THERMODYNAMICS OF FE-CU ALLOYS AS DESCRIBED BY A CLASSIC POTENTIALS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caro, A; Caro, M; Lopasso, E M

2005-04-14

The Fe-Cu system is of relevance to the nuclear industry because of the deleterious consequences of Cu precipitates in the mechanical properties of Fe. Several sets of classical potentials are used in molecular dynamics simulations studies of this system, in particular that proposed by Ludwig et al. (Modelling Simul. Mater. Sci. Eng. 6, 19 (1998)). In this work we extract thermodynamic information from this interatomic potentials. We obtain equilibrium phase diagram and find a reasonable agreement with the experimental phases in the regions of relevance to radiation damage studies. We compare the results with the predicted phase diagram based onmore » other potential, as calculated in previous work. We discuss the disagreements found between the phase diagram calculated here and experimental results, focusing on the pure components and discuss the applicability of these potentials; finally we suggest an approach to improve existing potentials for this system.« less

Cambrian potential indicated in Kentucky Rome trough

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, D.C.; Drahovzal, J.A.

1996-02-19

This paper reviews recent gas discoveries in the Kentucky Rome trough and the implications for future developments. It reviews the geology and stratigraphy of this structure and identifies the potential zones of production and trapping mechanisms. It provides results from geologic logs and seismic data to provide cross sectional and structural interpretations. Finally it discusses the gas composition of natural gas recovered from the basin.

Environmental Impact Analysis Process. Volume 3. Preliminary Final Environmental Impact Statement Construction and Operation of Space Launch Complex 7

DTIC Science & Technology

1989-10-23

817) 824-5606. Reelfoot Lake Water Level believes that the proposed timber EIS No. 890197. Final, USA. UT, Tooele Management Plan. Implementation...2: Incidenial lake erit The potential need for an incidental take permit is discussed in Section 4.4.1, Regional Environment. Comment No. 3...and Crow Indian Tribes. Yellowstone, E02, Lake Catamount ResortAvailability Big Horn and Rosebud Counties, MT, Construction. Special Use Permit

Investigating change in a nursing context.

PubMed

Sheehan, J

1990-07-01

This paper focuses on 'why', 'what' and 'how' issues as they relate to the investigation of change in a nursing context. The why issues revolve around the need for change, and evolutionary and revolutionary change are discussed. Next the what issues are discussed and some variables involved in the change process are identified, and the role of change agents is outlined. Change strategies such as the power-coercive, the rational-empirical and the normative-re-education are discussed. Finally, the potential of action research in the context of bringing about change is advanced.

Carbon Nanotubes as Optical Sensors in Biomedicine.

PubMed

Farrera, Consol; Torres Andón, Fernando; Feliu, Neus

2017-11-28

Single-walled carbon nanotubes (SWCNTs) have become potential candidates for a wide range of medical applications including sensing, imaging, and drug delivery. Their photophysical properties (i.e., the capacity to emit in the near-infrared), excellent photostability, and fluorescence, which is highly sensitive to the local environment, make SWCNTs promising optical probes in biomedicine. In this Perspective, we discuss the existing strategies for and challenges of using carbon nanotubes for medical diagnosis based on intracellular sensing as well as discuss also their biocompatibility and degradability. Finally, we highlight the potential improvements of this nanotechnology and future directions in the field of carbon nanotubes for biomedical applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgess, Antony W., E-mail: burgess@ludwig.edu.au; Faux, Maree C.; Layton, Meredith J.

In this brief overview we discuss the association between Wnt signaling and colon cell biology and tumorigenesis. Our current understanding of the role of Apc in the {beta}-catenin destruction complex is compared with potential roles for Apc in cell adhesion and migration. The requirement for phosphorylation in the proteasomal-mediated degradation of {beta}-catenin is contrasted with roles for phospho-{beta}-catenin in the activation of transcription, cell adhesion and migration. The synergy between Myb and {beta}-catenin regulation of transcription in crypt stem cells during Wnt signaling is discussed. Finally, potential effects of growth factor regulatory systems, Apc or truncated-Apc on crypt morphogenesis, stemmore » cell localization and crypt fission are considered.« less

The Role of Biomarkers in Detection of Cardio-toxicity.

PubMed

Shah, Kevin S; Yang, Eric H; Maisel, Alan S; Fonarow, Gregg C

2017-06-01

The goal of this paper is to review the current literature on the role of biomarkers in the detection and management of patients with cardio-oncologic disease. The role of biomarker surveillance in patients with known cardiac disease, as a result of chemotherapy or with the potential to develop cardio-toxicity, will be discussed. In addition, the studies surrounding sub-clinical cardiac toxicity monitoring during therapy, identification of high-risk patients prior to therapy, and tailoring oncologic therapies to potential biomarker risk profiles are reviewed. Based on evidence, to date, troponin and natriuretic peptides have the greatest potential to detect sub-clinical cardiac dysfunction and even tailor therapy to prevent progression based on biomarker profiles. Finally, future directions for potential utilization of novel biomarkers for the improvement of care of patients in the field of cardio-oncology are discussed.

Geological investigation of the Socorro geothermal area. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapin, C.E.; Sanford, A.R.; White, D.W.

1979-05-01

The results of a comprehensive geological and geochemical study of the Socorro geothermal area are presented. The following are discussed: geologic setting, structural controls, stratigraphic controls, an ancient geothermal system, modern magma bodies, geothermal potential of the Socorro area, and the Socorro transverse shear zone. (MHR)

The potential application of the blackboard model of problem solving to multidisciplinary design

NASA Technical Reports Server (NTRS)

Rogers, James L.

1989-01-01

The potential application of the blackboard model of problem solving to multidisciplinary design is discussed. Multidisciplinary design problems are complex, poorly structured, and lack a predetermined decision path from the initial starting point to the final solution. The final solution is achieved using data from different engineering disciplines. Ideally, for the final solution to be the optimum solution, there must be a significant amount of communication among the different disciplines plus intradisciplinary and interdisciplinary optimization. In reality, this is not what happens in today's sequential approach to multidisciplinary design. Therefore it is highly unlikely that the final solution is the true optimum solution from an interdisciplinary optimization standpoint. A multilevel decomposition approach is suggested as a technique to overcome the problems associated with the sequential approach, but no tool currently exists with which to fully implement this technique. A system based on the blackboard model of problem solving appears to be an ideal tool for implementing this technique because it offers an incremental problem solving approach that requires no a priori determined reasoning path. Thus it has the potential of finding a more optimum solution for the multidisciplinary design problems found in today's aerospace industries.

CD ROM (Compact Disc Read Only Memory): Potential Uses at Air University.

DTIC Science & Technology

1988-04-01

5 Library Science .................................... 6 Medicine........................................... 7 Law...publishing, business, education, library science , medicine, law, weather, cartography, and navigation will be discussed. Finally, Chapter One will conclude...substantial impact in the following disciplines: publishing, business, education, library science , medicine, law, weather and cartography. This portion of 4

Darda's Demon and the First Law of Thermodynamics.

ERIC Educational Resources Information Center

Butcher, Frank

1984-01-01

Describes an experiment in which the final speed of a toy car is predicted by measuring the elastic potential energy stored in its spring at the start and the energy lost to friction during the run. Conservation of energy is discussed and the necessary mathematical formulas are presented. (BC)

Democracy and Civil Rights: The Universalizing Influence of Public Argumentation.

ERIC Educational Resources Information Center

Condit, Celeste Michelle

1987-01-01

Examines American public discourse about civil rights in national magazines from 1939-1959, indicating three stages in the controversy: (1) a positive recharacterization of blacks, (2) an inclusion of blacks under the nation's ideographs, and (3) a final contest between segregationist and integrationist rhetorics. Discusses the potential for…

Integrating Severely Handicapped Learners: Potential Teacher Liability in Community Based Programs.

ERIC Educational Resources Information Center

Brady, Michael P.; Dennis, H. Floyd

1984-01-01

The paper examines elements of negligence and other legal concerns in view of the evolving trend to educate severely handicapped persons in integrated, community based settings. Duty, care, risk, and appropriate placement and instruction are discussed. Finally, recommendations for avoiding teacher liability are presented. (Author/CL)

Novel nanodispersed coal liquefaction catalysts: Molecular design via microemulsion-based synthesis. Final technical report, October 1990--December 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osseo-Asare, K.; Boakye, E.; Vittal, M.

1995-04-01

This report described the synthesis of Molybdenum Sulfides in microemulsions by acidification of ammonium tetrathiomolybdate. Molybdenum Sulfides have been shown to be potential coal liquefaction catalysts. The importance of particle size, temperature effects, and coal surface chemistry to impregnation are discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Filinov, A.V.; Golubnychiy, V.O.; Bonitz, M.

Extending our previous work [A.V. Filinov et al., J. Phys. A 36, 5957 (2003)], we present a detailed discussion of accuracy and practical applications of finite-temperature pseudopotentials for two-component Coulomb systems. Different pseudopotentials are discussed: (i) the diagonal Kelbg potential, (ii) the off-diagonal Kelbg potential, (iii) the improved diagonal Kelbg potential, (iv) an effective potential obtained with the Feynman-Kleinert variational principle, and (v) the 'exact' quantum pair potential derived from the two-particle density matrix. For the improved diagonal Kelbg potential, a simple temperature-dependent fit is derived which accurately reproduces the 'exact' pair potential in the whole temperature range. The derivedmore » pseudopotentials are then used in path integral Monte Carlo and molecular-dynamics (MD) simulations to obtain thermodynamical properties of strongly coupled hydrogen. It is demonstrated that classical MD simulations with spin-dependent interaction potentials for the electrons allow for an accurate description of the internal energy of hydrogen in the difficult regime of partial ionization down to the temperatures of about 60 000 K. Finally, we point out an interesting relationship between the quantum potentials and the effective potentials used in density-functional theory.« less

The gut-kidney axis in chronic renal failure: A new potential target for therapy.

PubMed

Khoury, Tawfik; Tzukert, Keren; Abel, Roy; Abu Rmeileh, Ayman; Levi, Ronen; Ilan, Yaron

2017-07-01

Evidence is accumulating to consider the gut microbiome as a central player in the gut-kidney axis. Microbiome products, such as advanced glycation end products, phenols, and indoles, are absorbed into the circulation but are cleared by normal-functioning kidneys. These products then become toxic and contribute to the uremic load and to the progression of chronic kidney failure. In this review, we discuss the gut-kidney interaction under the state of chronic kidney failure as well as the potential mechanisms by which a change in the gut flora (termed gut dysbiosis) in chronic kidney disease (CKD) exacerbates uremia and leads to further progression of CKD and inflammation. Finally, the potential therapeutic interventions to target the gut microbiome in CKD are discussed. © 2016 International Society for Hemodialysis.

State-of-the-art molecular imaging in esophageal cancer management: implications for diagnosis, prognosis, and treatment

PubMed Central

Lin, Jolinta; Kligerman, Seth; Goel, Rakhi; Sajedi, Payam; Suntharalingam, Mohan

2015-01-01

Molecular imaging techniques are increasingly being used in addition to standard imaging methods such as endoscopic ultrasound (EUS) and computed tomography (CT) for many cancers including those of the esophagus. In this review, we will discuss the utility of the most widely used molecular imaging technique, 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). 18F-FDG PET has a variety of potential applications ranging from improving staging accuracy at the time of initial diagnosis to assisting in radiation target volume delineation. Furthermore, 18F-FDG PET can be used to evaluate treatment response after completion of neoadjuvant therapy or potentially during neoadjuvant therapy. Finally, we will also discuss other novel molecular imaging techniques that have potential to further improve cancer care. PMID:25642333

Molecular Imaging and Precision Medicine in Prostate Cancer.

PubMed

Ceci, Francesco; Fiorentino, Michelangelo; Castellucci, Paolo; Fanti, Stefano

2017-01-01

The aim of the present review is to discuss about the role of new probes for molecular imaging in the evaluation of prostate cancer (PCa). This review focuses particularly on the role of new promising radiotracers for the molecular imaging with PET/computed tomography in the detection of PCa recurrence. The role of these new imaging techniques to guide lesion-target therapies and the potential application of these molecular probes as theranostics agents is discussed. Finally, the molecular mechanisms underlying resistance to castration in PCa and the maintenance of active androgen receptor are discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

Why should the baby live? Human right to life and the precautionary principle.

PubMed

Rocchi, Benedetto

2013-05-01

This paper discusses the issue of 'post-birth abortion' from an applied perspective. Three hypothetical situations where a newborn considered as a 'potential person' is at risk of being killed are proposed to highlight the potential controversial outcomes of post-birth abortion. The internal consistency of the argument proposed by Giubilini and Minerva to morally justify newborn killing is contested as well. Finally, an alternative moral strategy based on the precautionary principle and excluding any distinction between potential and actual persons is proposed as rational.

Higgs Boson Searches at Hadron Colliders (1/4)

ScienceCinema

Jakobs, Karl

2018-05-21

In these Academic Training lectures, the phenomenology of Higgs bosons and search strategies at hadron colliders are discussed. After a brief introduction on Higgs bosons in the Standard Model and a discussion of present direct and indirect constraints on its mass the status of the theoretical cross section calculations for Higgs boson production at hadron colliders is reviewed. In the following lectures important experimental issues relevant for Higgs boson searches (trigger, measurements of leptons, jets and missing transverse energy) are presented. This is followed by a detailed discussion of the discovery potential for the Standard Model Higgs boson for both the Tevatron and the LHC experiments. In addition, various scenarios beyond the Standard Model, primarily the MSSM, are considered. Finally, the potential and strategies to measured Higgs boson parameters and the investigation of alternative symmetry breaking scenarios are addressed.

Synthesis of Helical Carbon Fibers and Related Materials: A Review on the Past and Recent Developments

PubMed Central

Raghubanshi, Himanshu; Dikio, Ezekiel Dixon

2015-01-01

Helical carbon fibers (HCFs) have been widely studied due to their unique helical morphology and superior properties, which make them efficient materials for several potential applications. This review summarizes the past and current advancement on the synthesis of HCFs. The review focuses and discusses synthesis strategies and effect of experimental parameters on the growth of HCFs. The effect of preparation method of catalyst, catalyst nature, catalyst composition, catalyst size, catalyst initial and final shape, reaction temperature, reaction time, carbon source, impurities, and electromagnetic field on the growth of HCFs is reviewed. We also discuss the growth mechanism for HCFs and the synthesis of HCFs related materials. Finally, we conclude with a brief summary and an outlook on the challenges and future prospects of HCFs. PMID:28347045

Advances in magnetic tweezers for single molecule and cell biophysics.

PubMed

Kilinc, Devrim; Lee, Gil U

2014-01-01

Magnetic tweezers (MTW) enable highly accurate forces to be transduced to molecules to study mechanotransduction at the molecular or cellular level. We review recent MTW studies in single molecule and cell biophysics that demonstrate the flexibility of this technique. We also discuss technical advances in the method on several fronts, i.e., from novel approaches for the measurement of torque to multiplexed biophysical assays. Finally, we describe multi-component nanorods with enhanced optical and magnetic properties and discuss their potential as future MTW probes.

Thermal management and mechanical structures for silicon detector systems

NASA Astrophysics Data System (ADS)

Viehhauser, G.

2015-09-01

Due to the size of current silicon tracking systems system aspects have become a major design driver. This article discusses requirements for the engineering of the mechanical structures and thermal management of such systems and reviews solutions developed to satisfy them. Modern materials and fabrication techniques have been instrumental in constructing these devices and will be discussed here. Finally, this paper will describe current and potential future developments in the engineering of silicon tracking systems which will shape the silicon tracking systems of the future.

Dynamical analysis of cigarette smoking model with a saturated incidence rate

NASA Astrophysics Data System (ADS)

Zeb, Anwar; Bano, Ayesha; Alzahrani, Ebraheem; Zaman, Gul

2018-04-01

In this paper, we consider a delayed smoking model in which the potential smokers are assumed to satisfy the logistic equation. We discuss the dynamical behavior of our proposed model in the form of Delayed Differential Equations (DDEs) and show conditions for asymptotic stability of the model in steady state. We also discuss the Hopf bifurcation analysis of considered model. Finally, we use the nonstandard finite difference (NSFD) scheme to show the results graphically with help of MATLAB.

Buprenorphine and Buprenorphine/Naloxone Diversion, Misuse, and Illicit Use: An International Review

PubMed Central

Yokell, Michael A.; Zaller, Nickolas D.; Green, Traci C.; Rich, Josiah D.

2011-01-01

The diversion, misuse, and non-medically supervised use of buprenorphine and buprenorphine/naloxone by opioid users are reviewed. Buprenorphine and buprenorphine/naloxone are used globally as opioid analgesics and in the treatment of opioid dependency. Diversion of buprenorphine and buprenorphine/naloxone represents a complex medical and social issue, and has been widely documented in various geographical regions throughout the world. We first discuss the clinical properties of buprenorphine and its abuse potential. Second, we discuss its diversion and illicit use on an international level, as well as motivations for those activities. Third, we examine the medical risks and benefits of buprenorphine’s non-medically supervised use and misuse. These risks and benefits include the effect of buprenorphine’s use on HIV risk and the risk of its concomitant use with other medications and drugs of abuse. Finally, we discuss the implications of diversion, misuse, and non-medically supervised use (including potential measures to address issues of diversion); and potential areas for further research. PMID:21466501

The Educationally Deprived: The Potential for Change.

ERIC Educational Resources Information Center

Clark, Kenneth B.; And Others

The Hazen Foundation authorized a study on the causes and implications of racial differences in academic motivation, with the longrun goal of improving higher educational opportunities for Negroes. The final phase of this study was a work conference by theorists and practitioners for discussion of the findings from two separate research methods.…

College and Industry: Partners in the Handicapped Role (Cipher III).

ERIC Educational Resources Information Center

Katz, David; And Others

A project was designed and instituted to furnish a structure that would bring together three groups--potential employers, college personnel, and disabled people--to increase employment opportunities for the handicapped. During the third and final project year, representatives of all three groups met in workshops to discuss issues and concerns.…

Updated assessment of the critical environmental factors involved in the prevention of allergic disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, A.R.

1979-06-01

The effects of climate, as well as outdoor and indoor pollution, on allergic respiratory symptoms are herein explored. Also, measures utilized in modifying the susceptible individual's milieu are examined. Finally, the potential for ameliorating or preventing the development of allergies in genetically predisposed children is discussed.

77 FR 38375 - Notice of Availability of the Final Environmental Impact Statement (FEIS) for the Taos Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... warranted. However, FAA's review of current information did note that some social and environmental changes... alternatives conducted in this FEIS. However, to document and disclose the social and environmental changes... discusses any potential impacts related to the changed social and environmental conditions. The technical...

Evolutionary potential games on lattices

NASA Astrophysics Data System (ADS)

Szabó, György; Borsos, István

2016-04-01

Game theory provides a general mathematical background to study the effect of pair interactions and evolutionary rules on the macroscopic behavior of multi-player games where players with a finite number of strategies may represent a wide scale of biological objects, human individuals, or even their associations. In these systems the interactions are characterized by matrices that can be decomposed into elementary matrices (games) and classified into four types. The concept of decomposition helps the identification of potential games and also the evaluation of the potential that plays a crucial role in the determination of the preferred Nash equilibrium, and defines the Boltzmann distribution towards which these systems evolve for suitable types of dynamical rules. This survey draws parallel between the potential games and the kinetic Ising type models which are investigated for a wide scale of connectivity structures. We discuss briefly the applicability of the tools and concepts of statistical physics and thermodynamics. Additionally the general features of ordering phenomena, phase transitions and slow relaxations are outlined and applied to evolutionary games. The discussion extends to games with three or more strategies. Finally we discuss what happens when the system is weakly driven out of the "equilibrium state" by adding non-potential components representing games of cyclic dominance.

Pilot In Command: A Feasibility Assessment of Autonomous Flight Management Operations

NASA Technical Reports Server (NTRS)

Wing, David J.; Ballin, Mark G.; Krishnamurthy, Karthik

2004-01-01

Several years of NASA research have produced the air traffic management operational concept of Autonomous Flight Management with high potential for operational feasibility, significant system and user benefits, and safety. Among the chief potential benefits are demand-adaptive or scalable capacity, user flexibility and autonomy that may finally enable truly successful business strategies, and compatibility with current-day operations such that the implementation rate can be driven from within the user community. A concept summary of Autonomous Flight Management is provided, including a description of how these operations would integrate in shared airspace with existing ground-controlled flight operations. The mechanisms enabling the primary benefits are discussed, and key findings of a feasibility assessment of airborne autonomous operations are summarized. Concept characteristics that impact safety are presented, and the potential for initially implementing Autonomous Flight Management is discussed.

Psychiatry and online social media: potential, pitfalls and ethical guidelines for psychiatrists and trainees.

PubMed

Frankish, Katherine; Ryan, Christopher; Harris, Anthony

2012-06-01

This paper proposes ethical guidelines for psychiatrists and psychiatry trainees when interacting with social media. A three-stage process was followed in the development of these guidelines. A literature review provided situations and possible broad rules as to how social media could be ethically engaged. A roundtable discussion by a panel of invited psychiatrists, psychiatry trainees, psychologists, e-health practitioners, lawyers and consumers was held to discuss the situations and to better formulate the ethical principles upon which psychiatrists could act. These vignettes and principles were then broadly discussed at a seminar held at the 2011 RANZCP Congress. Finally, this paper was circulated to the original invitees for final comment. A set of recommendations for working with social media were developed. The new social media provides important avenues for communication, education and treatment. These avenues pose ethical and practical dilemmas that can be resolved by the application of established ethical principles. Practical recommendations for navigating social media are proposed.

Electroactive Biofilms: Current Status and Future Research Needs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borole, Abhijeet P; Reguera, Gemma; Ringeisen, Bradley

2011-01-01

Electroactive biofilms generated by electrochemically active microorganisms have many potential applications in bioenergy and chemicals production. This review assesses the effects of microbiological and process parameters on enrichment of such biofilms as well as critically evaluates the current knowledge of the mechanisms of extracellular electron transfer in BES systems. First we discuss the role of biofilm forming microorganisms vs. planktonic microorganisms. Physical, chemical and electrochemical parameters which dictate the enrichment and subsequent performance of the biofilms are discussed. Potential dependent biological parameters including biofilm growth rate, specific electron transfer rate and others and their relationship to BES system performance ismore » assessed. A review of the mechanisms of electron transfer in BES systems is included followed by a discussion of biofilm and its exopolymeric components and their electrical conductivity. A discussion of the electroactive biofilms in biocathodes is also included. Finally, we identify the research needs for further development of the electroactive biofilms to enable commercial applications.« less

Telerehabilitation robotics: bright lights, big future?

PubMed

Carignan, Craig R; Krebs, Hermano I

2006-01-01

The potential for remote diagnosis and treatment over the Internet using robotics is now a reality. The state of the art is exemplified by several Internet applications, and we explore the current trends in developing new systems. We review the technical challenges that lie ahead, along with some potential solutions. Some promising results for a new bilateral system involving two InMotion2 robots are presented. Finally, we discuss the future direction and commercial outlook for rehabilitation robots over the next 15 years.

Anaerobic digestion of organic solid poultry slaughterhouse waste--a review.

PubMed

Salminen, E; Rintala, J

2002-05-01

This work reviews the potential of anaerobic digestion for material recovery and energy production from poultry slaughtering by-products and wastes. First, we describe and quantify organic solid by-products and wastes produced in poultry farming and poultry slaughterhouses and discuss their recovery and disposal options. Then we review certain fundamental aspects of anaerobic digestion considered important for the digestion of solid slaughterhouse wastes. Finally, we present an overview of the future potential and current experience of the anaerobic digestion treatment of these materials.

Field-aligned current sources in the high-latitude ionosphere

NASA Technical Reports Server (NTRS)

Barbosa, D. D.

1979-01-01

The paper determines the electric potential in a plane which is fed current from a pair of field-aligned current sheets. The ionospheric conductivity is modelled as a constant with an enhanced conductivity annular ring. It is shown that field-aligned current distributions are arbitrary functions of azimuth angle (MLT) and thus allow for asymmetric potential configurations over the pole cap. In addition, ionospheric surface currents are computed by means of stream functions. Finally, the discussion relates these methods to the electrical characteristics of the magnetosphere.

Concurrent System Engineering and Risk Reduction for Dual-Band (RF/optical) Spacecraft Communications

NASA Technical Reports Server (NTRS)

Fielhauer, Karl, B.; Boone, Bradley, G.; Raible, Daniel, E.

2012-01-01

This paper describes a system engineering approach to examining the potential for combining elements of a deep-space RF and optical communications payload, for the purpose of reducing the size, weight and power burden on the spacecraft and the mission. Figures of merit and analytical methodologies are discussed to conduct trade studies, and several potential technology integration strategies are presented. Finally, the NASA Integrated Radio and Optical Communications (iROC) project is described, which directly addresses the combined RF and optical approach.

Evaluation Of Ion Exchange For Fabrication Of Rare-Earth Doped Waveguides

NASA Astrophysics Data System (ADS)

Howell, Brian P.; Beerling, Timothy

1987-01-01

Rare earth ions are frequently incorporated into lasers by doping common glasses with the ions in the glass melt. This paper describes the potential of using diffusion of the rare earth ion from molten salt baths to incorporate it in the glass. The paper discusses the molten salts, the rare earths as a group, the diffusion phenomena, the glasses, and finally the interaction of all these to produce the process. General predictions of the waveguide profile and potential problems are presented.

Virtual reality, disability and rehabilitation.

PubMed

Wilson, P N; Foreman, N; Stanton, D

1997-06-01

Virtual reality, or virtual environment computer technology, generates simulated objects and events with which people can interact. Existing and potential applications for this technology in the field of disability and rehabilitation are discussed. The main benefits identified for disabled people are that they can engage in a range of activities in a simulator relatively free from the limitations imposed by their disability, and they can do so in safety. Evidence that the knowledge and skills acquired by disabled individuals in simulated environments can transfer to the real world is presented. In particular, spatial information and life skills learned in a virtual environment have been shown to transfer to the real world. Applications for visually impaired people are discussed, and the potential for medical interventions and the assessment and treatment of neurological damage are considered. Finally some current limitations of the technology, and ethical concerns in relation to disability, are discussed.

Preparation and Application of Electrodes in Capacitive Deionization (CDI): a State-of-Art Review.

PubMed

Jia, Baoping; Zhang, Wei

2016-12-01

As a promising desalination technology, capacitive deionization (CDI) have shown practicality and cost-effectiveness in brackish water treatment. Developing more efficient electrode materials is the key to improving salt removal performance. This work reviewed current progress on electrode fabrication in application of CDI. Fundamental principal (e.g. EDL theory and adsorption isotherms) and process factors (e.g. pore distribution, potential, salt type and concentration) of CDI performance were presented first. It was then followed by in-depth discussion and comparison on properties and fabrication technique of different electrodes, including carbon aerogel, activated carbon, carbon nanotubes, graphene and ordered mesoporous carbon. Finally, polyaniline as conductive polymer and its potential application as CDI electrode-enhancing materials were also discussed.

Global trends in emerging viral diseases of wildlife origin

USGS Publications Warehouse

Sleeman, Jonathan M.; Ip, Hon S.

2015-01-01

The following article provides examples of recently emerged viral diseases of wildlife origin. The examples have been selected to illustrate the drivers of emerging viral diseases, both novel pathogens and previously known diseases, the impacts of these diseases, as well as the role of wildlife both as “villains” or reservoirs as well as “victims” of these viral diseases. The article also discusses potential management strategies for emerging viral diseases in wildlife populations and future science directions in wildlife health to prevent, prepare, respond to, and recover from these disease events. Finally, the concept of One Health and its potential role in developing solutions to these issues of mutual concern is discussed.

Applications of Brain–Machine Interface Systems in Stroke Recovery and Rehabilitation

PubMed Central

Francisco, Gerard E.; Contreras-Vidal, Jose L.

2014-01-01

Stroke is a leading cause of disability, significantly impacting the quality of life (QOL) in survivors, and rehabilitation remains the mainstay of treatment in these patients. Recent engineering and technological advances such as brain-machine interfaces (BMI) and robotic rehabilitative devices are promising to enhance stroke neu-rorehabilitation, to accelerate functional recovery and improve QOL. This review discusses the recent applications of BMI and robotic-assisted rehabilitation in stroke patients. We present the framework for integrated BMI and robotic-assisted therapies, and discuss their potential therapeutic, assistive and diagnostic functions in stroke rehabilitation. Finally, we conclude with an outlook on the potential challenges and future directions of these neurotechnologies, and their impact on clinical rehabilitation. PMID:25110624

Preliminary low-level waste feed definition guidance - LLW pretreatment interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shade, J.W.; Connor, J.M.; Hendrickson, D.W.

1995-02-01

The document describes limits for key constituents in the LLW feed, and the bases for these limits. The potential variability in the stream is then estimated and compared to the limits. Approaches for accomodating uncertainty in feed inventory, processing strategies, and process design (melter and disposal system) are discussed. Finally, regulatory constraints are briefly addressed.

Decision making in a multidisciplinary cancer team: does team discussion result in better quality decisions?

PubMed

Kee, Frank; Owen, Tracy; Leathem, Ruth

2004-01-01

To establish whether treatment recommendations made by clinicians concur with the best outcomes predicted from their prognostic estimates and whether team discussion improves the quality or outcome of their decision making, the authors studied real-time decision making by a lung cancer team. Clinicians completed pre- and postdiscussion questionnaires for 50 newly diagnosed patients. For each patient/doctor pairing, a decision model determined the expected patient outcomes from the clinician's prognostic estimates. The difference between the expected utility of the recommended treatment and the maximum utility derived from the clinician's predictions of the outcomes (the net utility loss) following all potential treatment modalities was calculated as an indicator of quality of the decision. The proportion of treatment decisions changed by the multidisciplinary team discussion was also calculated. Insofar as the change in net utility loss brought about by multidisciplinary team discussion was not significantly different from zero, team discussion did not improve the quality of decision making overall. However, given the modest power of the study, these findings must be interpreted with caution. In only 23 of 87 instances (26%) in which an individual specialist's initial treatment preference differed from the final group judgment did the specialist finally concur with the group treatment choice after discussion. This study does not support the theory that team discussion improves decision making by closing a knowledge gap.

The effects of hormonal contraceptives on glycemic regulation

PubMed Central

Cortés, Manuel E.; Alfaro, Andrea A.

2014-01-01

A number of side effects have been linked to the use of hormonal contraceptives, among others, alterations in glucose levels. Hence, the objective of this mini-review is to show the main effects of hormonal contraceptive intake on glycemic regulation. First, the most relevant studies on this topic are described, then the mechanisms that might be accountable for this glycemic regulation impairment as exerted by hormonal contraceptives are discussed. Finally, we briefly discuss the ethical responsibility of health professionals to inform about the potential risks on glycemic homeostasis regarding hormonal contraceptive intake. PMID:25249703

The electromagnetic analogy of a ball on a rotating conical turntable

NASA Astrophysics Data System (ADS)

Zengel, Keith

2017-12-01

A ball on a flat rotating turntable executes circular orbits analogous to those of a charged particle in a uniform magnetic field. Stable circular orbits are also possible on rotating conical turntables and are analogous to those of a charged particle in an axial magnetic field superimposed on a radial electric field. The existence and stability of these orbits is derived and discussed. Further, parallels are drawn between the mechanical and electromagnetic cases, with particular attention to the magnetic vector potential. Finally, an experimental confirmation is reported and discussed.

Structural design approaches for creating fat droplet and starch granule mimetics.

PubMed

McClements, David Julian; Chung, Cheryl; Wu, Bi-Cheng

2017-02-22

This article focuses on hydrogel-based strategies for creating reduced calorie foods with desirable physicochemical, sensory, and nutritional properties. Initially, the role of fat droplets and starch granules in foods is discussed, and then different methods for fabricating hydrogel beads are reviewed, including phase separation, antisolvent precipitation, injection, and emulsion template methods. Finally, the potential application of hydrogel beads as fat droplet and starch granule replacements is discussed. There is still a need for large-scale, high-throughout, and economical methods of fabricating hydrogel beads suitable for utilization within the food industry.

Applications and requirements for real-time simulators in ground-test facilities

NASA Technical Reports Server (NTRS)

Arpasi, Dale J.; Blech, Richard A.

1986-01-01

This report relates simulator functions and capabilities to the operation of ground test facilities, in general. The potential benefits of having a simulator are described to aid in the selection of desired applications for a specific facility. Configuration options for integrating a simulator into the facility control system are discussed, and a logical approach to configuration selection based on desired applications is presented. The functional and data path requirements to support selected applications and configurations are defined. Finally, practical considerations for implementation (i.e., available hardware and costs) are discussed.

Tip-Based Nanofabrication for Scalable Manufacturing

DOE PAGES

Hu, Huan; Kim, Hoe; Somnath, Suhas

2017-03-16

Tip-based nanofabrication (TBN) is a family of emerging nanofabrication techniques that use a nanometer scale tip to fabricate nanostructures. Here in this review, we first introduce the history of the TBN and the technology development. We then briefly review various TBN techniques that use different physical or chemical mechanisms to fabricate features and discuss some of the state-of-the-art techniques. Subsequently, we focus on those TBN methods that have demonstrated potential to scale up the manufacturing throughput. Finally, we discuss several research directions that are essential for making TBN a scalable nano-manufacturing technology.

Tip-Based Nanofabrication for Scalable Manufacturing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Huan; Kim, Hoe; Somnath, Suhas

Tip-based nanofabrication (TBN) is a family of emerging nanofabrication techniques that use a nanometer scale tip to fabricate nanostructures. Here in this review, we first introduce the history of the TBN and the technology development. We then briefly review various TBN techniques that use different physical or chemical mechanisms to fabricate features and discuss some of the state-of-the-art techniques. Subsequently, we focus on those TBN methods that have demonstrated potential to scale up the manufacturing throughput. Finally, we discuss several research directions that are essential for making TBN a scalable nano-manufacturing technology.

Applications of KPFM-Based Approaches for Surface Potential and Electrochemical Measurements in Liquid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, Liam F.; Weber, Stefan A. L.; Rodriguez, Brian

Kelvin probe force microscopy (KPFM) has been widely used to map nanoscale surface potentials of materials in ambient and ultra-high vacuum environments. However, to study and ultimately understand charge-related processes, e.g., in biological systems or to further improve energy storage devices such as electrochemical batteries, nanoscale surface potential measurements in liquid environments are required. Here, we describe the various implementations of KPFM-based approaches for measuring surface potentials in liquid environments. We provide practical guidelines for surface potential measurements and describe what other information can be obtained. Finally, we discuss potential applications and limitations of existing approaches and present possible solutionsmore » for the successful implementation of liquid KPFM.« less

Metal–organic and covalent organic frameworks as single-site catalysts

PubMed Central

Rogge, S. M. J.; Bavykina, A.; Hajek, J.; Garcia, H.; Olivos-Suarez, A. I.; Sepúlveda-Escribano, A.; Vimont, A.; Clet, G.; Bazin, P.; Kapteijn, F.

2017-01-01

Heterogeneous single-site catalysts consist of isolated, well-defined, active sites that are spatially separated in a given solid and, ideally, structurally identical. In this review, the potential of metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) as platforms for the development of heterogeneous single-site catalysts is reviewed thoroughly. In the first part of this article, synthetic strategies and progress in the implementation of such sites in these two classes of materials are discussed. Because these solids are excellent playgrounds to allow a better understanding of catalytic functions, we highlight the most important recent advances in the modelling and spectroscopic characterization of single-site catalysts based on these materials. Finally, we discuss the potential of MOFs as materials in which several single-site catalytic functions can be combined within one framework along with their potential as powerful enzyme-mimicking materials. The review is wrapped up with our personal vision on future research directions. PMID:28338128

Ultrafast and nonlinear surface-enhanced Raman spectroscopy.

PubMed

Gruenke, Natalie L; Cardinal, M Fernanda; McAnally, Michael O; Frontiera, Renee R; Schatz, George C; Van Duyne, Richard P

2016-04-21

Ultrafast surface-enhanced Raman spectroscopy (SERS) has the potential to study molecular dynamics near plasmonic surfaces to better understand plasmon-mediated chemical reactions such as plasmonically-enhanced photocatalytic or photovoltaic processes. This review discusses the combination of ultrafast Raman spectroscopic techniques with plasmonic substrates for high temporal resolution, high sensitivity, and high spatial resolution vibrational spectroscopy. First, we introduce background information relevant to ultrafast SERS: the mechanisms of surface enhancement in Raman scattering, the characterization of plasmonic materials with ultrafast techniques, and early complementary techniques to study molecule-plasmon interactions. We then discuss recent advances in surface-enhanced Raman spectroscopies with ultrafast pulses with a focus on the study of molecule-plasmon coupling and molecular dynamics with high sensitivity. We also highlight the challenges faced by this field by the potential damage caused by concentrated, highly energetic pulsed fields in plasmonic hotspots, and finally the potential for future ultrafast SERS studies.

New generation adjuvants--from empiricism to rational design.

PubMed

O'Hagan, Derek T; Fox, Christopher B

2015-06-08

Adjuvants are an essential component of modern vaccine development. Despite many decades of development, only a few types of adjuvants are currently included in vaccines approved for human use. In order to better understand the reasons that development of some adjuvants succeeded while many others failed, we discuss some of the common attributes of successful first generation adjuvants. Next, we evaluate current trends in the development of second generation adjuvants, including the potential advantages of rationally designed synthetic immune potentiators appropriately formulated. Finally, we discuss desirable attributes of next generation adjuvants. Throughout, we emphasize that the importance of formulation and analytical characterization in all aspects of vaccine adjuvant development is often underappreciated. We highlight the formulation factors that must be evaluated in order to optimize interactions between vaccine antigens, immune potentiators, and particulate formulations, and the resulting effects on safety, biological activity, manufacturability, and stability. Copyright © 2015 Elsevier Ltd. All rights reserved.

Content and format of labeling for human prescription drug and biological products; requirements for pregnancy and lactation labeling. Final rule.

PubMed

2014-12-04

The Food and Drug Administration (FDA) is amending its regulations governing the content and format of the "Pregnancy," "Labor and delivery," and "Nursing mothers" subsections of the "Use in Specific Populations" section of the labeling for human prescription drug and biological products. The final rule requires the removal of the pregnancy categories A, B, C, D, and X from all human prescription drug and biological product labeling. For human prescription drug and biological products subject to the Agency's 2006 Physician Labeling Rule, the final rule requires that the labeling include a summary of the risks of using a drug during pregnancy and lactation, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy and lactation. The final rule eliminates the "Labor and delivery" subsection because information about labor and delivery is included in the "Pregnancy" subsection. The final rule requires that the labeling include relevant information about pregnancy testing, contraception, and infertility for health care providers prescribing for females and males of reproductive potential. The final rule creates a consistent format for providing information about the risks and benefits of prescription drug and/or biological product use during pregnancy and lactation and by females and males of reproductive potential. These revisions will facilitate prescriber counseling for these populations.

Rising with De Colores: Tapping into the Resources of la Comunidad to Assist Under-Performing Chicano-Latino Students

ERIC Educational Resources Information Center

Ordonez-Jasis, Rosario; Jasis, Pablo

2004-01-01

This article explores the dynamics and educational potential of De Colores Community Learning Center, an after-school program serving low-performing Chicano-Latino children. The article discusses the foundational characteristics of De Colores and its quest to become a model of empowerment, instead of a more traditional model of service. Finally,…

Feasibility study of Northeast Thailand Gas Pipeline Project. Final report. Part 2. Compressed natural gas. Export trade information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The volume is the second part of a three part study submitted to the Petroleum Authority of Thailand. Part II analyzes the potential use of compressed natural gas (CNG) as a transportation fuel for high mileage vehicles traveling the highway system of Thailand. The study provides an initial estimate of buses and trucks that are potential candidates for converting to natural gas vehicles (NGV). CNG technology is briefly reviewed. The types of refueling stations that may be sited along the highway are discussed. The estimated capital investments and typical layouts are presented. The report also discusses the issues involved inmore » implementing a CNG program in Thailand, such as safety, user acceptability and the government's role.« less

Space environmental effects on polymer composites: Research needs and opportunities

NASA Technical Reports Server (NTRS)

Jang, Bor Z.; Bianchi, J.; Liu, Y. M.; Chang, C. P.

1993-01-01

The long-term performance of polymer-based composites in the space environment is discussed. Both thermoset and thermoplastic matrix composites are included in this discussion. Previous efforts on the space environmental effects on composites are briefly reviewed. Focus of this review is placed on the effects of hygrothermal stresses, atomic oxygen, ultraviolet (UV), and space debris/micrometeoroid impacts along with the potential synergism. Potential approaches to estimating the residual strength of polymer composites after exposure to atomic oxygen erosion or space debris/micrometeoroid impact are evaluated. New ground-based data are then utilized to illustrate the effects of atomic oxygen and thermal cycling on the failure behavior of polymer composites. Finally, research needs, challenges, and opportunities in the field of space environmental effects on composite materials are highlighted.

Global food security under climate change

PubMed Central

Schmidhuber, Josef; Tubiello, Francesco N.

2007-01-01

This article reviews the potential impacts of climate change on food security. It is found that of the four main elements of food security, i.e., availability, stability, utilization, and access, only the first is routinely addressed in simulation studies. To this end, published results indicate that the impacts of climate change are significant, however, with a wide projected range (between 5 million and 170 million additional people at risk of hunger by 2080) strongly depending on assumed socio-economic development. The likely impacts of climate change on the other important dimensions of food security are discussed qualitatively, indicating the potential for further negative impacts beyond those currently assessed with models. Finally, strengths and weaknesses of current assessment studies are discussed, suggesting improvements and proposing avenues for new analyses. PMID:18077404

High Power Hall Thrusters

NASA Technical Reports Server (NTRS)

Jankovsky, Robert; Tverdokhlebov, Sergery; Manzella, David

1999-01-01

The development of Hall thrusters with powers ranging from tens of kilowatts to in excess of one hundred kilowatts is considered based on renewed interest in high power. high thrust electric propulsion applications. An approach to develop such thrusters based on previous experience is discussed. It is shown that the previous experimental data taken with thrusters of 10 kW input power and less can be used. Potential mass savings due to the design of high power Hall thrusters are discussed. Both xenon and alternate thruster propellant are considered, as are technological issues that will challenge the design of high power Hall thrusters. Finally, the implications of such a development effort with regard to ground testing and spacecraft intecrati'on issues are discussed.

Test problems for inviscid transonic flow

NASA Technical Reports Server (NTRS)

Carlson, L. A.

1979-01-01

Solving of test problems with the TRANDES program is discussed. This method utilizes the full, inviscid, perturbation potential flow equation in a Cartesian grid system that is stretched to infinity. This equation is represented by a nonconservative system of finite difference equations that includes at supersonic points a rotated difference scheme and is solved by column relaxation. The solution usually starts from a zero perturbation potential on a very coarse grid (typically 13 by 7) followed by several grid halvings until a final solution is obtained on a fine grid (97 by 49).

Techniques and Tools for Performance Tuning of Parallel and Distributed Scientific Applications

NASA Technical Reports Server (NTRS)

Sarukkai, Sekhar R.; VanderWijngaart, Rob F.; Castagnera, Karen (Technical Monitor)

1994-01-01

Performance degradation in scientific computing on parallel and distributed computer systems can be caused by numerous factors. In this half-day tutorial we explain what are the important methodological issues involved in obtaining codes that have good performance potential. Then we discuss what are the possible obstacles in realizing that potential on contemporary hardware platforms, and give an overview of the software tools currently available for identifying the performance bottlenecks. Finally, some realistic examples are used to illustrate the actual use and utility of such tools.

Nonadiabatic Dynamics in Single-Electron Tunneling Devices with Time-Dependent Density-Functional Theory

NASA Astrophysics Data System (ADS)

Dittmann, Niklas; Splettstoesser, Janine; Helbig, Nicole

2018-04-01

We simulate the dynamics of a single-electron source, modeled as a quantum dot with on-site Coulomb interaction and tunnel coupling to an adjacent lead in time-dependent density-functional theory. Based on this system, we develop a time-nonlocal exchange-correlation potential by exploiting analogies with quantum-transport theory. The time nonlocality manifests itself in a dynamical potential step. We explicitly link the time evolution of the dynamical step to physical relaxation timescales of the electron dynamics. Finally, we discuss prospects for simulations of larger mesoscopic systems.

Energy conservation policy evaluation. Study module IA. Volume II. Technical appendix. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergstresser, K.; Berney, R.E.; Carter, L.F.

1978-01-01

This volume contains detailed technical analyses of the 19 energy conservation measures which were discussed as regional policy options in the report proper (PB-274 337). For each measure there is a description of how the measure works to reduce consumption; an assessment of potential savings, costs, and returns to adopters; probable 'normal' adoption rates under present policies; and potential adoption rates if some additional conservation policy options are implemented. Report includes chapters on environmental residuals from energy end uses, and policy preferences of households and energy marketers.

Nonadiabatic Dynamics in Single-Electron Tunneling Devices with Time-Dependent Density-Functional Theory.

PubMed

Dittmann, Niklas; Splettstoesser, Janine; Helbig, Nicole

2018-04-13

We simulate the dynamics of a single-electron source, modeled as a quantum dot with on-site Coulomb interaction and tunnel coupling to an adjacent lead in time-dependent density-functional theory. Based on this system, we develop a time-nonlocal exchange-correlation potential by exploiting analogies with quantum-transport theory. The time nonlocality manifests itself in a dynamical potential step. We explicitly link the time evolution of the dynamical step to physical relaxation timescales of the electron dynamics. Finally, we discuss prospects for simulations of larger mesoscopic systems.

Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 2

NASA Technical Reports Server (NTRS)

1984-01-01

The design, development and analysis of the 7.3MW MOD-5A wind turbine generator is documented. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 3, book 2 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. The subsystem for power generation, control, and instrumentation subsystems is described in detail. The manufacturing and construction plans, and the preparation of a potential site on Oahu, Hawaii, are documented. The quality assurance and safety plan, and analyses of failure modes and effects, and reliability, availability and maintainability are presented.

Generation of crystal structures using known crystal structures as analogues

PubMed Central

Cole, Jason C.; Groom, Colin R.; Read, Murray G.; Giangreco, Ilenia; McCabe, Patrick; Reilly, Anthony M.; Shields, Gregory P.

2016-01-01

This analysis attempts to answer the question of whether similar molecules crystallize in a similar manner. An analysis of structures in the Cambridge Structural Database shows that the answer is yes – sometimes they do, particularly for single-component structures. However, one does need to define what we mean by similar in both cases. Building on this observation we then demonstrate how this correlation between shape similarity and packing similarity can be used to generate potential lattices for molecules with no known crystal structure. Simple intermolecular interaction potentials can be used to minimize these potential lattices. Finally we discuss the many limitations of this approach. PMID:27484374

Quantitative characterization of surface topography using spectral analysis

NASA Astrophysics Data System (ADS)

Jacobs, Tevis D. B.; Junge, Till; Pastewka, Lars

2017-03-01

Roughness determines many functional properties of surfaces, such as adhesion, friction, and (thermal and electrical) contact conductance. Recent analytical models and simulations enable quantitative prediction of these properties from knowledge of the power spectral density (PSD) of the surface topography. The utility of the PSD is that it contains statistical information that is unbiased by the particular scan size and pixel resolution chosen by the researcher. In this article, we first review the mathematical definition of the PSD, including the one- and two-dimensional cases, and common variations of each. We then discuss strategies for reconstructing an accurate PSD of a surface using topography measurements at different size scales. Finally, we discuss detecting and mitigating artifacts at the smallest scales, and computing upper/lower bounds on functional properties obtained from models. We accompany our discussion with virtual measurements on computer-generated surfaces. This discussion summarizes how to analyze topography measurements to reconstruct a reliable PSD. Analytical models demonstrate the potential for tuning functional properties by rationally tailoring surface topography—however, this potential can only be achieved through the accurate, quantitative reconstruction of the PSDs of real-world surfaces.

Piezoelectric Micromachined Ultrasound Transducer (PMUT) Arrays for Integrated Sensing, Actuation and Imaging

PubMed Central

Qiu, Yongqiang; Gigliotti, James V.; Wallace, Margeaux; Griggio, Flavio; Demore, Christine E. M.; Cochran, Sandy; Trolier-McKinstry, Susan

2015-01-01

Many applications of ultrasound for sensing, actuation and imaging require miniaturized and low power transducers and transducer arrays integrated with electronic systems. Piezoelectric micromachined ultrasound transducers (PMUTs), diaphragm-like thin film flexural transducers typically formed on silicon substrates, are a potential solution for integrated transducer arrays. This paper presents an overview of the current development status of PMUTs and a discussion of their suitability for miniaturized and integrated devices. The thin film piezoelectric materials required to functionalize these devices are discussed, followed by the microfabrication techniques used to create PMUT elements and the constraints the fabrication imposes on device design. Approaches for electrical interconnection and integration with on-chip electronics are discussed. Electrical and acoustic measurements from fabricated PMUT arrays with up to 320 diaphragm elements are presented. The PMUTs are shown to be broadband devices with an operating frequency which is tunable by tailoring the lateral dimensions of the flexural membrane or the thicknesses of the constituent layers. Finally, the outlook for future development of PMUT technology and the potential applications made feasible by integrated PMUT devices are discussed. PMID:25855038

Reading Balint group work through Lacan's theory of the four discourses.

PubMed

Van Roy, Kaatje; Marché-Paillé, Anne; Geerardyn, Filip; Vanheule, Stijn

2016-02-05

In Balint groups, (para)medical professionals explore difficult interactions with patients by means of case presentations and discussions. As the process of Balint group work is not well understood, this article investigates Balint group meetings by making use of Lacan's theory of the four discourses. Five Balint group case presentations and their subsequent group discussion were studied, resulting in the observation of five crucial aspects of Balint group work. First, Balint group participants brought puzzlement to the group, which is indicative of the structural impossibility Lacan situates at the basis of all discourse (1). As for the group discussion, we emphasize 'hysterization' as a crucial process in Balint group work (2), the supporting role of the discourse of the analyst (3) and the centrality of discourse interactions (4). Finally, the potential transformation of the initial puzzlement is discussed (5). We conclude by putting forth the uniqueness of Balint group work as well as the potential usefulness of our analysis as a framework for Balint group leaders and professionals in charge of continuing medical education. © The Author(s) 2016.

Piezoelectric micromachined ultrasound transducer (PMUT) arrays for integrated sensing, actuation and imaging.

PubMed

Qiu, Yongqiang; Gigliotti, James V; Wallace, Margeaux; Griggio, Flavio; Demore, Christine E M; Cochran, Sandy; Trolier-McKinstry, Susan

2015-04-03

Many applications of ultrasound for sensing, actuation and imaging require miniaturized and low power transducers and transducer arrays integrated with electronic systems. Piezoelectric micromachined ultrasound transducers (PMUTs), diaphragm-like thin film flexural transducers typically formed on silicon substrates, are a potential solution for integrated transducer arrays. This paper presents an overview of the current development status of PMUTs and a discussion of their suitability for miniaturized and integrated devices. The thin film piezoelectric materials required to functionalize these devices are discussed, followed by the microfabrication techniques used to create PMUT elements and the constraints the fabrication imposes on device design. Approaches for electrical interconnection and integration with on-chip electronics are discussed. Electrical and acoustic measurements from fabricated PMUT arrays with up to 320 diaphragm elements are presented. The PMUTs are shown to be broadband devices with an operating frequency which is tunable by tailoring the lateral dimensions of the flexural membrane or the thicknesses of the constituent layers. Finally, the outlook for future development of PMUT technology and the potential applications made feasible by integrated PMUT devices are discussed.

Atmospheric Reanalyses-Recent Progress and Prospects for the Future. A Report from a Technical Workshop, April 2010. Volume 29

NASA Technical Reports Server (NTRS)

Rienecker, Michele M.; Dee, Dick; Woollen, Jack; Compo, Gilbert P.; Onogi, Kazutoshi; Gelaro, Ron; Bosilovich, Michael G.; daSilva, Arlindo; Pawson, Steven; Schubert, Siegfried;

Fitting in to Move Forward: How Belonging Affects Women in Physics

NASA Astrophysics Data System (ADS)

Ito, Tiffany

2017-01-01

This talk will consider different factors that have been shown to negatively affect women in physics and other STEM fields by decreasing their subjective sense of belonging, fit, and acceptance. I will discuss recent studies documenting gender disparities in belonging and the negative effect this has on women's persistence. I will also consider the effects of gender composition within group problem-solving tasks on women's belonging, behavior, and perceived competency. Finally, I will discuss potential interventions and changes in classroom context that may serve to encourage women and members of other underrepresented groups.

The Search for Neutrinos from Gamma Ray Bursts with AMANDA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuehn, Kyler

2006-05-19

We report on the combined analysis of over 400 GRB time periods that occurred during seven years of AMANDA observations. AMANDA has seen no neutrinos correlated with these bursts, thus we report a neutrino flux limit that is the most stringent observational limit to date. In light of the new observational opportunities afforded by Swift, we also discuss the future potential for GRB neutrino detection with AMANDA'S successor, IceCube. Finally, we briefly discuss the expansion of AMANDA'S transient point-source search to other phenomena, such as jet-driven supernovae and gamma-ray dark bursts.

Wildfire ignition resistant home design(WIRHD) program: Full-scale testing and demonstration final report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quarles, Stephen, L.; Sindelar, Melissa

2011-12-13

The primary goal of the Wildfire ignition resistant home design(WIRHD) program was to develop a home evaluation tool that could assess the ignition potential of a structure subjected to wildfire exposures. This report describes the tests that were conducted, summarizes the results, and discusses the implications of these results with regard to the vulnerabilities to homes and buildings.

Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions.

PubMed

Goulet, J P; Pérusse, R; Turcotte, J Y

1992-11-01

This article discusses the relative contraindications to the use of vasoconstrictor in patients currently medicated with tricyclic antidepressants, monoamine oxidase inhibitors, phenothiazines and beta-blockers. It reviews drug interactions and emphasizes potential detrimental systemic effects that epinephrine contained in local anesthetics can have when administered concomitantly with these drugs. Finally, special considerations are expressed concerning patients who abuse illicit drugs such as cocaine.

NASA aviation safety reporting system

NASA Technical Reports Server (NTRS)

1978-01-01

A sample of reports relating to operations during winter weather is presented. Several reports involving problems of judgment and decisionmaking have been selected from the numerous reports representative of this area. Problems related to aeronautical charts are discussed in a number of reports. An analytic study of reports involving potential conflicts in the immediate vicinity of uncontrolled airports was performed; the results are discussed in this report. It was found that in three-fourths of 127 such conflicts, neither pilot, or only one of the pilots, was communicating position and intentions on the appropriate frequency. The importance of providing aural transfer of information, as a backup to the visual see and avoid mode of information transfer is discussed. It was also found that a large fraction of pilots involved in potential conflicts on final approach had executed straight-in approaches, rather than the recommended traffic pattern entries, prior to the conflicts. A selection of alert bulletins and responses to them by various segments of the aviation community is presented.

Persufflation (or gaseous oxygen perfusion) as a method of organ preservation.

PubMed

Suszynski, Thomas M; Rizzari, Michael D; Scott, William E; Tempelman, Linda A; Taylor, Michael J; Papas, Klearchos K

2012-06-01

Improved preservation techniques have the potential to improve transplant outcomes by better maintaining donor organ quality and by making more organs available for allotransplantation. Persufflation, (PSF, gaseous oxygen perfusion) is potentially one such technique that has been studied for over a century in a variety of tissues, but has yet to gain wide acceptance for a number of reasons. A principal barrier is the perception that ex vivo PSF will cause in vivo embolization post-transplant. This review summarizes the extensive published work on heart, liver, kidney, small intestine and pancreas PSF, discusses the differences between anterograde and retrograde PSF, and between PSF and other conventional methods of organ preservation (static cold storage, hypothermic machine perfusion). Prospective implications of PSF within the broader field of organ transplantation, and in the specific application with pancreatic islet isolation and transplant are also discussed. Finally, key issues that need to be addressed before PSF becomes a more widely utilized preservation strategy are summarized and discussed. Copyright © 2012 Elsevier Inc. All rights reserved.

Persufflation (or Gaseous Oxygen Perfusion) as a Method of Organ Preservation

PubMed Central

Suszynski, Thomas M.; Rizzari, Michael D.; Scott, William E.; Tempelman, Linda A.; Taylor, Michael J.; Papas, Klearchos K.

2012-01-01

Improved preservation techniques have the potential to improve transplant outcomes by better maintaining donor organ quality and by making more organs available for allotransplantation. Persufflation, (PSF, gaseous oxygen perfusion) is potentially one such technique that has been studied for over a century in a variety of tissues, but has yet to gain wide acceptance for a number of reasons. A principal barrier is the perception that ex vivo PSF will cause in vivo embolization post-transplant. This review summarizes the extensive published work on heart, liver, kidney, small intestine and pancreas PSF, discusses the differences between anterograde and retrograde PSF and between PSF and other conventional methods of organ preservation (static cold storage, hypothermic machine perfusion). Prospective implications of PSF within the broader field of organ transplantation, and in the specific application with pancreatic islet isolation and transplant are also discussed. Finally, key issues that need to be addressed before PSF becomes a more widely utilized preservation strategy are summarized and discussed. PMID:22301419

New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges.

PubMed

Corrêa, Rúbia C G; Peralta, Rosane M; Haminiuk, Charles W I; Maciel, Giselle Maria; Bracht, Adelar; Ferreira, Isabel C F R

2018-04-13

Aging is an inevitable process influenced by genetic, lifestyle, and environmental factors. Indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. This report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. In addition to the extensively studied resveratrol, epicatechin, quercetin, and curcumin, new phytochemicals have been reported to act as anti-aging agents, such as the amino acid L-theanine isolated from green tea, and the lignans arctigenin and matairesinol isolated from Arctium lappa seeds. Furthermore, this review discusses the application of several new extracts rich in phytochemicals with potential use in anti-aging therapies. Finally, this review also discusses the most important biomarkers to test anti-aging interventions, the necessity of conducting epidemiological studies and the need of clinical trials with adequate study protocols for humans.

Race, ethnicity, and shared decision making for hyperlipidemia and hypertension treatment: the DECISIONS survey.

PubMed

Ratanawongsa, Neda; Zikmund-Fisher, Brian J; Couper, Mick P; Van Hoewyk, John; Powe, Neil R

2010-01-01

Racial/ethnic differences in shared decision making about cardiovascular risk-reduction therapy could affect health disparities. To investigate whether patient race/ethnicity is associated with experiences discussing cardiovascular risk-reduction therapy with health care providers. National sample of US adults identified by random-digit dialing. Cross-sectional survey conducted in November 2006 to May 2007. Among participants in the National Survey of Medical Decisions (DECISIONS), a nationally representative sample of English-speaking US adults aged 40 and older, the authors analyzed respondents who reported discussing hyperlipidemia or hypertension medications with a health care provider in the previous 2 years. In multivariate linear and logistic regressions adjusting for age, gender, income, insurance status, perceived health, and current therapy, they assessed the relation between race/ethnicity (black/Hispanic v. white) and decision making: knowledge, discussion of pros and cons of therapy, discussion of patient preference, who made the final decision, preferred involvement, and confidence in the decision. Of respondents who discussed high cholesterol (N = 738) or hypertension (N = 745) medications, 88% were white, 9% black, and 4% Hispanic. Minorities had lower knowledge scores than whites for hyperlipidemia (42% v. 52%, difference -10% [95% confidence interval (CI): 15, -5], P < 0.001), but not for hypertension. For hyperlipidemia, minorities were more likely than whites to report that the health care provider made the final decision for treatment (31.7% v. 12.3% whites, difference 19.4% [95% CI: 6.9, 33.1%], P < 0.01); this was not true for hypertension. Possible limitations include the small percentage of minorities in the sample and potential recall bias. Minorities considering hyperlipidemia therapy may be less informed about and less involved in the final decision-making process.

The Challenges of Projecting the Public Health Impacts of Marijuana Legalization in Canada Comment on "Legalizing and Regulating Marijuana in Canada: Review of Potential Economic, Social, and Health Impacts".

PubMed

Lake, Stephanie; Kerr, Thomas

2016-09-10

A recent editorial in this journal provides a summary of key economic, social, and public health considerations of the forthcoming legislation to legalize, regulate, and restrict access to marijuana in Canada. As our government plans to implement an evidence-based public health framework for marijuana legalization, we reflect and expand on recent discussions of the public health implications of marijuana legalization, and offer additional points of consideration. We select two commonly cited public concerns of marijuana legalization - adolescent usage and impaired driving - and discuss how the underdeveloped and equivocal body of scientific literature surrounding these issues limits the ability to predict the effects of legalization. Finally, we discuss the potential for some potential public health benefits of marijuana legalization - specifically the potential for marijuana to be used as a substitute to opioids and other risky substance use - that have to date not received adequate attention. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Building more powerful less expensive supercomputers using Processing-In-Memory (PIM) LDRD final report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, Richard C.

2009-09-01

This report details the accomplishments of the 'Building More Powerful Less Expensive Supercomputers Using Processing-In-Memory (PIM)' LDRD ('PIM LDRD', number 105809) for FY07-FY09. Latency dominates all levels of supercomputer design. Within a node, increasing memory latency, relative to processor cycle time, limits CPU performance. Between nodes, the same increase in relative latency impacts scalability. Processing-In-Memory (PIM) is an architecture that directly addresses this problem using enhanced chip fabrication technology and machine organization. PIMs combine high-speed logic and dense, low-latency, high-bandwidth DRAM, and lightweight threads that tolerate latency by performing useful work during memory transactions. This work examines the potential ofmore » PIM-based architectures to support mission critical Sandia applications and an emerging class of more data intensive informatics applications. This work has resulted in a stronger architecture/implementation collaboration between 1400 and 1700. Additionally, key technology components have impacted vendor roadmaps, and we are in the process of pursuing these new collaborations. This work has the potential to impact future supercomputer design and construction, reducing power and increasing performance. This final report is organized as follow: this summary chapter discusses the impact of the project (Section 1), provides an enumeration of publications and other public discussion of the work (Section 1), and concludes with a discussion of future work and impact from the project (Section 1). The appendix contains reprints of the refereed publications resulting from this work.« less

Fundamental transport mechanisms, fabrication and potential applications of nanoporous atomically thin membranes.

PubMed

Wang, Luda; Boutilier, Michael S H; Kidambi, Piran R; Jang, Doojoon; Hadjiconstantinou, Nicolas G; Karnik, Rohit

2017-06-06

Graphene and other two-dimensional materials offer a new approach to controlling mass transport at the nanoscale. These materials can sustain nanoscale pores in their rigid lattices and due to their minimum possible material thickness, high mechanical strength and chemical robustness, they could be used to address persistent challenges in membrane separations. Here we discuss theoretical and experimental developments in the emerging field of nanoporous atomically thin membranes, focusing on the fundamental mechanisms of gas- and liquid-phase transport, membrane fabrication techniques and advances towards practical application. We highlight potential functional characteristics of the membranes and discuss applications where they are expected to offer advantages. Finally, we outline the major scientific questions and technological challenges that need to be addressed to bridge the gap from theoretical simulations and proof-of-concept experiments to real-world applications.

Preferences and concerns of potential users in the selection of solar thermal systems for industrial and small utility applications

NASA Astrophysics Data System (ADS)

Gresham, J. B.; Kriz, T. A.

1981-03-01

To achieve widespread application in the industrial and utility sectors, solar systems must be economically competitive. Economic viability is, in turn, determined by a number of supporting criteria, ranging from system reliability to dispatch characteristics to how the system supports the main product line. In addition, solar systems possess some inherent attributes that may render some of the traditional supporting criteria inappropriate or require their redefinition. Those criteria and their relation to the solar investments are discussed in three steps. First, the main concerns and preferences of the potential users, as identified in recent SERI studies, are identified. Second, the equitability of the resulting decision criteria for solar investments are examined. Finally, the implications of these criteria for solar energy's penetration into these markets are discussed.

Showcasing electrode-electrolyte interfacial potential as a vital parameter in the hydrogen generation by metal oxides electrodes

NASA Astrophysics Data System (ADS)

Niveditha, C. V.; Nizamudeen, A. C.; Ramanarayanan, Rajita; Jabeen Fatima, M. J.; Swaminathan, Sindhu

2018-03-01

This investigation presents a new insight by experimentally demonstrating electrode-electrolyte interface potential that is flat band potential as a determinant in photoelectrochemical splitting of water. Two different metal oxides namely n type, nitrogen doped titania and p type copper oxides have been synthesized for the study. The flat band potential values of these oxide systems were obtained from Mott-Schottky analysis. The obtained flat band potential is used as a marker to fix the working potential in water splitting experiment. To obtain optimum photocurrent a potential more positive than flatband is applied to n-type N-TiO2 and vice-versa for p-type Cu2O. The findings are well supported by I-t curves derived from chronoamperometric measurements. Finally the mechanisms behind interfacial potential dynamics have been discussed in this work.

Ionization potential depression in an atomic-solid-plasma picture

NASA Astrophysics Data System (ADS)

Rosmej, F. B.

2018-05-01

Exotic solid density matter such as heated hollow crystals allow extended material studies while their physical properties and models such as the famous ionization potential depression are presently under renewed controversial discussion. Here we develop an atomic-solid-plasma (ASP) model that permits ionization potential depression studies also for single and multiple core hole states. Numerical calculations show very good agreement with recently available data not only in absolute values but also for Z-scaled properties while currently employed methods fail. For much above solid density compression, the ASP model predicts increased K-edge energies that are related to a Fermi surface rising. This is in good agreement with recent quantum molecular dynamics simulations. For hot dense matter a quantum number dependent optical electron finite temperature ion sphere model is developed that fits well with line shift and line disappearance data from dense laser produced plasma experiments. Finally, the physical transparency of the ASP picture allows a critical discussion of current methods.

A review of studies on ion thruster beam and charge-exchange plasmas

NASA Technical Reports Server (NTRS)

Carruth, M. R., Jr.

1982-01-01

Various experimental and analytical studies of the primary beam and charge-exchange plasmas of ion thrusters are reviewed. The history of plasma beam research is recounted, emphasizing experiments on beam neutralization, expansion of the beam, and determination of beam parameters such as electron temperature, plasma density, and plasma potential. The development of modern electron bombardment ion thrusters is treated, detailing experimental results. Studies on charge-exchange plasma are discussed, showing results such as the relationship between neutralizer emission current and plasma beam potential, ion energies as a function of neutralizer bias, charge-exchange ion current collected by an axially moving Faraday cup-RPA for 8-cm and 30-cm ion thrusters, beam density and potential data from a 15-cm ion thruster, and charge-exchange ion flow around a 30-cm thruster. A 20-cm thruster electrical configuration is depicted and facility effects are discussed. Finally, plasma modeling is covered in detail for plasma beam and charge-exchange plasma.

Comparative analysis of ArnCl2 (2 ? n ? 30) clusters taking into account molecular relaxation effects

NASA Astrophysics Data System (ADS)

Ferreira, G. G.; Borges, E.; Braga, J. P.; Belchior, J. C.

Cluster structures are discussed in a nonrigid analysis, using a modified minima search method based on stochastic processes and classical dynamics simulations. The relaxation process is taken into account considering the internal motion of the Cl2 molecule. Cluster structures are compared with previous works in which the Cl2 molecule is assumed to be rigid. The interactions are modeled using pair potentials: the Aziz and Lennard-Jones potentials for the Ar==Ar interaction, a Morse potential for the Cl==Cl interaction, and a fully spherical/anisotropic Morse-Spline-van der Waals (MSV) potential for the Ar==Cl interaction. As expected, all calculated energies are lower than those obtained in a rigid approximation; one reason may be attributed to the nonrigid contributions of the internal motion of the Cl2 molecule. Finally, the growing processes in molecular clusters are discussed, and it is pointed out that the growing mechanism can be affected due to the nonrigid initial conditions of smaller clusters such as ArnCl2 (n ? 4 or 5), which are seeds for higher-order clusters.

In the Blink of an Eye: Investigating the Role of Awareness in Fear Responding by Measuring the Latency of Startle Potentiation

PubMed Central

Åsli, Ole; Flaten, Magne A.

2012-01-01

The latency of startle reflex potentiation may shed light on the aware and unaware processes underlying associative learning, especially associative fear learning. We review research suggesting that single-cue delay classical conditioning is independent of awareness of the contingency between the conditioned stimulus (CS) and the unconditioned stimulus (US). Moreover, we discuss research that argues that conditioning independent of awareness has not been proven. Subsequently, three studies from our lab are presented that have investigated the role of awareness in classical conditioning, by measuring the minimum latency from CS onset to observed changes in reflexive behavior. In sum, research using this method shows that startle is potentiated 30 to 100 ms after CS onset following delay conditioning. Following trace fear conditioning, startle is potentiated 1500 ms after CS presentation. These results indicate that the process underlying delay conditioned responding is independent of awareness, and that trace fear conditioned responding is dependent on awareness. Finally, this method of investigating the role of awareness is discussed and future research possibilities are proposed. PMID:24962686

Propagation Path Effects for Rayleigh and Love Waves

DTIC Science & Technology

1981-05-01

The method finally selected is similar in some respects to the integral equation formulation. It is the Parker- Oldenburg -iuestis method (Parker, 1972...REGIONAL ANOMALIE S BASIN MODEL DEPTH RESIDUALS AND STRIPPING BOREHOLE DATA PROCESS DATA mots" 12 THE PARKER- OLDENBURG -HUESTIS POTENTIAL INVERSION Parker...series convergLnce and other properties are given by Parker (1972), Parker and Huestis (1974), and Oldenburg (1974). A discussion of this theory from

Visual Image Transmission. An Examination of Electronic Delivery of Visual Images and Text from the Library to the Academic Community. Final Report.

ERIC Educational Resources Information Center

Smith, Merrill W.; And Others

Designed to examine the potential for delivering images stored on videodisc and other optical media from the library to the classroom, the pilot project described in this report has focused on ways to transmit still color or black and white images from the library's collection to a constituent academic unit. This report discusses analog and…

Study 2.5 final report. DORCA computer program. Volume 4: Executive summary report

NASA Technical Reports Server (NTRS)

1972-01-01

The functions and capabilities of the Dynamic Operational Requirements and Cost Analysis Program are explained. The existence and purpose of the program are presented to provide an evaluation of program applicability to areas of responsibility for potential users. The implementation of the program on the Univac 1108 computer is discussed. The application of the program for mission planning and project management is described.

Multi-threading: A new dimension to massively parallel scientific computation

NASA Astrophysics Data System (ADS)

Nielsen, Ida M. B.; Janssen, Curtis L.

2000-06-01

Multi-threading is becoming widely available for Unix-like operating systems, and the application of multi-threading opens new ways for performing parallel computations with greater efficiency. We here briefly discuss the principles of multi-threading and illustrate the application of multi-threading for a massively parallel direct four-index transformation of electron repulsion integrals. Finally, other potential applications of multi-threading in scientific computing are outlined.

Closed-Loop Neuropharmacology For Epilepsy: Distant Dream Or Future Reality?

PubMed

Aicua-Rapun, Irene; Andre, Pascal; Novy, Jan

2018-03-08

Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment however is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity. Finally, we consider the pharmacogenetic input in epilepsy treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Lactococcus lactis-based vaccines: current status and future perspectives.

PubMed

Bahey-El-Din, Mohammed; Gahan, Cormac G M

2011-01-01

Lactococcus lactis offers significant potential as a platform for the delivery of vaccines especially via mucosal routes of administration. The organism has an established history of safe use in the food industry and is highly amenable to genetic manipulation, with many systems available for efficient production of secreted and surface-expressed proteins. Here we describe the benefits of using this organism as a vaccine delivery platform and outline how L. lactis based antigen delivery may be improved. Finally we discuss the safe use of L. lactis vectors and outline the potential for use of biological containment systems and killed lactococcal preparations.

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

PubMed Central

Benayoun, Bérénice A.; Pollina, Elizabeth A.; Brunet, Anne

2016-01-01

Preface Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-based epigenetic changes that occur during ageing, the role of chromatin modifiers in modulating lifespan and the importance of epigenetic signatures as biomarkers of ageing. We also discuss how epigenome remodeling by environmental stimuli impacts several aspects of transcription and genomic stability, with important consequences on longevity, and outline epigenetic differences between the ‘mortal soma’ and the ‘immortal germline’. Finally, we discuss the inheritance of ageing characteristics and potential chromatin-based strategies to delay or reverse hallmarks of ageing or age-related diseases. PMID:26373265

Implementation of Headtracking and 3D Stereo with Unity and VRPN for Computer Simulations

NASA Technical Reports Server (NTRS)

Noyes, Matthew A.

2013-01-01

This paper explores low-cost hardware and software methods to provide depth cues traditionally absent in monocular displays. The use of a VRPN server in conjunction with a Microsoft Kinect and/or Nintendo Wiimote to provide head tracking information to a Unity application, and NVIDIA 3D Vision for retinal disparity support, is discussed. Methods are suggested to implement this technology with NASA's EDGE simulation graphics package, along with potential caveats. Finally, future applications of this technology to astronaut crew training, particularly when combined with an omnidirectional treadmill for virtual locomotion and NASA's ARGOS system for reduced gravity simulation, are discussed.

Opioid Receptors: Toward Separation of Analgesic from Undesirable Effects

PubMed Central

Law, P.Y.; Reggio, Patricia H.; Loh, H.H.

2013-01-01

The use of opioid analgesics for pain has always been hampered by their many side effects; in particular, the addictive liability associated with chronic use. Recently, attempts to develop analgesic agents with reduced side effects have targeted either the putative opioid receptor splice variants or the receptor heterooligomers. This review discusses the potential for receptor splice variant- and the hetero-oligomer-based discovery of new opioid analgesics. We also examine an alternative approach of using receptor mutants for pain management. Finally, we discuss the role of the biased agonism observed and the recently reported opioid receptor crystal structures in guiding the future development of opioid analgesics PMID:23598157

Adjunctive therapy in Parkinson’s disease: the role of rasagiline

PubMed Central

Gaines, Kathryn D; Hinson, Vanessa K

2012-01-01

Parkinson’s disease is the second most common neurodegenerative disorder, currently affecting 1.5 million people in the US. In this review, we describe the diagnostic and pathological features of Parkinson’s disease, as well as its clinical course. We then review pharmacologic treatments for the disease, with a particular focus on therapies adjunctive to levodopa and specifically the role of rasagiline. We review the four pivotal rasagiline trials, and discuss rasagiline and its use as adjunctive therapy for Parkinson’s disease. Finally, we discuss potential side effects, drug interactions, and other practical aspects concerning the use of rasagiline in Parkinson’s disease. PMID:22802692

Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network

PubMed Central

Escalante, Ananias A.; Ferreira, Marcelo U.; Vinetz, Joseph M.; Volkman, Sarah K.; Cui, Liwang; Gamboa, Dionicia; Krogstad, Donald J.; Barry, Alyssa E.; Carlton, Jane M.; van Eijk, Anna Maria; Pradhan, Khageswar; Mueller, Ivo; Greenhouse, Bryan; Andreina Pacheco, M.; Vallejo, Andres F.; Herrera, Socrates; Felger, Ingrid

2015-01-01

Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss potential applications of molecular epidemiological tools and methods toward malaria control and elimination efforts. PMID:26259945

Application of Sal classification to parotid gland fine-needle aspiration cytology: 10-year retrospective analysis of 312 patients.

PubMed

Kilavuz, Ahmet Erdem; Songu, Murat; İmre, Abdulkadir; Arslanoğlu, Secil; Özkul, Yilmaz; Pinar, Ercan; Ateş, Düzgün

2018-05-01

The accuracy of fine-needle aspiration biopsy (FNAB) is controversial in parotid tumors. We aimed to compare FNAB results with the final histopathological diagnosis and to apply the "Sal classification" to our data and discuss its results and its place in parotid gland cytology. The FNAB cytological findings and final histological diagnosis were assessed retrospectively in 2 different scenarios based on the distribution of nondefinitive cytology, and we applied the Sal classification and determined malignancy rate, sensitivity, and specificity for each category. In 2 different scenarios FNAB sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were found to be 81%, 87%, 54.7%, and 96.1%; and 65.3%, 100%, 100%, and 96.1%, respectively. The malignancy rates and sensitivity and specificity were also calculated and discussed for each Sal category. We believe that the Sal classification has a great potential to be a useful tool in classification of parotid gland cytology. © 2018 Wiley Periodicals, Inc.

The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It

PubMed Central

Bording-Jorgensen, Michael; Dijk, Stephanie

2018-01-01

Cancer is a multifaceted condition, in which a senescent cell begins dividing in an irregular manner due to various factors such as DNA damage, growth factors and inflammation. Inflammation is not typically discussed as carcinogenic; however, a significant percentage of cancers arise from chronic microbial infections and damage brought on by chronic inflammation. A hallmark cancer-inducing microbe is Helicobacter pylori and its causation of peptic ulcers and potentially gastric cancer. This review discusses the recent developments in understanding microbes in health and disease and their potential role in the progression of cancer. To date, microbes can be linked to almost every cancer, including colon, pancreatic, gastric, and even prostate. We discuss the known mechanisms by which these microbes can induce cancer growth and development and how inflammatory cells may contribute to cancer progression. We also discuss new treatments that target the chronic inflammatory conditions and their associated cancers, and the impact microbes have on treatment success. Finally, we examine common dietary misconceptions in relation to microbes and cancer and how to avoid getting caught up in the misinterpretation and over inflation of the results. PMID:29558443

A Conceptual Framework for Understanding the Association between School Bullying Victimization and Substance Misuse

PubMed Central

Hong, Jun Sung; Davis, Jordan P.; Sterzing, Paul R.; Yoon, Jina; Choi, Shinwoo; Smith, Douglas C.

2014-01-01

This article reviews current research findings and presents a conceptual framework for better understanding the relationship between bullying victimization (hereafter referred to as victimization) and substance misuse (hereafter referred to as SM) among adolescents. Although victimization and SM may appear to be separate problems, research suggests an intriguing relationship between the two. We present a brief, empirical overview of the direct association between victimization and adolescent SM, followed by a proposed conceptual framework that includes co-occurring risk factors for victimization and SM within family, peer, and school/community contexts. Next, we discuss potential mediators linking victimization and SM, such as internalizing problems, traumatic stress, low academic performance, and school truancy/absence. We then identify potential moderating influences of age, gender/sex, social supports, and school connectedness that could amplify or abate the association between victimization and SM. Finally, we discuss practice and policy implications. PMID:25545436

Predictive motor control of sensory dynamics in Auditory Active Sensing

PubMed Central

Morillon, Benjamin; Hackett, Troy A.; Kajikawa, Yoshinao; Schroeder, Charles E.

2016-01-01

Neuronal oscillations present potential physiological substrates for brain operations that require temporal prediction. We review this idea in the context of auditory perception. Using speech as an exemplar, we illustrate how hierarchically organized oscillations can be used to parse and encode complex input streams. We then consider the motor system as a major source of rhythms (temporal priors) in auditory processing, that act in concert with attention to sharpen sensory representations and link them across areas. We discuss the anatomo-functional pathways that could mediate this audio-motor interaction, and notably the potential role of the somatosensory cortex. Finally, we reposition temporal predictions in the context of internal models, discussing how they interact with feature-based or spatial predictions. We argue that complementary predictions interact synergistically according to the organizational principles of each sensory system, forming multidimensional filters crucial to perception. PMID:25594376

The Development and Clinical Evaluation of Second-Generation Leishmaniasis Vaccines

PubMed Central

Duthie, Malcolm S.; Raman, Vanitha S.; Piazza, Franco M.; Reed, Steven G.

2011-01-01

Infection with Leishmania parasites results in a range of clinical manifestations and outcomes. Control of Leishmania parasite transmission is extremely difficult due to the large number of vectors and potential reservoirs, and none of the current treatments are ideal. Vaccination could be an effective strategy to provide sustained control. In this review, the current global situation with regard to leishmaniasis, the immunology of Leishmania infection and various efforts to identify second generation vaccine candidates are briefly discussed. The variety of clinical trials conducted using the only current second generation vaccine approved for clinical use, LEISH-F1 + MPL-SE, are described. Given that epidemiological evidence suggests that reducing the canine reservoir also positively impacts human incidence, efforts at providing a vaccine for leishmaniasis in dogs are highlighted. Finally, potential refinements and surrogate markers that could expedite the introduction of a vaccine that can limit the severity and incidence of leishmaniasis are discussed. PMID:22085553

Update on mucormycosis pathogenesis.

PubMed

Ibrahim, Ashraf S; Kontoyiannis, Dimitrios P

2013-12-01

Mucormycosis is an increasingly common fungal infection with unacceptably high mortality. The recent sequencing genome projects of Mucorales and the development of gene manipulation have enabled significant advances in understanding the pathogenesis of mucormycosis. Therefore, we review the pathogenesis of mucormycosis and highlight potential development of novel diagnostic and therapeutic modalities against this lethal disease. Much of the work has been focused on the role of iron uptake in the virulence of Mucorales. Additionally, host receptors and fungal ligands involved in the process of tissue invasion as well as sporangiospore size and sex loci and their contribution to virulence of Mucorales are discussed. Finally, the role of innate and adaptive immunity in protection against Mucorales and new evidence about drug-induced apoptosis in these fungi are discussed. Recent discoveries introduce several potentially novel diagnostic and therapeutic modalities, which are likely to improve management and outcome for mucormycosis. Future preclinical and clinical research is warranted to develop these diagnostic and therapeutic strategies.

The determination of methane resources from liquidated coal mines

NASA Astrophysics Data System (ADS)

Trenczek, Stanisław

2017-11-01

The article refers to methane presented in hard coal seams, which may pose a serious risk to workers, as evidenced by examples of incidents, and may also be a high energy source. That second issue concerns the possibility of obtaining methane from liquidated coal mines. There is discussed the current methodology for determination of methane resources from hard coal deposits. Methods of assessing methane emissions from hard coal deposits are given, including the degree of rock mass fracture, which is affected and not affected by mining. Additional criteria for methane recovery from the methane deposit are discussed by one example (of many types) of methane power generation equipment in the context of the estimation of potential viable resources. Finally, the concept of “methane resource exploitation from coal mine” refers to the potential for exploitation of the resource and the acquisition of methane for business purposes.

Using Time-of-Flight Secondary Ion Mass Spectrometry to Study Biomarkers

NASA Astrophysics Data System (ADS)

Thiel, Volker; Sjövall, Peter

2011-05-01

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique designed to analyze the composition and spatial distribution of molecules and chemical structures on surfaces. These capabilities have generated much interest in its use in geobiology, in particular for the characterization of organic biomarkers (molecular biosignatures) at the microscopic level. We here discuss the strengths, weaknesses, and potential of ToF-SIMS for biomarker analyses with a focus on applications in geobiology, including biogeochemistry, organic geochemistry, geomicrobiology, and paleobiology. After describing the analytical principles of ToF-SIMS, we discuss issues of biomarker spectral formation and interpretation. Then, key applications of ToF-SIMS to soft (microbial matter, cells), hard (microbial mineral precipitates), and liquid (petroleum) samples relevant in geobiology are reviewed. Finally, we examine the potential of ToF-SIMS in biomarker research and the current limitations and obstacles for which further development would be beneficial to the field.

CASA: tracking the past and plotting the future.

PubMed

Gallagher, M T; Smith, D J; Kirkman-Brown, J C

2018-05-29

The human semen sample carries a wealth of information of varying degrees of accessibility ranging from the traditional visual measures of count and motility to those that need a more computational approach, such as tracking the flagellar waveform. Although computer-aided sperm analysis (CASA) options are becoming more widespread, the gold standard for clinical semen analysis requires trained laboratory staff. In this review we characterise the key attitudes towards the use of CASA and set out areas in which CASA should, and should not, be used and improved. We provide an overview of the current CASA landscape, discussing clinical uses as well as potential areas for the clinical translation of existing research technologies. Finally, we discuss where we see potential for the future of CASA, and how the integration of mathematical modelling and new technologies, such as automated flagellar tracking, may open new doors in clinical semen analysis.

Rationale for Using Social Media to Collect Patient-Reported Outcomes in Patients with Celiac Disease.

PubMed

Park, Kt; Harris, Merissa; Khavari, Nasim; Khosla, Chaitan

2014-02-01

Patients with celiac disease (CD) are increasingly interconnected through social media, exchanging patient experiences and health-tracking information between individuals through various web-based platforms. Social media represents potentially unique communication interface between gastroenterologists and active social media users - especially young adults and adolescents with celiac disease-regarding adherence to the strict gluten-free diet, gastrointestinal symptoms, and meaningful discussion about disease management. Yet, various social media platforms may be underutilized for research purposes to collect patient-reported outcomes data. In this commentary, we summarize the scientific rationale and potential for future growth of social media in patient-reported outcomes research, focusing on college freshmen with celiac disease as a case study and provide overview of the methodological approach. Finally, we discuss how social media may impact patient care in the future through increasing mobile technology use.

Cell separation: Terminology and practical considerations

PubMed Central

Tomlinson, Sophie; Yang, Xuebin B; Kirkham, Jennifer

2013-01-01

Cell separation is a powerful tool in biological research. Increasing usage, particularly within the tissue engineering and regenerative medicine communities, means that researchers from a diverse range of backgrounds are utilising cell separation technologies. This review aims to offer potential solutions to cell sorting problems and to clarify common ambiguities in terminology and experimental design. The frequently used cell separation terms of ‘purity’, ‘recovery’ and ‘viability’ are discussed, and attempts are made to reach a consensus view of their sometimes ambiguous meanings. The importance of appropriate experimental design is considered, with aspects such as marker expression, tissue isolation and original cell population analysis discussed. Finally, specific technical issues such as cell clustering, dead cell removal and non-specific antibody binding are considered and potential solutions offered. The solutions offered may provide a starting point to improve the quality of cell separations achieved by both the novice and experienced researcher alike. PMID:23440031

Analysis of human plasma proteins: a focus on sample collection and separation using free-flow electrophoresis.

PubMed

Nissum, Mikkel; Foucher, Aude L

2008-08-01

Due to ease of accessibility, plasma has become the sample of choice for proteomics studies directed towards biomarker discovery intended for use in diagnostics, prognostics and even in theranostics. The result of these extensive efforts is a long list of potential biomarkers, very few of which have led to clinical utility. Why have so many potential biomarkers failed validation? Herein, we address certain issues encountered, which complicate biomarker discovery efforts originating from plasma. The advantages of stabilizing the sample at collection by the addition of protease inhibitors are discussed. The principles of free-flow electrophoresis (FFE) separation are provided together with examples applying to various studies. Finally, particular attention is given to plasma or serum analysis using multidimensional separation strategies into which the FFE is incorporated. The advantages of using FFE separation in these workflows are discussed.

In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins

PubMed Central

Kurylowicz, Alina

2016-01-01

Most of the available non-invasive medical therapies for obesity are non-efficient in a long-term evaluation; therefore there is a constant need for new methods of treatment. Research on calorie restriction has led to the discovery of sirtuins (silent information regulators, SIRTs), enzymes regulating different cellular pathways that may constitute potential targets in the treatment of obesity. This review paper presents the role of SIRTs in the regulation of glucose and lipid metabolism as well as in the differentiation of adipocytes. How disturbances of SIRTs’ expression and activity may lead to the development of obesity and related complications is discussed. A special emphasis is placed on polymorphisms in genes encoding SIRTs and their possible association with susceptibility to obesity and metabolic complications, as well as on data regarding altered expression of SIRTs in human obesity. Finally, the therapeutic potential of SIRTs-targeted strategies in the treatment of obesity and related disorders is discussed. PMID:27104517

Defect-Engineered Metal–Organic Frameworks

PubMed Central

Fang, Zhenlan; Bueken, Bart; De Vos, Dirk E; Fischer, Roland A

2015-01-01

Defect engineering in metal–organic frameworks (MOFs) is an exciting concept for tailoring material properties, which opens up novel opportunities not only in sorption and catalysis, but also in controlling more challenging physical characteristics such as band gap as well as magnetic and electrical/conductive properties. It is challenging to structurally characterize the inherent or intentionally created defects of various types, and there have so far been few efforts to comprehensively discuss these issues. Based on selected reports spanning the last decades, this Review closes that gap by providing both a concise overview of defects in MOFs, or more broadly coordination network compounds (CNCs), including their classification and characterization, together with the (potential) applications of defective CNCs/MOFs. Moreover, we will highlight important aspects of “defect-engineering” concepts applied for CNCs, also in comparison with relevant solid materials such as zeolites or COFs. Finally, we discuss the future potential of defect-engineered CNCs. PMID:26036179

Unconscious emotion: A cognitive neuroscientific perspective.

PubMed

Smith, Ryan; Lane, Richard D

2016-10-01

While psychiatry and clinical psychology have long discussed the topic of unconscious emotion, and its potentially explanatory role in psychopathology, this topic has only recently begun to receive attention within cognitive neuroscience. In contrast, neuroscientific research on conscious vs. unconscious processes within perception, memory, decision-making, and cognitive control has seen considerable advances in the last two decades. In this article, we extrapolate from this work, as well as from recent neural models of emotion processing, to outline multiple plausible neuro-cognitive mechanisms that may be able to explain why various aspects of one's own emotional reactions can remain unconscious in specific circumstances. While some of these mechanisms involve top-down or motivated factors, others instead arise due to bottom-up processing deficits. Finally, we discuss potential implications that these different mechanisms may have for therapeutic intervention, as well as how they might be tested in future research. Copyright © 2016 Elsevier Ltd. All rights reserved.

Modulation of Kv7 channels and excitability in the brain.

PubMed

Greene, Derek L; Hoshi, Naoto

2017-02-01

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons. We will discuss various factors that have been shown to drastically alter the activity of this channel such as protein and phospholipid interactions, phosphorylation, calcium, and numerous neurotransmitters. Kv7 channels locate to key areas for the control of action potential initiation and propagation. Moreover, we will explore the dynamic surface expression of the channel modulated by neurotransmitters and neural activity. We will also focus on known principle functions of neural Kv7 channels: control of resting membrane potential and spiking threshold, setting the firing frequency, afterhyperpolarization after burst firing, theta resonance, and transient hyperexcitability from neurotransmitter-induced suppression of the M-current. Finally, we will discuss the contribution of altered Kv7 activity to pathologies such as epilepsy and cognitive deficits.

Modulation of Kv7 channels and excitability in the brain

PubMed Central

Greene, Derek L; Hoshi, Naoto

2016-01-01

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons. We will discuss various factors that have been shown to drastically alter the activity of this channel such as protein and phospholipid interactions, phosphorylation, calcium, and numerous neurotransmitters. Kv7 channels locate to key areas for the control of action potential initiation and propagation. Moreover, we will explore the dynamic surface expression of the channel modulated by neurotransmitters and neural activity. We will also focus on known principle functions of neural Kv7 channels: control of resting membrane potential and spiking threshold, setting the firing frequency, afterhyperpolarization after burst firing, theta resonance, and transient hyperexcitability from neurotransmitter-induced suppression of the M-current. Finally, we will discuss the contribution of altered Kv7 activity to pathologies such as epilepsy and cognitive deficits. PMID:27645822

Quasisaddles as relevant points of the potential energy surface in the dynamics of supercooled liquids

NASA Astrophysics Data System (ADS)

Angelani, L.; Di Leonardo, R.; Ruocco, G.; Scala, A.; Sciortino, F.

2002-06-01

The supercooled dynamics of a Lennard-Jones model liquid is numerically investigated studying relevant points of the potential energy surface, i.e., the minima of the square gradient of total potential energy V. The main findings are (i) the number of negative curvatures n of these sampled points appears to extrapolate to zero at the mode coupling critical temperature Tc; (ii) the temperature behavior of n(T) has a close relationship with the temperature behavior of the diffusivity; (iii) the potential energy landscape shows a high regularity in the distances among the relevant points and in their energy location. Finally we discuss a model of the landscape, previously introduced by Madan and Keyes [J. Chem. Phys. 98, 3342 (1993)], able to reproduce the previous findings.

Children's episodic memory.

PubMed

Ghetti, Simona; Lee, Joshua

2011-07-01

Episodic memory develops during childhood and adolescence. This trajectory depends on several underlying processes. In this article, we first discuss the development of the basic binding processes (e.g., the processes by which elements are bound together to form a memory episode) and control processes (e.g., reasoning and metamemory processes) involved in episodic remembering. Then, we discuss the role of these processes in false-memory formation. In the subsequent sections, we examine the neural substrates of the development of episodic memory. Finally, we discuss atypical development of episodic memory. As we proceed through the article, we suggest potential avenues for future research. WIREs Cogni Sci 2011 2 365-373 DOI: 10.1002/wcs.114 For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

Alternative splicing in cancers: From aberrant regulation to new therapeutics.

PubMed

Song, Xiaowei; Zeng, Zhenyu; Wei, Huanhuan; Wang, Zefeng

2018-03-01

Alternative splicing is one of the most common mechanisms for gene regulation in humans, and plays a vital role to increase the complexity of functional proteins. In this article, we seek to provide a general review on the relationships between alternative splicing and tumorigenesis. We briefly introduce the basic rules for regulation of alternative splicing, and discuss recent advances on dynamic regulation of alternative splicing in cancers by highlighting the roles of a variety of RNA splicing factors in tumorigenesis. We further discuss several important questions regarding the splicing of long noncoding RNAs and back-splicing of circular RNAs in cancers. Finally, we discuss the current technologies that can be used to manipulate alternative splicing and serve as potential cancer treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

The status of BAT detector

NASA Astrophysics Data System (ADS)

Lien, Amy; Markwardt, Craig B.; Krimm, Hans Albert; Barthelmy, Scott D.; Cenko, Bradley

2018-01-01

We will present the current status of the Swift/BAT detector. In particular, we will report the updated detector gain calibration, the number of enable detectors, and the global bad time intervals with potential calibration issues. We will also summarize the results of the yearly BAT calibration using the Crab nebula. Finally, we will discuss the effects on the BAT survey, such as the sensitivity, localization, and spectral analysis, due to the changes in detector status.

The Nimbus 4 user's guide

NASA Technical Reports Server (NTRS)

Sabatini, R. R. (Editor)

1970-01-01

Background information on the Nimbus 4 spacecraft and experiments is provided for potential data users as a basis for selecting, obtaining, and utilizing Nimbus 4 data in research studies. The basic spacecraft system operation and the objectives of the Nimbus 4 flight are outlined, with a detailed discussion of each of the experiments included. The format, archiving, and access to the data are also described. Finally, the contents and format of the Nimbus 4 data catalogs are described.

Parallel Hybrid Gas-Electric Geared Turbofan Engine Conceptual Design and Benefits Analysis

NASA Technical Reports Server (NTRS)

Lents, Charles; Hardin, Larry; Rheaume, Jonathan; Kohlman, Lee

2016-01-01

The conceptual design of a parallel gas-electric hybrid propulsion system for a conventional single aisle twin engine tube and wing vehicle has been developed. The study baseline vehicle and engine technology are discussed, followed by results of the hybrid propulsion system sizing and performance analysis. The weights analysis for the electric energy storage & conversion system and thermal management system is described. Finally, the potential system benefits are assessed.

Virtual volatility

NASA Astrophysics Data System (ADS)

Silva, A. Christian; Prange, Richard E.

2007-03-01

We introduce the concept of virtual volatility. This simple but new measure shows how to quantify the uncertainty in the forecast of the drift component of a random walk. The virtual volatility also is a useful tool in understanding the stochastic process for a given portfolio. In particular, and as an example, we were able to identify mean reversion effect in our portfolio. Finally, we briefly discuss the potential practical effect of the virtual volatility on an investor asset allocation strategy.

Modeling of a ring rosen-type piezoelectric transformer by Hamilton's principle.

PubMed

Nadal, Clément; Pigache, Francois; Erhart, Jiří

2015-04-01

This paper deals with the analytical modeling of a ring Rosen-type piezoelectric transformer. The developed model is based on a Hamiltonian approach, enabling to obtain main parameters and performance evaluation for the first radial vibratory modes. Methodology is detailed, and final results, both the input admittance and the electric potential distribution on the surface of the secondary part, are compared with numerical and experimental ones for discussion and validation.

Renewable power production in a Pan-Caribbean energy grid

NASA Astrophysics Data System (ADS)

Miller, David

The Small Island Developing States of the Caribbean are victims of geography and geopolitics. Lacking access to large fossil fuel reserves, they are forced to import fuel at prices they have no control over. Renewable energy resources, particularly wind, have the potential to help break the Caribbean dependency on fossil fuels and allow for increased development at the same time. Working from a sustainable development point of view, this project discusses the history of the area, the theoretical background for the idea of large scale renewable power production, the regional initiatives already in place that address both the cost of fossil fuels and the policy hurdles that need to be overcome to assist the region in gaining energy independence. Haiti is highlighted as a special case in the region and the potential use of several renewable resources are discussed, along with a potential business model based on the idea of the Internet. Power storage is covered, specifically the potential of battery operated vehicles to have a positive impact on the Caribbean region and other developing states. The role of government regulation and policy comes into play next, followed by a discussion on the need for developed states to change patterns of behavior in order to achieve sustainability. Finally, nuclear power and liquefied natural gas are reviewed and rejected as power options for the region.

The re-emergence of sodium ion batteries: testing, processing, and manufacturability

PubMed Central

Roberts, Samuel; Kendrick, Emma

2018-01-01

With the re-emergence of sodium ion batteries (NIBs), we discuss the reasons for the recent interests in this technology and discuss the synergies between lithium ion battery (LIB) and NIB technologies and the potential for NIB as a “drop-in” technology for LIB manufacturing. The electrochemical testing of sodium materials in sodium metal anode arrangements is reviewed. The performance, stability, and polarization of the sodium in these test cells lead to alternative testing in three-electrode and alternative anode cell configurations. NIB manufacturability is also discussed, together with the impact that the material stability has upon the electrodes and coating. Finally, full-cell NIB technologies are reviewed, and literature proof-of-concept cells give an idea of some of the key differences in the testing protocols of these batteries. For more commercially relevant formats, safety, passive voltage control through cell balancing and cell formation aspects are discussed. PMID:29910609

Early detection and intervention for attention-deficit/hyperactivity disorder.

PubMed

Sonuga-Barke, Edmund J S; Koerting, Johanna; Smith, Elizabeth; McCann, Donna C; Thompson, Margaret

2011-04-01

Attention-deficit/hyperactivity disorder (ADHD) is a high-cost/high-burden disorder. Early detection and intervention may prevent or ameliorate the development of the disorder and reduce its long-term impact. In this article, we set out a rationale for an early detection and intervention program. First, we highlight the costs of the condition and second, we discuss the limitations of the current treatments. We then outline the potential value of an early detection and intervention program. We review evidence on predictors of poor outcomes for early ADHD signs and discuss how these might allow us to target early intervention more cost-effectively. We then examine potential barriers to engagement with at-risk samples. This leads to a discussion of possible intervention approaches and how these could be improved. Finally, we describe the Program for Early Detection and Intervention for ADHD (PEDIA), a 5-year program of research supported by the UK National Institute for Health Research and conducted at the University of Southampton (Southampton, UK), which aims to develop and evaluate a strategy for early intervention.

Influence of Human Factor Issues on Patient-Centered mHealth Apps' Impact; Where Do We Stand?

PubMed

Wildenbos, G A; Peute, L W; Jaspers, M W M

2016-01-01

This paper discusses the preliminary results of a literature review on studies published in 2014-2015 concerning patient-centered mHealth applications' (apps) impact. Abstracts were included when they described a mHealth app targeted at patients and reported on the effects of this app on patient care. From a total of 559 potentially relevant articles, 17 papers were finally included. Nine studies reported a positive impact of the patient-centered mHealth app on patient care; 4 of these studies were randomized controlled trials. Measured impacts in the 17 studies focused on improving patients' physical activity, self-efficacy and medication adherence. Human factors issues potentially mediating these effects were discussed in all studies. Transitions in the interaction between healthcare providers and their patients were most often discussed as influencing the impact of the mHealth app. More research is needed, focussing on human issues mediating the effect of patient-centered mHealth apps to precipitate knowledge on the effectiveness of mHealth. This research should preferably be guided by socio-technical models.

STS pilot user development program

NASA Technical Reports Server (NTRS)

Mcdowell, J. R.

1977-01-01

Full exploitation of the STS capabilities will be not only dependent on the extensive use of the STS for known space applications and research, but also on new, innovative ideas of use originating with both current and new users. In recognition of this, NASA has been engaged in a User Development Program for the STS. The program began with four small studies. Each study addressed a separate sector of potential new users to identify techniques and methodologies for user development. The collective results established that a user development function was not only feasible, but necessary for NASA to realize the full potential of the STS. This final report begins with a description of the overall pilot program plan, which involved five specific tasks defined in the contract Statement of Work. Each task is then discussed separately; but two subjects, the development of principal investigators and space processing users, are discussed separately for improved continuity of thought. These discussions are followed by a summary of the primary results and conclusions of the Pilot User Development Program. Specific recommendations of the study are given.

The electrical transport properties of liquid Rb using pseudopotential theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, A. B., E-mail: amit07patel@gmail.com; Bhatt, N. K., E-mail: amit07patel@gmail.com; Thakore, B. Y., E-mail: amit07patel@gmail.com

2014-04-24

Certain electric transport properties of liquid Rb are reported. The electrical resistivity is calculated by using the self-consistent approximation as suggested by Ferraz and March. The pseudopotential due to Hasegawa et al for full electron-ion interaction, which is valid for all electrons and contains the repulsive delta function due to achieve the necessary s-pseudisation was used for the calculation. Temperature dependence of structure factor is considered through temperature dependent potential parameter in the pair potential. Finally, thermo-electric power and thermal conductivity are obtained. The outcome of the present study is discussed in light of other such results, and confirms themore » applicability of pseudopotential at very high temperature via temperature dependent pair potential.« less

Pretest online discussion groups to augment teaching and learning.

PubMed

Kuhn, Jonathan; Hasbargen, Barbara; Miziniak, Halina

2010-01-01

Tests and final examination scores of three semesters of control students in a nursing foundation course were compared with tests and final examination scores of three semesters of participating students. Participating students were offered access to an asynchronous pretest online discussion activity with a faculty e-moderator. While the simplified Bloom's revised taxonomy assisted in creating appropriate preparatory test and final examination questions for pretest online discussion, Salmon's five-stage online method provided direction to the e-moderator on how to encourage students to achieve Bloom's higher-order thinking skills during the pretest online discussions. Statistical analysis showed the pretest online discussion activity had a generally positive impact on tests and final examination scores, when controlling for a number of possible confounding variables, including instructor, cumulative grade point average, age, and credit hours.

The local work function: Concept and implications

NASA Astrophysics Data System (ADS)

Wandelt, K.

1997-02-01

The term 'local work function' is now widely applied. The present work discusses the common physical basis of 'photoemission of adsorbed xenon (PAX)' and 'two-photon photonemissionspectroscopy of image potential states' as local work function probes. New examples with bimetallic and defective surfaces are presented which demonstrate the capability of PAX measurements for the characterization of heterogeneous surfaces on an atomic scale. Finally, implications of the existence of short-range variations of the surface potential at surface steps are addressed. In particular, dynamical work function change measurements are a sensitive probe for the step-density at surfaces and, as such, a powerful in-situ method to monitor film growth.

A Framework for Safe Integration of Small UAS Into the NAS

NASA Technical Reports Server (NTRS)

Logan, Michael J.; Bland, Geoffrey; Murray, Jennifer

2011-01-01

This paper discusses a proposed framework for the safe integration of small unmanned aerial systems (sUAS) into the National Airspace System (NAS). The paper examines the potential uses of sUAS to build an understanding of the location and frequency of potential future flight operations based on the future applications of the sUAS systems. The paper then examines the types of systems that would be required to meet the application-level demand to determine classes of platforms and operations. Finally, a framework is proposed for both airworthiness and operations that attempts to balance safety with utility for these important systems.

Effect of helminth-induced immunity on infections with microbial pathogens

PubMed Central

2016-01-01

Helminth infections are ubiquitous worldwide and can trigger potent immune responses that differ from and potentially antagonize host protective responses to microbial pathogens. In this Review we focus on the three main killers in infectious disease—AIDS, tuberculosis and malaria—and critically assesses whether helminths adversely influence host control of these diseases. We also discuss emerging concepts for how M2 macrophages and helminth-modulated dendritic cells can potentially influence the protective immune response to concurrent infections. Finally, we present evidence advocating for more efforts to determine how and to what extent helminths interfere with the successful control of specific concurrent coinfections. PMID:24145791

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches.

PubMed

Zhang, Xi-Feng; Liu, Zhi-Guo; Shen, Wei; Gurunathan, Sangiliyandi

2016-09-13

Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. AgNPs play an important role in nanoscience and nanotechnology, particularly in nanomedicine. Although several noble metals have been used for various purposes, AgNPs have been focused on potential applications in cancer diagnosis and therapy. In this review, we discuss the synthesis of AgNPs using physical, chemical, and biological methods. We also discuss the properties of AgNPs and methods for their characterization. More importantly, we extensively discuss the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti-cancer activity of AgNPs. In addition, we discuss therapeutic approaches and challenges for cancer therapy using AgNPs. Finally, we conclude by discussing the future perspective of AgNPs.

Recognition of LPS by TLR4: Potential for Anti-Inflammatory Therapies

PubMed Central

Nijland, Reindert; Hofland, Tom; van Strijp, Jos A. G.

2014-01-01

LPS molecules of marine bacteria show structures distinct from terrestrial bacteria, due to the different environment that marine bacteria live in. Because of these different structures, lipid A molecules from marine bacteria are most often poor stimulators of the Toll-like receptor 4 (TLR4) pathway. Due to their low stimulatory potential, these lipid A molecules are suggested to be applicable as antagonists of TLR4 signaling in sepsis patients, where this immune response is amplified and unregulated. Antagonizing lipid A molecules might be used for future therapies against sepsis, therapies that currently do not exist. In this review, we will discuss these differences in lipid A structures and their recognition by the immune system. The modifications present in marine lipid A structures are described, and their potential as LPS antagonists will be discussed. Finally, since clinical trials built on antagonizing lipid A molecules have proven unsuccessful, we propose to also focus on different aspects of the TLR4 signaling pathway when searching for new potential drugs. Furthermore, we put forward the notion that bacteria probably already produce inhibitors of TLR4 signaling, making these bacterial products interesting molecules to investigate for future sepsis therapies. PMID:25056632

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

PubMed Central

Khattab, Ahmad; Islam, Mohammad Ariful; Hweij, Khaled Abou; Zeitouny, Joya; Waters, Renae; Sayegh, Malek; Hossain, Md Monowar; Paul, Arghya

2015-01-01

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI. PMID:27668147

Relating empathy and emotion regulation: do deficits in empathy trigger emotion dysregulation?

PubMed

Schipper, Marc; Petermann, Franz

2013-01-01

Emotion regulation is a crucial skill in adulthood; its acquisition represents one of the key developmental tasks in early childhood. Difficulties with adaptive emotion regulation increase the risk of psychopathology in childhood and adulthood. This is, for instance, shown by a relation between emotion regulation and aggressive behavior in childhood age, indicating emotion dysregulation as an important risk factor of aggressive behavior and potential precursor of psychopathology. Based on (1) interrelations between emotion processes and social information processing (maladaptive emotion regulation and social information processing are associated with higher levels of aggression) and (2) recent neuroscientific findings showing that empathy deficits might not only result in difficulties labeling others' emotions but one's own emotions too, we suggest that empathy deficits might serve as potential trigger of emotion dysregulation. Different studies investigating the relation between empathy and emotion regulation are presented and discussed. Discussions are based on the assumed potential of empathy deficits triggering emotion dysregulation. Furthermore, developmental neuroscientific findings on empathy and emotion regulation are highlighted which provide further insights on how these processes might relate. Finally, possible directions for future research are presented.

Agent-based modeling as a tool for program design and evaluation.

PubMed

Lawlor, Jennifer A; McGirr, Sara

2017-12-01

Recently, systems thinking and systems science approaches have gained popularity in the field of evaluation; however, there has been relatively little exploration of how evaluators could use quantitative tools to assist in the implementation of systems approaches therein. The purpose of this paper is to explore potential uses of one such quantitative tool, agent-based modeling, in evaluation practice. To this end, we define agent-based modeling and offer potential uses for it in typical evaluation activities, including: engaging stakeholders, selecting an intervention, modeling program theory, setting performance targets, and interpreting evaluation results. We provide demonstrative examples from published agent-based modeling efforts both inside and outside the field of evaluation for each of the evaluative activities discussed. We further describe potential pitfalls of this tool and offer cautions for evaluators who may chose to implement it in their practice. Finally, the article concludes with a discussion of the future of agent-based modeling in evaluation practice and a call for more formal exploration of this tool as well as other approaches to simulation modeling in the field. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Lowe-Andersen thermostat as an alternative to the dissipative particle dynamics in the mesoscopic simulation of entangled polymers.

PubMed

Khani, Shaghayegh; Yamanoi, Mikio; Maia, Joao

2013-05-07

Dissipative Particle Dynamics (DPD) has shown a great potential in studying the dynamics and rheological properties of soft matter; however, it is associated with deficiencies in describing the characteristics of entangled polymer melts. DPD deficiencies are usually correlated to the time integrating method and the unphysical bond crossings due to utilization of soft potentials. One shortcoming of DPD thermostat is the inability to produce real values of Schmidt number for fluids. In order to overcome this, an alternative Lowe-Anderson (LA) method, which successfully stabilizes the temperature, is used in the present work. Additionally, a segmental repulsive potential was introduced to avoid unphysical bond crossings. The performance of the method in simulating polymer systems is discussed by monitoring the static and dynamic characteristics of polymer chains and the results from the LA method are compared to standard DPD simulations. The performance of the model is evaluated on capturing the main shear flow properties of entangled polymer systems. Finally the linear and nonlinear viscoelastic properties of such systems are discussed.

Advanced Neuroimaging in Traumatic Brain Injury

PubMed Central

Edlow, Brian L.; Wu, Ona

2013-01-01

Advances in structural and functional neuroimaging have occurred at a rapid pace over the past two decades. Novel techniques for measuring cerebral blood flow, metabolism, white matter connectivity, and neural network activation have great potential to improve the accuracy of diagnosis and prognosis for patients with traumatic brain injury (TBI), while also providing biomarkers to guide the development of new therapies. Several of these advanced imaging modalities are currently being implemented into clinical practice, whereas others require further development and validation. Ultimately, for advanced neuroimaging techniques to reach their full potential and improve clinical care for the many civilians and military personnel affected by TBI, it is critical for clinicians to understand the applications and methodological limitations of each technique. In this review, we examine recent advances in structural and functional neuroimaging and the potential applications of these techniques to the clinical care of patients with TBI. We also discuss pitfalls and confounders that should be considered when interpreting data from each technique. Finally, given the vast amounts of advanced imaging data that will soon be available to clinicians, we discuss strategies for optimizing data integration, visualization and interpretation. PMID:23361483

Alcohol Versus Cannabinoids: A Review of Their Opposite Neuro-Immunomodulatory Effects and Future Therapeutic Potentials

PubMed Central

Nair, Madhavan P.; Figueroa, Gloria; Casteleiro, Gianna; Muñoz, Karla; Agudelo, Marisela

2015-01-01

Due to the legalization of marijuana and the increased demand for cannabis and alcohol consumption, research efforts highlighting the biomedical consequences of the use of alcohol and cannabinoids are not only relevant to the substance abuse scientific field, but are also of public health interest. Moreover, an overview of the recent literature about alcohol and cannabinoids neuro-immunomodulatory effects highlighting their future therapeutic potentials will provide a significant contribution to science and medicine. Therefore, in the current review, we will first discuss briefly the prevalence of alcohol and marijuana abuse, followed by a discussion on the individual effects of alcohol and cannabinoids on the immune system; then, we will focus on the role of endocannabinoids on the alcohol-induced inflammatory effects. In addition, the review also incorporates cytokine array data obtained from human monocyte-derived dendritic cells, providing a different perspective on the alcohol and cannabinoid abuse divergent effects on cytokine production. The final section will highlight the therapeutic potential of cannabinoid receptors and the novel strategies to treat alcohol dependence as determined by in vitro, in vivo and clinical studies. PMID:26478902

Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration

PubMed Central

Short, Aaron R.; Koralla, Deepthi; Deshmukh, Ameya; Wissel, Benjamin; Stocker, Benjamin; Calhoun, Mark; Dean, David; Winter, Jessica O.

2015-01-01

Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success of the current “gold standard” treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate bone stock. There is thus a critical need for the development of new, engineered materials for bone repair. This review describes the use of natural and synthetic hydrogels as scaffolds for bone tissue engineering. We discuss many of the advantages that hydrogels offer as bone repair materials, including their potential for osteoconductivity, biodegradability, controlled growth factor release, and cell encapsulation. We also discuss the use of hydrogels in composite devices with metals, ceramics, or polymers. These composites are useful because of the low mechanical moduli of hydrogels. Finally, the potential for thermosetting and photo-cross-linked hydrogels as three-dimensionally (3D) printed, patient-specific devices is highlighted. Three-dimensional printing enables controlled spatial distribution of scaffold materials, cells, and growth factors. Hydrogels, especially natural hydrogels present in bone matrix, have great potential to augment existing bone tissue engineering devices for the treatment of critical size bone defects. PMID:26693013

Biology and management of insect pests in North American intensively managed hardwood forest systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coyle, David R.; Nebeker, T., E.; Hart, E., R.

2005-01-01

Annu. Rev. Entomol. 50:1-29. Abstract Increasing demand for wood and wood products is putting stress on traditional forest production areas, leading to long-term economic and environmental concerns. Intensively managed hardwood forest systems (IMHFS), grown using conventional agricultural as well as forestry methods, can help alleviate potential problems in natural forest production areas. Although IMHFS can produce more biomass per hectare per year than natural forests, the ecologically simplified, monocultural systems may greatly increase the crops susceptibility to pests. Species in the genera Populus and Salix comprise the greatest acreage in IMHFS in North America, but other species, including Liquidambar styracifuamore » and Platanus occidentalis, are also important. We discuss life histories, realized and potential damage, and management options for the most economically infuential pests that affect these hardwood species. The substantial inherent challenges associated with pest management in the monocultural environments created by IMHFS are reviewed. Finally, we discuss ways to design IMHFS that may reduce their susceptibility to pests, increase their growth and productivity potential, and create a more sustainable environment.« less

Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration.

PubMed

Short, Aaron R; Koralla, Deepthi; Deshmukh, Ameya; Wissel, Benjamin; Stocker, Benjamin; Calhoun, Mark; Dean, David; Winter, Jessica O

2015-10-28

Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success of the current "gold standard" treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate bone stock. There is thus a critical need for the development of new, engineered materials for bone repair. This review describes the use of natural and synthetic hydrogels as scaffolds for bone tissue engineering. We discuss many of the advantages that hydrogels offer as bone repair materials, including their potential for osteoconductivity, biodegradability, controlled growth factor release, and cell encapsulation. We also discuss the use of hydrogels in composite devices with metals, ceramics, or polymers. These composites are useful because of the low mechanical moduli of hydrogels. Finally, the potential for thermosetting and photo-cross-linked hydrogels as three-dimensionally (3D) printed, patient-specific devices is highlighted. Three-dimensional printing enables controlled spatial distribution of scaffold materials, cells, and growth factors. Hydrogels, especially natural hydrogels present in bone matrix, have great potential to augment existing bone tissue engineering devices for the treatment of critical size bone defects.

Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy.

PubMed

Smith, Emily; Zhou, Wei; Shindiapina, Polina; Sif, Said; Li, Chenglong; Baiocchi, Robert A

2018-05-21

Exploration in the field of epigenetics has revealed the diverse roles of the protein arginine methyltransferase (PRMT) family of proteins in multiple disease states. These findings have led to the development of specific inhibitors and discovery of several new classes of drugs with potential to treat both benign and malignant conditions. Areas covered: We provide an overview on the role of PRMT enzymes in healthy and malignant cells, highlighting the role of arginine methylation in specific pathways relevant to cancer pathogenesis. Additionally, we describe structure and catalytic activity of PRMT and discuss the mechanisms of action of novel small molecule inhibitors of specific members of the arginine methyltransferase family. Expert opinion: As the field of PRMT biology advances, it's becoming clear that this class of enzymes is highly relevant to maintaining normal physiologic processes as well and disease pathogenesis. We discuss the potential impact of PRMT inhibitors as a broad class of drugs, including the pleiotropic effects, off target effects the need for more detailed PRMT-centric interactomes, and finally, the potential for targeting this class of enzymes in clinical development of experimental therapeutics for cancer.

Status of Complex Langevin

NASA Astrophysics Data System (ADS)

Seiler, Erhard

2018-03-01

I review the status of the Complex Langevin method, which was invented to make simulations of models with complex action feasible. I discuss the mathematical justification of the procedure, as well as its limitations and open questions. Various pragmatic measures for dealing with the existing problems are described. Finally I report on the progress in the application of the method to QCD, with the goal of determining the phase diagram of QCD as a function of temperature and baryonic chemical potential.

Medicolegal Implications of Common Rhinologic Medications.

PubMed

Poetker, David M; Smith, Timothy L

2015-10-01

As otolaryngologists, we prescribe many medications to our patients. The objective of this article is to review the potential side effects and medicolegal risks of the common medications used to treat chronic rhinosinusitis. The authors evaluate some of the common side effects as well as the published literature on the lawsuits associated with those medications. Finally, the authors review the informed consent discussion and opportunities to improve patient care and decrease the risk of litigation. Published by Elsevier Inc.

Energy Partitioning and Impulse Dispersion in the Decorated, Tapered, Strongly Nonlinear Granular Alignment: A System with Many Potential Applications

DTIC Science & Technology

2010-03-01

finally discuss some preliminary experimental results using systems with chrome spheres and small Nitinol interstitial grains to present the... Nitinol interstitial grains to present the underlying nonlinear dynamics of this so-called decorated tapered granular alignment. We are specifically...second was the DTC setup. In this case, small Nitinol 2.38 mm diameter particles were in- troduced between the main STC particles so that NDTC=9. 53 The

Feasibility Standards for Communicative Skills: Final Report for the U.S. Army Training and Doctrine Command

DTIC Science & Technology

1992-01-27

was found for the interrelatedness of these skills (the "whole language" approach). However, it is a complex relationship , and there remain...the comprehensive annotated bibliography. It does not include discussions of writing or speaking anxiety; psychomotor skills ; or potential bias, such... relationship and how the communicative skills program will be implemented. The only way to determine that which is useful from that which is not is

Analysis of requirements for accelerating the development of geothermal energy resources in California

NASA Technical Reports Server (NTRS)

Fredrickson, C. D.

1978-01-01

Various resource data are presented showing that geothermal energy has the potential of satisfying a singificant part of California's increasing energy needs. General factors slowing the development of geothermal energy in California are discussed and required actions to accelerate its progress are presented. Finally, scenarios for developing the most promising prospects in the state directed at timely on-line power are given. Specific actions required to realize each of these individual scenarios are identified.

Engineering of head-mounted projective displays.

PubMed

Hua, H; Girardot, A; Gao, C; Rolland, J P

2000-08-01

Head-mounted projective displays (HMPD's) are a novel type of head-mounted display. A HMPD consists of a miniature projection lens mounted upon the user's head and retroreflective sheeting material placed strategically in the environment. First, the imaging concept of a HMPD is reviewed and its potential advantages and disadvantages are discussed. The design and a bench prototype implementation are then presented. Finally, the effects of retroreflective materials on the imaging properties and the optical properties of HMPD's are comprehensively investigated.

A preliminary review of coal exploration activities conducted by the government of Armenia and the coal resource potential of Armenia

USGS Publications Warehouse

Warwick, Peter D.; Pierce, B.S.; Landis, E.R.

1993-01-01

A coal resource assessment team from the U.S. Geological Survey (USGS), in cooperation with the Armenian Department of Underground Resources (DUR) and elements of the Ministry of Energy and Fuel, has completed an initial visit to Armenia under the auspices of the U.S. Agency for International Development JUSAID). The visit included discussions of the coal resources, identification of problems associated with on-going exploration and development activities, and field visits to selected solid fuel areas. The USGS team will return in November with a draft of the final report for discussion of conclusions and recommendations with Armenian counterparts, representatives of USAID, and the American Embassy. The final report, which will contain tabulated coal-sample analytical results and detailed recommendations, will be submitted to the USAID by the end of December 1993.Preliminary conclusions are that: 1) Armenia has usable deposits of coal that could form a viable, though relatively small, component of Armenia's energy budget; 2) on-going exploration and development activities must be augmented and expedited to increase understanding of the coal resource potential and subsequent utilization; 3) deficiencies in supplies (primarily fuel) and equipment (replacement of aging parts and units) have greatly reduced the gathering of necessary resource data; and 4) training of Armenian counterparts in conducting and managing coal exploration activities is desirable.

Local control theory using trajectory surface hopping and linear-response time-dependent density functional theory.

PubMed

Curchod, Basile F E; Penfold, Thomas J; Rothlisberger, Ursula; Tavernelli, Ivano

2013-01-01

The implementation of local control theory using nonadiabatic molecular dynamics within the framework of linear-response time-dependent density functional theory is discussed. The method is applied to study the photoexcitation of lithium fluoride, for which we demonstrate that this approach can efficiently generate a pulse, on-the-fly, able to control the population transfer between two selected electronic states. Analysis of the computed control pulse yields insights into the photophysics of the process identifying the relevant frequencies associated to the curvature of the initial and final state potential energy curves and their energy differences. The limitations inherent to the use of the trajectory surface hopping approach are also discussed.

Airframe self-noise: Four years of research. [aircraft noise reduction for commercial aircraft

NASA Technical Reports Server (NTRS)

Hardin, J. C.

1976-01-01

A critical assessment of the state of the art in airframe self-noise is presented. Full-scale data on the intensity, spectra and directivity of this noise source are evaluated in the light of the comprehensive theory developed by Ffowcs-Williams and Hawkins. Vibration of panels on commercial aircraft is identified as a possible additional source of airframe noise. The present understanding and methods for prediction of other component sources - airfoils, struts, and cavities - are discussed, and areas for further research as well as potential methods for airframe noise reduction are identified. Finally, the various experimental methods which have been developed for airframe noise research are discussed and sample results are presented.

Techniques for shuttle trajectory optimization

NASA Technical Reports Server (NTRS)

Edge, E. R.; Shieh, C. J.; Powers, W. F.

1973-01-01

The application of recently developed function-space Davidon-type techniques to the shuttle ascent trajectory optimization problem is discussed along with an investigation of the recently developed PRAXIS algorithm for parameter optimization. At the outset of this analysis, the major deficiency of the function-space algorithms was their potential storage problems. Since most previous analyses of the methods were with relatively low-dimension problems, no storage problems were encountered. However, in shuttle trajectory optimization, storage is a problem, and this problem was handled efficiently. Topics discussed include: the shuttle ascent model and the development of the particular optimization equations; the function-space algorithms; the operation of the algorithm and typical simulations; variable final-time problem considerations; and a modification of Powell's algorithm.

Kamstrupp's wow-effect: re-examined and expanded

NASA Astrophysics Data System (ADS)

King, Elizabeth M.; Dickmann, Ellyn M.; Johnson, Barbara Z.

2016-12-01

This review examines Anne Katrine Kamstrupp's article "The wow-effect in science teacher education; technology; sociomateriality." In the discussion below we explore three key areas of her ethnographic research. First, we reconsider Kamstrupp's article through the lens of technology as a pedagogical choice and philosophy. This is followed by our discussion of aspects of her study within the context of a basic understanding that entry-level pre-service teachers need to fully understand both the process of learning and scientific principles as these are important foundational factors in determining whether or not the wow-effect will occur as expected. Finally, our review team presents multiple areas in Kamstrupp's article as potential points for further elaboration.

Modulated Electron Emission by Scattering-Interference of Primary Electrons

NASA Astrophysics Data System (ADS)

Valeri, Sergio; di Bona, Alessandro

We review the effects of scattering-interference of the primary, exciting beam on the electron emission from ordered atomic arrays. The yield of elastically and inelastically backscattered electrons, Auger electrons and secondary electrons shows a marked dependence on the incidence angle of primary electrons. Both the similarity and the relative importance of processes experienced by incident and excident electrons are discussed. We also present recent studies of electron focusing and defocusing along atomic chains. The interplay between these two processes determines the in-depth profile of the primary electron intensity anisotropy. Finally, the potential for surface-structural studies and limits for quantitative analysis are discussed, in comparison with the Auger electron diffraction (AED) and photoelectron diffraction (PD) techniques.

Aerogels in Chemical Engineering: Strategies Toward Tailor-Made Aerogels.

PubMed

Smirnova, Irina; Gurikov, Pavel

2017-06-07

The present review deals with recent advances in the rapidly growing field of aerogel research and technology. The major focus of the review lies in approaches that allow tailoring of aerogel properties to meet application-driven requirements. The decisive properties of aerogels are discussed with regard to existing and potential application areas. Various tailoring strategies, such as modulation of the pore structure, coating, surface modification, and post-treatment, are illustrated by results of the last decade. In view of commercialization of aerogel-based products, a panorama of current industrial aerogel suppliers is given, along with a discussion of possible alternative sources for raw materials and precursors. Finally, growing points and perspectives of the aerogel field are summarized.

Progress with new malaria vaccines.

PubMed Central

Webster, Daniel; Hill, Adrian V. S.

2003-01-01

Malaria is a parasitic disease of major global health significance that causes an estimated 2.7 million deaths each year. In this review we describe the burden of malaria and discuss the complicated life cycle of Plasmodium falciparum, the parasite responsible for most of the deaths from the disease, before reviewing the evidence that suggests that a malaria vaccine is an attainable goal. Significant advances have recently been made in vaccine science, and we review new vaccine technologies and the evaluation of candidate malaria vaccines in human and animal studies worldwide. Finally, we discuss the prospects for a malaria vaccine and the need for iterative vaccine development as well as potential hurdles to be overcome. PMID:14997243

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Jiang-Hao

In original twin Higgs model, vacuum misalignment between electroweak and new physics scales is realized by adding explicit Z 2 breaking term. Introducing additional twin Higgs could accommodate spontaneous Z 2 breaking, which explains origin of this misalignment. We introduce a class of twin two Higgs doublet models with most general scalar potential, and discuss general conditions which trigger electroweak and Z 2 symmetry breaking. Various scenarios on realising the vacuum misalignment are systematically discussed in a natural composite two Higgs double model framework: explicit Z 2 breaking, radiative Z 2 breaking, tadpole-induced Z 2 breaking, and quartic-induced Z 2more » breaking. Finally, we investigate the Higgs mass spectra and Higgs phenomenology in these scenarios.« less

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

PubMed Central

Webster, Christopher P.; Smith, Emma F.; Shaw, Pamela J.; De Vos, Kurt J.

2017-01-01

Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells. Proteostasis requires an intricate network of protein quality control pathways (the proteostasis network) that work to prevent protein aggregation and maintain proteome health throughout the lifespan of the cell. Collapse of proteostasis has been implicated in the etiology of a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disorder. Here, we review the evidence linking dysfunctional proteostasis to the etiology of ALS and discuss how ALS-associated insults affect the proteostasis network. Finally, we discuss the potential therapeutic benefit of proteostasis network modulation in ALS. PMID:28512398

Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.

PubMed

Escalante, Ananias A; Ferreira, Marcelo U; Vinetz, Joseph M; Volkman, Sarah K; Cui, Liwang; Gamboa, Dionicia; Krogstad, Donald J; Barry, Alyssa E; Carlton, Jane M; van Eijk, Anna Maria; Pradhan, Khageswar; Mueller, Ivo; Greenhouse, Bryan; Pacheco, M Andreina; Vallejo, Andres F; Herrera, Socrates; Felger, Ingrid

2015-09-01

Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second, we describe and compare different parasite genotyping methods commonly used in malaria epidemiology and population genetics. Finally, we discuss potential applications of molecular epidemiological tools and methods toward malaria control and elimination efforts. © The American Society of Tropical Medicine and Hygiene.

Mixing qualitative and quantitative research in developmental science: uses and methodological choices.

PubMed

Yoshikawa, Hirokazu; Weisner, Thomas S; Kalil, Ariel; Way, Niobe

2008-03-01

Multiple methods are vital to understanding development as a dynamic, transactional process. This article focuses on the ways in which quantitative and qualitative methodologies can be combined to enrich developmental science and the study of human development, focusing on the practical questions of "when" and "how." Research situations that may be especially suited to mixing qualitative and quantitative approaches are described. The authors also discuss potential choices for using mixed quantitative- qualitative approaches in study design, sampling, construction of measures or interview protocols, collaborations, and data analysis relevant to developmental science. Finally, they discuss some common pitfalls that occur in mixing these methods and include suggestions for surmounting them.

The versatile biopolymer chitosan: potential sources, evaluation of extraction methods and applications.

PubMed

Kaur, Surinder; Dhillon, Gurpreet Singh

2014-05-01

Among the biopolymers, chitin and its derivative chitosan (CTS) have been receiving increasing attention. Both are composed of randomly distributed β-(1-4)-linked d-glucosamine and N-acetyl glucosamine units. On commercial scale, CTS is mainly obtained from the crustacean shells. The chemical methods employed for extraction of CTS from crustacean shells are laden with many disadvantages. Waste fungal biomass represents a potential biological source of CTS, in fact with superior physico-chemical properties, such as high degree of deacetylation, low molecular weight, devoid of protein contamination and high bioactivity. Researchers around the globe are attempting to commercialize CTS production and extraction from fungal sources. Fungi are promising and environmentally benign source of CTS and they have the potential to completely replace crustacean-derived CTS. Waste fungal biomass resulting from various pharmaceutical and biotechnological industries is grown on inexpensive agro-industrial wastes and its by-products are a rich and inexpensive source of CTS. CTS is emerging as an important natural polymer having broad range of applications in different fields. In this context, the present review discusses the potential sources of CTS and their advantages and disadvantages. This review also deals with potential applications of CTS in different fields. Finally, the various attributes of CTS sought in different applications are discussed.

Recent advances in the treatment of erectile dysfunction.

PubMed

Mobley, David F; Khera, Mohit; Baum, Neil

2017-11-01

Erectile dysfunction (ED) is one of the most common conditions affecting middle-aged and older men. Nearly every primary care physician, internist and geriatrician will be called upon to manage this condition or to make referrals to urologists, endocrinologists and cardiologists who will assist in the treatment of ED. This article will briefly discuss the diagnosis and management of ED. In addition, emerging concepts in ED management will be discussed, such as the use of testosterone to treat ED, the role of the endothelium in men with ED and treating the partner of the man with ED. Finally, future potential therapies for ED will be discussed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Some observations on the use of discriminant analysis in ecology

USGS Publications Warehouse

Williams, B.K.

1983-01-01

The application of discriminant analysis in ecological investigations is discussed. The appropriate statistical assumptions for discriminant analysis are illustrated, and both classification and group separation approaches are outlined. Three assumptions that are crucial in ecological studies are discussed at length, and the consequences of their violation are developed. These assumptions are: equality of dispersions, identifiability of prior probabilities, and precise and accurate estimation of means and dispersions. The use of discriminant functions for purposes of interpreting ecological relationships is also discussed. It is suggested that the common practice of imputing ecological 'meaning' to the signs and magnitudes of coefficients be replaced by an assessment of 'structure coefficients.' Finally, the potential and limitations of representation of data in canonical space are considered, and some cautionary points are made concerning ecological interpretation of patterns in canonical space.

Recent developments in aircraft protection systems for laser guide star operations

NASA Astrophysics Data System (ADS)

Stomski, Paul J.; Murphy, Thomas W.; Campbell, Randy

2012-07-01

The astronomical community's use of high power laser guide star adaptive optics (LGS-AO) systems presents a potential hazard to aviation. Historically, the most common and trusted means of protecting aircraft and their occupants has been the use of safety observers (aka spotters) armed with shut-off switches. These safety observers watch for aircraft at risk and terminate laser propagation before the aircraft can be adversely affected by the laser. Efforts to develop safer and more cost-effective automated aircraft protection systems for use by the astronomical community have been inhibited by both technological and regulatory challenges. This paper discusses recent developments in these two areas. Specifically, with regard to regulation and guidance we discuss the 2011 release of AS-6029 by the SAE as well as the potential impact of RTCA DO-278A. With regard to the recent developments in the technology used to protect aircraft from laser illumination, we discuss the novel Transponder Based Aircraft Detection (TBAD) system being installed at W. M. Keck Observatory (WMKO). Finally, we discuss our strategy for evaluating TBAD compliance with the regulations and for seeking appropriate approvals for LGS operations at WMKO using a fully automated, flexibly configured, multi-tier aircraft protection system incorporating this new technology.

The Consequences of Vagueness in Consent to Organ Donation.

PubMed

Shaw, David M

2017-07-01

In this article I argue that vagueness concerning consent to post-mortem organ donation causes considerable harm in several ways. First, the information provided to most people registering as organ donors is very vague in terms of what is actually involved in donation. Second, the vagueness regarding consent to donation increases the distress of families of patients who are potential organ donors, both during and following the discussion about donation. Third, vagueness also increases the chances that the patient's intention to donate will not be fulfilled due to the family's distress. Fourth, the consequent reduction in the number of donated organs leads to avoidable deaths and increased suffering among potential recipients, and distresses them and their families. There are three strategies which could be used to reduce the harmful effects of this vagueness. First, recategorizing the reasons (commonly referred to as 'overrules' under the current system) given by families who refuse donation from registered donors would bring greater clarity to donation discussions. Second, people who wish to donate their organs should be encouraged to discuss their wishes in detail with their families, and to consider recording their wishes in other ways. Finally, the consent system for organ donation could be made more detailed, ensuring both that more information is provided to potential donors and that they have more flexibility in how their intentions are indicated; this last strategy, however, could have the disadvantage of discouraging some potential donors from registering. © 2016 John Wiley & Sons Ltd.

Existence of bound states of a polaron with a breather in soft potentials

NASA Astrophysics Data System (ADS)

Cuevas, J.; Kevrekidis, P. G.; Frantzeskakis, D. J.; Bishop, A. R.

2006-08-01

We consider polarons in models of coupled electronic and vibrational degrees of freedom, in the presence of a soft nonlinear substrate potential (Morse potential). In particular, we focus on a bound state of a polaron with a breather, a so-called “polarobreather.” We analyze the existence of these states based on frequency resonance conditions and illustrate their stability using Floquet spectrum techniques. Multisite solutions of this type are also obtained both in the stationary case (bond-centered and twisted polarons) and in the breathing case (bond-centered and twisted polarobreathers). For all the branches examined, the dynamical evolution of instabilities pertinent to the corresponding solutions are also briefly discussed. Finally, a different branch of so-called phantom polarobreathers is also demonstrated.

In-flight Far-Infrared Performance of the CIRS Instrument on Cassini

NASA Technical Reports Server (NTRS)

Nixon, Conor A.; Brasunas, John C.; Lakew, Brook; Fettig, Rainer; Jennings, Donald E.; Carlson, Ronald; Kunde, Virgil G.

2004-01-01

The Composite Infrared Spectrometer (CIRS) on-board Cassini consists of two interferometers: a conventional Michelson for the mid-infrared; and a Martin-Puplett type in the far-infrared employing wire grid polarizers to split, recombine and analyze the radiation. The far-IR focal plane (FP1) assembly uses two thermopile detectors to measure the final transmitted and reflected beams at the polarizer-analyzer: if one fails, the interferometer can still operate, albeit with a lower efficiency. The combined effect is for good response from 10 to 300/cm, and declining response to 600/cm. This paper will examine in-flight performance of the far-IR interferometer, including NESR and response. Regular noise spikes, resulting from pickup from other electrical sub-systems has been found on the CIRS interferograms, and the removal of these effects is discussed. The radiometric calibration is described, and then we show how the calibration was applied to science data taken during the Jupiter flyby of December 2000. Finally, we discuss signal-to-noise on the calibrated spectra, emphasizing limitations of the current instrument and the potential for improvement in future missions.

Lead-acid batteries in solar photovoltaic power systems for marine aids to navigation. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trenchard, S.E.

1981-10-01

Since 1974, the U.S. Coast Guard has been testing lead-acid batteries in solar photovoltaic-powered systems for aids to navigation. Three types of lead-acid batteries, distinguished by the composition of their grid material, have been tested: lead-antimony grid, lead-calcium grid, and pure-lead grid. This report contains a comparison of the charging characteristics and the charge-discharge cycling behavior of each grid type. All types were remarkably similar qualitatively in their daily as well as annual cycling behavior but the significance of the quantitative differences offer distinctive tradeoffs. This report presents models for water usage, depth-of-discharge, and post-cycle capacity for various levels ofmore » voltage regulation. Based on the post-cycle capacity tests, the effect of grid strength, grid thickness, and operating conditions on life expectancy are presented. A final discussion presents the results of a field deployment of solar photovoltaic-powered aids to navigation in the Miami, Florida area. Potential solutions to the battery terminal corrosion and bird guano problems observed are discussed.« less

Why undertake a pilot in a qualitative PhD study? Lessons learned to promote success.

PubMed

Wray, Jane; Archibong, Uduak; Walton, Sean

2017-01-23

Background Pilot studies can play an important role in qualitative studies. Methodological and practical issues can be shaped and refined by undertaking pilots. Personal development and researchers' competence are enhanced and lessons learned can inform the development and quality of the main study. However, pilot studies are rarely published, despite their potential to improve knowledge and understanding of the research. Aim To present the main lessons learned from undertaking a pilot in a qualitative PhD study. Discussion This paper draws together lessons learned when undertaking a pilot as part of a qualitative research project. Important methodological and practical issues identified during the pilot study are discussed including access, recruitment, data collection and the personal development of the researcher. The resulting changes to the final study are also highlighted. Conclusion Sharing experiences of and lessons learned in a pilot study enhances personal development, improves researchers' confidence and competence, and contributes to the understanding of research. Implications for practice Pilots can be used effectively in qualitative studies to refine the final design, and provide the researcher with practical experience to enhance confidence and competence.

Quasioptical devices based on extraordinary transmission at THz

NASA Astrophysics Data System (ADS)

Beruete, Miguel

2016-04-01

In this work I will present our latest advances in components developed from extraordinary transmission concepts operating at terahertz (THz) frequencies. First, a structure exhibiting two different extraordinary transmission resonances depending on the polarization of the incident wave will be shown. The peaks of transmission appear at approximately 2 and 2.5 THz for vertical and horizontal polarization, respectively, with a transmittance above 60% in both cases. Later on, a meandering line structure able to tune the extraordinary transmission resonance will be discussed. The operation frequency in this case is between 9 and 17 THz. A self-complementary polarizer will be then presented, with a high polarization purity. The fundamentals of this device based on the Babinet's principle will be discussed in depth. Finally, all these structures will be combined together to produce a dual-band Quarter Wave Plate able to convert a linear polarization at the input in a circular polarization at the output at two different bands, 1 and 2.2. THz. Some final words regarding the potential of extraordinary transmission for sensing applications will close the contribution.

The Potential of ESO for Asteroseismology

NASA Astrophysics Data System (ADS)

Aerts, Conny

2017-08-01

The research field of asteroseismology is currently undergoing its first revolution. We start with a brief history of how this field of stellar physics evolved from dream to reality, including ESO's role in it. Subsequently, we highlight how asteroseismology can serve various topics in astrophysics and focus on the current status. We discuss recent findings on the rotation and chemical mixing inside stars. Finally, we look at the perspectives of the second and third revolution in this area and highlight how ESO can play an optimal role in it.

Faster-than-light particles: A review of tachyon characteristics

NASA Astrophysics Data System (ADS)

Puscher, E. A.

1980-10-01

This report documents an analytical prediction of some of the characteristics which presently undiscovered faster-than-light sub-atomic particles (called tachyons) must possess if they are to exist without violating the Theory of Special Relativity. A brief review of necessary concepts from the Special Theory is included so that the reader might more readily understand the reasoning as it is developed. Necessary, but not all characteristics of tachyons are then identified and presented. Finally, an interesting potential relationship between tachyons and anti-gravity is discussed.

Description of the Large-Gap Magnetic Suspension System (LGMSS) ground based experiment

NASA Technical Reports Server (NTRS)

Groom, Nelson J.

1991-01-01

An overview of the Large Gap Magnetic Suspension System (LGMSS) ground-based experiment is provided. A description of the experiment, as originally defined, and the experiment objectives and potential applications of the technology resulting from the experiment are presented. Also, the results of two studies which were conducted to investigate the feasibility of implementing the experiment are presented and discussed. Finally, a description of the configuration which was selected for the experiment is described, and a summary of the paper is presented.

Use of geothermal energy for desalination in New Mexico: a feasibility study. Final report, January 1, 1977-May 30, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chaturvedi, L.; Keyes, C.G. Jr.; Swanberg, C.A.

The water requirements and availability for New Mexico are described. The possibility of using geothermal resources for desalination of the state's saline water sources is discussed. The following aspects of the problem are covered: resource evaluation, geothermal desalination technology, potential geothermal desalination sites, saline and geothermal aquifer well fields design, geothermal desalination plant waste brine disposal, process water pumping and brine disposal unit costs, environmental considerations, and legal and institutional considerations. (MHR)

Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines.

PubMed

Goyvaerts, Cleo; Breckpot, Karine

2015-01-01

In therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic research started to investigate the potential benefit of targeting these subtypes in situ. This review will discuss which antigen-presenting cell subtypes are at play and how they have been targeted and finally question the true meaning of targeting antitumor-based vaccines.

Legal implications of monitoring workers for carcinogenic and mutagenic risk.

PubMed

Damme, C J

1982-01-01

Many industries have initiated testing programs designed to identify workers who are especially vulnerable to workplace assaults by carcinogenic or mutagenic agents. This paper examines a number of legal issues attendant on such programs, including disclosure and consent, confidentiality, and other potential liability-producing factors. This paper also briefly looks at the legal issues that might arise if the federal government were to mandate similar programs. Finally, the basic rationale of industrial monitoring programs is discussed within the context of the emerging legal issues.

Isolation and confinement - Considerations for colonization

NASA Technical Reports Server (NTRS)

Akins, F. R.

1978-01-01

This paper discusses three types of isolation (sensory/perceptual, temporal, and social) that could adversely affect mankind in space. The literature dealing with laboratory and field experiments relevant to these areas is summarized and suggestions are given for dealing with these problems within the space colony community. Also, consideration is given to the potential effects of physical confinement and the need for usable space. Finally, a modification of Maslow's hierarchy of needs is proposed as a theoretical framework to understand and investigate mankind's psychological needs in space.

Advanced UXO Detection and Discrimination Using Magnetic Data Based on Extended Euler Deconvolution and Shape Identification Through Multipole Moments

DTIC Science & Technology

2011-04-01

detection. We also thank Len Pasion and Todd Meglich for helpful discussions on the Camp Sibert data set. Finally, we thank Kris Davis from Colorado...depth of potential UXO using a continuous wavelet transform: Conference proceedings, 1012– 1022, SPIE. Billings, S. D., L. R. Pasion , and D. W...1638 2009 Annual Report. Lanczos, C., 1988, Applied analysis: Courier Dover Publications. Li, Y., Krahenbuhl, R., Meglich, T., Pasion , L

An Intermolecular H-O Potential for Methyl Rotations in Solid Nitromethane

DTIC Science & Technology

1991-04-01

and Schiferl (1985). 3. DISCUSSION It is difficult to speculate on the origin of the various features (especially that at 3.5 A) of the final H-O...of nitromethane at room temperature and pressures up to 6 GPa has been investigated with single crystal X-ray diffraction (Cromer, Ryan, and Schiferl ...this purpose (Model Ill) is constructed from the coordinates in Table 3, 11 (Cromer, Ryan, and Schiferl 1985) at 3.5 GPa. The values of the internal

Study for identification of beneficial Uses of Space (BUS). Volume 2: Technical report. Book 3: Development and business analysis of space processed tungsten fox X-ray targets

NASA Technical Reports Server (NTRS)

1975-01-01

The development plans, analysis of required R and D and production resources, the costs of such resources, and finally, the potential profitability of a commercial space processing opportunity for containerless melting and resolidification of tungsten are discussed. The aim is to obtain a form of tungsten which, when fabricated into targets for X-ray tubes, provides at least, a 50 percent increase in service life.

Genetics of Post-Traumatic Stress Disorder: Informing Clinical Conceptualizations and Promoting Future Research

PubMed Central

Nugent, Nicole R.; Amstadter, Ananda B.; Koenen, Karestan C.

2009-01-01

The purpose of this article is to provide an overview of genetic research involving post-traumatic stress disorder (PTSD). First, we summarize evidence for genetic influences on PTSD from family investigations. Second, we discuss the distinct contributions to our understanding of the genetics of PTSD permitted by twin studies. Finally, we summarize findings from molecular genetic studies, which have the potential to inform our understanding of underlying biological mechanisms for the development of PTSD. PMID:18412098

Radio Frequency Interference Detection and Mitigation Techniques Using Data from Ecosar 2014 Flight Campaign

NASA Technical Reports Server (NTRS)

Osmanoglu, Batuhan; Rincon, Rafael F.; Lee, SeungKuk; Fatoyinb, Temilola; Bollian, Tobias

2016-01-01

Radio frequency interference (RFI) has strong influence on wide band airborne radar systems, especially operaingat L-band (1-2 GHz) or lower frequencies. EcoSAR is a P-band digital beamforming radar system, and RFI has tobe removed from raw echoes to obtain science quality data. In this paper we describe the current methodologyused to tackle RFI with EcoSAR, and provide an example on its performance. Finally, we discuss the advantagesand disadvantages of the method and mention potential improvements.

Cyber Technology for Materials and Structures in Aeronautics and Aerospace

NASA Technical Reports Server (NTRS)

Pipes, R. Byron

2002-01-01

The evolution of composites applications in aeronautics from 1970 to the present is discussed. The barriers and challenges to economic application and to certification are presented and recommendations for accelerated development are outlined. The potential benefits of emerging technologies to aeronautics and their foundation in composite materials are described and the resulting benefits in vehicle take off gross weight are quantified. Finally, a 21st century vision for aeronautics in which human mobility is increased by an order of magnitude is articulated.

Flight dynamics research for highly agile aircraft

NASA Technical Reports Server (NTRS)

Nguyen, Luat T.

1989-01-01

This paper highlights recent results of research conducted at the NASA Langley Research Center as part of a broad flight dynamics program aimed at developing technology that will enable future combat aircraft to achieve greatly enhanced agility capability at subsonic combat conditions. Studies of advanced control concepts encompassing both propulsive and aerodynamic approaches are reviewed. Dynamic stall phenomena and their potential impact on maneuvering performance and stability are summarized. Finally, issues of mathematical modeling of complex aerodynamics occurring during rapid, large amplitude maneuvers are discussed.

Discussing end-of-life issues with terminally ill cancer patients and their carers: a qualitative study.

PubMed

Clayton, Josephine M; Butow, Phyllis N; Arnold, Robert M; Tattersall, Martin H N

2005-08-01

Discussing end-of-life issues is of key importance to terminally ill cancer patients and their families, and a challenging topic for both health professionals and patients/carers. There is a lack of research evidence in the literature to guide clinical practice. The objective of this study was to explore the optimal content and phrasing of information when discussing the dying process and end-of-life issues with terminally ill cancer patients and their carers. We conducted focus groups and individual interviews with 19 palliative care patients and 24 carers from three palliative care services in Sydney, and 22 palliative care health professionals from around Australia. The focus groups and individual interviews were audiotaped and fully transcribed. Further focus groups and/or individual interviews were conducted until no additional topics were raised. Participants' narratives were analysed using qualitative methodology. Distinct content areas emerged for discussing end-of-life issues: treatment decisions at the end-of-life; potential future symptoms; preferences for place of death; the process of dying; what needs to be done immediately after death; and existential issues. When discussing the process of dying participants recommended: exploring the persons' fears about dying and dispelling myths; describing the final days and the likely unconscious period; and the reduced need for food and fluids. Many participants identified the dilemma regarding whether to discuss potential complications around the time of death. This paper provides strategies, words and phrases which may inform discussions about the process of dying and end-of-life issues. Further research is needed to determine the generalizability of these findings.

Examination of commercial aviation operational energy conservation strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Forty-seven fuel conservation strategies are identified for commercial aviation and the fuel saving potential, costs, constraints, and current implementation levels of these options are examined. This assessment is based on a comprehensive review of published data and discussions with representatives from industry and government. Analyses were performed to quantify the fuel saving potential of each option, and to assess the fuel savings achieved to date by the airline industry. Those options requiring further government support for option implementation were identified, rated, and ranked in accordance with a rating methodology developed in the study. Finally, recommendations are made for future governmentmore » efforts in the area of fuel conservation in commercial aviation.« less

Psilocybin--summary of knowledge and new perspectives.

PubMed

Tylš, Filip; Páleníček, Tomáš; Horáček, Jiří

2014-03-01

Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals with its history, discusses the pharmacokinetics and pharmacodynamics, and compares its action in humans and animals. It attempts to describe the mechanism of psychedelic effects and objectify its action using modern imaging and psychometric methods. Finally, it describes its therapeutic and abuse potential. Copyright © 2013 Elsevier B.V. and ECNP. All rights reserved.

Role of Host-Defence Peptides in Eye Diseases

PubMed Central

Kolar, Satya S.; McDermott, Alison M.

2013-01-01

The eye and its associated tissues including the lacrimal system and lids have evolved several defence mechanisms to prevent microbial invasion. Included among this armory are several host-defence peptides. These multifunctional molecules are being studied not only for their endogenous antimicrobial properties but also for their potential therapeutic effects. Here the current knowledge of host-defence peptide expression in the eye will be summarized. The role of these peptides in eye disease will be discussed with the primary focus being on infectious keratitis, inflammatory conditions including dry eye and wound healing. Finally the potential of using host-defence peptides and their mimetics/derivatives for the treatment and prevention of eye diseases is addressed. PMID:21584809

The Neural Underpinnings of Cognitive Flexibility and their Disruption in Psychotic Illness

PubMed Central

Waltz, James A.

2016-01-01

Schizophrenia has long been associated with a variety of cognitive deficits, including reduced cognitive flexibility. More recent findings, however, point to tremendous inter-individual variability among patients on measures of cognitive flexibility/set-shifting. With an eye toward shedding light on potential sources of variability in set-shifting abilities among schizophrenia patients, I examine the neural substrates of underlying probabilistic reversal learning (PRL) – a paradigmatic measure of cognitive flexibility – as well as neuromodulatory influences upon these systems. Finally, I report on behavioral and neuroimaging studies of PRL in schizophrenia patients, discussing the potentially influences of illness profile and antipsychotic medications on cognitive flexibility in schizophrenia. PMID:27282085

The future of fishes and fisheries in the changing oceans.

PubMed

Cheung, W W L

2018-03-01

This paper aims to highlight the risk of climate change on coupled marine human and natural systems and explore possible solutions to reduce such risk. Specifically, it explores some of the key responses of marine fish stocks and fisheries to climate change and their implications for human society. It highlights the importance of mitigating carbon emission and achieving the Paris Agreement in reducing climate risk on marine fish stocks and fisheries. Finally, it discusses potential opportunities for helping fisheries to reduce climate threats, through local adaptation. A research direction in fish biology and ecology is proposed that would help support the development of these potential solutions. © 2018 The Fisheries Society of the British Isles.

Skin appendage-derived stem cells: cell biology and potential for wound repair.

PubMed

Xie, Jiangfan; Yao, Bin; Han, Yutong; Huang, Sha; Fu, Xiaobing

2016-01-01

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review, we summarize the current knowledge of skin appendage-derived stem cells, including their fundamental characteristics, their preferentially expressed biomarkers, and their potential contribution involved in wound repair. Finally, we will also discuss current strategies, future applications, and limitations of these stem cells, attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.

Pathobiology of Anaplastic Large Cell Lymphoma

PubMed Central

Piccaluga, Pier Paolo; Gazzola, Anna; Mannu, Claudia; Agostinelli, Claudio; Bacci, Francesco; Sabattini, Elena; Sagramoso, Carlo; Piva, Roberto; Roncolato, Fernando; Inghirami, Giorgio; Pileri, Stefano A.

2010-01-01

The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated with special reference to the cytological spectrum that is indeed characteristic of the tumor. The phenotype is reported in detail: the expression of the ALK protein as well as the chromosomal abnormalities is discussed with their potential pathogenetic implications. The clinical features of ALCL are presented by underlining the difference in terms of response to therapy and survival between the ALK-positive and ALK-negative forms. Finally, the biological rationale for potential innovative targeted therapies is presented. PMID:21331150

Metagenomics and novel gene discovery

PubMed Central

Culligan, Eamonn P; Sleator, Roy D; Marchesi, Julian R; Hill, Colin

2014-01-01

Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Herein, we review both sequence-based and functional metagenomic methods to uncover novel genes and outline some of the associated problems of each type of approach, as well as potential solutions. Furthermore, we discuss the potential for metagenomic biotherapeutic discovery, with a particular focus on the human gut microbiome and finally, we outline how the discovery of novel genes may be used to create bioengineered probiotics. PMID:24317337

Finite-element solutions for geothermal systems

NASA Technical Reports Server (NTRS)

Chen, J. C.; Conel, J. E.

1977-01-01

Vector potential and scalar potential are used to formulate the governing equations for a single-component and single-phase geothermal system. By assuming an initial temperature field, the fluid velocity can be determined which, in turn, is used to calculate the convective heat transfer. The energy equation is then solved by considering convected heat as a distributed source. Using the resulting temperature to compute new source terms, the final results are obtained by iterations of the procedure. Finite-element methods are proposed for modeling of realistic geothermal systems; the advantages of such methods are discussed. The developed methodology is then applied to a sample problem. Favorable agreement is obtained by comparisons with a previous study.

The Future of Medical Dosimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Robert D., E-mail: robert_adams@med.unc.edu

2015-07-01

The world of health care delivery is becoming increasingly complex. The purpose of this manuscript is to analyze current metrics and analytically predict future practices and principles of medical dosimetry. The results indicate five potential areas precipitating change factors: a) evolutionary and revolutionary thinking processes, b) social factors, c) economic factors, d) political factors, and e) technological factors. Outcomes indicate that significant changes will occur in the job structure and content of being a practicing medical dosimetrist. Discussion indicates potential variables that can occur within each process and change factor and how the predicted outcomes can deviate from normative values.more » Finally, based on predicted outcomes, future opportunities for medical dosimetrists are given.« less

Identifying the immunomodulatory components of helminths.

PubMed

Shepherd, C; Navarro, S; Wangchuk, P; Wilson, D; Daly, N L; Loukas, A

2015-06-01

Immunomodulatory components of helminths offer great promise as an entirely new class of biologics for the treatment of inflammatory diseases. Here, we discuss the emerging themes in helminth-driven immunomodulation in the context of therapeutic drug discovery. We broadly define the approaches that are currently applied by researchers to identify these helminth molecules, highlighting key areas of potential exploitation that have been mostly neglected thus far, notably small molecules. Finally, we propose that the investigation of immunomodulatory compounds will enable the translation of current and future research efforts into potential treatments for autoimmune and allergic diseases, while at the same time yielding new insights into the molecular interface of host-parasite biology. © 2015 John Wiley & Sons Ltd.

Potential clinical impact of advanced imaging and computer-aided diagnosis in chest radiology: importance of radiologist's role and successful observer study.

PubMed

Li, Feng

2015-07-01

This review paper is based on our research experience in the past 30 years. The importance of radiologists' role is discussed in the development or evaluation of new medical images and of computer-aided detection (CAD) schemes in chest radiology. The four main topics include (1) introducing what diseases can be included in a research database for different imaging techniques or CAD systems and what imaging database can be built by radiologists, (2) understanding how radiologists' subjective judgment can be combined with technical objective features to improve CAD performance, (3) sharing our experience in the design of successful observer performance studies, and (4) finally, discussing whether the new images and CAD systems can improve radiologists' diagnostic ability in chest radiology. In conclusion, advanced imaging techniques and detection/classification of CAD systems have a potential clinical impact on improvement of radiologists' diagnostic ability, for both the detection and the differential diagnosis of various lung diseases, in chest radiology.

The development and clinical evaluation of second-generation leishmaniasis vaccines.

PubMed

Duthie, Malcolm S; Raman, Vanitha S; Piazza, Franco M; Reed, Steven G

2012-01-05

Infection with Leishmania parasites results in a range of clinical manifestations and outcomes. Control of Leishmania parasite transmission is extremely difficult due to the large number of vectors and potential reservoirs, and none of the current treatments are ideal. Vaccination could be an effective strategy to provide sustained control. In this review, the current global situation with regard to leishmaniasis, the immunology of Leishmania infection and various efforts to identify second generation vaccine candidates are briefly discussed. The variety of clinical trials conducted using the only current second generation vaccine approved for clinical use, LEISH-F1+MPL-SE, are described. Given that epidemiological evidence suggests that reducing the canine reservoir also positively impacts human incidence, efforts at providing a vaccine for leishmaniasis in dogs are highlighted. Finally, potential refinements and surrogate markers that could expedite the introduction of a vaccine that can limit the severity and incidence of leishmaniasis are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

Towards a Cancer Drug of Fungal Origin

PubMed Central

Kornienko, Alexander; Evidente, Antonio; Vurro, Maurizio; Mathieu, Véronique; Cimmino, Alessio; Evidente, Marco; van Otterlo, Willem A. L.; Dasari, Ramesh; Lefranc, Florence; Kiss, Robert

2015-01-01

Although fungi produce highly structurally diverse metabolites, many of which have served as excellent sources of pharmaceuticals, no fungi-derived agent has been approved as a cancer drug so far. This is despite a tremendous amount of research being aimed at the identification of fungal metabolites with promising anticancer activities. This review discusses the results of clinical testing of fungal metabolites and their synthetic derivatives, with the goal to evaluate how far we are from an approved cancer drug of fungal origin. Also, because in vivo studies in animal models are predictive of the efficacy and toxicity of a given compound in a clinical situation, literature describing animal cancer testing of compounds of fungal origin is reviewed as well. Agents showing the potential to advance to clinical trials are also identified. Finally, the technological challenges involved in the exploitation of fungal biodiversity and procurement of sufficient quantities of clinical candidates are discussed and potential solutions that could be pursued by researchers are highlighted. PMID:25850821

Calcium-Activated Cl- Channel: Insights on the Molecular Identity in Epithelial Tissues.

PubMed

Rottgen, Trey S; Nickerson, Andrew J; Rajendran, Vazhaikkurichi M

2018-05-10

Calcium-activated chloride secretion in epithelial tissues has been described for many years. However, the molecular identity of the channel responsible for the Ca 2+ -activated Cl − secretion in epithelial tissues has remained a mystery. More recently, TMEM16A has been identified as a new putative Ca 2+ -activated Cl − channel (CaCC). The primary goal of this article will be to review the characterization of TMEM16A, as it relates to the physical structure of the channel, as well as important residues that confer voltage and Ca 2+ -sensitivity of the channel. This review will also discuss the role of TMEM16A in epithelial physiology and potential associated-pathophysiology. This will include discussion of developed knockout models that have provided much needed insight on the functional localization of TMEM16A in several epithelial tissues. Finally, this review will examine the implications of the identification of TMEM16A as it pertains to potential novel therapies in several pathologies.

Update on mucormycosis pathogenesis

PubMed Central

Ibrahim, Ashraf S.; Kontoyiannis, Dimitrios P.

2014-01-01

Purpose of review Mucormycosis is an increasingly common fungal infection with unacceptably high mortality. The recent sequencing genome projects of Mucorales and the development of gene manipulation have enabled significant advances in understanding the pathogenesis of mucormycosis. Therefore, we review the pathogenesis of mucormycosis and highlight potential development of novel diagnostic and therapeutic modalities against this lethal disease. Recent findings Much of the work has been focused on the role of iron uptake in the virulence of Mucorales. Additionally, host receptors and fungal ligands involved in the process of tissue invasion as well as sporangiospore size and sex loci and their contribution to virulence of Mucorales are discussed. Finally, the role of innate and adaptive immunity in protection against Mucorales and new evidence about drug-induced apoptosis in these fungi are discussed. Summary Recent discoveries introduce several potentially novel diagnostic and therapeutic modalities, which are likely to improve management and outcome for mucormycosis. Future preclinical and clinical research is warranted to develop these diagnostic and therapeutic strategies. PMID:24126718

CEPC-SPPC accelerator status towards CDR

NASA Astrophysics Data System (ADS)

Gao, J.

2017-12-01

In this paper we will give an introduction to the Circular Electron Positron Collider (CEPC). The scientific background, physics goal, the collider design requirements and the conceptual design principle of the CEPC are described. On the CEPC accelerator, the optimization of parameter designs for the CEPC with different energies, machine lengths, single ring and crab-waist collision partial double ring, advanced partial double ring and fully partial double ring options, etc. have been discussed systematically, and compared. The CEPC accelerator baseline and alternative designs have been proposed based on the luminosity potential in relation with the design goals. The CEPC sub-systems, such as the collider main ring, booster, electron positron injector, etc. have also been introduced. The detector and the MAchine-Detector Interface (MDI) design have been briefly mentioned. Finally, the optimization design of the Super Proton-Proton Collider (SppC), its energy and luminosity potentials, in the same tunnel of the CEPC are also discussed. The CEPC-SppC Progress Report (2015-2016) has been published.

Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility

PubMed Central

Carta, Gaspare; Artini, Paolo Giovanni

2016-01-01

Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs) activation. PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. All PPARs isotypes are expressed along the hypothalamic-pituitary-gonadal axis and are strictly involved in reproductive functions. Since female fertility and energy metabolism are tightly interconnected, the research on female infertility points towards the exploration of potential PPARs activating/antagonizing compounds, mainly belonging to the class of thiazolidinediones (TZDs) and fibrates, as useful agents for the maintenance of metabolic homeostasis in women with ovarian dysfunctions. In the present review, we discuss the recent evidence about PPARs expression in the hypothalamic-pituitary-gonadal axis and their involvement in female reproduction. Finally, the therapeutic potential of their manipulation through several drugs is also discussed. PMID:27559343

Modified Holographic Ricci Dark Energy in Chameleon Brans-Dicke Cosmology and Its Thermodynamic Consequence

NASA Astrophysics Data System (ADS)

Jawad, A.; Chattopadhyay, S.; Bhattacharya, S.; Pasqua, A.

2015-04-01

The objective of this paper is to discuss the Chameleon Brans-Dicke gravity with non-minimally matter coupling of scalar field. We take modified Holographic Ricci dark energy model in this gravity with its energy density in interaction with energy density of cold dark matter. We assume power-law ansatz for scale factor and scalar field to discuss potential as well as coupling functions in the evolving universe. These reconstructed functions are plotted versus scalar field and time for different values of power component of scale factor n. We observe that potential and coupling functions represent increasing behavior, in particular, consistent results for a specific value of n. Finally, we have examined validity of the generalized second law of thermodynamics and we have observed its validity for all values of n. The financial Supported from Department of Science and Technology, Govt. of India under Project Grant No. SR/FTP/PS-167/2011 is thankfully acknowledged by SC

Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications.

PubMed

Leemhuis, Hans; Pijning, Tjaard; Dobruchowska, Justyna M; van Leeuwen, Sander S; Kralj, Slavko; Dijkstra, Bauke W; Dijkhuizen, Lubbert

2013-01-20

Glucansucrases are extracellular enzymes that synthesize a wide variety of α-glucan polymers and oligosaccharides, such as dextran. These carbohydrates have found numerous applications in food and health industries, and can be used as pure compounds or even be produced in situ by generally regarded as safe (GRAS) lactic acid bacteria in food applications. Research in the recent years has resulted in big steps forward in the understanding and exploitation of the biocatalytic potential of glucansucrases. This paper provides an overview of glucansucrase enzymes, their recently elucidated crystal structures, their reaction and product specificity, and the structural analysis and applications of α-glucan polymers. Furthermore, we discuss key developments in the understanding of α-glucan polymer formation based on the recently elucidated three-dimensional structures of glucansucrase proteins. Finally we discuss the (potential) applications of α-glucans produced by lactic acid bacteria in food and health related industries. Copyright © 2012 Elsevier B.V. All rights reserved.

Sickle red cell-endothelium interactions.

PubMed

Kaul, Dhananjay K; Finnegan, Eileen; Barabino, Gilda A

2009-01-01

Periodic recurrence of painful vaso-occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle red cell-endothelium interaction has been implicated as a potential initiating mechanism in vaso-occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss in vitro and microcirculatory findings on sickle red cell adhesion, its potential role in vaso-occlusion, and the current understanding of receptor-ligand interactions involved in this pathological phenomenon. In addition, we discuss the contribution of other cellular interactions (leukocytes recruitment and leukocyte-red cell interaction) to vaso-occlusion, as observed in transgenic sickle mouse models. Emphasis is given to recently discovered adhesion molecules that play a predominant role in mediating human sickle red cell adhesion. Finally, we analyze various therapeutic approaches for inhibiting sickle red cell adhesion by targeting adhesion molecules and also consider therapeutic strategies that target stimuli involved in endothelial activation and initiation of adhesion.

The therapeutic strategies against Naegleria fowleri.

PubMed

Bellini, Natália Karla; Santos, Thomás Michelena; da Silva, Marco Túlio Alves; Thiemann, Otavio Henrique

2018-04-01

Naegleria fowleri is a pathogenic amoeboflagellate most prominently known for its role as the etiological agent of the Primary Amoebic Meningoencephalitis (PAM), a disease that afflicts the central nervous system and is fatal in more than 95% of the reported cases. Although being fatal and with potential risks for an increase in the occurrence of the pathogen in populated areas, the organism receives little public health attention. A great underestimation in the number of PAM cases reported is assumed, taking into account the difficulty in obtaining an accurate diagnosis. In this review, we summarize different techniques and methods used in the identification of the protozoan in clinical and environmental samples. Since it remains unclear whether the protozoan infection can be successfully treated with the currently available drugs, we proceed to discuss the current PAM therapeutic strategies and its effectiveness. Finally, novel compounds for potential treatments are discussed as well as research on vaccine development against PAM. Copyright © 2018 Elsevier Inc. All rights reserved.

Naloxegol: A Novel Therapy in the Management of Opioid-Induced Constipation.

PubMed

Jones, Rachel; Prommer, Eric; Backstedt, David

2016-11-01

Opioid-related bowel dysfunction is a common and potentially severe adverse effect from treatment with opioid analgesics. Its development is not dose related, nor do patients develop tolerance. Opioid-induced constipation (OIC) can lead to fecal impaction, bowel obstruction, and bowel perforation as well as noncompliance with opioid analgesics and poor quality of life. Routine administration of laxatives is necessary to maintain bowel function, and, in refractory cases, other modalities must be pursued. Available options are limited but include peripherally acting μ-opioid receptor antagonists (PAMORAs), including methylnaltrexone. Naloxegol is a newly developed PAMORA that is available through the oral route. At the therapeutic dose of 25 mg daily, naloxegol is effective and safe, with a limited side effect profile and is associated with preservation of centrally mediated analgesia. In this article, we discuss the pharmacokinetics, pharmacodynamics, adverse effects, clinical trials, and cost considerations of naloxegol. Finally, we discuss its potential role as a novel key treatment for OIC in palliative medicine patients. © The Author(s) 2015.

Potential and challenges of zeolite chemistry in the catalytic conversion of biomass.

PubMed

Ennaert, Thijs; Van Aelst, Joost; Dijkmans, Jan; De Clercq, Rik; Schutyser, Wouter; Dusselier, Michiel; Verboekend, Danny; Sels, Bert F

2016-02-07

Increasing demand for sustainable chemicals and fuels has pushed academia and industry to search for alternative feedstocks replacing crude oil in traditional refineries. As a result, an immense academic attention has focused on the valorisation of biomass (components) and derived intermediates to generate valuable platform chemicals and fuels. Zeolite catalysis plays a distinct role in many of these biomass conversion routes. This contribution emphasizes the progress and potential in zeolite catalysed biomass conversions and relates these to concepts established in existing petrochemical processes. The application of zeolites, equipped with a variety of active sites, in Brønsted acid, Lewis acid, or multifunctional catalysed reactions is discussed and generalised to provide a comprehensive overview. In addition, the feedstock shift from crude oil to biomass involves new challenges in developing fields, like mesoporosity and pore interconnectivity of zeolites and stability of zeolites in liquid phase. Finally, the future challenges and perspectives of zeolites in the processing of biomass conversion are discussed.

Sleep in the Intensive Care Unit

PubMed Central

Friese, Randall S.; Gehlbach, Brian K.; Schwab, Richard J.; Weinhouse, Gerald L.; Jones, Shirley F.

2015-01-01

Sleep is an important physiologic process, and lack of sleep is associated with a host of adverse outcomes. Basic and clinical research has documented the important role circadian rhythm plays in biologic function. Critical illness is a time of extreme vulnerability for patients, and the important role sleep may play in recovery for intensive care unit (ICU) patients is just beginning to be explored. This concise clinical review focuses on the current state of research examining sleep in critical illness. We discuss sleep and circadian rhythm abnormalities that occur in ICU patients and the challenges to measuring alterations in circadian rhythm in critical illness and review methods to measure sleep in the ICU, including polysomnography, actigraphy, and questionnaires. We discuss data on the impact of potentially modifiable disruptors to patient sleep, such as noise, light, and patient care activities, and report on potential methods to improve sleep in the setting of critical illness. Finally, we review the latest literature on sleep disturbances that persist or develop after critical illness. PMID:25594808

Primordial Black Holes: Observational characteristics of the final evaporation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ukwatta, T. N.; Stump, D. R.; Linnemann, J. T.

For many early universe theories predict the creation of Primordial Black Holes (PBHs). PBHs could have masses ranging from the Planck mass to 105 solar masses or higher depending on the size of the universe at formation. A Black Hole (BH) has a Hawking temperature which is inversely proportional to its mass. Hence a sufficiently small BH will quasi-thermally radiate particles at an ever-increasing rate as emission lowers its mass and raises its temperature. Moreover, the final moments of this evaporation phase should be explosive and its description is dependent on the particle physics model. In this work we investigatemore » the final few seconds of BH evaporation, using the Standard Model and incorporating the most recent Large Hadron Collider (LHC) results, and provide a new parameterization for the instantaneous emission spectrum. We calculate for the first time energy-dependent PBH burst light curves in the GeV/TeV energy range. Moreover, we explore PBH burst search methods and potential observational PBH burst signatures. We have found a unique signature in the PBH burst light curves that may be detectable by GeV/TeV gamma-ray observatories such as the High Altitude Water Cerenkov (HAWC) observatory. Finally, the implications of beyond the Standard Model theories on the PBH burst observational characteristics are also discussed, including potential sensitivity of the instantaneous photon detection rate to a squark threshold in the 5–10 TeV range.« less

Primordial Black Holes: Observational characteristics of the final evaporation

DOE PAGES

Ukwatta, T. N.; Stump, D. R.; Linnemann, J. T.; ...

2016-07-01

For many early universe theories predict the creation of Primordial Black Holes (PBHs). PBHs could have masses ranging from the Planck mass to 105 solar masses or higher depending on the size of the universe at formation. A Black Hole (BH) has a Hawking temperature which is inversely proportional to its mass. Hence a sufficiently small BH will quasi-thermally radiate particles at an ever-increasing rate as emission lowers its mass and raises its temperature. Moreover, the final moments of this evaporation phase should be explosive and its description is dependent on the particle physics model. In this work we investigatemore » the final few seconds of BH evaporation, using the Standard Model and incorporating the most recent Large Hadron Collider (LHC) results, and provide a new parameterization for the instantaneous emission spectrum. We calculate for the first time energy-dependent PBH burst light curves in the GeV/TeV energy range. Moreover, we explore PBH burst search methods and potential observational PBH burst signatures. We have found a unique signature in the PBH burst light curves that may be detectable by GeV/TeV gamma-ray observatories such as the High Altitude Water Cerenkov (HAWC) observatory. Finally, the implications of beyond the Standard Model theories on the PBH burst observational characteristics are also discussed, including potential sensitivity of the instantaneous photon detection rate to a squark threshold in the 5–10 TeV range.« less

A Critical Review of Available Retrievable Inferior Vena Cava Filters and Future Directions

PubMed Central

Montgomery, Jennifer P.; Kaufman, John A.

2016-01-01

Inferior vena cava filters have been placed in patients for decades for protection against pulmonary embolism. The widespread use of filters has dramatically increased owing at least in part to the approval of retrievable vena cava filters. Retrievable filters have the potential to protect against pulmonary embolism and then be retrieved once no longer needed to avoid potential long-term complications. There are several retrievable vena cava filters available for use. This article discusses the different filter designs as well as the published data on these available filters. When selecting a filter for use, it is important to consider the potential short-term complications and the filters' window for retrieval. Understanding potential long-term complications is also critical, as these devices are approved for permanent placement and many filters are not retrieved. Finally, this article will address research into new designs that may be the future of vena cava filtration. PMID:27247475

A Critical Review of Available Retrievable Inferior Vena Cava Filters and Future Directions.

PubMed

Montgomery, Jennifer P; Kaufman, John A

2016-06-01

Inferior vena cava filters have been placed in patients for decades for protection against pulmonary embolism. The widespread use of filters has dramatically increased owing at least in part to the approval of retrievable vena cava filters. Retrievable filters have the potential to protect against pulmonary embolism and then be retrieved once no longer needed to avoid potential long-term complications. There are several retrievable vena cava filters available for use. This article discusses the different filter designs as well as the published data on these available filters. When selecting a filter for use, it is important to consider the potential short-term complications and the filters' window for retrieval. Understanding potential long-term complications is also critical, as these devices are approved for permanent placement and many filters are not retrieved. Finally, this article will address research into new designs that may be the future of vena cava filtration.

Basophils and allergic inflammation

PubMed Central

Siracusa, Mark C.; Kim, Brian S.; Spergel, Jonathan M.; Artis, David

2013-01-01

Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals. The relative rarity of basophils and their phenotypic similarities with mast cells resulted in this cell lineage being historically overlooked, both clinically and experimentally. However, recent studies in humans and murine systems have shown that basophils perform non-redundant effector functions and significantly contribute to the development and progression of TH2 cytokine-mediated inflammation. Although the potential functions of murine and human basophils have provoked some controversy, recent genetic approaches indicate that basophils can migrate into lymphoid tissues and, in some circumstances, cooperate with other immune cells to promote optimal TH2 cytokine responses in vivo. This article provides a brief historical perspective on basophil-related research and discusses recent studies that have identified previously unappreciated molecules and pathways that regulate basophil development, activation and function in the context of allergic inflammation. Further, we highlight the unique effector functions of basophils and discuss their contributions to the development and pathogenesis of allergic inflammation in human disease. Finally, we discuss the therapeutic potential of targeting basophils in preventing or alleviating the development and progression of allergic inflammation. PMID:24075190

Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis.

PubMed

Ye, Xiao-Dong; He, Yi; Wang, Sheng; Wong, Gordon T; Irwin, Michael G; Xia, Zhengyuan

2018-05-17

Acute myocardial infarction (AMI) is a life-threatening event. Even with timely treatment, acute ischemic myocardial injury and ensuing ischemia reperfusion injury (IRI) can still be difficult issues to tackle. Apart from radiological and other auxiliary examinations, laboratory tests of applicable cardiac biomarkers are also necessary for early diagnosis and close monitoring of this disorder. Heart-type fatty acid binding protein (H-FABP), which mainly exists inside cardiomyocytes, has recently emerged as a potentially promising biomarker for myocardial injury. In this review we discuss the sensitivity and specificity of H-FABP in the assessment of myocardial injury and IRI, especially in the early stage, and its long-term prognostic value in comparison with other commonly used cardiac biomarkers, including myoglobin (Mb), cardiac troponin I (cTnI), creatine kinase MB (CK-MB), C-reactive protein (CRP), glycogen phosphorylase isoenzyme BB (GPBB), and high-sensitivity cardiac troponin T (hs-cTnT). The potential and value of combined application of H-FABP with other biomarkers are also discussed. Finally, the prospect of H-FABP is summarized; several technical issues are discussed to facilitate wider application of H-FABP in clinical practice.

How I manage ibrutinib-refractory chronic lymphocytic leukemia

PubMed Central

2017-01-01

The introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has dramatically changed the management of chronic lymphocytic leukemia (CLL). Although responses have been durable in the majority of patients, relapses do occur, especially in the high-risk patient population. Most relapses occur as the result of acquired mutations in BTK and PLCG2, which may facilitate success with alternative targeted therapies. As outcomes after ibrutinib relapse have been reported to be poor, specific strategies are needed for this patient population. Here, I discuss the diagnosis and management of ibrutinib-refractory CLL. The focus will be on common clinical scenarios that can be mistaken for relapse and how to accurately determine which patients are relapsing. Because there is no established standard of care, I discuss currently available options for standard therapy and existing clinical data. I also discuss new agents with the potential to be effective in patients refractory to ibrutinib. Finally, I discuss strategies for long-term disease control in this patient population. PMID:28096090

Prevalence, Diagnosis and Management of Pancreatic Cystic Neoplasms: Current Status and Future Directions

PubMed Central

Farrell, James J.

2015-01-01

Cystic neoplasms of the pancreas are found with increasing prevalence, especially in elderly asymptomatic individuals. Although the overall risk of malignancy is very low, the presence of these pancreatic cysts is associated with a large degree of anxiety and further medical investigation due to concerns about malignancy. This review discusses the different cystic neoplasms of the pancreas and reports diagnostic strategies based on clinical features and imaging data. Surgical and nonsurgical management of the most common cystic neoplasms, based on the recently revised Sendai guidelines, is also discussed, with special reference to intraductal papillary mucinous neoplasm (IPMN; particularly the branch duct variant), which is the lesion most frequently identified incidentally. IPMN pathology, its risk for development into pancreatic ductal adenocarcinoma, the pros and cons of current guidelines for management, and the potential role of endoscopic ultrasound in determining cancer risk are discussed. Finally, surgical treatment, strategies for surveillance of pancreatic cysts, and possible future directions are discussed. PMID:26343068

A tale of twin Higgs: natural twin two Higgs doublet models

DOE PAGES

Yu, Jiang-Hao

2016-12-28

In original twin Higgs model, vacuum misalignment between electroweak and new physics scales is realized by adding explicit Z 2 breaking term. Introducing additional twin Higgs could accommodate spontaneous Z 2 breaking, which explains origin of this misalignment. We introduce a class of twin two Higgs doublet models with most general scalar potential, and discuss general conditions which trigger electroweak and Z 2 symmetry breaking. Various scenarios on realising the vacuum misalignment are systematically discussed in a natural composite two Higgs double model framework: explicit Z 2 breaking, radiative Z 2 breaking, tadpole-induced Z 2 breaking, and quartic-induced Z 2more » breaking. Finally, we investigate the Higgs mass spectra and Higgs phenomenology in these scenarios.« less

Wind disasters: A comprehensive review of current management strategies

PubMed Central

Marchigiani, Raffaele; Gordy, Stephanie; Cipolla, James; Adams, Raeanna C; Evans, David C; Stehly, Christy; Galwankar, Sagar; Russell, Sarah; Marco, Alan P; Kman, Nicholas; Bhoi, Sanjeev; Stawicki, Stanislaw P A; Papadimos, Thomas J

2013-01-01

Wind disasters are responsible for tremendous physical destruction, injury, loss of life and economic damage. In this review, we discuss disaster preparedness and effective medical response to wind disasters. The epidemiology of disease and injury patterns observed in the early and late phases of wind disasters are reviewed. The authors highlight the importance of advance planning and adequate preparation as well as prompt and well-organized response to potential damage involving healthcare infrastructure and the associated consequences to the medical response system. Ways to minimize both the extent of infrastructure damage and its effects on the healthcare system are discussed, focusing on lessons learned from recent major wind disasters around the globe. Finally, aspects of healthcare delivery in disaster zones are reviewed. PMID:23961458

Augmenting endogenous repair of soft tissues with nanofibre scaffolds

PubMed Central

Snelling, Sarah; Dakin, Stephanie; Carr, Andrew

2018-01-01

As our ability to engineer nanoscale materials has developed we can now influence endogenous cellular processes with increasing precision. Consequently, the use of biomaterials to induce and guide the repair and regeneration of tissues is a rapidly developing area. This review focuses on soft tissue engineering, it will discuss the types of biomaterial scaffolds available before exploring physical, chemical and biological modifications to synthetic scaffolds. We will consider how these properties, in combination, can provide a precise design process, with the potential to meet the requirements of the injured and diseased soft tissue niche. Finally, we frame our discussions within clinical trial design and the regulatory framework, the consideration of which is fundamental to the successful translation of new biomaterials. PMID:29695606

The stellar wind velocity function for red supergiants determined in eclipsing binaries

NASA Technical Reports Server (NTRS)

Ahmad, Imad A.; Stencel, Robert E.

1988-01-01

The potential for direct measurement of the acceleration of stellar winds from the supergiant component of Zeta Aurigae-type binary stars is discussed. The aberration angle of the interaction shock cone centered on the hot star provides a measure of the velocity of the cool star wind at the orbit of the secondary. This is confirmed by direct observations of stellar wind (P Cygni) line profile variations. This velocity is generally smaller than the final (terminal) velocity of the wind, deduced from the P Cygni line profiles. The contrast between these results and previously published supergiant wind models is discussed. The implication on the physics of energy source dissipation predicted in the theoretical models is considered.

The prevalence of disability among children: paradigms and estimates.

PubMed

Mudrick, Nancy R

2002-11-01

Every examination of disability among children must first grapple with definition of disability. The challenges to identifying disability among children involve not only determining the appropriate paradigm for defining disability, but also applying that paradigm to children in a meaningful way. This discussion of the prevalence of disability among children starts by examining the various paradigms utilized to identify disability and how they are interpreted when applied to children. Estimates of the prevalence of childhood disability, under different definitions of disability are presented. The goal of the discussion is to illustrate the sensitivity of the estimates of disability prevalence to the particular definition and data set used. Finally, the potential influence of the choice of paradigm on further measurement and service delivery is outlined.

Vitamin effects on the immune system: vitamins A and D take centre stage.

PubMed

Mora, J Rodrigo; Iwata, Makoto; von Andrian, Ulrich H

2008-09-01

Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.

Vaccines: From Empirical Development to Rational Design

PubMed Central

Rueckert, Christine; Guzmán, Carlos A.

2012-01-01

Infectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development. PMID:23144616

How families cope with diabetes in adolescence. An approach and case analyses.

PubMed

Hauser, S T; Paul, E L; Jacobson, A M; Weiss-Perry, B; Vieyra, M A; Rufo, P; Spetter, L D; DiPlacido, J; Wertlieb, D; Wolfsdorf, J

1988-01-01

In this paper we describe our newly constructed Family Coping Coding System. This scheme was constructed to identify family coping strategies that involve appraisal, problem solving, and emotion management dimensions. We discuss the theoretical rationale, meanings and reliability of the coping codes, and illustrate them through excerpts drawn from family discussions of a recent stressful situation (the onset of a chronic or acute illness in an adolescent member). Finally, we consider the clinical research relevance of this new assessment technique, exemplifying this potential with respect to medical compliance. We present analyses of two families with diabetic adolescents who strikingly differ with respect to compliance, and explore which family coping strategies may be predictive of an adolescent's favorable or problematic compliance to diabetes management.

The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era.

PubMed

Ritchie, Marylyn D

2012-10-01

Pharmacogenomics is emerging as a popular type of study for human genetics in recent years. This is primarily due to the many success stories and high potential for translation to clinical practice. In this review, the strengths and limitations of pharmacogenomics are discussed as well as the primary epidemiologic, clinical trial, and in vitro study designs implemented. A brief discussion of molecular and analytic approaches will be reviewed. Finally, several examples of bench-to-bedside clinical implementations of pharmacogenetic traits will be described. Pharmacogenomics continues to grow in popularity because of the important genetic associations identified that drive the possibility of precision medicine.

A Critical and Comparative Review of Fluorescent Tools for Live-Cell Imaging.

PubMed

Specht, Elizabeth A; Braselmann, Esther; Palmer, Amy E

2017-02-10

Fluorescent tools have revolutionized our ability to probe biological dynamics, particularly at the cellular level. Fluorescent sensors have been developed on several platforms, utilizing either small-molecule dyes or fluorescent proteins, to monitor proteins, RNA, DNA, small molecules, and even cellular properties, such as pH and membrane potential. We briefly summarize the impressive history of tool development for these various applications and then discuss the most recent noteworthy developments in more detail. Particular emphasis is placed on tools suitable for single-cell analysis and especially live-cell imaging applications. Finally, we discuss prominent areas of need in future fluorescent tool development-specifically, advancing our capability to analyze and integrate the plethora of high-content data generated by fluorescence imaging.

Early Literacy Instruction and Intervention

PubMed Central

Al Otaiba, Stephanie; Foorman, Barbara

2014-01-01

The purpose of this paper is to describe the efficacy of early literacy interventions and to discuss possible roles for volunteer tutors in helping prevent reading difficulties within the Response to Intervention process. First, we describe a landmark study that evaluated the impact of primary classroom instruction on reducing the proportion of students at risk for reading failure, and a more recent series of studies exploring the effects of individualizing classroom reading instruction based on students’ initial skills. Second, we review studies of more intensive early intervention to demonstrate how these interventions substantially reduce the proportion of students at risk. Third, we examine effective tutoring models that utilize volunteers. Finally, we discuss the potential role of community tutors in supporting primary classroom instruction and secondary interventions. PMID:25221452

All roads lead to PP2A: Exploiting the therapeutic potential of this phosphatase

PubMed Central

Sangodkar, Jaya; Farrington, Caroline; McClinch, Kimberly; Galsky, Matthew D.; Kastrinsky, David B.; Narla, Goutham

2015-01-01

Protein phosphatase 2A is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we will discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits, and the identification of molecular lesions and post-translational modifications leading to its dysregulation in cancer. A final section will discuss the proteins and small molecules that modulate PP2A and how these might be used to target dysregulated forms of PP2A to treat cancers and other diseases. PMID:26507691

Vitamin effects on the immune system: vitamins A and D take centre stage

PubMed Central

Mora, J. Rodrigo; Iwata, Makoto; von Andrian, Ulrich H.

2010-01-01

Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity. PMID:19172691

[Health technology assessment and its impact on pharmaceutical pricing and reimbursement policies].

PubMed

Castillo-Laborde, Carla; Silva-Illanes, Nicolás

2014-01-01

The article conceptualizes the pharmaceutical pricing and reimbursement policies related to financial coverage in the context of health systems. It introduces the pharmaceutical market as an imperfect one, in which appropriate regulation is required. Moreover, the basis that guide the pricing and reimbursement processes are defined and described in order to generate a categorization based on whether they are intended to assess the 'added value' and if the evaluation is based on cost-effectiveness criteria. This framework is used to review different types of these policies applied in the international context, discussing the role of the Health Technology Assessment in these processes. Finally, it briefly discusses the potential role of these types of policies in the Chilean context.

Self-regulation method: psychological, physiological and clinical considerations. An overview.

PubMed

Ikemi, A; Tomita, S; Kuroda, M; Hayashida, Y; Ikemi, Y

1986-01-01

Body-oriented therapies as relaxation training and certain forms of meditation are gaining popularity in the treatment and prevention of psychosomatic disorders. In this paper, a new method of self-control called self-regulation method (SRM), derived from autogenic training and Zen meditation, is presented. The technique of SRM is introduced. Secondly, physiological studies on SRM using skin temperature, galvanic skin response, and cortical evoked potentials are presented. Thirdly, the results of psychological tests conducted on SRM are presented. These psycho-physiological studies suggest that SRM may elicit a state of 'relaxed alertness'. Fourthly, clinical applications of SRM are discussed, and 3 cases are presented. Finally, SRM is discussed in relation to the psychology and physiology of 'relaxed alertness'.

Simulation and augmented reality in endovascular neurosurgery: lessons from aviation.

PubMed

Mitha, Alim P; Almekhlafi, Mohammed A; Janjua, Major Jameel J; Albuquerque, Felipe C; McDougall, Cameron G

2013-01-01

Endovascular neurosurgery is a discipline strongly dependent on imaging. Therefore, technology that improves how much useful information we can garner from a single image has the potential to dramatically assist decision making during endovascular procedures. Furthermore, education in an image-enhanced environment, especially with the incorporation of simulation, can improve the safety of the procedures and give interventionalists and trainees the opportunity to study or perform simulated procedures before the intervention, much like what is practiced in the field of aviation. Here, we examine the use of simulators in the training of fighter pilots and discuss how similar benefits can compensate for current deficiencies in endovascular training. We describe the types of simulation used for endovascular procedures, including virtual reality, and discuss the relevant data on its utility in training. Finally, the benefit of augmented reality during endovascular procedures is discussed, along with future computerized image enhancement techniques.

Extracting semantics from audio-visual content: the final frontier in multimedia retrieval.

PubMed

Naphade, M R; Huang, T S

2002-01-01

Multimedia understanding is a fast emerging interdisciplinary research area. There is tremendous potential for effective use of multimedia content through intelligent analysis. Diverse application areas are increasingly relying on multimedia understanding systems. Advances in multimedia understanding are related directly to advances in signal processing, computer vision, pattern recognition, multimedia databases, and smart sensors. We review the state-of-the-art techniques in multimedia retrieval. In particular, we discuss how multimedia retrieval can be viewed as a pattern recognition problem. We discuss how reliance on powerful pattern recognition and machine learning techniques is increasing in the field of multimedia retrieval. We review the state-of-the-art multimedia understanding systems with particular emphasis on a system for semantic video indexing centered around multijects and multinets. We discuss how semantic retrieval is centered around concepts and context and the various mechanisms for modeling concepts and context.

Synergistic neuroprotective therapies with hypothermia

PubMed Central

Cilio, Maria Roberta; Ferriero, Donna M.

2010-01-01

summary Neuroprotection is a major health care priority, given the enormous burden of human suffering and financial cost caused by perinatal brain damage. With the advent of hypothermia as therapy for term hypoxic–ischemic encephalopathy, there is hope for repair and protection of the brain after a profound neonatal insult. However, it is clear from the published clinical trials and animal studies that hypothermia alone will not provide complete protection or stimulate the repair that is necessary for normal neurodevelopmental outcome. This review critically discusses drugs used to treat seizures after hypoxia–ischemia in the neonate with attention to evidence of possible synergies for therapy. In addition, other agents such as xenon, N-acetylcysteine, erythropoietin, melatonin and cannabinoids are discussed as future potential therapeutic agents that might augment protection from hypothermia. Finally, compounds that might damage the developing brain or counteract the neuroprotective effects of hypothermia are discussed. PMID:20207600

Teaching mathematics online in the European Area of Higher Education: an instructor's point of view

NASA Astrophysics Data System (ADS)

Juan, Angel A.; Steegmann, Cristina; Huertas, Antonia; Martinez, M. Jesus; Simosa, J.

2011-03-01

This article first discusses how information technologies are changing the way knowledge is delivered at universities worldwide. Then, the article reviews some of the most popular learning management systems available today and some of the most useful online resources in the areas of Mathematics and Statistics. After that, some long-term experiences regarding the teaching of online courses in those areas at the Open University of Catalonia are discussed. Finally, the article presents the results of a large-scale survey performed in Spain that aims to reflect instructors' opinions and feelings about potential benefits and challenges of teaching mathematics online, as well as the role of emergent technologies in the context of the European Area of Higher Education. Therefore, this article contributes to the existing literature as an additional reference point, one based on our long-term experience in a large-scale online environment, for discussions involving mathematical e-learning.

The styrene-maleic acid copolymer: a versatile tool in membrane research.

PubMed

Dörr, Jonas M; Scheidelaar, Stefan; Koorengevel, Martijn C; Dominguez, Juan J; Schäfer, Marre; van Walree, Cornelis A; Killian, J Antoinette

2016-01-01

A new and promising tool in membrane research is the detergent-free solubilization of membrane proteins by styrene-maleic acid copolymers (SMAs). These amphipathic molecules are able to solubilize lipid bilayers in the form of nanodiscs that are bounded by the polymer. Thus, membrane proteins can be directly extracted from cells in a water-soluble form while conserving a patch of native membrane around them. In this review article, we briefly discuss current methods of membrane protein solubilization and stabilization. We then zoom in on SMAs, describe their physico-chemical properties, and discuss their membrane-solubilizing effect. This is followed by an overview of studies in which SMA has been used to isolate and investigate membrane proteins. Finally, potential future applications of the methodology are discussed for structural and functional studies on membrane proteins in a near-native environment and for characterizing protein-lipid and protein-protein interactions.

The Observational Status of Cosmic Inflation After Planck

NASA Astrophysics Data System (ADS)

Martin, Jérôme

The observational status of inflation after the Planck 2013 and 2015 results and the BICEP2/Keck Array and Planck joint analysis is discussed. These pedagogical lecture notes are intended to serve as a technical guide filling the gap between the theoretical articles on inflation and the experimental works on astrophysical and cosmological data. After a short discussion of the central tenets at the basis of inflation (negative self-gravitating pressure) and its experimental verifications, it reviews how the most recent Cosmic Microwave Background (CMB) anisotropy measurements constrain cosmic inflation. The fact that vanilla inflationary models are, so far, preferred by the observations is discussed and the reason why plateau-like potential versions of inflation are favored within this subclass of scenarios is explained. Finally, how well the future measurements, in particular of B-Mode CMB polarization or primordial gravity waves, will help to improve our knowledge about inflation is also investigated.

A suborbital IMU test mission

NASA Astrophysics Data System (ADS)

Lawman, Adam; Straub, Jeremy; Kerlin, Scott

2015-05-01

This paper presents work conducted in preparation for a suborbital test flight to test an inertial measurement unit's (IMU's) ability to serve as a position determination mechanism in a GPS-denied environment. Because the IMU could potentially be used at several points during flight, it is not guaranteed that a GPS fix can be used to reset the IMU after the stresses of launch. Due to this, the specific goal of this work is to characterize whether a rocket launch disrupts the IMU-based position knowledge to the extent that it is unusable. This paper discusses preparations for a sub-orbital launch mission to this end. It include a description of the hardware and software used. A discussion of the data logging mechanism and the onboard and post-flight processing which is required to compare the GPS fixes and IMU-generated positions is also presented. Finally, the utility of an IMU capable of maintaining position awareness during launch is discussed.

A case of conflicting norms? Mobilizing and accountability information in newspaper coverage of the autism-vaccine controversy.

PubMed

Clarke, Christopher E

2011-09-01

When reporting health risks, the news media are often criticized for omitting "mobilizing" information that allows readers to act on existing attitudes. Using American and British newspaper coverage of the autism-vaccine controversy as a case study, this article takes a "behind the scenes" look at normative pressures that may influence whether such information appears in coverage. In particular, can holding health officials accountable for their actions potentially "crowd out" mobilizing information? A content analysis suggests that mobilizing information (at least one of four examples) was present in only 16% of articles, compared to 38% that mentioned accountability messages (at least one of two examples). US newspapers were significantly more likely to mention at least one mobilization example. Finally, although only 11% discussed both, articles were more likely to discuss certain mobilizing and accountability examples together. Implications for journalism ethics and vaccine risk communication are discussed.

Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer.

PubMed

Wang, D; Plukker, J Th M; Coppes, R P

2017-06-01

Esophageal cancers (EC) are highly aggressive tumors, commonly presented in a locally advanced stage with a poor prognosis and survival. Up to 50% of the patients are eligible for treatment with curative intent and receive the standard treatment with neoadjuvant chemoradiotherapy (nCRT) and surgery. Currently, pathologic complete response to nCRT is 20-30%, with a partial or no response in about 50% and 20%, respectively. EC recurrences occur frequently even after successful anti-cancer treatment, suggesting high aggressiveness with increased metastatic potential. A tumor sub-population of so-called cancer stem cells (CSCs), is known to display a high metastatic potential and resistance to conventional anti-cancer therapy, hereby being responsible for the unbeneficial clinical features. In this review, a concise overview will be given of the current literature on esophageal CSCs and related metastases. Esophageal CSC markers will be discussed followed by the pathways that initiate and sustain these cells. In addition, the cellular processes, epithelial-mesenchymal transition (EMT), hypoxia and autophagy, known to contribute to cancer stemness and metastasis will be explained. Finally, potential options for treatment also related to cancer genome atlas (TCGA) data on EC will be discussed. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Facilitating the learning process: a pilot study of collaborative testing vs individualistic testing in the chiropractic college setting.

PubMed

Meseke, Jamie K; Nafziger, Rita; Meseke, Christopher A

2008-05-01

This pilot study examines the effect collaborative testing has on achievement of students taking a basic science course at a chiropractic college. The grades of 2 cohorts of students taking a basic science course were compared: the control group from the first academic term (n = 73) and the experimental group from the second academic term (n = 41). The control cohort completed weekly quizzes as individuals. The experimental cohort completed the weekly quizzes in small collaborative groups. All unit examinations and the final examination were taken by both cohorts individually. Grades for each cohort were derived from 6 weekly unit quizzes, 3 unit examinations, and a comprehensive final examination. Overall, the experimental group differed from the control group (Wilks' Lambda = 0.318; F(10,103) = 22.052; and P < .001). All quiz scores were significantly higher for the experimental group as compared with the control group. In addition, overall point totals and final course grades also differed significantly. No significant differences, however, were observed in either the first 2 unit examination scores or the final examination scores. These results confirm previous reports that student performance is enhanced by collaborative learning. Collaborative testing provided students with the opportunity to discuss their reasoning and receive immediate feedback from other group members regarding their rationale, which potentially enhanced understanding of course material. Students were encouraged to become more active in the course as group discussions emerged from individual perspectives. The collaborative learning process may enhance critical thinking abilities, which are vital for future chiropractic practitioners.

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

PubMed Central

Zhang, Xi-Feng; Liu, Zhi-Guo; Shen, Wei; Gurunathan, Sangiliyandi

2016-01-01

Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. AgNPs play an important role in nanoscience and nanotechnology, particularly in nanomedicine. Although several noble metals have been used for various purposes, AgNPs have been focused on potential applications in cancer diagnosis and therapy. In this review, we discuss the synthesis of AgNPs using physical, chemical, and biological methods. We also discuss the properties of AgNPs and methods for their characterization. More importantly, we extensively discuss the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti-cancer activity of AgNPs. In addition, we discuss therapeutic approaches and challenges for cancer therapy using AgNPs. Finally, we conclude by discussing the future perspective of AgNPs. PMID:27649147

High intensity focused ultrasound vs. cryotherapy as primary treatment for prostate cancer

PubMed Central

Ranjan, Pratyush; Saurabh, Gyan; Bansal, Rahul; Gupta, Amit

2008-01-01

Prostate cancer is one of the most commonly diagnosed cancers. Here, we will be discussing two upcoming techniques for its management. One is cryotherapy which has returned from oblivion after nearly 150 years armed with latest technology and looking as if its full potential has been recognized now. On the other hand is high intensity focused ultrasound (HIFU), the application of ultrasound to this field is relatively new and hence a lot of excitement and hope. We searched MEDLINE (PubMed 1942-2005), reference lists of retrieved articles, urology textbooks and our own data looking for studies comparing cryotherapy and HIFU. From 81 titles or abstracts, two independent reviewers identified 50 as potentially relevant. Disagreement was resolved by discussion involving the third reviewer and we finally identified 45 articles. Full reports of 45 articles were retrieved and final selection was made by the same two independent reviewers using the same criteria as for the initial selection. Data were extracted and methodological qualities of selected studies were reviewed by two independent reviewers. Qualitative analysis and synthesis were done. Treatment options depend upon the age of patient, grade of tumor and expectations out of treatment. Patient choice governs the treatment actually to be given. It is the selection of a patient for a particular treatment option that decides how favorable the outcome is going to be. Both these techniques are relatively new and they look promising but both lack long-term data to prove their efficacy. PMID:19468352

Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.

PubMed

Amores, Gerardo Ruiz; Guazzaroni, María-Eugenia; Arruda, Letícia Magalhães; Silva-Rocha, Rafael

2016-04-01

Filamentous fungi are remarkable organisms naturally specialized in deconstructing plant biomass and this feature has a tremendous potential for biofuel production from renewable sources. The past decades have been marked by a remarkable progress in the genetic engineering of fungi to generate industry-compatible strains needed for some biotech applications. In this sense, progress in this field has been marked by the utilization of high-throughput techniques to gain deep understanding of the molecular machinery controlling the physiology of these organisms, starting thus the Systems Biology era of fungi. Additionally, genetic engineering has been extensively applied to modify wellcharacterized promoters in order to construct new expression systems with enhanced performance under the conditions of interest. In this review, we discuss some aspects related to significant progress in the understating and engineering of fungi for biotechnological applications, with special focus on the construction of synthetic promoters and circuits in organisms relevant for industry. Different engineering approaches are shown, and their potential and limitations for the construction of complex synthetic circuits in these organisms are examined. Finally, we discuss the impact of engineered promoter architecture in the single-cell behavior of the system, an often-neglected relationship with a tremendous impact in the final performance of the process of interest. We expect to provide here some new directions to drive future research directed to the construction of high-performance, engineered fungal strains working as microbial cell factories.

Precambrian uranium-bearing quartz-pebble conglomerates: exploration model and United States resource potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Houston, R.S.; Karlstrom, K.E.

1979-11-01

Uranium has been discovered in fluvial quartz-pebble conglomerates in most of the Precambrian shield areas of the world, including the Canadian, African, South American, Indian, Baltic, and Australian shields. Occurrences in these and other areas are shown. Two of these occurrences, the Huronian supergroup of Canada and the Witwatersrand deposit of South Africa contain 20 to 30 percent of the planet's known uranium reserves. Thus it is critical that we understand the origin of these deposits and develop exploration models that can aid in finding new deposits. Inasmuch as these uranium-bearing conglomerates are confined almost entirely to rocks of Precambrianmore » age, Part I of this review begins with a discussion of Precambrian geology as it applies to the conglomerates. This is followed by a discussion of genetic concepts, a discussion of unresolved problems, and finally a suggested exploration model. Part II summarizes known and potential occurrences of Precambrian fossil placers in the world and evaluates them in terms of the suggested exploration model. Part III discusses the potential for important Precambrian fossil-placer uranium deposits in the United States and includes suggestions that may be helpful in establishing an exploration program in this country. Part III also brings together new (1975-1978) data on uranium occurrences in the Precambrian of the Wyoming Province. Part IV is a complete bibliography of Precambrian fossil placers, divided according to geographical areas. In total, this paper is designed to be a comprehensive review of Precambrian uranium-bearing fossil placers which will be of use to uranium explorationists and to students of Precambrian geology.« less

FINAL Progress Report DOE Grant DE-FG02-04ER15587

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mullins, Charles Buddie

Catalysis Program - Viviane Schwartz Program Manager This Final Report discusses several archival journal articles that have been published that present and discuss the results that were discovered through this DOE grant.

How does the urothelium affect bladder function in health and disease?

PubMed Central

Birder, L.A.; Ruggieri, M.; Takeda, M.; van Koeveringe, G.; Veltkamp, S.A.; Korstanje, C.; Parsons, B.A.; Fry, C.H.

2011-01-01

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery. PMID:22275289

Nanoparticles, human health hazard and regulation

PubMed Central

Seaton, Anthony; Tran, Lang; Aitken, Robert; Donaldson, Kenneth

2010-01-01

New developments in technology usually entail some hazard as well as advantage to a society. Hazard of a material translates into risk by exposure of humans and/or their environment to the agent in question, and risk is reduced by control of exposure, usually guided by regulation based on understanding of the mechanisms of harm. We illustrate risks relating to the causation of diseases associated with exposure to aerosols of combustion particles and asbestos, leading to paradigms of particle toxicity, and discuss analogies with potential exposure to manufactured nanoparticles (NPs). We review the current understanding of the hazard of NPs derived from the new science of nanotoxicology and the limited research to date into human exposure to these particles. We identify gaps in knowledge relating to the properties of NPs that might determine toxicity and in understanding the most appropriate ways both to measure this in the laboratory and to assess it in the workplace. Nevertheless, we point out that physical principles governing the behaviour of such particles allow determination of practical methods of protecting those potentially exposed. Finally, we discuss the early steps towards regulation and the difficulties facing regulators in controlling potentially harmful exposures in the absence of sufficient scientific evidence. PMID:19726441

Hybrid 3D model for the interaction of plasma thruster plumes with nearby objects

NASA Astrophysics Data System (ADS)

Cichocki, Filippo; Domínguez-Vázquez, Adrián; Merino, Mario; Ahedo, Eduardo

2017-12-01

This paper presents a hybrid particle-in-cell (PIC) fluid approach to model the interaction of a plasma plume with a spacecraft and/or any nearby object. Ions and neutrals are modeled with a PIC approach, while electrons are treated as a fluid. After a first iteration of the code, the domain is split into quasineutral and non-neutral regions, based on non-neutrality criteria, such as the relative charge density and the Debye length-to-cell size ratio. At the material boundaries of the former quasineutral region, a dedicated algorithm ensures that the Bohm condition is met. In the latter non-neutral regions, the electron density and electric potential are obtained by solving the coupled electron momentum balance and Poisson equations. Boundary conditions for both the electric current and potential are finally obtained with a plasma sheath sub-code and an equivalent circuit model. The hybrid code is validated by applying it to a typical plasma plume-spacecraft interaction scenario, and the physics and capabilities of the model are finally discussed.

Disaster Risk Education of Final Year High School Students Requires a Partnership with Families and Charity Organizations: An International Cross-sectional Survey.

PubMed

Codreanu, Tudor A; Celenza, Antonio; Ngo, Hanh

2016-06-01

Introduction The aim of disaster reduction education (DRE) is to achieve behavioral change. Over the past two decades, many efforts have been directed towards this goal, but educational activities have been developed based on unverified assumptions. Further, the literature has not identified any significant change towards disaster preparedness at the individual level. In addition, previous research suggests that change is dependent on multiple independent predictors. It is difficult to determine what specific actions DRE might result in; therefore, the preamble of such an action, which is to have discussions about it, has been chosen as the surrogate outcome measure for DRE success. This study describes the relationship of the perceived entity responsible for disaster education, disaster education per se, sex, and country-specific characteristics, with students discussing disasters with friends and family as a measure of proactive behavioral change in disaster preparedness. A total of 3,829 final year high school students participated in an international, multi-center prospective, cross-sectional study using a validated questionnaire. Nine countries with different levels of disaster exposure risk and economic development were surveyed. Regression analyses examined the relationship between the likelihood of discussing disasters with friends and family (dependent variable) and a series of independent variables. There was no statistically significant relationship between a single entity responsible for disaster education and discussions about potential hazards and risks with friends and/or family. While several independent predictors showed a significant main effect, DRE through school lessons in interaction with Family & Charity Organizations had the highest predictive value. Disaster reduction education might require different delivery channels and methods and should engage with the entities with which the teenagers are more likely to collaborate. Codreanu TA , Celenza A , Ngo H . Disaster risk education of final year high school students requires a partnership with families and charity organizations: an international cross-sectional survey. Prehosp Disaster Med. 2016;31(3):242-254.

Inflationary predictions of double-well, Coleman-Weinberg, and hilltop potentials with non-minimal coupling

NASA Astrophysics Data System (ADS)

Bostan, Nilay; Güleryüz, Ömer; Nefer Şenoğuz, Vedat

2018-05-01

We discuss how the non-minimal coupling ξphi2R between the inflaton and the Ricci scalar affects the predictions of single field inflation models where the inflaton has a non-zero vacuum expectation value (VEV) v after inflation. We show that, for inflaton values both above the VEV and below the VEV during inflation, under certain conditions the inflationary predictions become approximately the same as the predictions of the Starobinsky model. We then analyze inflation with double-well and Coleman-Weinberg potentials in detail, displaying the regions in the v-ξ plane for which the spectral index ns and the tensor-to-scalar ratio r values are compatible with the current observations. r is always larger than 0.002 in these regions. Finally, we consider the effect of ξ on small field inflation (hilltop) potentials.

Wave propagation problem for a micropolar elastic waveguide

NASA Astrophysics Data System (ADS)

Kovalev, V. A.; Murashkin, E. V.; Radayev, Y. N.

2018-04-01

A propagation problem for coupled harmonic waves of translational displacements and microrotations along the axis of a long cylindrical waveguide is discussed at present study. Microrotations modeling is carried out within the linear micropolar elasticity frameworks. The mathematical model of the linear (or even nonlinear) micropolar elasticity is also expanded to a field theory model by variational least action integral and the least action principle. The governing coupled vector differential equations of the linear micropolar elasticity are given. The translational displacements and microrotations in the harmonic coupled wave are decomposed into potential and vortex parts. Calibrating equations providing simplification of the equations for the wave potentials are proposed. The coupled differential equations are then reduced to uncoupled ones and finally to the Helmholtz wave equations. The wave equations solutions for the translational and microrotational waves potentials are obtained for a high-frequency range.

Neuroprediction, Violence, and the Law: Setting the Stage.

PubMed

Nadelhoffer, Thomas; Bibas, Stephanos; Grafton, Scott; Kiehl, Kent A; Mansfield, Andrew; Sinnott-Armstrong, Walter; Gazzaniga, Michael

2012-04-01

In this paper, our goal is to (a) survey some of the legal contexts within which violence risk assessment already plays a prominent role, (b) explore whether developments in neuroscience could potentially be used to improve our ability to predict violence, and (c) discuss whether neuropredictive models of violence create any unique legal or moral problems above and beyond the well worn problems already associated with prediction more generally. In "Violence Risk Assessment and the Law", we briefly examine the role currently played by predictions of violence in three high stakes legal contexts: capital sentencing ("Violence Risk Assessment and Capital Sentencing"), civil commitment hearings ("Violence Risk Assessment and Civil Commitment"), and "sexual predator" statutes ("Violence Risk Assessment and Sexual Predator Statutes"). In "Clinical vs. Actuarial Violence Risk Assessment", we briefly examine the distinction between traditional clinical methods of predicting violence and more recently developed actuarial methods, exemplified by the Classification of Violence Risk (COVR) software created by John Monahan and colleagues as part of the MacArthur Study of Mental Disorder and Violence [1]. In "The Neural Correlates of Psychopathy", we explore what neuroscience currently tells us about the neural correlates of violence, using the recent neuroscientific research on psychopathy as our focus. We also discuss some recent advances in both data collection ("Cutting-Edge Data Collection: Genetically Informed Neuroimaging") and data analysis ("Cutting-Edge Data Analysis: Pattern Classification") that we believe will play an important role when it comes to future neuroscientific research on violence. In "The Potential Promise of Neuroprediction", we discuss whether neuroscience could potentially be used to improve our ability to predict future violence. Finally, in "The Potential Perils of Neuroprediction", we explore some potential evidentiary ("Evidentiary Issues"), constitutional ("Constitutional Issues"), and moral ("Moral Issues") issues that may arise in the context of the neuroprediction of violence.

A Conditionally Integrable Bi-confluent Heun Potential Involving Inverse Square Root and Centrifugal Barrier Terms

NASA Astrophysics Data System (ADS)

Ishkhanyan, Tigran A.; Krainov, Vladimir P.; Ishkhanyan, Artur M.

2018-05-01

We present a conditionally integrable potential, belonging to the bi-confluent Heun class, for which the Schrödinger equation is solved in terms of the confluent hypergeometric functions. The potential involves an attractive inverse square root term x-1/2 with arbitrary strength and a repulsive centrifugal barrier core x-2 with the strength fixed to a constant. This is a potential well defined on the half-axis. Each of the fundamental solutions composing the general solution of the Schrödinger equation is written as an irreducible linear combination, with non-constant coefficients, of two confluent hypergeometric functions. We present the explicit solution in terms of the non-integer order Hermite functions of scaled and shifted argument and discuss the bound states supported by the potential. We derive the exact equation for the energy spectrum and approximate that by a highly accurate transcendental equation involving trigonometric functions. Finally, we construct an accurate approximation for the bound-state energy levels.

On Thermodiffusion and Gauge Transformations for Thermodynamic Fluxes and Driving Forces

NASA Astrophysics Data System (ADS)

Goldobin, D. S.

2017-12-01

We discuss the molecular diffusion transport in infinitely dilute liquid solutions under nonisothermal conditions. This discussion is motivated by an occurring misinterpretation of thermodynamic transport equations written in terms of chemical potential in the presence of temperature gradient. The transport equations contain the contributions owned by a gauge transformation related to the fact that chemical potential is determined up to the summand of form ( AT + B) with arbitrary constants A and B, where constant A is owned by the entropy invariance with respect to shifts by a constant value and B is owned by the potential energy invariance with respect to shifts by a constant value. The coefficients of the cross-effect terms in thermodynamic fluxes are contributed by this gauge transformation and, generally, are not the actual cross-effect physical transport coefficients. Our treatment is based on consideration of the entropy balance and suggests a promising hint for attempts of evaluation of the thermal diffusion constant from the first principles. We also discuss the impossibility of the "barodiffusion" for dilute solutions, understood in a sense of diffusion flux driven by the pressure gradient itself. When one speaks of "barodiffusion" terms in literature, these terms typically represent the drift in external potential force field (e.g., electric or gravitational fields), where in the final equations the specific force on molecules is substituted with an expression with the hydrostatic pressure gradient this external force field produces. Obviously, the interpretation of the latter as barodiffusion is fragile and may hinder the accounting for the diffusion fluxes produced by the pressure gradient itself.

Medicare and Medicaid Programs; CY 2018 Home Health Prospective Payment System Rate Update and CY 2019 Case-Mix Adjustment Methodology Refinements; Home Health Value-Based Purchasing Model; and Home Health Quality Reporting Requirements. Final rule.

PubMed

2017-11-07

This final rule updates the home health prospective payment system (HH PPS) payment rates, including the national, standardized 60-day episode payment rates, the national per-visit rates, and the non-routine medical supply (NRS) conversion factor, effective for home health episodes of care ending on or after January 1, 2018. This rule also: Updates the HH PPS case-mix weights using the most current, complete data available at the time of rulemaking; implements the third year of a 3-year phase-in of a reduction to the national, standardized 60-day episode payment to account for estimated case-mix growth unrelated to increases in patient acuity (that is, nominal case-mix growth) between calendar year (CY) 2012 and CY 2014; and discusses our efforts to monitor the potential impacts of the rebasing adjustments that were implemented in CY 2014 through CY 2017. In addition, this rule finalizes changes to the Home Health Value-Based Purchasing (HHVBP) Model and to the Home Health Quality Reporting Program (HH QRP). We are not finalizing the implementation of the Home Health Groupings Model (HHGM) in this final rule.

Prototype Engineered Barrier System Field Test (PEBSFT); Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ramirez, A.L.; Buscheck, T.; Carlson, R.

1991-08-01

This final report represents a summary of data and interpretations obtained from the Prototype Engineered Barrier System Field Test (PEBSFT) performed in G-Tunnel within the Nevada Test Site. The PEBSFT was conducted to evaluate the applicability of measurement techniques, numerical models, and procedures developed for future field tests that will be conducted in the Exploratory Studies Facilities (ESF) at Yucca Mountain. The primary objective of the test was to provide a basis for determining whether tests planned for the ESF have the potential to be successful. Chapter 1 on high frequency electromagnetic tomography discusses the rock mass electromagnetic permittivity andmore » attenuation rate changes that were measured to characterize the water distribution in the near field of a simulated waste container. The data are used to obtain quantitative estimates of how the moisture content in the rock mass changes during heating and to infer properties of the spatial variability of water distribution, leading to conclusions about the role of fractures in the system. Chapter 2 discusses the changes in rock moisture content detected by the neutron logging probe. Chapter 3 permeability tests discusses the characterization of the in-situ permeability of the fractured tuff around the borehole. The air permeability testing apparatus, the testing procedures, and the data analysis are presented. Chapter 4 describes the moisture collection system installed in the heater borehole to trap and measure the moisture volumes. Chapter 5 describes relative humidity measurements made with the thermocouple psychrometer and capacitance sensors. Chapter 6 discusses gas pressure measurements in the G-Tunnel, addressing the calibration and installation of piezoresistive-gaged transducers. Chapter 7 describes the calibration and installation of thermocouples for temperature measurements. Chapter 8 discusses the results of the PEBSFT.« less

An Analysis of Preliminary and Post-Discussion Priority Scores for Grant Applications Peer Reviewed by the Center for Scientific Review at the NIH

PubMed Central

Martin, Michael R.; Kopstein, Andrea; Janice, Joy M.

2010-01-01

There has been the impression amongst many observers that discussion of a grant application has little practical impact on the final priority scores. Rather the final score is largely dictated by the range of preliminary scores given by the assigned reviewers. The implication is that the preliminary and final scores are the same and the discussion has little impact. The purpose of this examination of the peer review process at the National Institutes of Health is to describe the relationship between preliminary priority scores of the assigned reviewers and the final priority score given by the scientific review group. This study also describes the practical importance of any differences in priority scores. Priority scores for a sample of standard (R01) research grant applications were used in this assessment. The results indicate that the preliminary meeting evaluation is positively correlated with the final meeting outcome but that they are on average significantly different. The results demonstrate that discussion at the meeting has an important practical impact on over 13% of the applications. PMID:21103331

Phytochemicals as potent modulators of autophagy for cancer therapy.

PubMed

Moosavi, Mohammad Amin; Haghi, Atousa; Rahmati, Marveh; Taniguchi, Hiroaki; Mocan, Andrei; Echeverría, Javier; Gupta, Vijai K; Tzvetkov, Nikolay T; Atanasov, Atanas G

2018-06-28

The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy. Copyright © 2018 Elsevier B.V. All rights reserved.

Serine protease inhibitors containing a Kunitz domain: their role in modulation of host inflammatory responses and parasite survival.

PubMed

de Magalhães, Mariana T Q; Mambelli, Fábio S; Santos, Bruno P O; Morais, Suellen B; Oliveira, Sergio C

2018-03-31

Proteins containing a Kunitz domain have the typical serine protease inhibition function ranging from sea anemone to man. Protease inhibitors play major roles in infection, inflammation disorders and cancer. This review discusses the role of serine proteases containing a Kunitz domain in immunomodulation induced by helminth parasites. Helminth parasites are associated with protection from inflammatory conditions. Therefore, interest has raised whether worm parasites or their products hold potential as drugs for treatment of immunological disorders. Finally, we also propose the use of recombinant SmKI-1 from Schistosoma mansoni as a potential therapeutic molecule to treat inflammatory diseases. Copyright © 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Locality-Aware CTA Clustering For Modern GPUs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Ang; Song, Shuaiwen; Liu, Weifeng

2017-04-08

In this paper, we proposed a novel clustering technique for tapping into the performance potential of a largely ignored type of locality: inter-CTA locality. We first demonstrated the capability of the existing GPU hardware to exploit such locality, both spatially and temporally, on L1 or L1/Tex unified cache. To verify the potential of this locality, we quantified its existence in a broad spectrum of applications and discussed its sources of origin. Based on these insights, we proposed the concept of CTA-Clustering and its associated software techniques. Finally, We evaluated these techniques on all modern generations of NVIDIA GPU architectures. Themore » experimental results showed that our proposed clustering techniques could significantly improve on-chip cache performance.« less

Health-beneficial nutraceuticals-myth or reality?

PubMed

Sauer, Sascha; Plauth, Annabell

2017-02-01

The modern term nutraceutical sounds extremely promising to the health-conscious consumers and to the broad audience. But what are the scientific foundations of this hybrid between nutrient and pharmaceutical? Still, most compelling evidence for potential health-beneficial effects of nutraceuticals seem to derive from descriptive and correlative epidemiological data. Here, we will take an inventory of the general concepts of research to assess the current plethora of health claims that were made for nutraceutical products. Thereby, we will discuss the limitations of current experimental approaches to advance in establishing mechanistic or causal links to the possible benefits of bioactive dietary molecules. Finally, we aim to provide perspectives to generate potential scientific evidence for the beneficial effects of nutraceuticals on human physiology.

Calibration and energy measurement of optically levitated nanoparticle sensors

NASA Astrophysics Data System (ADS)

Hebestreit, Erik; Frimmer, Martin; Reimann, René; Dellago, Christoph; Ricci, Francesco; Novotny, Lukas

2018-03-01

Optically levitated nanoparticles offer enormous potential for precision sensing. However, as for any other metrology device, the absolute measurement performance of a levitated-particle sensor is limited by the accuracy of the calibration relating the measured signal to an absolute displacement of the particle. Here, we suggest and demonstrate calibration protocols for levitated-nanoparticle sensors. Our calibration procedures include the treatment of anharmonicities in the trapping potential, as well as a protocol using a harmonic driving force, which is applicable if the sensor is coupled to a heat bath of unknown temperature. Finally, using the calibration, we determine the center-of-mass temperature of an optically levitated particle in thermal equilibrium from its motion and discuss the optimal measurement time required to determine the said temperature.

Examination of Frameworks for Safe Integration of Intelligent Small UAS into the NAS

NASA Technical Reports Server (NTRS)

Logan, Michael J.

2012-01-01

This paper discusses a proposed framework for the safe integration of small unmanned aerial systems (sUAS) into the National Airspace System (NAS). The paper briefly examines the potential uses of sUAS to build an understanding of the location and frequency of potential future flight operations based on the future applications of the sUAS systems. The paper then examines the types of systems that would be required to meet the application-level demand to determine "classes" of platforms and operations. A framework for categorization of the "intelligence" level of the UAS is postulated for purposes of NAS integration. Finally, constraints on the intelligent systems are postulated to ensure their ease of integration into the NAS.

Erectile dysfunction and coronary atherothrombosis in diabetic patients: pathophysiology, clinical features and treatment.

PubMed

Gazzaruso, Carmine

2006-03-01

The current review reports recent data available in the literature on the prevalence of erectile dysfunction and the association of erectile dysfunction with overt and silent coronary artery disease in patients with diabetes mellitus. The mechanisms by which erectile dysfunction is associated with coronary artery disease and potential clinical implications of this association have been extensively analysed. In particular, the role of endothelial dysfunction in the pathophysiology of erectile dysfunction and the potential clinical usefulness of erectile dysfunction to identify diabetic patients with silent coronary artery disease have been outlined. Finally, recent guidelines on the treatment of erectile dysfunction with phosphodiesterase-5 inhibitors in diabetic patients with and without coronary artery disease have been reported and discussed.

Cellular and molecular basis of RV hypertrophy in congenital heart disease

PubMed Central

Iacobazzi, D; Suleiman, M-S; Ghorbel, M; George, SJ; Caputo, M; Tulloh, RM

2016-01-01

RV hypertrophy (RVH) is one of the triggers of RV failure in congenital heart disease (CHD). Therefore, improving our understanding of the cellular and molecular basis of this pathology will help in developing strategic therapeutic interventions to enhance patient benefit in the future. This review describes the potential mechanisms that underlie the transition from RVH to RV failure. In particular, it addresses structural and functional remodelling that encompass contractile dysfunction, metabolic changes, shifts in gene expression and extracellular matrix remodelling. Both ischaemic stress and reactive oxygen species production are implicated in triggering these changes and will be discussed. Finally, RV remodelling in response to various CHDs as well as the potential role of biomarkers will be addressed. PMID:26516182

Amyotrophic Lateral Sclerosis: A Focus on Disease Progression

PubMed Central

Calvo, Ana C.; Manzano, Raquel; Mendonça, Deise M. F.; Muñoz, María J.; Zaragoza, Pilar

2014-01-01

Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases. However, the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives. PMID:25157374

Uncertainties of α-particle optical potential assessment around and below the Coulomb barrier

NASA Astrophysics Data System (ADS)

Avrigeanu, V.; Avrigeanu, M.; Mǎnǎilescu, C.

2017-06-01

A competition of the low-energy Coulomb excitation (CE) with the compound nucleus (CN) formation in α-induced reactions below the Coulomb barrier has recently been assumed in order to make possible the description of the latter as well as the α-particle emission by the same optical model (OM) potential. However, we show in the present work that the corresponding partial waves and integration radii provide evidence for the distinct account of the CE cross section and OM total-reaction cross section σR. Thus the largest contribution to CE cross section comes by far from partial waves larger than the ones contributing to the σR values. Finally, effects of statistical model parameters are comparatively discussed.

Effects of NN potentials on p Nuclides in the A ˜100-120 region

NASA Astrophysics Data System (ADS)

Lahiri, C.; Biswal, S. K.; Patra, S. K.

2016-02-01

Microscopic optical potentials for low-energy proton reactions have been obtained by folding density dependent M3Y (DDM3Y) interaction derived from nuclear matter calculation with densities from mean field approach to study astrophysically important proton rich nuclei in mass 100-120 region. We compare S factors for low-energy (p,γ) reactions with available experimental data and further calculate astrophysical reaction rates for (p,γ) and (p,n) reactions. Again, we choose some nonlinear R3Y (NR3Y) interactions from relativistic mean field (RMF) calculation and folded them with corresponding RMF densities to reproduce experimental S-factor values in this mass region. Finally, the effect of nonlinearity on our result is discussed.

Values and the Scientific Culture of Behavior Analysis

PubMed Central

Ruiz, Maria R; Roche, Bryan

2007-01-01

As scientists and practitioners, behavior analysts must make frequent decisions that affect many lives. Scientific principles have been our guide as we work to promote effective action across a broad spectrum of cultural practices. Yet scientific principles alone may not be sufficient to guide our decision making in cases with potentially conflicting outcomes. In such cases, values function as guides to work through ethical conflicts. We will examine two ethical systems, radical behaviorism and functional contextualism, from which to consider the role of values in behavior analysis, and discuss potential concerns. Finally, we propose philosophical pragmatism, focusing on John Dewey's notions of community and dialogue, as a tradition that can help behavior analysts to integrate talk about values and scientific practices in ethical decision making. PMID:22478484

Personalized Cancer Medicine: An Organoid Approach.

PubMed

Aboulkheyr Es, Hamidreza; Montazeri, Leila; Aref, Amir Reza; Vosough, Massoud; Baharvand, Hossein

2018-04-01

Personalized cancer therapy applies specific treatments to each patient. Using personalized tumor models with similar characteristics to the original tumors may result in more accurate predictions of drug responses in patients. Tumor organoid models have several advantages over pre-existing models, including conserving the molecular and cellular composition of the original tumor. These advantages highlight the tremendous potential of tumor organoids in personalized cancer therapy, particularly preclinical drug screening and predicting patient responses to selected treatment regimens. Here, we highlight the advantages, challenges, and translational potential of tumor organoids in personalized cancer therapy and focus on gene-drug associations, drug response prediction, and treatment selection. Finally, we discuss how microfluidic technology can contribute to immunotherapy drug screening in tumor organoids. Copyright © 2017 Elsevier Ltd. All rights reserved.

Space Shuttle/TDRSS communication and tracking systems analysis

NASA Astrophysics Data System (ADS)

Lindsey, W. C.; Chie, C. M.; Cideciyan, R.; Dessouky, K.; Su, Y. T.; Tsang, C. S.

1986-04-01

In order to evaluate the technical and operational problem areas and provide a recommendation, the enhancements to the Tracking and Data Delay Satellite System (TDRSS) and Shuttle must be evaluated through simulation and analysis. These enhancement techniques must first be characterized, then modeled mathematically, and finally updated into LinCsim (analytical simulation package). The LinCsim package can then be used as an evaluation tool. Three areas of potential enhancements were identified: shuttle payload accommodations, TDRSS SSA and KSA services, and shuttle tracking system and navigation sensors. Recommendations for each area were discussed.

New developments in reaction theory: preparing for the FRIB era

NASA Astrophysics Data System (ADS)

Nunes, F. M.; Capel, P. C.; Elster, Ch.; Hlophe, L.; Lei, Jin; Li, Weichuan; Lovell, A. E.; Potel, G.; Rotureau, J.; Poxon-Pearson, T.

2018-05-01

This is a brief report on the progress made towards an exact theory for (d,p) on heavy nuclei, which is important to determine neutron capture rates for r-process nuclei. We first discuss the role of core excitation in the framework of Faddeev equations. Following that, we provide the status of the Faddeev theory being developed in the Coulomb basis with separable interactions. We then present some recent developments on nonlocal nucleon optical potentials. Finally, the progress on the theory transfer to the continuum is summarized.

Assessing Canadian Bank Branch Operating Efficiency Using Data Envelopment Analysis

NASA Astrophysics Data System (ADS)

Yang, Zijiang

2009-10-01

In today's economy and society, performance analyses in the services industries attract more and more attention. This paper presents an evaluation of 240 branches of one big Canadian bank in Greater Toronto Area using Data Envelopment Analysis (DEA). Special emphasis was placed on how to present the DEA results to management so as to provide more guidance to them on what to manage and how to accomplish the changes. Finally the potential management uses of the DEA results were presented. All the findings are discussed in the context of the Canadian banking market.

DGAT inhibitors for obesity.

PubMed

Matsuda, Daisuke; Tomoda, Hiroshi

2007-10-01

Obesity is characterized by the accumulation of triacylglycerol in adipocytes. Diacylglycerol acyltransferase (DGAT) catalyzes the final reaction of triacylgycerol synthesis. Two isozymes of DGAT, DGAT1 and DGAT2, have been reported. Increased DGAT2 activity has a role in steatosis, while DGAT1 plays a role in very (V)LDL synthesis; increased plasma VLDL concentrations may promote obesity and thus DGAT1 is considered a potential therapeutic target of inhibition for obesity control. Several DGAT inhibitors of natural and synthetic origin have been reported, and their future prospect as anti-obesity drugs is discussed in this review.

Faster-than-light particles: a review of tachyon characteristics. Interim report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puscher, E.A.

1980-10-01

This report documents an analytical prediction of some of the characteristics which presently undiscovered faster-than-light sub-atomic particles (called tachyons) must possess if they are to exist without violating the Theory of Special Relativity. A brief review of necessary concepts from the Special Theory is included so that the reader might more readily understand the reasoning as it is developed. Necessary, but not all, characteristics of tachyons are then identified and presented. Finally, an interesting potential relationship between tachyons and anti-gravity is discussed.

Noise from turbomachinery.

NASA Technical Reports Server (NTRS)

Feiler, C. E.; Conrad, E. W.

1973-01-01

This paper reviews turbomachinery noise from turbofan engines as typified by fan noise. The mechanisms and theories of fan noise are reviewed and concepts for its reduction, including acoustic suppresion are discussed. Correlations of the overall noise data from several full-scale fans tested at NASA-Lewis Research Center are presented as indicative of the current state-of-the-art. Estimates are presented to show economics versus reduced noise for two quieted experimental engines, one with subsonic and one with supersonic fan tip speed. Finally, some concepts that may have the potential to reduce fan noise are indicated.

Space Shuttle/TDRSS communication and tracking systems analysis

NASA Technical Reports Server (NTRS)

Lindsey, W. C.; Chie, C. M.; Cideciyan, R.; Dessouky, K.; Su, Y. T.; Tsang, C. S.

1986-01-01

In order to evaluate the technical and operational problem areas and provide a recommendation, the enhancements to the Tracking and Data Delay Satellite System (TDRSS) and Shuttle must be evaluated through simulation and analysis. These enhancement techniques must first be characterized, then modeled mathematically, and finally updated into LinCsim (analytical simulation package). The LinCsim package can then be used as an evaluation tool. Three areas of potential enhancements were identified: shuttle payload accommodations, TDRSS SSA and KSA services, and shuttle tracking system and navigation sensors. Recommendations for each area were discussed.

Searching for and characterising extrasolar Earth-like planets and moons

NASA Astrophysics Data System (ADS)

Schneider, Jean

2002-10-01

The physical bases of the detection and characterisation of extrasolar Earth-like planets and moons in the reflected light and thermal emission regimes are reviewed. They both have their advantages and disadvantages, including artefacts, in the determination of planet physical parameters (mass, size, albedo, surface and atmospheric conditions etc.). After a short panorama of detection methods and the first findings, new perspectives for these different aspects are also presented. Finally brief account of the ground based programmes and space-based projects and their potentialities for Earth-like planets is made and discussed.

Wilson-loop instantons

NASA Technical Reports Server (NTRS)

Lee, Kimyeong; Holman, Richard; Kolb, Edward W.

1987-01-01

Wilson-loop symmetry breaking is considered on a space-time of the form M4 x K, where M4 is a four-dimensional space-time and K is an internal space with nontrivial and finite fundamental group. It is shown in a simple model that the different vacua obtained by breaking a non-Abelian gauge group by Wilson loops are separated in the space of gauge potentials by a finite energy barrier. An interpolating gauge configuration is then constructed between these vacua and shown to have minimum energy. Finally some implications of this construction are discussed.

Semantic e-Learning: Next Generation of e-Learning?

NASA Astrophysics Data System (ADS)

Konstantinos, Markellos; Penelope, Markellou; Giannis, Koutsonikos; Aglaia, Liopa-Tsakalidi

Semantic e-learning aspires to be the next generation of e-learning, since the understanding of learning materials and knowledge semantics allows their advanced representation, manipulation, sharing, exchange and reuse and ultimately promote efficient online experiences for users. In this context, the paper firstly explores some fundamental Semantic Web technologies and then discusses current and potential applications of these technologies in e-learning domain, namely, Semantic portals, Semantic search, personalization, recommendation systems, social software and Web 2.0 tools. Finally, it highlights future research directions and open issues of the field.

Daylighting with Fluorescent Concentrators and Highly Reflective Silver-Coated Plastic Films: A New Application for New Materials

NASA Astrophysics Data System (ADS)

Zastrow, Armin; Wittwer, Volker

1986-09-01

The interest in efficient daylighting systems has grown recently, due to their potential for saving a considerable amount of electrical energy used for lighting purposes. In this paper we discuss the properties of daylighting systems based on either fluorescent planar concentrators and transparent light guiding plates or light pipes coated with highly reflective silver coated plastic films. Finally we give first results from a demonstration project, daylighting systems in the students' living quarters in Stuttgart-Hohenheim, which is supported by the Commission of the European Communities.

CEO summit. The leadership experience--roundtable discussion.

PubMed

Corley, B; Crawford, M; Norling, R; Burgin, B; Ackerman, F K; Wallace, S

1995-02-05

All across the country, hospitals, physicians and insurers are sizing each other up as potential strategic partners. But there's much ground to be covered before a final agreement is reached, and not every decision is based on facts and figures. Sometimes it's the personal interaction between CEOs that makes the deal happen--or not. McManis Associates and Hospitals & Health Networks brought together a roundtable of CEOs to talk about the ups and downs and the ins and outs of the leadership experience. Following is a series of first-person accounts by roundtable participants.

Satellite diversity and its implications on the RAKE receiver architecture for CDMA-based S-PCN's

NASA Technical Reports Server (NTRS)

Taaghol, P.; Sammut, A.; Tafazolli, R.; Evans, B. G.

1995-01-01

In this paper we examine the applicability of RAKE receivers in a mobile LEO satellite channel and identify the potential problem areas. We then proceed to investigate the possibility of a coherent combining architecture (downlink) in the presence of satellite diversity. We closely examine the path delay difference statistics of a diversity channel and propose a delay compensation scheme for the downlink in order to reduce the complexity of the user terminal. Finally, the required modifications to the conventional RAKE receiver are proposed and discussed.

Mathematical and computational modelling of skin biophysics: a review

PubMed Central

2017-01-01

The objective of this paper is to provide a review on some aspects of the mathematical and computational modelling of skin biophysics, with special focus on constitutive theories based on nonlinear continuum mechanics from elasticity, through anelasticity, including growth, to thermoelasticity. Microstructural and phenomenological approaches combining imaging techniques are also discussed. Finally, recent research applications on skin wrinkles will be presented to highlight the potential of physics-based modelling of skin in tackling global challenges such as ageing of the population and the associated skin degradation, diseases and traumas. PMID:28804267

Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves

NASA Astrophysics Data System (ADS)

Lilienkamp, Thomas; Christoph, Jan; Parlitz, Ulrich

2017-08-01

In excitable media, chaotic dynamics governed by spiral or scroll waves is often not persistent but transient. Using extensive simulations employing different mathematical models we identify a specific type-II supertransient by an exponential increase of transient lifetimes with the system size in 2D and an investigation of the dynamics (number and lifetime of spiral waves, Kaplan-Yorke dimension). In 3D, simulations exhibit an increase of transient lifetimes and filament lengths only above a critical thickness. Finally, potential implications for understanding cardiac arrhythmias are discussed.

Mathematical and computational modelling of skin biophysics: a review

NASA Astrophysics Data System (ADS)

Limbert, Georges

2017-07-01

The objective of this paper is to provide a review on some aspects of the mathematical and computational modelling of skin biophysics, with special focus on constitutive theories based on nonlinear continuum mechanics from elasticity, through anelasticity, including growth, to thermoelasticity. Microstructural and phenomenological approaches combining imaging techniques are also discussed. Finally, recent research applications on skin wrinkles will be presented to highlight the potential of physics-based modelling of skin in tackling global challenges such as ageing of the population and the associated skin degradation, diseases and traumas.

Peripheral inflammation and cognitive aging.

PubMed

Lim, Alvin; Krajina, Katarina; Marsland, Anna L

2013-01-01

Evidence suggests that inflammation, an innate immune response facilitating recovery from injury and pathogenic invasion, is positively associated with age-related cognitive decline and may play a role in risk for dementia. Physiological pathways linking the peripheral immune and central nervous systems are outlined, and studies linking inflammation with neurocognitive function are overviewed. We also present recent studies from our laboratory showing that midlife inflammation is related to cognitive function and brain morphology. Finally, potential implications for treatment, future directions, and limitations are discussed. Copyright © 2013 S. Karger AG, Basel.

Diagnosis of multiple sclerosis through the lens of ultra-high-field MRI

NASA Astrophysics Data System (ADS)

Sati, Pascal

2018-06-01

The long-standing relationship between ultra-high-field (7 T) MRI and multiple sclerosis (MS) has brought new insights to our understanding of lesion evolution and its associated pathology. With the recent FDA approval of a commercially available scanner, 7 T MRI is finally entering the clinic with great expectations about its potential added value. By looking through the prism of MS diagnosis, this perspective article discusses current limitations and prospects of 7 T MRI techniques relevant to helping clinicians diagnose patients encountered in daily practice.

Education, leadership and partnerships: nursing potential for Universal Health Coverage

PubMed Central

Mendes, Isabel Amélia Costa; Ventura, Carla Aparecida Arena; Trevizan, Maria Auxiliadora; Marchi-Alves, Leila Maria; de Souza-Junior, Valtuir Duarte

2016-01-01

Objective: to discuss possibilities of nursing contribution for universal health coverage. Method: a qualitative study, performed by means of document analysis of the World Health Organization publications highlighting Nursing and Midwifery within universal health coverage. Results: documents published by nursing and midwifery leaders point to the need for coordinated and integrated actions in education, leadership and partnership development. Final Considerations: this article represents a call for nurses, in order to foster reflection and understanding of the relevance of their work on the consolidation of the principles of universal health coverage. PMID:26959333

Nuclear fragmentation energy and momentum transfer distributions in relativistic heavy-ion collisions

NASA Technical Reports Server (NTRS)

Khandelwal, Govind S.; Khan, Ferdous

1989-01-01

An optical model description of energy and momentum transfer in relativistic heavy-ion collisions, based upon composite particle multiple scattering theory, is presented. Transverse and longitudinal momentum transfers to the projectile are shown to arise from the real and absorptive part of the optical potential, respectively. Comparisons of fragment momentum distribution observables with experiments are made and trends outlined based on our knowledge of the underlying nucleon-nucleon interaction. Corrections to the above calculations are discussed. Finally, use of the model as a tool for estimating collision impact parameters is indicated.

Predictive monitoring of actions, EEG recordings in virtual reality.

PubMed

Ozkan, Duru G; Pezzetta, Rachele

2018-04-01

Error-related negativity (ERN) is a signal that is associated with error detection. Joch and colleagues (Joch M, Hegele M, Maurer H, Müller H, Maurer LK. J Neurophysiol 118: 486-495, 2017) successfully separated the ERN as a response to online prediction error from feedback updates. We discuss the role of ERN in action and suggest insights from virtual reality techniques; we consider the potential benefit of self-evaluation in determining the mechanisms of ERN amplitude; finally, we review the oscillatory activity that has been claimed to accompany ERN.

Potential uses of a wireless network in physical security systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witzke, Edward L.

2010-07-01

Many possible applications requiring or benefiting from a wireless network are available for bolstering physical security and awareness at high security installations or facilities. These enhancements are not always straightforward and may require careful analysis, selection, tuning, and implementation of wireless technologies. In this paper, an introduction to wireless networks and the task of enhancing physical security is first given. Next, numerous applications of a wireless network are brought forth. The technical issues that arise when using a wireless network to support these applications are then discussed. Finally, a summary is presented.

Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis.

PubMed

Ferret-Sena, Véronique; Capela, Carlos; Sena, Armando

2018-06-01

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease.

Clay-based polymer nanocomposites: research and commercial development.

PubMed

Zeng, Q H; Yu, A B; Lu, G Q; Paul, D R

2005-10-01

This paper reviews the recent research and development of clay-based polymer nanocomposites. Clay minerals, due to their unique layered structure, rich intercalation chemistry and availability at low cost, are promising nanoparticle reinforcements for polymers to manufacture low-cost, lightweight and high performance nanocomposites. We introduce briefly the structure, properties and surface modification of clay minerals, followed by the processing and characterization techniques of polymer nanocomposites. The enhanced and novel properties of such nanocomposites are then discussed, including mechanical, thermal, barrier, electrical conductivity, biodegradability among others. In addition, their available commercial and potential applications in automotive, packaging, coating and pigment, electrical materials, and in particular biomedical fields are highlighted. Finally, the challenges for the future are discussed in terms of processing, characterization and the mechanisms governing the behaviour of these advanced materials.

Bridging the research-practice gap: breaking new ground in health care.

PubMed

Mulhall, A

2001-08-01

Many theorists have discussed the existence of a gap between nursing research and practice. Consequently much time and effort has been expended in trying to devise strategies to bridge this divide. This article explores what the research-practice gap is and discusses five important reasons for it. The issue is then raised as to whether or not there is a gap between evidence and practice, despite the existence of the gap between research and practice. This is explored in relation to the potential conflict between the 'know how' knowledge important in practice and the 'know that' knowledge important in academia. Finally, the concept of practitioner-centred research is described as one strategy that would effectively obliterate the research-practice gap as it is currently conceived.

Electronic Biosensors Based on III-Nitride Semiconductors.

PubMed

Kirste, Ronny; Rohrbaugh, Nathaniel; Bryan, Isaac; Bryan, Zachary; Collazo, Ramon; Ivanisevic, Albena

2015-01-01

We review recent advances of AlGaN/GaN high-electron-mobility transistor (HEMT)-based electronic biosensors. We discuss properties and fabrication of III-nitride-based biosensors. Because of their superior biocompatibility and aqueous stability, GaN-based devices are ready to be implemented as next-generation biosensors. We review surface properties, cleaning, and passivation as well as different pathways toward functionalization, and critically analyze III-nitride-based biosensors demonstrated in the literature, including those detecting DNA, bacteria, cancer antibodies, and toxins. We also discuss the high potential of these biosensors for monitoring living cardiac, fibroblast, and nerve cells. Finally, we report on current developments of covalent chemical functionalization of III-nitride devices. Our review concludes with a short outlook on future challenges and projected implementation directions of GaN-based HEMT biosensors.

Techniques for fire detection

NASA Technical Reports Server (NTRS)

Bukowski, Richard W.

1987-01-01

An overview is given of the basis for an analysis of combustable materials and potential ignition sources in a spacecraft. First, the burning process is discussed in terms of the production of the fire signatures normally associated with detection devices. These include convected and radiated thermal energy, particulates, and gases. Second, the transport processes associated with the movement of these from the fire to the detector, along with the important phenomena which cause the level of these signatures to be reduced, are described. Third, the operating characteristics of the individual types of detectors which influence their response to signals, are presented. Finally, vulnerability analysis using predictive fire modeling techniques is discussed as a means to establish the necessary response of the detection system to provide the level of protection required in the application.

Rational treatment for multiple digit congenital absence: case report of nonvascularized toe phalangeal transfers and distraction lengthening for symbrachydactyly.

PubMed

Netscher, David T; Richards, Winston T

2006-02-01

A case is discussed in which a young male was born with symbrachydactyly of multiple digits in whom nonvascularized proximal toe phalanges were transferred to the aphalangic digits when he was an infant. This initial surgical procedure was later followed by webspace deepening and ultimately by distraction lengthening of the digits. At 8 years of age, he has a very functional hand with mobile metacarpophalangeal joints in all reconstructed fingers. In fact, he uses this reconstructed right hand as his dominant extremity. The case is discussed in context of phalangeal growth potential, specific indications for this type of reconstruction, and final long-term outcome. This case also helps to recommend rational treatment protocols for similar congenital hand anomalies.

Alaska OCS socioeconomic studies program: St. George basin and North Aleutian Shelf commercial fishing industry analysis. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tobolski, J.; Guluka, L.; Trefethen, D.

1981-10-01

This report consists of an update of the data base and analysis of the potential impacts to commercial fishing of proposed Outer Continental Shelf oil and gas lease sales in the St. George Basin and North Aleutian Shelf, situated in the Bering Sea off Alaska. Impacts on the Bristol Bay fishery are also discussed. Competition for labor between the fishing and oil industries is examined, as well as an analysis of risk of collision among vessels in the OCS areas. A description of the fisheries resources of the area is followed by an analysis of loss of access to fishingmore » grounds, and loss of or damage to gear. Impacts on the recreational fishery are also discussed.« less

Control of Maillard Reactions in Foods: Strategies and Chemical Mechanisms.

PubMed

Lund, Marianne N; Ray, Colin A

2017-06-14

Maillard reactions lead to changes in food color, organoleptic properties, protein functionality, and protein digestibility. Numerous different strategies for controlling Maillard reactions in foods have been attempted during the past decades. In this paper, recent advances in strategies for controlling the Maillard reaction and subsequent downstream reaction products in food systems are critically reviewed. The underlying mechanisms at play are presented, strengths and weaknesses of each strategy are discussed, and reasonable reaction mechanisms are proposed to reinforce the evaluations. The review includes strategies involving addition of functional ingredients, such as plant polyphenols and vitamins, as well as enzymes. The resulting trapping or modification of Maillard targets, reactive intermediates, and advanced glycation endproducts (AGEs) are presented with their potential unwanted side effects. Finally, recent advances in processing for control of Maillard reactions are discussed.

Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography.

PubMed

Gordon, Andrew Y; Jayagopal, Ashwath

2014-01-30

Optical coherence tomography has emerged as valuable imaging modalityin ophthalmology and other fields by enabling high-resolution three-dimensional imaging of tissue. In this paper, we review recent progress in the field of contrast-enhanced optical coherence tomography (OCT). We discuss exogenous and endogenous sources of OCT contrast, focusing on their use with standard OCT systems as well as emerging OCT-based imaging modalities. We include advances in the processing of OCT data that generate improved tissue contrast, including spectroscopic OCT (SOCT), as well as work utilizing secondary light sources and/or detection mechanisms to create and detect enhanced contrast, including photothermal OCT (PTOCT) and photoacoustic OCT (PAOCT). Finally, we conclude with a discussion of the translational potential of these developments as well as barriers to their clinical use.

Function-based design process for an intelligent ground vehicle vision system

NASA Astrophysics Data System (ADS)

Nagel, Robert L.; Perry, Kenneth L.; Stone, Robert B.; McAdams, Daniel A.

2010-10-01

An engineering design framework for an autonomous ground vehicle vision system is discussed. We present both the conceptual and physical design by following the design process, development and testing of an intelligent ground vehicle vision system constructed for the 2008 Intelligent Ground Vehicle Competition. During conceptual design, the requirements for the vision system are explored via functional and process analysis considering the flows into the vehicle and the transformations of those flows. The conceptual design phase concludes with a vision system design that is modular in both hardware and software and is based on a laser range finder and camera for visual perception. During physical design, prototypes are developed and tested independently, following the modular interfaces identified during conceptual design. Prototype models, once functional, are implemented into the final design. The final vision system design uses a ray-casting algorithm to process camera and laser range finder data and identify potential paths. The ray-casting algorithm is a single thread of the robot's multithreaded application. Other threads control motion, provide feedback, and process sensory data. Once integrated, both hardware and software testing are performed on the robot. We discuss the robot's performance and the lessons learned.

Giving until it hurts: prisoners are not the answer to the national organ shortage.

PubMed

Hinkle, Whitney

2002-01-01

This Note argues that prisoners, whether executed or living, should not become organ donors. The introduction acknowledges the shortage of transplantable organs in the United States and the steps that have been taken to ameliorate the crisis. Part I discusses the procurement of organs from executed prisoners, beginning with a brief examination of China, a country where this type of procurement is routinely practiced. Part I also examines organ procurement legislation pertaining to executed prisoners. Finally, Part I asserts the reasons that prisoners should not become donors, including the dead donor rule, the ban against physicians as executioners, the Oath of Hippocrates, the risk of transmissible diseases, and the negative perception that would result if organ procurement was tied to executions. Part II of this Note discusses prisoners donating their organs in return for mitigated sentences. Part II then argues that this practice should not be adopted because of the lack of informed consent and voluntary choice. Finally, Part III of this Note introduces potential solutions to the possibility of maintaining a voluntary system, moving to a presumed consent system, and using financial inducements to create a larger supply of transplantable organs.

What Does Big Data Mean for Wearable Sensor Systems?

PubMed Central

Lovell, N. H.; Yang, G. Z.; Horsch, A.; Lukowicz, P.; Murrugarra, L.; Marschollek, M.

2014-01-01

Summary Objectives The aim of this paper is to discuss how recent developments in the field of big data may potentially impact the future use of wearable sensor systems in healthcare. Methods The article draws on the scientific literature to support the opinions presented by the IMIA Wearable Sensors in Healthcare Working Group. Results The following is discussed: the potential for wearable sensors to generate big data; how complementary technologies, such as a smartphone, will augment the concept of a wearable sensor and alter the nature of the monitoring data created; how standards would enable sharing of data and advance scientific progress. Importantly, attention is drawn to statistical inference problems for which big datasets provide little assistance, or may hinder the identification of a useful solution. Finally, a discussion is presented on risks to privacy and possible negative consequences arising from intensive wearable sensor monitoring. Conclusions Wearable sensors systems have the potential to generate datasets which are currently beyond our capabilities to easily organize and interpret. In order to successfully utilize wearable sensor data to infer wellbeing, and enable proactive health management, standards and ontologies must be developed which allow for data to be shared between research groups and between commercial systems, promoting the integration of these data into health information systems. However, policy and regulation will be required to ensure that the detailed nature of wearable sensor data is not misused to invade privacies or prejudice against individuals. PMID:25123733

Chronic Rhinosinusitis and the Evolving Understanding of Microbial Ecology in Chronic Inflammatory Mucosal Disease.

PubMed

Hoggard, Michael; Wagner Mackenzie, Brett; Jain, Ravi; Taylor, Michael W; Biswas, Kristi; Douglas, Richard G

2017-01-01

Chronic rhinosinusitis (CRS) encompasses a heterogeneous group of debilitating chronic inflammatory sinonasal diseases. Despite considerable research, the etiology of CRS remains poorly understood, and debate on potential roles of microbial communities is unresolved. Modern culture-independent (molecular) techniques have vastly improved our understanding of the microbiology of the human body. Recent studies that better capture the full complexity of the microbial communities associated with CRS reintroduce the possible importance of the microbiota either as a direct driver of disease or as being potentially involved in its exacerbation. This review presents a comprehensive discussion of the current understanding of bacterial, fungal, and viral associations with CRS, with a specific focus on the transition to the new perspective offered in recent years by modern technology in microbiological research. Clinical implications of this new perspective, including the role of antimicrobials, are discussed in depth. While principally framed within the context of CRS, this discussion also provides an analogue for reframing our understanding of many similarly complex and poorly understood chronic inflammatory diseases for which roles of microbes have been suggested but specific mechanisms of disease remain unclear. Finally, further technological advancements on the horizon, and current pressing questions for CRS microbiological research, are considered. Copyright © 2016 American Society for Microbiology.

The problem of deriving the field-induced thermal emission in Poole-Frenkel theories

NASA Astrophysics Data System (ADS)

Ongaro, R.; Pillonnet, A.

1992-10-01

A discussion is made of the legitimity of implementing the usual model of field-assisted release of electrons, over the lowered potential barrier of donors. It is stressed that no reliable interpretation can avail for the usual modelling of wells, on which Poole-Frenkel (PF) derivations are established. This is so because there does not seem to exist reliable ways of implanting a Coulomb potential well in the gap of a material. In an attempt to bridge the gap between the classical potential-energy approaches and the total-energy approach of Mahapatra and Roy, a Bohr-type model of wells is proposed. In addition, a brief review of quantum treatments of electronic transport in materials is presented, in order to see if more reliable ways of approaching PF effect can be derived on undisputable bases. Finally, it is concluded that, presently, PF effect can be established safely neither theoretically nor experimentally.

Hepatic progenitor cells in canine and feline medicine: potential for regenerative strategies

PubMed Central

2014-01-01

New curative therapies for severe liver disease are urgently needed in both the human and veterinary clinic. It is important to find new treatment modalities which aim to compensate for the loss of parenchymal tissue and to repopulate the liver with healthy hepatocytes. A prime focus in regenerative medicine of the liver is the use of adult liver stem cells, or hepatic progenitor cells (HPCs), for functional recovery of liver disease. This review describes recent developments in HPC research in dog and cat and compares these findings to experimental rodent studies and human pathology. Specifically, the role of HPCs in liver regeneration, key components of the HPC niche, and HPC activation in specific types of canine and feline liver disease will be reviewed. Finally, the potential applications of HPCs in regenerative medicine of the liver are discussed and a potential role is suggested for dogs as first target species for HPC-based trials. PMID:24946932

Chemical potential and compressibility of quantum Hall bilayer excitons,.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skinner, Brian

2016-02-25

I consider a system of two parallel quantum Hall layers with total filling factor 0 or 1. When the distance between the layers is small enough, electrons and holes in opposite layers can form inter-layer excitons, which have a finite effective mass and interact via a dipole-dipole potential. I present results for the chemical potential u of the resulting bosonic system as a function of the exciton concentration n and the interlayer separation d. I show that both u and the interlayer capacitance have an unusual nonmonotonic dependence on d, owing to the interplay between an increasing dipole moment andmore » an increasing effective mass with increasing d. Finally, I discuss the transition between the superfluid and Wigner crystal phases, which is shown to occur at d x n-1/10. Results are derived first via simple intuitive arguments, and then verified with more careful analytic derivations and numeric calculations.« less

Microbicides: Topical Prevention against HIV

PubMed Central

Shattock, Robin J.; Rosenberg, Zeda

2012-01-01

Microbicides represent a potential intervention strategy for preventing HIV transmission. Vaginal microbicides would meet the need for a discreet method that women could use to protect themselves against HIV. Although early-generation microbicides failed to demonstrate efficacy, newer candidates are based on more potent antiretroviral (ARV) products. Positive data from the CAPRISA 004 trial of tenofovir gel support use in women and represent a turning point for the field. This article reviews current progress in development of ARV-based microbicides. We discuss the consensus on selection criteria, the potential for drug resistance, rationale for drug combinations, and the use of pharmacokinetic (PK)/pharmacodynamic (PD) assessment in product development. The urgent need for continued progress in development of formulations for sustained delivery is emphasized. Finally, as the boundaries between different prevention technologies become increasingly blurred, consideration is given to the potential synergy of diverse approaches across the prevention landscape. PMID:22355798

Modified screening interaction potential on dust lattice waves in dusty plasma ring

NASA Astrophysics Data System (ADS)

He, Kerong; Chen, Hui; Liu, Sanqiu

2017-05-01

In the present paper, the modified screening interaction potential was adopted to investigate the dust lattice waves in dusty ring. Firstly, the influence of parameter ε on the modified screening interaction potential was analyzed; and it was found that the parameter ε has a long-range effect on the pairwise interaction between the particles. Secondly, the dispersion relations of longitudinal and transverse waves are obtained, and the effect of long-range action parameter ε, dimensionless lattice parameter α and dimensionless shielding parameter \\tilde{κ } on the dust lattice waves propagation in dusty ring are studied. Some interesting phenomena, such as the coupling of longitudinal and transverse waves, and instabilities of transverse waves are found, which are in good agreement with some previous works. Finally, the transverse wave instabilities and the relevant critical lattice parameter αc are presented and discussed.

Genome Editing Redefines Precision Medicine in the Cardiovascular Field

PubMed Central

Lahm, Harald; Dreßen, Martina; Lange, Rüdiger; Wu, Sean M.; Krane, Markus

2018-01-01

Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies. PMID:29731778

Dark energy from the motions of neutrinos

NASA Astrophysics Data System (ADS)

Simpson, Fergus; Jimenez, Raul; Pena-Garay, Carlos; Verde, Licia

2018-06-01

Ordinarily, a scalar field may only play the role of dark energy if it possesses a potential that is either extraordinarily flat or extremely fine-tuned. Here we demonstrate that these restrictions are lifted when the scalar field undergoes persistent energy exchange with another fluid. In this scenario, the field is prevented from reversing its direction of motion, and instead may come to rest while displaced from the local minimum of its potential. Therefore almost any scalar potential is capable of initiating a prolonged phase of cosmic acceleration. If the rate of energy transfer is modulated via a derivative coupling, the field undergoes a rapid process of freezing, after which the field's equation of state mimicks that of a cosmological constant. We present a physically motivated realisation in the form of a neutrino-majoron coupling, which avoids the dynamical instabilities associated with mass-varying neutrino models. Finally we discuss possible means by which this model could be experimentally verified.

The role of radionuclide imaging in the surgical management of primary hyperparathyroidism.

PubMed

Hindié, Elif; Zanotti-Fregonara, Paolo; Tabarin, Antoine; Rubello, Domenico; Morelec, Isabelle; Wagner, Tristan; Henry, Jean-François; Taïeb, David

2015-05-01

Primary hyperparathyroidism is a frequent and potentially debilitating endocrine disorder for which surgery is the only curative treatment. The modalities of parathyroid surgery have changed over the last 2 decades, as conventional bilateral neck exploration is no longer the only surgical approach. Parathyroid scintigraphy plays a major role in defining the surgical strategy, given its ability to orient a targeted (focused) parathyroidectomy and to recognize ectopic locations or multiglandular disease. This review, which represents a collaborative effort between nuclear physicians, endocrinologists, and endocrine surgeons, emphasizes the importance of performing imaging before any surgery for primary hyperparathyroidism, even in the case of conventional bilateral neck exploration. We discuss the advantages and drawbacks of targeted parathyroidectomy and the performance of various scintigraphic protocols to guide limited surgery. We also discuss the optimal strategy to localize the offending gland before reoperation for persistent or recurrent hyperparathyroidism. Finally, we describe the potential applications of novel PET tracers, with special emphasis on (18)F-fluorocholine. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Modelling human disease with pluripotent stem cells.

PubMed

Siller, Richard; Greenhough, Sebastian; Park, In-Hyun; Sullivan, Gareth J

2013-04-01

Recent progress in the field of cellular reprogramming has opened up the doors to a new era of disease modelling, as pluripotent stem cells representing a myriad of genetic diseases can now be produced from patient tissue. These cells can be expanded and differentiated to produce a potentially limitless supply of the affected cell type, which can then be used as a tool to improve understanding of disease mechanisms and test therapeutic interventions. This process requires high levels of scrutiny and validation at every stage, but international standards for the characterisation of pluripotent cells and their progeny have yet to be established. Here we discuss the current state of the art with regard to modelling diseases affecting the ectodermal, mesodermal and endodermal lineages, focussing on studies which have demonstrated a disease phenotype in the tissue of interest. We also discuss the utility of pluripotent cell technology for the modelling of cancer and infectious disease. Finally, we spell out the technical and scientific challenges which must be addressed if the field is to deliver on its potential and produce improved patient outcomes in the clinic.

DE 1 RIMS operational characteristics

NASA Technical Reports Server (NTRS)

Olsen, R. C.; Comfort, R. H.; Chandler, M. O.; Moore, T. E.; Waite, J. H., Jr.; Reasoner, D. L.; Biddle, A. P.

1985-01-01

The Retarding Ion Mass Spectrometer (RIMS) on the Dynamics Explorer 1 spacecraft observes both the thermal and superthermal (50 eV) ions of the ionosphere and inner magnetosphere. It is capable of measuring the detailed species distribution function of these ions in many cases. It was equipped with an integral electrometer to permit in-flight calibration of the detector sensitivities and variations thereof. A guide to understanding the RIMS data set is given. The reduction process from count rates to physical quantities is discussed in some detail. The procedure used to establish in-flight calibration is described, and results of a comparison with densities from plasma wave measurements are provided. Finally, a discussion is provided of various anomalies in the data set, including changes of channeltron efficiency with time, spin modulation of the axial sensor heads, apparent potential differences between the sensor heads, and failures of the radial head retarding potential sweep and of the -Z axial head aperture plane bias. Studies of the RIMS data set should be conducted only with a thorough awareness of the material presented here, or in collaboration with one of the scientists actively involved with RIMS data analysis.

Myelination and mTOR

PubMed Central

Figlia, Gianluca; Gerber, Daniel

2017-01-01

Abstract Myelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination. Here, we will discuss metabolic aspects of myelination, illustrate the main metabolic processes regulated by mTORC1, and review advances on the role of mTORC1 in myelination of the central nervous system and the peripheral nervous system. Recent progress has revealed a complex role of mTORC1 in myelinating cells that includes, besides positive regulation of myelin growth, additional critical functions in the stages preceding active myelination. Based on the available evidence, we will also highlight potential nonoverlapping roles between mTORC1 and its known main upstream pathways PI3K‐Akt, Mek‐Erk1/2, and AMPK in myelinating cells. Finally, we will discuss signals that are already known or hypothesized to be responsible for the regulation of mTORC1 activity in myelinating cells. PMID:29210103

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

PubMed Central

Bavarsad Shahripour, Reza; Harrigan, Mark R; Alexandrov, Andrei V

2014-01-01

Background There is an expanding field of research investigating the benefits of medicines with multiple mechanisms of action across neurological disorders. N-acetylcysteine (NAC), widely known as an antidote to acetaminophen overdose, is now emerging as treatment of vascular and nonvascular neurological disorders. NAC as a precursor to the antioxidant glutathione modulates glutamatergic, neurotrophic, and inflammatory pathways. Aim and discussion Most NAC studies up to date have been carried out in animal models of various neurological disorders with only a few studies completed in humans. In psychiatry, NAC has been tested in over 20 clinical trials as an adjunctive treatment; however, this topic is beyond the scope of this review. Herein, we discuss NAC molecular, intracellular, and systemic effects, focusing on its potential applications in neurodegenerative diseases including spinocerebellar ataxia, Parkinson's disease, tardive dyskinesia, myoclonus epilepsy of the Unverricht–Lundbor type as well as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. Conclusion Finally, we review the potential applications of NAC to facilitate recovery after traumatic brain injury, cerebral ischemia, and in treatment of cerebrovascular vasospasm after subarachnoid hemorrhage. PMID:24683506

Potential phytocompounds for developing breast cancer therapeutics: Nature's healing touch.

PubMed

Iqbal, Javed; Abbasi, Banzeer Ahsan; Batool, Riffat; Mahmood, Tariq; Ali, Barkat; Khalil, Ali Talha; Kanwal, Sobia; Shah, Sayed Afzal; Ahmad, Riaz

2018-05-15

Breast cancer (BC) is a devastating disease in female around the world causing significant health care burden in both developed and developing countries. In many cases BC has shown resistance to chemotherapy, radiation and hormonal therapy. Development of new, cost effective, affordable treatment method is the need of hour. Chemical compounds isolated from plants are often biologically active and is attracting the attention of scientific community. Different in vitro and in vivo studies have shown a potential role in reducing the risk of cancer metastasis. Large number of phytochemicals are considered to regulate several molecular and metabolic processes like cell cycle regulation, apoptosis activation, angiogenesis and metastatic suppression that can hinders cancer progression. An extensive review of literature has been conducted to underline the key phytochemicals and their mechanism of action. This review article has discussed in detail the regulatory roles of phytochemicals, their analogs and nanoformulations and the probability of using phytochemicals in therapeutic management of BC. Finally, current limitations, challenges and future perspectives of these phytochemicals are also critically discussed. Copyright © 2018 Elsevier B.V. All rights reserved.

New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future.

PubMed

Taylor, Melissa; Rössler, Jochen; Geoerger, Birgit; Vassal, Gilles; Farace, Françoise

2010-07-01

Antiangiogenic strategies are affording considerable interest and have become a major milestone in therapeutics of various adult cancers. However, progress has been slow to expand such therapies to patients with pediatric solid malignancies. This review discusses the principal pathways for angiogenesis in pediatric solid malignancies and summarizes recent preclinical and clinical data on antiangiogenesis strategies in these tumors. The reader will gain state-of-the-art knowledge in the current advancements of antiangiogenic therapies in pediatric clinical trials in regard to supporting preclinical data, and in the status of potential biomarkers investigated for monitoring angiogenesis inhibitors. Mechanisms of resistance to antiangiogenic therapy will also be discussed. Finally, we describe our experience in the monitoring of circulating endothelial cells and progenitors and their potential role as biomarkers of metastatic disease and resistance to antiangiogenic therapies. Evaluation and development of antiangiogenesis protocols are starting and represent a crucial step in the management of pediatric solid malignancies today. Emphasis should be placed on the development of proper surrogate markers to monitor antiangiogenic activity and on the possible long-term effects of these therapies in a pediatric population.

Environmental health impact in the hospital laundry.

PubMed

Byrns, G E; Bland, L A

1980-01-01

The task of surveying the hospital laundry is often dismissed by public health officials as unnecessary because the laundry cycle is generally considered to be capable of destroying all pathogens. Even though a properly operated laundry can produce a relatively bacteria free product, there are a number of variables that have an impact on the bacterial quality of the linen before it reaches the patient. It is vital that surveillance personnel understand these factors during processing, transporting, or sorting linen so that the final product is aesthetically, chemically, and bacteriologically acceptable for patient use. At the U. S. Public Health Service Hospital laundry in New Orleans, surveillance by the Environmental Health Department has identified potential problem areas. Operational improvements have been instituted at this laundry that would not have been possible without a thorough understanding of the laundry cycle. The authors describe the laundry cycle, including potential problem areas; identify useful microbial and chemical surveillance methods; and discuss process control procedures. This information will help the environmental health worker in discussions with laundry personnel regarding contamination control and operational efficiency.

Vapor-liquid nucleation: the solid touch.

PubMed

Yarom, Michal; Marmur, Abraham

2015-08-01

Vapor-liquid nucleation is a ubiquitous process that has been widely researched in many disciplines. Yet, case studies are quite scattered in the literature, and the implications of some of its basic concepts are not always clearly stated. This is especially noticeable for heterogeneous nucleation, which involves a solid surface in touch with the liquid and vapor. The current review attempts to offer a comprehensive, though concise, thermodynamic discussion of homogeneous and heterogeneous nucleation in vapor-liquid systems. The fundamental concepts of nucleation are detailed, with emphasis on the role of the chemical potential, and on intuitive explanations whenever possible. We review various types of nucleating systems and discuss the effect of the solid geometry on the characteristics of the new phase formation. In addition, we consider the effect of mixing on the vapor-liquid equilibrium. An interesting sub-case is that of a non-volatile solute that modifies the chemical potential of the liquid, but not of the vapor. Finally, we point out topics that need either further research or more exact, accurate presentation. Copyright © 2014 Elsevier B.V. All rights reserved.

Evolved Stars, Masers And Polarization Submm/mm/cm QUESO Workshop 2017 (QUESO2017), Centimetre-Sub-Millimetre Q&U (and V) European Southern Observatory Workshop, held 25-27 October, 2017 at ESO, Garching bei München, Germany. Online at https://www.eso.org/sci/meetings/2017/QUESO2017.html, id.35

NASA Astrophysics Data System (ADS)

Humphreys, Elizabeth

2017-11-01

Cool evolved stars on the Asymptotic Giant Branch (AGB) and Red Supergiants (RSG) often host strong masers, for example from SiO, water and OH. The maser emission can display high degrees of circular and linear polarization, potentially revealing information on magnetic field strength and morphology at different radii in the circumstellar envelopes. In this review, I will describe maser polarization theory and discuss was has been learnt so far from maser observations. I will also discuss dust polarization at (sub)mm wavelengths and the role that full polarization observations using ALMA is going to play in better characterizing evolved stars. Finally, I will talk about the potential impact of magnetic fields in the evolution of the stars, for example the shaping of AGB stars to often highly axisymmetric/aspherical Planetary Nebulae.queso2017queso2017

Advanced Sensors and Controls for Building Applications: Market Assessment and Potential R&D Pathways

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brambley, Michael R.; Haves, Philip; McDonald, Sean C.

2005-04-13

Significant energy savings can be achieved in commercial building operation, along with increased comfort and control for occupants, through the implementation of advanced technologies. This document provides a market assessment of existing building sensors and controls and presents a range of technology pathways (R&D options) for pursuing advanced sensors and building control strategies. This paper is actually a synthesis of five other white papers: the first describes the market assessment including estimates of market potential and energy savings for sensors and control strategies currently on the market as well as a discussion of market barriers to these technologies. The othermore » four cover technology pathways: (1) current applications and strategies for new applications, (2) sensors and controls, (3) networking, security, and protocols and standards, and (4) automated diagnostics, performance monitoring, commissioning, optimal control and tools. Each technology pathway chapter gives an overview of the technology or application. This is followed by a discussion of needs and the current status of the technology. Finally, a series of research topics is proposed.« less

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism.

PubMed

Kalyanaraman, Balaraman

2017-08-01

This review of the basics of cancer metabolism focuses on exploiting the metabolic differences between normal and cancer cells. The first part of the review covers the different metabolic pathways utilized in normal cells to generate cellular energy, or ATP, and the glycolytic intermediates required to build the cellular machinery. The second part of the review discusses aerobic glycolysis, or the Warburg effect, and the metabolic reprogramming involving glycolysis, tricarboxylic acid cycle, and glutaminolysis in the context of developing targeted inhibitors in cancer cells. Finally, the selective targeting of cancer mitochondrial metabolism using positively charged lipophilic compounds as potential therapeutics and their ability to mitigate the toxic side effects of conventional chemotherapeutics in normal cells are discussed. I hope this graphical review will be useful in helping undergraduate, graduate, and medical students understand how investigating the basics of cancer cell metabolism could provide new insight in developing potentially new anticancer treatment strategies. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

An equity tool for health impact assessments: Reflections from Mongolia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snyder, Jeremy, E-mail: jeremycsnyder@sfu.ca; Wagler, Meghan, E-mail: meghanwagler@gmail.com; Lkhagvasuren, Oyun, E-mail: l_oyun2002@yahoo.com

2012-04-15

A health impact assessment (HIA) is a tool for assessing the potential effects of a project or policy on a population's health. In this paper, we discuss a tool for successfully integrating equity concerns into HIAs. This discussion is the product of collaboration by Mongolian and Canadian experts, and it incorporates comments and suggestions of participants of a workshop on equity focused HIAs that took place in Mongolia in October, 2010. Our motivation for discussing this tool is based on the observation that existing HIAs tend either to fail to define equity or use problematic accounts of this concept. Inmore » this paper we give an overview of socio-demographic and health indicators in Mongolia and briefly discuss its mining industry. We then review three accounts of equity and argue for the importance of developing a consensus understanding of this concept when integrating considerations of equity into an HIA. Finally, we present findings from the workshop in Mongolia and outline a tool, derived from lessons from this workshop, for critically considering and integrating the concept of equity into an HIA.« less

Smart Crack Control in Concrete through Use of Phase Change Materials (PCMs): A Review

PubMed Central

2018-01-01

Cracks in concrete structures present a threat to their durability. Therefore, numerous research studies have been devoted to reducing concrete cracking. In recent years, a new approach has been proposed for controlling temperature related cracking—utilization of phase change materials (PCMs) in concrete. Through their ability to capture heat, PCMs can offset temperature changes and reduce gradients in concrete structures. Nevertheless, they can also influence concrete properties. This paper presents a comprehensive overview of the literature devoted to using PCMs to control temperature related cracking in concrete. First, types of PCMs and ways of incorporation in concrete are discussed. Then, possible uses of PCMs in concrete technology are discussed. Further, the influences of PCMs on concrete properties (fresh, hardened, durability) are discussed in detail. This is followed by a discussion of modelling techniques for PCM-concrete composites and their performance. Finally, a summary and the possible research directions for future work are given. This overview aims to assure the researchers and asset owners of the potential of this maturing technology and bring it one step closer to practical application. PMID:29695076

Smart Crack Control in Concrete through Use of Phase Change Materials (PCMs): A Review.

PubMed

Šavija, Branko

2018-04-24

Cracks in concrete structures present a threat to their durability. Therefore, numerous research studies have been devoted to reducing concrete cracking. In recent years, a new approach has been proposed for controlling temperature related cracking—utilization of phase change materials (PCMs) in concrete. Through their ability to capture heat, PCMs can offset temperature changes and reduce gradients in concrete structures. Nevertheless, they can also influence concrete properties. This paper presents a comprehensive overview of the literature devoted to using PCMs to control temperature related cracking in concrete. First, types of PCMs and ways of incorporation in concrete are discussed. Then, possible uses of PCMs in concrete technology are discussed. Further, the influences of PCMs on concrete properties (fresh, hardened, durability) are discussed in detail. This is followed by a discussion of modelling techniques for PCM-concrete composites and their performance. Finally, a summary and the possible research directions for future work are given. This overview aims to assure the researchers and asset owners of the potential of this maturing technology and bring it one step closer to practical application.

Chemical diversity of microbial volatiles and their potential for plant growth and productivity

PubMed Central

Kanchiswamy, Chidananda Nagamangala; Malnoy, Mickael; Maffei, Massimo E.

2015-01-01

Microbial volatile organic compounds (MVOCs) are produced by a wide array of microorganisms ranging from bacteria to fungi. A growing body of evidence indicates that MVOCs are ecofriendly and can be exploited as a cost-effective sustainable strategy for use in agricultural practice as agents that enhance plant growth, productivity, and disease resistance. As naturally occurring chemicals, MVOCs have potential as possible alternatives to harmful pesticides, fungicides, and bactericides as well as genetic modification. Recent studies performed under open field conditions demonstrate that efficiently adopting MVOCs may contribute to sustainable crop protection and production. We review here the chemical diversity of MVOCs by describing microbial–plants and microbial–microbial interactions. Furthermore, we discuss MVOCs role in inducing phenotypic plant responses and their potential physiological effects on crops. Finally, we analyze potential and actual limitations for MVOC use and deployment in field conditions as a sustainable strategy for improving productivity and reducing pesticide use. PMID:25821453

Factors Associated with Discussion of Disasters by Final Year High School Students: An International Cross-sectional Survey.

PubMed

Codreanu, Tudor A; Celenza, Antonio; Alabdulkarim, Ali A Rahman

2015-08-01

Introduction The effect on behavioral change of educational programs developed to reduce the community's disaster informational vulnerability is not known. This study describes the relationship of disaster education, age, sex, and country-specific characteristics with students discussing disasters with friends and family, a measure of proactive behavioral change in disaster preparedness. Three thousand eight hundred twenty-nine final year high school students were enrolled in an international, multi-center prospective, cross-sectional study using a pre-validated written questionnaire. In order to obtain information from different educational systems, from countries with different risk of exposure to disasters, and from countries with varied economic development status, students from Bahrain, Croatia, Cyprus, Egypt, Greece, Italy, Portugal, Romania, and Timor-Leste were surveyed. Logistic regression analyses examined the relationship between the likelihood of discussing disasters with friends and family (dependent variable) and a series of independent variables (age, gender, participation in school lessons about disasters, existence of a national disaster educational program, ability to list pertinent example of disasters, country's economic group, and disaster risk index) captured by the questionnaire or available as published data. There was no statistically significant relationship between age, awareness of one's surroundings, planning for the future, and foreseeing consequences of events with discussions about potential hazards and risks with friends and/or family. The national educational budget did not have a statistically significant influence. Participants who lived in a low disaster risk and high income Organization for Economic Co-operation and Development (OECD) country were more likely to discuss disasters. While either school lessons or a national disaster education program had a unique, significant contribution to the model, neither had a better predictive utility. The predictors (national disaster program, school lessons, gender, ability to list examples of disasters, country's disaster risk index, and level of economic development), although significant, were not sufficient in predicting disaster discussions amongst teenagers.

Cytoprotective mechanism of action of curcumin against cataract.

PubMed

Raman, Thiagarajan; Ramar, Manikandan; Arumugam, Munusamy; Nabavi, Seyed Mohammad; Varsha, Mosur Kumaraswamy Nagarajan Sai

2016-06-01

This review discusses the relationship between oxidative stress and cataract formation, molecular mechanism of curcumin action and potential benefits of treatment with the antioxidant curcumin. The first section deals with curcumin and endogenous antioxidants. The second section focuses on the action of curcumin on lipid peroxidation. Calcium homeostasis and curcumin will be discussed in the third section. The fourth section discusses the role of crystallin proteins that are responsible for maintaining lens transparency and the role of curcumin in regulating crystallin expression. The interaction of curcumin with transcription factors will be dealt in the fifth section. The final section will focus on the effect of curcumin on aldose reductase, which is associated with hyperglycemia and cataract. One of the strongest antioxidants is curcumin which has been shown to be very effective against cataract. This compound is better than other antioxidants in preventing cataract but its limited bioavailability can be addressed by employing nanotechnology. Copyright © 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Importance of perspective in economic analyses of cancer screening decisions.

PubMed

Mansley, E C; McKenna, M T

2001-10-06

As the fifth, and final, report in this Lancet series on health economics, we discuss how economic analyses in public health, with cancer screening as the example, differ depending on the perspective taken. We identify nine different, but related, decision makers at various levels, from the individual patient to society as a whole, and discuss how their different viewpoints affect their ultimate decisions. Central to our discussion is the identification of seven distinct components of perspective, each potentially important in the screening decision. In many fields of healthcare, decisions about the use of resources, such as time, wealth, or energy, are made by weighing up the positive and negative consequences of the alternatives under consideration and are thus based on an economic analysis of the situation (although sometimes this process is subconscious). For simplicity, we restrict our report to the effect of perspective on cancer screening decisions and show how the costs (negative consequences) and benefits (positive consequences) vary depending on the decision maker.

Using R for large spatiotemporal data sets

NASA Astrophysics Data System (ADS)

Pebesma, Edzer

2017-04-01

Writing and sharing scientific software is a means to communicate scientific ideas for finding scientific consensus, no more and no less than writing and sharing scientific papers is. Important factors for successful communication are adopting an open source environment, and using a language that is understood by many. For many scientist, R's combination of rich data abstraction and highly exposed data structures makes it an attractive communication tool. This paper discusses the development of spatial and spatiotemporal data handling and analysis with R since 2000, and will point to some of R's strengths and weaknesses in a historical perspective. We will also discuss a new, S3-based package for feature data ("Simple Features for R"), and point to a way forward into the data science realm, where pipeline-based workflows are assumed. Finally, we will discuss how, in a similar vein, massive satellite or climate model data sets, potentially held in a cloud environment, can be handled and analyzed with R.

Our Fat Future: Translating Adipose Stem Cell Therapy.

PubMed

Nordberg, Rachel C; Loboa, Elizabeth G

2015-09-01

Human adipose stem cells (hASCs) have the potential to treat patients with a variety of clinical conditions. Recent advancements in translational research, regulatory policy, and industry have positioned hASCs on the threshold of clinical translation. We discuss the progress and challenges of bringing adipose stem cell therapy into mainstream clinical use. This article details the advances made in recent years that have helped move human adipose stem cell therapy toward mainstream clinical use from a translational research, regulatory policy, and industrial standpoint. Four recurrent themes in translational technology as they pertain to human adipose stem cells are discussed: automated closed-system operations, biosensors and real-time monitoring, biomimetics, and rapid manufacturing. In light of recent FDA guidance documents, regulatory concerns about adipose stem cell therapy are discussed. Finally, an update is provided on the current state of clinical trials and the emerging industry that uses human adipose stem cells. This article is expected to stimulate future studies in translational adipose stem cell research. ©AlphaMed Press.

May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells.

PubMed

Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David A

2017-02-06

In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods.

Design Concept for a Minimal Volume Spacecraft Cabin to Serve as a Mars Ascent Vehicle Cabin and Other Alternative Pressurized Vehicle Cabins

NASA Technical Reports Server (NTRS)

Howard, Robert L., Jr.

2016-01-01

The Evolvable Mars Campaign is developing concepts for human missions to the surface of Mars. These missions are round-trip expeditions, thereby requiring crew launch via a Mars Ascent Vehicle (MAV). A study to identify the smallest possible pressurized cabin for this mission has developed a conceptual vehicle referred to as the minimal MAV cabin. The origin of this concept will be discussed as well as its initial concept definition. This will lead to a description of possible configurations to integrate the minimal MAV cabin with ascent vehicle engines and propellant tanks. Limitations of this concept will be discussed, in particular those that argue against the use of the minimal MAV cabin to perform the MAV mission. However, several potential alternative uses for the cabin are identified. Finally, recommended forward work will be discussed, including current work in progress to develop a full scale mockup and conduct usability evaluations.

Issues with data and analyses: Errors, underlying themes, and potential solutions

PubMed Central

Allison, David B.

2018-01-01

Some aspects of science, taken at the broadest level, are universal in empirical research. These include collecting, analyzing, and reporting data. In each of these aspects, errors can and do occur. In this work, we first discuss the importance of focusing on statistical and data errors to continually improve the practice of science. We then describe underlying themes of the types of errors and postulate contributing factors. To do so, we describe a case series of relatively severe data and statistical errors coupled with surveys of some types of errors to better characterize the magnitude, frequency, and trends. Having examined these errors, we then discuss the consequences of specific errors or classes of errors. Finally, given the extracted themes, we discuss methodological, cultural, and system-level approaches to reducing the frequency of commonly observed errors. These approaches will plausibly contribute to the self-critical, self-correcting, ever-evolving practice of science, and ultimately to furthering knowledge. PMID:29531079

Implications of Stellar Feedback for Dynamical Modeling of the Milky Way and Dwarf Galaxies

NASA Astrophysics Data System (ADS)

Wetzel, Andrew

2018-04-01

I will present recent results on dynamical modeling of stellar populations from the FIRE cosmological zoom-in baryonic simulations of Milky Way-like and dwarf galaxies. First, I will discuss the dynamical formation of the Milky Way, including the origin of thin+thick stellar disk morphology. I also will discuss the curious origin of metal-rich stars on halo-like orbits near the Sun, as recently measured by Gaia, with new insights from FIRE simulations on stellar radial migration/heating. Next, I will discuss role of stellar feedback in generating non-equilibrium fluctuations of the gravitational potential in low-mass 'dwarf' galaxies, which can explain the origin of cores in their dark-matter density profiles. In particular, we predict significant observable effects on stellar dynamics, including radial migration, size fluctuations, and population gradients, which can provide observational tests of feedback-driven core formation. Finally, this scenario can explain the formation of newly discovered 'ultra-diffuse' galaxies.

The protons of space and brain tumors II. Cellular and molecular considerations

NASA Astrophysics Data System (ADS)

Nagle, W. A.; Moss, A. J.; Dalrymple, G. V.; Cox, A. B.; Wigle, J. F.; Mitchell, J. C.

1989-05-01

An increased incidence of highly malignant gliomas, termed glioblastoma multiforme has been observed in Rhesus monkeys irradiated with 55 MeV protons, and in humans treated with therapeutic irradiation to the head. The results suggest a radiation etiology for these tumors. In this paper, we review briefly some characteristics of glioma tumors, and summarize the genetic changes associated with malignant gliomas in experimental animals and in humans. The genetic abnormalities include cytogenetic alterations, and changes in the structure and expression of specific oncogenes. We discuss the potential for these genetic changes to contribute to several putative mechanism leading to aberrant growth stimulation and, ultimately, to tumorigenesis. In addition, we review briefly some recent data concerning the molecular nature of radiation-induced somatic cell mutation and oncogene activation, and discuss the significance of these results for the radiation etiology of malignant gliomas. Finally, some implications of these results are discussed in relation to human radiation exposure in space.

Field of smart structures as seen by those working in it: survey results

NASA Astrophysics Data System (ADS)

Spillman, William B., Jr.; Sirkis, James S.; Gardiner, Peter T.

1995-04-01

There has been considerable discussion in the technical community on a number of questions concerned with smart materials and structures, such as what they are, whether smart materials can be considered a subset of smart structures, whether a smart structure and an intelligent structure are the same thing, etc. This discussion is both fueled and confused by the technical community due to the truly multidisciplinary nature of this new field. Smart materials and structures research involves so many technically diverse fields that it is quite common for one field to completely misunderstand the terminology and state-of-the-art in other fields. In order to ascertain whether a consensus is emerging on a number of these questions, the technical community was surveyed in a number of ways including via the Internet and by direct contact. The purpose of this survey in the final analysis was to better define the smart materials and structures field, its current status and its potential benefits. Results of the survey are presented and discussed.

NACA Zero Power Reactor Facility Hazards Summary

NASA Technical Reports Server (NTRS)

1957-01-01

The Lewis Flight Propulsion Laboratory of the National Advisory Committee for Aeronautics proposes to build a zero power research reactor facility which will be located in the laboratory grounds near Clevelaurd, Ohio. The purpose of this report is to inform the Advisory Commit tee on Reactor Safeguards of the U. S. Atomic Energy Commission in re gard to the design of the reactor facility, the cha,acteristics of th e site, and the hazards of operation at this location, The purpose o f this reactor is to perform critical experiments, to measure reactiv ity effects, to serve as a neutron source, and to serve as a training tool. The reactor facility is described. This is followed by a discu ssion of the nuclear characteristics and the control system. Site cha racteristics are then discussed followed by a discussion of the exper iments which may be conducted in the facility. The potential hazards of the facility are then considered, particularly, the maximum credib le accident. Finally, the administrative procedure is discussed.

May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells

PubMed Central

Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David. A.

2017-01-01

In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods. PMID:28178187

Sex-differential heterologous (non-specific) effects of vaccines: an emerging public health issue that needs to be understood and exploited.

PubMed

Flanagan, Katie L; Plebanski, Magdalena

2017-01-01

Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential. This review discusses the evidence, mechanisms and public health implications of the non-specific effects of vaccines (NSEs). Areas covered: This article firstly discusses the World Health Organization systematic review of the evidence for sex-differential heterologous effects of vaccines, and further PubMed indexed studies on NSEs on susceptibility to infectious diseases, allergy, autoimmunity and malignancy in animals and humans. Potential immunological mechanisms are evaluated, including sex-differential effects. Finally it describes how advances in systems biology might be applied to study such effects. Expert commentary: This section points out the need to understand immune mechanisms in order to exploit beneficial vaccine effects, and diminish deleterious ones. It suggests analysis of vaccine effects by sex is important, and discusses the future for personalised vaccines that take these effects into account.

Effects of Cannabis on Neurocognitive Functioning: Recent Advances, Neurodevelopmental Influences, and Sex Differences

PubMed Central

Crane, Natania A.; Schuster, Randi Melissa; Fusar-Poli, Paolo; Gonzalez, Raul

2012-01-01

Decades of research have examined the effects of cannabis on neurocognition. Recent advances in this field provide us with a better understanding of how cannabis use influences neurocognition both acutely (during intoxication) and non-acutely (after acute effects subside). Evidence of problems with episodic memory is one of the most consistent findings reported; however, several other neurocognitive domains appear to be adversely affected by cannabis use under various conditions. There is significant variability in findings across studies, thus a discussion of potential moderators is increasingly relevant. The purpose of this review was to 1) provide an update on research of cannabis’ acute and non-acute effects on neurocognition, with a focus on findings since 2007 and 2) suggest and discuss how neurodevelopmental issues and sex differences may influence cannabis effects on neurocognition. Finally we discuss how future investigations may lead to better understanding of the complex interplay among cannabis, stages of neurodevelopment, and sex on neurocognitive functioning. PMID:23129391

Toward production from gas hydrates: Current status, assessment of resources, and simulation-based evaluation of technology and potential

USGS Publications Warehouse

Moridis, G.J.; Collett, T.S.; Boswell, R.; Kurihara, M.; Reagan, M.T.; Koh, C.; Sloan, E.D.

2009-01-01

Gas hydrates (GHs) are a vast energy resource with global distribution in the permafrost and in the oceans. Even if conservative estimates are considered and only a small fraction is recoverable, the sheer size of the resource is so large that it demands evaluation as a potential energy source. In this review paper, we discuss the distribution of natural GH accumulations, the status of the primary international research and development (R&D) programs, and the remaining science and technological challenges facing the commercialization of production. After a brief examination of GH accumulations that are well characterized and appear to be models for future development and gas production, we analyze the role of numerical simulation in the assessment of the hydrate-production potential, identify the data needs for reliable predictions, evaluate the status of knowledge with regard to these needs, discuss knowledge gaps and their impact, and reach the conclusion that the numerical-simulation capabilities are quite advanced and that the related gaps either are not significant or are being addressed. We review the current body of literature relevant to potential productivity from different types of GH deposits and determine that there are consistent indications of a large production potential at high rates across long periods from a wide variety of hydrate deposits. Finally, we identify (a) features, conditions, geology and techniques that are desirable in potential production targets; (b) methods to maximize production; and (c) some of the conditions and characteristics that render certain GH deposits undesirable for production. Copyright ?? 2009 Society of Petroleum Engineers.

Toward production from gas hydrates: Current status, assessment of resources, and simulation-based evaluation of technology and potential

USGS Publications Warehouse

Moridis, G.J.; Collett, T.S.; Boswell, R.; Kurihara, M.; Reagan, M.T.; Koh, C.; Sloan, E.D.

2008-01-01

Gas hydrates are a vast energy resource with global distribution in the permafrost and in the oceans. Even if conservative estimates are considered and only a small fraction is recoverable, the sheer size of the resource is so large that it demands evaluation as a potential energy source. In this review paper, we discuss the distribution of natural gas hydrate accumulations, the status of the primary international R&D programs, and the remaining science and technological challenges facing commercialization of production. After a brief examination of gas hydrate accumulations that are well characterized and appear to be models for future development and gas production, we analyze the role of numerical simulation in the assessment of the hydrate production potential, identify the data needs for reliable predictions, evaluate the status of knowledge with regard to these needs, discuss knowledge gaps and their impact, and reach the conclusion that the numerical simulation capabilities are quite advanced and that the related gaps are either not significant or are being addressed. We review the current body of literature relevant to potential productivity from different types of gas hydrate deposits, and determine that there are consistent indications of a large production potential at high rates over long periods from a wide variety of hydrate deposits. Finally, we identify (a) features, conditions, geology and techniques that are desirable in potential production targets, (b) methods to maximize production, and (c) some of the conditions and characteristics that render certain gas hydrate deposits undesirable for production. Copyright 2008, Society of Petroleum Engineers.

Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects

PubMed Central

Schoellhammer, Carl M.; Blankschtein, Daniel; Langer, Robert

2014-01-01

Introduction Transdermal delivery has potential advantages over other routes of administration. It could reduce first-pass metabolism associated with oral delivery and is less painful than injections. However, the outermost layer of the skin, the stratum corneum (SC), limits passive diffusion to small lipophilic molecules. Therefore, methods are needed to safely permeabilize the SC so that ionic and larger molecules may be delivered transdermally. Areas Covered This review focuses on low-frequency sonophoresis, microneedles, electroporation and iontophoresis, and combinations of these methods to permeabilize the SC. The mechanisms of enhancement and developments in the last five years are discussed. Potentially high-impact applications, including protein delivery, vaccination, and sensing, are presented. Finally, commercial interest and clinical trials are discussed. Expert Opinion Not all permeabilization methods are appropriate for all applications. Focused studies into applications utilizing the advantages of each method are needed. The total dose and kinetics of delivery must be considered. Vaccination is one application where permeabilization methods could make an impact. Protein delivery and analyte sensing are also areas of potential impact, although the amount of material that can be delivered (or extracted) is of critical importance. Additional work on the miniaturization of these technologies will help to increase commercial interest. PMID:24392787

How does the urothelium affect bladder function in health and disease? ICI-RS 2011.

PubMed

Birder, L A; Ruggieri, M; Takeda, M; van Koeveringe, G; Veltkamp, S; Korstanje, C; Parsons, B; Fry, C H

2012-03-01

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally, consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery. Copyright © 2012 Wiley Periodicals, Inc.

Casimir effect in rugby-ball type flux compactifications

NASA Astrophysics Data System (ADS)

Elizalde, Emilio; Minamitsuji, Masato; Naylor, Wade

2007-03-01

As a continuation of the work by Minamitsuji, Naylor, and Sasaki [J. High Energy Phys.JHEPFG1029-8479 12 (2006) 07910.1088/1126-6708/2006/12/079], we discuss the Casimir effect for a massless bulk scalar field in a 4D toy model of a 6D warped flux compactification model, to stabilize the volume modulus. The one-loop effective potential for the volume modulus has a form similar to the Coleman-Weinberg potential. The stability of the volume modulus against quantum corrections is related to an appropriate heat kernel coefficient. However, to make any physical predictions after volume stabilization, knowledge of the derivative of the zeta function, ζ'(0) (in a conformally related spacetime) is also required. By adding up the exact mass spectrum using zeta-function regularization, we present a revised analysis of the effective potential. Finally, we discuss some physical implications, especially concerning the degree of the hierarchy between the fundamental energy scales on the branes. For a larger degree of warping our new results are very similar to the ones given by Minamitsuji, Naylor, and Sasaki [J. High Energy Phys.JHEPFG1029-8479 12 (2006) 07910.1088/1126-6708/2006/12/079] and imply a larger hierarchy. In the nonwarped (rugby ball) limit the ratio tends to converge to the same value, independently of the bulk dilaton coupling.

Collaboration in health services research: on developing relationships between VA researchers and those in other institutions.

PubMed Central

Greenlick, M R; Freeborn, D K

1986-01-01

This article explores the potential for collaboration between investigators in institutions outside of the VA and those engaged in research within the VA. The focus is on the potential for collaborative work in health services research; our perspective is that of researchers in a freestanding HMO research center affiliated with the Veterans Administration's Northwest Health Services Research and Development Field Program. The paper begins with a review of the reasons that make collaboration between VA researchers and other health services researchers so appropriate at this time. An example of collaboration is presented, drawing on the experience of the Northwest Field Program and the Kaiser Permanente Center for Health Research. Finally, some difficulties inherent in collaboration between VA and other health services researchers are discussed. PMID:3512485

Reactor antineutrino shoulder explained by energy scale nonlinearities?

NASA Astrophysics Data System (ADS)

Mention, G.; Vivier, M.; Gaffiot, J.; Lasserre, T.; Letourneau, A.; Materna, T.

2017-10-01

The Daya Bay, Double Chooz and RENO experiments recently observed a significant distortion in their detected reactor antineutrino spectra, being at odds with the current predictions. Although such a result suggests to revisit the current reactor antineutrino spectra modeling, an alternative scenario, which could potentially explain this anomaly, is explored in this letter. Using an appropriate statistical method, a study of the Daya Bay experiment energy scale is performed. While still being in agreement with the γ calibration data and 12B measured spectrum, it is shown that a O (1%) deviation of the energy scale reproduces the distortion observed in the Daya Bay spectrum, remaining within the quoted calibration uncertainties. Potential origins of such a deviation, which challenge the energy calibration of these detectors, are finally discussed.

Shape matters: The case for Ellipsoids and Ellipsoidal Water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tillack, Andreas F.; Robinson, Bruce H.

We describe the shape potentials used for the van der Waals interactions between soft-ellipsoids used to coarse-grain molecular moieties in our Metropolis Monte-Carlo simulation software. The morphologies resulting from different expressions for these van der Waals interaction potentials are discussed for the case of a prolate spheroid system with a strong dipole at the ellipsoid center. We also show that the calculation of ellipsoids is, at worst, only about fivefold more expensive computationally when compared to a simple Lennard- Jones sphere. Finally, as an application of the ellipsoidal shape we parametrize water from the original SPC water model and observemore » – just through the difference in shape alone – a significant improvement of the O-O radial distribution function when compared to experimental data.« less

Encounters in an online brand community: development and validation of a metric for value co-creation by customers.

PubMed

Hsieh, Pei-Ling

2015-05-01

Recent developments in service marketing have demonstrated the potential value co-creation by customers who participate in online brand communities (OBCs). Therefore, this study forecasts the co-created value by understanding the participation/behavior of customers in a multi-stakeholder OBC. This six-phase qualitative and quantitative investigation conceptualizes, constructs, refines, and tests a 12-item three-dimensional scale for measuring key factors that are related to the experience, interpersonal interactions, and social relationships that affect the value co-creation by customers in an OBC. The scale captures stable psychometric properties, measured using various reliability and validity tests, and can be applied across various industries. Finally, the utility implications and limitations of the proposed scale are discussed, and potential future research directions considered.

Potential flow theory and operation guide for the panel code PMARC

NASA Technical Reports Server (NTRS)

Ashby, Dale L.; Dudley, Michael R.; Iguchi, Steve K.; Browne, Lindsey; Katz, Joseph

1991-01-01

The theoretical basis for PMARC, a low-order potential-flow panel code for modeling complex three-dimensional geometries, is outlined. Several of the advanced features currently included in the code, such as internal flow modeling, a simple jet model, and a time-stepping wake model, are discussed in some detail. The code is written using adjustable size arrays so that it can be easily redimensioned for the size problem being solved and the computer hardware being used. An overview of the program input is presented, with a detailed description of the input available in the appendices. Finally, PMARC results for a generic wing/body configuration are compared with experimental data to demonstrate the accuracy of the code. The input file for this test case is given in the appendices.

The HVT technique and the 'uncertainty' relation for central potentials

NASA Astrophysics Data System (ADS)

Grypeos, M. E.; Koutroulos, C. G.; Oyewumi, K. J.; Petridou, Th

2004-08-01

The quantum mechanical hypervirial theorems (HVT) technique is used to treat the so-called 'uncertainty' relation for quite a general class of central potential wells, including the (reduced) Poeschl-Teller and the Gaussian one. It is shown that this technique is quite suitable in deriving an approximate analytic expression in the form of a truncated power series expansion for the dimensionless product Pnl equiv langr2rangnllangp2rangnl/planck2, for every (deeply) bound state of a particle moving non-relativistically in the well, provided that a (dimensionless) parameter s is sufficiently small. Attention is also paid to a number of cases, among the limited existing ones, in which exact analytic or semi-analytic expressions for Pnl can be derived. Finally, numerical results are given and discussed.

Chirality and gravitational parity violation.

PubMed

Bargueño, Pedro

2015-06-01

In this review, parity-violating gravitational potentials are presented as possible sources of both true and false chirality. In particular, whereas phenomenological long-range spin-dependent gravitational potentials contain both truly and falsely chiral terms, it is shown that there are models that extend general relativity including also coupling of fermionic degrees of freedom to gravity in the presence of torsion, which give place to short-range truly chiral interactions similar to that usually considered in molecular physics. Physical mechanisms which give place to gravitational parity violation together with the expected size of the effects and their experimental constraints are discussed. Finally, the possible role of parity-violating gravity in the origin of homochirality and a road map for future research works in quantum chemistry is presented. © 2015 Wiley Periodicals, Inc.

A review of contamination of surface-, ground-, and drinking water in Sweden by perfluoroalkyl and polyfluoroalkyl substances (PFASs).

PubMed

Banzhaf, Stefan; Filipovic, Marko; Lewis, Jeffrey; Sparrenbom, Charlotte J; Barthel, Roland

2017-04-01

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are found in aquatic systems, flora, and fauna worldwide. These potentially harmful compounds are also frequently detected in Sweden and have already resulted in severe problems for public drinking water supply, i.e., some wells had to be closed due to high PFAS concentrations both in raw water and produced drinking water. Knowledge on PFAS occurrence in Sweden is still quite low, although monitoring is currently ongoing. This work describes potential sources for PFASs to enter the drinking water supply in Sweden and compares different occurrences of PFASs in raw and drinking water in the country. Moreover, the monitoring history, the legal situation, and remediation actions taken are presented. Finally, future challenges and the way forward in Sweden are discussed.

Just entertainment: effects of TV series about intrigue on young adults

PubMed Central

Wang, Fei; Lin, Shengdong; Ke, Xue

2015-01-01

The potential harmful effects of media violence have been studied systematically and extensively. However, very little attention has been devoted to the intrigue and struggles between people depicted in the mass media. A longitudinal randomized experimental group-control group, pretest–posttest design study was conducted to examine the potential effects of this type of TV series on young adults. A typical and popular TV series was select as a stimulus. By scrutinizing the outline of this TV series and inspired by studies of the effects of media violence, one behavioral observation and five scales were adopted as dependent measures. The study did not find any effect of the intrigue TV series on any of the six dependent variables. Finally, possible interference variables or moderators were discussed. PMID:26029127

Analytical solutions for the dynamics of two trapped interacting ultracold atoms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Idziaszek, Zbigniew; Calarco, Tommaso; CNR-INFM BEC Center, I-38050 Povo

2006-08-15

We discuss exact solutions of the Schroedinger equation for the system of two ultracold atoms confined in an axially symmetric harmonic potential. We investigate different geometries of the trapping potential, in particular we study the properties of eigenenergies and eigenfunctions for quasi-one-dimensional and quasi-two-dimensional traps. We show that the quasi-one-dimensional and the quasi-two-dimensional regimes for two atoms can be already realized in the traps with moderately large (or small) ratios of the trapping frequencies in the axial and the transverse directions. Finally, we apply our theory to Feshbach resonances for trapped atoms. Introducing in our description an energy-dependent scattering lengthmore » we calculate analytically the eigenenergies for two trapped atoms in the presence of a Feshbach resonance.« less

Staff exchange with Chemical Waste Management. Final project report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrer, B.J.; Barak, D.W.

1993-12-01

Original objective was transfer of PNL technology and expertise in computational chemistry and waste flow/treatment modeling to CWM. Identification and characterization of a broader portfolio of PNL`s environmental remediation technologies with high potential for rapid application became the focus of the exchange, which included E-mail exchanges. Of the 14 technologies discussed, the following were identified as being of high interest to CWM: six phase soil heating (in-situ heating), high energy electrical corona, RAAS/ReOpt{trademark} (remedial, expert system), TEES{trademark} (catalytic production of methane from biological wastes), PST (process for treating petroleum sludge). CWM`s reorganization and downsizing reduced the potential benefits to industry,more » but a proposal for transfer and application of PST to Wheelabrator was made.« less

Atmospheric Chemistry and Air Pollution

DOE PAGES

Gaffney, Jeffrey S.; Marley, Nancy A.

2003-01-01

Atmospheric chemistry is an important discipline for understanding air pollution and its impacts. This mini-review gives a brief history of air pollution and presents an overview of some of the basic photochemistry involved in the production of ozone and other oxidants in the atmosphere. Urban air quality issues are reviewed with a specific focus on ozone and other oxidants, primary and secondary aerosols, alternative fuels, and the potential for chlorine releases to amplify oxidant chemistry in industrial areas. Regional air pollution issues such as acid rain, long-range transport of aerosols and visibility loss, and the connections of aerosols to ozonemore » and peroxyacetyl nitrate chemistry are examined. Finally, the potential impacts of air pollutants on the global-scale radiative balances of gases and aerosols are discussed briefly.« less

Soft template synthesis of yolk/silica shell particles.

PubMed

Wu, Xue-Jun; Xu, Dongsheng

2010-04-06

Yolk/shell particles possess a unique structure that is composed of hollow shells that encapsulate other particles but with an interstitial space between them. These structures are different from core/shell particles in that the core particles are freely movable in the shell. Yolk/shell particles combine the properties of each component, and can find potential applications in catalysis, lithium ion batteries, and biosensors. In this Research News article, a soft-template-assisted method for the preparation of yolk/silica shell particles is presented. The demonstrated method is simple and general, and can produce hollow silica spheres incorporated with different particles independent of their diameters, geometry, and composition. Furthermore, yolk/mesoporous silica shell particles and multishelled particles are also prepared through optimization of the experimental conditions. Finally, potential applications of these particles are discussed.

Regulating the advertising of genetic tests in Europe: a balancing act.

PubMed

Kalokairinou, Louiza; Borry, Pascal; Howard, Heidi Carmen

2017-10-01

Direct-to-consumer (DTC) genetic tests (GT) have provoked criticism over their potential adverse impact on public health. The European Parliament called for a ban on DTC advertising of GT during the debate for the adoption of a European Regulation on in vitro diagnostic medical devices. This proposal, however, was not ultimately retained in the final text. Instead, the regulation includes an article prohibiting misleading claims for this kind of advertising. These two different approaches raise questions about the optimal degree of regulation. Herein, we provide an overview of the ways GT have been advertised and related ethical issues. Subsequently, the laws regulating the advertising of GT at the European Union and national level are examined. Finally, recent regulatory developments are discussed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Bioremediation and detoxification of industrial wastes by earthworms: Vermicompost as powerful crop nutrient in sustainable agriculture.

PubMed

Bhat, Sartaj Ahmad; Singh, Sharanpreet; Singh, Jaswinder; Kumar, Sunil; Bhawana; Vig, Adarsh Pal

2018-03-01

Vermicompost is the final product of the vermicomposting process involving the collective action of earthworms and microbes. During this process, the waste is converted into useful manure by reducing the harmful effects of waste. Toxicity of industrial wastes is evaluated by plant bioassays viz. Allium cepa and Vicia faba test. These bioassays are sensitive and cost-effective for the monitoring of environmental contamination. The valorization potential of earthworms and their ability to detoxify heavy metals in industrial wastes is because of their strong metabolic system and involvement of earthworm gut microbes and chloragocyte cells. Most of the studies reported that the vermicompost produced from organic wastes contains higher amounts of humic substances, which plays a major role in growth of plants. The present article discusses the detoxification of industrial wastes by earthworms and the role of final vermicompost in plant growth and development. Copyright © 2018 Elsevier Ltd. All rights reserved.

Lignin from Micro- to Nanosize: Applications

PubMed Central

Friedl, Anton

2017-01-01

Micro- and nanosize lignin has recently gained interest due to improved properties compared to standard lignin available today. As the second most abundant biopolymer after cellulose, lignin is readily available but used for rather low-value applications. This review focuses on the application of micro- and nanostructured lignin in final products or processes that all show potential for high added value. The fields of application are ranging from improvement of mechanical properties of polymer nanocomposites, bactericidal and antioxidant properties and impregnations to hollow lignin drug carriers for hydrophobic and hydrophilic substances. Also, a carbonization of lignin nanostructures can lead to high-value applications such as use in supercapacitors for energy storage. The properties of the final product depend on the surface properties of the nanomaterial and, therefore, on factors like the lignin source, extraction method, and production/precipitation methods, as discussed in this review. PMID:29117142

Thermal-electric coupled-field finite element modeling and experimental testing of high-temperature ion sources for the production of radioactive ion beams

NASA Astrophysics Data System (ADS)

Manzolaro, M.; Meneghetti, G.; Andrighetto, A.; Vivian, G.; D'Agostini, F.

2016-02-01

In isotope separation on line facilities the target system and the related ion source are two of the most critical components. In the context of the selective production of exotic species (SPES) project, a 40 MeV 200 μA proton beam directly impinges a uranium carbide target, generating approximately 1013 fissions per second. The radioactive isotopes produced in this way are then directed to the ion source, where they can be ionized and finally accelerated to the subsequent areas of the facility. In this work both the surface ion source and the plasma ion source adopted for the SPES facility are presented and studied by means of numerical thermal-electric models. Then, numerical results are compared with temperature and electric potential difference measurements, and finally the main advantages of the proposed simulation approach are discussed.

Presence of pro-tobacco messages on the Web.

PubMed

Hong, Traci; Cody, Michael J

2002-01-01

Ignored in the finalized Master Settlement Agreement (National Association of Attorneys General, 1998), the unmonitored, unregulated World Wide Web (Web) can operate as a major vehicle for delivering pro-tobacco messages, images, and products to millions of young consumers. A content analysis of 318 randomly sampled pro-tobacco Web sites revealed that tobacco has a pervasive presence on the Web, especially on e-commerce sites and sites featuring hobbies, recreation, and "fetishes." Products can be ordered online on nearly 50% of the sites, but only 23% of the sites included underage verification. Further, only 11% of these sites contain health warnings. Instead, pro-tobacco sites frequently associate smoking with "glamorous" and "alternative" lifestyles, and with images of young males and young (thin, attractive) females. Finally, many of the Web sites offered interactive site features that are potentially appealing to young Web users. Recommendations for future research and counterstrategies are discussed.

Symmetry restored in dibosons at the LHC?

DOE PAGES

Brehmer, Johann; Hewett, JoAnne; Kopp, Joachim; ...

2015-10-28

A number of LHC resonance search channels display an excess in the invariant mass region of 1.8–2.0 TeV. Among them is a 3.4σ excess in the fully hadronic decay of a pair of Standard Model electroweak gauge bosons, in addition to potential signals in the HW and dijet final states. We perform a model-independent cross-section fit to the results of all ATLAS and CMS searches sensitive to these final states. We then interpret these results in the context of the Left-Right Symmetric Model, based on the extended gauge group SU(2) L × SU(2) R × U(1)', and show that amore » heavy right-handed gauge boson W R can naturally explain the current measurements with just a single coupling g R ~ 0.4. Thus, we discuss a possible connection to dark matter.« less

Source-sink interaction: a century old concept under the light of modern molecular systems biology.

PubMed

Chang, Tian-Gen; Zhu, Xin-Guang; Raines, Christine

2017-07-20

Many approaches to engineer source strength have been proposed to enhance crop yield potential. However, a well-co-ordinated source-sink relationship is required finally to realize the promised increase in crop yield potential in the farmer's field. Source-sink interaction has been intensively studied for decades, and a vast amount of knowledge about the interaction in different crops and under different environments has been accumulated. In this review, we first introduce the basic concepts of source, sink and their interactions, then summarize current understanding of how source and sink can be manipulated through both environmental control and genetic manipulations. We show that the source-sink interaction underlies the diverse responses of crops to the same perturbations and argue that development of a molecular systems model of source-sink interaction is required towards a rational manipulation of the source-sink relationship for increased yield. We finally discuss both bottom-up and top-down routes to develop such a model and emphasize that a community effort is needed for development of this model. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Emerging nondestructive inspection methods for aging aircraft

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beattie, A; Dahlke, L; Gieske, J

This report identifies and describes emerging nondestructive inspection (NDI) methods that can potentially be used to inspect commercial transport and commuter aircraft for structural damage. The nine categories of emerging NDI techniques are: acoustic emission, x-ray computed tomography, backscatter radiation, reverse geometry x-ray, advanced electromagnetics, including magnetooptic imaging and advanced eddy current techniques, coherent optics, advanced ultrasonics, advanced visual, and infrared thermography. The physical principles, generalized performance characteristics, and typical applications associated with each method are described. In addition, aircraft inspection applications are discussed along with the associated technical considerations. Finally, the status of each technique is presented, with amore » discussion on when it may be available for use in actual aircraft maintenance programs. It should be noted that this is a companion document to DOT/FAA/CT-91/5, Current Nondestructive Inspection Methods for Aging Aircraft.« less

Higher symmetries of the Schrödinger operator in Newton-Cartan geometry

NASA Astrophysics Data System (ADS)

Gundry, James

2017-03-01

We establish several relationships between the non-relativistic conformal symmetries of Newton-Cartan geometry and the Schrödinger equation. In particular we discuss the algebra sch(d) of vector fields conformally-preserving a flat Newton-Cartan spacetime, and we prove that its curved generalisation generates the symmetry group of the covariant Schrödinger equation coupled to a Newtonian potential and generalised Coriolis force. We provide intrinsic Newton-Cartan definitions of Killing tensors and conformal Schrödinger-Killing tensors, and we discuss their respective links to conserved quantities and to the higher symmetries of the Schrödinger equation. Finally we consider the role of conformal symmetries in Newtonian twistor theory, where the infinite-dimensional algebra of holomorphic vector fields on twistor space corresponds to the symmetry algebra cnc(3) on the Newton-Cartan spacetime.

The Drosophila melanogaster host model

PubMed Central

Igboin, Christina O.; Griffen, Ann L.; Leys, Eugene J.

2012-01-01

The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen–host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of bacterial pathogenesis and host defence mechanisms between higher host organisms and Drosophila. This review presents an in-depth discussion of the Drosophila immune response, the Drosophila killing model, and the use of the model to examine bacterial–host interactions. The recent introduction of the Drosophila model into the oral microbiology field is discussed, specifically the use of the model to examine Porphyromonas gingivalis–host interactions, and finally the potential uses of this powerful model system to further elucidate oral bacterial-host interactions are addressed. PMID:22368770

The Drosophila melanogaster host model.

PubMed

Igboin, Christina O; Griffen, Ann L; Leys, Eugene J

2012-01-01

The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen-host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of bacterial pathogenesis and host defence mechanisms between higher host organisms and Drosophila. This review presents an in-depth discussion of the Drosophila immune response, the Drosophila killing model, and the use of the model to examine bacterial-host interactions. The recent introduction of the Drosophila model into the oral microbiology field is discussed, specifically the use of the model to examine Porphyromonas gingivalis-host interactions, and finally the potential uses of this powerful model system to further elucidate oral bacterial-host interactions are addressed.

Bacteriophages Infecting Propionibacterium acnes

PubMed Central

2013-01-01

Viruses specifically infecting bacteria, or bacteriophages, are the most common biological entity in the biosphere. As such, they greatly influence bacteria, both in terms of enhancing their virulence and in terms of killing them. Since the first identification of bacteriophages in the beginning of the 20th century, researchers have been fascinated by these microorganisms and their ability to eradicate bacteria. In this review, we will cover the history of the Propionibacterium acnes bacteriophage research and point out how bacteriophage research has been an important part of the research on P. acnes itself. We will further discuss recent findings from phage genome sequencing and the identification of phage sequence signatures in clustered regularly interspaced short palindromic repeats (CRISPRs). Finally, the potential to use P. acnes bacteriophages as a therapeutic strategy to combat P. acnes-associated diseases will be discussed. PMID:23691509

Practical considerations in Bayesian fusion of point sensors

NASA Astrophysics Data System (ADS)

Johnson, Kevin; Minor, Christian

2012-06-01

Sensor data fusion is and has been a topic of considerable research, but rigorous and quantitative understanding of the benefits of fusing specific types of sensor data remains elusive. Often, sensor fusion is performed on an ad hoc basis with the assumption that overall detection capabilities will improve, only to discover later, after expensive and time consuming laboratory and/or field testing that little advantage was gained. The work presented here will discuss these issues with theoretical and practical considerations in the context of fusing chemical sensors with binary outputs. Results are given for the potential performance gains one could expect with such systems, as well as the practical difficulties involved in implementing an optimal Bayesian fusion strategy with realistic scenarios. Finally, a discussion of the biases that inaccurate statistical estimates introduce into the results and their consequences is presented.

Final Report of the Haystack Orbital Debris Data Review Panel

NASA Technical Reports Server (NTRS)

Barton, David K.; Brillinger, David; McDaniel, Patrick; Pollock, Kenneth H.; El-Shaarawi, A. H.; Tuley, Michael T.

1998-01-01

The Haystack Orbital Debris Data Review Panel was established in December 1996 to consider the adequacy of the data on orbital debris gathered over the past several years with the Haystack radar, and the accuracy of the methods used to estimate the flux vs. size relationship for this debris. The four specific issues addressed for the Panel were: 1. The number of observations relative to the estimated population of interest 2. The inherent ambiguity between the measured radar cross section (RCS) and the inferred physical size of the object 3. The inherent aspect angle limitation in viewing each object and its relationship to object geometry 4. The adequacy of the sample data set to characterize the debris population's potential geometry. Further discussion and interpretation of these issues, and identification of the detailed questions contributing to them, are discussed in this report.

A social capital approach to the prevention of elder mistreatment.

PubMed

Donohue, William A; Dibble, Jayson L; Schiamberg, Lawrence B

2008-01-01

The current demographic landscape features an increasing number of elderly individuals in the care of some trusted other. Being cared for by a trusted other raises the potential for mistreatment of the elder by that trusted other. The goal of this paper is to explore the possibility of preventing elder mistreatment by increasing the bridging and bonding social capital available to caretakers. Attending to social capital lets researchers expand their focus toward areas rarely examined through current stress-outcome models (e.g., interpersonal interactions). First, elder mistreatment and social capital are defined and discussed. Then, a model is forwarded that details how social capital might mitigate the effects of caretaker stress and decrease the probability that caretakers will engage in elder mistreatment in both home and long-term care institutional settings. Finally, implications for future research and practical intervention are discussed.

NASA's progress in nuclear electric propulsion technology

NASA Technical Reports Server (NTRS)

Stone, James R.; Doherty, Michael P.; Peecook, Keith M.

1993-01-01

The National Aeronautics and Space Administration (NASA) has established a requirement for Nuclear Electric Propulsion (NEP) technology for robotic planetary science mission applications with potential future evolution to systems for piloted Mars vehicles. To advance the readiness of NEP for these challenging missions, a near-term flight demonstration on a meaningful robotic science mission is very desirable. The requirements for both near-term and outer planet science missions are briefly reviewed, and the near-term baseline system established under a recent study jointly conducted by the Lewis Research Center (LeRC) and the Jet Propulsion Laboratory (JPL) is described. Technology issues are identified where work is needed to establish the technology for the baseline system, and technology opportunities which could provide improvement beyond baseline capabilities are discussed. Finally, the plan to develop this promising technology is presented and discussed.

Excitons in Single-Walled Carbon Nanotubes and Their Dynamics

NASA Astrophysics Data System (ADS)

Amori, Amanda R.; Hou, Zhentao; Krauss, Todd D.

2018-04-01

Understanding exciton dynamics in single-walled carbon nanotubes (SWCNTs) is essential to unlocking the many potential applications of these materials. This review summarizes recent progress in understanding exciton photophysics and, in particular, exciton dynamics in SWCNTs. We outline the basic physical and electronic properties of SWCNTs, as well as bright and dark transitions within the framework of a strongly bound one-dimensional excitonic model. We discuss the many facets of ultrafast carrier dynamics in SWCNTs, including both single-exciton states (bright and dark) and multiple-exciton states. Photophysical properties that directly relate to excitons and their dynamics, including exciton diffusion lengths, chemical and structural defects, environmental effects, and photoluminescence photon statistics as observed through photon antibunching measurements, are also discussed. Finally, we identify a few key areas for advancing further research in the field of SWCNT excitons and photonics.

Deciphering the contribution of intrinsic and synaptic currents to the effects of transient synaptic inputs on human motor unit discharge

PubMed Central

Powers, Randall K.; Türker, Kemal S.

2010-01-01

The amplitude and time course of synaptic potentials in human motoneurons can be estimated in tonically discharging motor units by measuring stimulus-evoked changes in the rate and probability of motor unit action potentials. However, in spite of the fact that some of these techniques have been used for over thirty years, there is still no consensus on the best way to estimate the characteristics of synaptic potentials or on the accuracy of these estimates. In this review, we compare different techniques for estimating synaptic potentials from human motor unit discharge and also discuss relevant animal models in which estimated synaptic potentials can be compared to those directly measured from intracellular recordings. We also review the experimental evidence on how synaptic noise and intrinsic motoneuron properties influence their responses to synaptic inputs. Finally, we consider to what extent recordings of single motor unit discharge in humans can be used to distinguish the contribution of changes in synaptic inputs versus changes in intrinsic motoneuron properties to altered motoneuron responses following CNS injury. PMID:20427230

Regional Recovery of the Disturbing Gravitational Potential from Satellite Observations of First-, Second- and Third-order Radial Derivatives of the Disturbing Gravitational Potential

NASA Astrophysics Data System (ADS)

Novak, P.; Pitonak, M.; Sprlak, M.

2015-12-01

Recently realized gravity-dedicated satellite missions allow for measuring values of scalar, vectorial (Gravity Recovery And Climate Experiment - GRACE) and second-order tensorial (Gravity field and steady-state Ocean Circulation Explorer - GOCE) parameters of the Earth's gravitational potential. Theoretical aspects related to using moving sensors for measuring elements of a third-order gravitational tensor are currently under investigation, e.g. the gravity-dedicated satellite mission OPTIMA (OPTical Interferometry for global Mass change detection from space) should measure third-order derivatives of the Earth's gravitational potential. This contribution investigates regional recovery of the disturbing gravitational potential on the Earth's surface from satellite observations of first-, second- and third-order radial derivatives of the disturbing gravitational potential. Synthetic measurements along a satellite orbit at the altitude of 250 km are synthetized from the global gravitational model EGM2008 and polluted by the Gaussian noise. The process of downward continuation is stabilized by the Tikhonov regularization. Estimated values of the disturbing gravitational potential are compared with the same quantity synthesized directly from EGM2008. Finally, this contribution also discusses merging a regional solution into a global field as a patchwork.

Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox.

PubMed

Sminia, Tjerk J; Zuilhof, Han; Wennekes, Tom

2016-11-29

This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE. Copyright © 2016 Elsevier Ltd. All rights reserved.

An exploratory survey of noise levels associated with a 100kW wind turbine

NASA Technical Reports Server (NTRS)

Balombin, J. R.

1980-01-01

Noise measurements of a 125-foot diameter, 100 kW wind turbine are presented. The data include measurements as functions of distance from the turbine and directivity angle and cover a frequency range from 1 Hz to several kHz. Potential community impact is discussed in terms of A-weighted noise levels relative to background levels, and the intrasonic spectral content. Finally, the change in the sound power spectrum associated with a change in the rotor speed in described. The acoustic impact of this size wind turbine is judged to be minimal.

Solar energy

NASA Technical Reports Server (NTRS)

Rapp, D.

1981-01-01

The book opens with a review of the patterns of energy use and resources in the United States, and an exploration of the potential of solar energy to supply some of this energy in the future. This is followed by background material on solar geometry, solar intensities, flat plate collectors, and economics. Detailed attention is then given to a variety of solar units and systems, including domestic hot water systems, space heating systems, solar-assisted heat pumps, intermediate temperature collectors, space heating/cooling systems, concentrating collectors for high temperatures, storage systems, and solar total energy systems. Finally, rights to solar access are discussed.

Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.

PubMed

Zhang, Xuelin; Wang, Yang; Liu, Pingsheng

2017-01-01

Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.

Towards the development of universal, fast and highly accurate docking/scoring methods: a long way to go

PubMed Central

Moitessier, N; Englebienne, P; Lee, D; Lawandi, J; Corbeil, C R

2008-01-01

Accelerating the drug discovery process requires predictive computational protocols capable of reducing or simplifying the synthetic and/or combinatorial challenge. Docking-based virtual screening methods have been developed and successfully applied to a number of pharmaceutical targets. In this review, we first present the current status of docking and scoring methods, with exhaustive lists of these. We next discuss reported comparative studies, outlining criteria for their interpretation. In the final section, we describe some of the remaining developments that would potentially lead to a universally applicable docking/scoring method. PMID:18037925

HIV Infection in the Etiology of Lung Cancer

PubMed Central

Kirk, Gregory D.; Merlo, Christian A.

2011-01-01

Persons infected with HIV have an elevated risk of lung cancer, but whether the increase simply reflects a higher smoking prevalence continues to be debated. This review summarizes existing data on the association of HIV infection and lung cancer, with particular attention to study design and adjustment for cigarette smoking. Potential mechanisms by which HIV infection may lead to lung cancer are discussed. Finally, irrespective of causality and mechanisms, lung cancer represents an important and growing problem confronting HIV-infected patients and their providers. Substantial efforts are needed to promote smoking cessation and to control lung cancer among HIV-infected populations. PMID:21653536

The Multiple Carbohydrate Binding Specificities of Helicobacter pylori

NASA Astrophysics Data System (ADS)

Teneberg, Susann

Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed.

Natural Killer T Cells in Cancer Immunotherapy

PubMed Central

Nair, Shiny; Dhodapkar, Madhav V.

2017-01-01

Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future perspectives to better harness the potential of NKT cells for cancer therapy. PMID:29018445

Vectorization of Nucleic Acids for Therapeutic Approach: Tutorial Review.

PubMed

Geinguenaud, Frederic; Guenin, Erwann; Lalatonne, Yoann; Motte, Laurence

2016-05-20

Oligonucleotides present a high therapeutic potential for a wide variety of diseases. However, their clinical development is limited by their degradation by nucleases and their poor blood circulation time. Depending on the administration mode and the cellular target, these macromolecules will have to cross the vascular endothelium, to diffuse through the extracellular matrix, to be transported through the cell membrane, and finally to reach the cytoplasm. To overcome these physiological barriers, many strategies have been developed. Here, we review different methods of DNA vectorization, discuss limitations and advantages of the various vectors, and provide new perspectives for future development.

Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia

PubMed Central

Matsumoto, Rae R.; Seminerio, Michael J.; Turner, Ryan C.; Robson, Matthew J.; Nguyen, Linda; Miller, Diane B.; O’Callaghan, James P.

2015-01-01

Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine. PMID:24836729

Growth or decay of cosmological inhomogeneities as a function of their equation of state

NASA Astrophysics Data System (ADS)

Comer, G. L.; Deruelle, Nathalie; Langlois, David; Parry, Joe

1994-03-01

We expand Einstein's equations in the synchronous gauge in terms of a purely space-dependent, ``seed,'' metric. The (nonlinear) solution accurately describes a universe inhomogeneous at scales larger than the Hubble radius. We show that the inhomogeneities grow or decay, as time increases, depending on the equation of state for the matter (supposed to be a perfect fluid). We then consider the case when matter is a scalar field with an arbitrary potential. Finally we discuss the generality of the model and show that it is an attractor for a class of generic solutions of Einstein's equations.

Recent advances in electrospun nanofibers for wound healing.

PubMed

Chen, Shixuan; Liu, Bing; Carlson, Mark A; Gombart, Adrian F; Reilly, Debra A; Xie, Jingwei

2017-06-01

Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full-thickness skin regeneration. Finally, we finish with conclusions and future perspective in this field.

Biobehavioral Influences on Cancer Progression

PubMed Central

Costanzo, Erin S.; Sood, Anil K.; Lutgendorf, Susan K.

2010-01-01

Synopsis This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. We describe behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiological pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell-signaling pathways. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Finally, behavioral and pharmacological interventions for cancer patients with the potential to alter these biobehavioral pathways are discussed. PMID:21094927

Optical trapping performance of dielectric-metallic patchy particles

PubMed Central

Lawson, Joseph L.; Jenness, Nathan J.; Clark, Robert L.

2015-01-01

We demonstrate a series of simulation experiments examining the optical trapping behavior of composite micro-particles consisting of a small metallic patch on a spherical dielectric bead. A full parameter space of patch shapes, based on current state of the art manufacturing techniques, and optical properties of the metallic film stack is examined. Stable trapping locations and optical trap stiffness of these particles are determined based on the particle design and potential particle design optimizations are discussed. A final test is performed examining the ability to incorporate these composite particles with standard optical trap metrology technologies. PMID:26832054

Cross-Cultural Adaptation of a Text Message-Based Program for Smoking Cessation in Buenos Aires, Argentina.

PubMed

Colantonio, Lisandro D; Peña, Lorena; Whittaker, Robyn; Mejia, Raul M

2016-03-01

Few individual-level nonpharmacological interventions are available in Argentina to support smokers who attempt to quit. We conducted a cross-cultural adaptation of Stop Smoking with Mobile Phones, an English text message-based tobacco cessation program, in Buenos Aires. The process included English-Spanish translation and back-translation, face validity checking by two local tobacco cessation experts, and a complete review using a structured questionnaire and discussion groups with potential users (current smokers who want to quit or former smokers who quit in the past 6 months). An editing group was responsible for analyzing information collected and preparing adapted messages. Readability of final messages was assessed. Tobacco cessation experts found translated messages suitable for the local setting, although mention of "mate" (a local infusion which can trigger cravings) was recommended. Review of messages by two potential users confirmed most of the messages would help smokers to quit and resulted in minor edits. Potential users who participated in two discussion groups (n = 17, 64.7% female, age range: 30-73) found the content of messages was relevant for cessation and related to their own experiences, although they suggested adding information regarding the negative consequences of smoking. Participants emphasized that messages should be formatted using voseo and informal style and provided feedback on specific words and expressions. Readability of final messages was easy/very easy (Fernández Huerta Index: 79.93). The cross-cultural adaptation of Stop Smoking with Mobile Phones resulted in relevant revisions for the study population, including tone, wording, and pertinent information (eg, smoking consequences). Local acceptability and effectiveness should be confirmed in future studies. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

31 CFR Appendix A to Part 357 - Discussion of Final Rule

Code of Federal Regulations, 2011 CFR

2011-07-01

... as used in TRADES have been adopted. Section-By-Section Analysis Section 357.21Registration. The... final rules have adopted some of the existing practices applicable to commercial ACH payments, but it is... entities that are a part of the Government direct deposit network. See the discussion under paragraph (b)(2...

31 CFR Appendix A to Part 357 - Discussion of Final Rule

Code of Federal Regulations, 2013 CFR

2013-07-01

... as used in TRADES have been adopted. Section-By-Section Analysis Section 357.21Registration. The... final rules have adopted some of the existing practices applicable to commercial ACH payments, but it is... entities that are a part of the Government direct deposit network. See the discussion under paragraph (b)(2...

31 CFR Appendix A to Part 357 - Discussion of Final Rule

Code of Federal Regulations, 2012 CFR

2012-07-01

... as used in TRADES have been adopted. Section-By-Section Analysis Section 357.21Registration. The... final rules have adopted some of the existing practices applicable to commercial ACH payments, but it is... entities that are a part of the Government direct deposit network. See the discussion under paragraph (b)(2...

31 CFR Appendix A to Part 357 - Discussion of Final Rule

Code of Federal Regulations, 2014 CFR

2014-07-01

... as used in TRADES have been adopted. Section-By-Section Analysis Section 357.21Registration. The... final rules have adopted some of the existing practices applicable to commercial ACH payments, but it is... entities that are a part of the Government direct deposit network. See the discussion under paragraph (b)(2...

A pilot study of what African American maternal caregivers and their adolescent daughters talk about when asked to discuss tobacco together.

PubMed

Corona, Rosalie; Yaros, Anna; Pope, Michell; Velazquez, Efren; Augustin, Divinda

2016-01-01

Parents play a critical role in shaping their children's substance use behaviors, yet few studies have examined the messages that caregivers give their adolescents about tobacco. In this study, we identify tobacco-related messages discussed by African American maternal caregivers and their adolescent daughters. Twenty-five African American maternal caregivers and their adolescent daughters participated in a video-taped discussion about tobacco. Discussions were transcribed and coded thematically. Seven themes emerged, which were grouped into tobacco-messages and communication strategies. Messages included health risks, non-health-related reasons to stop smoking, reasons people smoke, and tobacco products and marijuana. Strategies caregivers used to communicate their tobacco-related messages included sharing personal or their families' experience with smoking, using humor, and role-playing. Finally, embedded within all of the themes, participants expressed their disapproval of tobacco use, whether it was directed at their own use, their adolescents' use, a family members' use, or peers' use. African American maternal caregivers and their daughters openly talk about a variety of tobacco-related topics, and caregivers are open to sharing their own and their families' experience with substance use. Findings also suggest that having caregivers and their adolescents participate in discussions tasks could be potentially beneficial in facilitating discussions and could identify areas in which caregivers could use help in discussing sensitive topics.

The Value of Native Plants and Local Production in an Era of Global Agriculture.

PubMed

Shelef, Oren; Weisberg, Peter J; Provenza, Frederick D

2017-01-01

For addressing potential food shortages, a fundamental tradeoff exists between investing more resources to increasing productivity of existing crops, as opposed to increasing crop diversity by incorporating more species. We explore ways to use local plants as food resources and the potential to promote food diversity and agricultural resilience. We discuss how use of local plants and the practice of local agriculture can contribute to ongoing adaptability in times of global change. Most food crops are now produced, transported, and consumed long distances from their homelands of origin. At the same time, research and practices are directed primarily at improving the productivity of a small number of existing crops that form the cornerstone of a global food economy, rather than to increasing crop diversity. The result is a loss of agro-biodiversity, leading to a food industry that is more susceptible to abiotic and biotic stressors, and more at risk of catastrophic losses. Humans cultivate only about 150 of an estimated 30,000 edible plant species worldwide, with only 30 plant species comprising the vast majority of our diets. To some extent, these practices explain the food disparity among human populations, where nearly 1 billion people suffer insufficient nutrition and 2 billion people are obese or overweight. Commercial uses of new crops and wild plants of local origin have the potential to diversify global food production and better enable local adaptation to the diverse environments humans inhabit. We discuss the advantages, obstacles, and risks of using local plants. We also describe a case study-the missed opportunity to produce pine nuts commercially in the Western United States. We discuss the potential consequences of using local pine nuts rather than importing them overseas. Finally, we provide a list of edible native plants, and synthesize the state of research concerning the potential and challenges in using them for food production. The goal of our synthesis is to support more local food production using native plants in an ecologically sustainable manner.

Neuroprediction, Violence, and the Law: Setting the Stage

PubMed Central

Bibas, Stephanos; Grafton, Scott; Kiehl, Kent A.; Mansfield, Andrew; Sinnott-Armstrong, Walter; Gazzaniga, Michael

2014-01-01

In this paper, our goal is to (a) survey some of the legal contexts within which violence risk assessment already plays a prominent role, (b) explore whether developments in neuroscience could potentially be used to improve our ability to predict violence, and (c) discuss whether neuropredictive models of violence create any unique legal or moral problems above and beyond the well worn problems already associated with prediction more generally. In “Violence Risk Assessment and the Law”, we briefly examine the role currently played by predictions of violence in three high stakes legal contexts: capital sentencing (“Violence Risk Assessment and Capital Sentencing”), civil commitment hearings (“Violence Risk Assessment and Civil Commitment”), and “sexual predator” statutes (“Violence Risk Assessment and Sexual Predator Statutes”). In “Clinical vs. Actuarial Violence Risk Assessment”, we briefly examine the distinction between traditional clinical methods of predicting violence and more recently developed actuarial methods, exemplified by the Classification of Violence Risk (COVR) software created by John Monahan and colleagues as part of the MacArthur Study of Mental Disorder and Violence [1]. In “The Neural Correlates of Psychopathy”, we explore what neuroscience currently tells us about the neural correlates of violence, using the recent neuroscientific research on psychopathy as our focus. We also discuss some recent advances in both data collection (“Cutting-Edge Data Collection: Genetically Informed Neuroimaging”) and data analysis (“Cutting-Edge Data Analysis: Pattern Classification”) that we believe will play an important role when it comes to future neuroscientific research on violence. In “The Potential Promise of Neuroprediction”, we discuss whether neuroscience could potentially be used to improve our ability to predict future violence. Finally, in “The Potential Perils of Neuroprediction”, we explore some potential evidentiary (“Evidentiary Issues”), constitutional (“Constitutional Issues”), and moral (“Moral Issues”) issues that may arise in the context of the neuroprediction of violence. PMID:25083168

Reusability aspects for space transportation rocket engines: programmatic status and outlook

NASA Astrophysics Data System (ADS)

Preclik, D.; Strunz, R.; Hagemann, G.; Langel, G.

2011-09-01

Rocket propulsion systems belong to the most critical subsystems of a space launch vehicle, being illustrated in this paper by comparing different types of transportation systems. The aspect of reusability is firstly discussed for the space shuttle main engine, the only rocket engine in the world that has demonstrated multiple reuses. Initial projections are contrasted against final reusability achievements summarizing three decades of operating the space shuttle main engine. The discussion is then extended to engines employed on expendable launch vehicles with an operational life requirement typically specifying structural integrities up to 20 cycles (start-ups) and an accumulated burning time of about 6,000 s (Vulcain engine family). Today, this life potential substantially exceeds the duty cycle of an expendable engine. It is actually exploited only during the development and qualification phase of an engine when system reliability is demonstrated on ground test facilities with a reduced number of hardware sets that are subjected to an extended number of test cycles and operation time. The paper will finally evaluate the logic and effort necessary to qualify a reusable engine for a required reliability and put this result in context of possible cost savings realized from reuse operations over a time span of 25 years.

Linking Metal Ions via Inorganic Click (iClick) Reactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veige, Adam

2015-11-17

This final report discusses the major objectives of the project, a discussion of the objectives achieved, a discussion of the objectives that failed, and finally, a discussion of future directions given the new knowledge obtained. This one-year seed project (with one year no-cost extension) contained three objectives: A) Expand the scope of iClick synthesis beyond AuI/AuI reactions. B) Elucidate a CuI-catalyzed iClick reaction. C) Synthesize and characterize tri- and tetra-metallic complexes as models for metallopolymers. Objectives A and C were achieved, whereas only parts of objective B were achieved.

Major clinical research advances in gynecologic cancer in 2013.

PubMed

Suh, Dong Hoon; Kim, Jae-Weon; Kang, Sokbom; Kim, Hak Jae; Lee, Kyung-Hun

2014-07-01

In 2013, 10 topics were selected for major clinical research advances in gynecologic oncology; these included three topics regarding cervical cancer, three regarding ovarian cancer, two regarding endometrial cancer, and one each regarding breast cancer and radiation oncology. For cervical cancer, bevacizumab was first demonstrated to exhibit outstanding clinical efficacy in a recurrent, metastatic setting. Regarding cervical cancer screening, visual inspections with acetic acid in low-resource settings, p16/Ki-67 double staining, and the follow-up results of four randomized controlled trials of human papillomavirus-based screening methods were reviewed. Laparoscopic para-aortic lymphadenectomy before chemoradiation for locally advanced cervical cancer was the final topic for cervical cancer. Regarding front-line ovarian cancer therapies, dose-dense paclitaxel and carboplatin, intraperitoneal chemotherapy, and other targeted agents administered according to combination or maintenance schedules were discussed. Regarding recurrent ovarian cancer treatment, cediranib, olaparib, and farletuzumab were discussed for platinum-sensitive disease. The final overall survival data associated with a combination of bevacizumab and chemotherapy for platinum-resistant disease were briefly summarized. For endometrial cancer, the potential clinical efficacy of metformin, an antidiabetic drug, in obese patients was followed by integrated genomic analyses from the Cancer Genome Atlas Research Network. For breast cancer, three remarkable advances were reviewed: the long-term effects of continued adjuvant tamoxifen for 10 years, the effects of 2-year versus 1-year adjuvant trastuzumab for human epidermal growth factor receptor 2-positive disease, and the approval of pertuzumab in a neoadjuvant setting with a pathologic complete response as the surrogate endpoint. Finally, the recent large studies of intensity-modulated radiotherapy for gynecologic cancer were briefly summarized.

75 FR 73169 - Medicare Program; Payment Policies Under the Physician Fee Schedule and Other Revisions to Part B...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

...This final rule with comment period addresses changes to the physician fee schedule and other Medicare Part B payment policies to ensure that our payment systems are updated to reflect changes in medical practice and the relative value of services. It finalizes the calendar year (CY) 2010 interim relative value units (RVUs) and issues interim RVUs for new and revised procedure codes for CY 2011. It also addresses, implements, or discusses certain provisions of both the Affordable Care Act (ACA) and the Medicare Improvements for Patients and Providers Act of 2008 (MIPPA). In addition, this final rule with comment period discusses payments under the Ambulance Fee Schedule (AFS), the Ambulatory Surgical Center (ASC) payment system, and the Clinical Laboratory Fee Schedule (CLFS), payments to end-stage renal disease (ESRD) facilities, and payments for Part B drugs. Finally, this final rule with comment period also includes a discussion regarding the Chiropractic Services Demonstration program, the Competitive Bidding Program for durable medical equipment, prosthetics, orthotics, and supplies (CBP DMEPOS), and provider and supplier enrollment issues associated with air ambulances.

Use It or Lose It: Advances in Our Understanding of Terrestrial Nitrogen Retention and Loss (Invited)

NASA Astrophysics Data System (ADS)

Silver, W. L.; Yang, W. H.

2013-12-01

Understanding of the terrestrial nitrogen (N) cycle has grown over the last decade to include a variety of pathways that have the potential to either retain N in the ecosystem or result in losses to the atmosphere or groundwater. Early work has described the mechanics of these N transformations, but the relevance of these processes to ecosystem, regional, or global scale N cycling has not been well quantified. In this study, we review advances in our understanding of the terrestrial N cycle, and focus on three pathways with particular relevance to N retention and loss: dissimilatory nitrate and nitrite reduction to ammonium (DNRA), anaerobic ammonium oxidation (annamox), and anaerobic ammonium oxidation coupled to iron reduction (Feammox). We discuss the role of these processes in the microbial N economy (sensu Burgin et al. 2011) of the terrestrial N cycle, the environmental and ecological constraints, and relationships with other key biogeochemical cycles. We also discuss recent advances in analytical approaches that have improved our ability to detect these and related N fluxes in terrestrial ecosystems. Finally, we present a scaling exercise that identifies the potential importance of these pathways for N retention and loss across a range of spatial and temporal scales, and discuss their significance in terms of N limitation to net primary productivity, N leaching to groundwater, and the release of reactive N gases to the atmosphere.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roldan, Omar; Quartin, Miguel; Notari, Alessio, E-mail: oaroldan@if.ufrj.br, E-mail: notari@ffn.ub.es, E-mail: mquartin@if.ufrj.br

The aberration and Doppler coupling effects of the Cosmic Microwave Background (CMB) were recently measured by the Planck satellite. The most straightforward interpretation leads to a direct detection of our peculiar velocity β, consistent with the measurement of the well-known dipole. In this paper we discuss the assumptions behind such interpretation. We show that Doppler-like couplings appear from two effects: our peculiar velocity and a second order large-scale effect due to the dipolar part of the gravitational potential. We find that the two effects are exactly degenerate but only if we assume second-order initial conditions from single-field Inflation. Thus, detectingmore » a discrepancy in the value of β from the dipole and the Doppler couplings implies the presence of a primordial non-Gaussianity. We also show that aberration-like signals likewise arise from two independent effects: our peculiar velocity and lensing due to a first order large-scale dipolar gravitational potential, independently on Gaussianity of the initial conditions. In general such effects are not degenerate and so a discrepancy between the measured β from the dipole and aberration could be accounted for by a dipolar gravitational potential. Only through a fine-tuning of the radial profile of the potential it is possible to have a complete degeneracy with a boost effect. Finally we discuss that we also expect other signatures due to integrated second order terms, which may be further used to disentangle this scenario from a simple boost.« less

Anabolic effects of IGF-1 signaling on the skeleton

PubMed Central

Tahimic, Candice G. T.; Wang, Yongmei; Bikle, Daniel D.

2013-01-01

This review focuses on the anabolic effects of IGF-1 signaling on the skeleton, emphasizing the requirement for IGF-1 signaling in normal bone formation and remodeling. We first discuss the genomic context, splicing variants, and species conservation of the IGF-1 locus. The modulation of IGF-1 action by growth hormone (GH) is then reviewed while also discussing the current model which takes into account the GH-independent actions of IGF-1. Next, the skeletal phenotypes of IGF-1-deficient animals are described in both embryonic and postnatal stages of development, which include severe dwarfism and an undermineralized skeleton. We then highlight two mechanisms by which IGF-1 exerts its anabolic action on the skeleton. Firstly, the role of IGF-1 signaling in the modulation of anabolic effects of parathyroid hormone (PTH) on bone will be discussed, presenting in vitro and in vivo studies that establish this concept and the proposed underlying molecular mechanisms involving Indian hedgehog (Ihh) and the ephrins. Secondly, the crosstalk of IGF-1 signaling with mechanosensing pathways will be discussed, beginning with the observation that animals subjected to skeletal unloading by hindlimb elevation are unable to mitigate cessation of bone growth despite infusion with IGF-1 and the failure of IGF-1 to activate its receptor in bone marrow stromal cell cultures from unloaded bone. Disrupted crosstalk between IGF-1 signaling and the integrin mechanotransduction pathways is discussed as one of the potential mechanisms for this IGF-1 resistance. Next, emerging paradigms on bone-muscle crosstalk are examined, focusing on the potential role of IGF-1 signaling in modulating such interactions. Finally, we present a future outlook on IGF research. PMID:23382729

Grid today, clouds on the horizon

NASA Astrophysics Data System (ADS)

Shiers, Jamie

2009-04-01

By the time of CCP 2008, the largest scientific machine in the world - the Large Hadron Collider - had been cooled down as scheduled to its operational temperature of below 2 degrees Kelvin and injection tests were starting. Collisions of proton beams at 5+5 TeV were expected within one to two months of the initial tests, with data taking at design energy ( 7+7 TeV) foreseen for 2009. In order to process the data from this world machine, we have put our "Higgs in one basket" - that of Grid computing [The Worldwide LHC Computing Grid (WLCG), in: Proceedings of the Conference on Computational Physics 2006 (CCP 2006), vol. 177, 2007, pp. 219-223]. After many years of preparation, 2008 saw a final "Common Computing Readiness Challenge" (CCRC'08) - aimed at demonstrating full readiness for 2008 data taking, processing and analysis. By definition, this relied on a world-wide production Grid infrastructure. But change - as always - is on the horizon. The current funding model for Grids - which in Europe has been through 3 generations of EGEE projects, together with related projects in other parts of the world, including South America - is evolving towards a long-term, sustainable e-infrastructure, like the European Grid Initiative (EGI) [The European Grid Initiative Design Study, website at http://web.eu-egi.eu/]. At the same time, potentially new paradigms, such as that of "Cloud Computing" are emerging. This paper summarizes the results of CCRC'08 and discusses the potential impact of future Grid funding on both regional and international application communities. It contrasts Grid and Cloud computing models from both technical and sociological points of view. Finally, it discusses the requirements from production application communities, in terms of stability and continuity in the medium to long term.

Improving outcomes of hospitalized patients: the Physician Relationships, Improvising, and Sensemaking intervention protocol.

PubMed

Leykum, Luci K; Lanham, Holly J; Provost, Shannon M; McDaniel, Reuben R; Pugh, Jacqueline

2014-11-26

Our goal is to improve the safety and effectiveness of inpatient care. Rather than focus on improving process of care, we focus on the social structure within physician teams. We have developed the Physician Relationships, Improvising, and Sensemaking (PRISm) intervention to improve the way physician teams round, enabling them to better relate, make sense of their patients' conditions, and improvise in uncertain clinical situations. We are currently studying the impact of PRISm on adverse events and complications in hospitalized patients. This manuscript describes the PRISm intervention. PRISm is a structured communication tool consisting of three components: daily briefings before rounds; use of the Situation, Task, Intent, Concern, and Calibrate (STICC) framework during rounds as part of the discussion of individual patients; and debriefings after rounds. We are implementing the PRISm intervention on eight inpatient medical and surgical physician teams in the South Texas Veterans Health Care System. We are assessing PRISm impact on the way team members relate to each other, round, and discuss patients through pre- and post-implementation observations and surveys. We are also assessing PRISm impact on complications and adverse events. Finally, we are interviewing physicians regarding their experience using the intervention. Our results will allow us to begin to understand the potential impact of interventions designed to improve how providers relate to each other, improvise, and make sense of what is happening as a strategy for improving inpatient care. Our in-depth data collection will enable us to assess how relationships, improvising, and sensemaking influence patient outcomes, potentially through creating shared mental models or enhancing distributed cognition during clinical reasoning. Finally, our results will lay the groundwork for larger implementation studies to improve clinical outcomes through improving how providers, and providers, patients, and caregivers, relate.

29 CFR 1990.147 - Final action.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS Regulation of Potential Occupational Carcinogens § 1990.147 Final action. (a) Within one hundred twenty (120) days from the last day of... is classified as a Category I Potential Carcinogen or as a Category II Potential Carcinogen. If the...

29 CFR 1990.147 - Final action.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS Regulation of Potential Occupational Carcinogens § 1990.147 Final action. (a) Within one hundred twenty (120) days from the last day of... is classified as a Category I Potential Carcinogen or as a Category II Potential Carcinogen. If the...

29 CFR 1990.147 - Final action.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS Regulation of Potential Occupational Carcinogens § 1990.147 Final action. (a) Within one hundred twenty (120) days from the last day of... is classified as a Category I Potential Carcinogen or as a Category II Potential Carcinogen. If the...

29 CFR 1990.147 - Final action.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS Regulation of Potential Occupational Carcinogens § 1990.147 Final action. (a) Within one hundred twenty (120) days from the last day of... is classified as a Category I Potential Carcinogen or as a Category II Potential Carcinogen. If the...

Nuclear Dynamics at Molecule–Metal Interfaces: A Pseudoparticle Perspective

DOE PAGES

Galperin, Michael; Nitzan, Abraham

2015-11-20

We discuss nuclear dynamics at molecule-metal interfaces including nonequilibrium molecular junctions. Starting from the many-body states (pseudoparticle) formulation of the molecule-metal system in the molecular vibronic basis, we introduce gradient expansion to reduce the adiabatic nuclear dynamics (that is, nuclear dynamics on a single molecular potential surface) into its semiclassical form while maintaining the effect of the nonadiabatic electronic transitions between different molecular charge states. Finally, this yields a set of equations for the nuclear dynamics in the presence of these nonadiabatic transitions, which reproduce the surface-hopping formulation in the limit of small metal-molecule coupling (where broadening of the molecularmore » energy levels can be disregarded) and Ehrenfest dynamics (motion on the potential of mean force) when information on the different charging states is traced out.« less

Unsolicited E-mails to Forensic Psychiatrists.

PubMed

Friedman, Susan Hatters; Appel, Jacob M; Ash, Peter; Frierson, Richard L; Giorgi-Guarnieri, Deborah; Martinez, Richard; Newman, Alan W; Pinals, Debra A; Resnick, Phillip J; Simpson, Alexander I F

2016-12-01

E-mail communication is pervasive. Since many forensic psychiatrists have their e-mail addresses available online (either on personal websites, university websites, or articles they have authored), they are likely to receive unsolicited e-mails. Although there is an emerging body of literature about exchanging e-mail with patients, there is little guidance about how to respond to e-mails from nonpatients. Therefore, we used a Delphi technique to develop a consensus about salient points for the forensic psychiatrist to consider regarding responding to e-mails from nonpatients and the risks entailed. Four scenarios are described, including e-mails from nonpatients and unknown others requesting advice or help. The potential ethics-related, legal, moral, and practical concerns for forensic psychiatrists are discussed. Finally, potential pitfalls for forensic psychiatrists are described. © 2016 American Academy of Psychiatry and the Law.

Innovation in Bladder Cancer Immunotherapy.

PubMed

Grossman, H Barton; Lamm, Donald L; Kamat, Ashish M; Keefe, Stephen; Taylor, John A; Ingersoll, Molly A

2016-10-01

Bladder cancer is understudied despite its high prevalence and its remarkable response to immunotherapy. Indeed, funding for studies to explore mechanisms of tumor immunity and novel new therapeutics is disproportionately lower for bladder cancer in comparison with malignancies of the breast, prostate, or lung. However, the recent successes of checkpoint blockade therapy suggest that new therapeutic strategies are on the horizon for bladder cancer. Here, we give a perspective into the evolution of bladder cancer therapy, focusing on strategies to treat high-risk nonmuscle invasive disease, followed by a discussion of recent advances in the treatment of muscle invasive bladder cancer and their potential applicability to lower stage disease. Finally, we explore immunotherapeutic strategies, which have been demonstrated to be successful in the treatment of other malignancies, for their potential to treat and cure patients with nonmuscle and muscle invasive bladder cancer.

Water on Mars: Inventory, distribution, and possible sources of polar ice

NASA Technical Reports Server (NTRS)

Clifford, S. M.

1992-01-01

Theoretical considerations and various lines of morphologic evidence suggest that, in addition to the normal seasonal and climatic exchange of H2O that occurs between the Martian polar caps, atmosphere, and mid to high latitude regolith, large volumes of water have been introduced into the planet's long term hydrologic cycle by the sublimation of equatorial ground ice, impacts, catastrophic flooding, and volcanism. Under the climatic conditions that are thought to have prevailed on Mars throughout the past 3 to 4 b.y., much of this water is expected to have been cold trapped at the poles. The amount of polar ice contributed by each of the planet's potential crustal sources is discussed and estimated. The final analysis suggests that only 5 to 15 pct. of this potential inventory is now in residence at the poles.

Time is of the Essence: A Review of Electroencephalography (EEG) and Event-Related Brain Potentials (ERPs) in Language Research.

PubMed

Beres, Anna M

2017-12-01

The discovery of electroencephalography (EEG) over a century ago has changed the way we understand brain structure and function, in terms of both clinical and research applications. This paper starts with a short description of EEG and then focuses on the event-related brain potentials (ERPs), and their use in experimental settings. It describes the typical set-up of an ERP experiment. A description of a number of ERP components typically involved in language research is presented. Finally, the advantages and disadvantages of using ERPs in language research are discussed. EEG has an extensive use in today's world, including medical, psychology, or linguistic research. The excellent temporal resolution of EEG information allows one to track a brain response in milliseconds and therefore makes it uniquely suited to research concerning language processing.

Continuum limbed robots for locomotion

NASA Astrophysics Data System (ADS)

Mutlu, Alper

This thesis focuses on continuum robots based on pneumatic muscle technology. We introduce a novel approach to use these muscles as limbs of lightweight legged robots. The flexibility of the continuum legs of these robots offers the potential to perform some duties that are not possible with classical rigid-link robots. Potential applications are as space robots in low gravity, and as cave explorer robots. The thesis covers the fabrication process of continuum pneumatic muscles and limbs. It also provides some new experimental data on this technology. Afterwards, the designs of two different novel continuum robots - one tripod, one quadruped - are introduced. Experimental data from tests using the robots is provided. The experimental results are the first published example of locomotion with tripod and quadruped continuum legged robots. Finally, discussion of the results and how far this technology can go forward is presented.

Pigmentation in Xiphophorus: an emerging system in ecological and evolutionary genetics.

PubMed

Culumber, Zachary W

2014-02-01

The genus Xiphophorus has great potential to contribute to the study of vertebrate pigmentation and elucidating the relative influence of ecology, physiology, and behavior on evolution at the molecular level. More importantly, the association between pigmentation and a functional oncogene offers the potential to understand the evolution and maintenance of cancer-causing genetic elements. Using criteria laid out recently in the literature, I demonstrate the power of the Xiphophorus system for studying pigment evolution through integrative organismal biology. Using the most recent phylogeny, the phylogenetic distribution of several important pigmentation loci are reevaluated. I then review support for existing hypotheses of the functional importance of pigmentation. Finally, new observations and hypotheses regarding some of the characteristics of pigment patterns in natural populations and open questions and future directions in the study of the evolution of these traits are discussed.

An overview of LED applications for general illumination

NASA Astrophysics Data System (ADS)

Pelka, David G.; Patel, Kavita

2003-11-01

This paper begins by reviewing the current state of development of LEDs, their existing markets as well as their potential for energy conservation and their potential for gaining market share in the general illumination market. It discusses LED metrics such as chip size, lumens per watt, thermal resistance, and the recommended maximum current rating. The paper then goes on to consider the importance of non-imaging optics for both optically efficient and extremely compact LED lighting systems. Finally, microstructures useful for controlling the fields-of-view of LED lighting systems are considered and described in some detail. An extremely efficient and cost effective microstructure, called kinoform diffusers, is shown to have very unique properties that make this technology almost ideal for shaping the output beams of LED lighting systems. It concludes by illustrating some general illumination LED lighting systems

Sulfonamides as Inhibitors of Leishmania – Potential New Treatments for Leishmaniasis

PubMed Central

Katinas, Jade; Epplin, Rachel; Hamaker, Christopher; Jones, Marjorie A.

2017-01-01

Introduction: Leishmaniasis is an endemic disease caused by the protozoan parasite Leishmania. Current treatments for the parasite are limited by cost, availability and drug resistance as the occurrence of leishmaniasis continues to be more prevalent. Sulfonamides are a class of compounds with medicinal properties which have been used to treat bacterial and parasitic disease via various pathways especially as antimetabolites for folic acid. Methods: New derivatives of sulfonamide compounds were assessed for their impact on Leishmania cell viability and potential pathways for inhibition were evaluated. Leishmania tarentolae (ATCC Strain 30143) axenic promastigote cells were grown in brain heart infusion (BHI) medium and treated with varying concentrations of the new sulfonamide compounds. Light microscopy and viability tests were used to assess the cells with and without treatment. Discussion: A non-water soluble sulfonamide was determined to have 90-96% viability inhibition 24 hours after treatment with 100 µM final concentration. Because Leishmania are also autotrophs for folate precursors, the folic acid pathway was identified as a target for sulfonamide inhibition. When folic acid was added to untreated Leishmania, cell proliferation increased. A water soluble derivative of the inhibitory sulfonamide was synthesized and evaluated, resulting in less viability inhibition with a single dose (approximately 70% viability inhibition after 24 hours with 100 µM final concentration), but additive inhibition with multiple doses of the compound. Results: However, the potential mechanism of inhibition was different between the water-soluble and non-water soluble sulfonamides. The inhibitory effects and potential pathways of inhibition indicate that these compounds may be new treatments for this disease. PMID:29399442

Automatic micropropagation of plants

NASA Astrophysics Data System (ADS)

Otte, Clemens; Schwanke, Joerg; Jensch, Peter F.

1996-12-01

Micropropagation is a sophisticated technique for the rapid multiplication of plants. It has a great commercial potential due to the speed of propagation, the high plant quality, and the ability to produce disease-free plants. However, micropropagation is usually done by hand which makes the process cost-intensive and tedious for the workers especially because it requires a sterile work-place. Therefore, we have developed a prototype automation system for the micropropagation of a grass species (miscanthus sinensis gigantheus). The objective of this paper is to describe the robotic system in an overview and to discuss the vision system more closely including the implemented morphological operations recognizing the cutting and gripping points of miscanthus plants. Fuzzy controllers are used to adapt the parameters of image operations on-line to each individual plant. Finally, we discuss our experiences with the developed prototype an give a preview of a possible real production line system.

Analysis and optimization of preliminary aircraft configurations in relationship to emerging agility metrics

NASA Technical Reports Server (NTRS)

Sandlin, Doral R.; Bauer, Brent Alan

1993-01-01

This paper discusses the development of a FORTRAN computer code to perform agility analysis on aircraft configurations. This code is to be part of the NASA-Ames ACSYNT (AirCraft SYNThesis) design code. This paper begins with a discussion of contemporary agility research in the aircraft industry and a survey of a few agility metrics. The methodology, techniques and models developed for the code are then presented. Finally, example trade studies using the agility module along with ACSYNT are illustrated. These trade studies were conducted using a Northrop F-20 Tigershark aircraft model. The studies show that the agility module is effective in analyzing the influence of common parameters such as thrust-to-weight ratio and wing loading on agility criteria. The module can compare the agility potential between different configurations. In addition one study illustrates the module's ability to optimize a configuration's agility performance.

Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy

PubMed Central

Whitmore, S.Scott; Sohn, Elliott H.; Chirco, Kathleen R.; Drack, Arlene V.; Stone, Edwin M.; Tucker, Budd A.; Mullins, Robert F.

2015-01-01

Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies. PMID:25486088

Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

PubMed

Whitmore, S Scott; Sohn, Elliott H; Chirco, Kathleen R; Drack, Arlene V; Stone, Edwin M; Tucker, Budd A; Mullins, Robert F

2015-03-01

Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies. Copyright © 2014 Elsevier Ltd. All rights reserved.

Progress in the development and integration of fluid flow control tools in paper microfluidics.

PubMed

Fu, Elain; Downs, Corey

2017-02-14

Paper microfluidics is a rapidly growing subfield of microfluidics in which paper-like porous materials are used to create analytical devices. There is a need for higher performance field-use tests for many application domains including human disease diagnosis, environmental monitoring, and veterinary medicine. A key factor in creating high performance paper-based devices is the ability to manipulate fluid flow within the devices. This critical review is focused on the progress that has been made in (i) the development of fluid flow control tools and (ii) the integration of those tools into paper microfluidic devices. Further, we strive to be comprehensive in our presentation and provide historical context through discussion and performance comparisons, when possible, of both relevant earlier work and recent work. Finally, we discuss the major areas of focus for fluid flow methods development to advance the potential of paper microfluidics for high-performance field applications.

Adaptive focus for deep tissue using diffuse backscatter

NASA Astrophysics Data System (ADS)

Kress, Jeremy; Pourrezaei, Kambiz

2014-02-01

A system integrating high density diffuse optical imaging with adaptive optics using MEMS for deep tissue interaction is presented. In this system, a laser source is scanned over a high density fiber bundle using Digital Micromirror Device (DMD) and channeled to a tissue phantom. Backscatter is then collected from the tissue phantom by a high density fiber array of different fiber type and channeled to CMOS sensor for image acquisition. Intensity focus is directly verified using a second CMOS sensor which measures intensity transmitted though the tissue phantom. A set of training patterns are displayed on the DMD and backscatter is numerically fit to the transmission intensity. After the training patterns are displayed, adaptive focus is performed using only the backscatter and fitting functions. Additionally, tissue reconstruction and prediction of interference focusing by photoacoustic and optical tomographic methods is discussed. Finally, potential NIR applications such as in-vivo adaptive neural photostimulation and cancer targeting are discussed.

Development of a Computer Program for Analyzing Preliminary Aircraft Configurations in Relationship to Emerging Agility Metrics

NASA Technical Reports Server (NTRS)

Bauer, Brent

1993-01-01

This paper discusses the development of a FORTRAN computer code to perform agility analysis on aircraft configurations. This code is to be part of the NASA-Ames ACSYNT (AirCraft SYNThesis) design code. This paper begins with a discussion of contemporary agility research in the aircraft industry and a survey of a few agility metrics. The methodology, techniques and models developed for the code are then presented. Finally, example trade studies using the agility module along with ACSYNT are illustrated. These trade studies were conducted using a Northrop F-20 Tigershark aircraft model. The studies show that the agility module is effective in analyzing the influence of common parameters such as thrust-to-weight ratio and wing loading on agility criteria. The module can compare the agility potential between different configurations. In addition, one study illustrates the module's ability to optimize a configuration's agility performance.

Using Noninvasive Wearable Computers to Recognize Human Emotions from Physiological Signals

NASA Astrophysics Data System (ADS)

Lisetti, Christine Lætitia; Nasoz, Fatma

2004-12-01

We discuss the strong relationship between affect and cognition and the importance of emotions in multimodal human computer interaction (HCI) and user modeling. We introduce the overall paradigm for our multimodal system that aims at recognizing its users' emotions and at responding to them accordingly depending upon the current context or application. We then describe the design of the emotion elicitation experiment we conducted by collecting, via wearable computers, physiological signals from the autonomic nervous system (galvanic skin response, heart rate, temperature) and mapping them to certain emotions (sadness, anger, fear, surprise, frustration, and amusement). We show the results of three different supervised learning algorithms that categorize these collected signals in terms of emotions, and generalize their learning to recognize emotions from new collections of signals. We finally discuss possible broader impact and potential applications of emotion recognition for multimodal intelligent systems.

Oral vaccination of fish: Lessons from humans and veterinary species.

PubMed

Embregts, Carmen W E; Forlenza, Maria

2016-11-01

The limited number of oral vaccines currently approved for use in humans and veterinary species clearly illustrates that development of efficacious and safe oral vaccines has been a challenge not only for fish immunologists. The insufficient efficacy of oral vaccines is partly due to antigen breakdown in the harsh gastric environment, but also to the high tolerogenic gut environment and to inadequate vaccine design. In this review we discuss current approaches used to develop oral vaccines for mass vaccination of farmed fish species. Furthermore, using various examples from the human and veterinary vaccine development, we propose additional approaches to fish vaccine design also considering recent advances in fish mucosal immunology and novel molecular tools. Finally, we discuss the pros and cons of using the zebrafish as a pre-screening animal model to potentially speed up vaccine design and testing for aquaculture fish species. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Environmental review of the Panda-Brandywine cogeneration project. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walters, G.; Keating, R.; Huggins, A.

1997-02-01

The Maryland Public Service Commission (PSC) granted a Certificate of Public Convenience and Necessity (CPCN) to Panda-Brandywine, L.P., to construct and operate a 248-megawatt (electric) generating station near Brandywine, Prince George`s County, Maryland. This report describes PPRP`s evaluation of the environmental and socioeconomic impacts of the Panda-Brandywine facility, summarizes the results of that evaluation, and presents recommendations for license conditions which have been incorporated into Panda`s CPCN. The document includes description of the proposed facility, host facility, and associated linear facilities (transmission line, pipelines); discussion of existing environmental and socioeconomic conditions at the site and in the vicinity; analysis ofmore » the potential air quality, surface water, biological, ground water, socioeconomic, cultural, and noise impacts from the proposed facility; and discussion of critical engineering issues associated with operation of the facility, including water supply, water discharge, and fuel handling.« less

BaTiO3-based piezoelectrics: Fundamentals, current status, and perspectives

NASA Astrophysics Data System (ADS)

Acosta, M.; Novak, N.; Rojas, V.; Patel, S.; Vaish, R.; Koruza, J.; Rossetti, G. A.; Rödel, J.

2017-12-01

We present a critical review that encompasses the fundamentals and state-of-the-art knowledge of barium titanate-based piezoelectrics. First, the essential crystallography, thermodynamic relations, and concepts necessary to understand piezoelectricity and ferroelectricity in barium titanate are discussed. Strategies to optimize piezoelectric properties through microstructure control and chemical modification are also introduced. Thereafter, we systematically review the synthesis, microstructure, and phase diagrams of barium titanate-based piezoelectrics and provide a detailed compilation of their functional and mechanical properties. The most salient materials treated include the (Ba,Ca)(Zr,Ti)O3, (Ba,Ca)(Sn,Ti)O3, and (Ba,Ca)(Hf,Ti)O3 solid solution systems. The technological relevance of barium titanate-based piezoelectrics is also discussed and some potential market indicators are outlined. Finally, perspectives on productive lines of future research and promising areas for the applications of these materials are presented.

Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

PubMed Central

Melki, Ronald

2015-01-01

Abstract Misfolded protein aggregates are the hallmark of several neurodegenerative diseases in humans. The main protein constituent of these aggregates and the regions within the brain that are affected differ from one neurodegenerative disorder to another. A plethora of reports suggest that distinct diseases have in common the ability of protein aggregates to spread and amplify within the central nervous system. This review summarizes briefly what is known about the nature of the protein aggregates that are infectious and the reason they are toxic to cells. The chameleon property of polypeptides which aggregation into distinct high-molecular weight assemblies is associated to different diseases, in particular, that of alpha-synuclein which aggregation is the hallmark of distinct synucleinopathies, is discussed. Finally, strategies targeting the formation and propagation of structurally distinct alpha-synuclein assemblies associated to different synucleinopathies are presented and their therapeutic and diagnostic potential is discussed. PMID:25757830

L1 retrotransposons and somatic mosaicism in the brain.

PubMed

Richardson, Sandra R; Morell, Santiago; Faulkner, Geoffrey J

2014-01-01

Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third of the human genome, and their ongoing mobility is a source of inter- and intraindividual genetic diversity. Although retrotransposition in metazoans has long been considered a germline phenomenon, recent experiments using cultured cells, animal models, and human tissues have revealed extensive L1 mobilization in rodent and human neurons, as well as mobile element activity in the Drosophila brain. In this review, we evaluate the available evidence for L1 retrotransposition in the brain and discuss mechanisms that may regulate neuronal retrotransposition in vivo. We compare experimental strategies used to map de novo somatic retrotransposition events and present the optimal criteria to identify a somatic L1 insertion. Finally, we discuss the unresolved impact of L1-mediated somatic mosaicism upon normal neurobiology, as well as its potential to drive neurological disease.

Advances in Robotic, Human, and Autonomous Systems for Missions of Space Exploration

NASA Technical Reports Server (NTRS)

Gross, Anthony R.; Briggs, Geoffrey A.; Glass, Brian J.; Pedersen, Liam; Kortenkamp, David M.; Wettergreen, David S.; Nourbakhsh, I.; Clancy, Daniel J.; Zornetzer, Steven (Technical Monitor)

2002-01-01

Space exploration missions are evolving toward more complex architectures involving more capable robotic systems, new levels of human and robotic interaction, and increasingly autonomous systems. How this evolving mix of advanced capabilities will be utilized in the design of new missions is a subject of much current interest. Cost and risk constraints also play a key role in the development of new missions, resulting in a complex interplay of a broad range of factors in the mission development and planning of new missions. This paper will discuss how human, robotic, and autonomous systems could be used in advanced space exploration missions. In particular, a recently completed survey of the state of the art and the potential future of robotic systems, as well as new experiments utilizing human and robotic approaches will be described. Finally, there will be a discussion of how best to utilize these various approaches for meeting space exploration goals.

Brain mechanisms of social comparison and their influence on the reward system.

PubMed

Kedia, Gayannée; Mussweiler, Thomas; Linden, David E J

2014-11-12

Whenever we interact with others, we judge them and whenever we make such judgments, we compare them with ourselves, other people, or internalized standards. Countless social psychological experiments have shown that comparative thinking plays a ubiquitous role in person perception and social cognition as a whole. The topic of social comparison has recently aroused the interest of social neuroscientists, who have begun to investigate its neural underpinnings. The present article provides an overview of these neuroimaging and electrophysiological studies. We discuss recent findings on the consequences of social comparison on the brain processing of outcomes and highlight the role of the brain's reward system. Moreover, we analyze the relationship between the brain networks involved in social comparisons and those active during other forms of cognitive and perceptual comparison. Finally, we discuss potential future questions that research on the neural correlates of social comparison could address.

Stabilization of food dispersions by enzymes.

PubMed

Zeeb, Benjamin; Fischer, Lutz; Weiss, Jochen

2014-02-01

Food dispersions have become essential vehicles to carry and deliver functional ingredients such as bioactive compounds, flavors, antimicrobials, antioxidants, colors and vitamins. Most of these systems are thermodynamically unstable tending to break down over time. Much research has therefore been carried out to develop methodologies to improve their long-term stability. In this review, we will introduce readers to a new approach that has been developed over the past years to stabilize food dispersions, i.e. by use of various enzymes. First, basic design principles of modern food dispersions including conventional emulsions, multiple emulsions, multilayered emulsions, solid lipid particle suspensions, and liposomes are discussed. Enzymes able to generate intra- and intermolecular crosslinks between proteins and/or polysaccharides will be reviewed and specific reactions catalyzed by, e.g., transglutaminase, laccase, tyrosinase, sulfhydryl oxidase, glucose oxidase, lipoxygenase, polyphenol oxidase, peroxidase, and lysyl oxidase will be highlighted. Finally, potential applications of this enzymatic approach in the food industry will be critically discussed.

Engineering chemical interactions in microbial communities.

PubMed

Kenny, Douglas J; Balskus, Emily P

2018-03-05

Microbes living within host-associated microbial communities (microbiotas) rely on chemical communication to interact with surrounding organisms. These interactions serve many purposes, from supplying the multicellular host with nutrients to antagonizing invading pathogens, and breakdown of chemical signaling has potentially negative consequences for both the host and microbiota. Efforts to engineer microbes to take part in chemical interactions represent a promising strategy for modulating chemical signaling within these complex communities. In this review, we discuss prominent examples of chemical interactions found within host-associated microbial communities, with an emphasis on the plant-root microbiota and the intestinal microbiota of animals. We then highlight how an understanding of such interactions has guided efforts to engineer microbes to participate in chemical signaling in these habitats. We discuss engineering efforts in the context of chemical interactions that enable host colonization, promote host health, and exclude pathogens. Finally, we describe prominent challenges facing this field and propose new directions for future engineering efforts.

The development of scientific evidence for health policies for obesity: why and how

PubMed Central

Richardson, Molly B.; Williams, Michelle S.; Fontaine, Kevin R.; Allison, David B.

2017-01-01

Potential obesity-related policy approaches have recently been receiving more attention. While some have been implemented and others only proposed, few have been formally evaluated. We discuss the relevance, and in some cases irrelevance, of some of the types of evidence that are often brought to bear in considering obesity-related policy decisions. We discuss major methods used to generate such evidence, emphasizing study design and the varying quality of the evidence obtained. Third, we consider what the standards of evidence should be in various contexts, who ought to set those standards, as well as the inherent subjectivity involved in making policy decisions. Finally, we suggest greater transparency from both academics and policymakers in the acknowledgment of subjectivities so they can distinguish and communicate the roles played by empirical evidence and subjective values in the formulation of policy. PMID:28293021

Pediatric Issues in Return of Results and Incidental Findings: Weighing Autonomy and Best Interests.

PubMed

Holm, Ingrid A

2017-03-01

Nowhere are the ethical issues in genomic research more complex than in pediatrics. Balancing the sometime conflicting autonomy of the parent and the child, and the best interest of the family and the child, brings up many challenging issues. Addressing this balance, especially in the context of the child's developing maturity and comprehension, requires deep analysis and discussion. Issues discussed include the impact of genetic information on the family, parental versus the child's autonomy, the best interests of the child versus the family, potential limitations on the parents' right to know or not know information about their child, and changing role of the developing child in return of research results. Finally, a dynamic model will be proposed that takes into consideration the child's evolving role in consenting and return of results that can be adapted in different national contexts.

Distance-based microfluidic quantitative detection methods for point-of-care testing.

PubMed

Tian, Tian; Li, Jiuxing; Song, Yanling; Zhou, Leiji; Zhu, Zhi; Yang, Chaoyong James

2016-04-07

Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings. Among various equipment-free approaches, distance-based visual quantitative detection methods rely on reading the visual signal length for corresponding target concentrations, thus eliminating the need for sophisticated instruments. The distance-based methods are low-cost, user-friendly and can be integrated into portable analytical devices. Moreover, such methods enable quantitative detection of various targets by the naked eye. In this review, we first introduce the concept and history of distance-based visual quantitative detection methods. Then, we summarize the main methods for translation of molecular signals to distance-based readout and discuss different microfluidic platforms (glass, PDMS, paper and thread) in terms of applications in biomedical diagnostics, food safety monitoring, and environmental analysis. Finally, the potential and future perspectives are discussed.

Emotional Well-Being and Public Health: Proposal for a Model National Initiative.

PubMed

Feller, Sophie C; Castillo, Enrico G; Greenberg, Jared M; Abascal, Pilar; Van Horn, Richard; Wells, Kenneth B

In 2011, the National Prevention, Health Promotion, and Public Health Council named mental and emotional well-being as 1 of 7 priority areas for the National Prevention Strategy. In this article, we discuss emotional well-being as a scientific concept and its relevance to public health. We review evidence that supports the association between emotional well-being and health. We propose a national emotional well-being initiative and describe its 6 components: systematic measurement of emotional well-being, identification of the drivers of emotional well-being, formation of partnerships with diverse stakeholders, implementation and dissemination of evidence-based interventions to promote emotional well-being and its drivers, development of public health messaging, and identification of and strategies to address disparities in emotional well-being and its drivers. Finally, we discuss ways in which a national emotional well-being initiative would complement current public health efforts and the potential challenges to such an initiative.

PRENATAL STRESS AND RISK FOR AUTISM

PubMed Central

Kinney, Dennis K.; Munir, Kerim M.; Crowley, David J.; Miller, Andrea M.

2008-01-01

This paper reviews several converging lines of research that suggest that prenatal exposure to environmental stress may increase risk for Autistic Disorder (AD). We first discuss studies finding that prenatal exposure to stressful life events is associated with significantly increased risk of AD, as well as other disorders, such as schizophrenia and depression. We then review evidence from animal and human studies that prenatal stress can produce both (a) abnormal postnatal behaviors that resemble the defining symptoms of AD, and (b) other abnormalities that have elevated rates in AD, such as learning deficits, seizure disorders, perinatal complications, immunologic and neuroinflammatory anomalies, and low postnatal tolerance for stress. We explain why an etiologic role for prenatal stress is compatible with genetic factors in AD, and describe how stress can disrupt fetal brain development. Finally, we discuss implications for understanding underlying processes in AD, including potential gene-environment interactions, and developing new therapies and early prevention programs. PMID:18598714

Information and communications technology for future health systems in developing countries.

PubMed

Lucas, Henry

2008-05-01

There has been much discussion of the role that recent advances in information and communication technologies (ICTs) could play in improving health systems in developing countries, but limited independent analysis of existing applications. Combining a case study approach with a general discussion of the issues, this paper attempts to assess the potential benefits of a diverse range of ICT innovations and some of the constraints they will need to overcome. Four broad areas are considered: improvements in traditional health information systems; computer-aided diagnosis and treatment monitoring; a range of applications generically labelled 'telemedicine'; and the use of ICT to inform general populations on health and healthcare. The final section speculates on the possible medium-term impacts of ICT in terms of improving the performance of existing systems, allowing scope for radical innovations, or even changing basic assumptions about the provider-patient relationship.

Interfaces at equilibrium: A guide to fundamentals.

PubMed

Marmur, Abraham

2017-06-01

The fundamentals of the thermodynamics of interfaces are reviewed and concisely presented. The discussion starts with a short review of the elements of bulk thermodynamics that are also relevant to interfaces. It continues with the interfacial thermodynamics of two-phase systems, including the definition of interfacial tension and adsorption. Finally, the interfacial thermodynamics of three-phase (wetting) systems is discussed, including the topic of non-wettable surfaces. A clear distinction is made between equilibrium conditions, in terms of minimizing energies (internal, Gibbs or Helmholtz), and equilibrium indicators, in terms of measurable, intrinsic properties (temperature, chemical potential, pressure). It is emphasized that the equilibrium indicators are the same whatever energy is minimized, if the boundary conditions are properly chosen. Also, to avoid a common confusion, a distinction is made between systems of constant volume and systems with drops of constant volume. Copyright © 2016 Elsevier B.V. All rights reserved.

Quantum oscillations in the kinetic energy density: Gradient corrections from the Airy gas

NASA Astrophysics Data System (ADS)

Lindmaa, Alexander; Mattsson, Ann E.; Armiento, Rickard

2014-03-01

We show how one can systematically derive exact quantum corrections to the kinetic energy density (KED) in the Thomas-Fermi (TF) limit of the Airy gas (AG). The resulting expression is of second order in the density variation and we demonstrate how it applies universally to a certain class of model systems in the slowly varying regime, for which the accuracy of the gradient corrections of the extended Thomas-Fermi (ETF) model is limited. In particular we study two kinds of related electronic edges, the Hermite gas (HG) and the Mathieu gas (MG), which are both relevant for discussing periodic systems. We also consider two systems with finite integer particle number, namely non-interacting electrons subject to harmonic confinement as well as the hydrogenic potential. Finally we discuss possible implications of our findings mainly related to the field of functional development of the local kinetic energy contribution.

Atmospheric turbulence compensation in orbital angular momentum communications: Advances and perspectives

NASA Astrophysics Data System (ADS)

Li, Shuhui; Chen, Shi; Gao, Chunqing; Willner, Alan E.; Wang, Jian

2018-02-01

Orbital angular momentum (OAM)-carrying beams have recently generated considerable interest due to their potential use in communication systems to increase transmission capacity and spectral efficiency. For OAM-based free-space optical (FSO) links, a critical challenge is the atmospheric turbulence that will distort the helical wavefronts of OAM beams leading to the decrease of received power, introducing crosstalk between multiple channels, and impairing link performance. In this paper, we review recent advances in turbulence effects compensation techniques for OAM-based FSO communication links. First, basic concepts of atmospheric turbulence and theoretical model are introduced. Second, atmospheric turbulence effects on OAM beams are theoretically and experimentally investigated and discussed. Then, several typical turbulence compensation approaches, including both adaptive optics-based (optical domain) and signal processing-based (electrical domain) techniques, are presented. Finally, key challenges and perspectives of compensation of turbulence-distorted OAM links are discussed.

Does the "new philosophy" in predictive, preventive and personalised medicine require new ethics?

PubMed

Gefenas, Eugenijus; Cekanauskaite, Asta; Tuzaite, Egle; Dranseika, Vilius; Characiejus, Dainius

2011-06-01

This paper maps the ethical issues that arise in the context of personalised medicine. First, it highlights the ethical problems related to increased predictive power of modern diagnostic interventions. Such problems emerge because the ability to identify individuals or groups of individuals that can potentially benefit from a particular therapeutic intervention also raises a question of personal responsibility for health-related behaviour and lifestyle. The second major area of ethical concern is related to health prevention and distributive justice. The paper discusses the ethical challenges brought by the personalised medicine in the context of the Additional Protocol to the Convention on Human Rights and Biomedicine concerning Genetic Testing for Health Purposes. Finally, it notes that the issue of consent in the context of biobanks, the need to rethink the prevalent models of research designs and to communicate relevant findings to the donors of biological materials deserve further discussion.

Summary of NASA/DOE Aileron-Control Development Program for Wind Turbines

NASA Technical Reports Server (NTRS)

Miller, D. R.

1986-01-01

The development of aileron-control for wind turbines is discussed. Selected wind tunnel test results and full-scale rotor test results are presented for various types of ailerons. Finally, the current status of aileron-control development is discussed. Aileron-control was considered as a method of rotor control for use on wind turbines based on its potential to reduce rotor weight and cost. Following an initial feasibility study, a 20 percent chord aileron-control rotor was fabricated and tested on the NASA/DOE Mod-0 experimental wind turbine. Results from these tests indicated that the 20 percent chord ailerons regulated power and provided overspeed protection, but only over a very limited windspeed range. The next aileron-control rotor to be tested on the Mod-0 had 38 percent chord ailerons and test results showed these ailerons provided overspeed protection and power regulation over the Mod-0's entire operational windspeed range.

Synthesis and Biomedical Applications of Poly((meth)acrylic acid) Brushes.

PubMed

Qu, Zhenyuan; Xu, Hong; Gu, Hongchen

2015-07-15

Poly((meth)acrylic acid) (P(M)AA) brushes possess a number of distinctive properties that are particularly attractive for biomedical applications. This minireview summarizes recent advances in the synthesis and biomedical applications of P(M)AA brushes and brushes containing P(M)AA segments. First, we review different surface-initiated polymerization (SIP) methods, with a focus on recent progress in the surface-initiated controlled/living radical polymerization (SI-CLRP) techniques used to generate P(M)AA brushes with a tailored structure. Next, we discuss biomolecule immobilization methods for P(M)AA brushes, including physical adsorption, covalent binding, and affinity interactions. Finally, typical biomedical applications of P(M)AA brushes are reviewed, and their performance is discussed based on their unique properties. We conclude that P(M)AA brushes are promising biomaterials, and more potential biomedical applications are expected to emerge with the further development of synthetic techniques and increased understanding of their interactions with biological systems.

Field experiments on solar geoengineering: report of a workshop exploring a representative research portfolio.

PubMed

Keith, David W; Duren, Riley; MacMartin, Douglas G

2014-12-28

We summarize a portfolio of possible field experiments on solar radiation management (SRM) and related technologies. The portfolio is intended to support analysis of potential field research related to SRM including discussions about the overall merit and risk of such research as well as mechanisms for governing such research and assessments of observational needs. The proposals were generated with contributions from leading researchers at a workshop held in March 2014 at which the proposals were critically reviewed. The proposed research dealt with three major classes of SRM proposals: marine cloud brightening, stratospheric aerosols and cirrus cloud manipulation. The proposals are summarized here along with an analysis exploring variables such as space and time scale, risk and radiative forcing. Possible gaps, biases and cross-cutting considerations are discussed. Finally, suggestions for plausible next steps in the development of a systematic research programme are presented.

Parental attitudes to a telehealth parent coaching intervention for autism spectrum disorder.

PubMed

Salomone, Erica; Maurizio Arduino, Giuseppe

2017-04-01

Introduction This study examined the potential feasibility of tele-delivered parent coaching in a rural area of Italy through a survey of parents' attitudes towards this type of intervention. Methods Parents of all children up to six years of age registered with a diagnosis of autism spectrum disorder at the clinic catering for the area were invited to take part in the study. The final sample consisted of 43 parents. Results Parents with worse Internet skills and those who reported lower levels of satisfaction with currently received services were less likely to be willing to enrol. There was a trend for parents with lower self-efficacy to be less likely to enrol. Educational level, previous experience of video-calling, travel time to the clinic and child's level of ability were not associated with the choice of enrolment. Discussion Implications for strategies to contrast barriers to adoption and strengthen implementation plans are discussed.

Pharmacogenomics to Revive Drug Development in Cardiovascular Disease.

PubMed

Dubé, Marie-Pierre; de Denus, Simon; Tardif, Jean-Claude

2016-02-01

Investment in cardiovascular drug development is on the decline as large cardiovascular outcomes trials require considerable investments in time, efforts and financial resources. Pharmacogenomics has the potential to help revive the cardiovascular drug development pipeline by providing new and better drug targets at an earlier stage and by enabling more efficient outcomes trials. This article will review some of the recent developments highlighting the value of pharmacogenomics for drug development. We discuss how genetic biomarkers can enable the conduct of more efficient clinical outcomes trials by enriching patient populations for good responders to the medication. In addition, we assess past drug development programs which support the added value of selecting drug targets that have established genetic evidence supporting the targeted mechanism of disease. Finally, we discuss how pharmacogenomics can provide valuable evidence linking a drug target to clinically relevant outcomes, enabling novel drug discovery and drug repositioning opportunities.

Graphene-based nanoprobes for molecular diagnostics.

PubMed

Chen, Shixing; Li, Fuwu; Fan, Chunhai; Song, Shiping

2015-10-07

In recent years, graphene has received widespread attention owing to its extraordinary electrical, chemical, optical, mechanical and structural properties. Lately, considerable interest has been focused on exploring the potential applications of graphene in life sciences, particularly in disease-related molecular diagnostics. In particular, the coupling of functional molecules with graphene as a nanoprobe offers an excellent platform to realize the detection of biomarkers, such as nucleic acids, proteins and other bioactive molecules, with high performance. This article reviews emerging graphene-based nanoprobes in electrical, optical and other assay methods and their application in various strategies of molecular diagnostics. In particular, this review focuses on the construction of graphene-based nanoprobes and their special advantages for the detection of various bioactive molecules. Properties of graphene-based materials and their functionalization are also comprehensively discussed in view of the development of nanoprobes. Finally, future challenges and perspectives of graphene-based nanoprobes are discussed.

Nanoparticles in the clinic

PubMed Central

Anselmo, Aaron C.

2016-01-01

Abstract Nanoparticle/microparticle‐based drug delivery systems for systemic (i.e., intravenous) applications have significant advantages over their nonformulated and free drug counterparts. For example, nanoparticle systems are capable of delivering therapeutics and treating areas of the body that other delivery systems cannot reach. As such, nanoparticle drug delivery and imaging systems are one of the most investigated systems in preclinical and clinical settings. Here, we will highlight the diversity of nanoparticle types, the key advantages these systems have over their free drug counterparts, and discuss their overall potential in influencing clinical care. In particular, we will focus on current clinical trials for nanoparticle formulations that have yet to be clinically approved. Additional emphasis will be on clinically approved nanoparticle systems, both for their currently approved indications and their use in active clinical trials. Finally, we will discuss many of the often overlooked biological, technological, and study design challenges that impact the clinical success of nanoparticle delivery systems. PMID:29313004

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical.

PubMed

Bix, Gregory J; Fraser, Justin F; Mack, William J; Carmichael, S Thomas; Perez-Pinzon, Miguel; Offner, Halina; Sansing, Lauren; Bosetti, Francesca; Ayata, Cenk; Pennypacker, Keith R

2018-06-01

The first annual Stroke Translational Research Advancement Workshop (STRAW), entitled "Uncovering the Rosetta Stone: Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical" was held at the University of Kentucky on October 4-5, 2017. This workshop was organized by the Center for Advanced Translational Stroke Science. The workshop consisted of 2 days of activities. These included three presentations establishing the areas of research in stroke therapeutics, discussing the routes for translation from bench to bedside, and identifying successes and failures in the field. On day 2, grant funding opportunities and goals for the National Institute for Neurological Diseases and Stroke were presented. In addition, the meeting also included break-out sessions designed to connect researchers in areas of stroke, and to foster potential collaborations. Finally, the meeting concluded with an open discussion among attendees led by a panel of experts.

Impact of Research and Development, Analysis, and Standardization on PV Project Financing Costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feldman, David J; Margolis, Robert M; Jones-Albertus, Rebecca

The technical report discusses how R and D efforts focused on removing perceived risk from cash flows to investors have the potential to lower the cost of capital and increase the amount of leverage in a solar project. It also discusses how creating business efficiencies that allow financing transactions to occur more quickly with less effort can reduce the upfront costs associated with arranging financing for a solar project or group of projects. The paper then assesses the impact that these R and D activities might have on the volatility of PV asset cash flows and asset value, as wellmore » as the upfront costs of arranging a financial transaction. Finally, we insert these assumptions into financial models to analyze their impacts on the cost of capital for equity and debt investors, project leverage, and upfront financial transaction costs.« less

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation

PubMed Central

Alia, Claudia; Spalletti, Cristina; Lai, Stefano; Panarese, Alessandro; Lamola, Giuseppe; Bertolucci, Federica; Vallone, Fabio; Di Garbo, Angelo; Chisari, Carmelo; Micera, Silvestro; Caleo, Matteo

2017-01-01

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration. PMID:28360842

Feasibility of self-structured current accessed bubble devices in spacecraft recording systems

NASA Technical Reports Server (NTRS)

Nelson, G. L.; Krahn, D. R.; Dean, R. H.; Paul, M. C.; Lo, D. S.; Amundsen, D. L.; Stein, G. A.

1985-01-01

The self-structured, current aperture approach to magnetic bubble memory is described. Key results include: (1) demonstration that self-structured bubbles (a lattice of strongly interacting bubbles) will slip by one another in a storage loop at spacings of 2.5 bubble diameters, (2) the ability of self-structured bubbles to move past international fabrication defects (missing apertures) in the propagation conductors (defeat tolerance), and (3) moving bubbles at mobility limited speeds. Milled barriers in the epitaxial garnet are discussed for containment of the bubble lattice. Experimental work on input/output tracks, storage loops, gates, generators, and magneto-resistive detectors for a prototype device are discussed. Potential final device architectures are described with modeling of power consumption, data rates, and access times. Appendices compare the self-structured bubble memory from the device and system perspectives with other non-volatile memory technologies.

Emerging drugs for the treatment of wound healing.

PubMed

Zielins, Elizabeth R; Brett, Elizabeth A; Luan, Anna; Hu, Michael S; Walmsley, Graham G; Paik, Kevin; Senarath-Yapa, Kshemendra; Atashroo, David A; Wearda, Taylor; Lorenz, H Peter; Wan, Derrick C; Longaker, Michael T

2015-06-01

Wound healing can be characterized as underhealing, as in the setting of chronic wounds, or overhealing, occurring with hypertrophic scar formation after burn injury. Topical therapies targeting specific biochemical and molecular pathways represent a promising avenue for improving and, in some cases normalizing, the healing process. A brief overview of both normal and pathological wound healing has been provided, along with a review of the current clinical guidelines and treatment modalities for chronic wounds, burn wounds and scar formation. Next, the major avenues for wound healing drugs, along with drugs currently in development, are discussed. Finally, potential challenges to further drug development, and future research directions are discussed. The large body of research concerning wound healing pathophysiology has provided multiple targets for topical therapies. Growth factor therapies with the ability to be targeted for localized release in the wound microenvironment are most promising, particularly when they modulate processes in the proliferative phase of wound healing.

Creativity as a Key Driver for Designing Context Sensitive Health Informatics.

PubMed

Zhou, Chunfang; Nøhr, Christian

2017-01-01

In order to face the increasing challenges of complexity and uncertainty in practice of health care, this paper aims to discuss how creativity can contribute to design new technologies in health informatics systems. It will firstly introduce the background highlighting creativity as a missing element in recent studies on context sensitive health informatics. Secondly, the concept of creativity and its relationship with activities of technology design will be discussed from a socio-culture perspective. This will be thirdly followed by understanding the roles of creativity in designing new health informatics technologies for meeting needs of high context sensitivity. Finally, a series of potential strategies will be suggested to improve creativity among technology designers working in healthcare industries. Briefly, this paper innovatively bridges two areas studies on creativity and context sensitive health informatics by issues of technology design that also indicates its important significances for future research.

(Low-level waste disposal facility siting and site characterization)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mezga, L.J.; Ketelle, R.H.; Pin, F.G.

A US team consisting of representatives of Oak Ridge National Laboratory (ORNL), Savannah River Plant (SRP), Savannah river Laboratory (SRL), and the Department of Energy Office of Defense Waste and Byproducts Management participated in the fourth meeting held under the US/French Radioactive Waste Management Agreement between the US Department of Energy and the Commissariat a l'Energie Atomique. This meeting, held at Agence Nationale pour les Gestion des Dechets Radioactifs' (ANDRA's) Headquarters in Paris, was a detailed, technical topical workshop focusing on Low-Level Waste Disposal Facility Siting and Site Characterization.'' The meeting also included a visit to the Centre de lamore » Manche waste management facility operated by ANDRA to discuss and observe the French approach to low-level waste management. The final day of the meeting was spent at the offices of Societe Generale pour les Techniques Nouvelles (SGN) discussing potential areas of future cooperation and exchange. 20 figs.« less

Synthetic Nanoelectronic Probes for Biological Cells and Tissue

PubMed Central

2013-01-01

Research at the interface between nanoscience and biology has the potential to produce breakthroughs in fundamental science and lead to revolutionary technologies. In this review, we focus on nanoelectronic/biological interfaces. First, we discuss nanoscale field effect transistors (nanoFETs) as probes to study cellular systems, including the realization of nanoFET comparable in size to biological nanostructures involved in communication using synthesized nanowires. Second, we overview current progress in multiplexed extracellular sensing using planar nanoFET arrays. Third, we describe the design and implementation of three distinct nanoFETs used to realize the first intracellular electrical recording from single cells. Fourth, we present recent progress in merging electronic and biological systems at the 3D tissue level by using macroporous nanoelectronic scaffolds. Finally, we discuss future development in this research area, the unique challenges and opportunities, and the tremendous impact these nanoFET based technologies might have in advancing biology and medical sciences. PMID:23451719

Nanoelectronics from the bottom up.

PubMed

Lu, Wei; Lieber, Charles M

2007-11-01

Electronics obtained through the bottom-up approach of molecular-level control of material composition and structure may lead to devices and fabrication strategies not possible with top-down methods. This review presents a brief summary of bottom-up and hybrid bottom-up/top-down strategies for nanoelectronics with an emphasis on memories based on the crossbar motif. First, we will discuss representative electromechanical and resistance-change memory devices based on carbon nanotube and core-shell nanowire structures, respectively. These device structures show robust switching, promising performance metrics and the potential for terabit-scale density. Second, we will review architectures being developed for circuit-level integration, hybrid crossbar/CMOS circuits and array-based systems, including experimental demonstrations of key concepts such lithography-independent, chemically coded stochastic demultipluxers. Finally, bottom-up fabrication approaches, including the opportunity for assembly of three-dimensional, vertically integrated multifunctional circuits, will be critically discussed.

Behavioral interventions to eliminate fear responses.

PubMed

Yue, Jingli; Shi, Le; Lin, Xiao; Khan, Muhammad Zahid; Shi, Jie; Lu, Lin

2018-05-07

Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder (PTSD). PTSD is a fear-based disorder, characterized by difficulties in extinguishing the learned fear response and maintaining extinction. Currently, the first-line treatment for PTSD is exposure therapy, which forms an extinction memory to compete with the original fear memory. However, the extinguished fear often returns under numerous circumstances, suggesting that novel methods are needed to eliminate fear memory or facilitate extinction memory. This review discusses research that targeted extinction and reconsolidation to manipulate fear memory. Recent studies indicate that sleep is an active state that can regulate memory processes. We also discuss the influence of sleep on fear memory. For each manipulation, we briefly summarize the neural mechanisms that have been identified in human studies. Finally, we highlight potential limitations and future directions in the field to better translate existing interventions to clinical settings.

Field experiments on solar geoengineering: report of a workshop exploring a representative research portfolio

PubMed Central

Keith, David W.; Duren, Riley; MacMartin, Douglas G.

2014-01-01

We summarize a portfolio of possible field experiments on solar radiation management (SRM) and related technologies. The portfolio is intended to support analysis of potential field research related to SRM including discussions about the overall merit and risk of such research as well as mechanisms for governing such research and assessments of observational needs. The proposals were generated with contributions from leading researchers at a workshop held in March 2014 at which the proposals were critically reviewed. The proposed research dealt with three major classes of SRM proposals: marine cloud brightening, stratospheric aerosols and cirrus cloud manipulation. The proposals are summarized here along with an analysis exploring variables such as space and time scale, risk and radiative forcing. Possible gaps, biases and cross-cutting considerations are discussed. Finally, suggestions for plausible next steps in the development of a systematic research programme are presented. PMID:25404684

Is there a doctor in the house? Standards of physician availability for laboring women.

PubMed

Minkoff, Howard; Ecker, Jeffrey

2010-09-01

Unexpected emergencies requiring urgent intervention can arise in the course of labor even among uncomplicated pregnancies in low-risk women. The possibility of such emergencies requires that responsible practitioners be available for management. The recent National Institutes of Health-sponsored consensus conference on vaginal birth after cesarean delivery highlighted this issue in discussing alternate standards of "ready" and "immediate" availability. The merits, feasibility, and ethics of alternate systems for coverage of all laboring women have not been widely or previously discussed and are considered in this opinion. Although there are potential advantages to having a responsible practitioner immediately available, logistic and economic considerations will make immediate availability unfeasible in all centers and systems, particularly on smaller services where distance or other factors may limit the option of consolidation (ie, the merging of different hospitals' obstetric services). We discuss training, systems, and planning to optimize response to emergencies in all systems, whether practitioners are readily or immediately available. Finally, we suggest that the ethical principle of respect for autonomy argues that particularly where alternate systems exist, practitioners and patients discuss the details, merits, and limitations of individual centers' clinical systems and plans for responding to emergencies.

The future of qualitative research in psychology--a discussion with Svend Brinkmann, Günter Mey, Luca Tateo, and Anete Strand.

PubMed

Demuth, Carolin; Terkildsen, Thomas

2015-06-01

In May 2014, a workshop on "The future of qualitative research in psychology" took place at Aalborg University (Denmark), Department of Communication & Psychology organized by Carolin Demuth. Participants from Aalborg University engaged in a lively exchange with the two invited discussants Svend Brinkmann (Aalborg University) and Günter Mey (Stendal University of Applied Science). The discussion started out by addressing the specifics of qualitative research in the field of psychology, its historical development and the perils of recent trends of standardization and neo-positivistic orientations. In light of the discrepancy of what could be potentially achieved with qualitative methods for psychological research and how they are actually currently applied, an emphasis was made that we need to return to an understanding of qualitative methods as a craft skill and to take into account the subjectivity of the researcher in the process of scientific knowledge production. Finally, a re-focus on experience as the genuine object of psychological research, as well as a transdisciplinary approach to our understanding of human psychological functioning within a socially co-constructed, biological, as well as material world was discussed.