Engineering Light: Quantum Cascade Lasers

ScienceCinema

Claire Gmachl

2017-12-09

Quantum cascade lasers are ideal for environmental sensing and medical diagnostic applications. Gmachl discusses how these lasers work, and their applications, including their use as chemical trace gas sensors. As examples of these applications, she briefly presents results from her field campaign at the Beijing Olympics, and ongoing campaigns in Texas, Maryland, and Ghana.

Sexism.

ERIC Educational Resources Information Center

Chandler, Pamela; Pennington, Vearl

This handbook is intended to assist teachers in removing sex bias and sex-role stereotyping from the classroom. Following some introductory thoughts about sex bias and examples of sex bias and school-based sex-role stereotyping, the handbook briefly discusses Title IX of the Civil Rights Act. The rest of the handbook contains 35 classroom…

The Role of Wireless Computing Technology in the Design of Schools.

ERIC Educational Resources Information Center

Nair, Prakash

2003-01-01

After briefly describing the educational advantages of wireless networks using mobile computers, discusses the technical, operational, financial aspects of wireless local area networks (WLAN). Provides examples of school facilities designed for the use of WLAN. Includes a glossary of WLAN-related terms. (Contains 12 references.)

Computational Fluid Dynamics Program at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Holst, Terry L.

1989-01-01

The Computational Fluid Dynamics (CFD) Program at NASA Ames Research Center is reviewed and discussed. The technical elements of the CFD Program are listed and briefly discussed. These elements include algorithm research, research and pilot code development, scientific visualization, advanced surface representation, volume grid generation, and numerical optimization. Next, the discipline of CFD is briefly discussed and related to other areas of research at NASA Ames including experimental fluid dynamics, computer science research, computational chemistry, and numerical aerodynamic simulation. These areas combine with CFD to form a larger area of research, which might collectively be called computational technology. The ultimate goal of computational technology research at NASA Ames is to increase the physical understanding of the world in which we live, solve problems of national importance, and increase the technical capabilities of the aerospace community. Next, the major programs at NASA Ames that either use CFD technology or perform research in CFD are listed and discussed. Briefly, this list includes turbulent/transition physics and modeling, high-speed real gas flows, interdisciplinary research, turbomachinery demonstration computations, complete aircraft aerodynamics, rotorcraft applications, powered lift flows, high alpha flows, multiple body aerodynamics, and incompressible flow applications. Some of the individual problems actively being worked in each of these areas is listed to help define the breadth or extent of CFD involvement in each of these major programs. State-of-the-art examples of various CFD applications are presented to highlight most of these areas. The main emphasis of this portion of the presentation is on examples which will not otherwise be treated at this conference by the individual presentations. Finally, a list of principal current limitations and expected future directions is given.

Crew coordination concepts: Continental Airlines CRM training

NASA Technical Reports Server (NTRS)

Christian, Darryl; Morgan, Alice

1987-01-01

The outline of the crew coordination concepts at Continental airlines is: (1) Present relevant theory: Contained in a pre-work package and in lecture/discussion form during the work course, (2) Discuss case examples: Contained in the pre-work for study and use during the course; and (3) Simulate practice problems: Introduced during the course as the beginning of an ongoing process. These concepts which are designed to address the problem pilots have in understanding the interaction between situations and their own theories of practice are briefly discussed.

Numerical simulation for horizontal subsurface flow constructed wetlands: A short review including geothermal effects and solution bounding in biodegradation procedures

NASA Astrophysics Data System (ADS)

Liolios, K.; Tsihrintzis, V.; Angelidis, P.; Georgiev, K.; Georgiev, I.

2016-10-01

Current developments on modeling of groundwater flow and contaminant transport and removal in the porous media of Horizontal Subsurface Flow Constructed Wetlands (HSF CWs) are first reviewed in a short way. The two usual environmental engineering approaches, the black-box and the process-based one, are briefly presented. Next, recent research results obtained by using these two approaches are briefly discussed as application examples, where emphasis is given to the evaluation of the optimal design and operation parameters concerning HSF CWs. For the black-box approach, the use of Artificial Neural Networks is discussed for the formulation of models, which predict the removal performance of HSF CWs. A novel mathematical prove is presented, which concerns the dependence of the first-order removal coefficient on the Temperature and the Hydraulic Residence Time. For the process-based approach, an application example is first discussed which concerns procedures to evaluate the optimal range of values for the removal coefficient, dependent on either the Temperature or the Hydraulic Residence Time. This evaluation is based on simulating available experimental results of pilot-scale units operated in Democritus University of Thrace, Xanthi, Greece. Further, in a second example, a novel enlargement of the system of Partial Differential Equations is presented, in order to include geothermal effects. Finally, in a third example, the case of parameters uncertainty concerning biodegradation procedures is considered and the use of upper and a novel approach is presented, which concerns the upper and the lower solution bound for the practical draft design of HSF CWs.

Application of neural nets in structural optimization

NASA Technical Reports Server (NTRS)

Berke, Laszlo; Hajela, Prabhat

1993-01-01

The biological motivation for Artificial Neural Net developments is briefly discussed, and the most popular paradigm, the feedforward supervised learning net with error back propagation training algorithm, is introduced. Possible approaches for utilization in structural optimization is illustrated through simple examples. Other currently ongoing developments for application in structural mechanics are also mentioned.

On Designing and Evaluating Teaching Sequences Taking Geometrical Optics as an Example

ERIC Educational Resources Information Center

Andersson, Bjorn; Bach, Frank

2005-01-01

National assessments and other investigations have drawn attention to the fact that there is considerable room for improvement in science teaching and learning. This article describes, exemplifies, and discusses a research program set up to address this unsatisfactory state of affairs. Briefly, the idea of the program is that researchers in…

Low Speed Rot or/Fuselage Interactional Aerodynamics

NASA Technical Reports Server (NTRS)

Barnwell, Richard W.; Prichard, Devon S.

2003-01-01

This report presents work performed under a Cooperative Research Agreement between Virginia Tech and the NASA Langley Research Center. The work involved development of computational techniques for modeling helicopter rotor/airframe aerodynamic interaction. A brief overview of the problem is presented, the modeling techniques are described, and selected example calculations are briefly discussed.

Teaching Prepositions to Very Young Learners the Case of "On"

ERIC Educational Resources Information Center

Piquer-Píriz, Ana

2006-01-01

The author discusses the benefits of applying cognitive linguistics, L1 acquisition, and neo-Vygotskian (Vygotsky) approaches to the teaching of a second language to young learners, using the example of teaching the preposition "on." The author briefly reviews how prepositions are taught to adult learners and the challenges of teaching…

Teaching for Social Justice in Multicultural Classrooms

ERIC Educational Resources Information Center

Sleeter, Christine

2013-01-01

Drawing on my work in the U.S., I briefly discuss four related hallmarks of teaching for social justice in diverse classrooms, supported by research on their impact on students. They include explicitly recognizing and working with students' culture as a basis for learning, teaching key concepts in the curriculum through content and examples drawn…

STANDARD BIKOL.

ERIC Educational Resources Information Center

EPSTEIN, JON

THE DIALECT OF BIKOL SPOKEN IN NAGA CITY, THE PHILIPPINES, IS DESCRIBED IN THIS SHORT ANALYSIS OF THE MOST BASIC BIKOL STRUCTURAL PATTERNS. IT IS ASSUMED THAT THE READER HAS LINGUISTIC TRAINING OR IS A STUDENT OF BIKOL (SEE ALSO AL 000 502, "BIKOL LESSONS"). PHONOLOGY AND DIALECT DIFFERENCES ARE VERY BRIEFLY DISCUSSED. EXAMPLES ARE GIVEN FOR EACH…

The Benefits, and Fear, of Cookie Technology

ERIC Educational Resources Information Center

Goldsborough, Reid

2004-01-01

"Cookies" are tiny Web browser helpers and are an example of how the useful can get tossed in with the dangerous through the near hysteria brought about by the real threats of computer viruses, hacking, spyware, spam and phishing. This article briefly discusses antispyware legislation by Congress and the pros and cons of past and future…

Acoustics Division recent accomplishments and research plans

NASA Technical Reports Server (NTRS)

Clark, L. R.; Morgan, H. G.

1986-01-01

The research program currently being implemented by the Acoustics Division of NASA Langley Research Center is described. The scope, focus, and thrusts of the research are discussed and illustrated for each technical area by examples of recent technical accomplishments. Included is a list of publications for the last two calendar years. The organization, staff, and facilities are also briefly described.

Annual Percentage Rate and Annual Effective Rate: Resolving Confusion in Intermediate Accounting Textbooks

ERIC Educational Resources Information Center

Vicknair, David; Wright, Jeffrey

2015-01-01

Evidence of confusion in intermediate accounting textbooks regarding the annual percentage rate (APR) and annual effective rate (AER) is presented. The APR and AER are briefly discussed in the context of a note payable and correct formulas for computing each is provided. Representative examples of the types of confusion that we found is presented…

Laser and gas centrifuge enrichment

NASA Astrophysics Data System (ADS)

Heinonen, Olli

2014-05-01

Principles of uranium isotope enrichment using various laser and gas centrifuge techniques are briefly discussed. Examples on production of high enriched uranium are given. Concerns regarding the possibility of using low end technologies to produce weapons grade uranium are explained. Based on current assessments commercial enrichment services are able to cover the global needs of enriched uranium in the foreseeable future.

Angular integrals in d dimensions

NASA Astrophysics Data System (ADS)

Somogyi, Gábor

2011-08-01

We discuss the evaluation of certain d-dimensional angular integrals which arise in perturbative field theory calculations. We find that the angular integral with n denominators can be computed in terms of a certain special function, the so-called H-function of several variables. We also present several illustrative examples of the general result and briefly consider some applications.

Fiber optic sensors

NASA Technical Reports Server (NTRS)

Hesse, J.; Sohler, W.

1984-01-01

A survey of the developments in the field of fiber optics sensor technology is presented along with a discussion of the advantages of optical measuring instruments as compared with electronic sensors. The two primary types of fiber optics sensors, specifically those with multiwave fibers and those with monowave fibers, are described. Examples of each major sensor type are presented and discussed. Multiwave detectors include external and internal fiber optics sensors. Among the monowave detectors are Mach-Zender interferometers, Michelson interferometers, Sagnac interferometers (optical gyroscopes), waveguide resonators, and polarimeter sensors. Integrated optical sensors and their application in spectroscopy are briefly discussed.

Communication theory of quantum systems. Ph.D. Thesis, 1970

NASA Technical Reports Server (NTRS)

Yuen, H. P. H.

1971-01-01

Communication theory problems incorporating quantum effects for optical-frequency applications are discussed. Under suitable conditions, a unique quantum channel model corresponding to a given classical space-time varying linear random channel is established. A procedure is described by which a proper density-operator representation applicable to any receiver configuration can be constructed directly from the channel output field. Some examples illustrating the application of our methods to the development of optical quantum channel representations are given. Optimizations of communication system performance under different criteria are considered. In particular, certain necessary and sufficient conditions on the optimal detector in M-ary quantum signal detection are derived. Some examples are presented. Parameter estimation and channel capacity are discussed briefly.

Spectroscopy and astronomy: H3+ from the laboratory to the Galactic center.

PubMed

Oka, Takeshi

2011-01-01

Since the serendipitous discovery of the Fraunhofer spectrum in the Sun in 1814 which initiated spectroscopy and astrophysics, spectroscopy developed hand in hand with astronomy. I discuss my own work on the infrared spectrum of H3+ from its discovery in the laboratory in 1980, in interstellar space in 1996, to recent studies in the Galactic center as an example of astronomical spectroscopy. Its spin-off, the spectroscopy of simple molecular ions, is also briefly discussed.

Two if by Sea: America's Maritime Heritage and the Social Studies Teacher.

ERIC Educational Resources Information Center

Heitzmann, Wm. Ray

In the first part of this document, teachers are urged to include United States' maritime history in planning social studies courses, units, and lessons. After a rationale for teaching the study of the sea, ways in which this topic can be used as content are briefly discussed. For example, units can be developed around the ship building industry,…

Design and control considerations for industrial and space manipulators

NASA Technical Reports Server (NTRS)

Whitney, D. E.; Book, W. J.; Lynch, P. M.

1974-01-01

This paper is a progress report summarizing theoretical and practical results concerning integration of design and control aspects of manipulator arms for industrial or space applications. The relationships between task specifications, gross motions, fine motions, actuator type and location, size and strength of structural members, control servos and strategies, and overall design evaluation are briefly discussed, with some technical examples.

Examples of seismic modelling

NASA Astrophysics Data System (ADS)

Pamyatnykh, A. A.

2008-12-01

Findings of a few recent asteroseismic studies of the main sequence pulsating stars, as per- formed in Wojciech Dziembowski’s group in Warsaw and in Michel Breger’s group in Vienna, are briefly presented and discussed. The selected objects are three hybrid pulsators ν Eridani, 12 Lacertae and γ Pegasi, which show both β Cephei and SPB type modes, and the δ Scuti type star 44 Tauri.

Phased Arrays of Ground and Airborne Mobile Terminals for Satellite Communications

NASA Technical Reports Server (NTRS)

Huang, John

1996-01-01

Phased array antenna is beginning to play an important in the arena of mobile/satellite communications. Two examples of mobile terminal phased arrays will be shown. Their technical background, challenges, and cost drivers will be discussed. A possible solution to combat some of the deficiencies of the conventional phased array by exploiting the phased reflectarray technology will be briefly presented.

Large-scale configuration interaction description of the structure of nuclei around 100Sn and 208Pb

NASA Astrophysics Data System (ADS)

Qi, Chong

2016-08-01

In this contribution I would like to discuss briefly the recent developments of the nuclear configuration interaction shell model approach. As examples, we apply the model to calculate the structure and decay properties of low-lying states in neutron-deficient nuclei around 100Sn and 208Pb that are of great experimental and theoretical interests.

Cloud computing basics for librarians.

PubMed

Hoy, Matthew B

2012-01-01

"Cloud computing" is the name for the recent trend of moving software and computing resources to an online, shared-service model. This article briefly defines cloud computing, discusses different models, explores the advantages and disadvantages, and describes some of the ways cloud computing can be used in libraries. Examples of cloud services are included at the end of the article. Copyright © Taylor & Francis Group, LLC

A digital future for the history of psychology?

PubMed

Green, Christopher D

2016-08-01

This article discusses the role that digital approaches to the history of psychology are likely to play in the near future. A tentative hierarchy of digital methods is proposed. A few examples are briefly described: a digital repository, a simple visualization using ready-made online database and tools, and more complex visualizations requiring the assembly of the database and, possibly, the analytic tools by the researcher. The relationship of digital history to the old "New Economic History" (Cliometrics) is considered. The question of whether digital history and traditional history need be at odds or, instead, might complement each other is woven throughout. The rapidly expanding territory of digital humanistic research outside of psychology is briefly discussed. Finally, the challenging current employment trends in history and the humanities more broadly are considered, along with the role that digital skills might play in mitigating those factors for prospective academic workers. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Some past and present challenges of econophysics

NASA Astrophysics Data System (ADS)

Mantegna, R. N.

2016-12-01

We discuss the cultural background that was shared by some of the first econophysicists when they started to work on economic and financial problems with methods and tools of statistical physics. In particular we discuss about the role of stylized facts and statistical physical laws in economics and statistical physics respectively. As an example of the problems and potentials associated with the interaction of different communities of scholars dealing with problems observed in economic and financial systems we briefly discuss the development and the perspectives of the use of tools and concepts of networks in econophysics, economics and finance.

Measuring large scale space perception in literary texts

NASA Astrophysics Data System (ADS)

Rossi, Paolo

2007-07-01

A center and radius of “perception” (in the sense of environmental cognition) can be formally associated with a written text and operationally defined. Simple algorithms for their computation are presented, and indicators for anisotropy in large scale space perception are introduced. The relevance of these notions for the analysis of literary and historical records is briefly discussed and illustrated with an example taken from medieval historiography.

Fluorescing aerosols and clouds: investigations of co-existence

NASA Astrophysics Data System (ADS)

Reichardt, Jens; Leinweber, Ronny; Schwebe, Anne

2018-04-01

RAMSES of the Lindenberg Meteorological Observatory, Germany, is the first multipurpose lidar to routinely measure the fluorescence spectra of atmospheric aerosols. Combined with the other measurement parameters (cloud water content and optical properties, moisture and temperature), this capability allows one to study the co-existence of clouds and fluorescing aerosols for the first time. The fluorescence receiver is briefly described, and measurement examples are presented and discussed.

Construction of a Penrose Diagram for a Spatially Coherent Evaporating Black Hole

NASA Technical Reports Server (NTRS)

Brown, Beth A.; Lindesay, James

2007-01-01

A Penrose diagram is constructed for an example black hole that evaporates at a steady rate as measured by a distant observer, until the mass vanishes, yielding a final state Minkowski space-time. Coordinate dependencies of significant features, such as the horizon and coordinate anomalies, are clearly demonstrated on the diagram. The large-scale causal structure of the space-time is briefly discussed.

Polymers application in proton exchange membranes for fuel cells (PEMFCs)

NASA Astrophysics Data System (ADS)

Walkowiak-Kulikowska, Justyna; Wolska, Joanna; Koroniak, Henryk

2017-07-01

This review presents the most important research on alternative polymer membranes with ionic groups attached, provides examples of materials with a well-defined chemical structure that are described in the literature. Furthermore, it elaborates on the synthetic methods used for preparing PEMs, the current status of fuel cell technology and its application. It also briefly discusses the development of the PEMFC market.

Green chemistry: development trajectory

NASA Astrophysics Data System (ADS)

Moiseev, I. I.

2013-07-01

Examples of applications of green chemistry methods in heavy organic synthesis are analyzed. Compounds, which can be produced by the processing of the biomass, and the criteria for the selection of the most promising products are summarized. The current status of the ethanol production and processing is considered. The possibilities of the use of high fatty acid triglycerides, glycerol, succinic acid, and isoprene are briefly discussed. The bibliography includes 67 references.

Recent Research with the Detector for Advanced Neutron Capture Experiments (dance) at the LOS Alamos Neutron Science Center

NASA Astrophysics Data System (ADS)

Ullmann, J. L.

2014-09-01

The DANCE detector at Los Alamos is a 160 element, nearly 4π BaF2 detector array designed to make measurements of neutron capture on rare or radioactive nuclides. It has also been used to make measurements of gamma-ray multiplicity following capture and gamma-ray output from fission. Several examples of measurements are briefly discussed.

Multi-Core Processors: An Enabling Technology for Embedded Distributed Model-Based Control (Postprint)

DTIC Science & Technology

2008-07-01

generation of process partitioning, a thread pipelining becomes possible. In this paper we briefly summarize the requirements and trends for FADEC based... FADEC environment, presenting a hypothetical realization of an example application. Finally we discuss the application of Time-Triggered...based control applications of the future. 15. SUBJECT TERMS Gas turbine, FADEC , Multi-core processing technology, disturbed based control

Geochronological and lead-isotope evidences for rapid crust formation in middle-proterozoic time: The Labrador example

NASA Technical Reports Server (NTRS)

Schaerer, Urs

1988-01-01

Extensive U-Pb geochronological studies in the Grenville and Makkovik provinces have shown that eastern Labrador is underlain by two distinct crustal blocks. In order to substantiate the juvenile character of the middle-Proterozoic crustal block, the isotopic compositon of lead in leached k-feldspars from the same rocks were analyzed. The results of the analysis are briefly discussed.

NASA aviation safety reporting system

NASA Technical Reports Server (NTRS)

1977-01-01

During the third quarter of operation of the Aviation Safety Reporting System (ASRS), 1429 reports concerning aviation safety were received from pilots, air traffic controllers, and others in the national aviation system. Details of the administration and results of the program are discussed. The design and construction of the ASRS data base are briefly presented. Altitude deviations and potential aircraft conflicts associated with misunderstood clearances were studied and the results are discussed. Summary data regarding alert bulletins, examples of alert bulletins and responses to them, and a sample of deidentified ASRS reports are provided.

On the general constraints in single qubit quantum process tomography

DOE PAGES

Bhandari, Ramesh; Peters, Nicholas A.

2016-05-18

In this study, we briefly review single-qubit quantum process tomography for trace-preserving and nontrace-preserving processes, and derive explicit forms of the general constraints for fitting experimental data. These forms provide additional insight into the structure of the process matrix. We illustrate this with several examples, including a discussion of qubit leakage error models and the intuition which can be gained from their process matrices.

Gen IV Materials Handbook Beta Release for Structural and Functional Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ren, Weiju; Luttrell, Claire

2006-09-12

Development of the Gen IV Materials Handbook is briefly summarized up to date. Current status of the Handbook website construction is described. The developed Handbook components and access control of the beta version are discussed for the present evaluation release. Detailed instructions and examples are given to provide guidance for evaluators to browse the constructed parts and use all the currently developed functionalities of the Handbook in evaluation.

A deformation of Sasakian structure in the presence of torsion and supergravity solutions

NASA Astrophysics Data System (ADS)

Houri, Tsuyoshi; Takeuchi, Hiroshi; Yasui, Yukinori

2013-07-01

A deformation of Sasakian structure in the presence of totally skew-symmetric torsion is discussed on odd-dimensional manifolds whose metric cones are Kähler with torsion. It is shown that such a geometry inherits similar properties to those of Sasakian geometry. As their example, we present an explicit expression of local metrics. It is also demonstrated that our example of the metrics admits the existence of hidden symmetry described by non-trivial odd-rank generalized closed conformal Killing-Yano tensors. Furthermore, using these metrics as an ansatz, we construct exact solutions in five-dimensional minimal gauged/ungauged supergravity and 11-dimensional supergravity. Finally, the global structures of the solutions are discussed. We obtain regular metrics on compact manifolds in five dimensions, which give natural generalizations of Sasaki-Einstein manifolds Yp, q and La, b, c. We also briefly discuss regular metrics on non-compact manifolds in 11 dimensions.

Aircraft parameter estimation

NASA Technical Reports Server (NTRS)

Iliff, Kenneth W.

1987-01-01

The aircraft parameter estimation problem is used to illustrate the utility of parameter estimation, which applies to many engineering and scientific fields. Maximum likelihood estimation has been used to extract stability and control derivatives from flight data for many years. This paper presents some of the basic concepts of aircraft parameter estimation and briefly surveys the literature in the field. The maximum likelihood estimator is discussed, and the basic concepts of minimization and estimation are examined for a simple simulated aircraft example. The cost functions that are to be minimized during estimation are defined and discussed. Graphic representations of the cost functions are given to illustrate the minimization process. Finally, the basic concepts are generalized, and estimation from flight data is discussed. Some of the major conclusions for the simulated example are also developed for the analysis of flight data from the F-14, highly maneuverable aircraft technology (HiMAT), and space shuttle vehicles.

Wind loading on solar concentrators: Some general considerations

NASA Technical Reports Server (NTRS)

Roschke, E. J.

1984-01-01

A survey was completed to examine the problems and complications arising from wind loading on solar concentrators. Wind loading is site specific and has an important bearing on the design, cost, performance, operation and maintenance, safety, survival, and replacement of solar collecting systems. Emphasis herein is on paraboloidal, two-axis tracking systems. Thermal receiver problems also are discussed. Wind characteristics are discussed from a general point of view. Current methods for determining design wind speed are reviewed. Aerodynamic coefficients are defined and illustrative examples are presented. Wind tunnel testing is discussed, and environmental wind tunnels are reviewed. Recent results on heliostat arrays are reviewed as well. Aeroelasticity in relation to structural design is discussed briefly.

Technical Application of Nuclear Fission

NASA Astrophysics Data System (ADS)

Denschlag, J. O.

The chapter is devoted to the practical application of the fission process, mainly in nuclear reactors. After a historical discussion covering the natural reactors at Oklo and the first attempts to build artificial reactors, the fundamental principles of chain reactions are discussed. In this context chain reactions with fast and thermal neutrons are covered as well as the process of neutron moderation. Criticality concepts (fission factor η, criticality factor k) are discussed as well as reactor kinetics and the role of delayed neutrons. Examples of specific nuclear reactor types are presented briefly: research reactors (TRIGA and ILL High Flux Reactor), and some reactor types used to drive nuclear power stations (pressurized water reactor [PWR], boiling water reactor [BWR], Reaktor Bolshoi Moshchnosti Kanalny [RBMK], fast breeder reactor [FBR]). The new concept of the accelerator-driven systems (ADS) is presented. The principle of fission weapons is outlined. Finally, the nuclear fuel cycle is briefly covered from mining, chemical isolation of the fuel and preparation of the fuel elements to reprocessing the spent fuel and conditioning for deposit in a final repository.

Maximum Likelihood Estimation with Emphasis on Aircraft Flight Data

NASA Technical Reports Server (NTRS)

Iliff, K. W.; Maine, R. E.

1985-01-01

Accurate modeling of flexible space structures is an important field that is currently under investigation. Parameter estimation, using methods such as maximum likelihood, is one of the ways that the model can be improved. The maximum likelihood estimator has been used to extract stability and control derivatives from flight data for many years. Most of the literature on aircraft estimation concentrates on new developments and applications, assuming familiarity with basic estimation concepts. Some of these basic concepts are presented. The maximum likelihood estimator and the aircraft equations of motion that the estimator uses are briefly discussed. The basic concepts of minimization and estimation are examined for a simple computed aircraft example. The cost functions that are to be minimized during estimation are defined and discussed. Graphic representations of the cost functions are given to help illustrate the minimization process. Finally, the basic concepts are generalized, and estimation from flight data is discussed. Specific examples of estimation of structural dynamics are included. Some of the major conclusions for the computed example are also developed for the analysis of flight data.

Maps, books and other metaphors for systems biology.

PubMed

Ouzounis, Christos; Mazière, Pierre

2006-07-01

We briefly review the use of metaphors in science and progressively focus on fields from biology and molecular biology to genomics and bioinformatics. We discuss how metaphors are both a tool for scientific exploration and a medium for public communication of complex subjects, by various short examples. Finally, we propose a metaphor for systems biology that provides an illuminating perspective for the ambitious goals of this field and delimits its current agenda.

Que hay de nuevo acerca de la inmersion? Un Breve Recorrido por sus Fundamentos y por las Investigaciones Actuales (What's New in Immersion? A Brief Overview of Its Bases and Present-Day Research).

ERIC Educational Resources Information Center

Sierra, Josu

This discussion briefly surveys the development of the immersion method of second language teaching, outlining the central program strategies and characteristics using Curtain's and Pesola's descriptions. An overview of recent research focuses on error correction and feedback studies as an example of pedagogical-methodological evolution in this…

HTML5: a new standard for the Web.

PubMed

Hoy, Matthew B

2011-01-01

HTML5 is the newest revision of the HTML standard developed by the World Wide Web Consortium (W3C). This new standard adds several exciting news features and capabilities to HTML. This article will briefly discuss the history of HTML standards, explore what changes are in the new HTML5 standard, and what implications it has for information professionals. A list of HTML5 resources and examples will also be provided.

Virtual volatility

NASA Astrophysics Data System (ADS)

Silva, A. Christian; Prange, Richard E.

2007-03-01

We introduce the concept of virtual volatility. This simple but new measure shows how to quantify the uncertainty in the forecast of the drift component of a random walk. The virtual volatility also is a useful tool in understanding the stochastic process for a given portfolio. In particular, and as an example, we were able to identify mean reversion effect in our portfolio. Finally, we briefly discuss the potential practical effect of the virtual volatility on an investor asset allocation strategy.

Dynamics of local grid manipulations for internal flow problems

NASA Technical Reports Server (NTRS)

Eiseman, Peter R.; Snyder, Aaron; Choo, Yung K.

1991-01-01

The control point method of algebraic grid generation is briefly reviewed. The review proceeds from the general statement of the method in 2-D unencumbered by detailed mathematical formulation. The method is supported by an introspective discussion which provides the basis for confidence in the approach. The more complex 3-D formulation is then presented as a natural generalization. Application of the method is carried out through 2-D examples which demonstrate the technique.

Computerizing Audit Studies

PubMed Central

Lahey, Joanna N.; Beasley, Ryan A.

2014-01-01

This paper briefly discusses the history, benefits, and shortcomings of traditional audit field experiments to study market discrimination. Specifically it identifies template bias and experimenter bias as major concerns in the traditional audit method, and demonstrates through an empirical example that computerization of a resume or correspondence audit can efficiently increase sample size and greatly mitigate these concerns. Finally, it presents a useful meta-tool that future researchers can use to create their own resume audits. PMID:24904189

Nucleic acid probes in diagnostic medicine

NASA Technical Reports Server (NTRS)

Oberry, Phillip A.

1991-01-01

The need for improved diagnostic procedures is outlined and variations in probe technology are briefly reviewed. A discussion of the application of probe technology to the diagnosis of disease in animals and humans is presented. A comparison of probe versus nonprobe diagnostics and isotopic versus nonisotopic probes is made and the current state of sequence amplification is described. The current market status of nucleic acid probes is reviewed with respect to their diagnostic application in human and veterinary medicine. Representative product examples are described and information on probes being developed that offer promise as future products is discussed.

Big data analytics in healthcare: promise and potential.

PubMed

Raghupathi, Wullianallur; Raghupathi, Viju

2014-01-01

To describe the promise and potential of big data analytics in healthcare. The paper describes the nascent field of big data analytics in healthcare, discusses the benefits, outlines an architectural framework and methodology, describes examples reported in the literature, briefly discusses the challenges, and offers conclusions. The paper provides a broad overview of big data analytics for healthcare researchers and practitioners. Big data analytics in healthcare is evolving into a promising field for providing insight from very large data sets and improving outcomes while reducing costs. Its potential is great; however there remain challenges to overcome.

Testing and Evaluation of Passive Radiation Detection Equipment for Homeland Security

DOE PAGES

West, David L.; Wood, Nathan L.; Forrester, Christina D.

2017-12-01

This article is concerned with test and evaluation methods for passive radiation detection equipment used in homeland security applications. The different types of equipment used in these applications are briefly reviewed and then test and evaluation methods discussed. The primary emphasis is on the test and evaluation standards developed by the American National Standards Institute’s N42 committees. Commonalities among the standards are then reviewed as well as examples of unique aspects for specific equipment types. Throughout, sample test configurations and results from testing and evaluation at Oak Ridge National Laboratory are given. The article concludes with a brief discussion ofmore » typical tests and evaluations not covered by the N42 standards and some examples of test and evaluation that involve the end users of the equipment.« less

Testing and Evaluation of Passive Radiation Detection Equipment for Homeland Security

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, David L.; Wood, Nathan L.; Forrester, Christina D.

This article is concerned with test and evaluation methods for passive radiation detection equipment used in homeland security applications. The different types of equipment used in these applications are briefly reviewed and then test and evaluation methods discussed. The primary emphasis is on the test and evaluation standards developed by the American National Standards Institute’s N42 committees. Commonalities among the standards are then reviewed as well as examples of unique aspects for specific equipment types. Throughout, sample test configurations and results from testing and evaluation at Oak Ridge National Laboratory are given. The article concludes with a brief discussion ofmore » typical tests and evaluations not covered by the N42 standards and some examples of test and evaluation that involve the end users of the equipment.« less

Influence of a detailed model of man on proton depth/dose calculation

NASA Technical Reports Server (NTRS)

Kase, P. G.

1972-01-01

The development of a detailed radiation shielding model of man is discussed. This model will be used to plan for manned space missions in which sensitive human tissues may be subjected to excessive radiation. The model has two configurations: standing and seated. More than 2500 individual elements were used to depict the external conformation, skeleton, and principal organs. The model is briefly described and several examples of its application to mission planning are given.

Data for NASA's AVSSE 2 experiment: 25 mb sounding data and synoptic charts

NASA Technical Reports Server (NTRS)

Fucik, N. F.; Turner, R. E.

1976-01-01

The AVSSE II experiment is described and tabulated rawinsonde data at 25 mb intervals from the surface to 25 mb for the 23 stations participating in the experiment are presented. Soundings were taken between 1,200 GMT, May 6, and 1,200 GMT, May 7, 1975. The methods of data processing and accuracy are briefly discussed. Synoptic charts prepared from the data are presented, as well as an example of contact data.

From the Law of Large Numbers to Large Deviation Theory in Statistical Physics: An Introduction

NASA Astrophysics Data System (ADS)

Cecconi, Fabio; Cencini, Massimo; Puglisi, Andrea; Vergni, Davide; Vulpiani, Angelo

This contribution aims at introducing the topics of this book. We start with a brief historical excursion on the developments from the law of large numbers to the central limit theorem and large deviations theory. The same topics are then presented using the language of probability theory. Finally, some applications of large deviations theory in physics are briefly discussed through examples taken from statistical mechanics, dynamical and disordered systems.

[Plant genetic engineering in Monsanto company: from the first laboratory experiments to worldwide practical use].

PubMed

Konov, A L; Velchev, M; Parcel, D

2005-01-01

The history of modern biotechnology of agricultural plants is briefly considered in the article. Methods of genetic transformation and regeneration of transgenic plants as well as the mechanisms of resistance of genetically modified plants to herbicides and pests are discussed. By the example of genetically modified varieties and hybrids there are shown the ways of solving the problem of weeds and pests. The questions of biosafety legislation in different countries are considered.

Laboratories new to the ICRM.

PubMed

Karam, Lisa; Anagnostakis, Marios J; Gudelis, Arunas; Marsoem, Pujadi; Mauring, Alexander; Wurdiyanto, Gatot; Yücel, Ülkü

2012-09-01

The Scientific Committee of the ICRM decided, for the 2011 Conference, to present laboratories that are at a key developmental stage in establishing, expanding or applying radionuclide metrology capabilities. The expansion of radionuclide metrology capabilities is crucial to meet evolving and emerging needs in health care, environmental monitoring, and nuclear energy. Five laboratories (from Greece, Lithuania, Indonesia, Norway and Turkey) agreed to participate. Each laboratory is briefly introduced, and examples of their capabilities and standardization activities are discussed. Published by Elsevier Ltd.

Aircraft Laminar Flow Control

NASA Technical Reports Server (NTRS)

Joslin, Ronald D.

1998-01-01

Aircraft laminar flow control (LFC) from the 1930's through the 1990's is reviewed and the current status of the technology is assessed. Examples are provided to demonstrate the benefits of LFC for subsonic and supersonic aircraft. Early studies related to the laminar boundary-layer flow physics, manufacturing tolerances for laminar flow, and insect-contamination avoidance are discussed. LFC concept studies in wind-tunnel and flight experiments are the major focus of the paper. LFC design tools are briefly outlined for completeness.

Data for NASA's AVE 4 experiment: 25 mb sounding data and synoptic charts

NASA Technical Reports Server (NTRS)

Fucik, N. F.; Turner, R. E.

1976-01-01

The AVE IV Experiment is described and tabulated rawinsonde data at 25 mb intervals from the surface to 25 mb for the 42 stations participating in the experiment are presented. Soundings were taken between 0000 GMT, April 24, and 1,200 GMT, April 25, 1975. The methods of data processing and accuracy are briefly discussed. Synoptic charts prepared from the data are presented, as well as an example of contact data.

REVIEWS OF TOPICAL PROBLEMS: Population synthesis in astrophysics

NASA Astrophysics Data System (ADS)

Popov, S. B.; Prokhorov, M. E.

2007-11-01

Population synthesis is a method for numerical simulation of the population of objects with a complex evolution. This method is widely used in astrophysics. We consider its main applications to studying astronomical objects. Examples of modeling evolution are given for populations of close binaries and isolated neutron stars. The application of the method to studying active galactic nuclei and the integral spectral characteristics of galaxies is briefly discussed. An extensive bibliography on all the topics covered is provided.

The Top Quark, QCD, And New Physics.

DOE R&D Accomplishments Database

Dawson, S.

2002-06-01

The role of the top quark in completing the Standard Model quark sector is reviewed, along with a discussion of production, decay, and theoretical restrictions on the top quark properties. Particular attention is paid to the top quark as a laboratory for perturbative QCD. As examples of the relevance of QCD corrections in the top quark sector, the calculation of e{sup+}e{sup -}+ t{bar t} at next-to-leading-order QCD using the phase space slicing algorithm and the implications of a precision measurement of the top quark mass are discussed in detail. The associated production of a t{bar t} pair and a Higgs boson in either e{sup+}e{sup -} or hadronic collisions is presented at next-to-leading-order QCD and its importance for a measurement of the top quark Yulrawa coupling emphasized. Implications of the heavy top quark mass for model builders are briefly examined, with the minimal supersymmetric Standard Model and topcolor discussed as specific examples.

Analysis of Local Structure, Chemistry and Bonding by Electron Energy Loss Spectroscopy

NASA Astrophysics Data System (ADS)

Mayer, Joachim

In the present chapter, the reader will first be introduced briefly to the basic principles of analytical transmission electron microscopy (ATEM) with special emphasis on electron energy-loss spectroscopy (EELS) and energy-filtering TEM. The quantification of spectra to obtain chemical information and the origin and interpretation of near-edge fine structures in EELS (ELNES) are discussed. Special attention will be given to the characterization of internal interfaces and the literature in this area will be reviewed. Selected examples of the application of ATEM in the investigation of internal interfaces will be given. These examples include both EELS in the energy-filtering TEM and in the scanning transmission electron microscope (STEM).

Photography applications

USGS Publications Warehouse

Cochran, Susan A.; Goodman, James A.; Purkis, Samuel J.; Phinn, Stuart R.

2013-01-01

Photographic imaging is the oldest form of remote sensing used in coral reef studies. This chapter briefly explores the history of photography from the 1850s to the present, and delves into its application for coral reef research. The investigation focuses on both photographs collected from low-altitude fixed-wing and rotary aircraft, and those collected from space by astronauts. Different types of classification and analysis techniques are discussed, and several case studies are presented as examples of the broad use of photographs as a tool in coral reef research.

Natural Diels-Alderases: Elusive and Irresistable

PubMed Central

Klas, Kimberly; Tsukamoto, Sachiko; Sherman, David H.; Williams, Robert M.

2016-01-01

Eight examples of biosynthetic pathways wherein a natural enzyme has been identified and claimed to function as a catalyst for the [4+2] cycloaddition reaction, namely, Diels-Alderases, are briefly reviewed. These are discussed in the context of the mechanistic challenges associated with the technical difficulty of proving that the net formal [4+2] cycloaddition under study, indeed proceeds through a synchronous, mechanism and that the putative biosynthetic enzyme deploys the pericyclic transition state required for a Diels-Alder cycloaddition reaction. PMID:26495876

Reasoning methods in medical consultation systems: artificial intelligence approaches.

PubMed

Shortliffe, E H

1984-01-01

It has been argued that the problem of medical diagnosis is fundamentally ill-structured, particularly during the early stages when the number of possible explanations for presenting complaints can be immense. This paper discusses the process of clinical hypothesis evocation, contrasts it with the structured decision making approaches used in traditional computer-based diagnostic systems, and briefly surveys the more open-ended reasoning methods that have been used in medical artificial intelligence (AI) programs. The additional complexity introduced when an advice system is designed to suggest management instead of (or in addition to) diagnosis is also emphasized. Example systems are discussed to illustrate the key concepts.

Genetic Dissection of Learning and Memory in Mice

PubMed Central

Mineur, Yann S.; Crusio, Wim E.; Sluyter, Frans

2004-01-01

In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome searches. Next, we briefly review more recently developed techniques, such as microarrays and RNA interference. In addition, we focus on gene-environment interactions and endophenotypes. All sections are illustrated with examples from the learning and memory field, including a table summarizing the latest information about genes that have been shown to have effects on learning and memory. PMID:15656270

Materials Research Conducted Aboard the International Space Station: Facilities Overview, Operational Procedures, and Experimental Outcomes

NASA Technical Reports Server (NTRS)

Grugel, Richard N.; Luz, Paul; Smith, Guy; Spivey, Reggie; Jeter, Linda; Gillies, Donald; Hua, Fay; Anikumar, A. V.

2007-01-01

The Microgravity Science Glovebox (MSG) and Maintenance Work Area (MWA) are facilities aboard the International Space Station (ISS) that were used to successfully conduct experiments in support of, respectively, the Pore Formation and Mobility Investigation (PFMI) and the In-Space Soldering Investigation (ISSI). The capabilities of these facilities are briefly discussed and then demonstrated by presenting "real-time" and subsequently down-linked video-taped examples from the abovementioned experiments. Data interpretation, ISS telescience, some lessons learned, and the need of such facilities for conducting work in support of understanding materials behavior, particularly fluid processing and transport scenarios, in low-gravity environments is discussed.

Materials Research Conducted Aboard the International Space Station: Facilities Overview, Operational Procedures, and Experimental Outcomes

NASA Technical Reports Server (NTRS)

Grugel, R. N.; Luz, P.; Smith, G. A.; Spivey, R.; Jeter, L.; Gillies, D. C.; Hua, F.; Anilkumar, A. V.

2006-01-01

The Microgravity Science Glovebox (MSG) and Maintenance Work Area (MWA) are facilities aboard the International Space Station (ISS) that were used to successfully conduct experiments in support of, respectively, the Pore Formation and Mobility Investigation (PFMI) and the In-Space Soldering Investigation (ISSI). The capabilities of these facilities are briefly discussed and then demonstrated by presenting real-time and subsequently down-linked video-taped examples from the abovementioned experiments. Data interpretation, ISS telescience, some lessons learned, and the need of such facilities for conducting work in support of understanding materials behavior, particularly fluid processing and transport scenarios, in low-gravity environments is discussed.

Thyroid cell lines in research on goitrogenesis.

PubMed

Gerber, H; Peter, H J; Asmis, L; Studer, H

1991-12-01

Thyroid cell lines have contributed a lot to the understanding of goitrogenesis. The cell lines mostly used in thyroid research are briefly discussed, namely the rat thyroid cell lines FRTL and FRTL-5, the porcine thyroid cell lines PORTHOS and ARTHOS, The sheep thyroid cell lines OVNIS 5H and 6H, the cat thyroid cell lines PETCAT 1 to 4 and ROMCAT, and the human thyroid cell lines FTC-133 and HTh 74. Chinese hamster ovary (CHO) cells and COS-7 cells, stably transfected with TSH receptor cDNA and expressing a functional TSH receptor, are discussed as examples for non-thyroidal cells, transfected with thyroid genes.

Lithium alloy negative electrodes

NASA Astrophysics Data System (ADS)

Huggins, Robert A.

The 1996 announcement by Fuji Photo Film of the development of lithium batteries containing convertible metal oxides has caused a great deal of renewed interest in lithium alloys as alternative materials for use in the negative electrode of rechargeable lithium cells. The earlier work on lithium alloys, both at elevated and ambient temperatures is briefly reviewed. Basic principles relating thermodynamics, phase diagrams and electrochemical properties under near-equilibrium conditions are discussed, with the Li-Sn system as an example. Second-phase nucleation, and its hindrance under dynamic conditions plays an important role in determining deviations from equilibrium behavior. Two general types of composite microstructure electrodes, those with a mixed-conducting matrix, and those with a solid electrolyte matrix, are discussed. The Li-Sn-Si system at elevated temperatures, and the Li-Sn-Cd at ambient temperatures are shown to be examples of mixed-conducting matrix microstructures. The convertible oxides are an example of the solid electrolyte matrix type. Although the reversible capacity can be very large in this case, the first cycle irreversible capacity required to convert the oxides to alloys may be a significant handicap.

A Polarization-Diversity Simultaneous-Lobing Angle-Tracking Receiver

NASA Technical Reports Server (NTRS)

Renhult, W. B.

1961-01-01

This report describes a simultaneous-lobing angle-tracking receiver operating in the 225-260 milli-cycle-per-second telemetry band and employing polarization diversity. Its operation is considered primarily in the context of the Mercury range and tracking of the Mercury capsule. Several methods of providing diversity are briefly considered, and a number of ways of implementing the phase shifts required at one polarization for coherent signal addition are discussed. A prototype receiver is briefly described although circuitry which may be somewhat novel is covered in greater detail. No attempt has been made to include all of the sophistication one might expect in a receiver of this type; circuits have been simplified in some areas where, for example, a manual control can replace an automatic function and reduce complexity. Some conclusions are drawn as to how this receiver might perform in the Mercury environment.

The Vaccination Model in Psychoneuroimmunology Research: A Review.

PubMed

Whittaker, Anna C

2018-01-01

This chapter explores the reasoning behind using the vaccination model to examine the influence of psychosocial factors on immunity. It then briefly discusses the mechanics of the vaccination response and the protocols used in psychoneuroimmunology vaccine research, before giving examples from the research literature of the studies examining relationships such as the association between stress and vaccination response. It also explores the ways the vaccination model can be used to answer key questions in psychoneuroimmunology, such as the following: "Does it matter when stressful life events occur relative to when the vaccine is received?" "What are the effects of prior exposure to the antigen?" "Do other psychosocial factors influence vaccine response besides stress?" Finally, it briefly considers the mechanisms underlying psychosocial factors and vaccination response associations and the future research needed to understand these better, and indeed to use current and future knowledge to improve and enhance vaccine responses in key at-risk populations.

EARLY EVALUATION OF NEW HEALTH TECHNOLOGIES: THE CASE FOR PREMARKET STUDIES THAT HARMONIZE REGULATORY AND COVERAGE PERSPECTIVES.

PubMed

Levin, Leslie

2015-01-01

With an increasing awareness that active engagement between policy decision makers, HTA agencies, regulators and payers with industry in the premarket space is needed, a disruptive comprehensive approach is described which moves the evidentiary process exclusively into this space. Single harmonized studies pre-market to address regulatory and coverage needs and expectations are more likely to be efficient and less costly and position evidence to drive rather than test innovation. An example of such a process through the MaRS EXCITE program in Ontario, Canada, now undergoing proof of concept, is briefly discussed. Other examples of dialogue between decision makers and industry pre-market are provided though these are less robust than a comprehensive evidentiary approach.

Optical Design And Analysis Of Carbon Dioxide Laser Fusion Systems Using Interferometry And Fast Fourier Transform Techniques

NASA Astrophysics Data System (ADS)

Viswanathan, V. K.

1980-11-01

The optical design and analysis of the LASL carbon dioxide laser fusion systems required the use of techniques that are quite different from the currently used method in conventional optical design problems. The necessity for this is explored and the method that has been successfully used at Los Alamos to understand these systems is discussed with examples. This method involves characterization of the various optical components in their mounts by a Zernike polynomial set and using fast Fourier transform techniques to propagate the beam, taking diffraction and other nonlinear effects that occur in these types of systems into account. The various programs used for analysis are briefly discussed.

A relational data-knowledge base system and its potential in developing a distributed data-knowledge system

NASA Technical Reports Server (NTRS)

Rahimian, Eric N.; Graves, Sara J.

1988-01-01

A new approach used in constructing a rational data knowledge base system is described. The relational database is well suited for distribution due to its property of allowing data fragmentation and fragmentation transparency. An example is formulated of a simple relational data knowledge base which may be generalized for use in developing a relational distributed data knowledge base system. The efficiency and ease of application of such a data knowledge base management system is briefly discussed. Also discussed are the potentials of the developed model for sharing the data knowledge base as well as the possible areas of difficulty in implementing the relational data knowledge base management system.

Organic Chemistry: From the Interstellar Medium to the Solar System

NASA Technical Reports Server (NTRS)

Sandford, Scott; Witteborn, Fred C. (Technical Monitor)

1997-01-01

This talk will review the various types of organic materials observed in different environments in the interstellar medium, discuss the processes by which these materials may have formed and been modified, and present the evidence supporting the contention that at least a fraction of this material survived incorporation, substantially unaltered, into our Solar System during its formation. The nature of this organic material is of direct interest to issues associated with the origin of life, both because this material represents a large fraction of the Solar System inventory of the biogenically-important elements, and because many of the compounds in this inventory have biogenic implications. Several specific examples of such molecules will be briefly discussed.

A model-based investigation of manipulator characteristics and pilot/vehicle performance

NASA Technical Reports Server (NTRS)

Hess, R. A.

1983-01-01

Hess (1978, 1981) has introduced and discussed a structural model of the human pilot in which proprioceptive feedback plays a fundamental role in determining pilot equalization characteristics. It is pointed out that, on account of the feedback structure, this model may provide more insight into the effects of certain manipulator characteristics upon pilot equalization than would other modeling approaches. The model is briefly discussed, and an outline is presented concerning some of the implications of the model structure regarding the manipulator characteristics. Attention is given to some specific empirical examples of manipulator effects involving glide slope tracking in STOL aircraft, taking into account an employment of the model as a theoretical framework.

Oil-Free Shaft Support System Rotordynamics: Past, Present, and Future Challenges and Opportunities

NASA Technical Reports Server (NTRS)

DellaCorte, Christopher

2011-01-01

Recent breakthroughs in Oil-Free technologies have enabled new high-speed rotor systems and turbomachinery. Such technologies can include compliant-surface gas bearings, magnetic bearings, and advanced solid lubricants and tribo-materials. This presentation briefly reviews critical technology developments and the current state-of-the-art, emerging Oil-Free rotor systems and discusses obstacles preventing more widespread use. Key examples of "best practices" for deploying Oil-Free technologies will be presented and remaining major technical questions surrounding Oil-Free technologies will be brought forward.

Transonic Flow Past Cone Cylinders

NASA Technical Reports Server (NTRS)

Solomon, George E

1955-01-01

Experimental results are presented for transonic flow post cone-cylinder, axially symmetric bodies. The drag coefficient and surface Mach number are studied as the free-stream Mach number is varied and, wherever possible, the experimental results are compared with theoretical predictions. Interferometric results for several typical flow configurations are shown and an example of shock-free supersonic-to-subsonic compression is experimentally demonstrated. The theoretical problem of transonic flow past finite cones is discussed briefly and an approximate solution of the axially symmetric transonic equations, valid for a semi-infinite cone, is presented.

Vortices and the related principles of hydrodynamics

NASA Technical Reports Server (NTRS)

Betz, A

1921-01-01

Here, conceptions concerning vortices are illustrated by the simplest possible examples. Mathematical formulas and similar means of presentation, which, for the most part, do not help the understanding of persons not versed therein, have been avoided as much as possible. Instead, the author has endeavored to demonstrate the phenomena by means of simple geometrical and mechanical illustrations. For the sake of clarity, the author chiefly considers currents in one plane only, a situation that can be readily represented by diagrams. Some of the peculiarities of vortices in three dimensional flow are briefly discussed.

[Phineas Gage, 'Tan' and the importance of case reports].

PubMed

Rosselli, D

The original descriptions of the frontal lobe injury of Phineas Gage (1848) and the slowly growing tumor of 'Tan', Broca's famous patient (1861), are examples of how a simple case report can teach important lessons, some of them still discussed a century and a half later. In this article, the original sources of both of these seminal cases, in Boston and Paris, have been reviewed and are briefly summarized. The lessons learned from them in the effort to localize brain functions are explained and set in the context of modern evidence-based medicine.

Protection of Northern Chile as an ICOMOS/IAU ``Window to the Universe''

NASA Astrophysics Data System (ADS)

Smith, Malcolm G.

2015-03-01

Over the last two decades, La Serena's population has increased by about 70 percent. A site description of the AURA Observatory in Chile as a ``Window to the Universe`` is now available on the recently-launched UNESCO-IAU Astronomical Heritage Web Portal, www.astronomicalheritage.net This can serve as an example of possible material for the Chilean authorities, should they wish to propose the dark skies over much of northern Chile for protection as a World Scientific Heritage site. Some of the steps involved are discussed briefly here.

Measuring star formation rates in blue galaxies

NASA Technical Reports Server (NTRS)

Gallagher, John S., III; Hunter, Deidre A.

1987-01-01

The problems associated with measurements of star formation rates in galaxies are briefly reviewed, and specific models are presented for determinations of current star formation rates from H alpha and Far Infrared (FIR) luminosities. The models are applied to a sample of optically blue irregular galaxies, and the results are discussed in terms of star forming histories. It appears likely that typical irregular galaxies are forming stars at nearly constant rates, although a few examples of systems with enhanced star forming activity are found among HII regions and luminous irregular galaxies.

Community access to health information in Ireland.

PubMed

Macdougall, J

1999-06-01

This paper is based on a research project conducted on consumer health information (CHI) in the Republic of Ireland, the results of which were published in a report entitled Well Read: Developing Consumer Health Information in Ireland. The paper describes the research methodology and the Irish experience in relation to CHI followed by a discussion of access problems, illustrated with examples from the special needs and primary care sectors. The role of information providers in relation to primary healthcare and libraries is examined briefly, and finally the main research conclusions and recommendations are highlighted.

A Tool for Measuring NASA's Aeronautics Research Progress Toward Planned Strategic Community Outcomes

NASA Technical Reports Server (NTRS)

Tahmasebi, Farhad; Pearce, Robert

2016-01-01

Description of a tool for portfolio analysis of NASA's Aeronautics research progress toward planned community strategic Outcomes is presented. For efficiency and speed, the tool takes advantage of a function developed in Excels Visual Basic for Applications. The strategic planning process for determining the community Outcomes is also briefly discussed. Stakeholder buy-in, partnership performance, progress of supporting Technical Challenges, and enablement forecast are used as the criteria for evaluating progress toward Outcomes. A few illustrative examples of using the tool are also presented.

Introduction to nanotechnology: a short course for high school students

NASA Astrophysics Data System (ADS)

Markin, Alexey V.

2016-04-01

This report devoted to presenting results of development and implementation of a short course (4 hours) entitled "Introduction to Nanotechnology" that was specially designed for familiarizing high school students with nanomaterials and nanotechnology. The course contains introduction to nanotechnology, essential definitions, short overview of history, descriptions for various examples of nanomaterials and their classifications, performing demonstration experiments. All these parts of the course are briefly analyzed from pedagogical effectiveness point of view. Finally, results of course testing, problems and perspectives of nano-oriented education at high school are also discussed shortly.

SIG: a general-purpose signal processing program. User's manual. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lager, D.; Azevedo, S.

1985-05-09

SIG is a general-purpose signal processing, analysis, and display program. Its main purpose is to perform manipulations on time-domain and frequenccy-domain signals. The manual contains a complete description of the SIG program from the user's stand-point. A brief exercise in using SIG is shown. Complete descriptions are given of each command in the SIG core. General information about the SIG structure, command processor, and graphics options are provided. An example usage of SIG for solving a problem is developed, and error message formats are briefly discussed. (LEW)

The "Internet of Things": What It Is and What It Means for Libraries.

PubMed

Hoy, Matthew B

2015-01-01

The "Internet of Things" is a popular buzzword but a poorly understood concept. In short, it refers to everyday objects that can sense the environment around them and communicate that data to other objects and services via the Internet. This column will briefly explain what the Internet of Things is and how it might be useful for libraries. It will also discuss some of the problems with and objections to this technology. A list of currently available Internet of Things examples is also included.

The Impact of Corrosion on Society

NASA Astrophysics Data System (ADS)

Hansson, C. M.

2011-10-01

Almost all metals and alloys are unstable in the Earth's atmosphere and will always be susceptible to corrosion. The basic principles of corrosion are briefly described in order to explain the observations of corrosion, which render our personal items as well as industrial machinery and public property dysfunctional, aesthetically displeasing, and potentially dangerous. This is followed by a discussion, with case study examples, of three aspects of the impact of corrosion on society: (1) direct effects resulting in injury or death, (2) contamination of the environment, and (3) the financial costs.

Book Catalogs versus Card Catalogs *

PubMed Central

Pizer, Irwin H.

1965-01-01

The development of the library catalog in book form and its abandonment in favor of the card catalog are briefly traced. The advantages and disadvantages of both types of catalogs are enumerated, and several solutions which tried to combine the best features of both are discussed. The present trend back to the book catalog, made possible by recent advances in computer technology, is analyzed, advantages and disadvantages are compared, current examples are illustrated, and finally the computerized catalog is weighed against both the book and card catalog as to main features and practicality. PMID:14271116

DNA fingerprinting in forensics: past, present, future

PubMed Central

2013-01-01

DNA fingerprinting, one of the great discoveries of the late 20th century, has revolutionized forensic investigations. This review briefly recapitulates 30 years of progress in forensic DNA analysis which helps to convict criminals, exonerate the wrongly accused, and identify victims of crime, disasters, and war. Current standard methods based on short tandem repeats (STRs) as well as lineage markers (Y chromosome, mitochondrial DNA) are covered and applications are illustrated by casework examples. Benefits and risks of expanding forensic DNA databases are discussed and we ask what the future holds for forensic DNA fingerprinting. PMID:24245688

Treatment of anorexia nervosa in children and adolescents.

PubMed

Weaver, Laurel; Sit, Lydia; Liebman, Ronald

2012-04-01

In this review, we discuss the treatment of anorexia nervosa (AN) in children and adolescents, highlighting inpatient and outpatient psychiatric treatment. AN is an illness that involves medical and psychological issues; hence, treatment often requires the seamless integration of several medical professionals. It is important that the treatment model be unified and consistent as patients transition from inpatient to outpatient treatment. We briefly describe the therapeutic principles involved in treatment of AN and then give examples of how we employ these principles across treatment settings and with multiple medical professionals.

Acoustoelasticity

NASA Technical Reports Server (NTRS)

Dowell, E. H.

1976-01-01

Internal sound fields are considered. Specifically, the interaction between the (acoustic) sound pressure field and the (elastic) flexible wall of an enclosure is discussed. Such problems frequently arise when the vibrating walls of a transportation vehicle induce a significant internal sound field. Cabin noise in various flight vehicles and the internal sound field in an automobile are representative examples. A mathematical model, simplified solutions, and numerical results and comparisons with representative experimental data are briefly considered. An overall conclusion is that reasonable grounds for optimism exist with respect to available theoretical models and their predictive capability.

Inflationary dynamics with a smooth slow-roll to constant-roll era transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Odintsov, S.D.; Oikonomou, V.K., E-mail: odintsov@ieec.uab.es, E-mail: v.k.oikonomou1979@gmail.com

In this paper we investigate the implications of having a varying second slow-roll index on the canonical scalar field inflationary dynamics. We shall be interested in cases that the second slow-roll can take small values and correspondingly large values, for limiting cases of the function that quantifies the variation of the second slow-roll index. As we demonstrate, this can naturally introduce a smooth transition between slow-roll and constant-roll eras. We discuss the theoretical implications of the mechanism we introduce and we use various illustrative examples in order to better understand the new features that the varying second slow-roll index introduces.more » In the examples we will present, the second slow-roll index has exponential dependence on the scalar field, and in one of these cases, the slow-roll era corresponds to a type of α-attractor inflation. Finally, we briefly discuss how the combination of slow-roll and constant-roll may lead to non-Gaussianities in the primordial perturbations.« less

Applying horizontal gene transfer phenomena to enhance non-viral gene therapy

PubMed Central

Elmer, Jacob J.; Christensen, Matthew D.; Rege, Kaushal

2014-01-01

Horizontal gene transfer (HGT) is widespread amongst prokaryotes, but eukaryotes tend to be far less promiscuous with their genetic information. However, several examples of HGT from pathogens into eukaryotic cells have been discovered and mimicked to improve non-viral gene delivery techniques. For example, several viral proteins and DNA sequences have been used to significantly increase cytoplasmic and nuclear gene delivery. Plant genetic engineering is routinely performed with the pathogenic bacterium Agrobacterium tumefaciens and similar pathogens (e.g. Bartonella henselae) may also be able to transform human cells. Intracellular parasites like Trypanosoma cruzi may also provide new insights into overcoming cellular barriers to gene delivery. Finally, intercellular nucleic acid transfer between host cells will also be briefly discussed. This article will review the unique characteristics of several different viruses and microbes and discuss how their traits have been successfully applied to improve non-viral gene delivery techniques. Consequently, pathogenic traits that originally caused diseases may eventually be used to treat many genetic diseases. PMID:23994344

Continuous Glucose Monitoring: Current Use in Diabetes Management and Possible Future Applications.

PubMed

Vettoretti, Martina; Cappon, Giacomo; Acciaroli, Giada; Facchinetti, Andrea; Sparacino, Giovanni

2018-05-01

The recent announcement of the production of new low-cost continuous glucose monitoring (CGM) sensors, the approval of marketed CGM sensors for making treatment decisions, and new reimbursement criteria have the potential to revolutionize CGM use. After briefly summarizing current CGM applications, we discuss how, in our opinion, these changes are expected to extend CGM utilization beyond diabetes patients, for example, to subjects with prediabetes or even healthy individuals. We also elaborate on how the integration of CGM data with other relevant information, for example, health records and other medical device/wearable sensor data, will contribute to creating a digital data ecosystem that will improve our understanding of the etiology and complications of diabetes and will facilitate the development of data analytics for personalized diabetes management and prevention.

Bayesian data analysis for newcomers.

PubMed

Kruschke, John K; Liddell, Torrin M

2018-02-01

This article explains the foundational concepts of Bayesian data analysis using virtually no mathematical notation. Bayesian ideas already match your intuitions from everyday reasoning and from traditional data analysis. Simple examples of Bayesian data analysis are presented that illustrate how the information delivered by a Bayesian analysis can be directly interpreted. Bayesian approaches to null-value assessment are discussed. The article clarifies misconceptions about Bayesian methods that newcomers might have acquired elsewhere. We discuss prior distributions and explain how they are not a liability but an important asset. We discuss the relation of Bayesian data analysis to Bayesian models of mind, and we briefly discuss what methodological problems Bayesian data analysis is not meant to solve. After you have read this article, you should have a clear sense of how Bayesian data analysis works and the sort of information it delivers, and why that information is so intuitive and useful for drawing conclusions from data.

Pressure Scalings and Influence Region Research

DTIC Science & Technology

2018-01-01

the results are briefly discussed. Additionally, updated experimental results are presented along with discussion of collaborative research efforts...with upstream and downstream influence, where the influence lengths are defined in terms of a-priori quantities (freestream conditions and...governing equations and the result is briefly discussed. Additionally, updated experimental results are presented along with discussion of

Airflow and Particle Transport Through Human Airways: A Systematic Review

NASA Astrophysics Data System (ADS)

Kharat, S. B.; Deoghare, A. B.; Pandey, K. M.

2017-08-01

This paper describes review of the relevant literature about two phase analysis of air and particle flow through human airways. An emphasis of the review is placed on elaborating the steps involved in two phase analysis, which are Geometric modelling methods and Mathematical models. The first two parts describes various approaches that are followed for constructing an Airway model upon which analysis are conducted. Broad two categories of geometric modelling viz. Simplified modelling and Accurate modelling using medical scans are discussed briefly. Ease and limitations of simplified models, then examples of CT based models are discussed. In later part of the review different mathematical models implemented by researchers for analysis are briefed. Mathematical models used for Air and Particle phases are elaborated separately.

Molecular targets of epigenetic regulation and effectors of environmental influences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choudhuri, Supratim, E-mail: Supratim.Choudhuri@fda.hhs.go; Cui Yue; Klaassen, Curtis D., E-mail: cklaasse@kumc.ed

The true understanding of what we currently define as epigenetics evolved over time as our knowledge on DNA methylation and chromatin modifications and their effects on gene expression increased. The current explosion of research on epigenetics and the increasing documentation of the effects of various environmental factors on DNA methylation, chromatin modification, as well as on the expression of small non-coding RNAs (ncRNAs) have expanded the scope of research on the etiology of various diseases including cancer. The current review briefly discusses the molecular mechanisms of epigenetic regulation and expands the discussion with examples on the role of environment, suchmore » as the immediate environment during development, in inducing epigenetic changes and modulating gene expression.« less

Social Entrepreneurship for Obesity Prevention: What Are the Opportunities?

PubMed

Smith, Tosha Woods; Calancie, Larissa; Ammerman, Alice

2015-09-01

In recent years, social entrepreneurship has emerged as a new field to address social and public health challenges. Social entrepreneurship, which harnesses traditional business practices and market forces to address social challenges, may produce solutions that are more cost-effective and sustainable than those produced by governmental and nonprofit sectors. In this paper, we discuss whether and how social entrepreneurship can be harnessed for obesity prevention by defining and briefly reviewing the rise of social entrepreneurship in the USA, outlining the threat that obesity poses to US society and offering some examples of how social ventures are addressing the problem of obesity. Additional untapped opportunities are also discussed and recommendations given for how social entrepreneurship might impact obesity prevention in the future.

NASA's AVE 7 experiment: 25-mb sounding data

NASA Technical Reports Server (NTRS)

Davis, J. G.; Fuelberg, H. E.; Turner, R. E.

1978-01-01

The AVE 7 Experiment is described and tabulated rawinsonde data at 25 mb internals from the surface to 25 mb for the 24 stations participating in the experiment are presented. Soundings were taken between 0000GMT May 2 and 1200 GMT May 3, 1978. The methods of data processing and the accuracy are briefly discussed. Selected synoptic charts prepared from the data are presented as well as an example of contact data. A tabulation of adverse weather events that occured during the AVE 7 period, including freezing temperature, snow, tornadoes, damaging winds, and flooding, is presented.

High-throughput search for caloric materials: the CaloriCool approach

NASA Astrophysics Data System (ADS)

Zarkevich, N. A.; Johnson, D. D.; Pecharsky, V. K.

2018-01-01

The high-throughput search paradigm adopted by the newly established caloric materials consortium—CaloriCool®—with the goal to substantially accelerate discovery and design of novel caloric materials is briefly discussed. We begin with describing material selection criteria based on known properties, which are then followed by heuristic fast estimates, ab initio calculations, all of which has been implemented in a set of automated computational tools and measurements. We also demonstrate how theoretical and computational methods serve as a guide for experimental efforts by considering a representative example from the field of magnetocaloric materials.

Climate Change and Vector Borne Diseases: Getting A Grip on Control

NASA Astrophysics Data System (ADS)

Glass, G. E.; Ellis, H.

2011-12-01

Pathogens that are transmitted by arthropods to humans kill millions of people a year and have long been identified as systems likely affected by climate change. Despite this, there has been a long controversy of how to evaluate the responses of these infectious disease systems to climatic conditions so that meaningful programmatic dcisions can be made. We briefly review the rationale for overall expectations, using them to identify both the temporal and spatial resolution needed for decision making and then discuss progress to date, using the world global malaria eradication program as an example.

Applications of asynoptic space - Time Fourier transform methods to scanning satellite measurements

NASA Technical Reports Server (NTRS)

Lait, Leslie R.; Stanford, John L.

1988-01-01

A method proposed by Salby (1982) for computing the zonal space-time Fourier transform of asynoptically acquired satellite data is discussed. The method and its relationship to other techniques are briefly described, and possible problems in applying it to real data are outlined. Examples of results obtained using this technique are given which demonstrate its sensitivity to small-amplitude signals. A number of waves are found which have previously been observed as well as two not heretofore reported. A possible extension of the method which could increase temporal and longitudinal resolution is described.

The stability issues in problems of mathematical modeling

NASA Astrophysics Data System (ADS)

Mokin, A. Yu.; Savenkova, N. P.; Udovichenko, N. S.

2018-03-01

In the paper it is briefly considered various aspects of stability concepts, which are used in physics, mathematics and numerical methods of solution. The interrelation between these concepts is described, the questions of preliminary stability research before the numerical solution of the problem and the correctness of the mathematical statement of the physical problem are discussed. Examples of concrete mathematical statements of individual physical problems are given: a nonlocal problem for the heat equation, the Korteweg-de Fries equation with boundary conditions at infinity, the sine-Gordon equation, the problem of propagation of femtosecond light pulses in an area with a cubic nonlinearity.

High-throughput search for caloric materials: the CaloriCool approach

DOE PAGES

Zarkevich, Nikolai A.; Johnson, Duane D.; Pecharsky, V. K.

2017-12-13

The high-throughput search paradigm adopted by the newly established caloric materials consortium—CaloriCool ®—with the goal to substantially accelerate discovery and design of novel caloric materials is briefly discussed. Here, we begin with describing material selection criteria based on known properties, which are then followed by heuristic fast estimates, ab initio calculations, all of which has been implemented in a set of automated computational tools and measurements. We also demonstrate how theoretical and computational methods serve as a guide for experimental efforts by considering a representative example from the field of magnetocaloric materials.

Protocols for Molecular Dynamics Simulations of RNA Nanostructures.

PubMed

Kim, Taejin; Kasprzak, Wojciech K; Shapiro, Bruce A

2017-01-01

Molecular dynamics (MD) simulations have been used as one of the main research tools to study a wide range of biological systems and bridge the gap between X-ray crystallography or NMR structures and biological mechanism. In the field of RNA nanostructures, MD simulations have been used to fix steric clashes in computationally designed RNA nanostructures, characterize the dynamics, and investigate the interaction between RNA and other biomolecules such as delivery agents and membranes.In this chapter we present examples of computational protocols for molecular dynamics simulations in explicit and implicit solvent using the Amber Molecular Dynamics Package. We also show examples of post-simulation analysis steps and briefly mention selected tools beyond the Amber package. Limitations of the methods, tools, and protocols are also discussed. Most of the examples are illustrated for a small RNA duplex (helix), but the protocols are applicable to any nucleic acid structure, subject only to the computational speed and memory limitations of the hardware available to the user.

Mixed methods research in mental health nursing.

PubMed

Kettles, A M; Creswell, J W; Zhang, W

2011-08-01

Mixed methods research is becoming more widely used in order to answer research questions and to investigate research problems in mental health and psychiatric nursing. However, two separate literature searches, one in Scotland and one in the USA, revealed that few mental health nursing studies identified mixed methods research in their titles. Many studies used the term 'embedded' but few studies identified in the literature were mixed methods embedded studies. The history, philosophical underpinnings, definition, types of mixed methods research and associated pragmatism are discussed, as well as the need for mixed methods research. Examples of mental health nursing mixed methods research are used to illustrate the different types of mixed methods: convergent parallel, embedded, explanatory and exploratory in their sequential and concurrent combinations. Implementing mixed methods research is also discussed briefly and the problem of identifying mixed methods research in mental and psychiatric nursing are discussed with some possible solutions to the problem proposed. © 2011 Blackwell Publishing.

Adaptation and readaptation medical concerns of a Mars trip

NASA Technical Reports Server (NTRS)

Johnson, Philip C.

1986-01-01

The ability of the human body to adapt to microgravity environments and to later readapt to a gravity environment was examined. Issues specifically relating to the effects of long duration space flight on the adaptation/readaptation process are discussed. The need for better health prediction techniques is stressed in order to be able to better anticipate crew health problems and to perform corrective actions. Several specific examples are discussed of latent diseases which could occur during a long duration space mission, even after having subjected the crew to thorough premission checkups. The need for learning how to prevent or ameliorate such problems as space adaptation syndrome, bone and muscle (and possibly tissue) atrophy, immune system atrophy, and heart arrythmias is also discussed. The implications of the age of the crew, the influence of an onboard low level gravity field, and drugs are briefly addressed as factors in the adaptation/readaptation process.

Study of the Open Loop and Closed Loop Oscillator Techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Imel, George R.; Baker, Benjamin; Riley, Tony

This report presents the progress and completion of a five-year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques.The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this report we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign tomore » measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems.« less

Study of the open loop and closed loop oscillator techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, Benjamin; Riley, Tony; Langbehn, Adam

This paper presents some aspects of a five year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques. The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this paper we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign tomore » measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems. (authors)« less

Ultramicroelectrode voltammetry and scanning electrochemical microscopy in room-temperature ionic liquid electrolytes.

PubMed

Walsh, Darren A; Lovelock, Kevin R J; Licence, Peter

2010-11-01

The high viscosity and unusual properties of room temperature ionic liquids (RTILs) present a number of challenges when performing steady-state voltammetry and scanning electrochemical microscopy in RTILs. These include difficulties in recording steady-state currents at ultramicroelectrode surfaces due to low diffusion coefficients of redox species and problems associated with unequal diffusion coefficients of oxidised and reduced species in RTILs. In this tutorial review, we highlight the recent progress in the use of RTILs as electrolytes for ultramicroelectrode voltammetry and SECM. We describe the basic principles of ultramicroelectrode voltammetry and SECM and, using examples from the recent literature, we discuss the conditions that must be met to perform steady-state voltammetry and SECM measurements in RTILs. Finally, we briefly discuss the electrochemical insights that can be obtained from such measurements.

The potential of cloud point system as a novel two-phase partitioning system for biotransformation.

PubMed

Wang, Zhilong

2007-05-01

Although the extractive biotransformation in two-phase partitioning systems have been studied extensively, such as the water-organic solvent two-phase system, the aqueous two-phase system, the reverse micelle system, and the room temperature ionic liquid, etc., this has not yet resulted in a widespread industrial application. Based on the discussion of the main obstacles, an exploitation of a cloud point system, which has already been applied in a separation field known as a cloud point extraction, as a novel two-phase partitioning system for biotransformation, is reviewed by analysis of some topical examples. At the end of the review, the process control and downstream processing in the application of the novel two-phase partitioning system for biotransformation are also briefly discussed.

Control of root growth and development by reactive oxygen species.

PubMed

Tsukagoshi, Hironaka

2016-02-01

Reactive oxygen species (ROS) are relatively simple molecules that exist within cells growing in aerobic conditions. ROS were originally associated with oxidative stress and seen as highly reactive molecules that are injurious to many cell components. More recently, however, the function of ROS as signal molecules in many plant cellular processes has become more evident. One of the most important functions of ROS is their role as a plant growth regulator. For example, ROS are key molecules in regulating plant root development, and as such, are comparable to plant hormones. In this review, the molecular mechanisms of ROS that are mainly associated with plant root growth are discussed. The molecular links between root growth regulation by ROS and other signals will also be briefly discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

The rolling motion of an eccentrically loaded wheel

NASA Astrophysics Data System (ADS)

Theron, W. F. D.

2000-09-01

This article discusses the rolling motion on a rough plane of a wheel whose center of mass does not coincide with the axis; for example, when a heavy particle is fixed to the rim of a rigid hoop. In cases with large eccentricity, the resulting motion is surprisingly complex, with four phases being identified, namely rolling (without slipping), spinning, skidding, and "hopping," by which is meant that the wheel actually leaves the plane. The main result of this analysis is the identification of the conditions that are required for hopping to occur. A second result is that faster than gravity accelerations occur when the mass of the particle is greater than the mass of the hoop. Massless hoops are briefly discussed as a special case of the general results.

Generalized dynamic engine simulation techniques for the digital computer

NASA Technical Reports Server (NTRS)

Sellers, J.; Teren, F.

1974-01-01

Recently advanced simulation techniques have been developed for the digital computer and used as the basis for development of a generalized dynamic engine simulation computer program, called DYNGEN. This computer program can analyze the steady state and dynamic performance of many kinds of aircraft gas turbine engines. Without changes to the basic program, DYNGEN can analyze one- or two-spool turbofan engines. The user must supply appropriate component performance maps and design-point information. Examples are presented to illustrate the capabilities of DYNGEN in the steady state and dynamic modes of operation. The analytical techniques used in DYNGEN are briefly discussed, and its accuracy is compared with a comparable simulation using the hybrid computer. The impact of DYNGEN and similar all-digital programs on future engine simulation philosophy is also discussed.

Generalized dynamic engine simulation techniques for the digital computer

NASA Technical Reports Server (NTRS)

Sellers, J.; Teren, F.

1974-01-01

Recently advanced simulation techniques have been developed for the digital computer and used as the basis for development of a generalized dynamic engine simulation computer program, called DYNGEN. This computer program can analyze the steady state and dynamic performance of many kinds of aircraft gas turbine engines. Without changes to the basic program DYNGEN can analyze one- or two-spool turbofan engines. The user must supply appropriate component performance maps and design-point information. Examples are presented to illustrate the capabilities of DYNGEN in the steady state and dynamic modes of operation. The analytical techniques used in DYNGEN are briefly discussed, and its accuracy is compared with a comparable simulation using the hybrid computer. The impact of DYNGEN and similar all-digital programs on future engine simulation philosophy is also discussed.

Generalized dynamic engine simulation techniques for the digital computers

NASA Technical Reports Server (NTRS)

Sellers, J.; Teren, F.

1975-01-01

Recently advanced simulation techniques have been developed for the digital computer and used as the basis for development of a generalized dynamic engine simulation computer program, called DYNGEN. This computer program can analyze the steady state and dynamic performance of many kinds of aircraft gas turbine engines. Without changes to the basic program, DYNGEN can analyze one- or two-spool turbofan engines. The user must supply appropriate component performance maps and design point information. Examples are presented to illustrate the capabilities of DYNGEN in the steady state and dynamic modes of operation. The analytical techniques used in DYNGEN are briefly discussed, and its accuracy is compared with a comparable simulation using the hybrid computer. The impact of DYNGEN and similar digital programs on future engine simulation philosophy is also discussed.

Scaling Cross Sections for Ion-atom Impact Ionization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Igor D. Kaganovich; Edward Startsev; Ronald C. Davidson

2003-06-06

The values of ion-atom ionization cross sections are frequently needed for many applications that utilize the propagation of fast ions through matter. When experimental data and theoretical calculations are not available, approximate formulas are frequently used. This paper briefly summarizes the most important theoretical results and approaches to cross section calculations in order to place the discussion in historical perspective and offer a concise introduction to the topic. Based on experimental data and theoretical predictions, a new fit for ionization cross sections is proposed. The range of validity and accuracy of several frequently used approximations (classical trajectory, the Born approximation,more » and so forth) are discussed using, as examples, the ionization cross sections of hydrogen and helium atoms by various fully stripped ions.« less

Which horse do you ride? Trauma from a relational perspective. Discussion of Prince's "The self in pain: the paradox of memory. The paradox of testimony".

PubMed

Thomas, Nina K

2009-12-01

Discussing Dr. Robert Prince's clinical case example, the author presents a relational psychoanalytic perspective on working with the traumatized patient. She considers the presentation of his work with a Holocaust survivor from a relational perspective with particular attention to the dyadic interaction, the intersubjectivity and co-creations of patient and analyst, and finally, addresses the role of the "witness" in psychoanalytic work. The idea of the witness has particular currency in contemporary psychoanalytic thinking. The author briefly examines the dimensions of the "witness" from a relational point of view. Consideration is also given to the necessary distinction between adult onset and childhood onset trauma and the repercussions of each for the analytic couple.

Aging and longevity in the simplest animals and the quest for immortality

PubMed Central

Petralia, Ronald S.; Mattson, Mark P.; Yao, Pamela J.

2014-01-01

Here we review the examples of great longevity and potential immortality in the earliest animal types and contrast and compare these to humans and other higher animals. We start by discussing aging in single-celled organisms such as yeast and ciliates, and the idea of the immortal cell clone. Then we describe how these cell clones could become organized into colonies of different cell types that lead to multicellular animal life. We survey aging and longevity in all of the basal metazoan groups including ctenophores (comb jellies), sponges, placozoans, cnidarians (hydras, jellyfish, corals and sea anemones) and myxozoans. Then we move to the simplest bilaterian animals (with a head, three body cell layers, and bilateral symmetry), the two phyla of flatworms. A key determinant of longevity and immortality in most of these simple animals is the large numbers of pluripotent stem cells that underlie the remarkable abilities of these animals to regenerate and rejuvenate themselves. Finally, we discuss briefly the evolution of the higher bilaterians and how longevity was reduced and immortality lost due to attainment of greater body complexity and cell cycle strategies that protect these complex organisms from developing tumors. We also briefly consider how the evolution of multiple aging-related mechanisms/pathwayshinders our ability to understand and modify the aging process in higher organisms. PMID:24910306

Spontaneously broken Yang-Mills-Einstein supergravities as double copies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiodaroli, Marco; Günaydin, Murat; Johansson, Henrik

Color/kinematics duality and the double-copy construction have proved to be systematic tools for gaining new insight into gravitational theories. Extending our earlier work, in this article we introduce new double-copy constructions for large classes of spontaneously-broken Yang-Mills-Einstein theories with adjoint Higgs elds. One gaugetheory copy entering the construction is a spontaneously-broken (super-)Yang-Mills theory, while the other copy is a bosonic Yang-Mills-scalar theory with trilinear scalar interactions that display an explicitly-broken global symmetry. We show that the kinematic numerators of these gauge theories can be made to obey color/kinematics duality by exhibiting particular additional Lie-algebraic relations. We discuss in detail explicitmore » examples with N = 2 supersymmetry, focusing on Yang-Mills-Einstein supergravity theories belonging to the generic Jordan family in four and five dimensions, and identify the map between the supergravity and double-copy elds and parameters. We also briefly discuss the application of our results to N = 4 supergravity theories. The constructions are illustrated by explicit examples of tree-level and one-loop scattering amplitudes.« less

Spontaneously broken Yang-Mills-Einstein supergravities as double copies

DOE PAGES

Chiodaroli, Marco; Günaydin, Murat; Johansson, Henrik; ...

2017-06-13

Color/kinematics duality and the double-copy construction have proved to be systematic tools for gaining new insight into gravitational theories. Extending our earlier work, in this article we introduce new double-copy constructions for large classes of spontaneously-broken Yang-Mills-Einstein theories with adjoint Higgs elds. One gaugetheory copy entering the construction is a spontaneously-broken (super-)Yang-Mills theory, while the other copy is a bosonic Yang-Mills-scalar theory with trilinear scalar interactions that display an explicitly-broken global symmetry. We show that the kinematic numerators of these gauge theories can be made to obey color/kinematics duality by exhibiting particular additional Lie-algebraic relations. We discuss in detail explicitmore » examples with N = 2 supersymmetry, focusing on Yang-Mills-Einstein supergravity theories belonging to the generic Jordan family in four and five dimensions, and identify the map between the supergravity and double-copy elds and parameters. We also briefly discuss the application of our results to N = 4 supergravity theories. The constructions are illustrated by explicit examples of tree-level and one-loop scattering amplitudes.« less

Responding to the Consequences of Climate Change

NASA Technical Reports Server (NTRS)

Hildebrand, Peter H.

2011-01-01

The talk addresses the scientific consensus concerning climate change, and outlines the many paths that are open to mitigate climate change and its effects on human activities. Diverse aspects of the changing water cycle on Earth are used to illustrate the reality climate change. These include melting snowpack, glaciers, and sea ice; changes in runoff; rising sea level; moving ecosystems, an more. Human forcing of climate change is then explained, including: greenhouse gasses, atmospheric aerosols, and changes in land use. Natural forcing effects are briefly discussed, including volcanoes and changes in the solar cycle. Returning to Earth's water cycle, the effects of climate-induced changes in water resources is presented. Examples include wildfires, floods and droughts, changes in the production and availability of food, and human social reactions to these effects. The lk then passes to a discussion of common human reactions to these forecasts of climate change effects, with a summary of recent research on the subject, plus several recent historical examples of large-scale changes in human behavior that affect the climate and ecosystems. Finally, in the face for needed action on climate, the many options for mitigation of climate change and adaptation to its effects are presented, with examples of the ability to take affordable, and profitable action at most all levels, from the local, through national.

PET and MR imaging: the odd couple or a match made in heaven?

PubMed

Catana, Ciprian; Guimaraes, Alexander R; Rosen, Bruce R

2013-05-01

PET and MR imaging are modalities routinely used for clinical and research applications. Integrated scanners capable of acquiring PET and MR imaging data in the same session, sequentially or simultaneously, have recently become available for human use. In this article, we describe some of the technical advances that allowed the development of human PET/MR scanners; briefly discuss methodologic challenges and opportunities provided by this novel technology; and present potential oncologic, cardiac, and neuropsychiatric applications. These examples range from studies that might immediately benefit from PET/MR to more advanced applications on which future development might have an even broader impact.

Portable computing for taking part of the lab to the sample types of applications. From hand held personal digital assistants to smart phones for mobile spectrometry

NASA Astrophysics Data System (ADS)

Weagant, Scott; Karanassios, Vassili

2015-06-01

The use of portable hand held computing devices for the acquisition of spectrochemical data is briefly discussed using examples from the author's laboratory. Several network topologies are evaluated. At present, one topology that involves a portable computing device for data acquisition and spectrometer control and that has wireless access to the internet at one end and communicates with a smart phone at the other end appears to be better suited for "taking part of the lab to the sample" types of applications. Thus, spectrometric data can be accessed from anywhere in the world.

AVE-Sesame 3: 25-MB sounding data

NASA Technical Reports Server (NTRS)

Williams, S. T.; Gerhard, M. L.; Gilchrist, L. P.; Turner, R. E.

1980-01-01

The rawinsonde sounding program for the AVE-SESAME 3 experiment is described and tabulated data at 25-mb intervals from the surface to 25 mb for the 23 National Weather Service and 19 special stations participating in the experiment are presented. Soundings were taken at 3 hr intervals beginning at 1200 GMT on April 25, 1979, and ending at 1200 GMT on April 26, 1979 (nine sounding times). The method of processing is discussed briefly, estimates of the rms errors in the data presented, an example of contact data given, reasons given for the termination of soundings below 100 mb, and soundings listed which exhibit abnormal characteristics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cottam, Joseph A.; Blaha, Leslie M.

Systems have biases. Their interfaces naturally guide a user toward specific patterns of action. For example, modern word-processors and spreadsheets are both capable of taking word wrapping, checking spelling, storing tables, and calculating formulas. You could write a paper in a spreadsheet or could do simple business modeling in a word-processor. However, their interfaces naturally communicate which function they are designed for. Visual analytic interfaces also have biases. In this paper, we outline why simple Markov models are a plausible tool for investigating that bias and how they might be applied. We also discuss some anticipated difficulties in such modelingmore » and touch briefly on what some Markov model extensions might provide.« less

Failures in large gas turbines due to liquid-metal embrittlement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cameron, D.W.

1994-07-01

The failures of three gas turbine components, attributed to liquid-metal embrittlement or solid-metal-induced embrittlement, are described. High temperatures inherent in the gas turbine can aggravate these phenomenon if the necessary conditions are present. Examples chosen include a power transmission shaft, flange bolts from a cooling steam line, and a turbine rotor bolt. The respective material couples involved are 17-4PH stainless steel-copper, AISI 4130-cadmium, and IN 718-cadmium. Each case includes information on the source of the aggressive material and relevant operating environment. The implications of the failures with regard to the general failure mechanism are briefly discussed.

Dynamic Programming and Graph Algorithms in Computer Vision*

PubMed Central

Felzenszwalb, Pedro F.; Zabih, Ramin

2013-01-01

Optimization is a powerful paradigm for expressing and solving problems in a wide range of areas, and has been successfully applied to many vision problems. Discrete optimization techniques are especially interesting, since by carefully exploiting problem structure they often provide non-trivial guarantees concerning solution quality. In this paper we briefly review dynamic programming and graph algorithms, and discuss representative examples of how these discrete optimization techniques have been applied to some classical vision problems. We focus on the low-level vision problem of stereo; the mid-level problem of interactive object segmentation; and the high-level problem of model-based recognition. PMID:20660950

Advances in modelling of condensation phenomena

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, W.S.; Zaltsgendler, E.; Hanna, B.

1997-07-01

The physical parameters in the modelling of condensation phenomena in the CANDU reactor system codes are discussed. The experimental programs used for thermal-hydraulic code validation in the Canadian nuclear industry are briefly described. The modelling of vapour generation and in particular condensation plays a key role in modelling of postulated reactor transients. The condensation models adopted in the current state-of-the-art two-fluid CANDU reactor thermal-hydraulic system codes (CATHENA and TUF) are described. As examples of the modelling challenges faced, the simulation of a cold water injection experiment by CATHENA and the simulation of a condensation induced water hammer experiment by TUFmore » are described.« less

Applications of yeast surface display for protein engineering

PubMed Central

Cherf, Gerald M.; Cochran, Jennifer R.

2015-01-01

The method of displaying recombinant proteins on the surface of Saccharomyces cerevisiae via genetic fusion to an abundant cell wall protein, a technology known as yeast surface display, or simply, yeast display, has become a valuable protein engineering tool for a broad spectrum of biotechnology and biomedical applications. This review focuses on the use of yeast display for engineering protein affinity, stability, and enzymatic activity. Strategies and examples for each protein engineering goal are discussed. Additional applications of yeast display are also briefly presented, including protein epitope mapping, identification of protein-protein interactions, and uses of displayed proteins in industry and medicine. PMID:26060074

Early Warning Look Ahead Metrics: The Percent Milestone Backlog Metric

NASA Technical Reports Server (NTRS)

Shinn, Stephen A.; Anderson, Timothy P.

2017-01-01

All complex development projects experience delays and corresponding backlogs of their project control milestones during their acquisition lifecycles. NASA Goddard Space Flight Center (GSFC) Flight Projects Directorate (FPD) teamed with The Aerospace Corporation (Aerospace) to develop a collection of Early Warning Look Ahead metrics that would provide GSFC leadership with some independent indication of the programmatic health of GSFC flight projects. As part of the collection of Early Warning Look Ahead metrics, the Percent Milestone Backlog metric is particularly revealing, and has utility as a stand-alone execution performance monitoring tool. This paper describes the purpose, development methodology, and utility of the Percent Milestone Backlog metric. The other four Early Warning Look Ahead metrics are also briefly discussed. Finally, an example of the use of the Percent Milestone Backlog metric in providing actionable insight is described, along with examples of its potential use in other commodities.

The impact of pharmacophore modeling in drug design.

PubMed

Guner, Osman F

2005-07-01

With the reliable use of computer simulations in scientific research, it is possible to achieve significant increases in productivity as well as a reduction in research costs compared with experimental approaches. For example, computer-simulation can substantially enchance productivity by focusing the scientist to better, more informed choices, while also driving the 'fail-early' concept to result in a significant reduction in cost. Pharmacophore modeling is a reliable computer-aided design tool used in the discovery of new classes of compounds for a given therapeutic category. This commentary will briefly review the benefits and applications of this technology in drug discovery and design, and will also highlight its historical evolution. The two most commonly used approaches for pharmacophore model development will be discussed, and several examples of how this technology was successfully applied to identify new potent leads will be provided. The article concludes with a brief outline of the controversial issue of patentability of pharmacophore models.

Coal systems analysis: A new approach to the understanding of coal formation, coal quality and environmental considerations, and coal as a source rock for hydrocarbons

USGS Publications Warehouse

Warwick, Peter D.

2005-01-01

Coal is an important and required energy source for today's world. Current rates of world coal consumption are projected to continue at approximately the same (or greater) levels well into the twenty-first century. This paper will provide an introduction to the concept of coal systems analysis and the accompanying volume of papers will provide examples of how coal systems analysis can be used to understand, characterize, and evaluate coal and coal gas resources. Coal systems analysis incorporates the various disciplines of coal geology to provide a complete characterization of the resource. The coal system is divided into four stages: (1) accumulation, (2) preservation-burial, (3) diagenesis-coalification, and (4) coal and hydrocarbon resources. These stages are briefly discussed and key references and examples of the application of coal systems analysis are provided.

Optical character recognition: an illustrated guide to the frontier

NASA Astrophysics Data System (ADS)

Nagy, George; Nartker, Thomas A.; Rice, Stephen V.

1999-12-01

We offer a perspective on the performance of current OCR systems by illustrating and explaining actual OCR errors made by three commercial devices. After discussing briefly the character recognition abilities of humans and computers, we present illustrated examples of recognition errors. The top level of our taxonomy of the causes of errors consists of Imaging Defects, Similar Symbols, Punctuation, and Typography. The analysis of a series of 'snippets' from this perspective provides insight into the strengths and weaknesses of current systems, and perhaps a road map to future progress. The examples were drawn from the large-scale tests conducted by the authors at the Information Science Research Institute of the University of Nevada, Las Vegas. By way of conclusion, we point to possible approaches for improving the accuracy of today's systems. The talk is based on our eponymous monograph, recently published in The Kluwer International Series in Engineering and Computer Science, Kluwer Academic Publishers, 1999.

Randomized interpolative decomposition of separated representations

NASA Astrophysics Data System (ADS)

Biagioni, David J.; Beylkin, Daniel; Beylkin, Gregory

2015-01-01

We introduce an algorithm to compute tensor interpolative decomposition (dubbed CTD-ID) for the reduction of the separation rank of Canonical Tensor Decompositions (CTDs). Tensor ID selects, for a user-defined accuracy ɛ, a near optimal subset of terms of a CTD to represent the remaining terms via a linear combination of the selected terms. CTD-ID can be used as an alternative to or in combination with the Alternating Least Squares (ALS) algorithm. We present examples of its use within a convergent iteration to compute inverse operators in high dimensions. We also briefly discuss the spectral norm as a computational alternative to the Frobenius norm in estimating approximation errors of tensor ID. We reduce the problem of finding tensor IDs to that of constructing interpolative decompositions of certain matrices. These matrices are generated via randomized projection of the terms of the given tensor. We provide cost estimates and several examples of the new approach to the reduction of separation rank.

'Passive-roof' duplex geometry in the frontal structures of the Kirthar and Sulaiman mountain belts, Pakistan

NASA Astrophysics Data System (ADS)

Banks, C. J.; Warburton, J.

Exploration for hydrocarbons over the past few years has greatly improved our understanding of the geometry of frontal mountain belt structures. In this study we introduce and discuss the concept of the 'Passive-roof duplex', using as the main example the Kirthar and Sulaiman Ranges in the Baluchistan Province of Pakistan. Structures similar to those described here have been recognized previously in other mountain belts, and they appear to exist as a common feature in many more frontal regions of mountain belts. Our example of a Passive-roof duplex which we describe from Pakistan is compared briefly with similar structures reported by others. The Passive-roof duplex is here defined as a duplex whose roof thrust has backthrust sense ( Passive-roof thrust) and whose roof sequence (those rocks lying above the roof thrust) remains relatively 'stationary' during foreland directed piggy-back style propagation of horses within the duplex.

Multi-temporal InSAR Datastacks for Surface Deformation Monitoring: a Review

NASA Astrophysics Data System (ADS)

Ferretti, A.; Novali, F.; Prati, C.; Rocca, F.

2009-04-01

In the last decade extensive processing of thousands of satellite radar scenes acquired by different sensors (e.g. ERS-1/2, ENVISAT and RADARSAT) has demonstrated how multi-temporal data-sets can be successfully exploited for surface deformation monitoring, by identifying objects on the terrain that have a stable, point-like behaviour. These objects, referred to as Permanent or Persistent Scatterers (PS), can be geo-coded and monitored for movement very accurately, acting as a "natural" geodetic network, integrating successfully continuous GPS data. After a brief analysis of both advantages and drawbacks of InSAR datastacks, the paper presents examples of applications of PS measurements for detecting and monitoring active faults, aquifers and oil/gas reservoirs, using experience in Europe, North America and Japan, and concludes with a discussion on future directions for PSInSAR analysis. Special attention is paid to the possibility of creating deformation maps over wide areas using historical archives of data already available. This second part of the paper will briefly discuss the technical features of the new radar sensors recently launched (namely: TerraSAR-X, RADARSAT-2, and CosmoSkyMed) and their impact on space geodesy, highlighting the importance of data continuity and standardized acquisition policies for almost all InSAR and PSInSAR applications. Finally, recent advances in the algorithms applied in PS analysis, such as detection of "temporary PS", PS characterization and exploitation of distributed scatterers, will be briefly discussed based on the processing of real data.

Integrating Computer Architectures into the Design of High-Performance Controllers

NASA Technical Reports Server (NTRS)

Jacklin, Stephen A.; Leyland, Jane A.; Warmbrodt, William

1986-01-01

Modern control systems must typically perform real-time identification and control, as well as coordinate a host of other activities related to user interaction, on-line graphics, and file management. This paper discusses five global design considerations that are useful to integrate array processor, multimicroprocessor, and host computer system architecture into versatile, high-speed controllers. Such controllers are capable of very high control throughput, and can maintain constant interaction with the non-real-time or user environment. As an application example, the architecture of a high-speed, closed-loop controller used to actively control helicopter vibration will be briefly discussed. Although this system has been designed for use as the controller for real-time rotorcraft dynamics and control studies in a wind-tunnel environment, the control architecture can generally be applied to a wide range of automatic control applications.

Experimental design, power and sample size for animal reproduction experiments.

PubMed

Chapman, Phillip L; Seidel, George E

2008-01-01

The present paper concerns statistical issues in the design of animal reproduction experiments, with emphasis on the problems of sample size determination and power calculations. We include examples and non-technical discussions aimed at helping researchers avoid serious errors that may invalidate or seriously impair the validity of conclusions from experiments. Screen shots from interactive power calculation programs and basic SAS power calculation programs are presented to aid in understanding statistical power and computing power in some common experimental situations. Practical issues that are common to most statistical design problems are briefly discussed. These include one-sided hypothesis tests, power level criteria, equality of within-group variances, transformations of response variables to achieve variance equality, optimal specification of treatment group sizes, 'post hoc' power analysis and arguments for the increased use of confidence intervals in place of hypothesis tests.

Wear of seal materials used in aircraft propulsion systems

NASA Technical Reports Server (NTRS)

Bill, R. C.; Ludwig, L. P.

1978-01-01

The various types of seal locations in a gas turbine engine are described, and the significance of wear to each type is reviewed. Starting with positive contact shaft seals, existing material selection guidelines are reviewed, and the existing PV (contact pressure X sliding velocity) criteria for selecting seal materials are discussed, along with the theoretical background for these criteria. Examples of wear mechanisms observed to operate in positive contact seals are shown. Design features that can extend the operating capabilities of positive contact seals, including pressure balancing and incorporation of hydrodynamic lift are briefly discussed. It is concluded that, despite the benefits arising from these design features, improved positive contact seal materials from the standpoint of wear, erosion and oxidation resistance will be necessary for further improvements in seal performance and durability, and to meet stringent future challenges.

25th Anniversary Article: A Soft Future: From Robots and Sensor Skin to Energy Harvesters

PubMed Central

Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

2014-01-01

Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. PMID:24307641

25th anniversary article: A soft future: from robots and sensor skin to energy harvesters.

PubMed

Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

2014-01-08

Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. © 2013 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Multilingualism in South Africa with Particular Reference to the Role of African Languages in Education

NASA Astrophysics Data System (ADS)

Desai, Zubeida

2001-07-01

In this paper it is argued that language policy can play a central role in enabling citizens of a country to participate in the political, educational, social and economic life of that country. Or it can deny them that right. In discussions on the role of African languages, there is a tendency to confine the discussion to language in education. I argue that unless we locate the discussion in a broader context, we are not going to make much progress in extending the use of African languages beyond the home domain. The paper therefore consists of three sections. The first section looks broadly at the domains where language has an impact. The second section briefly outlines a process underway in South Africa to develop a framework for a national language policy, whilst the final section looks at the implications of this for education. Here I look at language in Education Policy in Practice. I give examples from a piece of primary research that I have conducted with Xhosa -speaking Grade 4 and Grade 7 learners who have been given pictures to describe first in Xhosa and then in English. The examples show the rich vocabulary children have when they express themselves in Xhosa and the poor vocabulary they have when they express themselves in English.

Beyond grid security

NASA Astrophysics Data System (ADS)

Hoeft, B.; Epting, U.; Koenig, T.

2008-07-01

While many fields relevant to Grid security are already covered by existing working groups, their remit rarely goes beyond the scope of the Grid infrastructure itself. However, security issues pertaining to the internal set-up of compute centres have at least as much impact on Grid security. Thus, this talk will present briefly the EU ISSeG project (Integrated Site Security for Grids). In contrast to groups such as OSCT (Operational Security Coordination Team) and JSPG (Joint Security Policy Group), the purpose of ISSeG is to provide a holistic approach to security for Grid computer centres, from strategic considerations to an implementation plan and its deployment. The generalised methodology of Integrated Site Security (ISS) is based on the knowledge gained during its implementation at several sites as well as through security audits, and this will be briefly discussed. Several examples of ISS implementation tasks at the Forschungszentrum Karlsruhe will be presented, including segregation of the network for administration and maintenance and the implementation of Application Gateways. Furthermore, the web-based ISSeG training material will be introduced. This aims to offer ISS implementation guidance to other Grid installations in order to help avoid common pitfalls.

Health inequality and non-monotonicity of the health related social welfare function.

PubMed

Dutta, Indranil

2007-03-01

In a recent paper in this journal Abasolo and Tsuchiya [Abasolo, I., Tsuchiya, A., 2004. Exploring social welfare functions and violation of monotonicity: an example from inequalities in health. Journal of Health Economics 23, 313-329] have strongly argued for the use of a non-monotonic health related social welfare function. This note discusses both the limitations of the measure proposed by Abasolo and Tsuchiya [Abasolo, I., Tsuchiya, A., 2004. Exploring social welfare functions and violation of monotonicity: an example from inequalities in health. Journal of Health Economics 23, 313-329] and the problems associated with their empirics. We are able to show how non-monotonicity may lead to paradoxical results and policies. Further we examine the empirics of Abasolo and Tsuchiya [Abasolo, I., Tsuchiya, A., 2004. Exploring social welfare functions and violation of monotonicity: an example from inequalities in health. Journal of Health Economics 23, 313-329] and provide an alternative explanation to the observed patterns in the data that do not violate monotonicity. Finally we briefly mention why the Atkinson-Sen framework may be more appropriate as a way forward.

PET and MRI: The Odd Couple or a Match Made in Heaven?

PubMed Central

Catana, Ciprian; Guimaraes, Alexander R.; Rosen, Bruce R.

2013-01-01

Positron emission tomography (PET) and magnetic resonance imaging (MRI) are imaging modalities routinely used for clinical and research applications. Integrated scanners capable of acquiring PET and MRI data in the same imaging session, sequentially or simultaneously, have recently become available for human use. In this manuscript, we describe some of the technical advances that allowed the development of human PET/MR scanners, briefly discuss methodological challenges and opportunities provided by this novel technology and present potential oncologic, cardiac, and neuro-psychiatric applications. These examples range from studies that might immediately benefit from PET/MR to more advanced applications where future development might have an even broader impact. PMID:23492887

Global geologic applications of the Space Shuttle earth observations photography database

NASA Technical Reports Server (NTRS)

Lulla, Kamlesh; Helfert, Michael; Evans, Cynthia; Wilkinson, M. J.; Pitts, David; Amsbury, David

1993-01-01

The advantages of the astronaut photography during Space Shuttle missions are briefly examined, and the scope and applications of the Space Shuttle earth observations photography database are discussed. The global and multidisciplinary nature of the data base is illustrated by several examples of geologic applications. These include the eruption of Mount Pinatubo (Philippine Islands), heat flow and ice cover on Lake Baikal in Siberia (Russia), and windblown dust in South America. It is noted that hand-held photography from the U.S. Space Shuttle provides unique remotely-sensed data for geologic applications because of the combination of varying perspectives, look angles, and illumination, and changing resolution resulting from different lenses and altitudes.

Succession planning.

PubMed

Catanzaro, Thomas E

2006-03-01

This article provides the reader with an appreciation of the diverse elements that go into a buy-sell, affiliation, or merger situation for veterinary practices. In the changing market place of American veterinary medicine, old paradigms no longer hold comfort. The generational differences are briefly explored herein as well as the new economic realities. A few examples are offered to illustrate just how much variability exists in the current business of veterinary medicine and the subsequent practice transitions needed to enhance value. Functioning models are explored, as well as affiliation and merger options. Practice valuation is discussed in general terms, referencing the cutting-edge factors. The six-point summary provides almost all practices a solid operational base for daily operations and succession planning.

Cancer’s Achilles’ Heel: Apoptosis and Necroptosis to the Rescue

PubMed Central

Dasgupta, Atreyi; Nomura, Motonari; Shuck, Ryan; Yustein, Jason

2016-01-01

Apoptosis, and the more recently discovered necroptosis, are two avenues of programmed cell death. Cancer cells survive by evading these two programs, driven by oncogenes and tumor suppressor genes. While traditional therapy using small molecular inhibitors and chemotherapy are continuously being utilized, a new and exciting approach is actively underway by identifying and using synergistic relationship between driver and rescue genes in a cancer cell. Through these synthetic lethal relationships, we are gaining tremendous insights into tumor vulnerabilities and specific molecular avenues for induction of programmed cell death. In this review, we briefly discuss the two cell death processes and cite examples of such synergistic manipulations for therapeutic purposes. PMID:28025559

Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents

PubMed Central

Wang, Fenglin; Li, Chengyao; Cheng, Jing; Yuan, Zhiqin

2016-01-01

Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning. Emphasis is placed on how these inorganic nanoparticles can provide enhanced therapeutic efficacy in cancer treatment through site-specific accumulation, targeted drug delivery and stimulated drug release, with elaborations on several examples to highlight the respective strategies adopted. Finally, a brief summary and future challenges are included. PMID:27898016

A sessional blind signature based on quantum cryptography

NASA Astrophysics Data System (ADS)

Khodambashi, Siavash; Zakerolhosseini, Ali

2014-01-01

In this paper, we present a sessional blind signature protocol whose security is guaranteed by fundamental principles of quantum physics. It allows a message owner to get his message signed by an authorized signatory. However, the signatory is not capable of reading the message contents and everyone can verify authenticity of the message. For this purpose, we took advantage of a sessional signature as well as quantum entangled pairs which are generated with respect to it in our proposed protocol. We describe our proposed blind signature through an example and briefly discuss about its unconditional security. Due to the feasibility of the protocol, it can be widely employed for e-payment, e-government, e-business and etc.

Development and melt growth of novel scintillating halide crystals

NASA Astrophysics Data System (ADS)

Yoshikawa, Akira; Yokota, Yuui; Shoji, Yasuhiro; Kral, Robert; Kamada, Kei; Kurosawa, Shunsuke; Ohashi, Yuji; Arakawa, Mototaka; Chani, Valery I.; Kochurikhin, Vladimir V.; Yamaji, Akihiro; Andrey, Medvedev; Nikl, Martin

2017-12-01

Melt growth of scintillating halide crystals is reviewed. The vertical Bridgman growth technique is still considered as very popular method that enables production of relatively large and commercially attractive crystals. On the other hand, the micro-pulling-down method is preferable when fabrication of small samples, sufficient for preliminary characterization of their optical and/or scintillation performance, is required. Moreover, bulk crystal growth is also available using the micro-pulling-down furnace. The examples of growths of various halide crystals by industrially friendly melt growth techniques including Czochralski and edge-defined film-fed growth methods are also discussed. Finally, traveling molten zone growth that in some degree corresponds to horizontal zone melting is briefly overviewed.

Current status and prospects of nuclear physics research based on tracking techniques

NASA Astrophysics Data System (ADS)

Alekseev, V. A.; Alexandrov, A. B.; Bagulya, A. V.; Chernyavskiy, M. M.; Goncharova, L. A.; Gorbunov, S. A.; Kalinina, G. V.; Konovalova, N. S.; Okatyeva, N. M.; Pavlova, T. A.; Polukhina, N. G.; Shchedrina, T. V.; Starkov, N. I.; Tioukov, V. E.; Vladymirov, M. S.; Volkov, A. E.

2017-01-01

Results of nuclear physics research made using track detectors are briefly reviewed. Advantages and prospects of the track detection technique in particle physics, neutrino physics, astrophysics and other fields are discussed on the example of the results of the search for direct origination of tau neutrino in a muon neutrino beam within the framework of the international experiment OPERA (Oscillation Project with Emulsion-tRacking Apparatus) and works on search for superheavy nuclei in nature on base of their tracks in meteoritic olivine crystals. The spectra of superheavy elements in galactic cosmic rays are presented. Prospects of using the track detection technique in fundamental and applied research are reported.

The environmental control and life-support system for a lunar base: What drives its design

NASA Technical Reports Server (NTRS)

Hypes, Warren D.; Hall, John B., Jr.

1992-01-01

The purpose of this paper is to identify and briefly discuss some of the ground rules and mission scenario details that become drivers of the environmental control and life support (ECLS) system design and of the logistics related to the design. This paper is written for mission planners and non-ECLS system engineers to inform them of the details that will be important to the ECLS engineer when the design phase is reached. In addition, examples illustrate the impact of some selected mission characteristics on the logistics associated with ECLS systems. The last section of this paper focuses on the ECLS system technology development sequence and highlights specific portions that need emphasis.

Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents.

PubMed

Wang, Fenglin; Li, Chengyao; Cheng, Jing; Yuan, Zhiqin

2016-11-25

Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning. Emphasis is placed on how these inorganic nanoparticles can provide enhanced therapeutic efficacy in cancer treatment through site-specific accumulation, targeted drug delivery and stimulated drug release, with elaborations on several examples to highlight the respective strategies adopted. Finally, a brief summary and future challenges are included.

The alien replicon: Artificial genetic constructs to direct the synthesis of transmissible self-replicating RNAs: In vivo synthesised heterologous (alien) RNA constructs are capable of initiating self-replication following transmission to the host organism.

PubMed

Kochetov, Alex V

2014-12-01

Artificial genetic constructs that direct the synthesis of self-replicating RNA molecules are used widely to induce gene silencing, for bioproduction, and for vaccination. Interestingly, one variant of the self-replicon has not been discussed in the literature: namely, transgenic organisms that synthesise alien replicons. For example, plant cells may be easily genetically modified to produce bacteriophages or insect viruses. Alien replicon-producing organisms (ARPOs) may serve as a unique tool for biocontrol or to selectively influence the characteristics of a target organism. The ARPO approach would have to meet strict biosafety criteria, and its practical applications are problematic. However, a discussion on ARPO applicability would be valuable to outline the full set of options available in the bioengineering toolbox. In this paper, RNA replicons for bioengineering are reviewed briefly, and the ARPO approach is discussed. © 2014 WILEY Periodicals, Inc.

The use of hydrogen for aircraft propulsion in view of the fuel crisis

NASA Technical Reports Server (NTRS)

Weiss, S.

1973-01-01

Some factors influencing the technical feasibility of operating a liquid hydrogen-fueled airplane are discussed in light of the projected decrease of fossil fuels. Other sources of energy, such as wind, tidal, solar, and geothermal, are briefly mentioned. In view of projected decreases in available petroleum fuels, interest has been generated in exploiting the potential of liquid hydrogen (LH2) as an aircraft fuel. Cost studies of LH2 production show it to be more expensive than presently used fuels. Regardless of cost considerations, LH2 is viewed as an attractive aircraft fuel because of the potential performance benefits it offers. Accompanying these benefits, however, are many new problems associated with aircraft design and operations; for example, problems related to fuel system design and the handling of LH2 during ground servicing. Some of the factors influencing LH2 fuel tank design, pumping, heat exchange, and flow regulation are discussed.

Microspheres and Nanotechnology for Drug Delivery.

PubMed

Jóhannesson, Gauti; Stefánsson, Einar; Loftsson, Thorsteinn

2016-01-01

Ocular drug delivery to the posterior segment of the eye can be accomplished by invasive drug injections into different tissues of the eye and noninvasive topical treatment. Invasive treatment involves the risks of surgical trauma and infection, and conventional topical treatments are ineffective in delivering drugs to the posterior segment of the eye. In recent years, nanotechnology has become an ever-increasing part of ocular drug delivery. In the following, we briefly review microspheres and nanotechnology for drug delivery to the eye, including different forms of nanotechnology such as nanoparticles, microparticles, liposomes, microemulsions and micromachines. The permeation barriers and anatomical considerations linked to ocular drug delivery are discussed and a theoretical overview on drug delivery through biological membranes is given. Finally, in vitro, in vivo and human studies of x03B3;-cyclodextrin nanoparticle eyedrop suspensions are discussed as an example of nanotechnology used for drug delivery to the eye. © 2016 S. Karger AG, Basel.

Therapeutic self-disclosure in integrative psychotherapy: When is this a clinical error?

PubMed

Ziv-Beiman, Sharon; Shahar, Golan

2016-09-01

Ascending to prominence in virtually all forms of psychotherapy, therapist self-disclosure (TSD) has recently been identified as a primarily integrative intervention (Ziv-Beiman, 2013). In the present article, we discuss various instances in which using TSD in integrative psychotherapy might constitute a clinical error. First, we briefly review extant theory and empirical research on TSD, followed by our preferred version of integrative psychotherapy (i.e., a version of Wachtel's Cyclical Psychodynamics [Wachtel, 1977, 1997, 2014]), which we title cognitive existential psychodynamics. Next, we provide and discuss three examples in which implementing TSD constitutes a clinical error. In essence, we submit that using TSD constitutes an error when patients, constrained by their representational structures (object relations), experience the subjectivity of the other as impinging, and thus propels them to "react" instead of "emerge." (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Firms, crowds, and innovation.

PubMed

Felin, Teppo; Lakhani, Karim R; Tushman, Michael L

2017-05-01

The purpose of this article is to suggest a (preliminary) taxonomy and research agenda for the topic of "firms, crowds, and innovation" and to provide an introduction to the associated special issue. We specifically discuss how various crowd-related phenomena and practices-for example, crowdsourcing, crowdfunding, user innovation, and peer production-relate to theories of the firm, with particular attention on "sociality" in firms and markets. We first briefly review extant theories of the firm and then discuss three theoretical aspects of sociality related to crowds in the context of strategy, organizations, and innovation: (1) the functions of sociality (sociality as extension of rationality, sociality as sensing and signaling, sociality as matching and identity), (2) the forms of sociality (independent/aggregate and interacting/emergent forms of sociality), and (3) the failures of sociality (misattribution and misapplication). We conclude with an outline of future research directions and introduce the special issue papers and essays.

Relativistic Length Agony Continued

NASA Astrophysics Data System (ADS)

Redzic, D. V.

2014-06-01

We made an attempt to remedy recent confusing treatments of some basic relativistic concepts and results. Following the argument presented in an earlier paper (Redzic 2008b), we discussed the misconceptions that are recurrent points in the literature devoted to teaching relativity such as: there is no change in the object in Special Relativity, illusory character of relativistic length contraction, stresses and strains induced by Lorentz contraction, and related issues. We gave several examples of the traps of everyday language that lurk in Special Relativity. To remove a possible conceptual and terminological muddle, we made a distinction between the relativistic length reduction and relativistic FitzGerald-Lorentz contraction, corresponding to a passive and an active aspect of length contraction, respectively; we pointed out that both aspects have fundamental dynamical contents. As an illustration of our considerations, we discussed briefly the Dewan-Beran-Bell spaceship paradox and the 'pole in a barn' paradox.

Privacy revisited? Old ideals, new realities, and their impact on biobank regimes.

PubMed

Bialobrzeski, Arndt; Ried, Jens; Dabrock, Peter

2011-11-01

Biobanks, collecting human specimen, medical records, and lifestyle-related data, face the challenge of having contradictory missions: on the one hand serving the collective welfare through easy access for medical research, on the other hand adhering to restrictive privacy expectations of people in order to maintain their willingness to participate in such research. In this article, ethical frameworks stressing the societal value of low-privacy expectations in order to secure biomedical research are discussed. It will turn out that neither utilitarian nor communitarian or classical libertarian ethics frameworks will help to serve both goals. Instead, John Rawls' differentiation of the "right" and the "good" is presented in order to illustrate the possibility of "serving two masters": individual interests of privacy, and societal interests of scientific progress and intergenerational justice. In order to illustrate this counterbalancing concept with an example, the five-pillar concept of the German Ethics Council will be briefly discussed.

How can wireless, mobile data acquisition be used for taking part of the lab to the sample, and how can it join the internet of things?

NASA Astrophysics Data System (ADS)

Trzcinski, Peter; Karanassios, Vassili

2016-05-01

During the last several years, the world has moved from wired communications (e.g., a wired ethernet, wired telephone) to wireless communications (e.g., cell phones, smart phones, tablets). However, data acquisition has lagged behind and for the most part, data in laboratory settings are still acquired using wired communications (or even plug in boards). In this paper, approaches that can be used for wireless data acquisition are briefly discussed using a conceptual model of a future, mobile, portable micro-instrument as an example. In addition, past, present and near-future generations of communications are discussed; processors, operating systems and benchmarks are reviewed; networks that may be used for data acquisition in the field are examined; and, the possibility of connecting sensor or micro-instrument networks to the internet of things is postulated.

Symptom overreporting and dissociative experiences: A qualitative review.

PubMed

Merckelbach, H; Boskovic, I; Pesy, D; Dalsklev, M; Lynn, S J

2017-03-01

We discuss a phenomenon that has received little attention to date in research on dissociative phenomena, namely that self-reports of these phenomena overlap with the tendency to overendorse eccentric items. We review the literature documenting the dissociation-overreporting link and then briefly discuss various interpretations of this link: (1) overreporting is an artifact of measuring dissociative symptoms; (2) dissociative psychopathology engenders overreporting of eccentric symptoms through fantasy proneness or impairments in internal monitoring; (3) an overreporting response style as is evident in malingerers, for example, promotes reports of dissociative symptoms. These three interpretations are not mutually exclusive. Also, the dissociation-overreporting link may have different origins among different samples. Because overreporting may introduce noise in datasets, we need more research specifically aimed at disentangling the dissociation-overreporting link. We suggest various avenues to accomplish this goal. Copyright © 2017 Elsevier Inc. All rights reserved.

Recursivity in Lingua Cosmica

NASA Astrophysics Data System (ADS)

Ollongren, Alexander

2011-02-01

In a sequence of papers on the topic of message construction for interstellar communication by means of a cosmic language, the present author has discussed various significant requirements such a lingua should satisfy. The author's Lingua Cosmica is a (meta) system for annotating contents of possibly large-scale messages for ETI. LINCOS, based on formal constructive logic, was primarily designed for dealing with logic contents of messages but is also applicable for denoting structural properties of more general abstractions embedded in such messages. The present paper explains ways and means for achieving this for a special case: recursive entities. As usual two stages are involved: first the domain of discourse is enriched with suitable representations of the entities concerned, after which properties over them can be dealt with within the system itself. As a representative example the case of Russian dolls (Matrjoshka's) is discussed in some detail and relations with linguistic structures in natural languages are briefly exploited.

Identical Bands: Does ``Seeing Double'' Mean We Learn Twice as Much?

NASA Astrophysics Data System (ADS)

Fallon, Paul

1996-10-01

The phenomenon of `identical bands' has been under discussion for several years, however the origin of this surprising observation, whereby rotational cascades in different nuclei exhibit very similar transition energies (and/or moments of inertia), remains uncertain. The first cases of identical superdeformed bands were observed when only a small number of superdeformed bands were known. Since then many more examples of superdeformation have been found and it is important to see if the number of `identical' bands has risen in proportion. In addition the `identical' band discussion has been extended to normal deformed nuclei. In this talk I will briefly review the topic of identical bands and attempt to address the progress made and add some personal views on what remains to be done. Work supported in part by the U.S. DOE under contract number DE-AC03-76SF0098.

Firms, crowds, and innovation

PubMed Central

Felin, Teppo; Lakhani, Karim R; Tushman, Michael L

2017-01-01

The purpose of this article is to suggest a (preliminary) taxonomy and research agenda for the topic of “firms, crowds, and innovation” and to provide an introduction to the associated special issue. We specifically discuss how various crowd-related phenomena and practices—for example, crowdsourcing, crowdfunding, user innovation, and peer production—relate to theories of the firm, with particular attention on “sociality” in firms and markets. We first briefly review extant theories of the firm and then discuss three theoretical aspects of sociality related to crowds in the context of strategy, organizations, and innovation: (1) the functions of sociality (sociality as extension of rationality, sociality as sensing and signaling, sociality as matching and identity), (2) the forms of sociality (independent/aggregate and interacting/emergent forms of sociality), and (3) the failures of sociality (misattribution and misapplication). We conclude with an outline of future research directions and introduce the special issue papers and essays. PMID:28690428

High-speed, automatic controller design considerations for integrating array processor, multi-microprocessor, and host computer system architectures

NASA Technical Reports Server (NTRS)

Jacklin, S. A.; Leyland, J. A.; Warmbrodt, W.

1985-01-01

Modern control systems must typically perform real-time identification and control, as well as coordinate a host of other activities related to user interaction, online graphics, and file management. This paper discusses five global design considerations which are useful to integrate array processor, multimicroprocessor, and host computer system architectures into versatile, high-speed controllers. Such controllers are capable of very high control throughput, and can maintain constant interaction with the nonreal-time or user environment. As an application example, the architecture of a high-speed, closed-loop controller used to actively control helicopter vibration is briefly discussed. Although this system has been designed for use as the controller for real-time rotorcraft dynamics and control studies in a wind tunnel environment, the controller architecture can generally be applied to a wide range of automatic control applications.

Optimized exploration resource evaluation using the MDT tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zainun, K.; Trice, M.L.

1995-10-01

This paper discusses exploration cost reduction and improved resource delineation benefits that were realized by use of the MDT (Modular Formation Dynamic Tester) tool to evaluate exploration prospects in the Malay Basin of the South China Sea. Frequently, open hole logs do not clearly define fluid content due to low salinity of the connate water and the effect of shale laminae or bioturbation in the silty, shaley sandstones. Therefore, extensive pressure measurements and fluid sampling are required to define fluid type and contacts. This paper briefly describes the features of the MDT tool which were utilized to reduce rig timemore » usage while providing more representative fluid samples and illustrates usage of these features with field examples. The tool has been used on several exploration wells and a comparison of MDT pressures and samples to results obtained with earlier vintage tools and production tests is also discussed.« less

EVA Development and Verification Testing at NASA's Neutral Buoyancy Laboratory

NASA Technical Reports Server (NTRS)

Jairala, Juniper; Durkin, Robert

2012-01-01

As an early step in preparing for future EVAs, astronauts perform neutral buoyancy testing to develop and verify EVA hardware and operations. To date, neutral buoyancy demonstrations at NASA JSC’s Sonny Carter Training Facility have primarily evaluated assembly and maintenance tasks associated with several elements of the ISS. With the retirement of the Space Shuttle, completion of ISS assembly, and introduction of commercial participants for human transportation into space, evaluations at the NBL will take on a new focus. In this session, Juniper Jairala briefly discussed the design of the NBL and, in more detail, described the requirements and process for performing a neutral buoyancy test, including typical hardware and support equipment requirements, personnel and administrative resource requirements, examples of ISS systems and operations that are evaluated, and typical operational objectives that are evaluated. Robert Durkin discussed the new and potential types of uses for the NBL, including those by non-NASA external customers.

EVA Development and Verification Testing at NASA's Neutral Buoyancy Laboratory

NASA Technical Reports Server (NTRS)

Jairala, Juniper; Durkin, Robert

2012-01-01

As an early step in preparing for future EVAs, astronauts perform neutral buoyancy testing to develop and verify EVA hardware and operations. To date, neutral buoyancy demonstrations at NASA JSC's Sonny Carter Training Facility have primarily evaluated assembly and maintenance tasks associated with several elements of the ISS. With the retirement of the Space Shuttle, completion of ISS assembly, and introduction of commercial participants for human transportation into space, evaluations at the NBL will take on a new focus. In this session, Juniper Jairala briefly discussed the design of the NBL and, in more detail, described the requirements and process for performing a neutral buoyancy test, including typical hardware and support equipment requirements, personnel and administrative resource requirements, examples of ISS systems and operations that are evaluated, and typical operational objectives that are evaluated. Robert Durkin discussed the new and potential types of uses for the NBL, including those by non-NASA external customers.

Optical Generation of Fuzzy-Based Rules

NASA Astrophysics Data System (ADS)

Gur, Eran; Mendlovic, David; Zalevsky, Zeev

2002-08-01

In the last third of the 20th century, fuzzy logic has risen from a mathematical concept to an applicable approach in soft computing. Today, fuzzy logic is used in control systems for various applications, such as washing machines, train-brake systems, automobile automatic gear, and so forth. The approach of optical implementation of fuzzy inferencing was given by the authors in previous papers, giving an extra emphasis to applications with two dominant inputs. In this paper the authors introduce a real-time optical rule generator for the dual-input fuzzy-inference engine. The paper briefly goes over the dual-input optical implementation of fuzzy-logic inferencing. Then, the concept of constructing a set of rules from given data is discussed. Next, the authors show ways to implement this procedure optically. The discussion is accompanied by an example that illustrates the transformation from raw data into fuzzy set rules.

Bioterrorism for the respiratory physician.

PubMed

Waterer, Grant W; Robertson, Hannah

2009-01-01

Terrorist attacks by definition are designed to cause fear and panic. There is no question that a terrorist attack using biological agents would present a grave threat to stability of the society in which they were released. Early recognition of such a bioterrorist attack is crucial to containing the damage they could cause. As many of the most likely bioterrorism agents present with pulmonary disease, respiratory physicians may be crucial in the initial recognition and diagnosis phase, and certainly would be drawn into treatment of affected individuals. This review focuses on the biological agents thought most likely to be used by terrorists that have predominantly respiratory presentations. The primary focus of this review is on anthrax, plague, tularaemia, ricin, and Staphylococcal enterotoxin B. The pathogenesis, clinical manifestations and treatment of these agents will be discussed as well as historical examples of their use. Other potential bioterrorism agents with respiratory manifestations will also be discussed briefly.

Using Video for Microanalysis of Teachers' Embodied Pedagogical Practices

ERIC Educational Resources Information Center

Tobin, Joseph; Hayashi, Akiko

2015-01-01

This paper briefly reviews theories of embodiment and then provides an example from our recent work on how we use video in our comparative studies of preschools to highlight embodied and implicit cultural pedagogies. The example we present focuses on how Japanese preschool teachers use the Japanese cultural practice of "mimamoru"…

Laboratory identification of arthropod ectoparasites.

PubMed

Mathison, Blaine A; Pritt, Bobbi S

2014-01-01

The collection, handling, identification, and reporting of ectoparasitic arthropods in clinical and reference diagnostic laboratories are discussed in this review. Included are data on ticks, mites, lice, fleas, myiasis-causing flies, and bed bugs. The public health importance of these organisms is briefly discussed. The focus is on the morphological identification and proper handling and reporting of cases involving arthropod ectoparasites, particularly those encountered in the United States. Other arthropods and other organisms not of public health concern, but routinely submitted to laboratories for identification, are also briefly discussed.

Mission and surface infrastructure concepts

NASA Technical Reports Server (NTRS)

Butler, J.; Mcdaniel, S. G.

1986-01-01

Several types of manned Mars surface missions, including sorties, fixed-base, and hybrid missions, which can be envisioned as potentially desirable approaches to the exploration and utilization of Mars are identified and discussed. Some of the advantages and disadvantages of each type are discussed briefly. Also, some of the implications of the types of missions on the surface elements' design are discussed briefly. Typical sets of surface elements are identified for each type of mission, and weights are provided for each element and set.

Frequency Spectrum for New Aviation Data Links: Initial Study Results

NASA Technical Reports Server (NTRS)

Matolak, David W.; Branstetter, James R.

2004-01-01

We describe results from an initial study to assess the suitability of various spectral bands for supporting the deployment of new aviation data links (ADL). The study focused on systems and spectral bands that can deliver VHF data link (VDL)-or-higher data rates in a two-way communication setting, including air-ground, ground-air, and air-air modes of operation. In the first part of our paper, we briefly discuss the current situation regarding communications, navigation, and surveillance (CNS) links and existing spectrum, and the well-known need for new aviation data links. We next provide an overview of related systems, and discuss key factors involved in the use of spectrum in various bands for any future integrated CNS data link, addressing primarily the lower few layers of the communications protocol stack. Desired attributes of a new ADL system are discussed, and the beneficial aspects of a particular transmission technique spread spectrum are summarized. We also provide a short list of several example potential spectral regions, and note that while none of the existing systems will likely meet the full range of desired features of a new ADL, several systems and spectral regions offer promise in terms of one or more characteristics. A detailed discussion and evaluation of these spectral regions is proposed as future work. We include a few brief examples to illustrate initial technical results regarding spread spectrum overlay, also a subject for future work.

Research status of wave energy conversion (WEC) device of raft structure

NASA Astrophysics Data System (ADS)

Dong, Jianguo; Gao, Jingwei; Tao, Liang; Zheng, Peng

2017-10-01

This paper has briefly described the concept of wave energy generation and six typical conversion devices. As for raft structure, detailed analysis is provided from its development process to typical devices. Taking the design process and working principle of Plamis as an example, the general principle of raft structure is briefly described. After that, a variety of raft structure models are introduced. Finally, the advantages and disadvantages, and development trend of raft structure are pointed out.

Wave Phenomena in Reaction-Diffusion Systems

NASA Astrophysics Data System (ADS)

Steinbock, Oliver; Engel, Harald

2013-12-01

Pattern formation in excitable and oscillatory reaction-diffusion systems provides intriguing examples for the emergence of macroscopic order from molecular reaction events and Brownian motion. Here we review recent results on several aspects of excitation waves including anomalous dispersion, vortex pinning, and three-dimensional scroll waves. Anomalies in the speed-wavelength dependence of pulse trains include nonmonotonic behavior, bistability, and velocity gaps. We further report on the hysteresis effects during the pinning-depinning transition of twodimensional spiral waves. The pinning of three-dimensional scroll waves shows even richer dynamic complexity, partly due to the possibility of geometric and topological mismatches between the unexcitable, pinning heterogeneities and the one-dimensional rotation backbone of the vortex. As examples we present results on the pinning of scroll rings to spherical, C-shaped, and genus-2-type heterogeneities. We also review the main results of several experimental studies employing the Belousov-Zhabotinsky reaction and briefly discuss the biomedical relevance of this research especially in the context of cardiology.

An Energy-Based Limit State Function for Estimation of Structural Reliability in Shock Environments

DOE PAGES

Guthrie, Michael A.

2013-01-01

limit state function is developed for the estimation of structural reliability in shock environments. This limit state function uses peak modal strain energies to characterize environmental severity and modal strain energies at failure to characterize the structural capacity. The Hasofer-Lind reliability index is briefly reviewed and its computation for the energy-based limit state function is discussed. Applications to two degree of freedom mass-spring systems and to a simple finite element model are considered. For these examples, computation of the reliability index requires little effort beyond a modal analysis, but still accounts for relevant uncertainties in both the structure and environment.more » For both examples, the reliability index is observed to agree well with the results of Monte Carlo analysis. In situations where fast, qualitative comparison of several candidate designs is required, the reliability index based on the proposed limit state function provides an attractive metric which can be used to compare and control reliability.« less

Numerically stable finite difference simulation for ultrasonic NDE in anisotropic composites

NASA Astrophysics Data System (ADS)

Leckey, Cara A. C.; Quintanilla, Francisco Hernando; Cole, Christina M.

2018-04-01

Simulation tools can enable optimized inspection of advanced materials and complex geometry structures. Recent work at NASA Langley is focused on the development of custom simulation tools for modeling ultrasonic wave behavior in composite materials. Prior work focused on the use of a standard staggered grid finite difference type of mathematical approach, by implementing a three-dimensional (3D) anisotropic Elastodynamic Finite Integration Technique (EFIT) code. However, observations showed that the anisotropic EFIT method displays numerically unstable behavior at the locations of stress-free boundaries for some cases of anisotropic materials. This paper gives examples of the numerical instabilities observed for EFIT and discusses the source of instability. As an alternative to EFIT, the 3D Lebedev Finite Difference (LFD) method has been implemented. The paper briefly describes the LFD approach and shows examples of stable behavior in the presence of stress-free boundaries for a monoclinic anisotropy case. The LFD results are also compared to experimental results and dispersion curves.

Part two: Alsen - from rural to ruin an example of environmental racism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robinson, F.T.

The small community of Alsen provides and excellent example of how environmental racism can affect an area. However, before I discuss Alsen and its many problems, the author feels it is important to first briefly explain what environmental racism means to me, and second, distinguish environmental racism from environmental injustice. Environmental racism is a subtle form of racism that has not so subtle effects. It often has historical roots, where the initial problem was created many years ago by society's racism, with the practices then becoming entrenched in the system or institutionalized. In contrast, environmental injustice is broader than environmentalmore » racism because it includes Whites, as well as People of Color. In environmental injustice, socioeconomic class is the over-riding issue. Just as with environmental racism, it may have historical roots, and the practices may also become entrenched in the system. Political power, or the lack thereof, is the common thread interwoven between both concepts.« less

Multiplexed Electrochemical Immunosensors for Clinical Biomarkers

PubMed Central

Yáñez-Sedeño, Paloma; Campuzano, Susana; Pingarrón, José M.

2017-01-01

Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detection and personalized therapy and will simplify the diagnosis providing more information in less time. In this field, electrochemical immunosensors have demonstrated to offer interesting alternatives against conventional strategies due to their simplicity, fast response, low cost, high sensitivity and compatibility with multiplexed determination, microfabrication technology and decentralized determinations, features which made them very attractive for integration in point-of-care (POC) devices. Therefore, in this review, the relevance and current challenges of multiplexed determination of clinical biomarkers are briefly introduced, and an overview of the electrochemical immunosensing platforms developed so far for this purpose is given in order to demonstrate the great potential of these methodologies. After highlighting the main features of the selected examples, the unsolved challenges and future directions in this field are also briefly discussed. PMID:28448466

Increased Reliability of Gas Turbine Components by Robust Coatings Manufacturing

NASA Astrophysics Data System (ADS)

Sharma, A.; Dudykevych, T.; Sansom, D.; Subramanian, R.

2017-08-01

The expanding operational windows of the advanced gas turbine components demand increasing performance capability from protective coating systems. This demand has led to the development of novel multi-functional, multi-materials coating system architectures over the last years. In addition, the increasing dependency of components exposed to extreme environment on protective coatings results in more severe penalties, in case of a coating system failure. This emphasizes that reliability and consistency of protective coating systems are equally important to their superior performance. By means of examples, this paper describes the effects of scatter in the material properties resulting from manufacturing variations on coating life predictions. A strong foundation in process-property-performance correlations as well as regular monitoring and control of the coating process is essential for robust and well-controlled coating process. Proprietary and/or commercially available diagnostic tools can help in achieving these goals, but their usage in industrial setting is still limited. Various key contributors to process variability are briefly discussed along with the limitations of existing process and product control methods. Other aspects that are important for product reliability and consistency in serial manufacturing as well as advanced testing methodologies to simplify and enhance product inspection and improve objectivity are briefly described.

Application of point-diffraction interferometry to testing infrared imaging systems

NASA Astrophysics Data System (ADS)

Smartt, Raymond N.; Paez, Gonzalo

2004-11-01

Point-diffraction interferometry has found wide applications spanning much of the electromagnetic spectrum, including both near- and far-infrared wavelengths. Any telescopic, spectroscopic or other imaging system that converts an incident plane or spherical wavefront into an accessible point-like image can be tested at an intermediate image plane or at the principal image plane, in situ. Angular field performance can be similarly tested with inclined incident wavefronts. Any spatially coherent source can be used, but because of the available flux, it is most convenient to use a laser source. The simplicity of the test setup can allow testing of even large and complex fully-assembled systems. While purely reflective IR systems can be conveniently tested at visible wavelengths (apart from filters), catadioptric systems could be evaluated using an appropriate source and an IRPDI, with an imaging and recording system. PDI operating principles are briefly reviewed, and some more recent developments and interesting applications briefly discussed. Alternative approaches and recommended procedures for testing IR imaging systems, including the thermal IR, are suggested. An example of applying point-diffraction interferometry to testing a relatively low angular-resolution, optically complex IR telescopic system is presented.

Phase-Field Modeling of Polycrystalline Solidification: From Needle Crystals to Spherulites—A Review

NASA Astrophysics Data System (ADS)

Gránásy, László; Rátkai, László; Szállás, Attila; Korbuly, Bálint; Tóth, Gyula I.; Környei, László; Pusztai, Tamás

2014-04-01

Advances in the orientation-field-based phase-field (PF) models made in the past are reviewed. The models applied incorporate homogeneous and heterogeneous nucleation of growth centers and several mechanisms to form new grains at the perimeter of growing crystals, a phenomenon termed growth front nucleation. Examples for PF modeling of such complex polycrystalline structures are shown as impinging symmetric dendrites, polycrystalline growth forms (ranging from disordered dendrites to spherulitic patterns), and various eutectic structures, including spiraling two-phase dendrites. Simulations exploring possible control of solidification patterns in thin films via external fields, confined geometry, particle additives, scratching/piercing the films, etc. are also displayed. Advantages, problems, and possible solutions associated with quantitative PF simulations are discussed briefly.

Dielectric elastomers: from the beginning of modern science to applications in actuators and energy harvesters

NASA Astrophysics Data System (ADS)

Baumgartner, Richard; Keplinger, Christoph; Kaltseis, Rainer; Schwödiauer, Reinhard; Bauer, Siegfried

2011-04-01

Electrically deformable materials have a long history, with first quotations in a letter from Alessandro Volta. The topic turned out to be hot at the end of the 19th century, with a landmark paper of Röntgen anticipating the dielectric elastomer principle. In 2000, Pelrine and co-workers generated huge interest in such soft actuators, by demonstrating voltage induced huge area expansion rates of more than 300%. Since then, the field became mature, with first commercial applications appearing on the market. New frontiers also emerged recently, for example by using dielectric transducers in a reverse mode for scavenging mechanical energy. In the present survey we briefly discuss the latest developments in the field.

Deciphering the mechanisms of binding induced folding at nearly atomic resolution: The Φ value analysis applied to IDPs.

PubMed

Gianni, Stefano; Dogan, Jakob; Jemth, Per

2014-01-01

The Φ value analysis is a method to analyze the structure of metastable states in reaction pathways. Such a methodology is based on the quantitative analysis of the effect of point mutations on the kinetics and thermodynamics of the probed reaction. The Φ value analysis is routinely used in protein folding studies and is potentially an extremely powerful tool to analyze the mechanism of binding induced folding of intrinsically disordered proteins. In this review we recapitulate the key equations and experimental advices to perform the Φ value analysis in the perspective of the possible caveats arising in intrinsically disordered systems. Finally, we briefly discuss some few examples already available in the literature.

Phase retrieval of images using Gaussian radial bases.

PubMed

Trahan, Russell; Hyland, David

2013-12-20

Here, the possibility of a noniterative solution to the phase retrieval problem is explored. A new look is taken at the phase retrieval problem that reveals that knowledge of a diffraction pattern's frequency components is enough to recover the image without projective iterations. This occurs when the image is formed using Gaussian bases that give the convenience of a continuous Fourier transform existing in a compact form where square pixels do not. The Gaussian bases are appropriate when circular apertures are used to detect the diffraction pattern because of their optical transfer functions, as discussed briefly. An algorithm is derived that is capable of recovering an image formed by Gaussian bases from only the Fourier transform's modulus, without background constraints. A practical example is shown.

Genetic stability and instability of the cis-acting control element of the 5' untranslated region of the poliovirus RNA.

PubMed

Agol, V I

1993-01-01

The poliovirus genome exhibits tremendous plasticity, which is particularly evident when mutations diminishing the growth potential are introduced into the genome. An amazing variability can be observed even among the genomes derived from a single plaque. Not less amazing is the stability of the viral RNA sequences, which could be revealed, for example, upon the analysis of populations of a given viral strain separated by many cycles of reproduction in different laboratories but under standard conditions. This stability is obviously due to very strong selection for the "fit" phenotype. Implications of both the stability and instability of the poliovirus genome for the design, production and use of live poliovirus vaccines are briefly discussed.

Education in space science

NASA Astrophysics Data System (ADS)

Philbrick, C. Russell

2005-08-01

The educational process for teaching space science has been examined as a topic at the 17th European Space Agency Symposium on European Rocket and Balloon, and Related Research. The approach used for an introductory course during the past 18 years at Penn State University is considered as an example. The opportunities for using space science topics to motivate the thinking and efforts of advanced undergraduate and beginning graduate students are examined. The topics covered in the introductory course are briefly described in an outline indicating the breath of the material covered. Several additional topics and assignments are included to help prepare the students for their careers. These topics include discussions on workplace ethics, project management, tools for research, presentation skills, and opportunities to participate in student projects.

How Far do Ciliate Flagships Sail? A Proposed Gondawanaland Endemic Species at Anchor in Idaho Soils.

PubMed

Bourland, William

2017-07-01

In terms of protist biogeography, "flagship species" (Foissner 2005) have been defined as those so remarkable or "showy" that they are unlikely to be overlooked when present in a given habitat. On this basis, flagship species have been suggested as an ideal or ultimate test for the existence of protist endemism. One example of a flagship ciliate is the terrestrial lepidosome-bearing trachelophyllid, Luporinophrys micelae, previously thought to be a Gondwanan endemic. This report comprises a morphologic description of two populations of L. micelae from Laurentian soils (Idaho, Northwest USA). The flagship concept is briefly reviewed and ciliate biogeography is discussed in light of these findings. Copyright © 2017 Elsevier GmbH. All rights reserved.

Frequency-domain ultrasound waveform tomography breast attenuation imaging

NASA Astrophysics Data System (ADS)

Sandhu, Gursharan Yash Singh; Li, Cuiping; Roy, Olivier; West, Erik; Montgomery, Katelyn; Boone, Michael; Duric, Neb

2016-04-01

Ultrasound waveform tomography techniques have shown promising results for the visualization and characterization of breast disease. By using frequency-domain waveform tomography techniques and a gradient descent algorithm, we have previously reconstructed the sound speed distributions of breasts of varying densities with different types of breast disease including benign and malignant lesions. By allowing the sound speed to have an imaginary component, we can model the intrinsic attenuation of a medium. We can similarly recover the imaginary component of the velocity and thus the attenuation. In this paper, we will briefly review ultrasound waveform tomography techniques, discuss attenuation and its relations to the imaginary component of the sound speed, and provide both numerical and ex vivo examples of waveform tomography attenuation reconstructions.

Molecules as Drives and Witnesses of Star Formation

NASA Astrophysics Data System (ADS)

Shustov, B. M.

2017-07-01

The progress in understanding the role of molecules in star formation is discussed. After very brief introduction which we note in that no star formation would be possible without molecules at the dawn of the Universe and that molecules are important drivers and witnesses of star formation in the current epoch, we consider observational technologies and emphasize the prospective role of UV observations. Special attention is paid to possibilities of UV spectroscopy with coming space observatory Spektr-UF (World Space Observatory - Ultraviolet; WSO-UV). Only one example (observations of CO-dark clouds) from vast scientific program of the WSO-UV is mentioned. Also very briefly disclosed is a model approach to study complex evolution of very young (prestellar) object focusing on chemical (molecular) evolution.

Content-Based Medical Image Retrieval

NASA Astrophysics Data System (ADS)

Müller, Henning; Deserno, Thomas M.

This chapter details the necessity for alternative access concepts to the currently mainly text-based methods in medical information retrieval. This need is partly due to the large amount of visual data produced, the increasing variety of medical imaging data and changing user patterns. The stored visual data contain large amounts of unused information that, if well exploited, can help diagnosis, teaching and research. The chapter briefly reviews the history of image retrieval and its general methods before technologies that have been developed in the medical domain are focussed. We also discuss evaluation of medical content-based image retrieval (CBIR) systems and conclude with pointing out their strengths, gaps, and further developments. As examples, the MedGIFT project and the Image Retrieval in Medical Applications (IRMA) framework are presented.

Understanding physiology by acting out concepts.

PubMed

Yucha, C B

1995-12-01

Typically, classes in anatomy and physiology are taught via lecture and visual aids. This seems to work well for students who are primarily auditory and visual learners but not for those who learn better through kinesthetic experiences. This is the first report describing the use of improvisation to act out physiological concepts within an anatomy and physiology course. Improvisational techniques encourage active participation and allow students to personally interact with and experience difficult concepts in the classroom. In this paper, sensory modality preferences for learning will be discussed briefly. Improvisational techniques will be described, and examples of improvisations useful to convey intricate physiological concepts will be provided. Last, student responses to the use of improvisational techniques in an anatomy and physiology course will be reported.

Electrochemical sensing of heavy metal ions with inorganic, organic and bio-materials.

PubMed

Cui, Lin; Wu, Jie; Ju, Huangxian

2015-01-15

As heavy metal ions severely harm human health, it is important to develop simple, sensitive and accurate methods for their detection in environment and food. Electrochemical detection featured with short analytical time, low power cost, high sensitivity and easy adaptability for in-situ measurement is one of the most developed methods. This review introduces briefly the recent achievements in electrochemical sensing of heavy metal ions with inorganic, organic and bio-materials modified electrodes. In particular, the unique properties of inorganic nanomaterials, organic small molecules or their polymers, enzymes and nucleic acids for detection of heavy metal ions are highlighted. By employing some representative examples, the design and sensing mechanisms of these electrodes are discussed. Copyright © 2014 Elsevier B.V. All rights reserved.

Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora

NASA Astrophysics Data System (ADS)

Saucedo-Morales Julio; Loera-González, Pablo

2013-05-01

We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects.

Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora.

PubMed

Saucedo-Morales, Julio; Loera-González, Pablo

2013-05-01

We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects.

Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora

PubMed Central

Saucedo-Morales, Julio; Loera-González, Pablo

2013-01-01

We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects. PMID:25685436

Thermodynamics and Kinetics of Prenucleation Clusters, Classical and Non-Classical Nucleation

PubMed Central

Zahn, Dirk

2015-01-01

Recent observations of prenucleation species and multi-stage crystal nucleation processes challenge the long-established view on the thermodynamics of crystal formation. Here, we review and generalize extensions to classical nucleation theory. Going beyond the conventional implementation as has been used for more than a century now, nucleation inhibitors, precursor clusters and non-classical nucleation processes are rationalized as well by analogous concepts based on competing interface and bulk energy terms. This is illustrated by recent examples of species formed prior to/instead of crystal nucleation and multi-step nucleation processes. Much of the discussed insights were obtained from molecular simulation using advanced sampling techniques, briefly summarized herein for both nucleation-controlled and diffusion-controlled aggregate formation. PMID:25914369

A review of Reynolds stress models for turbulent shear flows

NASA Technical Reports Server (NTRS)

Speziale, Charles G.

1995-01-01

A detailed review of recent developments in Reynolds stress modeling for incompressible turbulent shear flows is provided. The mathematical foundations of both two-equation models and full second-order closures are explored in depth. It is shown how these models can be systematically derived for two-dimensional mean turbulent flows that are close to equilibrium. A variety of examples are provided to demonstrate how well properly calibrated versions of these models perform for such flows. However, substantial problems remain for the description of more complex turbulent flows where there are large departures from equilibrium. Recent efforts to extend Reynolds stress models to nonequilibrium turbulent flows are discussed briefly along with the major modeling issues relevant to practical naval hydrodynamics applications.

Mathematics and the surgeon.

PubMed Central

Crank, J.

1976-01-01

The surgeon uses elementary mathematics just as much as any other educated layman. In his professional life, however, much of the knowledge and skill on which he relies has had a mathematical strand in its development, possibly woven into the supporting disciplines such as physics, chemistry, biology, and bioengineering. The valves and limitations of mathematical models are examined briefly in the general medical field and particularly in relation to the surgeon. Arithmetic and statistics are usually regarded as the most immediately useful parts of mathematics. Examples are cited, however, of medical postgraduate work which uses other highly advanced mathematical techniques. The place of mathematics in postgraduate and postexperience teaching courses is touched on. The role of a mathematical consultant in the medical team is discussed. PMID:942167

Nonlinear Acoustics in Ultrasound Metrology and other Selected Applications.

PubMed

Lewin, Peter A

2010-01-01

A succinct background explaining why, initially, both the scientific community and industry were skeptical about the existence of the nonlinear (NL) wave propagation in tissue will be given and the design of an adequately wideband piezoelectric polymer hydrophone probe that was eventually used to verify that the 1-5 MHz probing wave then used in diagnostic ultrasound imaging was undergoing nonlinear distortion and generated harmonics in tissue will be discussed. The far-reaching implications of the advent of the piezoelectric PVDF polymer material will be reviewed and the advances in ultrasound metrology prompted by the regulatory agencies such as US Food and Drug Administration (FDA) and International Electrotechnical Commission (IEC) will be presented. These advances include the development of absolute calibration techniques for hydrophones along with the methods of accounting for spatial averaging corrections up to 100 MHz and the development of "point-receiver" hydrophone probes utilizing acousto-optic sensors. Next, selected therapeutic applications of nonlinear ultrasonics (NLU), including lithotripters will be briefly discussed. Also, the use of shock waves as pain relief tool and in abating penicillin resistant bacteria that develop rock hard "biofilm" that can be shattered by the finite amplitude wave will also be mentioned. The growing applications of NLU in cosmetic industry where it is used for redistribution and reduction of fatty tissue within the body will be briefly reviewed, and, finally, selected examples of NLU applications in retail and entertainment industry will also be pointed out.

Web GIS in practice X: a Microsoft Kinect natural user interface for Google Earth navigation

PubMed Central

2011-01-01

This paper covers the use of depth sensors such as Microsoft Kinect and ASUS Xtion to provide a natural user interface (NUI) for controlling 3-D (three-dimensional) virtual globes such as Google Earth (including its Street View mode), Bing Maps 3D, and NASA World Wind. The paper introduces the Microsoft Kinect device, briefly describing how it works (the underlying technology by PrimeSense), as well as its market uptake and application potential beyond its original intended purpose as a home entertainment and video game controller. The different software drivers available for connecting the Kinect device to a PC (Personal Computer) are also covered, and their comparative pros and cons briefly discussed. We survey a number of approaches and application examples for controlling 3-D virtual globes using the Kinect sensor, then describe Kinoogle, a Kinect interface for natural interaction with Google Earth, developed by students at Texas A&M University. Readers interested in trying out the application on their own hardware can download a Zip archive (included with the manuscript as additional files 1, 2, &3) that contains a 'Kinnogle installation package for Windows PCs'. Finally, we discuss some usability aspects of Kinoogle and similar NUIs for controlling 3-D virtual globes (including possible future improvements), and propose a number of unique, practical 'use scenarios' where such NUIs could prove useful in navigating a 3-D virtual globe, compared to conventional mouse/3-D mouse and keyboard-based interfaces. PMID:21791054

Adaptive Treatment Strategies in Youth Mental Health: A Commentary on Advantages, Challenges, and Potential Directions.

PubMed

Sherrill, Joel T

2016-01-01

This commentary underscores the importance and potential of the research approaches and intervention strategies described in the JCCAP special issue on the Science of Adaptive Treatment Strategies in Child and Adolescent Mental Health for addressing the widely observed heterogeneity in response to even our most promising research-informed interventions. First, the commentary briefly summarizes the advantages of these approaches and highlights how these programs of research are responsive to widely agreed-upon calls for more personalized, prescriptive interventions. Next, the commentary briefly discusses key common challenges and gaps in our knowledge that might be addressed to advance the development, testing, and implementation of adaptive intervention strategies. For example, research to identify robust moderators that might serve as potential tailoring variables for initial assignment and sequencing of interventions, efforts to operationalize surrogate endpoints for early identification of individuals who are unlikely to respond to first-line interventions, and research that helps define what constitutes an adequate exposure (i.e., dose) or response threshold (e.g., response that suggests the need to intensify, switch, or augment interventions) would inform decision rules for adaptive algorithms. The commentary concludes with a discussion of potential strategies and current initiatives that might ultimately help facilitate research on more targeted, prescriptive approaches to intervening, including efforts to encourage investigators to use common data elements, to share and integrate data across trials, and to employ a more mechanism-based approach to intervention development and testing.

Web GIS in practice X: a Microsoft Kinect natural user interface for Google Earth navigation.

PubMed

Boulos, Maged N Kamel; Blanchard, Bryan J; Walker, Cory; Montero, Julio; Tripathy, Aalap; Gutierrez-Osuna, Ricardo

2011-07-26

This paper covers the use of depth sensors such as Microsoft Kinect and ASUS Xtion to provide a natural user interface (NUI) for controlling 3-D (three-dimensional) virtual globes such as Google Earth (including its Street View mode), Bing Maps 3D, and NASA World Wind. The paper introduces the Microsoft Kinect device, briefly describing how it works (the underlying technology by PrimeSense), as well as its market uptake and application potential beyond its original intended purpose as a home entertainment and video game controller. The different software drivers available for connecting the Kinect device to a PC (Personal Computer) are also covered, and their comparative pros and cons briefly discussed. We survey a number of approaches and application examples for controlling 3-D virtual globes using the Kinect sensor, then describe Kinoogle, a Kinect interface for natural interaction with Google Earth, developed by students at Texas A&M University. Readers interested in trying out the application on their own hardware can download a Zip archive (included with the manuscript as additional files 1, 2, &3) that contains a 'Kinnogle installation package for Windows PCs'. Finally, we discuss some usability aspects of Kinoogle and similar NUIs for controlling 3-D virtual globes (including possible future improvements), and propose a number of unique, practical 'use scenarios' where such NUIs could prove useful in navigating a 3-D virtual globe, compared to conventional mouse/3-D mouse and keyboard-based interfaces.

Nonlinear acoustics in ultrasound metrology and other selected applications

NASA Astrophysics Data System (ADS)

Lewin, Peter A.

2010-01-01

A succinct background explaining why, initially, both the scientific community and industry were skeptical about the existence of the nonlinear (NL) wave propagation in tissue will be given and the design of an adequately wideband piezoelectric polymer hydrophone probe that was eventually used to verify that the 1-5 MHz probing wave then used in diagnostic ultrasound imaging was undergoing nonlinear distortion and generated harmonics in tissue will be discussed. The far-reaching implications of the advent of the piezoelectric PVDF polymer material will be reviewed and the advances in ultrasound metrology prompted by the regulatory agencies such as US Food and Drug Administration (FDA) and International Electrotechnical Commission (IEC) will be presented. These advances include the development of absolute calibration techniques for hydrophones along with the methods of accounting for spatial averaging corrections up to 100 MHz and the development of 'point-receiver' hydrophone probes utilizing acousto-optic sensors. Next, selected therapeutic applications of nonlinear ultrasonics (NLU), including lithotripters will be briefly discussed. Also, the use of shock waves as pain relief tool and in abating penicillin resistant bacteria that develop rock hard 'biofilm' that can be shattered by the finite amplitude wave will also be mentioned. The growing applications of NLU in cosmetic industry where it is used for redistribution and reduction of fatty tissue within the body will be briefly reviewed, and, finally, selected examples of NLU applications in retail and entertainment industry will also be pointed out.

Laboratory Identification of Arthropod Ectoparasites

PubMed Central

Pritt, Bobbi S.

2014-01-01

SUMMARY The collection, handling, identification, and reporting of ectoparasitic arthropods in clinical and reference diagnostic laboratories are discussed in this review. Included are data on ticks, mites, lice, fleas, myiasis-causing flies, and bed bugs. The public health importance of these organisms is briefly discussed. The focus is on the morphological identification and proper handling and reporting of cases involving arthropod ectoparasites, particularly those encountered in the United States. Other arthropods and other organisms not of public health concern, but routinely submitted to laboratories for identification, are also briefly discussed. PMID:24396136

The use and misuse of electronic patient data.

PubMed

Brent, Nancy J

2005-01-01

This article highlights patient privacy rights, briefly discusses a few of the many federal, state, and local regulatory laws protecting patient confidentiality and privacy electronically, and briefly reviews several case decisions in this area. Implications for infusion nurses also are presented.

The rules of information aggregation and emergence of collective intelligent behavior.

PubMed

Bettencourt, Luís M A

2009-10-01

Information is a peculiar quantity. Unlike matter and energy, which are conserved by the laws of physics, the aggregation of knowledge from many sources can in fact produce more information (synergy) or less (redundancy) than the sum of its parts. This feature can endow groups with problem-solving strategies that are superior to those possible among noninteracting individuals and, in turn, may provide a selection drive toward collective cooperation and coordination. Here we explore the formal properties of information aggregation as a general principle for explaining features of social organization. We quantify information in terms of the general formalism of information theory, which also prescribes the rules of how different pieces of evidence inform the solution of a given problem. We then show how several canonical examples of collective cognition and coordination can be understood through principles of minimization of uncertainty (maximization of predictability) under information pooling over many individuals. We discuss in some detail how collective coordination in swarms, markets, natural language processing, and collaborative filtering may be guided by the optimal aggregation of information in social collectives. We also identify circumstances when these processes fail, leading, for example, to inefficient markets. The contrast to approaches to understand coordination and collaboration via decision and game theory is also briefly discussed. Copyright © 2009 Cognitive Science Society, Inc.

Hyperbolic and semi-parametric models in finance

NASA Astrophysics Data System (ADS)

Bingham, N. H.; Kiesel, Rüdiger

2001-02-01

The benchmark Black-Scholes-Merton model of mathematical finance is parametric, based on the normal/Gaussian distribution. Its principal parametric competitor, the hyperbolic model of Barndorff-Nielsen, Eberlein and others, is briefly discussed. Our main theme is the use of semi-parametric models, incorporating the mean vector and covariance matrix as in the Markowitz approach, plus a non-parametric part, a scalar function incorporating features such as tail-decay. Implementation is also briefly discussed.

Educational Scholarship and Technology: Resources for a Changing Undergraduate Medical Education Curriculum.

PubMed

Kyle, Brandon N; Corral, Irma; John, Nadyah Janine; Shelton, P G

2017-06-01

Returning to the original emphasis of higher education, universities have increasingly recognized the value and scholarship of teaching, and medical schools have been part of this educational scholarship movement. At the same time, the preferred learning styles of a new generation of medical students and advancements in technology have driven a need to incorporate technology into psychiatry undergraduate medical education (UGME). Educators need to understand how to find, access, and utilize such educational technology. This article provides a brief historical context for the return to education as scholarship, along with a discussion of some of the advantages to this approach, as well as several recent examples. Next, the educational needs of the current generation of medical students, particularly their preference to have technology incorporated into their education, will be discussed. Following this, we briefly review the educational scholarship of two newer approaches to psychiatry UGME that incorporate technology. We also offer the reader some resources for accessing up-to-date educational scholarship for psychiatry UGME, many of which take advantage of technology themselves. We conclude by discussing the need for promotion of educational scholarship.

Encapsulins: microbial nanocompartments with applications in biomedicine, nanobiotechnology and materials science.

PubMed

Giessen, Tobias W

2016-10-01

Compartmentalization is one of the defining features of life. Cells use protein compartments to exert spatial control over their metabolism, store nutrients and create unique microenvironments needed for essential physiological processes. Encapsulins are a recently discovered class of protein nanocompartments found in bacteria and archaea that naturally encapsulate cargo proteins. A short C-terminal targeting sequence directs the highly specific encapsulation process in vivo. Here, I will initially discuss the properties, diversity and putative function of encapsulins. The unique characteristics and potential uses of the self-sorting cargo-packaging process found in encapsulin systems will then be highlighted. Examples for the application of encapsulins as cell-specific optical nanoprobes and targeted therapeutic delivery systems will be discussed with an emphasis on the ability to integrate multiple functionalities within a single nanodevice. By fusing targeting sequences to non-native proteins, encapsulins can also be used as specific nanocontainers and enzymatic nanoreactors in vivo. I will end by briefly discussing future avenues for encapsulin research related to both basic microbial metabolism and applications in biomedicine, catalysis and materials science. Copyright © 2016 Elsevier Ltd. All rights reserved.

Using AppletMagic(tm) to Implement an Orbit Propagator: New Life for Ada Objects

NASA Technical Reports Server (NTRS)

Stark, Michael E.

1997-01-01

This paper will discuss the use of the Intermetrics AppletMagic tool to build an applet to display a satellite ground track on a world map. This applet is the result of a prototype project that was developed by the Goddard Space Flight Center's Flight Dynamics Division (FDD), starting in June of 1996. Both Version 1 and Version 2 of this applet can be accessed via the URL http://fdd.gsfc.nasa.gov/Java.html. This paper covers Version 1, as Version 2 did not make radical changes to the Ada part of the applet. This paper will briefly describe the design of the applet, discuss the issues that arose during development, and will conclude with lessons learned and future plans for the FDD's use of Ada and Java. The purpose of this paper is to show examples of a successful project using Oi AppletMagic, and to highlight some of the pitfalls that occurred along the way. It is hoped that this discussion will be useful both to users of AppletMagic and to organizations such as Intermetrics that develop new technology.

MIRO: A debugging tool for CLIPS incorporating historical Rete networks

NASA Technical Reports Server (NTRS)

Tuttle, Sharon M.; Eick, Christoph F.

1994-01-01

At the last CLIPS conference, we discussed our ideas for adding a temporal dimension to the Rete network used to implement CLIPS. The resulting historical Rete network could then be used to store 'historical' information about a run of a CLIPS program, to aid in debugging. MIRO, a debugging tool for CLIPS built on top of CLIPS, incorporates such a historical Rete network and uses it to support its prototype question-answering capability. By enabling CLIPS users to directly ask debugging-related questions about the history of a program run, we hope to reduce the amount of single-stepping and program tracing required to debug a CLIPS program. In this paper, we briefly describe MIRO's architecture and implementation, and the current question-types that MIRO supports. These question-types are further illustrated using an example, and the benefits of the debugging tool are discussed. We also present empirical results that measure the run-time and partial storage overhead of MIRO, and discuss how MIRO may also be used to study various efficiency aspects of CLIPS programs.

ROMUSE 2.0 User Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khuwaileh, Bassam; Turinsky, Paul; Williams, Brian J.

2016-10-04

ROMUSE (Reduced Order Modeling Based Uncertainty/Sensitivity Estimator) is an effort within the Consortium for Advanced Simulation of Light water reactors (CASL) to provide an analysis tool to be used in conjunction with reactor core simulators, especially the Virtual Environment for Reactor Applications (VERA). ROMUSE is written in C++ and is currently capable of performing various types of parameters perturbations, uncertainty quantification, surrogate models construction and subspace analysis. Version 2.0 has the capability to interface with DAKOTA which gives ROMUSE access to the various algorithms implemented within DAKOTA. ROMUSE is mainly designed to interface with VERA and the Comprehensive Modeling andmore » Simulation Suite for Nuclear Safety Analysis and Design (SCALE) [1,2,3], however, ROMUSE can interface with any general model (e.g. python and matlab) with Input/Output (I/O) format that follows the Hierarchical Data Format 5 (HDF5). In this brief user manual, the use of ROMUSE will be overviewed and example problems will be presented and briefly discussed. The algorithms provided here range from algorithms inspired by those discussed in Ref.[4] to nuclear-specific algorithms discussed in Ref. [3].« less

Technology Options for Libraries. ERIC Digest.

ERIC Educational Resources Information Center

Schamber, Linda

This two-page digest briefly outlines some of the technological trends in updating a library, and briefly discusses the administrative issues and strategies involved. It begins by describing the wholly integrated information environment, which would include: (1) public-access personal and professional communications networks; (2) information…

Challenges of Human-Robot Communication in Telerobotics

NASA Technical Reports Server (NTRS)

Bejczy, Antal K.

1996-01-01

Some general considerations are presented on bilateral human-telerobot control and information communication issues. Advances are reviewed related to the more conventional human-telerobot communication techniques, and some unconventional but promising communication methods are briefly discussed. Future needs and emerging application domains are briefly indicated.

Open Ambient Intelligence Environments.

PubMed

Burzagli, Laura; Emiliani, Pier Luigi

2015-01-01

The present impact of ambient intelligence concepts in eInclusion is first briefly reviewed. Suggestions and examples of how ambient intelligent environments should be specified, designed and used to favour independent living of people with activity limitations are presented.

2D-dynamic representation of DNA sequences as a graphical tool in bioinformatics

NASA Astrophysics Data System (ADS)

Bielińska-Wa̧Ż, D.; Wa̧Ż, P.

2016-10-01

2D-dynamic representation of DNA sequences is briefly reviewed. Some new examples of 2D-dynamic graphs which are the graphical tool of the method are shown. Using the examples of the complete genome sequences of the Zika virus it is shown that the present method can be applied for the study of the evolution of viral genomes.

Approaches to Aggregation and Decision Making-A Health Economics Approach: An ISPOR Special Task Force Report [5].

PubMed

Phelps, Charles E; Lakdawalla, Darius N; Basu, Anirban; Drummond, Michael F; Towse, Adrian; Danzon, Patricia M

2018-02-01

The fifth section of our Special Task Force report identifies and discusses two aggregation issues: 1) aggregation of cost and benefit information across individuals to a population level for benefit plan decision making and 2) combining multiple elements of value into a single value metric for individuals. First, we argue that additional elements could be included in measures of value, but such elements have not generally been included in measures of quality-adjusted life-years. For example, we describe a recently developed extended cost-effectiveness analysis (ECEA) that provides a good example of how to use a broader concept of utility. ECEA adds two features-measures of financial risk protection and income distributional consequences. We then discuss a further option for expanding this approach-augmented CEA, which can introduce many value measures. Neither of these approaches, however, provide a comprehensive measure of value. To resolve this issue, we review a technique called multicriteria decision analysis that can provide a comprehensive measure of value. We then discuss budget-setting and prioritization using multicriteria decision analysis, issues not yet fully resolved. Next, we discuss deliberative processes, which represent another important approach for population- or plan-level decisions used by many health technology assessment bodies. These use quantitative information on CEA and other elements, but the group decisions are reached by a deliberative voting process. Finally, we briefly discuss the use of stated preference methods for developing "hedonic" value frameworks, and conclude with some recommendations in this area. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Hydrothermal Growth of Polyscale Crystals

NASA Astrophysics Data System (ADS)

Byrappa, Kullaiah

In this chapter, the importance of the hydrothermal technique for growth of polyscale crystals is discussed with reference to its efficiency in synthesizing high-quality crystals of various sizes for modern technological applications. The historical development of the hydrothermal technique is briefly discussed, to show its evolution over time. Also some of the important types of apparatus used in routine hydrothermal research, including the continuous production of nanosize crystals, are discussed. The latest trends in the hydrothermal growth of crystals, such as thermodynamic modeling and understanding of the solution chemistry, are elucidated with appropriate examples. The growth of some selected bulk, fine, and nanosized crystals of current technological significance, such as quartz, aluminum and gallium berlinites, calcite, gemstones, rare-earth vanadates, electroceramic titanates, and carbon polymorphs, is discussed in detail. Future trends in the hydrothermal technique, required to meet the challenges of fast-growing demand for materials in various technological fields, are described. At the end of this chapter, an Appendix 18.A containing a more or less complete list of the characteristic families of crystals synthesized by the hydrothermal technique is given with the solvent and pressure-temperature (PT) conditions used in their synthesis.

Issues in the design of a pilot concept-based query interface for the neuroinformatics information framework.

PubMed

Marenco, Luis; Li, Yuli; Martone, Maryann E; Sternberg, Paul W; Shepherd, Gordon M; Miller, Perry L

2008-09-01

This paper describes a pilot query interface that has been constructed to help us explore a "concept-based" approach for searching the Neuroscience Information Framework (NIF). The query interface is concept-based in the sense that the search terms submitted through the interface are selected from a standardized vocabulary of terms (concepts) that are structured in the form of an ontology. The NIF contains three primary resources: the NIF Resource Registry, the NIF Document Archive, and the NIF Database Mediator. These NIF resources are very different in their nature and therefore pose challenges when designing a single interface from which searches can be automatically launched against all three resources simultaneously. The paper first discusses briefly several background issues involving the use of standardized biomedical vocabularies in biomedical information retrieval, and then presents a detailed example that illustrates how the pilot concept-based query interface operates. The paper concludes by discussing certain lessons learned in the development of the current version of the interface.

Earth’s gravity and the cosmological constant: a worked example

NASA Astrophysics Data System (ADS)

Pereira, J. A. M.

2016-03-01

The cosmological constant regained the attention of the scientific community following the recent discovery of the accelerated expansion of the Universe. Consequently, interest in the subject increased amongst the public such that it now often appears in the classroom and popular science publications. The purpose of this article is to use basic concepts of Newtonian mechanics, like dynamics, kinetic energy and potential energy diagrams, in a scenario where the cosmological constant’s action, considered as being an inertial force driven by the accelerated expansion of the Universe, could counteract Earth’s gravity. The effect that the cosmological constant might have near the Earth’s surface is discussed showing how everyday life would change. This is done in such a way that makes it accessible to students in their first year of college. Finally, the modern interpretation of the cosmological constant, associated with the existence of dark energy, is briefly discussed along with upper limit estimations for its value based on the anthropic principle.

Catalytic hydroprocessing of heavy oil feedstocks

NASA Astrophysics Data System (ADS)

Okunev, A. G.; Parkhomchuk, E. V.; Lysikov, A. I.; Parunin, P. D.; Semeikina, V. S.; Parmon, V. N.

2015-09-01

A grave problem of modern oil refining industry is continuous deterioration of the produced oil quality, on the one hand, and increase in the demand for motor fuels, on the other hand. This necessitates processing of heavy oil feedstock with high contents of sulfur, nitrogen and metals and the atmospheric residue. This feedstock is converted to light oil products via hydrogenation processes catalyzed by transition metal compounds, first of all, cobalt- or nickel-promoted molybdenum and tungsten compounds. The processing involves desulfurization, denitrogenation and demetallization reactions as well as reactions converting heavy hydrocarbons to lighter fuel components. The review discusses the mechanisms of reactions involved in the heavy feedstock hydroprocessing, the presumed structure and state of the catalytically active components and methods for the formation of supports with the desired texture. Practically used and prospective approaches to catalytic upgrading of heavy oil feedstock as well as examples of industrial processing of bitumen and vacuum residues in the presence of catalysts are briefly discussed. The bibliography includes 140 references.

Revisiting global body politics in Nepal: A reflexive analysis.

PubMed

Harcourt, Wendy

2016-01-01

Using the example of a human rights training in Nepal, the author looks at global body politics in a reflexive piece on her engagement in development practices that translate western feminist ideas on gender inequality and empowerment via UN human rights policies into non-western contexts. It firsts look at postcolonial and critical literature on feminist engagement in gender and development processes including a discussion on the concept of global body politics before examining briefly the framing of gender-based violence in Nepal. The core of the paper is a reflexive analysis and interrogation of the training in Nepal in order to bring out the tensions and contradictions around western developmental, feminist and human rights discourses. The discussion looks at how difficult it is for feminist, human rights and developmental discourses and practices to unmoor themselves from the notion of the 'expert' and those who do the rights/work/righting rights training and those who are perennially seen as requiring training. The conclusion reflects on possibilities of other epistemic practices found in intercultural dialogues.

Unfolding story of inclusion-body myositis and myopathies: role of misfolded proteins, amyloid-beta, cholesterol, and aging.

PubMed

Askanas, Valerie; Engel, W King

2003-03-01

Sporadic inclusion-body myositis and hereditary inclusion-body myopathies are progressive muscle diseases leading to severe disability. We briefly summarize their clinical pictures and pathologic diagnostic criteria and discuss the latest advances in illuminating their pathogenic mechanism(s). We emphasize how different etiologies might lead to the strikingly similar pathology and possibly similar pathogenic cascade. On the basis of our research, several processes seem to be important in relation to the still speculative pathogenesis, including (a) increased transcription and accumulation of amyloid-beta precursor protein and accumulation of its proteolytic fragment amyloid-beta; (b) abnormal accumulation of components related to lipid metabolism, for example, cholesterol, accumulation of which is possibly owing to its abnormal trafficking; (c) oxidative stress; (d) accumulations of other Alzheimer's disease-related proteins; and (e) a milieu of muscle cellular aging in which these changes occur. We discuss a potentially very important role of unfolded and/or misfolded proteins as a possible mechanism in the formations of the inclusion bodies and other abnormalities.

Discovering Socio-cultural Aspects of Science Through Artworks

NASA Astrophysics Data System (ADS)

Güney, Burcu Gülay; Şeker, Hayati

2017-11-01

Scientific literacy is one of the primary purposes of science education which briefly focuses on using and interpreting scientific explanations, understanding science within its culture. However, science curricula emphasize science with its cognitive aspects and underestimate affective and aesthetic aspects of science. Science education needs to cover beauty of science for students to cross borders between their own culture and culture of science and to achieve the aim of scientific literacy. Relating aesthetic aspects of science with content of science and paving the way for aesthetic experiences through artworks may enrich science education. The purposes of this study are to discuss the need of integrating aesthetic aspects of science in science instruction and to propose examples and pedagogical suggestions to promote aesthetic experiences into the science education. Artworks are selected to present socio-cultural aspects of science to demonstrate the culture of science, their stories are explained, and pedagogical suggestions are proposed. Advantages and difficulties of using artworks in science instruction are discussed as a result of the study.

Winds, Mountains, and Wildland Fire: Improved Understanding of Coupled Atmosphere-Topography-Fire Interactions Through Large-Eddy Simulation

NASA Astrophysics Data System (ADS)

Munoz-Esparza, D.; Sauer, J.; Linn, R.

2015-12-01

Anomalous and unexpected fire behavior in complex terrain continues to result in substantial loss of property and extremely dangerous conditions for firefighting field personnel. We briefly discuss proposed hypotheses of fire interactions with atmospheric flows over complex terrain that can lead to poorly-understood and potentially catastrophic scenarios. Then, our recent results of numerical investigations via large-eddy simulation of coupled atmosphere-topography-fire phenomenology with the Los Alamos National Laboratory, HiGrad-Firetec model are presented as an example of the potential for increased understanding of these complex processes. This investigation focuses on the influence of downslope surface wind enhancement through stably stratified flow over an isolated hill, and the resulting dramatic changes in fire behavior including spread rate, and intensity. Implications with respect to counter-intuitive fire behavior and extreme fire events are discussed. This work demonstrates a tremendous opportunity to immediately create safer and more effective policy for field personnel through improved predictability of atmospheric conditions over complex terrain

Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms☆

PubMed Central

Mori, Takaharu; Miyashita, Naoyuki; Im, Wonpil; Feig, Michael; Sugita, Yuji

2016-01-01

This paper reviews various enhanced conformational sampling methods and explicit/implicit solvent/membrane models, as well as their recent applications to the exploration of the structure and dynamics of membranes and membrane proteins. Molecular dynamics simulations have become an essential tool to investigate biological problems, and their success relies on proper molecular models together with efficient conformational sampling methods. The implicit representation of solvent/membrane environments is reasonable approximation to the explicit all-atom models, considering the balance between computational cost and simulation accuracy. Implicit models can be easily combined with replica-exchange molecular dynamics methods to explore a wider conformational space of a protein. Other molecular models and enhanced conformational sampling methods are also briefly discussed. As application examples, we introduce recent simulation studies of glycophorin A, phospholamban, amyloid precursor protein, and mixed lipid bilayers and discuss the accuracy and efficiency of each simulation model and method. This article is part of a Special Issue entitled: Membrane Proteins. Guest Editors: J.C. Gumbart and Sergei Noskov. PMID:26766517

Issues in the Design of a Pilot Concept-Based Query Interface for the Neuroinformatics Information Framework

PubMed Central

Li, Yuli; Martone, Maryann E.; Sternberg, Paul W.; Shepherd, Gordon M.; Miller, Perry L.

2009-01-01

This paper describes a pilot query interface that has been constructed to help us explore a “concept-based” approach for searching the Neuroscience Information Framework (NIF). The query interface is concept-based in the sense that the search terms submitted through the interface are selected from a standardized vocabulary of terms (concepts) that are structured in the form of an ontology. The NIF contains three primary resources: the NIF Resource Registry, the NIF Document Archive, and the NIF Database Mediator. These NIF resources are very different in their nature and therefore pose challenges when designing a single interface from which searches can be automatically launched against all three resources simultaneously. The paper first discusses briefly several background issues involving the use of standardized biomedical vocabularies in biomedical information retrieval, and then presents a detailed example that illustrates how the pilot concept-based query interface operates. The paper concludes by discussing certain lessons learned in the development of the current version of the interface. PMID:18953674

An introduction to autonomous control systems

NASA Technical Reports Server (NTRS)

Antsaklis, Panos J.; Passino, Kevin M.; Wang, S. J.

1991-01-01

The functions, characteristics, and benefits of autonomous control are outlined. An autonomous control functional architecture for future space vehicles that incorporates the concepts and characteristics described is presented. The controller is hierarchical, with an execution level (the lowest level), coordination level (middle level), and management and organization level (highest level). The general characteristics of the overall architecture, including those of the three levels, are explained, and an example to illustrate their functions is given. Mathematical models for autonomous systems, including 'logical' discrete event system models, are discussed. An approach to the quantitative, systematic modeling, analysis, and design of autonomous controllers is also discussed. It is a hybrid approach since it uses conventional analysis techniques based on difference and differential equations and new techniques for the analysis of the systems described with a symbolic formalism such as finite automata. Some recent results from the areas of planning and expert systems, machine learning, artificial neural networks, and the area restructurable controls are briefly outlined.

The ethics of Foucault and Ricoeur: an underrepresented discussion in nursing.

PubMed

Flaming, Don

2006-09-01

Paul Ricoeur and Michel Foucault enjoy a privileged status in nursing academia as two thinkers who influence both nursing research and philosophical explorations of nursing practice. Most nurse authors, however, focus only on the earlier works of these two philosophers and, for example, base qualitative research methodologies on Foucault's genealogy and Ricoeur's hermeneutics. In their later years, both these writers talk more explicitly about being an ethical self. Ideas from their earlier writing is evident in their writing on ethics and both writers could not discuss ethics without also exploring their ideas of the self and the other. I suggest that some of their thoughts on ethics connect with or complement each other quite well. I will first give an overview of Foucault's ethics, self and the other, and then do the same with Ricoeur's thought. In the third part of the paper I will describe how Foucault and Ricoeur complement each other, and conclude the paper by briefly suggesting how these writers influence my own practice as a nurse educator.

Characterizing millisecond intermediates in hemoproteins using rapid-freeze-quench resonance Raman spectroscopy.

PubMed

Matsumura, Hirotoshi; Moënne-Loccoz, Pierre

2014-01-01

The combination of rapid freeze quenching (RFQ) with resonance Raman (RR) spectroscopy represents a unique tool with which to investigate the nature of short-lived intermediates formed during the enzymatic reactions of metalloproteins. Commercially available equipment allows trapping of intermediates within a millisecond to second time scale for low-temperature RR analysis resulting in the direct detection of metal-ligand vibrations and porphyrin skeletal vibrations in hemoproteins. This chapter briefly discusses RFQ-RR studies carried out previously in our laboratory and presents, as a practical example, protocols for the preparation of RFQ samples of the reaction of metmyoglobin with nitric oxide (NO) under anaerobic conditions. Also described are important controls and practical procedures for the analysis of these samples by low-temperature RR spectroscopy.

Autonomic innervation of the fish gut.

PubMed

Olsson, Catharina

2009-01-01

The enteric nervous system follows a similar overall arrangement in all vertebrate groups. In fish, the majority of nerve cell bodies are found in the myenteric plexus, innervating muscles, blood vessels and glands. In this review, I describe similarities and differences in size, shape and transmitter content in enteric neurons in different fish species and also in comparison with other vertebrates, foremost mammals. The use of different histological and immunochemical methods is reviewed in a historical perspective including advantages and disadvantages of different methods. Lately, zebrafish have become an important model species for developmental studies of the nervous system, including the enteric nervous system, and this is briefly discussed. Finally, examples of how the enteric nervous system controls gut activity in fish is presented, focussing on the effect on gastrointestinal motility.

Micropatterning strategies to engineer controlled cell and tissue architecture in vitro.

PubMed

D'Arcangelo, Elisa; McGuigan, Alison P

2015-01-01

Micropatterning strategies, which enable control over cell and tissue architecture in vitro, have emerged as powerful platforms for modelling tissue microenvironments at different scales and complexities. Here, we provide an overview of popular micropatterning techniques, along with detailed descriptions, to guide new users through the decision making process of which micropatterning procedure to use, and how to best obtain desired tissue patterns. Example techniques and the types of biological observations that can be made are provided from the literature. A focus is placed on microcontact printing to obtain co-cultures of patterned, confluent sheets, and the challenges associated with optimizing this protocol. Many issues associated with microcontact printing, however, are relevant to all micropatterning methodologies. Finally, we briefly discuss challenges in addressing key limitations associated with current micropatterning technologies.

Solid state microdosimetry.

PubMed

Bradley, P D; Rosenfeld, A B; Zaider, M

2001-09-01

A review of solid state microdosimetry is presented with an emphasis on silicon-based devices. The historical foundations and basics of microdosimetry are briefly provided. Various methods of experimental regional microdosimetry are discussed to facilitate a comparison with the more recent development of silicon microdosimetry. In particular, the performance characteristics of a proportional gas counter and a silicon microdosimeter are compared. Recent improvements in silicon microdosimetry address the issues of requirement specification, non-spherical shape, tissue equivalence, sensitive volume definition (charge collection complexity) and low noise requirements which have previously impeded the implementation of silicon-based microdosimetry. A prototype based on silicon-on-insulator technology is described along with some example results from clinical high LET radiotherapy facilities. A brief summary of the applications of microdosimetry is included. c2001 Elsevier Science B.V. All rights reserved.

Guidelines for using electronic and social media: the regulatory perspective.

PubMed

Spector, Nancy; Kappel, Dawn M

2012-09-30

Social media can be a very effective way of communicating in nursing, but guidelines for appropriate use by healthcare providers are essential. This article briefly introduces the phenomenon of social media and introduces three actual scenarios where nurses unintentionally violated appropriate use of social media in healthcare. The scenarios are discussed related to social media, career, concerns, and nursing regulation. Incorporating these and other examples with data from board of nursing cases, the nature of complaints against nurses is explored as well as common myths and misunderstandings about using social media platforms. Guidelines for appropriate use by nurses and available resources to inform policy are highlighted. Next steps in social media in nursing should include development of organizational level policies and educational programs on the use of social media.

Brief review of emerging photovoltaic absorbers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zakutayev, Andriy

Photovoltaic solar cells have recently made significant commercial progress and are on track toward meeting more than 1% of global energy demand. However, further research is needed on photovoltaic technologies that face no scalability constraints in generating more than 10% of the world's electricity. This 2017 article briefly reviews emerging photovoltaic absorber materials, focusing on research progress over the past 2-3 years. Particular emphasis is given to emerging solar cell absorbers -- for example, SnS, Sb 2Se 3, Cu 2SnS 3, and CuSbSe 2 -- related to established solar cell technologies such as CdTe, Cu(In,Ga)Se 2, and CH 3NH 3PbImore » 3. Lastly, the general publication and performance trends are discussed, and the promising future research directions are pointed out.« less

LACIE - A look to the future. [Large Area Crop Inventory Experiment

NASA Technical Reports Server (NTRS)

Macdonald, R. B.; Hall, F. G.

1977-01-01

The Large Area Crop Inventory Experiment (LACIE) is a 'proof of concept' project designed to demonstrate the applicability of remote sensing technology to the global monitoring of wheat. This paper discusses the need for more timely and reliable monitoring of food and fiber supplies, reviews the monitoring systems currently utilized by the USDA and United Nations Food and Agriculture Organization in the United States and in foreign countries, and elucidates the fundamentals involved in assessing the impact of variable weather and economic conditions on wheat acreage, yield, and production. The experiment's approach to production monitoring is described briefly, and its status is reviewed as of the conclusion of 2 years of successful operation. Examples of acreage and yield monitoring in the Soviet Union are used to illustrate the experiment's approach.

[Hazard function and life table: an introduction to the failure time analysis].

PubMed

Matsushita, K; Inaba, H

1987-04-01

Failure time analysis has become popular in demographic studies. It can be viewed as a part of regression analysis with limited dependent variables as well as a special case of event history analysis and multistate demography. The idea of hazard function and failure time analysis, however, has not been properly introduced to nor commonly discussed by demographers in Japan. The concept of hazard function in comparison with life tables is briefly described, where the force of mortality is interchangeable with the hazard rate. The basic idea of failure time analysis is summarized for the cases of exponential distribution, normal distribution, and proportional hazard models. The multiple decrement life table is also introduced as an example of lifetime data analysis with cause-specific hazard rates.

In vivo microscopy of the mouse brain using multiphoton laser scanning techniques

NASA Astrophysics Data System (ADS)

Yoder, Elizabeth J.

2002-06-01

The use of multiphoton microscopy for imaging mouse brain in vivo offers several advantages and poses several challenges. This tutorial begins by briefly comparing multiphoton microscopy with other imaging modalities used to visualize the brain and its activity. Next, an overview of the techniques for introducing fluorescence into whole animals to generate contrast for in vivo microscopy using two-photon excitation is presented. Two different schemes of surgically preparing mice for brain imaging with multiphoton microscopy are reviewed. Then, several issues and problems with in vivo microscopy - including motion artifact, respiratory and cardiac rhythms, maintenance of animal health, anesthesia, and the use of fiducial markers - are discussed. Finally, examples of how these techniques have been applied to visualize the cerebral vasculature and its response to hypercapnic stimulation are provided.

Rare earth fluoride nano-/microstructures: hydrothermal synthesis, luminescent properties and applications.

PubMed

Zhao, Qian; Xu, Zhenhe; Sun, Yaguang

2014-02-01

Rare earth fluoride materials have attracted wide interest and come to the forefront in nanophotonics due to their distinct electrical, optical and magnetic properties as well as their potential applications in diverse fields such as optical telecommunication, lasers, biochemical probes, infrared quantum counters, and medical diagnostics. This review presents a comprehensive overview of the flourishing field of rare earth fluorides materials in the past decade. We summarize the recent research progress on the preparation, morphology, luminescent properties and application of rare earth fluoride-based luminescent materials by hydrothermal systems. Various rare earth fluoride materials are obtained by fine-tuning of experimental conditions, such as capping agents, fluoride source, acidity, temperature and reaction time. The controlled morphology, luminescent properties and application of the rare earth fluorides are briefly discussed with typical examples.

Classical calculation of the equilibrium constants for true bound dimers using complete potential energy surface.

PubMed

Buryak, Ilya; Vigasin, Andrey A

2015-12-21

The present paper aims at deriving classical expressions which permit calculation of the equilibrium constant for weakly interacting molecular pairs using a complete multidimensional potential energy surface. The latter is often available nowadays as a result of the more and more sophisticated and accurate ab initio calculations. The water dimer formation is considered as an example. It is shown that even in case of a rather strongly bound dimer the suggested expression permits obtaining quite reliable estimate for the equilibrium constant. The reliability of our obtained water dimer equilibrium constant is briefly discussed by comparison with the available data based on experimental observations, quantum calculations, and the use of RRHO approximation, provided the latter is restricted to formation of true bound states only.

Classical calculation of the equilibrium constants for true bound dimers using complete potential energy surface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buryak, Ilya; Vigasin, Andrey A., E-mail: vigasin@ifaran.ru

The present paper aims at deriving classical expressions which permit calculation of the equilibrium constant for weakly interacting molecular pairs using a complete multidimensional potential energy surface. The latter is often available nowadays as a result of the more and more sophisticated and accurate ab initio calculations. The water dimer formation is considered as an example. It is shown that even in case of a rather strongly bound dimer the suggested expression permits obtaining quite reliable estimate for the equilibrium constant. The reliability of our obtained water dimer equilibrium constant is briefly discussed by comparison with the available data basedmore » on experimental observations, quantum calculations, and the use of RRHO approximation, provided the latter is restricted to formation of true bound states only.« less

Frontier Research in Astrophysics: The State of Art

NASA Astrophysics Data System (ADS)

Giovannelli, F.; Sabau-Graziati, L.

2016-12-01

This article is a summary of the updated version of the review article "The impact of the space experiments on our knowledge of the physics of the Universe" (Giovannelli & Sabau-Graziati, 2004) and subsequent updating (Giovannelli & Sabau-Graziati, 2012a, 2015a). We will go along different stages of the evolution of our Universe discussing briefly several examples of results that, in accordance with our opinion, are the pillars carrying the Bridge between the Big Bang and Biology. A part significant of these results come from great experiments in Earth or from space. Similarly, small experiments on Earth or in space have provided - and will provide - significant results. Due to the limited extension of this work and according to our knowledge, we have made a strict selection of the topics.

Brief review of emerging photovoltaic absorbers

DOE PAGES

Zakutayev, Andriy

2017-02-08

Photovoltaic solar cells have recently made significant commercial progress and are on track toward meeting more than 1% of global energy demand. However, further research is needed on photovoltaic technologies that face no scalability constraints in generating more than 10% of the world's electricity. This 2017 article briefly reviews emerging photovoltaic absorber materials, focusing on research progress over the past 2-3 years. Particular emphasis is given to emerging solar cell absorbers -- for example, SnS, Sb 2Se 3, Cu 2SnS 3, and CuSbSe 2 -- related to established solar cell technologies such as CdTe, Cu(In,Ga)Se 2, and CH 3NH 3PbImore » 3. Lastly, the general publication and performance trends are discussed, and the promising future research directions are pointed out.« less

Getting ready for petaflop capacities and beyond: a utility perspective

NASA Astrophysics Data System (ADS)

Hamelin, J. F.; Berthou, J. Y.

2008-07-01

Why should EDF, the leading producer and marketer of electricity in Europe, start adding teraflops to its terawatt-hours and become involved in high-performance computing (HPC)? In this paper we answer this question through examples of major opportunities that HPC brings to our business today and, we hope well into the future of petaflop and exaflop computing. Five cases are presented dealing with nondestructive testing, nuclear fuel management, mechanical behavior of nuclear fuel assemblies, water management, and energy management. For each case we show the benefits brought by HPC, describe the current level of numerical simulation performance, and discuss the perspectives for future steps. We also present the general background that explains why EDF is moving to this technology and briefly comment on the development of user-oriented simulation platforms.

From Giza to the Pantheon: astronomy as a key to the architectural projects of the ancient past

NASA Astrophysics Data System (ADS)

Magli, Giulio

2011-06-01

In many of the ``wonders'' of our past, information about their meaning and scope has been encoded in the form of astronomical alignments to celestial bodies. Therefore, in many cases, understanding the ideas of the ancient architects turns out to be connected with the study of the relationship of their cultures with the sky. This is the aim of archaeoastronomy, a discipline which is a quite efficacious tool in unraveling the original projects of many monuments. This issue is briefly discussed here by means of three examples taken from three completely different cultures and historical periods: the so-called ``air shafts'' of the Great Pyramid, the urban layout of the capital of the Incas, and the design of the Pantheon.

Effective Interpersonal Communication: A Practical Guide to Improve Your Life.

PubMed

Vertino, Kathleen A

2014-09-30

Use of effective interpersonal communication strategies by nurses in both personal and professional settings, may reduce stress, promote wellness, and therefore, improve overall quality of life. This article briefly explores the concept of interpersonal communication as it relates to Maslow's hierarchy of human needs; describes personal variables and the interaction of internal and external variables that can impact communication; and discusses possible causes and consequences of ineffective communication. Drawing on both the literature and experiences as a longtime provider of care in the mental health field, the author offers multiple practical strategies, with specific examples of possible responses for effective communication. Recommendations in this article are intended for nurses to consider as they seek healthy communication strategies that may be useful in both their personal and professional lives.

Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexandrov, S; Subhash, H; Leahy, M

2014-07-31

We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach is based on spectral encoding of spatial frequency. Information about the spatial structure is directly translated from the Fourier domain to the image domain as different wavelengths, without compromising the accuracy. Axial spatial period profiles of the structure are reconstructed for any volume of interest within the 3D OCT image with nanoscale sensitivity. An example of application of the nanoscale OCT to probe the internal structure ofmore » medico-biological objects, the anterior chamber of an ex vivo rat eye, is demonstrated. (laser biophotonics)« less

A fully Galerkin method for the recovery of stiffness and damping parameters in Euler-Bernoulli beam models

NASA Technical Reports Server (NTRS)

Smith, R. C.; Bowers, K. L.

1991-01-01

A fully Sinc-Galerkin method for recovering the spatially varying stiffness and damping parameters in Euler-Bernoulli beam models is presented. The forward problems are discretized with a sinc basis in both the spatial and temporal domains thus yielding an approximate solution which converges exponentially and is valid on the infinite time interval. Hence the method avoids the time-stepping which is characteristic of many of the forward schemes which are used in parameter recovery algorithms. Tikhonov regularization is used to stabilize the resulting inverse problem, and the L-curve method for determining an appropriate value of the regularization parameter is briefly discussed. Numerical examples are given which demonstrate the applicability of the method for both individual and simultaneous recovery of the material parameters.

Moral Education in Time of Global Transformation

ERIC Educational Resources Information Center

Clarken, Rodney H.

2006-01-01

Conceptions of morality and moral education are in need of reexamination in this time of global transformation. Historical views of morality and moral education are briefly presented, the commonalities and implications of these conceptualizations discussed and their influence on civilization briefly explored. The modern-day conceptions of morality…

Our Impact on Earth

NASA Astrophysics Data System (ADS)

Warren, A.

This paper discusses the problem of understanding the causes of changes in the Earth's environments. It reviews very briefly the role of the atmosphere, because it is an important element of the total picture. It discusses even more briefly the oceans, and then the land, moving from the wetter parts to the drier ones, these last being the writer's speciality as a desert geomorphologist. No apology is made for concentrating on the terrestrial deserts, for Mars is more like our deserts than any other part of Earth.

Review of problems in application of supersonic combustion

NASA Technical Reports Server (NTRS)

Ferri, A.

1977-01-01

The problem of air-breathing engines capable of flying at very high Mach numbers is described briefly. Possible performance of supersonic combustion ramjets is outlined briefly and the supersonic combustion process is described. Two mechanisms of combustion are outlined: one is supersonic combustion controlled by convection process, and the second is controlled by diffusion. The parameters related to the combustion process are discussed in detail. Data and analyses of reaction rates and mixing phenomena are represented; the flame mechanism is discussed, and experimental results are presented.

Office Sexism--Women Against Themselves

ERIC Educational Resources Information Center

Tillar, Darrel Long; Maidment, Robert

1978-01-01

The existence of discrimination toward women managers by other women is examined briefly, with examples of attitudes and office situations cited. Suggestions are offered for an effective manager to minimize the potential nonproductivity caused by women against themselves. (LBH)

Ayudele! [Help Him!].

ERIC Educational Resources Information Center

Spencer, Maria Gutierrez, Comp.; Almance, Sofia, Comp.

Written in Spanish and English, the booklet briefly discusses what parents can do to help their child learn at school. The booklet briefly notes the importance of getting enough sleep; eating breakfast; praising the child; developing the five senses; visiting the doctor; having a home and garden; talking, listening, and reading to the child;…

Information Foraging in Nuclear Power Plant Control Rooms

DOE Office of Scientific and Technical Information (OSTI.GOV)

R.L. Boring

2011-09-01

nformation foraging theory articulates the role of the human as an 'informavore' that seeks information and follows optimal foraging strategies (i.e., the 'information scent') to find meaningful information. This paper briefly reviews the findings from information foraging theory outside the nuclear domain and then discusses the types of information foraging strategies operators employ for normal and off-normal operations in the control room. For example, operators may employ a predatory 'wolf' strategy of hunting for information in the face of a plant upset. However, during routine operations, the operators may employ a trapping 'spider' strategy of waiting for relevant indicators tomore » appear. This delineation corresponds to information pull and push strategies, respectively. No studies have been conducted to determine explicitly the characteristics of a control room interface that is optimized for both push and pull information foraging strategies, nor has there been empirical work to validate operator performance when transitioning between push and pull strategies. This paper explores examples of control room operators as wolves vs. spiders and con- cludes by proposing a set of research questions to investigate information foraging in control room settings.« less

Decoupling Polymer Properties to Elucidate Mechanisms Governing Cell Behavior

PubMed Central

Wang, Xintong; Boire, Timothy C.; Bronikowski, Christine; Zachman, Angela L.; Crowder, Spencer W.

2012-01-01

Determining how a biomaterial interacts with cells (“structure-function relationship”) reflects its eventual clinical applicability. Therefore, a fundamental understanding of how individual material properties modulate cell-biomaterial interactions is pivotal to improving the efficacy and safety of clinically translatable biomaterial systems. However, due to the coupled nature of material properties, their individual effects on cellular responses are difficult to understand. Structure-function relationships can be more clearly understood by the effective decoupling of each individual parameter. In this article, we discuss three basic decoupling strategies: (1) surface modification, (2) cross-linking, and (3) combinatorial approaches (i.e., copolymerization and polymer blending). Relevant examples of coupled material properties are briefly reviewed in each section to highlight the need for improved decoupling methods. This follows with examples of more effective decoupling techniques, mainly from the perspective of three primary classes of synthetic materials: polyesters, polyethylene glycol, and polyacrylamide. Recent strides in decoupling methodologies, especially surface-patterning and combinatorial techniques, offer much promise in further understanding the structure-function relationships that largely govern the success of future advancements in biomaterials, tissue engineering, and drug delivery. PMID:22536977

Rare and unusual ... or are they? Less commonly diagnosed encephalopathies associated with systemic disease.

PubMed

Weathers, Allison L; Lewis, Steven L

2009-04-01

Encephalopathy due to hepatic or renal failure, electrolyte disturbances, or the administration of benzodiazepines and narcotics is commonly encountered, well reviewed in the literature, and, therefore, not usually missed. This article focuses on encephalopathies that were previously well described but may be overlooked by modern clinicians, as well as those that are still taught in the classroom but seldom thought of in practice. Due to the presumed relative rarity of these cases and emphasis on the well-memorized "classic" clinical presentations, these often treatable, and perhaps not so rare, encephalopathies due to systemic medical illness may go undiagnosed and untreated. Pancreatic encephalopathy, Wernicke's encephalopathy, and pellagra encephalopathy are reviewed in detail; cefepime and ifosfamide encephalopathies are discussed as examples of specific medication-induced encephalopathies. Septic encephalopathy, central pontine myelinolysis, and fat embolism syndrome are briefly reviewed. The encephalopathies reviewed have the potential for devastating neurological consequences if recognition and, therefore, treatment are delayed. Clinical improvement for many of these syndromes depends on prompt intervention. This article highlights some representative examples of less-commonly diagnosed metabolic and toxic encephalopathies.

Cross-field diffusion in Hall thrusters and other plasma thrusters

NASA Astrophysics Data System (ADS)

Boeuf, J. P.

2012-10-01

Understanding and quantifying electron transport perpendicular to the magnetic field is a challenge in many low temperature plasma applications. Hall effect thrusters (HETs) provide an excellent example of cross-field transport. The HET is a very successful concept that can be considered both as a gridless ion source and an electromagnetic thruster. In HETs, the electric field E accelerating the ions is a consequence of the Lorentz force due to an external magnetic field B acting on the ExB Hall electron current. An essential aspect of HETs is that the ExB drift is closed, i.e. is in the azimuthal direction of a cylindrical channel. In the first part of this presentation we will discuss the physics of cross-field electron transport in HETs, and the current understanding (or non-understanding) of the possible role of turbulence and wall collisions on cross-field diffusion. We will also briefly comment on alternative designs of ion sources based on the same principles as the conventional HET (Anode Layer Thruster, Diverging Cusp Field Thrusters, End-Hall ion sources). In a second part of the presentation we show that the Lorentz force acting on diamagnetic currents (associated with the ∇PexB term in the electron momentum equation) can also provide thrust. This is the case for example in helicon thrusters where the plasma expands in a magnetic nozzle. We will report and discuss recent work on helicon thrusters and other devices where the diamagnetic current is dominant (with some examples where the ∇PexB current is not closed and is directed toward a wall!).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bank, A.; Anderson, W.F.; Zaino, E.C.

This book discusses the topics presented at the symposium on the subject of 'Thalassemia'. Sickle cell anemia is also briefly discussed. The aspects discussed are chromosomal defects of anemias particularly globin synthesis, and the role of messenger RNA and other chromosomes.

Science Update: Analytical Chemistry.

ERIC Educational Resources Information Center

Worthy, Ward

1980-01-01

Briefly discusses new instrumentation in the field of analytical chemistry. Advances in liquid chromatography, photoacoustic spectroscopy, the use of lasers, and mass spectrometry are also discussed. (CS)

Text-based Analytics for Biosurveillance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charles, Lauren E.; Smith, William P.; Rounds, Jeremiah

The ability to prevent, mitigate, or control a biological threat depends on how quickly the threat is identified and characterized. Ensuring the timely delivery of data and analytics is an essential aspect of providing adequate situational awareness in the face of a disease outbreak. This chapter outlines an analytic pipeline for supporting an advanced early warning system that can integrate multiple data sources and provide situational awareness of potential and occurring disease situations. The pipeline, includes real-time automated data analysis founded on natural language processing (NLP), semantic concept matching, and machine learning techniques, to enrich content with metadata related tomore » biosurveillance. Online news articles are presented as an example use case for the pipeline, but the processes can be generalized to any textual data. In this chapter, the mechanics of a streaming pipeline are briefly discussed as well as the major steps required to provide targeted situational awareness. The text-based analytic pipeline includes various processing steps as well as identifying article relevance to biosurveillance (e.g., relevance algorithm) and article feature extraction (who, what, where, why, how, and when). The ability to prevent, mitigate, or control a biological threat depends on how quickly the threat is identified and characterized. Ensuring the timely delivery of data and analytics is an essential aspect of providing adequate situational awareness in the face of a disease outbreak. This chapter outlines an analytic pipeline for supporting an advanced early warning system that can integrate multiple data sources and provide situational awareness of potential and occurring disease situations. The pipeline, includes real-time automated data analysis founded on natural language processing (NLP), semantic concept matching, and machine learning techniques, to enrich content with metadata related to biosurveillance. Online news articles are presented as an example use case for the pipeline, but the processes can be generalized to any textual data. In this chapter, the mechanics of a streaming pipeline are briefly discussed as well as the major steps required to provide targeted situational awareness. The text-based analytic pipeline includes various processing steps as well as identifying article relevance to biosurveillance (e.g., relevance algorithm) and article feature extraction (who, what, where, why, how, and when).« less

Shot and bead peening control

NASA Astrophysics Data System (ADS)

John, R.

The merits of the peening effect in improving the fatigue resistance of ferrous and non-ferrous media is discussed. The machines that perform the peening task are also discussed, including the rotating-wheel plant, pressure-type air-assisted peening machines, and suction systems. The peening process itself is discussed briefly, and an outline of the parameters that affect the product specification is presented. The merits of the Almen test strip as a measure of correct treatment are evaluated, and the two types of devices are discussed for monitoring the flow of peening media. The two types of feed control devices (one for ferrous media and the other for non-ferrous media) for accurately controlling the feed of peening media are also briefly examined.

Electric moisture meters for wood

Treesearch

William L. James

1963-01-01

Common methods of measuring the moisture content of wood are described briefly, and a short historical account of the development of electric moisture meters is given. Electrical properties of wood are discussed briefly, and the basic operation of the resistance type and the radio- frequency types of moisture meter is outlined. Data relating the electrical resistance...

Mexico: Rasgos de Su Historia. (Mexico: Highlights of Its History).

ERIC Educational Resources Information Center

Orozco, Cecilio

Intended for both teachers and students, this publication, written in Spanish, briefly traces Mexico's history from its Conquest in 1519 to the overthrow of Porfirio Diaz in 1910. The following are briefly discussed: Mexico's Conquest in 1519; events immediately after the fall of Tenochtitlan; the War for Independence; Texas' separation from…

Entanglement in General Multipartite Quantum Systems and Its Role in Quantum Information Processing Tasks

NASA Astrophysics Data System (ADS)

Gielerak, Roman

A major role playing by entanglement of quantum states in several, present day applications of genuine quantum technologies is briefly reviewed. Additionally, the notion and classification of multipartite entanglement has been presented. A new, monotone under (S)LOCC-operations measures of many-partite entanglement are defined and discussed briefly.

Public Noneconomic Benefits of Higher Education. Working Draft.

ERIC Educational Resources Information Center

Marien, Michael

The purpose of this memorandum is to outline and briefly discuss a variety of public non-economic effects of higher education--i.e., social benefits and costs that do not involve specifically economic concerns. Appendix A briefly summarizes the data on private non-economic benefits, or the social consequences to the individual of attending college…

Real-time neutron imaging of gas turbines

NASA Astrophysics Data System (ADS)

Stewart, P. A. E.

1987-06-01

The current status of real-time neutron radiography imaging is briefly reviewed, and results of tests carried out on cold neutron sources are reported. In particular, attention is given to demonstrations of neutron radiography on a running gas turbine engine. The future role of real-time neutron imaging in engineering diagnostics is briefly discussed.

Advanced solid-state NMR spectroscopy of natural organic matter.

PubMed

Mao, Jingdong; Cao, Xiaoyan; Olk, Dan C; Chu, Wenying; Schmidt-Rohr, Klaus

2017-05-01

Solid-state NMR is essential for the characterization of natural organic matter (NOM) and is gaining importance in geosciences and environmental sciences. This review is intended to highlight advanced solid-state NMR techniques, especially a systematic approach to NOM characterization, and their applications to the study of NOM. We discuss some basics of how to acquire high-quality and quantitative solid-state 13 C NMR spectra, and address some common technical mistakes that lead to unreliable spectra of NOM. The identification of specific functional groups in NOM, primarily based on 13 C spectral-editing techniques, is described and the theoretical background of some recently-developed spectral-editing techniques is provided. Applications of solid-state NMR to investigating nitrogen (N) in NOM are described, focusing on limitations of the widely used 15 N CP/MAS experiment and the potential of improved advanced NMR techniques for characterizing N forms in NOM. Then techniques used for identifying proximities, heterogeneities and domains are reviewed, and some examples provided. In addition, NMR techniques for studying segmental dynamics in NOM are reviewed. We also briefly discuss applications of solid-state NMR to NOM from various sources, including soil organic matter, aquatic organic matter, organic matter in atmospheric particulate matter, carbonaceous meteoritic organic matter, and fossil fuels. Finally, examples of NMR-based structural models and an outlook are provided. Copyright © 2016 Elsevier B.V. All rights reserved.

Singing Strings.

ERIC Educational Resources Information Center

Riveire, Janine

1996-01-01

Recommends singing as an instructional strategy for string and other instrument classes. Maintains that singing familiarizes the student with the music and can serve as an illustrative example of musical techniques. Includes a list of tonal objectives found in repertory songs. Briefly reviews several instructional texts. (MJP)

Broken detailed balance and non-equilibrium dynamics in living systems: a review

NASA Astrophysics Data System (ADS)

Gnesotto, F. S.; Mura, F.; Gladrow, J.; Broedersz, C. P.

2018-06-01

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as high-fidelity transcription and translation, sensing, adaptation, biochemical patterning, and force generation. While biological systems such as motor enzymes violate detailed balance at the molecular scale, it remains unclear how non-equilibrium dynamics manifests at the mesoscale in systems that are driven through the collective activity of many motors. Indeed, in several cellular systems the presence of non-equilibrium dynamics is not always evident at large scales. For example, in the cytoskeleton or in chromosomes one can observe stationary stochastic processes that appear at first glance thermally driven. This raises the question how non-equilibrium fluctuations can be discerned from thermal noise. We discuss approaches that have recently been developed to address this question, including methods based on measuring the extent to which the system violates the fluctuation-dissipation theorem. We also review applications of this approach to reconstituted cytoskeletal networks, the cytoplasm of living cells, and cell membranes. Furthermore, we discuss a more recent approach to detect actively driven dynamics, which is based on inferring broken detailed balance. This constitutes a non-invasive method that uses time-lapse microscopy data, and can be applied to a broad range of systems in cells and tissue. We discuss the ideas underlying this method and its application to several examples including flagella, primary cilia, and cytoskeletal networks. Finally, we briefly discuss recent developments in stochastic thermodynamics and non-equilibrium statistical mechanics, which offer new perspectives to understand the physics of living systems.

Broken detailed balance and non-equilibrium dynamics in living systems: a review.

PubMed

Gnesotto, F S; Mura, F; Gladrow, J; Broedersz, C P

2018-06-01

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as high-fidelity transcription and translation, sensing, adaptation, biochemical patterning, and force generation. While biological systems such as motor enzymes violate detailed balance at the molecular scale, it remains unclear how non-equilibrium dynamics manifests at the mesoscale in systems that are driven through the collective activity of many motors. Indeed, in several cellular systems the presence of non-equilibrium dynamics is not always evident at large scales. For example, in the cytoskeleton or in chromosomes one can observe stationary stochastic processes that appear at first glance thermally driven. This raises the question how non-equilibrium fluctuations can be discerned from thermal noise. We discuss approaches that have recently been developed to address this question, including methods based on measuring the extent to which the system violates the fluctuation-dissipation theorem. We also review applications of this approach to reconstituted cytoskeletal networks, the cytoplasm of living cells, and cell membranes. Furthermore, we discuss a more recent approach to detect actively driven dynamics, which is based on inferring broken detailed balance. This constitutes a non-invasive method that uses time-lapse microscopy data, and can be applied to a broad range of systems in cells and tissue. We discuss the ideas underlying this method and its application to several examples including flagella, primary cilia, and cytoskeletal networks. Finally, we briefly discuss recent developments in stochastic thermodynamics and non-equilibrium statistical mechanics, which offer new perspectives to understand the physics of living systems.

Archetypes, Causal Description and Creativity in Natural World

NASA Astrophysics Data System (ADS)

Chiatti, Leonardo

The idea, formulated for the first time by Pauli, of a "creativity" of natural processes on a quantum scale is briefly investigated, with particular reference to the phenomena, common throughout the biological world, involved in the amplification of microscopic "creative" events at oscopic level. The involvement of non-locality is also discussed with reference to the synordering of events, a concept introduced for the first time by Bohm. Some convergences are proposed between the metamorphic process envisaged by Bohm and that envisaged by Goethe, and some possible applications concerning known biological phenomena are briefly discussed.

Identification, rearing, and distribution of stick insects of Madeira Island: An example of raising biodiversity awareness

PubMed Central

Aguiar, António M. F.; Pombo, Dora Aguin; Gonçalves, Ysabel M.

2014-01-01

Abstract Two species of stick insects are currently known to be present in the Macaronesian archipelagos: Clonopsis gallica (Charpentier) (Phasmatodea: Bacillidae) on the Canary Islands and in the Azores and Carausius morosus (Sinéty) (Phasmatidae) in the Azores. Here, we provide the first reliable records of the presence and distribution of C. gallica and C. morosus on Madeira Island. Egg and adult stages are briefly described along with some notes on the life history of these species in captivity. Data on islandwide distribution are based on specimens donated by the public in response to an article published in a daily newspaper. This method of data collection raised great popular interest in stick insects. The role of newspapers as a means of communicating awareness in biodiversity issues is discussed. PMID:25373196

The Role of Project Science in the Chandra X-Ray Observatory

NASA Technical Reports Server (NTRS)

O'Dell, Stephen L.; Weisskopf, Martin C.

2006-01-01

The Chandra X-Ray Observatory, one of NASA's Great Observatories, has an outstanding record of scientific and technical success. This success results from the efforts of a team comprising NASA, its contractors, the Smithsonian Astrophysical Observatory, the instrument groups, and other elements of the scientific community, including thousands of scientists who utilize this powerful facility for astrophysical research. We discuss the role of NASA Project Science in the formulation, development, calibration, and operation of the Chandra X-ray Observatory. In addition to representing the scientific community within the Project, Project Science performed what we term "science systems engineering". This activity encompasses translation of science requirements into technical requirements and assessment of the scientific impact of programmatic and technical trades. We briefly describe several examples of science systems engineering conducted by Chandra Project Science.

Human genetic technology: who shall control?

PubMed

Blank, R H

1984-01-01

The biotechnical "revolution" has fast come upon us. It promises to produce both substantial benefits and difficult dilemmas for individuals and society. Despite the growing attention being paid to biotechnology, a major unanswered question is who shall control the development and use of the powerful array of human genetic and reproductive innovations. Should the decisions be left to individual consumers and private industry or should they be made by the government or other social institutions? After briefly reviewing development in human genetics and reproduction and describing trends toward commercialization of them, this article discusses the dilemmas these trends raise for a democratic society. It argues for the urgent need to delineate societal goals and priorities for the future and for technology assessment as early as possible in the developmental process. The article concludes by presenting some examples of the social policy problems now emerging.

Storing free magnetic energy in the solar corona

NASA Astrophysics Data System (ADS)

Vekstein, G.

2016-08-01

This article presents a mini-tutorial aimed at a wide readership not familiar with the field of solar plasma physics. The exposition is centred around the issue of excess/free magnetic energy stored in the solar corona. A general consideration is followed with a particular example of coronal magnetic arcade, where free magnetic energy builds up by photospheric convective flows. In the context of solar physics the major task is to explain how this free energy can be released quickly enough to match what is observed in coronal explosive events such as solar flares. Therefore, in the last section of the paper we discuss briefly a possible role of magnetic reconnection in these processes. This is done in quite simple qualitative physical terms, so that an interested reader can follow it up in more detail with help of the provided references.

Sinc-Galerkin estimation of diffusivity in parabolic problems

NASA Technical Reports Server (NTRS)

Smith, Ralph C.; Bowers, Kenneth L.

1991-01-01

A fully Sinc-Galerkin method for the numerical recovery of spatially varying diffusion coefficients in linear partial differential equations is presented. Because the parameter recovery problems are inherently ill-posed, an output error criterion in conjunction with Tikhonov regularization is used to formulate them as infinite-dimensional minimization problems. The forward problems are discretized with a sinc basis in both the spatial and temporal domains thus yielding an approximate solution which displays an exponential convergence rate and is valid on the infinite time interval. The minimization problems are then solved via a quasi-Newton/trust region algorithm. The L-curve technique for determining an approximate value of the regularization parameter is briefly discussed, and numerical examples are given which show the applicability of the method both for problems with noise-free data as well as for those whose data contains white noise.

Approximation methods for inverse problems involving the vibration of beams with tip bodies

NASA Technical Reports Server (NTRS)

Rosen, I. G.

1984-01-01

Two cubic spline based approximation schemes for the estimation of structural parameters associated with the transverse vibration of flexible beams with tip appendages are outlined. The identification problem is formulated as a least squares fit to data subject to the system dynamics which are given by a hybrid system of coupled ordinary and partial differential equations. The first approximation scheme is based upon an abstract semigroup formulation of the state equation while a weak/variational form is the basis for the second. Cubic spline based subspaces together with a Rayleigh-Ritz-Galerkin approach were used to construct sequences of easily solved finite dimensional approximating identification problems. Convergence results are briefly discussed and a numerical example demonstrating the feasibility of the schemes and exhibiting their relative performance for purposes of comparison is provided.

Next Generation Sequencing Technology and Genomewide Data Analysis: Perspectives for Retinal Research

PubMed Central

Chaitankar, Vijender; Karakülah, Gökhan; Ratnapriya, Rinki; Giuste, Felipe O.; Brooks, Matthew J.; Swaroop, Anand

2016-01-01

The advent of high throughput next generation sequencing (NGS) has accelerated the pace of discovery of disease-associated genetic variants and genomewide profiling of expressed sequences and epigenetic marks, thereby permitting systems-based analyses of ocular development and disease. Rapid evolution of NGS and associated methodologies presents significant challenges in acquisition, management, and analysis of large data sets and for extracting biologically or clinically relevant information. Here we illustrate the basic design of commonly used NGS-based methods, specifically whole exome sequencing, transcriptome, and epigenome profiling, and provide recommendations for data analyses. We briefly discuss systems biology approaches for integrating multiple data sets to elucidate gene regulatory or disease networks. While we provide examples from the retina, the NGS guidelines reviewed here are applicable to other tissues/cell types as well. PMID:27297499

Evaluation of the constant pressure panel method (CPM) for unsteady air loads prediction

NASA Technical Reports Server (NTRS)

Appa, Kari; Smith, Michael J. C.

1988-01-01

This paper evaluates the capability of the constant pressure panel method (CPM) code to predict unsteady aerodynamic pressures, lift and moment distributions, and generalized forces for general wing-body configurations in supersonic flow. Stability derivatives are computed and correlated for the X-29 and an Oblique Wing Research Aircraft, and a flutter analysis is carried out for a wing wind tunnel test example. Most results are shown to correlate well with test or published data. Although the emphasis of this paper is on evaluation, an improvement in the CPM code's handling of intersecting lifting surfaces is briefly discussed. An attractive feature of the CPM code is that it shares the basic data requirements and computational arrangements of the doublet lattice method. A unified code to predict unsteady subsonic or supersonic airloads is therefore possible.

Topological defects in mixtures of superconducting condensates with different charges

NASA Astrophysics Data System (ADS)

Garaud, Julien; Babaev, Egor

2014-06-01

We investigate the topological defects in phenomenological models describing mixtures of charged condensates with commensurate electric charges. Such situations are expected to appear for example in liquid metallic deuterium. This is modeled by a multicomponent Ginzburg-Landau theory where the condensates are coupled to the same gauge field by different coupling constants whose ratio is a rational number. We also briefly discuss the case where electric charges are incommensurate. Flux quantization and finiteness of the energy per unit length dictate that the different condensates have different winding and thus different number of (fractional) vortices. Competing attractive and repulsive interactions lead to molecule-like bound states between fractional vortices. Such bound states have finite energy and carry integer flux quanta. These can be characterized by the CP1 topological invariant that motivates their denomination as skyrmions.

The chemistry of cyborgs--interfacing technical devices with organisms.

PubMed

Giselbrecht, Stefan; Rapp, Bastian E; Niemeyer, Christof M

2013-12-23

The term "cyborg" refers to a cybernetic organism, which characterizes the chimera of a living organism and a machine. Owing to the widespread application of intracorporeal medical devices, cyborgs are no longer exclusively a subject of science fiction novels, but technically they already exist in our society. In this review, we briefly summarize the development of modern prosthetics and the evolution of brain-machine interfaces, and discuss the latest technical developments of implantable devices, in particular, biocompatible integrated electronics and microfluidics used for communication and control of living organisms. Recent examples of animal cyborgs and their relevance to fundamental and applied biomedical research and bioethics in this novel and exciting field at the crossroads of chemistry, biomedicine, and the engineering sciences are presented. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

HIV models for treatment interruption: Adaptation and comparison

NASA Astrophysics Data System (ADS)

Hillmann, Andreas; Crane, Martin; Ruskin, Heather J.

2017-10-01

In recent years, Antiretroviral Therapy (ART) has become commonplace for treating HIV infections, although a cure remains elusive, given reservoirs of replicating latently-infected cells, which are resistant to normal treatment regimes. Treatment interruptions, whether ad hoc or structured, are known to cause a rapid increase in viral production to detectable levels, but numerous clinical trials remain inconclusive on the dangers inherent in this resurgence. In consequence, interest in examining interruption strategies has recently been rekindled. This overview considers modelling approaches, which have been used to explore the issue of treatment interruption. We highlight their purpose and the formalisms employed and examine ways in which clinical data have been used. Implementation of selected models is demonstrated, illustrative examples provided and model performance compared for these cases. Possible extensions to bottom-up modelling techniques for treatment interruptions are briefly discussed.

NASA aviation safety reporting system

NASA Technical Reports Server (NTRS)

Billings, C. E.; Lauber, J. K.; Funkhouser, H.; Lyman, E. G.; Huff, E. M.

1976-01-01

The origins and development of the NASA Aviation Safety Reporting System (ASRS) are briefly reviewed. The results of the first quarter's activity are summarized and discussed. Examples are given of bulletins describing potential air safety hazards, and the disposition of these bulletins. During the first quarter of operation, the ASRS received 1464 reports; 1407 provided data relevant to air safety. All reports are being processed for entry into the ASRS data base. During the reporting period, 130 alert bulletins describing possible problems in the aviation system were generated and disseminated. Responses were received from FAA and others regarding 108 of the alert bulletins. Action was being taken with respect to 70 of the 108 responses received. Further studies are planned of a number of areas, including human factors problems related to automation of the ground and airborne portions of the national aviation system.

Over 20 years of reaction access systems from MDL: a novel reaction substructure search algorithm.

PubMed

Chen, Lingran; Nourse, James G; Christie, Bradley D; Leland, Burton A; Grier, David L

2002-01-01

From REACCS, to MDL ISIS/Host Reaction Gateway, and most recently to MDL Relational Chemistry Server, a new product based on Oracle data cartridge technology, MDL's reaction database management and retrieval systems have undergone great changes. The evolution of the system architecture is briefly discussed. The evolution of MDL reaction substructure search (RSS) algorithms is detailed. This article mainly describes a novel RSS algorithm. This algorithm is based on a depth-first search approach and is able to fully and prospectively use reaction specific information, such as reacting center and atom-atom mapping (AAM) information. The new algorithm has been used in the recently released MDL Relational Chemistry Server and allows the user to precisely find reaction instances in databases while minimizing unrelated hits. Finally, the existing and new RSS algorithms are compared with several examples.

High-throughput sequencing in veterinary infection biology and diagnostics.

PubMed

Belák, S; Karlsson, O E; Leijon, M; Granberg, F

2013-12-01

Sequencing methods have improved rapidly since the first versions of the Sanger techniques, facilitating the development of very powerful tools for detecting and identifying various pathogens, such as viruses, bacteria and other microbes. The ongoing development of high-throughput sequencing (HTS; also known as next-generation sequencing) technologies has resulted in a dramatic reduction in DNA sequencing costs, making the technology more accessible to the average laboratory. In this White Paper of the World Organisation for Animal Health (OIE) Collaborating Centre for the Biotechnology-based Diagnosis of Infectious Diseases in Veterinary Medicine (Uppsala, Sweden), several approaches and examples of HTS are summarised, and their diagnostic applicability is briefly discussed. Selected future aspects of HTS are outlined, including the need for bioinformatic resources, with a focus on improving the diagnosis and control of infectious diseases in veterinary medicine.

Degradation of Spacecraft Materials in the Space Environment

NASA Technical Reports Server (NTRS)

Miller, Sharon K. R.; Banks, Bruce A.

2010-01-01

When we think of space, we typically think of a vacuum containing very little matter that lies between the Earth and other planetary and stellar bodies. However, the space above Earth's breathable atmosphere and beyond contains many things that make designing durable spacecraft a challenge. Depending on where the spacecraft is flyng, it may encounter atomic oxygen, ultraviolet and other forms of radiation, charged particles, micrormeteoroids and debris, and temperature extremes. These environments on their own and in combination can cause degradation and failure of polymers, composites, paints and other materials used on the exterior of spacecraft for thermal control, structure, and power generation. This article briefly discusses and gives examples of some of the degradation experienced on spacecraft and night experiments as a result of the space environment and the use of ground and space data to predict durability.

Infrared fluorescence from PAHs in the laboratory

NASA Technical Reports Server (NTRS)

Cherchneff, Isabelle; Barker, John R.

1989-01-01

Several celestial objects, including UV rich regions of planetary and reflection nebulae, stars, H II regions, and extragalactic sources, are characterized by the unidentified infrared emission bands (UIR bands). A few years ago, it was proposed that polycyclic aromatic hydrocarbon species (PAHs) are responsible for most of the UIR bands. This hypothesis is based on a spectrum analysis of the observed features. Comparisons of observed IR spectra with lab absorption spectra of PAHs support the PAH hypothesis. An example spectrum is represented, where the Orion Bar 3.3 micron spectrum is compared with the absorption frequencies of the PAHs Chrysene, Pyrene, and Coronene. The laser excited 3.3 micron emission spectrum is presented from a gas phase PAH (azulen). The infrared fluorescence theory (IRF) is briefly explained, followed by a description of the experimental apparatus, a report of the results, and discussion.

Two-dimensional inorganic analogues of graphene: transition metal dichalcogenides.

PubMed

Jana, Manoj K; Rao, C N R

2016-09-13

The discovery of graphene marks a major event in the physics and chemistry of materials. The amazing properties of this two-dimensional (2D) material have prompted research on other 2D layered materials, of which layered transition metal dichalcogenides (TMDCs) are important members. Single-layer and few-layer TMDCs have been synthesized and characterized. They possess a wide range of properties many of which have not been known hitherto. A typical example of such materials is MoS2 In this article, we briefly present various aspects of layered analogues of graphene as exemplified by TMDCs. The discussion includes not only synthesis and characterization, but also various properties and phenomena exhibited by the TMDCs.This article is part of the themed issue 'Fullerenes: past, present and future, celebrating the 30th anniversary of Buckminster Fullerene'. © 2016 The Author(s).

Two-dimensional inorganic analogues of graphene: transition metal dichalcogenides

PubMed Central

Jana, Manoj K.; Rao, C. N. R.

2016-01-01

The discovery of graphene marks a major event in the physics and chemistry of materials. The amazing properties of this two-dimensional (2D) material have prompted research on other 2D layered materials, of which layered transition metal dichalcogenides (TMDCs) are important members. Single-layer and few-layer TMDCs have been synthesized and characterized. They possess a wide range of properties many of which have not been known hitherto. A typical example of such materials is MoS2. In this article, we briefly present various aspects of layered analogues of graphene as exemplified by TMDCs. The discussion includes not only synthesis and characterization, but also various properties and phenomena exhibited by the TMDCs. This article is part of the themed issue ‘Fullerenes: past, present and future, celebrating the 30th anniversary of Buckminster Fullerene’. PMID:27501969

Computer modeling of lung cancer diagnosis-to-treatment process

PubMed Central

Ju, Feng; Lee, Hyo Kyung; Osarogiagbon, Raymond U.; Yu, Xinhua; Faris, Nick

2015-01-01

We introduce an example of a rigorous, quantitative method for quality improvement in lung cancer care-delivery. Computer process modeling methods are introduced for lung cancer diagnosis, staging and treatment selection process. Two types of process modeling techniques, discrete event simulation (DES) and analytical models, are briefly reviewed. Recent developments in DES are outlined and the necessary data and procedures to develop a DES model for lung cancer diagnosis, leading up to surgical treatment process are summarized. The analytical models include both Markov chain model and closed formulas. The Markov chain models with its application in healthcare are introduced and the approach to derive a lung cancer diagnosis process model is presented. Similarly, the procedure to derive closed formulas evaluating the diagnosis process performance is outlined. Finally, the pros and cons of these methods are discussed. PMID:26380181

The Failure of Scientific Medicine: Davis Inlet as an Example of Sociopolitical Morbidity

PubMed Central

Scott, Richard T.; Conn, Selina

1987-01-01

The social and economic history of a Labrador coastal town is reviewed with particular reference to the roles of the Church, the Hudson's Bay Company, and the medical profession. Objective indicators of the current health status of the community are presented, and the major causes of ill-health in Davis Inlet are discussed. Comparison is made with Rudolph Virchow's assessment of the causes of a typhoid epidemic in Upper Silesia in 1848. The subsequent evolution of medicine from a socio-political to a scientific model is reviewed briefly. The authors conclude that the medical profession has embraced the scientific model to the point of virtually excluding the socio-political one, even though social, political, economic, and cultural alienation remain major causes of morbidity and mortality. In so doing, the profession promotes ill-health. PMID:21263779

AVE/VAS 3: 25-mb sounding data

NASA Technical Reports Server (NTRS)

Sienkiewicz, M. E.

1982-01-01

The rawinsonde sounding program for the AVE/VAS 3 experiment is described. Tabulated data are presented at 25-mb intervals for the 24 National Weather Service stations and 14 special stations participating in the experiment. Soundings were taken at 3-hr intervals, beginning at 1200 GMT on March 27, 1982, and ending at 0600 GMT on March 28, 1982 (7 sounding times). An additional sounding was taken at the National Weather Service stations at 1200 GMT on March 28, 1982, at the normal synoptic observation time. The method of processing soundings is briefly discussed, estimates of the RMS errors in the data are presented, and an example of contact data is given. Termination pressures of soundings taken in the mesos-beta-scale network are tabulated, as are observations of ground temperature at a depth of 2 cm.

Cadmium-accumulating plants.

PubMed

Küpper, Hendrik; Leitenmaier, Barbara

2013-01-01

Plants are categorized in three groups concerning their uptake of heavy metals: indicator, excluder, and hyperaccumulator plants, which we explain in this chapter, the former two groups briefly and the hyperaccumulators in detail. The ecological role of hyperaccumulation, for example, the prevention of herbivore attacks and a possible substitution of Zn by Cd in an essential enzyme, is discussed. As the mechanisms of cadmium hyperaccumulation are a very interesting and challenging topic and many aspects are studied worldwide, we provide a broad overview over compartmentation strategies, expression and function of metal transporting proteins and the role of ligands for uptake, transport, and storage of cadmium. Hyperaccumulators are not without reason a topic of great interest, they can be used biotechnologically for two main purposes which we discuss here for Cd: phytoremediation, dealing with the cleaning of anthropogenically contaminated soils as well as phytomining, i.e., the use of plants for commercial metal extraction. Finally, the outlook deals with topics for future research in the fields of biochemistry/biophysics, molecular biology, and biotechnology. We discuss which knowledge is still missing to fully understand Cd hyperaccumulation by plants and to use that phenomenon even more successfully for both environmental and economical purposes.

Drawing Analogies to Deepen Learning

ERIC Educational Resources Information Center

Fava, Michelle

2017-01-01

This article offers examples of how drawing can facilitate thinking skills that promote analogical reasoning to enable deeper learning. The instructional design applies cognitive principles, briefly described here. The workshops were developed iteratively, through feedback from student and teacher participants. Elements of the UK National…

Magical thinking by inpatient staff members.

PubMed

Pilette, W L

1983-01-01

Magical thinking is a primitive form of mental activity which, nevertheless, the author contends, is common among mental health professionals. Four examples of magical thinking by inpatient staff members are presented and briefly explored, in order to shed light on our work and ourselves.

Planning Considerations. Sludge Treatment and Disposal Course #166. Instructor's Guide [and] Student Workbook.

ERIC Educational Resources Information Center

Carnegie, John W.

This lesson deals with special considerations that should be made when choosing a sludge solids management program, briefly describing the source of solids in wastewater and why they must be dealt with. The various solids handling processes and ultimate disposal methods are also briefly described, followed by a detailed discussion of the technical…

About various definitions of life.

PubMed

Luisi, P L

1998-10-01

The old question of a definition of minimal life is taken up again at the aim of providing a forum for an updated discussion. Briefly discussed are the reasons why such an attempt has previously encountered scepticism, and why such an attempt should be renewed at this stage of the inquiry on the origin of life. Then some of the definitions of life presently used are cited and briefly discussed, starting with the definition adopted by NASA as a general working definition. It is shown that this is too limited if one wishes to provide a broad encompassing definition, and some extensions of it are presented and discussed. Finally it is shown how the different definitions of life reflect the main schools of thought that presently dominate the field on the origin of life.

The identification of the variation of atherosclerosis plaques by invasive and non-invasive methods

NASA Technical Reports Server (NTRS)

Selzer, R. H.; Blankenhorn, D. H.

1982-01-01

Computer-enhanced visualization of coronary arteries and lesions within them is discussed, comparing invasive and noninvasive methods. Trial design factors in computer lesions assessment are briefly discussed, and the use of the computer edge-tracking technique in that assessment is described. The results of a small pilot study conducted on serial cineangiograms of men with premature atherosclerosis are presented. A canine study to determine the feasibility of quantifying atherosclerosis from intravenous carotid angiograms is discussed. Comparative error for arterial and venous injection in the canines is determined, and the mode of processing the films to achieve better visualization is described. The application of the computer edge-tracking technique to an ultrasound image of the human carotid artery is also shown and briefly discussed.

Accelerated test program

NASA Technical Reports Server (NTRS)

Ford, F. E.; Harkness, J. M.

1977-01-01

A brief discussion on the accelerated testing of batteries is given. The statistical analysis and the various aspects of the modeling that was done and the results attained from the model are also briefly discussed.

More on homological supersymmetric quantum mechanics

NASA Astrophysics Data System (ADS)

Behtash, Alireza

2018-03-01

In this work, we first solve complex Morse flow equations for the simplest case of a bosonic harmonic oscillator to discuss localization in the context of Picard-Lefschetz theory. We briefly touch on the exact non-BPS solutions of the bosonized supersymmetric quantum mechanics on algebraic geometric grounds and report that their complex phases can be accessed through the cohomology of WKB 1-form of the underlying singular spectral curve subject to necessary cohomological corrections for nonzero genus. Motivated by Picard-Lefschetz theory, we write down a general formula for the index of N =4 quantum mechanics with background R -symmetry gauge fields. We conjecture that certain symmetries of the refined Witten index and singularities of the moduli space may be used to determine the correct intersection coefficients. A few examples, where this conjecture holds, are shown in both linear and closed quivers with rank-one quiver gauge groups. The R -anomaly removal along the "Morsified" relative homology cycles also called "Lefschetz thimbles" is shown to lead to the appearance of Stokes lines. We show that the Fayet-Iliopoulos parameters appear in the intersection coefficients for the relative homology of the quiver quantum mechanics resulting from dimensional reduction of 2 d N =(2 ,2 ) gauge theory on a circle and explicitly calculate integrals along the Lefschetz thimbles in N =4 C Pk -1 model. The Stokes jumping of coefficients and its relation to wall crossing phenomena is briefly discussed. We also find that the notion of "on-the-wall" index is related to the invariant Lefschetz thimbles under Stokes phenomena. An implication of the Lefschetz thimbles in constructing knots from quiver quantum mechanics is indicated.

A Project to Develop Career Awareness Materials for Special Needs Students. Final Report. Research Series No. 19.

ERIC Educational Resources Information Center

Rustan, Jack; And Others

The report briefly describes a project to develop career orientation materials for special needs students--disadvantaged and educable mentally handicapped (EMH)--at the junior and senior high school levels in North Dakota. The activities involved in selecting the career areas are briefly discussed. By polling various students in different parts of…

Strategies to Affect Student Sensory Awareness of the Environment in a Rural Schools Setting: Kindergarten Through Grade Three.

ERIC Educational Resources Information Center

Peters, Richard O.

Presenting eight sample environmental education sensory lessons designed for K-3 students in rural areas, this guide briefly details the rationale and means for developing proximity congruence between students and life space phenomena. Field trips, nature walks, site studies, and other outdoor activities are briefly discussed. The format of each…

NDE for Material Characterization in Aeronautic and Space Applications

NASA Technical Reports Server (NTRS)

Baaklini, George Y.; Kautz, Harold E.; Gyekenyesi, Andrew L.; Abdul-Aziz, Ali; Martin, Richard E.

2000-01-01

This paper describes selected nondestructive evaluation (NDE) approaches that were developed or tailored at the NASA Glenn Research Center for characterizing advanced material systems. The emphasis is on high-temperature aerospace propulsion applications. The material systems include monolithic ceramics, superalloys, and high temperature composites. In the aeronautic area, the highlights are cooled ceramic plate structures for turbine applications, F-TiAl blade materials for low-pressure turbines, thermoelastic stress analysis (TSA) for residual stress measurements in titanium based and nickel based engine materials, and acousto ultrasonics (AU) for creep damage assessment in nickel-based alloys. In the space area, examples consist of cooled carbon-carbon composites for gas generator combustors and flywheel rotors composed of carbon fiber reinforced polymer matrix composites for energy storage on the international space station (ISS). The role of NDE in solving manufacturing problems, the effect of defects on structural behavior, and the use of NDE-based finite element modeling are discussed. NDE technology needs for improved microelectronic and mechanical systems as well as health monitoring of micro-materials and components are briefly discussed.

Tiger LDRD final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steich, D J; Brugger, S T; Kallman, J S

2000-02-01

This final report describes our efforts on the Three-Dimensional Massively Parallel CEM Technologies LDRD project (97-ERD-009). Significant need exists for more advanced time domain computational electromagnetics modeling. Bookkeeping details and modifying inflexible software constitute a vast majority of the effort required to address such needs. The required effort escalates rapidly as problem complexity increases. For example, hybrid meshes requiring hybrid numerics on massively parallel platforms (MPPs). This project attempts to alleviate the above limitations by investigating flexible abstractions for these numerical algorithms on MPPs using object-oriented methods, providing a programming environment insulating physics from bookkeeping. The three major design iterationsmore » during the project, known as TIGER-I to TIGER-III, are discussed. Each version of TIGER is briefly discussed along with lessons learned during the development and implementation. An Application Programming Interface (API) of the object-oriented interface for Tiger-III is included in three appendices. The three appendices contain the Utilities, Entity-Attribute, and Mesh libraries developed during the project. The API libraries represent a snapshot of our latest attempt at insulated the physics from the bookkeeping.« less

Printable Electrochemical Biosensors: A Focus on Screen-Printed Electrodes and Their Application

PubMed Central

Yamanaka, Keiichiro; Vestergaard, Mun’delanji C.; Tamiya, Eiichi

2016-01-01

In this review we present electrochemical biosensor developments, focusing on screen-printed electrodes (SPEs) and their applications. In particular, we discuss how SPEs enable simple integration, and the portability needed for on-field applications. First, we briefly discuss the general concept of biosensors and quickly move on to electrochemical biosensors. Drawing from research undertaken in this area, we cover the development of electrochemical DNA biosensors in great detail. Through specific examples, we describe the fabrication and surface modification of printed electrodes for sensitive and selective detection of targeted DNA sequences, as well as integration with reverse transcription-polymerase chain reaction (RT-PCR). For a more rounded approach, we also touch on electrochemical immunosensors and enzyme-based biosensors. Last, we present some electrochemical devices specifically developed for use with SPEs, including USB-powered compact mini potentiostat. The coupling demonstrates the practical use of printable electrode technologies for application at point-of-use. Although tremendous advances have indeed been made in this area, a few challenges remain. One of the main challenges is application of these technologies for on-field analysis, which involves complicated sample matrices. PMID:27775661

Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms.

PubMed

Mori, Takaharu; Miyashita, Naoyuki; Im, Wonpil; Feig, Michael; Sugita, Yuji

2016-07-01

This paper reviews various enhanced conformational sampling methods and explicit/implicit solvent/membrane models, as well as their recent applications to the exploration of the structure and dynamics of membranes and membrane proteins. Molecular dynamics simulations have become an essential tool to investigate biological problems, and their success relies on proper molecular models together with efficient conformational sampling methods. The implicit representation of solvent/membrane environments is reasonable approximation to the explicit all-atom models, considering the balance between computational cost and simulation accuracy. Implicit models can be easily combined with replica-exchange molecular dynamics methods to explore a wider conformational space of a protein. Other molecular models and enhanced conformational sampling methods are also briefly discussed. As application examples, we introduce recent simulation studies of glycophorin A, phospholamban, amyloid precursor protein, and mixed lipid bilayers and discuss the accuracy and efficiency of each simulation model and method. This article is part of a Special Issue entitled: Membrane Proteins edited by J.C. Gumbart and Sergei Noskov. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges.

PubMed

Yan, Xiaowen; Yang, Limin; Wang, Qiuquan

2013-07-01

Much progress has been made in identification of the proteins in proteomes, and quantification of these proteins has attracted much interest. In addition to popular tandem mass spectrometric methods based on soft ionization, inductively coupled plasma mass spectrometry (ICPMS), a typical example of mass spectrometry based on hard ionization, usually used for analysis of elements, has unique advantages in absolute quantification of proteins by determination of an element with a definite stoichiometry in a protein or attached to the protein. In this Trends article, we briefly describe state-of-the-art ICPMS-based methods for quantification of proteins, emphasizing protein-labeling and element-tagging strategies developed on the basis of chemically selective reactions and/or biospecific interactions. Recent progress from protein to cell quantification by use of ICPMS is also discussed, and the possibilities and challenges of ICPMS-based protein quantification for universal, selective, or targeted quantification of proteins and cells in a biological sample are also discussed critically. We believe ICPMS-based protein quantification will become ever more important in targeted quantitative proteomics and bioanalysis in the near future.

Active control of acoustic pressure fields using smart material technologies

NASA Technical Reports Server (NTRS)

Banks, H. T.; Smith, R. C.

1993-01-01

An overview describing the use of piezoceramic patches in reducing noise in a structural acoustics setting is presented. The passive and active contributions due to patches which are bonded to an Euler-Bernoulli beam or thin shell are briefly discussed and the results are incorporated into a 2-D structural acoustics model. In this model, an exterior noise source causes structural vibrations which in turn lead to interior noise as a result of nonlinear fluid/structure coupling mechanism. Interior sound pressure levels are reduced via patches bonded to the flexible boundary (a beam in this case) which generate pure bending moments when an out-of-phase voltage is applied. Well-posedness results for the infinite dimensional system are discussed and a Galerkin scheme for approximating the system dynamics is outlined. Control is implemented by using linear quadratic regulator (LQR) optimal control theory to calculate gains for the linearized system and then feeding these gains back into the nonlinear system of interest. The effectiveness of this strategy for this problem is illustrated in an example.

Nanocomposites in food packaging applications and their risk assessment for health.

PubMed

Honarvar, Zohreh; Hadian, Zahra; Mashayekh, Morteza

2016-06-01

Nanotechnology has shown many advantages in different fields. As the uses of nanotechnology have progressed, it has been found to be a promising technology for the food packaging industry in the global market. It has proven capabilities that are valuable in packaging foods, including improved barriers; mechanical, thermal, and biodegradable properties; and applications in active and intelligent food packaging. Examples of the latter are anti-microbial agents and nanosensors, respectively. However, the use of nanocomposites in food packaging might be challenging due to the reduced particle size of nanomaterials and the fact that the chemical and physical characteristics of such tiny materials may be quite different from those of their macro-scale counterparts. In order to discuss the potential risks of nanoparticles for consumers, in addition to the quantification of data, a thorough investigation of their characteristics is required. Migration studies must be conducted to determine the amounts of nanomaterials released into the food matrices. In this article, different applications of nanocomposites in food packaging, migration issues, analyzing techniques, and the main concerns about their usage are discussed briefly.

Nanocomposites in food packaging applications and their risk assessment for health

PubMed Central

Honarvar, Zohreh; Hadian, Zahra; Mashayekh, Morteza

2016-01-01

Nanotechnology has shown many advantages in different fields. As the uses of nanotechnology have progressed, it has been found to be a promising technology for the food packaging industry in the global market. It has proven capabilities that are valuable in packaging foods, including improved barriers; mechanical, thermal, and biodegradable properties; and applications in active and intelligent food packaging. Examples of the latter are anti-microbial agents and nanosensors, respectively. However, the use of nanocomposites in food packaging might be challenging due to the reduced particle size of nanomaterials and the fact that the chemical and physical characteristics of such tiny materials may be quite different from those of their macro-scale counterparts. In order to discuss the potential risks of nanoparticles for consumers, in addition to the quantification of data, a thorough investigation of their characteristics is required. Migration studies must be conducted to determine the amounts of nanomaterials released into the food matrices. In this article, different applications of nanocomposites in food packaging, migration issues, analyzing techniques, and the main concerns about their usage are discussed briefly. PMID:27504168

Quantum Landau damping in dipolar Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Mendonça, J. T.; Terças, H.; Gammal, A.

2018-06-01

We consider Landau damping of elementary excitations in Bose-Einstein condensates (BECs) with dipolar interactions. We discuss quantum and quasiclassical regimes of Landau damping. We use a generalized wave-kinetic description of BECs which, apart from the long-range dipolar interactions, also takes into account the quantum fluctuations and the finite-energy corrections to short-range interactions. Such a description is therefore more general than the usual mean-field approximation. The present wave-kinetic approach is well suited for the study of kinetic effects in BECs, such as those associated with Landau damping, atom trapping, and turbulent diffusion. The inclusion of quantum fluctuations and energy corrections changes the dispersion relation and the damping rates, leading to possible experimental signatures of these effects. Quantum Landau damping is described with generality, and particular examples of dipolar condensates in two and three dimensions are studied. The occurrence of roton-maxon excitations, and their relevance to Landau damping, are also considered in detail. The present approach is mainly based on a linear perturbative procedure, but the nonlinear regime of Landau damping, which includes atom trapping and atom diffusion, is also briefly discussed.

Epstein-Barr Virus-Specific Humoral Immune Responses in Health and Disease.

PubMed

Middeldorp, Jaap M

2015-01-01

Epstein-Barr virus (EBV) is widely distributed in the world and associated with a still increasing number of acute, chronic, malignant and autoimmune disease syndromes. Humoral immune responses to EBV have been studied for diagnostic, pathogenic and protective (vaccine) purposes. These studies use a range of methodologies, from cell-based immunofluorescence testing to antibody-diversity analysis using immunoblot and epitope analysis using recombinant or synthetic peptide-scanning. First, the individual EBV antigen complexes (VCA , MA, EA(D), EA(R) and EBNA) are defined at cellular and molecular levels, providing a historic overview. The characteristic antibody responses to these complexes in health and disease are described, and differences are highlighted by clinical examples. Options for EBV vaccination are briefly addressed. For a selected number of immunodominant proteins, in particular EBNA1, the interaction with human antibodies is further detailed at the epitope level, revealing interesting insights for structure, function and immunological aspects, not considered previously. Humoral immune responses against EBV-encoded tumour antigens LMP1, LMP2 and BARF1 are addressed, which provide novel options for targeted immunotherapy. Finally, some considerations on EBV-linked autoimmune diseases are given, and mechanisms of antigen mimicry are briefly discussed. Further analysis of humoral immune responses against EBV in health and disease in carefully selected patient cohorts will open new options for understanding pathogenesis of individual EBV-linked diseases and developing targeted diagnostic and therapeutic approaches.

Quasars, pulsars, black holes and HEAO's

NASA Technical Reports Server (NTRS)

Doolitte, R. F.; Moritz, K.; Whilden, R. D. C.

1974-01-01

Astronomical surveys are discussed by large X-ray, gamma ray, and cosmic ray instruments carried onboard high-energy astronomy observatories. Quasars, pulsars, black holes, and the ultimate benefits of the new astronomy are briefly discussed.

Shopping Mall to Study Hall.

ERIC Educational Resources Information Center

Rittner-Heir, Robbin M.

1999-01-01

Discusses how the Burnsville (Minnesota) expanded its high school classroom space by buying a shopping mall and converting it into classrooms. Renovation costs and classroom layout are briefly discussed; a floor plan is included. (GR)

Digital Simulation in Education.

ERIC Educational Resources Information Center

Braun, Ludwig

Simulation as a mode of computer use in instruction has been neglected by educators. This paper briefly explores the circumstances in which simulations are useful and presents several examples of simulation programs currently being used in high-school biology, chemistry, physics, and social studies classes. One program, STERIL, which simulates…

The Expanding Role of the Atom in the Humanities

ERIC Educational Resources Information Center

Seaborg, Glenn T.

1970-01-01

The techniques of radioactive dating, thermoluminescence dating, cesium magnetometer detecting, x-ray flourescence analysis, and neutron radiography are briefly explained. Examples are given in the use of techniques in determining age and composition of paintings, ceramics, and archeological finds. Included is a history of Lawrence Radiation…

An Optimization Technique for the Development of Two-Dimensional Steady Turbulent Boundary Layer Models.

DTIC Science & Technology

1982-03-01

observed coherent structure of the wall layer flow and will now be briefly described. Over the past decade, it has been well documented (see, for example...D2, and x are all arbitrary constants. Equilibrium flows have been examined experimentally for a number of years and an equilibrium boundary layer...CP93, Paper No. 27, 6. Clauser, F.H. (1954). "Turbulent Boundary Layers in Adverse Pressure Gradients", J. Aeronaut. Sci., 21, pp. 91-108. 7. Clauser

Lie-algebraic Approach to Dynamics of Closed Quantum Systems and Quantum-to-Classical Correspondence

NASA Astrophysics Data System (ADS)

Galitski, Victor

2012-02-01

I will briefly review our recent work on a Lie-algebraic approach to various non-equilibrium quantum-mechanical problems, which has been motivated by continuous experimental advances in the field of cold atoms. First, I will discuss non-equilibrium driven dynamics of a generic closed quantum system. It will be emphasized that mathematically a non-equilibrium Hamiltonian represents a trajectory in a Lie algebra, while the evolution operator is a trajectory in a Lie group generated by the underlying algebra via exponentiation. This turns out to be a constructive statement that establishes, in particular, the fact that classical and quantum unitary evolutions are two sides of the same coin determined uniquely by the same dynamic generators in the group. An equation for these generators - dubbed dual Schr"odinger-Bloch equation - will be derived and analyzed for a few of specific examples. This non-linear equation allows one to construct new exact non-linear solutions to quantum-dynamical systems. An experimentally-relevant example of a family of exact solutions to the many-body Landau-Zener problem will be presented. One practical application of the latter result includes dynamical means to optimize molecular production rate following a quench across the Feshbach resonance.

High-Alpha Handling Qualities Flight Research on the NASA F/A-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Wichman, Keith D.; Pahle, Joseph W.; Bahm, Catherine; Davidson, John B.; Bacon, Barton J.; Murphy, Patrick C.; Ostroff, Aaron J.; Hoffler, Keith D.

1996-01-01

A flight research study of high-angle-of-attack handling qualities has been conducted at the NASA Dryden Flight Research Center using the F/A-18 High Alpha Research Vehicle (HARV). The objectives were to create a high-angle-of-attack handling qualities flight database, develop appropriate research evaluation maneuvers, and evaluate high-angle-of-attack handling qualities guidelines and criteria. Using linear and nonlinear simulations and flight research data, the predictions from each criterion were compared with the pilot ratings and comments. Proposed high-angle-of-attack nonlinear design guidelines and proposed handling qualities criteria and guidelines developed using piloted simulation were considered. Recently formulated time-domain Neal-Smith guidelines were also considered for application to high-angle-of-attack maneuvering. Conventional envelope criteria were evaluated for possible extension to the high-angle-of-attack regime. Additionally, the maneuvers were studied as potential evaluation techniques, including a limited validation of the proposed standard evaluation maneuver set. This paper gives an overview of these research objectives through examples and summarizes result highlights. The maneuver development is described briefly, the criteria evaluation is emphasized with example results given, and a brief discussion of the database form and content is presented.

Tradeoff methods in multiobjective insensitive design of airplane control systems

NASA Technical Reports Server (NTRS)

Schy, A. A.; Giesy, D. P.

1984-01-01

The latest results of an ongoing study of computer-aided design of airplane control systems are given. Constrained minimization algorithms are used, with the design objectives in the constraint vector. The concept of Pareto optimiality is briefly reviewed. It is shown how an experienced designer can use it to find designs which are well-balanced in all objectives. Then the problem of finding designs which are insensitive to uncertainty in system parameters are discussed, introducing a probabilistic vector definition of sensitivity which is consistent with the deterministic Pareto optimal problem. Insensitivity is important in any practical design, but it is particularly important in the design of feedback control systems, since it is considered to be the most important distinctive property of feedback control. Methods of tradeoff between deterministic and stochastic-insensitive (SI) design are described, and tradeoff design results are presented for the example of the a Shuttle lateral stability augmentation system. This example is used because careful studies have been made of the uncertainty in Shuttle aerodynamics. Finally, since accurate statistics of uncertain parameters are usually not available, the effects of crude statistical models on SI designs are examined.

Psychopathology and the Ability to Do Otherwise

PubMed Central

Pickard, Hanna

2015-01-01

When philosophers want an example of a person who lacks the ability to do otherwise, they turn to psychopathology. Addicts, agoraphobics, kleptomaniacs, neurotics, obsessives, and even psychopathic serial murderers, are all purportedly subject to irresistible desires that compel the person to act: no alternative possibility is supposed to exist. I argue that this conception of psychopathology is false and offer an empirically and clinically informed understanding of disorders of agency which preserves the ability to do otherwise. First, I appeal to standard clinical treatment for disorders of agency and argue that it undermines this conception of psychopathology. Second, I offer a detailed discussion of addiction, where our knowledge of the neurobiological mechanisms underpinning the disorder is relatively advanced. I argue that neurobiology notwithstanding, addiction is not a form of compulsion and I explain how addiction can impair behavioural control without extinguishing it. Third, I step back from addiction, and briefly sketch what the philosophical landscape more generally looks like without psychopathological compulsion: we lose our standard purported real-world example of psychologically determined action. I conclude by reflecting on the centrality of choice and free will to our concept of action, and their potency within clinical treatment for disorders of agency. PMID:25929318

[Therapy of orbital neoplasms in small animals].

PubMed

Spiess, B M; Rühli, M B; Bauer, G A

1995-10-01

The incidence, clinical signs and diagnostic work-up of orbital neoplasms is briefly discussed. The surgical management of such tumors is discussed in detail on the basis of three clinical cases. Long-term functional and cosmetic results are shown. Intraoperative and postoperative complications are discussed.

The need for an intermediate mass scale in GUTs

NASA Technical Reports Server (NTRS)

Shafi, Q.

1983-01-01

The minimal SU(5) grand unified field theory (GUT) model fails to resolve the strong charge parity (CP) problem, suffers from the cosmological monopole problem, sheds no light on the nature of the 'dark' mass in the universe, and predicts an unacceptably low value for the baryon asymmetry. All these problems can be overcome in suitable grand unified axion models with an intermediate mass scale of about 10 to the 11th power to 10 to the 12th power GeV. An example based on the gauge group SO(10) is presented. Among other things, it predicts that the axions comprise the 'dark' mass in the universe, and that there exists a galactic monopole flux of 10 to the -8th power to 10 to the -7th power/sq cm/yr. Other topics that are briefly discussed include proton decay, family symmetry, neutrino masses and the gauge hierarchy problem.

Asymptotic inference in system identification for the atom maser.

PubMed

Catana, Catalin; van Horssen, Merlijn; Guta, Madalin

2012-11-28

System identification is closely related to control theory and plays an increasing role in quantum engineering. In the quantum set-up, system identification is usually equated to process tomography, i.e. estimating a channel by probing it repeatedly with different input states. However, for quantum dynamical systems such as quantum Markov processes, it is more natural to consider the estimation based on continuous measurements of the output, with a given input that may be stationary. We address this problem using asymptotic statistics tools, for the specific example of estimating the Rabi frequency of an atom maser. We compute the Fisher information of different measurement processes as well as the quantum Fisher information of the atom maser, and establish the local asymptotic normality of these statistical models. The statistical notions can be expressed in terms of spectral properties of certain deformed Markov generators, and the connection to large deviations is briefly discussed.

Hybrid Integrated Label-Free Chemical and Biological Sensors

PubMed Central

Mehrabani, Simin; Maker, Ashley J.; Armani, Andrea M.

2014-01-01

Label-free sensors based on electrical, mechanical and optical transduction methods have potential applications in numerous areas of society, ranging from healthcare to environmental monitoring. Initial research in the field focused on the development and optimization of various sensor platforms fabricated from a single material system, such as fiber-based optical sensors and silicon nanowire-based electrical sensors. However, more recent research efforts have explored designing sensors fabricated from multiple materials. For example, synthetic materials and/or biomaterials can also be added to the sensor to improve its response toward analytes of interest. By leveraging the properties of the different material systems, these hybrid sensing devices can have significantly improved performance over their single-material counterparts (better sensitivity, specificity, signal to noise, and/or detection limits). This review will briefly discuss some of the methods for creating these multi-material sensor platforms and the advances enabled by this design approach. PMID:24675757

NASA spinoffs to bioengineering and medicine

NASA Technical Reports Server (NTRS)

Rouse, D. J.; Winfield, D. L.; Canada, S. C.

1991-01-01

Through the active transfer of technology, the National Aeronautics and Space Administration (NASA) Technology Utilization (TU) Program assists private companies, associations, and government agencies to make effective use of NASA's technological resources to improve U.S. economic competitiveness and to provide societal benefit. Aerospace technology from areas such as digital image processing, space medicine and biology, microelectronics, optics and electrooptics, and ultrasonic imaging have found many secondary applications in medicine. Examples of technology spinoffs are briefly discussed to illustrate the benefits realized through adaptation of aerospace technology to solve health care problems. Successful implementation of new technologies increasingly requires the collaboration of industry, universities, and government, and the TU Program serves as the liaison to establish such collaborations with NASA. NASA technology is an important resource to support the development of new medical products and techniques that will further advance the quality of health care available in the U.S. and worldwide.

Characterization and control of self-motions in redundant manipulators

NASA Technical Reports Server (NTRS)

Burdick, J.; Seraji, Homayoun

1989-01-01

The presence of redundant degrees of freedom in a manipulator structure leads to a physical phenomenon known as a self-motion, which is a continuous motion of the manipulator joints that leaves the end-effector motionless. In the first part of the paper, a global manifold mapping reformulation of manipulator kinematics is reviewed, and the inverse kinematic solution for redundant manipulators is developed in terms of self-motion manifolds. Global characterizations of the self-motion manifolds in terms of their number, geometry, homotopy class, and null space are reviewed using examples. Much previous work in redundant manipulator control has been concerned with the redundancy resolution problem, in which methods are developed to determine, or resolve, the motion of the joints in order to achieve end-effector trajectory control while optimizing additional objective functions. Redundancy resolution problems can be equivalently posed as the control of self-motions. Alternatives for redundancy resolution are briefly discussed.

Dynamics of intracellular processes in live-cell systems unveiled by fluorescence correlation microscopy.

PubMed

González Bardeci, Nicolás; Angiolini, Juan Francisco; De Rossi, María Cecilia; Bruno, Luciana; Levi, Valeria

2017-01-01

Fluorescence fluctuation-based methods are non-invasive microscopy tools especially suited for the study of dynamical aspects of biological processes. These methods examine spontaneous intensity fluctuations produced by fluorescent molecules moving through the small, femtoliter-sized observation volume defined in confocal and multiphoton microscopes. The quantitative analysis of the intensity trace provides information on the processes producing the fluctuations that include diffusion, binding interactions, chemical reactions and photophysical phenomena. In this review, we present the basic principles of the most widespread fluctuation-based methods, discuss their implementation in standard confocal microscopes and briefly revise some examples of their applications to address relevant questions in living cells. The ultimate goal of these methods in the Cell Biology field is to observe biomolecules as they move, interact with targets and perform their biological action in the natural context. © 2016 IUBMB Life, 69(1):8-15, 2017. © 2016 International Union of Biochemistry and Molecular Biology.

Biomedical applications of NASA technology

NASA Technical Reports Server (NTRS)

Friedman, Donald S.

1991-01-01

Through the active transfer of technology, NASA Technology Utilization (TU) Program assists private companies, associations, and government agencies to make effective use of NASA's technological resources to improve U.S. economic competitiveness and to provide societal benefit. Aerospace technology from such areas as digital image processing, space medicine and biology, microelectronics, optics, and electro-optics, and ultrasonic imaging have found many secondary applications in medicine. Examples of technology spinoffs are briefly discussed to illustrate the benefits realized through adaptation of aerospace technology to solve health care problems. Successful implementation of new technologies increasingly requires the collaboration of industry, universities, and government and the TU Program serves as the liaison to establish such collaborations with NASA. NASA technology is an important resource to support the development of new medical products and techniques that will further advance the quality of health care available in the U.S. and worldwide.

Complicated grief therapy as a new treatment approach

PubMed Central

Wetherell, Julie Loebach

2012-01-01

Complicated grief therapy (CGT) is a relatively new psychotherapy model designed to address symptoms of complicated grief. Drawn from attachment theory and with roots in both interpersonal therapy (IPT) and cognitive-behavioral therapy, CGT includes techniques similar to prolonged exposure (repeatedly telling the story of the death and in vivo exposure activities). The treatment also involves focusing on personal goals and relationships. CGT has been demonstrated to be effective in a trial in which participants with complicated grief were randomly assigned to CGT or IPT; individuals receiving CGT responded more quickly and were more likely to respond overall (51 % vs 28%). This article briefly summarizes the conceptual underpinnings of CGT, discusses the empirical evidence for its efficacy, describes its techniques, and presents a case example of a client treated in a 16-session manualized CGT protocol. The article concludes with a description of future research directions for CGT. PMID:22754288

Measurement of free radical kinetics in pulsed plasmas by UV and VUV absorption spectroscopy and by modulated beam mass spectrometry

NASA Astrophysics Data System (ADS)

Cunge, G.; Bodart, P.; Brihoum, M.; Boulard, F.; Chevolleau, T.; Sadeghi, N.

2012-04-01

This paper reviews recent progress in the development of time-resolved diagnostics to probe high-density pulsed plasma sources. We focus on time-resolved measurements of radicals' densities in the afterglow of pulsed discharges to provide useful information on production and loss mechanisms of free radicals. We show that broad-band absorption spectroscopy in the ultraviolet and vacuum ultraviolet spectral domain and threshold ionization modulated beam mass spectrometry are powerful techniques for the determination of the time variation of the radicals' densities in pulsed plasmas. The combination of these complementary techniques allows detection of most of the reactive species present in industrial etching plasmas, giving insights into the physico-chemistry reactions involving these species. As an example, we discuss briefly the radicals' kinetics in the afterglow of a SiCl4/Cl2/Ar discharge.

Computational Fluid Dynamics at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Kutler, Paul

1994-01-01

Computational fluid dynamics (CFD) is beginning to play a major role in the aircraft industry of the United States because of the realization that CFD can be a new and effective design tool and thus could provide a company with a competitive advantage. It is also playing a significant role in research institutions, both governmental and academic, as a tool for researching new fluid physics, as well as supplementing and complementing experimental testing. In this presentation, some of the progress made to date in CFD at NASA Ames will be reviewed. The presentation addresses the status of CFD in terms of methods, examples of CFD solutions, and computer technology. In addition, the role CFD will play in supporting the revolutionary goals set forth by the Aeronautical Policy Review Committee established by the Office of Science and Technology Policy is noted. The need for validated CFD tools is also briefly discussed.

Perturbative stability of SFT-based cosmological models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galli, Federico; Koshelev, Alexey S., E-mail: fgalli@tena4.vub.ac.be, E-mail: alexey.koshelev@vub.ac.be

2011-05-01

We review the appearance of multiple scalar fields in linearized SFT based cosmological models with a single non-local scalar field. Some of these local fields are canonical real scalar fields and some are complex fields with unusual coupling. These systems only admit numerical or approximate analysis. We introduce a modified potential for multiple scalar fields that makes the system exactly solvable in the cosmological context of Friedmann equations and at the same time preserves the asymptotic behavior expected from SFT. The main part of the paper consists of the analysis of inhomogeneous cosmological perturbations in this system. We show numericallymore » that perturbations corresponding to the new type of complex fields always vanish. As an example of application of this model we consider an explicit construction of the phantom divide crossing and prove the perturbative stability of this process at the linear order. The issue of ghosts and ways to resolve it are briefly discussed.« less

2D Organic Materials for Optoelectronic Applications.

PubMed

Yang, Fangxu; Cheng, Shanshan; Zhang, Xiaotao; Ren, Xiaochen; Li, Rongjin; Dong, Huanli; Hu, Wenping

2018-01-01

The remarkable merits of 2D materials with atomically thin structures and optoelectronic attributes have inspired great interest in integrating 2D materials into electronics and optoelectronics. Moreover, as an emerging field in the 2D-materials family, assembly of organic nanostructures into 2D forms offers the advantages of molecular diversity, intrinsic flexibility, ease of processing, light weight, and so on, providing an exciting prospect for optoelectronic applications. Herein, the applications of organic 2D materials for optoelectronic devices are a main focus. Material examples include 2D, organic, crystalline, small molecules, polymers, self-assembly monolayers, and covalent organic frameworks. The protocols for 2D-organic-crystal-fabrication and -patterning techniques are briefly discussed, then applications in optoelectronic devices are introduced in detail. Overall, an introduction to what is known and suggestions for the potential of many exciting developments are presented. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modeling of Casting Defects in an Integrated Computational Materials Engineering Approach

NASA Astrophysics Data System (ADS)

Sabau, Adrian S.

To accelerate the introduction of new cast alloys the modeling and simulation of multiphysical phenomena needs to be considered in the design and optimization of mechanical properties of cast components. The required models related to casting defects, such as microporosity and hot tears are reviewed. Three aluminum alloys are considered A356, 356 and 319. The data on calculated solidification shrinkage is presented and its effects on microporosity levels discussed. Examples are given for predicting microporosity defects and microstructure distribution for a plate casting. Models to predict fatigue life and yield stress are briefly highlighted here for the sake of completion and to illustrate how the length scales of the microstructure features as well as porosity defects are taken into account for modeling the mechanical properties. The data on casting defects including microstructure features, is crucial for evaluating the final performance-related properties of the component.

Description and Application of a Mathematical Method for the Analysis of Harmony

PubMed Central

Zuo, Qiting; Jin, Runfang; Ma, Junxia

2015-01-01

Harmony issues are widespread in human society and nature. To analyze these issues, harmony theory has been proposed as the main theoretical approach for the study of interpersonal relationships and relationships between humans and nature. Therefore, it is of great importance to study harmony theory. After briefly introducing the basic concepts of harmony theory, this paper expounds the five elements that are essential for the quantitative description of harmony issues in water resources management: harmony participant, harmony objective, harmony regulation, harmony factor, and harmony action. A basic mathematical equation for the harmony degree, that is, a quantitative expression of harmony issues, is introduced in the paper: HD = ai − bj, where a is the uniform degree, b is the difference degree, i is the harmony coefficient, and j is the disharmony coefficient. This paper also discusses harmony assessment and harmony regulation and introduces some application examples. PMID:26167535

Nano-liquid chromatography applied to enantiomers separation.

PubMed

Fanali, Salvatore

2017-02-24

This paper presents the state of the art concerning the separation of chiral compounds by means of nano-liquid chromatography (nano-LC). The enantiomers' separation and determination are a subject of fundamental importance in various application fields such as pharmaceutical industry, biomedicine, food, agrochemical etc. Nano-LC is a miniaturized chromatographic technique offering some advantages over conventional ones such as low consumption of mobile phase, sample volume and amount of chiral stationary phase, reduced costs etc. This is reported in the first part of the paper illustrating the features of the nano-LC. In addition, chiral resolution methods are briefly illustrated. Some chiral selectors, used in high-performance liquid chromatography have also been applied in nano-LC including cyclodextrins, glycopeptide antibiotics, modified polysaccharides etc. This is discussed in the second part of the review. Finally some examples of the applications available in literature are reported. Copyright © 2016 Elsevier B.V. All rights reserved.

Hair as an alternative matrix in bioanalysis.

PubMed

Barbosa, Joana; Faria, Juliana; Carvalho, Félix; Pedro, Madalena; Queirós, Odília; Moreira, Roxana; Dinis-Oliveira, Ricardo Jorge

2013-04-01

Alternative matrices are steadily gaining recognition as biological samples for toxicological analyses. Hair presents many advantages over traditional matrices, such as urine and blood, since it provides retrospective information regarding drug exposure, can distinguish between chronic and acute or recent drug use by segmental analysis, is easy to obtain, and has considerable stability for long periods of time. For this reason, it has been employed in a wide variety of contexts, namely to evaluate workplace drug exposure, drug-facilitated sexual assault, pre-natal drug exposure, anti-doping control, pharmacological monitoring and alcohol abuse. In this article, issues concerning hair structure, collection, storage and analysis are reviewed. The mechanisms of drug incorporation into hair are briefly discussed. Analytical techniques for simultaneous drug quantification in hair are addressed. Finally, representative examples of drug quantification using hair are summarized, emphasizing its potentialities and limitations as an alternative biological matrix for toxicological analyses.

Additive manufacturing of optical components

NASA Astrophysics Data System (ADS)

Heinrich, Andreas; Rank, Manuel; Maillard, Philippe; Suckow, Anne; Bauckhage, Yannick; Rößler, Patrick; Lang, Johannes; Shariff, Fatin; Pekrul, Sven

2016-08-01

The development of additive manufacturing methods has enlarged rapidly in recent years. Thereby, the work mainly focuses on the realization of mechanical components, but the additive manufacturing technology offers a high potential in the field of optics as well. Owing to new design possibilities, completely new solutions are possible. This article briefly reviews and compares the most important additive manufacturing methods for polymer optics. Additionally, it points out the characteristics of additive manufactured polymer optics. Thereby, surface quality is of crucial importance. In order to improve it, appropriate post-processing steps are necessary (e.g. robot polishing or coating), which will be discussed. An essential part of this paper deals with various additive manufactured optical components and their use, especially in optical systems for shape metrology (e.g. borehole sensor, tilt sensor, freeform surface sensor, fisheye lens). The examples should demonstrate the potentials and limitations of optical components produced by additive manufacturing.

Small mitochondria-targeting molecules as anti-cancer agents

PubMed Central

Wang, Feng; Ogasawara, Marcia A.; Huang, Peng

2009-01-01

Alterations in mitochondrial structure and functions have long been observed in cancer cells. Targeting mitochondria as a cancer therapeutic strategy has gained momentum in the recent years. The signaling pathways that govern mitochondrial function, apoptosis and molecules that affect mitochondrial integrity and cell viability have been important topics of the recent review in the literature. In this article, we first briefly summarize the rationale and biological basis for developing mitochondrial-targeted compounds as potential anticancer agents, and then provide key examples of small molecules that either directly impact mitochondria or functionally affect the metabolic alterations in cancer cells with mitochondrial dysfunction. The main focus is on the small molecular weight compounds with potential applications in cancer treatment. We also summarize information on the drug developmental stages of the key mitochondria-targeted compounds and their clinical trial status. The advantages and potential shortcomings of targeting the mitochondria for cancer treatment are also discussed. PMID:19995573

Emerging roles of lysine methylation on non-histone proteins.

PubMed

Zhang, Xi; Huang, Yaling; Shi, Xiaobing

2015-11-01

Lysine methylation is a common posttranslational modification (PTM) of histones that is important for the epigenetic regulation of transcription and chromatin in eukaryotes. Increasing evidence demonstrates that in addition to histones, lysine methylation also occurs on various non-histone proteins, especially transcription- and chromatin-regulating proteins. In this review, we will briefly describe the histone lysine methyltransferases (KMTs) that have a broad spectrum of non-histone substrates. We will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysine methylation and other PTMs in regulating the functions of the modified proteins. Understanding the roles of lysine methylation in normal cells and during development will shed light on the complex biology of diseases associated with the dysregulation of lysine methylation on both histones and non-histone proteins.

A review on current status of antiviral siRNA.

PubMed

Qureshi, Abid; Tantray, Vaqar Gani; Kirmani, Altaf Rehman; Ahangar, Abdul Ghani

2018-04-15

Viral diseases like influenza, AIDS, hepatitis, and Ebola cause severe epidemics worldwide. Along with their resistant strains, new pathogenic viruses continue to be discovered so creating an ongoing need for new antiviral treatments. RNA interference is a cellular gene-silencing phenomenon in which sequence-specific degradation of target mRNA is achieved by means of complementary short interfering RNA (siRNA) molecules. Short interfering RNA technology affords a potential tractable strategy to combat viral pathogenesis because siRNAs are specific, easy to design, and can be directed against multiple strains of a virus by targeting their conserved gene regions. In this review, we briefly summarize the current status of siRNA therapy for representative examples from different virus families. In addition, other aspects like their design, delivery, medical significance, bioinformatics resources, and limitations are also discussed. Copyright © 2018 John Wiley & Sons, Ltd.

Verification of low-Mach number combustion codes using the method of manufactured solutions

NASA Astrophysics Data System (ADS)

Shunn, Lee; Ham, Frank; Knupp, Patrick; Moin, Parviz

2007-11-01

Many computational combustion models rely on tabulated constitutive relations to close the system of equations. As these reactive state-equations are typically multi-dimensional and highly non-linear, their implications on the convergence and accuracy of simulation codes are not well understood. In this presentation, the effects of tabulated state-relationships on the computational performance of low-Mach number combustion codes are explored using the method of manufactured solutions (MMS). Several MMS examples are developed and applied, progressing from simple one-dimensional configurations to problems involving higher dimensionality and solution-complexity. The manufactured solutions are implemented in two multi-physics hydrodynamics codes: CDP developed at Stanford University and FUEGO developed at Sandia National Laboratories. In addition to verifying the order-of-accuracy of the codes, the MMS problems help highlight certain robustness issues in existing variable-density flow-solvers. Strategies to overcome these issues are briefly discussed.

Radiation forces on small particles in the solar system

NASA Technical Reports Server (NTRS)

Burns, J. A.; Lamy, P. L.; Soter, S.

1979-01-01

Solar radiation forces on small particles in the solar system are examined, and the resulting orbital evolution of interplanetary and circumplanetary dust is considered. An expression is derived for the effects of radiation pressure and Poynting-Robertson drag on small, spherical particles using the energy and momentum transformation laws of special relativity, and numerical examples are presented to illustrate that radiation pressure and Poynting-Robertson drag are only important for particles within a narrow size range. The orbital consequences of these radiation forces are considered both for heliocentric and planetocentric orbiting particles, and the coupling between particle sizes and dynamics is discussed. A qualitative derivation is presented for the differential Doppler effect, which is due to the differential Doppler shifting of radiation from approaching and receding solar hemispheres, and the Yarkovsky effect, which is important for rotating meter-to kilometer-sized particles, is briefly described.

Changing news: re-adjusting science studies to online newspapers.

PubMed

Riesch, Hauke

2011-11-01

With the newspapers' recent move to online reporting, traditional norms and practices of news reporting have changed to accommodate the new realities of online news writing. In particular, online news is much more fluid and prone to change in content than the traditional hard-copy newspapers--online newspaper articles often change over the course of the following days or even weeks as they respond to criticisms and new information becoming available. This poses a problem for social scientists who analyse newspaper coverage of science, health and risk topics, because it is no longer clear who has read and written what version, and what impact they potentially had on the national debates on these topics. In this note I want to briefly flag up this problem through two recent examples of U.K. national science stories and discuss the potential implications for PUS media research.

Redox cofactor engineering in industrial microorganisms: strategies, recent applications and future directions.

PubMed

Liu, Jiaheng; Li, Huiling; Zhao, Guangrong; Caiyin, Qinggele; Qiao, Jianjun

2018-05-01

NAD and NADP, a pivotal class of cofactors, which function as essential electron donors or acceptors in all biological organisms, drive considerable catabolic and anabolic reactions. Furthermore, they play critical roles in maintaining intracellular redox homeostasis. However, many metabolic engineering efforts in industrial microorganisms towards modification or introduction of metabolic pathways, especially those involving consumption, generation or transformation of NAD/NADP, often induce fluctuations in redox state, which dramatically impede cellular metabolism, resulting in decreased growth performance and biosynthetic capacity. Here, we comprehensively review the cofactor engineering strategies for solving the problematic redox imbalance in metabolism modification, as well as their features, suitabilities and recent applications. Some representative examples of in vitro biocatalysis are also described. In addition, we briefly discuss how tools and methods from the field of synthetic biology can be applied for cofactor engineering. Finally, future directions and challenges for development of cofactor redox engineering are presented.

Ethnographies of pain: culture, context and complexity

PubMed Central

2015-01-01

This article briefly introduces and discusses the value of ethnographic research, particularly research hailing from the discipline of social and cultural anthropology. After an introduction to ethnography in general, key ethnographic studies of pain are described. These show that ethnography provides a set of techniques for data collection and analysis, as well as a way of thinking about pain as socially and culturally embedded. Modern ethnographic writing is far removed from the literature of the past that sometimes described stereotypes rather than process and complexity. Ethnography provides the chance to describe the complexity and nuance of culture, which serves to counter stereotypes. The article concludes with an example from pain research conducted in a clinical setting. Through the use of ethnographic techniques, the research study provided greater insight than other methods alone might have achieved. The article includes references for further reading should readers be interested in developing their engagement with ethnographic method and interpretation. PMID:26516554

Calibration and operation of the Faint Object Spectrograph

NASA Technical Reports Server (NTRS)

Harms, R.; Beaver, E.; Burbidge, E.; Hier, R.; Allen, R.; Angel, R.; Bartko, F.; Bohlin, R.; Ford, H.; Davidson, A.

1984-01-01

The design and basic performance characteristics of the Faint Object Spectrograph (FOS), one of five instruments built for use on the Space Telescope observatory, is summarized briefly. The results of the recently completed instrument-level calibration are presented with special emphasis on issues affecting plans for FOS astronomical observations. Examples include such fundamental characteristics as: limiting magnitudes (system sensitivity and noise figures), spectral coverage and resolution, scattered light properties, and instrumental polarization and modulation efficiencies. Also gated toward intended users, a rather detailed description of FOS operating modes is given. The discussion begins with the difficulties anticipated during target acquisition and their hoped-for resolution. Both the 'normal' spectroscopic operating modes of the FOS and its 'exotic' features (e.g. spectropolarimetric, time-tagged, and time-resolved modes) are presented. The paper concludes with an overview of the activities to assure proper alignment and operation of the FOS within the entire Space Telescope system (orbital and ground-based).

Complicated grief therapy as a new treatment approach.

PubMed

Wetherell, Julie Loebach

2012-06-01

Complicated grief therapy (CGT) is a relatively new psychotherapy model designed to address symptoms of complicated grief. Drawn from attachment theory and with roots in both interpersonal therapy (IPT) and cognitive-behavioral therapy, CGT includes techniques similar to prolonged exposure (repeatedly telling the story of the death and in vivo exposure activities). The treatment also involves focusing on personal goals and relationships. CGT has been demonstrated to be effective in a trial in which participants with complicated grief were randomly assigned to CGT or IPT; individuals receiving CGT responded more quickly and were more likely to respond overall (51% vs 28%). This article briefly summarizes the conceptual underpinnings of CGT, discusses the empirical evidence for its efficacy, describes its techniques, and presents a case example of a client treated in a 16-session manualized CGT protocol. The article concludes with a description of future research directions for CGT.

Could the extensive use of rare elements in renewable energy technologies become a cause for concern?

NASA Astrophysics Data System (ADS)

Bradshaw, A. M.; Reuter, B.; Hamacher, T.

2015-08-01

The energy transformation process beginning to take place in many countries as a response to climate change will reduce substantially the consumption of fossil fuels, but at the same time cause a large increase in the demand for other raw materials. Whereas it is difficult to estimate the quantities of, for example, iron, copper and aluminium required, the situation is somewhat simpler for the rare elements that might be needed in a sustainable energy economy based largely on photovoltaic sources, wind and possibly nuclear fusion. We consider briefly each of these technologies and discuss the supply risks associated with the rare elements required, if they were to be used in the quantities that might be required for a global energy transformation process. In passing, we point out the need in resource studies to define the terms "rare", "scarce" and "critical" and to use them in a consistent way.

Social network analysis for program implementation.

PubMed

Valente, Thomas W; Palinkas, Lawrence A; Czaja, Sara; Chu, Kar-Hai; Brown, C Hendricks

2015-01-01

This paper introduces the use of social network analysis theory and tools for implementation research. The social network perspective is useful for understanding, monitoring, influencing, or evaluating the implementation process when programs, policies, practices, or principles are designed and scaled up or adapted to different settings. We briefly describe common barriers to implementation success and relate them to the social networks of implementation stakeholders. We introduce a few simple measures commonly used in social network analysis and discuss how these measures can be used in program implementation. Using the four stage model of program implementation (exploration, adoption, implementation, and sustainment) proposed by Aarons and colleagues [1] and our experience in developing multi-sector partnerships involving community leaders, organizations, practitioners, and researchers, we show how network measures can be used at each stage to monitor, intervene, and improve the implementation process. Examples are provided to illustrate these concepts. We conclude with expected benefits and challenges associated with this approach.

Hydrophobic and Hydrophilic Au and Ag Nanoparticles. Breakthroughs and Perspectives

PubMed Central

2017-01-01

This review provides a broad look on the recent investigations on the synthesis, characterization and physico-chemical properties of noble metal nanoparticles, mainly gold and silver nanoparticles, stabilized with ligands of different chemical nature. A comprehensive review of the available literature in this field may be far too large and only some selected representative examples will be reported here, together with some recent achievements from our group, that will be discussed in more detail. Many efforts in finding synthetic routes have been performed so far to achieve metal nanoparticles with well-defined size, morphology and stability in different environments, to match the large variety of applications that can be foreseen for these materials. In particular, the synthesis and stabilization of gold and silver nanoparticles together with their properties in different emerging fields of nanomedicine, optics and sensors are reviewed and briefly commented. PMID:29280980

Development of a quality assurance program for ionizing radiation secondary calibration laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heaton, H.T. II; Taylor, A.R. Jr.

For calibration laboratories, routine calibrations of instruments meeting stated accuracy goals are important. One method of achieving the accuracy goals is to establish and follow a quality assurance program designed to monitor all aspects of the calibration program and to provide the appropriate feedback mechanism if adjustments are needed. In the United States there are a number of organizations with laboratory accreditation programs. All existing accreditation programs require that the laboratory implement a quality assurance program with essentially the same elements in all of these programs. Collectively, these elements have been designated as a Measurement Quality Assurance (MQA) program. Thismore » paper will briefly discuss the interrelationship of the elements of an MQA program. Using the Center for Devices and Radiological Health (CDRH) X-ray Calibration Laboratory (XCL) as an example, it will focus on setting up a quality control program for the equipment in a Secondary Calibration Laboratory.« less

An uncertainty analysis of the flood-stage upstream from a bridge.

PubMed

Sowiński, M

2006-01-01

The paper begins with the formulation of the problem in the form of a general performance function. Next the Latin hypercube sampling (LHS) technique--a modified version of the Monte Carlo method is briefly described. The essential uncertainty analysis of the flood-stage upstream from a bridge starts with a description of the hydraulic model. This model concept is based on the HEC-RAS model developed for subcritical flow under a bridge without piers in which the energy equation is applied. The next section contains the characteristic of the basic variables including a specification of their statistics (means and variances). Next the problem of correlated variables is discussed and assumptions concerning correlation among basic variables are formulated. The analysis of results is based on LHS ranking lists obtained from the computer package UNCSAM. Results fot two examples are given: one for independent and the other for correlated variables.

Developmental history and application of CRISPR in human disease.

PubMed

Liang, Puping; Zhang, Xiya; Chen, Yuxi; Huang, Junjiu

2017-06-01

Genome-editing tools are programmable artificial nucleases, mainly including zinc-finger nucleases, transcription activator-like effector nucleases and clustered regularly interspaced short palindromic repeat (CRISPR). By recognizing and cleaving specific DNA sequences, genome-editing tools make it possible to generate site-specific DNA double-strand breaks (DSBs) in the genome. DSBs will then be repaired by either error-prone nonhomologous end joining or high-fidelity homologous recombination mechanisms. Through these two different mechanisms, endogenous genes can be knocked out or precisely repaired/modified. Rapid developments in genome-editing tools, especially CRISPR, have revolutionized human disease models generation, for example, various zebrafish, mouse, rat, pig, monkey and human cell lines have been constructed. Here, we review the developmental history of CRISPR and its application in studies of human diseases. In addition, we also briefly discussed the therapeutic application of CRISPR in the near future. Copyright © 2017 John Wiley & Sons, Ltd.

Social Network Analysis for Program Implementation

PubMed Central

Valente, Thomas W.; Palinkas, Lawrence A.; Czaja, Sara; Chu, Kar-Hai; Brown, C. Hendricks

2015-01-01

This paper introduces the use of social network analysis theory and tools for implementation research. The social network perspective is useful for understanding, monitoring, influencing, or evaluating the implementation process when programs, policies, practices, or principles are designed and scaled up or adapted to different settings. We briefly describe common barriers to implementation success and relate them to the social networks of implementation stakeholders. We introduce a few simple measures commonly used in social network analysis and discuss how these measures can be used in program implementation. Using the four stage model of program implementation (exploration, adoption, implementation, and sustainment) proposed by Aarons and colleagues [1] and our experience in developing multi-sector partnerships involving community leaders, organizations, practitioners, and researchers, we show how network measures can be used at each stage to monitor, intervene, and improve the implementation process. Examples are provided to illustrate these concepts. We conclude with expected benefits and challenges associated with this approach. PMID:26110842

RNA Characterization by Solid-State NMR Spectroscopy.

PubMed

Yang, Yufei; Wang, Shenlin

2018-06-21

The structures of RNAs, which play critical roles in various biological processes, provide important clues and insights into the biological functions of these molecules. However, RNA structure determination remains a challenging topic. In recent years, magic-angle-spinning solid-state NMR (MAS SSNMR) has emerged as an alternative technique for structural and dynamic characterization of RNA. MAS SSNMR has been successfully applied to provide atomic-level structural information about several RNA molecules and RNA-protein complexes. In this Minireview, we give an overview of recent progress in the field of MAS SSNMR based RNA structural characterization, and introduce sample preparation strategies and SSNMR spectroscopic techniques that have been incorporated to identify RNA structural elements. We also highlight a few impressive examples of RNAs that have been investigated extensively by SSNMR. Finally, we briefly discuss future technical trends in the use of MAS SSNMR to facilitate RNA structure determination. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pressure Contact Sounding Data for NASA's Atmospheric Variability Experiment (AVE 3)

NASA Technical Reports Server (NTRS)

Fuelberg, H. E.; Hill, C. K.; Turner, R. E.; Long, K. E.

1975-01-01

The basic rawinsonde data are described at each pressure contact from the surface to sounding termination for the 41 stations participating in the AVE III measurement program that began at 0000 GMT on February 6 and ended at 1200 GMT on February 7, 1975. Soundings were taken at 3-hour intervals during a large period of the experiment from most stations within the United States east of about 105 degrees west longitude. Methods of data processing, change in reduction scheme since the AVE II pilot experiment, and data accuracy are briefly discussed. An example of contact data is presented, and microfiche cards of all the contact data are included in the appendix. The AVE III project was conducted to better understand and establish the extent of applications for meteorological satellite sensor data through correlative ground truth experiments and to provide basic experimental data for use in studies of atmospheric scales of-motion interrelationships.

Hybrid integrated label-free chemical and biological sensors.

PubMed

Mehrabani, Simin; Maker, Ashley J; Armani, Andrea M

2014-03-26

Label-free sensors based on electrical, mechanical and optical transduction methods have potential applications in numerous areas of society, ranging from healthcare to environmental monitoring. Initial research in the field focused on the development and optimization of various sensor platforms fabricated from a single material system, such as fiber-based optical sensors and silicon nanowire-based electrical sensors. However, more recent research efforts have explored designing sensors fabricated from multiple materials. For example, synthetic materials and/or biomaterials can also be added to the sensor to improve its response toward analytes of interest. By leveraging the properties of the different material systems, these hybrid sensing devices can have significantly improved performance over their single-material counterparts (better sensitivity, specificity, signal to noise, and/or detection limits). This review will briefly discuss some of the methods for creating these multi-material sensor platforms and the advances enabled by this design approach.

Space-Based Space Surveillance Logistics Case Study: A Qualitative Product Support Element Analysis

DTIC Science & Technology

2017-12-01

Facilities and Infrastructure. Product Support Management and Design Interface are also covered, but only in a general manner. Conclusions from the study...core analysis, with the overarching two elements ( Design Interface and Product Support Management) mentioned briefly. G. THESIS STATEMENT This...were implemented. The two overarching elements of Product Support Management and Design Interface will be discussed briefly in the findings section

Cathodoluminescence Petrography: A Valuable Tool for Teaching and Research.

ERIC Educational Resources Information Center

Kopp, Otto C.

1981-01-01

Cathodoluminescence is visible light emitted from a specimen when it is bombarded with electrons. A technique known as cathodoluminescence petrography can provide information especially useful in studies or courses related to mineralogy and petrology. The technique is briefly presented, along with examples to illustrate typical results. (Author/WB)

Recent meteor observing activities in Japan

NASA Astrophysics Data System (ADS)

Yamamoto, M.

2005-02-01

The meteor train observation (METRO) campaign is described as an example of recent meteor observing activity in Japan. Other topics of meteor observing activities in Japan, including Ham-band radio meteor observation, the ``Japan Fireball Network'', the automatic video-capture software ``UFOCapture'', and the Astro-classroom programme are also briefly introduced.

Why Excel?

ERIC Educational Resources Information Center

Barreto, Humberto

2015-01-01

This article is not the usual Excel pedagogy fare in that it does not provide an application or example taught via a spreadsheet. Instead, it briefly reviews the history of spreadsheets in the economics classroom and explores the current environment, with an emphasis on modern learning theory. The conclusion is not surprising: spreadsheets improve…

Using Rational-Emotive Therapy to Prevent Classroom Problems.

ERIC Educational Resources Information Center

Webber, Jo; Coleman, Maggie

1988-01-01

Teachers are encouraged to utilize rational-emotive therapy to prevent and deal with classroom behavior problems. Rational-emotive therapy is defined, the ABC model of rational thinking briefly explained, types of irrational thinking identified, and suggestions for becoming a rational thinker are offered. Classroom examples are given. (DB)

Migration and sorption phenomena in packaged foods.

PubMed

Gnanasekharan, V; Floros, J D

1997-10-01

Rapidly developing analytical capabilities and continuously evolving stringent regulations have made food/package interactions a subject of intense research. This article focuses on: (1) the migration of package components such as oligomers and monomers, processing aids, additives, and residual reactants in to packaged foods, and (2) sorption of food components such as flavors, lipids, and moisture into packages. Principles of diffusion and thermodynamics are utilized to describe the mathematics of migration and sorption. Mathematical models are developed from first principles, and their applicability is illustrated using numerical simulations and published data. Simulations indicate that available models are system (polymer-penetrant) specific. Furthermore, some models best describe the early stages of migration/sorption, whereas others should be used for the late stages of these phenomena. Migration- and/or sorption-related problems with respect to glass, metal, paper-based and polymeric packaging materials are discussed, and their importance is illustrated using published examples. The effects of migrating and absorbed components on food safety, quality, and the environment are presented for various foods and packaging materials. The impact of currently popular packaging techniques such as microwavable, ovenable, and retortable packaging on migration and sorption are discussed with examples. Analytical techniques for investigating migration and sorption phenomena in food packaging are critically reviewed, with special emphasis on the use and characteristics of food-simulating liquids (FSLs). Finally, domestic and international regulations concerning migration in packaged foods, and their impact on food packaging is briefly presented.

Botallo's error, or the quandaries of the universality assumption.

PubMed

Bartolomeo, Paolo; Seidel Malkinson, Tal; de Vito, Stefania

2017-01-01

One of the founding principles of human cognitive neuroscience is the so-called universality assumption, the postulate that neurocognitive mechanisms do not show major differences among individuals. Without negating the importance of the universality assumption for the development of cognitive neuroscience, or the importance of single-case studies, here we aim at stressing the potential dangers of interpreting the pattern of performance of single patients as conclusive evidence concerning the architecture of the intact neurocognitive system. We take example from the case of Leonardo Botallo, an Italian surgeon of the Renaissance period, who claimed to have discovered a new anatomical structure of the adult human heart. Unfortunately, Botallo's discovery was erroneous, because what he saw in the few samples he examined was in fact the anomalous persistence of a fetal structure. Botallo's error is a reminder of the necessity to always strive for replication, despite the major hindrance of a publication system heavily biased towards novelty. In the present paper, we briefly discuss variations and anomalies in human brain anatomy and introduce the issue of variability in cognitive neuroscience. We then review some examples of the impact on cognition of individual variations in (1) brain structure, (2) brain functional organization and (3) brain damage. We finally discuss the importance and limits of single case studies in the neuroimaging era, outline potential ways to deal with individual variability, and draw some general conclusions. Copyright © 2016 Elsevier Ltd. All rights reserved.

MONTHLY REPORT OF DEVELOPMENT, SEPTEMBER 1963

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1964-10-31

Methods for separating germanium from Taiga carbonaceous shale by flotation and salt roasting are described. The recovery of vanadium from Beaverlodge mill tailings by carbonate leaching is briefly discussed. Methods of chemical analysis are also discussed. (N.W.R.)

Scrutiny of the Bounty or Teaching Critical Thinking in

ERIC Educational Resources Information Center

Cash, D. Michele

This paper, presented at the Indiana Library Association Meeting, discusses critical thinking in general terms and then briefly discusses why it is important to include critical thinking skills in bibliographic instruction sessions at the higher education level. A discussion of the instructional design of bibliographic instruction in relation to…

Current and future contraceptive options for women living with HIV

PubMed Central

Patel, Rena C.; Bukusi, Elizabeth A.; Baeten, Jared M.

2018-01-01

Introduction Among women living with HIV, half of the pregnancies are unintended. Effective contraception can prevent unintended pregnancies and consequently reduce maternal mortality and perinatal transmission of HIV. While contraceptive options available for all women also apply to women living with HIV, specific considerations exist to the use of contraception by women living with HIV. Areas covered First, general principles guiding the use of contraception among women living with HIV are discussed, such as choice, method mix, relative effectiveness, and drug-drug interactions. Second, a detailed discussion of each contraceptive method and issues surrounding the use of that method, such as drug-drug interactions, follows. Third, future contraceptive options in advanced development for use by women or men are briefly discussed. Expert opinion Contraceptive methods available to all women should also be accessible to women living with HIV. When the relative effectiveness of a contraceptive method is reduced, for example due to drug-drug interactions with antiretrovirals, the method should still be made available to women living with HIV with the appropriate information sharing and counseling. Greater research on various aspects of contraceptive use by women living with HIV and more comprehensive testing of co-administration of hormonal contraceptives and common medications used by these women are warranted. PMID:28891343

Current and future contraceptive options for women living with HIV.

PubMed

Patel, Rena C; Bukusi, Elizabeth A; Baeten, Jared M

2018-01-01

Among women living with HIV, half of the pregnancies are unintended. Effective contraception can prevent unintended pregnancies and consequently reduce maternal mortality and perinatal transmission of HIV. While contraceptive options available for all women also apply to women living with HIV, specific considerations exist to the use of contraception by women living with HIV. Areas covered: First, general principles guiding the use of contraception among women living with HIV are discussed, such as choice, method mix, relative effectiveness, and drug-drug interactions. Second, a detailed discussion of each contraceptive method and issues surrounding the use of that method, such as drug-drug interactions, follows. Third, future contraceptive options in advanced development for use by women or men are briefly discussed. Expert opinion: Contraceptive methods available to all women should also be accessible to women living with HIV. When the relative effectiveness of a contraceptive method is reduced, for example due to drug-drug interactions with antiretrovirals, the method should still be made available to women living with HIV with the appropriate information sharing and counseling. Greater research on various aspects of contraceptive use by women living with HIV and more comprehensive testing of co-administration of hormonal contraceptives and common medications used by these women are warranted.

Analysis of Ti and TiO2 nanolayers by total reflection X-ray photoelectron spectroscopy

NASA Astrophysics Data System (ADS)

Kubala-Kukuś, A.; Banaś, D.; Stabrawa, I.; Szary, K.; Sobota, D.; Majewska, U.; Wudarczyk-Moćko, J.; Braziewicz, J.; Pajek, M.

2018-07-01

Total reflection X-ray photoelectron spectroscopy (TRXPS) is applied in the analysis of Ti and TiO2 nanolayers deposited on silicon and silicon dioxide substrates. The idea of application of total-reflection phenomenon for exciting X-ray used in the XPS technique is briefly discussed. The experimental setup and measurement conditions for the studied Ti and TiO2 layers are presented. The XPS spectra were registered both for the non-total and total reflection regimes. The survey spectra and C1s, N1s, Ti2p and O1s photoelectron peaks are shown. For energy calibration, the position of C1s photoelectron peak was applied (C-C component, binding energy 284.8 eV). The peak to background ratios are discussed as regards the dependence of the excitation angle. An increase of this ratio for the glancing angle 1°, being below critical angle of the X-ray beam and sample material, results in an improvement of XPS detection limit by factor up to 2. In the case of the Ti nanolayer, additionally, the thickness of the overlayer TiO2 is determined. As an example of applying the TRXPS technique, the analysis of Ti nanolayers implanted by highly charged Xe35+ ions of 280 keV energy is discussed. The Xe3d and O1s photoelectron peaks are presented and discussed.

Overview of the 5 Rs

EPA Science Inventory

This introduction to the lunchtime symposium and panel discussion introduces the panel topics and participants from across the spectrum of organizations who have responded to large scale disasters. This overview will briefly discuss the role of exposure science during each phase ...

Remote sensing as a tool in assessing soil moisture

NASA Technical Reports Server (NTRS)

Carlson, C. W.

1978-01-01

The effects of soil moisture as it relates to agriculture is briefly discussed. The use of remote sensing to predict scheduling of irrigation, runoff and soil erosion which contributes to the prediction of crop yield is also discussed.

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2013 CFR

2013-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2012 CFR

2012-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2014 CFR

2014-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2011 CFR

2011-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2010 CFR

2010-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

What Is the Role of Group Parent Training in the Treatment of ADD Children?

ERIC Educational Resources Information Center

Barkley, Russell A.

1986-01-01

The nature of behavioral deficiencies in children with Attention Deficit Disorders are briefly described. The use of group parent training is recommended as the most cost-effective method for helping parents. Steps involved in implementing such a program and a case example are provided. (Author/DB)

The Technology Implications of "A Nation at Risk"

ERIC Educational Resources Information Center

Allen, Lee

2008-01-01

In 1983, when "A Nation at Risk" appeared, it offered recommendations in the areas of content, standards and expectations, time, teaching, and leadership and fiscal support. The growing use of technology was addressed briefly in the section dealing with "indicators of risk," which listed examples of deficiencies in education as compared to the…

Navigation. Northern New England Marine Education Project.

ERIC Educational Resources Information Center

Maine Univ., Orono. Coll. of Education.

This guide provides student practice problems which use the procedures of ship navigators to reinforce the skills of mathematics learned in the secondary school and which seek to provide examples of the application of mathematical concepts. Along with the practice problems, teacher background material is provided briefly in the body of the unit.…

Hope, Illness, and Counselling Practice: Making Hope Visible.

ERIC Educational Resources Information Center

Edey, Wendy; Jevne, Ronna F.

2003-01-01

Draws on some of the literature from the fields of nursing and psychology which links counseling practice, hope, and illness. Addresses the issue of false hope and the challenge of being a hopeful counselor. Two working examples are used to suggest and briefly demonstrate interventions counselors might make. (Contains 31 references.) (GCP)

The role of automation and robotics in space stations

NASA Technical Reports Server (NTRS)

Black, D. C.

1985-01-01

Automation and robotics have played important roles in space research, most notably in planetary exploration. While an increased need for automation and robotics in space research is anticipated, some of the major challenges and opportunities for automation and robotics will be provided by the Space Station. Examples of these challenges are briefly reviewed.

The College Does It Better. A Resource for Colleges of Further Education.

ERIC Educational Resources Information Center

Further Education Unit, London (England).

This resource contains checklists, worksheets, and examples to encourage staff to share their views and to precipitate action. It assumes an open system of college management with a desire to be efficiently and effectively responsive to local needs. Section I describes briefly some challenges the further education system faces. Section II…

ELSA and RRI--Editorial.

PubMed

Forsberg, Ellen-Marie

2015-01-01

This editorial presents the background for the article collection 'ELSA and RRI'. It sets the stage for the topics discussed in the collection and briefly presents the different contributions. It concludes by opening up for continued discussion of the relations between ELSA and RRI.

ENVIRONMENTAL TECHNOLOGY VERIFICATION: CREDIBLE PERFORMANCE DATA FOR TECHNOLOGY USERS

EPA Science Inventory

The paper summarizes accomplishments of EPA's Environmental Technology Verification (ETV) Program, discusses lessons learned during the pilot period, briefly notes the restructuring of the pilot programs into six centers beginning in late 2000, and discusses in detail the Air Pol...

Responding to the changing regulatory scene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wise, P.

1995-12-31

The regulatory approach of the Illinois Environmental Protection Agency (EPA) is discussed in this paper. Three areas receive emphasis: (1) the changing relations between the US EPA and the states, (2) the new emphasis on pollution prevention techniques, and (3) a new environmental amnesty project. Budgetary considerations, performance partnerships, and nonregulatory compliance assistance are briefly outlined in relation to these topics. Results of the environmental amnesty program for small business, called Clean Break, are briefly reported.

Effects of thermal cycling on composite materials for space structures

NASA Technical Reports Server (NTRS)

Tompkins, Stephen S.

1989-01-01

The effects of thermal cycling on the thermal and mechanical properties of composite materials that are candidates for space structures are briefly described. The results from a thermal analysis of the orbiting Space Station Freedom is used to define a typical thermal environment and the parameters that cause changes in the thermal history. The interactions of this environment with composite materials are shown and described. The effects of this interaction on the integrity as well as the properties of GR/thermoset, Gr/thermoplastic, Gr/metal and Gr/glass composite materials are discussed. Emphasis is placed on the effects of the interaction that are critical to precision spacecraft. Finally, ground test methodology are briefly discussed.

Long-range, low-cost electric vehicles enabled by robust energy storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Ping; Ross, Russel; Newman, Aron

2015-09-18

ABSTRACT A variety of inherently robust energy storage technologies hold the promise to increase the range and decrease the cost of electric vehicles (EVs). These technologies help diversify approaches to EV energy storage, complementing current focus on high specific energy lithium-ion batteries. The need for emission-free transportation and a decrease in reliance on imported oil has prompted the development of EVs. To reach mass adoption, a significant reduction in cost and an increase in range are needed. Using the cost per mile of range as the metric, we analyzed the various factors that contribute to the cost and weight ofmore » EV energy storage systems. Our analysis points to two primary approaches for minimizing cost. The first approach, of developing redox couples that offer higher specific energy than state-of-the-art lithium-ion batteries, dominates current research effort, and its challenges and potentials are briefly discussed. The second approach represents a new insight into the EV research landscape. Chemistries and architectures that are inherently more robust reduce the need for system protection and enables opportunities of using energy storage systems to simultaneously serve vehicle structural functions. This approach thus enables the use of low cost, lower specific energy chemistries without increasing vehicle weight. Examples of such systems include aqueous batteries, flow cells, and all solid-state batteries. Research progress in these technical areas is briefly reviewed. Potential research directions that can enable low-cost EVs using multifunctional energy storage technologies are described.« less

Erickson and Rogers: The Differences Do Make a Difference.

ERIC Educational Resources Information Center

Lopez, Frederick G.

1987-01-01

Extends an earlier discussion by Gunnison (1985) of the similarities between Milton Erickson and Carl Rogers by citing several important differences in their respective counseling approaches. Briefly discusses implications of these differences to the continuing evolution of counseling theory and practice. (Author)

Hydrogen and advanced aerospace materials

NASA Technical Reports Server (NTRS)

Nelson, Howard G.

1988-01-01

The hydrogen embrittlement is briefly reviewed and discussed in terms of specific structural materials considered for use on a generic, hydrogen-fueled, hypersonic aerospace vehicle. A few unusual hydrogen-material incompatibility concerns are identified and some solution methodologies are discussed that could potentially lessen these concerns.

Integrated modeling: a look back

NASA Astrophysics Data System (ADS)

Briggs, Clark

2015-09-01

This paper discusses applications and implementation approaches used for integrated modeling of structural systems with optics over the past 30 years. While much of the development work focused on control system design, significant contributions were made in system modeling and computer-aided design (CAD) environments. Early work appended handmade line-of-sight models to traditional finite element models, such as the optical spacecraft concept from the ACOSS program. The IDEAS2 computational environment built in support of Space Station collected a wider variety of existing tools around a parametric database. Later, IMOS supported interferometer and large telescope mission studies at JPL with MATLAB modeling of structural dynamics, thermal analysis, and geometric optics. IMOS's predecessor was a simple FORTRAN command line interpreter for LQG controller design with additional functions that built state-space finite element models. Specialized language systems such as CAESY were formulated and prototyped to provide more complex object-oriented functions suited to control-structure interaction. A more recent example of optical modeling directly in mechanical CAD is used to illustrate possible future directions. While the value of directly posing the optical metric in system dynamics terms is well understood today, the potential payoff is illustrated briefly via project-based examples. It is quite likely that integrated structure thermal optical performance (STOP) modeling could be accomplished in a commercial off-the-shelf (COTS) tool set. The work flow could be adopted, for example, by a team developing a small high-performance optical or radio frequency (RF) instrument.

Integrated planning and scheduling for Earth science data processing

NASA Technical Reports Server (NTRS)

Boddy, Mark; White, Jim; Goldman, Robert; Short, Nick, Jr.

1995-01-01

Several current NASA programs such as the EOSDIS Core System (ECS) have data processing and data management requirements that call for an integrated planning and scheduling capability. In this paper, we describe the experience of applying advanced scheduling technology operationally, in terms of what was accomplished, lessons learned, and what remains to be done in order to achieve similar successes in ECS and other programs. We discuss the importance and benefits of advanced scheduling tools, and our progress toward realizing them, through examples and illustrations based on ECS requirements. The first part of the paper focuses on the Data Archive and Distribution (DADS) V0 Scheduler. We then discuss system integration issues ranging from communication with the scheduler to the monitoring of system events and re-scheduling in response to them. The challenge of adapting the scheduler to domain-specific features and scheduling policies is also considered. Extrapolation to the ECS domain raises issues of integrating scheduling with a product-generation planner (such as PlaSTiC), and implementing conditional planning in an operational system. We conclude by briefly noting ongoing technology development and deployment projects being undertaken by HTC and the ISTB.

Temporality and the torments of time.

PubMed

Hinton, Ladson

2015-06-01

Immersion in time gives birth to consciousness, as well as conflict and torment. When human beings developed a sense of future, they also gained the ability to anticipate threats from nature or their fellow beings. They thereby created cultures that are bastions of survival, as well as places of poetry, art and religion where they could band together and reflect upon their common plight. The practice of psychoanalysis is in many ways a temporal process, a process of remembering, for owning and elaborating a past that gives us substance, thereby providing a basis for reflective consciousness. Stimulated by Freud's early writings, Lacan, Laplanche and their successors in particular have focussed extensively on time and psychoanalysis, and their views are a central point of this discussion. A substantial case study is offered that provides concrete examples of these perspectives. A multi-faceted view of temporality emerges, one that is more syncopated than linear or teleological. In conclusion, I will briefly discuss recent findings in the neuroscience of memory and 'time travel' that underpin contemporary psychoanalytic ideas in surprising ways. It is important to remember that acceptance of the contradictory nature of temporal experience can open space for increased freedom and playfulness. © 2015, The Society of Analytical Psychology.

Exploring early public responses to geoengineering.

PubMed

Pidgeon, Nick; Corner, Adam; Parkhill, Karen; Spence, Alexa; Butler, Catherine; Poortinga, Wouter

2012-09-13

Proposals for geoengineering the Earth's climate are prime examples of emerging or 'upstream' technologies, because many aspects of their effectiveness, cost and risks are yet to be researched, and in many cases are highly uncertain. This paper contributes to the emerging debate about the social acceptability of geoengineering technologies by presenting preliminary evidence on public responses to geoengineering from two of the very first UK studies of public perceptions and responses. The discussion draws upon two datasets: qualitative data (from an interview study conducted in 42 households in 2009), and quantitative data (from a subsequent nationwide survey (n=1822) of British public opinion). Unsurprisingly, baseline awareness of geoengineering was extremely low in both cases. The data from the survey indicate that, when briefly explained to people, carbon dioxide removal approaches were preferred to solar radiation management, while significant positive correlations were also found between concern about climate change and support for different geoengineering approaches. We discuss some of the wider considerations that are likely to shape public perceptions of geoengineering as it enters the media and public sphere, and conclude that, aside from technical considerations, public perceptions are likely to prove a key element influencing the debate over questions of the acceptability of geoengineering proposals.

The lipid habitats of neurotransmitter receptors in brain.

PubMed

Borroni, María Virginia; Vallés, Ana Sofía; Barrantes, Francisco J

2016-11-01

Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signaling mechanism in the nervous system, occur either at the somatic cell surface of chemically excitable cells or at specialized subcellular structures, the synapses. Synapses have lipid compositions distinct from the rest of the cell membrane, suggesting that neurotransmitter receptors and their scaffolding and adaptor protein partners require specific lipid habitats for optimal operation. In this review we discuss some paradigmatic cases of neurotransmitter receptor-lipid interactions, highlighting the chemical nature of the intervening lipid species and providing examples of the receptor mechanisms affected by interaction with lipids. The focus is on the effects of cholesterol, glycerophospholipids and covalent fatty acid acylation on neurotransmitter receptors. We also briefly discuss the role of lipid phase states involving lateral heterogeneities of the host membrane known to modulate membrane transport, protein sorting and signaling. Modulation of neurotransmitter receptors by lipids occurs at multiple levels, affecting a wide span of activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, and recycling, among other important functional properties at the synapse. Copyright © 2016 Elsevier B.V. All rights reserved.

Text mining for search term development in systematic reviewing: A discussion of some methods and challenges.

PubMed

Stansfield, Claire; O'Mara-Eves, Alison; Thomas, James

2017-09-01

Using text mining to aid the development of database search strings for topics described by diverse terminology has potential benefits for systematic reviews; however, methods and tools for accomplishing this are poorly covered in the research methods literature. We briefly review the literature on applications of text mining for search term development for systematic reviewing. We found that the tools can be used in 5 overarching ways: improving the precision of searches; identifying search terms to improve search sensitivity; aiding the translation of search strategies across databases; searching and screening within an integrated system; and developing objectively derived search strategies. Using a case study and selected examples, we then reflect on the utility of certain technologies (term frequency-inverse document frequency and Termine, term frequency, and clustering) in improving the precision and sensitivity of searches. Challenges in using these tools are discussed. The utility of these tools is influenced by the different capabilities of the tools, the way the tools are used, and the text that is analysed. Increased awareness of how the tools perform facilitates the further development of methods for their use in systematic reviews. Copyright © 2017 John Wiley & Sons, Ltd.

An Overview of the NASA F-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Bowers, Albion H.; Pahle, Joseph W.; Wilson, R. Joseph; Flick, Bradley C.; Rood, Richard L.

1996-01-01

This paper gives an overview of the NASA F-18 High Alpha Research Vehicle. The three flight phases of the program are introduced, along with the specific goals and data examples taken during each phase. The aircraft configuration and systems needed to perform the disciplinary and inter-disciplinary research are discussed. The specific disciplines involved with the flight research are introduced, including aerodynamics, controls, propulsion, systems, and structures. Decisions that were made early in the planning of the aircraft project and the results of those decisions are briefly discussed. Each of the three flight phases corresponds to a particular aircraft configuration, and the research dictated the configuration to be flown. The first phase gathered data with the baseline F-18 configuration. The second phase was the thrust-vectoring phase. The third phase used a modified forebody with deployable nose strakes. Aircraft systems supporting these flights included extensive instrumentation systems, integrated research flight controls using flight control hardware and corresponding software, analog interface boxes to control forebody strakes, a thrust-vectoring system using external post-exit vanes around axisymmetric nozzles, a forebody vortex control system with strakes, and backup systems using battery-powered emergency systems and a spin recovery parachute.

Polymeric micelles as a new drug carrier system and their required considerations for clinical trials.

PubMed

Yokoyama, Masayuki

2010-02-01

A polymeric micelle is a macromolecular assembly composed of an inner core and an outer shell, and most typically is formed from block copolymers. In the last two decades, polymeric micelles have been actively studied as a new type of drug carrier system, in particular for drug targeting of anticancer drugs to solid tumors. In this review, polymeric micelle drug carrier systems are discussed with a focus on toxicities of the polymeric micelle carrier systems and on pharmacological activities of the block copolymers. In the first section, the importance of the above-mentioned evaluation of these properties is explained, as this importance does not seem to be well recognized compared with the importance of targeting and enhanced pharmacological activity of drugs, particularly in the basic studies. Then, designs, types and classifications of the polymeric micelle system are briefly summarized and explained, followed by a detailed discussion regarding several examples of polymeric micelle carrier systems. Readers will gain a strategy of drug delivery with polymeric carriers as well as recent progress of the polymeric micelle carrier systems in their basic studies and clinical trials. The purpose of this review is to achieve tight connections between the basic studies and clinical trials.

VUV thin films, chapter 7

NASA Technical Reports Server (NTRS)

Zukic, Muamer; Torr, Douglas G.

1993-01-01

The application of thin film technology to the vacuum ultraviolet (VUV) wavelength region from 120 nm to 230 nm has not been fully exploited in the past because of absorption effects which complicate the accurate determination of the optical functions of dielectric materials. The problem therefore reduces to that of determining the real and imaginary parts of a complex optical function, namely the frequency dependent refractive index n and extinction coefficient k. We discuss techniques for the inverse retrieval of n and k for dielectric materials at VUV wavelengths from measurements of their reflectance and transmittance. Suitable substrate and film materials are identified for application in the VUV. Such applications include coatings for the fabrication of narrow and broadband filters and beamsplitters. The availability of such devices open the VUV regime to high resolution photometry, interferometry and polarimetry both for space based and laboratory applications. This chapter deals with the optics of absorbing multilayers, the determination of the optical functions for several useful materials, and the design of VUV multilayer stacks as applied to the design of narrow and broadband reflection and transmission filters and beamsplitters. Experimental techniques are discussed briefly, and several examples of the optical functions derived for selected materials are presented.

Probing atomic Higgs-like forces at the precision frontier

NASA Astrophysics Data System (ADS)

Delaunay, Cédric; Ozeri, Roee; Perez, Gilad; Soreq, Yotam

2017-11-01

We propose a novel approach to probe new fundamental interactions using isotope shift spectroscopy in atomic clock transitions. As a concrete toy example we focus on the Higgs boson couplings to the building blocks of matter: the electron and the up and down quarks. We show that the attractive Higgs force between nuclei and their bound electrons, which is poorly constrained, might induce effects that are larger than the current experimental sensitivities. More generically, we discuss how new interactions between the electron and the neutrons, mediated via light new degrees of freedom, may lead to measurable nonlinearities in a King plot comparison between isotope shifts of two different transitions. Given state-of-the-art accuracy in frequency comparison, isotope shifts have the potential to be measured with sub-Hz accuracy, thus potentially enabling the improvement of current limits on new fundamental interactions. A candidate atomic system for this measurement requires two different clock transitions and four zero nuclear spin isotopes. We identify several systems that satisfy this requirement and also briefly discuss existing measurements. We consider the size of the effect related to the Higgs force and the requirements for it to produce an observable signal.

Laser fringe anemometry for aero engine components

NASA Technical Reports Server (NTRS)

Strazisar, A. J.

1986-01-01

Advances in flow measurement techniques in turbomachinery continue to be paced by the need to obtain detailed data for use in validating numerical predictions of the flowfield and for use in the development of empirical models for those flow features which cannot be readily modelled numerically. The use of laser anemometry in turbomachinery research has grown over the last 14 years in response to these needs. Based on past applications and current developments, this paper reviews the key issues which are involved when considering the application of laser anemometry to the measurement of turbomachinery flowfields. Aspects of laser fringe anemometer optical design which are applicable to turbomachinery research are briefly reviewed. Application problems which are common to both laser fringe anemometry (LFA) and laser transit anemometry (LTA) such as seed particle injection, optical access to the flowfield, and measurement of rotor rotational position are covered. The efficiency of various data acquisition schemes is analyzed and issues related to data integrity and error estimation are addressed. Real-time data analysis techniques aimed at capturing flow physics in real time are discussed. Finally, data reduction and analysis techniques are discussed and illustrated using examples taken from several LFA turbomachinery applications.

Apoptosis and Molecular Targeting Therapy in Cancer

PubMed Central

Hassan, Mohamed; Watari, Hidemichi; AbuAlmaaty, Ali; Ohba, Yusuke; Sakuragi, Noriaki

2014-01-01

Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. The apoptotic signals are complicated and they are regulated at several levels. The signals of carcinogenesis modulate the central control points of the apoptotic pathways, including inhibitor of apoptosis (IAP) proteins and FLICE-inhibitory protein (c-FLIP). The tumor cells may use some of several molecular mechanisms to suppress apoptosis and acquire resistance to apoptotic agents, for example, by the expression of antiapoptotic proteins such as Bcl-2 or by the downregulation or mutation of proapoptotic proteins such as BAX. In this review, we provide the main regulatory molecules that govern the main basic mechanisms, extrinsic and intrinsic, of apoptosis in normal cells. We discuss how carcinogenesis could be developed via defective apoptotic pathways or their convergence. We listed some molecules which could be targeted to stimulate apoptosis in different cancers. Together, we briefly discuss the development of some promising cancer treatment strategies which target apoptotic inhibitors including Bcl-2 family proteins, IAPs, and c-FLIP for apoptosis induction. PMID:25013758

A centennial tribute to G.K. Gilbert's Hydraulic Mining Débris in the Sierra Nevada

NASA Astrophysics Data System (ADS)

James, L. A.; Phillips, J. D.; Lecce, S. A.

2017-10-01

G.K. Gilbert's (1917) classic monograph, Hydraulic-Mining Débris in the Sierra Nevada, is described and put into the context of modern geomorphic knowledge. The emphasis here is on large-scale applied fluvial geomorphology, but other key elements-e.g., coastal geomorphology-are also briefly covered. A brief synopsis outlines key elements of the monograph, followed by discussions of highly influential aspects including the integrated watershed perspective, the extreme example of anthropogenic sedimentation, computation of a quantitative, semidistributed sediment budget, and advent of sediment-wave theory. Although Gilbert did not address concepts of equilibrium and grade in much detail, the rivers of the northwestern Sierra Nevada were highly disrupted and thrown into a condition of nonequilibrium. Therefore, concepts of equilibrium and grade-for which Gilbert's early work is often cited-are discussed. Gilbert's work is put into the context of complex nonlinear dynamics in geomorphic systems and how these concepts can be used to interpret the nonequilibrium systems described by Gilbert. Broad, basin-scale studies were common in the period, but few were as quantitative and empirically rigorous or employed such a range of methodologies as PP105. None demonstrated such an extreme case of anthropogeomorphic change.

Aerodynamics of Race Cars

NASA Astrophysics Data System (ADS)

Katz, Joseph

2006-01-01

Race car performance depends on elements such as the engine, tires, suspension, road, aerodynamics, and of course the driver. In recent years, however, vehicle aerodynamics gained increased attention, mainly due to the utilization of the negative lift (downforce) principle, yielding several important performance improvements. This review briefly explains the significance of the aerodynamic downforce and how it improves race car performance. After this short introduction various methods to generate downforce such as inverted wings, diffusers, and vortex generators are discussed. Due to the complex geometry of these vehicles, the aerodynamic interaction between the various body components is significant, resulting in vortex flows and lifting surface shapes unlike traditional airplane wings. Typical design tools such as wind tunnel testing, computational fluid dynamics, and track testing, and their relevance to race car development, are discussed as well. In spite of the tremendous progress of these design tools (due to better instrumentation, communication, and computational power), the fluid dynamic phenomenon is still highly nonlinear, and predicting the effect of a particular modification is not always trouble free. Several examples covering a wide range of vehicle shapes (e.g., from stock cars to open-wheel race cars) are presented to demonstrate this nonlinear nature of the flow field.

Bacterial cell wall composition and the influence of antibiotics by cell-wall and whole-cell NMR

PubMed Central

Romaniuk, Joseph A. H.; Cegelski, Lynette

2015-01-01

The ability to characterize bacterial cell-wall composition and structure is crucial to understanding the function of the bacterial cell wall, determining drug modes of action and developing new-generation therapeutics. Solid-state NMR has emerged as a powerful tool to quantify chemical composition and to map cell-wall architecture in bacteria and plants, even in the context of unperturbed intact whole cells. In this review, we discuss solid-state NMR approaches to define peptidoglycan composition and to characterize the modes of action of old and new antibiotics, focusing on examples in Staphylococcus aureus. We provide perspectives regarding the selected NMR strategies as we describe the exciting and still-developing cell-wall and whole-cell NMR toolkit. We also discuss specific discoveries regarding the modes of action of vancomycin analogues, including oritavancin, and briefly address the reconsideration of the killing action of β-lactam antibiotics. In such chemical genetics approaches, there is still much to be learned from perturbations enacted by cell-wall assembly inhibitors, and solid-state NMR approaches are poised to address questions of cell-wall composition and assembly in S. aureus and other organisms. PMID:26370936

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity

PubMed Central

Soldavini, Jessica

2014-01-01

Background The lumen of the gastrointestinal tract contains many substances produced from the breakdown of foodstuffs, from salivary, esophageal, intestinal, hepatic, and pancreatic secretions, and from sloughed cells present in the gastrointestinal lumen. Although these substances were traditionally regarded as waste products, there is increasing realization that many can be biologically active, either as signalling compounds or as nutrients. For example, proteins are broken down into amino acids, which are then sensed by nutrient receptors. The gut microbiome, which is at highest abundance in the ileocecum, has powerful metabolic activity, digesting and breaking down unabsorbed carbohydrates, proteins, and other ingested nutrients into phenols, amines, volatile organic compounds, methane, carbon dioxide, hydrogen, and hydrogen sulfide into volatile fatty acids, also called short-chain fatty acids (SCFAs). Conclusion These latter substances are the topic of this review. In this review, we will briefly discuss recent advances in the understanding SCFA production, signalling, and absorption, followed by a detailed description and discussion of trials of SCFAs, probiotics, and prebiotics in the treatment of gastrointestinal disease, in particular ulcerative colitis (UC), pouchitis, short bowel syndrome, and obesity. PMID:23839339

Understanding environmental contributions to autism: Causal concepts and the state of science.

PubMed

Hertz-Picciotto, Irva; Schmidt, Rebecca J; Krakowiak, Paula

2018-04-01

The complexity of neurodevelopment, the rapidity of early neurogenesis, and over 100 years of research identifying environmental influences on neurodevelopment serve as backdrop to understanding factors that influence risk and severity of autism spectrum disorder (ASD). This Keynote Lecture, delivered at the May 2016 annual meeting of the International Society for Autism Research, describes concepts of causation, outlines the trajectory of research on nongenetic factors beginning in the 1960s, and briefly reviews the current state of this science. Causal concepts are introduced, including root causes; pitfalls in interpreting time trends as clues to etiologic factors; susceptible time windows for exposure; and implications of a multi-factorial model of ASD. An historical background presents early research into the origins of ASD. The epidemiologic literature from the last fifteen years is briefly but critically reviewed for potential roles of, for example, air pollution, pesticides, plastics, prenatal vitamins, lifestyle and family factors, and maternal obstetric and metabolic conditions during her pregnancy. Three examples from the case-control CHildhood Autism Risks from Genes and the Environment Study are probed to illustrate methodological approaches to central challenges in observational studies: capturing environmental exposure; causal inference when a randomized controlled clinical trial is either unethical or infeasible; and the integration of genetic, epigenetic, and environmental influences on development. We conclude with reflections on future directions, including exposomics, new technologies, the microbiome, gene-by-environment interaction in the era of -omics, and epigenetics as the interface of those two. As the environment is malleable, this research advances the goal of a productive and fulfilling life for all children, teen-agers and adults. Autism Res 2018, 11: 554-586. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. This Keynote Lecture, delivered at the 2016 meeting of the International Society for Autism Research, discusses evidence from human epidemiologic studies of prenatal factors contributing to autism, such as pesticides, maternal nutrition and her health. There is no single cause for autism. Examples highlight the features of a high-quality epidemiology study, and what comprises a compelling case for causation. Emergent research directions hold promise for identifying potential interventions to reduce disabilities, enhance giftedness, and improve lives of those with ASD. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.

Seven R's for the Student Teacher.

ERIC Educational Resources Information Center

Newson, Graham

1983-01-01

Briefly discussed are seven qualities which provide a significant basic platform for teaching mathematics effectively: reinforcement, responsiveness, reliability, realism, reversibility, range, and radicalism. (MNS)

Benefits of Using Planned Comparisons Rather Than Post Hoc Tests: A Brief Review with Examples.

ERIC Educational Resources Information Center

DuRapau, Theresa M.

The rationale behind analysis of variance (including analysis of covariance and multiple analyses of variance and covariance) methods is reviewed, and unplanned and planned methods of evaluating differences between means are briefly described. Two advantages of using planned or a priori tests over unplanned or post hoc tests are presented. In…

Harry Truman and the Atomic Bomb: An Excursion into Character Education through Storytelling

ERIC Educational Resources Information Center

Sanchez, Tony R.

2006-01-01

This article asserts the importance of character education through the utilization of historical storytelling in the social studies classroom. After briefly noting the value of the historical story in this regard, a specific, ready-made example is provided concerning Truman's decision to use the atomic bomb and includes a crucial set of follow-up…

GeoGebra for Mathematical Statistics

ERIC Educational Resources Information Center

Hewson, Paul

2009-01-01

The GeoGebra software is attracting a lot of interest in the mathematical community, consequently there is a wide range of experience and resources to help use this application. This article briefly outlines how GeoGebra will be of great value in statistical education. The release of GeoGebra is an excellent example of the power of free software…

Materials for optical memory: Resolved hyperfine structure in KY3F10:Ho3+

NASA Astrophysics Data System (ADS)

Popova, M. N.

2013-08-01

Basic principles of creating a quantum optical memory (QOM) and requirements for relevant materials, in particular, for crystals doped with rare-earth ions, are briefly reviewed. A combined approach to studying the hyperfine structure, which is essential for QOM applications, is presented on the example of KY3F10:Ho3+.

Can metaphysical values protect mountain wildlands from development damage?

Treesearch

Lawrence S. Hamilton; Jeneda Benally

2015-01-01

This paper addresses the question of whether spiritual, religious or cultural values held by humans for some wild mountain areas can protect these special places from developments that impair both these values and wild nature. The answer is sometimes yes, sometimes no, and sometimes a minimization of damage. Examples of each of these scenarios are briefly given, along...

CoSN K12 Open Technologies Implementation Study #3. Moodle: An Open Learning Content Management System for Schools

ERIC Educational Resources Information Center

Consortium for School Networking (NJ1), 2008

2008-01-01

This report introduces educators to Moodle, an open-source software program for managing courses online. It briefly defines what Moodle is, what it can do, and gives specific examples of how it is being implemented. An appendix contains brief profiles of five school organizations that are using Moodle.

The Economics of the Commodity Market Operations.

DTIC Science & Technology

1986-06-01

32 D. HEDGING ........................................................................ 33 E. SPECULATING...Result of Chernobyl’s Nuclear Accident ........................................... 49 It. e -Mr i7s0 I LIST OF FIGURES *4. 1. Example of a Perfect Hedge ...briefly. The reason for this is the power of arbitrage . Arbitrage is the simultaneous purchase of a futures contract in one market against the sale

Glossary of Water Resources Terms. Taft Campus Occasional Paper No. X.

ERIC Educational Resources Information Center

Vogl, Robert; Vogl, Sonia

A product of the Department of Outdoor Teacher Education Program at Northern Illinois University, this glossary of water resources terms includes 87 briefly defined entries. Examples of the terms and definitions presented are: Acidity (presence of acids in the water which produce a pH below seven); Bathymetry (study of lake bottom contours);…

Post-earthquake dilatancy recovery

NASA Technical Reports Server (NTRS)

Scholz, C. H.

1974-01-01

Geodetic measurements of the 1964 Niigata, Japan earthquake and of three other examples are briefly examined. They show exponentially decaying subsidence for a year after the quakes. The observations confirm the dilatancy-fluid diffusion model of earthquake precursors and clarify the extent and properties of the dilatant zone. An analysis using one-dimensional consolidation theory is included which agrees well with this interpretation.

Application of the Localisation Platform Crowdin in Translator Education

ERIC Educational Resources Information Center

Kudla, Dominik

2017-01-01

This article is an attempt to briefly describe the potential of the online localisation platform Crowdin for the education of the future translators at universities and in private courses or workshops. This description is provided on the basis of the information gathered through the user experience of the author and uses the example of the Khan…

Algorithmic formulation of control problems in manipulation

NASA Technical Reports Server (NTRS)

Bejczy, A. K.

1975-01-01

The basic characteristics of manipulator control algorithms are discussed. The state of the art in the development of manipulator control algorithms is briefly reviewed. Different end-point control techniques are described together with control algorithms which operate on external sensor (imaging, proximity, tactile, and torque/force) signals in realtime. Manipulator control development at JPL is briefly described and illustrated with several figures. The JPL work pays special attention to the front or operator input end of the control algorithms.

Studies in the extensively automatic construction of large odds-based inference networks from structured data. Examples from medical, bioinformatics, and health insurance claims data.

PubMed

Robson, B; Boray, S

2018-04-01

Theoretical and methodological principles are presented for the construction of very large inference nets for odds calculations, composed of hundreds or many thousands or more of elements, in this paper generated by structured data mining. It is argued that the usual small inference nets can sometimes represent rather simple, arbitrary estimates. Examples of applications in clinical and public health data analysis, medical claims data and detection of irregular entries, and bioinformatics data, are presented. Construction of large nets benefits from application of a theory of expected information for sparse data and the Dirac notation and algebra. The extent to which these are important here is briefly discussed. Purposes of the study include (a) exploration of the properties of large inference nets and a perturbation and tacit conditionality models, (b) using these to propose simpler models including one that a physician could use routinely, analogous to a "risk score", (c) examination of the merit of describing optimal performance in a single measure that combines accuracy, specificity, and sensitivity in place of a ROC curve, and (d) relationship to methods for detecting anomalous and potentially fraudulent data. Copyright © 2018 Elsevier Ltd. All rights reserved.

Setting research priorities by applying the combined approach matrix.

PubMed

Ghaffar, Abdul

2009-04-01

Priority setting in health research is a dynamic process. Different organizations and institutes have been working in the field of research priority setting for many years. In 1999 the Global Forum for Health Research presented a research priority setting tool called the Combined Approach Matrix or CAM. Since its development, the CAM has been successfully applied to set research priorities for diseases, conditions and programmes at global, regional and national levels. This paper briefly explains the CAM methodology and how it could be applied in different settings, giving examples and describing challenges encountered in the process of setting research priorities and providing recommendations for further work in this field. The construct and design of the CAM is explained along with different steps needed, including planning and organization of a priority-setting exercise and how it could be applied in different settings. The application of the CAM are described by using three examples. The first concerns setting research priorities for a global programme, the second describes application at the country level and the third setting research priorities for diseases. Effective application of the CAM in different and diverse environments proves its utility as a tool for setting research priorities. Potential challenges encountered in the process of research priority setting are discussed and some recommendations for further work in this field are provided.

The Indian Media Scenario.

ERIC Educational Resources Information Center

Eapen, K. E.

As background information for a discussion of India's communication system and its potential for social change, this paper briefly describes the country's physical characteristics, some of its cultural heritage and demographics, and the development of its education and railways. After a discussion of the folk media (traditional changes) of…

Report on phase 2 of 1990 OSSA data census

NASA Technical Reports Server (NTRS)

King, Joseph H.

1991-01-01

The 1990 NASA Office of Space Science and Applications (OSSA) data census contributed significantly to a database intended to identify and briefly describe all archived data and potentially archive-desirable data from active and inactive NASA/OSSA spaceflight investigations. This database is being created at the National Space Science Data Center (NSSDC) and will be more comprehensive than the databases describing data held at individual sites such as NSSDC. Active investigations are defined as those flying on currently operational spacecraft or those that flew on recently operational spacecraft for which project-coordinated data archiving is continuing. Inactive investigations are those that flew on spacecraft that are no longer operational, and for which systematic archiving has ended. The principal purpose of this report is to describe phase two of the 1990 census. The previously reported phase one of this census, as well as a relevant 1981 census, are briefly discussed. The phase two survey instrument is described, those surveyed and respondents/reponses are identified, and data sets from inactive OSSA investigations discovered during the 1990 census (phase two) are briefly discussed individually.

A Comparative Study of Educational Environments of Preschool Children in Japan and Israel.

ERIC Educational Resources Information Center

Ishigaki, Emiko Hannah

This brief discussion and report of research considers aspects of culture and religion and their influence on young children in Japan and Israel. The discussion of Japan traces the development of early childhood education from the beginning of the modern era to 1985. The discussion of Israel briefly traces population characteristics and…

Continuous renal replacement therapies: a brief primer for the neurointensivist.

PubMed

Patel, Pritesh; Nandwani, Veena; McCarthy, Paul J; Conrad, Steven A; Keith Scott, L

2010-10-01

Continuous renal replacement therapy (CRRT) is a renal replacement modality that is often used in the ICU setting, including the neuro-ICU. This form of renal replacement therapy has been used classically for acute renal failure in patients with hemodynamic compromise, but is gaining acceptance as a method to control vascular and extra-vascular volume and mediate cytokines in non-renal diseases. Although these uses are briefly discussed, this review concentrates on the different forms of continuous renal replacement, mainly focusing on the technology of convective versus diffusive modalities and briefly on filter technology. There is also discussion on the various anticoagulation regimes used in CRRT including data on performing CRRT without anticoagulation. This review is not meant to be a discussion on the pros and cons of CRRT versus intermittent dialysis, but rather a primer on the technology of CRRT and how this therapy may affect general care of the ICU patient.

Mathematical Geology.

ERIC Educational Resources Information Center

Jones, Thomas A.

1983-01-01

Mathematical techniques used to solve geological problems are briefly discussed (including comments on use of geostatistics). Highlights of conferences/meetings and conference papers in mathematical geology are also provided. (JN)

Nuclear power supplies: Their potential and the practical problems to their achievement for space missions

NASA Technical Reports Server (NTRS)

Colston, B. W.

1986-01-01

Various issues associated with getting technology development of nuclear power systems moving at a pace which will support the anticipated need for such systems in later years is discussed. The projected power needs of such advanced space elements as growth space stations and lunar and planetary vehicles and bases are addressed briefly, and the relevance of nuclear power systems is discussed. A brief history and status of the U.S. nuclear reactor systems is provided, and some of the problems (real and/or perceived) are dealt with briefly. Key areas on which development attention should be focused in the near future are identified, and a suggested approach is recommended to help accelerate the process.

Marketing Continuing Education for Nurses.

ERIC Educational Resources Information Center

Southern Regional Education Board, Atlanta, GA.

This guide presents an overview of marketing and its potential value in continuing education programs for nurses. The first portion of the guide briefly discusses the concept of marketing. It contains definitions of key marketing concepts (product, place, price, and promotion), discussion of the basic tenets of marketing (consumer needs…

Children in Contemporary Society: Child Ecology.

ERIC Educational Resources Information Center

Frank, Mary, Ed.

This collection of short articles focuses on various dimensions of childhood ecology. Section I introduces a conceptual framework for the study of childhood ecology and poses 4 methodological principles for human development specialists. Four ecological subsystems are identified and discussed briefly. Section II discusses the family microsystem in…

Intellectual Property Law and the Protection of Computer Programs.

ERIC Educational Resources Information Center

Lomio, J. Paul

1990-01-01

Briefly reviews the laws pertaining to copyrights, patents, and trade secrets, and discusses how each of these may be applied to the protection of computer programs. The comparative merits and limitations of each category of law are discussed and recent court decisions are summarized. (CLB)

How neuroscience might advance the law.

PubMed Central

O'Hara, Erin Ann

2004-01-01

This essay discusses the strengths and limitations of the new, growing field of law and biology and suggests that advancements in neuroscience can help to bolster that field. It also briefly discusses some ways that neuroscience can help to improve the workings of law more generally. PMID:15590609

High Power Laser Safety

NASA Astrophysics Data System (ADS)

Brusl, Helmut

1986-10-01

The Austrian legislation about laser safety is discussed. Appropriate control measures for laser use and alternate means of enclosure and baffling are presented. Present laser safety standards are explained briefly. Eye protective techniques and eyewear are considered for a variety of sources. The optical properties of enclosure materials are also discussed.

Improving Classroom Behavior: The Carrot and the Stick.

ERIC Educational Resources Information Center

Talent, Barbara K.; Busch, Suzanne G.

A set of practical behavior change techniques for improving young children's classroom behavior are briefly discussed. Techniques are classified and discussed under two general categories: those that reduce frequency of behaviors ("sticks") and those that increase their frequency ("carrots"). Included under "sticks" are techniques such as ignoring…

Simulation in Metallurgical Processing: Recent Developments and Future Perspectives

NASA Astrophysics Data System (ADS)

Ludwig, Andreas; Wu, Menghuai; Kharicha, Abdellah

2016-08-01

This article briefly addresses the most important topics concerning numerical simulation of metallurgical processes, namely, multiphase issues (particle and bubble motion and flotation/sedimentation of equiaxed crystals during solidification), multiphysics issues (electromagnetic stirring, electro-slag remelting, Cu-electro-refining, fluid-structure interaction, and mushy zone deformation), process simulations on graphical processing units, integrated computational materials engineering, and automatic optimization via simulation. The present state-of-the-art as well as requirements for future developments are presented and briefly discussed.

Assembling a Space Station in orbit

NASA Technical Reports Server (NTRS)

Brand, Vance D.; Lounge, J. Michael; Walker, David M.

1990-01-01

The factors affecting the degree of difficulty of assembling a Space Station in orbit and ways of arriving at the optimum construction solution are briefly reviewed and applied to the Space Station Freedom (SSF). The assembly of the SSF navigation and control systems and the relevant tools and methods are examined along with the characteristics of early assembly flights. The most significant challenges facing the construction of the SSF are discussed, and new technologies which will be incorporated into the SSF are briefly considered.

Focus on Statistical Physics Modeling in Economics and Finance

NASA Astrophysics Data System (ADS)

Mantegna, Rosario N.; Kertész, János

2011-02-01

This focus issue presents a collection of papers on recent results in statistical physics modeling in economics and finance, commonly known as econophysics. We touch briefly on the history of this relatively new multi-disciplinary field, summarize the motivations behind its emergence and try to characterize its specific features. We point out some research aspects that must be improved and briefly discuss the topics the research field is moving toward. Finally, we give a short account of the papers collected in this issue.

Modelling the Burstiness of Complex Space Plasmas Using Linear Fractional Stable Motion

NASA Astrophysics Data System (ADS)

Watkins, N. W.; Rosenberg, S. J.; Chapman, S. C.; Sanchez, R.; Credgington, D.

2009-12-01

The Earth's magnetosphere is quite clearly “complex" in the everyday sense of the word. However, in the last 15 to 20 years there has been a growing thread in space physics (e.g. Freeman & Watkins [Science, 2002] , Chapman & Watkins [Space Science Reviews, 2001]) using and developing some of the emerging science of complex systems (e.g. Sornette, 2nd Edition, 2004). A particularly well-studied set of system properties has been derived from those used in the study of critical phenomena, notably correlation functions, power spectra, distributions of bursts above a threshold, and so on (e.g. Watkins [Nonlinear Processes in Geophysics, 2002]). These have revealed behaviours familiar from many other complex systems, such as burstiness, long range dependence, heavy tailed probability distributions and so forth. The results of these studies are typically interpreted within existing paradigms, most notably self-organised criticality. However, just as in other developing areas of complexity science (Sornette, op. cit.; Watkins & Freeman [Science, 2008]), it is increasingly being realised that the diagnostics in use have not been extensively studied outside the context in which they were originally proposed. This means that, for example, it is not well established what the expected distribution of bursts above a fixed threshold will be for time series other than Brownian (or fractional Brownian) motion. We will describe some preliminary investigations (Watkins et al [Physical Review E, 2009]) into the burst distribution problem, using Linear Fractional Stable Motion as a controllable toy model of a process exhibiting both long-range dependence and heavy tails. A by product of the work was a differential equation for LFSM (Watkins et al, op cit), which we also briefly discuss. Current and future work will also focus on the thorny problem of distinguishing turbulence from SOC in natural datasets (Watkins et al; Uritsky et al [Physical Review Letters, 2009]) with limited dynamic range, an area which will also be briefly discussed.

Wind loading on solar concentrators: some general considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roschke, E. J.

A survey has been completed to examine the problems and complications arising from wind loading on solar concentrators. Wind loading is site specific and has an important bearing on the design, cost, performance, operation and maintenance, safety, survival, and replacement of solar collecting systems. Emphasis herein is on paraboloidal, two-axis tracking systems. Thermal receiver problems also are discussed. Wind characteristics are discussed from a general point of view; current methods for determining design wind speed are reviewed. Aerodynamic coefficients are defined and illustrative examples are presented. Wind tunnel testing is discussed, and environmental wind tunnels are reviewed; recent results onmore » heliostat arrays are reviewed as well. Aeroelasticity in relation to structural design is discussed briefly. Wind loads, i.e., forces and moments, are proportional to the square of the mean wind velocity. Forces are proportional to the square of concentrator diameter, and moments are proportional to the cube of diameter. Thus, wind loads have an important bearing on size selection from both cost and performance standpoints. It is concluded that sufficient information exists so that reasonably accurate predictions of wind loading are possible for a given paraboloidal concentrator configuration, provided that reliable and relevant wind conditions are specified. Such predictions will be useful to the design engineer and to the systems engineer as well. Information is lacking, however, on wind effects in field arrays of paraboloidal concentrators. Wind tunnel tests have been performed on model heliostat arrays, but there are important aerodynamic differences between heliostats and paraboloidal dishes.« less

"How Science Works" and Data Logging: Eleven Quick Experiments with a Kettle

ERIC Educational Resources Information Center

Walker, Justin

2010-01-01

The benefits of using data logging to teach "how science works" are presented. Pedagogical approaches that take advantage of other school ICT are briefly described. A series of simple, quick experiments are given together with their resulting charts. Examples of the questions that arise from the charts show how the rich data lead to the refinement…

Brief Pictorial Description of New Mobile Technologies Used in Cultural Institutions in Japan

ERIC Educational Resources Information Center

Awano, Yumi

2007-01-01

Many Japanese museums and other cultural institutions have been exploring ways to enrich visitors' experiences using new digital devices. This paper briefly describes some examples in Japan, ranging from a PDA, a mobile phone, podcasting, and an audio guide speaker-equipped vest to a Quick Response (QR) code on a brochure for downloading a short…

Playground Physics: Determining the Moment of Inertia of a Merry-Go-Round

ERIC Educational Resources Information Center

Van Hook, Stephen; Lark, Adam; Hodges, Jeff; Celebrezze, Eric; Channels, Lindsey

2007-01-01

A playground can provide a valuable physics education laboratory. For example, Taylor et al. describe bringing teachers in a workshop to a playground to examine the physics of a seesaw and slide, and briefly suggest experiments involving a merry-go-round. In this paper, we describe an experiment performed by students from a Society of Physics…

[Trichoma (Plica polonica) - a contemporary case with a historical disease].

PubMed

Wolf, Florian; Scherr, Martin; Scherthöffer, Dirk; Bäuml, Josef; Förstl, Hans

2008-01-01

We describe a 62-year-old patient with a chronic delusional disorder who presented with severely matted hair ("plica polonica"). Until the late 19th century such dreadlocks were considered as cause, consequence and treatment of mental disease. The historical development of "plica polonica" is briefly reviewed as an example of early and once popular psychiatric disease concepts.

The Center for Collegiate Mental Health: An Example of a Practice-Research Network in University Counseling Centers

ERIC Educational Resources Information Center

Castonguay, Louis G.; Locke, Benjamin D.; Hayes, Jeffrey A.

2011-01-01

This article presents a model of a practice-research network that offers benefits for clinicians working at college and university counseling centers. We briefly describe the basic components of this practice-research network, challenges in developing it, and some of the empirical studies that have resulted from this initiative. We also describe…

The use of DFDR information in the analysis of a turbulence incident over Greenland

NASA Technical Reports Server (NTRS)

Lester, Peter F.; Sen, Orhan; Bach, R. E., Jr.

1989-01-01

Digital flight data recorder (DFDR) tapes from commercial aircraft can provide useful information about the mesoscale environment of severe turbulence incidents. Air motion computations from these data and their errors are briefly described. An example of mesoscale meteorological information available from DFDR tapes is presented for a case of turbulence in mountain waves over the Greenland icecap.

Identification, rearing, and distribution of stick insects of Madeira Island: an example of raising biodiversity awareness.

PubMed

Aguiar, António M F; Pombo, Dora Aguin; Gonçalves, Ysabel M

2014-04-10

Two species of stick insects are currently known to be present in the Macaronesian archipelagos: Clonopsis gallica (Charpentier) (Phasmatodea: Bacillidae) on the Canary Islands and in the Azores and Carausius morosus (Sinéty) (Phasmatidae) in the Azores. Here, we provide the first reliable records of the presence and distribution of C. gallica and C. morosus on Madeira Island. Egg and adult stages are briefly described along with some notes on the life history of these species in captivity. Data on islandwide distribution are based on specimens donated by the public in response to an article published in a daily newspaper. This method of data collection raised great popular interest in stick insects. The role of newspapers as a means of communicating awareness in biodiversity issues is discussed. This is an open access paper. We use the Creative Commons Attribution 3.0 license that permits unrestricted use, provided that the paper is properly attributed.

Plastics and health risks.

PubMed

Halden, Rolf U

2010-01-01

By 2010, the worldwide annual production of plastics will surpass 300 million tons. Plastics are indispensable materials in modern society, and many products manufactured from plastics are a boon to public health (e.g., disposable syringes, intravenous bags). However, plastics also pose health risks. Of principal concern are endocrine-disrupting properties, as triggered for example by bisphenol A and di-(2-ethylhexyl) phthalate (DEHP). Opinions on the safety of plastics vary widely, and despite more than five decades of research, scientific consensus on product safety is still elusive. This literature review summarizes information from more than 120 peer-reviewed publications on health effects of plastics and plasticizers in lab animals and humans. It examines problematic exposures of susceptible populations and also briefly summarizes adverse environmental impacts from plastic pollution. Ongoing efforts to steer human society toward resource conservation and sustainable consumption are discussed, including the concept of the 5 Rs--i.e., reduce, reuse, recycle, rethink, restrain--for minimizing pre- and postnatal exposures to potentially harmful components of plastics.

Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives.

PubMed

Gao, Meng; Tang, Ben Zhong

2017-10-27

Fluorescent sensors with advantages of excellent sensitivity, rapid response, and easy operation are emerging as powerful tools in environmental monitoring, biological research, and disease diagnosis. However, conventional fluorophores featured with π-planar structures usually suffer from serious self-quenching in the aggregated state, poor photostability, and small Stokes' shift. In contrast to conventional aggregation-caused quenching (ACQ) fluorophores, the newly emerged aggregation-induced emission fluorogens (AIEgens) are featured with high emission efficiency in the aggregated state, which provide unique opportunities for various sensing applications with advantages of high signal-to-noise ratio, strong photostability, and large Stokes' shift. In this review, we will first briefly give an introduction of the AIE concept and the turn-on sensing principles. Then, we will discuss the recent examples of AIE sensors according to types of analytes. Finally, we will give a perspective on the future developments of AIE sensors. We hope this review will inspire more endeavors to devote to this emerging world.

Optimization of insect cell based protein production processes - online monitoring, expression systems, scale up.

PubMed

Druzinec, Damir; Salzig, Denise; Brix, Alexander; Kraume, Matthias; Vilcinskas, Andreas; Kollewe, Christian; Czermak, Peter

2013-01-01

Due to the increasing use of insect cell based expression systems in research and industrial recombinant protein production, the development of efficient and reproducible production processes remains a challenging task. In this context, the application of online monitoring techniques is intended to ensure high and reproducible product qualities already during the early phases of process development. In the following chapter, the most common transient and stable insect cell based expression systems are briefly introduced. Novel applications of insect cell based expression systems for the production of insect derived antimicrobial peptides/proteins (AMPs) are discussed using the example of G. mellonella derived gloverin. Suitable in situ sensor techniques for insect cell culture monitoring in disposable and common bioreactor systems are outlined with respect to optical and capacitive sensor concepts. Since scale up of production processes is one of the most critical steps in process development, a conclusive overview is given about scale up aspects for industrial insect cell culture processes.

Implementation of ISO 10110 optics drawing standards for the National Ignition Facility

NASA Astrophysics Data System (ADS)

Wang, David Y.; English, R. Edward, Jr.; Aikens, David M.

1999-11-01

The National Ignition Facility (NIF) project elected to implement ISO 10110 standard for the specifications of NIF optics drawings in 1996. More than 7,000 NIF large optics and 20,000 NIF small optics will be manufactured based on ISO 10110 indications. ISO 10110 standard meets many of the needs of the NIF optics specifications. It allows the optical engineer to quantify and clearly communicate the desired optical specifications. While no single drawing standard specifies all the requirements of high energy laser system, a combination of ISO 10110 standard with detailed notes make it possible to apply international drawing standards to the NIF laser system. This paper will briefly describe LLNL's interpretation and implementation of the ISO 10110 drawing standard, present some examples of NIF optics drawings, and discuss pros and cons of the indications from the perspective of this application. Emphasis will be given to the surface imperfection specifications, known as 5/, for the NIF optics.

Solar Photovoltaic DC Systems: Basics and Safety: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

McNutt, Peter F; Sekulic, William R; Dreifuerst, Gary

Solar Photovoltaic (PV) systems are common and growing with 42.4 GW installed capacity in U.S. (almost 15 GW added in 2016). This paper will help electrical workers, and emergency responders understand the basic operating principles and hazards of PV DC arrays. We briefly discuss the following aspects of solar photovoltaic (PV) DC systems: the effects of solar radiation and temperature on output power; PV module testing standards; common system configurations; a simple PV array sizing example; NEC guidelines and other safety features; DC array commissioning, periodic maintenance and testing; arc-flash hazard potential; how electrical workers and emergency responders can andmore » do work safely around PV arrays; do moonlight and artificial lighting pose a real danger; typical safe operating procedures; and other potential DC-system hazards to be aware of. We also present some statistics on PV DC array electrical incidents and injuries. Safe PV array operation is possible with a good understanding of PV DC arrays basics and having good safe operating procedures in place.« less

Helminth parasitic infections of the central nervous system: a diagnostic approach.

PubMed

Othman, Ahmad A; Bruschi, Fabrizio; Ganna, Ahmed A

2014-04-01

Helminth parasitic infections of the central nervous system (CNS) occur worldwide with high prevalence in tropical and subtropical countries. Clinical evaluation of patients is mandatory, and it is convenient to group the clinical manifestations into syndromes: for example space-occupying lesions, meningitis, and encephalitis. The history should focus on residence or travel to endemic areas, diet, activities, intercurrent medical conditions, and associated clinical clues. Direct parasitological diagnosis can be reached by cerebrospinal fluid and cerebral tissue examination either by microscopy, culture, or immunological techniques. Immunodiagnosis by detection of parasite antibodies or antigens in serum could provide indirect evidence of parasitic infections. In addition, various imaging and radiological techniques e.g., computed tomography (CT) scan and magnetic resonance imaging (MRI) complement the diagnostic work-up of CNS diseases. Finally, the helminthic CNS infections of global impact, such as schistosomiasis, neurotoxocariasis, Strongyloides infection, neurotrichinosis, neurocysticercosis, and echinococcosis will be briefly discussed as regards the principal clinical and diagnostic features.

Art and cartography as a critique of borders

NASA Astrophysics Data System (ADS)

Melo Ribeiro, Daniel

2018-05-01

This study focuses on the relationship between art and cartography. The main objective is to analyze how contemporary art uses maps to criticize borders. Inspired by the arguments raised by the Critical Cartography against the false neutrality of maps, we emphasize the potential of artworks to communicate different insights about how we experience and live the contemporary space. In that sense, art plays an important role not only to discuss the articulation of power and knowledge in cartography, but also to propose other categories of thought. Considering that borders are one of the most relevant visual elements on a map, we propose the following question: how the intersection between art and cartography can improve the critical thinking about borders? By questioning borders, art underlines that physical world is characterized by liminal spaces, not by absolute or strict separations. We briefly analyzed some examples of artworks that deal with political issues regarding this topic. Our findings suggest that art could reveal the impact of imposing borders in a space, whose arbitrary delimitation reflects power relations.

Molecular Biosensors for Electrochemical Detection of Infectious Pathogens in Liquid Biopsies: Current Trends and Challenges

PubMed Central

Yáñez-Sedeño, Paloma

2017-01-01

Rapid and reliable diagnosis of infectious diseases caused by pathogens, and timely initiation of appropriate treatment are critical determinants to promote optimal clinical outcomes and general public health. Conventional in vitro diagnostics for infectious diseases are time-consuming and require centralized laboratories, experienced personnel and bulky equipment. Recent advances in electrochemical affinity biosensors have demonstrated to surpass conventional standards in regards to time, simplicity, accuracy and cost in this field. The tremendous potential offered by electrochemical affinity biosensors to detect on-site infectious pathogens at clinically relevant levels in scarcely treated body fluids is clearly stated in this review. The development and application of selected examples using different specific receptors, assay formats and electrochemical approaches focusing on the determination of specific circulating biomarkers of different molecular (genetic, regulatory and functional) levels associated with bacterial and viral pathogens are critically discussed. Existing challenges still to be addressed and future directions in this rapidly advancing and highly interesting field are also briefly pointed out. PMID:29099764

Designing proteins to combat disease: Cardiac troponin C as an example.

PubMed

Davis, Jonathan P; Shettigar, Vikram; Tikunova, Svetlana B; Little, Sean C; Liu, Bin; Siddiqui, Jalal K; Janssen, Paul M L; Ziolo, Mark T; Walton, Shane D

2016-07-01

Throughout history, muscle research has led to numerous scientific breakthroughs that have brought insight to a more general understanding of all biological processes. Potentially one of the most influential discoveries was the role of the second messenger calcium and its myriad of handling and sensing systems that mechanistically control muscle contraction. In this review we will briefly discuss the significance of calcium as a universal second messenger along with some of the most common calcium binding motifs in proteins, focusing on the EF-hand. We will also describe some of our approaches to rationally design calcium binding proteins to palliate, or potentially even cure cardiovascular disease. Considering not all failing hearts have the same etiology, genetic background and co-morbidities, personalized therapies will need to be developed. We predict designer proteins will open doors for unprecedented personalized, and potentially, even generalized medicines as gene therapy or protein delivery techniques come to fruition. Copyright © 2016 Elsevier Inc. All rights reserved.

Metadata: Standards for Retrieving WWW Documents (and Other Digitized and Non-Digitized Resources)

NASA Astrophysics Data System (ADS)

Rusch-Feja, Diann

The use of metadata for indexing digitized and non-digitized resources for resource discovery in a networked environment is being increasingly implemented all over the world. Greater precision is achieved using metadata than relying on universal search engines and furthermore, meta-data can be used as filtering mechanisms for search results. An overview of various metadata sets is given, followed by a more focussed presentation of Dublin Core Metadata including examples of sub-elements and qualifiers. Especially the use of the Dublin Core Relation element provides connections between the metadata of various related electronic resources, as well as the metadata for physical, non-digitized resources. This facilitates more comprehensive search results without losing precision and brings together different genres of information which would otherwise be only searchable in separate databases. Furthermore, the advantages of Dublin Core Metadata in comparison with library cataloging and the use of universal search engines are discussed briefly, followed by a listing of types of implementation of Dublin Core Metadata.

Neural-Net Processed Characteristic Patterns for Measurement of Structural Integrity of Pressure Cycled Components

NASA Technical Reports Server (NTRS)

Decker, A. J.

2001-01-01

A neural-net inspection process has been combined with a bootstrap training procedure and electronic holography to detect changes or damage in a pressure-cycled International Space Station cold plate to be used for cooling instrumentation. The cold plate was excited to vibrate in a normal mode at low amplitude, and the neural net was trained by example to flag small changes in the mode shape. The NDE (nondestructive-evaluation) technique is straightforward but in its infancy; its applications are ad-hoc and uncalibrated. Nevertheless previous research has shown that the neural net can detect displacement changes to better than 1/100 the maximum displacement amplitude. Development efforts that support the NDE technique are mentioned briefly, followed by descriptions of electronic holography and neural-net processing. The bootstrap training procedure and its application to detection of damage in a pressure-cycled cold plate are discussed. Suggestions for calibrating and quantifying the NDE procedure are presented.

Frequency stabilization in injection controlled pulsed CO2 lasers

NASA Technical Reports Server (NTRS)

Menzies, Robert T.; Ancellet, Gerard M.

1987-01-01

Longitudinal mode selection by injection has been demonstrated as a viable technique for tailoring a TEA-CO2 laser with pulse energies of a Joule or greater to fit the requirements of a coherent lidar transmitter. Once reliable generation of single-longitudinal-mode (SLM) pulses is obtained, one can study the intrapulse frequency variation and attempt to determine the sources of frequency sweeping, or chirp. These sources include the effect of the decaying plasma, the thermal gradient due to the energy dissipation associated with the laser mechanism itself, and the pressure shift of the center frequency of the laser transition. The use of the positive-branch unstable resonator as an efficient means of coupling a discharge with transverse spatial dimensions of the order of centimeters to an optical cavity mode introduces another concern: namely, what can be done to emphasize transverse mode discrimination in an unstable resonator cavity while maintaining high coupling efficiency. These issues are briefly discussed in the paper, and representative experimental examples are included.

From dark to bright: novel daylighting applications in solid state lighting

NASA Astrophysics Data System (ADS)

Adler, Helmar G.

2011-10-01

The term "daylighting" is used in various ways, on one hand in a more architectural sense, i.e. using existing daylight to illuminate spaces, and on the other, more recently, for using light sources to replicate daylight. The emergence of solid state lighting (SSL) opens up a large number of new avenues for daylighting. SSL allows innovative controllability of intensity and color for artificial light sources that can be advantageously applied to daylighting. With the assistance of these new technologies the combination of natural and artificial lighting could lead to improvements in energy savings and comfort of living beings. Thus it is imperative to revisit or even improve daylighting research so that building networks of the future with their sensor, energy (e.g. HVAC) and lighting requirements can benefit from the emerging capabilities. This paper will briefly review existing daylighting concepts and technology and discuss new ideas. An example of a tunable multi-color SSL system will be shown.

Small RNA biology is systems biology.

PubMed

Jost, Daniel; Nowojewski, Andrzej; Levine, Erel

2011-01-01

During the last decade small regulatory RNA (srRNA) emerged as central players in the regulation of gene expression in all kingdoms of life. Multiple pathways for srRNA biogenesis and diverse mechanisms of gene regulation may indicate that srRNA regulation evolved independently multiple times. However, small RNA pathways share numerous properties, including the ability of a single srRNA to regulate multiple targets. Some of the mechanisms of gene regulation by srRNAs have significant effect on the abundance of free srRNAs that are ready to interact with new targets. This results in indirect interactions among seemingly unrelated genes, as well as in a crosstalk between different srRNA pathways. Here we briefly review and compare the major srRNA pathways, and argue that the impact of srRNA is always at the system level. We demonstrate how a simple mathematical model can ease the discussion of governing principles. To demonstrate these points we review a few examples from bacteria and animals.

Towards pump-probe experiments of defect dynamics with short ion beam pulses

NASA Astrophysics Data System (ADS)

Schenkel, T.; Lidia, S. M.; Weis, C. D.; Waldron, W. L.; Schwartz, J.; Minor, A. M.; Hosemann, P.; Kwan, J. W.

2013-11-01

A novel, induction type linear accelerator, the Neutralized Drift Compression eXperiment (NDCX-II), is currently being commissioned at Berkeley Lab. This accelerator is designed to deliver intense (up to 3 × 1011 ions/pulse), 0.6 to ∼600 ns duration pulses of 0.05-1.2 MeV lithium ions at a rate of about 2 pulses per minute onto 1-10 mm scale target areas. When focused to mm-diameter spots, the beam is predicted to volumetrically heat micrometer thick foils to temperatures of ∼30,000 °K. At lower beam power densities, the short excitation pulse with tunable intensity and time profile enables pump-probe type studies of defect dynamics in a broad range of materials. We briefly describe the accelerator concept and design, present results from beam pulse shaping experiments and discuss examples of pump-probe type studies of defect dynamics following irradiation of materials with intense, short ion beam pulses from NDCX-II.

Droplet based microfluidics.

PubMed

Seemann, Ralf; Brinkmann, Martin; Pfohl, Thomas; Herminghaus, Stephan

2012-01-01

Droplet based microfluidics is a rapidly growing interdisciplinary field of research combining soft matter physics, biochemistry and microsystems engineering. Its applications range from fast analytical systems or the synthesis of advanced materials to protein crystallization and biological assays for living cells. Precise control of droplet volumes and reliable manipulation of individual droplets such as coalescence, mixing of their contents, and sorting in combination with fast analysis tools allow us to perform chemical reactions inside the droplets under defined conditions. In this paper, we will review available drop generation and manipulation techniques. The main focus of this review is not to be comprehensive and explain all techniques in great detail but to identify and shed light on similarities and underlying physical principles. Since geometry and wetting properties of the microfluidic channels are crucial factors for droplet generation, we also briefly describe typical device fabrication methods in droplet based microfluidics. Examples of applications and reaction schemes which rely on the discussed manipulation techniques are also presented, such as the fabrication of special materials and biophysical experiments.

Biotechnological production of enantiomerically pure d-lactic acid.

PubMed

Klotz, Silvia; Kaufmann, Norman; Kuenz, Anja; Prüße, Ulf

2016-11-01

The fermentation process of l-lactic acid is well known. Little importance was attached to d-lactic acid, but in the past 10 years, d-lactic acid gained significantly in importance. d-Lactic acid is an interesting precursor for manufacturing heat-resistant polylactic acid (PLA) bioplastics which can be widely used, for example as packaging material, coatings, for textiles or in the automotive industry.This review provides a comprehensive overview of the most recent developments, including a spectrum of studied microorganisms and their capabilities for the production of d-lactic acid. Additionally, the technological achievements in biotechnological d-lactic acid production including fermentation techniques like fed batch, simultaneous saccharification, and fermentation and continuous techniques are presented. Attention is also turned to suitable alternative substrates and their applicability in fermentation processes. Furthermore, advantages and disadvantages of product recovery and purification are discussed. Economic aspects of PLA are pointed out, and the present industrial producers of lactic acid are briefly introduced.

Ecology and distribution of Bulinus truncatus in the Middle East

PubMed Central

Watson, J. M.

1958-01-01

The author gives a comprehensive account of the present status of knowledge regarding the ecology and distribution of Bulinus truncatus, the intermediate host of Schistosoma haematobium in the Middle East and North Africa. He discusses in detail the types of habitat favoured by this snail, its life-cycle and seasonal variations in its populations, the effect of ecological factors on its distribution and occurrence, and the relationship between its control and its bionomics, stressing the many aspects of these subjects that require further investigation and suggesting lines for future research. In addition, the author outlines briefly the effect of some human activities (for example, extension of irrigation and agriculture), in their relationship to the snail host, on the incidence of bilharziasis haematobia in the Middle East and Africa. He concludes the paper with a summary of the three basic needs in respect of bilharziasis control: ecological research; prevention of pollution of waters with human excrement; and avoidance of human contact with infective water. PMID:13573115

Psychoanalysis and the Challenges of Disciplinary Exportation: Notes from the African "Periphery" on the Method/Theory Distinction.

PubMed

Barratt, Barnaby B

2018-02-01

This paper briefly reports on the current expansion of opportunities for clinical education in psychoanalysis in southern Africa, various regions of Asia, and Iran. It is a preliminary reconsideration of whether the disciplinary export of psychoanalysis is another egregious exercise in neo-colonialism, as contrasted with its possibly liberatory significance. The author argues that much of the discussion around the universality of many theoretical propositions needs to be reformulated. For example, the controversies over the Oedipus complex have typically been articulated in terms of the effects of specific social arrangements, familial structures, and styles of maternal and paternal functioning, rather than in terms of the universal-but with much cultural variation in its implementation-incest taboo. It is argued that dissemination of the psychoanalytic method (and the four coordinates that follow from it) may be desirable, but in ways the export of the hermeneutic assumptions of certain theoretical models is not.

Designing strategies and tools for teacher training: The role of critical details, examples in optics

NASA Astrophysics Data System (ADS)

Viennot, Laurence; Chauvet, Françoise; Colin, Philippe; Rebmann, Gérard

2005-01-01

Within the overall STTIS (Science Teacher Training in an Information Society) framework, this paper focuses on transformations of innovative teaching of optics, following a recommended change of approach to optics in the French curriculum. The empirical investigation of how teachers responded to this change, the main results of which are briefly presented here, identified a crucial aspect of the problem. This is the importance of critical detail'': that is, the fact that the linkage between certain critical details of practice and the fundamental rationale of a teaching sequence is often not easily understood by teachers, even those who are strongly motivated. The paper then discusses the development of guidelines for the design of training materials based on these research findings, which show how teachers typically tend to transform innovations when putting them into practice. We describe the rationale behind and structure of some teacher training materials intended to facilitate awareness and mastery in this respect.

Hints for new sources of flavour violation in meson mixing

NASA Astrophysics Data System (ADS)

Blanke, M.

2017-07-01

The recent results by the Fermilab-Lattice and MILC collaborations on the hadronic matrix elements entering B_{d,s} - bar{B}_{d,s} mixing show a significant tension of the measured values of the mass differences Δ M_{d,s} with their SM predictions. We review the implications of these results in the context of Constrained Minimal Flavour Violation models. In these models, the CKM elements γ and \\vert V_{ub}\\vert/\\vert V_{cb}\\vert can be determined from B_{d,s} - bar{B}_{d,s} mixing observables, yielding a prediction for γ below its tree-level value. Determining subsequently \\vert V_{cb}\\vert from the measured value of either Δ M_s or ɛ_K gives inconsistent results, with the tension being smallest in the Standard Model limit. This tension can be resolved if the flavour universality of new contributions to Δ F = 2 observables is broken. We briefly discuss the case of U(2)^3 flavour models as an illustrative example.

Hal: an automated pipeline for phylogenetic analyses of genomic data.

PubMed

Robbertse, Barbara; Yoder, Ryan J; Boyd, Alex; Reeves, John; Spatafora, Joseph W

2011-02-07

The rapid increase in genomic and genome-scale data is resulting in unprecedented levels of discrete sequence data available for phylogenetic analyses. Major analytical impasses exist, however, prior to analyzing these data with existing phylogenetic software. Obstacles include the management of large data sets without standardized naming conventions, identification and filtering of orthologous clusters of proteins or genes, and the assembly of alignments of orthologous sequence data into individual and concatenated super alignments. Here we report the production of an automated pipeline, Hal that produces multiple alignments and trees from genomic data. These alignments can be produced by a choice of four alignment programs and analyzed by a variety of phylogenetic programs. In short, the Hal pipeline connects the programs BLASTP, MCL, user specified alignment programs, GBlocks, ProtTest and user specified phylogenetic programs to produce species trees. The script is available at sourceforge (http://sourceforge.net/projects/bio-hal/). The results from an example analysis of Kingdom Fungi are briefly discussed.

Plea to African heads-of-state: join the fight.

PubMed

Tyson, R

1997-10-01

Uganda's president, Yoweri Museveni, is the only African head-of-state who has led an all-out, extended campaign against AIDS, and Uganda is the only African country to realize a decline in HIV rates since the epidemic began spreading across central and southern Africa in the 1980s. While South Africa's President Nelson Mandela has spoken about AIDS in international forums, his country's programs against AIDS are in disarray. Rather than adopt a position of leadership against HIV/AIDS, African leaders have most often tried to cover up or ignore the AIDS threat. Zimbabwe and Nigeria are briefly discussed as examples. More than 100 delegates attended the HIV/AIDS workshop at the fourth African-African American Summit held in Harare, July 1997. After listening for 2 days to medical experts describe how the epidemic is destroying African economies and social structures, task force members called upon leaders of the 40 sub-Saharan African countries to acknowledge the threat of AIDS in their countries and to fight against the epidemic.

The role of haptic versus visual volume cues in the size-weight illusion.

PubMed

Ellis, R R; Lederman, S J

1993-03-01

Three experiments establish the size-weight illusion as a primarily haptic phenomenon, despite its having been more traditionally considered an example of vision influencing haptic processing. Experiment 1 documents, across a broad range of stimulus weights and volumes, the existence of a purely haptic size-weight illusion, equal in strength to the traditional illusion. Experiment 2 demonstrates that haptic volume cues are both sufficient and necessary for a full-strength illusion. In contrast, visual volume cues are merely sufficient, and produce a relatively weaker effect. Experiment 3 establishes that congenitally blind subjects experience an effect as powerful as that of blindfolded sighted observers, thus demonstrating that visual imagery is also unnecessary for a robust size-weight illusion. The results are discussed in terms of their implications for both sensory and cognitive theories of the size-weight illusion. Applications of this work to a human factors design and to sensor-based systems for robotic manipulation are also briefly considered.