Sample records for discovery function pursuant

  1. 24 CFR 26.42 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...

  2. 24 CFR 26.42 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...

  3. 24 CFR 26.42 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...

  4. 24 CFR 26.42 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...

  5. 24 CFR 26.42 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...

  6. 24 CFR 26.43 - Subpoenas.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.43 Subpoenas. (a) General... request for a subpoena in aid of discovery shall be filed in time to permit the conclusion of discovery 15...

  7. 47 CFR 65.105 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  8. 47 CFR 65.105 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  9. 47 CFR 65.105 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  10. 47 CFR 65.105 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  11. 47 CFR 65.105 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  12. 45 CFR 1386.103 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Discovery. 1386.103 Section 1386.103 Public... Hearing Procedures § 1386.103 Discovery. The Department and any party named in the Notice issued pursuant to § 1386.90 has the right to conduct discovery (including depositions) against opposing parties as...

  13. 45 CFR 1386.103 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Discovery. 1386.103 Section 1386.103 Public... Hearing Procedures § 1386.103 Discovery. The Department and any party named in the Notice issued pursuant to § 1386.90 has the right to conduct discovery (including depositions) against opposing parties as...

  14. 45 CFR 1386.103 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Discovery. 1386.103 Section 1386.103 Public... Hearing Procedures § 1386.103 Discovery. The Department and any party named in the Notice issued pursuant to § 1386.90 has the right to conduct discovery (including depositions) against opposing parties as...

  15. 45 CFR 1386.103 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Discovery. 1386.103 Section 1386.103 Public... Hearing Procedures § 1386.103 Discovery. The Department and any party named in the Notice issued pursuant to § 1386.90 has the right to conduct discovery (including depositions) against opposing parties as...

  16. 45 CFR 213.23a - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...

  17. 45 CFR 213.23a - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...

  18. 45 CFR 213.23a - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...

  19. 45 CFR 213.23a - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...

  20. 45 CFR 213.23a - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...

  1. 24 CFR 26.44 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HEARING PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.44 Protective... respect to discovery sought by an opposing party or with respect to the hearing, seeking to limit the..., or undue burden or expense because: (1) The discovery sought is unreasonably cumulative or...

  2. 49 CFR 511.36 - Motions to compel discovery.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... inspection or production of documents, or otherwise compelling discovery. For purposes of this subsection, an... a motion pursuant to § 511.31(d). When making oral examinations, the discovering party shall...

  3. 10 CFR 2.1018 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Discovery pursuant to §§ 2.1018(a)(2) and 2.1019 of this subpart shall begin after the issuance of the first... Presiding Officer shall protect against disclosure of the mental impressions, conclusions, opinions, or...

  4. 10 CFR 2.1018 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Discovery pursuant to §§ 2.1018(a)(2) and 2.1019 of this subpart shall begin after the issuance of the first... Presiding Officer shall protect against disclosure of the mental impressions, conclusions, opinions, or...

  5. 10 CFR 2.1018 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Discovery pursuant to §§ 2.1018(a)(2) and 2.1019 of this subpart shall begin after the issuance of the first... Presiding Officer shall protect against disclosure of the mental impressions, conclusions, opinions, or...

  6. 40 CFR 22.52 - Information exchange and discovery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Procedure Act § 22.52 Information exchange and discovery. Respondent's information exchange pursuant to § 22.19(a) shall include information on any economic benefit resulting from any activity or failure to act... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Information exchange and discovery. 22...

  7. 43 CFR 4.1135 - Motion to compel discovery.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... a motion made pursuant to this section, the administrative law judge may make such a protective... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Motion to compel discovery. 4.1135 Section... Motion to compel discovery. (a) If a deponent fails to answer a question propounded, or a party upon whom...

  8. 43 CFR 4.1135 - Motion to compel discovery.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... a motion made pursuant to this section, the administrative law judge may make such a protective... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Motion to compel discovery. 4.1135 Section... Motion to compel discovery. (a) If a deponent fails to answer a question propounded, or a party upon whom...

  9. 29 CFR 18.21 - Motion to compel discovery.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2011-07-01 2011-07-01 false Motion to compel discovery. 18.21 Section 18.21 Labor...

  10. 29 CFR 18.21 - Motion to compel discovery.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2012-07-01 2012-07-01 false Motion to compel discovery. 18.21 Section 18.21 Labor...

  11. 29 CFR 18.21 - Motion to compel discovery.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2013-07-01 2013-07-01 false Motion to compel discovery. 18.21 Section 18.21 Labor...

  12. 29 CFR 18.21 - Motion to compel discovery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.21 Motion to compel discovery. (a) If a deponent fails... to answer or respond. (d) In ruling on a motion made pursuant to this section, the administrative law... 29 Labor 1 2014-07-01 2013-07-01 true Motion to compel discovery. 18.21 Section 18.21 Labor Office...

  13. 40 CFR 164.51 - Other discovery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Other discovery. 164.51 Section 164.51... GOVERNING HEARINGS, UNDER THE FEDERAL INSECTICIDE, FUNGICIDE, AND RODENTICIDE ACT, ARISING FROM REFUSALS TO... OTHER HEARINGS CALLED PURSUANT TO SECTION 6 OF THE ACT General Rules of Practice Concerning Proceedings...

  14. 77 FR 41997 - Privacy Act of 1974; Notice of a New System of Records, Office of General Counsel E-Discovery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-17

    ... of a New System of Records, Office of General Counsel E-Discovery Management System AGENCY: Office of... Management System. SUMMARY: Pursuant to the provision of the Privacy Act of 1974, as amended (5 U.S.C. 552a... new system of records for the Office of General Counsel (OGC) E-Discovery Management System (EDMS...

  15. 21 CFR 1301.74 - Other security controls for non-practitioners; narcotic treatment programs and compounders for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... controlled substances within one business day of discovery of the theft or loss. The supplier is responsible... selected pursuant to paragraph (e) of this section, within one business day of discovery of such theft or... of business; (2) The specific controlled substances lost; (3) Whether the loss of the controlled...

  16. 21 CFR 1301.74 - Other security controls for non-practitioners; narcotic treatment programs and compounders for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... controlled substances within one business day of discovery of the theft or loss. The supplier is responsible... selected pursuant to paragraph (e) of this section, within one business day of discovery of such theft or... of business; (2) The specific controlled substances lost; (3) Whether the loss of the controlled...

  17. 16 CFR 3.36 - Applications for subpoenas for records of or appearances by certain officials or employees of the...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Discovery; Compulsory Process § 3.36 Applications for subpoenas for... application for records pursuant to § 4.11 of this chapter or the Freedom of Information Act may be filed with... sought is reasonable in scope; (2) If for purposes of discovery, the material falls within the limits of...

  18. 10 CFR 2.1018 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... pursuant to §§ 2.1018(a)(2) and 2.1019 of this subpart shall begin after the issuance of the first pre... Officer shall protect against disclosure of the mental impressions, conclusions, opinions, or legal...

  19. 10 CFR 2.1018 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... pursuant to §§ 2.1018(a)(2) and 2.1019 of this subpart shall begin after the issuance of the first pre... Officer shall protect against disclosure of the mental impressions, conclusions, opinions, or legal...

  20. 75 FR 11197 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Pistoia Alliance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ...; CambridgeSoft, San Diego, CA; Merck, Boston, MA; Collaborative Drug Discovery, Burlingame, CA; Royal Society of Chemistry, Cambridge, UNITED KINGDOM; Thomson Reuters HealthCare and Science, Philadelphia, PA...

  1. 76 FR 77029 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... statement made pursuant to section 19(a) or in the first report to shareholders following the discovery of... impression of fund gains. Based on a review of filings made with the Commission, the staff estimates that...

  2. 7 CFR 283.26 - Request that appeals be handled under procedures in subpart B for appeals of QC claims of $50,000...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD... date established for the conclusion of any discovery pursuant to § 283.29, a motion that its appeal be...

  3. 47 CFR 1.251 - Summary decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... an attachment to pleadings filed by him pursuant to paragraph (b) of this section. (b) Within 14 days... or memoranda of law. The presiding officer, giving appropriate weight to the nature of the proceeding... decision to the extent that the pleadings, affidavits, materials obtained by discovery or otherwise...

  4. 40 CFR 164.70 - Subpoenas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... witnesses or the production of documentary evidence may, by subpoena, be required at any designated place of... involved in the hearing or that the sought discovery pursuant to § 164.51 meets the standards set forth...) Motion for subpoena duces tecum. Subpoenas for the production of documentary evidence, unless issued by...

  5. 47 CFR 1.325 - Discovery and production of documents and things for inspection, copying, or photographing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... with the presiding officer): (i) All formation and organizational documents, including articles of..., minority/female status, and the like; (xi) All documents relating to commitments to divest other media... exchanged pursuant to the Standardized Document Production Order, the following information must also be...

  6. 47 CFR 1.325 - Discovery and production of documents and things for inspection, copying, or photographing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... with the presiding officer): (i) All formation and organizational documents, including articles of..., minority/female status, and the like; (xi) All documents relating to commitments to divest other media... exchanged pursuant to the Standardized Document Production Order, the following information must also be...

  7. 12 CFR 308.10 - Filing of papers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Filing of papers. 308.10 Section 308.10 Banks... AND PROCEDURE Uniform Rules of Practice and Procedure § 308.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents produced in response to a discovery request pursuant to...

  8. 12 CFR 308.10 - Filing of papers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Filing of papers. 308.10 Section 308.10 Banks... AND PROCEDURE Uniform Rules of Practice and Procedure § 308.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents produced in response to a discovery request pursuant to...

  9. 77 FR 2737 - Center for Scientific Review; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... Panel; Drug Discovery for the Nervous System. Date: January 27, 2012. Time: 1 p.m. to 3 p.m. Agenda: To... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U...

  10. 77 FR 33751 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... Discovery for the Nervous System. Date: June 28, 2012. Time: 1:30 p.m. to 4:30 p.m. Agenda: To review and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

  11. 40 CFR 255.1 - Scope and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waste management services pursuant to section 4002(a) of the Solid Waste Disposal Act, as amended by the... guidelines are applicable to policies, procedures, and criteria for the identification of those areas which... identification of which functions will be carried out by which agencies pursuant to section 4006 of the Act. (b...

  12. 40 CFR 255.1 - Scope and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... waste management services pursuant to section 4002(a) of the Solid Waste Disposal Act, as amended by the... guidelines are applicable to policies, procedures, and criteria for the identification of those areas which... identification of which functions will be carried out by which agencies pursuant to section 4006 of the Act. (b...

  13. 12 CFR 4.39 - Notification of parties and procedures for sharing and using OCC records in litigation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OCC information obtained pursuant to § 4.15, to the other parties. (c) Retrieval and destruction of... CURRENCY, DEPARTMENT OF THE TREASURY ORGANIZATION AND FUNCTIONS, AVAILABILITY AND RELEASE OF INFORMATION... promptly notify other parties to a case of the release of non-public OCC information obtained pursuant to...

  14. 47 CFR 59.2 - Terms and conditions of infrastructure sharing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... infrastructure, technology, information, or telecommunications facilities, or functions made available to a... infrastructure, technology, information, and telecommunications facilities, or functions available to a... infrastructure, technology, information and telecommunications facilities and functions pursuant to this part. ...

  15. 20 CFR 422.1 - Organization and functions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....1 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Organization and Functions of the Social Security Administration § 422.1 Organization and functions. (a) General. A complete description of the organization and functions of the Social Security Administration (pursuant to 5 U.S.C. 552...

  16. 20 CFR 422.1 - Organization and functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....1 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Organization and Functions of the Social Security Administration § 422.1 Organization and functions. (a) General. A complete description of the organization and functions of the Social Security Administration (pursuant to 5 U.S.C. 552...

  17. 47 CFR 69.603 - Association functions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Association functions. 69.603 Section 69.603... Exchange Carrier Association § 69.603 Association functions. (a) The Association shall not engage in any... with association functions pursuant to § 69.603 (c)-(g), and those expenses that pertain to Commission...

  18. Computational functional genomics-based approaches in analgesic drug discovery and repurposing.

    PubMed

    Lippmann, Catharina; Kringel, Dario; Ultsch, Alfred; Lötsch, Jörn

    2018-06-01

    Persistent pain is a major healthcare problem affecting a fifth of adults worldwide with still limited treatment options. The search for new analgesics increasingly includes the novel research area of functional genomics, which combines data derived from various processes related to DNA sequence, gene expression or protein function and uses advanced methods of data mining and knowledge discovery with the goal of understanding the relationship between the genome and the phenotype. Its use in drug discovery and repurposing for analgesic indications has so far been performed using knowledge discovery in gene function and drug target-related databases; next-generation sequencing; and functional proteomics-based approaches. Here, we discuss recent efforts in functional genomics-based approaches to analgesic drug discovery and repurposing and highlight the potential of computational functional genomics in this field including a demonstration of the workflow using a novel R library 'dbtORA'.

  19. 75 FR 63225 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... Change Regarding Anti-Internalization Functionality for NASDAQ OMX PSX October 6, 2010. Pursuant to...-internalization functionality on NASDAQ OMX PSX (``PSX''). The text of the proposed rule change is available from...- internalization function for the PSX System. Under the proposal, market participants entering orders under a...

  20. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource.

    PubMed

    Shim, Hongseok; Kim, Ji Hyun; Kim, Chan Yeong; Hwang, Sohyun; Kim, Hyojin; Yang, Sunmo; Lee, Ji Eun; Lee, Insuk

    2016-11-16

    Whole exome sequencing (WES) accelerates disease gene discovery using rare genetic variants, but further statistical and functional evidence is required to avoid false-discovery. To complement variant-driven disease gene discovery, here we present function-driven disease gene discovery in zebrafish (Danio rerio), a promising human disease model owing to its high anatomical and genomic similarity to humans. To facilitate zebrafish-based function-driven disease gene discovery, we developed a genome-scale co-functional network of zebrafish genes, DanioNet (www.inetbio.org/danionet), which was constructed by Bayesian integration of genomics big data. Rigorous statistical assessment confirmed the high prediction capacity of DanioNet for a wide variety of human diseases. To demonstrate the feasibility of the function-driven disease gene discovery using DanioNet, we predicted genes for ciliopathies and performed experimental validation for eight candidate genes. We also validated the existence of heterozygous rare variants in the candidate genes of individuals with ciliopathies yet not in controls derived from the UK10K consortium, suggesting that these variants are potentially involved in enhancing the risk of ciliopathies. These results showed that an integrated genomics big data for a model animal of diseases can expand our opportunity for harnessing WES data in disease gene discovery. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  1. 45 CFR 5b.2 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.2... Federal functions, such as intermediaries and carriers performing functions under contracts and agreements... year) or intermittent services have been procured by the Department by contract pursuant to 3109 of...

  2. 28 CFR 0.111 - General functions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (b) The service of all civil and criminal process emanating from the Federal judicial system... psychological well-being and social adjustment of such persons, pursuant to 18 U.S.C. 3521, et seq., and... intimidation impedes the functioning of the Federal judicial process. (f) Provision of assistance in the...

  3. 78 FR 28275 - Delegation of Authority to the Comptroller of Certain Authorities Regarding Debt Collection and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ...); the Office of Management and Budget's Determination with Respect to Transfer of Functions Pursuant to..., functions and responsibilities for the administrative collection, compromise, suspension, termination of Department collection, advance decision, settlement, and waiver of claims of or against debtors of the...

  4. 19 CFR 201.4 - Performance of functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Performance of functions. 201.4 Section 201.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION... of 1930, or (2) a matter under an investigation pursuant to section 202 of the Trade Act of 1974 (19...

  5. 19 CFR 201.4 - Performance of functions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Performance of functions. 201.4 Section 201.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION... of 1930, or (2) a matter under an investigation pursuant to section 202 of the Trade Act of 1974 (19...

  6. 19 CFR 201.4 - Performance of functions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Performance of functions. 201.4 Section 201.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION... of 1930, or (2) a matter under an investigation pursuant to section 202 of the Trade Act of 1974 (19...

  7. 19 CFR 201.4 - Performance of functions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Performance of functions. 201.4 Section 201.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION... of 1930, or (2) a matter under an investigation pursuant to section 202 of the Trade Act of 1974 (19...

  8. 19 CFR 201.4 - Performance of functions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Performance of functions. 201.4 Section 201.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION... of 1930, or (2) a matter under an investigation pursuant to section 202 of the Trade Act of 1974 (19...

  9. 75 FR 80870 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing and Order Granting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... Proposed Rule Change To Eliminate the Validated Cross Trade Entry Functionality December 16, 2010. Pursuant... eliminate the Validated Cross Trade Entry Functionality for Exchange-registered Institutional Brokers. The... Brokers (``Institutional Brokers'') by eliminating the ability of an Institutional Broker to execute...

  10. 76 FR 10595 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... engage in real estate settlement servicing; trust company functions; tax planning and tax preparation..., Milwaukee, Wisconsin, and thereby engage in real estate settlement servicing; trust company functions; tax planning and tax preparation services, pursuant to sections 225.28(b)(2), (b)(5), and (b)(6) of Regulation...

  11. 15 CFR 30.72 - Civil penalty procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... hearing before an administrative law judge. Any such hearing shall be conducted in accordance with 5 U.S.C. 556 and 557. (b) Applicable law for delegated function. If, pursuant to 13 U.S.C. 306, the Secretary delegates functions addressed in this part to another agency, the provisions of law of that agency relating...

  12. 48 CFR 915.404-4 - Profit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) and Bonneville Power Administration (BPA) functions. Pursuant to section 602(d) (13) and (20) of the... as those of the BPA, now being performed by DOE are exempt from the 6 percent of cost restriction on...

  13. 48 CFR 915.404-4 - Profit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) and Bonneville Power Administration (BPA) functions. Pursuant to section 602(d) (13) and (20) of the... as those of the BPA, now being performed by DOE are exempt from the 6 percent of cost restriction on...

  14. 48 CFR 915.404-4 - Profit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) and Bonneville Power Administration (BPA) functions. Pursuant to section 602(d) (13) and (20) of the... as those of the BPA, now being performed by DOE are exempt from the 6 percent of cost restriction on...

  15. 48 CFR 915.404-4 - Profit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) and Bonneville Power Administration (BPA) functions. Pursuant to section 602(d) (13) and (20) of the... as those of the BPA, now being performed by DOE are exempt from the 6 percent of cost restriction on...

  16. 48 CFR 915.404-4 - Profit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) and Bonneville Power Administration (BPA) functions. Pursuant to section 602(d) (13) and (20) of the... as those of the BPA, now being performed by DOE are exempt from the 6 percent of cost restriction on...

  17. 47 CFR 73.1820 - Station log.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... part. (iii) An entry of each test and activation of the Emergency Alert System (EAS) pursuant to the... functions may be utilized to record entries in the station log Provided: (1) The recording devices do not...

  18. 28 CFR 0.45 - General functions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... industry pursuant to the Military Selective Service Act of 1967 (50 U.S.C., App. 459); reparations suits... States for penalties for violations of car service orders (49 U.S.C. 1(17a)); actions restraining...

  19. RNA interference for functional genomics and improvement of cotton (Gossypium species)

    USDA-ARS?s Scientific Manuscript database

    RNA interference (RNAi), is a powerful new technology in the discovery of genetic sequence functions, and has become a valuable tool for functional genomics of cotton (Gossypium ssp.). The rapid adoption of RNAi has replaced previous antisense technology. RNAi has aided in the discovery of function ...

  20. 75 FR 7628 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Joint Venture...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... nanocomposites, nanocrystals dispersed in polymers, to create materials with enhanced performance and new functionality that cannot be provided by polymers or traditional composites. Patricia A. Brink, Deputy Director...

  1. 76 FR 9616 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Delete the Text of Rule 1500, Which Governs MatchPoint's Functionality February 11, 2011. Pursuant to... the text of Rule 1500, which governs MatchPoint's functionality. The text of the proposed rule change... the proposed rule change. The text of those statements may be examined at the places specified in Item...

  2. 76 FR 49764 - Information Collection Request Extension Submitted to the Office of Management and Budget (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ... its APD to properly perform its function of marketing a limited amount of Federal hydropower. Western... the Federal reclamation program.\\4\\ The basic principle of the Reclamation Act of 1902 was the United... the power marketing functions from the Department of the Interior to Western.\\10\\ Pursuant to this...

  3. 47 CFR 0.111 - Functions of the Bureau.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Engineering and Technology has shared responsibility for radiofrequency equipment and device complaints. (5...); subpart C (Federal-State/Local Relationships [Reserved]; subpart D (carriage of television broadcast... information, conduct investigations, conduct external audits and collect information, including pursuant to...

  4. 76 FR 6461 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... 01/28/2011 pursuant to 40 CFR 1506.9. Notice In accordance with Section 309(a) of the Clean Air Act..., Revised Final EIS, USACE, FL, C-111 Spreader Canal Western Project, To Restore Ecosystem Function in...

  5. Rethinking the Discovery Function of Proof within the Context of Proofs and Refutations

    ERIC Educational Resources Information Center

    Komatsu, Kotaro; Tsujiyama, Yosuke; Sakamaki, Aruta

    2014-01-01

    Proof and proving are important components of school mathematics and have multiple functions in mathematical practice. Among these functions of proof, this paper focuses on the discovery function that refers to invention of a new statement or conjecture by reflecting on or utilizing a constructed proof. Based on two cases in which eighth and ninth…

  6. Research & market strategy: how choice of drug discovery approach can affect market position.

    PubMed

    Sams-Dodd, Frank

    2007-04-01

    In principal, drug discovery approaches can be grouped into target- and function-based, with the respective aims of developing either a target-selective drug or a drug that produces a specific biological effect irrespective of its mode of action. Most analyses of drug discovery approaches focus on productivity, whereas the strategic implications of the choice of drug discovery approach on market position and ability to maintain market exclusivity are rarely considered. However, a comparison of approaches from the perspective of market position indicates that the functional approach is superior for the development of novel, innovative treatments.

  7. 40 CFR 90.708 - Cumulative Sum (CumSum) procedure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... is 5.0×σ, and is a function of the standard deviation, σ. σ=is the sample standard deviation and is... individual engine. FEL=Family Emission Limit (the standard if no FEL). F=.25×σ. (2) After each test pursuant...

  8. 19 CFR 115.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS General § 115.3... carry out the functions of this part and which he designates to certify containers and road vehicles for...

  9. 19 CFR 115.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS General § 115.3... carry out the functions of this part and which he designates to certify containers and road vehicles for...

  10. 19 CFR 115.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS General § 115.3... carry out the functions of this part and which he designates to certify containers and road vehicles for...

  11. 19 CFR 115.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS General § 115.3... carry out the functions of this part and which he designates to certify containers and road vehicles for...

  12. 19 CFR 115.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS General § 115.3... carry out the functions of this part and which he designates to certify containers and road vehicles for...

  13. 78 FR 35650 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... this new AIM feature will function as described in rule filing SR-CBOE-2013- 048. B. Self-Regulatory... the necessary system work and perform sufficient testing to ensure that this new AIM feature functions... Effectiveness of a Proposed Rule Change Relating to Rule 6.74A June 7, 2013. Pursuant to Section 19(b)(1) of the...

  14. 40 CFR 110.5 - Discharges of oil not determined “as may be harmful” pursuant to Section 311(b)(3) of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... functioning vessel engine (including an engine on a public vessel) and any discharges of such oil accumulated... connection with research, demonstration projects, or studies relating to the prevention, control, or...

  15. 40 CFR 110.5 - Discharges of oil not determined “as may be harmful” pursuant to Section 311(b)(3) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... functioning vessel engine (including an engine on a public vessel) and any discharges of such oil accumulated... connection with research, demonstration projects, or studies relating to the prevention, control, or...

  16. 40 CFR 110.5 - Discharges of oil not determined “as may be harmful” pursuant to Section 311(b)(3) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... functioning vessel engine (including an engine on a public vessel) and any discharges of such oil accumulated... connection with research, demonstration projects, or studies relating to the prevention, control, or...

  17. 40 CFR 110.5 - Discharges of oil not determined “as may be harmful” pursuant to Section 311(b)(3) of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... functioning vessel engine (including an engine on a public vessel) and any discharges of such oil accumulated... connection with research, demonstration projects, or studies relating to the prevention, control, or...

  18. Ligand-based receptor tyrosine kinase partial agonists: New paradigm for cancer drug discovery?

    PubMed

    Riese, David J

    2011-02-01

    INTRODUCTION: Receptor tyrosine kinases (RTKs) are validated targets for oncology drug discovery and several RTK antagonists have been approved for the treatment of human malignancies. Nonetheless, the discovery and development of RTK antagonists has lagged behind the discovery and development of agents that target G-protein coupled receptors. In part, this is because it has been difficult to discover analogs of naturally-occurring RTK agonists that function as antagonists. AREAS COVERED: Here we describe ligands of ErbB receptors that function as partial agonists for these receptors, thereby enabling these ligands to antagonize the activity of full agonists for these receptors. We provide insights into the mechanisms by which these ligands function as antagonists. We discuss how information concerning these mechanisms can be translated into screens for novel small molecule- and antibody-based antagonists of ErbB receptors and how such antagonists hold great potential as targeted cancer chemotherapeutics. EXPERT OPINION: While there have been a number of important key findings into this field, the identification of the structural basis of ligand functional specificity is still of the greatest importance. While it is true that, with some notable exceptions, peptide hormones and growth factors have not proven to be good platforms for oncology drug discovery; addressing the fundamental issues of antagonistic partial agonists for receptor tyrosine kinases has the potential to steer oncology drug discovery in new directions. Mechanism based approaches are now emerging to enable the discovery of RTK partial agonists that may antagonize both agonist-dependent and -independent RTK signaling and may hold tremendous promise as targeted cancer chemotherapeutics.

  19. Chemical Discovery

    ERIC Educational Resources Information Center

    Brown, Herbert C.

    1974-01-01

    The role of discovery in the advance of the science of chemistry and the factors that are currently operating to handicap that function are considered. Examples are drawn from the author's work with boranes. The thesis that exploratory research and discovery should be encouraged is stressed. (DT)

  20. 47 CFR 2.1093 - Radiofrequency radiation exposure evaluation: portable devices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Cellular Radiotelephone Service pursuant to part 22 of this chapter; the Personal Communications Service (PCS) pursuant to part 24 of this chapter; the Satellite Communications Services pursuant to part 25 of this chapter; the Miscellaneous Wireless Communications Services pursuant to part 27 of this chapter...

  1. 76 FR 75939 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... Growth Capital, Inc. a Georgia Corporation, to function as a small business investment company under the Small Business Investment Company License No. 04045251 issued to First Growth Capital, Inc., on December...

  2. 77 FR 32167 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant... Across America, L.P. a Delaware limited partnership, to function as a small business investment company under the Small Business Investment Company License No. 04040273 issued to Capital Across America, on...

  3. 77 FR 12640 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... Investment Partners, L.P. a Kentucky limited partnership, to function as a small business investment company under the Small Business Investment Company License No. 04/74-0283 issued to Prosperitas Investment...

  4. 77 FR 37089 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... SBIC, LLC, a Delaware limited liability company, to function as a small business investment company under the Small Business Investment Company License No. 07070100 issued to Berthel SBIC, LLC, on May 4...

  5. 77 FR 32167 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... Delaware limited partnership, to function as a small business investment company under the Small Business Investment Company License No. 02720594 issued to LV Equity Partners SBIC, on August 25, 1999 and said...

  6. 32 CFR 169.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... performance by DoD personnel. Core Logistics. Those functions identified as core logistics activities pursuant... 10 that are necessary to maintain a logistics capability (including personnel, equipment, and...; and labor surplus area set-asides and awards made under Pub. L. 85-536, section 8(a) and Pub. L. 95...

  7. 24 CFR 3500.21 - Mortgage servicing transfers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... (a) Definitions. As used in this section: Master servicer means the owner of the right to perform... this section. Subservicer means a servicer who does not own the right to perform servicing, but who... obtain the right to perform servicing functions pursuant to an agreement or understanding. Transferor...

  8. 24 CFR 3500.21 - Mortgage servicing transfers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... (a) Definitions. As used in this section: Master servicer means the owner of the right to perform... this section. Subservicer means a servicer who does not own the right to perform servicing, but who... obtain the right to perform servicing functions pursuant to an agreement or understanding. Transferor...

  9. 75 FR 60830 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant to the authority granted to the United States Small Business Administration under the Small Business...

  10. Web service discovery among large service pools utilising semantic similarity and clustering

    NASA Astrophysics Data System (ADS)

    Chen, Fuzan; Li, Minqiang; Wu, Harris; Xie, Lingli

    2017-03-01

    With the rapid development of electronic business, Web services have attracted much attention in recent years. Enterprises can combine individual Web services to provide new value-added services. An emerging challenge is the timely discovery of close matches to service requests among large service pools. In this study, we first define a new semantic similarity measure combining functional similarity and process similarity. We then present a service discovery mechanism that utilises the new semantic similarity measure for service matching. All the published Web services are pre-grouped into functional clusters prior to the matching process. For a user's service request, the discovery mechanism first identifies matching services clusters and then identifies the best matching Web services within these matching clusters. Experimental results show that the proposed semantic discovery mechanism performs better than a conventional lexical similarity-based mechanism.

  11. 21 CFR 20.114 - Data and information submitted pursuant to cooperative quality assurance agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Records § 20.114 Data and information submitted pursuant to cooperative quality assurance agreements. Data and information submitted to the Food and Drug Administration pursuant to a cooperative quality... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Data and information submitted pursuant to...

  12. 21 CFR 20.114 - Data and information submitted pursuant to cooperative quality assurance agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Records § 20.114 Data and information submitted pursuant to cooperative quality assurance agreements. Data and information submitted to the Food and Drug Administration pursuant to a cooperative quality... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Data and information submitted pursuant to...

  13. 21 CFR 20.114 - Data and information submitted pursuant to cooperative quality assurance agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Records § 20.114 Data and information submitted pursuant to cooperative quality assurance agreements. Data and information submitted to the Food and Drug Administration pursuant to a cooperative quality... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Data and information submitted pursuant to...

  14. 21 CFR 20.114 - Data and information submitted pursuant to cooperative quality assurance agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Records § 20.114 Data and information submitted pursuant to cooperative quality assurance agreements. Data and information submitted to the Food and Drug Administration pursuant to a cooperative quality... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Data and information submitted pursuant to...

  15. 78 FR 41995 - Designation of an Individual Pursuant to Executive Order 13619

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of an Individual Pursuant... individual whose property and interests in property are blocked pursuant to Executive Order 13619 of July 11...: The designation by the Director of OFAC of the one individual named in this notice, pursuant to...

  16. 39 CFR 230.14 - Who owns the written or recorded notes, memoranda, reports, and transcriptions made pursuant to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., reports, and transcriptions made pursuant to an official investigation, audit, or review conducted by an... the written or recorded notes, memoranda, reports, and transcriptions made pursuant to an official..., reports, and transcriptions, whether written or recorded and made pursuant to an official investigation...

  17. 76 FR 623 - Proposed Information Collection (Equal Opportunity Compliance Review Report) Activity: Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ..., Department of Veterans Affairs. ACTION: Notice. SUMMARY: The Veterans Benefits Administration (VBA... pursuant to Section 3506(c)(2)(A) of the PRA. With respect to the following collection of information, VBA... performance of VBA's functions, including whether the information will have practical utility; (2) the...

  18. 7 CFR 925.60 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF... necessary for the committee to perform its functions, each shipment of grapes as follows: (1) The name of... pursuant to which the grapes were handled. (b) Upon request of the committee, made with the approval of the...

  19. 7 CFR 925.60 - Reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF... necessary for the committee to perform its functions, each shipment of grapes as follows: (1) The name of... pursuant to which the grapes were handled. (b) Upon request of the committee, made with the approval of the...

  20. 77 FR 12641 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under...

  1. 77 FR 32167 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules And Regulations (13 CFR 107.1900) to function as a small business investment company under...

  2. 76 FR 2189 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under...

  3. 76 FR 23639 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant..., II, L.P., a Delaware Limited Partnership, to function as a small business investment company under the Small Business Investment Company License No. 09790400 issued to Aspen Ventures West, II, L.P., on...

  4. 77 FR 32167 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... Delaware limited partnership, to function as a small business investment company under the Small Business Investment Company License No. 03730213 issued to Women's Growth Capital Fund I, LLLP, on June 17, 1998 and...

  5. 77 FR 2600 - Revocation of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... SMALL BUSINESS ADMINISTRATION Revocation of License of Small Business Investment Company Pursuant... Limited Partnership, to function as a small business investment company under the Small Business Investment Company License No. 09790431 issued to AltoTech II, L.P. on December 04, 2000 and said license is...

  6. 78 FR 26680 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under...

  7. 78 FR 3496 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under...

  8. 40 CFR 117.11 - General applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-Scene Coordinator pursuant to 40 CFR part 1510 (the National Oil and Hazardous Substances Pollution Plan) or 33 CFR 153.10(e) (Pollution by Oil and Hazardous Substances) or in accordance with applicable... § 165.7 of Title 14 of the State of California Administrative Code; (g) From a properly functioning...

  9. 40 CFR 117.11 - General applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-Scene Coordinator pursuant to 40 CFR part 1510 (the National Oil and Hazardous Substances Pollution Plan) or 33 CFR 153.10(e) (Pollution by Oil and Hazardous Substances) or in accordance with applicable... § 165.7 of Title 14 of the State of California Administrative Code; (g) From a properly functioning...

  10. 40 CFR 117.11 - General applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-Scene Coordinator pursuant to 40 CFR part 1510 (the National Oil and Hazardous Substances Pollution Plan) or 33 CFR 153.10(e) (Pollution by Oil and Hazardous Substances) or in accordance with applicable... § 165.7 of Title 14 of the State of California Administrative Code; (g) From a properly functioning...

  11. 77 FR 73263 - Organization and Functions, and Seal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ... #0; #0;Rules and Regulations #0; Federal Register #0; #0; #0;This section of the FEDERAL REGISTER contains regulatory documents #0;having general applicability and legal effect, most of which are keyed #0;to and codified in the Code of Federal Regulations, which is published #0;under 50 titles pursuant to...

  12. 76 FR 19067 - Agency Information Collection Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... under established marketing plans, Western needs to be able to collect information to evaluate who will... Federal reclamation program.\\2\\ The basic principle of the Reclamation Act of 1902 was that the United... marketing functions of the Department of the Interior to Western.\\8\\ Pursuant to this authority, Western...

  13. 75 FR 14644 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Investment Act of 1958, under section 309 of the Act and section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  14. 76 FR 56864 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  15. 77 FR 2601 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  16. 77 FR 12641 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  17. 75 FR 9628 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  18. 75 FR 60830 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  19. 75 FR 41559 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... Investment Act of 1958, under section 309 of the Act and section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  20. 76 FR 1658 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  1. 77 FR 2600 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  2. 78 FR 4189 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  3. 76 FR 37167 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  4. 75 FR 77691 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  5. 78 FR 3496 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  6. 76 FR 8802 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  7. 78 FR 70617 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  8. 75 FR 41559 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... Investment Act of 1958, under section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  9. 77 FR 2601 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRTATION Surrender of License of Small Business Investment Company Pursuant...

  10. 76 FR 59480 - Surrender of License of Small Business Investment Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Investment Act of 1958, under Section 309 of the Act and Section 107.1900 of the Small Business Administration Rules and Regulations (13 CFR 107.1900) to function as a small business investment company under... SMALL BUSINESS ADMINISTRATION Surrender of License of Small Business Investment Company Pursuant...

  11. 28 CFR 0.95 - General functions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and personnel, pursuant to section 5003 of title 18 of the U.S. Code. (h) Conduct of studies and the preparation and submission of reports and recommendations to committing courts respecting disposition of cases... and prepare, or cause to be conducted and prepared, studies and submit reports to the court and the...

  12. 12 CFR 560.41 - Leasing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... savings association may exercise its authority under HOLA sections 5(c)(1)(B) (residential real estate... functional equivalent of loans made under those HOLA sections. These activities are commonly referred to as... market value or book value. (d) General leasing. Pursuant to section 5(c)(2)(C) of the HOLA, a Federal...

  13. 10 CFR 215.4 - Production of contracts and documents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... function of the Administrator, he may require the production by any person of any agreement or document relating to foreign oil supply arrangements or reports related thereto. Such material shall be provided pursuant to the conditions prescribed by the Administrator at the time of such order or subsequently. As...

  14. 10 CFR 215.4 - Production of contracts and documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... function of the Administrator, he may require the production by any person of any agreement or document relating to foreign oil supply arrangements or reports related thereto. Such material shall be provided pursuant to the conditions prescribed by the Administrator at the time of such order or subsequently. As...

  15. 77 FR 61418 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group Function, Integration, and... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...

  16. 22 CFR 8.2 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Policy. 8.2 Section 8.2 Foreign Relations... solely for advisory functions and any decision taken pursuant to the advice or recommendation of an... advisory committees will be open to the public unless there is a compelling reason which requires...

  17. 75 FR 68376 - Notice of Proposed Information Collection for 1029-0114

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... to collect information for a series of customer surveys to evaluate OSM's performance in meeting the performance goals outlined in its annual plans developed pursuant to the Government Performance and Results... the performance of the functions of the agency; (2) the accuracy of the agency's burden estimates; (3...

  18. 47 CFR 1.115 - Application for review of action taken pursuant to delegated authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Application for review of action taken pursuant... Actions Taken by the Commission and Pursuant to Delegated Authority; Effective Dates and Finality Dates of Actions § 1.115 Application for review of action taken pursuant to delegated authority. (a) Any person...

  19. 47 CFR 1.115 - Application for review of action taken pursuant to delegated authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Application for review of action taken pursuant... Actions Taken by the Commission and Pursuant to Delegated Authority; Effective Dates and Finality Dates of Actions § 1.115 Application for review of action taken pursuant to delegated authority. (a) Any person...

  20. 47 CFR 1.115 - Application for review of action taken pursuant to delegated authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Application for review of action taken pursuant... Actions Taken by the Commission and Pursuant to Delegated Authority; Effective Dates and Finality Dates of Actions § 1.115 Application for review of action taken pursuant to delegated authority. (a) Any person...

  1. 47 CFR 1.115 - Application for review of action taken pursuant to delegated authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Application for review of action taken pursuant... Actions Taken by the Commission and Pursuant to Delegated Authority; Effective Dates and Finality Dates of Actions § 1.115 Application for review of action taken pursuant to delegated authority. (a) Any person...

  2. 29 CFR 1608.12 - Equal employment opportunity plans adopted pursuant to section 717 of title VII.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Equal employment opportunity plans adopted pursuant to... 1964, AS AMENDED § 1608.12 Equal employment opportunity plans adopted pursuant to section 717 of title VII. If adherence to an Equal Employment Opportunity Plan, adopted pursuant to section 717 of title...

  3. The Double-Edged Sword of Pedagogy: Instruction Limits Spontaneous Exploration and Discovery

    ERIC Educational Resources Information Center

    Bonawitz, Elizabeth; Shafto, Patrick; Gweon, Hyowon; Goodman, Noah D.; Spelke, Elizabeth; Schulz, Laura

    2011-01-01

    Motivated by computational analyses, we look at how teaching affects exploration and discovery. In Experiment 1, we investigated children's exploratory play after an adult pedagogically demonstrated a function of a toy, after an interrupted pedagogical demonstration, after a naive adult demonstrated the function, and at baseline. Preschoolers in…

  4. 17 CFR 249.325 - Form 13F, report of institutional investment manager pursuant to section 13(f) of the Securities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... institutional investment manager pursuant to section 13(f) of the Securities Exchange Act of 1934. 249.325... manager pursuant to section 13(f) of the Securities Exchange Act of 1934. This form shall be used by institutional investment managers which are required to furnish reports pursuant to section 13(f) of the...

  5. 78 FR 44142 - Modification of Two National Customs Automation Program (NCAP) Tests Concerning Automated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... efforts are accomplished through phased releases of ACE component functionality designed to introduce new... designed to evaluate planned components of the NCAP. This test is authorized pursuant to Sec. 101.9(b) of... import meat, poultry, or egg products or ``Samples for Laboratory Examination, Research, Evaluative...

  6. 12 CFR 4.39 - Notification of parties and procedures for sharing and using OCC records in litigation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CURRENCY, DEPARTMENT OF THE TREASURY ORGANIZATION AND FUNCTIONS, AVAILABILITY AND RELEASE OF INFORMATION... Information § 4.39 Notification of parties and procedures for sharing and using OCC records in litigation. (a... OCC information obtained pursuant to this subpart, and, upon entry of a protective order, shall...

  7. 12 CFR 4.39 - Notification of parties and procedures for sharing and using OCC records in litigation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CURRENCY, DEPARTMENT OF THE TREASURY ORGANIZATION AND FUNCTIONS, AVAILABILITY AND RELEASE OF INFORMATION... Information § 4.39 Notification of parties and procedures for sharing and using OCC records in litigation. (a... OCC information obtained pursuant to this subpart, and, upon entry of a protective order, shall...

  8. 12 CFR 4.39 - Notification of parties and procedures for sharing and using OCC records in litigation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CURRENCY, DEPARTMENT OF THE TREASURY ORGANIZATION AND FUNCTIONS, AVAILABILITY AND RELEASE OF INFORMATION... Information § 4.39 Notification of parties and procedures for sharing and using OCC records in litigation. (a... OCC information obtained pursuant to this subpart, and, upon entry of a protective order, shall...

  9. 77 FR 6130 - National Institute of Diabetes and Digestive and Kidney Diseases Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Diabetes and Digestive and Kidney Diseases Notice of Closed Meeting Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; Cellular Biology of Kidney Function and... Research; 93.849, Kidney Diseases, Urology and Hematology Research, National Institutes of Health, HHS...

  10. 45 CFR 155.740 - SHOP employer and employee eligibility appeals requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false SHOP employer and employee eligibility appeals... AFFORDABLE CARE ACT Exchange Functions: Small Business Health Options Program (SHOP) § 155.740 SHOP employer... that provides for the establishment of a SHOP pursuant to § 155.100 must provide an eligibility appeals...

  11. 45 CFR 155.740 - SHOP employer and employee eligibility appeals requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false SHOP employer and employee eligibility appeals... AFFORDABLE CARE ACT Exchange Functions: Small Business Health Options Program (SHOP) § 155.740 SHOP employer... that provides for the establishment of a SHOP pursuant to § 155.100 must provide an eligibility appeals...

  12. 78 FR 22899 - Certain Electronic Devices Having Placeshifting or Display Replication Functionality and Products...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-878] Certain Electronic Devices Having... pursuant to 19 U.S.C. 1337 AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given that a complaint was filed with the U.S. International Trade Commission on March 12, 2013...

  13. 75 FR 60170 - Proposed Information Collection (Disability Benefits Questionnaires) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... announcing an opportunity for public comment on the proposed collection of certain information by the agency... pursuant to Section 3506(c)(2)(A) of the PRA. With respect to the following collection of information, VBA... performance of VBA's functions, including whether the information will have practical utility; (2) the...

  14. 76 FR 71985 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... Institute of Child Health and Human Development Special Emphasis Group, Research on Children in Military Families: The Impact of Parental Military Deployment and Reintegration on Child and Family Functioning... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...

  15. 78 FR 9401 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; Beta-Cell Function and Cognition. Date...-5452, (301) 402-7172, [email protected] . Name of Committee: National Institute of Diabetes...

  16. 26 CFR 601.104 - Collection functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... amount of tax (or a minimum penalty) is, pursuant to statute, added to the tax unless the failure to file... to statute, added to the tax unless the failure to pay or deposit the tax due within the prescribed... methods—(1) Returns. Generally, an internal revenue tax assessment is based upon a return required by law...

  17. 26 CFR 601.104 - Collection functions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... amount of tax (or a minimum penalty) is, pursuant to statute, added to the tax unless the failure to file... to statute, added to the tax unless the failure to pay or deposit the tax due within the prescribed... methods—(1) Returns. Generally, an internal revenue tax assessment is based upon a return required by law...

  18. 26 CFR 601.104 - Collection functions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... amount of tax (or a minimum penalty) is, pursuant to statute, added to the tax unless the failure to file... to statute, added to the tax unless the failure to pay or deposit the tax due within the prescribed... methods—(1) Returns. Generally, an internal revenue tax assessment is based upon a return required by law...

  19. 26 CFR 601.104 - Collection functions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... amount of tax (or a minimum penalty) is, pursuant to statute, added to the tax unless the failure to file... to statute, added to the tax unless the failure to pay or deposit the tax due within the prescribed... methods—(1) Returns. Generally, an internal revenue tax assessment is based upon a return required by law...

  20. 26 CFR 601.104 - Collection functions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... amount of tax (or a minimum penalty) is, pursuant to statute, added to the tax unless the failure to file... to statute, added to the tax unless the failure to pay or deposit the tax due within the prescribed... methods—(1) Returns. Generally, an internal revenue tax assessment is based upon a return required by law...

  1. 75 FR 35076 - National Institute of Environmental Health Sciences; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... Branch, Division of Extramural Research and Training, Nat. Institute of Environmental Health Science, P.O... Environmental Health Sciences; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... Health Sciences Special Emphasis Panel, Pediatric Lung Function Study. Date: July 1, 2010. Time: 1 p.m...

  2. 77 FR 77160 - Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing of Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Liquidity Factor of CME's CDS Margin Methodology December 21, 2012. Pursuant to Section 19(b)(1) of the.... * * * * * CME CDS Liquidity Margin Factor Calculation Methodology The Liquidity Factor will be calculated as the... Liquidity Factor using the current Gross Notional Function with the following modifications: (1) the...

  3. 47 CFR 20.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... pending pursuant to section 332(c)(1)(B) of the Communications Act, 47 U.S.C. 332(c)(1)(B). A mobile... 47 Telecommunication 2 2012-10-01 2012-10-01 false Definitions. 20.3 Section 20.3... effectively available to a substantial portion of the public; or (b) The functional equivalent of such a...

  4. Extraction of consensus protein patterns in regions containing non-proline cis peptide bonds and their functional assessment.

    PubMed

    Exarchos, Konstantinos P; Exarchos, Themis P; Rigas, Georgios; Papaloukas, Costas; Fotiadis, Dimitrios I

    2011-05-10

    In peptides and proteins, only a small percentile of peptide bonds adopts the cis configuration. Especially in the case of amide peptide bonds, the amount of cis conformations is quite limited thus hampering systematic studies, until recently. However, lately the emerging population of databases with more 3D structures of proteins has produced a considerable number of sequences containing non-proline cis formations (cis-nonPro). In our work, we extract regular expression-type patterns that are descriptive of regions surrounding the cis-nonPro formations. For this purpose, three types of pattern discovery are performed: i) exact pattern discovery, ii) pattern discovery using a chemical equivalency set, and iii) pattern discovery using a structural equivalency set. Afterwards, using each pattern as predicate, we search the Eukaryotic Linear Motif (ELM) resource to identify potential functional implications of regions with cis-nonPro peptide bonds. The patterns extracted from each type of pattern discovery are further employed, in order to formulate a pattern-based classifier, which is used to discriminate between cis-nonPro and trans-nonPro formations. In terms of functional implications, we observe a significant association of cis-nonPro peptide bonds towards ligand/binding functionalities. As for the pattern-based classification scheme, the highest results were obtained using the structural equivalency set, which yielded 70% accuracy, 77% sensitivity and 63% specificity.

  5. Optogenetic Approaches to Drug Discovery in Neuroscience and Beyond.

    PubMed

    Zhang, Hongkang; Cohen, Adam E

    2017-07-01

    Recent advances in optogenetics have opened new routes to drug discovery, particularly in neuroscience. Physiological cellular assays probe functional phenotypes that connect genomic data to patient health. Optogenetic tools, in particular tools for all-optical electrophysiology, now provide a means to probe cellular disease models with unprecedented throughput and information content. These techniques promise to identify functional phenotypes associated with disease states and to identify compounds that improve cellular function regardless of whether the compound acts directly on a target or through a bypass mechanism. This review discusses opportunities and unresolved challenges in applying optogenetic techniques throughout the discovery pipeline - from target identification and validation, to target-based and phenotypic screens, to clinical trials. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  7. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  8. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  9. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  10. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  11. 12 CFR 4.39 - Notification of parties and procedures for sharing and using OCC records in litigation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CURRENCY, DEPARTMENT OF THE TREASURY ORGANIZATION AND FUNCTIONS, AVAILABILITY AND RELEASE OF INFORMATION... Information § 4.39 Notification of parties and procedures for sharing and using OCC records in litigation. (a... information obtained pursuant to this subpart, and, upon entry of a protective order, shall provide copies of...

  12. 75 FR 76768 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-63427; File No. SR-EDGA-2010-19] Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend EDGA Rule 11.9 To Offer Anti-Internalization Qualifier (``AIQ'') Functionality to Exchange Users December 3, 2010. Pursuant to Sectio...

  13. 75 FR 76763 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-63428; File No. SR-EDGX-2010-18] Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend EDGX Rule 11.9 To Offer Anti-Internalization Qualifier (``AIQ'') Functionality to Exchange Users December 3, 2010. Pursuant to Sectio...

  14. 77 FR 48192 - Self-Regulatory Organizations; Chicago Mercantile Exchange, Inc.; Notice of Filing of Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... Liquidity Factor of Its Credit Default Swap Margin Methodology August 7, 2012. Pursuant to Section 19(b)(1... model. The liquidity margin component of the CME CDS margin model is designed to capture the risk... CDS Clearing Member. The current methodology for the liquidity factor is a function of a portfolio's...

  15. 77 FR 35719 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... Change To Adopt Rules Related to Risk Management Functionality for BATS Options June 8, 2012. Pursuant to... serves an important risk management purpose, it operates consistent with the firm quote obligations of a... Change The Exchange proposes to adopt Rule 21.16, entitled ``Risk Monitor Mechanism'', to codify the risk...

  16. Particle swarm optimization with recombination and dynamic linkage discovery.

    PubMed

    Chen, Ying-Ping; Peng, Wen-Chih; Jian, Ming-Chung

    2007-12-01

    In this paper, we try to improve the performance of the particle swarm optimizer by incorporating the linkage concept, which is an essential mechanism in genetic algorithms, and design a new linkage identification technique called dynamic linkage discovery to address the linkage problem in real-parameter optimization problems. Dynamic linkage discovery is a costless and effective linkage recognition technique that adapts the linkage configuration by employing only the selection operator without extra judging criteria irrelevant to the objective function. Moreover, a recombination operator that utilizes the discovered linkage configuration to promote the cooperation of particle swarm optimizer and dynamic linkage discovery is accordingly developed. By integrating the particle swarm optimizer, dynamic linkage discovery, and recombination operator, we propose a new hybridization of optimization methodologies called particle swarm optimization with recombination and dynamic linkage discovery (PSO-RDL). In order to study the capability of PSO-RDL, numerical experiments were conducted on a set of benchmark functions as well as on an important real-world application. The benchmark functions used in this paper were proposed in the 2005 Institute of Electrical and Electronics Engineers Congress on Evolutionary Computation. The experimental results on the benchmark functions indicate that PSO-RDL can provide a level of performance comparable to that given by other advanced optimization techniques. In addition to the benchmark, PSO-RDL was also used to solve the economic dispatch (ED) problem for power systems, which is a real-world problem and highly constrained. The results indicate that PSO-RDL can successfully solve the ED problem for the three-unit power system and obtain the currently known best solution for the 40-unit system.

  17. A fortran program for Monte Carlo simulation of oil-field discovery sequences

    USGS Publications Warehouse

    Bohling, Geoffrey C.; Davis, J.C.

    1993-01-01

    We have developed a program for performing Monte Carlo simulation of oil-field discovery histories. A synthetic parent population of fields is generated as a finite sample from a distribution of specified form. The discovery sequence then is simulated by sampling without replacement from this parent population in accordance with a probabilistic discovery process model. The program computes a chi-squared deviation between synthetic and actual discovery sequences as a function of the parameters of the discovery process model, the number of fields in the parent population, and the distributional parameters of the parent population. The program employs the three-parameter log gamma model for the distribution of field sizes and employs a two-parameter discovery process model, allowing the simulation of a wide range of scenarios. ?? 1993.

  18. Pituitary adenylate cyclase-activating polypeptide: a novel peptide with protean implications.

    PubMed

    Pisegna, Joseph R; Oh, David S

    2007-02-01

    The purpose of this review is to highlight the importance of pituitary adenylate cyclase-activating polypeptide in physiological processes and to describe how this peptide is becoming increasingly recognized as having a major role in the body. Since its discovery in 1989, investigators have sought to determine the site of biological activity and the function of pituitary adenylate cyclase-activating polypeptide in maintaining homeostasis. Since its discovery, pituitary adenylate cyclase-activating polypeptide appears to play an important role in the regulation of processes within the central nervous system and gastrointestinal tract, as well in reproductive biology. Pituitary adenylate cyclase-activating polypeptide has been shown to regulate tumor cell growth and to regulate immune function through its effects on T lympocytes. These discoveries suggest the importance of pituitary adenylate cyclase-activating polypeptide in neuronal development, neuronal function, gastrointestinal tract function and reproduction. Future studies will examine more closely the role of pituitary adenylate cyclase-activating polypeptide in regulation of malignantly transformed cells, as well as in regulation of immune function.

  19. Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates.

    PubMed

    Sirvent, Juan Alberto; Lücking, Ulrich

    2017-04-06

    Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for the treatment of cancer, roniciclib (pan-CDK inhibitor), BAY 1143572 (P-TEFb inhibitor), and AZD 6738 (ATR inhibitor), have recently drawn considerable attention. Whilst the interest in this underrepresented functional group in drug discovery is clearly on the rise, there remains an incomplete understanding of the medicinal-chemistry-relevant properties of sulfoximines. Herein we report the synthesis and in vitro characterization of a variety of sulfoximine analogues of marketed drugs and advanced clinical candidates to gain a better understanding of this neglected functional group and its potential in drug discovery. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. 77 FR 65413 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Pistoia Alliance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Pistoia Alliance, Inc. Notice is hereby given that, on September 20, 2012, pursuant to Section [[Page 65414

  1. Privacy-Preserving Relationship Path Discovery in Social Networks

    NASA Astrophysics Data System (ADS)

    Mezzour, Ghita; Perrig, Adrian; Gligor, Virgil; Papadimitratos, Panos

    As social networks sites continue to proliferate and are being used for an increasing variety of purposes, the privacy risks raised by the full access of social networking sites over user data become uncomfortable. A decentralized social network would help alleviate this problem, but offering the functionalities of social networking sites is a distributed manner is a challenging problem. In this paper, we provide techniques to instantiate one of the core functionalities of social networks: discovery of paths between individuals. Our algorithm preserves the privacy of relationship information, and can operate offline during the path discovery phase. We simulate our algorithm on real social network topologies.

  2. Quantifying the Ease of Scientific Discovery

    PubMed Central

    Arbesman, Samuel

    2012-01-01

    It has long been known that scientific output proceeds on an exponential increase, or more properly, a logistic growth curve. The interplay between effort and discovery is clear, and the nature of the functional form has been thought to be due to many changes in the scientific process over time. Here I show a quantitative method for examining the ease of scientific progress, another necessary component in understanding scientific discovery. Using examples from three different scientific disciplines – mammalian species, chemical elements, and minor planets – I find the ease of discovery to conform to an exponential decay. In addition, I show how the pace of scientific discovery can be best understood as the outcome of both scientific output and ease of discovery. A quantitative study of the ease of scientific discovery in the aggregate, such as done here, has the potential to provide a great deal of insight into both the nature of future discoveries and the technical processes behind discoveries in science. PMID:22328796

  3. Quantifying the Ease of Scientific Discovery.

    PubMed

    Arbesman, Samuel

    2011-02-01

    It has long been known that scientific output proceeds on an exponential increase, or more properly, a logistic growth curve. The interplay between effort and discovery is clear, and the nature of the functional form has been thought to be due to many changes in the scientific process over time. Here I show a quantitative method for examining the ease of scientific progress, another necessary component in understanding scientific discovery. Using examples from three different scientific disciplines - mammalian species, chemical elements, and minor planets - I find the ease of discovery to conform to an exponential decay. In addition, I show how the pace of scientific discovery can be best understood as the outcome of both scientific output and ease of discovery. A quantitative study of the ease of scientific discovery in the aggregate, such as done here, has the potential to provide a great deal of insight into both the nature of future discoveries and the technical processes behind discoveries in science.

  4. Comparison: Discovery on WSMOLX and miAamics/jABC

    NASA Astrophysics Data System (ADS)

    Kubczak, Christian; Vitvar, Tomas; Winkler, Christian; Zaharia, Raluca; Zaremba, Maciej

    This chapter compares the solutions to the SWS-Challenge discovery problems provided by DERI Galway and the joint solution from the Technical University of Dortmund and University of Postdam. The two approaches are described in depth in Chapters 10 and 13. The discovery scenario raises problems associated with making service discovery an automated process. It requires fine-grained specifications of search requests and service functionality including support for fetching dynamic information during the discovery process (e.g., shipment price). Both teams utilize semantics to describe services, service requests and data models in order to enable search at the required fine-grained level of detail.

  5. 75 FR 4422 - Notice Pursuant to The National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

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  7. 7 CFR 1.411 - Definitions.

    Code of Federal Regulations, 2010 CFR

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    ... Sourcing area applicant means a person who submits a sourcing area application pursuant to these rules, or a person who sourcing area is subject to formal review pursuant to 36 CFR 223.191(e). (b) Decision... Sourcing Area Applications and Formal Review of Sourcing Areas Pursuant to the Forest Resources...

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    Code of Federal Regulations, 2011 CFR

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    Code of Federal Regulations, 2011 CFR

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  17. 17 CFR 200.30-1 - Delegation of authority to Director of Division of Corporation Finance.

    Code of Federal Regulations, 2013 CFR

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  18. 17 CFR 200.30-1 - Delegation of authority to Director of Division of Corporation Finance.

    Code of Federal Regulations, 2012 CFR

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    Code of Federal Regulations, 2011 CFR

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-67093; File No. SR-BATS-2012-018] Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend BATS Rules Related to the Operation of BATS Post Only Orders and Match Trade Prevention Functionality June 1, 2012. Pursuant to...

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-08

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-65869; File No. SR-Phlx-2011-161] Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Modify Its Optional Anti-Internalization Functionality December 2, 2011. Pursuant to Section 19(b)(1) of the Securities Exchange Act of...

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-65867; File No. SR-BX-2011-080] Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Modify Its Optional Anti-Internalization Functionality December 2, 2011. Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934...

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    Federal Register 2010, 2011, 2012, 2013, 2014

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  4. 17 CFR 210.4-10 - Financial accounting and reporting for oil and gas producing activities pursuant to the Federal...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... natural gas liquids, or natural gas (“oil and gas”) in their natural states and original locations; (B... processing gas to extract liquid hydrocarbons); and (D) Extraction of saleable hydrocarbons, in the solid... production function as: a. The first point at which oil, gas, or gas liquids, natural or synthetic, are...

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    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... natural gas liquids, or natural gas (“oil and gas”) in their natural states and original locations; (B... processing gas to extract liquid hydrocarbons); and (D) Extraction of saleable hydrocarbons, in the solid... production function as: a. The first point at which oil, gas, or gas liquids, natural or synthetic, are...

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-65779; File No. SR-Phlx-2011-152] Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Perform a Test of Routing Functionality November 17, 2011. Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934 (``Act''),\\...

  7. Computational methods for a three-dimensional model of the petroleum-discovery process

    USGS Publications Warehouse

    Schuenemeyer, J.H.; Bawiec, W.J.; Drew, L.J.

    1980-01-01

    A discovery-process model devised by Drew, Schuenemeyer, and Root can be used to predict the amount of petroleum to be discovered in a basin from some future level of exploratory effort: the predictions are based on historical drilling and discovery data. Because marginal costs of discovery and production are a function of field size, the model can be used to make estimates of future discoveries within deposit size classes. The modeling approach is a geometric one in which the area searched is a function of the size and shape of the targets being sought. A high correlation is assumed between the surface-projection area of the fields and the volume of petroleum. To predict how much oil remains to be found, the area searched must be computed, and the basin size and discovery efficiency must be estimated. The basin is assumed to be explored randomly rather than by pattern drilling. The model may be used to compute independent estimates of future oil at different depth intervals for a play involving multiple producing horizons. We have written FORTRAN computer programs that are used with Drew, Schuenemeyer, and Root's model to merge the discovery and drilling information and perform the necessary computations to estimate undiscovered petroleum. These program may be modified easily for the estimation of remaining quantities of commodities other than petroleum. ?? 1980.

  8. 75 FR 1492 - Commission Guidance Regarding Independent Public Accountant Engagements Performed Pursuant to...

    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Code of Federal Regulations, 2010 CFR

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    Code of Federal Regulations, 2010 CFR

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    Code of Federal Regulations, 2010 CFR

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  1. Application of chemical biology in target identification and drug discovery.

    PubMed

    Zhu, Yue; Xiao, Ting; Lei, Saifei; Zhou, Fulai; Wang, Ming-Wei

    2015-09-01

    Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological problems through searching previously unknown targets for pharmacologically active small molecules or finding ligands for well-defined drug targets. It is a powerful tool to study how these small molecules interact with their respective targets, as well as their roles in signal transduction, molecular recognition and cell functions. There have been an increasing number of new therapeutic targets being identified and subsequently validated as a result of advances in functional genomics, which in turn led to the discovery of numerous active small molecules via a variety of high-throughput screening initiatives. In this review, we highlight some applications of chemical biology in the context of drug discovery.

  2. Discovery of novel drug targets and their functions using phenotypic screening of natural products.

    PubMed

    Chang, Junghwa; Kwon, Ho Jeong

    2016-03-01

    Natural products are valuable resources that provide a variety of bioactive compounds and natural pharmacophores in modern drug discovery. Discovery of biologically active natural products and unraveling their target proteins to understand their mode of action have always been critical hurdles for their development into clinical drugs. For effective discovery and development of bioactive natural products into novel therapeutic drugs, comprehensive screening and identification of target proteins are indispensable. In this review, a systematic approach to understanding the mode of action of natural products isolated using phenotypic screening involving chemical proteomics-based target identification is introduced. This review highlights three natural products recently discovered via phenotypic screening, namely glucopiericidin A, ecumicin, and terpestacin, as representative case studies to revisit the pivotal role of natural products as powerful tools in discovering the novel functions and druggability of targets in biological systems and pathological diseases of interest.

  3. Efficient discovery of bioactive scaffolds by activity-directed synthesis

    NASA Astrophysics Data System (ADS)

    Karageorgis, George; Warriner, Stuart; Nelson, Adam

    2014-10-01

    The structures and biological activities of natural products have often provided inspiration in drug discovery. The functional benefits of natural products to the host organism steers the evolution of their biosynthetic pathways. Here, we describe a discovery approach—which we term activity-directed synthesis—in which reactions with alternative outcomes are steered towards functional products. Arrays of catalysed reactions of α-diazo amides, whose outcome was critically dependent on the specific conditions used, were performed. The products were assayed at increasingly low concentration, with the results informing the design of a subsequent reaction array. Finally, promising reactions were scaled up and, after purification, submicromolar ligands based on two scaffolds with no previous annotated activity against the androgen receptor were discovered. The approach enables the discovery, in tandem, of both bioactive small molecules and associated synthetic routes, analogous to the evolution of biosynthetic pathways to yield natural products.

  4. Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence-Function Space and Genome Context to Discover Novel Functions.

    PubMed

    Gerlt, John A

    2017-08-22

    The exponentially increasing number of protein and nucleic acid sequences provides opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural products, thereby adding to our knowledge of biochemistry and biology. The challenge has evolved from generating sequence information to mining the databases to integrating and leveraging the available information, i.e., the availability of "genomic enzymology" web tools. Web tools that allow identification of biosynthetic gene clusters are widely used by the natural products/synthetic biology community, thereby facilitating the discovery of novel natural products and the enzymes responsible for their biosynthesis. However, many novel enzymes with interesting mechanisms participate in uncharacterized small-molecule metabolic pathways; their discovery and functional characterization also can be accomplished by leveraging information in protein and nucleic acid databases. This Perspective focuses on two genomic enzymology web tools that assist the discovery novel metabolic pathways: (1) Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST) for generating sequence similarity networks to visualize and analyze sequence-function space in protein families and (2) Enzyme Function Initiative-Genome Neighborhood Tool (EFI-GNT) for generating genome neighborhood networks to visualize and analyze the genome context in microbial and fungal genomes. Both tools have been adapted to other applications to facilitate target selection for enzyme discovery and functional characterization. As the natural products community has demonstrated, the enzymology community needs to embrace the essential role of web tools that allow the protein and genome sequence databases to be leveraged for novel insights into enzymological problems.

  5. Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence–Function Space and Genome Context to Discover Novel Functions

    PubMed Central

    2017-01-01

    The exponentially increasing number of protein and nucleic acid sequences provides opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural products, thereby adding to our knowledge of biochemistry and biology. The challenge has evolved from generating sequence information to mining the databases to integrating and leveraging the available information, i.e., the availability of “genomic enzymology” web tools. Web tools that allow identification of biosynthetic gene clusters are widely used by the natural products/synthetic biology community, thereby facilitating the discovery of novel natural products and the enzymes responsible for their biosynthesis. However, many novel enzymes with interesting mechanisms participate in uncharacterized small-molecule metabolic pathways; their discovery and functional characterization also can be accomplished by leveraging information in protein and nucleic acid databases. This Perspective focuses on two genomic enzymology web tools that assist the discovery novel metabolic pathways: (1) Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST) for generating sequence similarity networks to visualize and analyze sequence–function space in protein families and (2) Enzyme Function Initiative-Genome Neighborhood Tool (EFI-GNT) for generating genome neighborhood networks to visualize and analyze the genome context in microbial and fungal genomes. Both tools have been adapted to other applications to facilitate target selection for enzyme discovery and functional characterization. As the natural products community has demonstrated, the enzymology community needs to embrace the essential role of web tools that allow the protein and genome sequence databases to be leveraged for novel insights into enzymological problems. PMID:28826221

  6. CRISPR/Cas9: From Genome Engineering to Cancer Drug Discovery

    PubMed Central

    Luo, Ji

    2016-01-01

    Advances in translational research are often driven by new technologies. The advent of microarrays, next-generation sequencing, proteomics and RNA interference (RNAi) have led to breakthroughs in our understanding of the mechanisms of cancer and the discovery of new cancer drug targets. The discovery of the bacterial clustered regularly interspaced palindromic repeat (CRISPR) system and its subsequent adaptation as a tool for mammalian genome engineering has opened up new avenues for functional genomics studies. This review will focus on the utility of CRISPR in the context of cancer drug target discovery. PMID:28603775

  7. Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery?

    PubMed Central

    Borsook, David; Hargreaves, Richard; Becerra, Lino

    2011-01-01

    Introduction The bar for developing new treatments for CNS disease is getting progressively higher and fewer novel mechanisms are being discovered, validated and developed. The high costs of drug discovery necessitate early decisions to ensure the best molecules and hypotheses are tested in expensive late stage clinical trials. The discovery of brain imaging biomarkers that can bridge preclinical to clinical CNS drug discovery and provide a ‘language of translation’ affords the opportunity to improve the objectivity of decision-making. Areas Covered This review discusses the benefits, challenges and potential issues of using a science based biomarker strategy to change the paradigm of CNS drug development and increase success rates in the discovery of new medicines. The authors have summarized PubMed and Google Scholar based publication searches to identify recent advances in functional, structural and chemical brain imaging and have discussed how these techniques may be useful in defining CNS disease state and drug effects during drug development. Expert opinion The use of novel brain imaging biomarkers holds the bold promise of making neuroscience drug discovery smarter by increasing the objectivity of decision making thereby improving the probability of success of identifying useful drugs to treat CNS diseases. Functional imaging holds the promise to: (1) define pharmacodynamic markers as an index of target engagement (2) improve translational medicine paradigms to predict efficacy; (3) evaluate CNS efficacy and safety based on brain activation; (4) determine brain activity drug dose-response relationships and (5) provide an objective evaluation of symptom response and disease modification. PMID:21765857

  8. Metagenomics and novel gene discovery

    PubMed Central

    Culligan, Eamonn P; Sleator, Roy D; Marchesi, Julian R; Hill, Colin

    2014-01-01

    Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Herein, we review both sequence-based and functional metagenomic methods to uncover novel genes and outline some of the associated problems of each type of approach, as well as potential solutions. Furthermore, we discuss the potential for metagenomic biotherapeutic discovery, with a particular focus on the human gut microbiome and finally, we outline how the discovery of novel genes may be used to create bioengineered probiotics. PMID:24317337

  9. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

    PubMed Central

    Stark, Alexander; Lin, Michael F.; Kheradpour, Pouya; Pedersen, Jakob S.; Parts, Leopold; Carlson, Joseph W.; Crosby, Madeline A.; Rasmussen, Matthew D.; Roy, Sushmita; Deoras, Ameya N.; Ruby, J. Graham; Brennecke, Julius; Hodges, Emily; Hinrichs, Angie S.; Caspi, Anat; Paten, Benedict; Park, Seung-Won; Han, Mira V.; Maeder, Morgan L.; Polansky, Benjamin J.; Robson, Bryanne E.; Aerts, Stein; van Helden, Jacques; Hassan, Bassem; Gilbert, Donald G.; Eastman, Deborah A.; Rice, Michael; Weir, Michael; Hahn, Matthew W.; Park, Yongkyu; Dewey, Colin N.; Pachter, Lior; Kent, W. James; Haussler, David; Lai, Eric C.; Bartel, David P.; Hannon, Gregory J.; Kaufman, Thomas C.; Eisen, Michael B.; Clark, Andrew G.; Smith, Douglas; Celniker, Susan E.; Gelbart, William M.; Kellis, Manolis

    2008-01-01

    Sequencing of multiple related species followed by comparative genomics analysis constitutes a powerful approach for the systematic understanding of any genome. Here, we use the genomes of 12 Drosophila species for the de novo discovery of functional elements in the fly. Each type of functional element shows characteristic patterns of change, or ‘evolutionary signatures’, dictated by its precise selective constraints. Such signatures enable recognition of new protein-coding genes and exons, spurious and incorrect gene annotations, and numerous unusual gene structures, including abundant stop-codon readthrough. Similarly, we predict non-protein-coding RNA genes and structures, and new microRNA (miRNA) genes. We provide evidence of miRNA processing and functionality from both hairpin arms and both DNA strands. We identify several classes of pre- and post-transcriptional regulatory motifs, and predict individual motif instances with high confidence. We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies. PMID:17994088

  10. 46 CFR 147.8 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 147.8 Section 147.8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.8 OMB control numbers assigned pursuant...

  11. 46 CFR 147.8 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 147.8 Section 147.8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.8 OMB control numbers assigned pursuant...

  12. 46 CFR 150.105 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 150.105 Section 150.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.105 OMB control numbers assigned pursuant to...

  13. 46 CFR 150.105 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 150.105 Section 150.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.105 OMB control numbers assigned pursuant to...

  14. 46 CFR 147.8 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 147.8 Section 147.8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.8 OMB control numbers assigned pursuant...

  15. 46 CFR 150.105 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 150.105 Section 150.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.105 OMB control numbers assigned pursuant to...

  16. 46 CFR 147.8 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 147.8 Section 147.8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.8 OMB control numbers assigned pursuant...

  17. 46 CFR 150.105 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 150.105 Section 150.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.105 OMB control numbers assigned pursuant to...

  18. 46 CFR 150.105 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 150.105 Section 150.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.105 OMB control numbers assigned pursuant to...

  19. 46 CFR 147.8 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 147.8 Section 147.8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.8 OMB control numbers assigned pursuant...

  20. 29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

  1. 29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

  2. 29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

  3. 29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

  4. 29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

  5. 46 CFR 565.13 - OMB control number assigned pursuant to the Paperwork Reduction Act

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false OMB control number assigned pursuant to the Paperwork Reduction Act 565.13 Section 565.13 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AND ACTIONS TO ADDRESS RESTRICTIVE FOREIGN MARITIME PRACTICES CONTROLLED CARRIERS § 565.13 OMB control number assigned pursuant to...

  6. 10 CFR 780.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... patent affected with the public interest pursuant to section 153a of the Atomic Energy Act of 1954 (Pub... section 157 of the Atomic Energy Act of 1954; (c) Proceedings for the grant of an award pursuant to section 157 of the Atomic Energy Act of 1954; (d) Proceedings to obtain compensation pursuant to section...

  7. 26 CFR 301.6311-2 - Payment by credit card and debit card.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... business and is not returned pursuant to paragraph (d)(3) of this section. (c) Payment not made—(1... required to be returned pursuant to paragraph (d)(3) of this section. This continuing liability of the.... (3) Return of funds pursuant to error resolution procedures. Notwithstanding section 6402, if a...

  8. 78 FR 7456 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., Center for Educational Testing and Evaluation, University of Kansas, Lawrence, KS; Indian River School... Department of Justice published a notice in the Federal Register pursuant to Section 6(b) of the Act on...

  9. 77 FR 40085 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-American Gap...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--American Gap Association Notice is hereby given that, on June 6, 2012, pursuant to...'' educational programs. Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR Doc. 2012...

  10. 31 CFR 598.802 - Availability of information pursuant to the Freedom of Information Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Availability of information pursuant to the Freedom of Information Act. 598.802 Section 598.802 Money and Finance: Treasury Regulations... FOREIGN NARCOTICS KINGPIN SANCTIONS REGULATIONS Procedures § 598.802 Availability of information pursuant...

  11. 31 CFR 598.802 - Availability of information pursuant to the Freedom of Information Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Availability of information pursuant to the Freedom of Information Act. 598.802 Section 598.802 Money and Finance: Treasury Regulations... FOREIGN NARCOTICS KINGPIN SANCTIONS REGULATIONS Procedures § 598.802 Availability of information pursuant...

  12. 31 CFR 598.802 - Availability of information pursuant to the Freedom of Information Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Availability of information pursuant to the Freedom of Information Act. 598.802 Section 598.802 Money and Finance: Treasury Regulations... FOREIGN NARCOTICS KINGPIN SANCTIONS REGULATIONS Procedures § 598.802 Availability of information pursuant...

  13. 31 CFR 598.802 - Availability of information pursuant to the Freedom of Information Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Availability of information pursuant to the Freedom of Information Act. 598.802 Section 598.802 Money and Finance: Treasury Regulations... FOREIGN NARCOTICS KINGPIN SANCTIONS REGULATIONS Procedures § 598.802 Availability of information pursuant...

  14. 76 FR 13377 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election...

  15. 75 FR 16764 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election...

  16. 75 FR 6643 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election...

  17. 75 FR 27743 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election Assistance...

  18. 75 FR 39671 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election...

  19. 75 FR 41454 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election...

  20. 75 FR 75969 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, the U.S. Election...

  1. 76 FR 66324 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cooperative Research Group on Nasgro Development and Support Notice is hereby given that, on October 3, 2011, pursuant to Section 6(a) of the National Cooperative Research and Production...

  2. 23 CFR 710.709 - Determination of fair market value.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... State and local law. (d) If a concession agreement is not awarded pursuant to a competitive process, the... pursuant to a competitive process with more than one bidder shall be deemed to be fair market value. Any concession agreement awarded pursuant to a competitive process with only one bidder shall be presumed to be...

  3. 23 CFR 710.709 - Determination of fair market value.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... State and local law. (d) If a concession agreement is not awarded pursuant to a competitive process, the... pursuant to a competitive process with more than one bidder shall be deemed to be fair market value. Any concession agreement awarded pursuant to a competitive process with only one bidder shall be presumed to be...

  4. 75 FR 518 - Designation of One Entity Pursuant to Executive Order 13438

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of One Entity Pursuant to... designated entity whose property and interests in property are blocked pursuant to Executive Order 13438 of....'' DATES: The designation by the Secretary of the Treasury of the entity and individual identified in this...

  5. 75 FR 14257 - Designation of Two Entities Pursuant to Executive Order 13224

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Two Entities Pursuant... two entities identified in this notice, pursuant to Executive Order 13224, is effective on March 18... Order, as amended by Executive Order 13268 of July 2, 2002, 13 individuals and 16 entities as subject to...

  6. 15 CFR 744.12 - Restrictions on exports and reexports to persons designated in or pursuant to Executive Order...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist... persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist) (SDGT... part 594, the Global Terrorism Sanctions Regulations. OFAC announces the names of persons designated...

  7. 15 CFR 744.12 - Restrictions on exports and reexports to persons designated in or pursuant to Executive Order...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist... persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist) (SDGT... part 594, the Global Terrorism Sanctions Regulations. OFAC announces the names of persons designated...

  8. 15 CFR 744.12 - Restrictions on exports and reexports to persons designated in or pursuant to Executive Order...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... to persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist... persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist) (SDGT... part 594, the Global Terrorism Sanctions Regulations. OFAC announces the names of persons designated...

  9. 15 CFR 744.12 - Restrictions on exports and reexports to persons designated in or pursuant to Executive Order...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist... persons designated in or pursuant to Executive Order 13224 (Specially Designated Global Terrorist) (SDGT... part 594, the Global Terrorism Sanctions Regulations. OFAC announces the names of persons designated...

  10. 76 FR 79219 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Sematech, Inc. d...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ...., Hsinchu, TAIWAN; Global Foundaries Inc., Milpitas, CA; Freescale Semiconductor, Inc., Austin, TX; Infineon... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... 18, 2011, pursuant to section 6(a) of the National Cooperative Research and Production Act of 1993...

  11. 75 FR 24972 - Notice Pursuant to the National Cooperative Research and Production Act of 1993 ODVA, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ..., Greifensee, SWITZERLAND; Ten X Technology, Inc., Austin, TX; Cervis Inc., Warrendale, PA; IDEC IZUNI... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... that, on March 17, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production...

  12. 78 FR 37572 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-U.S. Photovoltaic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... circumstances. Specifically, Esgee Technologies, Inc., Austin, TX; and Magnolia Solar, Albany, NY, have been... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... 21, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993...

  13. 77 FR 34067 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ..., 21 CT, Inc., Austin, TX; Cerebrus Corporation, Morris Plains, NJ; Conax Florida Corporation, St... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., 2012, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S...

  14. 78 FR 14837 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Health Product...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... (individual member), Austin, TX; Ted van der Linden (individual member), Falls Church, VA; Scott Day... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... February 12, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993...

  15. 78 FR 37572 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Sematech, Inc. D...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ..., Windsor, Berkshire, UNITED KINGDOM; Freescale Semiconductor, Inc., Austin, TX; and TriQuint Semiconductors... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S...

  16. 76 FR 72724 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    .... Specifically, Accurate Munition Systems, Inc., Austin, TX; Excelitas Technologies Sensors, Inc., Miamisburg, OH... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... 04, 2011, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993...

  17. 78 FR 16868 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ..., PA; Systems and Materials Research Corporation, Austin, TX; and Targeted GeoSystems, LLC, Madison, AL... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... 19, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993...

  18. 76 FR 16820 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... 25, 2011, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993.... Specifically, Directed Energy Technologies, Inc., Sumerduck, VA; MaxPower, Inc., Harleysville, PA; Omnitek...

  19. 76 FR 77251 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Consortium for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ...., Bedford, IN; UXB International, Blacksburg, VA; Virginia Tech Applied Research Corporation, Blacksburg, VA... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... hereby given that, on November 18, 2011, pursuant to Section 6(a) of the National Cooperative Research...

  20. 75 FR 35089 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ..., Tucson, AZ; ANEASOL, LLC, Santa Fe, NM; AMEC, Somerset, NJ; Applied Research Associates, Albuquerque, NM... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., 2010, pursuant to section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S...

  1. 78 FR 45285 - Certifications Pursuant to Section 609 of Public Law 101-162

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... DEPARTMENT OF STATE [Public Notice 8391] Certifications Pursuant to Section 609 of Public Law 101-162 SUMMARY: On May 2, 2013, the Department of State certified, pursuant to Section 609 of Public Law...: (202) 647-5827; email: [email protected] . SUPPLEMENTARY INFORMATION: Section 609 of Public Law 101...

  2. 75 FR 8116 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Ice Crystal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Ice Crystal Consortium Notice is hereby given that, on December 31, 2009, pursuant to.... (``the Act''), the Ice Crystal Consortium (``ICC'') has filed written notifications simultaneously with...

  3. 40 CFR 148.23 - Review of exemptions granted pursuant to a petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Procedures § 148.23 Review of exemptions granted pursuant to a petition. (a) When considering whether to... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Review of exemptions granted pursuant to a petition. 148.23 Section 148.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  4. 17 CFR 201.431 - Commission consideration of actions made pursuant to delegated authority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Commission Review § 201.431 Commission consideration of actions made pursuant to delegated authority. (a) Scope of review. The Commission may affirm, reverse, modify, set aside or remand for further proceedings... of this chapter. (b) Standards for granting review pursuant to a petition for review—(1) Mandatory...

  5. 37 CFR 1.137 - Revival of abandoned application, terminated or limited reexamination prosecution, or lapsed patent.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... petition may be filed pursuant to this paragraph to revive an abandoned application, a reexamination... unintentional, a petition may be filed pursuant to this paragraph to revive an abandoned application, a... fee. (d) Terminal disclaimer. (1) Any petition to revive pursuant to this section in a design...

  6. 76 FR 70759 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cooperative Research Group on Energy Storage System Evaluation and Safety Notice is hereby given that, on October 6, 2011, pursuant to Section 6(a) of the National Cooperative Research and...

  7. 76 FR 27374 - Determination Pursuant to Section 451 of the Foreign Assistance Act Relating to Assistance for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... DEPARTMENT OF STATE [Public Notice: 7452] Determination Pursuant to Section 451 of the Foreign Assistance Act Relating to Assistance for Individuals To Support Near East Regional Democracy Pursuant to... individuals in support of Near East Regional Democracy. This Determination shall be reported to the Congress...

  8. 18 CFR 389.101 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... assigned pursuant to the Paperwork Reduction Act. 389.101 Section 389.101 Conservation of Power and Water... FOR COMMISSION INFORMATION COLLECTION REQUIREMENTS § 389.101 OMB control numbers assigned pursuant to... citations affecting § 389.101, see the List of CFR Sections Affected, which appears in the Finding Aids...

  9. 18 CFR 389.101 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... assigned pursuant to the Paperwork Reduction Act. 389.101 Section 389.101 Conservation of Power and Water... FOR COMMISSION INFORMATION COLLECTION REQUIREMENTS § 389.101 OMB control numbers assigned pursuant to... citations affecting § 389.101, see the List of CFR Sections Affected, which appears in the Finding Aids...

  10. 76 FR 61472 - Determination Pursuant to Section 2121(h) of the Full-Year Continuing Appropriations Act, 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... DEPARTMENT OF STATE [Public Notice: 7633] Determination Pursuant to Section 2121(h) of the Full-Year Continuing Appropriations Act, 2011, Relating to Foreign Military Financing for Lebanon Pursuant... the CR for assistance for Lebanon is in the national security interest of the United States. This...

  11. 29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act... an action level as a limitation on requirements for periodic monitoring (para. (e)(3)), medical...

  12. 46 CFR 110.01-2 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 110.01-2 Section 110.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-2 OMB control numbers assigned pursuant to...

  13. 46 CFR 110.01-2 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 110.01-2 Section 110.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-2 OMB control numbers assigned pursuant to...

  14. 46 CFR 110.01-2 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 110.01-2 Section 110.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-2 OMB control numbers assigned pursuant to...

  15. 3 CFR - Limited Waiver of Certain Sanctions Imposed by, and Delegation of Certain Authorities Pursuant to...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Delegation of Certain Authorities Pursuant to, the Tom Lantos Block Burmese JADE (Junta's Anti-Democratic... Authorities Pursuant to, the Tom Lantos Block Burmese JADE (Junta's Anti-Democratic Efforts) Act of 2008... (Junta's Anti-Democratic Efforts) Act of 2008 (Public Law 110-286) (JADE Act) and section 301 of title 3...

  16. 75 FR 10228 - Publication of State Plan Pursuant to the Help America Vote Act; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act; Correction AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice; correction. SUMMARY: The U.S... caption to read: SUMMARY: Pursuant to sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA...

  17. 77 FR 23237 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, as amended by Section 622...

  18. 75 FR 51759 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Pub. L. 107-252, the U.S. Election Assistance...

  19. 77 FR 75425 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, as amended by Section 622...

  20. 78 FR 56939 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ..., Dell Inc., Austin, TX; Miami-Dade College--Virtual College, Miami, FL; National Labor College, Silver... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...

  1. 78 FR 22296 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Heterogeneous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S... Communications AB, Lund, SWEDEN, and Fabric Engine, Cowansville, Quebec, CANADA, have been added as parties to...

  2. 29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act. Occupational Exposure to ________ Permanent Standard (insert section number of standard) (a) Scope and...

  3. 29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act. Occupational Exposure to ________ Permanent Standard (insert section number of standard) (a) Scope and...

  4. 29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act. Occupational Exposure to ________ Permanent Standard (insert section number of standard) (a) Scope and...

  5. 10 CFR 707.14 - Action pursuant to a determination of illegal drug use.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Action pursuant to a determination of illegal drug use. 707.14 Section 707.14 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES Procedures § 707.14 Action pursuant to a determination of illegal drug use. (a) When an applicant for...

  6. 10 CFR 707.14 - Action pursuant to a determination of illegal drug use.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Action pursuant to a determination of illegal drug use. 707.14 Section 707.14 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES Procedures § 707.14 Action pursuant to a determination of illegal drug use. (a) When an applicant for...

  7. 10 CFR 707.14 - Action pursuant to a determination of illegal drug use.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Action pursuant to a determination of illegal drug use. 707.14 Section 707.14 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES Procedures § 707.14 Action pursuant to a determination of illegal drug use. (a) When an applicant for...

  8. 10 CFR 707.14 - Action pursuant to a determination of illegal drug use.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Action pursuant to a determination of illegal drug use. 707.14 Section 707.14 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES Procedures § 707.14 Action pursuant to a determination of illegal drug use. (a) When an applicant for...

  9. 10 CFR 707.14 - Action pursuant to a determination of illegal drug use.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Action pursuant to a determination of illegal drug use. 707.14 Section 707.14 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES Procedures § 707.14 Action pursuant to a determination of illegal drug use. (a) When an applicant for...

  10. 76 FR 69732 - Pesticide Products; Receipt of Applications To Register New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... registered active ingredients, pursuant to the provisions of section 3(c) of the Federal Insecticide..., pursuant to section 3(c)(4) of FIFRA. DATES: Comments must be received on or before December 9, 2011... 3(c) of FIFRA, and is publishing this Notice of such applications pursuant to section 3(c)(4) of...

  11. 46 CFR 110.01-2 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 110.01-2 Section 110.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-2 OMB control numbers assigned pursuant to...

  12. 46 CFR 110.01-2 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false OMB control numbers assigned pursuant to the Paperwork Reduction Act. 110.01-2 Section 110.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-2 OMB control numbers assigned pursuant to...

  13. 76 FR 79217 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Center...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--National Center for Manufacturing Sciences, Inc. Notice is hereby given that, on November 22, 2011, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993...

  14. 17 CFR 201.430 - Appeal of actions made pursuant to delegated authority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXCHANGE COMMISSION RULES OF PRACTICE Rules of Practice Appeal to the Commission and Commission Review... 200.30-18 of this chapter may seek review of the action pursuant to paragraph (b) of this section. (b) Procedure—(1) Notice of intention to petition for review. A party to an action made pursuant to delegated...

  15. 5 CFR 297.402 - Disclosure pursuant to a compulsory legal process served on the Office.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Disclosure pursuant to a compulsory legal process served on the Office. 297.402 Section 297.402 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PRIVACY PROCEDURES FOR PERSONNEL RECORDS Disclosure of Records § 297.402 Disclosure pursuant to a compulsory...

  16. 78 FR 77110 - Publication of State Plan Pursuant to the Help America Vote Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act AGENCY: U.S. Election Assistance Commission (EAC). ACTION: Notice. SUMMARY: Pursuant to Sections 254(a)(11)(A) and 255(b) of the Help America Vote Act (HAVA), Public Law 107-252, as amended by Section 622...

  17. 42 CFR 124.505 - Eligibility criteria.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... current poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the individual or... than twice the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the... but not greater than three times the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902...

  18. 42 CFR 124.505 - Eligibility criteria.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... current poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the individual or... than twice the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the... but not greater than three times the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902...

  19. 42 CFR 124.505 - Eligibility criteria.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... current poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the individual or... than twice the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the... but not greater than three times the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902...

  20. 42 CFR 124.505 - Eligibility criteria.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... current poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the individual or... than twice the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the... but not greater than three times the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902...

  1. 75 FR 30440 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Recreational Off...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Recreational Off-Highway Vehicle Association (Formerly Known as Recreational Off-Highway Vehicle Organization) Notice is hereby given that, on May 4, 2010, pursuant to Section 6(a) of the National Cooperative Research and...

  2. 77 FR 20693 - Designation of Three Individuals Pursuant to Executive Order 13573 of May 18, 2011, “Blocking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... Pursuant to Executive Order 13573 of May 18, 2011, ``Blocking Property of Senior Officials of the... whose property and interests in property are blocked pursuant to Executive Order 13573 of May 18, 2011...-622-0077. Background On May 18, 2011, the President issued Executive Order 13573, ``Blocking Property...

  3. 42 CFR 124.505 - Eligibility criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... current poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the individual or... than twice the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902 that applies to the... but not greater than three times the poverty line issued by the Secretary pursuant to 42 U.S.C. 9902...

  4. 77 FR 61458 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... Offer Members the Ability To Pay a Regulatory Fine Pursuant to an Installment Plan October 2, 2012... pay a regulatory fine pursuant to an installment plan, under certain conditions. The text of the... Action for Failure to Pay'' to offer members the ability to pay a regulatory fine pursuant to an...

  5. 26 CFR 1.346-1 - Partial liquidation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... pursuant to section 346(b) if it consists of the proceeds of the sale of the assets of a trade or business... redemption of all of the stock of the corporation pursuant to a plan of complete liquidation, or (2) The... the corporation pursuant to a plan, and (iii) Occurs within the taxable year in which the plan is...

  6. 15 CFR 744.22 - Restrictions on exports, reexports and transfers to persons whose property and interests in...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310..., reexports, and transfers to persons whose property and interests in property are blocked pursuant to...

  7. 15 CFR 744.22 - Restrictions on exports, reexports and transfers to persons whose property and interests in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310..., reexports, and transfers to persons whose property and interests in property are blocked pursuant to...

  8. 15 CFR 744.22 - Restrictions on exports, reexports and transfers to persons whose property and interests in...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310..., reexports, and transfers to persons whose property and interests in property are blocked pursuant to...

  9. 15 CFR 744.22 - Restrictions on exports, reexports and transfers to persons whose property and interests in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310..., reexports, and transfers to persons whose property and interests in property are blocked pursuant to...

  10. 15 CFR 744.22 - Restrictions on exports, reexports and transfers to persons whose property and interests in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310... transfers to persons whose property and interests in property are blocked pursuant to Executive Orders 13310..., reexports, and transfers to persons whose property and interests in property are blocked pursuant to...

  11. 76 FR 60519 - Privacy Act of 1974; as Amended; Notice To Amend an Existing System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... functions promulgated in 5 U.S.C. 1205-06. (18) To a grand jury agent pursuant to a federal or state grand jury subpoena or in response to a prosecution request that such record or information is released for the purpose of its introduction to a grand jury. (19) To the Office of Personnel Management (OPM...

  12. 17 CFR 200.30-3 - Delegation of authority to Director of Division of Trading and Markets.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Director of Division of Trading and Markets. 200.30-3 Section 200.30-3 Commodity and Securities Exchanges... Division of Trading and Markets. Pursuant to the provisions of Pub. L. 87-592, 76 Stat. 394, 15 U.S.C. 78d... otherwise, the following functions to the Director of the Division of Trading and Markets to be performed by...

  13. 76 FR 72486 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-65780; File No. SR-BX-2011-076] Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Perform a Test of Routing Functionality November 17, 2011. Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934 (``Act''),\\1\\...

  14. Drug discovery strategies to outer membrane targets in Gram-negative pathogens.

    PubMed

    Brown, Dean G

    2016-12-15

    This review will cover selected recent examples of drug discovery strategies which target the outer membrane (OM) of Gram-negative bacteria either by disruption of outer membrane function or by inhibition of essential gene products necessary for outer membrane assembly. Significant advances in pathway elucidation, structural biology and molecular inhibitor designs have created new opportunities for drug discovery within this target-class space. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Arrayed antibody library technology for therapeutic biologic discovery.

    PubMed

    Bentley, Cornelia A; Bazirgan, Omar A; Graziano, James J; Holmes, Evan M; Smider, Vaughn V

    2013-03-15

    Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead. While this approach has led to many successful therapeutic antibodies, targets have been limited to proteins which are easily purified. In addition, selection driven discovery has produced a narrow range of antibody functionalities focused on high affinity antagonism. We review the current progress in developing arrayed protein libraries for screening-based, rather than selection-based, discovery. These single molecule per microtiter well libraries have been screened in multiplex formats against both purified antigens and directly against targets expressed on the cell surface. This facilitates the discovery of antibodies against therapeutically interesting targets (GPCRs, ion channels, and other multispanning membrane proteins) and epitopes that have been considered poorly accessible to conventional discovery methods. Copyright © 2013. Published by Elsevier Inc.

  16. Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Katz, Francine S.; Pecic, Stevan; Tran, Timothy H.

    Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reactivate inhibited AChE with improved in vivo efficacy. Here we describe our discovery of new functional groups—Mannich phenols and general bases—that are capable of reactivating OPC-inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. These discoveries, supported by preliminary in vivo results and crystallographic data,more » significantly broaden the available approaches for reactivation of AChE.« less

  17. 24 CFR 1000.548 - Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.548 Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA activities be... audit pursuant to the Single Audit Act relating to NAHASDA activities be submitted to HUD? 1000.548...

  18. 24 CFR 1000.548 - Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.548 Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA activities be... audit pursuant to the Single Audit Act relating to NAHASDA activities be submitted to HUD? 1000.548...

  19. 24 CFR 1000.548 - Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.548 Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA activities be... audit pursuant to the Single Audit Act relating to NAHASDA activities be submitted to HUD? 1000.548...

  20. 24 CFR 1000.548 - Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.548 Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA activities be... audit pursuant to the Single Audit Act relating to NAHASDA activities be submitted to HUD? 1000.548...

  1. 24 CFR 1000.548 - Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.548 Must a copy of the recipient's audit pursuant to the Single Audit Act relating to NAHASDA activities be... audit pursuant to the Single Audit Act relating to NAHASDA activities be submitted to HUD? 1000.548...

  2. 77 FR 71830 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-SGIP 2.0, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--SGIP 2.0, Inc. Notice is hereby given that, on October 17, 2012, pursuant to Section..., educational, literary, and scientific purposes, within the meaning of Section 501(c)(3) of the Internal...

  3. 45 CFR 156.50 - Financial support.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... contraceptive services on behalf of a third party administrator pursuant to 26 CFR 54.9815-2713A(b)(2)(ii) or 29... payments for contraceptive services pursuant to 26 CFR 54.9815-2713A(b)(2)(i) or (ii) or 29 CFR 2590.715... which the contraceptive services for which payments were made pursuant to 26 CFR 54.9815-2713A(b)(2) or...

  4. 45 CFR 156.50 - Financial support.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contraceptive services on behalf of a third party administrator pursuant to 26 CFR 54.9815-2713A(b)(2)(ii) or 29... payments for contraceptive services pursuant to 26 CFR 54.9815-2713A(b)(2)(i) or (ii) or 29 CFR 2590.715... which the contraceptive services for which payments were made pursuant to 26 CFR 54.9815-2713A(b)(2) or...

  5. 76 FR 3126 - Final Determination of the Assistant Administrator for Water Pursuant to Section 404(c) of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... area will have an unacceptable adverse effect on municipal water supplies, shellfish beds and fishery... Assistant Administrator for Water Pursuant to Section 404(c) of the Clean Water Act Concerning the Spruce No...: This is a notice of EPA's Final Determination pursuant to section 404(c) of the Clean Water Act to...

  6. 11 CFR 9004.4 - Use of payments; examples of qualified campaign expenses and non-qualified campaign expenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to the beginning of the expenditure report period; (4) To defray winding down costs pursuant to 11 CFR 9004.11; (5) To defray costs associated with the candidate's general election campaign paid after... payable pursuant to paragraph (a)(5) of this section and winding down costs pursuant to 11 CFR 9004.11...

  7. 11 CFR 9004.4 - Use of payments; examples of qualified campaign expenses and non-qualified campaign expenses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to the beginning of the expenditure report period; (4) To defray winding down costs pursuant to 11 CFR 9004.11; (5) To defray costs associated with the candidate's general election campaign paid after... payable pursuant to paragraph (a)(5) of this section and winding down costs pursuant to 11 CFR 9004.11...

  8. 11 CFR 9004.4 - Use of payments; examples of qualified campaign expenses and non-qualified campaign expenses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... to the beginning of the expenditure report period; (4) To defray winding down costs pursuant to 11 CFR 9004.11; (5) To defray costs associated with the candidate's general election campaign paid after... payable pursuant to paragraph (a)(5) of this section and winding down costs pursuant to 11 CFR 9004.11...

  9. 11 CFR 9004.4 - Use of payments; examples of qualified campaign expenses and non-qualified campaign expenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to the beginning of the expenditure report period; (4) To defray winding down costs pursuant to 11 CFR 9004.11; (5) To defray costs associated with the candidate's general election campaign paid after... payable pursuant to paragraph (a)(5) of this section and winding down costs pursuant to 11 CFR 9004.11...

  10. 11 CFR 9004.4 - Use of payments; examples of qualified campaign expenses and non-qualified campaign expenses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to the beginning of the expenditure report period; (4) To defray winding down costs pursuant to 11 CFR 9004.11; (5) To defray costs associated with the candidate's general election campaign paid after... payable pursuant to paragraph (a)(5) of this section and winding down costs pursuant to 11 CFR 9004.11...

  11. 76 FR 80405 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-PXI Systems...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ...; SignalCore Inc., Austin, TX; Modular Methods, LLC, Steamboat Springs, CO; and SELEX Galileo S.p.A., Roma... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...

  12. 75 FR 65657 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Alliance for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Alliance for Water Stewardship Notice is hereby given that, on September 10, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...

  13. 78 FR 54277 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cable Television...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cable Television Laboratories, Inc. Notice is hereby given that, on August 1, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...

  14. 75 FR 51114 - Notice Pursuant to The National Cooperative Research and Production Act of 1993-Pistoia Alliance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to The National Cooperative Research and Production Act of 1993--Pistoia Alliance, Inc. Notice is hereby given that, on July 13, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...

  15. 75 FR 31815 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Pistoia Alliance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Pistoia Alliance, Inc. Notice is hereby given that, on April 22, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...

  16. 78 FR 67399 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-PXI System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--PXI System Alliance, Inc. Notice is hereby given that, on October 10, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...

  17. 75 FR 51115 - Notice Pursuant to The National Cooperative Research and Production Act of 1993-PXI Systems...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to The National Cooperative Research and Production Act of 1993--PXI Systems Alliance, Inc. Notice is hereby given that, on July 8, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...

  18. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  19. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  20. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  1. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  2. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  3. 78 FR 55296 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-American Gap...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--American Gap Association Notice is hereby given that, on August 12, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...

  4. 17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

  5. 17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

  6. 17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

  7. 17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

  8. 29 CFR 71.51 - Specific exemptions pursuant to subsection (k)(2) of the Privacy Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Specific exemptions pursuant to subsection (k)(2) of the... § 71.51 Specific exemptions pursuant to subsection (k)(2) of the Privacy Act. (a) The following systems of records are eligible for exemption under 5 U.S.C. 552a(k)(2) because they contain investigatory...

  9. 29 CFR 71.52 - Specific exemptions pursuant to subsection (k)(5) of the Privacy Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Specific exemptions pursuant to subsection (k)(5) of the... § 71.52 Specific exemptions pursuant to subsection (k)(5) of the Privacy Act. (a) The following systems of records are eligible for exemption under 5 U.S.C. 552a(k)(5) because they contain investigatory...

  10. 3 CFR - Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 3 The President 1 2014-01-01 2014-01-01 false Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense Authorization Act for Fiscal Year 2012 Presidential Documents Other Presidential Documents Presidential Determination No. 2014-3 of November 29, 2013 Presidential Determination Pursuant to Section 1245(d)(4)(...

  11. 29 CFR 516.21 - Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b)(3) of the Act. 516.21 Section 516.21 Labor Regulations Relating to Labor....21 Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b...

  12. 29 CFR 516.21 - Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b)(3) of the Act. 516.21 Section 516.21 Labor Regulations Relating to Labor....21 Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b...

  13. 40 CFR 65.104 - Instrument and sensory monitoring for leaks.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (i) Valves in gas/vapor service and in light liquid service shall be monitored pursuant to § 65.106(b). (ii) Pumps in light liquid service shall be monitored pursuant to § 65.107(b). (iii) Connectors in gas/vapor service and in light liquid service shall be monitored pursuant to § 65.108(b). (iv) Agitators in...

  14. 40 CFR 65.104 - Instrument and sensory monitoring for leaks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (i) Valves in gas/vapor service and in light liquid service shall be monitored pursuant to § 65.106(b). (ii) Pumps in light liquid service shall be monitored pursuant to § 65.107(b). (iii) Connectors in gas/vapor service and in light liquid service shall be monitored pursuant to § 65.108(b). (iv) Agitators in...

  15. 76 FR 55167 - Designation of Three Individuals Pursuant to Executive Order 13573 of May 18, 2011, “Blocking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... Pursuant to Executive Order 13573 of May 18, 2011, ``Blocking Property of Senior Officials of the... individuals whose property and interests in property are blocked pursuant to Executive Order 13573 of May 18...-hour fax-on-demand service, Tel.: 202/622-0077. Background On May 18, 2011, the President issued...

  16. 78 FR 31631 - Designation of Three (3) Individuals Pursuant to Executive Order 13573 of May 18, 2011, “Blocking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Pursuant to Executive Order 13573 of May 18, 2011, ``Blocking Property of Senior Officials of the...) individuals whose property and interests in property are blocked pursuant to Executive Order 13573 of May 18..., Tel.: 202/622-0077. Background On May 18, 2011, the President issued Executive Order 13573, ``Blocking...

  17. Closed-Loop Multitarget Optimization for Discovery of New Emulsion Polymerization Recipes

    PubMed Central

    2015-01-01

    Self-optimization of chemical reactions enables faster optimization of reaction conditions or discovery of molecules with required target properties. The technology of self-optimization has been expanded to discovery of new process recipes for manufacture of complex functional products. A new machine-learning algorithm, specifically designed for multiobjective target optimization with an explicit aim to minimize the number of “expensive” experiments, guides the discovery process. This “black-box” approach assumes no a priori knowledge of chemical system and hence particularly suited to rapid development of processes to manufacture specialist low-volume, high-value products. The approach was demonstrated in discovery of process recipes for a semibatch emulsion copolymerization, targeting a specific particle size and full conversion. PMID:26435638

  18. [Frontiers in Live Bone Imaging Researches. Novel drug discovery by means of intravital bone imaging technology].

    PubMed

    Ishii, Masaru

    2015-06-01

    Recent advances in intravital bone imaging technology has enabled us to grasp the real cellular behaviors and functions in vivo , revolutionizing the field of drug discovery for novel therapeutics against intractable bone diseases. In this chapter, I introduce various updated information on pharmacological actions of several antibone resorptive agents, which could only be derived from advanced imaging techniques, and also discuss the future perspectives of this new trend in drug discovery.

  19. Balancing novelty with confined chemical space in modern drug discovery.

    PubMed

    Medina-Franco, José L; Martinez-Mayorga, Karina; Meurice, Nathalie

    2014-02-01

    The concept of chemical space has broad applications in drug discovery. In response to the needs of drug discovery campaigns, different approaches are followed to efficiently populate, mine and select relevant chemical spaces that overlap with biologically relevant chemical spaces. This paper reviews major trends in current drug discovery and their impact on the mining and population of chemical space. We also survey different approaches to develop screening libraries with confined chemical spaces balancing physicochemical properties. In this context, the confinement is guided by criteria that can be divided in two broad categories: i) library design focused on a relevant therapeutic target or disease and ii) library design focused on the chemistry or a desired molecular function. The design and development of chemical libraries should be associated with the specific purpose of the library and the project goals. The high complexity of drug discovery and the inherent imperfection of individual experimental and computational technologies prompt the integration of complementary library design and screening approaches to expedite the identification of new and better drugs. Library design approaches including diversity-oriented synthesis, biological-oriented synthesis or combinatorial library design, to name a few, and the design of focused libraries driven by target/disease, chemical structure or molecular function are more efficient if they are guided by multi-parameter optimization. In this context, consideration of pharmaceutically relevant properties is essential for balancing novelty with chemical space in drug discovery.

  20. Dual function of MG53 in membrane repair and insulin signaling

    PubMed Central

    Tan, Tao; Ko, Young-Gyu; Ma, Jianjie

    2016-01-01

    MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine. [BMB Reports 2016; 49(8): 414-423] PMID:27174502

  1. 24 CFR 203.43i - Eligibility of mortgages on Hawaiian Home Lands insured pursuant to section 247 of the National...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Hawaiian Home Lands insured pursuant to section 247 of the National Housing Act. 203.43i Section 203.43i... Eligibility of mortgages on Hawaiian Home Lands insured pursuant to section 247 of the National Housing Act. (a) Eligibility. A mortgage on a homestead lease granted by the Department of Hawaiian Home Lands...

  2. 7 CFR Appendix D to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30... 7 Agriculture 11 2010-01-01 2010-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30 D Appendix D to Subpart B of Part 1744...

  3. 77 FR 34068 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Secure Content...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Secure Content Storage Association, LLC Notice is hereby given that, on May 3, 2012, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act''), the Secure...

  4. 77 FR 47882 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cooperative Research Group on Clean Diesel VI Notice is hereby given that, on July 16, 2012, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act''),...

  5. 75 FR 66792 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cooperative Research Group on Clean Diesel V Notice is hereby given that, on October 7, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act''),...

  6. 78 FR 16571 - OFAC Implementation of Certain Sanctions Imposed on SYTROL by the Secretary of State Pursuant to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... Sanctions Imposed on SYTROL by the Secretary of State Pursuant to the Iran Sanctions Act of 1996, as Amended... sanctions imposed on SYTROL by the Secretary of State pursuant to the Iran Sanctions Act of 1996 (Pub. L. 104-172) (50 U.S.C. 1701 note) (``ISA''), as amended by the Comprehensive Iran Sanctions...

  7. 78 FR 9939 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-U.S. Photovoltaic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--U.S. Photovoltaic Manufacturing Consortium, Inc. Notice is hereby given that, on January 15, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act'')...

  8. 10 CFR 2.401 - Notice of hearing on construction permit or combined license applications pursuant to appendix N...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... pursuant to appendix N of part 50 of this chapter for construction permits for nuclear power reactors of... Procedures Applicable to Proceedings for the Issuance of Licenses To Construct and/or Operate Nuclear Power... license applications pursuant to appendix N of 10 CFR parts 50 or 52. 2.401 Section 2.401 Energy NUCLEAR...

  9. 12 CFR 614.4060 - Affiliates established pursuant to section 8.5(e)(1) of the Farm Credit Act of 1971.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Affiliates established pursuant to section 8.5... ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Lending Authorities § 614.4060 Affiliates established pursuant to section 8.5(e)(1) of the Farm Credit Act of 1971. An affiliate established by one or...

  10. 3 CFR - Delegation of Authority Pursuant to Section 404(c) of the Child Soldiers Prevention Act of 2008...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Pursuant to Section 404(c) of the Child Soldiers Prevention Act of 2008, as Amended Presidential Documents Other Presidential Documents Memorandum of August 2, 2013 Delegation of Authority Pursuant to Section 404(c) of the Child Soldiers Prevention Act of 2008, as Amended...

  11. 3 CFR - Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 3 The President 1 2014-01-01 2014-01-01 false Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense Authorization Act for Fiscal Year 2012 Presidential Documents Other Presidential Documents Presidential Determination No. 2013-10 of June 5, 2013 Presidential Determination Pursuant to Section 1245(d)(4)(B)...

  12. 3 CFR - Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 3 The President 1 2013-01-01 2013-01-01 false Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense Authorization Act for Fiscal Year 2012 Presidential Documents Other Presidential Documents Presidential Determination No. 2012-5 of March 30, 2012 Presidential Determination Pursuant to Section 1245(d)(4)(B)...

  13. 3 CFR - Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 3 The President 1 2013-01-01 2013-01-01 false Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense Authorization Act for Fiscal Year 2012 Presidential Documents Other Presidential Documents Presidential Determination No. 2013-3 of December 7, 2012 Presidential Determination Pursuant to Section 1245(d)(4)(B...

  14. 3 CFR - Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 3 The President 1 2013-01-01 2013-01-01 false Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense Authorization Act for Fiscal Year 2012 Presidential Documents Other Presidential Documents Presidential Determination No. 2012-9 of June 11, 2012 Presidential Determination Pursuant to Section 1245(d)(4)(B)...

  15. 76 FR 58540 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Open Axis Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... plaintiffs to actual damages under specified circumstances. Specifically, MindTree Limited, Bangalore, INDIA... the Federal Register pursuant to Section 6(b) of the Act on November 16, 2010 (75 FR 70031). The last... pursuant to Section 6(b) of the Act on July 7, 2011 (76 FR 39902). Patricia A. Brink, Director of Civil...

  16. 77 FR 64128 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; Advanced Media...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993; Advanced Media Workflow Association, Inc. Notice is hereby given that, on September 24, 2012, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act''),...

  17. 78 FR 27263 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing of Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... Which Mini Options Will Trade as a Complex Order Pursuant to BOX Rule 7240 May 3, 2013. Pursuant to... Change The Exchange proposes to amend BOX Rule 7240 (Complex Orders). The text of the proposed rule... provide for the manner in which Mini Options will trade as a Complex Order pursuant to BOX Rule [[Page...

  18. 78 FR 79498 - Notice Pursuant to The National Cooperative Research and Production Act of 1993-IMS Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to The National Cooperative Research and Production Act of 1993--IMS Global Learning Consortium, Inc. Notice is hereby given that, on November 22, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. Sec. 4301 et seq. (``the Act''), IMS...

  19. 28 CFR 50.10 - Policy regarding obtaining information from, or records of, members of the news media; and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... views the use of certain law enforcement tools, including subpoenas, court orders issued pursuant to 18... court orders issued pursuant to 18 U.S.C. 2703(d) or 3123, in particular, may be used, after... use of a subpoena, court order issued pursuant to 18 U.S.C. 2703(d) or 3123, or warrant to obtain from...

  20. 7 CFR Appendix D to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30 D Appendix D to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  1. 7 CFR Appendix D to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30 D Appendix D to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  2. 7 CFR Appendix D to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30 D Appendix D to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  3. 7 CFR Appendix D to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30 D Appendix D to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  4. Forecasting petroleum discoveries in sparsely drilled areas: Nigeria and the North Sea

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Attanasi, E.D.; Root, D.H.

    1988-10-01

    Decline function methods for projecting future discoveries generally capture the crowding effects of wildcat wells on the discovery rate. However, these methods do not accommodate easily situations where exploration areas and horizons are expanding. In this paper, a method is presented that uses a mapping algorithm for separating these often countervailing influences. The method is applied to Nigeria and the North Sea. For an amount of future drilling equivalent to past drilling (825 wildcat wells), future discoveries (in resources found) for Nigeria are expected to decline by 68% per well but still amount to 8.5 billion barrels of oil equivalentmore » (BOE). Similarly, for the total North Sea for an equivalent amount and mix among areas of past drilling (1322 wildcat wells), future discoveries are expected to amount to 17.9 billion BOE, whereas the average discovery rate per well is expected to decline by 71%.« less

  5. Forecasting petroleum discoveries in sparsely drilled areas: Nigeria and the North Sea

    USGS Publications Warehouse

    Attanasi, E.D.; Root, D.H.

    1988-01-01

    Decline function methods for projecting future discoveries generally capture the crowding effects of wildcat wells on the discovery rate. However, these methods do not accommodate easily situations where exploration areas and horizons are expanding. In this paper, a method is presented that uses a mapping algorithm for separating these often countervailing influences. The method is applied to Nigeria and the North Sea. For an amount of future drilling equivalent to past drilling (825 wildcat wells), future discoveries (in resources found) for Nigeria are expected to decline by 68% per well but still amount to 8.5 billion barrels of oil equivalent (BOE). Similarly, for the total North Sea for an equivalent amount and mix among areas of past drilling (1322 wildcat wells), future discoveries are expected to amount to 17.9 billion BOE, whereas the average discovery rate per well is expected to decline by 71%. ?? 1988 International Association for Mathematical Geology.

  6. Functional Metagenomics: Construction and High-Throughput Screening of Fosmid Libraries for Discovery of Novel Carbohydrate-Active Enzymes.

    PubMed

    Ufarté, Lisa; Bozonnet, Sophie; Laville, Elisabeth; Cecchini, Davide A; Pizzut-Serin, Sandra; Jacquiod, Samuel; Demanèche, Sandrine; Simonet, Pascal; Franqueville, Laure; Veronese, Gabrielle Potocki

    2016-01-01

    Activity-based metagenomics is one of the most efficient approaches to boost the discovery of novel biocatalysts from the huge reservoir of uncultivated bacteria. In this chapter, we describe a highly generic procedure of metagenomic library construction and high-throughput screening for carbohydrate-active enzymes. Applicable to any bacterial ecosystem, it enables the swift identification of functional enzymes that are highly efficient, alone or acting in synergy, to break down polysaccharides and oligosaccharides.

  7. 7 CFR Appendix B to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30... 7 Agriculture 11 2010-01-01 2010-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(c) B Appendix B to Subpart B of Part 1744...

  8. 29 CFR 516.33 - Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Employees employed in agriculture pursuant to section 13(a....33 Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act. (a) No... the number of weeks employed in agriculture during the preceding calendar year. (e) With respect to...

  9. 29 CFR 516.33 - Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Employees employed in agriculture pursuant to section 13(a....33 Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act. (a) No... the number of weeks employed in agriculture during the preceding calendar year. (e) With respect to...

  10. 29 CFR 516.33 - Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Employees employed in agriculture pursuant to section 13(a....33 Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act. (a) No... the number of weeks employed in agriculture during the preceding calendar year. (e) With respect to...

  11. 29 CFR 516.33 - Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Employees employed in agriculture pursuant to section 13(a....33 Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act. (a) No... the number of weeks employed in agriculture during the preceding calendar year. (e) With respect to...

  12. 29 CFR 516.33 - Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Employees employed in agriculture pursuant to section 13(a....33 Employees employed in agriculture pursuant to section 13(a)(6) or 13(b)(12) of the Act. (a) No... the number of weeks employed in agriculture during the preceding calendar year. (e) With respect to...

  13. 3 CFR - Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims Protection Act of 2000, as Amended Presidential Documents Other Presidential Documents Memorandum of July 29, 2013 Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims...

  14. 3 CFR - Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 3 The President 1 2013-01-01 2013-01-01 false Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims Protection Act of 2000, as Amended Presidential Documents Other Presidential Documents Memorandum of February 3, 2012 Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking...

  15. 31 CFR 594.517 - Payments from funds originating outside the United States and the formation of legal defense...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... interests in property are blocked pursuant to § 594.201(a), the U.S. person that is an attorney, law firm... property and interests in property are blocked pursuant to any part of this chapter or any Executive order... whose property and interests in property are blocked pursuant to § 594.201(a) or any other part of this...

  16. 31 CFR 594.517 - Payments from funds originating outside the United States and the formation of legal defense...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... interests in property are blocked pursuant to § 594.201(a), the U.S. person that is an attorney, law firm... property and interests in property are blocked pursuant to any part of this chapter or any Executive order... whose property and interests in property are blocked pursuant to § 594.201(a) or any other part of this...

  17. 31 CFR 594.517 - Payments from funds originating outside the United States and the formation of legal defense...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... interests in property are blocked pursuant to § 594.201(a), the U.S. person that is an attorney, law firm... property and interests in property are blocked pursuant to any part of this chapter or any Executive order... whose property and interests in property are blocked pursuant to § 594.201(a) or any other part of this...

  18. 31 CFR 594.517 - Payments from funds originating outside the United States and the formation of legal defense...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... interests in property are blocked pursuant to § 594.201(a), the U.S. person that is an attorney, law firm... property and interests in property are blocked pursuant to any part of this chapter or any Executive order... whose property and interests in property are blocked pursuant to § 594.201(a) or any other part of this...

  19. 7 CFR Appendix B to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(c) B Appendix B to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  20. 7 CFR Appendix B to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(c) B Appendix B to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  1. 7 CFR Appendix B to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(c) B Appendix B to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  2. 7 CFR Appendix B to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(c) B Appendix B to Subpart B of Part 1744...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30...

  3. Applying ADLs to Assess Emerging Industry Specifications for Dynamic Discovery of Ad Hoc Network Services

    DTIC Science & Technology

    2001-01-31

    function of Jini, UPnP, SLP, Bluetooth , and HAVi • Projected specific UML models for Jini, UPnP, and SLP • Developed a Rapide Model of Jini...is used by all JINI entities in directed -- discovery mode. It is part of the SCM_Discovery -- Module. Sends Unicast messages to SCMs on list of... SCMS to be discovered until all SCMS are found. -- Receives updates from SCM DB of discovered SCMs and -- removes SCMs accordingly -- NOTE

  4. BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation

    PubMed Central

    2011-01-01

    We present BioGraph, a data integration and data mining platform for the exploration and discovery of biomedical information. The platform offers prioritizations of putative disease genes, supported by functional hypotheses. We show that BioGraph can retrospectively confirm recently discovered disease genes and identify potential susceptibility genes, outperforming existing technologies, without requiring prior domain knowledge. Additionally, BioGraph allows for generic biomedical applications beyond gene discovery. BioGraph is accessible at http://www.biograph.be. PMID:21696594

  5. Biological Awareness: Statements for Self-Discovery.

    ERIC Educational Resources Information Center

    Edington, D.W.; Cunningham, Lee

    This guide to biological awareness through guided self-discovery is based on 51 single focus statements concerning the human body. For each statement there are explanations of the underlying physiological principles and suggested activities and discussion ideas to encourage understanding of the statement in terms of the human body's functions,…

  6. From Mere Coincidences to Meaningful Discoveries

    ERIC Educational Resources Information Center

    Griffiths, Thomas L.; Tenenbaum, Joshua B.

    2007-01-01

    People's reactions to coincidences are often cited as an illustration of the irrationality of human reasoning about chance. We argue that coincidences may be better understood in terms of rational statistical inference, based on their functional role in processes of causal discovery and theory revision. We present a formal definition of…

  7. CTD² Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network* | Office of Cancer Genomics

    Cancer.gov

    The Cancer Target Discovery and Development (CTD2) Network aims to use functional genomics to accelerate the translation of high-throughput and high-content genomic and small-molecule data towards use in precision oncology.

  8. How the discovery of ribozymes cast RNA in the roles of both chicken and egg in origin-of-life theories.

    PubMed

    Sankaran, Neeraja

    2012-12-01

    Scientific theories about the origin-of-life theories have historically been characterized by the chicken-and-egg problem of which essential aspect of life was the first to appear, replication or self-sustenance. By the 1950s the question was cast in molecular terms and DNA and proteins had come to represent the carriers of the two functions. Meanwhile, RNA, the other nucleic acid, had played a capricious role in origin theories. Because it contained building blocks very similar to DNA, biologists recognized early that RNA could store information in its linear sequences. With the discovery in the 1980s that RNA molecules were capable of biological catalysis, a function hitherto ascribed to proteins alone, RNA took on the role of the single entity that could act as both chicken and egg. Within a few years of the discovery of these catalytic RNAs (ribozymes) scientists had formulated an RNA World hypothesis that posited an early phase in the evolution of life where all key functions were performed by RNA molecules. This paper traces the history the role of RNA in origin-of-life theories with a focus on how the discovery of ribozymes influenced the discourse. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches.

    PubMed

    Lee, Jonathan A; Berg, Ellen L

    2013-12-01

    Innovation and new molecular entity production by the pharmaceutical industry has been below expectations. Surprisingly, more first-in-class small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) between 1999 and 2008 were identified by functional phenotypic lead generation strategies reminiscent of pre-genomics pharmacology than contemporary molecular targeted strategies that encompass the vast majority of lead generation efforts. This observation, in conjunction with the difficulty in validating molecular targets for drug discovery, has diminished the impact of the "genomics revolution" and has led to a growing grassroots movement and now broader trend in pharma to reconsider the use of modern physiology-based or phenotypic drug discovery (PDD) strategies. This "From the Guest Editors" column provides an introduction and overview of the two-part special issues of Journal of Biomolecular Screening on PDD. Terminology and the business case for use of PDD are defined. Key issues such as assay performance, chemical optimization, target identification, and challenges to the organization and implementation of PDD are discussed. Possible solutions for these challenges and a new neoclassic vision for PDD that combines phenotypic and functional approaches with technology innovations resulting from the genomics-driven era of target-based drug discovery (TDD) are also described. Finally, an overview of the manuscripts in this special edition is provided.

  10. Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications

    PubMed Central

    Castillo, Jonathan; Stueve, Theresa R.; Marconett, Crystal N.

    2017-01-01

    Previously thought of as junk transcripts and pseudogene remnants, long non-coding RNAs (lncRNAs) have come into their own over the last decade as an essential component of cellular activity, regulating a plethora of functions within multicellular organisms. lncRNAs are now known to participate in development, cellular homeostasis, immunological processes, and the development of disease. With the advent of next generation sequencing technology, hundreds of thousands of lncRNAs have been identified. However, movement beyond mere discovery to the understanding of molecular processes has been stymied by the complicated genomic structure, tissue-restricted expression, and diverse regulatory roles lncRNAs play. In this review, we will focus on lncRNAs involved in lung cancer, the most common cause of cancer-related death in the United States and worldwide. We will summarize their various methods of discovery, provide consensus rankings of deregulated lncRNAs in lung cancer, and describe in detail the limited functional analysis that has been undertaken so far. PMID:29113413

  11. The discovery of human auditory-motor entrainment and its role in the development of neurologic music therapy.

    PubMed

    Thaut, Michael H

    2015-01-01

    The discovery of rhythmic auditory-motor entrainment in clinical populations was a historical breakthrough in demonstrating for the first time a neurological mechanism linking music to retraining brain and behavioral functions. Early pilot studies from this research center were followed up by a systematic line of research studying rhythmic auditory stimulation on motor therapies for stroke, Parkinson's disease, traumatic brain injury, cerebral palsy, and other movement disorders. The comprehensive effects on improving multiple aspects of motor control established the first neuroscience-based clinical method in music, which became the bedrock for the later development of neurologic music therapy. The discovery of entrainment fundamentally shifted and extended the view of the therapeutic properties of music from a psychosocially dominated view to a view using the structural elements of music to retrain motor control, speech and language function, and cognitive functions such as attention and memory. © 2015 Elsevier B.V. All rights reserved.

  12. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.

    PubMed

    Kollmann, Christopher S; Bai, Xiaopeng; Tsai, Ching-Hsuan; Yang, Hongfang; Lind, Kenneth E; Skinner, Steven R; Zhu, Zhengrong; Israel, David I; Cuozzo, John W; Morgan, Barry A; Yuki, Koichi; Xie, Can; Springer, Timothy A; Shimaoka, Motomu; Evindar, Ghotas

    2014-04-01

    The inhibition of protein-protein interactions remains a challenge for traditional small molecule drug discovery. Here we describe the use of DNA-encoded library technology for the discovery of small molecules that are potent inhibitors of the interaction between lymphocyte function-associated antigen 1 and its ligand intercellular adhesion molecule 1. A DNA-encoded library with a potential complexity of 4.1 billion compounds was exposed to the I-domain of the target protein and the bound ligands were affinity selected, yielding an enriched small-molecule hit family. Compounds representing this family were synthesized without their DNA encoding moiety and found to inhibit the lymphocyte function-associated antigen 1/intercellular adhesion molecule-1 interaction with submicromolar potency in both ELISA and cell adhesion assays. Re-synthesized compounds conjugated to DNA or a fluorophore were demonstrated to bind to cells expressing the target protein. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Integrated Computational Analysis of Genes Associated with Human Hereditary Insensitivity to Pain. A Drug Repurposing Perspective

    PubMed Central

    Lötsch, Jörn; Lippmann, Catharina; Kringel, Dario; Ultsch, Alfred

    2017-01-01

    Genes causally involved in human insensitivity to pain provide a unique molecular source of studying the pathophysiology of pain and the development of novel analgesic drugs. The increasing availability of “big data” enables novel research approaches to chronic pain while also requiring novel techniques for data mining and knowledge discovery. We used machine learning to combine the knowledge about n = 20 genes causally involved in human hereditary insensitivity to pain with the knowledge about the functions of thousands of genes. An integrated computational analysis proposed that among the functions of this set of genes, the processes related to nervous system development and to ceramide and sphingosine signaling pathways are particularly important. This is in line with earlier suggestions to use these pathways as therapeutic target in pain. Following identification of the biological processes characterizing hereditary insensitivity to pain, the biological processes were used for a similarity analysis with the functions of n = 4,834 database-queried drugs. Using emergent self-organizing maps, a cluster of n = 22 drugs was identified sharing important functional features with hereditary insensitivity to pain. Several members of this cluster had been implicated in pain in preclinical experiments. Thus, the present concept of machine-learned knowledge discovery for pain research provides biologically plausible results and seems to be suitable for drug discovery by identifying a narrow choice of repurposing candidates, demonstrating that contemporary machine-learned methods offer innovative approaches to knowledge discovery from available evidence. PMID:28848388

  14. 29 CFR 102.95 - Priority of cases pursuant to section 10(l) and (m) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Priority of cases pursuant to section 10(l) and (m) of the... AND REGULATIONS, SERIES 8 Procedure in Cases Under Section 10(j), (l), and (m) of the Act § 102.95 Priority of cases pursuant to section 10(l) and (m) of the Act. (a) Whenever a charge is filed alleging the...

  15. 29 CFR 102.95 - Priority of cases pursuant to section 10(l) and (m) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Priority of cases pursuant to section 10(l) and (m) of the... AND REGULATIONS, SERIES 8 Procedure in Cases Under Section 10(j), (l), and (m) of the Act § 102.95 Priority of cases pursuant to section 10(l) and (m) of the Act. (a) Whenever a charge is filed alleging the...

  16. Process model-based atomic service discovery and composition of composite semantic web services using web ontology language for services (OWL-S)

    NASA Astrophysics Data System (ADS)

    Paulraj, D.; Swamynathan, S.; Madhaiyan, M.

    2012-11-01

    Web Service composition has become indispensable as a single web service cannot satisfy complex functional requirements. Composition of services has received much interest to support business-to-business (B2B) or enterprise application integration. An important component of the service composition is the discovery of relevant services. In Semantic Web Services (SWS), service discovery is generally achieved by using service profile of Ontology Web Languages for Services (OWL-S). The profile of the service is a derived and concise description but not a functional part of the service. The information contained in the service profile is sufficient for atomic service discovery, but it is not sufficient for the discovery of composite semantic web services (CSWS). The purpose of this article is two-fold: first to prove that the process model is a better choice than the service profile for service discovery. Second, to facilitate the composition of inter-organisational CSWS by proposing a new composition method which uses process ontology. The proposed service composition approach uses an algorithm which performs a fine grained match at the level of atomic process rather than at the level of the entire service in a composite semantic web service. Many works carried out in this area have proposed solutions only for the composition of atomic services and this article proposes a solution for the composition of composite semantic web services.

  17. 12 CFR 265.9 - Functions delegated to the Director of Division of Consumer and Community Affairs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...), 814(c), and 917(b) of the Consumer Credit Protection Act (15 U.S.C. 1607(b), 1681s(b), 1691c(b), 1692l... responsibilities in connection with: (1) Sections 1-200 and 501-921 of the Consumer Credit Protection Act (15 U.S.C... Advisory Council. Pursuant to section 703(b) of the Consumer Credit Protection Act (15 U.S.C. 1691b(b)), to...

  18. Genomics and transcriptomics in drug discovery.

    PubMed

    Dopazo, Joaquin

    2014-02-01

    The popularization of genomic high-throughput technologies is causing a revolution in biomedical research and, particularly, is transforming the field of drug discovery. Systems biology offers a framework to understand the extensive human genetic heterogeneity revealed by genomic sequencing in the context of the network of functional, regulatory and physical protein-drug interactions. Thus, approaches to find biomarkers and therapeutic targets will have to take into account the complex system nature of the relationships of the proteins with the disease. Pharmaceutical companies will have to reorient their drug discovery strategies considering the human genetic heterogeneity. Consequently, modeling and computational data analysis will have an increasingly important role in drug discovery. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Open Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field.

    PubMed

    Wójcikowski, Maciej; Zielenkiewicz, Piotr; Siedlecki, Pawel

    2015-01-01

    There has been huge progress in the open cheminformatics field in both methods and software development. Unfortunately, there has been little effort to unite those methods and software into one package. We here describe the Open Drug Discovery Toolkit (ODDT), which aims to fulfill the need for comprehensive and open source drug discovery software. The Open Drug Discovery Toolkit was developed as a free and open source tool for both computer aided drug discovery (CADD) developers and researchers. ODDT reimplements many state-of-the-art methods, such as machine learning scoring functions (RF-Score and NNScore) and wraps other external software to ease the process of developing CADD pipelines. ODDT is an out-of-the-box solution designed to be easily customizable and extensible. Therefore, users are strongly encouraged to extend it and develop new methods. We here present three use cases for ODDT in common tasks in computer-aided drug discovery. Open Drug Discovery Toolkit is released on a permissive 3-clause BSD license for both academic and industrial use. ODDT's source code, additional examples and documentation are available on GitHub (https://github.com/oddt/oddt).

  20. Early Probe and Drug Discovery in Academia: A Minireview.

    PubMed

    Roy, Anuradha

    2018-02-09

    Drug discovery encompasses processes ranging from target selection and validation to the selection of a development candidate. While comprehensive drug discovery work flows are implemented predominantly in the big pharma domain, early discovery focus in academia serves to identify probe molecules that can serve as tools to study targets or pathways. Despite differences in the ultimate goals of the private and academic sectors, the same basic principles define the best practices in early discovery research. A successful early discovery program is built on strong target definition and validation using a diverse set of biochemical and cell-based assays with functional relevance to the biological system being studied. The chemicals identified as hits undergo extensive scaffold optimization and are characterized for their target specificity and off-target effects in in vitro and in animal models. While the active compounds from screening campaigns pass through highly stringent chemical and Absorption, Distribution, Metabolism, and Excretion (ADME) filters for lead identification, the probe discovery involves limited medicinal chemistry optimization. The goal of probe discovery is identification of a compound with sub-µM activity and reasonable selectivity in the context of the target being studied. The compounds identified from probe discovery can also serve as starting scaffolds for lead optimization studies.

  1. Modeling & Informatics at Vertex Pharmaceuticals Incorporated: our philosophy for sustained impact

    NASA Astrophysics Data System (ADS)

    McGaughey, Georgia; Patrick Walters, W.

    2017-03-01

    Molecular modelers and informaticians have the unique opportunity to integrate cross-functional data using a myriad of tools, methods and visuals to generate information. Using their drug discovery expertise, information is transformed to knowledge that impacts drug discovery. These insights are often times formulated locally and then applied more broadly, which influence the discovery of new medicines. This is particularly true in an organization where the members are exposed to projects throughout an organization, such as in the case of the global Modeling & Informatics group at Vertex Pharmaceuticals. From its inception, Vertex has been a leader in the development and use of computational methods for drug discovery. In this paper, we describe the Modeling & Informatics group at Vertex and the underlying philosophy, which has driven this team to sustain impact on the discovery of first-in-class transformative medicines.

  2. The ``Missing Compounds'' affair in functionality-driven material discovery

    NASA Astrophysics Data System (ADS)

    Zunger, Alex

    2014-03-01

    In the paradigm of ``data-driven discovery,'' underlying one of the leading streams of the Material Genome Initiative (MGI), one attempts to compute high-throughput style as many of the properties of as many of the N (about 10**5- 10**6) compounds listed in databases of previously known compounds. One then inspects the ensuing Big Data, searching for useful trends. The alternative and complimentary paradigm of ``functionality-directed search and optimization'' used here, searches instead for the n much smaller than N configurations and compositions that have the desired value of the target functionality. Examples include the use of genetic and other search methods that optimize the structure or identity of atoms on lattice sites, using atomistic electronic structure (such as first-principles) approaches in search of a given electronic property. This addresses a few of the bottlenecks that have faced the alternative, data-driven/high throughput/Big Data philosophy: (i) When the configuration space is theoretically of infinite size, building a complete data base as in data-driven discovery is impossible, yet searching for the optimum functionality, is still a well-posed problem. (ii) The configuration space that we explore might include artificially grown, kinetically stabilized systems (such as 2D layer stacks; superlattices; colloidal nanostructures; Fullerenes) that are not listed in compound databases (used by data-driven approaches), (iii) a large fraction of chemically plausible compounds have not been experimentally synthesized, so in the data-driven approach these are often skipped. In our approach we search explicitly for such ``Missing Compounds''. It is likely that many interesting material properties will be found in cases (i)-(iii) that elude high throughput searches based on databases encapsulating existing knowledge. I will illustrate (a) Functionality-driven discovery of topological insulators and valley-split quantum-computer semiconductors, as well as (b) Use of ``first principles thermodynamics'' to discern which of the previously ``missing compounds'' should, in fact exist and in which structure. Synthesis efforts by Poeppelmeier group at NU realized 20 never-before-made half-Heusler compounds out of the 20 predicted ones, in our predicted space groups. This type of theory-led experimental search of designed materials with target functionalities may shorten the current process of discovery of interesting functional materials. Supported by DOE ,Office of Science, Energy Frontier Research Center for Inverse Design

  3. Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc.

    PubMed

    Price, David A; Armour, Duncan; de Groot, Marcel; Leishman, Derek; Napier, Carolyn; Perros, Manos; Stammen, Blanda L; Wood, Anthony

    2006-09-01

    The discovery of maraviroc 17 is described with particular reference to the generation of high selectivity over affinity for the HERG potassium channel. This was achieved through the use of a high throughput binding assay for the HERG channel that is known to show an excellent correlation with functional effects.

  4. Some Applications of Fourier's Great Discovery for Beginners

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2012-01-01

    Nearly two centuries ago, Fourier discovered that any periodic function of period T can be presented as a sum of sine waveforms of frequencies equal to an integer times the fundamental frequency [omega] = 2[pi]/T (Fourier's series). It is impossible to overestimate the importance of Fourier's discovery, and all physics or engineering students…

  5. Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform.

    PubMed

    Foltz, Ian N; Gunasekaran, Kannan; King, Chadwick T

    2016-03-01

    Since the late 1990s, the use of transgenic animal platforms has transformed the discovery of fully human therapeutic monoclonal antibodies. The first approved therapy derived from a transgenic platform--the epidermal growth factor receptor antagonist panitumumab to treat advanced colorectal cancer--was developed using XenoMouse(®) technology. Since its approval in 2006, the science of discovering and developing therapeutic monoclonal antibodies derived from the XenoMouse(®) platform has advanced considerably. The emerging array of antibody therapeutics developed using transgenic technologies is expected to include antibodies and antibody fragments with novel mechanisms of action and extreme potencies. In addition to these impressive functional properties, these antibodies will be designed to have superior biophysical properties that enable highly efficient large-scale manufacturing methods. Achieving these new heights in antibody drug discovery will ultimately bring better medicines to patients. Here, we review best practices for the discovery and bio-optimization of monoclonal antibodies that fit functional design goals and meet high manufacturing standards. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Ebolaviruses: New roles for old proteins.

    PubMed

    Cantoni, Diego; Rossman, Jeremy S

    2018-05-01

    In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein's primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity.

  7. Ebolaviruses: New roles for old proteins

    PubMed Central

    2018-01-01

    In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein’s primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity. PMID:29723187

  8. Bion's discovery of alpha function: thinking under fire on the battlefield and in the consulting room.

    PubMed

    Brown, Lawrence J

    2012-10-01

    This paper has traced Bion's discovery of alpha function and its subsequent elaboration. His traumatic experiences as a young tank commander in World War I (overlaid on, and intertwined with, childhood conflicts) gave him firsthand exposure to very painful emotions that tested his capacity to manage. Later, in the 1950s, after his analysis with Melanie Klein and marriage to Francesca Bion, he undertook the analysis of psychotic patients and learned how they disassembled their ability to know reality as a defense against unbearable emotional truths in their lives. This led Bion to identify an aspect of dreaming that was necessary in order for reality experience to be given personal meaning so that one may learn from experience. Simultaneous with working out this new theory of dreaming, Bion also revisited his World War I experiences that had remained undigested and all these elements coalesced into a selected fact - his discovery of alpha function. In subsequent writings, Bion explored the constituent factors of alpha function, including the container/contained relationship, the PS↔D balance, reverie, tolerated doubt and other factors which I have termed the 'Constellation for Thinking'. Copyright © 2012 Institute of Psychoanalysis.

  9. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.

    PubMed

    Murphy, Dennis L; Fox, Meredith A; Timpano, Kiara R; Moya, Pablo R; Ren-Patterson, Renee; Andrews, Anne M; Holmes, Andrew; Lesch, Klaus-Peter; Wendland, Jens R

    2008-11-01

    Discovered and crystallized over sixty years ago, serotonin's important functions in the brain and body were identified over the ensuing years by neurochemical, physiological and pharmacological investigations. This 2008 M. Rapport Memorial Serotonin Review focuses on some of the most recent discoveries involving serotonin that are based on genetic methodologies. These include examples of the consequences that result from direct serotonergic gene manipulation (gene deletion or overexpression) in mice and other species; an evaluation of some phenotypes related to functional human serotonergic gene variants, particularly in SLC6A4, the serotonin transporter gene; and finally, a consideration of the pharmacogenomics of serotonergic drugs with respect to both their therapeutic actions and side effects. The serotonin transporter (SERT) has been the most comprehensively studied of the serotonin system molecular components, and will be the primary focus of this review. We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species.

  10. 7 CFR 959.17 - District.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ONIONS GROWN IN SOUTH TEXAS Order... production area initially established pursuant to § 959.24 or as reestablished pursuant to § 959.25. ...

  11. Understanding price discovery in interconnected markets: Generalized Langevin process approach and simulation

    NASA Astrophysics Data System (ADS)

    Schenck, Natalya A.; Horvath, Philip A.; Sinha, Amit K.

    2018-02-01

    While the literature on price discovery process and information flow between dominant and satellite market is exhaustive, most studies have applied an approach that can be traced back to Hasbrouck (1995) or Gonzalo and Granger (1995). In this paper, however, we propose a Generalized Langevin process with asymmetric double-well potential function, with co-integrated time series and interconnected diffusion processes to model the information flow and price discovery process in two, a dominant and a satellite, interconnected markets. A simulated illustration of the model is also provided.

  12. Assessing Adaptive Functioning in Death Penalty Cases after Hall and DSM-5.

    PubMed

    Hagan, Leigh D; Drogin, Eric Y; Guilmette, Thomas J

    2016-03-01

    DSM-5 and Hall v. Florida (2014) have dramatically refocused attention on the assessment of adaptive functioning in death penalty cases. In this article, we address strategies for assessing the adaptive functioning of defendants who seek exemption from capital punishment pursuant to Atkins v. Virginia (2002). In particular, we assert that evaluations of adaptive functioning should address assets as well as deficits; seek to identify credible and reliable evidence concerning the developmental period and across the lifespan; distinguish incapacity from the mere absence of adaptive behavior; adhere faithfully to test manual instructions for using standardized measures of adaptive functioning; and account for potential bias on the part of informants. We conclude with brief caveats regarding the standard error of measurement (SEM) in light of Hall, with reference to examples of ordinary life activities that directly illuminate adaptive functioning relevant to capital cases. © 2016 American Academy of Psychiatry and the Law.

  13. 17 CFR 200.30-3 - Delegation of authority to Director of Division of Trading and Markets.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... pursuant to paragraph (a)(7) of that rule. (5) Pursuant to Rule 17a-5(1)(3) (§ 240.17a-5(1)(3) of this....102, 242.104, and 242.105 of this chapter). (7) Pursuant to Rule 15c3-1 (§ 240.15c3-1 of this chapter... purposes of Rule 15c3-3(c)(7) (§ 240.15c3-3(c)(7) of this chapter) certain broker-dealer accounts which are...

  14. 17 CFR 249.220f - Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g), annual and transition reports pursuant to sections 13 and 15(d), and shell company reports required under Rule 13a-19 or 15d-19 (§ 240.13a-19 or § 240.15d-19 of this chapter). 24...

  15. 17 CFR 249.220f - Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g), annual and transition reports pursuant to sections 13 and 15(d), and shell company reports required under Rule 13a-19 or 15d-19 (§ 240.13a-19 or § 240.15d-19 of this chapter). 24...

  16. 17 CFR 249.220f - Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g), annual and transition reports pursuant to sections 13 and 15(d), and shell company reports required under Rule 13a-19 or 15d-19 (§ 240.13a-19 or § 240.15d-19 of this chapter). 24...

  17. 17 CFR 249.220f - Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g), annual and transition reports pursuant to sections 13 and 15(d), and shell company reports required under Rule 13a-19 or 15d-19 (§ 240.13a-19 or § 240.15d-19 of this chapter). 24...

  18. 17 CFR 249.220f - Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Form 20-F, registration of securities of foreign private issuers pursuant to section 12(b) or (g), annual and transition reports pursuant to sections 13 and 15(d), and shell company reports required under Rule 13a-19 or 15d-19 (§ 240.13a-19 or § 240.15d-19 of this chapter). 24...

  19. Discovery of the porcine NGN3 gene and testing its endocrine function in the pig

    USDA-ARS?s Scientific Manuscript database

    Neurogenin 3 (NGN3) is a member of the basic helix-loop-helix transcription factor family. NGN3 is both necessary and sufficient to drive endocrine differentiation in the developing pancreas in mouse and humans. Until now, the sequence for NGN3 eluded discovery despite completion of the pig genome a...

  20. 22 CFR 40.22 - Multiple criminal convictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... United States, by the former High Commissioner for Germany acting pursuant to Executive Order 10062, or by the United States Ambassador to the Federal Republic of Germany acting pursuant to Executive Order...

  1. 22 CFR 40.22 - Multiple criminal convictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... United States, by the former High Commissioner for Germany acting pursuant to Executive Order 10062, or by the United States Ambassador to the Federal Republic of Germany acting pursuant to Executive Order...

  2. 22 CFR 40.22 - Multiple criminal convictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... United States, by the former High Commissioner for Germany acting pursuant to Executive Order 10062, or by the United States Ambassador to the Federal Republic of Germany acting pursuant to Executive Order...

  3. 22 CFR 40.22 - Multiple criminal convictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... United States, by the former High Commissioner for Germany acting pursuant to Executive Order 10062, or by the United States Ambassador to the Federal Republic of Germany acting pursuant to Executive Order...

  4. The re-emergence of natural products for drug discovery in the genomics era.

    PubMed

    Harvey, Alan L; Edrada-Ebel, RuAngelie; Quinn, Ronald J

    2015-02-01

    Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced these barriers. We also assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products, and highlight recent examples of natural products in antimicrobial drug discovery and as inhibitors of protein-protein interactions. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery.

  5. 76 FR 47651 - Transfer and Redesignation of Certain Regulations Involving State Savings Associations Pursuant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ...Title III of the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (the Dodd-Frank Act or the Act) provided that the functions, powers, and duties of the Office of Thrift Supervision (OTS) relating to State savings associations will transfer to the FDIC effective one year after July 21, 2010, the date that the Dodd-Frank Act was enacted. The Act also amended section 3 of the Federal Deposit Insurance Act (FDI Act) to designate the FDIC as the ``appropriate Federal banking agency'' for State savings associations. The FDIC is authorized to issue regulations pursuant to the FDI Act and other existing laws as the ``appropriate Federal banking agency'' (or under similar statutory terminology). As a result, pursuant to those laws, the FDIC, the newly-designated ``appropriate Federal banking agency'' for State savings associations, is authorized to issue certain regulations involving State savings associations. Consistent with the authority provided to the FDIC by the Dodd- Frank Act, the FDI Act, and other statutory authorities, the FDIC is reissuing and redesigning certain transferring OTS regulations. In republishing these rules, the FDIC is making only technical changes to existing OTS regulations (such as nomenclature or address changes). The FDIC is not republishing those OTS regulations for which other appropriate Federal banking agencies are authorized to act. In the future, the FDIC may take other actions related to the transferred rules: Incorporating them into other FDIC regulations contained in Title 12, Chapter III, amending them, or rescinding them, as appropriate.

  6. 76 FR 45335 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... of the United States who make remittances to persons in Cuba pursuant to the general licenses in 515..., unlimited remittances to religious organizations, remittances to students in Cuba pursuant to an educational...

  7. RNA Interference for Functional Genomics and Improvement of Cotton (Gossypium sp.)

    PubMed Central

    Abdurakhmonov, Ibrokhim Y.; Ayubov, Mirzakamol S.; Ubaydullaeva, Khurshida A.; Buriev, Zabardast T.; Shermatov, Shukhrat E.; Ruziboev, Haydarali S.; Shapulatov, Umid M.; Saha, Sukumar; Ulloa, Mauricio; Yu, John Z.; Percy, Richard G.; Devor, Eric J.; Sharma, Govind C.; Sripathi, Venkateswara R.; Kumpatla, Siva P.; van der Krol, Alexander; Kater, Hake D.; Khamidov, Khakimdjan; Salikhov, Shavkat I.; Jenkins, Johnie N.; Abdukarimov, Abdusattor; Pepper, Alan E.

    2016-01-01

    RNA interference (RNAi), is a powerful new technology in the discovery of genetic sequence functions, and has become a valuable tool for functional genomics of cotton (Gossypium sp.). The rapid adoption of RNAi has replaced previous antisense technology. RNAi has aided in the discovery of function and biological roles of many key cotton genes involved in fiber development, fertility and somatic embryogenesis, resistance to important biotic and abiotic stresses, and oil and seed quality improvements as well as the key agronomic traits including yield and maturity. Here, we have comparatively reviewed seminal research efforts in previously used antisense approaches and currently applied breakthrough RNAi studies in cotton, analyzing developed RNAi methodologies, achievements, limitations, and future needs in functional characterizations of cotton genes. We also highlighted needed efforts in the development of RNAi-based cotton cultivars, and their safety and risk assessment, small and large-scale field trials, and commercialization. PMID:26941765

  8. RNA Interference for Functional Genomics and Improvement of Cotton (Gossypium sp.).

    PubMed

    Abdurakhmonov, Ibrokhim Y; Ayubov, Mirzakamol S; Ubaydullaeva, Khurshida A; Buriev, Zabardast T; Shermatov, Shukhrat E; Ruziboev, Haydarali S; Shapulatov, Umid M; Saha, Sukumar; Ulloa, Mauricio; Yu, John Z; Percy, Richard G; Devor, Eric J; Sharma, Govind C; Sripathi, Venkateswara R; Kumpatla, Siva P; van der Krol, Alexander; Kater, Hake D; Khamidov, Khakimdjan; Salikhov, Shavkat I; Jenkins, Johnie N; Abdukarimov, Abdusattor; Pepper, Alan E

    2016-01-01

    RNA interference (RNAi), is a powerful new technology in the discovery of genetic sequence functions, and has become a valuable tool for functional genomics of cotton (Gossypium sp.). The rapid adoption of RNAi has replaced previous antisense technology. RNAi has aided in the discovery of function and biological roles of many key cotton genes involved in fiber development, fertility and somatic embryogenesis, resistance to important biotic and abiotic stresses, and oil and seed quality improvements as well as the key agronomic traits including yield and maturity. Here, we have comparatively reviewed seminal research efforts in previously used antisense approaches and currently applied breakthrough RNAi studies in cotton, analyzing developed RNAi methodologies, achievements, limitations, and future needs in functional characterizations of cotton genes. We also highlighted needed efforts in the development of RNAi-based cotton cultivars, and their safety and risk assessment, small and large-scale field trials, and commercialization.

  9. An integrative model for in-silico clinical-genomics discovery science.

    PubMed

    Lussier, Yves A; Sarkar, Indra Nell; Cantor, Michael

    2002-01-01

    Human Genome discovery research has set the pace for Post-Genomic Discovery Research. While post-genomic fields focused at the molecular level are intensively pursued, little effort is being deployed in the later stages of molecular medicine discovery research, such as clinical-genomics. The objective of this study is to demonstrate the relevance and significance of integrating mainstream clinical informatics decision support systems to current bioinformatics genomic discovery science. This paper is a feasibility study of an original model enabling novel "in-silico" clinical-genomic discovery science and that demonstrates its feasibility. This model is designed to mediate queries among clinical and genomic knowledge bases with relevant bioinformatic analytic tools (e.g. gene clustering). Briefly, trait-disease-gene relationships were successfully illustrated using QMR, OMIM, SNOMED-RT, GeneCluster and TreeView. The analyses were visualized as two-dimensional dendrograms of clinical observations clustered around genes. To our knowledge, this is the first study using knowledge bases of clinical decision support systems for genomic discovery. Although this study is a proof of principle, it provides a framework for the development of clinical decision-support-system driven, high-throughput clinical-genomic technologies which could potentially unveil significant high-level functions of genes.

  10. 10 CFR 205.13 - Where to file.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; (3) The pricing of propane, butane and natural gasoline pursuant to part 212 of this chapter and the allocation of butane and natural gasoline pursuant to part 211 of this chapter; (4) The allocation and...

  11. 10 CFR 205.13 - Where to file.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...; (3) The pricing of propane, butane and natural gasoline pursuant to part 212 of this chapter and the allocation of butane and natural gasoline pursuant to part 211 of this chapter; (4) The allocation and...

  12. 32 CFR 1907.26 - Notification of decision and prohibition on adverse action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... made to the Interagency Security Classification Appeals Panel (ISCAP) established pursuant to § 5.4 of... CENTRAL INTELLIGENCE AGENCY CHALLENGES TO CLASSIFICATION OF DOCUMENTS BY AUTHORIZED HOLDERS PURSUANT TO Â...

  13. 32 CFR 1907.26 - Notification of decision and prohibition on adverse action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... made to the Interagency Security Classification Appeals Panel (ISCAP) established pursuant to § 5.4 of... CENTRAL INTELLIGENCE AGENCY CHALLENGES TO CLASSIFICATION OF DOCUMENTS BY AUTHORIZED HOLDERS PURSUANT TO Â...

  14. 12 CFR 23.10 - General rule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Pursuant to 12 U.S.C. 24(Tenth) a national bank may invest in tangible personal property, including... lease entered into pursuant to this subpart net of any nonrecourse debt the bank has incurred to finance...

  15. 12 CFR 23.10 - General rule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Pursuant to 12 U.S.C. 24(Tenth) a national bank may invest in tangible personal property, including... lease entered into pursuant to this subpart net of any nonrecourse debt the bank has incurred to finance...

  16. Service Discovery Oriented Management System Construction Method

    NASA Astrophysics Data System (ADS)

    Li, Huawei; Ren, Ying

    2017-10-01

    In order to solve the problem that there is no uniform method for design service quality management system in large-scale complex service environment, this paper proposes a distributed service-oriented discovery management system construction method. Three measurement functions are proposed to compute nearest neighbor user similarity at different levels. At present in view of the low efficiency of service quality management systems, three solutions are proposed to improve the efficiency of the system. Finally, the key technologies of distributed service quality management system based on service discovery are summarized through the factor addition and subtraction of quantitative experiment.

  17. Unusual flavoenzyme catalysis in marine bacteria

    PubMed Central

    Teufel, Robin; Agarwal, Vinayak; Moore, Bradley S.

    2016-01-01

    Ever since the discovery of the flavin cofactor more than 80 years ago, flavin-dependent enzymes have emerged as ubiquitous and versatile redox catalysts in primary metabolism. Yet, the recent advances in the discovery and characterization of secondary metabolic pathways exposed new roles for flavin-mediated catalysis in the generation of structurally complex natural products. Here, we review a selection of key biosynthetic flavoenzymes from marine bacterial secondary metabolism and illustrate how their functional and mechanistic investigation expanded our view of the cofactor's chemical repertoire and led to the discovery of a previously unknown flavin redox state. PMID:26803009

  18. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.

    PubMed

    Bellen, Hugo J; Tong, Chao; Tsuda, Hiroshi

    2010-07-01

    Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The use of an unparalleled wealth of tools, many of which originated between 1910–1960, has enabled milestone discoveries in nervous system development and function. Such findings have triggered and guided many research efforts in vertebrate neuroscience. After 100 years, fruit flies continue to be the choice model system for many neuroscientists. The combinational use of powerful research tools will ensure that this model organism will continue to lead to key discoveries that will impact vertebrate neuroscience.

  19. Protein Complex Production from the Drug Discovery Standpoint.

    PubMed

    Moarefi, Ismail

    2016-01-01

    Small molecule drug discovery critically depends on the availability of meaningful in vitro assays to guide medicinal chemistry programs that are aimed at optimizing drug potency and selectivity. As it becomes increasingly evident, most disease relevant drug targets do not act as a single protein. In the body, they are instead generally found in complex with protein cofactors that are highly relevant for their correct function and regulation. This review highlights selected examples of the increasing trend to use biologically relevant protein complexes for rational drug discovery to reduce costly late phase attritions due to lack of efficacy or toxicity.

  20. Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639

    PubMed Central

    2015-01-01

    The discovery of a novel peripherally acting and selective Cav3.2 T-type calcium channel blocker, ABT-639, is described. HTS hits 1 and 2, which have poor metabolic stability, were optimized to obtain 4, which has improved stability and oral bioavailability. Modification of 4 to further improve ADME properties led to the discovery of ABT-639. Following oral administration, ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. PMID:26101566

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