 3.75 microg/ml eptifibatide, and 48.4% using 50 microg/ml abciximab (P < 0.05, respectively). A potential fibrinolytic activity of the GPIIb/IIIa antagonists was ruled out by preincubation with aprotinin or by a plasma clot assay. A stable model Chinese hamster ovary (CHO) cell line expressing the activated form of GPIIb/IIIa was used to confirm the disaggregation capacity of GPIIb/IIIa antagonists found in platelets. Not only abciximab, but also eptifibatide and tirofiban have the potential to disaggregate newly formed platelet clusters in vitro. Because enzyme-dependent fibrinolysis does not appear to be involved, competitive removal of fibrinogen by the receptor antagonists is the most likely mechanism.

  2. A portable microfluidic system for rapid measurement of the erythrocyte sedimentation rate.

    PubMed

    Isiksacan, Ziya; Erel, Ozcan; Elbuken, Caglar

    2016-11-29

    The erythrocyte sedimentation rate (ESR) is a frequently used 30 min or 60 min clinical test for screening of several inflammatory conditions, infections, trauma, and malignant diseases, as well as non-inflammatory conditions including prostate cancer and stroke. Erythrocyte aggregation (EA) is a physiological process where erythrocytes form face-to-face linear structures, called rouleaux, at stasis or low shear rates. In this work, we proposed a method for ESR measurement from EA. We developed a microfluidic opto-electro-mechanical system, using which we experimentally showed a significant correlation (R 2 = 0.86) between ESR and EA. The microfluidic system was shown to measure ESR from EA using fingerprick blood in 2 min. 40 μl of whole blood is filled in a disposable polycarbonate cartridge which is illuminated with a near infrared emitting diode. Erythrocytes were disaggregated under the effect of a mechanical shear force using a solenoid pinch valve. Following complete disaggregation, transmitted light through the cartridge was measured using a photodetector for 1.5 min. The intensity level is at its lowest at complete disaggregation and highest at complete aggregation. We calculated ESR from the transmitted signal profile. We also developed another microfluidic cartridge specifically for monitoring the EA process in real-time during ESR measurement. The presented system is suitable for ultrafast, low-cost, and low-sample volume measurement of ESR at the point-of-care.

  3. Bayesian Non-Stationary Index Gauge Modeling of Gridded Precipitation Extremes

    NASA Astrophysics Data System (ADS)

    Verdin, A.; Bracken, C.; Caldwell, J.; Balaji, R.; Funk, C. C.

    2017-12-01

    We propose a Bayesian non-stationary model to generate watershed scale gridded estimates of extreme precipitation return levels. The Climate Hazards Group Infrared Precipitation with Stations (CHIRPS) dataset is used to obtain gridded seasonal precipitation extremes over the Taylor Park watershed in Colorado for the period 1981-2016. For each year, grid cells within the Taylor Park watershed are aggregated to a representative "index gauge," which is input to the model. Precipitation-frequency curves for the index gauge are estimated for each year, using climate variables with significant teleconnections as proxies. Such proxies enable short-term forecasting of extremes for the upcoming season. Disaggregation ratios of the index gauge to the grid cells within the watershed are computed for each year and preserved to translate the index gauge precipitation-frequency curve to gridded precipitation-frequency maps for select return periods. Gridded precipitation-frequency maps are of the same spatial resolution as CHIRPS (0.05° x 0.05°). We verify that the disaggregation method preserves spatial coherency of extremes in the Taylor Park watershed. Validation of the index gauge extreme precipitation-frequency method consists of ensuring extreme value statistics are preserved on a grid cell basis. To this end, a non-stationary extreme precipitation-frequency analysis is performed on each grid cell individually, and the resulting frequency curves are compared to those produced by the index gauge disaggregation method.

  4. Aboard the mid-deck of the Earth-orbiting Space Shuttle Columbia, astronaut Charles J. Brady,

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-78 ONBOARD VIEW --- Aboard the mid-deck of the Earth-orbiting Space Shuttle Columbia, astronaut Charles J. Brady, mission specialist and a licensed amateur radio operator or ham, talks to students on Earth. Some of the crew members devoted some of their off-duty time to continue a long-standing Shuttle tradition of communicating with students and other hams between their shifts of assigned duty. Brady joined four other NASA astronauts and two international payload specialists for almost 17-days of research in support of the Life and Microgravity Spacelab (LMS-1) mission.

  5. Crime Seasonality: Examining the Temporal Fluctuations of Property Crime in Cities With Varying Climates.

    PubMed

    Linning, Shannon J; Andresen, Martin A; Brantingham, Paul J

    2017-12-01

    This study investigates whether crime patterns fluctuate periodically throughout the year using data containing different property crime types in two Canadian cities with differing climates. Using police report data, a series of ordinary least squares (OLS; Vancouver, British Columbia) and negative binomial (Ottawa, Ontario) regressions were employed to examine the corresponding temporal patterns of property crime in Vancouver (2003-2013) and Ottawa (2006-2008). Moreover, both aggregate and disaggregate models were run to examine whether different weather and temporal variables had a distinctive impact on particular offences. Overall, results suggest that cities that experience greater variations in weather throughout the year have more distinct increases of property offences in the summer months and that different climate variables affect certain crime types, thus advocating for disaggregate analysis in the future.

  6. Solar, planetary, and other inert gases in two sieve fractions of a disaggregated Allende sample - A study by stepwise heating extraction

    NASA Technical Reports Server (NTRS)

    Palma, R. L.; Heymann, D.

    1988-01-01

    Inert gases released by stepwise heating of unaltered, strongly magnetic, and weakly magnetic samples from the 0-64 micron and the 105-250 micron fractions of a disaggregated and sieved sample of the Allende meteorite reveal the occurrence of both solar and planetary neon. The origin of the solar neon is thought to be implantation of solar wind ions. The origin of the planetary neon remains unresolved. Heavy isotope enriched components of krypton and xenon have been detected and there are some indications that a light krypton component may also be present. Other than a larger concentration of Xe-129 in the weakly magnetic samples, the signatures of the magnetic separates are isotopically very similar.

  7. Demand modelling of passenger air travel: An analysis and extension, volume 2

    NASA Technical Reports Server (NTRS)

    Jacobson, I. D.

    1978-01-01

    Previous intercity travel demand models in terms of their ability to predict air travel in a useful way and the need for disaggregation in the approach to demand modelling are evaluated. The viability of incorporating non-conventional factors (i.e. non-econometric, such as time and cost) in travel demand forecasting models are determined. The investigation of existing models is carried out in order to provide insight into their strong points and shortcomings. The model is characterized as a market segmentation model. This is a consequence of the strengths of disaggregation and its natural evolution to a usable aggregate formulation. The need for this approach both pedagogically and mathematically is discussed. In addition this volume contains two appendices which should prove useful to the non-specialist in the area.

  8. High-port low-latency optical switch architecture with optical feed-forward buffering for 256-node disaggregated data centers.

    PubMed

    Terzenidis, Nikos; Moralis-Pegios, Miltiadis; Mourgias-Alexandris, George; Vyrsokinos, Konstantinos; Pleros, Nikos

    2018-04-02

    Departing from traditional server-centric data center architectures towards disaggregated systems that can offer increased resource utilization at reduced cost and energy envelopes, the use of high-port switching with highly stringent latency and bandwidth requirements becomes a necessity. We present an optical switch architecture exploiting a hybrid broadcast-and-select/wavelength routing scheme with small-scale optical feedforward buffering. The architecture is experimentally demonstrated at 10Gb/s, reporting error-free performance with a power penalty of <2.5dB. Moreover, network simulations for a 256-node system, revealed low-latency values of only 605nsec, at throughput values reaching 80% when employing 2-packet-size optical buffers, while multi-rack network performance was also investigated.

  9. To what extent clay mineralogy affects soil aggregation? Consequences for soil organic matter stabilization

    NASA Astrophysics Data System (ADS)

    Fernandez-Ugalde, O.; Barré, P.; Hubert, F.; Virto, I.; Chenu, C.; Ferrage, E.; Caner, L.

    2012-12-01

    Aggregation is a key process for soil functioning as it influences C storage, vulnerability to erosion and water holding capacity. While the influence of soil organic C on aggregation has been documented, much less is known about the role of soil mineralogy. Soils usually contain a mixture of clay minerals with contrasted surface properties, which should result on different abilities of clay minerals to aggregation. We took advantage of the intrinsic mineral heterogeneity of a temperate Luvisol to compare the role of clay minerals (illite, smectite, kaolinite, and mixed-layer illite-smectite) in aggregation. In a first step, grassland and tilled soil samples were fractionated in water in aggregate-size classes according to the hierarchical model of aggregation (Tisdall and Oades, 1982). Clay mineralogy and organic C in the aggregate-size classes were analyzed. The results showed that interstratified minerals containing swelling phases accumulated in aggregated fractions (>2 μm) compared to free clay fractions (<2 μm) in the two land-uses. The accumulation increased from large macro-aggregates (>500 μm) to micro-aggregates (50-250 μm). C concentration and C/N ratio followed the opposite trend. These results constitute a clay mineral-based evidence for the hierarchical model of aggregation, which postulates an increasing importance of the reactivity of clay minerals in the formation of micro-aggregates compared to larger aggregates. In the latter aggregates, formation relies on the physical enmeshment of particles by fungal hyphae, and root and microbial exudates. In a second step, micro-aggregates from the tilled soil samples were submitted to increasingly disaggregating treatments by sonication to evaluate the link between their water stability and clay mineralogy. Micro-aggregates with increasing stability showed an increase of interstratified minerals containing swelling phases and C concentration for low intensities of disaggregation (from 0 to 5 J mL-1). This suggests that swelling phases promote their stability. Swelling phases and organic C decreased for greater intensities of disaggregation. These results and the SEM images taken at different disaggregation intensities indicate that when increasing disaggregation intensity above 5 J mL-1, the recovered material consists on sand particles covered by physical coatings of illite and kaolinite. Our results show that different clay minerals have different contribution to soil aggregation. Swelling phases are especially important for water-stable aggregates formation, whereas illite and kaolinite can either contribute to aggregation or been coated to sand grains in "mineral aggregates", without porosity and organic C protection capability. In conclusion, soils with large proportion of swelling clay minerals have greater potential for carbon storage by occlusion in aggregates and greater resistance to erosion. Tisdall JM, Oades JM (1982) Organic matter and water-stable aggregates in soils. J Soil Sci 62: 141-163.

  10. Combination of radar and daily precipitation data to estimate meaningful sub-daily point precipitation extremes

    NASA Astrophysics Data System (ADS)

    Bárdossy, András; Pegram, Geoffrey

    2017-01-01

    The use of radar measurements for the space time estimation of precipitation has for many decades been a central topic in hydro-meteorology. In this paper we are interested specifically in daily and sub-daily extreme values of precipitation at gauged or ungauged locations which are important for design. The purpose of the paper is to develop a methodology to combine daily precipitation observations and radar measurements to estimate sub-daily extremes at point locations. Radar data corrected using precipitation-reflectivity relationships lead to biased estimations of extremes. Different possibilities of correcting systematic errors using the daily observations are investigated. Observed gauged daily amounts are interpolated to unsampled points and subsequently disaggregated using the sub-daily values obtained by the radar. Different corrections based on the spatial variability and the subdaily entropy of scaled rainfall distributions are used to provide unbiased corrections of short duration extremes. Additionally a statistical procedure not based on a matching day by day correction is tested. In this last procedure as we are only interested in rare extremes, low to medium values of rainfall depth were neglected leaving a small number of L days of ranked daily maxima in each set per year, whose sum typically comprises about 50% of each annual rainfall total. The sum of these L day maxima is first iterpolated using a Kriging procedure. Subsequently this sum is disaggregated to daily values using a nearest neighbour procedure. The daily sums are then disaggregated by using the relative values of the biggest L radar based days. Of course, the timings of radar and gauge maxima can be different, so the method presented here uses radar for disaggregating daily gauge totals down to 15 min intervals in order to extract the maxima of sub-hourly through to daily rainfall. The methodologies were tested in South Africa, where an S-band radar operated relatively continuously at Bethlehem from 1998 to 2003, whose scan at 1.5 km above ground [CAPPI] overlapped a dense (10 km spacing) set of 45 pluviometers recording in the same 6-year period. This valuable set of data was obtained from each of 37 selected radar pixels [1 km square in plan] which contained a pluviometer not masked out by the radar foot-print. The pluviometer data were also aggregated to daily totals, for the same purpose. The extremes obtained using disaggregation methods were compared to the observed extremes in a cross validation procedure. The unusual and novel goal was not to obtain the reproduction of the precipitation matching in space and time, but to obtain frequency distributions of the point extremes, which we found to be stable.

  11. Coupling Poisson rectangular pulse and multiplicative microcanonical random cascade models to generate sub-daily precipitation timeseries

    NASA Astrophysics Data System (ADS)

    Pohle, Ina; Niebisch, Michael; Müller, Hannes; Schümberg, Sabine; Zha, Tingting; Maurer, Thomas; Hinz, Christoph

    2018-07-01

    To simulate the impacts of within-storm rainfall variabilities on fast hydrological processes, long precipitation time series with high temporal resolution are required. Due to limited availability of observed data such time series are typically obtained from stochastic models. However, most existing rainfall models are limited in their ability to conserve rainfall event statistics which are relevant for hydrological processes. Poisson rectangular pulse models are widely applied to generate long time series of alternating precipitation events durations and mean intensities as well as interstorm period durations. Multiplicative microcanonical random cascade (MRC) models are used to disaggregate precipitation time series from coarse to fine temporal resolution. To overcome the inconsistencies between the temporal structure of the Poisson rectangular pulse model and the MRC model, we developed a new coupling approach by introducing two modifications to the MRC model. These modifications comprise (a) a modified cascade model ("constrained cascade") which preserves the event durations generated by the Poisson rectangular model by constraining the first and last interval of a precipitation event to contain precipitation and (b) continuous sigmoid functions of the multiplicative weights to consider the scale-dependency in the disaggregation of precipitation events of different durations. The constrained cascade model was evaluated in its ability to disaggregate observed precipitation events in comparison to existing MRC models. For that, we used a 20-year record of hourly precipitation at six stations across Germany. The constrained cascade model showed a pronounced better agreement with the observed data in terms of both the temporal pattern of the precipitation time series (e.g. the dry and wet spell durations and autocorrelations) and event characteristics (e.g. intra-event intermittency and intensity fluctuation within events). The constrained cascade model also slightly outperformed the other MRC models with respect to the intensity-frequency relationship. To assess the performance of the coupled Poisson rectangular pulse and constrained cascade model, precipitation events were stochastically generated by the Poisson rectangular pulse model and then disaggregated by the constrained cascade model. We found that the coupled model performs satisfactorily in terms of the temporal pattern of the precipitation time series, event characteristics and the intensity-frequency relationship.

  12. Getting Under the Hood: How and for Whom Does Increasing Course Structure Work?

    PubMed Central

    Eddy, Sarah L.

    2014-01-01

    At the college level, the effectiveness of active-learning interventions is typically measured at the broadest scales: the achievement or retention of all students in a course. Coarse-grained measures like these cannot inform instructors about an intervention's relative effectiveness for the different student populations in their classrooms or about the proximate factors responsible for the observed changes in student achievement. In this study, we disaggregate student data by racial/ethnic groups and first-generation status to identify whether a particular intervention—increased course structure—works better for particular populations of students. We also explore possible factors that may mediate the observed changes in student achievement. We found that a “moderate-structure” intervention increased course performance for all student populations, but worked disproportionately well for black students—halving the black–white achievement gap—and first-generation students—closing the achievement gap with continuing-generation students. We also found that students consistently reported completing the assigned readings more frequently, spending more time studying for class, and feeling an increased sense of community in the moderate-structure course. These changes imply that increased course structure improves student achievement at least partially through increasing student use of distributed learning and creating a more interdependent classroom community. PMID:25185229

  13. Gender fairness within the Force Concept Inventory

    NASA Astrophysics Data System (ADS)

    Traxler, Adrienne; Henderson, Rachel; Stewart, John; Stewart, Gay; Papak, Alexis; Lindell, Rebecca

    2018-01-01

    Research on the test structure of the Force Concept Inventory (FCI) has largely ignored gender, and research on FCI gender effects (often reported as "gender gaps") has seldom interrogated the structure of the test. These rarely crossed streams of research leave open the possibility that the FCI may not be structurally valid across genders, particularly since many reported results come from calculus-based courses where 75% or more of the students are men. We examine the FCI considering both psychometrics and gender disaggregation (while acknowledging this as a binary simplification), and find several problematic questions whose removal decreases the apparent gender gap. We analyze three samples (total Npre=5391 , Npost=5769 ) looking for gender asymmetries using classical test theory, item response theory, and differential item functioning. The combination of these methods highlights six items that appear substantially unfair to women and two items biased in favor of women. No single physical concept or prior experience unifies these questions, but they are broadly consistent with problematic items identified in previous research. Removing all significantly gender-unfair items halves the gender gap in the main sample in this study. We recommend that instructors using the FCI report the reduced-instrument score as well as the 30-item score, and that credit or other benefits to students not be assigned using the biased items.

  14. Express bus-fringe parking planning methodology.

    DOT National Transportation Integrated Search

    1975-01-01

    The conception, calibration, and evaluation of alternative disaggregate behavioral models of the express bus-fringe parking travel choice situation are described. Survey data collected for the Parham Express Service in Richmond, Virginia, are used to...

  15. 47 CFR 101.1415 - Partitioning and disaggregation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... American Datum (NAD83). (d) Unjust enrichment. 12 GHz licensees that received a bidding credit and... be subject to the provisions concerning unjust enrichment as set forth in § 1.2111 of this chapter...

  16. Subjective time pressure: general or domain specific?

    PubMed

    Kleiner, Sibyl

    2014-09-01

    Chronic time pressure has been identified as a pervasive societal problem, exacerbated by high demands of the labor market and the home. Yet time pressure has not been disaggregated and examined separately across home and work contexts, leaving many unanswered questions regarding the sources and potentially stressful consequences of time pressure. Using data collected in the United States General Social Survey waves 2002 and 2004, this study disaggregates time pressure into the domains of home and work, and asks whether considering time pressures within distinct work and home contexts reveals distinct predictors or associations with stress. Findings show that both predictors and stress associations differ across work and home pressures, revealing both methodological and theoretical implications for the study of time pressure and work and family life more generally. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Continuation Power Flow Analysis for PV Integration Studies at Distribution Feeders

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Jiyu; Zhu, Xiangqi; Lubkeman, David L.

    2017-10-30

    This paper presents a method for conducting continuation power flow simulation on high-solar penetration distribution feeders. A load disaggregation method is developed to disaggregate the daily feeder load profiles collected in substations down to each load node, where the electricity consumption of residential houses and commercial buildings are modeled using actual data collected from single family houses and commercial buildings. This allows the modeling of power flow and voltage profile along a distribution feeder on a continuing fashion for a 24- hour period at minute-by-minute resolution. By separating the feeder into load zones based on the distance between the loadmore » node and the feeder head, we studied the impact of PV penetration on distribution grid operation in different seasons and under different weather conditions for different PV placements.« less

  18. Preparation of Amyloid Fibrils Seeded from Brain and Meninges.

    PubMed

    Scherpelz, Kathryn P; Lu, Jun-Xia; Tycko, Robert; Meredith, Stephen C

    2016-01-01

    Seeding of amyloid fibrils into fresh solutions of the same peptide or protein in disaggregated form leads to the formation of replicate fibrils, with close structural similarity or identity to the original fibrillar seeds. Here we describe procedures for isolating fibrils composed mainly of β-amyloid (Aβ) from human brain and from leptomeninges, a source of cerebral blood vessels, for investigating Alzheimer's disease and cerebral amyloid angiopathy. We also describe methods for seeding isotopically labeled, disaggregated Aβ peptide solutions for study using solid-state NMR and other techniques. These methods should be applicable to other types of amyloid fibrils, to Aβ fibrils from mice or other species, tissues other than brain, and to some non-fibrillar aggregates. These procedures allow for the examination of authentic amyloid fibrils and other protein aggregates from biological tissues without the need for labeling the tissue.

  19. Oxidized quercetin inhibits α-synuclein fibrillization.

    PubMed

    Zhu, Min; Han, Shubo; Fink, Anthony L

    2013-04-01

    α-Synucein is a small (14 kDa), abundant, intrinsically disordered presynaptic protein, whose aggregation is believed to be a critical step in Parkinson's disease (PD). Oxidative stress is reported to be a risk factor for dopamine cell degeneration in PD. Flavonoids are suggested to be important antioxidant against oxidative stress. Flavonoids were reported to inhibit fibrillization and disaggregate the preformed fibrils of α-synucein, but the molecular mechanism was still not clear. Quercetin, a well-recognized flavonoid antioxidant, was tested for its inhibition of α-synucein aggregation by thioflavin T assay, light scattering measurement, size-exclusion high performance liquid chromatography, atomic force microscopy, etc. The pre-incubated quercetin exhibited a noticeably stronger inhibition behavior to the fibril formation than that of the freshly prepared. The inhibition is significant in the presence of ortho- and para-benzenediol isomers and inconsiderable in the presence of meta-isomer. The oxidized quercetin species (i.e., chalcantrione, benzyfuranone, quercetinchinone, and other derivatives) cause stronger inhibition than quercetin does because of the elevated polarity and hydrophilicity. Presence of quercetin disaggregates α-synucein fibrils, rather than oligomers and amorphous aggregations. Instead of the antioxidant activity, the 1:1 covalent binding of quercetin with α-synucein, and the increased hydophilicity of the covalently modified α-synucein oligomers or monomers, account for the inhibition of α-synucein fibrillation. Clarification of the molecular mechanism of the inhibition and disaggregation may help to screen safer and more effective flavonoid therapeutic in combating PD. Copyright © 2012. Published by Elsevier B.V.

  20. Analysis of uncertainties in the estimates of nitrous oxide and methane emissions in the UK's greenhouse gas inventory for agriculture

    NASA Astrophysics Data System (ADS)

    Milne, Alice E.; Glendining, Margaret J.; Bellamy, Pat; Misselbrook, Tom; Gilhespy, Sarah; Rivas Casado, Monica; Hulin, Adele; van Oijen, Marcel; Whitmore, Andrew P.

    2014-01-01

    The UK's greenhouse gas inventory for agriculture uses a model based on the IPCC Tier 1 and Tier 2 methods to estimate the emissions of methane and nitrous oxide from agriculture. The inventory calculations are disaggregated at country level (England, Wales, Scotland and Northern Ireland). Before now, no detailed assessment of the uncertainties in the estimates of emissions had been done. We used Monte Carlo simulation to do such an analysis. We collated information on the uncertainties of each of the model inputs. The uncertainties propagate through the model and result in uncertainties in the estimated emissions. Using a sensitivity analysis, we found that in England and Scotland the uncertainty in the emission factor for emissions from N inputs (EF1) affected uncertainty the most, but that in Wales and Northern Ireland, the emission factor for N leaching and runoff (EF5) had greater influence. We showed that if the uncertainty in any one of these emission factors is reduced by 50%, the uncertainty in emissions of nitrous oxide reduces by 10%. The uncertainty in the estimate for the emissions of methane emission factors for enteric fermentation in cows and sheep most affected the uncertainty in methane emissions. When inventories are disaggregated (as that for the UK is) correlation between separate instances of each emission factor will affect the uncertainty in emissions. As more countries move towards inventory models with disaggregation, it is important that the IPCC give firm guidance on this topic.

  1. Nursing's new frontier: reinventing our practice in a restructured health care system.

    PubMed

    Barter, M; Furmidge, M L

    1995-12-01

    Nurse managers who are faced with the challenge of maintaining productivity in today's turbulent health care environment need new strategies for managing a redesigned workforce. Registered nurses have assumed leadership responsibilities in work teams that include other nurses, licensed personnel from other disciplines, and unlicensed assistive personnel (UAP). Myths, rumors, and questions deserve thoughtful consideration and response if managers want full cooperation from team leaders. Legal and professional issues relating to assignment, delegation, and supervision of a multidisciplinary team must be understood by everyone. Team leaders must have clearly defined boundaries of authority and an understanding of the competencies of each team member to be effective.

  2. Description of Data Acquisition Efforts

    DOT National Transportation Integrated Search

    1999-09-01

    As part of the overall strategy of refining and improving the existing transportation and air-quality modeling framework, the current project focuses extensively on acquiring disaggregate and reliable data for analysis. In this report, we discuss the...

  3. A tale of two cities: the effect of extended drinking hours in licensed establishments on impaired driving and assault charges.

    PubMed

    Vingilis, Evelyn; Mcleod, A Ian; Mann, Robert E; Seeley, Jane

    2008-12-01

    On May 1, 1996, Ontario, Canada, amended the Liquor Licence Act to extend the hours of alcohol sales and service in licensed establishments from 1 to 2 a.m. The purpose of this study was to examine the effect of extended drinking hours on two cities in southwestern Ontario, Canada, one of which (London) would be affected by the alcohol control policy of extended drinking hours and the second city (Windsor) would be affected by two alcohol policies, extended drinking hours, and cross-border legal drinking age differences between Ontario and Michigan. Specifically, this study tested whether there were differences in impaired driving and assault charges in London and Windsor, Ontario, concomitant with the extended drinking hour amendment. A quasi-experimental design using interrupted time series was used to assess changes. The analyzed data sets were monthly police impaired driving and assault charges data for Ontario, for the 11-12 p.m., 12-1 a.m., 1-2 a.m., 2-3 a.m. and 3-4 a.m. time windows, for 4 years pre- and 3 years post-policy change. Overall, London and Windsor exhibited significant overall reductions in impaired driving charges and no changes for assault charges aggregated over the 11 p.m.-4 a.m. time period after the drinking hours were extended. Within the different time windows, London showed significant decreases for the 1-2 a.m. Sunday-Wednesday and Thursday-Sunday time periods and a significant increase for the Sunday-Wednesday 3-4 a.m. time period, while Windsor demonstrated significant decreases in impaired driving charges for 1-2 a.m. Sunday-Wednesday and Thursday-Saturday time periods and significant increases for Sunday-Wednesday 2-3 and 3-4 a.m. and for Thursday-Saturday 2-3 a.m. For assault charges, no overall pre-post differences were found for the aggregated 11 p.m.-4 a.m. time period for either city. When the data were disaggregated by hour, a significant decrease was found in London for Thursday-Saturday 1-2 a.m. and significant increases for Sunday-Wednesday 2-3 a.m. and Thursday-Saturday 3-4 a.m. time periods, while no significant decreases were found in Windsor during the 1-2 a.m. time periods and one significant increase occurred during the Thursday-Saturday 2-3 a.m. time period. These findings, based on police data, suggest no overall effect on charges aggregated over the 11 p.m. to 4 a.m. time window, although some differences were observed for the different hours after 2 a.m., with a possible effect of the one hour extension of drinking in licensed establishments.

  4. Combination of radar and daily precipitation data to estimate meaningful sub-daily point precipitation extremes

    NASA Astrophysics Data System (ADS)

    Pegram, Geoff; Bardossy, Andras; Sinclair, Scott

    2017-04-01

    The use of radar measurements for the space time estimation of precipitation has for many decades been a central topic in hydro-meteorology. In this presentation we are interested specifically in daily and sub-daily extreme values of precipitation at gauged or ungauged locations which are important for design. The purpose of the presentation is to develop a methodology to combine daily precipitation observations and radar measurements to estimate sub-daily extremes at point locations. Radar data corrected using precipitation-reflectivity relationships lead to biased estimations of extremes. Different possibilities of correcting systematic errors using the daily observations are investigated. Observed gauged daily amounts are interpolated to un-sampled points and subsequently disaggregated using the sub-daily values obtained by the radar. Different corrections based on the spatial variability and the sub-daily entropy of scaled rainfall distributions are used to provide unbiased corrections of short duration extremes. In addition, a statistical procedure not based on a matching day by day correction is tested. In this last procedure, as we are only interested in rare extremes, low to medium values of rainfall depth were neglected leaving 12 days of ranked daily maxima in each set per year, whose sum typically comprises about 50% of each annual rainfall total. The sum of these 12 day maxima is first interpolated using a Kriging procedure. Subsequently this sum is disaggregated to daily values using a nearest neighbour procedure. The daily sums are then disaggregated by using the relative values of the biggest 12 radar based days in each year. Of course, the timings of radar and gauge maxima can be different, so the new method presented here uses radar for disaggregating daily gauge totals down to 15 min intervals in order to extract the maxima of sub-hourly through to daily rainfall. The methodologies were tested in South Africa, where an S-band radar operated relatively continuously at Bethlehem from 1998 to 2003, whose scan at 1.5 km above ground [CAPPI] overlapped a dense [10 km spacing] set of 45 pluviometers recording in the same 6-year period. This valuable set of data was obtained from each of 37 selected radar pixels [1 km square in plan] which contained a pluviometer, not masked out by the radar foot-print. The pluviometer data were also aggregated to daily totals, for the same purpose. The extremes obtained using disaggregation methods were compared to the observed extremes in a cross validation procedure. The unusual and novel goal was not to obtain the reproduction of the precipitation matching in space and time, but to obtain frequency distributions of the point extremes, which we found to be stable. Published as: Bárdossy, A., and G. G. S. Pegram (2017) Journal of Hydrology, Volume 544, pp 397-406

  5. 75 FR 74863 - Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-01

    ... regarding that topic, rather than here. For example, ``aggregation'' is addressed in Sec. 158.120... would disaggregate products by type of coverage--for example, HMO, PPO, and high-deductible coverage...

  6. Phoenix model

    EPA Science Inventory

    Phoenix (formerly referred to as the Second Generation Model or SGM) is a global general equilibrium model designed to analyze energy-economy-climate related questions and policy implications in the medium- to long-term. This model disaggregates the global economy into 26 industr...

  7. A procedural method for express bus-fringe parking transit planning.

    DOT National Transportation Integrated Search

    1976-01-01

    The report illustrates a procedural method for planning express bus-fringe parking transit services - a method built upon the findings from previous research, including disaggregate travel choice models and planning guidelines. The methodology addres...

  8. Integrating Safety in Developing a Variable Speed Limit System

    DOT National Transportation Integrated Search

    2014-01-01

    Disaggregate safety studies benefit from the reliable surveillance systems which provide detailed real-time traffic and weather data. This information could help in capturing microlevel influences of the hazardous factors which might lead to a crash....

  9. Voltage-Load Sensitivity Matrix Based Demand Response for Voltage Control in High Solar Penetration Distribution Feeders

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhu, Xiangqi; Wang, Jiyu; Mulcahy, David

    This paper presents a voltage-load sensitivity matrix (VLSM) based voltage control method to deploy demand response resources for controlling voltage in high solar penetration distribution feeders. The IEEE 123-bus system in OpenDSS is used for testing the performance of the preliminary VLSM-based voltage control approach. A load disaggregation process is applied to disaggregate the total load profile at the feeder head to each load nodes along the feeder so that loads are modeled at residential house level. Measured solar generation profiles are used in the simulation to model the impact of solar power on distribution feeder voltage profiles. Different casemore » studies involving various PV penetration levels and installation locations have been performed. Simulation results show that the VLSM algorithm performance meets the voltage control requirements and is an effective voltage control strategy.« less

  10. A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier

    PubMed Central

    Le, Tuan-Anh; Amin, Faiz Ul; Kim, Myeong Ok

    2017-01-01

    The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed actuation schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel scheme with an aggregation model for a feed-forward magnetic actuation design. A simulation platform for aggregated particle delivery is developed and an actuation scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic actuation. The experimental results with a Y-shaped channel indicated the success of the proposed scheme in steering and disaggregation. The delivery performance of the developed scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed scheme enhanced the transport and uptake of MNPs across the BBB in mice. The scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic actuation scheme. PMID:29271927

  11. Bilateral Trade Flows and Income Distribution Similarity.

    PubMed

    Martínez-Zarzoso, Inmaculada; Vollmer, Sebastian

    2016-01-01

    Current models of bilateral trade neglect the effects of income distribution. This paper addresses the issue by accounting for non-homothetic consumer preferences and hence investigating the role of income distribution in the context of the gravity model of trade. A theoretically justified gravity model is estimated for disaggregated trade data (Dollar volume is used as dependent variable) using a sample of 104 exporters and 108 importers for 1980-2003 to achieve two main goals. We define and calculate new measures of income distribution similarity and empirically confirm that greater similarity of income distribution between countries implies more trade. Using distribution-based measures as a proxy for demand similarities in gravity models, we find consistent and robust support for the hypothesis that countries with more similar income-distributions trade more with each other. The hypothesis is also confirmed at disaggregated level for differentiated product categories.

  12. Integration of Multiple Data Sources to Simulate the Dynamics of Land Systems

    PubMed Central

    Deng, Xiangzheng; Su, Hongbo; Zhan, Jinyan

    2008-01-01

    In this paper we present and develop a new model, which we have called Dynamics of Land Systems (DLS). The DLS model is capable of integrating multiple data sources to simulate the dynamics of a land system. Three main modules are incorporated in DLS: a spatial regression module, to explore the relationship between land uses and influencing factors, a scenario analysis module of the land uses of a region during the simulation period and a spatial disaggregation module, to allocate land use changes from a regional level to disaggregated grid cells. A case study on Taips County in North China is incorporated in this paper to test the functionality of DLS. The simulation results under the baseline, economic priority and environmental scenarios help to understand the land system dynamics and project near future land-use trajectories of a region, in order to focus management decisions on land uses and land use planning. PMID:27879726

  13. PERSISTENCE OF MESSENGER RNA THROUGH MITOSIS IN HELA CELLS

    PubMed Central

    Hodge, L. D.; Robbins, E.; Scharff, M. D.

    1969-01-01

    The decrease in protein synthesis which occurs in mammalian cells during cell division is associated with significant disaggregation of polyribosomes. For determining whether messenger RNA survives this disaggregation, the reformation of polyribosomes was investigated in synchronized HeLa cells as they progressed from metaphase into interphase in the presence of 2 µg/ml Actinomycin D. The persistence of messenger during cell division was evidenced by: (1) a progressive increase in the rate of protein synthesis in both treated and untreated cells for 45 min after metaphase; (2) reformation of polyribosomes, as determined by both sucrose gradients and electron microscopy, within 30 min after the addition of Actinomycin D to metaphase cells; (3) the persistence of approximately 50% of the rapidly labeled nonribosomal RNA which had associated with polyribosomes just before metaphase; (4) the resumption of synthesis, following cell division, of 6 selected peptides in Actinomycin-treated cells. PMID:5761922

  14. Bilateral Trade Flows and Income Distribution Similarity

    PubMed Central

    2016-01-01

    Current models of bilateral trade neglect the effects of income distribution. This paper addresses the issue by accounting for non-homothetic consumer preferences and hence investigating the role of income distribution in the context of the gravity model of trade. A theoretically justified gravity model is estimated for disaggregated trade data (Dollar volume is used as dependent variable) using a sample of 104 exporters and 108 importers for 1980–2003 to achieve two main goals. We define and calculate new measures of income distribution similarity and empirically confirm that greater similarity of income distribution between countries implies more trade. Using distribution-based measures as a proxy for demand similarities in gravity models, we find consistent and robust support for the hypothesis that countries with more similar income-distributions trade more with each other. The hypothesis is also confirmed at disaggregated level for differentiated product categories. PMID:27137462

  15. A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood-Brain Barrier.

    PubMed

    Hoshiar, Ali Kafash; Le, Tuan-Anh; Amin, Faiz Ul; Kim, Myeong Ok; Yoon, Jungwon

    2017-12-22

    The blood-brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed actuation schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel scheme with an aggregation model for a feed-forward magnetic actuation design. A simulation platform for aggregated particle delivery is developed and an actuation scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic actuation. The experimental results with a Y-shaped channel indicated the success of the proposed scheme in steering and disaggregation. The delivery performance of the developed scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed scheme enhanced the transport and uptake of MNPs across the BBB in mice. The scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic actuation scheme.

  16. Methodological Issues in the Collection, Analysis, and Reporting of Granular Data in Asian American Populations: Historical Challenges and Potential Solutions

    PubMed Central

    Islam, Nadia Shilpi; Khan, Suhaila; Kwon, Simona; Jang, Deeana; Ro, Marguerite; Trinh-Shevrin, Chau

    2011-01-01

    There are close to 15 million Asian Americans living in the United States, and they represent the fastest growing populations in the country. By the year 2050, there will be an estimated 33.4 million Asian Americans living in the country. However, their health needs remain poorly understood and there is a critical lack of data disaggregated by Asian American ethnic subgroups, primary language, and geography. This paper examines methodological issues, challenges, and potential solutions to addressing the collection, analysis, and reporting of disaggregated (or, granular) data on Asian Americans. The article explores emerging efforts to increase granular data through the use of innovative study design and analysis techniques. Concerted efforts to implement these techniques will be critical to the future development of sound research, health programs, and policy efforts targeting this and other minority populations. PMID:21099084

  17. The overall program effects of California's 3-Tier Assessment System pilot on crashes and mobility among senior drivers.

    PubMed

    Camp, Bayliss J

    2013-12-01

    In 2007, the California Department of Motor Vehicles (DMV) undertook a pilot study of the 3-Tier Assessment System, the purpose of which was to examine, in a large-scale real-time public agency setting, the effectiveness of this method for both reducing the crash risk of individual drivers and for extending the safe driving years of Californian drivers of all ages. The 3-Tier Assessment System consisted of tiered series of screening tools incorporated into the in-office driver's license renewal process. These screening tools identified drivers with various kinds of functional limitations (physical, visual, and cognitive/perceptual), that might impact safe driving. Paired with the screening tools were educational materials designed to improve drivers' knowledge of their own limitations, including compensating techniques. The present study is a population-based evaluation of the effects of the pilot on subsequent crash risk and mobility outcomes (including delicensure) of participating drivers age 70 and older. Pilot participants were compared with two control groups processed according to standard California DMV license renewal procedures. Because the 3-Tier Assessment System was designed to identify limitations normally associated with aging, the present analyses focus on drivers age 70 and older. However, it should be emphasized that during the 3-Tier pilot the screening tools were applied to drivers of all ages. There were two main findings. First, there were no consistent, statistically significant differences between the pilot and control groups in crash risk in the two years following screening. Second, pilot participants experienced statistically significant effects on mobility. These effects included delays in time to complete their license renewal, an increase in the number of assigned license restrictions, and an increase in the number of customers failing to renew their driving privilege. Based on these findings, suggestions for further research are made. None. © 2013.

  18. An improved rainfall disaggregation technique for GCMs

    NASA Astrophysics Data System (ADS)

    Onof, C.; Mackay, N. G.; Oh, L.; Wheater, H. S.

    1998-08-01

    Meteorological models represent rainfall as a mean value for a grid square so that when the latter is large, a disaggregation scheme is required to represent the spatial variability of rainfall. In general circulation models (GCMs) this is based on an assumption of exponentiality of rainfall intensities and a fixed value of areal rainfall coverage, dependent on rainfall type. This paper examines these two assumptions on the basis of U.K. and U.S. radar data. Firstly, the coverage of an area is strongly dependent on its size, and this dependence exhibits a scaling law over a range of sizes. Secondly, the coverage is, of course, dependent on the resolution at which it is measured, although this dependence is weak at high resolutions. Thirdly, the time series of rainfall coverages has a long-tailed autocorrelation function which is comparable to that of the mean areal rainfalls. It is therefore possible to reproduce much of the temporal dependence of coverages by using a regression of the log of the mean rainfall on the log of the coverage. The exponential assumption is satisfactory in many cases but not able to reproduce some of the long-tailed dependence of some intensity distributions. Gamma and lognormal distributions provide a better fit in these cases, but they have their shortcomings and require a second parameter. An improved disaggregation scheme for GCMs is proposed which incorporates the previous findings to allow the coverage to be obtained for any area and any mean rainfall intensity. The parameters required are given and some of their seasonal behavior is analyzed.

  19. Using Maximum Likelihood Statistical Methods and Pigment Flux Data to Constrain Particle Exchange and Organic Matter Remineralization Rate Constants in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Wang, W.; Lee, C.; Cochran, K. K.; Armstrong, R. A.

    2016-02-01

    Sinking particles play a pivotal role transferring material from the surface to the deeper ocean via the "biological pump". To quantify the extent to which these particles aggregate and disaggregate, and thus affect particle settling velocity, we constructed a box model to describe organic matter cycling. The box model was fit to chloropigment data sampled in the 2005 MedFlux project using Indented Rotating Sphere sediment traps operating in Settling Velocity (SV) mode. Because of the very different pigment compositions of phytoplankton and fecal pellets, chloropigments are useful as proxies to record particle exchange. The maximum likelihood statistical method was used to estimate particle aggregation, disaggregation, and organic matter remineralization rate constants. Eleven settling velocity categories collected by SV sediment traps were grouped into two sinking velocity classes (fast- and slow-sinking) to decrease the number of parameters that needed to be estimated. Organic matter degradation rate constants were estimated to be 1.2, 1.6, and 1.1 y^-1, which are equivalent to degradation half-lives of 0.60, 0.45, and 0.62 y^-1, at 313, 524, and 1918 m, respectively. Rate constants of chlorophyll a degradation to pheopigments (pheophorbide, pheophytin, and pyropheophorbide) were estimated to be 0.88, 0.93, and 1.2 y^-1, at 313, 524, and 1918 m, respectively. Aggregation rate constants varied little with depth, with the highest value being 0.07 y^-1 at 524 m. Disaggregation rate constants were highest at 524 m (14 y^-1) and lowest at 1918 m (9.6 y^-1)

  20. Investigating heterogeneity in violent offending liability among injection drug users from a developmental perspective.

    PubMed

    Torok, Michelle; Darke, Shane; Shand, Fiona; Kaye, Sharlene

    2016-09-01

    Violence is a major burden of harm among injecting drug users (IDU), however, the liability to violent offending is not well understood. The current study aimed to better understand differences in the liability to violence by determining whether IDU could be disaggregated into distinct violent offending classes, and determining the correlates of class membership. A total of 300 IDU from Sydney, Australia were administered a structured interview examining the prevalence and severity of drug use and violent offending histories, as well as early life risk factors (maltreatment, childhood mental disorder, trait personality). IDU were disaggregated into four distinct latent classes, comprising a non-violent class (24%), an adolescent-onset persistent class (33%), an adult-onset transient class (24%) and an early-onset, chronic class (19%). Pairwise and group comparisons of classes on predispositional and substance use risks showed that the EARLY class had the poorest psychosocial risk profile, while the NON class had the most favourable. Multinomial logistic regression revealed that higher trait impulsivity and aggression scores, having a history of conduct disorder, frequent childhood abuse, and more problematic alcohol use, were independently associated with more temporally stable and severe violent offending. The model explained 67% of variance in class membership (χ(2)=207.7, df=51, p<0.001). IDU can be meaningfully disaggregated into distinct violent offending classes using developmental criteria. The age of onset of violence was indicative of class membership insomuch as that the extent of early life risk exposure was differentially associated with greater long-term liability to violence and drug use. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. A theoretically consistent stochastic cascade for temporal disaggregation of intermittent rainfall

    NASA Astrophysics Data System (ADS)

    Lombardo, F.; Volpi, E.; Koutsoyiannis, D.; Serinaldi, F.

    2017-06-01

    Generating fine-scale time series of intermittent rainfall that are fully consistent with any given coarse-scale totals is a key and open issue in many hydrological problems. We propose a stationary disaggregation method that simulates rainfall time series with given dependence structure, wet/dry probability, and marginal distribution at a target finer (lower-level) time scale, preserving full consistency with variables at a parent coarser (higher-level) time scale. We account for the intermittent character of rainfall at fine time scales by merging a discrete stochastic representation of intermittency and a continuous one of rainfall depths. This approach yields a unique and parsimonious mathematical framework providing general analytical formulations of mean, variance, and autocorrelation function (ACF) for a mixed-type stochastic process in terms of mean, variance, and ACFs of both continuous and discrete components, respectively. To achieve the full consistency between variables at finer and coarser time scales in terms of marginal distribution and coarse-scale totals, the generated lower-level series are adjusted according to a procedure that does not affect the stochastic structure implied by the original model. To assess model performance, we study rainfall process as intermittent with both independent and dependent occurrences, where dependence is quantified by the probability that two consecutive time intervals are dry. In either case, we provide analytical formulations of main statistics of our mixed-type disaggregation model and show their clear accordance with Monte Carlo simulations. An application to rainfall time series from real world is shown as a proof of concept.

  2. Success in Undergraduate Engineering Programs: A Comparative Analysis by Race and Gender

    NASA Astrophysics Data System (ADS)

    Lord, Susan

    2010-03-01

    Interest in increasing the number of engineering graduates in the United States and promoting gender equality and diversification of the profession has encouraged considerable research on women and minorities in engineering programs. Drawing on a framework of intersectionality theory, this work recognizes that women of different ethnic backgrounds warrant disaggregated analysis because they do not necessarily share a common experience in engineering education. Using a longitudinal, comprehensive data set of more than 79,000 students who matriculated in engineering at nine universities in the Southeastern United States, this research examines how the six-year graduation rates of engineering students vary by disaggregated combinations of gender and race/ethnicity. Contrary to the popular opinion that women drop out of engineering at higher rates, our results show that Asian, Black, Hispanic, Native American, and White women who matriculate in engineering are as likely as men to graduate in engineering in six years. In fact, Asian, Black, Hispanic, and Native American women engineering matriculants graduate at higher rates than men and there is a small difference for white students. 54 percent of White women engineering matriculants graduate in six-years compared with 53 percent of white men. For male and female engineering matriculants of all races, the most likely destination six years after entering college is graduation within engineering. This work underscores the importance of research disaggregated by race and gender and points to the critical need for more recruitment of women into engineering as the low representation of women in engineering education is primarily a reflection of their low representation at matriculation.

  3. Analysis of the cooperative ATPase cycle of the AAA+ chaperone ClpB from Thermus thermophilus by using ordered heterohexamers with an alternating subunit arrangement.

    PubMed

    Yamasaki, Takashi; Oohata, Yukiko; Nakamura, Toshiki; Watanabe, Yo-hei

    2015-04-10

    The ClpB/Hsp104 chaperone solubilizes and reactivates protein aggregates in cooperation with DnaK/Hsp70 and its cofactors. The ClpB/Hsp104 protomer has two AAA+ modules, AAA-1 and AAA-2, and forms a homohexamer. In the hexamer, these modules form a two-tiered ring in which each tier consists of homotypic AAA+ modules. By ATP binding and its hydrolysis at these AAA+ modules, ClpB/Hsp104 exerts the mechanical power required for protein disaggregation. Although ATPase cycle of this chaperone has been studied by several groups, an integrated understanding of this cycle has not been obtained because of the complexity of the mechanism and differences between species. To improve our understanding of the ATPase cycle, we prepared many ordered heterohexamers of ClpB from Thermus thermophilus, in which two subunits having different mutations were cross-linked to each other and arranged alternately and measured their nucleotide binding, ATP hydrolysis, and disaggregation abilities. The results indicated that the ATPase cycle of ClpB proceeded as follows: (i) the 12 AAA+ modules randomly bound ATP, (ii) the binding of four or more ATP to one AAA+ ring was sensed by a conserved Arg residue and converted another AAA+ ring into the ATPase-active form, and (iii) ATP hydrolysis occurred cooperatively in each ring. We also found that cooperative ATP hydrolysis in at least one ring was needed for the disaggregation activity of ClpB. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. 3 CFR - Establishing a Working Group on the Intersection of HIV/AIDS, Violence Against Women and Girls...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... prevention activities that engage men and boys and highlight their role in the prevention of violence against... research (disaggregated by sex, gender, and gender identity, where practicable); and (v) existing...

  5. 77 FR 20277 - Establishing a Working Group on the Intersection of HIV/AIDS, Violence Against Women and Girls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ...; (iv) emphasizing evidence-based prevention activities that engage men and boys and highlight their... more comprehensive data and targeted research (disaggregated by sex, gender, and gender identity, where...

  6. Quantifying and Disaggregating Consumer Purchasing Behavior for Energy Systems Modeling

    EPA Science Inventory

    Consumer behaviors such as energy conservation, adoption of more efficient technologies, and fuel switching represent significant potential for greenhouse gas mitigation. Current efforts to model future energy outcomes have tended to use simplified economic assumptions ...

  7. MetNetMaker: a free and open-source tool for the creation of novel metabolic networks in SBML format.

    PubMed

    Forth, Thomas; McConkey, Glenn A; Westhead, David R

    2010-09-15

    An application has been developed to help with the creation and editing of Systems Biology Markup Language (SBML) format metabolic networks up to the organism scale. Networks are defined as a collection of Kyoto Encyclopedia of Genes and Genomes (KEGG) LIGAND reactions with an optional associated Enzyme Classification (EC) number for each reaction. Additional custom reactions can be defined by the user. Reactions within the network can be assigned flux constraints and compartmentalization is supported for each reaction in addition to the support for reactions that occur across compartment boundaries. Exported networks are fully SBML L2V4 compatible with an optional L2V1 export for compatibility with old versions of the COBRA toolbox. The software runs in the free Microsoft Access 2007 Runtime (Microsoft Inc.), which is included with the installer and works on Windows XP SP2 or better. Full source code is viewable in the full version of Access 2007 or 2010. Users must have a license to use the KEGG LIGAND database (free academic licensing is available). Please go to www.bioinformatics.leeds.ac.uk/~pytf/metnetmaker for software download, help and tutorials.

  8. Implementation and effectiveness of integrated trauma and addiction treatment for incarcerated men.

    PubMed

    Wolff, Nancy; Huening, Jessica; Shi, Jing; Frueh, B Christopher; Hoover, Donald R; McHugo, Gregory

    2015-03-01

    A controlled trial of Seeking Safety (SS) and Male-Trauma Recovery Empowerment Model (M-TREM) examined implementation and effectiveness of integrated group therapy for comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) on PTSD and mental health symptoms plus self-esteem and efficacy for incarcerated men. The study sample (n=230) was male inmates 18 years or older who were primarily non-white, high school graduates or equivalents, had childhood trauma histories, committed violent crimes, had serious mental illnesses, and resided in a maximum security prison. Incarcerated men, who screened positive for PTSD and SUD, were assigned randomly (n=142) or by preference (n=88) to receive SS or M-TREM, with a waitlist group of (n=93). Manualized interventions were group-administered for 14 weeks. Primary outcomes were PTSD and other mental health symptoms. Secondary outcomes were self-esteem, coping, and self-efficacy. SUD outcomes cannot be measured in a correctional setting. Implementation feasibility was exhibited by the ability to recruit, screen, assign, and retain participants. Effectiveness findings depended on sample, design, and method for analysis. Using a waitlist control group and no follow-up period, we found no aggregate effect of treatment on PTSD symptoms, although, when disaggregated, M-TREM was found to improve PTSD severity and SS improved general mental health symptoms and psychological functioning. Using intent-to-treat and completer analyses, no significant differences were found in the relative performance between SS and M-TREM on primary or secondary outcomes. When longitudinal data were maximized and modeled in ways that reflect the hierarchical nature of the data, we found that SS and M-TREM performed better than no treatment on PTSD severity and secondary outcomes, and that treatment benefits endured. Findings cautiously support implementing either Seeking Safety or M-TREM to treat incarcerated men with co-morbid PTSD and addiction problems. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Implementation and effectiveness of integrated trauma and addiction treatment for incarcerated men

    PubMed Central

    Wolff, Nancy; Huening, Jessica; Shi, Jing; Frueh, B. Christopher; Hoover, Donald R.; McHugo, Gregory

    2015-01-01

    A controlled trial of Seeking Safety (SS) and Male-Trauma Recovery Empowerment Model (M-TREM) examined implementation and effectiveness of integrated group therapy for comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) on PTSD and mental health symptoms plus self-esteem and efficacy for incarcerated men. The study sample (n = 230) was male inmates 18 years or older who were primarily non-white, high school graduates or equivalents, had childhood trauma histories, committed violent crimes, had serious mental illnesses, and resided in a maximum security prison. Incarcerated men, who screened positive for PTSD and SUD, were assigned randomly (n = 142) or by preference (n = 88) to receive SS or M-TREM, with a waitlist group of (n = 93). Manualized interventions were group-administered for 14 weeks. Primary outcomes were PTSD and other mental health symptoms. Secondary outcomes were self-esteem, coping, and self-efficacy. SUD outcomes cannot be measured in a correctional setting. Implementation feasibility was exhibited by the ability to recruit, screen, assign, and retain participants. Effectiveness findings depended on sample, design, and method for analysis. Using a waitlist control group and no follow-up period, we found no aggregate effect of treatment on PTSD symptoms, although, when disaggregated, M-TREM was found to improve PTSD severity and SS improved general mental health symptoms and psychological functioning. Using intent-to-treat and completer analyses, no significant differences were found in the relative performance between SS and M-TREM on primary or secondary outcomes. When longitudinal data were maximized and modeled in ways that reflect the hierarchical nature of the data, we found that SS and M-TREM performed better than no treatment on PTSD severity and secondary outcomes, and that treatment benefits endured. Findings cautiously support implementing either Seeking Safety or M-TREM to treat incarcerated men with co-morbid PTSD and addiction problems. PMID:25617774

  10. The effect of technology on student science achievement

    NASA Astrophysics Data System (ADS)

    Hilton, June Kraft

    2003-10-01

    Prior research indicates that technology has had little effect on raising student achievement. Little empirical research exists, however, studying the effects of technology as a tool to improve student achievement through development of higher order thinking skills. Also, prior studies have not focused on the manner in which technology is being used in the classroom and at home to enhance teaching and learning. Empirical data from a secondary school representative of those in California were analyzed to determine the effects of technology on student science achievement. The quantitative analysis methods for the school data study included a multiple linear path analysis, using final course grade as the ultimate exogenous variable. In addition, empirical data from a nationwide survey on how Americans use the Internet were disaggregated by age and analyzed to determine the relationships between computer and Internet experience and (a) Internet use at home for school assignments and (b) more general computer use at home for school assignments for school age children. Analysis of data collected from the a "A Nation Online" Survey conducted by the United States Census Bureau assessed these relationships via correlations and cross-tabulations. Finally, results from these data analyses were assessed in conjunction with systemic reform efforts from 12 states designed to address improvements in science and mathematics education in light of the Third International Mathematics and Science Survey (TIMSS). Examination of the technology efforts in those states provided a more nuanced understanding of the impact technology has on student achievement. Key findings included evidence that technology training for teachers increased their use of the computer for instruction but students' final science course grade did not improve; school age children across the country did not use the computer at home for such higher-order cognitive activities as graphics and design or spreadsheets/databases; and states whose systemic reform initiatives included a mix of capacity building and alignment to state standards realized improved student achievement on the 2000 NAEP Science Assessment.

  11. Characterize older driver behavior for traffic simulation and vehicle emission model.

    DOT National Transportation Integrated Search

    2012-05-01

    The use of traffic simulation models is becoming more widespread as a means of : assessing traffic, safety and environmental impacts as a result of infrastructure, control and : operational changes at disaggregate levels. It is imperative that these ...

  12. Best practices in nursing homes. Clinical supervision, management, and human resource practices.

    PubMed

    Dellefield, Mary Ellen

    2008-07-01

    Human resource practices including supervision and management are associated with organizational performance. Evidence supportive of such an association in nursing homes is found in the results of numerous research studies conducted during the past 17 years. In this article, best practices related to this topic have been culled from descriptive, explanatory, and intervention studies in a range of interdisciplinary research journals published between 1990 and 2007. Identified best practices include implementation of training programs on supervision and management for licensed nurses, certified nursing assistant job enrichment programs, implementation of consistent nursing assignments, and the use of electronic documentation. Organizational barriers and facilitators of these best practices are described. Copyright 2009, SLACK Incorporated.

  13. Assessing gendered roles in water decision-making in semi-arid regions through sex-disaggregated water data with UNESCO-WWAP gender toolkit

    NASA Astrophysics Data System (ADS)

    Miletto, Michela; Greco, Francesca; Belfiore, Elena

    2017-04-01

    Global climate change is expected to exacerbate current and future stresses on water resources from population growth and land use, and increase the frequency and severity of droughts and floods. Women are more vulnerable to the effects of climate change than men not only because they constitute the majority of the world's poor but also because they are more dependent for their livelihood on natural resources that are threatened by climate change. In addition, social, economic and political barriers often limit their coping capacity. Women play a key role in the provision, management and safeguarding of water, nonetheless, gender inequality in water management framework persists around the globe. Sharp data are essential to inform decisions and support effective policies. Disaggregating water data by sex is crucial to analyse gendered roles in the water realm and inform gender sensitive water policies in light of the global commitments to gender equality of Agenda 2030. In view of this scenario, WWAP has created an innovative toolkit for sex-disaggregated water data collection, as a result of a participatory work of more than 35 experts, part of the WWAP Working Group on Sex-Disaggregated Indicators (http://www.unesco.org/new/en/natural-sciences/environment/water/wwap/water-and-gender/un-wwap-working-group-on-gender-disaggregated-indicators/#c1430774). The WWAP toolkit contains four tools: the methodology (Seager J. WWAP UNESCO, 2015), set of key indicators, the guideline (Pangare V.,WWAP UNESCO, 2015) and a questionnaire for field survey. WWAP key gender-sensitive indicators address water resources management, aspects of water quality and agricultural uses, water resources governance and management, and investigate unaccounted labour in according to gender and age. Managing water resources is key for climate adaptation. Women are particularly sensitive to water quality and the health of water-dependent ecosystems, often source of food and job opportunities. Extreme climatic events like floods and droughts could severely impact the status of water resources and dependent ecosystems and the sustainability of household activities and local economies, given the absence of gender sensitive preparedness to hydrological and meteorological extremes. This paper describes the application of the WWAP Gender Toolkit to water data assessments in semi-arid region of the Stampriet transboundary aquifer shared by Botwana, Namibia and South Africa, in the framework of the "Groundwater Resources Governance in Transboundary Aquifers" - GGRETA project, led and executed by the UNESCO International Hydrological Programme (IHP), and financed by the Swiss Agency for Development and Cooperation (SDC). The tests in the field proved the reliability of WWAP gender toolkit and selected gender-sensitive indicators in the freshwater assessment. Further analysis could inform on the gaps and needs for climate adaptation practices. Field data identified socially-determined differences in roles, and confirmed the prevalent role of women in managing freshwater for drinking and sanitation purposes within the household boundaries, while decision-making for water allocation and use (with implications on hydrological risk) for agriculture and livestock purposes, is broadly under men's responsibility.

  14. Estimating intermittent individual spawning behavior via disaggregating group data

    EPA Science Inventory

    In order to understand fish biology and reproduction it is important to know the fecundity patterns of individual fish, as frequently established by recording the output of mixed-sex groups of fish in a laboratory setting. However, for understanding individual reproductive health...

  15. What have we learned about intelligent transportation systems?

    DOT National Transportation Integrated Search

    2000-12-01

    This study is concerned with what we have learned about ITS. But ITS is composed of many technologies and applications, some of which, it will be seen, are more successful than others. So, in a disaggregate manner, this study examines which ITS techn...

  16. Joint Cost, Production Technology and Output Disaggregation in Regulated Motor Carriers

    DOT National Transportation Integrated Search

    1978-11-01

    The study uses a sample of 252 Class I Instruction 27 Motor Carriers (Instruction 27 carriers earned at least 75 percent of their revenues from intercity transportation of general commodities over a three year period) of general freight that existed ...

  17. Data Warehousing: Beyond Disaggregation.

    ERIC Educational Resources Information Center

    Rudner, Lawrence M.; Boston, Carol

    2003-01-01

    Discusses data warehousing, which provides information more fully responsive to local, state, and federal data needs. Such a system allows educators to generate reports and analyses that supply information, provide accountability, explore relationships among different kinds of data, and inform decision-makers. (Contains one figure and eight…

  18. Creation of a retrospective job-exposure matrix using surrogate measures of exposure for a cohort of US career firefighters from San Francisco, Chicago and Philadelphia.

    PubMed

    Dahm, Matthew M; Bertke, Stephen; Allee, Steve; Daniels, Robert D

    2015-09-01

    To construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments. Departmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data were used to create a JEM based on standardised job titles and fire apparatus assignments using several surrogate exposure metrics to estimate firefighters' exposure to the combustion byproducts of fire. The metrics included duration of exposure (cumulative time with a standardised exposed job title and assignment), fire-runs (cumulative events of potential fire exposure) and time at fire (cumulative hours of potential fire exposure). The JEM consisted of 2298 unique job titles alongside 16,174 fire apparatus assignments from the three departments, which were collapsed into 15 standardised job titles and 15 standardised job assignments. Correlations were found between fire-runs and time at fires (Pearson coefficient=0.92), duration of exposure and time at fires (Pearson coefficient=0.85), and duration of exposure and fire-runs (Pearson coefficient=0.82). Total misclassification rates were found to be between 16-30% when using duration of employment as an exposure surrogate, which has been traditionally used in most epidemiological studies, compared with using the duration of exposure surrogate metric. The constructed JEM successfully differentiated firefighters based on gradient levels of potential exposure to the combustion byproducts of fire using multiple surrogate exposure metrics. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. Software for peak finding and elemental composition assignment for glycosaminoglycan tandem mass spectra.

    PubMed

    Hogan, John D; Klein, Joshua A; Wu, Jiandong; Chopra, Pradeep; Boons, Geert-Jan; Carvalho, Luis; Lin, Cheng; Zaia, Joseph

    2018-04-03

    Glycosaminoglycans (GAGs) covalently linked to proteoglycans (PGs) are characterized by repeating disaccharide units and variable sulfation patterns along the chain. GAG length and sulfation patterns impact disease etiology, cellular signaling, and structural support for cells. We and others have demonstrated the usefulness of tandem mass spectrometry (MS2) for assigning the structures of GAG saccharides; however, manual interpretation of tandem mass spectra is time-consuming, so computational methods must be employed. In the proteomics domain, the identification of monoisotopic peaks and charge states relies on algorithms that use averagine, or the average building block of the compound class being analyzed. While these methods perform well for protein and peptide spectra, they perform poorly on GAG tandem mass spectra, due to the fact that a single average building block does not characterize the variable sulfation of GAG disaccharide units. In addition, it is necessary to assign product ion isotope patterns in order to interpret the tandem mass spectra of GAG saccharides. To address these problems, we developed GAGfinder, the first tandem mass spectrum peak finding algorithm developed specifically for GAGs. We define peak finding as assigning experimental isotopic peaks directly to a given product ion composition, as opposed to deconvolution or peak picking, which are terms more accurately describing the existing methods previously mentioned. GAGfinder is a targeted, brute force approach to spectrum analysis that utilizes precursor composition information to generate all theoretical fragments. GAGfinder also performs peak isotope composition annotation, which is typically a subsequent step for averagine-based methods. Data are available via ProteomeXchange with identifier PXD009101. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

  20. Cigarette smoking and electronic cigarette vaping patterns as a function of e-cigarette flavourings.

    PubMed

    Litt, Mark D; Duffy, Valerie; Oncken, Cheryl

    2016-11-01

    The present study examined the influence of flavouring on the smoking and vaping behaviour of cigarette smokers asked to adopt e-cigarettes for a period of 6 weeks. Participants were 88 current male and female smokers with no intention to stop smoking, but who agreed to substitute e-cigarettes for their current cigarettes. On intake, participants were administered tests of taste and smell for e-cigarettes flavoured with tobacco, menthol, cherry and chocolate, and were given a refillable e-cigarette of their preferred flavour or a control flavour. Participants completed daily logs of cigarette and e-cigarette use and were followed each week. Analyses over days indicated that, during the 6-week e-cigarette period, cigarette smoking rates dropped from an average of about 16 to about 7 cigarettes/day. e-Cigarette flavour had a significant effect such that the largest drop in cigarette smoking occurred among those assigned menthol e-cigarettes, and the smallest drop in smoking occurred among those assigned chocolate and cherry flavours. e-Cigarette vaping rates also differed significantly by flavour assigned, with the highest vaping rates for tobacco- and cherry-flavoured e-cigarettes, and the lowest rates for those assigned to chocolate. The findings suggest that adoption of e-cigarettes in smokers may influence smoking rates and that e-cigarette flavourings can moderate this effect. e-Cigarette vaping rates are also influenced by flavourings. These findings may have implications for the utility of e-cigarettes as a nicotine replacement device and for the regulation of flavourings in e-cigarettes for harm reduction. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

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