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Sample records for disease utilizing satellite

  1. Predicting and Mitigating Outbreaks of Vector-Borne Disease Utilizing Satellite Remote Sensing Technology and Models

    NASA Technical Reports Server (NTRS)

    Estes, Sue; Haynes, John; Kiang, Richard; Brown, Molly; Reisen, William

    2008-01-01

    Satellite earth observations present a unique vantage point of the earth's environment from space which offers a wealth of health applications for the imaginative investigator. The session will present research results of the remote sensing environmental observations of earth and health applications. This session will an overview of many of the NASA public health applications using Remote Sensing Data and will also discuss opportunities to become a research collaborator with NASA.

  2. Predicting and Mitigating Outbreaks of Vector-Borne Disease Utilizing Satellite Remote Sensing Technology and Models

    NASA Technical Reports Server (NTRS)

    Estes, Sue M.

    2009-01-01

    The Public Health application area focuses on Earth science applications to public health and safety, particularly regarding infectious disease, emergency preparedness and response, and environmental health issues. The application explores issues of toxic and pathogenic exposure, as well as natural and man-made hazards and their effects, for risk characterization/mitigation and improvements to health and safety. The program elements of the NASA Applied Sciences Program are: Agricultural Efficiency, Air Quality, Climate, Disaster Management, Ecological Forecasting, Water Resources, Weather, and Public Health.

  3. Planning satellite communication services and spectrum-orbit utilization

    NASA Technical Reports Server (NTRS)

    Sawitz, P. H.

    1982-01-01

    The relationship between approaches to planning satellite communication services and spectrum-orbit utilization is considered, with emphasis on the fixed-satellite and the broadcasting-satellite services. It is noted that there are several possible approaches to planning space services, differing principally in the rigidity with which technical parameters are prescribed, in the time for which a plan remains in force, and in the procedures adopted for implementation and modifications. With some planning approaches, spectrum-orbit utilization is fixed at the time the plan is made. Others provide for greater flexibility by making it possible to postpone some decisions on technical parameters. In addition, the two political questions of what is equitable access and how it can be guaranteed in practice play an important role.

  4. Utilizing expert systems for satellite monitoring and control

    NASA Technical Reports Server (NTRS)

    Hughes, Peter M.

    1991-01-01

    Spacecraft analysts in the spacecraft control center for the Cosmic Background Explorer (COBE) satellite are currently utilizing a fault-isolation expert system developed to assist in the isolation and correction of faults in the communications link. This system, the communication link expert assistance resource (CLEAR), monitors real time spacecraft and ground systems performance parameters in search of configuration discrepancies and communications link problems. If such a discrepancy or problem is isolated, CLEAR alerts the analyst and provides advice on how to resolve the problem swiftly and effectively. The CLEAR system is the first real time expert system to be used in the operational environment of a satellite control center at the NASA Goddard Space Flight Center. Clear has not only demonstrated the utility and potential of an expert system in the demanding environment of a satellite control center, but also has revealed many of the pitfalls and deficiencies of development of expert systems. One of the lessons learned from this and other initial expert system projects is that prototypes can often be developed quite rapidly, but operational expert systems require considerable effort. Development is generally a slow, tedious process that typically requires the special skills of trained programmers. Due to the success of CLEAR and several other systems in the control center domain, a large number of expert systems will certainly be developed to support control center operations during the early 1990's. To facilitate the development of these systems, a project was initiated to develop an integrated, domain-specific tool, the generic spacecraft analyst assistent (GenSAA), that alows the spacecraft analysts to rapidly create simple expert systems themselves. By providing a highly graphical point-and-select method of system development, GenSAA allows the analyst to utilize and/or modify previously developed rule bases and system components; thus, facilitating

  5. Spectrum-orbit utilization - An overview. [domestic satellite communication systems

    NASA Technical Reports Server (NTRS)

    Sawitz, P. H.

    1975-01-01

    This paper discusses the problems associated with the efficient utilization of the natural resources of frequency spectrum and geo-stationary orbital arc. The nature of these resources is explained and their quantities are estimated. The present and projected future demand for them is given, and the problem areas are identified and discussed. Special emphasis is placed on mutual interference, launch limitations, propagation effects, and operational restrictions. The technical factors bearing on these problems, such as antenna patterns, modulation methods, emission restrictions, equipment characteristics, and system requirements, are discussed in detail. Some important trade-offs are presented, and special techniques that can be used to increase spectrum-orbit utilization are described. Particular emphasis is given throughout to U.S. domestic satellite communication systems.

  6. Eulusmap: An international land resources map utilizing satellite imagery

    NASA Technical Reports Server (NTRS)

    Paludan, T.; Csati, E.

    1978-01-01

    In 1972, the International Geographical Union's Commission on World Land Use Survey adopted a project for a land-use map of Europe. Such a map, under the name Eulusmap was started earlier under sponsorship of several government offices in Hungary. Although there was great response from a number of contributors in many countries, it became evident by mid-1974 that the map would contain gaps and some inaccuracies unless additional data sources were utilized. By then, the satellite Landsat-1 had obtained imagery of most of Europe. Using theme extraction techniques, the map was completed in draft form and portions of it displayed at the 23d International Geographical Congress in Moscow during July 1976. Printing of the completed map was accomplished in May 1978.

  7. Utilization of NASA Lewis mobile terminals for the Hermes satellite

    NASA Technical Reports Server (NTRS)

    Edelman, E. A.; Fiala, J. L.; Rizzolla, L.

    1977-01-01

    The paper describes the portable earth terminal (PET) and the transportable earth terminal (TET) which enable two-way television and voice communication. Both terminals were developed by NASA and utilize the high power of the Hermes satellite. PET is a bus-type vehicle which has receiving equipment for full duplex color television and which can transmit programs originating in either the on-board PET studio or in nearby buildings. PET has a collapsible 2.4-m diameter parabolic antenna interfacing with a 500-watt 14-GHz wideband TV transmitter and a 12-GHz wideband TV receiver system. TET uses two parabolic reflector antennas, 3 m and 1.2 m in diameter, mounted on a flat trailer towed by a truck. TET can receive and relay color TV signals, and its narrowband transmitter can serve as a return audio link permitting a question-and-answer format. Also described are uplink and downlink performance characteristics, operation procedures, and field demonstrations which enabled personnel at several hospitals to participate in a distant medical conference.

  8. Multipath study for a low altitude satellite utilizing a data relay satellite system

    NASA Technical Reports Server (NTRS)

    Eggert, D.

    1970-01-01

    Technical considerations associated with a low altitude satellite operating in conjuction with a data relay satellite system are reported. Emphasis was placed on the quantitative characterization of multipath phenomenon and determination of power received via both the direct and earth reflection paths. Attempts were made to develop a means for estimating the magnitude and nature of the reflected power.

  9. Satellite Attitude Control Utilizing the Earth's Magnetic Field

    NASA Technical Reports Server (NTRS)

    White, John S.; Shigemoto, Fred H.; Bourquin, Kent

    1961-01-01

    A study was conducted to determine the feasibility of a satellite attitude fine-control system using the interaction of the earth's magnetic field with current-carrying coils to produce torque. The approximate intensity of the earth's magnetic field was determined as a function of the satellite coordinates. Components of the magnetic field were found to vary essentially sinusoidally at approximately twice orbital frequency. Amplitude and distortion of the sinusoidal components were a function of satellite orbit. Two systems for two-axis attitude control evolved from this study, one using three coils and the other using two coils. The torques developed by the two systems differ only when the component of magnetic field along the tracking line is zero. For this case the two-coil system develops no torque whereas the three-coil system develops some effective torque which allows partial control. The equations which describe the three-coil system are complex in comparison to those of the two-coil system and require the measurement of all three components of the magnetic field as compared with only one for the two-coil case. Intermittent three-axis torquing can also be achieved. This torquing can be used for coarse attitude control, or for dumping the stored momentum of inertia reaction wheels. Such a system has the advantage of requiring no fuel aboard the satellite. For any of these magnetic torquing schemes the power required to produce the magnetic moment and the weight of the coil seem reasonable.

  10. Proposed advanced satellite applications utilizing space nuclear power systems

    NASA Technical Reports Server (NTRS)

    Bailey, Patrick G.; Isenberg, Lon

    1990-01-01

    A review of the status of space nuclear reactor systems and their possible applications is presented. Such systems have been developed over the past twenty years and are capable of use in various military and civilian applications in the 5-1000-kWe power range. The capabilities and limitations of the currently proposed nuclear reactor systems are summarized. Statements of need are presented from DoD, DOE, and NASA. Safety issues are identified, and if they are properly addressed they should not pose a hindrance. Applications are summarized for the DoD, DOE, NASA, and the civilian community. These applications include both low- and high-altitude satellite surveillance missions, communications satellites, planetary probes, low- and high-power lunar and planetary base power systems, broadband global telecommunications, air traffic control, and high-definition television.

  11. Passive Micro Vibration Isolator Utilizing Flux Pinning Effect for Satellites

    NASA Astrophysics Data System (ADS)

    Shibata, Takuma; Sakai, Shin-ichiro

    2016-09-01

    Information related to the origin of space and evolution of galaxy can be obtained using the observation satellites. In recent years, high pointing accuracy is demanded for getting more detailed data about distant stars and galaxies. As a result, vibration isolators that consist of a main structure and a TTM (Tip Tilt Mirror) have been adopted for observation satellites. However, cutting the low frequency vibrations off passively with the conventional methods is difficult. A vibration isolator that uses pinning effect is proposed for solving this problem. The pinning effect is acquired by cooling the type-II superconductor below the critical temperature and it generates a pinning force to maintain the relative distance and attitude between a type- II superconductor and a material that generates magnetic flux. The mission part and the bus part of the satellite are equipped with superconductors and permanent magnets and these parts perform short distance formation flight by applying the effect. This method can cut vibrations from low to high frequency bands off passively. In addition, Meissner effect can prevent collision of the mission and bus parts. In order to investigate the performance of this system, experiments and simulations are carried out and the results are discussed.

  12. Utilizing a TDRS satellite for direct broadcast satellite-radio propagation experiments and demonstrations

    NASA Technical Reports Server (NTRS)

    Hollansworth, James E.

    1993-01-01

    The NASA/VOA Direct Broadcast Satellite-Radio (DBS-R) Program will be using a NASA Tracking Data Relay Satellite (TDRS) satellite at 62 deg. West longitude to conduct live satellite S-band propagation experiments and demonstrations of satellite sound broadcasting over the next two years (1993-1994). The NASA/VOA DBS-R program has applied intensive effort to garner domestic and international support for the DBS-R concept. An S-band DBS-R allocation was achieved for Region 2 at WARC-92 held in Spain. With this allocation, the DBS-R program now needs to conduct S-band propagation experiments and systems demonstrations that will assist in the development of planning approaches for the use of Broadcast Satellite Service (Sound) frequency bands prior to the planning conference called for by WARC-92. These activities will also support receiver concept development applied to qualities ranging from AM to Monophonic FM, Stereophonic FM, Monophonic CD, and Stereophonic CD quality.

  13. Utilizing a TDRS satellite for direct broadcast satellite-radio propagation experiments and demonstrations

    NASA Technical Reports Server (NTRS)

    Hollansworth, James E.

    1993-01-01

    The NASA/VOA Direct Broadcast Satellite - Radio (DBS-R) Program will be using a NASA Tracking Data Relay Satellite (TDRS) satellite at 62 deg West longitude to conduct live satellite S-band propagation experiments and demonstrations of satellite sound broadcasting over the next two years (1993-1994). The NASA/VOA DBS-R program has applied intensive effort to garner domestic and international support for the DBS-R concept. An S-band DBS-R allocation was achieved for Region 2 at WARC-92 held in Spain. With this allocation, the DBS-R program now needs to conduct S-band propagation experiments and systems demonstrations that will assist in the development of planning approaches for the use of Broadcast Satellite Service (Sound) frequency bands prior to the planning conference called for by WARC-92. These activities will also support receiver concept development applied to qualities ranging from AM to Monophonic FM, Stereophonic FM, Monophonic CD, and Stereophonic CD quality.

  14. Utilization of NASA Lewis mobile terminals for the Hermes satellite

    NASA Technical Reports Server (NTRS)

    Edelman, E. A.; Fiala, J. L.; Rizzolla, L.

    1977-01-01

    The high power of the Hermes satellite enables two-way television and voice communication with small ground terminals. The Portable Earth Terminal (PET) and the Transportable Earth Terminal (TET) were developed and built by NASA-Lewis to provide communications capability to short-term users. The NASA-Lewis mobile terminals are described in terms of vehicles and onboard equipment, as well as operation aspects, including use in the field. The section on demonstrations divides the uses into categories of medicine, education, technology and government. Applications of special interest within each category are briefly described.

  15. Utilizing a TDRS satellite for direct broadcast satellite-radio propagation experiments and demonstrations

    NASA Technical Reports Server (NTRS)

    Hollansworth, James E.

    1993-01-01

    The NASA/VOA Direct Broadcast Satellite - Radio (DBS-R) Program will be using a NASA Tracking Data Relay Satellite (TDRS) at 62 deg West longitude to conduct live satellite S-band propagation experiments and demonstrations of satellite sound broadcasting over the next two years (1993-1994). The NASA/VOA DBS-R program has applied intensive effort to garner domestic and international support for the DBS-R concept. An S-band DBS-R allocation was achieved for Region 2 at WARC-92 held in Spain. With this allocation, the DBS-R program now needs to conduct S-band propagation experiments and systems demonstrations that will assist in the development of planning approaches for the use of Broadcast Satellite Service (Sound) frequency bands prior to the planning conference called for by WARC-92. These activities will also support receiver concept development applied to qualities ranging from AM to Monophonic FM, Stereophonic FM, Monophonic CD, and Stereophonic CD quality.

  16. Satellite applications to electric-utility communications needs. [land mobile satellite service

    NASA Technical Reports Server (NTRS)

    Horstein, M.; Barnett, R.

    1981-01-01

    Significant changes in the Nation's electric power systems are expected to result from the integration of new technology, possible during the next decade. Digital communications for monitor and control, exclusive of protective relaying, are expected to double or triple current traffic. A nationwide estimate of 13 Mb/s traffic is projected. Of this total, 8 Mb/s is attributed to the bulk-power system as it is now being operated (4 Mb/s). This traffic could be accommodated by current communications satellites using 3- to 4.5-m-diameter ground terminals costing $35,000 to $70,000 each. The remaining 5-Mb/s traffic is attributed to new technology concepts integrated into the distribution system. Such traffic is not compatible with current satellite technology because it requires small, low-cost ground terminals. Therefore, a high effective isotropic radiated power satellite, such as the one being planned by NASA for the Land Mobile Satellite Service, is required.

  17. A Survey of the Utility of Satellite Magnetometer Data for Application to Solid-earth Geophysical and Geological Studies

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A survey of potential users of low altitude satellite magnetic measurements for solid-earth and geological studies was conducted. The principal objectives of this survey were to: document the utility and application of the data and resultant products obtained from such a satellite mission, and establish a users committee for the proposed low altitude vector magnetometer satellite.

  18. Satellites

    SciTech Connect

    Burns, J.A.; Matthews, M.S.

    1986-01-01

    The present work is based on a conference: Natural Satellites, Colloquium 77 of the IAU, held at Cornell University from July 5 to 9, 1983. Attention is given to the background and origins of satellites, protosatellite swarms, the tectonics of icy satellites, the physical characteristics of satellite surfaces, and the interactions of planetary magnetospheres with icy satellite surfaces. Other topics include the surface composition of natural satellites, the cratering of planetary satellites, the moon, Io, and Europa. Consideration is also given to Ganymede and Callisto, the satellites of Saturn, small satellites, satellites of Uranus and Neptune, and the Pluto-Charon system.

  19. Enhanced satellite bandwidth utilization by optimum integration of split trunks and transcoders

    NASA Astrophysics Data System (ADS)

    Kansal, Vivek; Satija, S. M.

    1992-03-01

    A technique for satellite transponder capacity enhancement used in the Indian Telecon Network is described which uses the advantages of low rate encoding and an appropriate mix of incoming trunks from the terrestrial side using the principle of Time Slot Interchange. This approach enhances satellite channel utilization in case of preassigned connectivity by eliminating unused channels from inputs. The system is transparent to the user. The ADPCM gain is about two for all voice channels and reduces as the data channels increase. The multiplexing and TSIC operation has a significant gain in case the partially assigned input trunks which can be combined to form a lesser number of output trunks.

  20. Effective Utilization of Satellite Observations for Assessing Transnational Impact of Disasters

    NASA Astrophysics Data System (ADS)

    Alozie, J. E.; Anuforom, A. C.

    2014-12-01

    General meteorological observations sources for the surface, upper air and outer space are conducted using different technological equipment and instruments that meet international standards prescribed and approved by the United Nations organizations such as the International Civil Aviation Organization (ICAO) and the World Meteorological Organization (WMO). Satellite weather observations are critical for effective monitoring of the developments, propagations and disseminations of cold clouds and their expected adverse weather conditions as they move across national and transnational boundaries. The Nigerian Meteorological Agency (NiMet) which is the national weather service provider for Nigeria, utilizes an array of satellite products obtained from mainly the European Meteorological Satellite (EUMETSAT) for its routine weather and climate monitoring and forecasts. Overtime, NiMet has used weather workstations such as MSG, SYNERGIE and now PUMA for accessing satellite products such as RGB, Infra-red, Water vapour and the Multi-sensor Precipitation Estimate (MPE) obtained at near real-time periods. The satellite imageries find extensive applications in the delivery of early warning of raising of severe weather conditions such as dust storm and dust haze during the harmattan season (November - February); and thunderstorm accompanied by severe lightning and destructive strong winds. The paper will showcase some special cases of the tracking of squall lines and issuance of weather alerts through the media. The good result is that there was limited damage to infrastructure and no loss of life from the flash floods caused by the heavy rainfall from the squally thunderstorm.

  1. A new formulation of spectrum-orbit utilization efficiency for satellite communications in interference-limited situations

    NASA Astrophysics Data System (ADS)

    Lee, L.-S.

    1984-02-01

    The spectrum-orbit utilization efficiency of satellite communications is becoming increasingly important. A first attempt is made in this paper to try to formulate the spectrum-orbit utilization efficiency in interference-limited situations by defining the self-efficiency for a single satellite, and the cross-efficiency and coordination efficiency for each pair of adjacent satellites. The various technical aspects and complicated interference considerations relevant to spectrum-orbit utilization can all be reasonably reflected by these simple efficiency parameters. They tell the behavior of each satellite by itself and with its neighbors. Such a formulation is therefore very useful for improving the spectrum-orbit utilization efficiency in future satellite communications.

  2. Utilization of Precipitation and Moisture Products Derived from Satellites to Support NOAA Operational Precipitation Forecasts

    NASA Astrophysics Data System (ADS)

    Ferraro, R.; Zhao, L.; Kuligowski, R. J.; Kusselson, S.; Ma, L.; Kidder, S. Q.; Forsythe, J. M.; Jones, A. S.; Ebert, E. E.; Valenti, E.

    2012-12-01

    NOAA/NESDIS operates a constellation of polar and geostationary orbiting satellites to support weather forecasts and to monitor the climate. Additionally, NOAA utilizes satellite assets from other U.S. agencies like NASA and the Department of Defense, as well as those from other nations with similar weather and climate responsibilities (i.e., EUMETSAT and JMA). Over the past two decades, through joint efforts between U.S. and international government researchers, academic partners, and private sector corporations, a series of "value added" products have been developed to better serve the needs of weather forecasters and to exploit the full potential of precipitation and moisture products generated from these satellites. In this presentation, we will focus on two of these products - Ensemble Tropical Rainfall Potential (eTRaP) and Blended Total Precipitable Water (bTPW) - and provide examples on how they contribute to hydrometeorological forecasts. In terms of passive microwave satellite products, TPW perhaps is most widely used to support real-time forecasting applications, as it accurately depicts tropospheric water vapor and its movement. In particular, it has proven to be extremely useful in determining the location, timing, and duration of "atmospheric rivers" which contribute to and sustain flooding events. A multi-sensor approach has been developed and implemented at NESDIS in which passive microwave estimates from multiple satellites and sensors are merged to create a seamless, bTPW product that is more efficient for forecasters to use. Additionally, this product is being enhanced for utilization for television weather forecasters. Examples will be shown to illustrate the roll of atmospheric rivers and contribution to flooding events, and how the bTPW product was used to improve the forecast of these events. Heavy rains associated with land falling tropical cyclones (TC) frequently trigger floods that cause millions of dollars of damage and tremendous loss

  3. Impacts and Benefits of a Satellite Power System on the Electric Utility Industry

    NASA Technical Reports Server (NTRS)

    Winer, B. M.

    1977-01-01

    The purpose of this limited study was to investigate six specific issues associated with interfacing a Satellite Power System (5 GW) with large (by present standards) terrestrial power pools to a depth sufficient to determine if certain interface problems and/or benefits exist and what future studies of these problems are required. The issues investigated are as follows: (1) Stability of Power Pools Containing a 5 GWe SPS; (2) Extra Reserve Margin Required to Maintain the Reliability of Power Pools Containing a 5 GWe SPS; (3) Use of the SPS in Load Following Service (i.e. in two independent pools whose times of peak demand differ by three hours); (4) Ownership of the SPS and its effect on SPS Usage and Utility Costs; (5) Utility Sharing of SPS related RD and D Costs; (6) Utility Liability for SPS Related Hazards.

  4. A digitally implemented communications experiment utilizing the communications technology satellite, Hermes

    NASA Technical Reports Server (NTRS)

    Jackson, H. D.; Fiala, J.

    1980-01-01

    Developments which will reduce the costs associated with the distribution of satellite services are considered with emphasis on digital communication link implementation. A digitally implemented communications experiment (DICE) which demonstrates the flexibility and efficiency of digital transmission of television video and audio, telephone voice, and high-bit-rate data is described. The utilization of the DICE system in a full duplex teleconferencing mode is addressed. Demonstration teleconferencing results obtained during the conduct of two sessions of the 7th AIAA Communication Satellite Systems Conference are discussed. Finally, the results of link characterization tests conducted to determine (1) relationships between the Hermes channel 1 EIRP and DICE model performance and (2) channel spacing criteria for acceptable multichannel operation, are presented.

  5. The utilization of nonterrestrial materials. [resources for solar power satellite construction

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The development of research and technology programs on the user of nonterrestrial materials for space applications was considered with emphasis on the space power satellite system as a model of large space systems for which the use of nonterrestrial materials may be economically viable. Sample topics discussed include the mining of raw materials and the conversion of raw materials into useful products. These topics were considered against a background of the comparative costs of using terrestrial materials. Exploratory activities involved in the preparation of a nonterrestrial materials utilization program, and the human factors involved were also addressed. Several recommendations from the workshop are now incorporated in NASA activities.

  6. Examining the utility of satellite-based wind sheltering estimates for lake hydrodynamic modeling

    USGS Publications Warehouse

    2014-01-01

    Satellite-based measurements of vegetation canopy structure have been in common use for the last decade but have never been used to estimate canopy's impact on wind sheltering of individual lakes. Wind sheltering is caused by slower winds in the wake of topography and shoreline obstacles (e.g. forest canopy) and influences heat loss and the flux of wind-driven mixing energy into lakes, which control lake temperatures and indirectly structure lake ecosystem processes, including carbon cycling and thermal habitat partitioning. Lakeshore wind sheltering has often been parameterized by lake surface area but such empirical relationships are only based on forested lakeshores and overlook the contributions of local land cover and terrain to wind sheltering. This study is the first to examine the utility of satellite imagery-derived broad-scale estimates of wind sheltering across a diversity of land covers. Using 30 m spatial resolution ASTER GDEM2 elevation data, the mean sheltering height, hs, being the combination of local topographic rise and canopy height above the lake surface, is calculated within 100 m-wide buffers surrounding 76,000 lakes in the U.S. state of Wisconsin. Uncertainty of GDEM2-derived hs was compared to SRTM-, high-resolution G-LiHT lidar-, and ICESat-derived estimates of hs, respective influences of land cover type and buffer width on hs are examined; and the effect of including satellite-based hs on the accuracy of a statewide lake hydrodynamic model was discussed. Though GDEM2 hs uncertainty was comparable to or better than other satellite-based measures of hs, its higher spatial resolution and broader spatial coverage allowed more lakes to be included in modeling efforts. GDEM2 was shown to offer superior utility for estimating hs compared to other satellite-derived data, but was limited by its consistent underestimation of hs, inability to detect within-buffer hs variability, and differing accuracy across land cover types. Nonetheless

  7. Analysis on the Utility of Satellite Imagery for Detection of Agricultural Facility

    NASA Astrophysics Data System (ADS)

    Kang, J.-M.; Baek, S.-H.; Jung, K.-Y.

    2012-07-01

    Now that the agricultural facilities are being increase owing to development of technology and diversification of agriculture and the ratio of garden crops that are imported a lot and the crops cultivated in facilities are raised in Korea, the number of vinyl greenhouses is tending upward. So, it is important to grasp the distribution of vinyl greenhouses as much as that of rice fields, dry fields and orchards, but it is difficult to collect the information of wide areas economically and correctly. Remote sensing using satellite imagery is able to obtain data of wide area at the same time, quickly and cost-effectively collect, monitor and analyze information from every object on earth. In this study, in order to analyze the utilization of satellite imagery at detection of agricultural facility, image classification was performed about the agricultural facility, vinyl greenhouse using Formosat-2 satellite imagery. The training set of sea, vegetation, building, bare ground and vinyl greenhouse was set to monitor the agricultural facilities of the object area and the training set for the vinyl greenhouses that are main monitoring object was classified and set again into 3 types according the spectral characteristics. The image classification using 4 kinds of supervise classification methods applied by the same training set were carried out to grasp the image classification method which is effective for monitoring agricultural facilities. And, in order to minimize the misclassification appeared in the classification using the spectral information, the accuracy of classification was intended to be raised by adding texture information. The results of classification were analyzed regarding the accuracy comparing with that of naked-eyed detection. As the results of classification, the method of Mahalanobis distance was shown as more efficient than other methods and the accuracy of classification was higher when adding texture information. Hence the more effective

  8. Earth-satellite propagation above GHz: Papers from the 1972 spring URSI session on experiments utilizing the ATS-5 satellite

    NASA Technical Reports Server (NTRS)

    Ippolito, L. J. (Compiler)

    1972-01-01

    Papers are reported from the Special Session on Earth-Satellite Propagation Above 10 GHz, presented at The 1972 Spring Meeting of the United States National Committee, International Union of Radio Science, April 1972, Washington, D. C. This session was devoted to propagation measurements associated with the Applications Technology Satellite (ATS-5), which provided the first operational earth-space links at frequencies above 15 GHz. A comprehensive summary is presented of the major results of the ATS-5 experiment measurements and related radiometric, radar and meteorological studies. The papers are organized around seven selected areas of interest, with the results of the various investigators combined into a single paper presented by a principal author for that area. A comprehensive report is provided on the results of the ATS-5 satellite to earth transmissions. A complete list of published reports and presentations related to the ATS-5 Millimeter Wave Experiment is included.

  9. Utilizing Satellite Precipitation Products to Understand the Link Between Climate Variability and Malaria

    NASA Astrophysics Data System (ADS)

    Maggioni, V.; Mousam, A.; Delamater, P. L.; Cash, B. A.; Quispe, A.

    2015-12-01

    Malaria is a public health threat to people globally leading to 198 million cases and 584,000 deaths annually. Outbreaks of vector borne diseases such as malaria can be significantly impacted by climate variables such as precipitation. For example, an increase in rainfall has the potential to create pools of water that can serve as breeding locations for mosquitos. Peru is a country that is currently controlling malaria, but has not been able to completely eliminate the disease. Despite the various initiatives in order to control malaria - including regional efforts to improve surveillance, early detection, prompt treatment, and vector management - malaria cases in Peru have risen between 2011 and 2014. The purpose of this study is to test the hypothesis that climate variability plays a fundamental role in malaria occurrence over a 12-year period (2003-2014) in Peru. When analyzing climate variability, it is important to obtain high-quality, high-resolution data for a time series long enough to draw conclusion about how climate variables have been and are changing. Remote sensing is a powerful tool for measuring and monitoring climate variables continuously in time and space. A widely used satellite-based precipitation product, the Tropical Rainfall Measuring Mission (TRMM) Multi-satellite Precipitation Analysis (TMPA), available globally since 1998, was used to obtain 3-hourly data with a spatial resolution of 0.25° x 0.25°. The precipitation data was linked to weekly (2003-2014) malaria cases collected by health centers and available at a district level all over Peru to investigate the relationship between precipitation and the seasonal and annual variations in malaria incidence. Further studies will incorporate additional climate variables such as temperature, humidity, soil moisture, and surface pressure from remote sensing data products and climate models. Ultimately, this research will help us to understand if climate variability impacts malaria incidence

  10. Development of U.S. Government General Technical Requirements for UAS Flight Safety Systems Utilizing the Iridium Satellite Constellation

    NASA Technical Reports Server (NTRS)

    Murray, Jennifer; Birr, Richard

    2010-01-01

    This slide presentation reviews the development of technical requirements for Unmanned Aircraft Systems (UAS) utilization of the Iridium Satellite Constellation to provide flight safety. The Federal Aviation Authority (FAA) required an over-the-horizon communication standard to guarantee flight safety before permitting widespread UAS flights in the National Air Space (NAS). This is important to ensure reliable control of UASs during loss-link and over-the-horizon scenarios. The core requirement was to utilize a satellite system to send GPS tracking data and other telemetry from a flight vehicle down to the ground. Iridium was chosen as the system because it is one of the only true satellite systems that has world wide coverage, and the service has a highly reliable link margin. The Iridium system, the flight modems, and the test flight are described.

  11. The utility of digital subtraction arteriography in peripheral vascular disease.

    PubMed

    Kubal, W S; Crummy, A B; Turnipseed, W D

    1983-01-01

    Digital subtraction angiography (DSA), whether used in conjunction with intravenous or intraarterial injection techniques, has an established role in evaluation of peripheral vascular disease. Use of DSA can reduce the time, cost, and patient discomfort of the standard arteriographic study. While it is limited by field size and patient cooperation in some instances, the utility of noninvasive imaging using intravenous DSA and the added anatomic detail of intraarterial DSA for roadmapping and delineation of small distal vessels provide the basis for future integration of standard arteriographic and DSA methods in assessment of peripheral vascular disease. PMID:6228296

  12. Utility of Noninvasive Markers of Fibrosis in Cholestatic Liver Diseases.

    PubMed

    Corpechot, Christophe

    2016-02-01

    Methods of liver fibrosis assessment have changed considerably in the last 20 years, and noninvasive markers now have been recognized as major first-line tools in the management of patients with chronic viral hepatitis infection. But what about the efficiency and utility of these surrogate indices for the more uncommon chronic cholestatic liver diseases, namely primary biliary cirrhosis and primary sclerosing cholangitis? This article provides clinicians with a global overview of what is currently known in the field. Both diagnostic and prognostic aspects of noninvasive markers of fibrosis in cholestatic liver diseases are presented and discussed.

  13. Factors affecting frequency and orbit utilization by high power transmission satellite systems

    NASA Technical Reports Server (NTRS)

    Kuhns, P. W.; Miller, E. F.; Malley, T. A.

    1972-01-01

    The factors affecting the sharing of the geostationary orbit by high power (primarily television) satellite systems having the same or adjacent coverage areas and by satellites occupying the same orbit segment are examined and examples using the results of computer computations are given. The factors considered include: required protection ratio, receiver antenna patterns, relative transmitter power, transmitter antenna patterns, satellite grouping, and coverage pattern overlap. The results presented indicated the limits of system characteristics and orbit deployment which can result from mixing systems.

  14. Detection of regional air pollution episodes utilizing satellite digital data in the visual range

    NASA Technical Reports Server (NTRS)

    Burke, H.-H. K.

    1982-01-01

    Digital analyses of satellite visible data for selected high-sulfate cases over the northeastern U.S., on July 21 and 22, 1978, are compared with ground-based measurements. Quantitative information on total aerosol loading derived from the satellite digitized data using an atmospheric radiative transfer model is found to agree with the ground measurements, and it is shown that the extent and transport of the haze pattern may be monitored from the satellite data over the period of maximum intensity for the episode. Attention is drawn to the potential benefits of satellite monitoring of pollution episodes demonstrated by the model.

  15. Utilization of satellite data and regional scale numerical models in short range weather forecasting

    NASA Technical Reports Server (NTRS)

    Kreitzberg, C. W.

    1985-01-01

    Overwhelming evidence was developed in a number of studies of satellite data impact on numerical weather prediction that it is unrealistic to expect satellite temperature soundings to improve detailed regional numerical weather prediction. It is likely that satellite data over the United States would substantially impact mesoscale dynamical predictions if the effort were made to develop a composite moisture analysis system. The horizontal variability of moisture, most clearly depicited in images from satellite water vapor channels, would not be determined from conventional rawinsondes even if that network were increased by a doubling of both the number of sites and the time frequency.

  16. Application of communications satellites to educational development. [technology utilization/information systems - bibliographies

    NASA Technical Reports Server (NTRS)

    Morgan, R. P.

    1975-01-01

    A summary of research is presented. The broad objectives of this interdisciplinary research effort were: (1) to assess the role of satellite communications as a means of improving education in the United States, as well as in less-developed areas of the world; (2) to generate basic knowledge which will aid in making rational decisions about satellite application in the field of education in the years ahead; (3) to devise systems and strategies for improving education; and (4) to educate individuals who will be knowledgeable about aspects of satellite communications policy which transcend any single discipline.

  17. Association of Satellites with a Mastrevirus in Natural Infection: Complexity of Wheat Dwarf India Virus Disease

    PubMed Central

    Kumar, Jitendra; Kumar, Jitesh; Singh, Sudhir P.

    2014-01-01

    Dwarf India Virus (WDIV), isolated from two distant locations in India. This study reports the first identification of the satellites in a monocot plant. The satellites enhanced accumulation of WDIV and severity of disease symptoms. The satellites lowered the concentration of virus-specific small RNAs in wheat plants, indicating their silencing suppressor activity. The involvement of the satellites in symptom severity of the mastrevirus can have implications in the form of economic impact of the virus on crop yield. Understanding the role of the satellites in disease severity is important for developing disease management strategies. PMID:24719407

  18. Utility of transcranial ultrasound in predicting Alzheimer's disease risk.

    PubMed

    Tomek, Aleš; Urbanová, Barbora; Hort, Jakub

    2014-01-01

    Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by an increasing incidence. One of the pathologic processes that underlie this disorder is impairment of brain microvasculature. Transcranial ultrasound is a non-invasive examination of cerebral blood flow that can be employed as a simple and useful screening tool for assessing the vascular status of brain circulation in preclinical and clinical stages of AD. The objective of this review is to explore the utility of using a transcranial ultrasound to diagnose AD. With transcranial ultrasound, the most frequently studied parameters are cerebral blood flow velocities and pulsatility indices, cerebrovascular reserve capacity, and cerebral microembolization. On the basis of current knowledge, we recommend using as a transcranial Doppler sonography screening method of choice the assessment of cerebrovascular reserve capacity with breath-holding test. PMID:25298200

  19. Investigation of biomass burning and aerosol loading and transport in South America utilizing geostationary satellites

    NASA Technical Reports Server (NTRS)

    Menzel, Paul; Prins, Elaine

    1995-01-01

    This study attempts to assess the extent of burning and associated aerosol transport regimes in South America and the South Atlantic using geostationary satellite observations, in order to explore the possible roles of biomass burning in climate change and more directly in atmospheric chemistry and radiative transfer processes. Modeling and analysis efforts have suggested that the direct and indirect radiative effects of aerosols from biomass burning may play a major role in the radiative balance of the earth and are an important factor in climate change calculations. One of the most active regions of biomass burning is located in South America, associated with deforestation in the selva (forest), grassland management, and other agricultural practices. As part of the NASA Aerosol Interdisciplinary Program, we are utilizing GOES-7 (1988) and GOES-8 (1995) visible and multispectral infrared data (4, 11, and 12 microns) to document daily biomass burning activity in South America and to distinguish smoke/aerosols from other multi-level clouds and low-level moisture. This study catalogues the areal extent and transport of smoke/aerosols throughout the region and over the Atlantic Ocean for the 1988 (July-September) and 1995 (June-October) biomass burning seasons. The smoke/haze cover estimates are compared to the locations of fires to determine the source and verify the haze is actually associated with biomass burning activities. The temporal resolution of the GOES data (half-hourly in South America) makes it possible to determine the prevailing circulation and transport of aerosols by considering a series of visible and infrared images and tracking the motion of smoke, haze and adjacent clouds. The study area extends from 40 to 70 deg W and 0 to 40 deg S with aerosol coverage extending over the Atlantic Ocean when necessary. Fire activity is estimated with the GOES Automated Biomass Burning Algorithm (ABBA). To date, our efforts have focused on GOES-7 and GOES-8 ABBA

  20. Improved CMAQ predictions of particulate matter utilizing the satellite-derived aerosol optical depth

    NASA Astrophysics Data System (ADS)

    Lee, Daegyun; Byun, Daewon W.; Kim, Hyuncheol; Ngan, Fong; Kim, Soontae; Lee, Chongbum; Cho, Changrae

    2011-07-01

    Regional air quality models such as the Community Multiscale Air Quality (CMAQ) model have been widely used to study and simulate multi-scale air quality issues. Although they are capable of providing high quality atmospheric chemistry profiles through the utilization of high resolution inputs relating meteorology and emissions with chemical reactions, they cannot simulate air quality accurately if other input data are not appropriate and reliable. There have been few studies on the importance of chemical initial conditions (ICs) as it is considered that the impact of concentration fields specified at the beginning of simulation wears off quickly. This paper demonstrates that the significant errors during the early part of the simulation can damage model predictions and conversely if the ICs are prescribed appropriately with available observations, they can compensate for the shortcomings of the air quality prediction system especially when the episode-based emissions inputs representing real-life emission variations such as forest fires as well as the effects of long-range transport events that are not reflected in the basic model inputs. The key hypothesis of the present study is that prediction of aerosols can be improved by the initialization of the aerosol fields with the satellite-derived Aerosol Optical Depth (AOD). We compare the effects of using fine mode and total AOD for the initialization in terms of regional bias characteristics. We found that the impacts of two-step initial conditions adjustments could be substantial in the case of aerosol events such as wildfires, which the present modeling system does not consider during simulation due to the deficiency in the emission inputs. The total AOD case helped to refine PM 2.5 predictions over the northwestern area, where wildfire events occurred, for the fire event days improving the correlation coefficient significantly from 0.12 to 0.67. CMAQ predicted PM 2.5 concentrations in the fine mode case

  1. Utility of regional satellite volcano deformation monitoring in Latin America: The CEOS pilot project

    NASA Astrophysics Data System (ADS)

    Delgado, F.; Pritchard, M. E.; Biggs, J.; Arnold, D.

    2014-12-01

    Satellite observations are a cost effective tool for monitoring large numbers of volcanoes in areas with scarce instrumentation or difficult access. In the context of the 2012 Santorini Report on satellite Earth Observation and Geohazards, CEOS (Committee on Earth Observation Satellites) has developed a pilot project to showcase remote sensing for volcano hazard mitigation and response. Specifically, the pilot aims to demonstrate the feasibility of global volcano monitoring of Holocene volcanoes by undertaking regional monitoring of volcanic arcs in Latin America, using satellite earth observations data to track deformation as well as gas, ash, and thermal emissions. Latin America was chosen because the volcanoes are situated in a diversity of environments, providing a good test of the capabilities of different types of satellite data under different conditions; volcanic activity is abundant, and monitoring agencies in Latin American countries would directly benefit from the resources that this pilot will make available. It is hoped that the regional study will demonstrate that Earth observation data can help to identify volcanoes that may become active in the future as well as track eruptive activity that may impact populations and infrastructure on the ground and in the air, ultimately leading to improved targeting for permanent satellite-based observations and in-situ volcanic monitoring efforts. The pilot project is posible thanks to data provided by the various space agencies (ESA, ASI, DLR, JAXA, NASA, CNES, CSA). In this contribution, we focus on premilinary ground deformation results using SAR satellites for selected areas in the Northern and Southern Andes as well as the Caribbean with recent unrest. For example, in the Southern Andes we will present ALOS time series at Llaima (-38.7 S) and Peteroa (-35.2 S) volcanoes, both of which have had eruptions during the past ten years.

  2. Detection of regional air pollution episodes utilizing satellite data in the visual range

    NASA Technical Reports Server (NTRS)

    Bowley, C. J.; Burke, H. K.; Barnes, J. C.

    1981-01-01

    A comparative analysis of satellite-observed haze patterns and ground-based aerosol measurements is carried out for July 20-23, 1978. During this period, a significant regional air pollution episode existed across the northeastern United States, accompanied by widespread haze, reduced surface visibility, and elevated sulfate levels measured by the Sulfate Regional Experiment (SURE) network. The results show that the satellite-observed haze patterns correlate closely with the area of reported low surface visibility (less than 4 mi) and high sulfate levels. Quantitative information on total aerosol loading derived from the satellite-digitized data, using an atmospheric radiative transfer model, agrees well with the results obtained from the ground-based measurements.

  3. Space-shuttle interfaces/utilization. Earth Observatory Satellite system definition study (EOS)

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The economic aspects of space shuttle application to a representative Earth Observatory Satellite (EOS) operational mission in the various candidate Shuttle modes of launch, retrieval, and resupply are discussed. System maintenance of the same mission capability using a conventional launch vehicle is also considered. The studies are based on application of sophisticated Monte Carlo mission simulation program developed originally for studies of in-space servicing of a military satellite system. The program has been modified to permit evaluation of space shuttle application to low altitude EOS missions in all three modes. The conclusions generated by the EOS system study are developed.

  4. Recent Developments, Utilization, and Spending Trends for Pompe Disease Therapies

    PubMed Central

    Guo, Jing; Kelton, Christina M.L.; Guo, Jeff J.

    2012-01-01

    Background Pompe disease is a rare condition, with an incidence rate estimated to be between 1 in 40,000 and 1 in 300,000 live births worldwide. For an infant who contracts the disease, which is an inherited metabolic myopathy caused by deficiency of the acid alpha-glucosidase (GAA) enzyme in lysosomal cells, the survival rate to age 1 year is estimated to be 25.7%. Before 2006, no therapies were available for this disease. Objectives The goals of this study were to review recent developments in therapies for Pompe disease, including the US Food and Drug Administration (FDA) approval of 2 biologic drugs, and to describe the associated drug utilization and spending trends in the US Medicaid program for patients with this disease. Methods We reviewed 2 recently approved therapies for Pompe disease and compared their indications, as well as their efficacy and safety profiles. A retrospective analysis was performed using the national Medicaid pharmacy claims database. Quarterly prescriptions and reimbursement amounts were calculated for each drug from 2006 quarter 2 through 2011 quarter 2. Average per-prescription spending was calculated by dividing the drug reimbursement by the number of prescriptions written for that drug. Results Myozyme (alglucosidase alfa, recombinant human GAA) and Lumizyme (alglucosidase alfa), the first 2 enzyme replacement therapies available for Pompe disease, were approved as orphan drugs by the FDA in 2006 and in 2010, respectively. Myozyme is indicated for infantile-onset Pompe disease; Lumizyme is indicated for patients aged ≥8 years. Although both drugs have been shown to improve patient survival rates, they both also have a boxed warning, because of the possibility of life-threatening allergic reactions. Moreover, Lumizyme has a restricted distribution system to ensure it is used by the correct patient population. In 2010, Medicaid spending for Myozyme was $3.6 million. In the first 2 quarters of 2011, Medicaid spending for Lumizyme

  5. Clinical Utility of Serologic Testing for Celiac Disease in Ontario

    PubMed Central

    2010-01-01

    tests in the diagnosis celiac disease? What is the clinical validity of serologic tests in the diagnosis of celiac disease? The clinical validity was defined as the ability of the test to change diagnosis. What is the clinical utility of serologic tests in the diagnosis of celiac disease? The clinical utility was defined as the impact of the test on decision making. What is the budget impact of serologic tests in the diagnosis of celiac disease? What is the cost-effectiveness of serologic tests in the diagnosis of celiac disease? Methods Literature Search A literature search was performed on November 13th, 2009 using OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE, the Cumulative Index to Nursing & Allied Health Literature (CINAHL), the Cochrane Library, and the International Agency for Health Technology Assessment (INAHTA) for studies published from January 1st 2003 and November 13th 2010. Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained. Reference lists were also examined for any additional relevant studies not identified through the search. Articles with unknown eligibility were reviewed with a second clinical epidemiologist, then a group of epidemiologists until consensus was established. The quality of evidence was assessed as high, moderate, low or very low according to GRADE methodology. Inclusion Criteria Inclusion Criteria Exclusion Criteria Studies that evaluated diagnostic accuracy, i.e., both sensitivity and specificity of serology tests in the diagnosis of celiac disease. Study population consisted of untreated patients with symptoms consistent with celiac disease. Studies in which both serologic celiac disease tests and small bowel biopsy (gold standard) were used in all subjects. Systematic reviews, meta-analyses, randomized controlled trials, prospective observational studies, and retrospective cohort studies. At least 20 subjects included in

  6. Instantaneous Shoreline Extraction Utilizing Integrated Spectrum and Shadow Analysis From LiDAR Data and High-resolution Satellite Imagery

    NASA Astrophysics Data System (ADS)

    Lee, I.-Chieh

    manually connected, for its length was less than 3% of the total shoreline length in our dataset. Secondly, the parameters for satellite image classification needed to be manually determined. The need for manpower was significantly less compared to the ground surveying or aerial photogrammetry. The first phase of shoreline extraction was to utilize Normalized Difference Vegetation Index (NDVI), Mean-Shift segmentation on the coordinate (X, Y, Z), and attributes (multispectral bands from satellite images) of the LiDAR points to classify each LiDAR point into land or water surface. Boundary of the land points were then traced to create the shoreline. The second phase of shoreline extraction solely from satellite images utilized spectrum, NDVI, and shadow analysis to classify the satellite images into classes. These classes were then refined by mean-shift segmentation on the panchromatic band. By tracing the boundary of the water surface, the shoreline can be created. Since these two shorelines may represent different shoreline instances in time, evaluating the changes of shoreline was the first to be done. Then an independent scenario analysis and a procedure are performed for the shoreline of each of the three conditions: in the process of erosion, in the process of accession, and remaining the same. With these three conditions, we could analysis the actual terrain type and correct the classification errors to obtain a more accurate shoreline. Meanwhile, methods of evaluating the quality of shorelines had also been discussed. The experiment showed that there were three indicators could best represent the quality of the shoreline. These indicators were: (1) shoreline accuracy, (2) land area difference between extracted shoreline and ground truth shoreline, and (3) bias factor from shoreline quality metrics.

  7. Analysis of the proposed utilization of TDRS system by the HEAO-C satellite

    NASA Technical Reports Server (NTRS)

    Weathers, G.

    1974-01-01

    The primary function of the study was to assess the impact upon the HEAO telecommunications system of the proposed relay satellite-to-ground-link configuration. The system is designed to perform the function of most of the NASA ground tracking and communications network at a net cost savings for NASA.

  8. ERTS-B (Earth Resources Technology Satellite). [spacecraft design remote sensor description, and technology utilization

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Mission plans and objectives of the ERTS 2 Satellite are presented. ERTS 2 follow-on investigations in various scientific disciplines including agriculture, meteorology, land-use, geology, water resources, oceanography, and environment are discussed. Spacecraft design and its sensors are described along with the Delta launch vehicle and launch operations. Applications identified from ERTS 1 investigations are summarized.

  9. Utilization of Satellite Data in Land Surface Hydrology: Sensitivity and Assimilation

    NASA Technical Reports Server (NTRS)

    Lakshmi, Venkataraman; Susskind, Joel

    1999-01-01

    This paper investigates the sensitivity of potential evapotranspiration to input meteorological variables, viz- surface air temperature and surface vapor pressure. The sensitivity studies have been carried out for a wide range of land surface variables such as wind speed, leaf area index and surface temperatures. Errors in the surface air temperature and surface vapor pressure result in errors of different signs in the computed potential evapotranspiration. This result has implications for use of estimated values from satellite data or analysis of surface air temperature and surface vapor pressure in large scale hydrological modeling. The comparison of cumulative potential evapotranspiration estimates using ground observations and satellite observations over Manhattan, Kansas for a period of several months shows very little difference between the two. The cumulative differences between the ground based and satellite based estimates of potential evapotranspiration amounted to less that 20mm over a 18 month period and a percentage difference of 15%. The use of satellite estimates of surface skin temperature in hydrological modeling to update the soil moisture using a physical adjustment concept is studied in detail including the extent of changes in soil moisture resulting from the assimilation of surface skin temperature. The soil moisture of the surface layer is adjusted by 0.9mm over a 10 day period as a result of a 3K difference between the predicted and the observed surface temperature. This is a considerable amount given the fact that the top layer can hold only 5mm of water.

  10. The potential utility of land surface modeling and data assimilation for satellite soil moisture validation activities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In the past five years, a number of different modeling and/or data assimilation strategies have been introduced to conduct validation/evaluation of satellite-based surface soil moisture retrievals. These strategies can be (roughly) separated into three separate categories: 1) triple collocation (TC)...

  11. Accessing and Utilizing Remote Sensing Data for Vectorborne Infectious Diseases Surveillance and Modeling

    NASA Technical Reports Server (NTRS)

    Kiang, Richard; Adimi, Farida; Kempler, Steven

    2008-01-01

    Background: The transmission of vectorborne infectious diseases is often influenced by environmental, meteorological and climatic parameters, because the vector life cycle depends on these factors. For example, the geophysical parameters relevant to malaria transmission include precipitation, surface temperature, humidity, elevation, and vegetation type. Because these parameters are routinely measured by satellites, remote sensing is an important technological tool for predicting, preventing, and containing a number of vectorborne infectious diseases, such as malaria, dengue, West Nile virus, etc. Methods: A variety of NASA remote sensing data can be used for modeling vectorborne infectious disease transmission. We will discuss both the well known and less known remote sensing data, including Landsat, AVHRR (Advanced Very High Resolution Radiometer), MODIS (Moderate Resolution Imaging Spectroradiometer), TRMM (Tropical Rainfall Measuring Mission), ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer), EO-1 (Earth Observing One) ALI (Advanced Land Imager), and SIESIP (Seasonal to Interannual Earth Science Information Partner) dataset. Giovanni is a Web-based application developed by the NASA Goddard Earth Sciences Data and Information Services Center. It provides a simple and intuitive way to visualize, analyze, and access vast amounts of Earth science remote sensing data. After remote sensing data is obtained, a variety of techniques, including generalized linear models and artificial intelligence oriented methods, t 3 can be used to model the dependency of disease transmission on these parameters. Results: The processes of accessing, visualizing and utilizing precipitation data using Giovanni, and acquiring other data at additional websites are illustrated. Malaria incidence time series for some parts of Thailand and Indonesia are used to demonstrate that malaria incidences are reasonably well modeled with generalized linear models and artificial

  12. Global brightness temperature spectra at high wavenumbers utilizing satellite microwave measurements

    NASA Astrophysics Data System (ADS)

    Stanford, J. L.

    1980-05-01

    Satellite microwave brightness temperature (radiance) measurements represent weighted mean temperatures in a certain atmospheric layer. The high density of measurements along a polar-orbiting satellite track allows estimates of the brightness temperature variance spectrum at high meridional wavenumbers. Global data from the Nimbus 6 SCAMS microwave instrument sensitive to the 100-300 mb layer have been analyzed for 30 days in August 1975. The results reveal that the brightness temperature variance spectrum can be fit to the form k to the m power over the range k = 22 to 59 (horizontal wavelengths 1800 to 700 km). Using 95% confidence intervals, the fit yields m = minus 3.1 plus or minus 0.3. These results appear to have significance for estimates of energy cascade between different motion scales in the very high wavenumber regime.

  13. An investigation into new advances in geodesy utilizing future satellite constellations

    NASA Astrophysics Data System (ADS)

    Gunter, B.; Teixeira da Encarnacao, J.; Ditmar, P.; Klees, R.

    2011-12-01

    The ability to measure temporal gravity field variations is of great interest to the Earth sciences community. These gravity measurements provide a unique source of information about Earth's mass transport processes, such as ocean currents, sea-level change, atmospheric variations, continental hydrology, movements of the solid earth, and the flux of ice in the cryosphere. Dedicated gravity field missions such as the Gravity Recovery and Climate Experiment (GRACE) have been collecting valuable global time-variable gravity measurements for nearly a decade now; however, as a single instrument pair, the spatial and temporal resolution of the GRACE mission is inherently limited by its ground track coverage. The information from these dedicated missions could be significantly enhanced if the information from a constellation of (non-dedicated) satellites were available. For example, the precise positions determined from a constellation of satellites equipped with GNSS receivers could be differentiated to reveal the gravitational accelerations acting on each satellite. The measurements from the constellation would not match the accuracy of those collected from GRACE, but would be sufficient to observe the large scale (> 1000 km) gravity variations. More importantly, these variations would be observed at time scales as short as six hours, covering a spectrum of the gravity field not possible from missions such as GRACE. In this context, the gravity data from the constellation would provide new information about Earth's global gravity field that would be fully complementary to data from dedicated gravity missions. In addition, the gravity data from the constellations could serve as an independent source of global time-variable gravity data in the event there is a gap between the end of the current GRACE mission (est. 2015-2016) and the proposed GRACE follow-on mission. Such constellations could soon become a reality, as satellite networks such as Iridium NEXT and others are

  14. a Comparative Study on Utilization of Multi-Sensor Satellite Data to Detect Potential Fishing Zone (pfz)

    NASA Astrophysics Data System (ADS)

    Balaguru, B.; Ramakrishnan, S. S.; Vidhya, R.; Thanabalan, T.

    2014-11-01

    The satellite oceanography reveals the rolls on Potential Fishing Zone (PFZ) advisories in India is limited by the availability of the satellite data during the cloudy days and for the cloudy areas, because of the inability of the passive sensors to pass through the clouds. However, there is a huge demand from the fishermen community to provide PFZ advisories on cloudy days / monsoon period also as the period corresponds to the peak fishing season. Keeping in view of the demand and availability of the optimally interpolated merged product from Altimetry, it is proposed to utilize 4 km SST product obtained from the AVHRR. In view of this, a comparative analysis has been carried out on the feasibility of utilization of the Altimetry product for identification of PFZ Advisories. The analysis is carried out the synergize study on existing in AVHRR SST product are really matching with the high resolution EKE and SSHA products derived from Altimetry. From the analysis it was found that the Altimetry product is suitable for identifying cold core generation of waters for PFZ advisories with certain limitations. Also persistence of the ocean color environmental variables is cross-verified with catch weight observed from In-situ observation. The overall analysis derived from ocean color and altimetry products for delineating potential fishing zones enhance flawless information for future research.

  15. Environmental waste site characterization utilizing aerial photographs and satellite imagery: Three sites in New Mexico, USA

    SciTech Connect

    Van Eeckhout, E.; Pope, P.; Becker, N.; Wells, B.; Lewis, A.; David, N.

    1996-04-01

    The proper handling and characterization of past hazardous waste sites is becoming more and more important as world population extends into areas previously deemed undesirable. Historical photographs, past records, current aerial satellite imagery can play an important role in characterizing these sites. These data provide clear insight into defining problem areas which can be surface samples for further detail. Three such areas are discussed in this paper: (1) nuclear wastes buried in trenches at Los Alamos National Laboratory, (2) surface dumping at one site at Los Alamos National Laboratory, and (3) the historical development of a municipal landfill near Las Cruces, New Mexico.

  16. Central electrical utility power for a satellite ring city in low earth orbit space

    NASA Technical Reports Server (NTRS)

    Myers, Ira T.; Faymon, Karl A.; Patton, A. D.

    1989-01-01

    Information is given in viewgraph form on central electrical power for a satellite ring city, defined as a group of large free flyers of 10 to 20 units with perhaps 100 people in each unit, and organized in a circle so that power can be fed from a central location. The free flyers would be located at 300 to 700 miles in altitude, and spaced about a kilometer apart. Potential activities of a ring city are listed as well as the electrical power needs. Information is given on costs and individual and centralized solar arrays and nuclear reactor systems.

  17. Cerebral glucose utilization and blood flow in Huntington's Disease (HD)

    SciTech Connect

    Phelps, M.E.; Mazziotta, J.C.; Wapenski, J.; Riege, W.; Baxter, L.R.

    1985-05-01

    Previous studies in the authors' Laboratory have been carried out on 13 patients symptomatic of HD (SHD) and 15 asymptomatic at-risk for HD (ARHD) with a ECAT II and identification of changes in caudate metabolism using an index technique. The authors report now studies of additional 28 subjects (11 SHD, 17 ARHD) studied drug free and compared to age/sex matched controls using the higher resolution NeuroECAT, FDG for glucose utilization (LCMRGlc) and 0-15 water for cerebral blood flow (CBF). Patients had neurological, psychiatric-tests, x-ray CT and were video taped to determine type, timing and amount of choreathetic movements during study. In SHD (disease duration 4.9 +- 2.7 yrs), significant decreases (30%) in LCMRGlc were found in striatum (SHD=19.3 +- 7.7, controls = 29.9 +- 5.8 ..mu.. moles/min/100g) despite no to moderate caudate atrophy on x-ray CT. Hemisphere and cortical CMRGlc were not significantly decreased. There was a significant correlation between disease duration and ratio of caudate to putamen (Cd/Put). Pattern of LCMRGlc and CBF matched in SHD. The caudate to hemisphere LCMRGlc ratio was not different between ARHD and controls except variance was about 4 times greater for ARHD (ARHD=1.21 +- 0.15, controls = 1.28 +- 0.04) indicating presence of subpopulations in ARHD group. Four ARHD subjects had a ratio of 1 Std. Dev. from mean of SHD (no normals had values in this range). The 2 ARHD subjects with lowest caudate LCMRGlc had Cd/Put ratios > 2 Std. Dev. from controls. Results show 1) LCMRGlc abnormalities in all SHD patients and subpopulations in ARHD, 2) metabolic alterations appear to begin in caudate and spread to putamen and that a Cd/Put value of 0.7 should be found at start of symptoms, and 3) cortex and thalamus are relatively spared in ARHD and early SHD.

  18. Utility of hemodialysis in maple syrup urine disease.

    PubMed

    Puliyanda, Dechu P; Harmon, William E; Peterschmitt, M Judith; Irons, Mira; Somers, Michael J G

    2002-04-01

    Maple syrup urine disease (MSUD) is an inborn error of metabolism stemming from a deficiency in 2-ketoacid dehydrogenase and resulting in the systemic accumulation of branched chain amino acids (BCAAs). Affected children may suffer profound developmental and cognitive impairment from exposure to high levels of BCAA and their associated neurotoxic metabolites. Endogenous renal clearance of BCAA is limited and several therapeutic modalities including intensive nutritional regimens, exchange transfusions, peritoneal dialysis, and continuous hemofiltration have been utilized in neonates with MSUD, all of which have had varying success in reducing systemic BCAA levels. In this report, a symptomatic 7-day-old 3-kg neonate with MSUD underwent treatment with a combination of early hemodialysis and aggressive enteral feedings of a metabolically appropriate formula. This approach results in a 75% reduction of systemic toxin levels within 3 h. When compared to other reported modalities of therapy for symptomatic neonates with MSUD, this approach appears to be most efficacious. Moreover, by minimizing the amount of time that an affected neonate is exposed to neurotoxic levels of BCAAs, long-term developmental and cognitive capabilities may be preserved.

  19. Catastrophic approach to satellite imagery utilization on network-based flight simulators

    NASA Astrophysics Data System (ADS)

    Levin, Eugene; Ternovskiy, Igor V.

    2001-11-01

    Presently, there are many technological and industrial efforts for development of virtual flight simulators, usually based on networked technologies. In order to solve the problems of real time availability and realistic quality of simulators, source data images and digital terrain models (DTM) should have some generalized structure, which supposes different imagery resolution and different amount of detail on each level of 3D simulation. One of the central problems is geotruthing of satellite imagery with realistic accuracy requirements with respect to DTM. Traditionally such geotruthing can be achieved by means of geo control points measurements. This process is labor intensive and requires special photogrammetric operator skills. In order to avoid such a process an algorithm of terrain and image models singularity's recognition based on Catastrophe theory is investigated in this paper. This approach does not require training but operates with direct comparison of the analytical manifolds from DTM with those actually extracted from the image. The technology described in this paper, the Catastrophe Approach, and algorithms of satellite imagery treatment may be implemented in a multi-level image pyramid flight simulators. Theoretical approaches and practical realization indicates that the Catastrophe Approach is easy- to-use for a final customer and can be implemented on-line to networked flight simulators.

  20. Utility of Satellite Magnetic Observations for Estimating Near-Surface Magnetic Anomalies

    NASA Technical Reports Server (NTRS)

    Kim, Hyung Rae; vonFrese, Ralph R. B.; Taylor, Patrick T.; Kim, Jeong Woo; Park, Chan Hong

    2003-01-01

    Regional to continental scale magnetic anomaly maps are becoming increasingly available from airborne, shipborne, and terrestrial surveys. Satellite data are commonly considered to fill the coverage gaps in regional compilations of these near-surface surveys. For the near-surface Antarctic magnetic anomaly map being produced by the Antarctic Digital Magnetic Anomaly Project (ADMAP), we show that near-surface magnetic anomaly estimation is greatly enhanced by the joint inversion of the near-surface data with the satellite observations relative to the conventional technique such as minimum curvature. Orsted observations are especially advantageous relative to the Magsat data that have order-of-magnitude greater measurement errors, albeit at much lower orbital altitudes. CHAMP is observing the geomagnetic field with the same measurement accuracy as the Orsted mission, but at the lower orbital altitudes covered by Magsat. Hence, additional significant improvement in predicting near-surface magnetic anomalies can result as these CHAMP data are available. Our analysis also suggests that considerable new insights on the magnetic properties of the lithosphere may be revealed by a further order-of-magnitude improvement in the accuracy of the magnetometer measurements at minimum orbital altitude.

  1. Assessing Wildlife Habitat And Range Utilization in Arizona Using Satellite Data

    NASA Astrophysics Data System (ADS)

    Hutchinson, C. F.; Marsh, S. E.; Krausman, P. R.; Enns, R. M.; Howery, L. D.; Trobia, E.; Wallace, C. S.; Walker, J. J.; Mauz, K.; Boyd, H.; Salazar, H.

    2001-05-01

    Since their reintroduction in 1914, elk (Cervus elaphus) have grown to be a major issue in the western United States. Most land is controlled by federal or state agencies, but individual ranchers have agreements that permit them to graze cattle on much of this land. Elk often compete with cattle for forage, and damage infrastructure (i.e. fences, watering points, and crops). Conversely, environmentalists and hunters also have an interest in the management of elk populations. As a result, consequence of these conflicting interests, there is little agreement about the size of the elk population or the nature, location, and timing of conflicts that elk might cause. This study was intended to provide information that might help managers understand the distribution of elk in Arizona as a consequence of seasonal variation and in response to extreme climatic events (i.e. El Niño and La Niña). The first task involved modeling elk populations over time. There are no long term or large-scale studies of elk movements through continuous observation (i.e. radiocollars). A technique for modeling elk population has been developed that is based on harvest data, gender ratios, and estimates of male mortality. This provided estimates of elk populations for individual game management units (areas for which harvest is reported and within which elk are managed by the Arizona Game and Fish Department). The second task involved the use of satellite data to characterize vegetation responses to seasonal and interannual climate variation among vegetation associations within game management units. This involved the use of NOAA Advanced Very High Resolution Radiometer (AVHRR) time series data to describe temporal vegetation behavior, Landsat and Ikonos data to describe spatial vegetation distribution in conjunction with U.S. Forest Service vegetation maps. Elk population estimates were correlated with satellite-derived vegetation measures by vegetation association through time. The patterns

  2. Forecasting distributions of large federal-lands fires utilizing satellite and gridded weather information

    USGS Publications Warehouse

    Preisler, H.K.; Burgan, R.E.; Eidenshink, J.C.; Klaver, Jacqueline M.; Klaver, R.W.

    2009-01-01

    The current study presents a statistical model for assessing the skill of fire danger indices and for forecasting the distribution of the expected numbers of large fires over a given region and for the upcoming week. The procedure permits development of daily maps that forecast, for the forthcoming week and within federal lands, percentiles of the distributions of (i) number of ignitions; (ii) number of fires above a given size; (iii) conditional probabilities of fires greater than a specified size, given ignition. As an illustration, we used the methods to study the skill of the Fire Potential Index an index that incorporates satellite and surface observations to map fire potential at a national scale in forecasting distributions of large fires. ?? 2009 IAWF.

  3. A gradient model of vegetation and climate utilizing NOAA satellite imagery. Phase 1: Texas transect

    NASA Technical Reports Server (NTRS)

    Greegor, D.; Norwine, J. (Principal Investigator)

    1981-01-01

    A climatological model/variable termed the sponge (a measure of moisture availability based on daily temperature maxima and minima, and precipitation) was tested for potential biogeograhic, ecological, and agro-climatological applications. Results, depicted in tabular and graphic form, suggest that, as generalized climatic index, sponge is particularly appropriate for large-area and global vegetation monitoring. The feasibility of utilizing NOAA/AVHRR data for vegetation classification was investigated and a vegetation gradient model that utilizes sponge and AVHRR data was initiated. Along an east-west Texas gradient, vegetation, sponge, and AVHRR pixel data (channels 1 and 2) were obtained for 12 locations. The normalized difference values for the AVHRR data when plotted against vegetation characteristics (biomass, net productivity, leaf area) and sponge values along the Texas gradient suggest that a multivariate gradient model incorporating AVHRR and sponge data may indeed be useful in global vegetation stratification and monitoring.

  4. A gradient model of vegetation and climate utilizing NOAA satellite imagery. Phase 1: Texas transect

    NASA Technical Reports Server (NTRS)

    Greegor, D. H.; Norwine, J.

    1981-01-01

    A new experimental climatological model/variable termed the sponge, a measure of moisture availability based on daily temperature maxima and minima and precipitation, is tested for potential biogeographic, ecological, and agro-climatological applications. Results, depicted in tabular and graphic from, suggest that, as a generalized climatic index, sponge's simplicity and sensitivity make particularly appropriate for trans-regional biogeographic studies (e.g., large-area and global vegetation monitoring). The feasibility of utilizing NOAA/AVHRR data for vegetation classification was investigated and a vegetation gradient model that utilizes sponge, and AVHRR pixel data (channels 1 and 2) were obtained for 12 locations. The normalized difference values for the AVHRR data when plotted against vegetation characteristics (biomass, net productivity, leaf area) and sponge values suggest that a multivariate gradient model incorporating AVHRR and sponge data may indeed be useful in global vegetation stratification and monitoring.

  5. Utility of Satellite Data to monitor drought and floods in India

    NASA Astrophysics Data System (ADS)

    Mishra, V.

    2015-12-01

    Extreme hydrologic events such as droughts and floods pose tremendous pressure on society. The damage due to extreme events has increased during the recent decades and it may increase even further under the projected future climate. Real time monitoring of hydrologic extremes is essential to minimize losses to society and infrastructure. However, in many areas, where gauge based observations are not available in timely manner, real-time monitoring of droughts and floods has been challenging. In the absence of in-situ gauge based observations, satellite data from the various platform may provide an useful information for the real-time monitoring. Using the precipitation data from the Tropical Rainfall Measurement Mission (TRMM) a real-time monitor that updates on daily basis was developed for India. The hydrologic variables (soil moisture, runoff, and Evapotranspiration) were simulated using the Variable Infiltration Capacity (VIC) model. The real-time monitor was successfully evaluated for the drought and flood monitoring in India. The monitor provides soil moisture and total runoff conditions at a high resolution. Moreover, the monitor can provide a valuable information on daily streamflow monitoring at the selected gauge stations in India.

  6. Utilization of VAS satellite data in the initialization of an oceanic-cyclogenesis simulation

    NASA Technical Reports Server (NTRS)

    Douglas, Sharon G.; Warner, Thomas T.

    1986-01-01

    A series of experiments was performed to test various method of incorporating Visible Infrared Spin Scan Radiometer Atmospheric Sounder (VAS)-sounding data into the initial conditions of the Penn State University/National Center for Atmospheric mesoscale model. The VAS data for this ocean-cyclogenesis case consist of 110 irregularly distributed temperature and humidity soundings located over the North Pacific Ocean and apply at approximately 1200 GMT 10 November 1981. Various methods of utilizing VAS data in the initial condition of a mesoscale model were evaluated.

  7. Snowline and Glacier Assessment in the Central Hindu Kush, Afghanistan, Utilizing Multi- Temporal Satellite Imagery

    NASA Astrophysics Data System (ADS)

    Haritashya, U. K.; Bishop, M. P.; Shroder, J. F.; Bulley, H. N.; Olsenholler, J. A.; Sartan, J. N.

    2006-12-01

    Snow- and glacier-covered massifs in Afghanistan represent the main source of fresh water for the country. Although it is widely recognized that these high altitude cryospheric components are highly sensitive to climatic fluctuation, very little information on changing conditions in Afghanistan have been reported. Climate simulations representing a carbon-dioxide-loading scenario suggest Afghanistan, and the Hindu Kush and Karakoram of Pakistan, could exhibit greater rates of change than in the eastern Himalaya. Consequently, our objective was to assess changes in snowline altitude and glacier areas over a thirty year period. Specifically, we used multi-temporal satellite imagery from different optical sensors from 1973 2002 to assess snowline altitude variations and glacier retreat in the Central Hindu Kush, Afghanistan. Landsat MSS, Landsat TM and ASTER imagery were orthorectified and radiometrically calibrated, and a digital elevation model was generated using ASTER data. We developed a semi-automatic pixel-based, multi-spectral, classification method that incorporates spectral and topographic information. The ASTER-derived DEM represented the baseline elevation reference. Our results are based upon analysis of 12 mountain massifs and 80 glaciers, and indicate that the snowline altitude has increased by approximately 200 m in the last three decades. Results also show glacier retreat and the disconnection of tributary glaciers to their main trunk glacier. In addition, the increase in meltwater production is evident on some glaciers, as revealed by variation in the frequency and size of supraglacial and proglacial lakes. These cryospheric changes can be linked to regional-scale climate change that is affecting the water resource supply in this chronically arid Hindu Kush area. There is an urgent need to conduct fieldwork to obtain direct measurements to further document rapid change due to climate forcing.

  8. Monitoring Disease Trends using Hospital Traffic Data from High Resolution Satellite Imagery: A Feasibility Study

    PubMed Central

    Nsoesie, Elaine O.; Butler, Patrick; Ramakrishnan, Naren; Mekaru, Sumiko R.; Brownstein, John S.

    2015-01-01

    Challenges with alternative data sources for disease surveillance include differentiating the signal from the noise, and obtaining information from data constrained settings. For the latter, events such as increases in hospital traffic could serve as early indicators of social disruption resulting from disease. In this study, we evaluate the feasibility of using hospital parking lot traffic data extracted from high-resolution satellite imagery to augment public health disease surveillance in Chile, Argentina and Mexico. We used archived satellite imagery collected from January 2010 to May 2013 and data on the incidence of respiratory virus illnesses from the Pan American Health Organization as a reference. We developed dynamical Elastic Net multivariable linear regression models to estimate the incidence of respiratory virus illnesses using hospital traffic and assessed how to minimize the effects of noise on the models. We noted that predictions based on models fitted using a sample of observations were better. The results were consistent across countries with selected models having reasonably low normalized root-mean-squared errors and high correlations for both the fits and predictions. The observations from this study suggest that if properly procured and combined with other information, this data source could be useful for monitoring disease trends. PMID:25765943

  9. Satellite Hyperspectral Imagery to Support Tick-Borne Infectious Diseases Surveillance

    PubMed Central

    Polo, Gina; Labruna, Marcelo Bahia; Ferreira, Fernando

    2015-01-01

    This study proposed the use of satellite hyperspectral imagery to support tick-borne infectious diseases surveillance based on monitoring the variation in amplifier hosts food sources. To verify this strategy, we used the data of the human rickettsiosis occurrences in southeastern Brazil, region in which the emergence of this disease is associated with the rising capybara population. Spatio-temporal analysis based on Monte Carlo simulations was used to identify risk areas of human rickettsiosis and hyperspectral moderate-resolution imagery was used to identify the increment and expansion of sugarcane crops, main food source of capybaras. In general, a pixel abundance associated with increment of sugarcane crops was detected in risk areas of human rickettsiosis. Thus, the hypothesis that there is a spatio-temporal relationship between the occurrence of human rickettsiosis and the sugarcane crops increment was verified. Therefore, due to the difficulty of monitoring locally the distribution of infectious agents, vectors and animal host’s, satellite hyperspectral imagery can be used as a complementary tool for the surveillance of tick-borne infectious diseases and potentially of other vector-borne diseases. PMID:26599337

  10. Monitoring disease trends using hospital traffic data from high resolution satellite imagery: a feasibility study.

    PubMed

    Nsoesie, Elaine O; Butler, Patrick; Ramakrishnan, Naren; Mekaru, Sumiko R; Brownstein, John S

    2015-03-13

    Challenges with alternative data sources for disease surveillance include differentiating the signal from the noise, and obtaining information from data constrained settings. For the latter, events such as increases in hospital traffic could serve as early indicators of social disruption resulting from disease. In this study, we evaluate the feasibility of using hospital parking lot traffic data extracted from high-resolution satellite imagery to augment public health disease surveillance in Chile, Argentina and Mexico. We used archived satellite imagery collected from January 2010 to May 2013 and data on the incidence of respiratory virus illnesses from the Pan American Health Organization as a reference. We developed dynamical Elastic Net multivariable linear regression models to estimate the incidence of respiratory virus illnesses using hospital traffic and assessed how to minimize the effects of noise on the models. We noted that predictions based on models fitted using a sample of observations were better. The results were consistent across countries with selected models having reasonably low normalized root-mean-squared errors and high correlations for both the fits and predictions. The observations from this study suggest that if properly procured and combined with other information, this data source could be useful for monitoring disease trends.

  11. Objective Operational Utilization of Satellite Microwave Scatterometer Observations of Tropical Cyclones

    NASA Technical Reports Server (NTRS)

    Cardone, Vincent J.; Cox, Andrew T.

    2000-01-01

    This study has demonstrated that high-resolution scatterometer measurements in tropical cyclones and other high-marine surface wind regimes may be retrieved accurately for wind speeds up to about 35 mls (1-hour average at 10 m) when the scatterometer data are processed through a revised geophysical model function, and a spatial adaptive algorithm is applied which utilizes the fact that wind direction is so tightly constrained in tile inner core of severe marine storms that wind direction may be prescribed from conventional data. This potential is demonstrated through case studies with NSCAT data in a severe West Pacific Typhoon (Violet, 1996) and an intense North Atlantic hurricane (Lili, 1996). However, operational scatterometer winds from NSCAT and QuickScat in hurricanes and severe winter storms are biased low in winds above 25 m/s. We have developed an inverse model to specify the entire surface wind field about a tropical cyclone from operational QuickScat scatterometer measurements within 150 nm of a storm center with the restriction that only wind speeds up to 20 m/s are used until improved model function are introduced. The inverse model is used to specify the wind field over the entire life-cycle of Hurricane Floyd (1999) for use to drive an ocean wave model. The wind field compares very favorably with wind fields developed from the copious aircraft flight level winds obtained in this storm.

  12. Utilization of Satellite Dish Technology and its Application in Taping PeachStar Programming: A Survey of Library Media Specialists.

    ERIC Educational Resources Information Center

    Razza, Betsy L.

    Through lottery funding, all public schools in Georgia received satellite dish equipment. This study is an assessment of the use of the satellite dish equipment by library media specialists in the DeKalb County School System for taping PeachStar (the satellite channel of Georgia Public Broadcasting) programming. The purpose was four-fold: (1) to…

  13. Drug utilization of clarithromycin for gastrointestinal disease treatment

    PubMed Central

    Zhou, Quan; Zhu, Ling-Ling; Yan, Xiao-Feng; Pan, Wen-Sheng; Zeng, Su

    2008-01-01

    AIM: To evaluate the patterns of use of clarithromycin for gastrointestinal disease treatment and promote its rational use. METHODS: Using a structured pro forma, we conducted a two-month survey of the electronic prescriptions containing immediate-release (IR) or sustained-release (SR) product of clarithromycin for outpatients with gastrointestinal diseases in a 2200-bed general hospital. Suitability of the prescription was audited retrospectively. RESULTS: One hundred and sixty-four prescriptions of SR product and 110 prescriptions of IR product were prescribed for gastrointestinal disease treatment. Among prescriptions for anti-Helicobacter pylori (H pylori) therapy, triple therapy take the dominant position (91.8%), followed by quadruple therapy (4.3%) and dual therapy (3.9%). Amoxicillin was the most frequently co-prescribed antibiotic. Furazolidone and levofloxacin are used more widely than metronidazole or tinidazole. Clarithromycin SR was administered at inappropriate time points in all prescriptions. Fifty percent of all prescriptions of clarithromycin SR, and 6.4% of prescriptions of clarithromycin IR, were prescribed at inappropriate dosing intervals. Surprisingly, disconcordance between diagnoses and indications was observed in all prescriptions of clarithromycin SR which has not been approved for treating H pylori infection although off-label use for this purpose was reported in literature. On the contrary, only one prescription (0.9%) of clarithromycin IR was prescribed for unapproved indication (i.e. gastro-oesophageal reflux disease). 1.4% of prescriptions for chronic gastritis or peptic ulcer treatment were irrational in that clarithromycin was not co-prescribed with gastric acid inhibitors. Clinical significant CYP3A based drug interactions with clarithromycin were identified. CONCLUSION: There is a great scope to improve the quality of clarithromycin prescribing in patients with gastrointestinal disease, especially with regard to administration

  14. Shifting the emphasis: From cost models to satellite utility or revenue models. The case for a value-centric mindset in space system design

    NASA Astrophysics Data System (ADS)

    Saleh, Joseph H.; Jordan, Nicole C.; Newman, Dava J.

    2007-11-01

    Cost models are pervasive throughout the aerospace industry. Almost every engineer or program manager in this industry is familiar with cost models or cost estimate relationships (CER), and has at some point in his or her career performed cost analyses for a system or a subsystem. This situation is the laudable result of the emphasis over the last two decades on financial discipline in the design of complex engineering systems. Unfortunately, while cost models are pervasive throughout the aerospace industry, revenue models or utility models on the other hand are quasi-inexistent. In this paper, we argue that while the proliferation of spacecraft cost models is laudable, the absence of interest in satellite utility or revenue models is deplorable. We contend that this situation carries a number of drawbacks. For example, the situation perhaps conveys the false impression that satellites are either cost sinks, or expensive artifacts whose value or utility profile over their design lifetime is difficult to quantify and does not warrant efforts to do so. More importantly, we argue that the absence of quantitative revenue models (in the case of commercial systems) or utility models (in the case of scientific or military systems) makes it difficult to build the case for such systems to policy-makers or decision-makers, especially in the light in their exorbitant costs. Furthermore, we show that the specification and selection of a system design lifetime will always have weak arguments fraught with subjectivity in the absence of quantitative revenue or utility models. We make the case that satellites, like other complex engineering systems, should be viewed as "value-delivery artifacts." Finally, we propose a roadmap for developing a spacecraft utility model in the case of a GEO communications satellite.

  15. Utility of magnetic resonance imaging in anorectal disease

    PubMed Central

    Berman, Loren; Israel, Gary M; McCarthy, Shirley M; Weinreb, Jeffrey C; Longo, Walter E

    2007-01-01

    Imaging of both benign and malignant anorectal diseases has traditionally posed a challenge to clinicians, and as a result history and physical exam have been relied on heavily. CT scanning and endorectal ultrasound have become popular in assessment of anatomy and staging of tumors, but have limitations. Magnetic resonance imaging (MRI) has the capability to fill in the gaps left open by more conventional imaging modalities and continues to be promising as the definitive imaging technique in the pelvis, especially with advancement of emerging technologies in this field. A comprehensive review of this topic has been undertaken. Anorectal disease is divided into three broad categories: cancer, fistula/abscess, and pelvic floor disorders. A review of the literature is performed to evaluate the use of MRI and other imaging modalities in these three areas. Preoperative imaging is useful in the evaluation of all three areas of anorectal disease. MRI is an effective tool in delineating anatomy and, when correlating with the specific clinical scenario, is an effective adjunct in clinical decision-making in order to optimize outcome. MRI continues to be a promising and novel approach to imaging various afflictions of the anorectum and the pelvic floor. Its role is more well-established in some areas than in others, and there are still significant limitations. As technology advances, MRI will shed more light on a complex anatomical area. PMID:17589891

  16. MicroRNAs Classify Different Disease Behavior Phenotypes of Crohn's Disease and May Have Prognostic Utility

    PubMed Central

    Peck, Bailey C. E.; Weiser, Matthew; Lee, Saangyoung E.; Gipson, Gregory R.; Iyer, Vishal B.; Sartor, Ryan B.; Herfarth, Hans H.; Long, Millie D.; Hansen, Jonathan J.; Isaacs, Kim L.; Trembath, Dimitri G.; Rahbar, Reza; Sadiq, Timothy S.

    2015-01-01

    Background: There is a dire need for reliable prognostic markers that can guide effective therapeutic intervention in Crohn's disease (CD). We examined whether different phenotypes in CD can be classified based on colonic microRNA (miRNA) expression and whether miRNAs have prognostic utility for CD. Methods: High-throughput sequencing of small and total RNA isolated from colon tissue from patients with CD and controls without Inflammatory Bowel Disease (non-IBD) was performed. To identify miRNAs associated with specific phenotypes of CD, patients were stratified according to disease behavior (nonstricturing, nonpenetrating; stricturing; penetrating), and miRNA profiles in each subset were compared with those of the non-IBD group. Validation assays were performed using quantitative reverse transcription polymerase chain reaction. These miRNAs were further evaluated by quantitative reverse transcriptase polymerase chain reaction on formalin-fixed, paraffin-embedded tissue (index biopsies) of patients with nonpenetrating CD at the time of diagnosis that either retained the nonpenetrating phenotype or progressed to penetrating/fistulizing CD. Results: We found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation. Furthermore, we also demonstrated that expression levels of miR-215 in index biopsies of patients with CD might predict the likelihood of progression to penetrating/fistulizing CD. Finally, using a novel statistical simulation approach applied to colonic RNA-sequencing data for patients with CD and non-IBD controls, we identified miR-31-5p and miR-203 as candidate master regulators of gene expression profiles associated with CD. Conclusions: miRNAs may serve as clinically useful prognostic markers guiding initial therapy and identifying patients who would benefit most from effective intervention. PMID:26164662

  17. Using Satellite Images of Environmental Changes to Predict Infectious Disease Outbreaks

    PubMed Central

    Colwell, Rita R.; Rose, Joan B.; Morse, Stephen S.; Rogers, David J.; Yates, Terry L.

    2009-01-01

    Recent events clearly illustrate a continued vulnerability of large populations to infectious diseases, which is related to our changing human-constructed and natural environments. A single person with multidrug-resistant tuberculosis in 2007 provided a wake-up call to the United States and global public health infrastructure, as the health professionals and the public realized that today’s ease of airline travel can potentially expose hundreds of persons to an untreatable disease associated with an infectious agent. Ease of travel, population increase, population displacement, pollution, agricultural activity, changing socioeconomic structures, and international conflicts worldwide have each contributed to infectious disease events. Today, however, nothing is larger in scale, has more potential for long-term effects, and is more uncertain than the effects of climate change on infectious disease outbreaks, epidemics, and pandemics. We discuss advances in our ability to predict these events and, in particular, the critical role that satellite imaging could play in mounting an effective response. PMID:19788799

  18. Utility of imaging for nutritional intervention studies in Alzheimer's disease.

    PubMed

    de Wilde, Martijn C; Kamphuis, Patrick J G H; Sijben, John W C; Scheltens, Phillip

    2011-09-01

    Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder and the leading cause of dementia, wherein synapse loss is the strongest structural correlate with cognitive impairment. Basic research has shown that dietary supply of precursors and co-factors for synthesis of neuronal membranes enhances the formation of synapses. Daily intake of a medical food containing a mix of these nutrients for 12 weeks in humans improved memory, measured as immediate and delayed verbal recall by the Wechsler Memory Scale-revised, in patients with very mild AD (MMSE 24-26). An improvement of immediate verbal recall was noted following 24 weeks of intervention in an exploratory extension of the study. These data suggest that the intervention may improve synaptic formation and function in early AD. Here we review emerging technologies that help identify changes in pathological hallmarks in AD, including synaptic function and loss of connectivity in the early stages of AD, before cognitive and behavioural symptoms are observable. These techniques include the detection of specific biomarkers in the cerebrospinal fluid, as well as imaging procedures such as fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET), amyloid PET, structural/functional magnetic resonance imaging, diffusion tensor imaging, magnetoencephalography (MEG) and electroencephalography (EEG). Such techniques can provide new insights into the functional and structural changes in the brain over time, and may therefore help to develop more effective AD therapies. In particular, nutritional intervention studies that target synapse formation and function may benefit from these techniques, especially FDG-PET and EEG/MEG employed in the preclinical or early stages of the disease. PMID:21816137

  19. New vegetation type map of India prepared using satellite remote sensing: Comparison with global vegetation maps and utilities

    NASA Astrophysics Data System (ADS)

    Roy, P. S.; Behera, M. D.; Murthy, M. S. R.; Roy, Arijit; Singh, Sarnam; Kushwaha, S. P. S.; Jha, C. S.; Sudhakar, S.; Joshi, P. K.; Reddy, Ch. Sudhakar; Gupta, Stutee; Pujar, Girish; Dutt, C. B. S.; Srivastava, V. K.; Porwal, M. C.; Tripathi, Poonam; Singh, J. S.; Chitale, Vishwas; Skidmore, A. K.; Rajshekhar, G.; Kushwaha, Deepak; Karnatak, Harish; Saran, Sameer; Giriraj, A.; Padalia, Hitendra; Kale, Manish; Nandy, Subrato; Jeganathan, C.; Singh, C. P.; Biradar, C. M.; Pattanaik, Chiranjibi; Singh, D. K.; Devagiri, G. M.; Talukdar, Gautam; Panigrahy, Rabindra K.; Singh, Harnam; Sharma, J. R.; Haridasan, K.; Trivedi, Shivam; Singh, K. P.; Kannan, L.; Daniel, M.; Misra, M. K.; Niphadkar, Madhura; Nagabhatla, Nidhi; Prasad, Nupoor; Tripathi, O. P.; Prasad, P. Rama Chandra; Dash, Pushpa; Qureshi, Qamer; Tripathi, S. K.; Ramesh, B. R.; Gowda, Balakrishnan; Tomar, Sanjay; Romshoo, Shakil; Giriraj, Shilpa; Ravan, Shirish A.; Behera, Soumit Kumar; Paul, Subrato; Das, Ashesh Kumar; Ranganath, B. K.; Singh, T. P.; Sahu, T. R.; Shankar, Uma; Menon, A. R. R.; Srivastava, Gaurav; Neeti; Sharma, Subrat; Mohapatra, U. B.; Peddi, Ashok; Rashid, Humayun; Salroo, Irfan; Krishna, P. Hari; Hajra, P. K.; Vergheese, A. O.; Matin, Shafique; Chaudhary, Swapnil A.; Ghosh, Sonali; Lakshmi, Udaya; Rawat, Deepshikha; Ambastha, Kalpana; Malik, Akhtar H.; Devi, B. S. S.; Gowda, Balakrishna; Sharma, K. C.; Mukharjee, Prashant; Sharma, Ajay; Davidar, Priya; Raju, R. R. Venkata; Katewa, S. S.; Kant, Shashi; Raju, Vatsavaya S.; Uniyal, B. P.; Debnath, Bijan; Rout, D. K.; Thapa, Rajesh; Joseph, Shijo; Chhetri, Pradeep; Ramachandran, Reshma M.

    2015-07-01

    A seamless vegetation type map of India (scale 1: 50,000) prepared using medium-resolution IRS LISS-III images is presented. The map was created using an on-screen visual interpretation technique and has an accuracy of 90%, as assessed using 15,565 ground control points. India has hitherto been using potential vegetation/forest type map prepared by Champion and Seth in 1968. We characterized and mapped further the vegetation type distribution in the country in terms of occurrence and distribution, area occupancy, percentage of protected area (PA) covered by each vegetation type, range of elevation, mean annual temperature and precipitation over the past 100 years. A remote sensing-amenable hierarchical classification scheme that accommodates natural and semi-natural systems was conceptualized, and the natural vegetation was classified into forests, scrub/shrub lands and grasslands on the basis of extent of vegetation cover. We discuss the distribution and potential utility of the vegetation type map in a broad range of ecological, climatic and conservation applications from global, national and local perspectives. We used 15,565 ground control points to assess the accuracy of products available globally (i.e., GlobCover, Holdridge's life zone map and potential natural vegetation (PNV) maps). Hence we recommend that the map prepared herein be used widely. This vegetation type map is the most comprehensive one developed for India so far. It was prepared using 23.5 m seasonal satellite remote sensing data, field samples and information relating to the biogeography, climate and soil. The digital map is now available through a web portal (http://bis.iirs.gov.in).

  20. Simultaneous precision positioning and vibration suppression of an intelligent composite satellite structure utilizing piezoelectric sensors and actuators

    NASA Astrophysics Data System (ADS)

    Doherty, Kathleen Marie

    Adaptive or intelligent structures which have the capability for sensing and responding to their environment promise a novel approach to satisfying the stringent performance requirements of future space missions. This research effort focuses on the development of a smart thruster mount truss structure with precision positioning and active vibration suppression capability for use in a space satellite. The smart thruster mount would utilize piezoelectric sensors and actuators for precision positioning to provide fine tuning of position tolerance for thruster alignment. The same structure may be used for suppressing the vibration that resonates throughout the spacecraft during thruster firing. This vibration renders sensitive optical or measurement equipment non-operational until the disturbance has dissipated. This smart system approach would greatly enhance mission performance by fine tuning attitude control, potentially eliminating the nonoperational period as well as minimizing fuel consumption utilized for position correction. The configuration of the smart thruster mount truss system is that of a modified Stewart platform. Precision positioning of the truss structure is achieved using active members which extend or contract to tilt the upper platform where the thruster is mounted. An inverse kinematic analysis of a modified Stewart platform has been developed and is used to determine the required axial displacement of the active struts for the desired angular tilt of the smart platform. Experimental data is used to verify the precision positioning capabilities of the active struts. This information demonstrates the ability of the active strut to tilt the top of the smart platform by the required angular displacement. Analytical verification of the vibration suppression capabilities of the active struts in the smart composite platform using finite element analysis is presented. A model of an active strut with surface mounted sensors/actuators was used to develop

  1. Health Care Utilization among Migrant Latino Farmworkers: The Case of Skin Disease

    ERIC Educational Resources Information Center

    Feldman, Steven R.; Vallejos, Quirina M.; Quandt, Sara A.; Fleischer, Alan B., Jr.; Schulz, Mark R.; Verma, Amit; Arcury, Thomas A.

    2009-01-01

    Context: Skin diseases are common occupational illnesses for migrant farmworkers. Farmworkers face many barriers in accessing health care resources. Purpose: Framed by the Health Behavior Model, the purpose of this study was to assess health care utilization for skin disease by migrant Latino farmworkers. Methods: Three hundred and four migrant…

  2. Molecular characterization of begomoviruses and DNA satellites associated with okra leaf curl disease in Cameroon.

    PubMed

    Leke, Walter N; Sattar, Muhammad N; Ngane, Emilia B; Ngeve, Jacob M; Kvarnheden, Anders; Brown, Judith K

    2013-06-01

    Okra leaf curl disease (OLCD) is the most important viral disease of okra in West Africa. In this study, a complex of begomoviruses and associated DNA satellites were identified in symptomatic okra plants from southwestern Cameroon. Sequence analyses showed that two of the plants (Lik1 and Njo5) were infected with a begomovirus being a recombinant of cotton leaf curl Gezira virus (CLCuGeV) and okra yellow crinkle virus (OYCrV). The recombinant genome shared highest nucleotide identity with isolates of CLCuGeV at 87.8% and is therefore considered to be member of a new begomovirus species, Okra leaf curl Cameroon virus (OLCuCMV). One plant (Mue5) was infected by a begomovirus with 95.8% nucleotide identy to CLCuGeV, while in the plants Lik1, Mue1 and Njo5, a begomovirus was identified showing highest nucleotide identity at 93.7% with OYCrV. The nucleotide comparisons and phylogenetic analyses suggest that these isolates represent new Cameroonian strains of CLCuGeV and OYCrV (CLCuGeV-CM and OYCrV-CM). Mixed infection of OLCuCMV and OYCrV-CM was found in two of the plants. A betasatellite and two divergent alphasatellites were also associated with the begomoviruses. The betasatellite was identified as cotton leaf curl Gezira betasatellite (CLCuGeB) with the highest nucleotide identity at 93.3% to other African isolates of CLCuGeB. The alphasatellites, herein named Alpha-1 and Alpha-2, shared 97.3% and 95.2% identity, respectively, with cotton leaf curl Gezira alphasatellite (CLCuGeA) and okra leaf curl Burkina Faso alphasatellite (OLCuBFA). These collective results emphasize the extent of diversity among okra-infecting begomovirus-satellite complexes in western Africa.

  3. Techniques for analyzing and utilizing the rain gauges at the NASA White Sands Test Facility. [Tracking and Data Relay Satellite System ground station

    NASA Technical Reports Server (NTRS)

    Kalagher, R. J.

    1973-01-01

    Ten tipping bucket rain gauges have been installed at the NASA WSTF for the purpose of determining rainfall characteristics in this area which may affect the performance of the NASA Tracking and Data Relay Satellite System. A plan is presented for analyzing and utilizing the data which will be obtained during the course of this experiment. Also included is a description of a computer program which has been written to aid in the analysis.

  4. Pathways of Polyunsaturated Fatty Acid Utilization: Implications for Brain Function in Neuropsychiatric Health and Disease

    PubMed Central

    Liu, Joanne J.; Green, Pnina; Mann, J. John; Rapoport, Stanley I.; Sublette, M. Elizabeth

    2014-01-01

    Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development and function. Abnormalities of PUFA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer’s disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUFA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUFA utilization, highlighting their relevance to neuropsychiatric disease. PMID:25498862

  5. Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.

    PubMed

    Liu, Joanne J; Green, Pnina; John Mann, J; Rapoport, Stanley I; Sublette, M Elizabeth

    2015-02-01

    Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development and function. Abnormalities of PUFA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer's disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUFA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUFA utilization, highlighting their relevance to neuropsychiatric disease.

  6. From scientific understanding to operational utility: New concepts and tools for monitoring space weather effects on satellites

    NASA Astrophysics Data System (ADS)

    Green, J. C.; Rodriguez, J. V.; Denig, W. F.; Redmon, R. J.; Blake, J. B.; Mazur, J. E.; Fennell, J. F.; O'Brien, T. P.; Guild, T. B.; Claudepierre, S. G.; Singer, H. J.; Onsager, T. G.; Wilkinson, D. C.

    2013-12-01

    NOAA space weather sensors have monitored the near Earth space radiation environment for more than three decades providing one of the only long-term records of these energetic particles that can disable satellites and pose a threat to astronauts. These data have demonstrated their value for operations for decades, but they are also invaluable for scientific discovery. Here we describe the development of new NOAA tools for assessing radiation impacts to satellites and astronauts working in space. In particular, we discuss the new system implemented for processing and delivering near real time particle radiation data from the POES/MetOp satellites. We also describe the development of new radiation belt indices from the POES/MetOp data that capture significant global changes in the environment needed for operational decision making. Lastly, we investigate the physical processes responsible for dramatic changes of the inner proton belt region and the potential consequences these new belts may have for satellite operations.

  7. Health Care Costs, Utilization and Patterns of Care following Lyme Disease

    PubMed Central

    Adrion, Emily R.; Aucott, John; Lemke, Klaus W.; Weiner, Jonathan P.

    2015-01-01

    Background Lyme disease is the most frequently reported vector borne infection in the United States. The Centers for Disease Control have estimated that approximately 10% to 20% of individuals may experience Post-Treatment Lyme Disease Syndrome – a set of symptoms including fatigue, musculoskeletal pain, and neurocognitive complaints that persist after initial antibiotic treatment of Lyme disease. Little is known about the impact of Lyme disease or post-treatment Lyme disease symptoms (PTLDS) on health care costs and utilization in the United States. Objectives 1) to examine the impact of Lyme disease on health care costs and utilization, 2) to understand the relationship between Lyme disease and the probability of developing PTLDS, 3) to understand how PTLDS may impact health care costs and utilization. Methods This study utilizes retrospective data on medical claims and member enrollment for persons aged 0-64 years who were enrolled in commercial health insurance plans in the United States between 2006-2010. 52,795 individuals treated for Lyme disease were compared to 263,975 matched controls with no evidence of Lyme disease exposure. Results Lyme disease is associated with $2,968 higher total health care costs (95% CI: 2,807-3,128, p<.001) and 87% more outpatient visits (95% CI: 86%-89%, p<.001) over a 12-month period, and is associated with 4.77 times greater odds of having any PTLDS-related diagnosis, as compared to controls (95% CI: 4.67-4.87, p<.001). Among those with Lyme disease, having one or more PTLDS-related diagnosis is associated with $3,798 higher total health care costs (95% CI: 3,542-4,055, p<.001) and 66% more outpatient visits (95% CI: 64%-69%, p<.001) over a 12-month period, relative to those with no PTLDS-related diagnoses. Conclusions Lyme disease is associated with increased costs above what would be expected for an easy to treat infection. The presence of PTLDS-related diagnoses after treatment is associated with significant health care

  8. Clinical Utility of Serologic Testing for Celiac Disease in Asymptomatic Patients

    PubMed Central

    2011-01-01

    Executive Summary Objective The objective of this evidence-based analysis was to evaluate the clinical utility of serologic testing for celiac disease in asymptomatic individuals presenting with one of the non-gastrointestinal conditions evaluated in this report. The clinical utility was based on the effects of a gluten-free diet (GFD) on outcomes specific to each of these conditions. The prevalence of celiac disease in asymptomatic individuals and one of these non-gastrointestinal conditions was also evaluated. Clinical Need and Target Population Celiac Disease Celiac disease is an autoimmune disease characterized by a chronic inflammatory state of the proximal small bowel mucosa accompanied by structural and functional changes. Technology Under Evaluation Serologic Tests for Celiac Disease There are a number of serologic tests for celiac disease available. Serologic tests are automated with the exception of the anti-endomysial antibody test, which is more time-consuming and operator-dependent than the other tests. Research Questions What is the prevalence of asymptomatic celiac disease in patients presenting with one of the non-gastrointestinal conditions evaluated? What is the effect of the gluten-free diet on condition-specific outcomes in patients with asymptomatic celiac disease presenting with one of the non-gastrointestinal conditions evaluated? What is the clinical utility of serologic testing for celiac disease in asymptomatic patients presenting with one of the non-gastrointestinal conditions evaluated? The clinical utility was defined as the impact of the GFD on disease specific outcomes. What is the risk of all-cause mortality and lymphoma in individuals with asymptomatic celiac disease? What is the budget impact of serologic testing for celiac disease in asymptomatic subjects presenting with one of the non-gastrointestinal conditions evaluated? Research Methods Study Population The study population consisted of individuals with newly diagnosed celiac

  9. Transgenic mice expressing human glucocerebrosidase variants: utility for the study of Gaucher disease.

    PubMed

    Sanders, Angela; Hemmelgarn, Harmony; Melrose, Heather L; Hein, Leanne; Fuller, Maria; Clarke, Lorne A

    2013-08-01

    Gaucher disease is an autosomal recessively inherited storage disorder caused by deficiency of the lysosomal hydrolase, acid β-glucosidase. The disease manifestations seen in Gaucher patients are highly heterogeneous as is the responsiveness to therapy. The elucidation of the precise factors responsible for this heterogeneity has been challenging as the development of clinically relevant animal models of Gaucher disease has been problematic. Although numerous murine models for Gaucher disease have been described each has limitations in their specific utility. We describe here, transgenic murine models of Gaucher disease that will be particularly useful for the study of pharmacological chaperones. We have produced stable transgenic mouse strains that individually express wild type, N370S and L444P containing human acid β-glucosidase and show that each of these transgenic lines rescues the lethal phenotype characteristic of acid β-glucosidase null mice. Both the N370S and L444P transgenic models show early and progressive elevations of tissue sphingolipids with L444P mice developing progressive splenic Gaucher cell infiltration. We demonstrate the potential utility of these new transgenic models for the study of Gaucher disease pathogenesis. In addition, since these mice produce only human enzyme, they are particularly relevant for the study of pharmacological chaperones that are specifically targeted to human acid β-glucosidase and the common mutations underlying Gaucher disease. PMID:23642305

  10. Utilization of Meteorological Satellite Imagery for World-Wide Environmental Monitoring the Lower Mississippi River Flood of 1979 - Case 1. [St. Louis, Missouri

    NASA Technical Reports Server (NTRS)

    Helfert, M. R.; Mccrary, D. G.; Gray, T. I. (Principal Investigator)

    1981-01-01

    The 1979 Lower Mississippi River flood was selected as a test case of environmental disaster monitoring utilizing NOAA-n imagery. A small scale study of the St. Louis Missouri area comparing ERTS-1 (LANDSAT) and NOAA-2 imagery and flood studies using only LANDSAT imagery for mapping the Rad River of the North, and Nimbus-5 imagery for East Australia show the nonmeteorological applications of NOAA satellites. While the level of NOAA-n imagery detail is not that of a LANDSAT image, for operational environmental monitoring users the NOAA-n imagery may provide acceptable linear resolution and spectral isolation.

  11. Satellite altimeters after Skylab and GEOS-C - should they utilize a single transmitter or an array of pulsed amplifiers?

    NASA Technical Reports Server (NTRS)

    Greene, A. H.; Hudson, E. F.

    1972-01-01

    An attempt was made to determine if future satellite altimeters, operating at K-band, should use a single transmitter or an array of pulsed amplifiers. The two systems were compared as a function of reliability, power, service life, system requirements, and weight. Preliminary results indicate the modular system to be superior in service life and reliability although it requires more power and is substantially heavier than the single system. No concrete conclusions were reached as to which system should be used.

  12. Earth Resources Technology Satellite (ERTS)

    NASA Technical Reports Server (NTRS)

    1971-01-01

    The Earth Resources Technology Satellite (ERTS) mock-up in a space chamber test at General Electric's Space Division. The ERTS program represented a concentrated effort to observe and monitor the limited resources of the Earth, in order to best conserve and utilize the resources in support of a burgeoning world population. The first ERTS was launched in 1972 and was later named Land Remote-Sensing Satellite (Landsat), to better represent the civil satellite program's prime emphasis on remote sensing of land resources. Multiple sensors survey and relay back masses of data in various ways from the Landsat. NASA has built 7 Land Remote Sensing Satellites, which have helped agricultural experts pick up underutilized land areas and new prospects for land use through irrigation. It has also assisted in pinpointing the spread of crop disease and in charting new uses of the sea for oceanographers.

  13. Health Care Utilization among Migrant Latino Farmworkers: The Case of Skin Disease

    PubMed Central

    Feldman, Steven R.; Vallejos, Quirina M.; Quandt, Sara A.; Fleischer, Alan B.; Schulz, Mark R.; Verma, Amit; Arcury, Thomas A.

    2009-01-01

    Context Skin diseases are common occupational illnesses for migrant farmworkers. Farmworkers face many barriers in accessing healthcare resources. Purpose Framed by the Health Behavior Model, the purpose of this study was to assess health care utilization for skin disease by migrant Latino farmworkers. Methods 304 migrant and seasonal Latino farmworkers in North Carolina were enrolled in a longitudinal study of skin disease and healthcare utilization over a single agricultural season. Self-reported and dermatologist-diagnosed skin condition data were collected at baseline and at up to four follow-up assessments. Medical visit rates were compared to national norms. Findings Self-reported skin problems and diagnosed skin disease were common among farmworkers. However, only 34 health care visits were reported across the entire agricultural season, and none of the visits were for skin diseases. Nevertheless, self-treatment for skin conditions was common, including use of non-prescription preparations (63%), prescription products (9%), and home remedies (6%). General medical office visits were reported in 3.2% of the assessments, corresponding to 1.6 office visits per person year. Conclusions The migrant farmworker population consists largely of young men who make little use of clinic services. Skin conditions are very common among these workers, but use of medical services for these conditions is not common. Instead, farmworkers rely primarily on self-treatment. Clinic-based studies of farmworker skin conditions will not account for most injury or disease in this population and have the potential for biased estimates. PMID:19166568

  14. Gene-based vaccines and immunotherapeutic strategies against neurodegenerative diseases: Potential utility and limitations.

    PubMed

    Kudrna, Jeremy J; Ugen, Kenneth E

    2015-01-01

    There has been a recent expansion of vaccination and immunotherapeutic strategies from controlling infectious diseases to the targeting of non-infectious conditions including neurodegenerative disorders. In addition to conventional vaccine and immunotherapeutic modalities, gene-based methods that express antigens for presentation to the immune system by either live viral vectors or non-viral naked DNA plasmids have been developed and evaluated. This mini-review/commentary summarizes the advantages and disadvantages, as well as the research findings to date, of both of these gene-based vaccination approaches in terms of how they can be targeted against appropriate antigens within the Alzheimer and Parkinson disease pathogenesis processes as well as potentially against targets in other neurodegenerative diseases. Most recently, the novel utilization of these viral vector and naked DNA gene-based technologies includes the delivery of immunoglobulin genes from established biologically active monoclonal antibodies. This modified passive immunotherapeutic strategy has recently been applied to deliver passive antibody immunotherapy against the pathologically relevant amyloid β protein in Alzheimer disease. The advantages and disadvantages of this technological application of gene-based immune interventions, as well as research findings to date are also summarized. In sum, it is suggested that further evaluation of gene based vaccines and immunotherapies against neurodegenerative diseases are warranted to determine their potential clinical utility.

  15. Maximizing the diagnostic utility of endoscopic biopsy in dogs and cats with gastrointestinal disease.

    PubMed

    Jergens, Albert E; Willard, Michael D; Allenspach, Karin

    2016-08-01

    Flexible endoscopy has become a valuable tool for the diagnosis of many small animal gastrointestinal (GI) diseases, but the techniques must be performed carefully so that the results are meaningful. This article reviews the current diagnostic utility of flexible endoscopy, including practical/technical considerations for endoscopic biopsy, optimal instrumentation for mucosal specimen collection, the correlation of endoscopic indices to clinical activity and to histopathologic findings, and new developments in the endoscopic diagnosis of GI disease. Recent studies have defined endoscopic biopsy guidelines for the optimal number and quality of diagnostic specimens from different regions of the gut. They also have shown the value of ileal biopsy in the diagnosis of canine and feline chronic enteropathies, and have demonstrated the utility of endoscopic biopsy specimens beyond routine hematoxylin and eosin histopathological analysis, including their use in immunohistochemical, microbiological, and molecular studies. PMID:27387727

  16. Perceived Health Status and Utilization of Specialty Care: Racial and Ethnic Disparities in Patients with Chronic Diseases

    ERIC Educational Resources Information Center

    Glover, Saundra; Bellinger, Jessica D.; Bae, Sejong; Rivers, Patrick A.; Singh, Karan P.

    2010-01-01

    Objective: The objective of this study is to determine racial and ethnic variations in specialty care utilization based on (a) perceived health status and (b) chronic disease status. Methods: Variations in specialty care utilization, by perceived health and chronic disease status, were examined using the Commonwealth Fund Health Care Quality…

  17. The clinical utility of ultrasonography for rotator cuff disease, shoulder impingement syndrome and subacromial bursitis.

    PubMed

    Awerbuch, Mark S

    2008-01-01

    Periarticular shoulder disorders are common in clinical practice, and diagnosis is often difficult. Medicare statistics indicate that between 2001 and 2006 the use of diagnostic shoulder ultrasonography increased significantly. Rotator cuff disease, shoulder impingement syndrome and subacromial bursitis are among the most common diagnoses reported on shoulder ultrasonography. Shoulder ultrasonography is useful in the diagnosis of full thickness tears, but its utility for other rotator cuff disorders, shoulder impingement syndrome and subacromial bursitis is less well established. PMID:18205566

  18. Analysis of nuclear propagation effects utilizing wideband satellite data. Final report, 14 January 1980-30 January 1981

    SciTech Connect

    Rino, C.L.; Owen, J.; Livingston, R.C.

    1981-04-01

    Previous analyses of the Wideband Satellite data have emphasized the scale-size regime between 500 m and several tens of kilometers. In this report we describe the results of a detailed analysis of the auroral and equatorial total electron content (TEC) structure associated with the various scintillation phenomena. A nighttime equatorial anomaly was a prominent feature in the equatorial data, particularly as the solar cycle maximum approached. In the auroral data we found that an enhanced F region is the primary contributor to steep latitudinal TEC gradients. Because recent data have shown an abrupt steepening of the irregularity spectral density function near 500 m, a careful analysis of the mutual coherence function was performed to see if this feature could be detected in the Wideband scintillation data. The analysis did indeed reveal such a feature, which is evidently a permanent characteristic of the most severely disturbed equatorial irregularity continuum.

  19. Utilizing low-cost 3U single-sensor satellites for intelligence, surveillance, and reconnaissance mission capabilities

    NASA Astrophysics Data System (ADS)

    Huang, Philip M.; Knuth, Andrew A.; Garrison-Darrin, Margaret A.

    2012-06-01

    Leveraging low cost launch carriers for small satellites with the functionality required for DoD and intelligence missions realizes a hidden potential capability. The Multi-Mission Bus Demonstration (MBD) is a Johns Hopkins University Applied Physics Laboratory (JHU/APL) program to demonstrate military operational relevance in a 3U CubeSat form factor. The MBD spacecraft caters to mission versatility and responsive launch capabilities with a standardized bus and interchangeable payload interface design. MBD embraced the challenge of building two space vehicles on an extremely aggressive timeline and demanding budget, causing the development team to evaluate every step of the process to maximize efforts with minimal manpower and cost. MBD is providing a classified DoD payload capability that is truly operationally relevant and may revolutionize the mission area. As a single instrument or payload satellite, also called a SensorSat, MBD is a spacecraft of realizable ISR benefits including effective remote sensing, simplified engineering design and program requirements, and reduced time to launch, all yielding an appealing cost per unit. The SensorSat has potential to detect sufficient information that will act as a complementary component to tactical commanders in heightening battlefield awareness. Recent advancements in technology has put capabilities such as precision navigation, communication intelligence, signal intelligence, tactical warning, environmental intelligence, and a wide variety of ground imaging, at the tip of culmination in a small, economical package. This paper reviews the high functionality of the MBD spacecraft in the miniaturized footprint of 10 cm by 10 cm by 30cm which allows the mission to leverage inexpensive launch opportunities.

  20. Assessing the Utility of Satellite Imagery with Differing Spatial Resolutions for Deriving Proxy Measures of Slum Presence in Accra, Ghana

    PubMed Central

    Stoler, Justin; Daniels, Dean; Weeks, John R.; Stow, Douglas A.; Coulter, Lloyd L.; Finch, Brian Karl

    2012-01-01

    Little research has been conducted on how differing spatial resolutions or classification techniques affect image-driven identification and categorization of slum neighborhoods in developing nations. This study assesses the correlation between satellite-derived land cover and census-derived socioeconomic variables in Accra, Ghana to determine whether the relationship between these variables is altered with a change in spatial resolution or scale. ASTER and Landsat TM satellite images are each used to classify land cover using spectral mixture analysis (SMA), and land cover proportions are summarized across Enumeration Areas in Accra and compared to socioeconomic data for the same areas. Correlation and regression analyses compare the SMA results with a Slum Index created from various socio-economic data taken from the Census of Ghana, as well as to data derived from a “hard” per-pixel classification of a 2.4 m Quickbird image. Results show that the vegetation fraction is significantly correlated with the Slum Index (Pearson’s r ranges from −0.33 to −0.51 depending on which image-derived product is compared), and the use of a spatial error model improves results (multivariate model pseudo-R2 ranges from 0.37 to 0.40 by image product). We also find that SMA products derived from ASTER are a sufficient substitute for classification products derived from higher spatial resolution QB data when using land cover fractions as a proxy for slum presence, suggesting that SMA might be more cost-effective for deriving land cover fractions than the use of high-resolution imagery for this type of demographic analysis. PMID:23847453

  1. Patterns of cerebral glucose utilization in depression, multiple infarct dementia, and Alzheimer's disease

    SciTech Connect

    Kuhl, D.E.; Metter, E.J.; Riege, W.H.

    1983-01-01

    Patterns of local cerebral glucose utilization were determined in moderately to severely disabled patients with depression (n=7), multiple infarct dementia (n=6), and Alzheimer's disease (n=6), and in normal controls (n=6), using positron emission tomography with the /sup 18/F-fluorodeoxyglucose method. Average global metabolic rate was decreased 30% in patients with Alzheimer's disease, but overlap among the other groups reduced the discriminant value of this measure. In depressed patients, the cerebral metabolic pattern was normal, except for evidence of hypometabolic zone in the posterior-inferior frontal cortex which was of marginal statistical significance. In multiple infarct dementia, focal metabolic defects were scattered throughout the brain and exceeded the extent of infarction. In Alzheimer's disease, metabolism was markedly reduced in cortex, especially parietal cortex, but relatively preserved in caudate, thalamus, anterior cingulate gyrus, pre and post central gyrus, and calcarine occipital cortex, a pattern duplicating the degree and location of pathological and neurochemical alterations characteristic of this disorder.

  2. Clinical utility of (18)F-fluoride PET/CT in benign and malignant bone diseases.

    PubMed

    Li, Yuxin; Schiepers, Christiaan; Lake, Ralph; Dadparvar, Simin; Berenji, Gholam R

    2012-01-01

    (18)F labeled sodium fluoride is a positron-emitting, bone seeking agent with more favorable skeletal kinetics than conventional phosphate and diphosphonate compounds. With the expanding clinical usage of PET/CT, there is renewed interest in using (18)F-fluoride PET/CT for imaging bone diseases. Growing evidence indicates that (18)F fluoride PET/CT offers increased sensitivity, specificity, and diagnostic accuracy in evaluating metastatic bone disease compared to (99m)Tc based bone scintigraphy. National Oncologic PET Registry (NOPR) has expanded coverage for (18)F sodium fluoride PET scans since February 2011 for the evaluation of osseous metastatic disease. In this article, we reviewed the pharmacological characteristics of sodium fluoride, as well as the clinical utility of PET/CT using (18)F-fluoride in both benign and malignant bone disorders.

  3. Generation of a conditional knockout of murine glucocerebrosidase: utility for the study of Gaucher disease.

    PubMed

    Sinclair, Graham B; Jevon, Gareth; Colobong, Karen E; Randall, Derrick R; Choy, Francis Y M; Clarke, Lorne A

    2007-02-01

    Gaucher disease is a disorder of sphingolipid metabolism resulting from an inherited deficiency of the lysosomal hydrolase glucocerebrosidase. Affected individuals present with a spectrum of clinical symptoms ranging from hepatosplenomegaly, haematological abnormalities, and bone pain in type 1 disease, to severe neurodegeneration and premature death in types 2 and 3 disease. Although the basic biochemical defect is well characterized, there remains a poor understanding of the underlying pathophysiology of disease. In vitro studies suggest that macrophage glucocerebroside storage leads to tissue dysfunction through complex mechanisms involving altered intracellular calcium homeostasis and apoptosis. In order to study the pathogenic roles of these complex interactions, a viable animal model for Gaucher disease is needed. The complexity of this single gene disorder has been emphasized by the varied results of previous murine Gaucher models, ranging from perinatal lethality to phenotypically and biochemically asymptomatic animals. Recognizing the need to modulate the biochemical phenotype in mice to produce a relevant model, we have created a murine strain with key exons of the glucocerebrosidase gene flanked by loxP sites. We show that expression of Cre-recombinase in cells of hematopoietic and endothelial origin results in deficiency of glucocerebrosidase in the liver, spleen, bone marrow, and peripheral white cells. Glucocerebroside storage in this model leads to progressive splenomegaly with Gaucher cell infiltration and modest storage in the liver by 26 weeks of age. These results indicate the utility of this loxP GBA targeted murine strain for understanding the complex pathophysiology of Gaucher disease.

  4. Bayesian probability analysis: a prospective demonstration of its clinical utility in diagnosing coronary disease

    SciTech Connect

    Detrano, R.; Yiannikas, J.; Salcedo, E.E.; Rincon, G.; Go, R.T.; Williams, G.; Leatherman, J.

    1984-03-01

    One hundred fifty-four patients referred for coronary arteriography were prospectively studied with stress electrocardiography, stress thallium scintigraphy, cine fluoroscopy (for coronary calcifications), and coronary angiography. Pretest probabilities of coronary disease were determined based on age, sex, and type of chest pain. These and pooled literature values for the conditional probabilities of test results based on disease state were used in Bayes theorem to calculate posttest probabilities of disease. The results of the three noninvasive tests were compared for statistical independence, a necessary condition for their simultaneous use in Bayes theorem. The test results were found to demonstrate pairwise independence in patients with and those without disease. Some dependencies that were observed between the test results and the clinical variables of age and sex were not sufficient to invalidate application of the theorem. Sixty-eight of the study patients had at least one major coronary artery obstruction of greater than 50%. When these patients were divided into low-, intermediate-, and high-probability subgroups according to their pretest probabilities, noninvasive test results analyzed by Bayesian probability analysis appropriately advanced 17 of them by at least one probability subgroup while only seven were moved backward. Of the 76 patients without disease, 34 were appropriately moved into a lower probability subgroup while 10 were incorrectly moved up. We conclude that posttest probabilities calculated from Bayes theorem more accurately classified patients with and without disease than did pretest probabilities, thus demonstrating the utility of the theorem in this application.

  5. Distributed land surface modeling with utilization of multi-sensor satellite data: application for the vast agricultural terrain in cold region

    NASA Astrophysics Data System (ADS)

    Muzylev, E.; Uspensky, A.; Gelfan, A.; Startseva, Z.; Volkova, E.; Kukharsky, A.; Romanov, P.; Alexandrovich, M.

    2012-04-01

    A technique for satellite-data-based modeling water and heat regimes of a large scale area has been developed and applied for the 227,300 km2 agricultural region in the European Russia. The core component of the technique is the physically based distributed Remote Sensing Based Land Surface Model (RSBLSM) intended for simulating transpiration by vegetation and evaporation from bare soil, vertical transfer of water and heat within soil and vegetation covers during a vegetation season as well as hydrothermal processes in soil and snow covers during a cold season, including snow accumulation and melt, dynamics of soil moisture and temperature during soil freezing and thawing, infiltration into frozen soil. Processes in the "atmosphere-snow-frozen soil" system are critical for cold region agriculture, as they control crop development in early spring before the vegetation season beginning. For assigning the model parameters as well as for preliminary calibrating and validating the model, available multi-year data sets of soil moisture/temperature profiles, evaporation, snow and soil freezing depth measured at the meteorological stations located within the study region have been utilized. To provide an appropriate parametrization of the model for the areas where ground-based measurements are unavailable, estimates have been utilized for vegetation, meteorological and snow characteristics derived from the multispectral measurements of AVHRR/NOAA (1999-2010), MODIS/EOS Terra & Aqua (2002-2010), AMSR-E/Aqua (2003-2004; 2008-2010), and SEVIRI/Meteosat-9 (2009-2010). The technologies of thematic processing the listed satellite data have been developed and applied to estimate the land surface and snow cover characteristics for the study area. The developed technologies of AVHRR data processing have been adapted to retrieve land surface temperature (LST) and emissivity (E), surface-air temperature at a level of vegetation cover (TA), normalized vegetation index (NDVI), leaf

  6. Oral Disease Burden and Utilization of Dental Care Patterns Among Pediatric Solid Organ Transplant Recipients

    PubMed Central

    Shiboski, Caroline H.; Kawada, Phyllis; Golinveaux, Megan; Tornabene, Ann; Krishnan, Sumathi; Mathias, Robert; Besten, Pamela Den; Rosenthal, Philip

    2012-01-01

    Objectives We conducted a study among pediatric renal (RTRs) and liver transplant recipients (LTRs) to determine: a) the overall burden of oral disease; and b) the frequency with which this population utilizes dental care services in relation to sociodemographic factors and oral disease burden. Methods In this cross-sectional survey, study procedures included the completion of a standardized questionnaire (by parents/guardians), oral mucosal examination, assessment of caries, gingival enlargement, and plaque index. Results The 142 children (82 RTRs and 60 LTRs) enrolled from April 2002 to November 2005 were predominantly Latino (41 percent) and Caucasian (34 percent). Forty-three percent had at least one carious surface (in either a deciduous or permanent tooth), 19 percent had five or more carious surfaces, and 25 percent had gingival enlargement. We found only one case of oral candidiasis. Even though 72 percent of parents/guardians reported their child had a regular source of dental care, only 49 percent had a dental cleaning and 44 percent had dental radiographs in the past year, reflecting a low prevalence of preventive dental care. Among children with no regular source of dental care, there were statistically significantly higher proportions of Latinos, younger children, and families with an annual household income <$35,000. Conclusion While the prevalence of oral mucosal disease and gingival enlargement was low, the prevalence of children with caries was high, and there was low use of preventive dental care. Strategies to improve this population's utilization of preventive dental care are needed. PMID:18662252

  7. Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis.

    PubMed

    Platt, Thomas L; Reeves, Valerie L; Murphy, M Paul

    2013-09-01

    Animal models have been used for decades in the Alzheimer's disease (AD) research field and have been crucial for the advancement of our understanding of the disease. Most models are based on familial AD mutations of genes involved in the amyloidogenic process, such as the amyloid precursor protein (APP) and presenilin 1 (PS1). Some models also incorporate mutations in tau (MAPT) known to cause frontotemporal dementia, a neurodegenerative disease that shares some elements of neuropathology with AD. While these models are complex, they fail to display pathology that perfectly recapitulates that of the human disease. Unfortunately, this level of pre-existing complexity creates a barrier to the further modification and improvement of these models. However, as the efficacy and safety of viral vectors improves, their use as an alternative to germline genetic modification is becoming a widely used research tool. In this review we discuss how this approach can be used to better utilize common mouse models in AD research. This article is part of a Special Issue entitled: Animal Models of Disease.

  8. Computers and small satellites: How FORTE is utilizing the WWW as a {open_quotes}paperless{close_quotes} information resource and the development of a unique resource management planning tool

    SciTech Connect

    Roussel-Dupre, D.; Carter, M.; Franz, R.

    1997-10-01

    The Fast-On-orbit Recording of Transient Events (FORTE) satellite is the second satellite to be developed and flown by Los Alamos National Laboratory and is scheduled to be launched August, 1997 by a Pegasus XL rocket. FORTE follows in the footsteps of the ALEXIS satellite in utilizing a very small operations crew for mission operations. Partially based upon the ALEXIS automation and World Wide Web (WWW) usage for data dissemination, FORTE began at an early stage of ground processing to use the web as a repository of information about all aspects of the satellite. Detailed descriptions of the various satellite and experiment components, cable diagrams, integration photographs as well as extensive test data have all been compiled into a single site as a means of archiving the data at a single location. In this manner, it is readily available during times of ground testing, ground station operation training as well as anomaly resolution. Small satellites usually require extensive effort to optimize operation under minimal resources. For the FORTE satellite, a unique planning tool has been developed over the past 2 years which balances the various resources of the satellite (power, memory, downlink, on board command buffer, etc.) to provide the maximum data acquisition. This paper will concentrate on a description of both the extensive web interface and the planning tool. 6 refs.

  9. Utilizing a Multi-sensor Satellite Time Series in Real-time Drought Monitoring Across the United States

    NASA Astrophysics Data System (ADS)

    Brown, J. F.; Miura, T.; Gu, Y.; Jenkerson, C.; Wardlow, B.

    2009-05-01

    Drought events frequently occur in the United States and result in billions of dollars of damage, often exceeding the costs of other weather-related hazards. Monitoring drought conditions is a necessary function of government agencies at State, Federal, and local levels as part of decision support for planning, risk management, and hazard mitigation activities. In partnership with the National Drought Mitigation Center, the National Aeronautics and Space Administration, the U.S. Department of Agriculture Risk Management Agency, and the High Plains Regional Climate Center, the U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center is developing an operational drought decision support tool with relatively higher spatial resolution (1 km2) than traditional drought monitoring maps. The Vegetation Drought Response Index (VegDRI) is a geospatial model that integrates in-situ climate, satellite, and biophysical data, providing an indicator of canopy vegetation condition (or stress). The satellite data ingested into VegDRI are collected from daily polar-orbiting earth observing systems including the Advanced Very High Resolution Radiometer (AVHRR) and the Moderate Resolution Imaging Spectroradiometer (MODIS). These instruments provide regular synoptic measurements of land surface conditions in near-real time. In VegDRI, remote sensing data provide proxy information about the vegetation status (or health) related to climate-induced changes and are integrated with traditional drought indices based on in-situ climate observations. When merged, the two complementary sources of drought-related data provide a comprehensive and detailed picture of drought impacts across the landscape. A 20-year history of AVHRR time-series data produced over the U.S. at a 1 km2 resolution provides a historical context for monitoring drought conditions. However, the MODIS instrument has improved sensor characteristics designed for land surface monitoring. To seamlessly

  10. Roles and interactions of begomoviruses and satellite DNAs associated with okra leaf curl disease in Mali, West Africa.

    PubMed

    Kon, Tatsuya; Rojas, Maria R; Abdourhamane, Issoufou K; Gilbertson, Robert L

    2009-04-01

    Okra leaf curl disease (OLCD) is a major constraint on okra (Abelmoschus esculentus) production in West Africa. Two monopartite begomoviruses (okra virus-1 and okra virus-2), a betasatellite and a DNA1 satellite are associated with OLCD in Mali. Okra virus-1 is an isolate of okra yellow crinkle virus (OYCrV), okra virus-2 is a recombinant isolate of cotton leaf curl Gezira virus (CLCuGV) and the betasatellite is a variant of cotton leaf curl Gezira betasatellite (CLCuGB). Cloned DNA of OYCrV and CLCuGV were infectious and induced leaf curl symptoms in Nicotiana benthamiana plants, but did not induce OLCD in okra. However, when these clones were individually co-inoculated with the cloned CLCuGB DNA, symptom severity and viral DNA levels were increased in N. benthamiana plants and typical OLCD symptoms were induced in okra. The CLCuGB was also replicated by, and increased symptom severity of, three monopartite tomato-infecting begomoviruses, including two from West Africa. The sequence of the DNA1 satellite was highly divergent, indicating that it represents a distinct West African lineage. DNA1 replicated autonomously, and replication required the DNA1-encoded Rep protein. Although DNA1 reduced helper begomovirus DNA levels, symptoms were not attenuated. In the presence of CLCuGB, DNA levels of the helper begomoviruses and DNA1 were substantially increased. Together, these findings establish that OLCD in Mali is caused by a complex of monopartite begomoviruses and a promiscuous betasatellite with an associated parasitic DNA1 satellite. These findings are discussed in terms of the aetiology of OLCD and the evolution of new begomovirus/satellite DNA complexes.

  11. A cost utility analysis of treatment options for gallstone disease: methodological issues and results.

    PubMed

    Cook, J; Richardson, J; Street, A

    1994-01-01

    The techniques of cost utility analysis (CUA) were used to evaluate the treatment of gallstone disease by open and laparoscopic cholecystectomy and by extracorporeal shockwave lithotripsy (ESWL). The application of the techniques in this context raised three methodological questions which are not satisfactorily resolved in the literature. The first is whether an ex ante or ex post perspective is best adopted for the measurement of quality of life (QoL). The second is the method for converting a short term deterioration in QoL followed by full health into QALYs and the reliability of the methods available. The third is the issue of indirect costs which, in the context of a temporary disease state, cannot be easily avoided. The economic evaluation found laparoscopic cholecystectomy to be generally superior than the competitor technologies (entailing lower costs and better outcomes). However, the results were sensitive to assumptions about the perspective for measuring benefits and the inclusion of indirect costs.

  12. The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases

    PubMed Central

    Tao, Ye; Geng, Lei; Xu, Wei-Wei; Qin, Li-Min; Peng, Guang-Hua; Huang, Yi-Fei

    2016-01-01

    Hydrogen, one of the most well-known natural molecules, has been used in numerous medical applications owing to its ability to selectively neutralize cytotoxic reactive oxygen species and ameliorate hazardous inflammations. Hydrogen can exert protective effects on various reactive oxygen species-related diseases, including the transplantation-induced intestinal graft injury, chronic inflammation, ischemia–reperfusion injuries, and so on. Especially in the eye, hydrogen has been used to counteract multiple ocular pathologies in the ophthalmological models. Herein, the ophthalmological utilizations of hydrogen are systematically reviewed and the underlying mechanisms of hydrogen-induced beneficial effects are discussed. It is our hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich our pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases. PMID:27279745

  13. Attitudes regarding utilization of artificial insemination by donor in Huntington disease.

    PubMed

    McCormack, M K; Leiblum, S; Lazzarini, A

    1983-01-01

    We report on a study of attitudes toward artificial insemination by donor (AID) of persons at risk for Huntington disease (HD). The subjects of the study were 91 at risk persons and 68 matched controls. Both groups were divided by sex and age (45 yr less than or equal to vs greater than or equal to 46 yr). Demographic data included age, occupation, marital status, religion, education, ethnic background, and family size. We recorded 1) attitudes toward reproduction, 2) nature of contact with affected family member(s), 3) effects of HD on family planning, 4) attitudes toward AID, and 5) concern about donor selection criteria. Results suggest that 1) men and women differ in several ways with regard to their views about AID, and 2) that more vigorous educational programs might increase utilization of AID for the prevention of not only HD, but other human genetic diseases as well. PMID:6219582

  14. Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases.

    PubMed

    Al-Jaderi, Zaidoon; Maghazachi, Azzam A

    2016-01-01

    Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl fumarate (DMF) is utilized as an oral drug to treat this disease and is proven to be potent with less side effects than several other drugs. On the other hand, monomethyl fumarate (MMF), a related compound, has not been examined in greater details although it has the potential as a therapeutic drug for MS and other diseases. The mechanism of action of DMF or MMF is related to their ability to enhance the antioxidant pathways and to inhibit reactive oxygen species. However, other mechanisms have also been described, which include effects on monocytes, dendritic cells, T cells, and natural killer cells. It is also reported that DMF might be useful for treating psoriasis, asthma, aggressive breast cancers, hematopoeitic tumors, inflammatory bowel disease, intracerebral hemorrhage, osteoarthritis, chronic pancreatitis, and retinal ischemia. In this article, we will touch on some of these diseases with an emphasis on the effects of DMF and MMF on various immune cells. PMID:27499754

  15. Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases

    PubMed Central

    Al-Jaderi, Zaidoon; Maghazachi, Azzam A.

    2016-01-01

    Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl fumarate (DMF) is utilized as an oral drug to treat this disease and is proven to be potent with less side effects than several other drugs. On the other hand, monomethyl fumarate (MMF), a related compound, has not been examined in greater details although it has the potential as a therapeutic drug for MS and other diseases. The mechanism of action of DMF or MMF is related to their ability to enhance the antioxidant pathways and to inhibit reactive oxygen species. However, other mechanisms have also been described, which include effects on monocytes, dendritic cells, T cells, and natural killer cells. It is also reported that DMF might be useful for treating psoriasis, asthma, aggressive breast cancers, hematopoeitic tumors, inflammatory bowel disease, intracerebral hemorrhage, osteoarthritis, chronic pancreatitis, and retinal ischemia. In this article, we will touch on some of these diseases with an emphasis on the effects of DMF and MMF on various immune cells. PMID:27499754

  16. The Impact of Obesity on Perioperative Resource Utilization after Elective Spine Surgery for Degenerative Disease.

    PubMed

    Planchard, Ryan F; Higgins, Dominique M; Mallory, Grant W; Puffer, Ross C; Jacob, Jeffrey T; Curry, Timothy B; Kor, Daryl J; Clarke, Michelle J

    2015-08-01

    Study Design Retrospective case series. Objective To determine the effect of obesity on the resource utilization and cost in 3270 consecutive patients undergoing elective noninstrumented decompressive surgeries for degenerative spine disease at Mayo Clinic Rochester between 2005 and 2012. Methods Groups were assessed for baseline differences (age, gender, and American Society of Anesthesiologists [ASA] classification, procedure type, and number of operative levels). Outcome variables included the transfusion requirements during surgery, the total anesthesia and surgical times, intensive care unit (ICU) admissions, standardized costs, as well as the ICU and hospital length of stay (LOS). Regression analysis was used to evaluate for strength of association between obesity and outcome variables. Results Baseline differences between the groups (nonobese: n = 1,853; obese: n = 1,417) were found with respect to age, ASA class, gender, procedure type, and number of operative levels. After correcting for differences, we found significant associations between obesity and surgical (p < 0.0001) and anesthesia times (p < 0.0001) and hospital LOS (p < 0.0001). Additionally, ICU admission rates (p = 0.02) and requirement for postoperative ventilation (p = 0.048) were significantly higher in obese patients. Finally, mean difference in total cost ($1,632, p < 0.0001) was significantly higher for the obese cohort. Conclusion Obesity is associated with increased resource utilization and cost in patients undergoing a noninstrumented decompressive surgery for degenerative spine disease.

  17. Evaluating the Utility of Satellite Soil Moisture Retrievals over Irrigated Areas and the Ability of Land Data Assimilation Methods to Correct for Unmodeled Processes

    NASA Technical Reports Server (NTRS)

    Kumar, S. V.; Peters-Lidard, C. D.; Santanello, J. A.; Reichle, R. H.; Draper, C. S.; Koster, R. D.; Nearing, G.; Jasinski, M. F.

    2015-01-01

    Earth's land surface is characterized by tremendous natural heterogeneity and human-engineered modifications, both of which are challenging to represent in land surface models. Satellite remote sensing is often the most practical and effective method to observe the land surface over large geographical areas. Agricultural irrigation is an important human-induced modification to natural land surface processes, as it is pervasive across the world and because of its significant influence on the regional and global water budgets. In this article, irrigation is used as an example of a human-engineered, often unmodeled land surface process, and the utility of satellite soil moisture retrievals over irrigated areas in the continental US is examined. Such retrievals are based on passive or active microwave observations from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E), the Advanced Microwave Scanning Radiometer 2 (AMSR2), the Soil Moisture Ocean Salinity (SMOS) mission, WindSat and the Advanced Scatterometer (ASCAT). The analysis suggests that the skill of these retrievals for representing irrigation effects is mixed, with ASCAT-based products somewhat more skillful than SMOS and AMSR2 products. The article then examines the suitability of typical bias correction strategies in current land data assimilation systems when unmodeled processes dominate the bias between the model and the observations. Using a suite of synthetic experiments that includes bias correction strategies such as quantile mapping and trained forward modeling, it is demonstrated that the bias correction practices lead to the exclusion of the signals from unmodeled processes, if these processes are the major source of the biases. It is further shown that new methods are needed to preserve the observational information about unmodeled processes during data assimilation.

  18. Evaluating the utility of satellite soil moisture retrievals over irrigated areas and the ability of land data assimilation methods to correct for unmodeled processes

    NASA Astrophysics Data System (ADS)

    Kumar, S. V.; Peters-Lidard, C. D.; Santanello, J. A.; Reichle, R. H.; Draper, C. S.; Koster, R. D.; Nearing, G.; Jasinski, M. F.

    2015-11-01

    Earth's land surface is characterized by tremendous natural heterogeneity and human-engineered modifications, both of which are challenging to represent in land surface models. Satellite remote sensing is often the most practical and effective method to observe the land surface over large geographical areas. Agricultural irrigation is an important human-induced modification to natural land surface processes, as it is pervasive across the world and because of its significant influence on the regional and global water budgets. In this article, irrigation is used as an example of a human-engineered, often unmodeled land surface process, and the utility of satellite soil moisture retrievals over irrigated areas in the continental US is examined. Such retrievals are based on passive or active microwave observations from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E), the Advanced Microwave Scanning Radiometer 2 (AMSR2), the Soil Moisture Ocean Salinity (SMOS) mission, WindSat and the Advanced Scatterometer (ASCAT). The analysis suggests that the skill of these retrievals for representing irrigation effects is mixed, with ASCAT-based products somewhat more skillful than SMOS and AMSR2 products. The article then examines the suitability of typical bias correction strategies in current land data assimilation systems when unmodeled processes dominate the bias between the model and the observations. Using a suite of synthetic experiments that includes bias correction strategies such as quantile mapping and trained forward modeling, it is demonstrated that the bias correction practices lead to the exclusion of the signals from unmodeled processes, if these processes are the major source of the biases. It is further shown that new methods are needed to preserve the observational information about unmodeled processes during data assimilation.

  19. The antioxidative function, preventive action on disease and utilization of proanthocyanidins.

    PubMed

    Ariga, Toshiaki

    2004-01-01

    Proanthocyanidins, which belong to a class of polyphenols, are widely distributed throughout the plant kingdom. Most people ingest trace amounts of proanthocyanidins through foods such as red wine and cranberry juice. However, the functional properties of proanthocyanidins have been little understood. Since 1983, we have studied the antioxidative functions, preventive actions on diseases and utilization of proanthocyanidins. The antioxidative activities of proanthocyanidins were found to be much stronger than vitamin C or vitamin E in aqueous systems. The mechanisms for their antioxidative actions were shown to involve radical scavenging, quenching, and enzyme-inhibiting actions. The preventive actions of proanthcyanidins on diseases relating to reactive oxygen species was examined using animal tests. Proanthocyanidin-rich grape seed extract was showed to have preventive actions on diseases such as atherosclerosis, gastric ulcer, large bowel cancer, cataracts and diabetes. In human intervention trials, grape seed extract was shown to have preventive effects on the increase in lipid peroxides in human plasma after exercise and on muscle fatigue after training. The uses and manufacturing techniques of proanthocyanidin products were subsequently developed. The products were launched as antioxidants in food additives, ingredients in nutritional supplements, and cosmetics.

  20. Diagnostic Utility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman Disease Subtypes and Reactive Lymphadenopathies.

    PubMed

    Post, Ginell R; Bell, Robert C; Rjoop, Anwar; Lobo, Rodolfo Henrich; Yuan, Youzhong; Post, Steven R

    2016-09-01

    The objective of the study was to evaluate the expression pattern of interleukin-6 (IL-6) to determine its utility in differentiating Castleman Disease subtypes and reactive lymphadenopathies. Paraffin-embedded tissue blocks from 20 cases referred for assessment of Castleman Disease (CD) and 4 cases of reactive hyperplasia were selected for immunohistochemical staining with an IL-6 antibody. Six pathologists evaluated the hematoxylin and eosin stained tissue sections and IL-6 expression pattern. Of 20 CD referral cases, the pathologic diagnosis was CD in 14 cases and included 6 hyaline-vascular (HV-CD), 6 plasma cell (PC-CD) and 2 "mixed type"-CD cases. The remaining 6 referral cases showed morphologic features consistent with reactive lymphadenopathy. Patients with non-CD, reactive lymphadenopathies had clinical and/or laboratory features of systemic lupus erythematosus, Hashimoto's disease, viral infection or chronic cellulitis. The pattern of IL-6 expression differed between CD subtypes and non-CD cases. In PC-CD, IL-6 expression was detected in plasma cells and vascular endothelial cells; whereas IL-6 immunoreactivity was detected primarily in vascular endothelial cells in HV-CD. Interfollicular plasma cells were prominent in PC-CD and reactive lymphadenopathies; however, IL-6 expression was significantly increased in PC-CD compared to reactive lymph nodes. Together with morphologic features, the expression pattern of IL-6 detected by immunohistochemistry is helpful to distinguish CD subtypes and reactive mimics. PMID:27650613

  1. A haemophilia disease management programme targeting cost and utilization of specialty pharmaceuticals.

    PubMed

    Duncan, N; Roberson, C; Lail, A; Donfield, S; Shapiro, A

    2014-07-01

    The high cost of clotting factor concentrate (CFC) used to treat haemophilia and von Willebrand disease (VWD) attracts health plans' attention for cost management strategies such as disease management programmes (DMPs). In 2004, Indiana's high risk insurance health plan, the Indiana Comprehensive Health Insurance Association, in partnership with the Indiana Hemophilia and Thrombosis Center developed and implemented a DMP for beneficiaries with bleeding disorders. This report evaluates the effectiveness of the DMP 5 years post implementation, with specific emphasis on the cost of CFC and other medical expenditures by severity of disease. A pre/post analysis was used. The main evaluation measures were total cost, total outpatient CFC IU dispensed and adjusted total outpatient CFC cost. Summary statistics and mean and median plots were calculated. Overall, 1000 non-parametric bootstrap replicates were created and percentile confidence limits for 95% confidence intervals (CI) are reported. Mean emergency department (ED) visits and mean and median duration of hospitalizations are also reported. The DMP was associated with a significant decrease in mean annualized total cost including decreased CFC utilization and cost in most years in the overall group, and specifically in patients with severe haemophilia. Patients with mild and moderate haemophilia contributed little to overall programme expenditures. This specialty health care provider-administered DMP exemplifies the success of targeted interventions developed and implemented through a health care facility expert in the disease state to curb the cost of specialty pharmaceuticals in conditions when their expenditures represent a significant portion of total annual costs of care.

  2. The Clinical Utility of Health Related Quality of Life Screening in a Pediatric Inflammatory Bowel Disease Clinic

    PubMed Central

    Ryan, Jamie L.; Mellon, Michael W.; Junger, Katherine W. F.; Hente, Elizabeth A.; Denson, Lee A.; Saeed, Shehzad A.; Hommel, Kevin A.

    2013-01-01

    Background Adjusting to symptom flares, treatment regimens, and side effects places youth with inflammatory bowel disease (IBD) at increased risk for emotional and behavioral problems and adverse disease outcomes. Implementation of psychosocial screening into clinical practice remains a challenge. This study examines the clinical utility of health-related quality of life (HRQOL) screening in predicting disease outcome and healthcare utilization. Methods One-hundred twelve youth 7-18 years diagnosed with IBD and their parents. Youth completed standardized measures of HRQOL and depression. Parents completed a proxy-report of HRQOL. Pediatric gastroenterologists provided the Physician Global Assessment. Families were recruited from a pediatric gastroenterology clinic. Retrospective chart reviews examined disease outcome and healthcare utilization 12-months following baseline measurement. Results Linear regressions, controlling for demographic and disease parameters, revealed that baseline measurement of youth and parent proxy-reported HRQOL predicted the number of IBD-related hospital admissions, gastroenterology clinic visits, Emergency Department visits, psychology clinic visits, telephone contacts, and pain management referrals over the next 12 months. Disease outcome was not significant. Conclusions Lower HRQOL was predictive of increased healthcare utilization among youth with IBD. Regular HRQOL screening may be the impetus to providing better case management and allocating resources based on ongoing care needs and costs. Proactive interventions focused on patients with poor HRQOL may be an efficient approach to saving on healthcare costs and resource utilization. PMID:24051932

  3. Resource Utilization for Noncardiac Admissions in Pediatric Patients With Single Ventricle Disease.

    PubMed

    Thomas, Ian D; Seckeler, Michael D

    2016-05-15

    Patients with single ventricle (SV) congenital heart disease (CHD) incur high hospital costs during staged surgical palliation. Health care resource utilization for noncardiac admissions in patients with SV has not been reported. This study sought to compare costs and outcomes for common noncardiac hospital admissions between patients with SV and patients without CHD. Hospital discharge data from the University Health System Consortium from January 2011 to December 2013 was queried for patients aged ≤18 years with International Classification of Diseases, Ninth Revision (ICD-9) codes for SV lesions: hypoplastic left heart syndrome (746.7), tricuspid atresia (746.1), or common ventricle (745.3). Primary diagnosis, direct cost, length of stay (LOS), intensive care unit admission rate and mortality data were obtained. The 10 most common noncardiac admission diagnoses were compared between patients with SV and patients without CHD using t test and Fisher's exact test. Total direct cost, LOS, and intensive care unit admission rate were higher for patients with SV for all diagnoses with the exception of LOS for dehydration, which was not different between groups. Hospital mortality was significantly higher for patients with SV admitted for acute kidney injury, esophageal reflux, failure to thrive, respiratory syncytial virus bronchiolitis and pneumonia. In conclusion, our study demonstrates that patients with SV CHD admitted with noncardiac diagnoses have higher health care resource utilization compared to those without CHD. As long-term survival increases, it can be expected that this patient group will use a disproportionate amount of medical dollars. Further characterization of costs will be important so steps can be taken to reduce or prevent hospitalization in these patients. PMID:27018934

  4. Health care utilization, prognosis and outcomes of vestibular disease in primary care settings: systematic review.

    PubMed

    Grill, Eva; Penger, Mathias; Kentala, Erna

    2016-04-01

    Vertigo and dizziness are frequent complaints in primary care that lead to extensive health care utilization. The objective of this systematic review was to examine health care of patients with vertigo and dizziness in primary care settings. Specifically, we wanted to characterize health care utilization, therapeutic and referral behaviour and to examine the outcomes associated with this. A search of the MEDLINE and EMBASE databases was carried out in May 2015 using the search terms 'vertigo' or 'dizziness' or 'vestibular and primary care' to identify suitable studies. We included all studies that were published in the last 10 years in English with the primary diagnoses of vertigo, dizziness and/or vestibular disease. We excluded drug evaluation studies and reports of adverse drug reactions. Data were extracted and appraised by two independent reviewers; 16 studies with a total of 2828 patients were included. Mean age of patients ranged from 45 to 79 with five studies in older adults aged 65 or older. There were considerable variations in diagnostic criteria, referral and therapy while the included studies failed to show significant improvement of patient-reported outcomes. Studies are needed to investigate current practice of care across countries and health systems in a systematic way and to test primary care-based education and training interventions that improve outcomes. PMID:27083883

  5. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases

    PubMed Central

    Sailer, Anna; Scholz, Sonja W.; Gibbs, J. Raphael; Tucci, Arianna; Johnson, Janel O.; Wood, Nicholas W.; Plagnol, Vincent; Hummerich, Holger; Ding, Jinhui; Hernandez, Dena; Hardy, John; Federoff, Howard J.; Traynor, Bryan J.; Singleton, Andrew B.

    2012-01-01

    Objective: Genetic heterogeneity is common in many neurologic disorders. This is particularly true for the hereditary ataxias where at least 36 disease genes or loci have been described for spinocerebellar ataxia and over 100 genes for neurologic disorders that present primarily with ataxia. Traditional genetic testing of a large number of candidate genes delays diagnosis and is expensive. In contrast, recently developed genomic techniques, such as exome sequencing that targets only the coding portion of the genome, offer an alternative strategy to rapidly sequence all genes in a comprehensive manner. Here we describe the use of exome sequencing to investigate a large, 5-generational British kindred with an autosomal dominant, progressive cerebellar ataxia in which conventional genetic testing had not revealed a causal etiology. Methods: Twenty family members were seen and examined; 2 affected individuals were clinically investigated in detail without a genetic or acquired cause being identified. Exome sequencing was performed in one patient where coverage was comprehensive across the known ataxia genes, excluding the known repeat loci which should be examined using conventional analysis. Results: A novel p.Arg26Gly change in the PRKCG gene, mutated in SCA14, was identified. This variant was confirmed using Sanger sequencing and showed segregation with disease in the entire family. Conclusions: This work demonstrates the utility of exome sequencing to rapidly screen heterogeneous genetic disorders such as the ataxias. Exome sequencing is more comprehensive, faster, and significantly cheaper than conventional Sanger sequencing, and thus represents a superior diagnostic screening tool in clinical practice. PMID:22675081

  6. A global network for the control of snail-borne disease using satellite surveillance and geographic information systems.

    PubMed

    Malone, J B; Bergquist, N R; Huh, O K; Bavia, M E; Bernardi, M; El Bahy, M M; Fuentes, M V; Kristensen, T K; McCarroll, J C; Yilma, J M; Zhou, X N

    2001-04-27

    At a team residency sponsored by the Rockefeller Foundation in Bellagio, Italy, 10-14 April 2000 an organizational plan was conceived to create a global network of collaborating health workers and earth scientists dedicated to the development of computer-based models that can be used for improved control programs for schistosomiasis and other snail-borne diseases of medical and veterinary importance. The models will be assembled using GIS methods, global climate model data, sensor data from earth observing satellites, disease prevalence data, the distribution and abundance of snail hosts, and digital maps of key environmental factors that affect development and propagation of snail-borne disease agents. A work plan was developed for research collaboration and data sharing, recruitment of new contributing researchers, and means of access of other medical scientists and national control program managers to GIS models that may be used for more effective control of snail-borne disease. Agreement was reached on the use of compatible GIS formats, software, methods and data resources, including the definition of a 'minimum medical database' to enable seamless incorporation of results from each regional GIS project into a global model. The collaboration plan calls for linking a 'central resource group' at the World Health Organization, the Food and Agriculture Organization, Louisiana State University and the Danish Bilharziasis Laboratory with regional GIS networks to be initiated in Eastern Africa, Southern Africa, West Africa, Latin America and Southern Asia. An Internet site, www.gnosisGIS.org, (GIS Network On Snail-borne Infections with special reference to Schistosomiasis), has been initiated to allow interaction of team members as a 'virtual research group'. When completed, the site will point users to a toolbox of common resources resident on computers at member organizations, provide assistance on routine use of GIS health maps in selected national disease control

  7. A global network for the control of snail-borne disease using satellite surveillance and geographic information systems.

    PubMed

    Malone, J B; Bergquist, N R; Huh, O K; Bavia, M E; Bernardi, M; El Bahy, M M; Fuentes, M V; Kristensen, T K; McCarroll, J C; Yilma, J M; Zhou, X N

    2001-04-27

    At a team residency sponsored by the Rockefeller Foundation in Bellagio, Italy, 10-14 April 2000 an organizational plan was conceived to create a global network of collaborating health workers and earth scientists dedicated to the development of computer-based models that can be used for improved control programs for schistosomiasis and other snail-borne diseases of medical and veterinary importance. The models will be assembled using GIS methods, global climate model data, sensor data from earth observing satellites, disease prevalence data, the distribution and abundance of snail hosts, and digital maps of key environmental factors that affect development and propagation of snail-borne disease agents. A work plan was developed for research collaboration and data sharing, recruitment of new contributing researchers, and means of access of other medical scientists and national control program managers to GIS models that may be used for more effective control of snail-borne disease. Agreement was reached on the use of compatible GIS formats, software, methods and data resources, including the definition of a 'minimum medical database' to enable seamless incorporation of results from each regional GIS project into a global model. The collaboration plan calls for linking a 'central resource group' at the World Health Organization, the Food and Agriculture Organization, Louisiana State University and the Danish Bilharziasis Laboratory with regional GIS networks to be initiated in Eastern Africa, Southern Africa, West Africa, Latin America and Southern Asia. An Internet site, www.gnosisGIS.org, (GIS Network On Snail-borne Infections with special reference to Schistosomiasis), has been initiated to allow interaction of team members as a 'virtual research group'. When completed, the site will point users to a toolbox of common resources resident on computers at member organizations, provide assistance on routine use of GIS health maps in selected national disease control

  8. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance.

    PubMed

    Liu, Lifeng; Dang, Phat M; Chen, Charles Y

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations.

  9. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance

    PubMed Central

    Liu, Lifeng; Dang, Phat M.; Chen, Charles Y.

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations. PMID:26617627

  10. Hodgkin disease and non-Hodgkin lymphomas in children: utilization of radiological modalities

    SciTech Connect

    Cohen, M.D.; Siddiqui, A.; Weetman, R.; Provisor, A.; Coates, T.

    1986-02-01

    If costs of medical care are to be reduced, the choice of which imaging modality to use must be made as carefully as possible. This study was done to show how radiological modalities were used to evaluate patients with Hodgkin disease and non-Hodgkin lymphoma. We kept a record of every radiological study performed on 66 children with both diseases seen in the past 6 1/3 years. The results of these studies were analyzed to see which areas of the body were studied, which imaging modality was used, how frequently the studies were repeated, and how frequently the studies gave abnormal results. Our findings disclosed that radiological studies have been appropriately performed in anatomic regions of the body in which disease is present. New imaging modalities have been introduced, and the use of some of the older modalities has been decreased. With some modalities, such as skeletal survey, liver/spleen scan, whole-lung tomography, contrast studies of the bowel, and excretory urography, utilization is higher than it ought to be in view of the fact that the yield of positive results is low and the information is obtainable in many cases from other more sensitive procedures. These studies should not be performed as a routine on initial evaluation or follow-up of all patients with Hodgkin or non-Hodgkin lymphomas. On initial presentation all patients should undergo chest radiography and CT scanning of both chest and abdomen. A problem area is that the timing of follow-up studies has been somewhat erratic, with some inappropriate studies particularly 3 or 4 years after diagnosis. Too many imaging procedures have probably been done in follow-up of our patients.

  11. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

    PubMed Central

    Khare, Shilpi; Roach, Steven L.; Barnes, S. Whitney; Hoepfner, Dominic; Walker, John R.; Chatterjee, Arnab K.; Neitz, R. Jeffrey; Arkin, Michelle R.; McNamara, Case W.; Ballard, Jaime; Lai, Yin; Fu, Yue; Molteni, Valentina; Yeh, Vince; McKerrow, James H.; Glynne, Richard J.; Supek, Frantisek

    2015-01-01

    Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be used as starting points for drug discovery programs that target such mechanisms. A major challenge of the approach is the identification of the cellular targets. Here we report GNF7686, a small molecule inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease, and identification of cytochrome b as its target. Following discovery of GNF7686 in a parasite growth inhibition high throughput screen, we were able to evolve a GNF7686-resistant culture of T. cruzi epimastigotes. Clones from this culture bore a mutation coding for a substitution of leucine by phenylalanine at amino acid position 197 in cytochrome b. Cytochrome b is a component of complex III (cytochrome bc1) in the mitochondrial electron transport chain and catalyzes the transfer of electrons from ubiquinol to cytochrome c by a mechanism that utilizes two distinct catalytic sites, QN and QP. The L197F mutation is located in the QN site and confers resistance to GNF7686 in both parasite cell growth and biochemical cytochrome b assays. Additionally, the mutant cytochrome b confers resistance to antimycin A, another QN site inhibitor, but not to strobilurin or myxothiazol, which target the QP site. GNF7686 represents a promising starting point for Chagas disease drug discovery as it potently inhibits growth of intracellular T. cruzi amastigotes with a half maximal effective concentration (EC50) of 0.15 µM, and is highly specific for T. cruzi cytochrome b. No effect on the mammalian respiratory chain or mammalian cell proliferation was observed with up to 25 µM of GNF7686. Our approach, which combines T. cruzi chemical genetics with biochemical target validation, can be broadly applied to the discovery of additional novel drug targets and drug leads for Chagas disease. PMID:26186534

  12. Utility of meibography in the evaluation of meibomian glands morphology in normal and diseased eyelids☆

    PubMed Central

    Alsuhaibani, Adel H.; Carter, Keith D.; Abràmoff, Michael D.; Nerad, Jeffrey A.

    2010-01-01

    Purpose To study the utility of meibography for the morphology of meibomian glands in normal eyelids and in various eyelid diseases. Design A cross-sectional study. Methods A newly designed transilluminator, fitting both the upper along with lower eyelids, and an infrared camera were used to obtain video clips of the meibomian glands for 60 asymptomatic subjects with normal eyelid margin. Parameters studied included, ocular surface, Schirmer test, and tear breakup time (TBUT). The meibomian glands of patients with meibomian glands’ abnormality secondary to infectious, inflammatory, malignant, congenital, or post-radiation therapy disease related etiologies were compared with normal patients. Still pictures were extracted from the video clips to evaluate the meibomian glands for gland dropout and gross morphological changes. Results In normal subjects, meibomian glands appeared to be thinner and longer in the upper eye lids than in the lower eye lids. Gland dropout occured with increased age, more in the lower eye lid and in females. Excessive gland drop out (> 75%) was seen in patients with history of trachoma, Stevens Johnson syndrome, severe blepharitis, and post-radiation for orbital tumors. Variable gland drop out was noticed in patients with floppy eyelid syndrome, and blepharitis. In patients with congenital distichiasis, partial or complete gland drop out at the part of the eyelid margins affected by distichiasis was noticed. Conclusions The newly designed transilluminator permitted the examination of both upper and lower eye lid meibomian glands with minimal discomfort. Evaluating the anatomical changes involving meibomian glands with meibography may help increase our understanding of the meibomian gland-related diseases, monitor the effects of treatment, and provide helpful information for patient education. PMID:23960903

  13. Simulation of the water regime for a vast agricultural region territory utilizing measurements from polar-orbital and geostationary meteorological satellites

    NASA Astrophysics Data System (ADS)

    Muzylev, Eugene; Uspensky, Alexander; Startseva, Zoya; Volkova, Elena; Kukharsky, Alexander; Uspensky, Sergey

    2013-04-01

    The model of land surface-atmosphere interaction has been developed to calculate the water and heat balance components for vast vegetation covered areas during the growing season. The model is adjusted to utilize estimates of the land surface and meteorological characteristics derived from satellite-based measurements of radiometers AVHRR/NOAA, MODIS/EOS Terra, Aqua, and SEVIRI/Meteosat-9. The studies have been conducted for the territory of the European Russia Central Black Earth Region (CCR) with area of 227,300 km2 comprising seven regions of the Russian Federation for years 2009-2012 vegetation seasons. The technologies of AVHRR and MODIS data thematic processing have been refined and adapted to the study region providing the retrieval of land surface temperature Tls and emissivity E, land-air temperature (temperature at vegetation cover level) Ta, normalized difference vegetation index NDVI, vegetation cover fraction B, as well as the leaf area index LAI. The updated linear regression estimators for Tls, Ta and LAI have been built using more representative training samples compiled for the above vegetation seasons. The updated software package has been applied for AVHRR data processing to generate named remote sensing products for various dates of the mentioned vegetation periods. On the base of special technology and Internet resources the remote sounding products (Tls, E, NDVI, LAI), derived from MODIS data and covering the CCR, have been downloaded from LP DAAC web-site for the same vegetation seasons. The new method and technology have been developed and adopted for the retrieval of Tls and E from SEVIRI data. The retrievals cover the region of interest and are produced at daylight and nighttime. Method provides the derivation of Tls and E from SEVIRI measurements carried out at three successive times (for example, at 11.00, 12.00, 13.00 UTC), classified as 100% cloud-free for the study region without accurate a priori knowledge of E. The validation of

  14. Linking Satellite Remote Sensing Based Environmental Predictors to Disease: AN Application to the Spatiotemporal Modelling of Schistosomiasis in Ghana

    NASA Astrophysics Data System (ADS)

    Wrable, M.; Liss, A.; Kulinkina, A.; Koch, M.; Biritwum, N. K.; Ofosu, A.; Kosinski, K. C.; Gute, D. M.; Naumova, E. N.

    2016-06-01

    90% of the worldwide schistosomiasis burden falls on sub-Saharan Africa. Control efforts are often based on infrequent, small-scale health surveys, which are expensive and logistically difficult to conduct. Use of satellite imagery to predictively model infectious disease transmission has great potential for public health applications. Transmission of schistosomiasis requires specific environmental conditions to sustain freshwater snails, however has unknown seasonality, and is difficult to study due to a long lag between infection and clinical symptoms. To overcome this, we employed a comprehensive 8-year time-series built from remote sensing feeds. The purely environmental predictor variables: accumulated precipitation, land surface temperature, vegetative growth indices, and climate zones created from a novel climate regionalization technique, were regressed against 8 years of national surveillance data in Ghana. All data were aggregated temporally into monthly observations, and spatially at the level of administrative districts. The result of an initial mixed effects model had 41% explained variance overall. Stratification by climate zone brought the R2 as high as 50% for major zones and as high as 59% for minor zones. This can lead to a predictive risk model used to develop a decision support framework to design treatment schemes and direct scarce resources to areas with the highest risk of infection. This framework can be applied to diseases sensitive to climate or to locations where remote sensing would be better suited than health surveys.

  15. Inert gas washout: theoretical background and clinical utility in respiratory disease.

    PubMed

    Robinson, Paul D; Goldman, Michael D; Gustafsson, Per M

    2009-01-01

    Inert gas washout was first described more than 60 years ago and 2 principal tests have been developed from it: the single breath and multiple breath washout (MBW) techniques. The invention of fast responding gas analysers almost 60 years ago and small computers 30 years later have facilitated breath-by-breath analysis and the development of sophisticated analysis techniques. It is now possible to detect not only the degree of pulmonary ventilation inhomogeneity, but also to gain important insight into the location of the underlying disease process. While single breath washout requires a full vital capacity effort, tidal breathing during the multiple breath test requires minimal co-operation and co-ordination, and is feasible in subjects of all ages. Available MBW normative data from parameters, such as the lung clearance index, appears to vary minimally with age, making MBW particularly useful to follow children longitudinally. Multiple breath inert gas washout has demonstrated improved sensitivity, in comparison to spirometry, in the early detection of a number of important disease processes, including cystic fibrosis. Despite this, these important techniques remain under-utilised in the clinical setting and there is a lack of commercially available devices currently available. The recent resurgence of research in this area has produced a large number of important studies and a pronounced international interest has developed in these techniques. This review article will provide an overview of the theoretical background of inert gas washout and analysis indices, review important physiological and clinical insights gained from research to date (as well as from our own experience) to illustrate its utility, and outline the challenges that lie ahead in incorporating these techniques into the mainstream clinical setting. PMID:19521061

  16. FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease

    PubMed Central

    Rosenfeld, Greg; Greenup, Astrid-Jane; Round, Andrew; Takach, Oliver; Halparin, Lawrence; Saadeddin, Abid; Ho, Jin Kee; Lee, Terry; Enns, Robert; Bressler, Brian

    2016-01-01

    AIM To evaluate the perspective of gastroenterologists regarding the impact of fecal calprotectin (FC) on the management of patients with inflammatory bowel disease (IBD). METHODS Patients with known IBD or symptoms suggestive of IBD for whom the physician identified that FC would be clinically useful were recruited. Physicians completed an online “pre survey” outlining their rationale for the test. After receipt of the test results, the physicians completed an online “post survey” to portray their perceived impact of the test result on patient management. Clinical outcomes for a subset of patients with follow-up data available beyond the completion of the “post survey” were collected and analyzed. RESULTS Of 373 test kits distributed, 290 were returned, resulting in 279 fully completed surveys. One hundred and ninety patients were known to have IBD; 147 (77%) with Crohn’s Disease, 43 (21%) Ulcerative Colitis and 5 (2%) IBD unclassified. Indications for FC testing included: 90 (32.2%) to differentiate a new diagnosis of IBD from Irritable Bowel Syndrome (IBS), 85 (30.5%) to distinguish symptoms of IBS from IBD in those known to have IBD and 104 (37.2%) as an objective measure of inflammation. FC levels resulted in a change in management 51.3% (143/279) of the time which included a significant reduction in the number of colonoscopies (118) performed (P < 0.001). Overall, 97.5% (272/279) of the time, the physicians found the test sufficiently useful that they would order it again in similar situations. Follow-up data was available for 172 patients with further support for the clinical utility of FC provided. CONCLUSION The FC test effected a change in management 51.3% of the time and receipt of the result was associated with a reduction in the number of colonoscopies performed.

  17. FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease

    PubMed Central

    Rosenfeld, Greg; Greenup, Astrid-Jane; Round, Andrew; Takach, Oliver; Halparin, Lawrence; Saadeddin, Abid; Ho, Jin Kee; Lee, Terry; Enns, Robert; Bressler, Brian

    2016-01-01

    AIM To evaluate the perspective of gastroenterologists regarding the impact of fecal calprotectin (FC) on the management of patients with inflammatory bowel disease (IBD). METHODS Patients with known IBD or symptoms suggestive of IBD for whom the physician identified that FC would be clinically useful were recruited. Physicians completed an online “pre survey” outlining their rationale for the test. After receipt of the test results, the physicians completed an online “post survey” to portray their perceived impact of the test result on patient management. Clinical outcomes for a subset of patients with follow-up data available beyond the completion of the “post survey” were collected and analyzed. RESULTS Of 373 test kits distributed, 290 were returned, resulting in 279 fully completed surveys. One hundred and ninety patients were known to have IBD; 147 (77%) with Crohn’s Disease, 43 (21%) Ulcerative Colitis and 5 (2%) IBD unclassified. Indications for FC testing included: 90 (32.2%) to differentiate a new diagnosis of IBD from Irritable Bowel Syndrome (IBS), 85 (30.5%) to distinguish symptoms of IBS from IBD in those known to have IBD and 104 (37.2%) as an objective measure of inflammation. FC levels resulted in a change in management 51.3% (143/279) of the time which included a significant reduction in the number of colonoscopies (118) performed (P < 0.001). Overall, 97.5% (272/279) of the time, the physicians found the test sufficiently useful that they would order it again in similar situations. Follow-up data was available for 172 patients with further support for the clinical utility of FC provided. CONCLUSION The FC test effected a change in management 51.3% of the time and receipt of the result was associated with a reduction in the number of colonoscopies performed. PMID:27688663

  18. Limited Diagnostic Utility of Plasma Adrenocorticotropic Hormone for Differentiation between Adrenal Cushing Syndrome and Cushing Disease

    PubMed Central

    Hong, A Ram; Kim, Jung Hee; Hong, Eun Shil; Kim, I Kyeong; Park, Kyeong Seon; Ahn, Chang Ho; Kim, Sang Wan; Shin, Chan Soo

    2015-01-01

    Background Measurement of the plasma adrenocorticotropic hormone (ACTH) level has been recommended as the first diagnostic test for differentiating between ACTH-independent Cushing syndrome (CS) and ACTH-dependent CS. When plasma ACTH values are inconclusive, a differential diagnosis of CS can be made based upon measurement of the serum dehydroepiandrosterone sulfate (DHEA-S) level and results of the high-dose dexamethasone suppression test (HDST). The aim of this study was to assess the utility of plasma ACTH to differentiate adrenal CS from Cushing' disease (CD) and compare it with that of the HDST results and serum DHEA-S level. Methods We performed a retrospective, multicenter study from January 2000 to May 2012 involving 92 patients with endogenous CS. The levels of plasma ACTH, serum cortisol, 24-hour urine free cortisol (UFC) after the HDST, and serum DHEA-S were measured. Results Fifty-seven patients had adrenal CS and 35 patients had CD. The area under the curve of plasma ACTH, serum DHEA-S, percentage suppression of serum cortisol, and UFC after HDST were 0.954, 0.841, 0.950, and 0.997, respectively (all P<0.001). The cut-off values for plasma ACTH, percentage suppression of serum cortisol, and UFC after HDST were 5.3 pmol/L, 33.3%, and 61.6%, respectively. The sensitivity and specificity of plasma ACTH measurement were 84.2% and 94.3%, those of serum cortisol were 95.8% and 90.6%, and those of UFC after the HDST were 97.9% and 96.7%, respectively. Conclusion Significant overlap in plasma ACTH levels was seen between patients with adrenal CS and those with CD. The HDST may be useful in differentiating between these forms of the disease, especially when the plasma ACTH level alone is not conclusive. PMID:26248856

  19. The AmpliChip CYP450 test: principles, challenges, and future clinical utility in digestive disease.

    PubMed

    Juran, Brian D; Egan, Laurence J; Lazaridis, Konstantinos N

    2006-07-01

    Understanding genetically encoded inherited differences in drug metabolism and targets (ie, receptors, transporters) offers the promise of minimizing adverse drug reactions and improving therapies. Among the enzymes involved in drug metabolism, the cytochromes P450 (CYP450) hold a central position. In fact, CYP450 are involved in the biotransformation of most drugs used in clinical practice. Recent advances in the development of DNA-based diagnostics, coupled with a better understanding of genetic polymorphisms in influencing pharmacologic responses, have provided the foundation for novel in vitro tests that may predict side effects and/or therapeutic responses. The AmpliChip CYP450 test was developed as a clinical test to evaluate an individual's metabolic capacity for certain drugs by identifying polymorphisms of 2 CYP450 enzymes (ie, CYP2D6 and CYP2D19). Even though the AmpliChip CYP450 has been approved by the US Food and Drug Administration, its practical clinical utility has not yet been determined, and there is a paucity of data related to gastrointestinal and liver diseases. An understanding of the principles and opportunities provided by this new category of diagnostic test is key before planning the necessary studies to evaluate the usefulness of AmpliChip CYP450 in gastroenterologic clinical practice.

  20. Clinical utility of platinum chromium bare-metal stents in coronary heart disease

    PubMed Central

    Jorge, Claudia; Dubois, Christophe

    2015-01-01

    Coronary stents represent a key development for the treatment of obstructive coronary artery disease since the introduction of percutaneous coronary intervention. While drug-eluting stents gained wide acceptance in contemporary percutaneous coronary intervention practice, further developments in bare-metal stents remain crucial for patients who are not candidates for drug-eluting stents, or to improve metallic platforms for drug elution. Initially, stent platforms used biologically inert stainless steel, restricting stent performance due to limitations in flexibility and strut thickness. Later, cobalt chromium stent alloys outperformed steel as the material of choice for stents, allowing latest generation stents to be designed with significantly thinner struts, while maintaining corrosion resistance and radial strength. Most recently, the introduction of the platinum chromium alloy refined stent architecture with thin struts, high radial strength, conformability, and improved radiopacity. This review will provide an overview of the novel platinum chromium bare-metal stent platforms available for coronary intervention. Mechanical properties, clinical utility, and device limitations will be summarized and put into perspective. PMID:26345228

  1. Clinical utility of platinum chromium bare-metal stents in coronary heart disease.

    PubMed

    Jorge, Claudia; Dubois, Christophe

    2015-01-01

    Coronary stents represent a key development for the treatment of obstructive coronary artery disease since the introduction of percutaneous coronary intervention. While drug-eluting stents gained wide acceptance in contemporary percutaneous coronary intervention practice, further developments in bare-metal stents remain crucial for patients who are not candidates for drug-eluting stents, or to improve metallic platforms for drug elution. Initially, stent platforms used biologically inert stainless steel, restricting stent performance due to limitations in flexibility and strut thickness. Later, cobalt chromium stent alloys outperformed steel as the material of choice for stents, allowing latest generation stents to be designed with significantly thinner struts, while maintaining corrosion resistance and radial strength. Most recently, the introduction of the platinum chromium alloy refined stent architecture with thin struts, high radial strength, conformability, and improved radiopacity. This review will provide an overview of the novel platinum chromium bare-metal stent platforms available for coronary intervention. Mechanical properties, clinical utility, and device limitations will be summarized and put into perspective. PMID:26345228

  2. Landscape characterization of peridomestic risk for Lyme disease using satellite imagery

    NASA Technical Reports Server (NTRS)

    Dister, S. W.; Fish, D.; Bros, S. M.; Frank, D. H.; Wood, B. L.

    1997-01-01

    Remotely sensed characterizations of landscape composition were evaluated for Lyme disease exposure risk on 337 residential properties in two communities of suburban Westchester County, New York. Properties were categorized as no, low, or high risk based on seasonally adjusted densities of Ixodes scapularis nymphs, determined by drag sampling during June and July 1990. Spectral indices based on Landsat Thematic Mapper data provided relative measures of vegetation structure and moisture (wetness), as well as vegetation abundance (greenness). A geographic information system (GIS) was used to spatially quantify and relate the remotely sensed landscape variables to risk category. A comparison of the two communities showed that Chappaqua, which had more high-risk properties (P < 0.001), was significantly greener and wetter than Armonk (P < 0.001). Furthermore, within Chappaqua, high-risk properties were significantly greener and wetter than lower-risk properties in this community (P < 0.01). The high-risk properties appeared to contain a greater proportion of broadleaf trees, while lower-risk properties were interpreted as having a greater proportion of nonvegetative cover and/or open lawn. The ability to distinguish these fine scale differences among communities and individual properties illustrates the efficiency of a remote sensing/GIS-based approach for identifying peridomestic risk of Lyme disease over large geographic areas.

  3. Computational model of precision grip in Parkinson's disease: a utility based approach.

    PubMed

    Gupta, Ankur; Balasubramani, Pragathi P; Chakravarthy, V Srinivasa

    2013-01-01

    We propose a computational model of Precision Grip (PG) performance in normal subjects and Parkinson's Disease (PD) patients. Prior studies on grip force generation in PD patients show an increase in grip force during ON medication and an increase in the variability of the grip force during OFF medication (Ingvarsson et al., 1997; Fellows et al., 1998). Changes in grip force generation in dopamine-deficient PD conditions strongly suggest contribution of the Basal Ganglia, a deep brain system having a crucial role in translating dopamine signals to decision making. The present approach is to treat the problem of modeling grip force generation as a problem of action selection, which is one of the key functions of the Basal Ganglia. The model consists of two components: (1) the sensory-motor loop component, and (2) the Basal Ganglia component. The sensory-motor loop component converts a reference position and a reference grip force, into lift force and grip force profiles, respectively. These two forces cooperate in grip-lifting a load. The sensory-motor loop component also includes a plant model that represents the interaction between two fingers involved in PG, and the object to be lifted. The Basal Ganglia component is modeled using Reinforcement Learning with the significant difference that the action selection is performed using utility distribution instead of using purely Value-based distribution, thereby incorporating risk-based decision making. The proposed model is able to account for the PG results from normal and PD patients accurately (Ingvarsson et al., 1997; Fellows et al., 1998). To our knowledge the model is the first model of PG in PD conditions. PMID:24348373

  4. Prognostic Utility of Secretory Phospholipase A2 in Patients with Stable Coronary Artery Disease

    PubMed Central

    O’Donoghue, Michelle; Mallat, Ziad; Morrow, David A; Benessiano, Joelle; Sloan, Sarah; Omland, Torbjørn; Solomon, Scott D.; Braunwald, Eugene; Tedgui, Alain; Sabatine, Marc S

    2011-01-01

    Background Secretory phospholipase A2 (sPLA2) may contribute to atherogenesis. To date, few prospective studies have examined the utility of sPLA2 for risk stratification in coronary artery disease (CAD). Methods Plasma sPLA2 activity was measured at baseline in 3708 subjects in the PEACE randomized trial of trandolapril versus placebo in stable CAD. Median follow-up was 4.8 years. Cox regression was used to adjust for demographics, clinical risk factors, apolipoprotein B, apolipoprotein A1, and medications. Results After multivariable adjustment, sPLA2 was associated with an increased risk of cardiovascular death, myocardial infarction or stroke (adjusted hazard ratio quartile 4:quartile 1 1.55, 95% CI 1.13–2.14) and cardiovascular death or heart failure (adjusted hazard ratio quartile 4:quartile 1 1.91, 95% CI 1.20–3.03). In further multivariable assessment, increased activities of sPLA2 were associated with the risk of cardiovascular death, myocardial infarction or stroke (adjusted hazard ratio 1.47, 95% CI 1.06–2.04) independent of lipoprotein-associated phospholipase A2 mass and C-reactive protein, and modestly improved the area under the curve (AUC) beyond established clinical risk factors (AUC 0.668 to 0.675, P=0.01). sPLA2, NT-pro B-type natriuretic peptide and high-sensitivity cardiac troponin T were all independently associated with cardiovascular death or heart failure and each improved risk discrimination (P=0.02, P<0.001, P<0.001, respectively). Conclusion sPLA2 activity provides independent prognostic information beyond established risk markers in patients with stable CAD. These data are encouraging for studies designed to evaluate the role of sPLA2 as a therapeutic target. PMID:21784767

  5. Synergistic Utilization of Microwave Satellite Data and GRACE-Total Water Storage Anomaly for Improving Available Water Capacity Prediction in Lower Mekong Basin

    NASA Astrophysics Data System (ADS)

    Gupta, M.; Bolten, J. D.; Lakshmi, V.

    2015-12-01

    The Mekong River is the longest river in Southeast Asia and the world's eighth largest in discharge with draining an area of 795,000 km² from the eastern watershed of the Tibetan Plateau to the Mekong Delta including three provinces of China, Myanmar, Lao PDR, Thailand, Cambodia and Viet Nam. This makes the life of people highly vulnerable to availability of the water resources as soil moisture is one of the major fundamental variables in global hydrological cycles. The day-to-day variability in soil moisture on field to global scales is an important quantity for early warning systems for events like flooding and drought. In addition to the extreme situations the accurate soil moisture retrieval are important for agricultural irrigation scheduling and water resource management. The present study proposes a method to determine the effective soil hydraulic parameters directly from information available for the soil moisture state from the recently launched SMAP (L-band) microwave remote sensing observations. Since the optimized parameters are based on the near surface soil moisture information, further constraints are applied during the numerical simulation through the assimilation of GRACE Total Water Storage (TWS) within the physically based land surface model. This work addresses the improvement of available water capacity as the soil hydraulic parameters are optimized through the utilization of satellite-retrieved near surface soil moisture. The initial ranges of soil hydraulic parameters are taken in correspondence with the values available from the literature based on FAO. The optimization process is divided into two steps: the state variable are optimized and the optimal parameter values are then transferred for retrieving soil moisture and streamflow. A homogeneous soil system is considered as the soil moisture from sensors such as AMSR-E/SMAP can only be retrieved for the top few centimeters of soil. To evaluate the performance of the system in helping

  6. Utilization of ERTS data to detect plant diseases and nutrient deficiencies, soil types and moisture levels

    NASA Technical Reports Server (NTRS)

    Parks, W. L. (Principal Investigator); Sewell, J. I.; Hilty, J. W.; Rennie, J. C.

    1973-01-01

    The author has identified the following significant results. Findings demonstrate the feasibility of delineating major terrain features, land uses, and crop species through computerized analyses. Channel 6 appears to give the most information for making separations of this type. By enlarging satellite imagery and visually comparing this with high altitude aerial photographs, locating small terrain features and cropland areas on satellite imagery is greatly facilitated. Forest types are discernable on the 2402 imagery with a #25 filter: pine stands have dark tones, hardwood stands have light tones, and pine-hardwood have intermediate tones. No textural differences are evident on this type of imagery. However, on the 2424 imagery with #89B filter, textural differences are evident but tonal differences are absent. Areas of considerable texture are interpreted as stands of high volume while areas of suppressed texture are of low volume. The 2402 imagery with a #57 filter appears to have little information of importance in timber inventory.

  7. Satellite Communication.

    ERIC Educational Resources Information Center

    Technology Teacher, 1985

    1985-01-01

    Presents a discussion of communication satellites: explains the principles of satellite communication, describes examples of how governments and industries are currently applying communication satellites, analyzes issues confronting satellite communication, links mathematics and science to the study of satellite communication, and applies…

  8. Under-utilization of health care services for infectious diseases syndromes in rural Azerbaijan: A cross-sectional study

    PubMed Central

    2011-01-01

    Background Infectious diseases present a potentially substantial yet undefined burden on the health of the adult Azerbaijani population. Efforts to quantify this burden in Azerbaijan are currently based almost exclusively on passive disease surveillance, and therefore hinge on the health utilization practices of the population. Understanding the prevalence of infectious syndromes and health utilization practices is paramount to disease surveillance, public health planning, and health care system reform. Methods A two-stage, probability proportional to size sampling design was used to select a representative sample of three regions of northern Azerbaijan with village populations less than 500 people. Demographic, clinical, and epidemiologic parameters were assessed using prevalence odds ratios, chi-squared, and the Fisher exact test. Associations with p < 0.10 were included in the regression analysis and removed by backward elimination. Respondents included 796 adults from 39 villages. Results Self-medication with antibiotics was the predominant utilization practice reported (19.4%). Only 1.3% of respondents reported seeing a health care provider for an infection, and 3.4% missed work or stayed in bed during the day in the last 5 years. In contrast, 338 illness episodes were reported in a 5 year period. Antibiotic use was significantly associated with gender, region, history of febrile illness, sleep disturbances, and arthritis controlling for age, ethnicity, and education. Influenza-like illness was the most prevalent infectious syndrome reported (33.3%). Conclusions We observed a remarkably low utilization of health services, despite reported symptoms that would merit use. Widespread availability of antibiotics may deter health care use, and may contribute to the development of antibiotic resistance in this population. Information on utilization of health services during an infection is essential for development of effective intervention strategies, and data on

  9. Study designs for identification of rare disease variants in complex diseases: the utility of family-based designs.

    PubMed

    Ionita-Laza, Iuliana; Ottman, Ruth

    2011-11-01

    The recent progress in sequencing technologies makes possible large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The results of such efforts depend heavily on the use of efficient study designs and analytical methods. We introduce here a unified framework for association testing of rare variants in family-based designs or designs based on unselected affected individuals. This framework allows us to quantify the enrichment in rare disease variants in families containing multiple affected individuals and to investigate the optimal design of studies aiming to identify rare disease variants in complex traits. We show that for many complex diseases with small values for the overall sibling recurrence risk ratio, such as Alzheimer's disease and most cancers, sequencing affected individuals with a positive family history of the disease can be extremely advantageous for identifying rare disease variants. In contrast, for complex diseases with large values of the sibling recurrence risk ratio, sequencing unselected affected individuals may be preferable.

  10. Clinical utility of digital dobutamine stress echocardiography in the noninvasive evaluation of coronary artery disease.

    PubMed

    Madu, E C; Ahmar, W; Arthur, J; Fraker, T D

    1994-05-23

    Exercise electrocardiography is an established mode of evaluation for patients with suspected coronary artery disease. It also provides prognostic information and guides therapeutic management in patients with established disease. However, some patients are unable to exercise because of orthopedic problems, neurologic diseases, peripheral vascular disease, or deconditioning. In the past, these patients have been referred for angiography to help assess their disease. Recently, however, new techniques to assess myocardial perfusion and/or function, including stress echocardiography, have been used in the noninvasive assessment of coronary artery disease in this group of patients. Echocardiography has been used in combination with different drugs, including dobutamine, dipyridamole, and adenosine. Dobutamine is probably the single most studied drug for stress echocardiography. Dobutamine stress echocardiography is a safe, feasible, and valuable technique for evaluating coronary artery disease.

  11. Selective biologics for ulcerative colitis and Crohn’s disease – clinical utility of vedolizumab

    PubMed Central

    Petkau, Jill MV; Eksteen, Bertus

    2016-01-01

    Inflammatory bowel disease (IBD) encompasses a cluster of different disease phenotypes which are broadly classified into ulcerative colitis and Crohn’s disease. Disease pathogenesis is driven by abnormal host immune responses to their resident gut microbiome in genetically susceptible individuals. Clinical disease features and outcomes are heterogenous and not unexpected as over 163 genetic loci are associated with disease susceptibility, and there are great variability in environmental exposures. Despite this variability, there has been relatively few efficacious therapies for particularly moderate-to-severe IBD. Treatment has been dominated by antitumor necrosis alpha agents with significant success but equally potentially serious adverse events. Therapeutic targeting of leucocyte trafficking has emerged as a viable alternative therapy, with vedolizumab being the lead compound. This review focuses primarily on its biological function as a selective gut immunotherapy, its safety and efficacy, and its emerging role as a mainstream therapy in managing IBD. PMID:27022240

  12. Assessment of health utilities and quality of life in patients with non-alcoholic fatty liver disease

    PubMed Central

    Sayiner, Mehmet; Stepanova, Maria; Pham, Huong; Noor, Bashir; Walters, Mercedes; Younossi, Zobair M

    2016-01-01

    Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease associated with increased liver-related mortality. Additionally, NAFLD could potentially impair health-related quality of life. Although an approved treatment for NAFLD does not exist, a number of new drugs for treatment of NAFLD are being developed. As the efficacy and safety of these regimens are being established, their cost-effectiveness, which requires the use of quality of life metrics and health utility scores to quality-adjusted outcomes, must also be assessed. The aim of this study was to report quality of life and health utilities in patients with NAFLD with and without cirrhosis for future use. Methods Patients with NAFLD were seen in an outpatient clinic setting. Each patient had extensive clinical data and completed the Short Form-36 (SF-36 V.1) questionnaire. The SF-6D health utility scores were calculated. Results There were 89 patients with the spectrum of NAFLD completed the SF-36 questionnaire: 59 with non-cirrhotic NAFLD and 30 with cirrhosis. Patients with NAFLD had significantly lower quality of life and health utility scores than the general population (all p<0.0001). Furthermore, patients with cirrhosis had lower quality of life and utility scores than non-cirrhotic NAFLD patients: SF-6D 0.660±0.107 in non-cirrhotic NAFLD vs 0.551±0.138 in cirrhotic NAFLD (p=0.0003). Conclusions Health utilities and quality of life scores are impaired in patients with cirrhotic NAFLD. These values should be used in cost-effectiveness analysis of the upcoming treatment regimens for advanced NAFLD.

  13. Assessment of health utilities and quality of life in patients with non-alcoholic fatty liver disease

    PubMed Central

    Sayiner, Mehmet; Stepanova, Maria; Pham, Huong; Noor, Bashir; Walters, Mercedes; Younossi, Zobair M

    2016-01-01

    Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease associated with increased liver-related mortality. Additionally, NAFLD could potentially impair health-related quality of life. Although an approved treatment for NAFLD does not exist, a number of new drugs for treatment of NAFLD are being developed. As the efficacy and safety of these regimens are being established, their cost-effectiveness, which requires the use of quality of life metrics and health utility scores to quality-adjusted outcomes, must also be assessed. The aim of this study was to report quality of life and health utilities in patients with NAFLD with and without cirrhosis for future use. Methods Patients with NAFLD were seen in an outpatient clinic setting. Each patient had extensive clinical data and completed the Short Form-36 (SF-36 V.1) questionnaire. The SF-6D health utility scores were calculated. Results There were 89 patients with the spectrum of NAFLD completed the SF-36 questionnaire: 59 with non-cirrhotic NAFLD and 30 with cirrhosis. Patients with NAFLD had significantly lower quality of life and health utility scores than the general population (all p<0.0001). Furthermore, patients with cirrhosis had lower quality of life and utility scores than non-cirrhotic NAFLD patients: SF-6D 0.660±0.107 in non-cirrhotic NAFLD vs 0.551±0.138 in cirrhotic NAFLD (p=0.0003). Conclusions Health utilities and quality of life scores are impaired in patients with cirrhotic NAFLD. These values should be used in cost-effectiveness analysis of the upcoming treatment regimens for advanced NAFLD. PMID:27648297

  14. The role and utility of faecal markers in inflammatory bowel disease.

    PubMed

    Lehmann, Frank S; Burri, Emanuel; Beglinger, Christoph

    2015-01-01

    Crohn's disease and ulcerative colitis are characterized by periods of symptomatic relapse and remission. Diagnosis and assessment of inflammatory bowel disease has so far been based on clinical evaluation, serum parameters, radiology and endoscopy. Faecal markers such as calprotectin or lactoferrin have emerged as new diagnostic tools to detect and monitor intestinal inflammation. This review focuses on their potential clinical applications and limitations in the management of inflammatory bowel disease. PMID:25553077

  15. Reduced healthcare utilization following successful hepatitis C virus treatment in HIV-co-infected patients with mild liver disease.

    PubMed

    Padam, P; Clark, S; Irving, W; Gellissen, R; Thomson, E; Main, J; Cooke, G S

    2016-02-01

    New direct-acting antivirals (DAA) for hepatitis C virus (HCV) infection have achieved high cure rates in many patient groups previously considered difficult-to-treat, including those HIV/HCV co-infected. The high price of these medications is likely to limit access to treatment, at least in the short term. Early treatment priority is likely to be given to those with advanced disease, but a more detailed understanding of the potential benefits in treating those with mild disease is needed. We hypothesized that successful HCV treatment within a co-infected population with mild liver disease would lead to a reduction in the use and costs of healthcare services in the 5 years following treatment completion. We performed a retrospective cohort study of HIV/HCV-co-infected patients without evidence of fibrosis/cirrhosis who received a course of HCV therapy between 2004 and 2013. Detailed analysis of healthcare utilization up to 5 years following treatment for each patient using clinical and electronic records was used to estimate healthcare costs. Sixty-three patients were investigated, of whom 48 of 63 (76.2%) achieved sustained virological response 12 weeks following completion of therapy (SVR12). Individuals achieving SVR12 incurred lower health utilization costs (£5,000 per-patient) compared to (£10 775 per-patient) non-SVR patients in the 5 years after treatment. Healthcare utilization rates and costs in the immediate 5 years following treatment were significantly higher in co-infected patients with mild disease that failed to achieve SVR12. These data suggest additional value to achieving cure beyond the prevention of complications of disease.

  16. Study of Drug Utilization Pattern for Skin Diseases in Dermatology OPD of an Indian Tertiary Care Hospital - A Prescription Survey

    PubMed Central

    Pathak, Anuj Kumar; Kumar, Subodh; Kumar, Manish; Dikshit, Harihar

    2016-01-01

    Introduction Skin diseases are the major contributors of disease burden in society. It affects individuals of all ages, neonates to elderly. Owing to its chronic nature, it causes serious impact on quality of life and financial status of the sufferer and his family. The problem gets compounded with the inappropriate and irrational use of medicines. Periodic prescription audit in form of drug utilization study is a way to improve the quality of prescription and curb the menace of irrational prescribing which has become a global phenomenon. Aim This study aims to determine the drug utilization pattern and assess the economic burden of the patient with skin disease. Materials and Methods It was a prospective, cross-sectional study conducted over a period of three months from January to March 2015 in newly diagnosed cases attending outpatient department of Skin and VD, IGIMS, Patna. The prescriptions were analysed with the help of descriptive statistics and results were expressed in percentage. Results Total 752 prescriptions were analysed during the study. Male patients were lesser as compared to female as male to female ratio was 0.88. Over 50% of patients were in adolescent age group i.e. 21-40 years. Acne (17.95%) was most common disease in the study population followed by eczema and Dermatophytosis. Among the drugs, antihistaminics (24.13%) were prescribed most frequently followed by antifungals and antibiotics. Topical agents constituted almost 60% of the total prescription and average number of drugs per prescription was 5.13, irrespective of the dosage forms prescribed. Conclusion This drug utilization study provides an insight to the prescriber regarding various issues related to polypharmacy, cost analysis and prevalent disease pattern in the region. This study also suggests periodic evaluation of prescription pattern to monitor and improve quality of prescription in other departments of the hospital. PMID:27042479

  17. The utility of satellite precipitation products for hydrologic prediction in topographically complex regions: The Chehalis River Basin, WA as a case study

    NASA Astrophysics Data System (ADS)

    Cao, Q.; Mehran, A.; Lettenmaier, D. P.; Mass, C.; Johnson, N.

    2015-12-01

    Accurate measurements of precipitation are of great importance in hydrologic predictions especially for floods, which are a pervasive natural hazard. One of the primary objectives of Global Precipitation Measurement (GPM) mission is to provide a basis for hydrologic predictions using satellite sensors. A major advance in GPM relative to the Tropical Rainfall Measuring Mission (TRMM) is that it observes atmospheric river (AR) events, most of which have landfall too far north to be tracked by TRMM. These events are responsible for most major floods along the U.S. West Coast. We address the question of whether, for hydrologic modeling purposes, it is better to use precipitation products derived directly from GPM and/or other precipitation fields from weather models that have assimilated satellite data. Our overall strategy is to compare different methods for prediction of flood and/or high flow events by different forcings on the hydrologic model. We examine four different configurations of the Distroibute Hydrology Soil Vegetation Model (DHSVM) over the Chehalis River Basin that use a) precipitation forcings based on gridded station data; b) precipitation forcings based on NWS WSR-88D data, c) forcings based from short-term precipitation forecasts using the Weather Research and Forecasting (WRF) mesoscale atmospheric model, and d) satellite-based precipitation estimates (TMPA and IMERG). We find that in general, biases in the radar and satellite products result in much larger errors than with either gridded station data or WRF forcings, but if these biases are removed, comparable performance in flood predictions can be achieved by Satellite-based precipitation estimates (TMPA and IMERG).

  18. Utilizing Dental Electronic Health Records Data to Predict Risk for Periodontal Disease.

    PubMed

    Thyvalikakath, Thankam P; Padman, Rema; Vyawahare, Karnali; Darade, Pratiksha; Paranjape, Rhucha

    2015-01-01

    Periodontal disease is a major cause for tooth loss and adversely affects individuals' oral health and quality of life. Research shows its potential association with systemic diseases like diabetes and cardiovascular disease, and social habits such as smoking. This study explores mining potential risk factors from dental electronic health records to predict and display patients' contextualized risk for periodontal disease. We retrieved relevant risk factors from structured and unstructured data on 2,370 patients who underwent comprehensive oral examinations at the Indiana University School of Dentistry, Indianapolis, IN, USA. Predicting overall risk and displaying relationships between risk factors and their influence on the patient's oral and general health can be a powerful educational and disease management tool for patients and clinicians at the point of care.

  19. Efficiency of CCR5 coreceptor utilization by the HIV quasispecies increases over time, but is not associated with disease progression.

    PubMed

    Redd, Andrew D; Laeyendecker, Oliver; Kong, Xiangrong; Kiwanuka, Noah; Lutalo, Tom; Huang, Wei; Gray, Ronald H; Wawer, Maria J; Serwadda, David; Eshleman, Susan H; Quinn, Thomas C

    2012-03-01

    CCR5 is the primary coreceptor for HIV entry. Early after infection, the HIV viral population diversifies rapidly into a quasispecies. It is not known whether the initial efficiency of the viral quasispecies to utilize CCR5 is associated with HIV disease progression or if it changes in an infected individual over time. The CCR5 and CXCR4 utilization efficiencies (R5-UE and X4-UE) of the HIV quasispecies were examined using a pseudovirus, single-round infection assay for samples obtained from known seroconverters from Rakai district, Uganda (n=88). Initial and longitudinal R5-UE values were examined to assess the association of R5-UE with HIV disease progression using multivariate Cox proportional hazard models. Longitudinal samples were analyzed for 35 seroconverters who had samples available from multiple time points. There was no association between initial or longitudinal changes in R5-UE and the hazard of HIV disease progression (p=0.225 and p=0.942, respectively). In addition, R5-UE increased significantly over time after HIV seroconversion (p<0.001), regardless of HIV subtype or the emergence of CXCR4-tropic virus. These data demonstrate that the R5-UE of the viral quasispecies early in HIV infection is not associated with disease progression, and that R5-UE levels increase in HIV-infected individuals over time.

  20. Utility of R0 as a predictor of disease invasion in structured populations

    USGS Publications Warehouse

    Cross, P.C.; Johnson, P.L.F.; Lloyd-Smith, J. O.; Getz, W.M.

    2007-01-01

    Early theoretical work on disease invasion typically assumed large and well-mixed host populations. Many human and wildlife systems, however, have small groups with limited movement among groups. In these situations, the basic reproductive number, R0, is likely to be a poor predictor of a disease pandemic because it typically does not account for group structure and movement of individuals among groups. We extend recent work by combining the movement of hosts, transmission within groups, recovery from infection and the recruitment of new susceptibles into a stochastic model of disease in a host metapopulation. We focus on how recruitment of susceptibles affects disease invasion and how population structure can affect the frequency of superspreading events (SSEs). We show that the frequency of SSEs may decrease with the reduced movement and the group sizes due to the limited number of susceptible individuals available. Classification tree analysis of the model results illustrates the hierarchical nature of disease invasion in host metapopulations. First, the pathogen must effectively transmit within a group (R0 > 1), and then the pathogen must persist within a group long enough to allow for movement among the groups. Therefore, the factors affecting disease persistence - such as infectious period, group size and recruitment of new susceptibles - are as important as the local transmission rates in predicting the spread of pathogens across a metapopulation. ?? 2006 The Royal Society.

  1. An Update on the Utility of Coronary Artery Calcium Scoring for Coronary Heart Disease and Cardiovascular Disease Risk Prediction.

    PubMed

    Kianoush, Sina; Al Rifai, Mahmoud; Cainzos-Achirica, Miguel; Umapathi, Priya; Graham, Garth; Blumenthal, Roger S; Nasir, Khurram; Blaha, Michael J

    2016-03-01

    Estimating cardiovascular disease (CVD) risk is necessary for determining the potential net benefit of primary prevention pharmacotherapy. Risk estimation relying exclusively on traditional CVD risk factors may misclassify risk, resulting in both undertreatment and overtreatment. Coronary artery calcium (CAC) scoring personalizes risk prediction through direct visualization of calcified coronary atherosclerotic plaques and provides improved accuracy for coronary heart disease (CHD) or CVD risk estimation. In this review, we discuss the most recent studies on CAC, which unlike historical studies, focus sharply on clinical application. We describe the MESA CHD risk calculator, a recently developed CAC-based 10-year CHD risk estimator, which can help guide preventive therapy allocation by better identifying both high- and low-risk individuals. In closing, we discuss calcium density, regional distribution of CAC, and extra-coronary calcification, which represent the future of CAC and CVD risk assessment research and may lead to further improvements in risk prediction.

  2. Utilization of satellite-derived estimates of meteorological and land surface characteristics in the Land Surface Model for vast agricultural region territory

    NASA Astrophysics Data System (ADS)

    Muzylev, Eugene; Startseva, Zoya; Uspensky, Alexander; Volkova, Elena

    2015-04-01

    The method has been elaborated to evaluate the water and heat regime characteristics of the territory on a regional scale for the vegetation season based on a physical-mathematical model of water and heat exchange between vegetation covered land surface and atmosphere (LSM, Land Surface Model) appropriate for using satellite information on land surface and meteorological conditions. The developed model is intended for calculating soil water content, evapotranspiration (evaporation from bare soil and transpiration by vegetation), vertical water and heat fluxes as well as land surface and vegetation cover temperatures and vertical distributions of temperature and moisture in the active soil layer. Parameters of the model are soil and vegetation characteristics and input variables are meteorological characteristics. Their values have been obtained from ground-based observations at agricultural meteorological stations and satellite-based measurements by scanning radiometers AVHRR/NOAA, MODIS/EOS Terra and Aqua and SEVIRI (geostationary satellites Meteosat-9, -10). The AVHRR data have been used to build the estimates of three types of land surface temperature (LST): land skin temperature Tsg, air temperature at a level of vegetation cover Ta and efficient radiation temperature Tseff, emissivity E, normalized vegetation index NDVI, vegetation cover fraction B, leaf area index LAI, and precipitation. The set of estimates derived from MODIS data has comprised values of LST Tls, E, NDVI and LAI. The SEVIRI-based retrievals have included Tls, Ta, Е at daylight and nighttime, LAI (daily) and precipitation. The case study has been carried out for agricultural Central Black Earth region of the European Russia of 227,300 sq.km containing 7 regions of the Russian Federation for years 2009-2013 vegetation seasons. Estimates of described characteristics have been built with the help of the developed original and improved pre-existing methods and technologies of thematic processing

  3. A correlative study of simultaneously measured He(++) fluxes in the solar wind and in the magnetosphere utilizing Imp-1 and 1971-089A satellite data

    NASA Technical Reports Server (NTRS)

    Shelley, E. G.

    1975-01-01

    Simultaneously measured He(++) fluxes in the solar wind and in the magnetosphere were studied using data from the plasma spectrometer on the Imp I satellite and the energetic ion mass spectrometer on the low altitude polar orbiting satellite 1971-89A. A detailed comparison of the He(++) energy spectra measured simultaneously in the solar wind and in the low altitude dayside polar cusp on March 7, 1972 was made. The energy-per-unit-charge range of the energetic ion mass spectrometer on board the polar orbiting satellite was 700 eV to 12 keV. Within this range there was a clear maximum in the He(++) energy spectrum at approximately 1.5 keV/nucleon. There was not a clearly defined maximum in the H(+) spectrum, but the data were consistent with a peak between 0.7 and 1.0 keV/nucleon. Both spectra could be reasonably well fit with a convecting Maxwellian plus a high energy tail; however, the mean velocity for He(++) distribution was significantly greater than that for the H(+) distribution. The simultaneous solar wind measurements showed the mean velocities for both ion species to be approximately 600 km/sec. The discrepancies between the relative velocity distributions in the low altitude cusp and those in the solar wind are consistent with a potential difference of approximately 1.4 kV along their flow direction between the two points of observation.

  4. Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy.

    PubMed

    Manix, Marc; Kalakoti, Piyush; Henry, Miriam; Thakur, Jai; Menger, Richard; Guthikonda, Bharat; Nanda, Anil

    2015-11-01

    Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative condition with a rapid disease course and a mortality rate of 100%. Several forms of the disease have been described, and the most common is the sporadic type. The most challenging aspect of this disease is its diagnosis-the gold standard for definitive diagnosis is considered to be histopathological confirmation-but newer tests are providing means for an antemortem diagnosis in ways less invasive than brain biopsy. Imaging studies, electroencephalography, and biomarkers are used in conjunction with the clinical picture to try to make the diagnosis of CJD without brain tissue samples, and all of these are reviewed in this article. The current diagnostic criteria are limited; test sensitivity and specificity varies with the genetics of the disease as well as the clinical stage. Physicians may be unsure of all diagnostic testing available, and may order outdated tests or prematurely request a brain biopsy when the diagnostic workup is incomplete. The authors review CJD, discuss the role of brain biopsy in this patient population, provide a diagnostic pathway for the patient presenting with rapidly progressive dementia, and propose newer diagnostic criteria. PMID:26646926

  5. Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy.

    PubMed

    Manix, Marc; Kalakoti, Piyush; Henry, Miriam; Thakur, Jai; Menger, Richard; Guthikonda, Bharat; Nanda, Anil

    2015-11-01

    Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative condition with a rapid disease course and a mortality rate of 100%. Several forms of the disease have been described, and the most common is the sporadic type. The most challenging aspect of this disease is its diagnosis-the gold standard for definitive diagnosis is considered to be histopathological confirmation-but newer tests are providing means for an antemortem diagnosis in ways less invasive than brain biopsy. Imaging studies, electroencephalography, and biomarkers are used in conjunction with the clinical picture to try to make the diagnosis of CJD without brain tissue samples, and all of these are reviewed in this article. The current diagnostic criteria are limited; test sensitivity and specificity varies with the genetics of the disease as well as the clinical stage. Physicians may be unsure of all diagnostic testing available, and may order outdated tests or prematurely request a brain biopsy when the diagnostic workup is incomplete. The authors review CJD, discuss the role of brain biopsy in this patient population, provide a diagnostic pathway for the patient presenting with rapidly progressive dementia, and propose newer diagnostic criteria.

  6. Utility of quantitative ultrasound for tracking the progression of polycystic kidney disease

    NASA Astrophysics Data System (ADS)

    Hall, Timothy J.; Khant, Htet A.; Insana, Michael F.; Wood, John G.; Zhu, Yanning; Preston, David; Cowley, Benjamin D.

    2000-04-01

    We are combining techniques of quantitative ultrasonic imaging to study polycystic kidney disease (PKD) as the disease progresses to renal failure. Our goal is to use ultrasound noninvasively to detect morphological changes early in the disease process when interventions are most likely to be successful and prior to a significant loss in renal function. We are examining the kidneys of normal rats and those with PKD at various ages with several techniques to obtain comprehensive knowledge of the disease progression. The Han:SPRD rat inherits PKD as an autosomal dominant trait (ADPKD) that closely mimics ADPKD in humans. Changes in renal function are assessed using tracer kinetics (DTPA) and IOH clearance). Ultrasonic techniques, based on measurements of acoustic backscatter coefficients and parameters derived from these measurements, are sensitive to microscopic changes in the tissue morphology. Elasticity imaging is used to study the changes in the tissue macrostructure. All acoustic measurements are made using a state-of-the-art clinical imaging system (Siemens Elegra). Our results show that ultrasonic techniques are very sensitive to early changes in renal microstructure and macrostructure. Ultrasound can be used to detect changes in the renal cortex long before there is a measurable loss of renal function. These techniques are also useful for monitoring the progression of the disease. Most importantly, these techniques are noninvasive and directly applicable to humans.

  7. The clinical utility of FibroScan(®) as a noninvasive diagnostic test for liver disease.

    PubMed

    Wilder, Julius; Patel, Keyur

    2014-01-01

    An important aspect of managing chronic liver disease is assessing for evidence of fibrosis. Historically, this has been accomplished using liver biopsy, which is an invasive procedure associated with risk for complications and significant sampling and observer error, limiting the accuracy for determination of fibrosis stage. Hence, several serum biomarkers and imaging methods for noninvasive assessment of liver fibrosis have been developed. In this article, we review the current literature on an important noninvasive imaging modality to measure tissue elastography (FibroScan(®)). This ultrasound-based technique is now increasingly available in many countries and has been shown to be a reliable and safe noninvasive means of assessing disease severity in chronic liver disease of varying etiology.

  8. (F)Utility of invasive haemodynamic measurements to guide percutaneous intervention in chronic coronary artery disease.

    PubMed

    Seiler, Christian

    2015-01-01

    Percutaneous coronary intervention (PCI) in chronic stable coronary artery disease has not been shown to reduce the incidence of myocardial infarction or death. There is, however, evidence that the outcome from PCI is dependent on the amount of myocardial ischaemia. This review provides an overview of coronary circulatory pathophysiology and focuses on fractional flow reserve from a semantical, conceptual and practical point of view.

  9. The Clinical Utility of a Low Serum Ceruloplasmin Measurement in the Diagnosis of Wilson Disease.

    PubMed

    Kelly, D; Crotty, G; O'Mullane, J; Stapleton, M; Sweeney, B; O'Sullivan, S S

    2016-01-01

    The first step in screening for potential Wilson disease is serum ceruloplasmin testing, whereby a level of less than 0.2g/L is suggestive of the disease. We aimed to determine what proportion of an Irish population had a low ceruloplasmin level, whether low measurements were appropriately followed-up and what were the clinical outcomes. We conducted a retrospective review of all serum ceruloplasmin measurements between August 2003 and October 2009 in a large tertiary referral centre in Southern Ireland. Clinical data, serum ceruloplasmin, liver function tests, urinary copper and liver biopsy reports were all recorded where available. 1573 patients had a serum ceruloplasmin measurement during the 7-year study period. 96 patients (6.1%) had a ceruloplasmin level < 0.2g/L and of these only 3 patients had Wilson disease. There was only 1 new diagnosis. Only 27 patients (28.1%) had some form of confirmatory testing performed. In our centre's experience, the positive predictive value of a significantly low ceruloplasmin level is 11.1% (95% CI 2.91-30.3%). In practice a low serum ceruloplasmin measurement is often not followed by appropriate confirmatory testing. Measuring serum ceruloplasmin as a singular diagnostic test for Wilson disease or as part of the battery of unselected liver screening tests is inappropriate and low-yield.

  10. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment

    PubMed Central

    ROBINSON, ANDREW P.; HARP, CHRISTOPHER T.; NORONHA, AVERTANO; MILLER, STEPHEN D.

    2014-01-01

    While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal models are essential in understanding the induction and pathogenesis of the disease and to develop therapeutic strategies that limit disease progression and eventually lead to effective treatments for the human disease. Several different models of MS exist, but by far the best understood and most commonly used is the rodent model of experimental autoimmune encephalomyelitis (EAE). This model is typically induced by either active immunization with myelin-derived proteins or peptides in adjuvant or by passive transfer of activated myelin-specific CD4+ T lymphocytes. Mouse models are most frequently used because of the inbred genotype of laboratory mice, their rapid breeding capacity, the ease of genetic manipulation, and availability of transgenic and knockout mice to facilitate mechanistic studies. Although not all therapeutic strategies for MS have been developed in EAE, all of the current US Food and Drug Administration (FDA)-approved immunomodulatory drugs are effective to some degree in treating EAE, a strong indicator that EAE is an extremely useful model to study potential treatments for MS. Several therapies, such as glatiramer acetate (GA: Copaxone), and natalizumab (Tysabri), were tested first in the mouse model of EAE and then went on to clinical trials. Here we discuss the usefulness of the EAE model in understanding basic disease pathophysiology and developing treatments for MS as well as the potential drawbacks of this model. PMID:24507518

  11. Alberta's systems approach to chronic disease management and prevention utilizing the expanded chronic care model.

    PubMed

    Delon, Sandra; Mackinnon, Blair

    2009-01-01

    Alberta's integrated approach to chronic disease management programming embraces client-centred care, supports self-management and facilitates care across the continuum. This paper presents strategies implemented through collaboration with primary care to improve care of individuals with chronic conditions, evaluation evidence supporting success and lessons learned from the Alberta perspective.

  12. The Clinical Utility of SUDOSCAN in Chronic Kidney Disease in Chinese Patients with Type 2 Diabetes

    PubMed Central

    Luk, Andrea O. Y.; Ozaki, Risa; Chung, Harriet H. Y.; Wong, Rebecca Y. M.; So, Wing-Yee; Chow, Francis C. C.

    2015-01-01

    There are gaps between recommendations on regular screening for diabetic kidney disease (DKD) and clinical practice especially in busy and low resource settings. SUDOSCAN (Impeto Medical, Paris, France) is a non-invasive technology for assessing sudomotor function using reverse iontophoresis and chronoamperometry which detects abnormal sweat gland function. Vasculopathy and neuropathy share common risk factors and we hypothesized that SUDOSCAN may be used to detect chronic kidney disease (CKD). Between 2012 and 2013, SUDOSCAN was performed in a consecutive cohort of 2833 Hong Kong Chinese adults with type 2 diabetes. Chronic kidney disease was defined as estimated glomerular filtration rate <60 ml/min/1.73m2. In this cross-sectional cohort (mean age 58.6±9.5 years, 55.7% male, median disease duration 8 [interquartile range 3–14] years), 5.8% had CKD. At a cut-off SUDOSCAN-DKD score of 53, the test had sensitivity of 76.7%, specificity of 63.4% and positive likelihood ratio of 2.1 to detect CKD. The area under receiver operating characteristic curve for CKD was 0.75 (95% confidence interval 0.72–0.79). Patients without CKD but low score had worse risk factors and complications than those with high score. We conclude that SUDOSCAN may be used to detect patients at risk of impaired renal function as part of a screening program in Chinese population, especially in outreach or low resource settings. PMID:26270544

  13. A Global Information Utility.

    ERIC Educational Resources Information Center

    Block, Robert S.

    1984-01-01

    High-powered satellites, along with other existing technologies, make possible a world information utility that could distribute virtually limitless information to every point on earth. The utility could distribute information for business, government, education, and entertainment. How the utility would work is discussed. (RM)

  14. Use of Satellite data by the USDA to Forecast Global Vector-borne Human and Animal Diseases

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In recent years satellite remote sensing has been used increasingly for public health applications. In this symposium, experts from four government departments and agencies with major roles in leading and promoting such applications will discuss the state of the art of using remote sensing for epide...

  15. Illness-specific anxiety: implications for functioning and utilization of medical services in adolescents with inflammatory bowel disease.

    PubMed

    Reigada, Laura C; Bruzzese, Jean-Marie; Benkov, Keith J; Levy, Joseph; Waxman, Amanda R; Petkova, Eva; Warner, Carrie Masia

    2011-07-01

    PURPOSE. Adolescents with inflammatory bowel disease (IBD) may be at heightened risk for developing anxiety and depression. This cross-sectional pilot study examined the relationship between anxiety and depression and health-related behaviors. METHODS. Thirty-six adolescents with diagnosed IBD, ages 12-17, and their parents were recruited from two pediatric gastroenterology medical centers. RESULTS. Clinical levels of anxiety (22%) and depressive symptoms (30%) were reported by patients. Regression analyses revealed that IBD-specific anxiety was significantly associated with greater utilization of medical services and worsened psychosocial functioning. PRACTICE IMPLICATIONS. Results provide preliminary support that IBD-specific anxiety may play an important role in disease management, yet concerns are rarely systematically assessed by health professionals.

  16. The clinical utility of bronchoalveolar lavage in interstitial lung disease - is it really useful?

    PubMed

    Meyer, Keith C

    2014-04-01

    Bronchoalveolar lavage (BAL) can be a very useful tool in the diagnosis of interstitial lung disease, but BAL must be performed properly and the retrieved BAL fluid adequately processed and analyzed to allow accurate conclusions to be drawn from BAL analysis. A differential cell count of nucleated immune cells can show cell patterns that suggest or support certain diagnoses, and other testing (stains and cultures for infectious pathogens, malignant cell cytology) can be performed on BAL fluid that can also aid in diagnosis. When combined with the results of a careful history, physical examination, thoracic imaging, and other pertinent laboratory testing, the BAL analysis may allow a confident diagnosis of a specific interstitial lung disease to be made without proceeding to more invasive testing (e.g., surgical lung biopsy) that is associated with increased risk of complications.

  17. The Utility of Cardiopulmonary Exercise Testing to Detect and Track Early-Stage Ischemic Heart Disease

    PubMed Central

    Chaudhry, Sundeep; Arena, Ross A.; Hansen, James E.; Lewis, Gregory D.; Myers, Jonathan N.; Sperling, Laurence S.; LaBudde, Brian D.; Wasserman, Karlman

    2010-01-01

    Evidence demonstrating the potential value of noninvasive cardiopulmonary exercise testing (CPET) to accurately detect exercise-induced myocardial ischemia is emerging. This case-based concept report describes CPET abnormalities in an asymptomatic at-risk man with suspected early-stage ischemic heart disease. When CPET was repeated 1 year after baseline assessment, his cardiovascular function had worsened, and an anti-atherosclerotic regimen was initiated. When the patient was retested after 3.3 years, the diminished left ventricular function had reversed with pharmacotherapy directed at decreasing cardiovascular events in patients with coronary artery disease. Thus, in addition to identifying appropriate patients in need of escalating therapy for atherosclerosis, CPET was useful in monitoring progression and reversal of abnormalities of the coronary circulation in a safe and cost-effective manner without the use of radiation. Serial CPET parameters may be useful to track changes marking the progression and/or regression of the underlying global ischemic burden. PMID:20884826

  18. Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease.

    PubMed

    Zmora, Niv; Zeevi, David; Korem, Tal; Segal, Eran; Elinav, Eran

    2016-01-13

    The genomic revolution enabled the clinical inclusion of an immense body of person-specific information to an extent that is revolutionizing medicine and science. The gut microbiome, our "second genome," dynamically integrates signals from the host and its environment, impacting health and risk of disease. Herein, we summarize how individualized characterization of the microbiome composition and function may assist in personalized diagnostic assessment, risk stratification, disease prevention, treatment decision-making, and patients' follow up. We further discuss the limitations, pitfalls, and challenges that the microbiome field faces in integrating patient-specific microbial data into the clinical realm. Finally, we highlight how recent insights into personalized modulation of the microbiome, by nutritional and pre-, pro-, and post-biotic intervention, may lead to development of individualized approaches that may enable us to harness the microbiome as a central precision medicine target.

  19. Antiretroviral Therapy and Health Care Utilization: A Study of Privately Insured Men and Women with HIV Disease

    PubMed Central

    Hellinger, Fred J; Encinosa, William E

    2004-01-01

    Objective To compare the use of antiretroviral therapy and other health care resources by women and men with HIV disease who are privately insured. Data Sources Data were obtained from the MarketScan Commercial Claims and Encounter Database produced by the Medstat Group, Inc., of Ann Arbor, Michigan. This database includes eligibility files as well as claims data for inpatient care, outpatient care, physician services, and prescription drugs for enrollees in employer-sponsored benefit plans for 24 large employers around the nation. Study Design Examine utilization by 2,026 privately insured persons (1,494 men and 532 women) with HIV disease in calendar year 2000 under the age of 65. Principal Findings Using a simple comparison, we found that 71 percent of men (68.7 to 73.3 percent is 95 percent confidence interval) and 39 percent of women (35.1 to 43.5 percent is 95 percent confidence interval) with HIV disease received antiretroviral therapy. We also found that the average annual drug cost was $9,037 for a man ($8,372 to $9,702 is 95 percent confidence interval) and $3,893 for a woman ($3,476 to $4,490 is 95 percent confidence interval). Furthermore, we found that the out-of-pocket expenses comprised 10 percent of total expenses for men ($1,617 out of $16,405) and 4 percent for women ($405 out of $10,397). Conclusion There are major differences in the utilization and cost of health care between privately insured men and women with HIV disease. PMID:15230936

  20. What is The Utility of Electrophysiological Study in Elderly Patients with Syncope and Heart Disease?

    PubMed Central

    Aslam, Rumas; Girerd, Nicolas; Brembilla-Perrot, Beatrice

    2016-01-01

    Background Syncope in elderly patients with heart disease is a growing problem. Its aetiological diagnosis is often difficult. We intended to investigate the value of the electrophysiological study (EPS) in old patients with syncope and heart disease. Methods EPS was performed in 182 consecutive patients with syncope and heart disease, among whom 62 patients were ≥75 years old and 120 patients <75. Results Left ventricular ejection fraction was 43.9±11.7% in patients ≥75 and 41.1±12.6% in patients <75. During EPS, induced sustained ventricular arrhythmias were as frequent in both groups (27.4% in patients ≥75 versus 27.5% in patients <75, p=0.99) whereas AV conduction abnormalities were more frequent in older patients (37.1% in patients ≥75 versus 18.3% in patients<75, p<0.005). Syncope remained unexplained in 35.5% of patients ≥75 and in 51.7% of patients <75 (p<0.04). ICD was more likely to be implanted in younger patients than in patients ≥75 years (37.5% vs 21% respectively, p<0.009). During a mean follow-up period of 3.3±3 years, the 4-year-survival rate was 66.9±6.8 % in patients ≥75 and 75.9±6.2 % in patients <75 years. The main cause of death was heart failure in both groups. The factors related to a worse outcome in a multivariate analysis were low LVEF and higher age. Conclusion Complete EPS allows the identification of treatable causes in a high proportion of elderly patients with syncope and heart disease. Yet, the prognosis of these patients is mainly related to LVEF and age. PMID:25852241

  1. Mobile satellite service communications tests using a NASA satellite

    NASA Technical Reports Server (NTRS)

    Chambers, Katherine H.; Koschmeder, Louis A.; Hollansworth, James E.; ONeill, Jack; Jones, Robert E.; Gibbons, Richard C.

    1995-01-01

    Emerging applications of commercial mobile satellite communications include satellite delivery of compact disc (CD) quality radio to car drivers who can select their favorite programming as they drive any distance; transmission of current air traffic data to aircraft; and handheld communication of data and images from any remote corner of the world. Experiments with the enabling technologies and tests and demonstrations of these concepts are being conducted before the first satellite is launched by utilizing an existing NASA spacecraft.

  2. Utility of renal biopsy in the clinical management of renal disease.

    PubMed

    Dhaun, Neeraj; Bellamy, Christopher O; Cattran, Daniel C; Kluth, David C

    2014-05-01

    Characterizing chronic kidney disease (CKD) at all stages is an essential part of rational management and the renal biopsy plays a key role in defining the processes involved. There remain no global guidelines available to the renal community on indications for this important diagnostic, prognostic, and relatively safe test. Although most nephrologists recognize several clear indications for a renal biopsy, it is still underutilized. It not only helps the clinician to manage the patient with CKD, but it can also help clarify the epidemiology of CKD, and aid research into the pathobiology of disease with the aim of discovering new therapies. It may be useful for instance in elderly patients with CKD, those with diabetes and presumed 'hypertensive nephropathy', and in some patients with advanced CKD as part of the pretransplant work-up. In some populations (for example, immunoglobulin A nephropathy and ANCA vasculitis), renal biopsy allows disease classification that may predict CKD progression and response to therapy. For the individual, interval renal biopsy may be of use in providing ongoing therapeutic and prognostic information. Molecular advances will change the landscape of renal pathology and add a new dimension to the diagnostic precision of kidney biopsy. Organizing the multiplicity of information available in a renal biopsy to maximize benefits to the patient, as well as to the epidemiologist and researcher, is one of the challenges that face the nephrology community.

  3. Immunofluorescence Patterns in Selected Dermatoses, Including Blistering Skin Diseases Utilizing Multiple Fluorochromes

    PubMed Central

    Abreu-Velez, Ana Maria; Calle-Isaza, Juliana; Howard, Michael S.

    2015-01-01

    Background: Autoimmune vesiculobullous disorders represent a heterogeneous group of dermatoses whose diagnosis is made based on clinical history, histologic features, and immunopathologic features. The most commonly used techniques for the diagnosis of these diseases are direct and indirect immunofluorescence (DIF and IIF), including salt-split processing. NaCl split skin is used to determine the level of blister formation, and the localization of autoantibodies relative to the split. Classically, immunofluorescence has been performed with one fluorochrome in the diagnosis of autoimmune bullous skin diseases. Aims: To compare DIF and IIF of the skin, using a single fluorochrome versus multiple fluorochromes. Materials and Methods: We studied 20 autoimmune skin disease cases using fluorescein isothiocyanate (FITC) alone, in comparison to multiple fluorochromes (with or without DNA counterstaining). Results: The use of multiple fluorochromes helped to simultaneously visualize reactivity in multiple skin areas, in contrast to using FITC alone. Conclusions: Using multiple fluorochromes allows simultaneous labeling of two or more antigens within the same cell/or tissue section, assists in colocalization of unknown antigens with known molecules, and helps in ruling out “background” staining. PMID:26605203

  4. Adding Specialized Clinics for Remote-Dwellers with Chronic Kidney Disease: A Cost-Utility Analysis

    PubMed Central

    Wiebe, Natasha; Klarenbach, Scott W.; Chui, Betty; Ayyalasomayajula, Bharati; Hemmelgarn, Brenda R.; Jindal, Kailash; Manns, Braden; Tonelli, Marcello

    2012-01-01

    Summary Background and objectives This study aimed to determine whether opening a new clinic in a remote region would be a cost-effective means of improving care for remote-dwellers with CKD. Design, setting, participants, & measurements This study is a cost-utility analysis from a public payer’s perspective over a lifetime horizon, using administrative data from a large cohort of adults with stage 3b-4 CKD in Alberta, Canada. The association between the distance from each simulated patient’s residence and the practice location of the closest nephrologist and clinical outcomes (quality of care, hospitalization, dialysis, and death) were examined. A Markov 6-month cycle economic decision model was analyzed; estimates of the effect of a new clinic were based on the association between residence location, resource use, and outcomes. Costs are reported in 2009 Canadian dollars. Results The costs for equipping and operating a clinic for 321 remote-dwelling patients were estimated at $25,000 and $250,000/yr, respectively. The incremental cost-utility ratios (ICURs) ranged from $4000 to $8000/quality-adjusted life-year under most scenarios. However, if reducing distance to nephrologist care does not alter mortality or hospitalization among remote-dwellers, the cost-effectiveness becomes less attractive. All other one-way sensitivity analyses had negligible effects on the ICUR. Conclusions Given the low costs of equipping and operating new clinics, and the very attractive ICUR relative to other currently funded interventions, establishing new clinics for remote-dwellers could play an important role in efficiently improving outcomes for patients with CKD. High-quality controlled studies are required to confirm this hypothesis. PMID:22076876

  5. Cost-utility of enoxaparin compared with unfractionated heparin in unstable coronary artery disease

    PubMed Central

    Nicholson, Tricia; McGuire, Alistair; Milne, Ruairidh

    2001-01-01

    Background Low molecular weight heparins hold several advantages over unfractionated heparin including convenience of administration. Enoxaparin is one such heparin licensed in the UK for use in unstable coronary artery disease (unstable stable angina and non-Q wave myocardial infarction). In these patients, two large randomised controlled trials and their meta-analysis showed small benefits for enoxaparin over unfractionated heparin at 30–43 days and potentially at one year. We found no relevant published full economic evaluations, only cost studies, one of which was conducted in the UK. The other studies, from the US, Canada and France, are difficult to interpret since their resource use and costs may not reflect UK practice. Methods We aimed to compare the benefits and costs of short-term treatment (two to eight days) with enoxaparin and unfractionated heparin in unstable coronary artery disease. We used published data sources to estimate the incremental cost per quality adjusted life year (QALY), adopting a NHS perspective and using 1998 prices. Results The base case was a 0.013 QALY gain and net cost saving of £317 per person treated with enoxaparin instead of unfractionated heparin. All but one sensitivity analysis showed net savings and QALY gains, the exception (the worst case) being a cost per QALY of £3,305. Best cases were a £495 saving and 0.013 QALY gain, or a £317 saving and 0.014 QALY gain per person. Conclusions Enoxaparin appears cost saving compared with unfractionated heparin in patients with unstable coronary artery disease. However, cost implications depend on local revascularisation practice. PMID:11701090

  6. Utilization of Feeding Tubes in the Management of Feline Chronic Kidney Disease.

    PubMed

    Ross, Sheri

    2016-11-01

    Esophagostomy feeding tubes are useful, and in many cases essential, for the comprehensive management of cats with moderate to advanced chronic kidney disease (CKD). They should be considered a lifelong therapeutic appliance to facilitate the global management of cats with CKD thus providing improved therapeutic efficacy and quality-of-life. Esophagostomy tubes facilitate the maintenance of adequate hydration and increase owner compliance by facilitating the administration of medications. Finally, feeding tubes provide a means to deliver a stage-appropriate dietary prescription for cats with CKD and maintain an adequate nutritional plane in a patient that otherwise would be subject to chronic wasting.

  7. Utilization of Feeding Tubes in the Management of Feline Chronic Kidney Disease.

    PubMed

    Ross, Sheri

    2016-11-01

    Esophagostomy feeding tubes are useful, and in many cases essential, for the comprehensive management of cats with moderate to advanced chronic kidney disease (CKD). They should be considered a lifelong therapeutic appliance to facilitate the global management of cats with CKD thus providing improved therapeutic efficacy and quality-of-life. Esophagostomy tubes facilitate the maintenance of adequate hydration and increase owner compliance by facilitating the administration of medications. Finally, feeding tubes provide a means to deliver a stage-appropriate dietary prescription for cats with CKD and maintain an adequate nutritional plane in a patient that otherwise would be subject to chronic wasting. PMID:27499006

  8. Potential therapeutic utility of mesenchymal stem cells in inflammatory bowel disease in mice.

    PubMed

    Abdel Salam, Ahmed G; Ata, Hazem M; Salman, Tarek M; Rashed, Laila A; Sabry, Dina; Schaalan, Mona F

    2014-10-01

    Mesenchymal stem cells (MSCs) were found to provide an effective therapeutic role in inflammatory diseases by modulating inflammatory responses and tissue regeneration by their differentiation ability. The present work sought to demonstrate the potential therapeutic use of MSCs in treating chronic inflammatory bowel disease (IBD) in mice. A new model to induce chronic IBD based on alternative administration periods of Dextran Sodium Sulfate (DSS) was established. Mice were divided into 2 groups; one was treated with MSCs and the other was treated with phosphate-buffered saline (PBS). Assessment of therapeutic efficacy of MSCs was by measuring weight, stool scoring, histopathological examination, and measuring the gene expression of inflammatory markers: Interleukin-23 (IL-23), Tumor necrosis factor-α (TNF-α), Interferon-γ (IFN-γ), and Intercellular adhesion molecule-1 (ICAM-1). The results showed that DSS administration causes bloody and watery stool, weight loss, and altered histopathologic picture. MSC treated mice showed a significant improvement in stool condition, weight gain, and normal histopathologic picture compared to the PBS treated mice. Moreover, gene expressions of inflammatory markers in the intestines of the MSC treated mice were also significantly lower than those of the PBS treated mice. In conclusion, the data here showed that MSCs have a clear potential efficacy in the treatment for IBD, as their immune modulation effects include inhibition in the expression of key inflammatory markers that each plays an important role in the pathogenesis of IBD.

  9. Vaccine-preventable disease and the under-utilization of immunizations in complex humanitarian emergencies.

    PubMed

    Close, Ryan M; Pearson, Catherine; Cohn, Jennifer

    2016-09-01

    Complex humanitarian emergencies affect 40-60 million people annually and are a growing public health concern worldwide. Despite efforts to provide medical and public health services to populations affected by complex emergencies, significant morbidity and mortality persist. Measles is a major communicable disease threat, but through vaccination of broader target age groups beyond the traditional immunization schedule, measles-related mortality has been significantly reduced during crises. Yet, a limited number of vaccine-preventable diseases continue to contribute disproportionately to morbidity and mortality in complex emergencies. The literature suggests that Streptococcus pneumoniae, Rotavirus, and Haemophilus influenzae type-b should be key targets for vaccination programs. Because of the significant contribution of these three pathogens to complex humanitarian emergencies in low and middle-income countries regardless of disaster type, geography, or population, their vaccines should be considered essential components of the standard emergency response effort. We discuss the barriers to vaccine distribution and provide evidence for strategies to improve distribution, including expanded target age-range and reduced dose schedules. Our review includes specific recommendations for the expanded use of these three vaccines in complex emergencies in low and middle-income countries as a way to guide future policy discussions. PMID:27527818

  10. Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization in Alzheimer's disease

    SciTech Connect

    Friedland, T.F.; Budinger, T.F.; Jaqust, W.J.; Yano, Y.; Huesman, R.H.; Knittel, B.; Koss, E.; Ober, B.A.

    1984-01-01

    The anatomical and chemical features of Alzheimer's disease (AD) are not distributed evenly throughout the brain. However, the nature of this focality has not been well established in vivo. Dynamic studies using the Donner 280-Crystal Positron Tomograph with (F-18)2-fluorodeoxyglucose were performed in 17 subjects meeting current research criteria for AD, and in 7 healthy age-matched control subjects. Glucose metabolic rates in the temporal-parietal cortex are 27% lower in AD than in controls. Ratios of activity density reveal consistently lower metabolic rates in temporal-parietal than frontal cortex in the AD group, while healthy aged subjects have equal metabolic rates in the two areas. Similar findings have been reported by other laboratories. A major finding is a striking lateral asymmetry of cortical metabolism in AD which does not favor either hemisphere. (The asymmetry is 13% in the AD group, 3% in controls, p<.005.) This has not been previously reported in AD. The consistency with which anterior-posterior metabolic differences are found in AD suggests that the focality of the metabolic changes may be used to develop a noninvasive diagnostic test for the disorder. The metabolic asymmetry in AD may be compared to the clinical and pathological asymmetry found in Creutzfeldt-Jakob disease, and may represent an additional link between AD and the subacute spongiform encephalopathies.

  11. Clinical utility of biomarkers in chronic kidney disease and chronic heart failure.

    PubMed

    Zachariah, Donah; Olechowski, Bartosz; Kalra, Paul R

    2013-09-01

    Biomarkers have an increasingly important clinical role in managing patients with heart failure as well as those with kidney disease, both common conditions with generally poor prognostic outcomes and huge impacts on healthcare economics. For patients with chronic heart failure, biomarkers have become centre place in streamlining diagnostic pathways as well as identifying those with worse prognosis. There is much interest in the role for biomarkers in identifying patients at risk of acute kidney injury, although a number of these currently remain as research tools or are in the early stages of evaluation in clinical practice. Patients with cardiorenal syndrome represent a particular challenge to the clinician, and recent studies have suggested a valuable clinical role for certain biomarkers in this setting, either on their own or in combination. This paper will focus on biomarkers with a current clinical role in patients with cardiorenal disease (natriuretic peptides and neutrophil gelatinase-associated lipocalin), although brief reference will be made to other biomarkers with potential future application.

  12. Radiocommunications for meteorological satellite systems

    NASA Technical Reports Server (NTRS)

    Walton, B. A.

    1975-01-01

    A general overview is presented of the spectrum utilization and frequency requirements of present and planned meteorological satellite programs. The sensors, and TIROS operational systems are discussed along with the Nimbus and Synchronous Meteorological Satellites. STORMSAT, SEASAT, and the Spacelab are briefly described.

  13. Evaluation of ventricular geometry and performance in congenital heart disease utilizing magnetic resonance imaging

    NASA Astrophysics Data System (ADS)

    Fogel, Mark A.

    1994-05-01

    We have recently embarked on a systematic evaluation of the regional and global mechanical processes of the systemic, morphologic right ventricle (RV) which is in either a single or dual chambered circulation as well as single left ventricles (LV). An MRI tagging technique which lays down 2 sets of parallel stripes perpendicular to each other on the myocardium as well as standard cine MRI were utilized. Finite strain analysis was applied to the grid lines to derive principle strains and the motion of the intersection points were tracked through systole to determine regional radial shortening and twist. Cine sequences were used to derive the various parameters of ventricular geometry and performance as well as visualizing flow profiles in the aorta. We noted a marked decrease in vol, EF, and CO in the Fontan group of patients when compared to other surgical subgroups. It is hypothesized that atrial stiffening by surgical placement of baffles may contribute to the observed changes in ventricular mechanics. Aortic flow profiles in the reconstructed aorta were noted to be heterogenous across the aortic diameter.

  14. On the definition and utilization of heritable variation among hosts in reproduction ratio R0 for infectious diseases.

    PubMed

    Anche, M T; de Jong, M C M; Bijma, P

    2014-10-01

    Infectious diseases have a major role in evolution by natural selection and pose a worldwide concern in livestock. Understanding quantitative genetics of infectious diseases, therefore, is essential both for understanding the consequences of natural selection and for designing artificial selection schemes in agriculture. The basic reproduction ratio, R0, is the key parameter determining risk and severity of infectious diseases. Genetic improvement for control of infectious diseases in host populations should therefore aim at reducing R0. This requires definitions of breeding value and heritable variation for R0, and understanding of mechanisms determining response to selection. This is challenging, as R0 is an emergent trait arising from interactions among individuals in the population. Here we show how to define breeding value and heritable variation for R0 for genetically heterogeneous host populations. Furthermore, we identify mechanisms determining utilization of heritable variation for R0. Using indirect genetic effects, next-generation matrices and a SIR (Susceptible, Infected and Recovered) model, we show that an individual's breeding value for R0 is a function of its own allele frequencies for susceptibility and infectivity and of population average susceptibility and infectivity. When interacting individuals are unrelated, selection for individual disease status captures heritable variation in susceptibility only, yielding limited response in R0. With related individuals, however, there is a secondary selection process, which also captures heritable variation in infectivity and additional variation in susceptibility, yielding substantially greater response. This shows that genetic variation in susceptibility represents an indirect genetic effect. As a consequence, response in R0 increased substantially when interacting individuals were genetically related.

  15. Cost reductions through earth resource satellites in developed countries

    NASA Technical Reports Server (NTRS)

    Schweickart, R. L.; Buffalano, A. C.

    1975-01-01

    Data from detailed studies on the possible economic impact of the use of remote sensing technology in industry and agriculture are presented and analyzed. The utility of satellite surveillance in reduction of crop production forecast error, recognition and monitoring of crop diseases and insect infestations, and range management is evaluated. Application of satellite maps to facilitate land resource decisions, mineral exploration, geological studies, and water resource inventories is considered, as is the usefulness of early storm warning in the reduction of property damage. The cost of remote sensing is compared to that of conventional methods whenever possible.

  16. Utility of Consumer Physical Activity Trackers as an Intervention Tool in Cardiovascular Disease Prevention and Treatment.

    PubMed

    Hickey, Amanda M; Freedson, Patty S

    2016-01-01

    Consumer activity trackers have grown in popularity over the last few years. These devices are typically worn on the hip or wrist and provide the user with information about physical activity measures such as steps taken, energy expenditure, and time spent in moderate to vigorous physical activity. The consumer may also use the computer interface (e.g. device websites, smartphone applications) to monitor and track achievement of PA goals and compete with other users. This review will describe some of the most popular consumer devices and discuss the user feedback tools. We will also present the limited evidence available about the accuracy of these devices and highlight how they have been used in cardiovascular disease management. We conclude with some recommendations for future research, focusing on how consumer devices might be used to assess effectiveness of various cardiovascular treatments.

  17. Susceptibility to ambient particulate matter on emergency care utilization for ischemic heart disease in Seoul, Korea.

    PubMed

    Sohn, Jungwoo; You, Seng Chan; Cho, Jaelim; Choi, Yoon Jung; Joung, Boyoung; Kim, Changsoo

    2016-10-01

    Many epidemiological studies have reported associations between ambient particulate matter (PM) and cardiovascular diseases. However, the effects associated with PM that promote cardiovascular events among susceptible populations who may respond differently than the general population to the same ambient air pollutants remain unclear. We conducted a time-series study with generalized additive models to assess the association between ambient PM10 and emergency department (ED) visits for ischemic heart disease (IHD) in Seoul, Republic of Korea from 2005 to 2009. The ED data and previous medical records within the 5 years of each IHD event to examine the effect of PM10 in a susceptible population were obtained from Health Insurance Review and Assessment Service. Overall, the adjusted relative risks (RRs) of ED visits for IHD were not statistically significant for PM10, but significant positive RRs were found for groups with hypertension (1.018; 95 % confidence interval [CI] 1.002-1.035) and those who are ≥80 years of age (1.019; 1.002-1.037) for same-day exposure and with diabetes (1.019; 1.002-1.037) for single-lag models. Subgroup analyses revealed gender differences in ED visits for IHD in hypertensive patients and those who are ≥80 years of age; positive correlations were found only in males with the lag models. Our study suggests that ambient PM10 is significantly associated with ED visits for IHD, especially in males with hypertension, diabetes mellitus, or who are aged ≥80 years. Identification of populations susceptible to air pollution is of paramount importance to establishing recommendations or guidelines for high-risk individuals. PMID:27380182

  18. Molecular diversity of cotton leaf curl Gezira virus isolates and their satellite DNAs associated with okra leaf curl disease in Burkina Faso.

    PubMed

    Tiendrébéogo, Fidèle; Lefeuvre, Pierre; Hoareau, Murielle; Villemot, Julie; Konaté, Gnissa; Traoré, Alfred S; Barro, Nicolas; Traoré, Valentin S; Reynaud, Bernard; Traoré, Oumar; Lett, Jean-Michel

    2010-02-23

    Okra leaf curl disease (OLCD) is a major constraint on okra (Abelmoschus esculentus) production and is widespread in Africa. Using a large number of samples representative of the major growing regions in Burkina Faso (BF), we show that the disease is associated with a monopartite begomovirus and satellite DNA complexes. Twenty-three complete genomic sequences of Cotton leaf curl Gezira virus (CLCuGV) isolates associated with OLCD, sharing 95 to 99% nucleotide identity, were cloned and sequenced. Six betasatellite and four alphasatellite (DNA-1) molecules were also characterized. The six isolates of betasatellite associated with CLCuGV isolates correspond to Cotton leaf curl Gezira betasatellite (CLCuGB) (88 to 98% nucleotide identity). One isolate of alphasatellite is a variant of Cotton leaf curl Gezira alphasatellite (CLCuGA) (89% nucleotide identity), whereas the three others isolates appear to correspond to a new species of alphasatellite (CLCuGA most similar sequence present 52 to 60% nucleotide identity), provisionally named Okra leaf curl Burkina Faso alphasatellite (OLCBFA). Recombination analysis of the viruses demonstrated the interspecies recombinant origin of all CLCuGV isolates, with parents being close to Hollyhock leaf crumple virus (AY036009) and Tomato leaf curl Diana virus (AM701765). Combined with the presence of satellites DNA, these results highlight the complexity of begomoviruses associated with OLCD.

  19. Utility of select plasma microRNAs for disease and cardiovascular risk assessment in patients with rheumatoid arthritis

    PubMed Central

    Vickers, Kasey C; Oeser, Annette M; Raggi, Paolo; Stein, C. Michael

    2015-01-01

    Objective MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression and serve as potential mediators and markers of disease. Recently, plasma miR-24-3p and miR-125a-5p concentrations were shown to be elevated in rheumatoid arthritis (RA) and useful for RA diagnosis. We assessed the utility of seven candidate plasma miRNAs, selected for biological relevance, for RA diagnosis and use as markers of disease activity and subclinical atherosclerosis in RA. Methods The cross-sectional study included 168 patients with RA and 91 control subjects, of similar age, race and sex. Plasma concentrations of miR-15a-5p, miR-24-3p, miR-26a-5p, miR-125a-5p, miR-146a-5p, miR-155-5p, and miR-223-3p were measured by quantitative PCR. Utility of plasma miRNA concentrations for RA diagnosis was assessed by area under the receiver operating characteristic curve (AUROC). Association between plasma miRNA concentrations and RA disease activity and coronary artery calcium score were assessed by Spearman correlations. Results Plasma concentrations of miR-15a-5p, 24-3p, miR-26a-5p, miR-125a-5p, miR-146a-5p, miR-155-5p, and miR-223-3p were significantly increased in patients with RA. miR-24-3p had the highest AUROC for diagnosis of RA (AUROC=0.725), including among rheumatoid factor negative patients (AUROC=0.772). Among all patients with RA, the combination of miR-24-3p, miR-26a-5p and miR-125a-5p improved the model modestly (AUROC=0.747). miR-155-5p was weakly inversely associated with swollen joint count (P=0.024), but no other miRNAs were associated with disease activity or coronary artery calcium score. Conclusion The combination of miR-24-3p, miR-26a-5p and miR-125a-5p had strongest diagnostic accuracy for RA. Candidate miRNAs had little or no association with RA disease activity or subclinical atherosclerosis. PMID:26233505

  20. Satellite Teleconferencing in the Caribbean.

    ERIC Educational Resources Information Center

    Sankar, Hollis C.

    1985-01-01

    Discusses the need for, and the development, use, and future trends of, the University of the West Indies Distance Teaching Experiment, which utilizes telephone and communications satellite technology teleconferencing to extend educational opportunities to the peoples of the Caribbean. (MBR)

  1. Mobile satellite ranging

    NASA Technical Reports Server (NTRS)

    Silverberg, E. C.

    1978-01-01

    A brief review of the constraints which have limited satellite ranging hardware and an outline of the steps which are underway to improve the status of the equipment in this area are given. In addition, some suggestions are presented for the utilization of newer instruments and for possible future research and development work in this area.

  2. Cortical glutaminase, beta-glucuronidase and glucose utilization in Alzheimer's disease.

    PubMed

    McGeer, E G; McGeer, P L; Akiyama, H; Harrop, R

    1989-11-01

    Large pyramidal neurons of rat and human neocortex stain immunohistochemically for phosphate-activated glutaminase (PAG). In a limited number of postmortem brains, we find large reductions in cortical PAG activity in Alzheimer's disease (AD). This finding is consistent with histological evidence that pyramidal neurons are affected in AD. The reductions are greater than those found in the same samples in choline acetyltransferase (ChAT) but the possible deleterious effects of coma and similar premortem factors on human PAG activity have yet to be assessed. The activity of beta-glucuronidase, a lysosomal enzyme which occurs in reactive astrocytes, is elevated in the same samples. Positron emission tomography (PET) studies, using 18F-fluorodeoxyglucose (FDG), have demonstrated significant deficiencies in glucose metabolism in the cortex in AD, with the parietal, temporal and some frontal areas being particularly affected. We found in serial scans of 13 AD cases, including one relatively young (44-46 year old) familial case, an exacerbation of the defect over time in most cases. We have found a negative correlation between the regional metabolic rates for glucose (LCMR(s] measured premortem and the beta-glucuronidase activities measured postmortem on a few AD cases that have come to autopsy. The correlations between LCMR(s) and PAG and ChAT activities tend to be positive. The results are consistent with previous suggestions that decreased LCMR(s) in AD reflect local neuronal loss and gliosis.

  3. The G-765C promoter polymorphism in cyclooxygenase-2 (PTGS2), aspirin utilization and cardiovascular disease risk: the Atherosclerosis Risk in Communities (ARIC) study

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cyclooxygenase-2 derived prostaglandins modulate cardiovascular disease risk. We sought to determine if the reduced function G-765C promoter polymorphism in PTGS2 was associated with incident coronary heart disease (CHD) or ischemic stroke risk, and if this was modified by aspirin utilization. Usin...

  4. Satellite RNAs and Satellite Viruses.

    PubMed

    Palukaitis, Peter

    2016-03-01

    Satellite RNAs and satellite viruses are extraviral components that can affect either the pathogenicity, the accumulation, or both of their associated viruses while themselves being dependent on the associated viruses as helper viruses for their infection. Most of these satellite RNAs are noncoding RNAs, and in many cases, have been shown to alter the interaction of their helper viruses with their hosts. In only a few cases have the functions of these satellite RNAs in such interactions been studied in detail. In particular, work on the satellite RNAs of Cucumber mosaic virus and Turnip crinkle virus have provided novel insights into RNAs functioning as noncoding RNAs. These effects are described and potential roles for satellite RNAs in the processes involved in symptom intensification or attenuation are discussed. In most cases, models describing these roles involve some aspect of RNA silencing or its suppression, either directly or indirectly involving the particular satellite RNA.

  5. X-Ray Magnetic Resonance Fusion to Internal Markers and Utility in Congenital Heart Disease Catheterization

    PubMed Central

    Dori, Yoav; Sarmiento, Marily; Glatz, Andrew C.; Gillespie, Matthew J.; Jones, Virginia M.; Harris, Matthew A.; Whitehead, Kevin K.; Fogel, Mark A.; Rome, Jonathan J.

    2012-01-01

    Background X-ray magnetic resonance fusion (XMRF) allows for use of 3D data during cardiac catheterization. However, to date, technical requirements have limited the use of this modality in clinical practice. We report on a new internal-marker XMRF method that we have developed and describe how we used XMRF during cardiac catheterization in congenital heart disease. Methods and Results XMRF was performed in a phantom and in 23 patients presenting for cardiac catheterization who also needed cardiac MRI for clinical reasons. The registration process was performed in <5 minutes per patient, with minimal radiation (0.004 to 0.024 mSv) and without contrast. Registration error was calculated in a phantom and in 8 patients using the maximum distance between angiographic and 3D model boundaries. In the phantom, the measured error in the anteroposterior projection had a mean of 1.15 mm (standard deviation, 0.73). The measured error in patients had a median of 2.15 mm (interquartile range, 1.65 to 2.56 mm). Internal markers included bones, airway, image artifact, calcifications, and the heart and vessel borders. The MRI data were used for road mapping in 17 of 23 (74%) cases and camera angle selection in 11 of 23 (48%) cases. Conclusions Internal marker–based registration can be performed quickly, with minimal radiation, without the need for contrast, and with clinically acceptable accuracy using commercially available software. We have also demonstrated several potential uses for XMRF in routine clinical practice. This modality has the potential to reduce radiation exposure and improve catheterization outcomes. PMID:21536785

  6. Identifying decreased diaphragmatic mobility and diaphragm thickening in interstitial lung disease: the utility of ultrasound imaging

    PubMed Central

    Santana, Pauliane Vieira; Prina, Elena; Albuquerque, André Luis Pereira; Carvalho, Carlos Roberto Ribeiro; Caruso, Pedro

    2016-01-01

    Objective: To investigate the applicability of ultrasound imaging of the diaphragm in interstitial lung disease (ILD). Methods: Using ultrasound, we compared ILD patients and healthy volunteers (controls) in terms of diaphragmatic mobility during quiet and deep breathing; diaphragm thickness at functional residual capacity (FRC) and at total lung capacity (TLC); and the thickening fraction (TF, proportional diaphragm thickening from FRC to TLC). We also evaluated correlations between diaphragmatic dysfunction and lung function variables. Results: Between the ILD patients (n = 40) and the controls (n = 16), mean diaphragmatic mobility was comparable during quiet breathing, although it was significantly lower in the patients during deep breathing (4.5 ± 1.7 cm vs. 7.6 ± 1.4 cm; p < 0.01). The patients showed greater diaphragm thickness at FRC (p = 0.05), although, due to lower diaphragm thickness at TLC, they also showed a lower TF (p < 0.01). The FVC as a percentage of the predicted value (FVC%) correlated with diaphragmatic mobility (r = 0.73; p < 0.01), and an FVC% cut-off value of < 60% presented high sensitivity (92%) and specificity (81%) for indentifying decreased diaphragmatic mobility. Conclusions: Using ultrasound, we were able to show that diaphragmatic mobility and the TF were lower in ILD patients than in healthy controls, despite the greater diaphragm thickness at FRC in the former. Diaphragmatic mobility correlated with ILD functional severity, and an FVC% cut-off value of < 60% was found to be highly accurate for indentifying diaphragmatic dysfunction on ultrasound. PMID:27167428

  7. Review: Utilization of antagonistic yeasts to manage postharvest fungal diseases of fruit.

    PubMed

    Liu, Jia; Sui, Yuan; Wisniewski, Michael; Droby, Samir; Liu, Yongsheng

    2013-10-15

    Significant losses in harvested fruit can be directly attributable to decay fungi. Some of these pathogenic fungi are also the source of mycotoxins that are harmful to humans. Biological control of postharvest decay of fruits, vegetables and grains using antagonistic yeasts has been explored as one of several promising alternatives to chemical fungicides, the use of which is facing increasingly more stringent regulation. Yeast species have been isolated over the past two decades from a variety of sources, including fruit surfaces, the phyllosphere, soil and sea water, and their potential as postharvest biocontrol agents has been investigated. Several mechanisms have been proposed as responsible for their antagonistic activity, including competition for nutrients and space, parasitism of the pathogen, secretion of antifungal compounds, induction of host resistance, biofilm formation, and most recently, the involvement of reactive oxygen species (ROS) in defense response. It has been recognized that a biocontrol system is composed of a three-way interaction between the host (commodity), the pathogen and the yeast, all of which are affected by environmental factors. Efficacy and consistent performance in controlling postharvest diseases are the hurdles that must be overcome if the use of yeast biocontrol agents and other alternatives are to be widely used commercially. Therefore, attempts have been made to combine alternative treatments in order improve their overall performance. The current review provides a brief overview of the topic of the use of yeasts as postharvest biocontrol agents and includes information on the sources from which yeast antagonists have been isolated, their mode of action, and abiotic stress resistance in yeast as it relates to biocontrol performance. Areas in need of future research are also highlighted.

  8. UTILIZATION OF COMBINATION ANTIHYPERTENSIVE THERAPY INITIATION IN OLDER AMERICANS WITHOUT PREVALENT CARDIOVASCULAR DISEASE

    PubMed Central

    LI, Xiaojuan; CAMELO CASTILLO, Wendy; STÜRMER, Til; PATE, Virginia; GRAY, Christine L.; SIMPSON, Ross J.; SETOGUCHI, Soko; HANSON, Laura C.; JONSSON FUNK, Michele

    2014-01-01

    OBJECTIVES To describe new users of antihypertensives and identify predictors of combination therapy initiation among older Americans. DESIGN Retrospective observational cohort study. SETTING Population-based study using U.S. Medicare fee-for-service healthcare claims (2007–2010). PARTICIPANTS 275,493 Medicare beneficiaries >65 years of age with no recent diagnoses, procedures or medications for cardiovascular disease who newly initiated antihypertensives (210,605 initiated monotherapy and 64,888 initiated combination therapy). MEASUREMENTS Multivariable Poisson regression assessed factors associated with initiation of combination versus monotherapy controlling for patient characteristics, prescriber characteristics and patient encounters with healthcare system. RESULTS Initiation of combination therapy increased from 21.9% in 2007 to 24.7% in 2010. The most frequently initiated combinations were angiotensin-converting-enzyme inhibitor/thiazide (29.7%) and angiotensin II receptor antagonists/thiazide (18.7%). Blacks (prevalence ratio 1.48, 95% confidence interval 1.45–1.51 compared with whites), patients seeing a generalist (1.10, 1.07–1.14), patients seeing more than one doctor (3.38, 3.33–3.44), or patients with no pharmacy claims in the last six months (1.34, 1.30–1.37 compared with three or more unique drug classes) were more likely to initiate combination therapy, while patients who had more outpatient visits in the last 12 months were less likely to initiate combination therapy (per five visits 0.82, 0.80–0.83). CONCLUSION Nearly one in four new users of antihypertensive over the age of 65 started treatment with combination therapy. Blacks, individuals living in the South, and patients who had fewer outpatient physician office visits were more likely to initiate combination therapy. Further research is needed to determine whether this approach to managing hypertension is being well-targeted to those patients who will require combination treatment

  9. Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease.

    PubMed

    Tse, Hoi Nam; Tseng, Cee Zhung Steven

    2014-01-01

    Chronic obstructive pulmonary disease (COPD) is a common and morbid disease characterized by high oxidative stress. Its pathogenesis is complex, and involves excessive oxidative stress (redox imbalance), protease/antiprotease imbalance, inflammation, apoptosis, and autoimmunity. Among these, oxidative stress has a pivotal role in the pathogenesis of COPD by initiating and mediating various redox-sensitive signal transduction pathways and gene expression. The protective physiological mechanisms of the redox balance in the human body, their role in the pathogenesis of COPD, and the clinical correlation between oxidative stress and COPD are reviewed in this paper. N-acetylcysteine (NAC) is a mucolytic agent with both antioxidant and anti-inflammatory properties. This paper also reviews the use of NAC in patients with COPD, especially the dose-dependent properties of NAC, eg, its effects on lung function and the exacerbation rate in patients with the disease. Earlier data from BRONCUS (the Bronchitis Randomized on NAC Cost-Utility Study) did not suggest that NAC was beneficial in patients with COPD, only indicating that it reduced exacerbation in an "inhaled steroid-naïve" subgroup. With regard to the dose-dependent properties of NAC, two recent randomized controlled Chinese trials suggested that high-dose NAC (1,200 mg daily) can reduce exacerbations in patients with COPD, especially in those with an earlier (moderately severe) stage of disease, and also in those who are at high risk of exacerbations. However, there was no significant effect on symptoms or quality of life in patients receiving NAC. Further studies are warranted to investigate the effect of NAC at higher doses in non-Chinese patients with COPD.

  10. Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders.

    PubMed

    Barral, Serena; Kurian, Manju A

    2016-01-01

    The study of neurological disorders often presents with significant challenges due to the inaccessibility of human neuronal cells for further investigation. Advances in cellular reprogramming techniques, have however provided a new source of human cells for laboratory-based research. Patient-derived induced pluripotent stem cells (iPSCs) can now be robustly differentiated into specific neural subtypes, including dopaminergic, inhibitory GABAergic, motorneurons and cortical neurons. These neurons can then be utilized for in vitro studies to elucidate molecular causes underpinning neurological disease. Although human iPSC-derived neuronal models are increasingly regarded as a useful tool in cell biology, there are a number of limitations, including the relatively early, fetal stage of differentiated cells and the mainly two dimensional, simple nature of the in vitro system. Furthermore, clonal variation is a well-described phenomenon in iPSC lines. In order to account for this, robust baseline data from multiple control lines is necessary to determine whether a particular gene defect leads to a specific cellular phenotype. Over the last few years patient-derived neural cells have proven very useful in addressing several mechanistic questions related to central nervous system diseases, including early-onset neurological disorders of childhood. Many studies report the clinical utility of human-derived neural cells for testing known drugs with repurposing potential, novel compounds and gene therapies, which then can be translated to clinical reality. iPSCs derived neural cells, therefore provide great promise and potential to gain insight into, and treat early-onset neurological disorders. PMID:27656126

  11. Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders

    PubMed Central

    Barral, Serena; Kurian, Manju A.

    2016-01-01

    The study of neurological disorders often presents with significant challenges due to the inaccessibility of human neuronal cells for further investigation. Advances in cellular reprogramming techniques, have however provided a new source of human cells for laboratory-based research. Patient-derived induced pluripotent stem cells (iPSCs) can now be robustly differentiated into specific neural subtypes, including dopaminergic, inhibitory GABAergic, motorneurons and cortical neurons. These neurons can then be utilized for in vitro studies to elucidate molecular causes underpinning neurological disease. Although human iPSC-derived neuronal models are increasingly regarded as a useful tool in cell biology, there are a number of limitations, including the relatively early, fetal stage of differentiated cells and the mainly two dimensional, simple nature of the in vitro system. Furthermore, clonal variation is a well-described phenomenon in iPSC lines. In order to account for this, robust baseline data from multiple control lines is necessary to determine whether a particular gene defect leads to a specific cellular phenotype. Over the last few years patient-derived neural cells have proven very useful in addressing several mechanistic questions related to central nervous system diseases, including early-onset neurological disorders of childhood. Many studies report the clinical utility of human-derived neural cells for testing known drugs with repurposing potential, novel compounds and gene therapies, which then can be translated to clinical reality. iPSCs derived neural cells, therefore provide great promise and potential to gain insight into, and treat early-onset neurological disorders. PMID:27656126

  12. Satellite communication for public services

    NASA Technical Reports Server (NTRS)

    Cooper, R. S.; Redisch, W. N.

    1977-01-01

    Public service programs using NASA's ATS-6 and CTS satellites are discussed. Examples include the ATS-6 Health and Education Telecommunications experimental program and the use of CTS to enable students in one university to take courses presented at another distant university. Possible applications of satellite communication systems to several areas of public service are described, and economic and political obstacles hindering the implementation of these programs are considered. It is suggested that a federally sponsored program demonstrating the utility of satellites accomodating a large number of small terminals is needed to encourage commercial satellite operations.

  13. Effects of the West Africa Ebola Virus Disease on Health-Care Utilization – A Systematic Review

    PubMed Central

    Brolin Ribacke, Kim J.; Saulnier, Dell D.; Eriksson, Anneli; von Schreeb, Johan

    2016-01-01

    Significant efforts were invested in halting the recent Ebola virus disease outbreak in West Africa. Now, studies are emerging on the magnitude of the indirect health effects of the outbreak in the affected countries, and the aim of this study is to systematically assess the results of these publications. The methodology for this review adhered to the Prisma guidelines for systematic reviews. A total of 3354 articles were identified for screening, and while 117 articles were read in full, 22 studies were included in the final review. Utilization of maternal health services decreased during the outbreak. The number of cesarean sections and facility-based deliveries declined and followed a similar pattern in Guinea, Liberia, and Sierra Leone. A change in the utilization of antenatal and postnatal care and family planning services was also seen, as well as a drop in utilization of children’s health services, especially in terms of vaccination coverage. In addition, the uptake of HIV/AIDS and malaria services, general hospital admissions, and major surgeries decreased as well. Interestingly, it was the uptake of health service provision by the population that decreased, rather than the volume of health service provision. Estimates from the various studies suggest that non-Ebola morbidity and mortality have increased after the onset of the outbreak in Sierra Leone, Guinea, and Liberia. Reproductive, maternal, and child health services were especially affected, and the decrease in facility deliveries, cesarean sections, and volume of antenatal and postnatal care visits might have significant adverse effects on maternal and newborn health. The impact of Ebola stretches far beyond Ebola cases and deaths. This review indicates that indirect health service effects are substantial and both short and long term, and highlights the importance of support to maintain routine health service delivery and the maintenance of vaccination programs as well as preventative and curative

  14. Awareness, utilization, and determinants of using oral diseases prevention methods among Saudi adults – a clinic-based pilot study

    PubMed Central

    Al-Ansari, Asim

    2016-01-01

    Objectives The present study was conducted to assess the level of awareness and utilization of methods to prevent oral diseases among a group of adult Saudis. Methodology An anonymous, self-administered questionnaire was distributed to patients visiting the clinics of the College of Dentistry, University of Dammam in 2015. The questionnaire assessed the background of the respondents, their dental history, awareness and use of a number of methods available to prevent oral diseases, sources of information about these methods and barriers against their use. Regression analysis was used to assess the factors affecting the use of these practices. Results Brushing was reported to be used by about 60% of respondents whereas fluoride and sealant were less prevalent (≤30%). Dentist was the most frequently reported source of information about preventive methods (60%) and about 40% cited cost and time as the main reasons why they did not use these preventive methods. Awareness and age were associated with using a greater number of the various preventive methods (odds regression coefficient ratio= 0.27 and 0.04). Conclusions Use of preventive methods is not prevalent among Saudi adults and it can be improved by more intensive efforts to increase the awareness of these methods, primarily through dentists. PMID:27004060

  15. Prognostic Utility of Calcium Scoring as an Adjunct to Stress Myocardial Perfusion Scintigraphy in End-Stage Renal Disease

    PubMed Central

    Moody, William E.; Lin, Erica L.S.; Stoodley, Matthew; McNulty, David; Thomson, Louise E.; Berman, Daniel S.; Edwards, Nicola C.; Holloway, Benjamin; Ferro, Charles J.; Townend, Jonathan N.; Steeds, Richard P.

    2016-01-01

    Coronary artery calcium score (CACS) is a strong predictor of adverse cardiovascular events in the general population. Recent data confirm the prognostic utility of single-photon emission computed tomographic (SPECT) imaging in end-stage renal disease, but whether performing CACS as part of hybrid imaging improves risk prediction in this population is unclear. Consecutive patients (n = 284) were identified after referral to a university hospital for cardiovascular risk stratification in assessment for renal transplantation. Participants underwent technetium-99m SPECT imaging after exercise or standard adenosine stress in those unable to achieve 85% maximal heart rate; multislice CACS was also performed (Siemens Symbia T16, Siemens, Erlangen, Germany). Subjects with known coronary artery disease (n = 88) and those who underwent early revascularization (n = 2) were excluded. The primary outcome was a composite of death or first myocardial infarction. An abnormal SPECT perfusion result was seen in 22% (43 of 194) of subjects, whereas 45% (87 of 194) had at least moderate CACS (>100 U). The frequency of abnormal perfusion (summed stress score ≥4) increased with increasing CACS severity (p = 0.049). There were a total of 15 events (8 deaths, and 7 myocardial infarctions) after a median duration of 18 months (maximum follow-up 3.4 years). Univariate analysis showed diabetes mellitus (Hazard ratio [HR] 3.30, 95% CI 1.14 to 9.54; p = 0.028), abnormal perfusion on SPECT (HR 5.32, 95% CI 1.84 to 15.35; p = 0.002), and moderate-to-severe CACS (HR 3.55, 95% CI 1.11 to 11.35; p = 0.032) were all associated with the primary outcome. In a multivariate model, abnormal perfusion on SPECT (HR 4.18, 95% CI 1.43 to 12.27; p = 0.009), but not moderate-to-severe CACS (HR 2.50, 95% CI 0.76 to 8.20; p = 0.130), independently predicted all-cause death or myocardial infarction. The prognostic value of CACS was not incremental to clinical and SPECT perfusion data (global chi

  16. Prognostic Utility of Calcium Scoring as an Adjunct to Stress Myocardial Perfusion Scintigraphy in End-Stage Renal Disease.

    PubMed

    Moody, William E; Lin, Erica L S; Stoodley, Matthew; McNulty, David; Thomson, Louise E; Berman, Daniel S; Edwards, Nicola C; Holloway, Benjamin; Ferro, Charles J; Townend, Jonathan N; Steeds, Richard P

    2016-05-01

    Coronary artery calcium score (CACS) is a strong predictor of adverse cardiovascular events in the general population. Recent data confirm the prognostic utility of single-photon emission computed tomographic (SPECT) imaging in end-stage renal disease, but whether performing CACS as part of hybrid imaging improves risk prediction in this population is unclear. Consecutive patients (n = 284) were identified after referral to a university hospital for cardiovascular risk stratification in assessment for renal transplantation. Participants underwent technetium-99m SPECT imaging after exercise or standard adenosine stress in those unable to achieve 85% maximal heart rate; multislice CACS was also performed (Siemens Symbia T16, Siemens, Erlangen, Germany). Subjects with known coronary artery disease (n = 88) and those who underwent early revascularization (n = 2) were excluded. The primary outcome was a composite of death or first myocardial infarction. An abnormal SPECT perfusion result was seen in 22% (43 of 194) of subjects, whereas 45% (87 of 194) had at least moderate CACS (>100 U). The frequency of abnormal perfusion (summed stress score ≥4) increased with increasing CACS severity (p = 0.049). There were a total of 15 events (8 deaths, and 7 myocardial infarctions) after a median duration of 18 months (maximum follow-up 3.4 years). Univariate analysis showed diabetes mellitus (Hazard ratio [HR] 3.30, 95% CI 1.14 to 9.54; p = 0.028), abnormal perfusion on SPECT (HR 5.32, 95% CI 1.84 to 15.35; p = 0.002), and moderate-to-severe CACS (HR 3.55, 95% CI 1.11 to 11.35; p = 0.032) were all associated with the primary outcome. In a multivariate model, abnormal perfusion on SPECT (HR 4.18, 95% CI 1.43 to 12.27; p = 0.009), but not moderate-to-severe CACS (HR 2.50, 95% CI 0.76 to 8.20; p = 0.130), independently predicted all-cause death or myocardial infarction. The prognostic value of CACS was not incremental to clinical and SPECT perfusion data (global chi-square change

  17. Utilizing satellite precipitation estimates for streamflow forecasting via adjustment of mean field bias in precipitation data and assimilation of streamflow observations

    NASA Astrophysics Data System (ADS)

    Lee, Haksu; Zhang, Yu; Seo, Dong-Jun; Xie, Pingping

    2015-10-01

    This study explores mitigating bias in satellite quantitative precipitation estimates (SQPE) and improving hydrologic predictions at ungauged locations via adjustment of the mean field bias (MFB) in SQPE and data assimilation (DA) of streamflow observations in a distributed hydrologic model. In this study, a variational procedure is used to adjust MFB in Climate Prediction Center MORPHing (CMORPH) SQPE and assimilate streamflow observations at the outlet of Elk River Basin in Missouri into the distributed Sacramento Soil Moisture Accounting (SAC-SMA) and kinematic wave routing models. The benefits of assimilation are assessed by comparing the streamflow predictions with or without DA at both the outlet and an upstream location, and by comparing the soil moisture grids forced by CMORPH SQPE against those forced by higher-quality multisensor quantitative precipitation estimates (MQPE) from National Weather Service. Special attention is given to the dependence of the efficacy of DA on the quality and latency of the SQPE, and the impact of dynamic correction of MFB in the SQPE via DA. The results show that adjusting MFB in CMORPH SQPE in addition to assimilating outlet flow reduces 66% of the bias in the CMORPH SQPE analysis and the RMSE of 12-h streamflow predictions by 81% at the outlet and 34-62% at interior locations of the catchment. Compared to applying a temporally invariant MFB for the entire storm, the DA-based, dynamic MFB correction reduces the RMSE of 6-h streamflow prediction by 63% at the outlet and 39-69% at interior locations. It is also shown that the accuracy of streamflow prediction deteriorates if the delineation of the precipitation area by CMORPH SQPE is significantly different, as measured by the Hausdorff distance, from that by MQPE. When compared with adjusting MFB in the CMORPH SQPE over the entire assimilation window, adjusting the MFB for all but the latest 18 h (i.e., the latency of CMORPH SQPE) within the assimilation window reduces the

  18. Association Between Satellite-based Estimates of Long-term PM2.5 Exposure and Coronary Artery Disease

    EPA Science Inventory

    Background: Epidemiological studies have identified associations between long-term PM2.5 exposure and cardiovascular events, though most have relied on concentrations from central-site air quality monitors. Methods: We utilized a cohort of 5679 patients who had undergone cardiac ...

  19. Japan's efforts to promote global health using satellite remote sensing data from the Japan Aerospace Exploration Agency for prediction of infectious diseases and air quality.

    PubMed

    Igarashi, Tamotsu; Kuze, Akihiko; Sobue, Shinichi; Yamamoto, Aya; Yamamoto, Kazuhide; Oyoshi, Kei; Imaoka, Keiji; Fukuda, Toru

    2014-12-01

    In this paper we review the status of new applications research of the Japanese Aerospace Exploration Agency (JAXA) for global health promotion using information derived from Earth observation data by satellites in cooperation with inter-disciplinary collaborators. Current research effort at JAXA to promote global public health is focused primarily on the use of remote sensing to address two themes: (i) prediction models for malaria and cholera in Kenya, Africa; and (ii) air quality assessment of small, particulate matter (PM2.5), nitrogen dioxide (NO2) and ozone (O3). Respiratory and cardivascular diseases constitute cross-boundary public health risk issues on a global scale. The authors report here on results of current of a collaborative research to call attention to the need to take preventive measures against threats to public health using newly arising remote sensing information from space.

  20. Japan's efforts to promote global health using satellite remote sensing data from the Japan Aerospace Exploration Agency for prediction of infectious diseases and air quality.

    PubMed

    Igarashi, Tamotsu; Kuze, Akihiko; Sobue, Shinichi; Yamamoto, Aya; Yamamoto, Kazuhide; Oyoshi, Kei; Imaoka, Keiji; Fukuda, Toru

    2014-01-01

    In this paper we review the status of new applications research of the Japanese Aerospace Exploration Agency (JAXA) for global health promotion using information derived from Earth observation data by satellites in cooperation with inter-disciplinary collaborators. Current research effort at JAXA to promote global public health is focused primarily on the use of remote sensing to address two themes: (i) prediction models for malaria and cholera in Kenya, Africa; and (ii) air quality assessment of small, particulate matter (PM2.5), nitrogen dioxide (NO2) and ozone (O3). Respiratory and cardivascular diseases constitute cross-boundary public health risk issues on a global scale. The authors report here on results of current of a collaborative research to call attention to the need to take preventive measures against threats to public health using newly arising remote sensing information from space. PMID:25599641

  1. Meteorological satellites

    NASA Technical Reports Server (NTRS)

    Allison, L. J. (Editor); Schnapf, A.; Diesen, B. C., III; Martin, P. S.; Schwalb, A.; Bandeen, W. R.

    1980-01-01

    An overview is presented of the meteorological satellite programs that have been evolving from 1958 to the present, and plans for the future meteorological and environmental satellite systems that are scheduled to be placed into service in the early 1980's are reviewed. The development of the TIROS family of weather satellites, including TIROS, ESSA, ITOS/NOAA, and the present TIROS-N (the third generation operational system) is summarized. The contribution of the Nimbus and ATS technology satellites to the development of the operational-orbiting and geostationary satellites is discussed. Included are descriptions of both the TIROS-N and the DMSP payloads currently under development to assure a continued and orderly growth of these systems into the 1980's.

  2. Utility of Ultrasound, Transaminases, and Visual Inspection to Assess Nonalcoholic Fatty Liver Disease in Bariatric Surgery Patients

    PubMed Central

    Petrick, Anthony; Wood, G. Craig; Still, Christopher D.; Strodel, William E.; Gabrielsen, John; Rolston, David; Chu, Xin; Argyropoulos, George; Ibele, Anna; Gerhard, Glenn S.

    2016-01-01

    Background Nonalcoholic fatty liver disease (NAFLD) is common in adults with extreme obesity and can impact long-term health and survival. Liver biopsy is the only accurate test for diagnosis and staging, but is invasive and costly. Non-invasive testing offers an attractive alternate, but the overall accuracy remains a significant issue. This study was conducted to determine the accuracy and clinical utility of preoperative ultrasound and liver transaminase levels, as well as intra-operative hepatic visual inspection, for assessing presence of NAFLD as confirmed by hepatic histology. Methods Data was collected prospectively from 580 morbidly obese adult patients who underwent Roux-en-Y gastric bypass surgery with intraoperative wedge biopsy between January 2004 and February 2009. Complete data for ultrasound, ALT and AST levels, and documented visual inspection was available for 513 patients. Results The prevalence of NAFLD was 69 % and that of NASH was 32 %. The individual non-invasive clinical assessments demonstrated low sensitivity, specificity, and accuracy for detecting the presence of steatosis, steatohepatitis, or fibrosis. The combination of normal or abnormal results for all tests improved predictive utility. Abnormal tests with all three assessments had a sensitivity of 95–98 % and a specificity of 28–48 % for major histologic findings in NAFLD/NASH. Normal tests with all three assessments had a sensitivity of 12–22 % and a specificity of 89–97 % for major histologic findings in NAFLD/NASH. Conclusions Although individual clinical tests for NAFLD have limited accuracy, the use of combined clinical tests may prove useful. PMID:26003548

  3. Health care utilization, costs, and the burden of disease related to eosinophilic esophagitis in the United States

    PubMed Central

    Jensen, Elizabeth T.; Kappelman, Michael D.; Martin, Christopher F.; Dellon, Evan S.

    2015-01-01

    Objectives Eosinophilic esophagitis (EoE) has rapidly become a major cause of upper GI morbidity, but health care costs related to EoE have not been described. This study aimed to estimate EoE-related health care costs and utilization in the United States. Methods We performed a study of health care utilization of EoE cases compared to age- and sex-matched controls using administrative claims data, representative of the commercially insured population in the U.S. Cases of EoE were identified using a previously validated definition. We assessed inpatient, outpatient, emergency department, outpatient prescription, and endoscopy-related costs for patients with EoE, and estimated total costs related to EoE extrapolated to the U.S. population. Results We identified 8,135 cases of EoE and 32,540 controls. The median total annual cost per EoE case was $3,304 compared to $1,001 for controls (p<0.001). For EoE, median costs included $2,508/year for outpatient visits, $157 for endoscopies, and $325 for pharmacy claims, compared to $699, $0, and $76 for controls (p<0.001 for all). The overall median costs associated with EoE were $2,302/year/patient. Total costs in the U.S. ranged from $503 million to $1.36 billion/year, depending on the prevalence estimate, with costs attributable to EoE ranging from $350-$947 million/year. Conclusions Patients with EoE have an estimated annual health care cost of as much as $1.4 billion in the U.S. This represents a remarkable burden of disease for an entity that was essentially unknown two decades ago. These cost data can be used by policy makers to guide resource allocation. PMID:25267327

  4. Health State Utility Value in Chronic Obstructive Pulmonary Disease (COPD); The Challenge of Heterogeneity: A Systematic Review and Meta-Analysis.

    PubMed

    Moayeri, Foruhar; Hsueh, Ya-Seng Arthur; Clarke, Philip; Hua, Xinyang; Dunt, David

    2016-06-01

    Chronic obstructive pulmonary disease (COPD) has a considerable impact on quality of life and well-being of patients. Health state utility value (HSUV) is a recognized measure for health economic appraisals and is extensively used as an indicator for decision-making studies. This study is a systematic review of literature aimed to estimate mean utility value in COPD using meta-analysis and explore degree of heterogeneity in the utility values across a variety of clinical and study characteristic. The literature review covers studies that used EQ-5D to estimate utility value for patient level research in COPD. Studies that reported utility values elicited by EQ-5D in COPD patients were selected for random-effect meta-analysis addressing inter-study heterogeneity and subgroup analyses. Thirty-two studies were included in the general utility meta-analysis. The estimated general utility value was 0.673 (95% CI 0.653 to 0.693). Meta-analyses of COPD stages utility values showed influence of airway obstruction on utility value. The utility values ranged from 0.820 (95% CI 0.767 to 0.872) for stage I to 0.624 (95% CI 0.571 to 0.677) for stage IV. There was substantial heterogeneity in utility values: I(2) = 97.7%. A more accurate measurement of utility values in COPD is needed to refine valid and generalizable scores of HSUV. Given the limited success of the factors studied to reduce heterogeneity, an approach needs to be developed how best to use mean utility values for COPD in health economic evaluation.

  5. Potential utility of three-dimensional temperature and salinity fields estimated from satellite altimetry and Argo data for improving mesoscale reproducibility in regional ocean modeling

    NASA Astrophysics Data System (ADS)

    Kanki, R.; Uchiyama, Y.; Miyazaki, D.; Takano, A.; Miyazawa, Y.; Yamazaki, H.

    2014-12-01

    Mesoscale oceanic structure and variability are required to be reproduced as accurately as possible in realistic regional ocean modeling. Uchiyama et al. (2012) demonstrated with a submesoscale eddy-resolving JCOPE2-ROMS downscaling oceanic modeling system that the mesoscale reproducibility of the Kuroshio meandering along Japan is significantly improved by introducing a simple restoration to data which we call "TS nudging" (a.k.a. robust diagnosis) where the prognostic temperature and salinity fields are weakly nudged four-dimensionally towards the assimilative JCOPE2 reanalysis (Miyazawa et al., 2009). However, there is not always a reliable reanalysis for oceanic downscaling in an arbitrary region and at an arbitrary time, and therefore alternative dataset should be prepared. Takano et al. (2009) proposed an empirical method to estimate mesoscale 3-D thermal structure from the near real-time AVISO altimetry data along with the ARGO float data based on the two-layer model of Goni et al. (1996). In the present study, we consider the TS data derived from this method as a candidate. We thus conduct a synoptic forward modeling of the Kuroshio using the JCOPE2-ROMS downscaling system to explore potential utility of this empirical TS dataset (hereinafter TUM-TS) by carrying out two runs with the T-S nudging towards 1) the JCOPE2-TS and 2) TUM-TS fields. An example of the comparison between the two ROMS test runs is shown in the attached figure showing the annually averaged surface EKE. Both of TUM-TS and JCOPE2-TS are found to help reproducing the mesoscale variance of the Koroshio and its extension as well as its mean paths, surface KE and EKE reasonably well. Therefore, the AVISO-ARGO derived empirical 3-D TS estimation is potentially exploitable for the dataset to conduct the T-S nudging to reproduce mesoscale oceanic structure.

  6. Calibration and Evaluation of a Flood Forecasting System: Utility of Numerical Weather Prediction Model, Data Assimilation and Satellite-based Rainfall

    NASA Astrophysics Data System (ADS)

    Yucel, Ismail; Onen, Alper; Yilmaz, Koray; Gochis, David

    2015-04-01

    A fully-distributed, multi-physics, multi-scale hydrologic and hydraulic modeling system, WRF-Hydro, is used to assess the potential for skillful flood forecasting based on precipitation inputs derived from the Weather Research and Forecasting (WRF) model and the EUMETSAT Multi-sensor Precipitation Estimates (MPEs). Similar to past studies it was found that WRF model precipitation forecast errors related to model initial conditions are reduced when the three dimensional atmospheric data assimilation (3DVAR) scheme in the WRF model simulations is used. The study then undertook a comparative evaluation of the impact of MPE versus WRF precipitation estimates, both with and without data assimilation, in driving WRF-Hydro simulated streamflow. Several flood events that occurred in the Black Sea region were used for testing and evaluation. Following model calibration, the WRF-Hydro system was capable of skillfully reproducing observed flood hydrographs in terms of the volume of the runoff produced and the overall shape of the hydrograph. Streamflow simulation skill was significantly improved for those WRF model simulations where storm precipitation was accurately depicted with respect to timing, location and amount. Accurate streamflow simulations were more evident in WRF model simulations where the 3DVAR scheme was used compared to when it was not used. Because of substantial dry bias feature of MPE, streamflow derived using this precipitation product is in general very poor. Overall, root mean squared errors for runoff were reduced by 22.2% when hydrological model calibration is performed with WRF precipitation. Errors were reduced by 36.9% (above uncalibrated model performance) when both WRF model data assimilation and hydrological model calibration was utilized. Our results also indicated that when assimilated precipitation and model calibration is performed jointly, the calibrated parameters at the gauged sites could be transferred to ungauged neighboring basins

  7. On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases

    PubMed Central

    Odagiri, Hayato; Baba, Toru; Nishio, Yoshiyuki; Iizuka, Osamu; Matsuda, Minoru; Inoue, Kentaro; Kikuchi, Akio; Hasegawa, Takafumi; Aoki, Masashi; Takeda, Atsushi; Taki, Yasuyuki; Mori, Etsuro

    2016-01-01

    Background Abnormal cardiac uptake of 123I-metaiodobenzylguanidine (123I-MIBG) is a diagnostic marker of Lewy body diseases (LBDs), e.g., Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Planar imaging is generally used to assess cardiac sympathetic dysfunction in 123I-MIBG scintigraphy; however, its clinical utility requires further improvement. We hypothesized that the co-registration of single-photon emission tomography (SPECT) and computed tomography (CT) images would improve the diagnostic accuracy of 123I-MIBG cardiac scintigraphy for LBDs. This study sought to evaluate the effects of SPECT/CT imaging on 123I-MIBG cardiac scintigraphy for diagnosing LBDs. Methods We retrospectively investigated data of 54 patients (consecutive 18 patients in each PD, DLB, and idiopathic normal pressure hydrocephalus [iNPH] groups) who underwent 123I-MIBG cardiac scintigraphy (planar and SPECT/CT) because of suspected LBDs at the Tohoku University hospital from June 2012 to June 2015. We compared the diagnostic accuracies of the conventional planar 123I-MIBG method and SPECT/CT methods (manual and semi-automatic). Results In the conventional planar analysis, 123I-MIBG uptake decreased only in the DLB group compared with the iNPH group. In contrast, the SPECT/CT analysis revealed significantly lower 123I-MIBG uptake in both the PD and DLB groups compared with the iNPH group. Furthermore, a receiver operating characteristic analysis revealed that both the manual and semi-automatic SPECT/CT methods were superior to the conventional planar method in differentiating the 3 disorders. Conclusions SPECT/CT 123I-MIBG cardiac scintigraphy can detect mild cardiac sympathetic dysfunction in LDBs. Our results suggest that the SPECT/CT technique improves diagnostic accuracy for LBDs. PMID:27055151

  8. Using satellite data to study the relationship between rainfall and diarrheal diseases in a Southwestern Amazon basin.

    PubMed

    Fonseca, Paula Andrea Morelli; Hacon, Sandra de Souza; Reis, Vera Lúcia; Costa, Duarte; Brown, Irving Foster

    2016-03-01

    The North region is the second region in Brazil with the highest incidence rate of diarrheal diseases in children under 5 years old. The aim of this study was to investigate the relationship between rainfall and water level during the rainy season principally with the incidence rate of this disease in a southwestern Amazon basin. Rainfall estimates and the water level were correlated and both of them were correlated with the diarrheal incidence rate. For the Alto Acre region, 2 to 3 days' time-lag is the best interval to observe the impact of the rainfall in the water level (R = 0.35). In the Lower Acre region this time-lag increased (4 days) with a reduction in the correlation value was found. The correlation between rainfall and diarrheal disease was better in the Lower Acre region (Acrelândia, R = 0.7) and rainfall upstream of the city. Between water level and diarrheal disease, the best results were found for the Brasiléia gauging station (Brasiléia, R = 0.3; Epitaciolândia, R = 0.5). This study's results may support planning and financial resources allocation to prioritize actions for local Civil Defense and health care services before, during and after the rainy season.

  9. Calibration and evaluation of a flood forecasting system: Utility of numerical weather prediction model, data assimilation and satellite-based rainfall

    NASA Astrophysics Data System (ADS)

    Yucel, I.; Onen, A.; Yilmaz, K. K.; Gochis, D. J.

    2015-04-01

    22.2% when hydrological model calibration is performed with WRF precipitation. Errors were reduced by 36.9% (above uncalibrated model performance) when both WRF model data assimilation and hydrological model calibration was utilized. Our results also indicated that when assimilated precipitation and model calibration is performed jointly, the calibrated parameters at the gauged sites could be transferred to ungauged neighboring basins where WRF-Hydro reduced mean root mean squared error from 8.31 m3/s to 6.51 m3/s.

  10. Microimaging studies of myocardial substrate utilization and perfusion in two models of non-coronary heart disease

    SciTech Connect

    Som, P.; Oster, Z.H.; Knapp, F.F. Jr.

    1987-01-01

    We have studied two animal models of non-coronary heart disease. The salt-sensitive Dahl strain hypertensive rats and their genetically matched normotensive controls and the cardiomyopathic BIO 53.58 (CM) strain Syrian hamsters with age and sex-matched RB strain controls. The CM strain hamster seems to be a very good model of human congestive cardiomyopathy and the Dahl strain hypertensive rats have also been found to be good models for studying the effects of hypertension on the myocardium. In our studies we compared the utilization of various metabolic substrates, viz., fatty acids, glucose analogs, and the early distribution of /sup 201/Tl, as an indicator of myocardial flow. The routine studies involving dissection of animals for assaying the radioactivity following the injection of radiopharmaceuticals is not suitable for assessing regional changes in metabolism and flow. The use of quantitative autoradiographic microimaging (ARG) enables the visualization of discrete regional as well as global changes from normal and to quantitate them. This paper describes the methodology and results of these investigations. 14 refs., 5 figs.

  11. Utility of Iron Staining in Identifying the Cause of Renal Allograft Dysfunction in Patients with Sickle Cell Disease.

    PubMed

    Wang, Yingchun; Doshi, Mona; Khan, Salman; Li, Wei; Zhang, Ping L

    2015-01-01

    Sickle cell nephropathy (SCN) is associated with iron/heme deposition in proximal renal tubules and related acute tubular injury (ATI). Here we report the utility of iron staining in differentiating causes of renal allograft dysfunction in patients with a history of sickle cell disease. Case 1: the patient developed acute allograft dysfunction two years after renal transplant. Her renal biopsy showed ATI, supported by patchy loss of brush border and positive staining of kidney injury molecule-1 in proximal tubular epithelial cells, where diffuse increase in iron staining (2+) was present. This indicated that ATI likely resulted from iron/heme toxicity to proximal tubules. Electron microscope confirmed aggregated sickle RBCs in glomeruli, indicating a recurrent SCN. Case 2: four years after renal transplant, the patient developed acute allograft dysfunction and became positive for serum donor-specific antibody. His renal biopsy revealed thrombotic microangiopathy (TMA) and diffuse positive C4d stain in peritubular capillaries. Iron staining was negative in the renal tubules, implying that TMA was likely associated with acute antibody-mediated rejection (AAMR, type 2) rather than recurrent SCN. These case reports imply that iron staining is an inexpensive but effective method in distinguishing SCN-associated renal injury in allograft kidney from other etiologies. PMID:26697257

  12. Satellite based remote sensing technique as a tool for real time monitoring of leaf retention in natural rubber plantations affected by abnormal leaf fall disease

    NASA Astrophysics Data System (ADS)

    Pradeep, B.; Meti, S.; James, J.

    2014-11-01

    Most parts of the traditional natural rubber growing regions of India, extending from Kanyakumari district of Tamil Nadu in the South to Kasaragod district of Kerala in the North received excess and prolonged rains during 2013. This led to severe incidence of Abnormal Leaf Fall (ALF) disease caused by the fungus, Phytophthora sp. The present study demonstrated the first time use of satellite remote sensing technique to monitor ALF disease by estimating Leaf Area Index (LAI) in natural rubber holdings in near real time. Leaf retention was monitored in between April and December 2012 and 2013 by estimating LAI using MODIS 15A2 product covering rubber holdings spread across all districts in the traditional rubber growing region of the country that was mapped using Resourcesat LISS III 2012 and 2013 data. It was found that as the monsoon advanced, LAI decreased substantially in both years, but the reduction was much more substantial and prolonged in many districts during 2013 than 2012 reflecting increased leaf fall due to ALF disease in 2013. The decline was more pronounced in central and northern Kerala than in the South. Kanyakumari district of Tamil Nadu is generally known to be free from ALF disease, but there was considerable leaf loss due to ALF in June 2012 and June and July 2013 even as the monsoon was unusually severe in 2013. Weighted mean LAI during for the entire period of April to December was estimated as a weighted average of LAI and per cent of total area under rubber in each district in the study area for the two years. This was markedly less in 2013 than 2012. The implications of poor leaf retention for biomass production (net primary productivity), carbon sequestration and rubber yield are discussed.

  13. Satellite myths

    NASA Astrophysics Data System (ADS)

    Easton, Roger L.; Hall, David

    2008-01-01

    Richard Corfield's article “Sputnik's legacy” (October 2007 pp23-27) states that the satellite on board the US Vanguard rocket, which exploded during launch on 6 December 1957 two months after Sputnik's successful take-off, was “a hastily put together contraption of wires and circuitry designed only to send a radio signal back to Earth”. In fact, the Vanguard satellite was developed over a period of several years and put together carefully using the best techniques and equipment available at the time - such as transistors from Bell Laboratories/Western Electric. The satellite contained not one but two transmitters, in which the crystal-controlled oscillators had been designed to measure both the temperature of the satellite shell and of the internal package.

  14. Satellite Videoconferences

    NASA Technical Reports Server (NTRS)

    1990-01-01

    NASA is helping thousands of teachers to learn more about aerospace matters, improve their classroom skills, and expand significantly the content of their aerospace education curricula by means of live educational satellite videoconferences. The 1 1/2 hour 'Update for Teachers' programs originate at Oklahoma State University (OSU) Telecommunications Center. The television signals are transmitted to the WESTAR IV communications satellite, which remits them to participating schools across the U.S. and in parts of Mexico and Canada. The schools are equipped with small home style satellite reception dishes. Education Satellite Videoconference programs are conducted four times yearly, covering a variety of aerospace subjects. Teachers can call toll-free and have questions answered after the speaker's presentations. Information about NASA educational resources and how to obtain them will be provided.

  15. Satellite positioning

    NASA Technical Reports Server (NTRS)

    Colombo, Oscar L.; Watkins, Michael M.

    1991-01-01

    Developments in satellite positioning techniques and their applications are reviewed on the basis of the theoretical and practical work published by U.S. researchers in 1987-1990. Current techniques are classified into two main categories: satellite laser tracking and radio tracking. Particular attention is given to the Geoscience Laser Ranging System, the Lunar Laser Ranging concept; GPS ephemerides determination, fiducial networks, and reference frame; static GPS positioning; and kinematic GPS positioning.

  16. Risk Factors for Nursing Home Placement in Alzheimer's Disease: A Longitudinal Study of Cognition, ADL, Service Utilization, and Cholinesterase Inhibitor Treatment

    ERIC Educational Resources Information Center

    Wattmo, Carina; Wallin, Asa K.; Londos, Elisabet; Minthon, Lennart

    2011-01-01

    Purpose of the Study: To identify risk factors for early nursing home placement (NHP) in Alzheimer's disease (AD), focusing on the impact of longitudinal change in cognition, activities of daily living (ADL), service utilization, and cholinesterase inhibitor treatment (ChEI). Design and Methods: In an open, 3-year, prospective, multicenter study…

  17. Risk Factors for Increased Hospital Resource Utilization and In-Hospital Mortality in Adults With Single Ventricle Congenital Heart Disease.

    PubMed

    Collins, Ronnie Thomas; Doshi, Pratik; Onukwube, Jennifer; Fram, Ricki Y; Robbins, James M

    2016-08-01

    Most patients with single ventricle congenital heart disease are now expected to survive to adulthood. Co-morbid medical conditions (CMCs) are common. We sought to identify risk factors for increased hospital resource utilization and in-hospital mortality in adults with single ventricle. We analyzed data from the 2001 to 2011 Nationwide Inpatient Sample database in patients aged ≥18 years admitted to nonteaching general hospitals (NTGHs), TGHs, and pediatric hospitals (PHs) with either hypoplastic left heart syndrome, tricuspid atresia or common ventricle. National estimates of hospitalizations were calculated. Elixhauser CMCs were identified. Length of stay (LOS), total hospital costs, and effect of CMCs were determined. Age was greater in NTGH (41.5 ± 1.3 years) than in TGH (32.8 ± 0.5) and PH (25.0 ± 0.6; p <0.0001). Adjusted LOS was shorter in NTGH (5.6 days) than in PH (9.7 days; p <0.0001). Adjusted costs were higher in PH ($56,671) than in TGH ($31,934) and NTGH ($18,255; p <0.0001). CMCs are associated with increased LOS (p <0.0001) and costs (p <0.0001). Risk factors for in-hospital mortality included increasing age (odds ratio [OR] 5.250, CI 2.825 to 9.758 for 45- to 64-year old vs 18- to 30-year old), male gender (OR 2.72, CI 1.804 to 4.103]), and the presence of CMC (OR 4.55, CI 2.193 to 9.436) for 2 vs none). No differences in mortality were found among NTGH, TGH, and PH. Cardiovascular procedures were more common in PH hospitalizations and were associated with higher costs and LOS. CMCs increase costs and mortality. In-hospital mortality is increased with age, male gender, and the presence of hypoplastic left heart syndrome.

  18. Clinical utility of panfungal polymerase chain reaction for the diagnosis of invasive fungal disease: a single center experience.

    PubMed

    Trubiano, J A; Dennison, A M; Morrissey, C O; Chua, K Y; Halliday, C L; Chen, S C-A; Spelman, D

    2016-02-01

    The role of panfungal polymerase chain reaction (PCR) assays for diagnosis of invasive fungal disease (IFD) is inadequately defined. We describe the use of an internal transcribed spacer 1 (ITS-1) region-directed panfungal PCR in this context at a tertiary referral transplant center. A retrospective review of patients at Alfred Health, Melbourne, Australia (2009-2014) who had clinical samples referred for panfungal PCR testing was conducted. Baseline patient characteristics, antifungal drug history, fungal culture/histopathology, and radiology results were recorded. For bronchoalveolar lavage (BAL) fluid samples, identification of a fungus other than a Candida spp. was defined as a potential pathogen.Of 138 panfungal PCR tests (108 patients), 41 (30%) were positive for a fungal product. Ninety-seven percent (134/138) of specimens were from immunocompromised hosts. Thirteen percent (19/138) of panfungal PCR positive results were for potential pathogens and potential pathogens were detected more frequently in tissue as compared with BAL (12/13 vs. 6/26; P = .0001). No positive panfungal PCR results were obtained from CSF specimens. If histopathology examination was negative, panfungal PCR identified a potential pathogen in only 12% (11/94) of specimens. For the 20 culture negative/histopathology positive specimens, diagnosis of IFD to causative species level by panfungal PCR occurred in 35% (6/20).Sterile site specimens, in particular tissue, were more frequently panfungal PCR positive for potential pathogens than BAL. The utility of panfungal PCR appears greatest in tissue specimens, as an adjunct to histopathology to improve diagnostic sensitivity and specificity. Based on the results of this study we are now only testing tissue specimens by panfungal PCR.

  19. Advanced Communications Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Gedney, Richard T.; Schertler, Ronald J.

    1989-01-01

    The NASA Advanced Communications Technology Satellite (ACTS) was conceived to help maintain U.S. leadership in the world's communications-satellite market. This experimental satellite is expected to be launched by NASA in 1992 and to furnish the technology necessary for establishing very small aperture terminal digital networks which provide on-demand full-mesh connectivity, and 1.544-MBPS services with only a single hop. Utilizing on-board switching and processing, each individual voice or data circuit can be separately routed to any location in the network. This paper provides an overview of the ACTS and discusses the value of the technology for future communications systems.

  20. Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease

    PubMed Central

    Puchakayala, Bharat K; Verma, Siddharth; Kanwar, Pushpjeet; Hart, John; Sanivarapu, Raghavendra R; Mohanty, Smruti R

    2015-01-01

    AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease (NAFLD) in patients with and without type 2 diabetes mellitus (T2DM) using updated nonalcoholic steatohepatitis clinical research network (NASH-CRN) grading system. METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2DM. This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author. The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison. The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist. The updated criteria for type 2 diabetes have been utilized for analysis. Background data of patients with NASH and NAFLD has been included. The mean differences were compared using χ2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis. RESULTS: Patients with NAFLD and T2DM were significantly older (49.9 vs 43.0, P < 0.01), predominantly female (71.4 vs 56.3, P < 0.02), had higher rate of metabolic syndrome (88.7 vs 36.4, P < 0.01), had significantly higher aspartate transaminase (AST)/alanine transaminase (ALT) ratio (0.94 vs 0.78, P < 0.01) and Fib-4 index (1.65 vs 1.06, P < 0.01) as markers of NASH, showed higher mean NAFLD activity score (3.5 vs 3.0, P = 0.03) and higher mean fibrosis score (1.2 vs 0.52, P < 0.01) compared to patients with NAFLD without T2DM. Furthermore, advanced fibrosis (32.5 vs 12.0, P < 0.01) and ballooning (27.3 vs 13.3, P < 0.01) was significantly higher among patients with NAFLD and T2DM compared to patients with NAFLD without T2DM. On multivariate analysis, T2DM was independently associated with NASH

  1. Gigabit Satellite Network for NASA's Advanced Communication Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Hoder, Douglas; Bergamo, Marcos

    1996-01-01

    The advanced communication technology satellite (ACTS) gigabit satellite network provides long-haul point-to-point and point-to-multipoint full-duplex SONET services over NASA's ACTS. at rates up to 622 Mbit/s (SONET OC-12), with signal quality comparable to that obtained with terrestrial fiber networks. Data multiplexing over the satellite is accomplished using time-division multiple access (TDMA) techniques coordinated with the switching and beam hopping facilities provided by ACTS. Transmissions through the satellite are protected with Reed-Solomon encoding. providing virtually error-free transmission under most weather conditions. Unique to the system are a TDMA frame structure and satellite synchronization mechanism that allow: (a) very efficient utilization of the satellite capacity: (b) over-the-satellite dosed-loop synchronization of the network in configurations with up to 64 ground stations: and (c) ground station initial acquisition without collisions with existing signalling or data traffic. The user interfaces are compatible with SONET standards, performing the function of conventional SONET multiplexers and. as such. can be: readily integrated with standard SONET fiber-based terrestrial networks. Management of the network is based upon the simple network management protocol (SNMP). and includes an over-the-satellite signalling network and backup terrestrial internet (IP-based) connectivity. A description of the ground stations is also included.

  2. Small satellites

    NASA Technical Reports Server (NTRS)

    Thomas, P.; Veverka, J.; Dermott, S.

    1986-01-01

    Satellites smaller than Mimas (r = 195 km) are distinguished by irregular overall shapes and by rough limb topography. Material properties and impact cratering dominate the shaping of these objects. Long fragmentation histories can produce a variety of internal structures, but so far there is no direct evidence that any small satellite is an equilibrium ellipsoid made up of noncohesive gravitationally bound rubble. One many bodies that orbit close to their primary the tidal and rotational components of surface gravity strongly affect the directions of local g and thereby affect the redistribution of regolith by mass wasting. Downslope movement of regolith is extensive on Deimos, and is probably effective on many other small satellites. It is shown that in some cases observed patterns of downslope mass wasting cold produce useful constraints on the satellite's mean density. The diversity of features seen in the few high-resolution images of small satellites currently available suggests that these objects have undergone complex histories of cratering, fragmentation, and regolith evolution.

  3. Continuation of the compendium of applications technology satellite and communications technology satellite user experiments 1967-1977, volume 2. [bibliography

    NASA Technical Reports Server (NTRS)

    Engler, N. A.; Nash, J. F.; Strange, J. D.

    1978-01-01

    Approximately 453 reports, papers, and articles catalogued into an information retrieval system, covering communications experiments and demonstrations conducted, utilizing the Communications Technology Satellite and the Applications Technology Satellites 1, 3, 5, and 6 are listed.

  4. Risk Factors for Increased Hospital Resource Utilization and In-Hospital Mortality in Adults With Single Ventricle Congenital Heart Disease.

    PubMed

    Collins, Ronnie Thomas; Doshi, Pratik; Onukwube, Jennifer; Fram, Ricki Y; Robbins, James M

    2016-08-01

    Most patients with single ventricle congenital heart disease are now expected to survive to adulthood. Co-morbid medical conditions (CMCs) are common. We sought to identify risk factors for increased hospital resource utilization and in-hospital mortality in adults with single ventricle. We analyzed data from the 2001 to 2011 Nationwide Inpatient Sample database in patients aged ≥18 years admitted to nonteaching general hospitals (NTGHs), TGHs, and pediatric hospitals (PHs) with either hypoplastic left heart syndrome, tricuspid atresia or common ventricle. National estimates of hospitalizations were calculated. Elixhauser CMCs were identified. Length of stay (LOS), total hospital costs, and effect of CMCs were determined. Age was greater in NTGH (41.5 ± 1.3 years) than in TGH (32.8 ± 0.5) and PH (25.0 ± 0.6; p <0.0001). Adjusted LOS was shorter in NTGH (5.6 days) than in PH (9.7 days; p <0.0001). Adjusted costs were higher in PH ($56,671) than in TGH ($31,934) and NTGH ($18,255; p <0.0001). CMCs are associated with increased LOS (p <0.0001) and costs (p <0.0001). Risk factors for in-hospital mortality included increasing age (odds ratio [OR] 5.250, CI 2.825 to 9.758 for 45- to 64-year old vs 18- to 30-year old), male gender (OR 2.72, CI 1.804 to 4.103]), and the presence of CMC (OR 4.55, CI 2.193 to 9.436) for 2 vs none). No differences in mortality were found among NTGH, TGH, and PH. Cardiovascular procedures were more common in PH hospitalizations and were associated with higher costs and LOS. CMCs increase costs and mortality. In-hospital mortality is increased with age, male gender, and the presence of hypoplastic left heart syndrome. PMID:27291967

  5. Utilization of information and communication technology (ICT) among sexually transmitted disease clinics attendees with coexisting drinking problems

    PubMed Central

    2014-01-01

    Background Alcohol misuse remains a major risk factor for contracting sexually transmitted diseases (STDs) not typically addressed in STD clinic settings. Information and communication technology (ICT) can offer new avenues to deliver evidence-based screening and treatment for problematic drinking, however, few data exists regarding the utilization of ICT among STD clinic attendees with coexisting drinking problems. The objectives of this study are to identify STD clinics attendees with hazardous drinking, to examine socio-demographic factors associated with ICT use, and to explore individuals’ interests in engaging in ICT-based health interventions. Methods Cross-sectional questionnaires examining alcohol consumption and ICT use were administered to 396 persons attending two non-urban STD clinics. Descriptive statistics for ICT use were calculated for both hazardous drinkers and the entire sample. Multivariable logistic regression models among hazardous drinkers identified factors significantly associated with use of each kind of ICT. Results The mean age of the 396 participants was 25 years, 66% were females and 60% were African-Americans. One third of the sample met the criteria of hazardous drinking. ICT use in hazardous drinkers included 94% reporting having internet access at least monthly, 82% reporting having an email account, 85% reporting currently owning a cell phone, and 91% reporting use of any cell phone application. More than two thirds (73%) of hazardous drinkers were willing to play health-related video games during clinic waiting time, slightly higher than the entire sample (69%). Multivariable analyses indicated that younger age were significantly related to monthly internet use, and multifunction cell phone use, while being males and younger age were significantly associated with monthly video game playing. Conclusions Our study demonstrates commonality of ICT use among STD clinic attendees with hazardous drinking, indicating the viability of

  6. Expectation versus Reality: The Impact of Utility on Emotional Outcomes after Returning Individualized Genetic Research Results in Pediatric Rare Disease Research, a Qualitative Interview Study

    PubMed Central

    Cacioppo, Cara N.; Chandler, Ariel E.; Towne, Meghan C.; Beggs, Alan H.; Holm, Ingrid A.

    2016-01-01

    Purpose Much information on parental perspectives on the return of individual research results (IRR) in pediatric genomic research is based on hypothetical rather than actual IRR. Our aim was to understand how the expected utility to parents who received IRR on their child from a genetic research study compared to the actual utility of the IRR received. Methods We conducted individual telephone interviews with parents who received IRR on their child through participation in the Manton Center for Orphan Disease Research Gene Discovery Core (GDC) at Boston Children’s Hospital (BCH). Results Five themes emerged around the utility that parents expected and actually received from IRR: predictability, management, family planning, finding answers, and helping science and/or families. Parents expressing negative or mixed emotions after IRR return were those who did not receive the utility they expected from the IRR. Conversely, parents who expressed positive emotions were those who received as much or greater utility than expected. Conclusions Discrepancies between expected and actual utility of IRR affect the experiences of parents and families enrolled in genetic research studies. An informed consent process that fosters realistic expectations between researchers and participants may help to minimize any negative impact on parents and families. PMID:27082877

  7. Small Satellite Access of the Space Network

    NASA Technical Reports Server (NTRS)

    Horan, Stephen; Minnix, Timothy O.; Vigil, J. S.

    1999-01-01

    Small satellites have been perceived as having limited access to NASA's Space Network (SN). The potential for satellite access of the space network when the design utilizes a fixed antenna configuration and low-power, coded transmission is analyzed. From the analysis, satellites using this configuration in high-inclination orbits are shown to have a daily data throughput in the 100 to 1000 Mbit range using the multiple access communications service.

  8. The utility of cerebral blood flow imaging in patients with the unique syndrome of progressive dementia with motor neuron disease

    SciTech Connect

    Ohnishi, T.; Hoshi, H.; Jinnouchi, S.; Nagamachi, S.; Watanabe, K.; Mituyama, Y. )

    1990-05-01

    Two patients presenting with progressive dementia coupled with motor neuron disease underwent brain SPECT using N-isopropyl-p iodine-123-iodoamphetamine (({sup 123}I)IMP). The characteristic clinical features of progressive dementia and motor neuron disease were noted. IMP SPECT also revealed reduced uptake in the bilateral frontal and temporal regions, with no reduction of uptake in the parietal, parietal-occipital regions. We conclude that IMP SPECT has potential for the evaluation of progressive dementia with motor neuron disease.

  9. Building Satellites is Easier

    NASA Technical Reports Server (NTRS)

    Marsh, Phyllis Nimmo

    1996-01-01

    'Building Satellites' is a story about Jim Marsh's recovery from a severe head injury told by his wife Phyllis from the moment she learned of its happening, through the ups and downs of a lengthy rehabilitation, until his return to work and daily living. It continues on, however, and narrates his battle with the more insidious Grave's disease. Told in the first person, 'Building Satellites' vividly portrays Phyllis's thoughts and feelings throughout this experience with scrupulous honestly. This is a story worth reading for many reasons. First of all, Jim was an accomplished scientist, respected by his colleagues both in this country and abroad. Secondly, it narrates the many stages of his recovery from head injury with detailed readable accuracy; it informs us as well as inspires. Finally, 'Building Satellites" also tells us the story of Phyllis Marsh's remarkable creative response to this crisis. It narrates her personal experiences as she progresses through the strange and somewhat bizarre world of medicine and rehabilitation, guided by a few basic beliefs, which she learned as a child in Iowa, that provided her with the strength to endure. 'Building Satellites' seems to reaffirm our unconscious, but settled conviction, that when confornted overnight with adversity, we are somehow given the means for coping, supported by our basic beliefs, strengthened by family and friends, and eventually learning to accept any outcome.

  10. Perception via satellite

    USGS Publications Warehouse

    Robinove, Charles J.

    1970-01-01

    The earth resources observation satellite (EROS) program in the Department of the Interior is intended to gather and use data from satellites and aircraft on natural and man-made features of the earth's surface. Earth resources technology satellite will provide the EROS program with data for use in dealing with natural resource problems and understanding the interaction between man and the environment. Applications will include studies of tectonic features, hydrologic problems, location of fish schools, determination of the conditions of range land, mapping land use for urban planning, studies of erosion and change along coastlines and major streams, and inventories of land use and land forms. In addition, the ERTS data may be used for detecting forest and crop diseases and inventorying crops. The ERTS satellite will be in a polar, sun-synchronous orbit so that each point on the earth's surface will be sensed every 17 to 20 days, at the same time of day. Multispectral photography is being investigated for its usefulness in hydrology. Side-looking airborne radar has not yet been widely used in hydrologic studies, although it is an excellent tool for all-weather, day or night, coverage of large areas. Other techniques being investigated include passive microwave radiometry, ultraviolet and visible stimulated luminescence, and absorption spectroscopy.

  11. The Roles of Chronic Disease Complexity, Health System Integration, and Care Management in Post-Discharge Healthcare Utilization in a Low-Income Population.

    PubMed

    Hewner, Sharon; Casucci, Sabrina; Castner, Jessica

    2016-08-01

    Economically disadvantaged individuals with chronic disease have high rates of in-patient (IP) readmission and emergency department (ED) utilization following initial hospitalization. The purpose of this study was to explore the relationships between chronic disease complexity, health system integration (admission to accountable care organization [ACO] hospital), availability of care management interventions (membership in managed care organization [MCO]), and 90-day post-discharge healthcare utilization. We used de-identified Medicaid claims data from two counties in western New York. The study population was 114,295 individuals who met inclusion criteria, of whom 7,179 had index hospital admissions in the first 9 months of 2013. Individuals were assigned to three disease complexity segments based on presence of 12 prevalent conditions. The 30-day inpatient (IP) readmission rates ranged from 6% in the non-chronic segment to 12% in the chronic disease complexity segment and 21% in the organ system failure complexity segment. Rehospitalization rates (both inpatient and emergency department [ED]) were lower for patients in MCOs and ACOs than for those in fee-for-service care. Complexity of chronic disease, initial hospitalization in a facility that was part of an ACO, MCO membership, female gender, and longer length of stay were associated with a significantly longer time to readmission in the first 90 days, that is, fewer readmissions. Our results add to evidence that high-value post-discharge utilization (fewer IP or ED rehospitalizations and early outpatient follow-up) require population-based transitional care strategies that improve continuity between settings and take into account the illness complexity of the Medicaid population. © 2016 Wiley Periodicals, Inc. PMID:27284973

  12. Visual Data Analysis for Satellites

    NASA Technical Reports Server (NTRS)

    Lau, Yee; Bhate, Sachin; Fitzpatrick, Patrick

    2008-01-01

    The Visual Data Analysis Package is a collection of programs and scripts that facilitate visual analysis of data available from NASA and NOAA satellites, as well as dropsonde, buoy, and conventional in-situ observations. The package features utilities for data extraction, data quality control, statistical analysis, and data visualization. The Hierarchical Data Format (HDF) satellite data extraction routines from NASA's Jet Propulsion Laboratory were customized for specific spatial coverage and file input/output. Statistical analysis includes the calculation of the relative error, the absolute error, and the root mean square error. Other capabilities include curve fitting through the data points to fill in missing data points between satellite passes or where clouds obscure satellite data. For data visualization, the software provides customizable Generic Mapping Tool (GMT) scripts to generate difference maps, scatter plots, line plots, vector plots, histograms, timeseries, and color fill images.

  13. Managing Satellites

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Integral Systems, Inc.'s EPOCH 2000 forms the core of NASA's Near Earth Asteroid Rendezvous (NEAR) mission's command and control center. EPOCH 2000, which allows ground operators to monitor and control satellites over a wide area network, owes part of its heritage from work completed to support Goddard Space Flight Center. The software automates telemetry processing, commanding, anomaly detection, and archiving collected data. The NEAR spacecraft, launched in February 1996, will rendezvous in early 1999 and orbit the Asteroid Eros for a year. Integral Systems also provided Low Earth Orbit Autonomous Ground Terminals (LEO-Ts) to NASA. The LEO-T is designed to make it easier and less expensive for principal investigators to obtain telemetry, tracking and control services for their science missions. The company products have supported well over 70 satellite missions aimed at scientific research, meteorology, or communications applications.

  14. Applications of Communications Satellites in Higher Education.

    ERIC Educational Resources Information Center

    Morgan, Robert P.

    Early experiments with the ATS-1 and ATS-3 satellites utilized one way and two way audio for a variety of university purposes, and several different television modes were employed in the ATS-6 satellite. Among the higher education activities on ATS-6 were inservice teacher education and the facilitation of regionalized medical education. A college…

  15. Virtual Satellite

    NASA Technical Reports Server (NTRS)

    Hammrs, Stephan R.

    2008-01-01

    Virtual Satellite (VirtualSat) is a computer program that creates an environment that facilitates the development, verification, and validation of flight software for a single spacecraft or for multiple spacecraft flying in formation. In this environment, enhanced functionality and autonomy of navigation, guidance, and control systems of a spacecraft are provided by a virtual satellite that is, a computational model that simulates the dynamic behavior of the spacecraft. Within this environment, it is possible to execute any associated software, the development of which could benefit from knowledge of, and possible interaction (typically, exchange of data) with, the virtual satellite. Examples of associated software include programs for simulating spacecraft power and thermal- management systems. This environment is independent of the flight hardware that will eventually host the flight software, making it possible to develop the software simultaneously with, or even before, the hardware is delivered. Optionally, by use of interfaces included in VirtualSat, hardware can be used instead of simulated. The flight software, coded in the C or C++ programming language, is compilable and loadable into VirtualSat without any special modifications. Thus, VirtualSat can serve as a relatively inexpensive software test-bed for development test, integration, and post-launch maintenance of spacecraft flight software.

  16. Satellite RNAs of plant viruses: structures and biological effects.

    PubMed Central

    Roossinck, M J; Sleat, D; Palukaitis, P

    1992-01-01

    Plant viruses often contain parasites of their own, referred to as satellites. Satellite RNAs are dependent on their associated (helper) virus for both replication and encapsidation. Satellite RNAs vary from 194 to approximately 1,500 nucleotides (nt). The larger satellites (900 to 1,500 nt) contain open reading frames and express proteins in vitro and in vivo, whereas the smaller satellites (194 to 700 nt) do not appear to produce functional proteins. The smaller satellites contain a high degree of secondary structure involving 49 to 73% of their sequences, with the circular satellites containing more base pairing than the linear satellites. Many of the smaller satellites produce multimeric forms during replication. There are various models to account for their formation and role in satellite replication. Some of these smaller satellites encode ribozymes and are able to undergo autocatalytic cleavage. The enzymology of satellite replication is poorly understood, as is the replication of their helper viruses. In many cases the coreplication of satellites suppresses the replication of the helper virus genome. This is usually paralleled by a reduction in the disease induced by the helper virus; however, there are notable exceptions in which the satellite exacerbates the pathogenicity of the helper virus, albeit on only a limited number of hosts. The ameliorative satellites are being assessed as biocontrol agents of virus-induced disease. In greenhouse studies, satellites have been known to "spontaneously" appear in virus cultures. The possible origin of satellites will be briefly considered. PMID:1620065

  17. LDEF satellite radiation study

    NASA Technical Reports Server (NTRS)

    Armstrong, T. W.; Colborn, B. L.

    1994-01-01

    Some early results are summarized from a program under way to utilize LDEF satellite data for evaluating and improving current models of the space radiation environment in low earth orbit. Reported here are predictions and comparisons with some of the LDEF dose and induced radioactivity data, which are used to check the accuracy of current models describing the magnitude and directionality of the trapped proton environment. Preliminary findings are that the environment models underestimate both dose and activation from trapped protons by a factor of about two, and the observed anisotropy is higher than predicted.

  18. Validation of Satellite Retrieved Land Surface Variables

    NASA Technical Reports Server (NTRS)

    Lakshmi, Venkataraman; Susskind, Joel

    1999-01-01

    The effective use of satellite observations of the land surface is limited by the lack of high spatial resolution ground data sets for validation of satellite products. Recent large scale field experiments include FIFE, HAPEX-Sahel and BOREAS which provide us with data sets that have large spatial coverage and long time coverage. It is the objective of this paper to characterize the difference between the satellite estimates and the ground observations. This study and others along similar lines will help us in utilization of satellite retrieved data in large scale modeling studies.

  19. Linkage disequilibrium utilized to establish a refined genetic position of the Salla disease locus on 6q14-q15

    SciTech Connect

    Schleutker, J.; Laine, A.P.; Haataja, L. |

    1995-05-20

    Salla disease (SD), an inherited free sialic acid storage disorder, is caused by impaired transport of free sialic acid across the lyosomal membrane. Clinical characteristics of the disease include severe psychomotor retardation and some neurological abnormalities. The authors report detailed linkage analyses of 50 Finnish SD families that localize the SD disease gene to a refined chromosomal area on 6q14-q15. The highest lod score of 17.30 was obtained with a microsatellite marker of locus D6S280. When linkage disequilibrium was adopted in the linkage analyses, they could further assign the SD locus to the immediate vicinity of marker locus D6S406. Linkage disequilibrium facilitated further restriction of the critical chromosomal region to approximately 80 kb, well within the limits of positional cloning techniques. 31 refs., 3 figs., 3 tabs.

  20. Meeting report: panel on the potential utility and strategies for design and implementation of a national companion animal infectious disease surveillance system.

    PubMed

    Stone, A B; Hautala, J A

    2008-10-01

    This meeting report summarizes the discussions and recommendations of a Blue Ribbon Panel convened by the Science and Technology Policy Institute at the Institute for Defense Analysis on behalf of the White House Office of Science and Technology Policy (OSTP) on 13 September 2006 to discuss the potential utility and possible strategies for design and implementation of a companion animal health surveillance system. The panel comprised representatives from federal agencies, state agencies, academia, professional societies, and the private sector. The panel concluded that a companion animal surveillance system might prove valuable to efforts to protect public health, but that further study of the relationship between companion animal health and human health were needed to assess the utility and potential applications of a companion animal surveillance system. The findings of this panel may be used, along with other important sources of information, to inform policy discussions focussed on identifying strategies for recognizing and monitoring zoonotic disease threats appearing in companion animals in the USA.

  1. Meteorological satellites

    NASA Astrophysics Data System (ADS)

    1981-10-01

    Meteor-2 (second generation meteorological satellite) and an experimental satellite on which instruments are being tested and modified for the requirements of hydrometeorology and a determination of natural resources are presently operational in the U.S.S.R. Television devices with a 1-10 km terrain image resolution operating in the visible and infrared region are used to determine the space system, velocity and direction of cloud movements and provide information about the snow and ice cover, cyclones, storms, vortices in the atmosphere, and velocity and direction of wind. Images with a 50-1000 m resolution make possible geological and hydrological surveys, an evaluation of the state of vegetation and crops, detection of forest fires, determination of pollution of the atmosphere and sea and determination of optimal fishing regions in the ocean. Measurement of the intensity of atmospheric radiation in narrow infrared regions and very high frequencies allows remote evaluation of the temperature and humidity distribution in the vertical cross section of the Earth's atmosphere.

  2. The utility of polymerase chain reaction for diagnosis of lumpy skin disease in cattle and water buffaloes in Egypt.

    PubMed

    Sharawi, S S A; Abd El-Rahim, I H A

    2011-12-01

    An outbreak of lumpy skin disease (LSD) occurred among cattle and water buffaloes in Egypt in 2006. Polymerase chain reaction (PCR) and the agar gel precipitation test (AGPT) were compared. Eight of ten (80%) tissue specimens from diseased cattle were positive with AGPT while 100% were positive with PCR. Of ten tissue specimens from diseased water buffaloes, 70% were positive with AGPT while 100% were positive with PCR. Ten milk samples were obtained from diseased water buffaloes; PCR detected nucleic acid of LSD virus (LSDV) in 50% while AGPT failed to detect LSDV antigen. Water buffaloes are susceptible to LSDV infection. The clinical signs of LSD were less severe in water buffaloes, but the virus was excreted in their milk. Diagnosis of LSD outbreaks by PCR will facilitate rapid application of control measures. Mass vaccination should be applied in both cattle and water buffaloes in Egypt using an effective specific vaccine against LSD, such as the attenuated Neethling strain vaccine or a recombinant vaccine.

  3. Utility of fecal calprotectin in differentiating inflammatory bowel disease (IBD) from recurrent abdominal pain (RAP) in children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: It often is difficult to differentiate IBD from RAP in children. Fecal calprotectin concentration has been proposed as a marker to identify gastrointestinal inflammation and it may be useful in distinguishing organic disease (i.e., IBD) from normals. However, there are scant data regardi...

  4. Host colonization and substrate utilization by wood-colonizing Ascomycete fungi in the grapevine trunk disease complex

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Grapevine trunk diseases cause chronic wood infections (cankers) in mixed infections within the same vine. To determine the synergistic interactions of trunk-pathogen communities and their impact on the host we are characterizing, on a pathogen-by-pathogen basis, fungal damage to woody cells and tis...

  5. A design tool for small satellites: SMALLSAT

    NASA Astrophysics Data System (ADS)

    Greenberg, Joel S.; McCandless, Walt

    1996-03-01

    SMALLSAT is a computer-aided Phase A design and technology evaluation tool for small satellites. SMALLSAT enables satellite designers, mission planners, and technology program managers to observe the likely consequences of their decisions in terms of satellite configuration and mission life cycle costs and availability statistics. SMALLSAT configures a satellite in terms of mission parameters, sensor attributes, and bus subsystem technology with nine interrelated subsystems considered: attitude reference and control, power, thermal, orbital maintenance, propulsion, data handling, on-boardcomputer, TT&C, and structure. Sensor, satellite, launch vehicle, and technology databases are contained within the model. As a satellite is configured, a set of cost estimating relationships (specifically developed for smallsats by the Aerospace Corp.) is utilized to provide estimates of both nonrecurring and unit recurring costs at the subsystem level. An integrated Monte Carlo simulation model may be used to determine resulting life cycle cost and availability statistics.

  6. Outer planet satellites

    NASA Astrophysics Data System (ADS)

    Schenk, Paul M.

    Recent findings on the outer-planet satellites are presented, with special consideration given to data on the rheologic properties of ice on icy satellites, the satellite surfaces and exogenic processes, cratering on dead cratered satellites, volcanism, and the interiors of outer-planet satellites. Particular attention is given to the state of Titan's surface and the properties of Triton, Pluto, and Charon.

  7. Severe storms observing satellite (STORMSAT)

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The primary payload for this satellite is the Advanced Atmospheric Sounding and Imaging Radiometer which will perform precise infrared temperature sounding and visible/infrared imaging from geostationary orbit. A secondary payload instrument which may be utilized on STORMSAT is the Microwave Atmospheric Sounding Radiometer which provides an independent set of temperature and humidity sounding in cloudy, meteorologically active regions. The study provides satellite designs and identifies mission-unique subsystems using the Multimission Modular Spacecraft using a Shuttle/Interim Upper Stage launch vehicle.

  8. Chronic obstructive pulmonary disease in African- and European-American women: morbidity, mortality and healthcare utilization in the USA.

    PubMed

    Mehari, Alem; Gillum, Richard F

    2015-04-01

    The impact of chronic obstructive pulmonary disease (COPD) is increasing in US women. In 2008-2010, an estimated 7.9 million US women were living with COPD. Chronic lower respiratory disease was the third leading cause of mortality in 2010 and was a major cause of morbidity. Its economic and social burden is both substantial and increasing in the USA. The annual number of COPD deaths is now higher in women than in men. In 2011, 72,584 women and 65,920 men aged 25 years and over died of COPD. The death rate in African-American women was only half compared with European-American women. Further, rates of COPD prevalence, emergency room visits and hospitalization were greater among women than men. This review reports the latest patterns and trends in several measures of COPD in US women.

  9. The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature.

    PubMed

    Simonsen, Anja Hviid; Kuiperij, Bea; El-Agnaf, Omar Mukhtar Ali; Engelborghs, Sebastian; Herukka, Sanna-Kaisa; Parnetti, Lucilla; Rektorova, Irena; Vanmechelen, Eugeen; Kapaki, Elisabeth; Verbeek, Marcel; Mollenhauer, Brit

    2016-01-01

    The discovery of α-synuclein (α-syn) as a major component of Lewy bodies, neuropathological hallmark of Parkinson's disease (PD), dementia with Lewy bodies and of glial inclusions in multiple system atrophy initiated the investigation of α-syn as a biomarker in cerebrospinal fluid (CSF). Due to the involvement of the periphery in PD the quantification of α-syn in peripheral fluids such as serum, plasma and saliva has been investigated as well. We review how the development of multiple assays for the quantification of α-syn has yielded novel insights into the variety of α-syn species present in the different fluids; the optimal preanalytical conditions required for robust quantification and the potential clinical value of α-syn as biomarker. We also suggest future approaches to use of CSF α-syn in neurodegenerative diseases.

  10. Utilization and Accessibility of Healthcare on Pemba Island, Tanzania: Implications for Health Outcomes and Disease Surveillance for Typhoid Fever

    PubMed Central

    Kaljee, Linda M.; Pach, Alfred; Thriemer, Kamala; Ley, Benedikt; Ali, Said M.; Jiddawi, Mohamed; Puri, Mahesh; von Seidlein, Lorenz; Deen, Jacqueline; Ochiai, Leon; Wierzba, Thomas; Clemens, John

    2013-01-01

    Salmonella enterica serotype Typhi (S. Typhi) was estimated to cause over 200,000 deaths and more than 21 million illnesses worldwide, including over 400,000 illnesses in Africa. The current study was conducted in four villages on Pemba Island, Zanzibar, in 2010. We present data on policy makers', health administrators', and village residents' and leaders' perceptions of typhoid fever, and hypothetical and actual health care use among village residents for typhoid fever. Qualitative data provided descriptions of home-based treatment practices and use of western pharmaceuticals, and actual healthcare use for culture-confirmed typhoid fever. Survey data indicate health facility use was associated with gender, education, residency, and perceptions of severity for symptoms associated with typhoid fever. Data have implications for education of policy makers and health administrators, design and implementation of surveillance studies, and community-based interventions to prevent disease outbreaks, decrease risks of complications, and provide information about disease recognition, diagnosis, and treatment. PMID:23208887

  11. Satellite altimetry

    NASA Technical Reports Server (NTRS)

    Cheney, Robert E.

    1992-01-01

    Since altimetry data are not really old enough to use the term data archaeology, Mr. Cheney referred to the stewardship of these data. He noted that it is very important to document the basis for an altimetry data set as the algorithms and corrections used to arrive at the Geophysical Data Record (GDR) have been improving and are continuing to improve the precision of sea level data derived from altimetry. He noted that the GEOSAT Exact Repeat Mission (ERM) data set has recently been reprocessed by his organization in the National Ocean Service of NOAA and made available to the scientific community on CD/ROM disks by the National Oceanographic Data Center of the U.S. (NODC). The new data set contains a satellite orbit more precise by an order of magnitude together with an improved water vapor correction. A new, comprehensive GDR Handbook has also been prepared.

  12. A morphological study of the pacemaker cells of the aganglionic intestine in Hirschsprung's disease utilizing ls/ls model mice.

    PubMed

    Taniguchi, Kan; Matsuura, Kimio; Matsuoka, Takanori; Nakatani, Hajime; Nakano, Takumi; Furuya, Yasuo; Sugimoto, Takeki; Kobayashi, Michiya; Araki, Keijiro

    2005-06-01

    Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observed at the level of the intermuscular layer corresponding to Auerbach's plexus using ls/ls mice. These mice are an ideal model because of their large intestinal aganglionosis and gene abnormalities, which are similar to the human form of the disease. Immunostaining using anti-c-kit receptor antibody (ACK2), a marker of PMC, applied to whole-mount muscle-layer specimens, revealed the presence of c-kit immunopositive multipolar cells with many cytoplasmic processes in normal mice. For ls/ls mice, however, there were significantly fewer processes. The average number of processes per positive cell of 2.5 for the aganglionic large intestine was fewer than 3.5 for the large and small intestine of normal mice, indicating the inability to form connections between nerves and PMC in the aganglionic intestine. For normal mice with an Auerbach's plexus, the process attachment of ICC to the Auerbach's plexus was observed by scanning electron microscopy. However, for ls/ls mice no attachment to the intermuscular nerve without Auerbach's plexus was found, although transmission electron microscopy showed no difference in the cell structure and organelles of the c-kit immunopositive cells between the normal and ls/ls mice. These findings suggest that in the aganglionic intestine of Hirschsprung's disease, aplasia of enteric ganglia induces secondary disturbances during the normal development of intestinal PMC.

  13. ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas

    PubMed Central

    Hong, Sangjin; Pedersen, Peter L.

    2008-01-01

    Summary: ATP synthase, a double-motor enzyme, plays various roles in the cell, participating not only in ATP synthesis but in ATP hydrolysis-dependent processes and in the regulation of a proton gradient across some membrane-dependent systems. Recent studies of ATP synthase as a potential molecular target for the treatment of some human diseases have displayed promising results, and this enzyme is now emerging as an attractive molecular target for the development of new therapies for a variety of diseases. Significantly, ATP synthase, because of its complex structure, is inhibited by a number of different inhibitors and provides diverse possibilities in the development of new ATP synthase-directed agents. In this review, we classify over 250 natural and synthetic inhibitors of ATP synthase reported to date and present their inhibitory sites and their known or proposed modes of action. The rich source of ATP synthase inhibitors and their known or purported sites of action presented in this review should provide valuable insights into their applications as potential scaffolds for new therapeutics for human and animal diseases as well as for the discovery of new pesticides and herbicides to help protect the world's food supply. Finally, as ATP synthase is now known to consist of two unique nanomotors involved in making ATP from ADP and Pi, the information provided in this review may greatly assist those investigators entering the emerging field of nanotechnology. PMID:19052322

  14. Global Positioning System Satellite Selection Method

    NASA Technical Reports Server (NTRS)

    Niles, Frederick A. (Inventor)

    2001-01-01

    The satellite selection method as utilized by the spaceborne Global Positioning System receiver provides navigational solutions and is designed for use in low Earth orbit. The satellite selection method is a robust algorithm that can be used a GPS receiver to select appropriate GPS satellites for use in calculating point solutions or attitude solutions. The method is takes into account the difficulty of finding a particular GPS satellite phase code, especially when the search range in greatly increased due to Doppler shifts introduced into the carrier frequency. The method starts with an update of the antenna pointing and spacecraft vectors to determine the antenna backplane direction. Next, the GPS satellites that will potentially be in view of the antenna are ranked on a list, whereby the list is generated based on the estimated attitude and position of each GPS satellite. Satellites blocked by the Earth are not entered on this list. A second list is created, whereby the GPS satellites are ranked according to their desirability for use in attitude determination. GPS satellites are ranked according to their orthogonality to the antenna backplane, and according to geometric dilution of precision considerations. After the lists are created, the channels of the spaceborne GPS receiver are assigned to various GPS satellites for acquisition and lock. Preliminary Doppler frequencies for searching are assigned to the various channels.

  15. Differential prognostic utility of NTproBNP and Cystatin C in patients with acute exacerbation of chronic pulmonary disease

    PubMed Central

    Pérez-Calvo, Juan I; Sánchez-Marteles, Marta; Ruiz-Ruiz, Francisco-José; Morales-Rull, José-Luis; Nieto-Rodríguez, José-Antonio

    2010-01-01

    Objectives To determine whether serum Cystatin C (CysC) and NTproBNP have prognostic value among patients with long-standing chronic lung disease. Design Prospective, observational, non-interventional study. Setting CysC and NTproBNP are prognostic markers in several cardiac conditions. In addition, CysC acts as an antiprotease following Cathepsin activation, which has been involved in the pathogenesis of chronic obstructive pulmonary disease. Participants Patients with a basal functional status of II-IV (NYHA), admitted for an acute exacerbation of chronic pulmonary diseases and no previous history of symptoms related to pulmonary hypertension or heart failure. Main outcome measures NTproBNP and CysC were determined at admission in 107 patients with acute exacerbation of chronic lung disease. During 12-month follow-up, mortality, new hospital admissions and prescription of diuretics were recorded. Results During follow-up there were eight patient deaths (7.5%). Mean NTproBNP among the deceased was 1510.20 pg/mL (95% CI 498.44–4628.55) vs 502.70 pg/mL (95% CI 395.44–645.48) among survivors (p = 0.01). Twenty-seven patients (25%) were prescribed loop diuretics. Mean concentration of CysC was 1.45 mg/dL (95% CI 1.21–1.69 mg/dL) vs 1.17 mg/dL (95% IC 1.09–1.25 mg/dL) in those not prescribed (p = 0.004). NTproBNP concentration was 837.14 pg/mL (95% CI 555.57–1274.10 pg/mL) in patients prescribed diuretics vs 473.42 pg/mL (95% CI 357.80–632.70 pg/mL) in those not prescribed (p = 0.03). Kaplan-Meier analysis revealed a significant difference between death and diuretic prescription during follow-up when cut-off value for NTproBNP was 550 pg/mL (p = 0.03 and p = 0.02, respectively). For 1.16mg/dL of CsysC, a significant difference was only observed in diuretic prescription (p = 0.007). Conclusions In patients with chronic respiratory diseases NTproBNP has predictive value in terms of mortality whereas CysC does not. However, it is still possible that both can

  16. Satellite height determination using satellite-to-satellite tracking and ground laser systems

    NASA Technical Reports Server (NTRS)

    Vonbun, F. O.

    1972-01-01

    The height of the GEOS-C spacecraft was utilized as measured by the onboard radar altimeter, for an improved determination of the earth's gravitational field and for the determination of the variation of the physical surface of the oceans. Two tracking system approaches to accurately determine the spacecraft height (orbit) are described and their results stated. These are satellite-to-satellite tracking (SST) and ground laser tracking (GLT). Height variations can be observed in the dm-regions using SST and in the m-region using present GLT.

  17. Satellites in Education.

    ERIC Educational Resources Information Center

    Jones, David

    1988-01-01

    Describes the methods and materials used to obtain satellite pictures from weather satellites. Discusses possible physics lessons which can be done using this equipment including orbital mechanics, and how the satellite works. (CW)

  18. Satellite communications for the Pacific islands. Second year report

    NASA Technical Reports Server (NTRS)

    Young, E.; Hurd, J. N.

    1982-01-01

    Requirements, options and costs for use of communications satellites in underserved areas of the Pacific Basin are described with emphasis on extended utilization of INTELSAT. The economic structures within and among Pacific Basin entities are examined, particularly the relationship between the growth of regional trade and telecommunications potential for the region. Suitable satellite services are recommended and the financial implications for extended utilization of communications satellites in the Pacific Basin are considered.

  19. A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches.

    PubMed

    Cosgrove, Benjamin D; Sacco, Alessandra; Gilbert, Penney M; Blau, Helen M

    2009-01-01

    Satellite cells are skeletal muscle stem cells with a principal role in postnatal skeletal muscle regeneration. Satellite cells, like many tissue-specific adult stem cells, reside in a quiescent state in an instructive, anatomically defined niche. The satellite cell niche constitutes a distinct membrane-enclosed compartment within the muscle fiber, containing a diversity of biochemical and biophysical signals that influence satellite cell function. A major limitation to the study and clinical utility of satellite cells is that upon removal from the muscle fiber and plating in traditional plastic tissue culture platforms, their muscle stem cell properties are rapidly lost. Clearly, the maintenance of stem cell function is critically dependent on in vivo niche signals, highlighting the need to create novel in vitro microenvironments that allow for the maintenance and propagation of satellite cells while retaining their potential to function as muscle stem cells. Here, we discuss how emerging biomaterials technologies offer great promise for engineering in vitro microenvironments to meet these challenges. In engineered biomaterials, signaling molecules can be presented in a manner that more closely mimics cell-cell and cell-matrix interactions, and matrices can be fabricated with diverse rigidities that approximate in vivo tissues. The development of in vitro microenvironments in which niche features can be systematically modulated will be instrumental not only to future insights into muscle stem cell biology and therapeutic approaches to muscle diseases and muscle wasting with aging, but also will provide a paradigm for the analysis of numerous adult tissue-specific stem cells.

  20. Advanced Communications Technology Satellite (ACTS)

    NASA Technical Reports Server (NTRS)

    Plecity, Mark S.; Nall, Mark E.

    1991-01-01

    The NASA Advanced Communications Technology Satellite (ACTS) provides high risk technologies having the potential to dramatically enhance the capabilities of the satellite communications industry. This experimental satellite, which will be launched by NASA in 1993, will furnish the technology necessary for providing a range of services. Utilizing the ACTS very-high-gain-hopping spot-beam antennas with on-board routing and processing, Very Small Aperture Terminal (VSAT) digital networks which provide on-demand, full-mesh-convectivity 1.544-MBPS services with only a single hop can be established. The high-gain spot-beam antenna at Ka-band permits wide area, flexible networks providing high data rate services between modest-size earth terminals.

  1. The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease

    PubMed Central

    Abej, Esmail

    2016-01-01

    Objectives. To determine the relationship between fecal calprotectin (FCAL) and imaging studies and other biochemical inflammatory markers and the impact of FCAL measurements on decision-making in IBD patient management in usual clinical practice. Methods. 240 persons with IBD were enrolled. The correlation between FCAL values and other markers for disease activity such as serum albumin (alb), hemoglobin (Hg), and C-reactive protein (CRP) and diagnostic imaging or colonoscopy was examined. FCAL ≥ 250 mcg/g of stool was considered a positive result indicating active IBD. Results. 183 stool samples (76.3%) were returned. The return rate in the pediatric and adult cohorts was 91% (n = 82) and 67.3% (n = 101), respectively (P < 0.0001). Positive FCAL was associated with colonoscopy findings of active IBD (P < 0.05), low albumin (P < 0.05), anemia (P < 0.01), and elevated CRP (P < 0.01). There was no significant difference for FCAL results by outcomes on small bowel evaluation among the 21 persons with small bowel CD. Most persons (87.5%) with normal FCAL and no change in therapy remained in remission during subsequent 3 months. Conclusions. FCAL is a useful marker of disease activity and a valuable tool in managing persons with IBD in clinical practice. Clinicians have to be cautious in interpreting FCAL results in small bowel CD. PMID:27774443

  2. Subtle learning and memory impairment in an idiopathic rat model of Alzheimer's disease utilizing cholinergic depletions and β-amyloid.

    PubMed

    Deibel, S H; Weishaupt, N; Regis, A M; Hong, N S; Keeley, R J; Balog, R J; Bye, C M; Himmler, S M; Whitehead, S N; McDonald, R J

    2016-09-01

    Alzheimer's disease (AD) is a disease of complex etiology, involving multiple risk factors. When these risk factors are presented concomitantly, cognition and brain pathology are more severely compromised than if those risk factors were presented in isolation. Reduced cholinergic tone and elevated amyloid-beta (Aβ) load are pathological hallmarks of AD. The present study sought to investigate brain pathology and alterations in learning and memory when these two factors were presented together in rats. Rats received either sham surgeries, cholinergic depletions of the medial septum, intracerebroventricular Aβ25-35 injections, or both cholinergic depletion and Aβ25-35 injections (Aβ+ACh group). The Aβ+ACh rats were unimpaired in a striatal dependent visual discrimination task, but had impaired acquisition in the standard version of the Morris water task. However, these rats displayed normal Morris water task retention and no impairment in acquisition of a novel platform location during a single massed training session. Aβ+ACh rats did not have exacerbated brain pathology as indicated by activated astroglia, activated microglia, or accumulation of Aβ. These data suggest that cholinergic depletions and Aβ injections elicit subtle cognitive deficits when behavioural testing is conducted shortly after the presentation of these factors. These factors might have altered hippocampal synaptic plasticity and thus resemble early AD pathology. PMID:27208489

  3. Assessing the potential clinical utility of transplantations of neural and mesenchymal stem cells for treating neurodegenerative diseases.

    PubMed

    Lescaudron, Laurent; Boyer, C; Bonnamain, Virginie; Fink, K D; Lévêque, X; Rossignol, J; Nerrière-Daguin, V; Malouet, A C; Lelan, F; Dey, N D; Michel-Monigadon, D; Lu, M; Neveu, I; von Hörsten, S; Naveilhan, P; Dunbar, G L

    2012-01-01

    Treatments for neurodegenerative diseases have little impact on the long-term patient health. However, cellular transplants of neuroblasts derived from the aborted embryonic brain tissue in animal models of neurodegenerative disorders and in patients have demonstrated survival and functionality in the brain. However, ethical and functional problems due to the use of this fetal tissue stopped most of the clinical trials. Therefore, new cell sources were needed, and scientists focused on neural (NSCs) and mesenchymal stem cells (MSCs). When transplanted in the brain of animals with Parkinson's or Huntington's disease, NSCs and MSCs were able to induce partial functional recovery by promoting neuroprotection and immunomodulation. MSCs are more readily accessible than NSCs due to sources such as the bone marrow. However, MSCs are not capable of differentiating into neurons in vivo where NSCs are. Thus, transplantation of NSCs and MSCs is interesting for brain regenerative medicine. In this chapter, we detail the methods for NSCs and MSCs isolation as well as the transplantation procedures used to treat rodent models of neurodegenerative damage.

  4. Seasat data utilization project

    NASA Technical Reports Server (NTRS)

    Born, G. H.; Held, D. N.; Lame, D. B.; Lipes, R. G.; Montgomery, D. R.; Rygh, P. J.; Scott, J. F.

    1981-01-01

    During the three months of orbital operations, the satellite returned data from the world's oceans. Dozens of tropical storms, hurricanes and typhoons were observed, and two planned major intensive surface truth experiments were conducted. The utility of the Seasat-A microwave sensors as oceanographic tools was determined. Sensor and geophysical evaluations are discussed, including surface observations, and evaluation summaries of an altimeter, a scatterometer, a scanning multichannel microwave radiometer, a synthetic aperture radar, and a visible and infrared radiometer.

  5. Patterns of ambulatory medical care utilization in elderly patients with special reference to chronic diseases and multimorbidity - Results from a claims data based observational study in Germany

    PubMed Central

    2011-01-01

    Background In order to estimate the future demands for health services, the analysis of current utilization patterns of the elderly is crucial. The aim of this study is to analyze ambulatory medical care utilization by elderly patients in relation to age, gender, number of chronic conditions, patterns of multimorbidity, and nursing dependency in Germany. Methods Claims data of the year 2004 from 123,224 patients aged 65 years and over which are members of one nationwide operating statutory insurance company in Germany were studied. Multimorbidity was defined as the presence of 3 or more chronic conditions of a list of 46 most prevalent chronic conditions based on ICD 10 diagnoses. Utilization was analyzed by the number of contacts with practices of physicians working in the ambulatory medical care sector and by the number of different physicians contacted for every single chronic condition and their most frequent triadic combinations. Main statistical analyses were multidimensional frequency counts with standard deviations and confidence intervals, and multivariable linear regression analyses. Results Multimorbid patients had more than twice as many contacts per year with physicians than those without multimorbidity (36 vs. 16). These contact frequencies were associated with visits to 5.7 different physicians per year in case of multimorbidity vs. 3.5 when multimorbidity was not present. The number of contacts and of physicians contacted increased steadily with the number of chronic conditions. The number of contacts varied between 35 and 54 per year and the number of contacted physicians varied between 5 to 7, depending on the presence of individual chronic diseases and/or their triadic combinations. The influence of gender or age on utilization was small and clinically almost irrelevant. The most important factor influencing physician contact was the presence of nursing dependency due to disability. Conclusion In absolute terms, we found a very high rate of

  6. Age- and Sex-related Prevalence and Drug Utilization Pattern in the Management of Type 2 Diabetes Mellitus and its Comorbidity with Cardiovascular Diseases: A Comparative Study.

    PubMed

    Das, S; Haroled Peter, P L; Bhavani, M Lakshmi; Naresh, P; Ramana, M V

    2015-01-01

    A cross-sectional study of 250 cases of type 2 diabetes management was conducted in a governmental tertiary care hospital of urban south India to determine the comparative prevalence of type 2 diabetes and its comorbidity with cardiovascular diseases in diabetic population, core drug use indicators and drug utilization pattern in the management of diabetics entirely and with cardiovascular diseases. Highest prevalent age group for type 2 diabetes/cardiovascular diseases (greater incidence in female than male) was 51-60 years. The 62.8% prevalence of cardiovascular diseases in the diabetic population ascertained in the study could provide an evidence-based rationale for the World Health Organization guidelines for the management of hypertension in type 2 diabetics. Incidence of polypharmacy (6.06, the mean number of total drug products prescribed); 59.26% of encounters prescribed antibiotics; 17.6 and 18.5 min of average consultation and dispensing time, respectively; 100% of drugs actually dispensed and adequately labeled; 81.26% of patients having knowledge of correct dosage and average drug cost of Indian Rupees 145.54 per prescription were the core drug use indicators found mainly. Moreover, drugs prescribed from the Essential Drug List were more than 90% and thereby indicated the drug use in this set-up quite rational. Around 71.09% of cardiovascular agents prescribed by generic name revealed the cost effective medical care. Among the agents in type 2 diabetes management, Actrapid(®) (35.43%) was the highest. Among the cardiovascular agents prescribed, lasix (19.37%) was the highest. Cardiovascular agents prescribed orally by 76.48% signified the good prescription habit indicating the improved patients' adherence to the treatment. The present study emphasizes the need of early detection of hypertension as a preliminary diagnostic parameter of cardiovascular diseases in diabetics and appropriate management through concomitant therapy of cardiovascular drugs to

  7. Age- and Sex-related Prevalence and Drug Utilization Pattern in the Management of Type 2 Diabetes Mellitus and its Comorbidity with Cardiovascular Diseases: A Comparative Study.

    PubMed

    Das, S; Haroled Peter, P L; Bhavani, M Lakshmi; Naresh, P; Ramana, M V

    2015-01-01

    A cross-sectional study of 250 cases of type 2 diabetes management was conducted in a governmental tertiary care hospital of urban south India to determine the comparative prevalence of type 2 diabetes and its comorbidity with cardiovascular diseases in diabetic population, core drug use indicators and drug utilization pattern in the management of diabetics entirely and with cardiovascular diseases. Highest prevalent age group for type 2 diabetes/cardiovascular diseases (greater incidence in female than male) was 51-60 years. The 62.8% prevalence of cardiovascular diseases in the diabetic population ascertained in the study could provide an evidence-based rationale for the World Health Organization guidelines for the management of hypertension in type 2 diabetics. Incidence of polypharmacy (6.06, the mean number of total drug products prescribed); 59.26% of encounters prescribed antibiotics; 17.6 and 18.5 min of average consultation and dispensing time, respectively; 100% of drugs actually dispensed and adequately labeled; 81.26% of patients having knowledge of correct dosage and average drug cost of Indian Rupees 145.54 per prescription were the core drug use indicators found mainly. Moreover, drugs prescribed from the Essential Drug List were more than 90% and thereby indicated the drug use in this set-up quite rational. Around 71.09% of cardiovascular agents prescribed by generic name revealed the cost effective medical care. Among the agents in type 2 diabetes management, Actrapid(®) (35.43%) was the highest. Among the cardiovascular agents prescribed, lasix (19.37%) was the highest. Cardiovascular agents prescribed orally by 76.48% signified the good prescription habit indicating the improved patients' adherence to the treatment. The present study emphasizes the need of early detection of hypertension as a preliminary diagnostic parameter of cardiovascular diseases in diabetics and appropriate management through concomitant therapy of cardiovascular drugs to

  8. Diagnostic utility of CSF α-synuclein species in Parkinson's disease: protocol for a systematic review and meta-analysis

    PubMed Central

    Eusebi, Paolo; Giannandrea, David; Biscetti, Leonardo; Abraha, Iosief; Chiasserini, Davide; Orso, Massimiliano; Calabresi, Paolo; Parnetti, Lucilla

    2016-01-01

    Introduction The diagnostic criteria currently used for Parkinson's disease (PD) are mainly based on clinical motor symptoms. For these reasons many biomarkers are under investigation to support the diagnosis at the early stage. The neuropathological hallmark of PD is represented by Lewy bodies (LBs), which are intracytoplasmic inclusions in substantia nigra neurons. The major component of LBs, α-synuclein (α-syn), has been implicated in the pathogenesis of PD and in other ‘synucleinopathies’ such as multisystem atrophy (MSA) and dementia with LBs (DLBs). Several studies have investigated this presynaptic protein as a potential biomarker of PD. The aim of our meta-analysis is to determine the ability of cerebrospinal fluid (CSF) concentrations of total α-syn, oligomeric α-syn and phosphorylated α-syn to discriminate patients with PD from healthy participants, non-degenerative neurological controls and patients suffering from parkinsonism and or synucleinopathies. Methods and analysis This systematic review protocol has been developed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocol (PRISMA-P) 2015 statement and was registered on PROSPERO (CRD42016013217). We will search Cochrane Library, Web of Science, MEDLINE (via PubMed) and EMBASE from inception, using appropriate search strategies. Two independent reviewers will screen titles, abstracts and full-text articles, and will complete data abstraction. We will include studies that involved patients with PD, DLB, MSA, progressive supranuclear palsy, corticobasal disease and vascular PD, and in which at least one between total α-syn, oligomeric α-syn and phosphorylated α-syn was measured in CSF. To evaluate the risk of bias and applicability of primary diagnostic accuracy studies, we will use QUADAS-2. Ethics and dissemination Our study will not include confidential data, and no intervention will be involved, so ethical approval is not required. The results of the

  9. The epidemiology and burden of Alzheimer’s disease in Taiwan utilizing data from the National Health Insurance Research Database

    PubMed Central

    Hung, Yen-Ni; Kadziola, Zbigniew; Brnabic, Alan JM; Yeh, Ju-Fen; Fuh, Jong-Ling; Hwang, Jen-Ping; Montgomery, William

    2016-01-01

    Purpose The objectives of this study were to estimate the incidence, cumulative incidence, and economic burden of Alzheimer’s disease (AD) in Taiwan, using data from the National Health Insurance Research Database (NHIRD). Materials and methods This was a retrospective, longitudinal, observational study using data from the Longitudinal Health Insurance Database of the NHIRD. Patients were included in this study if they were 50 years of age or older and their records included a primary or secondary diagnosis of AD. New patients who met inclusion criteria were followed up longitudinally from 2005 to 2010. Costs were calculated for the first year following the diagnosis of AD. Results Overall, a higher percentage of women than men were diagnosed with AD (54% vs 46%, respectively). The first AD diagnosis occurred most frequently in the age of 75–84 years. The person-year incidence rate increased from 5.63/1,000 persons (95% CI, 5.32–5.94) in 2005 to 8.17/1,000 persons (95% CI, 7.78–8.57) in 2010. The cumulative incidence rate was 33.54/1,000 persons (95% CI, 32.76–34.33) in 2005–2010. The total mean inflated annual costs per patient in new Taiwan dollars (NT$) in the first year of diagnosis ranged from NT$205,413 (2009) to NT$227,110 (2005), with hospitalization representing the largest component. Conclusion AD represents a substantial burden in Taiwan, and based on the observed increase in incidence rate over time, it is likely that this burden will continue to increase. The findings reported here are consistent with previous research. The NHIRD contains extensive real-world information that can be used to conduct research, allowing us to expand our understanding of the incidence, prevalence, and burden of disease in Taiwan. PMID:27536149

  10. Using Cell Phones From Satellites

    NASA Technical Reports Server (NTRS)

    Horan, Stephen

    2000-01-01

    During the past several years, an interest has grown in using commercial telecommunications techniques to supply Telemetry and Command (T&C) services. Recently, the National Aeronautics and Space Administration (NASA) Space Operations Management Office (SOMO) has outlined plans to utilize satellite-based telecommunications services to support space operations in space missions over the next several decades. NASA currently obtains the bulk of its telecommunications services for earth-orbiting satellites via the existing government-owned and controlled Space Network (SN) system. This system consists of the constellation of Tracking and Data Relay Satellites (TDRS) in Geostationary Earth Orbit (GEO) and the associated ground terminals and communications intrastructure. This system is valuable and effective for scientific satellites costing over one million dollars. However, for smaller satellites, this system becomes problematic due to the cost of transponders and support infrastructure. The nominal transponders for using the TDRS cannot be obtained for a cost in dollars, and size, weight, or power that the 3 Corner Satellite project can afford. For these types of nanosatellite missions, alternatives that fit the mission cost and satellite profiles are needed. In particular, low-cost access using existing commercial infrastructure would be useful to mission planners. In particular, the ability to obtain low data rate T&C services would be especially valuable. The nanosatellites generally have low T&C requirements and therefore would benefit from using commercial services that could operate in the 2400 bps - 9600 bps range, especially if contact times longer than the 5 - 10 minute ground station passes could be found.

  11. Dust collection on serviceable satellites

    NASA Technical Reports Server (NTRS)

    Nuth, J. A., III

    1986-01-01

    One rationale for the Space Shuttle program which was dramatically realized during the repair of the Solar Maximum Mission (SMM) is the efficiency of in-orbit satellite servicing. An unexpected benefit of this repair mission was the return of parts of the Solar Max satellite which had been exposed for four years to the space environment. Studies conducted on these parts have yielded valuable data on the micrometeorite flux and composition at shuttle altitudes during this time period. The scientific results from studies of the cosmic dust component of the observed particle impacts are not yet complete but it is clear from the preliminary data available that such studies will be a valuable adjunct to the studies of cosmic dust particles collected in the atmosphere. The success of the initial studies of particles collected during repairs of the SMM spacecraft on a surface not specifically designed as a particle collector nor retrieved in a manner intended to minimize or eliminate local contamination raises the possibility that even more interesting results might be obtained if serviceable satellites were initially designed with these objectives in mind. All designs for modern satellites utilize some form of thermal blanket material in order to minimize thermal stresses inside the spacecraft. It is proposed that all future satellites be designed with standardized removeable sections of thermal blanket material which could be replaced during on-orbit servicing and returned to earth for detailed study.

  12. Low Earth orbit communications satellite

    NASA Technical Reports Server (NTRS)

    Moroney, D.; Lashbrook, D.; Mckibben, B.; Gardener, N.; Rivers, T.; Nottingham, G.; Golden, B.; Barfield, B.; Bruening, J.; Wood, D.

    1992-01-01

    A current thrust in satellite communication systems considers a low-Earth orbiting constellations of satellites for continuous global coverage. Conceptual design studies have been done at the time of this design project by LORAL Aerospace Corporation under the program name GLOBALSTAR and by Motorola under their IRIDIUM program. This design project concentrates on the spacecraft design of the GLOBALSTAR low-Earth orbiting communication system. Overview information on the program was gained through the Federal Communications Commission licensing request. The GLOBALSTAR system consists of 48 operational satellites positioned in a Walker Delta pattern providing global coverage and redundancy. The operational orbit is 1389 km (750 nmi) altitude with eight planes of six satellites each. The orbital planes are spaced 45 deg., and the spacecraft are separated by 60 deg. within the plane. A Delta 2 launch vehicle is used to carry six spacecraft for orbit establishment. Once in orbit, the spacecraft will utilize code-division multiple access (spread spectrum modulation) for digital relay, voice, and radio determination satellite services (RDSS) yielding position determination with accuracy up to 200 meters.

  13. Nano-Satellite Avionics

    NASA Technical Reports Server (NTRS)

    Culver, Harry

    1999-01-01

    Abstract NASA's Goddard Space Flight Center (GSFC) is currently developing a new class of satellites called the nano-satellite (nano-sat). A major objective of this development effort is to provide the technology required to enable a constellation of tens to hundreds of nano-satellites to make both remote and in-situ measurements from space. The Nano-sat will be a spacecraft weighing a maximum of 10 kg, including the propellant mass, and producing at least 5 Watts of power to operate the spacecraft. The electronics are required to survive a total radiation dose rate of 100 krads for a mission lifetime of two years. There are many unique challenges that must be met in order to develop the avionics for such a spacecraft. The first challenge is to develop an architecture that will operate on the allotted 5 Watts and meet the diverging requirements of multiple missions. This architecture will need to incorporate a multitude of new advanced microelectronic technologies. The microelectronics developed must be a modular and scalable packaging of technology to solve the problem of developing a solution to both reduce cost and meet the requirements of various missions. This development will utilize the most cost effective approach, whether infusing commercially driven semiconductor devices into spacecraft applications or partnering with industry to design and develop low cost, low power, low mass, and high capacity data processing devices. This paper will discuss the nano-sat architecture and the major technologies that will be developed. The major technologies that will be covered include: (1) Light weight Low Power Electronics Packaging, (2) Radiation Hard/Tolerant, Low Power Processing Platforms, (3) High capacity Low Power Memory Systems (4) Radiation Hard reconfiguragble field programmable gate array (rFPGA)

  14. Screening for Cognitive Impairment in Parkinson's Disease: Improving the Diagnostic Utility of the MoCA through Subtest Weighting

    PubMed Central

    Fengler, Sophie; Kessler, Josef; Timmermann, Lars; Zapf, Alexandra; Elben, Saskia; Wojtecki, Lars; Tucha, Oliver; Kalbe, Elke

    2016-01-01

    Background Given the high prevalence of cognitive impairment in Parkinson’s disease (PD), cognitive screening is important in clinical practice. The Montreal Cognitive Assessment (MoCA) is a frequently used screening test in PD to detect mild cognitive impairment (PD-MCI) and Parkinson’s disease dementia (PD-D). However, the proportion in which the subtests are represented in the MoCA total score does not seem reasonable. We present the development and preliminary evaluation of an empirically based alternative scoring system of the MoCA which aims at increasing the overall diagnostic accuracy. Methods In study 1, the MoCA was administered to 40 patients with PD without cognitive impairment (PD-N), PD-MCI, or PD-D, as defined by a comprehensive neuropsychological test battery. The new MoCA scoring algorithm was developed by defining Areas under the Curve (AUC) for MoCA subtests in a Receiver Operating Characteristic (ROC) and by weighting the subtests according to their sensitivities and specificities. In study 2, an independent sample of 24 PD patients (PD-N, PD-MCI, or PD-D) was tested with the MoCA. In both studies, diagnostic accuracy of the original and the new scoring procedure was calculated. Results Diagnostic accuracy increased with the new MoCA scoring algorithm. In study 1, the sensitivity to detect cognitive impairment increased from 62.5% to 92%, while specificity decreased only slightly from 77.7% to 73%; in study 2, sensitivity increased from 68.8% to 81.3%, while specificity stayed stable at 75%. Conclusion This pilot study demonstrates that the sensitivity of the MoCA can be enhanced substantially by an empirically based weighting procedure and that the proposed scoring algorithm may serve the MoCA’s actual purpose as a screening tool in the detection of cognitive dysfunction in PD patients better than the original scoring of the MoCA. Further research with larger sample sizes is necessary to establish efficacy of the alternate scoring system

  15. Evaluation of the diagnostic and prognostic utility of ultrasonography at first diagnosis of presumptive bovine respiratory disease

    PubMed Central

    Abutarbush, Sameeh M.; Pollock, Colleen M.; Wildman, Brian K.; Perrett, Tye; Schunicht, Oliver C.; Fenton, R. Kent; Hannon, Sherry J.; Vogstad, Amanda R.; Jim, G. Kee; Booker, Calvin W.

    2012-01-01

    This project investigated the use of ultrasonography at first diagnosis of presumptive early bovine respiratory disease (BRD) in feedlot cattle from western Canada. One hundred seventy-four cattle (116 cases and 58 controls) at high risk of developing BRD were enrolled in a prospective longitudinal study over 2 y (2006–2007). Cattle with clinical signs relating to the respiratory system and assessed as sick at the time of feedlot arrival (arrival fever cases) or assessed as sick in the pen 3 to 30 d post-arrival (post-arrival fever cases, post-arrival no fevers cases) were eligible for enrollment. Control animals were identified at the time of case enrollments. Ultrasonography was done using a 3.5 sector transducer at enrollment and at 2, 4, and 6 wk post-enrollment. Lung lesions were identified at least 1 time over the course of the trial in 32/116 (28%) cases and 9/58 (16%) controls. At enrollment, lung lesions were identified in 20/115 (17%) cases and 2/55 (4%) controls (data unreadable n = 4). Post-arrival fever cases (14/48) were the most likely to have a lesion identified using ultrasound. In arrival fever cases, average daily gain (enrollment to last ultrasound, average 34 d) was improved (P = 0.007) in cattle identified with a lesion at enrollment using ultrasound compared with those not identified with a lesion at that time, potentially demonstrating the effects of gut fill at arrival weighing, as these sicker animals may have eaten less prior to arrival and, therefore, had more room for improvement in weight over time due to restoration of normal gut fill. None of the ultrasound time points explored (enrollment, 2, 4, or 6 wk post-enrollment) were associated with the animal health outcomes of interest (subsequent treatment, chronicity, wastage, or mortality) for cattle enrolled at arrival or post-arrival. Ultrasonography using a 3.5 sector transducer was not particularly effective as a prognostic/diagnostic tool for early detection of BRD, but may be

  16. Shadow imaging of geosynchronous satellites

    NASA Astrophysics Data System (ADS)

    Douglas, Dennis Michael

    Geosynchronous (GEO) satellites are essential for modern communication networks. If communication to a GEO satellite is lost and a malfunction occurs upon orbit insertion such as a solar panel not deploying there is no direct way to observe it from Earth. Due to the GEO orbit distance of ~36,000 km from Earth's surface, the Rayleigh criteria dictates that a 14 m telescope is required to conventionally image a satellite with spatial resolution down to 1 m using visible light. Furthermore, a telescope larger than 30 m is required under ideal conditions to obtain spatial resolution down to 0.4 m. This dissertation evaluates a method for obtaining high spatial resolution images of GEO satellites from an Earth based system by measuring the irradiance distribution on the ground resulting from the occultation of the satellite passing in front of a star. The representative size of a GEO satellite combined with the orbital distance results in the ground shadow being consistent with a Fresnel diffraction pattern when observed at visible wavelengths. A measurement of the ground shadow irradiance is used as an amplitude constraint in a Gerchberg-Saxton phase retrieval algorithm that produces a reconstruction of the satellite's 2D transmission function which is analogous to a reverse contrast image of the satellite. The advantage of shadow imaging is that a terrestrial based redundant set of linearly distributed inexpensive small telescopes, each coupled to high speed detectors, is a more effective resolved imaging system for GEO satellites than a very large telescope under ideal conditions. Modeling and simulation efforts indicate sub-meter spatial resolution can be readily achieved using collection apertures of less than 1 meter in diameter. A mathematical basis is established for the treatment of the physical phenomena involved in the shadow imaging process. This includes the source star brightness and angular extent, and the diffraction of starlight from the satellite

  17. Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson's Diseases sample.

    PubMed

    Scarpina, Federica; Ambiel, Erika; Albani, Giovanni; Pradotto, Luca Guglielmo; Mauro, Alessandro

    2016-10-01

    This study examined the ability of the Boston Qualitative Scoring System (BQSS) in comparison to the Osterrieth scoring method to separate Parkinson's Disease patients without dementia from healthy controls at the Rey-Osterrieth Complex Figure (ROCF) copy. 30 PD participants and 30 healthy participants completed ROCF copy. The performance was scored according to both methods. The results indicated that PD patients performed significantly worse on ROCF. According to ROC analyses, BQSS Copy Total score represented the most suitable index to distinguish between the two groups: a score below or equal to 16 indicates an impaired performance. Moreover, PD participants reported lower performance in the BQSS scores of Planning and Neatness. PD patients' poor performance in ROCF copy was related to executive difficulties, specifically in terms of planning and impulsivity, instead of global visuo-constructional impairments. An extensive evaluation of copy drawings allowing to disentangle between different involved cognitive domains would be suitable, specifically in those clinical conditions like PD, in which motor impairments affect drawing performance.

  18. Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note

    PubMed Central

    Falsey, Ann R; Becker, Kenneth L; Swinburne, Andrew J; Nylen, Eric S; Snider, Richard H; Formica, Maria A; Hennessey, Patricia A; Criddle, Mary M; Peterson, Derick R; Walsh, Edward E

    2012-01-01

    Background Serum procalcitonin levels have been used as a biomarker of invasive bacterial infection and recently have been advocated to guide antibiotic therapy in patients with chronic obstructive pulmonary disease (COPD). However, rigorous studies correlating procalcitonin levels with microbiologic data are lacking. Acute exacerbations of COPD (AECOPD) have been linked to viral and bacterial infection as well as noninfectious causes. Therefore, we evaluated procalcitonin as a predictor of viral versus bacterial infection in patients hospitalized with AECOPD with and without evidence of pneumonia. Methods Adults hospitalized during the winter with symptoms consistent with AECOPD underwent extensive testing for viral, bacterial, and atypical pathogens. Serum procalcitonin levels were measured on day 1 (admission), day 2, and at one month. Clinical and laboratory features of subjects with viral and bacterial diagnoses were compared. Results In total, 224 subjects with COPD were admitted for 240 respiratory illnesses. Of these, 56 had pneumonia and 184 had AECOPD alone. A microbiologic diagnosis was made in 76 (56%) of 134 illnesses with reliable bacteriology (26 viral infection, 29 bacterial infection, and 21 mixed viral bacterial infection). Mean procalcitonin levels were significantly higher in patients with pneumonia compared with AECOPD. However, discrimination between viral and bacterial infection using a 0.25 ng/mL threshold for bacterial infection in patients with AECOPD was poor. Conclusion Procalcitonin is useful in COPD patients for alerting clinicians to invasive bacterial infections such as pneumonia but it does not distinguish bacterial from viral and noninfectious causes of AECOPD. PMID:22399852

  19. Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson's Diseases sample.

    PubMed

    Scarpina, Federica; Ambiel, Erika; Albani, Giovanni; Pradotto, Luca Guglielmo; Mauro, Alessandro

    2016-10-01

    This study examined the ability of the Boston Qualitative Scoring System (BQSS) in comparison to the Osterrieth scoring method to separate Parkinson's Disease patients without dementia from healthy controls at the Rey-Osterrieth Complex Figure (ROCF) copy. 30 PD participants and 30 healthy participants completed ROCF copy. The performance was scored according to both methods. The results indicated that PD patients performed significantly worse on ROCF. According to ROC analyses, BQSS Copy Total score represented the most suitable index to distinguish between the two groups: a score below or equal to 16 indicates an impaired performance. Moreover, PD participants reported lower performance in the BQSS scores of Planning and Neatness. PD patients' poor performance in ROCF copy was related to executive difficulties, specifically in terms of planning and impulsivity, instead of global visuo-constructional impairments. An extensive evaluation of copy drawings allowing to disentangle between different involved cognitive domains would be suitable, specifically in those clinical conditions like PD, in which motor impairments affect drawing performance. PMID:27299429

  20. Utility of a Pediatric Bleeding Questionnaire as a Screening Tool for von Willebrand Disease in Apparently Healthy Children

    PubMed Central

    Mittal, Nupur; Pedersen, Rachelle; James, Paula; Shott, Susan; Valentino, Leonard A.

    2015-01-01

    von Willebrand disease (VWD), an inherited bleeding disorder caused by deficiency or dysfunction of von Willebrand factor (VWF) is diagnosed when a personal and often a family history of excessive mucocutaneous bleeding is present along with abnormal laboratory studies. An accurate assessment of hemorrhagic symptoms is key in suspecting VWD but presents a challenge especially in children due to overlap between normal and abnormal bleeding. Bleeding questionnaire (BQ) scores have been validated in adults and have recently been validated in children with VWD for assessing bleeding severity. However there is limited data supporting their use prospectively in healthy children with bleeding complaints. The objectives of this study were to obtain normative data from children and validate a pediatric BQ to determine the discriminative ability of its total score and its individual components for identifying children likely to have VWD. Methods The pediatric BQ was administered to 1281 multiethnic, healthy children between 30 days and 18 years of age presenting to a general pediatric office and to 35 children with VWD based on VWF antigen, activity and multimer pattern. Results When children with total BQ scores of 3 or more were predicted to have VWD, the sensitivity was 97.2%, the specificity was 97.1%, the positive predictive value was 48.6%, and the negative predictive value was 99.9%. Conclusions The pediatric BQ may help discriminate a significant bleeding history from otherwise trivial bleeding and may be integrated into the primary care algorithm for evaluating children suspected of having VWD. PMID:25982122

  1. Utilizing Nontraditional Data Sources for Near Real-Time Estimation of Transmission Dynamics During the 2015-2016 Colombian Zika Virus Disease Outbreak

    PubMed Central

    Santillana, Mauricio; Mekaru, Sumiko R; McGinnis, Denise P; Khan, Kamran; Brownstein, John S

    2016-01-01

    Background Approximately 40 countries in Central and South America have experienced local vector-born transmission of Zika virus, resulting in nearly 300,000 total reported cases of Zika virus disease to date. Of the cases that have sought care thus far in the region, more than 70,000 have been reported out of Colombia. Objective In this paper, we use nontraditional digital disease surveillance data via HealthMap and Google Trends to develop near real-time estimates for the basic (R0) and observed (Robs) reproductive numbers associated with Zika virus disease in Colombia. We then validate our results against traditional health care-based disease surveillance data. Methods Cumulative reported case counts of Zika virus disease in Colombia were acquired via the HealthMap digital disease surveillance system. Linear smoothing was conducted to adjust the shape of the HealthMap cumulative case curve using Google search data. Traditional surveillance data on Zika virus disease were obtained from weekly Instituto Nacional de Salud (INS) epidemiological bulletin publications. The Incidence Decay and Exponential Adjustment (IDEA) model was used to estimate R0 and Robs for both data sources. Results Using the digital (smoothed HealthMap) data, we estimated a mean R0 of 2.56 (range 1.42-3.83) and a mean Robs of 1.80 (range 1.42-2.30). The traditional (INS) data yielded a mean R0 of 4.82 (range 2.34-8.32) and a mean Robs of 2.34 (range 1.60-3.31). Conclusions Although modeling using the traditional (INS) data yielded higher R0 estimates than the digital (smoothed HealthMap) data, modeled ranges for Robs were comparable across both data sources. As a result, the narrow range of possible case projections generated by the traditional (INS) data was largely encompassed by the wider range produced by the digital (smoothed HealthMap) data. Thus, in the absence of traditional surveillance data, digital surveillance data can yield similar estimates for key transmission parameters and

  2. Iodine Satellite

    NASA Technical Reports Server (NTRS)

    Kamhawi, Hani; Dankanich, John; Martinez, Andres; Petro, Andrew

    2015-01-01

    The Iodine Satellite (iSat) spacecraft will be the first CubeSat to demonstrate high change in velocity from a primary propulsion system by using Hall thruster technology and iodine as a propellant. The mission will demonstrate CubeSat maneuverability, including plane change, altitude change and change in its closest approach to Earth to ensure atmospheric reentry in less than 90 days. The mission is planned for launch in fall 2017. Hall thruster technology is a type of electric propulsion. Electric propulsion uses electricity, typically from solar panels, to accelerate the propellant. Electric propulsion can accelerate propellant to 10 times higher velocities than traditional chemical propulsion systems, which significantly increases fuel efficiency. To enable the success of the propulsion subsystem, iSat will also demonstrate power management and thermal control capabilities well beyond the current state-of-the-art for spacecraft of its size. This technology is a viable primary propulsion system that can be used on small satellites ranging from about 22 pounds (10 kilograms) to more than 1,000 pounds (450 kilograms). iSat's fuel efficiency is ten times greater and its propulsion per volume is 100 times greater than current cold-gas systems and three times better than the same system operating on xenon. iSat's iodine propulsion system consists of a 200 watt (W) Hall thruster, a cathode, a tank to store solid iodine, a power processing unit (PPU) and the feed system to supply the iodine. This propulsion system is based on a 200 W Hall thruster developed by Busek Co. Inc., which was previously flown using xenon as the propellant. Several improvements have been made to the original system to include a compact PPU, targeting greater than 80 percent reduction in mass and volume of conventional PPU designs. The cathode technology is planned to enable heaterless cathode conditioning, significantly increasing total system efficiency. The feed system has been designed to

  3. The TOPEX satellite option study

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The applicability of an existing spacecraft bus and subsystems to the requirements of ocean circulation measurements are assessed. The operational meteorological satellite family TIROS and DMSP are recommended. These programs utilize a common bus to satisfy their Earth observation missions. Note that although the instrument complements were different, the pointing accuracies were different, and, initially, the boosters were different, a high degree of commonality was achieved.

  4. Cesium standard for satellite application

    NASA Technical Reports Server (NTRS)

    Bloch, M. B.; Meirs, M.; Pascaru, I.; Weinstein, B.

    1983-01-01

    A Cesium frequency standard that was developed for satellite applications is discussed. It weighs 23 lbs. and uses 23.5 watts of power, achieves a stability of 1 x ten to the minus 13th power/100,000 seconds, and is radiation hardened. To achieve the weight and reliability requirements, both thick and thin film hybrid circuits were utilized. A crystal oscillator is used to improve short-term stability and performance on a moving platform.

  5. Perceived Utility of the RE-AIM Framework for Health Promotion/Disease Prevention Initiatives for Older Adults: A Case Study from the U.S. Evidence-Based Disease Prevention Initiative

    PubMed Central

    Ory, Marcia G.; Altpeter, Mary; Belza, Basia; Helduser, Janet; Zhang, Chen; Smith, Matthew Lee

    2015-01-01

    Dissemination and implementation (D&I) frameworks are increasingly being promoted in public health research. However, less is known about their uptake in the field, especially for diverse sets of programs. Limited questionnaires exist to assess the ways that frameworks can be utilized in program planning and evaluation. We present a case study from the United States that describes the implementation of the RE-AIM framework by state aging services providers and public health partners and a questionnaire that can be used to assess the utility of such frameworks in practice. An online questionnaire was developed to capture community perspectives about the utility of the RE-AIM framework. Distributed to project leads in 27 funded states in an evidence-based disease prevention initiative for older adults, 40 key stakeholders responded representing a 100% state-participation rate among the 27 funded states. Findings suggest that there is perceived utility in using the RE-AIM framework when evaluating grand-scale initiatives for older adults. The RE-AIM framework was seen as useful for planning, implementation, and evaluation with relevance for evaluators, providers, community leaders, and policy makers. Yet, the uptake was not universal, and some respondents reported difficulties in use, especially adopting the framework as a whole. This questionnaire can serve as the basis to assess ways the RE-AIM framework can be utilized by practitioners in state-wide D&I efforts. Maximal benefit can be derived from examining the assessment of RE-AIM-related knowledge and confidence as part of a continual quality assurance process. We recommend such an assessment be performed before the implementation of new funding initiatives and throughout their course to assess RE-AIM uptake and to identify areas for technical assistance. PMID:25964897

  6. Navy satellite communications

    NASA Astrophysics Data System (ADS)

    Clair, William C.

    1992-03-01

    The history, current status, and future plans of Navy satellite communications are reviewed. Particular attention is given to Fleet Satellites; the Defense Satellite Communications System; the International Maritime Satellite; Core Command and Control (Core C2), General Purpose Communications, and Navy EHF SATCOM program; and the Copernicus architecture.

  7. Tethered Communication Satellites

    NASA Technical Reports Server (NTRS)

    Von Tiesenhausen, G.

    1986-01-01

    Report describes concept for placing several communication satellites in geostationary orbit without taking up more space than assigned to single satellite. Proposed scheme eases orbital crowding more economically than space platforms. Concept requires minimal redesign of existing satellites and accommodates many satellites in just one orbital slot. System much lighter in weight than geostationary platform and easier and more economical to transport.

  8. Utility of behavioral versus cognitive measures in differentiating between subtypes of frontotemporal lobar degeneration and Alzheimer's disease.

    PubMed

    Heidler-Gary, Jennifer; Gottesman, Rebecca; Newhart, Melissa; Chang, Shannon; Ken, Lynda; Hillis, Argye E

    2007-01-01

    We hypothesized that a modified version of the Frontal Behavioral Inventory (FBI-mod), along with a few cognitive tests, would be clinically useful in distinguishing between clinically defined Alzheimer's disease (AD) and subtypes of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (dysexecutive type), progressive nonfluent aphasia, and semantic dementia. We studied 80 patients who were diagnosed with AD (n = 30) or FTLD (n = 50), on the basis of a comprehensive neuropsychological battery, imaging, neurological examination, and history. We found significant between-group differences on the FBI-mod, two subtests of the Rey Auditory Verbal Learning Test (verbal learning and delayed recall), and the Trail Making Test Part B (one measure of 'executive functioning'). AD was characterized by relatively severe impairment in verbal learning, delayed recall, and executive functioning, with relatively normal scores on the FBI-mod. Frontotemporal dementia was characterized by relatively severe impairment on the FBI-mod and executive functioning in the absence of severe impairment in verbal learning and recall. Progressive nonfluent aphasia was characterized by severe impairment in executive functioning with relatively normal scores on verbal learning and recall and FBI-mod. Finally, semantic dementia was characterized by relatively severe deficits in delayed recall, but relatively normal performance on new learning, executive functioning, and on FBI-mod. Discriminant function analysis confirmed that the FBI-mod, in conjunction with the Rey Auditory Verbal Learning Test, and the Trail Making Test Part B categorized the majority of patients as subtypes of FTLD or AD in the same way as a full neuropsychological battery, neurological examination, complete history, and imaging. These tests may be useful for efficient clinical diagnosis, although progressive nonfluent aphasia and semantic dementia are likely to be best distinguished by language tests not included

  9. Genetic diagnosis of autosomal dominant polycystic kidney disease by targeted capture and next-generation sequencing: utility and limitations.

    PubMed

    Qi, Xiao-Ping; Du, Zhen-Fang; Ma, Ju-Ming; Chen, Xiao-Ling; Zhang, Qing; Fei, Jun; Wei, Xiao-Ming; Chen, Dong; Ke, Hai-Ping; Liu, Xuan-Zhu; Li, Feng; Chen, Zhen-Guang; Su, Zheng; Jin, Hang-Yang; Liu, Wen-Ting; Zhao, Yan; Jiang, Hu-Ling; Lan, Zhang-Zhang; Li, Peng-Fei; Fang, Ming-Yan; Dong, Wei; Zhang, Xian-Ning

    2013-03-01

    Mutation-based molecular diagnostics of autosomal dominant polycystic kidney disease (ADPKD) is complicated by genetic and allelic heterogeneity, large multi-exon genes, and duplication sequences of PKD1. Recently, targeted resequencing by pooling long-range polymerase chain reaction (LR-PCR) amplicons has been used in the identification of mutations in ADPKD. Despite its high sensitivity, specificity and accuracy, LR-PCR is still complicated. We performed whole-exome sequencing on two unrelated typical Chinese ADPKD probands and evaluated the effectiveness of this approach compared with Sanger sequencing. Meanwhile, we performed targeted gene and next-generation sequencing (targeted DNA-HiSeq) on 8 individuals (1 patient from one family, 5 patients and 2 normal individuals from another family). Both whole-exome sequencing and targeted DNA-HiSeq confirmed c.11364delC (p.H3788QfsX37) within the unduplicated region of PKD1 in one proband; in the other family, targeted DNA-HiSeq identified a small insertion, c.401_402insG (p.V134VfsX79), in PKD2. These methods do not overcome the screening complexity of homology. However, the true positives of variants confirmed by targeted gene and next-generation sequencing were 69.4%, 50% and 100% without a false positive in the whole coding region and the duplicated and unduplicated regions, which indicated that the screening accuracy of PKD1 and PKD2 can be largely improved by using a greater sequencing depth and elaborate design of the capture probe.

  10. The need for wider and appropriate utilization of aspirin and statins in the treatment and prevention of cardiovascular disease.

    PubMed

    Hennekens, Charles H; Schneider, Wendy R

    2008-01-01

    There is an increasing burden of occlusive cardiovascular disease (CVD) in developed, as well as in developing, countries. In fact, the WHO has projected that CVD will become the leading cause of death in the world in the next 10 years. The proximate cause of virtually all occlusive vascular events is thrombosis and the principal underlying cause is atherosclerosis. Aspirin, which inhibits platelet-dependent cyclooxygenase for the entire life of the platelet, has clinically important antithrombotic effects. Statins, which principally decrease low-density lipoprotein cholesterol, triglycerides and increase high-density lipoprotein cholesterol, have clinically important antiatherogenic effects. In secondary prevention, in a wide range of patients who have survived a prior myocardial infarction (MI), occlusive stroke, transient ischemic attack, as well as other high-risk conditions, long-term use of aspirin confers statistically significant and clinically important reductions in MI, stroke and CVD death. In addition, aspirin confers similar benefits when administered during acute MI or acute occlusive stroke. In primary prevention, aspirin confers a statistically significant and clinically important reduction in risk of a first MI but the data on stroke and CVD death remain inconclusive, so aspirin should be prescribed on an individual basis by the healthcare provider who weighs this clear benefit against long-term side effects. In a meta-analysis of 14 randomized trials of 90,056 subjects treated for 5 years, statins confer statistically significant and clinically important reductions in MI, stroke, CVD death and total mortality. In a meta-analysis of randomized trials of statins, in which aspirin was used in varying frequencies, the combination of aspirin and statins conferred greater clinical benefits than either agent alone on MI, occlusive stroke and CVD death. At present, the wider and more appropriate use of aspirin and statins will reduce premature MI, stroke

  11. Advanced satellite communication system

    NASA Technical Reports Server (NTRS)

    Staples, Edward J.; Lie, Sen

    1992-01-01

    The objective of this research program was to develop an innovative advanced satellite receiver/demodulator utilizing surface acoustic wave (SAW) chirp transform processor and coherent BPSK demodulation. The algorithm of this SAW chirp Fourier transformer is of the Convolve - Multiply - Convolve (CMC) type, utilizing off-the-shelf reflective array compressor (RAC) chirp filters. This satellite receiver, if fully developed, was intended to be used as an on-board multichannel communications repeater. The Advanced Communications Receiver consists of four units: (1) CMC processor, (2) single sideband modulator, (3) demodulator, and (4) chirp waveform generator and individual channel processors. The input signal is composed of multiple user transmission frequencies operating independently from remotely located ground terminals. This signal is Fourier transformed by the CMC Processor into a unique time slot for each user frequency. The CMC processor is driven by a waveform generator through a single sideband (SSB) modulator. The output of the coherent demodulator is composed of positive and negative pulses, which are the envelopes of the chirp transform processor output. These pulses correspond to the data symbols. Following the demodulator, a logic circuit reconstructs the pulses into data, which are subsequently differentially decoded to form the transmitted data. The coherent demodulation and detection of BPSK signals derived from a CMC chirp transform processor were experimentally demonstrated and bit error rate (BER) testing was performed. To assess the feasibility of such advanced receiver, the results were compared with the theoretical analysis and plotted for an average BER as a function of signal-to-noise ratio. Another goal of this SBIR program was the development of a commercial product. The commercial product developed was an arbitrary waveform generator. The successful sales have begun with the delivery of the first arbitrary waveform generator.

  12. Low utilization of prenatal and pre-implantation genetic diagnosis in Huntington disease - risk discounting in preventive genetics.

    PubMed

    Schulman, J D; Stern, H J

    2015-09-01

    Huntington disease (HD) is a late-onset, fatal neurodegenerative disorder caused by a (CAG) triplet repeat expansion in the Huntingtin gene that enlarges during male meiosis. In 1996 in this journal, one of us (J. D. S.) presented a methodology to perform pre-implantation genetic diagnosis in families at-risk for HD without revealing the genetic status of the at-risk parent. Despite the introduction of accurate prenatal and pre-implantation genetic testing which can prevent transmission of the abnormal HD gene in the family permanently, utilization of these options is extremely low. In this article, we examine the decision-making process regarding genetic testing in families with HD and discuss the possible reasons for the low uptake among this group.

  13. Domestic satellite communications systems - Background and projections

    NASA Astrophysics Data System (ADS)

    Bargellini, P. L.

    Planned and existing national and international communications satellites are reviewed, along with comparative costs for leasing or owning a satellite and the basic capabilities of communications spacecraft. Eleven different satellite communications systems existed in 1982, including Intelsat, Marisat/Inmarsat, and Intersputnik as the international segments, and the Molniya, Telesat, Palapa, Westar, Satcom, Comstar, Amersat, and the SBS national systems. Seven of the twenty countries leasing Intelsat services are planning their own satellites. Leasing permits full capabilities withno development costs and ensures the lessor of full use of the satellite capacities. Developing countries can then gain hands-on experience with space technologies. Future demands are discussed, noting the broadening of the available bandwidths, better orbit utilization, and increases in transponder numbers to handle increased loads in future spacecraft.

  14. Satellite communications for disaster relief operations

    NASA Technical Reports Server (NTRS)

    Sivo, J. N.

    1979-01-01

    The use of existing and planned communication satellite systems to provide assistance in the implementation of disaster relief operations on a global basis was discussed along with satellite communications system implications and their potential impact on field operations in disaster situations. Consideration are given to the utilization of both INTELSAT and MARISAT systems operating at frequencies ranging from 1.5 to 4 GHz and to the size and type of ground terminals necessary for satellite access. Estimates of communication requirements for a global system are given. Some discussion of cost estimates for satellite services to support operations are included. Studies of communication satellites for both pre and post disaster applications conducted for NOAA are included as well as recent experiments conducted in conjunction with the Office of Foreign Disaster Assistance of the Agency for International Development.

  15. A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites.

    PubMed

    Reinholz, Monica M; Zinnen, Shawn P; Dueck, Amylou C; Dingli, David; Reinholz, Gregory G; Jonart, Leslie A; Kitzmann, Kathleen A; Bruzek, Amy K; Negron, Vivian; Abdalla, Abdalla K; Arendt, Bonnie K; Croatt, Anthony J; Sanchez-Perez, Luis; Sebesta, David P; Lönnberg, Harri; Yoneda, Toshiyuki; Nath, Karl A; Jelinek, Diane F; Russell, Stephen J; Ingle, James N; Spelsberg, Thomas C; Dixon, Henry B F Hal; Karpeisky, Alexander; Lingle, Wilma L

    2010-07-01

    Despite palliative treatments, tumor-induced bone disease (TIBD) remains highly debilitating for many cancer patients and progression typically results in death within two years. Therefore, more effective therapies with enhanced anti-resorptive and cytotoxic characteristics are needed. We developed bisphosphonate-chemotherapeutic conjugates designed to bind bone and hydrolyze, releasing both compounds, thereby targeting both osteoclasts and tumor cells. This study examined the effects of our lead compound, MBC-11 (the anhydride formed between arabinocytidine (AraC)-5'-phosphate and etidronate), on bone tumor burden, bone volume, femur bone mineral density (BMD), and overall survival using two distinct mouse models of TIBD, the 4T1/luc breast cancer and the KAS-6/1-MIP1alpha multiple myeloma models. In mice orthotopically inoculated with 4T1/luc mouse mammary cells, MBC-11 (0.04 microg/day; s.c.) reduced the incidence of bone metastases to 40% (4/10), compared to 90% (9/10; p=0.057) and 100% (5/5; p=0.04) of PBS- or similarly-dosed, zoledronate-treated mice, respectively. MBC-11 also significantly decreased bone tumor burden compared to PBS- or zoledronate-treated mice (p=0.021, p=0.017, respectively). MBC-11 and zoledronate (0.04 microg/day) significantly increased bone volume by two- and four-fold, respectively, compared to PBS-treated mice (p=0.005, p<0.001, respectively). In mice systemically injected with human multiple myeloma KAS-6/1-MIP1alpha cells, 0.04 and 4.0 microg/day MBC-11 improved femur BMD by 13% and 16%, respectively, compared to PBS (p=0.025, p=0.017, respectively) at 10 weeks post-tumor cell injection and increased mean survival to 95 days compared to 77 days in mice treated with PBS (p=0.047). Similar doses of zoledronate also improved femur BMD (p< or =0.01 vs PBS) and increased mean survival to 86 days, but this was not significantly different than in PBS-treated mice (p=0.53). These results demonstrate that MBC-11 decreases bone tumor burden

  16. A Promising Approach for Treatment of Tumor-Induced Bone Diseases: Utilizing Bisphosphonate Derivatives of Nucleoside Antimetabolites*

    PubMed Central

    Reinholz, Monica M.; Zinnen, Shawn P.; Dueck, Amylou C.; Dingli, David; Reinholz, Gregory G.; Jonart, Leslie A.; Kitzmann, Kathleen A.; Bruzek, Amy K.; Negron, Vivian; Abdalla, Abdalla K.; Arendt, Bonnie K.; Croatt, Anthony J.; Sanchez-Perez, Luis; Sebesta, David P.; Lönnberg, Harri; Yoneda, Toshiyuki; Nath, Karl A.; Jelinek, Diane F.; Russell, Stephen J.; Ingle, James N.; Spelsberg, Thomas C.; (Hal) Dixon, Henry B.F.; Karpeisky, Alexander; Lingle, Wilma L.

    2010-01-01

    Despite palliative treatments, tumor-induced bone disease (TIBD) remains highly debilitating for many cancer patients and progression typically results in death within two years. Therefore, more effective therapies with enhanced antiresorptive and cytotoxic characteristics are needed. We developed bisphosphonate-chemotherapeutic conjugates designed to bind bone and hydrolyze, releasing both compounds, thereby targeting both osteoclasts and tumor cells. This study examined the effects of our lead compound, MBC-11 (the anhydride formed between arabinocytidine (AraC)-5’-phosphate and etidronate), on bone tumor burden, bone volume, femur bone mineral density (BMD), and overall survival using two distinct mouse models of TIBD, the 4T1/luc breast cancer and the KAS-6/1-MIP1α multiple myeloma models. In mice orthotopically inoculated with 4T1/luc mouse mammary cells, MBC-11 (0.04 µg/day; s.c.) reduced the incidence of bone metastases to 40% (4/10), compared to 90% (9/10; p=0.057) and 100% (5/5; p=0.04) of PBS- or similarly-dosed, zoledronate-treated mice, respectively. MBC-11 also significantly decreased bone tumor burden compared to PBS- or zoledronate-treated mice (p=0.021, p=0.017, respectively). MBC-11 and zoledronate (0.04 µg/day) significantly increased bone volume by two- and four-fold, respectively, compared to PBS-treated mice (p=0.005, p<0.001, respectively). In mice systemically injected with human multiple myeloma KAS-6/1-MIP1α cells, 0.04 and 4.0 µg/day MBC-11 improved femur BMD by 13% and 16%, respectively, compared to PBS (p=0.025, p=0.017, respectively) at 10 weeks post-tumor cell injection and increased mean survival to 95 days compared to 77 days in mice treated with PBS (p=0.047). Similar doses of zoledronate also improved femur BMD (p≤0.01 vs PBS) and increased mean survival to 86 days, but this was not significantly different than in PBS-treated mice (p=0.53). These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone

  17. Patterns of Healthcare Utilization Among Veterans Infected With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) and Coinfected With HIV/HCV: Unique Burdens of Disease

    PubMed Central

    Katrak, Shereen; Park, Lawrence P.; Woods, Christopher; Muir, Andrew; Hicks, Charles; Naggie, Susanna

    2016-01-01

    Background. Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and the primary cause of liver transplantation in the United States, and coinfection with human immunodeficiency virus (HIV) increases the risk of comorbidities. However, healthcare utilization (HCU) patterns among HIV/HCV-coinfected patients are poorly understood. This study compared the rates of HCU and reasons for hospital admission among HCV-infected, HIV-infected, and HIV/HCV-coinfected veterans. Methods. Hepatitis C virus- and HIV-infected and HIV/HCV-coinfected veterans in care with the Department of Veterans Affairs (VA) from 1998 to 2009 (n = 335 371, n = 28 179, n = 13 471, respectively) were identified by HIV- and HCV-associated International Classification of Diseases, Ninth Revision codes from the clinical case registry. We assessed rates of HCU using emergency department (ED) visits, outpatient visits, and hospitalization and primary diagnoses associated with hospitalization. Independent risk factors associated with hospitalization were also examined. Results. Rates of outpatient and ED visits increased over the 11-year study period for all groups, with inpatient admission rates remaining stable. The HCU rates were consistently higher for the coinfected than other cohorts. The primary reason for hospital admission for all groups was psychiatric disease/substance use, accounting for 44% of all admissions. Nadir CD4 <350 cells/mm3 was associated with higher rates of hospitalization versus nadir CD4 >500 cells/mm3. Conclusions. As the current population of HCV-infected, HIV-infected, and HIV/HCV-coinfected veterans age, they will continue to place a substantial and increasing demand on the US healthcare system, particularly in their utilization of ED and outpatient services. These data suggest the need for an ongoing investment in mental health and primary care within the VA healthcare system. PMID:27704025

  18. Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders

    PubMed Central

    Barral, Serena; Kurian, Manju A.

    2016-01-01

    The study of neurological disorders often presents with significant challenges due to the inaccessibility of human neuronal cells for further investigation. Advances in cellular reprogramming techniques, have however provided a new source of human cells for laboratory-based research. Patient-derived induced pluripotent stem cells (iPSCs) can now be robustly differentiated into specific neural subtypes, including dopaminergic, inhibitory GABAergic, motorneurons and cortical neurons. These neurons can then be utilized for in vitro studies to elucidate molecular causes underpinning neurological disease. Although human iPSC-derived neuronal models are increasingly regarded as a useful tool in cell biology, there are a number of limitations, including the relatively early, fetal stage of differentiated cells and the mainly two dimensional, simple nature of the in vitro system. Furthermore, clonal variation is a well-described phenomenon in iPSC lines. In order to account for this, robust baseline data from multiple control lines is necessary to determine whether a particular gene defect leads to a specific cellular phenotype. Over the last few years patient-derived neural cells have proven very useful in addressing several mechanistic questions related to central nervous system diseases, including early-onset neurological disorders of childhood. Many studies report the clinical utility of human-derived neural cells for testing known drugs with repurposing potential, novel compounds and gene therapies, which then can be translated to clinical reality. iPSCs derived neural cells, therefore provide great promise and potential to gain insight into, and treat early-onset neurological disorders. PMID:27656126

  19. Outer planet satellites

    SciTech Connect

    Schenk, P.M. )

    1991-01-01

    Recent findings on the outer-planet satellites are presented, with special consideration given to data on the rheologic properties of ice on icy satellites, the satellite surfaces and exogenic processes, cratering on dead cratered satellites, volcanism, and the interiors of outer-planet satellites. Particular attention is given to the state of Titan's surface and the properties of Triton, Pluto, and Charon. 210 refs.

  20. Reduction and analysis of satellite magnetometer data

    NASA Technical Reports Server (NTRS)

    Regan, R. D.

    1978-01-01

    The broad-scale magnetic anomalies that appear in regional complications of aeromagnetic data, and in regional and global maps are discussed. Satellite data can be of value in defining such anomalies and invaluable, especially when utilized with airborne data, in their interpretation. The reduction and interpretation of satellite magnetometer data differ significantly from the standard techniques that are routinely applied to conventional measurements. The reduction of the data is discussed and its morphology is detailed. Interpretational techniques that are applicable are presented.

  1. Handbook on satellite communications and broadcasting

    NASA Astrophysics Data System (ADS)

    Askinazi, G. B.; Bykov, V. L.; Vodopianov, G. V.; D'Iachkova, M. N.; Kantor, L. Ia.; Model, A. M.; Pokras, A. M.; Timofeev, V. V.; Tsirlin, V. M.; Tsirlin, I. S.

    Principles underlying the design and operation of satellite communications systems (SCSs) are reviewed with emphasis on multiple-access techniques. Particular consideration is given to the quality characteristics of CSCs, the frequency ranges assigned to SCSs, an energy analysis of satellite lines, EMC aspects, and the effective utilization of the geostationary orbit. Also examined are the design of earth-station equipment, waveguides and multiplexing equipment, satellite antennas, reliability issues, the Ekran receiving installation, and Gradient-N and Gruppa multiple-access equipment.

  2. Technical developments in international satellite business services

    NASA Astrophysics Data System (ADS)

    Tan, P. P.

    At the conception of International Satellite Business Services (ISBS), it was a primary objective to provide flexibility for accommodating a variety of service requirements which might be established by mutual agreement between users. The design guidelines are to ensure that the space segment is efficiently utilized, while other satellite services are protected from interference. Other considerations are related to an acceptable earth segment cost, maximum connectivity in worldwide services, the capability of growth and a reasonably smooth transition into future systems, and the maintenance of high performance objectives. Attention is given to a system overview, the characteristics of satellites for ISBS, and technological developments with some application possibilities for ISBS.

  3. Satellite-to-satellite tracking experiment for global gravity field mapping

    NASA Technical Reports Server (NTRS)

    Upadhyay, Triveni N.; Jekeli, Christopher

    1989-01-01

    The satellite-to-satellite (STS) tracking concept for estimating gravitational parameters offers an attractive means to improve on regional and global gravity models in areas where data availability is limited. The extent to which the STS tracking measurements can be effectively utilized in global field models depends primarily on the satellite's altitude, number of satellites, and their orbit constellation. The estimation accuracy of the gravity field recovery also depends on the measurement accuracy of the sensors employed in the STS tracking concept. A comparison of the obtainable accuracies in the gravity field recovery using various STS tracking concepts was presented by Jekeli. The results of a feasibility study for a specific realization of the STS high-low tracking concept are summarized. In this realization, the high altitude satellites are the GPS satellites, and the low orbit satellite is the space shuttle. The GPS satellite constellation consists of 18 satellites in 6 orbital planes inclined at 55 deg. The shuttle orbit is at approximately 300 km, with an inclination of 30 deg. This specific configuration of high-low satellites for measuring perturbation in the gravity field is named the Air Foce STAGE (Shuttle GPS Tracking for Anomalous Gravitation Estimation) mission. The STAGE mission objective is to estimate the perturbations in gravity vector at the shuttle altitude to an accuracy of 1 mgal or better. Recent simulation studies have confirmed that the 1 mgal accuracy objective is near optimum for the STAGE mission.

  4. Utilization of Ayurveda in health care: an approach for prevention, health promotion, and treatment of disease. Part 1--Ayurveda, the science of life.

    PubMed

    Sharma, Hari; Chandola, H M; Singh, Gurdip; Basisht, Gopal

    2007-11-01

    Ayurveda is a natural health care system that originated in India more than 5000 years ago. Its main objective is to achieve optimal health and well-being through a comprehensive approach that addresses mind, body, behavior, and environment. Ayurveda emphasizes prevention and health promotion, and provides treatment for disease. It considers the development of consciousness to be essential for optimal health and meditation as the main technique for achieving this. Treatment of disease is highly individualized and depends on the psychophysiologic constitution of the patient. There are different dietary and lifestyle recommendations for each season of the year. Common spices are utilized in treatment, as well as herbs and herbal mixtures, and special preparations known as Rasayanas are used for rejuvenation, promotion of longevity, and slowing of the aging process. A group of purification procedures known as Panchakarma removes toxins from the physiology. Whereas Western allopathic medicine is excellent in handling acute medical crises, Ayurveda demonstrates an ability to manage chronic disorders that Western medicine has been unable to. It may be projected from Ayurveda's comprehensive approach, emphasis on prevention, and ability to manage chronic disorders that its widespread use would improve the health status of the world's population.

  5. Cost Utility Analysis of the Cervical Artificial Disc vs Fusion for the Treatment of 2-Level Symptomatic Degenerative Disc Disease: 5-Year Follow-up

    PubMed Central

    Yang, Zhuo; Nunley, Pierce; Stone, Marcus B.; Lee, Darrin; Kim, Kee D.

    2016-01-01

    BACKGROUND: The cervical total disc replacement (cTDR) was developed to treat cervical degenerative disc disease while preserving motion. OBJECTIVE: Cost-effectiveness of this intervention was established by looking at 2-year follow-up, and this update reevaluates our analysis over 5 years. METHODS: Data were derived from a randomized trial of 330 patients. Data from the 12-Item Short Form Health Survey were transformed into utilities by using the SF-6D algorithm. Costs were calculated by extracting diagnosis-related group codes and then applying 2014 Medicare reimbursement rates. A Markov model evaluated quality-adjusted life years (QALYs) for both treatment groups. Univariate and multivariate sensitivity analyses were conducted to test the stability of the model. The model adopted both societal and health system perspectives and applied a 3% annual discount rate. RESULTS: The cTDR costs $1687 more than anterior cervical discectomy and fusion (ACDF) over 5 years. In contrast, cTDR had $34 377 less productivity loss compared with ACDF. There was a significant difference in the return-to-work rate (81.6% compared with 65.4% for cTDR and ACDF, respectively; P = .029). From a societal perspective, the incremental cost-effective ratio (ICER) for cTDR was −$165 103 per QALY. From a health system perspective, the ICER for cTDR was $8518 per QALY. In the sensitivity analysis, the ICER for cTDR remained below the US willingness-to-pay threshold of $50 000 per QALY in all scenarios (−$225 816 per QALY to $22 071 per QALY). CONCLUSION: This study is the first to report the comparative cost-effectiveness of cTDR vs ACDF for 2-level degenerative disc disease at 5 years. The authors conclude that, because of the negative ICER, cTDR is the dominant modality. ABBREVIATIONS: ACDF, anterior cervical discectomy and fusion AWP, average wholesale price CE, cost-effectiveness CEA, cost-effectiveness analysis CPT, Current Procedural Terminology cTDR, cervical total disc

  6. Changes Over Time in the Utilization of Disease-Related Internet Information in Newly Diagnosed Breast Cancer Patients 2007 to 2013

    PubMed Central

    Kahana, Eva; Kuhr, Kathrin; Ansmann, Lena; Pfaff, Holger

    2014-01-01

    Background As the number of people with Internet access rises, so does the use of the Internet as a potentially valuable source for health information. Insight into patient use of this information and its correlates over time may reveal changes in the digital divide based on patient age and education. Existing research has focused on patient characteristics that predict Internet information use and research on treatment context is rare. Objective This study aims to (1) present data on the proportion of newly diagnosed breast cancer patients treated in German breast centers from 2007 to 2013 who used the Internet for information on their disease, (2) look into correlations between Internet utilization and sociodemographic characteristics and if these change over time, and (3) determine if use of Internet information varies with the hospitals in which the patients were initially treated. Methods Data about utilization of the Internet for breast cancer–specific health information was obtained in a postal survey of breast cancer patients that is conducted annually in Germany with a steady response rate of 87% of consenting patients. Data from the survey were combined with data obtained by hospital personnel (eg, cancer stage and type of surgery). Data from 27,491 patients from 7 consecutive annual surveys were analyzed for this paper using multilevel regression modeling to account for clustering of patients in specific hospitals. Results Breast cancer patients seeking disease-specific information on the Internet increased significantly from 26.96% (853/3164) in 2007 to 37.21% (1485/3991) in 2013. Similar patterns of demographic correlates were found for all 7 cohorts. Older patients (≥70 years) and patients with <10 years of formal education were less likely to use the Internet for information on topics related to their disease. Internet use was significantly higher among privately insured patients and patients living with a partner. Higher cancer stage and a

  7. Satellite-Based Quantum Communications

    SciTech Connect

    Hughes, Richard J; Nordholt, Jane E; McCabe, Kevin P; Newell, Raymond T; Peterson, Charles G

    2010-09-20

    Single-photon quantum communications (QC) offers the attractive feature of 'future proof', forward security rooted in the laws of quantum physics. Ground based quantum key distribution (QKD) experiments in optical fiber have attained transmission ranges in excess of 200km, but for larger distances we proposed a methodology for satellite-based QC. Over the past decade we have devised solutions to the technical challenges to satellite-to-ground QC, and we now have a clear concept for how space-based QC could be performed and potentially utilized within a trusted QKD network architecture. Functioning as a trusted QKD node, a QC satellite ('QC-sat') could deliver secret keys to the key stores of ground-based trusted QKD network nodes, to each of which multiple users are connected by optical fiber or free-space QC. A QC-sat could thereby extend quantum-secured connectivity to geographically disjoint domains, separated by continental or inter-continental distances. In this paper we describe our system concept that makes QC feasible with low-earth orbit (LEO) QC-sats (200-km-2,000-km altitude orbits), and the results of link modeling of expected performance. Using the architecture that we have developed, LEO satellite-to-ground QKD will be feasible with secret bit yields of several hundred 256-bit AES keys per contact. With multiple ground sites separated by {approx} 100km, mitigation of cloudiness over any single ground site would be possible, potentially allowing multiple contact opportunities each day. The essential next step is an experimental QC-sat. A number of LEO-platforms would be suitable, ranging from a dedicated, three-axis stabilized small satellite, to a secondary experiment on an imaging satellite. to the ISS. With one or more QC-sats, low-latency quantum-secured communications could then be provided to ground-based users on a global scale. Air-to-ground QC would also be possible.

  8. Increased cardiopulmonary disease risk in a community-based sample with chemical odor intolerance: implications for women's health and health-care utilization.

    PubMed

    Baldwin, C M; Bell, I R

    1998-01-01

    Chemical intolerance, or reported illness from odors of common environmental chemicals (e.g., car exhaust, pesticides), is emerging as an important environmental and public health-care issue. Epidemiologic methods provide relevant heuristic devices for studies of complex disorders, such as chemical intolerance. The authors examined personal and reported parental cardiopulmonary disease prevalence rates in a community sample of chemically intolerant and control individuals. A county government (Tucson, Arizona) employee and kin subset (N = 181; 113 households) completed standard health questionnaires. Investigators determined chemical intolerance (n = 41/181) from self-reports of individuals who felt "moderately" to "severely" ill from exposure to at least three of five chemicals (i.e., car exhaust, pesticides, paint, new carpet, and perfume) on a Chemical Odor Intolerance Index. The authors chose the control group (n = 57/181) on the basis of self-reports of "never" feeling ill on the Chemical Odor Intolerance Index. The chemically intolerant group, which primarily comprised women (78% versus 51% of controls, p < .05), was significantly more likely to report-and to have sought--medical attention for heart problems, bronchitis, asthma, and pneumonia. Reports of heart problems in the chemically intolerant index cases and the occurrence of heart disease in both of their parents were significant (Fisher's p < .05). The chemically intolerant individuals were also significantly more likely to report maternal histories of chest problems (e.g., inhalant allergens, tuberculosis) than controls. The findings of the study suggested that the chemically intolerant individuals (a preponderance of whom were women [sex-related risk]) were more likely to have (a) reported cardiopulmonary problems (i.e., greater health risk); (b) actively sought medical care for these problems (i.e., increased medical utilization); and (c) reported more parental illnesses-particularly heart disease

  9. Utilization of the National Health and Nutrition Examination (NHANES) Survey for Symptoms, Tests, and Diagnosis of Chronic Respiratory Diseases and Assessment of Second hand Smoke Exposure

    PubMed Central

    Ocasio, Manuel A.; Wanner, Adam; Fleming, Lora E.; Lee, David J.

    2015-01-01

    Background Respiratory diseases encompass a number of complex disorders that constitute a major cause of both morbidity and mortality worldwide with a major burden to the afflicted as well as the health care systems that care for them. Although the prevalence of chronic respiratory diseases (CRDs) has been decreasing in industrialized countries due to a decreasing number of smokers and stricter laws aimed at reducing exposure to secondhand smoke (SHS), the burden of CRDs in developing world populations is expected to worsen due to communicable disease prevention programs, aging populations, environmental air pollution, and continued tobacco smoke exposure. Although tobacco smoking has been shown to be significantly associated with many CRDs, evidence linking SHS exposure to different CRDs is mixed, especially with low levels of SHS exposure. Methods The National Health and Nutrition Examination Survey (NHANES) is a series of studies designed to assess the health and nutritional status of non-institutionalized adults and children in the United States (U.S.). In addition to being used to monitor the health of the U.S. population, NHANES data allow for research into prevalent health problems and their risk factors in the population, such with CRDs and SHS exposure. NHANES data can be utilized to explore a variety of issues related to the assessment of SHS exposure and its association to respiratory symptoms and illnesses. Results First, we provide a brief review of NHANES including its strengths and limitations. We then provide a summary of the variables and publically available population based data that can be used to study associations between SHS exposure and CRD symptoms, testing and diagnoses. Conclusion Rich and cost effective, NHANES data provide a unique opportunity for research into the risk factors for CRDs in the U.S. population, particularly into the possible health effects of low levels of SHS exposure. PMID:26052473

  10. Satellites as Sentinels for Environment & Health

    NASA Technical Reports Server (NTRS)

    Maynard, Nancy G.

    2002-01-01

    Satellites as Sentinels for Environment & Health Remotely-sensed data and observations are providing powerful new tools for addressing human and ecosystem health by enabling improved understanding of the relationships and linkages between health-related environmental parameters and society as well as techniques for early warning of potential health problems. NASA Office of Earth Science Applications Program has established a new initiative to utilize its data, expertise, and observations of the Earth for public health applications. In this initiative, lead by Goddard Space Flight Center, remote sensing, geographic information systems, improved computational capabilities, and interdisciplinary research between the Earth and health science communities are being combined in rich collaborative efforts resulting in more rapid problem-solving, early warning, and prevention in global health issues. This presentation provides a number of recent examples of applications of advanced remote sensing and other technologies to health.and security issues related to the following: infectious and vector-borne diseases; urban, regional and global air pollution; African and Asian airborne dust; heat stress; UV radiation; water-borne disease; extreme weather; contaminant pathways (ocean, atmosphere, ice)

  11. Electric propulsion for small satellites

    NASA Astrophysics Data System (ADS)

    Keidar, Michael; Zhuang, Taisen; Shashurin, Alexey; Teel, George; Chiu, Dereck; Lukas, Joseph; Haque, Samudra; Brieda, Lubos

    2015-01-01

    Propulsion is required for satellite motion in outer space. The displacement of a satellite in space, orbit transfer and its attitude control are the task of space propulsion, which is carried out by rocket engines. Electric propulsion uses electric energy to energize or accelerate the propellant. The electric propulsion, which uses electrical energy to accelerate propellant in the form of plasma, is known as plasma propulsion. Plasma propulsion utilizes the electric energy to first, ionize the propellant and then, deliver energy to the resulting plasma leading to plasma acceleration. Many types of plasma thrusters have been developed over last 50 years. The variety of these devices can be divided into three main categories dependent on the mechanism of acceleration: (i) electrothermal, (ii) electrostatic and (iii) electromagnetic. Recent trends in space exploration associate with the paradigm shift towards small and efficient satellites, or micro- and nano-satellites. A particular example of microthruster considered in this paper is the micro-cathode arc thruster (µCAT). The µCAT is based on vacuum arc discharge. Thrust is produced when the arc discharge erodes some of the cathode at high velocity and is accelerated out the nozzle by a Lorentz force. The thrust amount is controlled by varying the frequency of pulses with demonstrated range to date of 1-50 Hz producing thrust ranging from 1 µN to 0.05 mN.

  12. Galileo satellite antenna modeling

    NASA Astrophysics Data System (ADS)

    Steigenberger, Peter; Dach, Rolf; Prange, Lars; Montenbruck, Oliver

    2015-04-01

    The space segment of the European satellite navigation system Galileo currently consists of six satellites. Four of them belong to the first generation of In-Orbit Validation (IOV) satellites whereas the other two are Full Operational Capability (FOC) satellites. High-precision geodetic applications require detailed knowledge about the actual phase center of the satellite and receiver antenna. The deviation of this actual phase center from a well-defined reference point is described by phase center offsets (PCOs) and phase center variations (PCVs). Unfortunately, no public information is available about the Galileo satellite antenna PCOs and PCVs, neither for the IOV, nor the FOC satellites. Therefore, conventional values for the IOV satellite antenna PCOs have been adopted for the Multi-GNSS experiment (MGEX) of the International GNSS Service (IGS). The effect of the PCVs is currently neglected and no PCOs for the FOC satellites are available yet. To overcome this deficiency in GNSS observation modeling, satellite antenna PCOs and PCVs are estimated for the Galileo IOV satellites based on global GNSS tracking data of the MGEX network and additional stations of the legacy IGS network. Two completely independent solutions are computed with the Bernese and Napeos software packages. The PCO and PCV values of the individual satellites are analyzed and the availability of two different solutions allows for an accuracy assessment. The FOC satellites are built by a different manufacturer and are also equipped with another type of antenna panel compared to the IOV satellites. Signal transmission of the first FOC satellite has started in December 2014 and activation of the second satellite is expected for early 2015. Based on the available observations PCO estimates and, optionally PCVs of the FOC satellites will be presented as well. Finally, the impact of the new antenna model on the precision and accuracy of the Galileo orbit determination is analyzed.

  13. Satellite Application for Disaster Management Information Systems

    NASA Astrophysics Data System (ADS)

    Okpanachi, George

    Abstract Satellites are becoming increasingly vital to modern day disaster management activities. Earth observation (EO) satellites provide images at various wavelengths that assist rapid-mapping in all phases of the disaster management cycle: mitigation of potential risks in a given area, preparedness for eventual disasters, immediate response to a disaster event, and the recovery/reconstruction efforts follo wing it. Global navigation satellite systems (GNSS) such as the Global Positioning System (GPS) assist all the phases by providing precise location and navigation data, helping manage land and infrastructures, and aiding rescue crews coordinate their search efforts. Effective disaster management is a complex problem, because it involves many parameters, which are usually not easy to measure and even identify: Analysis of current situation, planning, optimum resource management, coordination, controlling and monitoring current activities and making quick and correct decisions are only some of these parameters, whose complete list is very long. Disaster management information systems (DMIS) assist disaster management to analyse the situation better, make decisions and suggest further actions following the emergency plans. This requires not only fast and thorough processing and optimization abilities, but also real-time data provided to the DMIS. The need of DMIS for disaster’s real-time data can be satisfied by small satellites data utilization. Small satellites can provide up-to-data, plus a better media to transfer data. This paper suggests a rationale and a framework for utilization of small Satellite data by DMIS. DMIS should be used ‘’before’’, ‘’during’’ and ‘’after’’ the disasters. Data provided by the Small Satellites are almost crucial in any period of the disasters, because early warning can save lives, and satellite data may help to identify disasters before they occur. The paper also presents’ ‘when’’,

  14. Economic Utility of a Blood-Based Genomic Test for the Assessment of Patients with Symptoms Suggestive of Obstructive Coronary Artery Disease

    PubMed Central

    Hochheiser, Louis I.; Juusola, Jessie L.; Monane, Mark

    2014-01-01

    Abstract Approximately 3 million patients with symptoms suggestive of obstructive coronary artery disease (CAD) present to primary care offices in the United States annually, resulting in approximately $6.7 billion in cardiac workup costs. Despite wide application of existing diagnostic technologies, yield of obstructive CAD at invasive coronary angiography (ICA) is low. This study used a decision analysis model to assess the economic utility of a novel gene expression score (GES) for the diagnosis of obstructive CAD. Within a representative commercial health plan's adult membership, current practice for obstructive CAD diagnosis (usual care) was compared to a strategy that incorporates the GES test (GES-directed care). The model projected the number of diagnostic tests and procedures performed, the number of patients receiving medical therapy, type I and type II errors for each strategy of obstructive CAD diagnosis, and the associated costs over a 1-year time horizon. Results demonstrate that GES-directed care to exclude the diagnosis of obstructive CAD prior to myocardial perfusion imaging may yield savings to health plans relative to usual care by reducing utilization of noninvasive and invasive cardiac imaging procedures and increasing diagnostic yield at ICA. At a 50% capture rate of eligible patients in GES-directed care, it is projected that a commercial health plan will realize savings of $0.77 per member per month; savings increase proportionally to the GES capture rate. These findings illustrate the potential value of this new blood-based, molecular diagnostic test for health plans and patients in an age of greater emphasis on personalized medicine. (Population Health Management 2014;17:287–296) PMID:24568603

  15. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

    PubMed Central

    Aas, Eline; Odes, Selwyn; Småstuen, Milada; Stockbrugger, Reinhold; Hoff, Geir; Moum, Bjørn; Bernklev, Tomm

    2016-01-01

    Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36) was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution. PMID:27630711

  16. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

    PubMed Central

    Aas, Eline; Odes, Selwyn; Småstuen, Milada; Stockbrugger, Reinhold; Hoff, Geir; Moum, Bjørn; Bernklev, Tomm

    2016-01-01

    Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36) was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution.

  17. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis.

    PubMed

    Huppertz-Hauss, Gert; Aas, Eline; Lie Høivik, Marte; Langholz, Ebbe; Odes, Selwyn; Småstuen, Milada; Stockbrugger, Reinhold; Hoff, Geir; Moum, Bjørn; Bernklev, Tomm

    2016-01-01

    Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36) was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution. PMID:27630711

  18. Stereo Measurements from Satellites

    NASA Technical Reports Server (NTRS)

    Adler, R.

    1982-01-01

    The papers in this presentation include: 1) 'Stereographic Observations from Geosynchronous Satellites: An Important New Tool for the Atmospheric Sciences'; 2) 'Thunderstorm Cloud Top Ascent Rates Determined from Stereoscopic Satellite Observations'; 3) 'Artificial Stereo Presentation of Meteorological Data Fields'.

  19. Satellite-Delivered Learning.

    ERIC Educational Resources Information Center

    Arnall, Gail C.

    1987-01-01

    Discusses the application of satellite information delivery to training. Describes a new trend, horizontal programming. Also discusses vertical programming and in-house production of training materials. Lists vendors of satellite-based training. (CH)

  20. Labview utilities

    2011-09-30

    The software package provides several utilities written in LabView. These utilities don't form independent programs, but rather can be used as a library or controls in other labview programs. The utilities include several new controls (xcontrols), VIs for input and output routines, as well as other 'helper'-functions not provided in the standard LabView environment.

  1. Geology of icy satellites

    NASA Technical Reports Server (NTRS)

    Mckinnon, W. B.

    1985-01-01

    The geology of the major icy satellites of Jupiter, Saturn, Uranus, and Neptune is discussed in terms of the four major processes that shape icy satellite surfaces: impact cratering, volcanism, tectonism, and interactions with planetary magnetospheres and solar radiation. The role of these processes in creating the differences that exist among the satellites, in particular the orderly progression of geological properties in the Jovian satellites, is emphasized. Important questions left open after the Voyager missions are summarized.

  2. Recent weather extremes and impact agricultural production and vector-borne disease patterns

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We document significant worldwide weather anomalies that affected agriculture and vector-borne disease outbreaks during the 2010-2012 period. We utilized 2000-2012 vegetation index and land surface temperature data from NASA’s satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to ...

  3. Magnetospheres: Jupiter, Satellite Interactions

    NASA Astrophysics Data System (ADS)

    Neubauer, F.; Murdin, P.

    2000-11-01

    Most of the satellites of Jupiter, notably the large Galilean satellites Io, Europa, Ganymede and Callisto (see JUPITER: SATELLITES), orbit deep inside the magnetosphere of Jupiter (see JUPITER: MAGNETOSPHERE) and are therefore immersed in the flow of magnetospheric plasma (made of a mixture of electrons and ions) and subjected to an interaction with the strong Jovian magnetic field. These intera...

  4. The use of satellites in non-goestationary orbits for unloading geostationary communication satellite traffic peaks. Volume 2: Technical report

    NASA Astrophysics Data System (ADS)

    Price, K.; Turner, A.; Nguyen, T.; Doong, W.; Weyandt, C.

    1987-05-01

    The part of the geostationary (GEO) orbital arc used for United States domestic fixed, communications service is rapidly becoming filled with satellites. One of the factors currently limiting its utilization is that communications satellites must be designed to have sufficient capacity to handle peak traffic leads, and thus are under utilized most of the time. A solution is to use satellites in suitable non-geostationary orbits to unload the traffic peaks. Three different designs for a non-geostationary orbit communications satellite system are presented for the 1995 time frame. The economic performance is analyzed and compared with geostationary satellites for two classes of service, trunking and customer premise service. The result is that the larger payload of the non-geostationary satellite offsets the burdens of increased complexity and worse radiation environment to give improved economic performance. Depending on ground terminal configuration, the improved economic performance of the space segment may be offset by increased ground terminal expenses.

  5. The use of satellites in non-goestationary orbits for unloading geostationary communication satellite traffic peaks. Volume 2: Technical report

    NASA Technical Reports Server (NTRS)

    Price, K.; Turner, A.; Nguyen, T.; Doong, W.; Weyandt, C.

    1987-01-01

    The part of the geostationary (GEO) orbital arc used for United States domestic fixed, communications service is rapidly becoming filled with satellites. One of the factors currently limiting its utilization is that communications satellites must be designed to have sufficient capacity to handle peak traffic leads, and thus are under utilized most of the time. A solution is to use satellites in suitable non-geostationary orbits to unload the traffic peaks. Three different designs for a non-geostationary orbit communications satellite system are presented for the 1995 time frame. The economic performance is analyzed and compared with geostationary satellites for two classes of service, trunking and customer premise service. The result is that the larger payload of the non-geostationary satellite offsets the burdens of increased complexity and worse radiation environment to give improved economic performance. Depending on ground terminal configuration, the improved economic performance of the space segment may be offset by increased ground terminal expenses.

  6. Utility of point of care test devices for infectious disease testing of blood and oral fluid and application to rapid testing in the field

    NASA Astrophysics Data System (ADS)

    Lee, Stephen R.; Kardos, Keith W.; Yearwood, Graham D.; Guillon, Geraldine B.; Kurtz, Lisa A.; Mokkapati, Vijaya K.

    2008-04-01

    Rapid, point of care (POC) testing has been increasingly deployed as an aid in the diagnosis of infectious disease, due to its ability to deliver rapid, actionable results. In the case of HIV, a number of rapid test devices have been FDA approved and CLIA-waived in order to enable diagnosis of HIV infection outside of traditional laboratory settings. These settings include STD clinics, community outreach centers and mobile testing units, as well as identifying HIV infection among pregnant women and managing occupational exposure to infection. The OraQuick ® rapid test platform has been widely used to identify HIV in POC settings, due to its simplicity, ease of use and the ability to utilize oral fluid as an alternative specimen to blood. More recently, a rapid test for antibodies to hepatitis C virus (HCV) has been developed on the same test platform which uses serum, plasma, finger-stick blood, venous blood and oral fluid. Clinical testing using this POC test device has shown that performance is equivalent to state of the art, laboratory based tests. These devices may be suitable for rapid field testing of blood and other body fluids for the presence of infectious agents.

  7. Survey: National Environmental Satellite Service

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The national Environmental Satellite Service (NESS) receives data at periodic intervals from satellites of the Synchronous Meteorological Satellite/Geostationary Operational Environmental Satellite series and from the Improved TIROS (Television Infrared Observational Satellite) Operational Satellite. Within the conterminous United States, direct readout and processed products are distributed to users over facsimile networks from a central processing and data distribution facility. In addition, the NESS Satellite Field Stations analyze, interpret, and distribute processed geostationary satellite products to regional weather service activities.

  8. ATS-6 - Satellite-to-satellite tracking and data relay experiments

    NASA Technical Reports Server (NTRS)

    Schmid, P. E.; Trudell, B. J.; Vonbun, F. O.

    1975-01-01

    The paper describes the utilization of ATS-6 to relay tracking and telemetry data from Geos-5 and then from Nimbus-6. The experiment configuration consists of a ground station which receives data from ATS-6 through C-band links; ATS-6, in turn, transmits command data and receives telemetry data from the low-orbit satellites through S-band links. The ground and satellite equipment are described along with results of ground tests.

  9. Fundamentals of satellite navigation

    NASA Astrophysics Data System (ADS)

    Stiller, A. H.

    The basic operating principles and capabilities of conventional and satellite-based navigation systems for air, sea, and land vehicles are reviewed and illustrated with diagrams. Consideration is given to autonomous onboard systems; systems based on visible or radio beacons; the Transit, Cicada, Navstar-GPS, and Glonass satellite systems; the physical laws and parameters of satellite motion; the definition of time in satellite systems; and the content of the demodulated GPS data signal. The GPS and Glonass data format frames are presented graphically, and tables listing the GPS and Glonass satellites, their technical characteristics, and the (past or scheduled) launch dates are provided.

  10. Space industrialization - Education. [via communication satellites

    NASA Technical Reports Server (NTRS)

    Joels, K. M.

    1978-01-01

    The components of an educational system based on, and perhaps enhanced by, space industrialization communications technology are considered. Satellite technology has introduced a synoptic distribution system for various transmittable educational media. The cost of communications satellite distribution for educational programming has been high. It has, therefore, been proposed to utilize Space Shuttle related technology and Large Space Structures (LSS) to construct a system with a quantum advancement in communication capability and a quantum reduction in user cost. LSS for communications purposes have three basic advantages for both developed and emerging nations, including the ability to distribute signals over wide geographic areas, the reduced cost of satellite communications systems versus installation of land based systems, and the ability of a communication satellite system to create instant educational networks.

  11. Satellite Remote Sensing of Aerosol Forcing

    NASA Technical Reports Server (NTRS)

    Remer, Lorraine; Kaufman, Yoram; Ramaprasad, Jaya; Procopio, Aline; Levin, Zev

    1999-01-01

    Aerosol and cloud impacts on the earth's climate become a recent hot topic in climate studies. Having near future earth observing satellites, EOS-AM1 (Earth Observing System-AM1), ENVISAT (Environmental Satellites) and ADEOS-2 (Advanced Earth Observation Satellite-2), it will be a good timing to discuss how to obtain and use the microphysical parameters of aerosols and clouds for studying their climate impacts. Center for Climate System Research (CCSR) of the University of Tokyo invites you to 'Symposium on synergy between satellite-remote sensing and climate modeling in aerosol and cloud issues.' Here, we like to discuss the current and future issues in the remote sensing of aerosol and cloud microphysical parameters and their climate modeling studies. This workshop is also one of workshop series on aerosol remote sensing held in 1996, Washington D. C., and Meribel, France in 1999. It should be reminded that NASDA/ADEOS-1 & -2 (National Space Development Agency of Japan/Advanced Earth Observation Satellite-1 & -2) Workshop will be held in the following week (Dec. 6-10, 1999), so that this opportunity will be a perfect period for you to attend two meetings for satellite remote sensing in Japan. A weekend in Kyoto, the old capital of Japan, will add a nice memory to your visiting Japan. *Issues in the symposium: 1) most recent topics in aerosol and cloud remot sensing, and 2) utility of satellite products on climate modeling of cloud-aerosol effects.

  12. Planning for Satellite Broadcasting: The Indian Instructional Television Experiment.

    ERIC Educational Resources Information Center

    Chander, Romesh; Karnik, Kiran

    This document reports on the technical and programmatic planning stages of the Satellite Instructional Television Experiment (SITE), which was undertaken by India in 1975-76 utilizing the first satellite capable of transmitting television programs directly to community receivers. Programmatic planning includes program objectives, the mechanics of…

  13. Application of satellite data to tropic/subtropic moisture coupling

    NASA Technical Reports Server (NTRS)

    Thompson, A. H.; Mcguirk, J. P.

    1984-01-01

    The objective is to utilize various satellite products from a number of satellites together with data observed from platforms available during the FGGE Special Observing Periods to diagnose synoptic scale events in date void regions. The focus is on episodes of northeastward traveling cloud bands which move out of the ITCZ over the eastern North Pacific Ocean. These events are called moisture bursts.

  14. Geosynchronous satellite collision avoidance

    NASA Technical Reports Server (NTRS)

    Fraser, W.

    1985-01-01

    The increases in the number of satellite systems, the growing dependency on these systems, and the potentially hazardous conjunctions in space, dictates careful management of satellite positions. The potential for satellite collision increases as more objects are placed in orbit. At geosynchronous altitudes active satellites maintain fixed longitudinal station-keeping control while inactive satellites and debris generally drift around the globe or oscillate about two geopotential stable points. Portions of the total objects in geosynchronous orbit are tracked by ground stations while a significant number of additional pieces of space debris regularly pass through geosynchronous orbit altitudes. The probability of an operational satellite colliding with another satellite or a piece of space debris will increase in the number of space objects, their sizes, and on-orbit lifetimes.

  15. The PVUSA-Hawaii Satellite Project

    SciTech Connect

    Rezachek, D.A.; Seki, A.; Sakai, K.

    1995-11-01

    The Photovoltaics for Utility Scale Applications (PVUSA) Project is a national, cooperative research, development and demonstration program designed to promote utility-scale use of photovoltaics. Five 20-kilowatt-peak (nominal) emerging technologies, as well as several other photovoltaic systems, are being demonstrated at a site near Davis, California and one emerging technology system is being demonstrated at Kihei, Maui, Hawaii. The PVUSA-Hawaii Satellite Project was the first satellite system in the US. This paper describes the design, installation, operation and testing, maintenance, performance, and costs of the PVUSA-Hawaii Satellite Project. This system is compared to a similar system in Davis, and conclusions and recommendations based on more than five years of operation are presented.

  16. The PTV Satellite System: Turning Point or High Anxiety?

    ERIC Educational Resources Information Center

    Gingras, Richard

    1978-01-01

    The Westar I satellite communications system for public television is discussed, and rationale for the original construction of the system, programming capabilities utilizing multichannel distribution, and additional communications services are reviewed. (RAO)

  17. Comments on satellite meteorology from geostationary satellites

    NASA Technical Reports Server (NTRS)

    Vonderhaar, T. H.

    1982-01-01

    Examples of the use of geostationary satellites in meteorology are given. Studies of the rate of change of cumulus clouds and cloud systems and wind parameter determination from cloud motions are reviewed. Computer processed imagery products are also discussed.

  18. Space satellite to aid arctic oil development

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A project which utilizes the Nimbus-6 weather satellite and air-dropable data collection platforms for observation of Arctic ice movement is described. The information gained from the project could be valuable for planning oil recovery operations in the area.

  19. Muscle satellite cell heterogeneity and self-renewal.

    PubMed

    Motohashi, Norio; Asakura, Atsushi

    2014-01-01

    Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result of expansion and differentiation of a self-renewing pool of muscle stem cells termed muscle satellite cells. Normally, satellite cells are mitotically quiescent and reside beneath the basal lamina of muscle fibers. Upon regeneration, satellite cells are activated, and give rise to daughter myogenic precursor cells. After several rounds of proliferation, these myogenic precursor cells contribute to the formation of new muscle fibers. During cell division, a minor population of myogenic precursor cells returns to quiescent satellite cells as a self-renewal process. Currently, accumulating evidence has revealed the essential roles of satellite cells in muscle regeneration and the regulatory mechanisms, while it still remains to be elucidated how satellite cell self-renewal is molecularly regulated and how satellite cells are important in aging and diseased muscle. The number of satellite cells is decreased due to the changing niche during ageing, resulting in attenuation of muscle regeneration capacity. Additionally, in Duchenne muscular dystrophy (DMD) patients, the loss of satellite cell regenerative capacity and decreased satellite cell number due to continuous needs for satellite cells lead to progressive muscle weakness with chronic degeneration. Thus, it is necessary to replenish muscle satellite cells continuously. This review outlines recent findings regarding satellite cell heterogeneity, asymmetric division and molecular mechanisms in satellite cell self-renewal which is crucial for maintenance of satellite cells as a muscle stem cell pool throughout life. In addition, we discuss roles in the stem cell niche for satellite cell maintenance, as well as related cell therapies for approaching treatment of DMD.

  20. Wide swath and high resolution optical imaging satellite of Japan

    NASA Astrophysics Data System (ADS)

    Katayama, Haruyoshi; Kato, Eri; Imai, Hiroko; Sagisaka, Masakazu

    2016-05-01

    The "Advanced optical satellite" (tentative name) is a follow-on mission from ALOS. Mission objectives of the advanced optical satellite is to build upon the existing advanced techniques for global land observation using optical sensors, as well as to promote data utilization for social needs. Wide swath and high resolution optical imager onboard the advanced optical satellite will extend the capabilities of earlier ALOS missions. The optical imager will be able to collect high-resolution (< 1 m) and wide-swath (70 km) images with high geo-location accuracy. This paper introduces a conceptual design of the advanced optical satellite.

  1. Satellite services system overview

    NASA Technical Reports Server (NTRS)

    Rysavy, G.

    1982-01-01

    The benefits of a satellite services system and the basic needs of the Space Transportation System to have improved satellite service capability are identified. Specific required servicing equipment are discussed in terms of their technology development status and their operative functions. Concepts include maneuverable television systems, extravehicular maneuvering unit, orbiter exterior lighting, satellite holding and positioning aid, fluid transfer equipment, end effectors for the remote manipulator system, teleoperator maneuvering system, and hand and power tools.

  2. Satellite Antenna Systems

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Through the Technology Affiliates Program at the Jet Propulsion Laboratory, the ACTS antenna system was transferred from experimental testing status to commercial development with KVH Industries, Inc. The ACTS design enables mobile satellite antennas to remain pointed at the satellite, regardless of the motion or vibration on which it is mounted. KVH's first product based on the ACTS design is a land-mobile satellite antenna system that will enable direct broadcast satellite television aboard moving trucks, recreational vehicles, trains, and buses. Future products could include use in broadcasting, emergency medical and military vehicles.

  3. Satellite communication antenna technology

    NASA Technical Reports Server (NTRS)

    Mittra, R. (Editor); Imbriale, W. A. (Editor); Maanders, E. J. (Editor)

    1983-01-01

    A general overview of current technology in the field of communication satellite antennas is presented. Among the topics discussed are: the design of multiple beam systems; frequency reuse; and polarization control of antenna measurements. Consideration is also given to: contour beam synthesis; dual shaped reflector synthesis; beam shaping; and offset reflector design. The applications of the above technologies to present and future generations of communications satellites is considered, with emphasis given to such systems as: the Intelsats; the Defense Satellite Communications System, (DSCS-III); Satellite Business System (SBS), and Comstar.

  4. Satellite networks for education

    NASA Technical Reports Server (NTRS)

    Singh, J. P.; Morgan, R. P.; Rosenbaum, F. J.

    1972-01-01

    Satellite based educational networking is discussed with particular attention given to the potential uses of communications satellites to help meet educational needs in the United states. Four major subject areas were covered; (1) characteristics and structure of networks, (2) definition of pressures within educational establishment that provide motivation for various types of networks, (3) examination of current educational networking status for educational radio and television, instructional television fixed services, inter- and intra-state educational communication networks, computer networks, and cable television for education, and (4) identification of possible satellite based educational telecommunication services and three alternatives for implementing educational satellite systems.

  5. Satellite sound broadcast propagation studies and measurements

    NASA Technical Reports Server (NTRS)

    Vogel, Wolfhard J.; Torrence, Geoffrey W.

    1990-01-01

    Satellite Sound Broadcasting is an attractive satellite application. Before regulatory decisions can be made in 1992, the propagation effects encountered have to be characterized. The Electrical Engineering Research Laboratory has nearly completed a system which will allow amplitude measurements to be made over 10 MHz bandwidths in the 800 to 1800 MHz frequency range. The system uses transmission from a transportable tower, and reception inside buildings or in the shadow of trees or utility poles. The goal is to derive propagation models for use by systems engineers who are about to design satellite broadcast systems. The advance of fiber-optics technology has helped to focus future development of satellite services into areas where satellites are uniquely competitive. One of these preferred satellite applications is the broadcasting of high-quality sound for stationary or mobile reception by listeners using low-cost, consumer-grade receivers. Before such services can be provided, however, the political hurdles of spectrum allocation have to be surmounted and the technical questions of standardization for world-wide compatibility have to be resolved. In order to arrive at an optimal system design, efficient in the use of our scarce spectral resources, affordable both to the broadcaster and the listener, and providing predictable performance, the propagation effects to which the service is subjected have to be characterized. Consequently, the objective of the research project is to make basic propagation measurements for direct Satellite Sound Broadcasting Service (SSBS). The data obtained should allow the development of propagation models to be used by communications engineers designing the operational systems. Such models shall describe the effects of shadowing and multipath propagation on SSBS receivers operating in a specified environment, such as inside commercial or residential buildings of various construction and also in the shadow of trees or utility poles

  6. A systematic review of the application and utility of geographical information systems for exploring disease-disease relationships in paediatric global health research: the case of anaemia and malaria.

    PubMed

    Aimone, Ashley Mariko; Perumal, Nandita; Cole, Donald C

    2013-01-10

    Malaria and anaemia are important health problems among children globally. Iron deficiency anaemia may offer protection against malaria infection and iron supplementation may increase the risk of malaria-related hospitalization and mortality. The nature and mechanism of these relationships, however, remain largely unresolved, resulting in concern and uncertainty around policies for non-selective iron supplementation in malaria endemic areas. Use of geographical information systems (GIS) to investigate this disease-disease interaction could contribute important new information for developing safe and effective anaemia and malaria interventions. To assess the current state of knowledge we conducted a systematic review of peer-reviewed and grey literature. Our primary objective was to qualitatively assess the application and utility of geographical concepts or spatial analyses in paediatric global health research. The secondary objective was to identify geographical factors that may be associated with anaemia and malaria prevalence or incidence among children 0-5 years of age living in low- and middle-income countries. Evaluation tools for assessing the quality of geographical data could not be found in the peer-reviewed or grey literature, and thus adapted versions of the STROBE (Strengthening The Reporting of Observational Studies in Epidemiology) and GRADE (Grades of Recommendation, Assessment, Development and Evaluation) methods were used to create reporting, and overall evidence quality scoring systems. Among the 20 included studies, we found that both malaria and anaemia were more prevalent in rural communities compared to urban areas. Geographical factors associated with malaria prevalence included regional transmission stability, and proximity to a mosquito breeding area. The prevalence of anaemia tended to vary inversely with greater or poorer access to community services such as piped water. Techniques for investigating geographic relationships ranged from

  7. Broadband Satellite Technologies and Markets Assessed

    NASA Technical Reports Server (NTRS)

    Wallett, Thomas M.

    1999-01-01

    The current usage of broadband (data rate greater than 64 kilobits per second (kbs)) for multimedia network computer applications is increasing, and the need for network communications technologies and systems to support this use is also growing. Satellite technology will likely be an important part of the National Information Infrastructure (NII) and the Global Information Infrastructure (GII) in the next decade. Several candidate communications technologies that may be used to carry a portion of the increased data traffic have been reviewed, and estimates of the future demand for satellite capacity have been made. A study was conducted by the NASA Lewis Research Center to assess the satellite addressable markets for broadband applications. This study effort included four specific milestones: (1) assess the changing nature of broadband applications and their usage, (2) assess broadband satellite and terrestrial technologies, (3) estimate the size of the global satellite addressable market from 2000 to 2010, and (4) identify how the impact of future technology developments could increase the utility of satellite-based transport to serve this market.

  8. Mean sea level determination from satellite altimetry

    NASA Technical Reports Server (NTRS)

    Kahn, W. D.; Agrawal, B. B.; Brown, R. D.

    1977-01-01

    The primary experiment on the Geodynamics Experimental Ocean Satellite-3 (GEOS-3) is the radar altimeter. This experiment's major objective is to demonstrate the utility of measuring the geometry of the ocean surface, i.e. the geoid. Results obtained from this experiment so far indicate that the planned objectives of measuring the topography of the ocean surface with an absolute accuracy of + or - 5 meters can be met and perhaps exceeded. The GEOS-3 satellite altimeter measurements have an instrument precision in the range of + or - 25 cm to + or - 50 cm when the altimeter is operating in the short pulse mode.

  9. Communications technology satellite

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A description of the Communications Technology Satellite (CTS), its planned orbit, its experiments, and associated ground facilities was given. The communication experiments, to be carried out by a variety of groups in both the United States and Canada, include tele-education, tele-medicine, community interaction, data communications and broadcasting. A historical summary of communications satellite development was also included.

  10. Satellite Teleconference Final Report.

    ERIC Educational Resources Information Center

    Elgin Community Coll., IL.

    The vocational education satellite teleconference project accomplished two goals: (1) identified, acquired, copied, and distributed to the Illinois Vocational Curriculum Center 100 marketing or training videotapes for staff development and classroom use; and (2) provided from 15-25 variable time (1- to 3-hour) satellite teleconferences in four…

  11. Communication satellite technology trends

    NASA Technical Reports Server (NTRS)

    Cuccia, Louis

    1986-01-01

    A chronology of space-Earth interconnectivity is presented. The Advanced Communications Technology Satellite (ACTS) system, Land Mobile Satellite, space-Earth antennas, impact of antenna size on coverage, intersatellite links are outlined. This presentation is represented by graphs and charts only.

  12. Satellites in Schools.

    ERIC Educational Resources Information Center

    Underwood, C. I.; And Others

    1987-01-01

    Discusses the use of satellite data in physics classrooms. Describes the apparatus that can be used to collect and analyze data. Provides examples of how telemetry data transmitted by the satellite UoSAT-2 can be used not only in teaching physics, but also in geography, mathematics, and information technology. (TW)

  13. Signals from Communications Satellites.

    ERIC Educational Resources Information Center

    Thomsen, Volker

    1996-01-01

    Discusses the Doppler effect for relative motion between a source of waves and an observer and the orbital dynamics of communications satellites. Presents preliminary calculations of the satellite's altitude and linear velocity using only the concepts of the Doppler shift and the mechanics of motion in a circular path. (JRH)

  14. Audio direct broadcast satellites

    NASA Astrophysics Data System (ADS)

    Miller, J. E.

    1983-05-01

    Satellite sound broadcasting is, as the name implies, the use of satellite techniques and technology to broadcast directly from space to low-cost, consumer-quality receivers the types of sound programs commonly received in the AM and FM broadcast bands. It would be a ubiquitous service available to the general public in the home, in the car, and out in the open.

  15. Seminar by Satellite

    ERIC Educational Resources Information Center

    Hart, Peter J.

    1978-01-01

    Seminars on curriculum development transmitted by satellite are operated by the University of the South Pacific, Suva. The satellite was launched in 1966 by NASA, which has permitted educational broadcasting. Ground stations have been set up in eight countries that support the university. Practical aspects of transmission are outlined. (SW)

  16. Audio direct broadcast satellites

    NASA Technical Reports Server (NTRS)

    Miller, J. E.

    1983-01-01

    Satellite sound broadcasting is, as the name implies, the use of satellite techniques and technology to broadcast directly from space to low-cost, consumer-quality receivers the types of sound programs commonly received in the AM and FM broadcast bands. It would be a ubiquitous service available to the general public in the home, in the car, and out in the open.

  17. DS-CDMA satellite diversity reception for personal satellite communication: Downlink performance analysis

    NASA Technical Reports Server (NTRS)

    DeGaudenzi, Riccardo; Giannetti, Filippo

    1995-01-01

    The downlink of a satellite-mobile personal communication system employing power-controlled Direct Sequence Code Division Multiple Access (DS-CDMA) and exploiting satellite-diversity is analyzed and its performance compared with a more traditional communication system utilizing single satellite reception. The analytical model developed has been thoroughly validated by means of extensive Monte Carlo computer simulations. It is shown how the capacity gain provided by diversity reception shrinks considerably in the presence of increasing traffic or in the case of light shadowing conditions. Moreover, the quantitative results tend to indicate that to combat system capacity reduction due to intra-system interference, no more than two satellites shall be active over the same region. To achieve higher system capacity, differently from terrestrial cellular systems, Multi-User Detection (MUD) techniques are likely to be required in the mobile user terminal, thus considerably increasing its complexity.

  18. Satellites and the ISDN

    NASA Astrophysics Data System (ADS)

    Lewis, J.

    1983-12-01

    The potential role of satellites in an integrated services digital network (ISDN) is discussed in the light of recent CCITT studies. Present satellite digital-communication techniques are reviewed, and the changes introduced by ISDN development and by the competition of long-distance optical-fiber networks are characterized. CCITT standards on error performance (e.g., bit-error rate less than 10 to the -6th for at least 98 percent of the worst month), availability, and synchronization are summarized and compared with currently applied satellite standards. Since the potential for improvements in transmission quality and delay in satellite systems is limited, it is recommended that satellite planning concentrate on transparency enhancement (including speech processing, frame-format modification, and forward error correction) to accommodate ISDN.

  19. Isolation, culture, and transplantation of muscle satellite cells.

    PubMed

    Motohashi, Norio; Asakura, Yoko; Asakura, Atsushi

    2014-01-01

    Muscle satellite cells are a stem cell population required for postnatal skeletal muscle development and regeneration, accounting for 2-5% of sublaminal nuclei in muscle fibers. In adult muscle, satellite cells are normally mitotically quiescent. Following injury, however, satellite cells initiate cellular proliferation to produce myoblasts, their progenies, to mediate the regeneration of muscle. Transplantation of satellite cell-derived myoblasts has been widely studied as a possible therapy for several regenerative diseases including muscular dystrophy, heart failure, and urological dysfunction. Myoblast transplantation into dystrophic skeletal muscle, infarcted heart, and dysfunctioning urinary ducts has shown that engrafted myoblasts can differentiate into muscle fibers in the host tissues and display partial functional improvement in these diseases. Therefore, the development of efficient purification methods of quiescent satellite cells from skeletal muscle, as well as the establishment of satellite cell-derived myoblast cultures and transplantation methods for myoblasts, are essential for understanding the molecular mechanisms behind satellite cell self-renewal, activation, and differentiation. Additionally, the development of cell-based therapies for muscular dystrophy and other regenerative diseases are also dependent upon these factors. However, current prospective purification methods of quiescent satellite cells require the use of expensive fluorescence-activated cell sorting (FACS) machines. Here, we present a new method for the rapid, economical, and reliable purification of quiescent satellite cells from adult mouse skeletal muscle by enzymatic dissociation followed by magnetic-activated cell sorting (MACS). Following isolation of pure quiescent satellite cells, these cells can be cultured to obtain large numbers of myoblasts after several passages. These freshly isolated quiescent satellite cells or ex vivo expanded myoblasts can be transplanted

  20. An advanced domestic satellite communications system

    NASA Technical Reports Server (NTRS)

    1980-01-01

    An updated traffic projection for U.S. domestic satellite communications service covering a period of 15 years; mid-1980 to mid-1995 was prepared. This model takes into account expected technology advances and reductions in transmission costs, legislative and regulatory changes permitting increased competition, and rising energy costs which will encourage more extensive substitution of telecommunications for travel. The historical development and current status of satellite systems are discussed as well as the characteristics of follow-on systems. Orbital arc utilization, spacecraft configuration for single shuttle launch, Earth station configuration, and system costs are examined. Areas which require technology development include multiple beam frequency reuse antennas, on-board switching, intersatellite links, and ka-band operation. Packing and deployment schemes for enclosing the satellite within the shuttle orbiter bay must also be devised.

  1. Use of satellite data in volcano monitoring

    NASA Technical Reports Server (NTRS)

    Mcclelland, Lindsay

    1987-01-01

    It is argued that Total Ozone Mapping Spectrometer (TOMS) data, especially data on sulfur dioxide detection in volcanic clouds, and weather satellite data complement each other. TOMS data is most useful for discovering previously unknown eruptions and indicating a minimum volume of SO sub 2 produced by a given eruption. Once an eruption has been reported, weather satellite data can be used to accurately monitor its progress. To be used effectively, these data need to be analyzed jointly and in real time. Toward this end, it is hoped that full and timely utilization can be made of existing TOMS data, a polar orbiting TOMS can be launched in the near future, and that TOMS type instruments can be included on future geostationary satellites.

  2. Transit satellite system timing capabilities

    NASA Technical Reports Server (NTRS)

    Finsod, T. D.

    1978-01-01

    Current time transfer capabilities of the Transit Satellite System are reviewed. Potential improvements in the changes in equipment and operational procedures using operational satellites are discussed.

  3. Satellite Services Workshop, Volume 1

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Key issues associated with the orbital servicing of satellites are examined including servicing spacecraft and equipment, servicing operations, economics, satellite design, docking and berthing, and fluid management.

  4. Swedish small satellites

    NASA Astrophysics Data System (ADS)

    Lundahl, K.; von Scheele, F.

    2004-11-01

    In 1986 the first Swedish small satellite VIKING was launched on the Ariane 1 rocket together with the French remote sensing satellite SPOT-1. This paper describes the development of Swedish small satellites in an international framework. The satellites have delivered excellent scientific data to a low cost by using e.g. streamlined project organisations, competitive procurement programs and piggy-back launch opportunities. The first micro satellite Astrid-1 was launched in January 1995 and was followed by the launch of Astrid-2 in December 1998. The capable Odin small satellite was launched in February 2001. SSC was also contracted for ESA's SMART-1 probe destined to the Moon. SMART-1, launched in September 2003, is used for both research and as a technology demonstrator for future projects. Future proposed projects include micro and small satellites for climate research as the Atmosphere and Climate Explorer Plus (ACE+), the Stratosphere-Troposphere Exchange And climate Monitor (STEAM) and PRISMA, a technology demonstrator for formation flying, new propulsion system and commercial development methods.

  5. Design of a Representative Low Earth Orbit Satellite to Improve Existing Debris Models

    NASA Technical Reports Server (NTRS)

    Clark, S.; Dietrich, A.; Werremeyer, M.; Fitz-Coy, N.; Liou, J.-C.

    2012-01-01

    This paper summarizes the process and methodologies used in the design of a small-satellite, DebriSat, that represents materials and construction methods used in modern day Low Earth Orbit (LEO) satellites. This satellite will be used in a future hypervelocity impact test with the overall purpose to investigate the physical characteristics of modern LEO satellites after an on-orbit collision. The major ground-based satellite impact experiment used by DoD and NASA in their development of satellite breakup models was conducted in 1992. The target used for that experiment was a Navy Transit satellite (40 cm, 35 kg) fabricated in the 1960 s. Modern satellites are very different in materials and construction techniques from a satellite built 40 years ago. Therefore, there is a need to conduct a similar experiment using a modern target satellite to improve the fidelity of the satellite breakup models. The design of DebriSat will focus on designing and building a next-generation satellite to more accurately portray modern satellites. The design of DebriSat included a comprehensive study of historical LEO satellite designs and missions within the past 15 years for satellites ranging from 10 kg to 5000 kg. This study identified modern trends in hardware, material, and construction practices utilized in recent LEO missions, and helped direct the design of DebriSat.

  6. Lighting Utilization.

    ERIC Educational Resources Information Center

    Crank, Ron

    This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with lighting utilization. Its objective is for the student to be able to outline the development of lighting use and conservation and identify major types and operating characteristics of lamps used in electric lighting. Some topics…

  7. Skeletal muscle satellite cells

    NASA Technical Reports Server (NTRS)

    Schultz, E.; McCormick, K. M.

    1994-01-01

    Evidence now suggests that satellite cells constitute a class of myogenic cells that differ distinctly from other embryonic myoblasts. Satellite cells arise from somites and first appear as a distinct myoblast type well before birth. Satellite cells from different muscles cannot be functionally distinguished from one another and are able to provide nuclei to all fibers without regard to phenotype. Thus, it is difficult to ascribe any significant function to establishing or stabilizing fiber type, even during regeneration. Within a muscle, satellite cells exhibit marked heterogeneity with respect to their proliferative behavior. The satellite cell population on a fiber can be partitioned into those that function as stem cells and those which are readily available for fusion. Recent studies have shown that the cells are not simply spindle shaped, but are very diverse in their morphology and have multiple branches emanating from the poles of the cells. This finding is consistent with other studies indicating that the cells have the capacity for extensive migration within, and perhaps between, muscles. Complexity of cell shape usually reflects increased cytoplasmic volume and organelles including a well developed Golgi, and is usually associated with growing postnatal muscle or muscles undergoing some form of induced adaptive change or repair. The appearance of activated satellite cells suggests some function of the cells in the adaptive process through elaboration and secretion of a product. Significant advances have been made in determining the potential secretion products that satellite cells make. The manner in which satellite cell proliferative and fusion behavior is controlled has also been studied. There seems to be little doubt that cellcell coupling is not how satellite cells and myofibers communicate. Rather satellite cell regulation is through a number of potential growth factors that arise from a number of sources. Critical to the understanding of this form

  8. Satellite Breakup Risk Mitigation

    NASA Technical Reports Server (NTRS)

    Leleux, Darrin P.; Smith, Jason T.

    2006-01-01

    Many satellite breakups occur as a result of an explosion of stored energy on-board spacecraft or rocket-bodies. These breakups generate a cloud of tens or possibly hundreds of thousands of debris fragments which may pose a transient elevated threat to spaceflight crews and vehicles. Satellite breakups pose a unique threat because the majority of the debris fragments are too small to be tracked from the ground. The United States Human Spaceflight Program is currently implementing a risk mitigation strategy that includes modeling breakup events, establishing action thresholds, and prescribing corresponding mitigation actions in response to satellite breakups.

  9. Probability of satellite collision

    NASA Technical Reports Server (NTRS)

    Mccarter, J. W.

    1972-01-01

    A method is presented for computing the probability of a collision between a particular artificial earth satellite and any one of the total population of earth satellites. The collision hazard incurred by the proposed modular Space Station is assessed using the technique presented. The results of a parametric study to determine what type of satellite orbits produce the greatest contribution to the total collision probability are presented. Collision probability for the Space Station is given as a function of Space Station altitude and inclination. Collision probability was also parameterized over miss distance and mission duration.

  10. JOI reaffirms satellite plan

    NASA Astrophysics Data System (ADS)

    Katzoff, Judith A.

    A recent report by the Satellite Planning Committee of Joint Oceanographic Institutions, Inc. (JOI), Washington, D.C., underscored the need for the four oceanographic satellite missions that have been proposed for the next decade to be carried out as planned and firmly on schedule. In reaffirming the need for the missions, the committee said that many important types of long-term global data auoui ihe oceans can be gathered only by research satellites. The potential benefits to vital national activities such as trade, fisheries, national defense, and waste disposal will be well worth the missions' cost, they added.

  11. Satellite Cells in Muscular Dystrophy - Lost in Polarity.

    PubMed

    Chang, Natasha C; Chevalier, Fabien P; Rudnicki, Michael A

    2016-06-01

    Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD) have revealed that muscle satellite stem cells play a direct role in contributing to disease etiology and progression of DMD, the most common and severe form of muscular dystrophy. Lack of dystrophin expression in DMD has critical consequences in satellite cells including an inability to establish cell polarity, abrogation of asymmetric satellite stem-cell divisions, and failure to enter the myogenic program. Thus, muscle wasting in dystrophic mice is not only caused by myofiber fragility but is exacerbated by intrinsic satellite cell dysfunction leading to impaired regeneration. Despite intense research and clinical efforts, there is still no effective cure for DMD. In this review we highlight recent research advances in DMD and discuss the current state of treatment and, importantly, how we can incorporate satellite cell-targeted therapeutic strategies to correct satellite cell dysfunction in DMD.

  12. Overview of commercial satellite communications

    NASA Astrophysics Data System (ADS)

    Beakley, G. W.

    1984-07-01

    A brief history of communications satellites is presented, taking into account the launching of Sputnik 1 in October 1957, the Explorer 1 in January of 1958, the launch of the Score as the world's first active communications satellite in December 1958, the Communications Satellite Act in 1962, and the launch of 'Early Bird' in 1964. The Intelsat satellites are considered along with maritime satellite communications, the U.S. domestic satellite systems, Alaskan satellite communications, cable television, broadcast TV stations, print media, the hotel/motel industry as a large market for satellite communications terminals, the opening of a minicable and satellite master antenna TV market for TV receive-only systems, and business telecommunications earth terminals. Attention is also given to future directions regarding satellite positions, the concept of 'video-plus', and direct broadcast satellites.

  13. Multicolour Optical Photometry of Active Geostationary Satellites

    NASA Astrophysics Data System (ADS)

    Jolley, A.; Wade, G.; Bedard, D.

    Although broadband photometry has been used to infer information about artificial satellites since soon after the launch of Sputnik 1, the development of photometric techniques for non-resolved space object identification or characterisation has been hampered by the large number of variables involved. Many individual studies, and some long ongoing experiments, have used costly metre-class telescopes to obtain data despite other experiments demonstrating that much more flexible and affordable small aperture telescopes may be suitable for the task. In addition, due to the highly time consuming and weather dependent nature of obtaining photometric observations, many studies have suffered from data sets of limited size, or relied upon simulations to support their claims. With this in mind, an experiment was conducted with the aim of determining the utility of small aperture telescopes for conducting broadband photometry of satellites for the purpose of non-resolved space object identification and characterisation. A 14 inch Celestron CG-14 telescope was used to gain multiple night-long, high temporal resolution data sets of six active geostationary satellites. The results of the experiment cast doubt on the efficacy of some of the previous approaches to obtaining and analysing photometric data. It was discovered that geostationary satellite lightcurves can vary to a greater degree than has generally been recognised, and colour ratios vary considerably with changes in the illumination/observation geometry, making it difficult to use colour for satellite discrimination. Evidence was also detected of variations in the spectral energy distribution of sunlight reflected off satellite surface materials, which could have implications for surface material characterisation and techniques that aim to separate satellite body and solar panel contributions to the total observed spectra.

  14. Navigation and control of large satellite formations

    NASA Astrophysics Data System (ADS)

    Bamford, William Alfred, Jr.

    In recent years, there has been substantial interest in autonomous satellite formations, driven by the new technologies that enable smaller and cheaper spacecraft. Formation flying allows for mission designs, such as stereoscopic imaging, that are impractical or impossible for a single satellite. Much of the current work focuses upon small formations, which can be defined as four or less satellites in a relatively tight grouping. Next generation formations may be composed of more satellites spanning greater spatial distances. The large formation problem becomes more difficult for several reasons, including an increased amount of communication required between the satellites, and orbit perturbations, which become more important as the formation size grows. The purpose of this dissertation is to examine formation flying for large formations, and determine whether or not generalizations can be made linking the large and small formation regimes. In order to model formations with many satellites, a simulation environment was constructed in which different observers, controllers, and formation architectures can be modelled. This dissertation focuses on a decentralized control scheme, but the software is general enough to accommodate a variety of control architectures. Validation of the large formation models is accomplished by initially modelling only a pair of satellites and comparing the results against those found in the literature. As a demonstration of the theoretical results, a real-time, closed-loop, hardware-in-the-loop simulation was constructed using GPS receivers as the measurement source. A large constellation, real-tune simulation system was developed that utilized the Internet to connect simulation equipment from research centers in different locations.

  15. Telemetry via satellites for raptor studies

    USGS Publications Warehouse

    Fuller, M.R.; Ellis, D.H.; Klugman, S.S.

    1993-01-01

    Monitoring animal movements by satellite was first ac complished in 1970 with an elk in Wyoming. The large size of early transmitter packages restricted their use to very large animals. Miniaturization of electronic components in the 1980s allowed application of satellite telemetry to large birds. Satellite transmitters have been tested with mixed results on geese, swans, petrels, bustards, eagles, and falcons. Dramatic weight reduction in the 1980s was quickly followed by tests of a variety of transmitter shapes on captive birds. Research on attachment methods helped in selecting those methods least likely to elicit adverse behavior. Wind tunnel experiments were conducted to produce more aerodynamically efficient PTT designs. Recently, the utility of satellite tracking has been demonstrated in studies of wandering albatrosses in the Indian Ocean, migrating Bewick's swans, bald eagles, and golden eagles. Two other studies demonstrated the feasibility of tracking cranes by satellite. The types of information from these techniques will be presented and cross-referenced to a poster display and demonstration.

  16. Orbit determination accuracies using satellite-to-satellite tracking

    NASA Technical Reports Server (NTRS)

    Vonbun, F. O.; Argentiero, P. D.; Schmid, P. E.

    1977-01-01

    The uncertainty in relay satellite sate is a significant error source which cannot be ignored in the reduction of satellite-to-satellite tracking data. Based on simulations and real data reductions, it is numerically impractical to use simultaneous unconstrained solutions to determine both relay and user satellite epoch states. A Bayesian or least squares estimation technique with an a priori procedure is presented which permits the adjustment of relay satellite epoch state in the reduction of satellite-to-satellite tracking data without the numerical difficulties introduced by an ill-conditioned normal matrix.

  17. The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review)

    PubMed Central

    BRIGGS, MICHAEL D.; BELL, PETER A.; PIROG, KATARZYNA A.

    2015-01-01

    Genetic skeletal diseases (GSDs) are an extremely diverse and complex group of rare genetic diseases that primarily affect the development and homeostasis of the osseous skeleton. There are more than 450 unique and well-characterised phenotypes that range in severity from relatively mild to severe and lethal forms. Although individually rare, as a group of related genetic diseases, GSDs have an overall prevalence of at least 1 per 4,000 children. Qualitative defects in cartilage structural proteins result in a broad spectrum of both recessive and dominant GSDs. This review focused on a disease spectrum resulting from mutations in the non-collagenous glycoproteins, cartilage oligomeric matrix protein (COMP) and matrilin-3, which together cause a continuum of phenotypes that are amongst the most common autosomal dominant GSDs. Pseudoachondroplasia (PSACH) and autosomal dominant multiple epiphyseal dysplasia (MED) comprise a disease spectrum characterised by varying degrees of disproportionate short stature, joint pain and stiffness and early-onset osteoarthritis. Over the past decade, the generation and deep phenotyping of a range of genetic mouse models of the PSACH and MED disease spectrum has allowed the disease mechanisms to be characterised in detail. Moreover, the generation of novel phenocopies to model specific disease mechanisms has confirmed the importance of endoplasmic reticulum (ER) stress and reduced chondrocyte proliferation as key modulators of growth plate dysplasia and reduced bone growth. Finally, new insight into related musculoskeletal complications (such as myopathy and tendinopathy) has also been gained through the in-depth analysis of targeted mouse models of the PSACH-MED disease spectrum. PMID:25824717

  18. Meteorological satellite accomplishments

    NASA Technical Reports Server (NTRS)

    Allison, L. J.; Arking, A.; Bandeen, W. R.; Shenk, W. E.; Wexler, R.

    1974-01-01

    The various types of meteorological satellites are enumerated. Vertical sounding, parameter extraction technique, and both macroscale and mesoscale meteorological phenomena are discussed. The heat budget of the earth-atmosphere system is considered, along with ocean surface and hydrology.

  19. Domestic Communication Satellites

    ERIC Educational Resources Information Center

    Horowitz, Andrew

    1974-01-01

    A discussion of the Federal Communications Commission's new policy on domestic satellites in light of our 1) military and economic history; 2) corporate interests; 3) citizen surveillance; and 4) media control. (HB)

  20. AUSSAT mobile satellite services

    NASA Technical Reports Server (NTRS)

    Nowland, Wayne L.; Wagg, Michael; Simpson, Daniel

    1988-01-01

    An overview of AUSSAT's planned mobile satellite system is given. The development program which is being undertaken to achieve the 1992 service date is described. Both business and technical aspects of the development program are addressed.

  1. Weather, land satellite sale

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    President Ronald Reagan announced on March 8 plans to sell to private industry the nation's land and meteorological remote-sensing satellites, including the responsibility for any future ocean-observing systems. According to the plan, the private firm successful in its bid to buy the five satellites would sell back to the government the data received by the satellites. The Reagan administration says the sale will save money and will put activities appropriate for commercial ventures into the commercial sector. Response to the announcement from scientists and congressmen has been anything but dulcet; one senator, in fact, charges that the Commerce Department and the corporation most likely to purchase the satellites are engaged in a ‘sweetheart deal.’

  2. Aiming a Satellite Dish.

    ERIC Educational Resources Information Center

    Zebrowski, Ernest, Jr.

    1988-01-01

    Develops a pair of equations for calculating the elevation and azimuth angles for the various satellites. Uses 3-dimensional vector difference calculations. Provides a practical example, figures, and table. (YP)

  3. Speckle imaging of satellites

    SciTech Connect

    Fitch, J.P.; Lawrence, T.W.; Goodman, D.M.; Johansson, E.M.

    1991-12-01

    We performed a series of experiments using the Air Force Optical Station`s 1.6 m telescope and a bare CCD detector to capture speckle images of various satellites. The speckle images were processed with bispectral techniques for recovering image Fourier phase as well as projection onto convex sets for recovering image Fourier magnitude from the projected autocorrelation. Results of imaging point stars and binaries are shown as a baseline assessment of our technique. We have reconstructed high quality images of numerous satellites and will show reconstructions of a very familiar satellite: the Hubble Space Telescope. To our knowledge, this is the first demonstration of the use of bare CCDs for speckle imaging of relatively bright objects such as artificial satellites. 8 refs.

  4. Speckle imaging of satellites

    SciTech Connect

    Fitch, J.P.; Lawrence, T.W.; Goodman, D.M.; Johansson, E.M.

    1991-12-01

    We performed a series of experiments using the Air Force Optical Station's 1.6 m telescope and a bare CCD detector to capture speckle images of various satellites. The speckle images were processed with bispectral techniques for recovering image Fourier phase as well as projection onto convex sets for recovering image Fourier magnitude from the projected autocorrelation. Results of imaging point stars and binaries are shown as a baseline assessment of our technique. We have reconstructed high quality images of numerous satellites and will show reconstructions of a very familiar satellite: the Hubble Space Telescope. To our knowledge, this is the first demonstration of the use of bare CCDs for speckle imaging of relatively bright objects such as artificial satellites. 8 refs.

  5. Trends In Satellite Communication

    NASA Technical Reports Server (NTRS)

    Poley, William A.; Stevens, Grady H.; Stevenson, Steven M.; Lekan, Jack; Arth, Clifford H.; Hollansworth, James E.; Miller, Edward F.

    1988-01-01

    Report assesses trends in satellite communication from present to year 2010. Examines restrictions imposed by limited spectrum resource and technology needs created by trends. Personal communications, orbiting switchboards, and videophones foreseen.

  6. Epos TCS Satellite Data

    NASA Astrophysics Data System (ADS)

    Manunta, Michele; Mandea, Mioara; Fernández-Turiel, José Luis; Stramondo, Salvatore; Wright, Tim; Walter, Thomas; Bally, Philippe; Casu, Francesco; Zeni, Giovanni; Buonanno, Sabatino; Zinno, Ivana; Tizzani, Pietro; Castaldo, Raffaele; Ostanciaux, Emilie; Diament, Michel; Hooper, Andy; Maccaferri, Francesco; Lanari, Riccardo

    2016-04-01

    TCS Satellite Data is devoted to provide Earth Observation (EO) services, transversal with respect to the large EPOS community, suitable to be used in several application scenarios. In particular, the main goal is to contribute with mature services that have already well demonstrated their effectiveness and relevance in investigating the physical processes controlling earthquakes, volcanic eruptions and unrest episodes as well as those driving tectonics and Earth surface dynamics. The TCS Satellite Data will provide two kinds of services: satellite products/services, and Value-added satellite products/services. The satellite products/services are composed of three (EPOSAR, GDM and COMET) well-identified and partly already operational elements for delivering Level 1 products. Such services will be devoted to the generation of SAR interferograms, DTM and ground displacement maps through the exploitation of different advanced EO techniques for InSAR and optical data analysis. The Value-added satellite products/services are composed of 4 elements (EPOSAR, 3D-Def, Mod and COMET) of Level 2 and 3 products. Such services integrate satellite and in situ measurements and observations to retrieve information on source mechanism, such as the geometry (spatial location, depth, volume changes) and the physical parameters of the deformation sources, through the exploitation of modelling approaches. The TCS Satellite Data will provide products in two different processing and delivery modes: 1- surveillance mode - routinely product generation; 2- on demand mode - product generation performed on demand by the user. Concerning the surveillance mode, the goal is providing continuous satellite measurements in areas of particular interest from a geophysical perspective (supersites). The objective is the detection of displacement patterns changing along time and their geophysical explanation. This is a valid approach for inter-seismic movements and volcanic unrest, post-seismic and post

  7. Donor satellite cell engraftment is significantly augmented when the host niche is preserved and endogenous satellite cells are incapacitated.

    PubMed

    Boldrin, Luisa; Neal, Alice; Zammit, Peter S; Muntoni, Francesco; Morgan, Jennifer E

    2012-09-01

    Stem cell transplantation is already in clinical practice for certain genetic diseases and is a promising therapy for dystrophic muscle. We used the mdx mouse model of Duchenne muscular dystrophy to investigate the effect of the host satellite cell niche on the contribution of donor muscle stem cells (satellite cells) to muscle regeneration. We found that incapacitation of the host satellite cells and preservation of the muscle niche promote donor satellite cell contribution to muscle regeneration and functional reconstitution of the satellite cell compartment. But, if the host niche is not promptly refilled, or is filled by competent host satellite cells, it becomes nonfunctional and donor engraftment is negligible. Application of this regimen to aged host muscles also promotes efficient regeneration from aged donor satellite cells. In contrast, if the niche is destroyed, yet host satellite cells remain proliferation-competent, donor-derived engraftment is trivial. Thus preservation of the satellite cell niche, concomitant with functional impairment of the majority of satellite cells within dystrophic human muscles, may improve the efficiency of stem cell therapy.

  8. Geologic investigations of outer planets satellites

    NASA Technical Reports Server (NTRS)

    Strom, R. G.

    1984-01-01

    Four tests are examined: (1) investigation of volcanism on Io; Interim results of thermal and structural modeling of volcanism on Io are presented, (2) a study of the ancient heavily cratered regions on Ganymede, (3) a geologic comparison of the cratering record on Ganymede and Callisto, and (4) a geological and chemical investigation of internal resurfacing processes on the Saturnian satellites. Tasks 2, 3, and 4 utilize Voyager imaging data.

  9. Intersatellite link application to commercial communications satellites

    NASA Technical Reports Server (NTRS)

    Lee, Young S.; Atia, Ali E.; Ponchak, Denise S.

    1988-01-01

    The fundamental characteristics of intersatellite link (ISL) systems, and their application to domestic, regional, and global satellite communications, are described. The quantitative advantages of using ISLs to improve orbit utilization, spectrum occupancy, transmission delay (compared to multi-hop links), coverage, and connectivity, and to reduce the number of earth station antennas, are also presented. Cost-effectiveness and other systems benefits of using ISLs are identified, and the technical and systems planning aspects of ISL systems implementation are addressed.

  10. Servicing communication satellites in geostationary orbit

    NASA Technical Reports Server (NTRS)

    Russell, Paul K.; Price, Kent M.

    1990-01-01

    The econmic benefits of a LEO space station are quantified by identifying alternative operating scenarios utilizing the space station's transportation facilities and assembly and repair facilities. Particular consideration is given to the analysis of the impact of on-orbit assembly and servicing on a typical communications satellite is analyzed. The results of this study show that on-orbit servicing can increase the internal rate of return by as much as 30 percent.

  11. Satellite Applications for Public Service: Project Summaries.

    ERIC Educational Resources Information Center

    Lauffer, Sandra; And Others

    Summaries of 18 different projects involving the use of satellite communications are presented in this report, including PEACESAT Education and Communication Experiments, USP Network Satellite Communication Project, Project Satellite, Satellite Instructional Television Experiment (SITE), Appalachian Education Satellite Program, Alaska Education…

  12. Direct Broadcasting Satellites in Japan.

    ERIC Educational Resources Information Center

    Maeda, Jiro

    The development and use of broadcasting satellites in Japan are discussed in this paper. The paper describes the medium-scale experimental broadcasting satellite, YURI, launched by NASA in 1978, and reports that experiments with YURI in the areas of basic technologies in the broadcasting satellite system, experiments on satellite control…

  13. Satellite Technologies in the Classroom.

    ERIC Educational Resources Information Center

    Portz, Stephen M.

    1999-01-01

    Focuses on ways of using satellite imagery obtained from the Internet, to enhance classroom learning. Discusses satellite deployment; classroom applications, including infrared imagery, high-resolution photography, and global positioning satellites; and use of satellite data for hands-on activities, including cartography, city and community…

  14. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.

    PubMed

    Kano, S; Yuan, M; Cardarelli, R A; Maegawa, G; Higurashi, N; Gaval-Cruz, M; Wilson, A M; Tristan, C; Kondo, M A; Chen, Y; Koga, M; Obie, C; Ishizuka, K; Seshadri, S; Srivastava, R; Kato, T A; Horiuchi, Y; Sedlak, T W; Lee, Y; Rapoport, J L; Hirose, S; Okano, H; Valle, D; O'Donnell, P; Sawa, A; Kai, M

    2015-01-01

    Methodologies for generating functional neuronal cells directly from human fibroblasts [induced neuronal (iN) cells] have been recently developed, but the research so far has only focused on technical refinements or recapitulation of known pathological phenotypes. A critical question is whether this novel technology will contribute to elucidation of novel disease mechanisms or evaluation of therapeutic strategies. Here we have addressed this question by studying Tay-Sachs disease, a representative lysosomal storage disease, and Dravet syndrome, a form of severe myoclonic epilepsy in infancy, using human iN cells with feature of immature postmitotic glutamatergic neuronal cells. In Tay-Sachs disease, we have successfully characterized canonical neuronal pathology, massive accumulation of GM2 ganglioside, and demonstrated the suitability of this novel cell culture for future drug screening. In Dravet syndrome, we have identified a novel functional phenotype that was not suggested by studies of classical mouse models and human autopsied brains. Taken together, the present study demonstrates that human iN cells are useful for translational neuroscience research to explore novel disease mechanisms and evaluate therapeutic compounds. In the future, research using human iN cells with well-characterized genomic landscape can be integrated into multidisciplinary patient-oriented research on neuropsychiatric disorders to address novel disease mechanisms and evaluate therapeutic strategies.

  15. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.

    PubMed

    Kano, S; Yuan, M; Cardarelli, R A; Maegawa, G; Higurashi, N; Gaval-Cruz, M; Wilson, A M; Tristan, C; Kondo, M A; Chen, Y; Koga, M; Obie, C; Ishizuka, K; Seshadri, S; Srivastava, R; Kato, T A; Horiuchi, Y; Sedlak, T W; Lee, Y; Rapoport, J L; Hirose, S; Okano, H; Valle, D; O'Donnell, P; Sawa, A; Kai, M

    2015-01-01

    Methodologies for generating functional neuronal cells directly from human fibroblasts [induced neuronal (iN) cells] have been recently developed, but the research so far has only focused on technical refinements or recapitulation of known pathological phenotypes. A critical question is whether this novel technology will contribute to elucidation of novel disease mechanisms or evaluation of therapeutic strategies. Here we have addressed this question by studying Tay-Sachs disease, a representative lysosomal storage disease, and Dravet syndrome, a form of severe myoclonic epilepsy in infancy, using human iN cells with feature of immature postmitotic glutamatergic neuronal cells. In Tay-Sachs disease, we have successfully characterized canonical neuronal pathology, massive accumulation of GM2 ganglioside, and demonstrated the suitability of this novel cell culture for future drug screening. In Dravet syndrome, we have identified a novel functional phenotype that was not suggested by studies of classical mouse models and human autopsied brains. Taken together, the present study demonstrates that human iN cells are useful for translational neuroscience research to explore novel disease mechanisms and evaluate therapeutic compounds. In the future, research using human iN cells with well-characterized genomic landscape can be integrated into multidisciplinary patient-oriented research on neuropsychiatric disorders to address novel disease mechanisms and evaluate therapeutic strategies. PMID:25732146

  16. Space Solar Power Satellite Systems, Modern Small Satellites, and Space Rectenna

    NASA Astrophysics Data System (ADS)

    Bergsrud, Corey Alexis Marvin

    Space solar power satellite (SSPS) systems is the concept of placing large satellite into geostationary Earth orbit (GEO) to harvest and convert massive amounts of solar energy into microwave energy, and to transmit the microwaves to a rectifying antenna (rectenna) array on Earth. The rectenna array captures and converts the microwave power into usable power that is injected into the terrestrial electric grid for use. This work approached the microwave power beam as an additional source of power (with solar) for lower orbiting satellites. Assuming the concept of retrodirectivity, a GEO-SSPS antenna array system tracks and delivers microwave power to lower orbiting satellites. The lower orbiting satellites are equipped with a stacked photovoltaic (PV)/rectenna array hybrid power generation unit (HPGU) in order to harvest solar and/or microwave energy for on-board use during orbit. The area, and mass of the PV array part of the HPGU was reduced at about 32% beginning-of-life power in order to achieve the spacecraft power requirements. The HPGU proved to offer a mass decrease in the PGU, and an increase in mission life due to longer living component life of the rectenna array. Moreover, greater mission flexibility is achieved through a track and power delivery concept. To validate the potential advantages offered by a HPGU, a mission concept was presented that utilizes modern small satellites as technology demonstrators. During launch, a smaller power receiving "daughter" satellite sits inside a larger power transmitting "mother" satellite. Once separated from the launch vehicle the daughter satellite is ejected away from the mother satellite, and each satellite deploys its respective power transmitting or power receiving hardware's for experimentation. The concept of close proximity mission operations between the satellites is considered. To validate the technology of the space rectenna array part of the HPGU, six milestones were completed in the design. The first

  17. ESTL tracking and data relay satellite /TDRSS/ simulation system

    NASA Technical Reports Server (NTRS)

    Kapell, M. H.

    1980-01-01

    The Tracking Data Relay Satellite System (TDRSS) provides single access forward and return communication links with the Shuttle/Orbiter via S-band and Ku-band frequency bands. The ESTL (Electronic Systems Test Laboratory) at Lyndon B. Johnson Space Center (JSC) utilizes a TDRS satellite simulator and critical TDRS ground hardware for test operations. To accomplish Orbiter/TDRSS relay communications performance testing in the ESTL, a satellite simulator was developed which met the specification requirements of the TDRSS channels utilized by the Orbiter. Actual TDRSS ground hardware unique to the Orbiter communication interfaces was procured from individual vendors, integrated in the ESTL, and interfaced via a data bus for control and status monitoring. This paper discusses the satellite simulation hardware in terms of early development and subsequent modifications. The TDRS ground hardware configuration and the complex computer interface requirements are reviewed. Also, special test hardware such as a radio frequency interference test generator is discussed.

  18. Satellite Meteorology Education Resources Freely Available from COMET°

    NASA Astrophysics Data System (ADS)

    Abshire, W. E.; Dills, P. N.

    2011-12-01

    The COMET° Program (www.comet.ucar.edu) receives funding from NOAA NESDIS, EUMETSAT, and the Meteorological Service of Canada to support education and training efforts in satellite meteorology. These partnerships enable COMET to create educational materials of global interest on the application of products from geostationary and polar-orbiting remote sensing platforms. Recently, COMET's satellite education programs have focused on both current and next generation satellites and their relevance to operational forecasters and other communities. By partnering with experts from the Naval Research Laboratory, NOAA-NESDIS and its Cooperative Institutes, MSC, and other user communities, COMET stimulates greater utilization of satellite data and products. COMET also continues to broaden the scope of its training to include materials on the EUMETSAT Polar-orbiting System (EPS) and Meteosat geostationary satellites. EPS represents an important contribution to the Initial Joint Polar System between NOAA and EUMETSAT, while Meteosat Second Generation imaging capabilities provide an authentic proving ground for the next-generation GOES-R imager. This presentation provides an overview of COMET's recent satellite education efforts including courses and publications that focus on topics like multispectral RGB products, detecting atmospheric dust, and climate monitoring from satellites. Over 50 satellite-focused self-paced online materials are freely available via the Satellite Topic area of the MetEd Web site (www.meted.ucar.edu/topics/modules/satellite) and COMET's Environmental Satellite Resource Center (ESRC)(www.meted.ucar.edu/esrc). The ESRC, another important resource developed for use by the geosciences and education communities, is a searchable, database driven Web site that provides easy access to a wide range of useful information and training materials on Earth-observing satellites. Simple free online registration is required to access all training materials and the

  19. Cyber security with radio frequency interferences mitigation study for satellite systems

    NASA Astrophysics Data System (ADS)

    Wang, Gang; Wei, Sixiao; Chen, Genshe; Tian, Xin; Shen, Dan; Pham, Khanh; Nguyen, Tien M.; Blasch, Erik

    2016-05-01

    Satellite systems including the Global Navigation Satellite System (GNSS) and the satellite communications (SATCOM) system provide great convenience and utility to human life including emergency response, wide area efficient communications, and effective transportation. Elements of satellite systems incorporate technologies such as navigation with the global positioning system (GPS), satellite digital video broadcasting, and information transmission with a very small aperture terminal (VSAT), etc. The satellite systems importance is growing in prominence with end users' requirement for globally high data rate transmissions; the cost reduction of launching satellites; development of smaller sized satellites including cubesat, nanosat, picosat, and femtosat; and integrating internet services with satellite networks. However, with the promising benefits, challenges remain to fully develop secure and robust satellite systems with pervasive computing and communications. In this paper, we investigate both cyber security and radio frequency (RF) interferences mitigation for satellite systems, and demonstrate that they are not isolated. The action space for both cyber security and RF interferences are firstly summarized for satellite systems, based on which the mitigation schemes for both cyber security and RF interferences are given. A multi-layered satellite systems structure is provided with cross-layer design considering multi-path routing and channel coding, to provide great security and diversity gains for secure and robust satellite systems.

  20. Satellite Communications for ATM

    NASA Technical Reports Server (NTRS)

    Shamma, Mohammed A.

    2003-01-01

    This presentation is an overview on Satellite Communication for the Aeronautical Telecommunication Management (ATM) research. Satellite Communications are being considered by the FAA and NASA as a possible alternative to the present and future ground systems supporting Air Traffic Communications. The international Civil Aviation Organization (ICAO) have in place Standards and Recommended Practices (SARPS) for the Aeronautical Mobile Satellite Services (AMSS) which is mainly derived from the pre-existing Inmarsat service that has been in service since the 1980s. The Working Group A of the Aeronautical Mobile Communication Panel of ICAO has also been investigating SARPS for what is called the Next Generation Satellite Service (NGSS) which conforms less to the Inmarsat based architecture and explores wider options in terms of satellite architectures. Several designs are being proposed by Firms such as Boeing, ESA, NASA that are geared toward full or secondary usage of satellite communications for ATM. Satellite communications for ATM can serve several purposes ranging from primary usage where ground services would play a minimal backup role, to an integrated solution where it will be used to cover services, or areas that are less likely to be supported by the proposed and existing ground infrastructure. Such Integrated roles can include usage of satellite communications for oceanic and remote land areas for example. It also can include relieving the capacity of the ground network by providing broadcast based services of Traffic Information Services messages (TIS-B), or Flight Information Services (FIS-B) which can take a significant portion of the ground system capacity. Additionally, satellite communication can play a backup role to support any needs for ground replacement, or additional needed capacity even after the new digital systems are in place. The additional bandwidth that can be provided via satellite communications can also open the door for many new

  1. Vibration and acoustic testing of TOPEX/Poseidon satellite

    NASA Technical Reports Server (NTRS)

    Boatman, Dave; Scharton, Terry; Hershfeld, Donald; Larkin, Paul

    1992-01-01

    The satellite was subjected to a 1.5G swept sine vibration test and a 146 dB overall level acoustic test, in accordance with Ariane launch vehicle requirements, at the NASA Goddard Space Flight Center. Extensive pretest analysis of the sine test was conducted to plan the input notching and to justify vibration testing the satellite only in the longitudinal axis. A unique measurement system was utilized to determine the six components of interface force between the shaker and the satellite in the sine vibration test. The satellite was heavily instrumented in both the sine vibration and acoustic test in order to insure that the launch loads were enveloped with appropriate margin and that satellite responses did not exceed the compatibilities of the structure and equipment. The test specification, objectives, instrumentation, and test results are described herein.

  2. 42 CFR 456.614 - Inspections by utilization review committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Inspections of Care in Intermediate Care Facilities and Institutions for Mental Diseases § 456.614 Inspections by utilization...

  3. 42 CFR 456.614 - Inspections by utilization review committee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Inspections of Care in Intermediate Care Facilities and Institutions for Mental Diseases § 456.614 Inspections by utilization...

  4. 42 CFR 456.614 - Inspections by utilization review committee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Inspections of Care in Intermediate Care Facilities and Institutions for Mental Diseases § 456.614 Inspections by utilization...

  5. 42 CFR 456.614 - Inspections by utilization review committee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Inspections of Care in Intermediate Care Facilities and Institutions for Mental Diseases § 456.614 Inspections by utilization...

  6. Satellite services system analysis study. Volume 5: Programmatics

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The overall program and resources needed for development and operation of a Satellite Services System is reviewed. Program requirements covered system operations through 1993 and were completed in preliminary form. Program requirements were refined based on equipment preliminary design and analysis. Schedules, costs, equipment utilization, and facility/advanced technology requirements were included in the update. Equipment user charges were developed for each piece of equipment and for representative satellite servicing missions.

  7. Technical and economic feasibility of integrated video service by satellite

    NASA Technical Reports Server (NTRS)

    Price, K. M.; Kwan, R. K.; White, L. W.; Garlow, R. K.; Henderson, T. R.

    1992-01-01

    A feasibility study is presented of utilizing modern satellite technology, or more advanced technology, to create a cost-effective, user-friendly, integrated video service, which can provide videophone, video conference, or other equivalent wideband service on demand. A system is described that permits a user to select a desired audience and establish the required links similar to arranging a teleconference by phone. Attention is given to video standards, video traffic scenarios, satellite system architecture, and user costs.

  8. Utility of a mHealth App for Self-Management and Education of Cardiac Diseases in Spanish Urban and Rural Areas.

    PubMed

    de Garibay, Valentín González; Fernández, Miguel A; de la Torre-Díez, Isabel; López-Coronado, Miguel

    2016-08-01

    Analyze the utility of a mobile health app named HeartKeeper in several groups of population and obtain conclusions to be applied to other similar apps. A questionnaire has been designed to evaluate the usage and utility of the HeartKeeper app. The questionnaire information was collected by collaborating cardiologists from 32 patients before and after they used the app. Patients were randomly selected with established quotas within interest groups, so that men and women, patients older or younger than 60 years old and patients living in urban or rural areas were equally represented. Using the appropriate statistical techniques we see that the HeartKeeper app was useful for patients as they qualify with 70 points (out of 100) the overall opinion of the app, it helps them remember more easily taking their pills with a mean improvement of 20.94 points (p < 0.001) and they perceive a global improvement of their health (8.28 points, p < 0.001). We also observe that these improvements do not depend, in general, on the area (urban or rural) where the patient comes from or on their sex. Although older patients needed more help to use the app and used it slightly less frequently, the improvements on several measures considered, such as remembering taking pills, breathing problems or trouble developing activities, depend significantly (p < 0.05) on age with older patients reporting higher improvements than younger ones. The results obtained with the sample of patients considered in this research prove the utility of the HeartKeeper app. This utility is similar in urban and rural areas and for patients of both sexes and, to some extent, depends on the age of the patient with older patients reporting slightly lower frequency of use but higher health improvements than younger ones. PMID:27329050

  9. Utility of a mHealth App for Self-Management and Education of Cardiac Diseases in Spanish Urban and Rural Areas.

    PubMed

    de Garibay, Valentín González; Fernández, Miguel A; de la Torre-Díez, Isabel; López-Coronado, Miguel

    2016-08-01

    Analyze the utility of a mobile health app named HeartKeeper in several groups of population and obtain conclusions to be applied to other similar apps. A questionnaire has been designed to evaluate the usage and utility of the HeartKeeper app. The questionnaire information was collected by collaborating cardiologists from 32 patients before and after they used the app. Patients were randomly selected with established quotas within interest groups, so that men and women, patients older or younger than 60 years old and patients living in urban or rural areas were equally represented. Using the appropriate statistical techniques we see that the HeartKeeper app was useful for patients as they qualify with 70 points (out of 100) the overall opinion of the app, it helps them remember more easily taking their pills with a mean improvement of 20.94 points (p < 0.001) and they perceive a global improvement of their health (8.28 points, p < 0.001). We also observe that these improvements do not depend, in general, on the area (urban or rural) where the patient comes from or on their sex. Although older patients needed more help to use the app and used it slightly less frequently, the improvements on several measures considered, such as remembering taking pills, breathing problems or trouble developing activities, depend significantly (p < 0.05) on age with older patients reporting higher improvements than younger ones. The results obtained with the sample of patients considered in this research prove the utility of the HeartKeeper app. This utility is similar in urban and rural areas and for patients of both sexes and, to some extent, depends on the age of the patient with older patients reporting slightly lower frequency of use but higher health improvements than younger ones.

  10. Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure.

    PubMed

    Cantonwine, David E; Ferguson, Kelly K; Mukherjee, Bhramar; Chen, Yin-Hsiu; Smith, Nicole A; Robinson, Julian N; Doubilet, Peter M; Meeker, John D; McElrath, Thomas F

    2016-01-01

    Impaired or suboptimal fetal growth is associated with an increased risk of perinatal morbidity and mortality. By utilizing readily available clinical data on the relative size of the fetus at multiple points in pregnancy, including delivery, future epidemiological research can improve our understanding of the impacts of maternal, fetal, and environmental factors on fetal growth at different windows during pregnancy. This study presents mean and standard deviation ultrasound measurements from a clinically representative US population that can be utilized for creating Z-scores to this end. Between 2006 and 2012, 18, 904 non-anomalous pregnancies that received prenatal care, first and second trimester ultrasound evaluations, and ultimately delivered singleton newborns at Brigham and Women's hospital in Boston were used to create the standard population. To illustrate the utility of this standard, we created Z-scores for ultrasound and delivery measurements for a cohort study population and examined associations with factors known to be associated with fetal growth. In addition to cross-sectional regression models, we created linear mixed models and generalized additive mixed models to illustrate how these scores can be utilized longitudinally and for the identification of windows of susceptibility. After adjustment for a priori confounders, maternal BMI was positively associated with increased fetal size beginning in the second trimester in cross-sectional models. Female infants and maternal smoking were associated with consistently reduced fetal size in the longitudinal models. Maternal age had a non-significant association with increased size in the first trimester that was attenuated as gestation progressed. As the growth measurements examined here are widely available in contemporary obstetrical practice, these data may be abstracted from medical records by investigators and standardized with the population means presented here. This will enable easy extension of

  11. Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure

    PubMed Central

    Cantonwine, David E.; Ferguson, Kelly K.; Mukherjee, Bhramar; Chen, Yin-Hsiu; Smith, Nicole A.; Robinson, Julian N.; Doubilet, Peter M.; Meeker, John D.; McElrath, Thomas F.

    2016-01-01

    Impaired or suboptimal fetal growth is associated with an increased risk of perinatal morbidity and mortality. By utilizing readily available clinical data on the relative size of the fetus at multiple points in pregnancy, including delivery, future epidemiological research can improve our understanding of the impacts of maternal, fetal, and environmental factors on fetal growth at different windows during pregnancy. This study presents mean and standard deviation ultrasound measurements from a clinically representative US population that can be utilized for creating Z-scores to this end. Between 2006 and 2012, 18, 904 non-anomalous pregnancies that received prenatal care, first and second trimester ultrasound evaluations, and ultimately delivered singleton newborns at Brigham and Women’s hospital in Boston were used to create the standard population. To illustrate the utility of this standard, we created Z-scores for ultrasound and delivery measurements for a cohort study population and examined associations with factors known to be associated with fetal growth. In addition to cross-sectional regression models, we created linear mixed models and generalized additive mixed models to illustrate how these scores can be utilized longitudinally and for the identification of windows of susceptibility. After adjustment for a priori confounders, maternal BMI was positively associated with increased fetal size beginning in the second trimester in cross-sectional models. Female infants and maternal smoking were associated with consistently reduced fetal size in the longitudinal models. Maternal age had a non-significant association with increased size in the first trimester that was attenuated as gestation progressed. As the growth measurements examined here are widely available in contemporary obstetrical practice, these data may be abstracted from medical records by investigators and standardized with the population means presented here. This will enable easy extension

  12. Utilization of satellite data for inventorying prairie ponds and lakes

    NASA Technical Reports Server (NTRS)

    Work, E. A., Jr.; Gilmer, D. S.

    1976-01-01

    ERTS-1 data were used in mapping open surface water features in the glaciated prairies. Emphasis was placed on the recognition of these features based upon water's uniquely low radiance in a single near-infrared waveband. On the basis of these results, thematic maps and statistics relating to open surface water were obtained. In a related effort, the added information content of multiple spectral wavebands was used for discriminating surface water at a level of detail finer than the virtual resolution of the data. The basic theory of this technique and some preliminary results are described.

  13. Institutional arrangements. [utilization of information derived from satellites

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The practical application of space systems is considered in terms of institutional arrangements. The evolution of space systems is examined along with examples of institutional arrangements for space systems uses or applications. An institutional framework developed to assure the widest practicable application of space system is proposed and described. Recommendations are included.

  14. Potential utility of future satellite magnetic field data

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The requirements for a program of geomagnetic field studies are examined which will satisfy a wide range of user needs in the interim period between now and the time at which data from the Geopotential Research Mission (GRM) becomes available, and the long term needs for NASA's program in this area are considered. An overview of the subject, a justification for the recommended activities in the near term and long term, and a summary of the recommendations reached by the contributors is included.

  15. The utility of the model for end-stage liver disease score: a reliable guide for liver transplant candidacy and, for select patients, simultaneous hospice referral.

    PubMed

    Medici, Valentina; Rossaro, Lorenzo; Wegelin, Jacob A; Kamboj, Amit; Nakai, Junko; Fisher, Kelli; Meyers, Frederick J

    2008-08-01

    Patients with chronic liver disease are referred late to hospice or never referred. There are several barriers to timely referral. First, liver transplantation (LT) and hospice care have always been perceived as mutually exclusive. Yet the criteria for hospice referral and for LT are more similar than different (for example, advanced liver disease and imminent death). Second, physicians, patients, and families have not had a reliable metric to guide referral. However, many patients wait for transplantation but never receive an organ. We hypothesized that the Model for End-Stage Liver Disease (MELD) score already in use to prioritize LT could be used in selected patients for concurrent hospice referral. Furthermore, we hypothesized that patients awaiting LT can receive hospice care and remain eligible for transplantation. Patients with advanced or end-stage liver disease were referred to the University of California Davis Health System hospice program. We correlated the MELD score at admission to length of stay (LOS) in hospice. A total of 157 end-stage liver disease patients were admitted to the hospice service. At the time of hospice admission the mean MELD score was 21 (range, 6-45). The mean length of hospice stay was 38 days (range, 1-329 days). A significant correlation was observed between hospice LOS and MELD score at hospice admission (P < 0.01). Six patients were offered a liver graft while on the combined (LT and hospice) program. MELD can be used to guide clinician recommendation to families about hospice care, achieving one of the national benchmark goals of increasing hospice care duration beyond the current median of 2-3 weeks. A higher MELD score might augment physician judgment as to hospice referral. Hospice care for selected patients may be an effective strategy to improve the care of end-stage liver disease patients waiting for LT. PMID:18668666

  16. Next generation communications satellites: multiple access and network studies

    NASA Technical Reports Server (NTRS)

    Meadows, H. E.; Schwartz, M.; Stern, T. E.; Ganguly, S.; Kraimeche, B.; Matsuo, K.; Gopal, I.

    1982-01-01

    Efficient resource allocation and network design for satellite systems serving heterogeneous user populations with large numbers of small direct-to-user Earth stations are discussed. Focus is on TDMA systems involving a high degree of frequency reuse by means of satellite-switched multiple beams (SSMB) with varying degrees of onboard processing. Algorithms for the efficient utilization of the satellite resources were developed. The effect of skewed traffic, overlapping beams and batched arrivals in packet-switched SSMB systems, integration of stream and bursty traffic, and optimal circuit scheduling in SSMB systems: performance bounds and computational complexity are discussed.

  17. Communication satellite technology: State of the art and development opportunities

    NASA Technical Reports Server (NTRS)

    Woodford, J. B. (Compiler)

    1978-01-01

    Opportunities in communication satellite technology are identified and defined. Factors that tend to limit the ready availability of satellite communication to an increasingly wide group of users are evaluated. Current primary limitations on this wide utilization are the availability of frequency and/or synchronous equatorial satellite positions and the cost of individual user Earth terminals. The former could be ameliorated through the reuse of frequencies, the use of higher frequency bands, and the reduction of antenna side lobes. The latter limitation requires innovative hardware, design, careful system design, and large scale production.

  18. Optimal Constellation Design for Satellite Based Augmentation System

    NASA Astrophysics Data System (ADS)

    Kawano, Isao

    Global Positioning System (GPS) is widely utilized in daily life, for instance car navigation. Wide Area Augmentation System (WAAS) and Local Area Augmentation System (LAAS) are proposed so as to provide GPS better navigation accuracy and integrity capability. Satellite Based Augmentation System (SBAS) is a kind of WAAS and Multi-functional Transportation Satellite (MTSAT) has been developed in Japan. To improve navigation accuracy most efficiently, augmentation satellites should be so placed that minimize Geometric Dilution of Precision (GDOP) of constellation. In this paper the result of optimal constellation design for SBAS is shown.

  19. Satellite cluster flight using on-off cyclic control

    NASA Astrophysics Data System (ADS)

    Zhang, Hao; Gurfil, Pini

    2015-01-01

    Nano-satellite clusters and disaggregated satellites are new concepts in the realm of distributed satellite systems, which require complex cluster management - mainly regulating the maximal and minimal inter-satellite distances on time scales of years - while utilizing simple on-off propulsion systems. The simple actuators and long time scales require judicious astrodynamical modeling coupled with specialized orbit control. This paper offers a satellite cluster orbit control law which works for long time scales in a perturbed environment while utilizing fixed-magnitude thrusters. The main idea is to design a distributed controller which balances the fuel consumption among the satellites, thus mitigating the effect of differential drag perturbations. The underlying methodology utilizes a cyclic control algorithm based on a mean orbital elements feedback. Stability properties of the closed-loop cyclic control system do not adhere to the classical Lyapunov stability theory, so an effort is made to define and implement a suitable stability theory of noncompact equilibria sets. A state selection scheme is proposed for efficiently establishing a low Earth orbit cluster. Several simulations, including a real mission study, and several comparative investigations, are performed to show the strengths of the proposed control law.

  20. High performance satellite networks

    NASA Astrophysics Data System (ADS)

    Helm, Neil R.; Edelson, Burton I.

    1997-06-01

    The high performance satellite communications networks of the future will have to be interoperable with terrestrial fiber cables. These satellite networks will evolve from narrowband analogue formats to broadband digital transmission schemes, with protocols, algorithms and transmission architectures that will segment the data into uniform cells and frames, and then transmit these data via larger and more efficient synchronous optional (SONET) and asynchronous transfer mode (ATM) networks that are being developed for the information "superhighway". These high performance satellite communications and information networks are required for modern applications, such as electronic commerce, digital libraries, medical imaging, distance learning, and the distribution of science data. In order for satellites to participate in these information superhighway networks, it is essential that they demonstrate their ability to: (1) operate seamlessly with heterogeneous architectures and applications, (2) carry data at SONET rates with the same quality of service as optical fibers, (3) qualify transmission delay as a parameter not a problem, and (4) show that satellites have several performance and economic advantages over fiber cable networks.

  1. Satellite altimeter calibration techniques

    NASA Technical Reports Server (NTRS)

    Kolenkiewicz, R.; Martin, C. F.

    1990-01-01

    This paper examines calibration techniques which can most effectively satisfy the requirements of future satellites carrying high-accuracy radar altimeters, such as the ESA ERS-1 and the NASA/CNES Topex/Poseidon satellites scheduled for launch during the next five years. The calibration accuracies and the advantages and disadvantages of the four currently proposed calibration techniques for over-water calibration are discussed: (1) a tide gauge on a tower at-sea and a nearby laser, (2) a laser and a tide gauge on an island with an offshore satellite pass and a geoid tie between the satellite ground track and the laser, (3) a tide gauge on a tower at-sea with satellite positioning from multiple lasers and a GPS, and (4) a laser and a tide gauge on a tower at-sea. Error budgets for these techniques, developed on the basis of state-of-the-art tracking systems, were found to have one sigma height uncertainties in the 2.8 to 4.9 cm range.

  2. Comparing Two Satellite Sensors

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This pair of images shows the same area of South Africa's Kruger National Park taken by different satellite sensors only minutes apart. The top image is from the Enhanced Thematic Mapper plus (ETM+) aboard Landsat 7, the latest in a long line of high-resolution remote sensing satellites begun in 1972 with the Earth Resources Technology Satellite (ERTS), later renamed Landsat-1. The bottom image was acquired by the Advanced Land Imager (ALI) aboard Earth Observer-1 (EO-1), an instrument designed to test new technologies that will continue the observations begun by the Landsat satellites. Future instruments like the ALI will be much smaller and less expensive than the ETM+, enabling NASA and the United States Geological Survey (USGS) to continue exploring the surface of the Earth. Both images above are false color composites combining short wave infrared (1.65 um), near infrared (.79 um), and green (.57 um) wavelengths as red, green, and blue, respectively. Dense vegetation appears green. The similarity of the images demonstrates the ability of the ALI to produce data that can be compared with the 29-year archive of Landsat data. Several NASA field campaigns conducted in Kruger National Park provided ground-based data needed to evaluate measurements from each of the satellite sensors. For more information, read the EO-1 fact sheet and the Landsat-7 fact sheet. Images courtesy Landsat 7 Science Team

  3. Satellite altimeter calibration techniques

    NASA Astrophysics Data System (ADS)

    Kolenkiewicz, R.; Martin, C. F.

    This paper examines calibration techniques which can most effectively satisfy the requirements of future satellites carrying high-accuracy radar altimeters, such as the ESA ERS-1 and the NASA/CNES Topex/Poseidon satellites scheduled for launch during the next five years. The calibration accuracies and the advantages and disadvantages of the four currently proposed calibration techniques for over-water calibration are discussed: (1) a tide gauge on a tower at-sea and a nearby laser, (2) a laser and a tide gauge on an island with an offshore satellite pass and a geoid tie between the satellite ground track and the laser, (3) a tide gauge on a tower at-sea with satellite positioning from multiple lasers and a GPS, and (4) a laser and a tide gauge on a tower at-sea. Error budgets for these techniques, developed on the basis of state-of-the-art tracking systems, were found to have one sigma height uncertainties in the 2.8 to 4.9 cm range.

  4. International communications via satellite

    NASA Astrophysics Data System (ADS)

    McLucas, J. L.

    The evolution of communications satellite systems is traced in terms of technical capabilities and technological advances. The Communications Act of 1962 led to the establishment of INTELSAT on an international basis in 1964. The original 19 signatory nations has grown to over 100, and over 800 ground relay stations have been built. The INTELSAT system comprises spacecraft over the Atlantic, Pacific, and Indian Oceans and handles 2/3 of the world's international electronic communications and all transoceanic television. The 1965 Early Bird satellite had a 240 two-way telephone link capacity and weighed 38 kg, while the Intelsat V satellites, of which there will be nine, have increased the capacity to 20,000 voice circuits and Intelsat VI will double the number by 1993. Increasing demand for satellite communications links is driving the design and development of space platforms for multiple missions of communications, meteorological studies, and on-board switching and data processing in excess of current multiple satellite systems.

  5. 3D timelapse analysis of muscle satellite cell motility.

    PubMed

    Siegel, Ashley L; Atchison, Kevin; Fisher, Kevin E; Davis, George E; Cornelison, D D W

    2009-10-01

    Skeletal muscle repair and regeneration requires the activity of satellite cells, a population of myogenic stem cells scattered throughout the tissue and activated to proliferate and differentiate in response to myotrauma or disease. While it seems likely that satellite cells would need to navigate local muscle tissue to reach damaged areas, relatively little data on such motility exist, and most studies have been with immortalized cell lines. We find that primary satellite cells are significantly more motile than myoblast cell lines, and that adhesion to laminin promotes primary cell motility more than fourfold over other substrates. Using timelapse videomicroscopy to assess satellite cell motility on single living myofibers, we have identified a requirement for the laminin-binding integrin alpha 7 beta 1 in satellite cell motility, as well as a role for hepatocyte growth factor in promoting directional persistence. The extensive migratory behavior of satellite cells resident on muscle fibers suggests caution when determining, based on fixed specimens, whether adjacent cells are daughters from the same mother cell. We also observed more persistent long-term contact between individual satellite cells than has been previously supposed, potential cell-cell attractive and repulsive interactions, and migration between host myofibers. Based on such activity, we assayed for expression of "pathfinding" cues, and found that satellite cells express multiple guidance ligands and receptors. Together, these data suggest that satellite cell migration in vivo may be more extensive than currently thought, and could be regulated by combinations of signals, including adhesive haptotaxis, soluble factors, and guidance cues.

  6. Proposal of “Ig Satellite Design Contest” and Its Expected Effect

    NASA Astrophysics Data System (ADS)

    Sahara, Hironori; Hosoda, Satoshi; Sugawara, Yoshiki; Nakano, Masakatsu; Nakasuka, Shinichi

    This paper proposes to hold “Ig Satellite Design Contest,” in order to expand our space utilization by means of content-based satellites in the stream of recent microsatellite development. Going back to the history of the recent microsatellite, such a content-based satellite is positioned as the third-generation one. Ig Satellite Design Contest stands on the position of the two policies, that is, the satellite is chip in porridge for practical effect, but is to bring pleasure or happiness to people, or to stimulate access to the space and our future space activities.

  7. An advanced satellite communication system for ISDN subscriber and trunk applications - DYANET-II

    NASA Astrophysics Data System (ADS)

    Otsu, Toru; Umehira, Masahiro; Onuki, Masafumi; Nakashima, Hiroshi

    1992-03-01

    This paper describes an advanced satellite communication system for ISDN subscriber and trunk applications that is integrated into a terrestrial ISDN. The system concept of DYANET (DYnamic channel Assigning and routing satellite aided digital NETwork) has been extended to a new platform called DYANET-II which allows satellite communications to be applied to ISDN subscriber lines as well as trunk circuits. New network control technologies have been developed to achieve efficient satellite channel utilization and to ensure a single hop connection of a satellite channel without modifying existing networks. Moreover, compact earth station equipment has been newly developed for use on customer premises.

  8. Utilization of monoclonal-antibody-based assay (HemoCard in screening for and differentiating between genotypes of sickle cell disease and other hemoglobinopathies.

    PubMed

    Schultz, J C

    1995-01-01

    Sickle cell disease covers a group of conditions in which pathology may be attributed to the presence of sickle hemoglobin (HbS). The identification of HbS and other variants including those in combination with HbS is commonly achieved by cellulose acetate electrophoresis at alkaline pH. Because many hemoglobin variants with similar charges have similar electrophoretic migration patterns, they are difficult to differentiate by electrophoresis. The HemoCard assays address this concern through the use of monoclonal antibodies capable of specifically recognizing the unique amino acid substitution in the variant hemoglobin. The panel of HemoCard monoclonal antibodies confirms the absence and presence of HbA, HbC, HbE, HbS, and other sickling hemoglobin variants. The combination of alkaline cellulose acetate electrophoresis and HemoCard assays allows the technologist to reach a final conformation of both common and much less common sickle cell disease genotypes, combinations of HbS with other hemoglobins that ordinarily do not produce sickle cell disease, and other clinically important hemoglobinopathies including HbE/beta-thalassemia and hemoglobin C disease. PMID:8587004

  9. Selection of Variants Utilizing Heparin Sulphate For Cell Entry When South African Territories Foot-and-Mouth Disease Virus is Adapted for Growth on Cell Culture

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Foot-and-mouth disease virus (FMDV) attains entry to epithelial cells by affinity for at least four members of the integrin family of receptors. Adaptation of field isolates to grow in cultured cells is an essential step towards development of vaccines against new outbreak strains. This is made poss...

  10. Soviet satellite communications science and technology

    SciTech Connect

    Birch, J.N.; Campanella, S.J.; Gordon, G.D.; McElroy, D.R.; Pritchard, W.L.; Stamminger, R.

    1991-08-01

    This is a report by six US scientists and engineers concerning the current state of the art and projections of future Soviet satellite communications technologies. The panel members are experts in satellite stabilization, spacecraft environments, space power generation, launch systems, spacecraft communications sciences and technologies, onboard processing, ground stations, and other technologies that impact communications. The panel assessed the Soviet ability to support high-data-rate space missions at 128 Mbps by evaluating current and projected Soviet satellite communications technologies. A variety of space missions were considered, including Earth-to-Earth communications via satellites in geostationary or highly elliptical orbits, those missions that require space-to-Earth communications via a direct path and those missions that require space-to-Earth communications via a relay satellite. Soviet satellite communications capability, in most cases, is 10 years behind that of the United States and other industrialized nations. However, based upon an analysis of communications links needed to support these missions using current Soviet capabilities, it is well within the current Soviet technology to support certain space missions outlined above at rates of 128 Mbps or higher, although published literature clearly shows that the Soviet Union has not exceeded 60 Mbps in its current space system. These analyses are necessary but not sufficient to determine mission data rates, and other technologies such as onboard processing and storage could limit the mission data rate well below that which could actually be supported via the communications links. Presently, the Soviet Union appears to be content with data rates in the low-Earth-orbit relay via geostationary mode of 12 Mbps. This limit is a direct result of power amplifier limits, spacecraft antenna size, and the utilization of K{sub u}-band frequencies. 91 refs., 16 figs., 15 tabs.

  11. An evaluation of the utility of anti-granulocyte and anti-leukocyte monoclonal antibodies in the diagnosis of Hodgkin's disease.

    PubMed Central

    Dorfman, R. F.; Gatter, K. C.; Pulford, K. A.; Mason, D. Y.

    1986-01-01

    The immunoreactivity of six different monoclonal antigranulocyte antibodies (Leu M1, TG1, 3C4, BY/87a, BY/37a, and 3CD1) has been evaluated in 23 cases of Hodgkin's disease (7 lymphocyte predominant, 12 nodular sclerosing, and 5 mixed cellularity); in a variety of non-Hodgkin's lymphomas and in a series of reactive and benign lesions of lymph nodes. Applying a monoclonal antibody (PD7/26) to leukocyte common antigen (T200), we have also investigated reports that the L&H variants in nodular lymphocyte predominant Hodgkin's disease are strongly immunoreactive for leukocyte common antigen in contrast to the lack of reactivity of Reed-Sternberg (RS) cells and variants thereof in other forms of Hodgkin's disease. All six monoclonal anti-granulocyte antibodies reacted against RS cells and "Hodgkin's cells" in the nodular sclerosing (NSHD) and mixed cellularity (MCHD) types, with strong cell membrane and juxtanuclear (Golgi) staining. In contrast an anti-leukocyte antibody PD7/26 was unreactive with RS cells and variants thereof in NSHD and MCHD. On the other hand, RS cells and L&H variants thereof in the nodular L&H form of Hodgkin's disease (nodular lymphocyte predominant type) showed reactivity with PD7/26 but not with the anti-granulocyte markers. Rare L&H cells in 2 cases of diffuse lymphocyte predominant type showed reactivity with some, but not all, of the anti-granulocyte antibodies. These findings provide further support for the concept that the nodular L&H type of Hodgkin's disease represents an entity distinct from other forms of this disorder. Our studies also demonstrate the usefulness of these immunoperoxidase techniques when applied to formalinfixed, paraffin-embedded tissues. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5A and B Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 PMID:3717303

  12. Satellite failures revisited

    NASA Astrophysics Data System (ADS)

    Balcerak, Ernie

    2012-12-01

    In January 1994, the two geostationary satellites known as Anik-E1 and Anik-E2, operated by Telesat Canada, failed one after the other within 9 hours, leaving many northern Canadian communities without television and data services. The outage, which shut down much of the country's broadcast television for hours and cost Telesat Canada more than $15 million, generated significant media attention. Lam et al. used publicly available records to revisit the event; they looked at failure details, media coverage, recovery effort, and cost. They also used satellite and ground data to determine the precise causes of those satellite failures. The researchers traced the entire space weather event from conditions on the Sun through the interplanetary medium to the particle environment in geostationary orbit.

  13. Artificial gravity experiment satellites

    NASA Astrophysics Data System (ADS)

    Harada, Tadashi

    1992-07-01

    An overview of the conceptual study of an artificial gravity experiment satellite based on the assumption of a launch by the H-2 launch vehicle with a target launch date in the Year 2000 is presented. While many satellites provided with artificial gravity have been reported in relation to a manned Mars exploration spacecraft mission, the review has been conducted on missions and test subjects only for experimental purposes. Mission requirements were determined based on the results of reviews on the mission, test subjects, and model missions. The system baseline and development plan were based on the results of a study on conceptual structure and scale of the system, including measures to generate artificial gravity. Approximate scale of the system and arm length, mission orbit, visibility of the operation orbit from ground stations in Japan, and satellite attitude on the mission orbit are outlined.

  14. The Clementine satellite

    SciTech Connect

    Not Available

    1994-06-01

    The first US satellite to the Moon in more than two decades was launched from Vandenberg Air Force Base (Santa Barbara County), California, on January 25, 1994. The satellite was named Clementine because it carried only enough fuel to complete its mission before it was [open quotes]lost and gone forever.[close quotes] The Clementine satellite tested 23 advanced technologies during its mission for the Ballistic Missile Defense Organization. In fulfilling its scientific goals, Clementine provided a wealth of information relevant to the mineralogy of the lunar surface. Using six on-board cameras designed and built at the Laboratory, Clementine mapped the entire surface of the Moon at resolutions never before attained. Clementine also provided range data that will be used to construct a relief map of the lunar surface.

  15. Brazilian Small Satellites

    NASA Astrophysics Data System (ADS)

    Carvalho, Himilcon

    Brazilian experience with micro scientific satellites began in 1995 with the SACI project that comprised 2 scientific satellites that carried onboard experiments from Brazil, Japan and US. The first one failed after launch (1998) and the second was lost during the second launch attempt of the Brazilian national launcher, VLS, in1999. Started by 1997, the French-Brazilian Microsatellite Project comprised a set of 9 experiments from French and Brazilian scientists. The project was terminated by the French side in 2002. Currently, there are two ongoing science projects, MIRAX (devoted to X-Ray astronomy) and EQUARS (to study the higher atmosphere). These projects include experiments from US, Netherlands, Japan, Canada, and Brazil, with launch scheduled to 2011 or 2012. This paper presents a brief summary of the history of the development of these satellites along with some highlights on the Brazilian Space Program.

  16. AVS on satellite

    NASA Astrophysics Data System (ADS)

    Zhao, Haiwu; Wang, Guozhong; Hou, Gang

    2005-07-01

    AVS is a new digital audio-video coding standard established by China. AVS will be used in digital TV broadcasting and next general optical disk. AVS adopted many digital audio-video coding techniques developed by Chinese company and universities in recent years, it has very low complexity compared to H.264, and AVS will charge very low royalty fee through one-step license including all AVS tools. So AVS is a good and competitive candidate for Chinese DTV and next generation optical disk. In addition, Chinese government has published a plan for satellite TV signal directly to home(DTH) and a telecommunication satellite named as SINO 2 will be launched in 2006. AVS will be also one of the best hopeful candidates of audio-video coding standard on satellite signal transmission.

  17. ESA's satellite communications programme

    NASA Astrophysics Data System (ADS)

    Bartholome, P.

    1985-02-01

    The developmental history, current status, and future plans of the ESA satellite-communications programs are discussed in a general survey and illustrated with network diagrams and maps. Consideration is given to the parallel development of national and European direct-broadcast systems and telecommunications networks, the position of the European space and electronics industries in the growing world market, the impact of technological improvements (both in satellite systems and in ground-based networks), and the technological and commercial advantages of integrated space-terrestrial networks. The needs for a European definition of the precise national and international roles of satellite communications, for maximum speed in implementing such decisions (before the technology becomes obsolete), and for increased cooperation and standardization to assure European equipment manufacturers a reasonable share of the market are stressed.

  18. Uranus satellites - Surface properties

    NASA Technical Reports Server (NTRS)

    Veverka, J.; Brown, R. H.; Bell, Jeffrey F.

    1991-01-01

    The post-Voyager knowledge of the photometric, colorimetric, spectral, and thermal properties of the Uranian satellites is reviewed, focusing on such fundamental physical properties as albedo, color, and surface texture. While albedo variations of at least a factor of 2 exist, color differences are almost absent (Miranda) or subdued (Oberon). In the case of Titania, the strong opposition effect reported by ground-based observers was confirmed by Voyager. Voyager did not observe the opposition parts of the phase curves of the other satellites. Voyager thermal observations of Ariel and Miranda suggest that both have highly porous regoliths, thermophysically similar to those of Jupiter's icy satellites. At the time of the flyby (south pole facing the sun), maximum surface temperatures reached or exceeded 85 K, but nighttime polar temperatures are predicted to drop to 20 to 30 K because each pole spends about 40 yr in darkness. Ground-based spectroscopy identified water ice as an important surface constituent.

  19. Satellites For Sale

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Dale A. Gardner, having just completed the major portion of his second extravehicular activity (EVA) period in three days, holds up a 'For Sale' sign refering to the two satellites, Palapa B-2 and Westar 6 that they retrieved from orbit after their Payload Assist Modules (PAM) failed to fire. Astronaut Joseph P. Allen IV, who also participated in the two EVAs, is reflected in Gardner's helmet visor. A portion of each of two recovered satellites is in the lower right corner, with Westar 6 nearer Discovery's aft.

  20. Satellite altitude determination uncertainties

    NASA Technical Reports Server (NTRS)

    Siry, J. W.

    1972-01-01

    Satellite altitude determination uncertainties will be discussed from the standpoint of the GEOS-C satellite, from the longer range viewpoint afforded by the Geopause concept. Data are focused on methods for short-arc tracking which are essentially geometric in nature. One uses combinations of lasers and collocated cameras. The other method relies only on lasers, using three or more to obtain the position fix. Two typical locales are looked at, the Caribbean area, and a region associated with tracking sites at Goddard, Bermuda and Canada which encompasses a portion of the Gulf Stream in which meanders develop.

  1. Satellite Laser Ranging operations

    NASA Technical Reports Server (NTRS)

    Pearlman, Michael R.

    1994-01-01

    Satellite Laser Ranging (SLR) is currently providing precision orbit determination for measurements of: 1) Ocean surface topography from satellite borne radar altimetry, 2) Spatial and temporal variations of the gravity field, 3) Earth and ocean tides, 4) Plate tectonic and regional deformation, 5) Post-glacial uplift and subsidence, 6) Variations in the Earth's center-of-mass, and 7) Variations in Earth rotation. SLR also supports specialized programs in time transfer and classical geodetic positioning, and will soon provide precision ranging to support experiments in relativity.

  2. Geodynamics from satellites

    NASA Technical Reports Server (NTRS)

    Kaula, W. M.

    1979-01-01

    The NASA Geodynamics Program is developing a variety of techniques in support of national programs in geodynamics, geomagnetics and earthquake hazard reduction. Global tectonics are to be observed by satellite laser tracking and radio interferometry, which will be used to measure the movements of extended (greater than 200 km) regions to an accuracy of 3 cm, while for shorter distances, lasers enable a more rapid measuring of regional strain accumulation patterns than ground systems. The techniques of Doppler tracking between two satellites to measure the gravity field over the ocean is also under NASA study

  3. Satellite communications system 'Tyulpan'

    NASA Astrophysics Data System (ADS)

    Tchuyan, R. K.; Tarasov, E. V.; Belousov, A. P.; Balyk, V. M.; Kovtunenko, V. M.; Morozov, V. A.; Andreev, V. A.; v'yunenko, K. A.

    1993-10-01

    A concept of the satellite communication system called 'Tyulpan' (because or its tulip-resembling shape) is considered. This conception envisages the use of six satellites-retranslators installed on high-latitude elliptic orbits. Such a system can provide the communication for mean- and high-latitude region of Europe, Asia, and America. For the communication, super small ground stations of 0.4 m in diameter can be used. In the development of system conception, the already existing technical solutions and possibility of conversion or existing installations of military destination were taken into account. Therefore, the system considered can be realized at the earliest possible date.

  4. Declassified intelligence satellite photographs

    USGS Publications Warehouse

    ,

    1998-01-01

    Recently declassified photographs from spy satellites are an important addition to the record of the Earth?s land surface held by the U.S. Geological Survey (USGS). More than 800,000 high-resolution photos taken between 1959 through 1972 were made available by Executive Order of the President. The collection is held at the USGS EROS Data Center, near Sioux Falls, S. Dak., and are offered for public sale. For some purposes in earth science studies, these photos extend the record of changes in the land surface another decade back in time from the advent of the Landsat earth-observing satellite program.

  5. Satellite laser ranging

    NASA Astrophysics Data System (ADS)

    Osorio, J. P.

    1992-03-01

    Laser ranging to satellites is one of the most precise methods for positio ning on the surface of the Earth. Reference is made to the need for precise posi tioning and to the improvement brought by the use of space techniques. Satellite Laser Ranging system is then described and in view of the high precision of the results derived from its measurements comments are made to some of the more important applications: high precision networks tectonic plate motion polar motion and earth''s rotation. Finally plans for system improvement in the near future are also presented.

  6. Benefits Derived From Laser Ranging Measurements for Orbit Determination of the GPS Satellite Orbit

    NASA Technical Reports Server (NTRS)

    Welch, Bryan W.

    2007-01-01

    While navigation systems for the determination of the orbit of the Global Position System (GPS) have proven to be very effective, the current research is examining methods to lower the error in the GPS satellite ephemerides below their current level. Two GPS satellites that are currently in orbit carry retro-reflectors onboard. One notion to reduce the error in the satellite ephemerides is to utilize the retro-reflectors via laser ranging measurements taken from multiple Earth ground stations. Analysis has been performed to determine the level of reduction in the semi-major axis covariance of the GPS satellites, when laser ranging measurements are supplemented to the radiometric station keeping, which the satellites undergo. Six ground tracking systems are studied to estimate the performance of the satellite. The first system is the baseline current system approach which provides pseudo-range and integrated Doppler measurements from six ground stations. The remaining five ground tracking systems utilize all measurements from the current system and laser ranging measurements from the additional ground stations utilized within those systems. Station locations for the additional ground sites were taken from a listing of laser ranging ground stations from the International Laser Ranging Service. Results show reductions in state covariance estimates when utilizing laser ranging measurements to solve for the satellite s position component of the state vector. Results also show dependency on the number of ground stations providing laser ranging measurements, orientation of the satellite to the ground stations, and the initial covariance of the satellite's state vector.

  7. Disparate Rates of Utilization and Progression to Combined Heart Failure and Chronic Obstructive Pulmonary Disease among Asians and Pacific Islanders in Hawai'i.

    PubMed

    Davis, James; Tam, Elizabeth; Taira, Deborah

    2016-08-01

    The objectives of the study were to compare ethnic differences in the rates of emergency department (ED) visits and hospitalizations, and to examine ethnic differences in how quickly patients with either chronic obstructive pulmonary disease (COPD) or congestive heart failure (CHF) developed both diseases. A large health plan in Hawai.i provided administrative data (2007 to 2010) on patients of Native Hawaiian, Japanese, Chinese, Filipino, and White race/ethnicity. The study found distinct patterns of health risks among the multi-ethnic population of patients with COPD, CHF, or both conditions. Native Hawaiians had the highest rates of ED visits and hospitalizations. Japanese, the largest ethnic group and relatively low health risks, were selected as the reference population. In adjusted regression models, Filipino patients with CHF developed COPD the most rapidly; 71% faster than Japanese patients. Compared to Japanese, Native Hawaiians with COPD transitioned to CHF 68% faster. The study highlights ethnic disparities in adverse events and disease progression in patients with COPD and CHF, with important implications for clinical practice. Health care providers may want to inform patients of ways to mitigate the risks. PMID:27563499

  8. Disparate Rates of Utilization and Progression to Combined Heart Failure and Chronic Obstructive Pulmonary Disease among Asians and Pacific Islanders in Hawai‘i

    PubMed Central

    Tam, Elizabeth; Taira, Deborah

    2016-01-01

    The objectives of the study were to compare ethnic differences in the rates of emergency department (ED) visits and hospitalizations, and to examine ethnic differences in how quickly patients with either chronic obstructive pulmonary disease (COPD) or congestive heart failure (CHF) developed both diseases. A large health plan in Hawai.i provided administrative data (2007 to 2010) on patients of Native Hawaiian, Japanese, Chinese, Filipino, and White race/ethnicity. The study found distinct patterns of health risks among the multi-ethnic population of patients with COPD, CHF, or both conditions. Native Hawaiians had the highest rates of ED visits and hospitalizations. Japanese, the largest ethnic group and relatively low health risks, were selected as the reference population. In adjusted regression models, Filipino patients with CHF developed COPD the most rapidly; 71% faster than Japanese patients. Compared to Japanese, Native Hawaiians with COPD transitioned to CHF 68% faster. The study highlights ethnic disparities in adverse events and disease progression in patients with COPD and CHF, with important implications for clinical practice. Health care providers may want to inform patients of ways to mitigate the risks. PMID:27563499

  9. Utility of recombinant integrin alpha v beta6 as a capture reagent in immunoassays for the diagnosis of foot-and-mouth disease.

    PubMed

    Ferris, Nigel P; Abrescia, Nicola G A; Stuart, David I; Jackson, Terry; Burman, Alison; King, Donald P; Paton, David J

    2005-07-01

    Recombinant integrin alpha v beta6 was evaluated as a capture ligand in a sandwich ELISA for the detection and serotyping of foot-and-mouth disease (FMD) virus. Our routinely applied method employs seven serotype-specific rabbit polyclonal antibodies as capture ligands and seven serotype-specific guinea pig polyclonal antibodies as detecting reagents. The recombinant integrin bound FMD virus of all seven serotypes but not that of another vesicular disease, swine vesicular disease (SVD). Considerable heterotypic cross-reactions were evident when using the integrin capture ligand in combination with guinea pig detecting antibodies but totally type-specific reactions resulted when serotype-specific monoclonal antibodies (mabs) were used instead of the guinea pig reagents. The specificity of reaction of the integrin capture/mab detector combination was superior to that of our routinely employed rabbit/guinea pig ELISA and offers an improvement for test interpretation. As a universal trapping reagent for all FMD virus serotypes the alpha v beta6 recombinant protein also has the potential for application in other test procedures for viral identification (e.g. pen-side chromatographic strip-tests, biosensors, immunocapture RT-PCR, antigenic characterization procedures and monoclonal antibody profiling of emerging field virus strains) and in antibody detection assays employed for the diagnosis of FMD. PMID:15893568

  10. The American Satellite Company (ASC) satellite deployed from payload bay

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The American Satellite Company (ASC) communications satellite is deployed from the payload bay of the Shuttle Discovery. A portion of the cloudy surface of the earth can be seen to the left of the frame.

  11. Bird migration and avian influenza: a comparison of hydrogen stable isotopes and satellite tracking methods

    USGS Publications Warehouse

    Bridge, Eli S.; Kelly, Jeffrey F.; Xiao, Xiangming; Takekawa, John Y.; Hill, Nichola J.; Yamage, Mat; Haque, Enam Ul; Islam, Mohammad Anwarul; Mundkur, Taej; Yavuz, Kiraz Erciyas; Leader, Paul; Leung, Connie Y.H.; Smith, Bena; Spragens, Kyle A.; Vandegrift, Kurt J.; Hosseini, Parviez R.; Saif, Samia; Mohsanin, Samiul; Mikolon, Andrea; Islam, Ausrafal; George, Acty; Sivananinthaperumal, Balachandran; Daszak, Peter; Newman, Scott H.

    2014-01-01

    Satellite-based tracking of migratory waterfowl is an important tool for understanding the potential role of wild birds in the long-distance transmission of highly pathogenic avian influenza. However, employing this technique on a continental scale is prohibitively expensive. This study explores the utility of stable isotope ratios in feathers in examining both the distances traveled by migratory birds and variation in migration behavior. We compared the satellite-derived movement data of 22 ducks from 8 species captured at wintering areas in Bangladesh, Turkey, and Hong Kong with deuterium ratios (δD) in the feathers of these and other individuals captured at the same locations. We derived likely molting locations from the satellite tracking data and generated expected isotope ratios based on an interpolated map of δD in rainwater. Although δD was correlated with the distance between wintering and molting locations, surprisingly, measured δD values were not correlated with either expected values or latitudes of molting sites. However, population-level parameters derived from the satellite-tracking data, such as mean distance between wintering and molting locations and variation in migration distance, were reflected by means and variation of the stable isotope values. Our findings call into question the relevance of the rainfall isotope map for Asia for linking feather isotopes to molting locations, and underscore the need for extensive ground truthing in the form of feather-based isoscapes. Nevertheless, stable isotopes from feathers could inform disease models by characterizing the degree to which regional breeding populations interact at common wintering locations. Feather isotopes also could aid in surveying wintering locations to determine where high-resolution tracking techniques (e.g. satellite tracking) could most effectively be employed. Moreover, intrinsic markers such as stable isotopes offer the only means of inferring movement information from

  12. Bird Migration and Avian Influenza: A Comparison of Hydrogen Stable Isotopes and Satellite Tracking Methods.

    PubMed

    Bridge, Eli S; Kelly, Jeffrey F; Xiao, Xiangming; Takekawa, John Y; Hill, Nichola J; Yamage, Mat; Haque, Enam Ul; Islam, Mohammad Anwarul; Mundkur, Taej; Yavuz, Kiraz Erciyas; Leader, Paul; Leung, Connie Y H; Smith, Bena; Spragens, Kyle A; Vandegrift, Kurt; Hosseini, Parviez R; Saif, Samia; Mohsanin, Samiul; Mikolon, Andrea; Islam, Ausrafal; George, Acty; Sivananinthaperumal, Balachandran; Daszak, Peter; Newman, Scott H

    2014-10-01

    Satellite-based tracking of migratory waterfowl is an important tool for understanding the potential role of wild birds in the long-distance transmission of highly pathogenic avian influenza. However, employing this technique on a continental scale is prohibitively expensive. This study explores the utility of stable isotope ratios in feathers in examining both the distances traveled by migratory birds and variation in migration behavior. We compared the satellite-derived movement data of 22 ducks from 8 species captured at wintering areas in Bangladesh, Turkey, and Hong Kong with deuterium ratios (δD) of these and other individuals captured at the same locations. We derived likely molting locations from the satellite tracking data and generated expected isotope ratios based on an interpolated map of δD in rainwater. Although δD was correlated with the distance between wintering and molting locations, surprisingly, measured δD values were not correlated with either expected values or latitudes of molting sites. However, population-level parameters derived from the satellite-tracking data, such as mean distance between wintering and molting locations and variation in migration distance, were reflected by means and variation of the stable isotope values. Our findings call into question the relevance of the rainfall isotope map for Asia for linking feather isotopes to molting locations, and underscore the need for extensive ground truthing in the form of feather-based isoscapes. Nevertheless, stable isotopes from feathers could inform disease models by characterizing the degree to which regional breeding populations interact at common wintering locations. Feather isotopes also could aid in surveying wintering locations to determine where high-resolution tracking techniques (e.g. satellite tracking) could most effectively be employed. Moreover, intrinsic markers such as stable isotopes offer the only means of inferring movement information from birds that have died

  13. Bird Migration and Avian Influenza: A Comparison of Hydrogen Stable Isotopes and Satellite Tracking Methods.

    PubMed

    Bridge, Eli S; Kelly, Jeffrey F; Xiao, Xiangming; Takekawa, John Y; Hill, Nichola J; Yamage, Mat; Haque, Enam Ul; Islam, Mohammad Anwarul; Mundkur, Taej; Yavuz, Kiraz Erciyas; Leader, Paul; Leung, Connie Y H; Smith, Bena; Spragens, Kyle A; Vandegrift, Kurt; Hosseini, Parviez R; Saif, Samia; Mohsanin, Samiul; Mikolon, Andrea; Islam, Ausrafal; George, Acty; Sivananinthaperumal, Balachandran; Daszak, Peter; Newman, Scott H

    2014-10-01

    Satellite-based tracking of migratory waterfowl is an important tool for understanding the potential role of wild birds in the long-distance transmission of highly pathogenic avian influenza. However, employing this technique on a continental scale is prohibitively expensive. This study explores the utility of stable isotope ratios in feathers in examining both the distances traveled by migratory birds and variation in migration behavior. We compared the satellite-derived movement data of 22 ducks from 8 species captured at wintering areas in Bangladesh, Turkey, and Hong Kong with deuterium ratios (δD) of these and other individuals captured at the same locations. We derived likely molting locations from the satellite tracking data and generated expected isotope ratios based on an interpolated map of δD in rainwater. Although δD was correlated with the distance between wintering and molting locations, surprisingly, measured δD values were not correlated with either expected values or latitudes of molting sites. However, population-level parameters derived from the satellite-tracking data, such as mean distance between wintering and molting locations and variation in migration distance, were reflected by means and variation of the stable isotope values. Our findings call into question the relevance of the rainfall isotope map for Asia for linking feather isotopes to molting locations, and underscore the need for extensive ground truthing in the form of feather-based isoscapes. Nevertheless, stable isotopes from feathers could inform disease models by characterizing the degree to which regional breeding populations interact at common wintering locations. Feather isotopes also could aid in surveying wintering locations to determine where high-resolution tracking techniques (e.g. satellite tracking) could most effectively be employed. Moreover, intrinsic markers such as stable isotopes offer the only means of inferring movement information from birds that have died

  14. Bird Migration and Avian Influenza: A Comparison of Hydrogen Stable Isotopes and Satellite Tracking Methods

    PubMed Central

    Kelly, Jeffrey F.; Xiao, Xiangming; Takekawa, John Y.; Hill, Nichola J.; Yamage, Mat; Haque, Enam Ul; Islam, Mohammad Anwarul; Mundkur, Taej; Yavuz, Kiraz Erciyas; Leader, Paul; Leung, Connie Y. H.; Smith, Bena; Spragens, Kyle A.; Vandegrift, Kurt; Hosseini, Parviez R.; Saif, Samia; Mohsanin, Samiul; Mikolon, Andrea; Islam, Ausrafal; George, Acty; Sivananinthaperumal, Balachandran; Daszak, Peter; Newman, Scott H.

    2014-01-01

    Satellite-based tracking of migratory waterfowl is an important tool for understanding the potential role of wild birds in the long-distance transmission of highly pathogenic avian influenza. However, employing this technique on a continental scale is prohibitively expensive. This study explores the utility of stable isotope ratios in feathers in examining both the distances traveled by migratory birds and variation in migration behavior. We compared the satellite-derived movement data of 22 ducks from 8 species captured at wintering areas in Bangladesh, Turkey, and Hong Kong with deuterium ratios (δD) of these and other individuals captured at the same locations. We derived likely molting locations from the satellite tracking data and generated expected isotope ratios based on an interpolated map of δD in rainwater. Although δD was correlated with the distance between wintering and molting locations, surprisingly, measured δD values were not correlated with either expected values or latitudes of molting sites. However, population-level parameters derived from the satellite-tracking data, such as mean distance between wintering and molting locations and variation in migration distance, were reflected by means and variation of the stable isotope values. Our findings call into question the relevance of the rainfall isotope map for Asia for linking feather isotopes to molting locations, and underscore the need for extensive ground truthing in the form of feather-based isoscapes. Nevertheless, stable isotopes from feathers could inform disease models by characterizing the degree to which regional breeding populations interact at common wintering locations. Feather isotopes also could aid in surveying wintering locations to determine where high-resolution tracking techniques (e.g. satellite tracking) could most effectively be employed. Moreover, intrinsic markers such as stable isotopes offer the only means of inferring movement information from birds that have died

  15. [Use of satellites for public health purposes in tropical areas].

    PubMed

    Meynard, J B; Orlandi, E; Rogier, C; Sbai Idrissi, K; Deparis, X; Peyreffite, C; Lightburn, E; Malosse, D; Migliani, R; Spiegel, A; Boutin, J P

    2003-01-01

    The epidemiological hallmark of the new millennium has been the emergence or recrudescence of transmissible diseases with high epidemic potential. Disease tracking is becoming an increasingly global task requiring implementation of more and more sophisticated control strategies and facilities for sustainable development. A promising initiative involves the use of satellite technology to monitor and forecast the spread of disease. The Health Early Warning System (HEWS) was designed based on successful application of satellite data in food programs as well as in other areas (e.g. weather, farming and fishing). The HEWS integrates data from communications, remote-sensing and positioning satellites. The purpose of this review is to present the main studies containing satellite data on public health in tropical areas. Satellite data has allowed development of more reactive epidemiological tracking networks better suited to increasing population mobility, correlation of environmental factors (vegetation index, rainfall and ocean surface color) with human, animal and insect factors in epidemiological studies and assessment of the role of such factors in the development or reappearance of disease. Satellite technology holds great promise for more efficient management of public health problems in tropical areas. PMID:12891742

  16. [Use of satellites for public health purposes in tropical areas].

    PubMed

    Meynard, J B; Orlandi, E; Rogier, C; Sbai Idrissi, K; Deparis, X; Peyreffite, C; Lightburn, E; Malosse, D; Migliani, R; Spiegel, A; Boutin, J P

    2003-01-01

    The epidemiological hallmark of the new millennium has been the emergence or recrudescence of transmissible diseases with high epidemic potential. Disease tracking is becoming an increasingly global task requiring implementation of more and more sophisticated control strategies and facilities for sustainable development. A promising initiative involves the use of satellite technology to monitor and forecast the spread of disease. The Health Early Warning System (HEWS) was designed based on successful application of satellite data in food programs as well as in other areas (e.g. weather, farming and fishing). The HEWS integrates data from communications, remote-sensing and positioning satellites. The purpose of this review is to present the main studies containing satellite data on public health in tropical areas. Satellite data has allowed development of more reactive epidemiological tracking networks better suited to increasing population mobility, correlation of environmental factors (vegetation index, rainfall and ocean surface color) with human, animal and insect factors in epidemiological studies and assessment of the role of such factors in the development or reappearance of disease. Satellite technology holds great promise for more efficient management of public health problems in tropical areas.

  17. Satellite orbit determination and gravity field recovery from satellite-to-satellite tracking

    NASA Astrophysics Data System (ADS)

    Wakker, K. F.; Ambrosius, B. A. C.; Leenman, H.

    1989-07-01

    Studies on satellite-to-satellite tracking (SST) with POPSAT (a geodetic satellite concept) and a ERS-class (Earth observation) satellite, a Satellite-to-Satellite Tracking (SST) gravity mission, and precise gravity field determination methods and mission requirements are reported. The first two studies primarily address the application of SST between the high altitude POPSAT and an ERS-class or GRM (Geopotential Research Mission) satellite to the orbit determination of the latter two satellites. Activities focussed on the determination of the tracking coverage of the lower altitude satellite by ground based tracking systems and by POPSAT, orbit determination error analysis and the determination of the surface forces acting on GRM. The third study surveys principles of SST, uncertainties of existing drag models, effects of direct luni-solar attraction and tides on orbit and the gravity gradient observable. Detailed ARISTOTELES (which replaced POPSAT) orbit determination error analyses were performed for various ground based tracking networks.

  18. A Canadian small satellite launch vehicle

    NASA Astrophysics Data System (ADS)

    Payne, B.; Reinhardt, A.; Oconnor, D.; Wehrle, V.

    1993-11-01

    Today's small satellites can accomplish missions of sophistication and utility which would have required large satellites several years ago. A remaining constraint to further growth of the small satellite business is the lack of appropriately priced launch vehicles. Based on its experience with designing the Black Brant series of suborbital launchers, Bristol Aerospace is developing a family of orbital launch vehicles aimed specifically at the small-satellite market. The new Black Brant 2000 series will be based on three vehicles: the core vehicle (300) uses four solid propellant motors, with the first and fourth stages using existing flight-proven motors and the second and third to use a common, new motor specifically developed for this application. The upgraded 400 and 500 vehicles are derived by adding strap-ons to the 300 to raise the 600-km payload capability to 294 kg. A description of the vehicle hardware and system performance of the Black Brant 2000 series is presented, including motors, interstages, guidance system, avionics, payload fairing, and interfaces. It is believed that the series can be flight qualified by 1997.

  19. Using Satellite Data in Weather Forecasting: I

    NASA Technical Reports Server (NTRS)

    Jedlovec, Gary J.; Suggs, Ronnie J.; Lecue, Juan M.

    2006-01-01

    The GOES Product Generation System (GPGS) is a set of computer codes and scripts that enable the assimilation of real-time Geostationary Operational Environmental Satellite (GOES) data into regional-weather-forecasting mathematical models. The GPGS can be used to derive such geophysical parameters as land surface temperature, the amount of precipitable water, the degree of cloud cover, the surface albedo, and the amount of insolation from satellite measurements of radiant energy emitted by the Earth and its atmosphere. GPGS incorporates a priori information (initial guesses of thermodynamic parameters of the atmosphere) and radiometric measurements from the geostationary operational environmental satellites along with mathematical models of physical principles that govern the transfer of energy in the atmosphere. GPGS solves the radiative-transfer equation and provides the resulting data products in formats suitable for use by weather-forecasting computer programs. The data-assimilation capability afforded by GPGS offers the potential to improve local weather forecasts ranging from 3 hours to 2 days - especially with respect to temperature, humidity, cloud cover, and the probability of precipitation. The improvements afforded by GPGS could be of interest to news media, utility companies, and other organizations that utilize regional weather forecasts.

  20. Experimental Satellite Quantum Communications.

    PubMed

    Vallone, Giuseppe; Bacco, Davide; Dequal, Daniele; Gaiarin, Simone; Luceri, Vincenza; Bianco, Giuseppe; Villoresi, Paolo

    2015-07-24

    Quantum communication (QC), namely, the faithful transmission of generic quantum states, is a key ingredient of quantum information science. Here we demonstrate QC with polarization encoding from space to ground by exploiting satellite corner cube retroreflectors as quantum transmitters in orbit and the Matera Laser Ranging Observatory of the Italian Space Agency in Matera, Italy, as a quantum receiver. The quantum bit error ratio (QBER) has been kept steadily low to a level suitable for several quantum information protocols, as the violation of Bell inequalities or quantum key distribution (QKD). Indeed, by taking data from different satellites, we demonstrate an average value of QBER=4.6% for a total link duration of 85 s. The mean photon number per pulse μ_{sat} leaving the satellites was estimated to be of the order of one. In addition, we propose a fully operational satellite QKD system by exploiting our communication scheme with orbiting retroreflectors equipped with a modulator, a very compact payload. Our scheme paves the way toward the implementation of a QC worldwide network leveraging existing receivers. PMID:26252672

  1. Solar wind monitor satellite

    SciTech Connect

    Kappenman, J.G. ); Albertson, V.D. ); Damsk, B.L. ); Dale, S.J. )

    1990-05-01

    This authors discuss the effects of geomagnetic disturbances on power systems. They also discuss the effects of geomagnetic storms on spacecraft electronics, pipelines, and geophysical surveys for oil and minerals. The current satellite system technology used in geomagnetic disturbance forecasts is described and assessed.

  2. Small satellite radiometric measurements

    SciTech Connect

    Weber, P.G.

    1991-01-01

    A critical need for the Mission to Planet Earth is to provide continuous, well-calibrated radiometric data for the radiation budget. This paper describes a new, compact, flexible radiometer which will provide both spectrally integrated data and data in selected spectral bands. The radiometer design is suitable for use on small satellites, aircraft, or remotely piloted vehicles (RPVs). 12 refs., 2 figs.

  3. Creating Better Satellite Conferences.

    ERIC Educational Resources Information Center

    Horner, Tommy

    1998-01-01

    Presents four ways to improve broadcasts of company satellite conferences, including creative site selection (using facilities at educational institutions rather than hotel rooms); creative programming (using graphics and other interruptions to break up lectures or speeches); creative crew selection; and creative downlink site activities (to…

  4. Domestic Communications Satellites.

    ERIC Educational Resources Information Center

    Network Project Notebook, 1972

    1972-01-01

    The June, 1972 Federal Communications Commission's (FCC) decision allowed an "open skies" policy in regard to domestic communication satellites and raised Liberal opposition to a situation where exclusive and unchecked communications power is now in the hands of private entrepreneurs, primarily the big Defense Department oriented aerospace…

  5. Satellite Town Meeting.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    On the third Tuesday of each month, U.S. Secretary of Education, Richard W. Riley, and Deputy Secretary, Madeleine M. Kunin, host the Satellite Town Meeting--a live, interactive teleconference where renowned national experts, local educators, and community leaders share ideas on how to improve schools and reach the National Educational Goals. It…

  6. THE ONE ROOM SATELLITE.

    ERIC Educational Resources Information Center

    DREYFUS, LEE S.

    A WISCONSIN HIGH SCHOOL FRENCH CLASS AND A GROUP OF STUDENTS IN AN ENGLISH CALSS AT THE LYCEE HENRI IV OF PARIS, FRANCE, PARTICIPATED IN A COMBINED CLASS SESSION IN THE FIRST INTERNATIONAL TV CLASSROOM EXCHANGE. THE TV SIGNALS WERE EXCHANGED BY MEANS OF THE EARLY BIRD SATELLITE AND PERMITTED THE STUDENTS TO EXCHANGE MESSAGES. DURING THE TELECAST…

  7. Data distribution satellite

    NASA Technical Reports Server (NTRS)

    Price, Kent M.; Jorasch, Ronald E.; Wiskerchen, Michael J.

    1991-01-01

    A description is given of a data distribution satellite (DDS) system. The DDS would operate in conjunction with the tracking and data relay satellite system to give ground-based users real time, two-way access to instruments in space and space-gathered data. The scope of work includes the following: (1) user requirements are derived; (2) communication scenarios are synthesized; (3) system design constraints and projected technology availability are identified; (4) DDS communications payload configuration is derived, and the satellite is designed; (5) requirements for earth terminals and network control are given; (6) system costs are estimated, both life cycle costs and user fees; and (7) technology developments are recommended, and a technology development plan is given. The most important results obtained are as follows: (1) a satellite designed for launch in 2007 is feasible and has 10 Gb/s capacity, 5.5 kW power, and 2000 kg mass; (2) DDS features include on-board baseband switching, use of Ku- and Ka-bands, multiple optical intersatellite links; and (3) system user costs are competitive with projected terrestrial communication costs.

  8. Satellite camera image navigation

    NASA Technical Reports Server (NTRS)

    Kamel, Ahmed A. (Inventor); Graul, Donald W. (Inventor); Savides, John (Inventor); Hanson, Charles W. (Inventor)

    1987-01-01

    Pixels within a satellite camera (1, 2) image are precisely located in terms of latitude and longitude on a celestial body, such as the earth, being imaged. A computer (60) on the earth generates models (40, 50) of the satellite's orbit and attitude, respectively. The orbit model (40) is generated from measurements of stars and landmarks taken by the camera (1, 2), and by range data. The orbit model (40) is an expression of the satellite's latitude and longitude at the subsatellite point, and of the altitude of the satellite, as a function of time, using as coefficients (K) the six Keplerian elements at epoch. The attitude model (50) is based upon star measurements taken by each camera (1, 2). The attitude model (50) is a set of expressions for the deviations in a set of mutually orthogonal reference optical axes (x, y, z) as a function of time, for each camera (1, 2). Measured data is fit into the models (40, 50) using a walking least squares fit algorithm. A transformation computer (66 ) transforms pixel coordinates as telemetered by the camera (1, 2) into earth latitude and longitude coordinates, using the orbit and attitude models (40, 50).

  9. Satellite Weather Watch.

    ERIC Educational Resources Information Center

    Summers, R. Joe

    1982-01-01

    Describes an inexpensive (about $1,500) direct-readout ground station for use in secondary school science/mathematics programs. Includes suggested activities including, among others, developing map overlays, operating station equipment, interpreting satellite data, developing weather forecasts, and using microcomputers for data storage, orbit…

  10. On satellite constellation selection

    SciTech Connect

    Canavan, G.H.

    1991-05-01

    Analytical estimates can be used to produce and discuss optimal constellations. They are in close agreement with phase-space estimates and exact solutions. They suggest that distributions of inclined orbits could reduce satellite numbers by factors of 2--3 while improving uniformity. 4 refs., 2 figs.

  11. Retroreflector spherical satellite

    NASA Astrophysics Data System (ADS)

    Akentyev, A. S.; Vasiliev, V. P.; Sadovnikov, M. A.; Sokolov, A. L.; Shargorodskiy, V. D.

    2015-10-01

    Specific features of spherical retroreflector arrays for high-precision laser ranging are considered, and errors in distance measurements are analyzed. A version of a glass retroreflector satellite with a submillimeter "target error" is proposed. Its corner cube reflectors are located in depressions to reduce the working angular aperture, and their faces have a dielectric interference coating.

  12. Experimental Satellite Quantum Communications

    NASA Astrophysics Data System (ADS)

    Vallone, Giuseppe; Bacco, Davide; Dequal, Daniele; Gaiarin, Simone; Luceri, Vincenza; Bianco, Giuseppe; Villoresi, Paolo

    2015-07-01

    Quantum communication (QC), namely, the faithful transmission of generic quantum states, is a key ingredient of quantum information science. Here we demonstrate QC with polarization encoding from space to ground by exploiting satellite corner cube retroreflectors as quantum transmitters in orbit and the Matera Laser Ranging Observatory of the Italian Space Agency in Matera, Italy, as a quantum receiver. The quantum bit error ratio (QBER) has been kept steadily low to a level suitable for several quantum information protocols, as the violation of Bell inequalities or quantum key distribution (QKD). Indeed, by taking data from different satellites, we demonstrate an average value of QBER =4.6 % for a total link duration of 85 s. The mean photon number per pulse μsat leaving the satellites was estimated to be of the order of one. In addition, we propose a fully operational satellite QKD system by exploiting our communication scheme with orbiting retroreflectors equipped with a modulator, a very compact payload. Our scheme paves the way toward the implementation of a QC worldwide network leveraging existing receivers.

  13. Experimental Satellite Quantum Communications.

    PubMed

    Vallone, Giuseppe; Bacco, Davide; Dequal, Daniele; Gaiarin, Simone; Luceri, Vincenza; Bianco, Giuseppe; Villoresi, Paolo

    2015-07-24

    Quantum communication (QC), namely, the faithful transmission of generic quantum states, is a key ingredient of quantum information science. Here we demonstrate QC with polarization encoding from space to ground by exploiting satellite corner cube retroreflectors as quantum transmitters in orbit and the Matera Laser Ranging Observatory of the Italian Space Agency in Matera, Italy, as a quantum receiver. The quantum bit error ratio (QBER) has been kept steadily low to a level suitable for several quantum information protocols, as the violation of Bell inequalities or quantum key distribution (QKD). Indeed, by taking data from different satellites, we demonstrate an average value of QBER=4.6% for a total link duration of 85 s. The mean photon number per pulse μ_{sat} leaving the satellites was estimated to be of the order of one. In addition, we propose a fully operational satellite QKD system by exploiting our communication scheme with orbiting retroreflectors equipped with a modulator, a very compact payload. Our scheme paves the way toward the implementation of a QC worldwide network leveraging existing receivers.

  14. Small satellite space operations

    NASA Technical Reports Server (NTRS)

    Reiss, Keith

    1994-01-01

    CTA Space Systems has played a premier role in the development of the 'lightsat' programs of the 80's and 90's. The high costs and development times associated with conventional LEO satellite design, fabrication, launch, and operations continue to motivate the development of new methodologies, techniques, and generally low cost and less stringently regulated satellites. These spacecraft employ low power 'lightsat' communications (versus TDRSS for NASA's LEO's) and typically fly missions with payload/experiment suites that can succeed, for example, without heavily redundant backup systems and large infrastructures of personnel and ground support systems. Such small yet adaptable satellites are also typified by their very short contract-to-launch times (often one to two years). This paper reflects several of the methodologies and perspectives of our successful involvement in these innovative programs and suggests how they might relieve NASA's mounting pressures to reduce the cost of both the spacecraft and their companion mission operations. It focuses on the use of adaptable, sufficiently powerful yet inexpensive PC-based ground systems for wide ranging user terminal (UT) applications and master control facilities for mission operations. These systems proved themselves in successfully controlling more than two dozen USAF, USN, and ARPA satellites at CTA/SS. UT versions have linked with both GEO and LEO satellites and functioned autonomously in relay roles often in remote parts of the world. LEO applications particularly illustrate the efficacy of these concepts since a user can easily mount a lightweight antenna, usually an omni or helix with light duty rotors and PC-based drivers. A few feet of coax connected to a small transceiver module (the size of a small PC) and a serial line to an associated PC establishes a communications link and together with the PC constitute a viable ground station. Applications included geomagnetic mapping; spaceborne solid state

  15. Cibola flight experiment satellite

    NASA Astrophysics Data System (ADS)

    Davies, P.; Liddle, Doug; Paffett, John; Sweeting, Martin; Curiel, A.; Sun, Wei; Eves, Stuart

    2004-11-01

    In order to achieve an "economy of scale" with respect to payload capacity the major trend in telecommunications satellites is for larger and larger platforms. With these large platforms the level of integration between platform and payload is increasing leading to longer delivery schedules. The typical lifecycle for procurement of these large telecommunications satellites is now 3-6 years depending on the level of non-recurring engineering needed. Surrey Satellite Technology Ltd (SSTL) has designed a low-cost platform aimed at telecommunications and navigation applications. SSTL's Geostationary Minisatellite Platform (GMP) is a new entrant addressing the lower end of the market with payloads up to 250kg requiring less than 1.5 kW power. The British National Space Centre through the MOSAIC Small Satellite Initiative supported the development of GMP. The main design goals for GMP are low-cost for the complete mission including launch and operations and a platform allowing flexible payload accommodation. GMP is specifically designed to allow rapid development and deployment with schedules typically between 1 and 2 years from contract signature to flight readiness. GMP achieves these aims by a modular design where the level of integration between the platform and payload is low. The modular design decomposes the satellite into three major components - the propulsion bay, the avionics bay and the payload module. Both the propulsion and avionics bays are reusable, largely unchanged, and independent of the payload configuration. Such a design means that SSTL or a 3rd party manufacturer can manufacture the payload in parallel to the platform with integration taking place quite late in the schedule. In July 2003 SSTL signed a contract for ESA's first Galileo navigation satellite known as GSTBV2/A. The satellite is based on GMP and ESA plan to launch it into a MEO orbit late in 2005. The second flight of GMP is likely to be in 2006 carrying a geostationary payload

  16. The clinical utility of anti-chromatin antibodies as measured by BioPlex 2200 in the diagnosis of systemic lupus erythematosus versus other rheumatic diseases

    PubMed Central

    Bose, Nilanjana; Wang, Xiaofeng; Gupta, Majula; Yao, Qingping

    2012-01-01

    Background The detection of autoantibodies is indispensable to systemic lupus erythematosus (SLE). Bioplex 2200 ANA screen is a multiplex immunoassay system that allows simultaneous determination of autoantibodies to extractable nuclear antigens (ENA) including anti-chromatin antibodies (ACAs). However, the clinical significance of the ACAs by this new method in SLE patients has not been studied in comparison with other rheumatic disorders. We performed a retrospective study of patients with rheumatic diseases to assess the diagnostic value of the ACAs by Bioplex 2200 method in SLE. Methods Adult patients with rheumatic complaints seen by rheumatologists at the Cleveland Clinic between January 2008 and February 2010 were screened for positive anti-ENA antibodies by the Bioplex 2200. Patients with positive anti-ENA antibodies were classified into two populations based upon the presence and absence of the ACAs. We retrospectively studied the clinical and laboratory data of these patients. Results A total of 764 subjects with positive anti-ENA antibodies were screened, including 115 with positive ACAs. There were 93 SLE patients consisting of 58 with positive ACAs and 35 with negative ACAs. The sensitivity, specificity, positive predictive value and negative predictive value of the ACAs in SLE were 62.4%, 91.5%, 50.4% and 94.6% respectively. Apart from SLE, positive ACAs were associated with mixed connective tissue disease (MCTD)/undifferentiated CTD (UCTD) and other autoimmune diseases. No correlation was found between the ACAs and lupus glomerulonephritis or anti-dsDNA antibodies. Conclusions Measurement of the ACAs by the Bioplex 2200 is specific for diagnosing SLE but not useful for differentiating between SLE and MCTD/UCTD. PMID:22993651

  17. Utilization and Safety of Common Over-the-Counter Dietary/Nutritional Supplements, Herbal Agents, and Homeopathic Compounds for Disease Prevention.

    PubMed

    Trivedi, Ruchir; Salvo, Marissa C

    2016-09-01

    Dietary supplements are commonly used by patients as part of their medical care plan. Often clinicians may not be aware of their use, because patients do not always consider these to be medications. All clinicians need to continually ask patients about their use of dietary supplements when collecting a medication history. Dietary supplements and prescription medications often share similar enzymatic pathways for their metabolism. These interactions may lead to severe adverse reactions. This article reviews available evidence for a variety of dietary supplements in select disease categories.

  18. Utilization and Safety of Common Over-the-Counter Dietary/Nutritional Supplements, Herbal Agents, and Homeopathic Compounds for Disease Prevention.

    PubMed

    Trivedi, Ruchir; Salvo, Marissa C

    2016-09-01

    Dietary supplements are commonly used by patients as part of their medical care plan. Often clinicians may not be aware of their use, because patients do not always consider these to be medications. All clinicians need to continually ask patients about their use of dietary supplements when collecting a medication history. Dietary supplements and prescription medications often share similar enzymatic pathways for their metabolism. These interactions may lead to severe adverse reactions. This article reviews available evidence for a variety of dietary supplements in select disease categories. PMID:27542428

  19. Aqua satellite orbiting the Earth

    NASA Video Gallery

    This animation shows the Aqua satellite orbiting the Earth on August 27, 2005 by revealing MODIS true-color imagery for that day. This animation is on a cartesian map projection, so the satellite w...

  20. Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

    PubMed Central

    Patani, Rickie; Lewis, Patrick A; Trabzuni, Daniah; Puddifoot, Clare A; Wyllie, David J A; Walker, Robert; Smith, Colin; Hardingham, Giles E; Weale, Michael; Hardy, John; Chandran, Siddharthan; Ryten, Mina

    2012-01-01

    A major goal in regenerative medicine is the predictable manipulation of human embryonic stem cells (hESCs) to defined cell fates that faithfully represent their somatic counterparts. Directed differentiation of hESCs into neuronal populations has galvanized much interest into their potential application in modelling neurodegenerative disease. However, neurodegenerative diseases are age-related, and therefore establishing the maturational comparability of hESC-derived neural derivatives is critical to generating accurate in vitro model systems. We address this issue by comparing genome-wide, exon-specific expression analyses of pluripotent hESCs, multipotent neural precursor cells and a terminally differentiated enriched neuronal population to expression data from post-mortem foetal and adult human brain samples. We show that hESC-derived neuronal cultures (using a midbrain differentiation protocol as a prototypic example of lineage restriction), while successful in generating physiologically functional neurons, are closer to foetal than adult human brain in terms of molecular maturation. These findings suggest that developmental stage has a more dominant influence on the cellular transcriptome than regional identity. In addition, we demonstrate that developmentally regulated gene splicing is common, and potentially a more sensitive measure of maturational state than gene expression profiling alone. In summary, this study highlights the value of genomic indices in refining and validating optimal cell populations appropriate for modelling ageing and neurodegeneration. PMID:22681703